Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions

International Nuclear Information System (INIS)

2007-01-01

This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

EL-3 dismantling of an experimental reactor

International Nuclear Information System (INIS)

1989-01-01

The EL3 experimental reactor has been definitively stopped in march 1979. Its decommissioning has been pronounced in the end of 1982. This article is consecrated at decontamination and dismantling works necessited by its passage at the dismantling level 2 [fr

4. Mexican School of Nuclear Physics. Papers

International Nuclear Information System (INIS)

Aguilera, E.F.; Hernandez, E.; Hirsch, J.

2005-01-01

The IV Mexican School of Nuclear Physics, organized by the Nuclear Physics Division of the Mexican Physics Society, takes place from June 27 to July 8, 2005 in the Nuclear Sciences and of Physics Institutes of the UNAM and in the National Institute of Nuclear Research (ININ). This school, as the previous ones, it was guided the students of the last semesters of the career of Physics, of the Post grade of the same specialty, and of other adjacent careers. To give the students a current vision of some of the topics more important of the nuclear physics and their relationship with other near areas of the physics it was the objective of this School. The School covered a wide range of theoretical and experimental courses, imparted in its majority by Mexican expert professor-investigators in the matter to who we thank them the one effort and the quality of their presentations, reflected in the content of this document. The answer of the students to the convocation was excellent, 31 students presented application for admission coming from the following institutions: Meritorious Autonomous University de Puebla, National Institute of Nuclear Research, Technological Institute of Orizaba, National Polytechnic Institute, The University of Texas at Brownsville, Autonomous University of the State de Mexico, Autonomous University of the State of Morelos, Autonomous University of Baja California, Autonomous University of San Luis Potosi, University of Guadalajara, University of Guanajuato, National Autonomous University of Mexico, University of Texas, at El Paso and University Veracruzana. They were admitted to the 22 students with the higher averages qualifications of the list of applicants. The organizers of this school thank the financial support granted by the following sponsor institutions: Nuclear Sciences Institute, UNAM, Physics Institute of UNAM, Coordination of the Scientific Research UNAM, National Institute of Nuclear Research, Nuclear Physics Division of the Mexican

Proyecto Estación Experimental Finca El Paraíso

OpenAIRE

Polliotto, Gabriela; Galíndez, Fernando; Lanusse, Mateo

2012-01-01

p. 27-31 El presente Proyecto desarrolla el diseño de un edificio destinado a estación experimental en Finca El Paraíso, ubicada en el departamento de Rivadavia Banda Norte, propiedad de la Universidad Católica de Salta. En el marco de la formulación de un plan de manejo sostenido para dicha finca, el edificio mencionado estará destinado a desarrollar las actividades necesarias para la gestión sostenible de la Finca, como así también para la realización de investigación, formación y extens...

Experimental techniques in nuclear and particle physics

International Nuclear Information System (INIS)

Tavernier, Stefaan

2010-01-01

The book is based on a course in nuclear and particle physics that the author has taught over many years to physics students, students in nuclear engineering and students in biomedical engineering. It provides the basic understanding that any student or researcher using such instruments and techniques should have about the subject. After an introduction to the structure of matter at the subatomic scale, it covers the experimental aspects of nuclear and particle physics. Ideally complementing a theoretically-oriented textbook on nuclear physics and/or particle physics, it introduces the reader to the different techniques used in nuclear and particle physics to accelerate particles and to measurement techniques (detectors) in nuclear and particle physics. The main subjects treated are: interactions of subatomic particles in matter; particle accelerators; basics of different types of detectors; and nuclear electronics. The book will be of interest to undergraduates, graduates and researchers in both particle and nuclear physics. For the physicists it is a good introduction to all experimental aspects of nuclear and particle physics. Nuclear engineers will appreciate the nuclear measurement techniques, while biomedical engineers can learn about measuring ionising radiation, the use of accelerators for radiotherapy. What's more, worked examples, end-of-chapter exercises, and appendices with key constants, properties and relationships supplement the textual material. (orig.)

El desarrollo nuclear de Argentina y el régimen de no proliferación

OpenAIRE

Colombo, Sandra; Guglielminotti, Cristian; Vera, María Nevia

2017-01-01

Resumen: El desarrollo y la transferencia de tecnología nuclear han sido puestos bajo estrictos controles debido a su posible derivación hacia el uso bélico, lo que ha llevado a crear un régimen internacional de no proliferación. Una de las últimas propuestas ha sido la fundación de bancos multilaterales de uranio levemente enriquecido (ule). Este artículo plantea que el objetivo de no proliferación puede contribuir a acentuar la asimetría en la distribución del poder económico-político mundi...

Experimental nuclear physics research in Hungary

International Nuclear Information System (INIS)

Koltay, Ede.

1984-01-01

The status and recent results of experimental nuclear physics in Hungary is reviewed. The basic nuclear sciences, instrumental background and international cooperation are discussed. Personal problems and the effects of the international scientific deconjuncture are described. The applied nuclear and interdisciplinary researches play an important role in Hungarian nuclear physics. Some problems of cooperation of Hungarian nuclear and other research institutes applying or producing nuclear analytical technology are reviewed. The new instrument, the Debrecen cyclotron under construction gives new possibilities to basic and applied researches. A new field of Hungarian nuclear physics is the fusion and plasma research using tokamak equipment, the main topics of which are plasma diagnostics and fusion control systems. Some practical applications of Hungarian nuclear physical results, e.g. establishment of new analytical techniques like PIXE, RBS, PIGE, ESCA, etc. are summarized. (D.Gy.)

VI European Summer School on Experimental Nuclear Astrophysics

Science.gov (United States)

The European Summer School on Experimental Nuclear Astrophysics has reached the sixth edition, marking the tenth year's anniversary. The spirit of the school is to provide a very important occasion for a deep education of young researchers about the main topics of experimental nuclear astrophysics. Moreover, it should be regarded as a forum for the discussion of the last-decade research activity. Lectures are focused on various aspects of primordial and stellar nucleosynthesis, including novel experimental approaches and detectors, indirect methods and radioactive ion beams. Moreover, in order to give a wide educational offer, some lectures cover complementary subjects of nuclear astrophysics such as gamma ray astronomy, neutron-induced reactions, short-lived radionuclides, weak interaction and cutting-edge facilities used to investigate nuclear reactions of interest for astrophysics. Large room is also given to young researcher oral contributions. Traditionally, particular attention is devoted to the participation of students from less-favoured countries, especially from the southern coast of the Mediterranean Sea. The school is organised by the Catania Nuclear Astrophysics research group with the collaboration of Dipartimento di Fisica e Astromomia - Università di Catania and Laboratori Nazionali del Sud - Istituto Nazionale di Fisica Nucleare.

Experimental studies of nuclear astrophysics

International Nuclear Information System (INIS)

He Jianjun; Zhou Xiaohong; Zhang Yuhu

2013-01-01

Nuclear astrophysics is an interdisciplinary subject combining micro-scale nuclear physics and macro-scale astrophysics. Its main aims are to understand the origin and evolution of the elements in the universe, the time scale of stellar evolution, the stellar environment and sites, the energy generation of stars from thermonuclear processes and its impact on stellar evolution and the mechanisms driving astrophysical phenomena, and the structure and property of compact stars. This paper presents the significance and current research status of nuclear astrophysics; we introduce some fundamental concepts, the nuclear physics input parameters required by certain astrophysics models, and some widely-used experimental approaches in nuclear astrophysics research. The potential and feasibility of research in this field using China’s current and planned large-scale scientific facilities are analyzed briefly. Finally, the prospects of the establishing a deep underground science and engineering laboratory in China are envisaged. (authors)

APLICACIONES CLÍNICAS DE LAS TÉCNICAS NUCLEARES EN EL ESTUDIO DEL SINCRONISMO VENTRICULAR / Clinical applications of nuclear techniques in the study of ventricular synchronism

Directory of Open Access Journals (Sweden)

Amalia Peix González

2012-07-01

Full Text Available ResumenTécnicas incruentas como la ecocardiografía, la resonancia magnética nuclear y los estudios de Medicina Nuclear (ventriculografía radioisotópica y gammagrafía de perfusión miocárdica con tomografía de emisión de fotón único, proporcionan información indirecta sobre el sincronismo ventricular cuando se utilizan parámetros de contractilidad mecánica. El análisis de fase de Fourier es un instrumento útil para el empleo de técnicas nucleares con este propósito y se ha aplicado, tanto en la ventriculografía radioisotópica como en la gammagrafía de perfusión. En este trabajo se presenta una revisión en el tiempo de los fundamentos y aplicaciones clínicas de las técnicas nucleares en el estudio del sincronismo ventricular. En la actualidad es la gammagrafía SPECT-gatillada, dentro de las técnicas nucleares, la más utilizada, por la posibilidad que ofrece de evaluar perfusión, función y sincronismo intraventricular en el mismo examen. / AbstractNoninvasive techniques such as echocardiography, nuclear magnetic resonance imaging and nuclear medicine studies (radionuclide ventriculography and myocardial perfusion scintigraphy with single photon emission tomography, provide indirect information about ventricular synchronism when parameters of mechanical contractility are used. The Fourier phase analysis is a useful tool for the use of nuclear techniques for this purpose, and has been applied in both radionuclide ventriculography and perfusion scintigraphy. A review in time of the basics and clinical applications of nuclear techniques in the study of ventricular synchronism is presented in this article. Nowadays, the gated-SPECT scintigraphy is the most common among nuclear techniques because it allows assessing perfusion, function, and intraventricular synchronism in the same test.

Perspectives of experimental nuclear physics research at RBI Croatia

International Nuclear Information System (INIS)

Soic, N.

2009-01-01

Experimental nuclear physics has been one of the top research activities at the Rudjer Boskovic Institute, the largest and leading Croatian research center in science and applications. The RBI nuclear physics group has strong link with the researchers at the University of Zagreb. RBI scientists perform experiments at the RBI Tandem accelerator facility and at the top European experimental facilities in collaboration with the prominent research groups in the field. Current status of the RBI experimental nuclear physics research and our recent activities aimed to strengthen our position at the RBI and to increase our international reputation and impact in collaborative projects will be presented. Part of these activities is focused on local accelerator facilities, at present mainly used for application research, and their increased usage for nuclear physics research and for development and testing of novel research equipment for large international facilities. Upgrade of the local research equipment is on the way through FP7 REGPOT project 'CLUNA: Clustering phenomena in nuclear physics: strengthening of the Zagreb-Catania-Birmingham partnership'. Recently, steps to exploit potential of the facility for nuclear astrophysics research have been initiated. Possible future actions for further strengthening of the RBI experimental nuclear physics research will be discussed.(author)

Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells.

Science.gov (United States)

Yea, S S; Yang, K H; Kaminski, N E

2000-02-01

We previously reported that immunosuppressive cannabinoids inhibited interleukin (IL)-2 steady-state mRNA expression and secretion by phorbol-12-myristate-13-acetate plus ionomycin-activated mouse splenocytes and EL4 murine T-cells. Here we show that inhibition of IL-2 production by cannabinol, a modest central nervous system-active cannabinoid, is mediated through the inhibition of IL-2 gene transcription. Moreover, electrophoretic mobility shift assays demonstrated that cannabinol markedly inhibited the DNA binding activity of nuclear factor of activated T-cells (NF-AT) and activator protein-1 (AP-1) in a time- and concentration-dependent manner in activated EL4 cells. The inhibitory effects produced by cannabinol on AP-1 DNA binding were quite transient, showing partial recovery by 240 min after cell activation and no effect on the activity of a reporter gene under the control of AP-1. Conversely, cannabinol-mediated inhibition of NF-AT was robust and sustained as demonstrated by an NF-AT-regulated reporter gene. Collectively, these results suggest that decreased IL-2 production by cannabinol in EL4 cells is due to the inhibition of transcriptional activation of the IL-2 gene and is mediated, at least in part, through a transient inhibition of AP-1 and a sustained inhibition of NF-AT.

L'energia nuclear: pot resoldre el problema de l'escalfament global?

OpenAIRE

Puig, Josep

2006-01-01

Sovint es diu que l'energia nuclear pot ser la solució pel problema de l'escalfament global: l'article presenta dades i raonaments per concloure que, si tota l'electricitat mundial fos d'origen nuclear, l'escalfament global es reduiria tan sols en un 12%. També s'analitzen els subproductes militars de la indústria de l'energia nuclear "civil" i la problemàtica dels residus radioactius de l'energia nuclear de fissió. També s'analitza l'alt grau de dificultats que presenta l'energia nuclear de ...

Program X4TOC4 (Version 86-1). Translation of experimental data from the EXFOR format to a computation format

International Nuclear Information System (INIS)

Cullen, D.E.

1986-09-01

Experimental nuclear reaction data are world-wide compiled in EXFOR format. The computer program X4TOC4 described in the present document translates data from the rather flexible EXFOR format to the more rigid ''computation format'' which is suitable for input to further computer processing of the data including graphical plotting. The program is available costfree from the IAEA Nuclear Data Section, upon request. (author)

Efectos de un programa experimental en el desarrollo de la competencia comunicativa de estudiantes universitarios

OpenAIRE

Mesias Ratto, Rosa Victoria

2015-01-01

Analiza los efectos de un programa experimental en el desarrollo de la competencia comunicativa de los estudiantes del primer ciclo de la Facultad de Ciencias Contables de la Universidad Nacional del Callao en el semestre 2013-B. Se empleó el diseño experimental con preprueba – postprueba y grupo de control. Los instrumentos utilizados fueron el Test de Matrices Progresivas J. C. Raven (como instrumento filtro); el Test de Comprensión Lectora de Violeta Tapia y Maritza Silva (forma abreviada)...

Nuclear test-experimental science annual report, Fiscal year 1990

International Nuclear Information System (INIS)

Struble, G.L.; Middleton, C.; Anderson, S.E.; Cherniak, J.; Donohue, M.L.; Francke, A.; Hedman, I.; Kirvel, R.D.

1991-01-01

Fiscal year 1990 was another year of outstanding accomplishments for the Nuclear Test-Experimental Science (NTES) Program at Lawrence Livermore National Laboratory (LLNL). We continued to make progress to enhance the experimental science in the Weapons Program and to improve the operational efficiency and productivity of the Nuclear Test Program

Analysis of experimental data on relativistic nuclear collisions in the Lobachevsky space

International Nuclear Information System (INIS)

Baldin, A.A.; Baldina, Eh.G.; Kladnitskaya, E.N.; Rogachevskij, O.V.

2004-01-01

Relativistic nuclear collisions are considered in terms of relative 4-velocity and rapidity space (the Lobachevsky space). The connection between geometric relations in the Lobachevsky space and measurable (experimentally determined) kinematic characteristics (transverse momentum, longitudinal rapidity, square relative 4-velocity b ik , etc.) is discussed. The experimental data obtained using the propane bubble chamber are analyzed on the basis of triangulation in the Lobachevsky space. General properties of relativistic invariants distributions characterizing the geometric position of particles in the Lobachevsky space are discussed. The transition energy region is considered on the basis of relativistic approach to experimental data on multiparticle processes. Possible applications of the obtained results for planning of experimental research and analysis of data on multiple particle production are discussed

Experimental Seminar on Nuclear Energy for Teachers

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-02-01

`Experimental Seminar on Nuclear Energy for Teachers` was conducted and sponsored by the Science and Technology Agency. And in order to understand nuclear energy properly through lectures and experiments with good results inclass, the seminar carried out for teachers of high schools and junior high schools by the Nuclear Technology and Education Center (NuTEC), Japan Atomic Energy Research Institute in 1990 FY to 1997 FY. In this report, details of the seminars in the above period are described and No.1 to 17 of Communication Letters of Experimental Seminar on Nuclear Energy` started at 1992 FY are described also. These letters were prepared for attendant follow-up program. And programs of recent seminars, future`s seminars, impressions and comments from attendants, reports from actual classes and others are described in these letters and they are very useful for educational classes on nuclear energy by other teachers. Therefore contents of the letters are listed and easy to refer. A part of this educational task was transferred to the Radiation Application Development Association in 1997 FY and other parts were transferred in 1998 FY. (author)

Estudio numerico y experimental del proceso de soldeo MIG sobre la aleacion 6063--T5 utilizando el metodo de Taguchi

Science.gov (United States)

Meseguer Valdenebro, Jose Luis

improvement on mechanical properties in aluminum metal joint. Los procesos de soldadura por arco electrico representan unas de las tecnicas mas utilizadas en los procesos de fabricacion de componentes mecanicos en la industria moderna. Los procesos de soldeo por arco se han adaptado a las necesidades actuales, haciendose un modo de fabricacion flexible y versatil. Los resultados obtenidos numericamente en el proceso de soldadura son validados experimentalmente. Los principales metodos numericos mas empleados en la actualidad son tres, metodo por diferencias finitas, metodos por elementos finitos y metodo por volumenes finitos. El metodo numerico mas empleado para el modelado de uniones soldadas, es el metodo por elementos finitos, debido a que presenta una buena adaptacion a las condiciones geometricas y de contorno ademas de que existe una diversidad de programas comerciales que utilizan el metodo por elementos finitos como base de calculo. Este trabajo de investigacion presenta un estudio experimental de una union soldada mediante el proceso MIG de la aleacion de aluminio 6063-T5. El metodo numerico se valida experimentalmente aplicando el metodo de los elementos finitos con el programa de calculo ANSYS. Los resultados experimentales obtenidos son: las curvas de enfriamiento, el tiempo critico de enfriamiento t4/3, geometria del cordon, microdurezas obtenidas en la union soldada, zona afectada termicamente y metal base, dilucion del proceso, areas criticas intersecadas entre las curvas de enfriamiento y la curva TTP. Los resultados numericos son: las curvas del ciclo termico, que representan tanto el calentamiento hasta alcanzar la temperatura maxima y un posterior enfriamiento. Se calculan el tiempo critico de enfriamiento t4/3, el rendimiento termico y se representa la geometria del cordon obtenida experimentalmente. La zona afectada termicamente se obtiene diferenciando las zonas que se encuentran a diferentes temperaturas, las areas criticas intersecadas entre las

Simulated nuclear optical signatures using explosive light sources (ELS)

International Nuclear Information System (INIS)

Glaser, R.F.

1979-05-01

Four Explosive Light Source (aluminium powder and oxygen) tests were conducted on the test range at Sandia Laboratories in Albuquerque (SLA) from 28 February through 7 March 1978. Although several types of measuring devices were used, the report documents only the optical time histories measured by the bhangmeters and the NBDS, and explains the conclusions reached. In general, the four shots made it possible to gather clear-air optical transmission data, determine the suitability of ELS to simulate the optical effects of a nuclear burst, and provide experience for the larger scale ELS tests to be conducted at Fort Ord, CA in April

Simulated nuclear optical signatures using explosive light sources (ELS)

Energy Technology Data Exchange (ETDEWEB)

Glaser, R.F.

1979-05-01

Four Explosive Light Source (aluminium powder and oxygen) tests were conducted on the test range at Sandia Laboratories in Albuquerque (SLA) from 28 February through 7 March 1978. Although several types of measuring devices were used, the report documents only the optical time histories measured by the bhangmeters and the NBDS, and explains the conclusions reached. In general, the four shots made it possible to gather clear-air optical transmission data, determine the suitability of ELS to simulate the optical effects of a nuclear burst, and provide experience for the larger scale ELS tests to be conducted at Fort Ord, CA in April.

Improvement of macrophage dysfunction by administration of anti-transforming growth factor-beta antibody in EL4-bearing hosts.

Science.gov (United States)

Maeda, H; Tsuru, S; Shiraishi, A

1994-11-01

An experimental therapy for improvement of macrophage dysfunction caused by transforming growth factor-beta (TGF-beta) was tried in EL4 tumor-bearing mice. TGF-beta was detected in cell-free ascitic fluid from EL4-bearers, but not in that from normal mice, by western blot analysis. The ascites also showed growth-suppressive activity against Mv1Lu cells, and the suppressive activity was potentiated by transient acidification. To investigate whether the functions of peritoneal macrophages were suppressed in EL4-bearers, the abilities to produce nitric oxide and tumor necrosis factor-alpha (TNF-alpha) upon lipopolysaccharide (LPS) stimulation were measured. Both abilities of macrophages in EL4-bearing mice were suppressed remarkably on day 9, and decreased further by day 14, compared with non-tumor-bearing controls. TGF-beta activity was abrogated by administration of anti-TGF-beta antibody to EL4-bearing mice. While a large amount of TGF-beta was detected in ascitic fluid from control EL4-bearers, little TGF-beta was detectable in ascites from EL4-bearers given anti-TGF-beta antibody. Furthermore, while control macrophages exhibited little or no production of nitric oxide and TNF-alpha on LPS stimulation in vitro, macrophages from EL4-bearers administered with anti-TGF-beta antibody showed the same ability as normal macrophages. These results clearly indicate that TGF-beta contributes to macrophage dysfunction and that the administration of specific antibody for TGF-beta reverses macrophage dysfunction in EL4-bearing hosts.

Experimental qualification of nuclear components

Energy Technology Data Exchange (ETDEWEB)

Alliot, P; Fronte, T; Genty, F [FRAMATOME - Cedex 16, Paris la Defense (France)

1988-07-01

In the process of showing the adequacy of the seismic design of French PWR reactor, Fermat has repeatedly used dynamic testing on actual nuclear reactor components both on site and in manufacturing shops. The objective and results of a few representative examples of this on-site experimental verification are presented in this paper: the experimental dynamic analysis of a manipulator crane; the investigation of the seismic behaviour of fuel storage racks equipped with aseismic bearing devices. Difficulties to select satisfactory testing methods are also discussed for the particular case of the electrical cabinets. (author)

Experimental qualification of nuclear components

International Nuclear Information System (INIS)

Alliot, P.; Fronte, T.; Genty, F.

1988-01-01

In the process of showing the adequacy of the seismic design of French PWR reactor, Fermat has repeatedly used dynamic testing on actual nuclear reactor components both on site and in manufacturing shops. The objective and results of a few representative examples of this on-site experimental verification are presented in this paper: the experimental dynamic analysis of a manipulator crane; the investigation of the seismic behaviour of fuel storage racks equipped with aseismic bearing devices. Difficulties to select satisfactory testing methods are also discussed for the particular case of the electrical cabinets. (author)

Experimental nuclear physics research challenges at low energies

Energy Technology Data Exchange (ETDEWEB)

Chavez, E.; Morales G, L. [UNAM, Instituto de Fisica, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Murillo O, G. [ININ, Carretera Mexico-Toluca s/n, Ocoyoacac 52750, Estado de Mexico (Mexico)

2010-02-15

Experimental research with low energy beams of ions (a few MeV) in nuclear physics has gone through a phase transition along its evolution in fifty years because of the increasing complexity (and cost) of the equipment required to conduct meaningful investigations. Many of the small cyclotrons and Van de Graaff (single ended and tandem) accelerators have been used for the last three decades mostly in applications related to the characterization and modification of materials. Specific experimental investigations in nuclear physics with low energy accelerators are proposed in this work. Specifically we discuss the topic of nuclear radii measurements of radioactive species produced via (d,n) reactions. Some emphasis is given to the instrumentation required. (Author)

Experimental grounds for nuclear shape isomerism

International Nuclear Information System (INIS)

Makarenko, V.E.

1995-11-01

Experimental data on fission isomeric states of actinide nuclei - half lives, energies, quantum numbers, decay branches and spectroscopic properties - are discussed. Quite a few results find their explanation in the framework of nuclear shape isomerism hypothesis being the in-thing for about thirty years. Others seem to be the hints to the quasiparticle nature of fission isomers. The problem could be solved by direct measurement of nuclear spin for isomeric states. (author). 44 refs, 1 tab

Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB.

Science.gov (United States)

Singh, Narendra P; Singh, Udai P; Hegde, Venkatesh L; Guan, Hongbing; Hofseth, Lorne; Nagarkatti, Mitzi; Nagarkatti, Prakash S

2011-08-01

Understanding the molecular mechanisms through which natural products and dietary supplements exhibit anticancer properties is crucial and can lead to drug discovery and chemoprevention. The current study sheds new light on the mode of action of resveratrol (RES), a plant-derived polyphenolic compound, against EL-4 lymphoma growth. Immuno-compromised NOD/SCID mice injected with EL-4 tumor cells and treated with RES (100 mg/kg body weight) showed delayed development and progression of tumor growth and increased mean survival time. RES caused apoptosis in EL4 cells through activation of aryl hydrocarbon receptor (AhR) and upregulation of Fas and FasL expression in vitro. Blocking of RES-induced apoptosis in EL4 cells by FasL mAb, cleavage of caspases and PARP, and release of cytochorme c, demonstrated the participation of both extrinsic and intrinsic pathways of apoptosis. RES also induced upregulation of silent mating type information regulation 2 homolog, 1 (SIRT1) and downregulation of nuclear factor kappa B (NF-κB) in EL4 cells. siRNA-mediated downregulation of SIRT1 in EL4 cells increased the activation of NF-κB but decreased RES-mediated apoptosis, indicating the critical role of SIRT1 in apoptosis via blocking activation of NF-κB. These data suggest that RES-induced SIRT1 upregulation promotes tumor cell apoptosis through negative regulation of NF-κB, leading to suppression of tumor growth. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Nuclear Test-Experimental Science: Annual report, fiscal year 1988

Energy Technology Data Exchange (ETDEWEB)

Struble, G.L.; Donohue, M.L.; Bucciarelli, G.; Hymer, J.D.; Kirvel, R.D.; Middleton, C.; Prono, J.; Reid, S.; Strack, B. (eds.)

1988-01-01

Fiscal year 1988 has been a significant, rewarding, and exciting period for Lawrence Livermore National Laboratory's nuclear testing program. It was significant in that the Laboratory's new director chose to focus strongly on the program's activities and to commit to a revitalized emphasis on testing and the experimental science that underlies it. It was rewarding in that revolutionary new measurement techniques were fielded on recent important and highly complicated underground nuclear tests with truly incredible results. And it was exciting in that the sophisticated and fundamental problems of weapons science that are now being addressed experimentally are yielding new challenges and understanding in ways that stimulate and reward the brightest and best of scientists. During FY88 the program was reorganized to emphasize our commitment to experimental science. The name of the program was changed to reflect this commitment, becoming the Nuclear Test-Experimental Science (NTES) Program.

Experimental techniques in nuclear and particle physics

CERN Document Server

Tavernier, Stefaan

2009-01-01

The book is based on a course in nuclear and particle physics that the author has taught over many years to physics students, students in nuclear engineering and students in biomedical engineering. It provides the basic understanding that any student or researcher using such instruments and techniques should have about the subject. After an introduction to the structure of matter at the subatomic scale, it covers the experimental aspects of nuclear and particle physics. Ideally complementing a theoretically-oriented textbook on nuclear physics and/or particle physics, it introduces the reader to the different techniques used in nuclear and particle physics to accelerate particles and to measurement techniques (detectors) in nuclear and particle physics. The main subjects treated are: interactions of subatomic particles in matter; particle accelerators; basics of different types of detectors; and nuclear electronics. The book will be of interest to undergraduates, graduates and researchers in both particle and...

Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

. El nivel de los Factores que afectan el calendario de vacunación en niños menores de 4 años del centro de salud Año Nuevo-2016

OpenAIRE

La Rosa Asencios, Maura America

2017-01-01

El presente trabajo de investigación tuvo como objetivo determinar el nivel de los factores que afectan el calendario de vacunación de los niños menores de 4 años en el centro de salud Año Nuevo en el año 2016 el método empleado es netamente descriptivo simple diseño no experimental es cuantitativo la muestra estuvo constituida por 54 madres que acuden al servicio de vacunación el instrumento utilizado es un formulario tipo cuestionario que consta de 30 preguntas las 10 prim...

Sistema experimental para el monitoreo de instalaciones de potencia haciendo uso de la Web; Experimental System for Power Installations Samples by Using the Web

Directory of Open Access Journals (Sweden)

Yoel R Rosales Hernández

2011-02-01

Full Text Available El artículo que se presenta describe una alternativa económica de sistema de adquisición de datos parael monitoreo de una instalación de potencia eléctrica trifásica. El sistema experimental está basado en unmicrocontrolador de Intel StrongARM SA-1110 de 32 bits con CPU RISC, una memoria flash de 16 Mbyte,una memoria SDRAM de 32 Mbyte y un controlador LAN Ethernet de 10/100 Mbps entre otros elementos.El mismo tiene instalado un sistema operativo Linux (kernel versión 2.4 y un servidor web thttpd. Através de un programa CGI se logra el muestreo, procesamiento y transmisión de la información recibidadesde un sistema trifásico de potencia y a partir de un protocolo HTTP se envía toda esta información aun grupo de clientes conectados a una red convencional de computadoras.  This work focuses on an economic alternative for developing a data acquisition system which monitors athree-phase power intalation. This experimental system is made up of an Intel StrongARM SA-1110 32-bitRISC microcontroller, a 16-Mbyte flash memory chip, a 32-MByte SDRAM chip, a 10/100 Mbps EthernetLAN controller with 10BASE-T, as well as other  hardware elements. The system has an embedded Linuxoperating system (kernel version 2.4, and a thttpd embedded web server. A CGI program was designed inorder to enable the sampling, processing and transmition of information received from the three-phasepower installation. To achieve this, a HTTP protocol was used in order to send all this information to agroup of clients connected to a conventional PC network.

Existing experimental criticality data applicable to nuclear-fuel-transportation systems

International Nuclear Information System (INIS)

Bierman, S.R.

1983-02-01

Analytical techniques are generally relied upon in making criticality evaluations involving nuclear material outside reactors. For these evaluations to be accepted the calculations must be validated by comparison with experimental data for a known set of conditions having physical and neutronic characteristics similar to those conditions being evaluated analytically. The purpose of this report is to identify those existing experimental data that are suitable for use in verifying criticality calculations on nuclear fuel transportation systems. In addition, near term needs for additional data in this area are identified. Of the considerable amount of criticality data currently existing, that are applicable to non-reactor systems, those particularly suitable for use in support of nuclear material transportation systems have been identified and catalogued into the following groups: (1) critical assemblies of fuel rods in water; (2) critical assemblies of fuel rods in water containing soluble neutron absorbers; (3) critical assemblies containing solid neutron absorber; (4) critical assemblies of fuel rods in water with heavy metal reflectors; and (5) critical assemblies of fuel rods in water with irregular features. A listing of the current near term needs for additional data in each of the groups has been developed for future use in planning criticality research in support of nuclear fuel transportation systems. The criticality experiments needed to provide these data are briefly described and identified according to priority and relative cost of performing the experiments

STACY and TRACY: nuclear criticality experimental facilities under construction

International Nuclear Information System (INIS)

Kobayashi, I.; Takeshita, I.; Yanagisawa, H.; Tsujino, T.

1992-01-01

Japan Atomic Energy Research Institute is constructing a Nuclear Fuel Cycle Safety Engineering Research Facility, NUCEF, where the following research themes essential for evaluating safety problems relating to back-end technology in nuclear fuel cycle facilities will be studied: nuclear criticality safety research; research on advanced reprocessing processes and partitioning; and research on transuranic waste treatment and disposal. To perform nuclear criticality safety research related to the reprocessing of light water reactor spent fuels, two criticality experimental facilities, STACY and TRACY, are under construction. STACY (Static Criticality Facility) will be used for the study of criticality conditions of solution fuels, uranium, plutonium and their mixtures. TRACY (Transient Criticality Facility) will be used to investigate criticality accident phenomena with uranium solutions. The construction progress and experimental programmes are described in this Paper. (author)

B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.

Science.gov (United States)

Stremmel, C; Greenfield, E A; Howard, E; Freeman, G J; Kuchroo, V K

1999-03-15

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the "second signal" pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4-B7-1 cells are completely rejected in syngeneic mice. Unlike EL4-B7-1 cells, we find that EL4-B7-2 cells are not rejected but progressively grow in the mice. A B7-1- and B7-2-EL4 double transfectant was generated by introducing B7-2 cDNA into the EL4-B7-1 tumor line that regressed in vivo. The EL4-B7-1+B7-2 double transfectant was not rejected when implanted into syngeneic mice but progressively grew to produce tumors. The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked by anti-B7-1 antibodies, anti-B7-2 antibodies, or hCTLA4 immunoglobulin, showing that the B7-1 and B7-2 molecules expressed on the EL4 cells were functional. In vivo, treatment of mice implanted with double-transfected EL4 cells with anti-B7-2 monoclonal antibody resulted in tumor rejection. Furthermore, the EL4-B7-2 and EL4-B7-1+B7-2 cells, but not the wild-type EL4 cells, were rejected in interleukin 4 (IL-4) knockout mice. Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response.

Experimental energy-dependent nuclear spin distributions

International Nuclear Information System (INIS)

Egidy, T. von; Bucurescu, D.

2009-01-01

A new method is proposed to determine the energy-dependent spin distribution in experimental nuclear-level schemes. This method compares various experimental and calculated moments in the energy-spin plane to obtain the spin-cutoff parameter σ as a function of mass A and excitation energy using a total of 7202 levels with spin assignment in 227 nuclei between F and Cf. A simple formula, σ 2 =0.391 A 0.675 (E-0.5Pa ' ) 0.312 , is proposed up to about 10 MeV that is in very good agreement with experimental σ values and is applied to improve the systematics of level-density parameters.

JENDL-4.0: A new library for nuclear science and engineering

International Nuclear Information System (INIS)

Shibata, Keiichi; Iwamoto, Osamu; Nakagawa, Tsuneo; Iwamoto, Nobuyuki; Ichihara, Akira; Kunieda, Satoshi; Chiba, Satoshi; Furutaka, Kazuyoshi; Katakura, Jun-ichi; Otuka, Naohiko; Ohsawa, Takaaki; Murata, Toru; Matsunobu, Hiroyuki; Zukeran, Atsushi; Kamada, So

2011-01-01

The fourth version of the Japanese Evaluated Nuclear Data Library has been produced in cooperation with the Japanese Nuclear Data Committee. In the new library, much emphasis is placed on the improvements of fission product and minor actinoid data. Two nuclear model codes were developed in order to evaluate the cross sections of fission products and minor actinoids. Coupled-channel optical model parameters, which can be applied to wide mass and energy regions, were obtained for nuclear model calculations. Thermal cross sections of actinoids were carefully examined by considering experimental data or by the systematics of neighboring nuclei. Most of the fission cross sections were derived from experimental data. A simultaneous evaluation was performed for the fission cross sections of important uranium and plutonium isotopes above 10 keV. New evaluations were performed for the thirty fission-product nuclides that had not been contained in the previous library JENDL-3.3. The data for light elements and structural materials were partly reevaluated. Moreover, covariances were estimated mainly for actinoids. The new library was released as JENDL-4.0, and the data can be retrieved from the Web site of the JAEA Nuclear Data Center. (author)

The Nuclear Safety Council in the National System of Nuclear and Radiological Emergencies. Functions, organization and new international trends; El Consejo de Seguridad Nuclear en el Sistema Nacional de Emergencias Nucleares y Radiológicas. Funciones, organización y nuevas tendencias internacionales

Energy Technology Data Exchange (ETDEWEB)

Mozas García, A.; Martín Calvarro, J.M.; García Cadierno, J.P.; Calvín Cuartero, M.

2015-07-01

This article describes the role of the Spanish Nuclear Safety Council (CSN) in the coordination of nuclear and radiológicas emergencies, and how they engage with the National Nuclear and Radiological Emergency System. To accomplish its functions, the CSN, has set up the Emergency Response Organization (ORE), which structure, functions and procedures are also described in this work. Finally, the new international trends that are being developed on emergency preparedness and response as a consequence of the lessons learned from recent disasters are reported. [Spanish] Este artículo revisa las funciones que el Consejo de Seguridad tiene en la coordinación de las emergencias nucleares y radiológicas, y cómo se engranan éstas en el Sistema Nacional de Emergencias. A partir de las funciones que tiene encomendadas se describe la organización del CSN en emergencias y la estructura de los apoyos con los que cuenta para cumplir con aquéllas. Por último, se revisan las tendencias que, a nivel internacional, se están desarrollando para incorporar a la preparación de la respuesta a emergencias las lecciones aprendidas de las últimas catástrofes ocurridas.

Benchmarking nuclear models of FLUKA and GEANT4 for carbon ion therapy

CERN Document Server

Bohlen, TT; Quesada, J M; Bohlen, T T; Cerutti, F; Gudowska, I; Ferrari, A; Mairani, A

2010-01-01

As carbon ions, at therapeutic energies, penetrate tissue, they undergo inelastic nuclear reactions and give rise to significant yields of secondary fragment fluences. Therefore, an accurate prediction of these fluences resulting from the primary carbon interactions is necessary in the patient's body in order to precisely simulate the spatial dose distribution and the resulting biological effect. In this paper, the performance of nuclear fragmentation models of the Monte Carlo transport codes, FLUKA and GEANT4, in tissue-like media and for an energy regime relevant for therapeutic carbon ions is investigated. The ability of these Monte Carlo codes to reproduce experimental data of charge-changing cross sections and integral and differential yields of secondary charged fragments is evaluated. For the fragment yields, the main focus is on the consideration of experimental approximations and uncertainties such as the energy measurement by time-of-flight. For GEANT4, the hadronic models G4BinaryLightIonReaction a...

Experimental nuclear physics. Progress report, August 1985-August 1986

International Nuclear Information System (INIS)

1986-01-01

The research activities of the experimental nuclear structure group at Vanderbilt University are reported here. Research continues in the areas of (1) in-beam γ-ray spectroscopy; (2) studies of nuclei far from stability at UNISOR and at the recoil mass spectrometer at the University of Rochester; (3) nucleon transfer reaction and fusion-fission studies; and (4) theoretical studies. In general, abstracts of papers published or submitted for publication in this period make up this report along with brief reports of work in process and complete copies of a few conference papers

Estudio experimental sobre el comportamiento térmico de un nuevo tipo de techo-estanque para el enfriamiento pasivo en clima húmedo

Directory of Open Access Journals (Sweden)

Eduardo Manuel González-Cruz

Full Text Available En este trabajo, una nueva tipología de techo-estanque metálico, basado en el enfriamiento evaporativo indirecto, que incluye masa térmica confinada, se evalúa experimentalmente. Cinco sistemas de enfriamiento pasivo se han estudiado con este dispositivo experimental. Se analizan sus temperaturas características con el propósito de determinar en cada caso, su potencial de enfriamiento, así como, la influencia de la masa térmica en su comportamiento térmico. Entre las técnicas de enfriamiento pasivo aplicadas se encuentran el enfriamiento evaporativo indirecto (EEI y el enfriamiento radiativo nocturno (ER. El sistema donde se combina masa térmica con enfriamiento evaporativo indirecto en el dispositivo experimental presenta una elevada eficiencia de enfriamiento; su valor aumenta a medida que las condiciones son más extremas. Un potencial de enfriamiento aun mayor se consigue al agregar al sistema anterior enfriamiento radiativo.

Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell lines.

Science.gov (United States)

Zhang, Zhihong; Knoepp, Stewart M; Ku, Hsun; Sansbury, Heather M; Xie, Yuhuan; Chahal, Manpreet S; Tomlinson, Stephen; Meier, Kathryn E

2011-08-01

The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA). In sensitive cells, PMA causes Erk MAPK activation and Erk-mediated growth arrest. In resistant cells, PMA induces a low level of Erk activation, without growth arrest. A relatively unexplored aspect of the phenotypes is that resistant cells are more adherent to culture substrate than are sensitive cells. In this study, the roles of the protein tyrosine kinases FAK and Pyk2 in EL4 phenotype were examined, with a particular emphasis on the role of these proteins in metastasis. FAK is expressed only in PMA-resistant (or intermediate phenotype) EL4 cells, correlating with enhanced cell-substrate adherence, while Pyk2 is more highly expressed in non-adherent PMA-sensitive cells. PMA treatment causes modulation of mRNA for FAK (up-regulation) and Pyk2 (down-regulation) in PMA-sensitive but not PMA-resistant EL4 cells. The increase in Pyk2 mRNA is correlated with an increase in Pyk2 protein expression. The roles of FAK in cell phenotype were further explored using transfection and knockdown experiments. The results showed that FAK does not play a major role in modulating PMA-induced Erk activation in EL4 cells. However, the knockdown studies demonstrated that FAK expression is required for proliferation and migration of PMA-resistant cells. In an experimental metastasis model using syngeneic mice, only FAK-expressing (PMA-resistant) EL4 cells form liver tumors. Taken together, these studies suggest that FAK expression promotes metastasis of EL4 lymphoma cells.

B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism

Science.gov (United States)

Stremmel, C.; Greenfield, E.A.; Howard, E.; Freeman, G.J.; Kuchroo, V.K.

1999-01-01

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the “second signal” pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4–B7-1 cells are completely rejected in syngeneic mice. Unlike EL4–B7-1 cells, we find that EL4–B7-2 cells are not rejected but progressively grow in the mice. A B7-1– and B7-2–EL4 double transfectant was generated by introducing B7-2 cDNA into the EL4–B7-1 tumor line that regressed in vivo. The EL4–B7-1+B7-2 double transfectant was not rejected when implanted into syngeneic mice but progressively grew to produce tumors. The double transfectant EL4 cells could costimulate T cell proliferation that could be blocked by anti–B7-1 antibodies, anti–B7-2 antibodies, or hCTLA4 immunoglobulin, showing that the B7-1 and B7-2 molecules expressed on the EL4 cells were functional. In vivo, treatment of mice implanted with double-transfected EL4 cells with anti–B7-2 monoclonal antibody resulted in tumor rejection. Furthermore, the EL4–B7-2 and EL4–B7-1+B7-2 cells, but not the wild-type EL4 cells, were rejected in interleukin 4 (IL-4) knockout mice. Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response. PMID:10075975

Actions needed for RA reactor exploitation - I-IV, Part II, Design project VI-SA 1, Experimental loop for testing the EL-4 reactor fuel elements in the central vertical experimental channel of the RA reactor in Vinca

International Nuclear Information System (INIS)

Novakovic, M.

1961-12-01

The objective of installing the VISA-1 loop was testing the fuel elements of the EL-4 reactor. The fuel elements planned for testing are natural UO 2 with beryllium cladding, cooled by CO 2 under nominal pressure of 60 at and temperature 600 deg C. central vertical experimental channel of the RA reactor was chosen for installing a test loop cooled by CO 2 . This report contains the detailed design project of the testing loop with the control system and safety analysis of the planned experiment

Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma.

Science.gov (United States)

Říhová, Blanka; Etrych, Tomáš; Šírová, Milada; Tomala, Jakub; Ulbrich, Karel; Kovář, Marek

2011-12-01

We have investigated the effects of low-frequency pulsed electromagnetic field (LF-EMF) produced by BEMER device on experimental mouse T-cell lymphoma EL4 growing on conventional and/or athymic (nude) mice. Exposure to EMF-BEMER slowed down the growth of tumor mass and prolonged the survival of experimental animals. The effect was more pronounced in immuno-compromised nude mice compared to conventional ones. Acceleration of tumor growth was never observed. No measurable levels of Hsp 70 or increased levels of specific anti-EL4 antibodies were detected in the serum taken from experimental mice before and at different intervals during the experiment, i.e. before solid tumor appeared, at the time of its aggressive growth, and at the terminal stage of the disease. A significant synergizing antitumor effect was seen when EL4 tumor-bearing mice were simultaneously exposed to EMF-BEMER and treated with suboptimal dose of synthetic HPMA copolymer-based doxorubicin, DOX(HYD)-HPMA. Such a combination may be especially useful for heavily treated patients suffering from advanced tumor and requiring additional aggressive chemotherapy which, however, at that time could represent almost life-threatening way of medication.

Nuclear analysis of the experimental VHTR fuel lattice

International Nuclear Information System (INIS)

Doi, Takeshi; Shindo, Ryuiti; Hirano, Mitsumasa; Takano, Makoto

1984-11-01

Nuclear properties of a fuel lattice in the experimental VHTR core were analyzed with DELIGHT-6 and SRAC codes. Analytical results by both codes were compared by using various calculational model. The nuclear parameters were analyzed, such as a multiplication factor of a fuel lattice and it's variation with burnup, a temperature effect on reactivity, an effect of double-heterogeniety in a resonance absorption calculation, a resonance integral of 238 U and a reactivity worth of burnable poison. From these analyses, following results were obtained. Firstly, on calculational models, 1) Effect of double-heterogeniety in the resonance absorption calculation for Mark-III fuel element, causing a decrease of about 5.5 barns in the resonance integral and an increase of about 2.6 %ΔK in the infinite multiplication factor, 2) The heterogeneous calculation with the collision probability method resulted in about 0.6 %ΔK higher the multiplication factor of fuel lattice than that with the point model, 3) The reactivity worth of burnable poison rod by a multi-region model is about 20 % less than that by a 2-region model at an initial state of burnup and it's variation with burnup are fairly different, Secondly, on comparison between the results by DELIGHT-6 and SRAC, 4) The nuclear parameters obtained with both codes agreed well, Lastly, on the improvement in DELIGHT-6, 5) Consideration of the neutron spectrum shielding effect in the resonance effective cross section calculation caused a decrease of about 2.4 %ΔK in the multiplication factor of fuel lattice, 6) The lattice multiplication factor increased about 0.5 %ΔK by introducing lambda-parameters for the non-resonant nuclie. (J.P.N.)

Review of nuclear data improvement needs for nuclear radiation measurement techniques used at the CEA experimental reactor facilities

Directory of Open Access Journals (Sweden)

Destouches Christophe

2016-01-01

Full Text Available The constant improvement of the neutron and gamma calculation codes used in experimental nuclear reactors goes hand in hand with that of the associated nuclear data libraries. The validation of these calculation schemes always requires the confrontation with integral experiments performed in experimental reactors to be completed. Nuclear data of interest, straight as cross sections, or elaborated ones such as reactivity, are always derived from a reaction rate measurement which is the only measurable parameter in a nuclear sensor. So, in order to derive physical parameters from the electric signal of the sensor, one needs specific nuclear data libraries. This paper presents successively the main features of the measurement techniques used in the CEA experimental reactor facilities for the on-line and offline neutron/gamma flux characterizations: reactor dosimetry, neutron flux measurements with miniature fission chambers and Self Power Neutron Detector (SPND and gamma flux measurements with chamber ionization and TLD. For each technique, the nuclear data necessary for their interpretation will be presented, the main identified needs for improvement identified and an analysis of their impact on the quality of the measurement. Finally, a synthesis of the study will be done.

Experimental (Network) and Evaluated Nuclear Reaction Data at NDS

International Nuclear Information System (INIS)

Otsuka, N.; Semkova, V.; Simakov, S.P.; Zerkin, V.

2011-01-01

Dr Simakov of Nuclear Data Services Unit in the Nuclear Data Section (NDS) gave a brief overview of the data compilation and evaluation activities in the nuclear data community: experimental nuclear reaction data (EXFOR, http://www-nds.iaea.org/exfor/) and evaluated nuclear reaction data (ENDF, http://www-nds.iaea.org/endf). The International Network of Nuclear Reaction Data Centres (NRDC) coordinated by NDS includes 14 Centres in 8 Countries (China, Hungary, India, Japan, Korea, Russian, Ukraine, USA) and 2 International Organizations (NEA, IAEA). It had the first meeting of four core centres (Brookhaven, Saclay, Obninsk, Vienna) in 1966 and the EXFOR was adopted as an official data exchange format. In 2000, IAEA implemented the EXFOR database as a relational multiform database and the EXFOR is a trusted, increasing and living database with 19100 experimental works (as of September 2011) and 141600 data tables. The EXFOR provides a compilation control system for selection of articles and compilation of data and the NRDC home page provides manuals, documents and codes. The nuclear data can be retrieved by the web-retrieval system or distributed on a DVD on request. The EXFOR data play a critical role in the development of evaluated nuclear reaction data. There are several major general purpose libraries: ENDF (US), CENDL (China), JEFF (EU), JENDL (Japan) and RUSFOND (Russia). In addition, there are special libraries for particular applications: EAF (European Activation File), FENDL (Fusion Evaluated Nuclear Data Library for ITER neutronics), IBANDL (Ion Beam Analysis Nuclear Data Library for surface analysis of solids), IRDF, DXS (Dosimetry, radiation damage and gas production data) and Medical portal. Dr V. Zerkin of NDS demonstrated the data retrieval from the EXFOR database and the ENDF library.

Experimental (Network) and Evaluated Nuclear Reaction Data at NDS

Energy Technology Data Exchange (ETDEWEB)

Otsuka, N; Semkova, V; Simakov, S P; Zerkin, V [Nuclear Data Services Unit, Nuclear Data Section, IAEA, Vienna (Austria)

2011-11-15

Dr Simakov of Nuclear Data Services Unit in the Nuclear Data Section (NDS) gave a brief overview of the data compilation and evaluation activities in the nuclear data community: experimental nuclear reaction data (EXFOR, http://www-nds.iaea.org/exfor/) and evaluated nuclear reaction data (ENDF, http://www-nds.iaea.org/endf). The International Network of Nuclear Reaction Data Centres (NRDC) coordinated by NDS includes 14 Centres in 8 Countries (China, Hungary, India, Japan, Korea, Russian, Ukraine, USA) and 2 International Organizations (NEA, IAEA). It had the first meeting of four core centres (Brookhaven, Saclay, Obninsk, Vienna) in 1966 and the EXFOR was adopted as an official data exchange format. In 2000, IAEA implemented the EXFOR database as a relational multiform database and the EXFOR is a trusted, increasing and living database with 19100 experimental works (as of September 2011) and 141600 data tables. The EXFOR provides a compilation control system for selection of articles and compilation of data and the NRDC home page provides manuals, documents and codes. The nuclear data can be retrieved by the web-retrieval system or distributed on a DVD on request. The EXFOR data play a critical role in the development of evaluated nuclear reaction data. There are several major general purpose libraries: ENDF (US), CENDL (China), JEFF (EU), JENDL (Japan) and RUSFOND (Russia). In addition, there are special libraries for particular applications: EAF (European Activation File), FENDL (Fusion Evaluated Nuclear Data Library for ITER neutronics), IBANDL (Ion Beam Analysis Nuclear Data Library for surface analysis of solids), IRDF, DXS (Dosimetry, radiation damage and gas production data) and Medical portal. Dr V. Zerkin of NDS demonstrated the data retrieval from the EXFOR database and the ENDF library.

Proceedings of the 4. Brazilian meeting on nuclear applications

International Nuclear Information System (INIS)

1997-01-01

In this proceedings, theoretical and experimental papers were presented covering the following areas: radiation monitoring and dosimetry, nuclear medicine, radiochemistry, environmental sciences, nuclear instrumentation, waste management, industry and mining, medicine and health, agriculture, biology, radioisotopes, hydrology and sediments, irradiators and nuclear reactors

Nuclear Physics Division, Institute of Experimental Physics, Warsaw University Annual Report 1996

Energy Technology Data Exchange (ETDEWEB)

Szeflinski, Z.; Popkiewicz, M. [eds.

1997-12-31

In the presented report the research activities of Nuclear Physics Division (NPD) of the Institute of Experimental Physics (Warsaw University) in year 1996 are described. The report is divided into three parts: Reaction mechanisms and nuclear structure; Experimental methods and instrumentation and the third part contains the list of personnel, seminars held at the Nuclear Physics Division and published papers. A summary of the (NPD) activities are briefly presented in ``Preface`` by NPD director prof. Ch. Droste.

Nuclear Physics Division, Institute of Experimental Physics, Warsaw University annual report 1997

Energy Technology Data Exchange (ETDEWEB)

Szeflinski, Z.; Kirejczyk, M.; Popkiewicz, M. [eds.

1998-08-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Institute of Experimental Physics (Warsaw University) in year 1997 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contain the lists of personnel, seminars held at the Nuclear Physics Division and published papers. A summary of the (NPD) activities are briefly presented in ``Preface`` written by NDP director prof. K. Siwek-Wilczynska

Nuclear Physics Division, Institute of Experimental Physics, Warsaw University annual report 1997

International Nuclear Information System (INIS)

Szeflinski, Z.; Kirejczyk, M.; Popkiewicz, M.

1998-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Institute of Experimental Physics (Warsaw University) in year 1997 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contain the lists of personnel, seminars held at the Nuclear Physics Division and published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' written by NDP director prof. K. Siwek-Wilczynska

Nuclear Physics Division, Institute of Experimental Physics, Warsaw University Annual Report 1996

International Nuclear Information System (INIS)

Szeflinski, Z.; Popkiewicz, M.

1997-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Institute of Experimental Physics (Warsaw University) in year 1996 are described. The report is divided into three parts: Reaction mechanisms and nuclear structure; Experimental methods and instrumentation and the third part contains the list of personnel, seminars held at the Nuclear Physics Division and published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' by NPD director prof. Ch. Droste

Electron optical study of the Venus Express ASPERA-4 Electron Spectrometer (ELS) top-hat electrostatic analyser

International Nuclear Information System (INIS)

Collinson, Glyn A; Kataria, D O; Coates, Andrew J; Tsang, Sharon M E; Arridge, Christopher S; Lewis, Gethyn R; Frahm, Rudy A; Winningham, J David; Barabash, Stas

2009-01-01

The performance of the Venus Express (VEX) ASPERA-4 Electron Spectrometer (ELS) is different from the nominal response shown by the ASPERA-3 ELS aboard Mars Express due to machining tolerance. Up to now, the precise mechanism for this was unknown and, therefore, the results of the experimental calibration could not be supported with a theoretical understanding of the fundamental instrument science behind the device. In this study, we show that the difference is due to a misalignment of the inner hemisphere and a widening of the entrance aperture of the instrument. The response of the VEX ELS can be approximated by a combination of a vertical offset of the inner hemisphere of ≈0.6 mm and a lateral offset of less than 0.125 mm, combined with an aperture that is ≈0.54 mm wider than nominal. The resulting K-factor, geometric factor, energy resolution and peak elevation are in good agreement with those observed experimentally. Therefore, we now have a good agreement between both laboratory calibration data and computer simulation, giving a firm foundation for future scientific data analysis

A Geant4 simulation package for the TASISpec experimental detector setup

Energy Technology Data Exchange (ETDEWEB)

Sarmiento, L.G., E-mail: lgsarmientop@unal.edu.co [Universidad Nacional de Colombia, Bogota D.C. 111321 (Colombia); Lund University, S-22100 Lund (Sweden); Andersson, L.-L. [University of Liverpool, Oliver Lodge Laboratory, Liverpool L69 7ZE (United Kingdom); Rudolph, D. [Lund University, S-22100 Lund (Sweden)

2012-03-01

The experimental detector setup TASISpec (TA SCA in Small Image mode Spectroscopy) comprises composite Ge- and highly segmented Si-detectors. The setup is constructed to provide multi-coincidence spectroscopic data between {gamma}-rays, X-rays, conversion electrons, fission fragments, and {alpha}-particles for heavy and superheavy elements (Z{>=}100). The full array has been virtually constructed using the Geant4 simulation toolkit. The simulations will not only be used to explore the possibilities of the detector setup itself. More important, however, they will also shed light on the nuclear structure of the heaviest elements. This can be done by comparing the simulated detector response of complex decay modes with the experimental data. Such an iterative or 'self-consistent' way to understand experimental observables will provide more reliability when disentangling the data and deducing experimental decay schemes.

The Structure and Content of Agreements between the Agency and States required in connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Estructura y contenido de los acuerdos entre los Estados y el Organismo requeridos en relacion con el Tratado sobre la no proliferacion de las armas nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1971-05-15

The Board of Governors has requested the Director General to use the material reproduced in this booklet as the basis for negotiating safeguards agreements between the Agency and non-nuclear-weapon States party to the Treaty on the Non-Proliferation of Nuclear Weapons [Spanish] El Acuerdo debe contener, de conformidad con el parrafo 1 del Articulo III del Tratado sobre la no proliferacion de las armas nucleares, el compromiso de aceptar salvaguardias por parte del Estado de conformidad con los terminos del Acuerdo, sobre todos los materiales basicos o materiales fisionables especiales en todas las actividades nucleares con fines pacificos realizadas en su territorio, bajo su jurisdiccion, o efectuadas bajo su control en cualquier lugar, a efectos unicamente de verificar que dichos materiales no se desvian hacia armas nucleares u otros dispositivos nucleares explosivos.

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 2003

International Nuclear Information System (INIS)

Kirejczyk, M.; Skwira, I.; Grodner, E.

2004-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 2003 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contain the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' written by NPD director prof. K. Siwek-Wilczynska

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 1998

International Nuclear Information System (INIS)

Kirejczyk, M.; Szeflinski, Z.

1999-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 1998 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contains the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' written by NDP director prof. K. Siwek-Wilczynska

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 2004

International Nuclear Information System (INIS)

Kirejczyk, M.K.

2005-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 2004 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contains the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' written by NDP director prof. K. Siwek-Wilczynska

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 1998

Energy Technology Data Exchange (ETDEWEB)

Kirejczyk, M.; Szeflinski, Z. [eds.

1999-08-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 1998 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contains the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in ``Preface`` written by NDP director prof. K. Siwek-Wilczynska

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 2000

International Nuclear Information System (INIS)

Kirejczyk, M.

2001-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 2000 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contain the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in 'Preface' written by NDP director prof. K. Siwek-Wilczynska

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 2001

International Nuclear Information System (INIS)

Kirejczyk, M.

2001-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 2001 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one which contain the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' written by NPD director prof. K. Siwek-Wilczynska

Nuclear Physics Division - Inst. of Experimental Physics - Warsaw University - Annual Report 1999

International Nuclear Information System (INIS)

Kirejczyk, M.

2000-01-01

In the presented report the research activities of Nuclear Physics Division (NPD) of the Warsaw University Institute of Experimental Physics in year of 1999 are described. The report is divided into three parts: Reaction Mechanisms and Nuclear Structure, Experimental Methods and Instrumentation and the third one contain the lists of personnel, seminars held at the Nuclear Physics Division and list of published papers. A summary of the (NPD) activities are briefly presented in ''Preface'' written by NDP director prof. K. Siwek-Wilczynska

4 puentes sobre el Rin Alemania Federal

Directory of Open Access Journals (Sweden)

Idelberger, Klaus

1978-05-01

Full Text Available This article describes two different ways of carrying out expansion of the number of lanes, from 4 to 6, on a bridge, without having to interrupt traffic: — The bridge with lanes for metropolitan train-trolley and automobiles between the city of Cologne-Deutz (Deutz and Mülheim are very large outskirts of Cologne, to the east of the Rhine, will be expanded between 1977 and 1979 from 4 to 6 lanes by means of an adjacent bridge of similar characteristics. — Another bridge —the suspension bridge for both metropolitan train-trolley and vehicles— existing between Cologne-Riehl and Cologne-Mülheim was expanded between 1974 and 1977 from 4 to 6 lanes of traffic, distributing in a more favorable manner the transversal section with the existing support structure. At the same time the upper part of the bridge was newly paved and reinforced to adapt to the strictest construction standards, in order to avoid future bulging problems.

Se describen en este artículo dos maneras diferentes de realizar la ampliación del número de carriles —de 4 a 6— de los puentes, sin necesidad de interrumpir el tráfico. — El puente de vigas mixtas para tranvía-ferrocarril metropolitano y automóviles entre la ciudad de Colonia-Deutz (Deutz y Mülheim son grandes barrios de Colonia, al este del Rin se ampliará entre los años 1977 y 1979 de 4 a 6 carriles de circulación por medio de uno adyacente de características similares. — Otro puente —el puente colgante para tranvía-ferrocarril metropolitano y vehículos— existente entre Colonia-Riehl y Colonia-Mülheim se amplió entre los años 1974 y 1977 de 4 a 6 carriles de circulación, distribuyendo de modo más favorable la sección transversal con la estructura portante existente. Al mismo tiempo se asfaltó nuevamente la parte superior del puente y se reforzó adaptándose a las normas de construcción más estrictas, con el fin de evitar en el futuro problemas de abolladura.

El cine experimental de mujeres: antecedentes y desarrollo del cine teórico feminista de los 70 en el Reino Unido

Directory of Open Access Journals (Sweden)

Pérez Ríu, Carmen

2012-12-01

Full Text Available This article analyses experimental films made by women between 1920 and 1979, focusing particularly on films produced during the 1970s in the UK and their links to feminist film theory. The first part deals with the participation of women in the experimental film movements from the 1920s to the 1970s. The aim of this section is to provide a context for British experimental women directors during the 1970s within the more complex background of experimental film movements, with influences from the nerve centre of the Avant- Garde in Europe and the USA. The second part studies the development of experimental feminist film in the UK during the 1970s, with special attention to two essential filmmakers, Laura Mulvey and Sally Potter. The article concludes with a discussion of some general characteristics of experimental films by women.

Este artículo analiza la obra experimental de mujeres centrándose principalmente en la que se produjo durante los años 70 en el Reino Unido y su vinculación con la teoría cinematográfica feminista. La primera parte hace un recorrido por la participación de las mujeres en las diferentes corrientes y movimientos del cine experimental desde la década de los 20 hasta los 70. Esta sección tiene como finalidad situar a las directoras experimentales británicas de los 70 dentro de un panorama global mucho más complejo incluyendo las influencias que recibían desde Europa y EE.UU., donde se encontraba el centro neurálgico de las corrientes cinematográficas de vanguardia. Una segunda parte estudia con más detenimiento el fenómeno del cine experimental feminista en Inglaterra durante la década de los 70, con atención especial a las dos cineastas fundamentales de este fenómeno: Laura Mulvey y Sally Potter. A modo de conclusión se incluyen unas características generales del cine experimental de mujeres.

Development of remote welding technology for nuclear fuel end capping (A study on the weldability of Zircaloy-4)

Energy Technology Data Exchange (ETDEWEB)

Kho, Jin Hyun; Sung, Ho Hyun; Hyun, Yong Kyu; Suh, Hee Kang [Korea University of Technology and Education, Cheonan (Korea)

1998-03-01

The integrity of nuclear fuel end cap welds is essential to the nuclear fuel performance and safety as well as the usability of power plant. The first aim of this project is to obtain experimental data on the nuclear fuel cladding materials of Zircaloy-4 with welding processes such as plasma arc, gas tungsten arc and laser beam welding. the data obtained in this study will be applicable to the nuclear fuel design, fabrication and nuclear fuel quality control. In addition, the welding processes applicable to the Zircaloy-4 welding were compared and contrasted. The weldability of Zircaloy-4 was evaluated from the metallurgical and mechanical standpoints. 88 refs., 57 figs., 16 tabs. (Author)

El papel de las nanopartículas en la calcificación arterial: modelo experimental en el conejo

OpenAIRE

Cenizo Revuelta, Noelia

2012-01-01

La etiopatogenia de la calcificación arterial continúa siendo desconocida. El objetivo es comprobar si la administración de nanopartículas calcificantes contribuiría a producir calcificación y agravar del pronóstico de las lesiones arteriales, y si el efecto es frenado por Atorvastatina. Se diseñó un modelo experimental de daño intimal. Animales divididos en 3 grupos: Grupo-A placebo; Grupo-B expuesto a nanopartículas; Grupo-C, expuesto a nanopartículas y Atorvastatina. Análisis tra...

Cultura tecnológico-política sectorial en contexto semiperiférico: el desarrollo nuclear en la Argentina (1945-1994)

OpenAIRE

Hurtado, Diego

2012-01-01

A partir de la caracterización de la Argentina como país semiperiférico, el presente trabajo analiza la conformación de una "cultura nuclear" y de un "régimen tecnopolítico nuclear" -definido por la búsqueda de la autonomía tecnológica y el liderazgo regional y por la promoción de una industria nuclear nacional- que tuvieron como epicentro institucional a la Comisión Nacional de Energía Atómica y mantuvieron su vigencia hasta comienzos de los años noventa. El artículo se enfoca en tres ejes: ...

Modelo 4mat y su influencia en el aprendizaje del inglés, Jesús María - 2014

OpenAIRE

Muñoz Zabaleta, Rósula

2015-01-01

El objetivo de la investigación fue Determinar la relación que existe entre el modelo 4mat y el aprendizaje de inglés en los estudiantes de la Escuela Profesional de Ingeniería de la Universidad Alas Peruanas - Jesús María 2014. Consistió en una investigación básica, desarrollada como un diseño no experimental de nivel correlacional, en una muestra igual a 133 conformada por estudiantes del cursos de inglés I, de las secciones I, II, III de las Escuelas de Ingenierías y Arqu...

Construcción de una instalación experimental para el estudio de los microcontroladores en la Ingeniería Eléctrica

Directory of Open Access Journals (Sweden)

Yoel Rosales Hernández

2011-02-01

Full Text Available Este artículo expone las características técnicas fundamentales del diseño y construcción deuna instalación experimental para la ejecución y el desarrollo de nuevas prácticas delaboratorio de la asignatura de Microprocesadores II, en la Ingeniería Eléctrica.  This paper exposes the fundamental technical characteristics of the design and constructionof an experimental installation for the execution and the development of new practices oflaboratory of the subject of Microprocessors II, in the Electric engineering.

CFD for Nuclear Reactor Safety Applications (CFD4NRS-4) - Workshop Proceedings

International Nuclear Information System (INIS)

2014-01-01

Following the CFD4NRS workshops held in Garching, Germany (Sept. 2006), Grenoble, France (Sep. 2008) and Washington D.C., USA (Sept. 2010), this Workshop is intended to extend the forum created for numerical analysts and experimentalists to exchange information in the application of CFD and CMFD to NRS issues and in guiding nuclear reactor design thinking. The workshop includes single-phase and multi-phase CFD applications, and offers the opportunity to present new experimental data for CFD validation. More emphasis has been given to the experiments, especially on two-phase flow, for advanced CMFD modelling for which sophisticated measurement techniques are required. Understanding of the physics has been depen before starting numerical analysis. Single-phase and multi-phase CFD simulations with a focus on validation were performed in areas such as: single-phase heat transfer, boiling flows, free-surface flows, direct contact condensation and turbulent mixing. These relate to NRS-relevant issues, such as pressurised thermal shock, critical heat flux, pool heat exchangers, boron dilution, hydrogen distribution in containments, thermal striping, etc. The use of systematic error quantification and the application of BPGs were strongly encouraged. Experiments providing data suitable for CFD or CMFD validation were also presented. These included local measurements using multi-sensor probes, laser-based techniques (LDV, PIV or LIF), hot-film/wire anemometry, imaging, or other advanced measuring techniques. There were over 150 registered participants at the CFD4NRS-4 workshop. The programme consisted of 48 technical papers. Of these, 44 were presented orally and 4 as posters. An additional 8 posters related to the OECD/NEA-KAERI sponsored CFD benchmark exercise on turbulent mixing in a rod bundle with spacers (MATiS-H) were presented and a special session was allocated for 6 video presentations. In addition, five keynote lectures were given by distinguished experts. The

Experimental study of water flow in nuclear fuel elements; Estudo experimental do escoamento de agua em elementos combustiveis nucleares

Energy Technology Data Exchange (ETDEWEB)

Rodrigues, Lorena Escriche, E-mail: ler@cdtn.br [Centro Federal de Educacao Tecnologica de Minas Gerais (CEFET), Belo Horizonte, MG (Brazil); Rezende, Hugo Cesar; Mattos, Joao Roberto Loureiro de; Barros Filho, Jose Afonso; Santos, Andre Augusto Campagnole dos, E-mail: hcr@cdtn.br, E-mail: jrmattos@cdtn.br, E-mail: jabf@cdtn.br, E-mail: aacs@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

2013-07-01

This work aims to develop an experimental methodology for investigating the water flow through rod bundles after spacer grids of nuclear fuel elements of PWR type reactors. Speed profiles, with the device LDV (Laser Doppler Velocimetry), and the pressure drop between two sockets located before and after the spacer grid, using pressure transducers were measured.

Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

The Text of the Agreement between Belgium, Denmark, the Federal Republic of Germany, Ireland, Italy, Luxembourg, The Netherlands, the European Atomic Energy Community and the Agency in Connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Texto del Acuerdo Concertado Entre Belgica, Dinamarca, La Republica Federal De Alemania, Irlanda, Italia, Luxemburgo, Los Paises Bajos, La Comunidad Europea De Energia Ato Mica Y El Organismo En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1973-09-14

The text of the Agreement, and of the Protocol thereto, between Belgium, Denmark, the Federal Republic of Germany, Ireland, Italy, Luxembourg, The Netherlands, the European Atomic Energy Community and the Agency in implementation of Article III (1) and (4) of the Treaty on the Non-Proliferation of Nuclear Weapons (reproduced in document INFCIRC/140) is reproduced in this document for the information of all Members [Spanish] Para informacion de todos los Estados Miembros, en el presente documento se transcribe el texto del Acuerdo concertado entre Belgica, Dinamarca, la Republica Federal de Alemania, Irlanda, Italia, Luxemburgo, los Paises Bajos, la Comunidad Europea de Energia Atomica y el Organismo en ejecucion de lo dispuesto en los parrafos 1 y 4 del articulo III del Tratado sobre la no proliferacion de las armas nucleares, asi como el del Protocolo que acompana a dicho Acuerdo.

Blowing loop in the EL-4 reactor: CO{sub 2} flow control analogue study; Boucle de soufflage de la centrale EL-4 - regulation du debit CO{sub 2} - etude analogique

Energy Technology Data Exchange (ETDEWEB)

Chazal, G; Merle, J P; Guillemard, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Leroy, C; Robin, L; Jacquin, J C; Cornudet, A [Societe INDATOM, France (France)

1966-07-01

This report describes one study which contributed to the construction of the Monts d'Arree nuclear power station: EL-4. The reactor is cooled by a CO{sub 2} current provided by 3 turbo-blower groups. The priming vapour for the turbines is taken at the exit of the main CO{sub 2} - H{sub 2}O exchangers. The operation of EL 4 is based on a high degree of centralization of the controls which attributes an important role to the general regulation circuits. This general regulation includes in particular an internal blowing loop which controls the CO{sub 2} flow. The study of the control of this CO{sub 2} flow is made up of 3 parts: - analogue representation of the reactors cooling circuit and of the turbo blower unit. - first test campaign using the analogue computer describing the natural behaviour of the system in the absence of control. theoretical determination of the regulation factors; definition of the regulation using an analogue computer and second test campaign for recording the performances of the blowing loop. The 4. part of the report deals with the analogue study: analogue equations - development. (authors) [French] Ce rapport prend place parmi les etudes de realisation de la Centrale des Monts d'Arree EL-4. Le reacteur est refroidi par une circulation de CO{sub 2} assuree par 3 groupes turbosoufflantes. La vapeur d'entrainement des turbines est prelevee a la sortie des echangeurs principaux CO{sub 2} - H{sub 2}O. L'exploitation de EL-4 repose sur une centralisation poussee des moyens de controle-commande qui attribue un role essentiel aux circuits de regulation generale. Cette regulation generale comporte en particulier une boucle interne de soufflage qui realise un asservissement du debit de CO{sub 2}. L'etude de cette regulation du debit CO{sub 2} comprend 3 parties: - representation analogique du circuit de refroidissement du reacteur et de l'ensemble turbine-soufflante. - premiere campagne d'essais sur calculateur analogique decrivant le comportement

Progress of experimental research on nuclear safety in NPIC

Energy Technology Data Exchange (ETDEWEB)

Gong, Houjun; Zan, Yuanfeng; Peng, Chuanxin; Xi, Zhao; Zhang, Zhen; Wang, Ying; He, Yanqiu; Huang, Yanping [Nuclear Power Institute of China, Chengdu (China)

2016-05-15

Two kinds of Generation III commercial nuclear power plants have been developed in CNNC (China National Nuclear Corporation), one is a small modular reactor ACP100 having an equivalent electric power 100 MW, and the other is HPR1000 (once named ACP1000) having an equivalent electric power 1 000 MW. Both NPPs widely adopted the design philosophy of advanced passive safety systems and considered the lessons from Fukushima Daichi nuclear accident. As the backbone of the R and D of ACP100 and HPR1000, NPIC (Nuclear power Institute of China) has finished the engineering verification test of main safety systems, including passive residual heat removal experiments, reactor cavity injection experiments, hydrogen combustion experiments, and passive autocatalytic recombiner experiments. Above experimental work conducted in NPIC and further research plan of nuclear safety are introduced in this paper.

ESTRUCTURA TRIDIMENSIONAL DE LA CITOQUININA N-BENZIL 9 (2 TETRAHIDROPIRANYL ADENINE UTILIZANDO EL MÉTODO DE RESONANCIA MAGNÉTICA NUCLEAR

Directory of Open Access Journals (Sweden)

Carlos Rojas

2004-06-01

Full Text Available Para comprender la función biológica de las moléculas que conforman los seres vivos es necesario conocer la estructura tridimensional de ellas, pues está comprobado que la función depende más de la distribución espacial que de los mismos componentes. El objetivo del presente trabajo es determinar la estructura de una fitohormona. Uno de los métodos que existen para determinar estas estructuras es la resonancia magnética nuclear pulsada el cual se escogió para este trabajo. Este método se diferencia de la resonancia de onda continua en el hecho de que el campo magnético variable es aplicado en forma de pulsos y su amplitud no puede ser considerada como una perturbación al sistema. La determinación de la estructura exigió la toma de los espectros unidimensionales de H1, C13 y los Distortionless Enhacement by Polarization Transfer (DEPT; este último es una secuencia de pulsos que permite diferenciar entre carbonos unidos a tres, a dos y a un hidrógeno. Con la ayuda del espectro C13 también se pueden distinguir los carbonos que no están enlazados con ningún hidrógeno. Además de éstos, fueron necesarios los siguientes espectros bidimensionales: 1 Heteronuclear Multiple Quantum Correlation (HMQC el cual correlaciona hidrógenos con carbonos que se encuentren enlazados; 2 Heteronuclear Multiple Bond Correlation (HMBC que correlaciona carbonos con hidrógenos que se encuentren a dos o tres enlaces; 3 Correlation Spectroscopy (COSY el cual muestra la correlación entre hidrógenos que se encuentren a dos o tres enlaces; y 4 Nuclear Overhauser Effect Spectroscopy (NOESY el cual correlaciona hidrógenos que distan entre sí menos de 5 Å. A partir de la información obtenida del análisis de estos espectros se dedujo el modelo de la fitohormona que se presenta como resultado del trabajo.

The ATC, the centralized temporary storage facility for the spanish nuclear spend fuel; El ATC, la instalación de Almacenamiento Temporal Centralizado de Combustible Nuclear Gastado Español

Energy Technology Data Exchange (ETDEWEB)

González Fernández-Conde, A.; Gónzalez Gandal, R.; Larrosa Peruga, O.; Medinilla Téllez, G.; Navarro Santos, M.

2016-07-01

The ATC, strategic project contained in the Sixth Radioactive Waste General Plan approved by the Government in 2006, is the temporary storage facility of centralized nature intended to store the spent nuclear fuel generated by Spanish NPP during their operation life, for other so-called special waste arising either from the ATC operation itself or from NPP dismantling, and for vitrified waste generated as a result of fuel reprocessing from Vandellós 1 NPP. The main functions of the ATC are the reception of transport casks, encapsulation of spent fuel, and storage of such canister in dry vaults with passive cooling by natural convection; and additionally, the temporary storage of storage casks with spent fuel, of other special waste in canisters, and finally of secondary waste generated during the operation of the facility. The facility estimated operation lifetime is 60 years, and its safety structures, systems and components are designed considering the requirements according to the Spanish nuclear regulations and using best international practices. In the detailed design, major Spanish and some foreign nuclear sector engineering companies are taking part. [Spanish] El ATC, proyecto estratégico recogido en el Sexto Plan General de Residuos Radiactivos aprobado por el Gobierno en 2006, es la instalación de almacenamiento temporal de carácter centralizado destinada para el combustible nuclear gastado generado por las centrales nucleares españolas durante su proceso de operación, así como de otros residuos denominados especiales originados por la propia operación o durante el desmantelamiento de las citadas centrales nucleares, así como los residuos vitrificados originados como consecuencia del reproceso del combustible de la central nuclear de Vandellós I. Las principales funciones del ATC son la recepción de los contenedores de transporte, encapsulado del combustible y almacenamiento de dichas cápsulas en bóvedas en seco con refrigeración pasiva por

The Text of the Agreement between Iran and the Agency for the Application of Safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Texto Del Acuerdo Concertado Entre El Iran Y El Organismo Para La Aplicacion De Salvaguardias En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1974-12-17

The text of the agreement between Iran and the Agency for the application of safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons is reproduced in this document for the information of all Members [Spanish] Para informacion de todos los Estados Miembros, en el presente documento se trans cribe el texto del Acuerdo concertado entre el Iran y el Organismo para la aplicacion de salvaguardias en relacion con el Tratado sobre la no proliferacion de las armas nucle ares.

El modelo experimental en la enseñanza de la medicina en el v semestre The Experimental Teaching Model in the 5th Semester of Medicine

Directory of Open Access Journals (Sweden)

María Elena de la Uz Herrera

2007-09-01

Full Text Available Se realizó un análisis de los resultados del proceso docente-educativo en la asignatura Propedéutica Clínica y Semiología Médica del V Semestre de la Carrera de Medicina en los estudiantes del Modelo Experimental de Enseñanza, en el actual curso académico. La muestra estuvo constituida por los estudiantes que integran el grupo experimental de enseñanza, insertados en el Proyecto Policlínico Universitario (PPU. Los resultados académicos fueron satisfactorios, con un comportamiento similar a los restantes modelos de enseñanza. La valoración del proceso docente educativo fue considerada de Buena por la mayoría de los estudiantes (60,5 y el 92.1 %de ellos evaluaron positivamenteel papel desempeñado por los profesores integrales (tutores durante este proceso. Se plantearon dificultades con la calidad de algunos medios de enseñanza (Tele clases, así como falta de tiempo para la auto- preparación de los profesores integrales. No obstante, la aplicación de este nuevo modelo revoluciona la enseñanza actual por la introducción de nuevas Formas de Organización de la Enseñanza (FOE, la enseñanza tutorial y el uso de Tecnologías de la Información Científico Técnica (TIC´s, prometiendo un futuro esperanzador hacia la excelencia en la formación médica y profesional que demanda la sociedad contemporánea.The results of the teaching - educative process of Clinical Propedeutics and Medical Semiology in the 5th Semester of Medicine in students of the Teaching Experimental Model in the present academic year were analyzed, the academic results were similarly satisfactory to those of the other teaching models. The assessment of the educative teaching process was considered good by most of the students (60,5 and 92,5% of them evaluated positively the role played by the Comprehensive Professors (Tutors during this process. The difficulties found with the quality of some teaching aids (classes by TV as well as the short time for the

El ferrocarril colombiano: 4 temas recurrentes en la literatura

Directory of Open Access Journals (Sweden)

Luis Márquez

2017-04-01

Full Text Available El objetivo de este trabajo es identificar qué se ha investigado sobre el ferrocarril colombiano y qué temas deberían ser objeto de estudio para comprender mejor el futuro del transporte de carga por ferrocarril en Colombia. El trabajo está basado en una revisión descriptiva de la literatura que permitió identificar 4 temas recurrentes sobre el ferrocarril colombiano: los problemas administrativos del Estado, la competencia con el modo carretero, el transporte del carbón y algunos elementos técnicos como el trazado, la capacidad ferroviaria, la eficiencia, la integración modal y la modelación del transporte. Además de la revisión, que es de gran valor para los tomadores de decisiones sobre comercio internacional, política económica y economía regional, son identificadas temáticas de investigación futura.

LEW 88180, LEW 87119, and ALH 85119: New EH6, EL7, and EL4 Enstatite Chondrites

Science.gov (United States)

Zhang, Y.; Benoit, P. H.; Sears, D. W. G.

1993-07-01

The EH and EL chondrites formed in a uniquely reducing environment, containing low-Fe pyroxene, abundant metal, and a number of unusual sulphides and other minerals [1]. An important aspect of their history is that while the EL chondrites consist predominantly of metamorphosed meteorites, the EH consist primarily of little-metamorphosed meteorites (e.g., [2]), and yet EL chondrites have lower equilibrium temperatures than EH chondrite [3,4]. To help understand this observation and its implication for the history of the classes, we have been searching for new enstatite chondrites, looking especially for meteorites of previously unknown chemical-petrologic class. Using our normal INAA methods [5] and sample splits of 100-200 mg, the bulk composition of nine Antarctic enstatite chondrites and one fall were determined. The data were used to assign the meteorites to chemical classes, the Ni/Ir vs. Al/V plot (Fig. 1) being especially useful since it uses the refractory element difference between EH and EL chondrites and is insensitive to metal-silicate heterogeneity. The well-analyzed Qingzhen was included to check our method. ALH84170, ALH84206, and EET87746, which Mason described as E3, E4, and E4 were all found to be EH chondrites [6]. Our data for the three paired EL3 chondrites were discussed earlier (MAC88136, 88180, and 88184) [7,8]. LEW88180, LEW87119, and ALH85119, which Mason described as type E6, E6, and E4 respectively [6], are EH, EL, and EL; thus LEW88180 and ALH85119 appear to be the first EH6 and EL4 chondrites. The compositions of kamacite, phosphide, and niningerite-alabandite (Fig. 2) for ALH84170, ALH84206, EET87746, LEW88180, and ALH85119 are consistent with Mason's petrologic type assignments [6]. The mineral composition of LEW88180 (2.7% Si and 9.4% Ni in the kamacite, 7.8% Ni in the phosphide, and 60% FeS in the niningerite) confirms our classification of this meteorite as EH6. ALH85119 contains kamacite with 0.5% Si and 7% Ni, phosphide with 46

El delicado caso de la cooperación internacional en materia nuclear El éxito de la cooperación argentino-brasileña

OpenAIRE

Gazze, Patricio Eduardo

2013-01-01

Este artículo analiza el surgimiento de la tecnología nuclear y su influencia en la arena internacional. Estudia en especial el impacto que las aplicaciones bélicas de dicha tecnología provocaron en las Relaciones Internacionales a partir de su trágico debut en Hiroshima y Nagasaki, y su posterior protagonismo en la llamada “guerra fría”. Luego se describen los principales esfuerzos cooperativos de la co...

Experimental Nuclear Physics Activity in Italy

Science.gov (United States)

Chiavassa, E.; de Marco, N.

2003-04-01

The experimental Nuclear Physics activity of the Italian researchers is briefly reviewed. The experiments, that are financially supported by the INFN, are done in strict collaboration by more than 500 INFN and University researchers. The experiments cover all the most important field of the modern Nuclear Physics with probes extremely different in energy and interactions. Researches are done in all the four National Laboratories of the INFN even if there is a deeper involvement of the two national laboratories expressly dedicated to Nuclear Physics: the LNL (Laboratorio Nazionale di Legnaro) and LNS (Laboratorio Nazionale del Sud) where nuclear spectroscopy and reaction dynamics are investigated. All the activities with electromagnetic probes develops in abroad laboratories as TJNAF, DESY, MAMI, ESFR and are dedicated to the studies of the spin physics and of the nucleon resonance; hypernuclear and kaon physics is investigated at LNF. A strong community of researchers work in the relativistic and ultra-relativistic heavy ions field in particular at CERN with the SPS Pb beam and in the construction of the ALICE detector for heavy-ion physics at the LHC collider. Experiments of astrophysical interest are done with ions of very low energy; in particular the LUNA accelerator facility at LNGS (Laboratorio Nazionale del Gran Sasso) succeeded measuring cross section at solar energies, below or near the solar Gamow peak. Interdisciplinary researches on anti-hydrogen atom spectroscopy and on measurements of neutron cross sections of interest for ADS development are also supported.

Applications of computer simulation, nuclear reactions and elastic scattering to surface analysis of materials

Directory of Open Access Journals (Sweden)

Pacheco de Carvalho, J. A.

2008-08-01

Full Text Available This article involves computer simulation and surface analysis by nuclear techniques, which are non-destructive. Both the “energy method of analysis” for nuclear reactions and elastic scattering are used. Energy spectra are computer simulated and compared with experimental data, giving target composition and concentration profile information. The method is successfully applied to thick flat targets of graphite, quartz and sapphire and targets containing thin films of aluminium oxide. Depth profiles of ¹²C and ¹⁶O nuclei are determined using (d,p and (d,α deuteron induced reactions. Rutherford and resonance elastic scattering of (⁴He+ ions are also used.

Este artículo trata de simulación por ordenador y del análisis de superficies mediante técnicas nucleares, que son no destructivas. Se usa el “método de análisis en energia” para reacciones nucleares, así como el de difusión elástica. Se simulan en ordenador espectros en energía que se comparan com datos experimentales, de lo que resulta la obención de información sobre la composición y los perfiles de concentración de la muestra. Este método se aplica con éxito em muestras espesas y planas de grafito, cuarzo y zafiro y muestras conteniendo películas finas de óxido de aluminio. Se calculan perfiles en profundidad de núcleos de ¹²C y de ¹⁶O a través de reacciones (d,p y (d,α inducidas por deuterones. Se utiliza también la difusión elástica de iones (⁴He+, tanto a Rutherford como resonante.

Differential Expression of Ccn4 and Other Genes Between Metastatic and Non-metastatic EL4 Mouse Lymphoma Cells

OpenAIRE

S. CHAHAL, MANPREET; TERESA KU, H.; ZHANG, ZHIHONG; M. LEGASPI, CHRISTIAN; LUO, ANGELA; M. HOPKINS, MANDI; E. MEIER, KATHRYN

2016-01-01

Background: Previous work characterized variants of the EL4 murine lymphoma cell line. Some are non-metastatic, and others metastatic, in syngenic mice. In addition, metastatic EL4 cells were stably transfected with phospholipase D2 (PLD2), which further enhanced metastasis. Materials and Methods: Microarray analyses of mRNA expression was performed for non-metastatic, metastatic, and PLD2-expressing metastatic EL4 cells. Results: Many differences were observed between non-metastatic and meta...

Nuclear spectroscopy with Geant4. The superheavy challenge

Science.gov (United States)

Sarmiento, Luis G.

2016-12-01

The simulation toolkit Geant4 was originally developed at CERN for high-energy physics. Over the years it has been established as a swiss army knife not only in particle physics but it has seen an accelerated expansion towards nuclear physics and more recently to medical imaging and γ- and ion- therapy to mention but a handful of new applications. The validity of Geant4 is vast and large across many particles, ions, materials, and physical processes with typically various different models to choose from. Unfortunately, atomic nuclei with atomic number Z > 100 are not properly supported. This is likely due to the rather novelty of the field, its comparably small user base, and scarce evaluated experimental data. To circumvent this situation different workarounds have been used over the years. In this work the simulation toolkit Geant4 will be introduced with its different components and the effort to bring the software to the heavy and superheavy region will be described.

El cambio en la política exterior de Estados Unidos que permitió el desarrollo del uso pacífico de energía nuclear en Argentina

OpenAIRE

Contursi Reynoso, Adrián

2017-01-01

Las bombas atómicas arrojadas sobre Japón no significan sólo el fin de la Segunda Guerra Mundial en 1945. También es el punto de partida para el creciente interés de los países periféricos para obtener dicha tecnología, aunque no desde un enfoque bélico sino como oportunidad de desarrollo. El presente trabajo explora el cambio de la política de cooperación estadounidense en referencia a los conocimientos sobre la energía nuclear y cómo fue la relación de Argentina con Esta...

4+ Dimensional nuclear systems engineering

International Nuclear Information System (INIS)

Suh, Kune Y.

2009-01-01

productivity. VENUS applies the virtual reality (VR) technology in nuclear industry.VR provides an interactive real time motion with sound and tactile and other forms of feedback. Therefore, management and workers are able to comprehend the work process better by visualizing precisely how activities relate to one another, thus reducing conflicting interpretations and communication problems. VENUS comfortably familiarize the public with existing or planned systems. INUUS provides with effective information management and methodology of expression. Information is offered in such varieties as real time data on the spot, result of computational analysis in the process of plant design and information of documents for drawing, just to name the few. INUUS resorts to 3D object oriented methods to efficaciously manage voluminous information with. For example, INUUS can be used as a 3D pre processor for a NPP system analysis code. JANUS extracts the geometric data directly from the CAD files to import to multidimensional computational fluid and structural dynamics codes. JANUS uses these joint CAD analysis methods to eliminate the necessity of any pre- and post processors. EURUS combines the VR technology with a wide spectrum of high precision, high resolution analysis techniques and virtual design development environment so that a system can be designed and analysed in the cyber space. EURUS realizes cyber experimentation with which the behaviour of such complex structures as NPP can be simulated and reflected onto the design. The 4 + D Technology TM is slated to bring about revolutionary change in improving the NPP life cycle starting from the conceptual design all the way to the final decommissioning. It will also eventually lead to paperless design and paperless plants in the foreseeable future

Actions needed for RA reactor exploitation - I-IV, Part II, Design project VI-SA 1, Experimental loop for testing the EL-4 reactor fuel elements in the central vertical experimental channel of the RA reactor in Vinca; Radovi za potrebe eksploatacije reaktora RA - I-IV, II Deo, Predprojekat VI-SA 1, Petlja za ispitivanje gorivnih elemenata reaktora EL-4 u centralnom vertikalnom eksperimentalnom kanalu reaktora RA u Vinci

Energy Technology Data Exchange (ETDEWEB)

Novakovic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

1961-12-15

The objective of installing the VISA-1 loop was testing the fuel elements of the EL-4 reactor. The fuel elements planned for testing are natural UO{sub 2} with beryllium cladding, cooled by CO{sub 2} under nominal pressure of 60 at and temperature 600 deg C. central vertical experimental channel of the RA reactor was chosen for installing a test loop cooled by CO{sub 2}. This report contains the detailed design project of the testing loop with the control system and safety analysis of the planned experiment.

Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4.

Science.gov (United States)

Moorman, J P; Bobak, D A; Hahn, C S

1996-06-01

The small G-protein Rho regulates the actin microfilament-dependent cytoskeleton. Exoenzyme C3 of Clostridium botulinum ADP-ribosylates Rho at Asn41, a modification that functionally inactivates Rho. Using a Sindbis virus-based transient gene expression system, we studied the role of Rho in murine EL4 T lymphoma cells. We generated a double subgenomic infectious Sindbis virus (dsSIN:C3) recombinant which expressed C3 in >95% of EL4 cells. This intracellular C3 resulted in modification and inactivation of virtually all endogenous Rho. dsSIN:C3 infection led to the formation of multinucleate cells, likely by inhibiting the actin microfilament-dependent step of cytokinesis. Intriguingly, in spite of the inhibition of cytokinesis, karyokinesis continued, with the result that cells containing a nuclear DNA content as high as 16N (eight nuclei) were observed. In addition, dsSIN:C3-mediated inactivation of Rho was a potent activator of apoptosis in EL4 cells. To discern whether the formation of multinucleate cells was responsible for the activation of apoptosis, 5-fluorouracil (5-FUra) was used to induce cell cycle arrest. As expected, EL4 cells treated with 5-FUra were prevented from forming multinucleate cells upon infection with dsSIN:C3. dsSIN:C3 infection, however, still caused marked apoptosis in 5-FUra-treated cells, indicating that this activation of apoptosis was independent of multinucleate cell formation.

La protección radiológica en la industria nuclear española durante el franquismo, 1939-1975

Directory of Open Access Journals (Sweden)

Alfredo Menéndez-Navarro

2013-09-01

Full Text Available En los debates sobre la controversia nuclear pocas veces se presenta en primera plana la cuestión de la seguridad laboral en las instalaciones radiactivas, históricamente relegada a un segundo plano frente a la atención a los potenciales daños a la población general. Con objeto de cubrir parcialmente ese vacío historiográfico, este trabajo se acerca al desarrollo de la protección radiológica laboral en España durante la dictadura del general Franco (1939-1975. Para ello, se repasa el surgimiento de las medidas de protección radiológica en el ámbito internacional y el posterior desarrollo legislativo en el caso español, proceso paralelo al crecimiento del programa nuclear nacional. Finalmente, son exploradas las principales evidencias del impacto de las radiaciones ionizantes sobre la población laboral española.

Reinforcement of planning and response to emergencies inside nuclear power plants; Refuerzo de la planificación y respuesta ante emergencias en el interior de las centrales nucleares

Energy Technology Data Exchange (ETDEWEB)

Cortés, M.A.; Garcés, J.M.; Bolaños, J.; Fernández, J.; Gutiérrez, C.; Pontejo, A.; Rosell, B.

2015-07-01

Fukushima Daichi nuclear accident (11th march of 2011) required a rapid and effective response of nuclear industry, in order to guarantee that current safety margins were enough to cope with events like this or even worse. In Europe, stress tests were carried out to comply with that objective, evaluating if every nuclear plant was able to succeed managing design basis accidents or even beyond. Stress-test results were satisfactory, although several areas for improvement where identified. Improvements in emergency response and management have been developed in several phases. First, increasing emergency response capacity by implementing modifications in existing equipment. Later, installing new equipment (generally portable) which would be used in even more degraded conditions. This must be held by the revision of emergency response personnel and their training. Finally, external support has been reinforced to help in longstanding emergencies, with the establishment of CAE (Regional Center), and collaboration protocols with the Army. These actions, supervised and approved by the Regulator Body (CSN) will lead to increase plants safety margins and their emergency response capacities in order to reduce probability and consequences of a nuclear accident to the minimum. [Spanish] El accidente nuclear ocurrido el 11 de marzo de 2011 en Fukushima Daichi requirió de una pronta y efectiva respuesta de la industria nuclear, que garantizase que los márgenes de seguridad eran los adecuados para hacer frente a sucesos de estas características o incluso peores. Con ese objetivo se planteó, a nivel europeo, la realización de unas pruebas de resistencia que valorasen si las centrales podían hacer frente con garantías a una serie de accidentes dentro y más allá de las bases de diseño. Los resultados fueron satisfactorios, si bien se identificaron varios aspectos de mejora. La mejora en la respuesta y gestión de emergencias de las centrales nucleares se ha planteado en

Parcelas experimentales para el estudio de la erosión hídrica: Finca Experimental La Higueruela

OpenAIRE

Alba, Saturnino de; Benito, Gerardo; Pérez-González, Alfredo

2002-01-01

A continuación se describen el diseño experimental y las instalaciones e instrumentación de las parcelas de erosión hídrica utilizadas en un proyecto de investigación, desarrollado por un equipo de trabajo mixto entre el Centro de Ciencias Medioambientales (CSIC) y el Dpto de Geodinámica de la F. de Geológicas (UCM), para el estudio de la erosión hídrica en campos de agricultura extensiva, en la provincia de Toledo.

Establishment of Experimental Equipment for Training of Professionals in the Nuclear Radiation Measurement

Energy Technology Data Exchange (ETDEWEB)

Ahn, S. K.; Seo, K. W.; Joo, Y. C.; Kim, I. C.; Woo, C. K.; Yoo, B. H. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-09-15

The main purpose of this project is to establish experimental equipment for training of professionals and students in the field of radiation measurement, and settle the foundation for the advanced education system and program. The priority for the experimental equipment had been deduced by reviewing of the Nuclear Training and Education Center of KAERI and other country's training courses. Equipment for training of radiation professionals are High-Purity Germanium spectroscopic systems, alpha analyzers, and hand-held gamma/neutron inspector systems. For the basic experiments, electric personal dosimeters and a reader, radiation survey meters, and various alpha, beta and gamma radiation isotopes have been equipped. Some old or disused equipment and devices were disposed and re-arranged, and a new experiment lab had been settled for gamma spectroscopy. Along with the preparation of equipment, 14 experimental modules have been selected for practical and essential experiments training to professionals from industries, universities and research organizations. Among the modules, 7 important experiment notes had been prepared in Korea and also in English. As a consequence, these advanced radiation experimental setting would be a basis to cooperate with IAEA or other countries for international training courses. These activities would be a foundation for our contribution to the international nuclear society and for improving our nuclear competitiveness. The experimental equipment and application notes developed in this study will be used also by other training institutes and educational organizations through introducing and encouraging to use them to the nuclear society.

Establishment of Experimental Equipment for Training of Professionals in the Nuclear Radiation Measurement

International Nuclear Information System (INIS)

Ahn, S. K.; Seo, K. W.; Joo, Y. C.; Kim, I. C.; Woo, C. K.; Yoo, B. H.

2008-09-01

The main purpose of this project is to establish experimental equipment for training of professionals and students in the field of radiation measurement, and settle the foundation for the advanced education system and program. The priority for the experimental equipment had been deduced by reviewing of the Nuclear Training and Education Center of KAERI and other country's training courses. Equipment for training of radiation professionals are High-Purity Germanium spectroscopic systems, alpha analyzers, and hand-held gamma/neutron inspector systems. For the basic experiments, electric personal dosimeters and a reader, radiation survey meters, and various alpha, beta and gamma radiation isotopes have been equipped. Some old or disused equipment and devices were disposed and re-arranged, and a new experiment lab had been settled for gamma spectroscopy. Along with the preparation of equipment, 14 experimental modules have been selected for practical and essential experiments training to professionals from industries, universities and research organizations. Among the modules, 7 important experiment notes had been prepared in Korea and also in English. As a consequence, these advanced radiation experimental setting would be a basis to cooperate with IAEA or other countries for international training courses. These activities would be a foundation for our contribution to the international nuclear society and for improving our nuclear competitiveness. The experimental equipment and application notes developed in this study will be used also by other training institutes and educational organizations through introducing and encouraging to use them to the nuclear society

Fabrication of the 4. set of fuel elements for the experimental pile EL2

International Nuclear Information System (INIS)

Ringot, C.

1958-01-01

The reactor EL2 is the second atomic reactor built in France. It is a laboratory reactor using heavy water and natural uranium. Its cooling circuit operates with compressed CO 2 gas at 8 kg/cm 2 pressure. The subject of this lecture is the manufacturing of the fourth set of rods. The principle of uranium-can connection is exposed: that is the principle of a pre-pressed bound can. The EL2 reactor has been a prototype with respect to this aspect of the question, and a prototype which has been quite satisfactory. The main steps of the fabrication are exposed: the γ phase extension of uranium, the machining, the three canning (die canning, hydraulic canning, compressed air treatment), the automatic argon arc welding of cups and the different manufacturing controls. (author) [fr

Reactivity measurements on an experimental assembly of 4.31 wt % 235U enriched UO2 fuel rods arranged in a shipping cask geometry

International Nuclear Information System (INIS)

Bierman, S.R.

1989-10-01

A research program was initiated for the US Department of Energy (DOE) Sandia National Laboratory Transportation Systems Development Department in 1982 to provide benchmark type experimental criticality data in support of the design and safe operations of nuclear fuel transportation systems. The overall objective of the program is to identify and provide the experimental data needed to form a consistent, firm, and complete data base for verifying calculational models used in the criticality analyses of nuclear transport and related systems. A report, PNL-6205, issued in June 1988 (Bierman 1988) covered measurement results obtained from a series of experimental assemblies (TIC-1, 2, 3 and 4) involving neutron flux traps. The results obtained on a fifth experimental assembly (TIC-5), modeled after a calculational problem of the Organization for Economic Cooperation and Development (OECD) Nuclear Energy Agency (NEA) Committee on the Safety of Nuclear Installations (CSNI) Working Group, are covered in this report. 10 refs., 10 figs., 7 tabs

Interferon gamma increases survival in urine experimental cryptococcosis El Interferon gamma incrementa la sobrevida de un modelo experimental murino de criptococosis

Directory of Open Access Journals (Sweden)

Amadeo J. Bava

1995-10-01

Full Text Available Systemic disease by Cryptococcus neoformans (C. neoformans is a common opportunistic infection in immunodeficient patients. Cellular immunity seems to be the most important determinant of resistance. The aim of this study was to assess the effect of recombinant rat interferon gamma (IFN-gamma in murine cryptococcosis (Balb/c mice infected by IP route with the Rivas strain of C. neoformans, evaluating survival time, macroscopic and microscopic examination of the organs, and massive seeding of brain homogenate. IFN-gamma treatment, at a daily dose of 10,000 IU, did not modify significantly these variables when mice were challenged with a high inoculum (10(7 yeasts and treatment was delayed to 5 days after infection (median survival 21 days in control mice vs. 23 days in IFN-treated. Another set of experiments suggested that IFN-gamma treatment, at a dose of 10,000 IU/day, begun at the moment of infection could be useful (it prolonged survival from 20 to 28 days, although the difference did not achieve statistical signification. When used simultaneously with infection by 3.5 x 10(5 yeasts, IFN-gamma at 10,000 IU/day for 15 days significantly prolonged survival of mice (p = 0.004. These results suggest that, depending on the experimental conditions, IFN-gamma can improve survival of mice infected with a lethal dose of C. neoformans.Se evaluó la efectividad del interferon-gamma (IFN-gamma recombinante de rata en un modelo experimental de criptococosis desarollado en ratones Balb/C inoculados por vía intraperitoneal con la cepa Rivas de Cryptococcus neoformans (C. neoformans. Se tuvieron en cuenta el tiempo de sobrevida de los animales, el aspecto macroscópico de los órganos en la autopsia, la presencia de levaduras capsuladas en los tejidos y la siembra masiva de un homogenato de cerebro. El tratamiento con IFN-gamma, en dosis diarias de 10.000 UI, no modificó estos parámetros cuando la dosis infectante fue de 10(7 levaduras y el tratamiento se

Completion of the experimental equipment systems and preparation of practical tutorials on the Dalat Nuclear Research Reactor for nuclear science and technology education

International Nuclear Information System (INIS)

Le Vinh Vinh; Huynh Ton Nghiem; Luong Ba Vien; Nguyen Minh Tuan; Nguyen Kien Cuong; Pham Quang Huy; Tran Tri Vien

2015-01-01

The project Completion of the experimental equipment systems and preparation of practical tutorials on the Dalat Nuclear Research Reactor for nuclear science and technology education performed by Dalat Nuclear Research Institute and financed by Ministry of Science and Technology aimed at strengthening the training capability of nuclear human resources. The content of this work includes: i) Improvement of experimental equipment; ii) Compilation of training material for experiments with the improved equipment systems on the reactor; iii) Compilation of training material for reactor calculations includes the following areas: neutronics, hydrothermal, safety analysis and accident consequence analysis. Results of the project provide important conditions to support practical educational and training curriculums in nuclear science and technology. (author)

Overview of experimental research on nuclear structure in department of modern applied physics

International Nuclear Information System (INIS)

Zhu Shengjiang

1999-01-01

The experimental research on nuclear structure in Department of Modern Applied Physics, Tsinghua University has been summarized. The main research results in high spin states of nuclear structure, as well as some low spin states, have been reported

Experimental effects of dynamics and thermodynamics in nuclear reactions on the symmetry energy as seen by the CHIMERA 4 π detector

Energy Technology Data Exchange (ETDEWEB)

De Filippo, E.; Pagano, A. [INFN, Catania (Italy)

2014-02-15

Heavy-ion collisions have been widely used in the last decade to constrain the parameterizations of the symmetry energy term of the nuclear equation of state (EOS) for asymmetric nuclear matter as a function of baryonic density. In the Fermi energy domain one is faced with variations of the density within a narrow range of values around the saturation density ρ{sub 0}=0.16 fm{sup -3} down towards sub-saturation densities. The experimental observables which are sensitive to the symmetry energy are constructed starting from the detected light particles, clusters and heavy fragments that, in heavy-ion collisions, are generally produced by different emission mechanisms at different stages and time scales of the reaction. In this review the effects of dynamics and thermodynamics on the symmetry energy in nuclear reactions are discussed and characterized using an overview of the data taken so far with the CHIMERA multi detector array. (orig.)

Nuclear Physics Division Institute of Experimental Physics Warsaw University annual report 1994

Energy Technology Data Exchange (ETDEWEB)

Osuch, S. [ed.

1995-12-31

In the presented Annual Report the activities of the Nuclear Physics Division of the Institute of Experimental Physics of the Warsaw University in 1994 are described. The report consist of three sections: (i) Reaction Mechanism and Nuclear Structure (12 articles); (ii) Experimental Methods and Instrumentation (2 articles); (iii) Other Research (1 article). Additionally the list of seminars held at the NPD, personnel list and list of published papers is also given. In the first, leading article of the report written by head of NPD prof. Ch. Droste the general description of the Department activity is presented.

Nuclear Physics Division Institute of Experimental Physics Warsaw University annual report 1994

International Nuclear Information System (INIS)

Osuch, S.

1995-01-01

In the presented Annual Report the activities of the Nuclear Physics Division of the Institute of Experimental Physics of the Warsaw University in 1994 are described. The report consist of three sections: i) Reaction Mechanism and Nuclear Structure (12 articles); ii) Experimental Methods and Instrumentation (2 articles); iii) Other Research (1 article). Additionally the list of seminars held at the NPD, personnel list and list of published papers is also given. In the first, leading article of the report written by head of NPD prof. Ch. Droste the general description of the Department activity is presented

Optimizing Nuclear Reaction Analysis (NRA) using Bayesian Experimental Design

International Nuclear Information System (INIS)

Toussaint, Udo von; Schwarz-Selinger, Thomas; Gori, Silvio

2008-01-01

Nuclear Reaction Analysis with 3 He holds the promise to measure Deuterium depth profiles up to large depths. However, the extraction of the depth profile from the measured data is an ill-posed inversion problem. Here we demonstrate how Bayesian Experimental Design can be used to optimize the number of measurements as well as the measurement energies to maximize the information gain. Comparison of the inversion properties of the optimized design with standard settings reveals huge possible gains. Application of the posterior sampling method allows to optimize the experimental settings interactively during the measurement process.

The former experimental nuclear power station in Lucens

International Nuclear Information System (INIS)

Meichle, A.

1989-01-01

In June 1989 in the Swiss canton of Vaud, a majority vote was reached for the discharge from federal responsibility and control of the experimental reactor in Lucens, which was shut down following an accident twenty years ago. As the topic 'Lucens' will remain current interest for some time, a brief history as well as future prospects are presented. The report begins with Switzerland's immediate post-war recognition of the importance of nuclear energy. This was initially characterized by the formation of Reactor Ltd., and three commercial groups. The submission of projects by the latter to parliament in the 1950's for the construction of a test nuclear reactor with the request for federal support met with a positive echo and a subsidy of 50% of the costs. The NGA (a national society for the promotion of industrial nuclear technology) was founded with the aim to consolidate projects into a national plan. The NGA's first step was to plan and install an experimental, heavy water moderated, gas-cooled reactor in Lucens. An engineering group (AGL) was delegated by the NGA to plan, construct and commission the reactor. The construction began in July 1962. The location, type of reactor, fuel used, cooling system and the placement in 3 cavities in a hill are briefly described. In 1966 the reactor first went critical and 2 years later 30 MW thermal power was attained. The construction engineers and the operating management were completely satisfied with reactor operation prior to the accident. 1 fig

Electro and gamma nuclear physics in Geant4

CERN Document Server

Wellisch, J P; Degtyarenko, P V

2003-01-01

Adequate description of electro and gamma nuclear physics is of utmost importance in studies of electron beam-dumps and intense electron beam accelerators. I also is mandatory to describe neutron backgrounds and activation in linear colliders. This physics was elaborated in Geant4 over the last year, and now entered into the stage of practical application. In the {\\sc Geant4} Photo-nuclear data base there are at present about 50 nuclei for which the Photo-nuclear absorption cross sections have been measured. Of these, data on 14 nuclei are used to parametrize the gamma nuclear reaction cross-section The resulting cross section is a complex, factorized function of $A$ and $e = log(E_\\gamma)$, where $E_\\gamma$ is the energy of the incident photon. Electro-nuclear reactions are so closely connected with Photo-nuclear reactions that sometimes they are often called ``Photo-nuclear''. The one-photon exchange mechanism dominates in Electro-nuclear reactions, and the electron can be substituted by a flux of photons. ...

[Establishment and identification of mouse lymphoma cell line EL4 expressing red fluorescent protein].

Science.gov (United States)

Li, Yan-Jie; Cao, Jiang; Chen, Chong; Wang, Dong-Yang; Zeng, Ling-Yu; Pan, Xiu-Ying; Xu, Kai-Lin

2010-02-01

This study was purposed to construct a lentiviral vector encoding red fluorescent protein (DsRed) and transfect DsRed into EL4 cells for establishing mouse leukemia/lymphoma model expressing DsRed. The bicistronic SIN lentiviral transfer plasmid containing the genes encoding neo and internal ribosomal entry site-red fluorescent protein (IRES-DsRed) was constructed. Human embryonic kidney 293FT cells were co-transfected with the three plasmids by liposome method. The viral particles were collected and used to transfect EL4 cells, then the cells were selected by G418. The results showed that the plasmid pXZ208-neo-IRES-DsRed was constructed successfully, and the viral titer reached to 10(6) U/ml. EL4 cells were transfected by the viral solution efficiently. The transfected EL4 cells expressing DsRed survived in the final concentration 600 microg/ml of G418. The expression of DsRed in the transfected EL4 cells was demonstrated by fluorescence microscopy and flow cytometry. In conclusion, the EL4/DsRed cell line was established successfully.

Neutron nuclear data evaluation of cesium isotopes for JENDL-4.0

International Nuclear Information System (INIS)

Iwamoto, Nobuyuki

2011-01-01

For the development of JENDL-4.0, neutron nuclear data for fission product nuclides, 133,134,135,136,137 Cs, were revised in the incident neutron energy range from 1 eV to 20 MeV by using a coupled-channels optical model (OM), and nuclear reaction models. The OM potential parameters were determined for stable 133 Cs to reproduce the experimental data of total and elastic scattering cross sections and angular distributions of elastically scattered neutrons. The present results reasonably reproduce measured data for (n,2n), (n,p), (n,α), and capture reactions on 133 Cs. Important differences between the present results and JENDL-3.3 are found for the capture cross sections of 134,137 Cs. The cross section obtained for 137 Cs was smaller than that in JENDL-3.3. This result makes the transmutation of medium-lived 137 Cs increasingly difficult. The production probabilities of metastable states for 134,138 Cs via capture reactions on 133,137 Cs are compared with experimental values. The present result for 134m Cs production is marginally consistent with measured data. However, a large discrepancy is recognized for 138m Cs production. The γ-ray emission data were evaluated with available measurements, and newly compiled in JENDL-4.0. Maxwellian-averaged capture cross sections were calculated in the energy range from 1 to 10 3 keV, and are compared with other derived data. (author)

Influence of operation of national experimental nuclear reactor on the natural environment

Directory of Open Access Journals (Sweden)

Agnieszka Kaczmarek-Kacprzak

2012-09-01

Full Text Available This paper presents the impact of experimental nuclear reactor operations on the national environment, based on assessment reports of the radiological protection of active nuclear technology sources. Using the analysis of measurements carried out in the last 15 years, the trends are presented in selected elements of the environment on the Świerk Nuclear Centre site and its surroundings. In addition, the impact of research results is presented from the fi fteen year period of environmental analysis on building public confi dence on the eve of the start of construction of the first Polish nuclear power plant.

El papel de la actividad experimental en la enseñanza y aprendizaje del electromagnetismo en la educación superior

Directory of Open Access Journals (Sweden)

Beatriz Elena Osorio Vélez

2015-10-01

Full Text Available Se presentan los resultados del proyecto de investigación: “El papel de la actividad experimental en la enseñanza del electromagnetismo en la educación superior”. Su  objetivo fue diseñar una propuesta de enseñanza del electromagnetismo, basada en la actividad experimental que contribuya con el proceso enseñanza y aprendizaje a nivel universitario.  Para ello se trabajó con un grupo de estudiantes de ingeniería de dos  instituciones de Educación Superior: Institución Universitaria Pascual Bravo y la Universidad de Antioquia. Los estudiantes que hicieron parte de la propuesta, respondieron un cuestionario de cuatro preguntas sobre electromagnetismo.  Las preguntas fueron seleccionadas de acuerdo a investigaciones previas que sobre el mismo tema se realizaron en estudiantes que solamente habían realizado el curso teórico.  Los resultados de este último grupo, evidenció dificultades para explicar fenómenos relacionados con el electromagnetismo, mientras que el grupo de estudiantes que realizó el trabajo experimental, mostró una mejor comprensión del fenómeno, logrando estructurar y organizar sus explicaciones. ABSTRACT The results of the research are presented: "The role of experimental activity in teaching electromagnetics in higher education." Their goal was to design a proposal for teaching electromagnetism, based on the experimental activity that contributes to the teaching and learning process at the university level. To do this, we worked with a group of engineering students from two institutions of higher education: University Pascual Bravo Institute and the University of Antioquia. Students who were part of the proposal, a questionnaire of four questions on electromagnetism. The questions were selected based on previous research on the same topic were conducted in students who had just completed the theoretical course. The results of the latter group showed difficulty explaining phenomena related to

Experimental study of water flow in nuclear fuel elements

International Nuclear Information System (INIS)

Rodrigues, Lorena Escriche; Rezende, Hugo Cesar; Mattos, Joao Roberto Loureiro de; Barros Filho, Jose Afonso; Santos, Andre Augusto Campagnole dos

2013-01-01

This work aims to develop an experimental methodology for investigating the water flow through rod bundles after spacer grids of nuclear fuel elements of PWR type reactors. Speed profiles, with the device LDV (Laser Doppler Velocimetry), and the pressure drop between two sockets located before and after the spacer grid, using pressure transducers were measured

Fabrication of the 4. set of fuel elements for the experimental pile EL2; Fabrication du 4. jeu de barreaux de la pile d'essai EL2

Energy Technology Data Exchange (ETDEWEB)

Ringot, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The reactor EL2 is the second atomic reactor built in France. It is a laboratory reactor using heavy water and natural uranium. Its cooling circuit operates with compressed CO{sub 2} gas at 8 kg/cm{sup 2} pressure. The subject of this lecture is the manufacturing of the fourth set of rods. The principle of uranium-can connection is exposed: that is the principle of a pre-pressed bound can. The EL2 reactor has been a prototype with respect to this aspect of the question, and a prototype which has been quite satisfactory. The main steps of the fabrication are exposed: the {gamma} phase extension of uranium, the machining, the three canning (die canning, hydraulic canning, compressed air treatment), the automatic argon arc welding of cups and the different manufacturing controls. (author) [French] Le reacteur EL2 est le deuxieme reacteur construit en France. C'est un reacteur de recherches qui utilise de l'eau lourde et de l'uranium naturel. Il est refroidi par du gaz carbonique sous 8 kg/cm{sup 2} de pression. On etudie dans cet expose la fabrication du quatrieme jeu d'elements combustibles. Le principe de la liaison uranium-gaine est expose: c'est celui d'une gaine precontrainte. La pile EL2 a constitue un prototype a ce point de vue, prototype qui a donne entiere satisfaction. Les principales etapes de la fabrication sont ensuite expliquees: le filage {gamma} de l'uranium, l'usinage des barreaux, les trois operations de gainages (gainage par filiere, gainage hydraulique, gainage a chaud), la soudure automatique des bouchons a l'argon-arc et les differents controles de fabrication. (auteur)

Dispositivo de posicionamiento de muestras biológicas para su irradiación en un canal radial de un reactor nuclear // Biological samples positioning device for irradiations on a radial channel at the nuclear research reactor

Directory of Open Access Journals (Sweden)

Maritza Rodríguez - Gual

2010-05-01

Full Text Available ResumenPor la demanda de un dispositivo experimental para el posicionamiento de las muestras biológicaspara su irradiación en un canal radial de un reactor nuclear de investigaciones en funcionamiento, seconstruyó y se puso en marcha un dispositivo para la colocación y retirada de las muestras en laposición de irradiación de dicho canal. Se efectuaron las valoraciones económicas comparando conotro tipo de dispositivo con las mismas funciones. Este trabajo formó parte de un proyectointernacional entre Cuba y Brasil que abarcó el estudio de los daños inducidos por diferentes tipos deradiación ionizante en moléculas de ADN. La solución propuesta es comprobada experimentalmente,lo que demuestra la validez práctica del dispositivo. Como resultado del trabajo, el dispositivoexperimental para la irradiación de las muestras biológicas se encuentra instalado y funcionando yapor 5 años en el canal radial # 3(BH#3 Palabras claves: reactor nuclear de investigaciones, dispositivo para posicionamiento de muestras,___________________________________________________________________________AbstractFor the demand of an experimental device for biological samples positioning system for irradiationson a radial channel at the nuclear research reactor in operation was constructed and started up adevice for the place and remove of the biological samples from the irradiation channels withoutinterrupting the operation of the reactor. The economical valuations are effected comparing withanother type of device with the same functions. This work formed part of an international projectbetween Cuba and Brazil that undertook the study of the induced damages by various types ofionizing radiation in DNA molecules. Was experimentally tested the proposed solution, whichdemonstrates the practical validity of the device. As a result of the work, the experimental device forbiological samples irradiations are installed and operating in the radial beam hole #3(BH#3

B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism

OpenAIRE

Stremmel, C.; Greenfield, E.A.; Howard, E.; Freeman, G.J.; Kuchroo, V.K.

1999-01-01

For T cells to become functionally activated they require at least two signals. The B7 costimulatory molecules B7-1 and B7-2 provide the “second signal” pivotal for T cell activation. In this report, we studied the relative roles of B7-1 and B7-2 molecules in the induction of antitumor immunity to the T cell thymoma, EL4. We generated EL4 tumor cells that expressed B7-1, B7-2, and B7-1+B7-2 by transfecting murine cDNAs. Our results demonstrate that EL4–B7-1 cells are completely rejected in sy...

Experimental evidence of independence of nuclear de-channeling length on the particle charge sign

Energy Technology Data Exchange (ETDEWEB)

Bagli, E.; Guidi, V.; Mazzolari, A.; Bandiera, L.; Germogli, G.; Sytov, A.I. [Universita di Ferrara, Dipartimento di Fisica e Scienze della Terra (Italy); INFN Sezione di Ferrara (Italy); De Salvador, D. [Universita di Padova, Dipartimento di Fisica e Astronomia, Padua (Italy); INFN Laboratori Nazionali di Legnaro (Italy); Berra, A.; Prest, M. [Universita dell' Insubria, Como (Italy); INFN Sezione di Milano Bicocca, Milan (Italy); Vallazza, E. [INFN Sezione di Trieste (Italy)

2017-02-15

Under coherent interactions, particles undergo correlated collisions with the crystal lattice and their motion result in confinement in the fields of atomic planes, i.e. particle channeling. Other than coherently interacting with the lattice, particles also suffer incoherent interactions with individual nuclei and may leave their bounded motion, i.e., they de-channel. The latter is the main limiting factor for applications of coherent interactions in crystal-assisted particle steering. We experimentally investigated the nature of de-channeling of 120 GeV/c e{sup -} and e{sup +} in a bent silicon crystal at H4-SPS external line at CERN. We found that while channeling efficiency differs significantly for e{sup -} (2 ± 2%) and e{sup +} (54 ± 2%), their nuclear de-channeling length is comparable, (0.6 ± 0.1) mm for e{sup -} and (0.7 ± 0.3) mm for e{sup +}. The experimental proof of the equality of the nuclear de-channeling length for positrons and electrons is interpreted in terms of similar dynamics undergone by the channeled particles in the field of nuclei irrespective of their charge. (orig.)

Differential downstream functions of protein kinase Ceta and -theta in EL4 mouse thymoma cells.

Science.gov (United States)

Resnick, M S; Kang, B S; Luu, D; Wickham, J T; Sando, J J; Hahn, C S

1998-10-16

Sensitive EL4 mouse thymoma cells (s-EL4) respond to phorbol esters with growth inhibition, adherence to substrate, and production of cytokines including interleukin 2. Since these cells express several of the phorbol ester-sensitive protein kinase C (PKC) isozymes, the function of each isozyme remains unclear. Previous studies demonstrated that s-EL4 cells expressed substantially more PKCeta and PKCtheta than did EL4 cells resistant to phorbol esters (r-EL4). To examine potential roles for PKCeta and PKCtheta in EL4 cells, wild type and constitutively active versions of the isozymes were transiently expressed using a Sindbis virus system. Expression of constitutively active PKCeta, but not PKCtheta, in s- and r-EL4 cells altered cell morphology and cytoskeletal structure in a manner similar to that of phorbol ester treatment, suggesting a role for PKCeta in cytoskeletal organization. Prolonged treatment of s-EL4 cells with phorbol esters results in inhibition of cell cycling along with a decreased expression of most of the PKC isozymes, including PKCtheta. Introduction of virally expressed PKCtheta, but not PKCeta, overcame the inhibitory effects of the prolonged phorbol ester treatment on cell cycle progression, suggesting a possible involvement of PKCtheta in cell cycle regulation. These results support differential functions for PKCeta and PKCtheta in T cell activation.

Comportamiento experimental del Sporothrix schenckii y la Leishmania mexicana en el hamster Experimental behavior of Sporothrix schenckii and Leishmania mexicana in hamsters

Directory of Open Access Journals (Sweden)

Luz Angela González de Polanía

1990-10-01

Full Text Available La descripción macroscópica del proceso de patogénesis en hamsters inoculados subcutáneamente en nariz con Sporothrix schenckii ó Leishmania mexicana spp. proporcionó bases para diferenciar estos dos microorganismos en un modelo animal utilizado comunmente para estudiarlos. Observaciones secuenciales durante 150 días permitieron afirmar que en las infecciones causadas por estos patógenos se presentaron edema y eritema como signos primarios, seguidos de alopecia, necrosis y ulceración. La producción de pus fué una característica distintiva para el S. schenckii. Estos signos clínicos se observaron más temprano en la esporotricosis que en la infección por L. mexicana, mostrando diferencias estadísticas significantes en días promedio de aparición. El presente trabajo muestra que las lesiones producidas tanto por el S. schenckii como la L. mexicana en este modelo experimental comparten signos clínicos, pero el tiempo de aparición de los mismos y su frecuencia relativa permiten diferenciarlas. Las condiciones de inoculación como: cepa de los microorganismos, dosis del inóculo, sitio y vía de inoculación, deben tenerse presentes en la evaluación de su comportamiento experimental.The macroscopic description of the pathogenic process of Sporothrix schenckii and Leishmania mexicana spp in hamsters inoculated subcutaneously in the nose provided bases for the differentiation of the behavior of these two microorganisms in a model frequently utilized for their study. Sequential observations over 150 days demonstrated that infections caused by these pathogens results initially in edema and erythema followed by loss of hair, necrosis and ulceration. The pus production was a characteristic presented only by S. schenckii. These clinical signs were observed earlier in sporotrichosis than in L. mexicana infection. Differences in the mean day of appearance were statistically significant. The lesions produced by S. schenckii and L. mexicana

A novel experimental technique of nuclear lifetime measurements

International Nuclear Information System (INIS)

Yuminov, O.A.; D'Arrigo, A.; Giardina, G.; Taccone, A.; Vannini, G.; Moroni, A.; Ricci, R.A.; Vannucci, L.

1995-01-01

In the present paper a new experimental method to measure nuclear reaction time in the 10 -15 -10 -10 s region is presented. Measurements of the lifetimes of low-lying and long-lived states of 19 F and 20 Ne decaying via α-channel were carried out with the aim of checking the feasibility of the method. The results obtained in this way are compared with the lifetimes known from different techniques. ((orig.))

Experimental nuclear medicine

Energy Technology Data Exchange (ETDEWEB)

Dormehl, I C [Nuclear Development Corp. of South Africa (Pty.) Ltd., Pelindaba, Pretoria. Inst. of Life Sciences; Du Plessis, M; Jacobs, D J

1983-07-01

Exciting investigative research, widening the dimensions of conventional nuclear medicine, is being conducted in Pretoria where the development and evaluation of new radiopharmaceuticals in particular is attracting international attention. Additional to this, the development of new diagnostic techniques involving sophisticated data processing, is helping to place South Africa firmly in the front line of nuclear medical progress.

Experimental investigation into the seismic behavior of nuclear power plant shear wall structures

International Nuclear Information System (INIS)

Kenneally, R.M.; Burns, J.J. Jr.

1988-01-01

Nuclear power plant structures are designed to resist large earthquakes. However, as new data are obtained on earthquake activity throughout the United States, plant design earthquake levels have increased. The U.S. Nuclear Regulatory Commission is sponsoring an analytical-experimental research program to obtain information on the strucutral response of nuclear power plant shear wall strucutres subjected to earthquake motions within and beyond their design basis. Using different size scale models constructed with microconcrete and prototypical concrete this research has demonstrated consistent results for measured values of stiffness at load levels within the design basis. Furthermore, the values are well below the theoretical stiffnesses calculated from an uncracked cross-section strength-of-materials approach. Current program emphasis is to assess the credibility of previous experimental work by beginning to resolve the 'stiffness difference' issue. (orig.)

Experimental Observation of Nuclear Reactions in Palladium and Uranium

International Nuclear Information System (INIS)

J. Dufour; D. Murat; X. Dufour; J. Foos

2001-01-01

By submitting various metals (Pd, U) containing hydrogen (from 2000 to 700 000 atoms of hydrogen for 1 000 000 atoms of the host metal) to the combined action of electrical currents and magnetic fields, we have observed a sizeable exothermal effect (from 0.1 to 8 W for 500 mg of metal used). This effect is beyond experimental errors, the energy output being typically 130 to 250% of the energy input and not of chemical origin (exothermal effect in the range of 7000 MJ/mol of metal in the case of palladium and of 60 MJ/mol in the case of uranium). New chemical species also appear in the processes metals. It has been shown by a QED calculation that resonances of long lifetime (s), nuclear dimensions (fm), and low energy of formation (eV) could exist. This concept seems to look like the 'shrunken hydrogen atoms' proposed by various authors. It is indeed very different in two ways (a) being a metastable state, it needs energy to be formed (a few eV) and reverts to normal hydrogen after a few seconds, liberating back its energy of formation (it is thus not the source of the energy observed); (b) its formation can be described as the electron spin/proton nuclear spin interaction becoming first order in the lattice environment (whereas it is third order in a normal hydrogen atom). Moreover, we consider that the hydrex cannot yield a neutron because this reaction is strongly endothermic. To explain our results, we put forward the following working hypothesis: In a metal lattice and under proper conditions, the formation of such resonances (metastable state) could be favored. We propose to call them HYDREX, and we assume that they are actually formed in cold fusion (CF) and low-energy nuclear reaction (LENR) experiments. Once formed, a number of HYDREX could gather around a nucleus of the lattice to form a cluster of nuclear size and of very long life time compared to nuclear time (10 -22 s). In this cluster, nuclear rearrangements could take place, yielding mainly 4 He

Nuclear receptor 4a3 (nr4a3 regulates murine mast cell responses and granule content.

Directory of Open Access Journals (Sweden)

Gianni Garcia-Faroldi

Full Text Available Nuclear receptor 4a3 (Nr4a3 is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated the functional impact of Nuclear receptor 4a3 on mast cell responses. We show that Nuclear receptor 4a3 is involved in the regulation of cytokine/chemokine secretion in mast cells following activation via the high affinity IgE receptor. Moreover, Nuclear receptor 4a3 negatively affects the transcript and protein levels of mast cell tryptase as well as the mast cell's responsiveness to allergen. Together, these findings identify Nuclear receptor 4a3 as a novel regulator of mast cell function.

Deficient tyrosine phosphorylation of c-Cbl and associated proteins in phorbol ester-resistant EL4 mouse thymoma cells.

Science.gov (United States)

Luo, X; Sando, J J

1997-05-02

Two tyrosine phosphoproteins in phorbol ester-sensitive EL4 (S-EL4) mouse thymoma cells have been identified as the p120 c-Cbl protooncogene product and the p85 subunit of phosphatidylinositol 3-kinase. Tyrosine phosphorylation of p120 and p85 increased rapidly after phorbol ester stimulation. Phorbol ester-resistant EL4 (R-EL4) cells expressed comparable amounts of c-Cbl and phosphatidylinositol 3-kinase protein but greatly diminished tyrosine phosphorylation. Co-immunoprecipitation experiments revealed complexes of c-Cbl with p85, and of p85 with the tyrosine kinase Lck in phorbol ester-stimulated S-EL4 but not in unstimulated S-EL4 or in R-EL4 cells. In vitro binding of c-Cbl with Lck SH2 or SH3 domains was detected in both S-EL4 and R-EL4 cells, suggesting that c-Cbl, p85, and Lck may form a ternary complex. In vitro kinase assays revealed phosphorylation of p85 by Lck only in phorbol ester-stimulated S-EL4 cells. Collectively, these results suggest that Cbl-p85 and Lck-p85 complexes may form in unstimulated S-EL4 and R-EL4 cells but were not detected due to absence of tyrosine phosphorylation of p85. Greatly decreased tyrosine phosphorylation of c-Cbl and p85 in the complexes may contribute to the failure of R-EL4 cells to respond to phorbol ester.

Archival and Dissemination of the U.S. and Canadian Experimental Nuclear Reaction Data (EXFOR Project)

Science.gov (United States)

Pritychenko, Boris; Hlavac, Stanislav; Schwerer, Otto; Zerkin, Viktor

2017-09-01

The Exchange Format (EXFOR) or experimental nuclear reaction database and the associated Web interface provide access to the wealth of low- and intermediate-energy nuclear reaction physics data. This resource includes numerical data sets and bibliographical information for more than 22,000 experiments since the beginning of nuclear science. Analysis of the experimental data sets, recovery and archiving will be discussed. Examples of the recent developments of the data renormalization, uploads and inverse reaction calculations for nuclear science and technology applications will be presented. The EXFOR database, updated monthly, provides an essential support for nuclear data evaluation, application development and research activities. It is publicly available at the National Nuclear Data Center website http://www.nndc.bnl.gov/exfor and the International Atomic Energy Agency mirror site http://www-nds.iaea.org/exfor. This work was sponsored in part by the Office of Nuclear Physics, Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-98CH10886 with Brookha ven Science Associates, LLC.

Summary Report of the Workshop on the Experimental Nuclear Reaction Data Database

International Nuclear Information System (INIS)

Semkova, V.; Pritychenko, B.

2014-12-01

The Workshop on the Experimental Nuclear Reaction Data Database (EXFOR) was held at IAEA Headquarters in Vienna from 6 to 10 October 2014. The workshop was organized to discuss various aspects of the EXFOR compilation process including compilation rules, different techniques for nuclear reaction data measurements, software developments, etc. A summary of the presentations and discussions that took place during the workshop is reported here. (author)

Summary Report of the Workshop on The Experimental Nuclear Reaction Data Database

Energy Technology Data Exchange (ETDEWEB)

Semkova, V. [IAEA Nuclear Data Section, Vienna (Austria); Pritychenko, B. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2014-12-01

The Workshop on the Experimental Nuclear Reaction Data Database (EXFOR) was held at IAEA Headquarters in Vienna from 6 to 10 October 2014. The workshop was organized to discuss various aspects of the EXFOR compilation process including compilation rules, different techniques for nuclear reaction data measurements, software developments, etc. A summary of the presentations and discussions that took place during the workshop is reported here.

Performance of synthetic geo membrane installed in the experimental field of el Saltadero; Comportamiento de geomembranas sinteticas instaladas en el campo experimental de El Saltadero

Energy Technology Data Exchange (ETDEWEB)

Blanco, M.; Aguiar, E.; Vara, Ta.; Garcia, F.; Soriano, J.; Castillo, F.

2009-07-01

El Saltadero is a covered reservoir located in a place of strong insolation in the South of the Island of Tenerife, where and artificial slop has been constructed directed to the south in which some sheets were applied to be used like geo membranes in hydraulic work waterproofing. In this experimental field of research they have been placed perfectly anchored sheets of new materials and other traditional ones, but whose manufacturers were not sufficiently implanted in our country. In all the cases sheets were solded with the aim of showing not only the performance of the geo membranes but their one the joint. Initial tests have been made. besides samples have been taken to determinate their technical properties and to see their evolution as well as behaviour one time installed. considerated materials were PVC, HDPE, CSM, EVA/C, EPDM, PP and polyolefines. Important characteristics were evaluated: tensile properties, tear resistance (in HDPE), yield point (in HDPE), impact resistance, static perforation, low temperature folding, joint strength, joint peel resistance plasticizer content (in PVC-P), carbon black; content and dispersion (in HDPE), optic microscopy and electron microscopy scanner. The most significant results with the different materials from this experimental field are presented an they can be considered pioneer for geo membranes to use in hydraulic work waterproofing. (Author) 29 refs.

Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2.

Science.gov (United States)

Condie, R; Herring, A; Koh, W S; Lee, M; Kaminski, N E

1996-05-31

Cannabinoid receptors negatively regulate adenylate cyclase through a pertussis toxin-sensitive GTP-binding protein. In the present studies, signaling via the adenylate cyclase/cAMP pathway was investigated in the murine thymoma-derived T-cell line, EL4.IL-2. Northern analysis of EL4.IL-2 cells identified the presence of 4-kilobase CB2 but not CB1 receptor-subtype mRNA transcripts. Southern analysis of genomic DNA digests for the CB2 receptor demonstrated identical banding patterns for EL4.IL-2 cells and mouse-derived DNA, both of which were dissimilar to DNA isolated from rat. Treatment of EL4.IL-2 cells with either cannabinol or Delta9-THC disrupted the adenylate cyclase signaling cascade by inhibiting forskolin-stimulated cAMP accumulation which consequently led to a decrease in protein kinase A activity and the binding of transcription factors to a CRE consensus sequence. Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC. Further, cannabinoid treatment also decreased PMA/ionomycin-induced nuclear factor binding to the AP-1 proximal site of the IL-2 promoter. Conversely, forskolin enhanced PMA/ionomycin-induced AP-1 binding. These findings suggest that inhibition of signal transduction via the adenylate cyclase/cAMP pathway induces T-cell dysfunction which leads to a diminution in IL-2 gene transcription.

English Language for Teachers (EL4T): a course for EFL teachers

OpenAIRE

Shrestha, Prithvi

2013-01-01

This paper reports on the design and implementation of EL4T in a large-scale project. EL4T is a self-study mobile technology-based ESP course designed to enhance Bangladeshi school English language teachers’ English language skills and pedagogical practices. Key implications of developing this course for ESP in EFL contexts will be presented.

Experimental study of the pile EL3

International Nuclear Information System (INIS)

1958-01-01

The results of two months' experiments, carried out at low power following the first divergence (4. July 1957) are presented. These experiments dealt with the following points: comparison of experimental and calculated values of the critical size; effects due to the introduction of absorbing materials into the principal experimental facilities, flux distribution measurements especially in these facilities, calibration of safety, control and compensating rods, determination of the average life of the neutrons. (author) [fr

Summary of experimental studies on biological effects of radionuclides in Chinese Nuclear Industry

International Nuclear Information System (INIS)

Chen Rusong

1994-11-01

The experimental studies on the biological effects with internal contamination of radionuclides (Such as Uranium, Plutonium, Tritium, Iodine, Radon and its products, etc.) in the Chinese nuclear industry were summarized systematically. In these studies some institutes in the nuclear industry system and other relevant units in China were involved. The review was carried out in both stochastic and deterministic effects, and focused on the dose-effect relationship. The research work showed that great progress for the experimental studies on biological effects with internal irradiation has been made in China. There is a definite characteristic in a certain extent. It makes contribution to develop the production of nuclear industry and the construction of national economy. Several constructive suggestions of prospects for the work in future were proposed and it will make an attention in the field of radiation protection at home and abroad

Interactions of RuO4(g) with different surfaces in nuclear reactor containments

International Nuclear Information System (INIS)

Holm, J.; Glaenneskog, H.; Ekberg, C.

2008-07-01

During a severe nuclear reactor accident with air ingress, ruthenium in the form of RuO4 can be released from the nuclear fuel. Hence, it is important to investigate how the reactor containment is able to reduce the source term of ruthenium. This work has investigated the distribution of RuO4 between an aqueous and gaseous phase in the temperature interval of 20-50 deg. C by on-line measurements with an experimental set-up made of glass. The experiments showed that RuO4 is almost immediately distributed in the aqueous phase after its introduction in the set-up in the entire temperature interval. However, the deposition of ruthenium on the glass surfaces in the system was significant. The speciation of the ruthenium on the glass surfaces was studied by SEM-EDX and ESCA and was determined to be the expected RuO2. Experiments of interactions between gaseous ruthenium tetroxide and the metals aluminium, copper and zinc have been investigated. The metals were treated by RuO4 (g) at room temperature and analyzed with ESCA, SEM and XRD. The analyses show that the black ruthenium deposits on the metal surfaces were RuO2, i.e. the RuO4 (g) has been transformed on the metal surfaces to RuO2(s). The analyses showed also that there was a significant deposition of ruthenium tetroxide especially on the copper and zinc samples. Aluminium has a lower ability to deposit gaseous ruthenium tetroxide than the other metals. The conclusion that can be made from the results is that surfaces in nuclear reactor containments will likely reduce the source term in the case of a severe accident in a nuclear power plant. (au)

The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor

Energy Technology Data Exchange (ETDEWEB)

Zhou, X. Edward; Suino-Powell, Kelly M.; Xu, Yong; Chan, Cee-Wah; Tanabe, Osamu; Kruse, Schoen W.; Reynolds, Ross; Engel, James Douglas; Xu, H. Eric (Michigan-Med); (Van Andel)

2015-11-30

Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors. Here we report the crystal structure of the ligand-free TR4 ligand binding domain, which reveals an autorepressed conformation. The ligand binding pocket of TR4 is filled by the C-terminal half of helix 10, and the cofactor binding site is occupied by the AF-2 helix, thus preventing ligand-independent activation of the receptor. However, TR4 exhibits constitutive transcriptional activity on multiple promoters, which can be further potentiated by nuclear receptor coactivators. Mutations designed to disrupt cofactor binding, dimerization, or ligand binding substantially reduce the transcriptional activity of this receptor. Importantly, both retinol and retinoic acid are able to promote TR4 to recruit coactivators and to activate a TR4-regulated reporter. These findings demonstrate that TR4 is a ligand-regulated nuclear receptor and suggest that retinoids might have a much wider regulatory role via activation of orphan receptors such as TR4.

Experimental and calculational works on characteristics of the Dalat Nuclear Research Reactor. Second edition

International Nuclear Information System (INIS)

Pham Ngoc Khoi; Nguyen Kim Dung

2016-03-01

Recognizing the significant value and necessity of publishing the scientific document of experimental and calculational works on the Dalat Nuclear Research Reactor (DNRR) physics and engineering for research, operation, training activities as well as for international scientific exchange, Vietnam Atomic Energy Agency (VAEA) and Vietnam Atomic Energy Institute have completed editing to publish the “Experimental and Calculational Works on Characteristics of THE DALAT NUCLEAR RESEARCH REACTOR” which consists of 26 typical papers representing the most important experimental and calculational results of the DNRR physics and engineering obtained during 30 years of operation and exploitation with the contribution of Vietnamese and former USSR’s experts, especially scientists and engineers working at the Reactor Center of the NRI

Criticality Studies in a Pilot Plant for Processing MTR-Type Irradiated Fuels; Estudios de Criticidad de una Planta Piloto para el Tratamiento de Combustibles Irradiados Tipo ' MTR '

Energy Technology Data Exchange (ETDEWEB)

Pereira Sanchez, G.; Uriarte Hueda, A. [Junta de Energia Nuclear, Division de Materiales Madrid (Spain)

1966-05-15

A number of theoretical studies on nuclear safety have been carried out in a pilot plant being constructed at the Junta de Energia Nuclear in Madrid for processing irradiated fuels from the MTR-type experimental reactor JEN-1. The study was carried out working with aqueous and organic solutions at two levels of {sup 235}U enrichment - 20% and 93%. The paper is divided into two main parts: the first deals with the individual items of equipment, and the interactions between these are studied in the second part. The calculations in this second part have been made using three different methods to make it more certain that the system as a whole can never be critical. The first method employed is based on the solid angle concept and makes it possible to fix the maximum {sup 235}U concentrations within the system. The second method, based on the albedo, supplies the value of the multiplication factor K of the whole assembly as a function of the concentration of {sup 235}U. In the last part, the distribution of the equipment is compared with other similar systems and experimental tests from other sources. Finally, the paper specifies the conditions for working the installation which ensure that a nuclear accident can never occur. (author) [Spanish] Se ha efectuado una serie de estudios teoricos sobre la seguridad nuclear de una planta piloto, que se encuentra en construccion en la Junta de Energfa Nuclear situada en Madrid, para el tratamiento de combustibles irradiados procedentes del reactor experimental JEN-1 del tipo MTR. El estudio se ha realizado utilizando disoluciones, tanto acuosas como organicas, con dos grados de enriquecimiento, 20% y 93% en {sup 235}U. Este trabajo comprende dos partes principales: en la primera se han considerado las distintas unidades del equipo individualmente y en la segunda se han estudiado las interacciones entre ellas. El calculo de esta segunda parte se ha hecho por tres metodos diferentes para tener una mayor seguridad de que el

Influencia del solvente en el espectro ultravioleta del 4-nitrobifenilo

Directory of Open Access Journals (Sweden)

Jaime de la Zerda L.

2009-05-01

Full Text Available Se estudiaron los efectos de solvente en la banda del 4-nitrobifenilo en los alcoholes metanol, etanol, I propanol, 2 propanol, 1-butanol, 2-metilpropanol, que fueron purificados cuidadosamente, determinándose luego el grado de pureza que resultó satisfactorio en casi todos los casos. Por ser el agua la impureza persistente en todos ellos, fue necesario estudiar su efecto con cierto detalle.

Processing and benchmarking of evaluated nuclear data file/b-viii.0β4 cross-section library by analysis of a series of critical experimental benchmark using the monte carlo code MCNP(X and NJOY2016

Directory of Open Access Journals (Sweden)

Kabach Ouadie

2017-12-01

Full Text Available To validate the new Evaluated Nuclear Data File (ENDF/B-VIII.0β4 library, 31 different critical cores were selected and used for a benchmark test of the important parameter keff. The four utilized libraries are processed using Nuclear Data Processing Code (NJOY2016. The results obtained with the ENDF/B-VIII.0β4 library were compared against those calculated with ENDF/B-VI.8, ENDF/B-VII.0, and ENDF/B-VII.1 libraries using the Monte Carlo N-Particle (MCNP(X code. All the MCNP(X calculations of keff values with these four libraries were compared with the experimentally measured results, which are available in the International Critically Safety Benchmark Evaluation Project. The obtained results are discussed and analyzed in this paper.

4+D TechnologyTM for nuclear systems soft solutions

International Nuclear Information System (INIS)

Suh, Kune Y.

2010-10-01

The signature in the proposal lies with the NSSS (Nuclear Systems Soft Solutions). NSSS proposed in the 3-dimensional space and time plus cost coordinates, i.e. 4 + dimensional technology, is the backbone of digital engineering in the nuclear system design and management. The NSSS is empowered by Janus (Junctional Analysis Neo dynamic Unit Soft Power), NOTUS (Neo systemic Optimization Technical Unit Soft Power), Venus (Virtual Engineering Neo cybernetic Unit Soft Power), EURUS (Engineering Utilities Research Unit Soft Power) and INUUS (Informative Neo graphic Utilities Unit Soft Power). Janus extracts the geometric data directly from the computer-aided design CAD files to import to multidimensional computational fluid and structural dynamics codes. Janus uses the joint-CAD analysis methods to eliminate the necessity of any pre- and post- processors. Starting from the 3-dimensional CAD, NOTUS contributes to reducing the construction cost of the nuclear power plants by optimizing the component manufacturing procedure and the plant construction process. Planning and scheduling construction projects can thus benefit greatly by integrating traditional management techniques with digital process simulation visualization. The 3-dimensional visualization of construction processes and resulting products intrinsically afford most of the advantages realized by the 4 + D technology. Problems with equipment positioning and manpower congestion in certain areas can readily be visualized prior to the actual operation, thus preventing accidents and safety problems such as collision between two machines and losses in productivity. Venus applied the virtual reality technology in nuclear industry. Virtual reality provides an interactive real time motion with sound and tactile and other forms of feedback. The management and workers can thus comprehend the work process crystal clear by visualizing precisely how activities relate to one another, whereby reducing conflicting

Calcium signals and caspase-12 participated in paraoxon-induced apoptosis in EL4 cells.

Science.gov (United States)

Li, Lan; Cao, Zhiheng; Jia, Pengfei; Wang, Ziren

2010-04-01

In order to investigate whether calcium signals participate in paraoxon (POX)-induced apoptosis in EL4 cells, real-time laser scanning confocal microscopy (LSCM) was used to detect Ca(2+) changes during the POX application. Apoptotic rates of EL4 cells and caspase-12 expression were also evaluated. POX (1-10nM) increased intracellular calcium concentration ([Ca(2+)]i) in EL4 cells in a dose-dependent manner at early stage (0-2h) of POX application, and apoptotic rates of EL4 cells after treatment with POX for 16h were also increased in a dose-dependent manner. Pre-treatment with EGTA, heparin or procaine attenuated POX-induced [Ca(2+)]i elevation and apoptosis. Additionally, POX up-regulated caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibited POX-induced increase of caspase-12 expression. Our results suggested that POX induced [Ca(2+)]i elevation in EL4 cells at the early stage of POX-induced apoptosis, which might involve Ca(2+) efflux from the endoplasmic reticulum (ER) and Ca(2+) influx from extracellular medium. Calcium signals and caspase-12 were important upstream messengers in POX-induced apoptosis in EL4 cells. The ER-associated pathway possibly operated in this apoptosis. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Nuclear engineering experiments at experimental facilities of JNC in graduate course of Tokyo Institute of Technology

International Nuclear Information System (INIS)

Hayashizaki, Noriyosu; Takahashi, Minoru; Aoyama, Takafumi; Onose, Shoji

2005-01-01

Nuclear engineering experiments using outside facilities of the campus have been offered for graduate students in the nuclear engineering course in Tokyo Institute of Technology (Tokyo Tech.). The experiments are managed with the collaboration of Japan Nuclear Cycle Development Institute (JNC), Japan Atomic Energy Research Institute (JAERI) and Research Reactor Institute, Kyoto University (KUR). This report presents the new curriculum of the nuclear engineering experiments at JNC since 2002. The change is due to the shutdown of Deuterium Criticality Assembly Facility (DCA) that was used as an experimental facility until 2001. Reactor physics experiment using the training simulator of the experimental fast reactor JOYO is continued from the previous curriculum with the addition of the criticality approach experiment and control rods calibration. A new experimental subject is an irradiated material experiment at the Material Monitoring Facility (MMF). As a result, both are acceptable as the student experiments on the fast reactor. (author)

El método científico experimental en las clases de laboratorio de física / The experimental scientific method in Physics laboratory lessons

Directory of Open Access Journals (Sweden)

Landa, L. C.

2016-12-01

Full Text Available En el presente estudio los autores abordan la aplicación del método científico experimental en el proceso de enseñanza de la Física como parte del modelo de aprendizaje como investigación en la carrera de Matemática-Física. El análisis de diferentes resultados investigativos publicados en la última década posibilitó identificar avances significativos en este campo, sobre todo en cuanto a la operacionalización del método y la utilización de simulaciones y experimentos virtuales en la enseñanza de la Física, sin embargo, aún persisten insuficiencias en el proceder de los docentes que limitan la apropiación del método por parte de los estudiantes. En particular, se ofrece a los docentes una alternativa metodológica para la introducción del método científico experimental, en las prácticas de laboratorio de Física, que contribuye al tránsito de los estudiantes por los procedimientos del citado método. Finalmente se expone un ejemplo concreto del modo en que se aplicó la alternativa metodológica en una clase de laboratorio de Física. This article deals with the application of the experimental scientific method in the teaching and learning process in Mathematics-Physics career as a part of learning by researching model. The study of references and the analysis of former research findings allow identifying significant achievements in the last ten years, mainly about the application of the method and also the use of virtual experiments and simulation in teaching Physics. However, there are several shortcomings of procedural nature that hinder the students’ appropriation of the method. The main finding is a proposal of a teaching alternative to achieve the learning of the experimental scientific method and its procedures by the students. Finally, that teaching alternative is illustrated in a particular Physics laboratory lesson

The inhibition of apoptosis in EL4 lymphoma cells overexpressing growth hormone.

Science.gov (United States)

Arnold, Robyn E; Weigent, Douglas A

2004-01-01

The antiapoptotic action of exogenous growth hormone (GH) has been reported for several lymphoid cell lines; however, the potential role of endogenous GH in apoptosis has not been thoroughly investigated. This study was designed to investigate the effects of endogenous GH on apoptosis induced by methyl methanesulfonate (MMS) in a T cell lymphoma overexpressing GH (GHo). The results of these experiments have shown that in EL4 lymphoma cells, overexpression of GH sustained viability after exposure to MMS compared to control cells. The extent of DNA fragmentation measured by ladder formation on agarose gels was reduced in GHo cells following treatment with MMS, when compared to control cells. Adding exogenous GH to control cells and treatment of GHo cells with antibodies to GH had no effect on MMS-induced DNA ladder formation. In further studies, DNA microarray analysis suggested a marked decrease in the constitutive expression of bax, BAD, and caspases 3, 8, and 9 in GHo cells compared to controls. In addition, after treatment with MMS, the activities of caspases 2, 3, 6, 8, and 9 were all lower than control in GHo cells. Western blot analysis detected an increase in Bcl-2 while the levels of nuclear factor kappa B (NFkappaB) remained unchanged in GHo cells. Treatment of EL4 cells with antisense deoxyoligonucleotides to GH and specific inhibitors of NFkappaB (SN-50) increased DNA fragmentation. GHo cells show increased levels of phosphorylated Akt and GSK-3, suggesting inactivation of this proapoptotic protein. The results, taken together with our previous data which showed increased nitric oxide formation in GHo cells, suggest a possible mechanism for the antiapoptotic effects of endogenous GH through the production of nitric oxide and support the idea that endogenous GH may play an important role in the survival of lymphocytes exposed to stressful stimuli. Copyright 2004 S. Karger AG, Basel

Experimental nuclear and radiochemistry. Progress report, 1981

International Nuclear Information System (INIS)

Karol, P.J.

1981-09-01

Research progress is reported on the following topics: (1) the importance of classical nucleon-nucleon spatial correlations on nuclear interactions; (2) mathematical development of properly behaved skewed Gaussian function; (3) cluster interactions and true pion absorption; and (4) anomalous relativistic heavy-ion projectile fragments

Shielding analysis method applied to nuclear ship 'MUTSU' and its evaluation based on experimental analyses

International Nuclear Information System (INIS)

Yamaji, Akio; Miyakoshi, Jun-ichi; Iwao, Yoshiaki; Tsubosaka, Akira; Saito, Tetsuo; Fujii, Takayoshi; Okumura, Yoshihiro; Suzuoki, Zenro; Kawakita, Takashi.

1984-01-01

Procedures of shielding analysis are described which were used for the shielding modification design of the Nuclear Ship ''MUTSU''. The calculations of the radiation distribution on board were made using Sn codes ANISN and TWOTRAN, a point kernel code QAD and a Monte Carlo code MORSE. The accuracies of these calculations were investigated through the analysis of various shielding experiments: the shield tank experiment of the Nuclear Ship ''Otto Hahn'', the shielding mock-up experiment for ''MUTSU'' performed in JRR-4, the shielding benchmark experiment using the 16 N radiation facility of AERE Harwell and the shielding effect experiment of the ship structure performed in the training ship ''Shintoku-Maru''. The values calculated by the ANISN agree with the data measured at ''Otto Hahn'' within a factor of 2 for fast neutrons and within a factor of 3 for epithermal and thermal neutrons. The γ-ray dose rates calculated by the QAD agree with the measured values within 30% for the analysis of the experiment in JRR-4. The design values for ''MUTSU'' were determined in consequence of these experimental analyses. (author)

[Antitumor effects of matrix protein of vesicular stomatic virus on EL4 lymphoma mice].

Science.gov (United States)

Lin, Shi-jia; Yu, Qin-mei; Meng, Wen-tong; Wen, Yan-jun; Chen, Li-juan; Niu, Ting

2011-03-01

To explore antitumor effects of plasmid pcDNA3. 1-MP encoding matrix protein of vesicular stomatitis virus (VSV) complexed with cationic liposome (DOTAP:CHOL) in mice with EL4 lymphoma. C57BL/6 mouse model with EL4 lymphoma was established. Sixty mice bearing EL4 lymphoma were divided randomly into five groups including Lip-MP, Lip-pVAX, Lip, ADM and NS groups, which were intravenously injected with liposome-pcDNA 3. 1-MP complex, liposome-pVAX complex, empty liposome, Adriamycin and normal saline respectively every three days. Tumor volumes and survival time were monitored. Microvessel density and tumor proliferative index in tumor tissues were determined by CD31, Ki-67 immunohistochemistry staining, meanwhile the tumor apoptosis index was measured by TUNEL method. From 6 days after treatments on, the tumor volume in Lip-MP group was much smaller than that in Lip-pVAX, Lip and NS group (P EL4 tumor cells in vivo (P EL4 lymphoma, which may be related to the induction of tumor cell apoptosis, inhibition of tumor angiogenesis, and suppression of tumor cell proliferation.

f-electron-nuclear hyperfine-coupled multiplets in the unconventional charge order phase of filled skutterudite PrRu4P12

International Nuclear Information System (INIS)

Aoki, Yuji; Namiki, Takahiro; Saha, Shanta R.; Sato, Hideyuki; Tayama, Takashi; Sakakibara, Toshiro; Shiina, Ryousuke; Shiba, Hiroyuki; Sugawara, Hitoshi

2011-01-01

The filled skutterudite PrRu 4 P 12 is known to undergo an unconventional charge order phase transition at 63 K, below which two sublattices with distinct f-electron crystalline-electric-field ground states are formed. In this paper, we study experimentally and theoretically the properties of the charge order phase at very low temperature, particularly focusing on the nature of the degenerate triplet ground state on one of the sublattices. First, we present experimental results of specific heat and magnetization measured with high quality single crystals. In spite of the absence of any symmetry breaking, the specific heat shows a peak structure at T p =0.30 K in zero field; it shifts to higher temperatures as the magnetic field is applied. In addition, the magnetization curve has a remarkable rounding below 1 T. Then, we study the origin of these experimental findings by considering the hyperfine interaction between 4f electron and nuclear spin. We demonstrate that the puzzling behaviors at low temperatures can be well accounted for by the formation of 4f-electron-nuclear hyperfine-coupled multiplets, the first thermodynamical observation of its kind. (author)

Contribution to the improvement of the evaluation methods of nuclear heating in reactors by using the Monte Carlo code TRIPOLI-4

International Nuclear Information System (INIS)

Peron, Arthur

2014-01-01

Technological irradiation programs carried out in experimental reactors are crucial for the support of the current nuclear fleet in terms of study and anticipation of the behavior under irradiation of fuels and structural materials. These programs make it possible to improve the safety of the current reactors and also to study materials for the new concepts of reactors. Irradiation conditions of materials in experimental reactors must be representative of those of nuclear power plants (NPPs). One of the main advantages of material testing reactors (MTRs) is to be able to carry out instrumented irradiations by adjusting experimental parameters, in particular the neutron flux and the temperature. The control of the parameter temperature of a device irradiated in an experimental reactor requires the knowledge of the nuclear heating (source term) due to the deposition of energy of the photons and the neutrons interacting in the device. A relevant evaluation of this heating is a key data for the thermal studies of design and safety of devices. The objective of this thesis is to improve the methods of the evaluation of nuclear heating in reactors. This work consists of the development of an innovating and complete coupled neutron-photon calculation scheme (allowing to obtain the contribution of neutrons, prompt gamma and decay gamma), mainly based on the 3D, continuous energy TRIPOLI-4 Monte Carlo transport code. An experimental validation of the calculation scheme has been performed, based on calorimetry measurements carried out in the OSIRIS reactor at CEA Saclay. Sensitivity studies have been undertaken to establish the impact of various parameters on nuclear heating calculations (in particular nuclear data) and to fix the final calculation scheme to be closer to the technological irradiation aspects. The thesis work leads to an operational and predictive tool for the nuclear heating estimation, meeting the experimentation needs of research reactors and can be

Program PLOTC4 (Version 86-1). Plot evaluated data from the ENDF/B format and/or experimental data which is in a computation format

International Nuclear Information System (INIS)

Cullen, D.E.

1986-09-01

Experimental and evaluated nuclear reaction data are world-wide compiled in EXFOR format and ENDF format, respectively. The computer program PLOTC4 described in the present document plots data from both formats; EXFOR data must be converted first to a ''computation format''. The program is available costfree from the IAEA Nuclear Data Section, upon request. (author)

The Text of a Regional Co-operative Agreement for Research, Development and Training related to Nuclear Science and Technology. Latest Status. Declarations/Reservations; Texto de un Acuerdo de Cooperacion Regional Para la Investigacion, el Desarrollo y la Capacitacion en Materia de Ciencias y Tecnologia Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1972-08-18

The text of a Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology between the Agency and Member States is reproduced herein for the information of all Members. Section 9 thereof specifies the Members that may become party to it [Spanish] Para conocimiento de todos los Estados Miembros en el presente documento se transcribe el texto de un Acuerdo de Cooperacion Regional para la investigacion, el desarrollo y la capacitacion en materia de ciencias y tecnologia nucleares entre el Organismo y los Estados Miembros. En la Seccion 9 se especifican los Estados Miembros que pueden ser partes en el Acuerdo.

Experimental model of the device for detection of nuclear cycle materials by photoneutron technology

International Nuclear Information System (INIS)

Bakalyarov, A.M.; Karetnikov, M.D.; Kozlov, K.N.; Lebedev, V.I.; Meleshko, E.A.; Obinyakov, B.A.; Ostashev, I.E.; Tupikin, N.A.; Yakovlev, G.V.

2007-01-01

The inherent complexity of sea container control makes them potentially dangerous for smuggling nuclear materials. The experts believe that only active technologies based on recording the products of induced radiation from sensitive materials might solve the problem. The paper reports on the experimental model of the device on the basis of the electron LINAC U-28 for detection of nuclear materials by photonuclear technology. The preliminary numerical optimization of output units (converter, filter, collimator) for shaping the bremsstrahlung was carried out. The setup of experimental device and initial results of recording the prompt and delayed fission products are discussed

Los niveles de anticuerpos anti factor plaquetario 4-heparina y el índice 4T para trombocitopenia inducida por heparina

Directory of Open Access Journals (Sweden)

Marta E. Martinuzzo

2012-02-01

Full Text Available La trombocitopenia inducida por heparina (HIT es un efecto adverso del tratamiento con heparina, mediada por anticuerpos anti complejo factor plaquetario 4 (PF4-heparina (HPIA. La HIT es frecuentemente moderada pero pueden desarrollarse complicaciones trombóticas. El diagnóstico precoz es importante. La detección de HPIA por ELISA tiene alta sensibilidad pero baja especificidad (títulos bajos sin significación clínica. El índice de las 4T (índice 4T puede detectar pacientes con alto riesgo de HIT. El propósito del estudio fue correlacionar los niveles de HPIA y el índice 4T de un grupo de pacientes derivados a nuestro centro. Evaluamos 84 pacientes, 34 de ellos desarrollaron trombosis. Cada médico completó un cuestionario clínico que fue remitido con la muestra a nuestro centro. Los cuestionarios fueron analizados por un investigador externo y el índice 4T se calculó previamente al ensayo. Los HPIA se determinaron por un ELISA (Asserachrom HPIA que detecta los 3 isotipos, IgG, IgM e IgA, único reactivo disponible en Argentina. Los resultados se expresaron como porcentaje de absorbancia (%ABS. La correlación del índice 4T con los HPIA fue 0.472 (rho spearman, p < 0.001. Los pacientes con índice 4T ≥ 6 presentaban %ABS mayores que los ≤ 5 (67 vs. 39, p < 0.001. Aquéllos con trombosis presentaron títulos mayores que los que no la desarrollaron (%ABS 59 vs. 39, p = 0.017. En conclusión: Los títulos altos de HPIA medidos por ELISA, que detecta los 3 isotipos, correlacionaron claramente con el índice 4T ≥ 6 y fueron más frecuentes en los pacientes con trombosis, coincidiendo con lo ya descripto para ensayos de ELISA específicos para isotipo IgG.

Experimental study and nuclear model calculations of {sup 3}He-induced nuclear reactions on zinc

Energy Technology Data Exchange (ETDEWEB)

Al-Abyad, M.; Mohamed, Gehan Y. [Nuclear Research Centre, Atomic Energy Authority, Physics Department (Cyclotron Facility), Cairo (Egypt); Ditroi, F.; Takacs, S.; Tarkanyi, F. [Hungarian Academy of Sciences (ATOMKI), Institute for Nuclear Research, Debrecen (Hungary)

2017-05-15

Excitation functions of {sup 3}He-induced nuclear reactions on natural zinc were measured using the standard stacked-foil technique and high-resolution gamma-ray spectrometry. From their threshold energies up to 27 MeV, the cross-sections for {sup nat}Zn ({sup 3}He,xn) {sup 69}Ge, {sup nat}Zn({sup 3}He,xnp) {sup 66,67,68}Ga, and {sup nat}Zn({sup 3}He,x){sup 62,65}Zn reactions were measured. The nuclear model codes TALYS-1.6, EMPIRE-3.2 and ALICE-IPPE were used to describe the formation of these products. The present data were compared with the theoretical results and with the available experimental data. Integral yields for some important radioisotopes were determined. (orig.)

Experimental nuclear physics: Progress report, September 1986-July 1987

International Nuclear Information System (INIS)

Hamilton, J.H.

1987-08-01

The research activities of the experimental nuclear structure group at Vanderbilt University carried out under Contract AS05-76ER05034 with the Department of Energy for the period September 1986 to July 1987 are reported here. Research continues in the areas of (1) in-beam γ-ray spectroscopy including cooperations with scientists at Oak Ridge, Univ. of Rochester, Univ. of Koeln, Louisiana State Univ., Univ. of Florida, Idaho Falls, and Univ. of Notre Dame; (2) studies of nuclei far from stability at UNISOR and at the recoil mass spectrometer at the University of Rochester; (3) nucleon transfer reaction and fusion-fission studies with scientists at ORNL, Argonne National Laboratory, Univ. of Michigan, and University of Kansas; (4) theoretical studies with scientists at Univ. Frankfurt, Univ. Tuebingen, Univ. Lund, Brookhaven, Lawrence Berkeley, and ORNL; (5) other studies. In general, abstracts of papers published or submitted for publication in this period make up this report along with brief reports of work in process and complete copies of a few conference papers

Techno-political and sectorial culture in a semi-peripheral context: nuclear development in Argentina (1945-1994); Cultura tecnológico-política sectorial en contexto semiperiférico: el desarrollo nuclear en la Argentina (1945-1994)

Energy Technology Data Exchange (ETDEWEB)

Hurtado, Diego [Centro de Estudios de Historia de la Ciencia José Babini, Universidad Nacional de San Martín, Buenos Aires (Argentina)

2013-07-01

Considering Argentina as a semi-peripheral country, the present article analyzes the establishment of a nuclear culture and a nuclear technopolitical regime -aimed at seeking technological autonomy and regional leadership as well as the promotion of a national nuclear industry- that have the Argentine Atomic Energy Commission as institutional epicenter and kept some of their main traits and orientation until the beginnings of the 1990s. The article focuses mainly on three aspects: the development of nuclear research reactors; the processes of decision-making about the purchase and construction of the country's two power nuclear plants; and the way the various political regimes that Argentina went through -democratic, semi-democratic and dictatorial periods- and regimes of accumulation -sustitutive industrialization and, since the last military dictatorship, economic deregulation- impacted and left their mark on the evolution of the nuclear technopolitical regime. Within this last point, international pressures are assumed as a crucial component. (authors) [Spanish] A partir de la caracterización de la Argentina como país semiperiférico, el presente trabajo analiza la conformación de una 'cultura nuclear' y de un 'régimen tecnopolítico nuclear' -definido por la búsqueda de la autonomía tecnológica y el liderazgo regional y por la promoción de una industria nuclear nacional- que tuvieron como epicentro institucional a la Comisión Nacional de Energía Atómica y mantuvieron su vigencia hasta comienzos de los años noventa. El artículo se enfoca en tres ejes: el desarrollo de reactores de investigación; los procesos de toma de decisiones alrededor para la compra y construcción de las centrales de potencia; y la forma en que los distintos regímenes políticos por los que atravesó la Argentina -períodos de democracia, 'semi- democracia' y dictadura- y regímenes de acumulación -industrialización sustitutiva y, desde la última dictadura, desregulaci

Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone.

Science.gov (United States)

Weigent, Douglas A

2009-01-01

In previous studies, we have shown that overexpression of growth hormone (GH) in cells of the immune system upregulates proteins involved in cell growth and protects from apoptosis. Here, we report that overexpression of GH in EL4 T lymphoma cells (GHo) also significantly increased levels of the inhibitor of differentiation-2 (Id2). The increase in Id2 was suggested in both Id2 promoter luciferase assays and by Western analysis for Id2 protein. To identify the regulatory elements that mediate transcriptional activation by GH in the Id2 promoter, promoter deletion analysis was performed. Deletion analysis revealed that transactivation involved a 301-132bp region upstream to the Id2 transcriptional start site. The pattern in the human GHo Jurkat T lymphoma cell line paralleled that found in the mouse GHo EL4 T lymphoma cell line. Significantly less Id2 was detected in the nucleus of GHo EL4 T lymphoma cells compared to vector alone controls. Although serum increased the levels of Id2 in control vector alone cells, no difference was found in the total levels of Id2 in GHo EL4 T lymphoma cells treated with or without serum. The increase in Id2 expression in GHo EL4 T lymphoma cells measured by Id2 promoter luciferase expression and Western blot analysis was blocked by the overexpression of a dominant-negative mutant of STAT5. The results suggest that in EL4 T lymphoma cells overexpressing GH, there is an upregulation of Id2 protein that appears to involve STAT protein activity.

Global nuclear-structure calculations

International Nuclear Information System (INIS)

Moeller, P.; Nix, J.R.

1990-01-01

The revival of interest in nuclear ground-state octupole deformations that occurred in the 1980's was stimulated by observations in 1980 of particularly large deviations between calculated and experimental masses in the Ra region, in a global calculation of nuclear ground-state masses. By minimizing the total potential energy with respect to octupole shape degrees of freedom in addition to ε 2 and ε 4 used originally, a vastly improved agreement between calculated and experimental masses was obtained. To study the global behavior and interrelationships between other nuclear properties, we calculate nuclear ground-state masses, spins, pairing gaps and Β-decay and half-lives and compare the results to experimental qualities. The calculations are based on the macroscopic-microscopic approach, with the microscopic contributions calculated in a folded-Yukawa single-particle potential

Studies for the layout and technical conception of a two-circuit HTR power plant of 600 MWsub(el) under public utilizer aspects

International Nuclear Information System (INIS)

Schuetten, R.

1981-01-01

In this study concerning conceptions for a nuclear power plant of 600 MWsub(el) with high-temperature reactor a conception for a HTR-nuclear power plant of 600 MWsub(el) to be built in the Federal Republic of Germany in future is developed on the basis of operating experience with the 15-MW-AVR-experimental nuclear power plant, the construction of the THTR-300 nuclear power plant and the gas-cooled reactors of English, French and American origin. This report gives a survey of the most important findings and the requirements on behalf of the public utilities for a nuclear power plant with high-temperature reactor with the dimensions of 600 MWsub(el). The examination of the utilities basic requirements for a power plant and the experience made during the licensing procedure led to this technical and safety conception for a HTR nuclear power plant with spherical fuel elements. In addition, the questions of the possibility of recurrent tests and of repairing safety components and also the future shut-down of the power plant, which are important for the public utilities, are examined. (orig./GL) [de

Research at the Section of Experimental Nuclear Physics of ATOMKI

International Nuclear Information System (INIS)

Krasznahorkay, A.; Fenyes, T.; Dombradi, Zs.; Nyako, B.M.; Timar, J.; Algora, A.; Csatlos, M.; Csige, L.; Gacsi, Z.; Gulyas, J.

2011-01-01

Introduction. Nuclear physics research was started in Debrecen by Alexander Szalay (1909-1987) back in the 30's. He had been a postdoc of the Nobel-laureate biologist Albert Szent-Gyorgyi in Szeged and of Lord Rutherford in Cambridge. ATOMKI was founded in Debrecen later, in 1954. The Institute was meant to pursue scientific research in certain areas of experimental nuclear physics and to develop research instruments In the early years the country was pretty isolated, but the institute's state of isolation was gradually easing up from the mid-sixties. During the period 1962-1975 the research work was performed in collaboration with Joint Institute for Nuclear Research (Dubna), where up-to-date high-energy accelerators were available for the production of desired isotopes. After finishing the construction of a home-made 5 MV Van de Graaff accelerator (1972) and later on the installation of a K=20 light ion cyclotron (1985) the Institute has become the main centre of accelerator-based nuclear physics in Hungary. In the period 1975-1995 our group performed extensive nuclear structure studies in Debrecen by using γ and conversion electron spectroscopy. At the same time fruitful collaborations were initiated with Jyvaskyla (Finland), with University of Kentucky and University of Zagreb. In 1993 the former Nuclear Reaction Group (NRG) merged with our group. Parallel with this structural change, the main topics of our γ-spectroscopic work has also changed, which resulted that the location of our experiments were shifted from the home institute to foreign large-scale facilities. New topics were brought partly by the emerging NRG, partly by group members returning from postdoctoral fellowships. They also brought important non γ-spectroscopic topics, which enriched our research palette. These new topics have by now become joint endeavours involving more and more group members. The Nuclear Physics European Coordination Committee (NuPECC) has recently stated that the aim of

Computational Fluid Dynamics (CFD) in Nuclear Reactor Safety (NRS) - Proceedings of the workshop on Experiments and CFD Code Application to Nuclear Reactor Safety (XCFD4NRS)

International Nuclear Information System (INIS)

2008-01-01

Computational Fluid Dynamics (CFD) is to an increasing extent being adopted in nuclear reactor safety analyses as a tool that enables specific safety relevant phenomena occurring in the reactor coolant system to be better described. The Committee on the Safety of Nuclear Installations (CSNI), which is responsible for the activities of the OECD Nuclear Energy Agency that support advancing the technical base of the safety of nuclear installations, has in recent years conducted an important activity in the CFD area. This activity has been carried out within the scope of the CSNI working group on the analysis and management of accidents (GAMA), and has mainly focused on the formulation of user guidelines and on the assessment and verification of CFD codes. It is in this GAMA framework that a first workshop CFD4NRS was organized and held in Garching, Germany in 2006. Following the CFD4NRS workshop, this XCFD4NRS Workshop was intended to extend the forum created for numerical analysts and experimentalists to exchange information in the field of Nuclear Reactor Safety (NRS) related activities relevant to Computational Fluid Dynamics (CFD) validation, but this time with more emphasis placed on new experimental techniques and two-phase CFD applications. The purpose of the workshop was to provide a forum for numerical analysts and experimentalists to exchange information in the field of NRS-related activities relevant to CFD validation, with the objective of providing input to GAMA CFD experts to create a practical, state-of-the-art, web-based assessment matrix on the use of CFD for NRS applications. The scope of XCFD4NRS includes: - Single-phase and two-phase CFD simulations with an emphasis on validation in areas such as: boiling flows, free-surface flows, direct contact condensation and turbulent mixing. These applications should relate to NRS-relevant issues such as: pressurized thermal shocks, critical heat flux, pool heat exchangers, boron dilution, hydrogen

The experimental nuclear reaction data (EXFOR): Extended computer database and Web retrieval system

Science.gov (United States)

Zerkin, V. V.; Pritychenko, B.

2018-04-01

The EXchange FORmat (EXFOR) experimental nuclear reaction database and the associated Web interface provide access to the wealth of low- and intermediate-energy nuclear reaction physics data. This resource is based on numerical data sets and bibliographical information of ∼22,000 experiments since the beginning of nuclear science. The principles of the computer database organization, its extended contents and Web applications development are described. New capabilities for the data sets uploads, renormalization, covariance matrix, and inverse reaction calculations are presented. The EXFOR database, updated monthly, provides an essential support for nuclear data evaluation, application development, and research activities. It is publicly available at the websites of the International Atomic Energy Agency Nuclear Data Section, http://www-nds.iaea.org/exfor, the U.S. National Nuclear Data Center, http://www.nndc.bnl.gov/exfor, and the mirror sites in China, India and Russian Federation.

Investigation of analytical and experimental behavior of nuclear facility ventilation systems

International Nuclear Information System (INIS)

Smith, P.R.; Ricketts, C.I.; Andrae, R.W.; Bolstad, J.W.; Horak, H.L.; Martin, R.A.; Tang, P.K.; Gregory, W.S.

1979-01-01

The behavior of nuclear facility ventilation systems subjected to both natural and man-caused accidents is being investigated. The purpose of the paper is to present a program overview and highlight recent results of the investigations. The program includes both analytical and experimental investigations. Computer codes for predicting accident-induced gas dynamics and test facilities to obtain supportive experimental data to define structural integrity and confinement effectiveness of ventilation system components are described. A unique test facility and recently obtained structural limits for high efficiency particulate air filters are reported

Programa de lectura inicial en el desarrollo de la comprensión lectora de los estudiantes de 4 años en la Institución Educativa Inicial N°334-UGEL N°04- 2014

OpenAIRE

Alarcon Navarro, Juana Rosario

2015-01-01

El presente trabajo de investigación tuvo por objetivo demostrar cómo influye el Programa de lectura inicial en el desarrollo de la comprensión lectora de los estudiantes de 4 años de la I.E.I N° 334 UGEL N° 04-2014. El tipo de investigación es de tipo aplicada. La metodología corresponde a un enfoque cuantitativo, con un nivel explicativo, el diseño fue de tipo cuasiexperimental con un grupo de control y un experimental, con pre prueba para establecer el grado de equivalencia ...

Nuclear Technology Series. Course 4: Heat Transfer and Fluid Flow.

Science.gov (United States)

Center for Occupational Research and Development, Inc., Waco, TX.

This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

The Physical Protection of Nuclear Material and Nuclear Facilities; Proteccion Fisica De Los Materiales Y Las Instalaciones Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-06-15

Physical protection against the theft or unauthorized diversion of nuclear materials and against the sabotage of nuclear facilities by individuals or groups has long been a matter of national and international concern. Although responsibility for establishing and operating a comprehensive physical protection system for nuclear materials and facilities within a State rests entirely with the Government of that State, it is not a matter of indifference to other States whether and to what extent that responsibility is fulfilled. Physical protection has therefore become a matter of international concern and co-operation. The need for international co-operation becomes evident in situations where the effectiveness of physical protection in one State depends on the taking by other States also of adequate measures to deter or defeat hostile actions against nuclear facilities and nuclear materials, particularly when such materials are transported across national frontiers [Spanish] La proteccion fisica contra el robo o la desviacion no autorizada de materiales nucleares y contra el sabotaje de las instalaciones nucleares por parte de individuos o grupos es motivo de preocupacion nacional e internacional desde hace mucho tiempo. Aunque la obligacion de crear y hacer funcionar un sistema completo de proteccion fisica de las instalaciones y materiales nucleares en el territorio de un Estado determinado incumbe exclusivamente al Gobierno de dicho Estado, el que esa obligacion se cumpla o no, y si se cumple, en que medida o hasta que punto, son cosas que no dejan indiferentes a los demas Estados. Por ello, la proteccion fisica se ha convertido en motivo de interes y cooperacion internacional. La necesidad de la cooperacion internacional se hace evidente en los casos en que la eficacia de la proteccion fisica en el territorio de un Estado depende de que otros Estados tomen tambien medidas apropiadas para evitar o hacer fracasar los actos hostiles dirigidos contra instalaciones y

Experimental studies of keV energy neutron-induced reactions relevant to astrophysics and nuclear physics

Energy Technology Data Exchange (ETDEWEB)

Shima, T.; Kii, T.; Kikuchi, T.; Okazaki, F.; Kobayashi, T.; Baba, T.; Nagai, Y. [Tokyo Inst. of Tech. (Japan). Faculty of Science; Igashira, M.

1997-03-01

Nuclear reactions induced by keV energy neutrons provide a plenty of informations for studies of both astrophysics and nuclear physics. In this paper we will show our experimental studies of neutron- induced reactions of light nuclei in the keV energy region by means of a pulsed keV neutron beam and high-sensitivity detectors. Also we will discuss astrophysical and nuclear-physical consequences by using the obtained results. (author)

Selective up-regulation of protein kinase C eta in phorbol ester-sensitive versus -resistant EL4 mouse thymoma cells.

Science.gov (United States)

Resnick, M S; Luo, X; Vinton, E G; Sando, J J

1997-06-01

Stimulation of sensitive EL4 mouse thymoma cells (s-EL4) with phorbol esters results in production of interleukin 2 (IL-2), adherence to a plastic substrate, and growth inhibition, whereas a phorbol ester-resistant variant (r-EL4) fails to respond. Previous studies revealed substantially decreased expression of protein kinase C (PKC) epsilon in the r-EL4 versus s-EL4 cells. This work has been extended to examine the more recently described PKC isozymes. Western and Northern analyses revealed a marked decrease in PKC eta and theta in r-EL4 as compared to s-EL4 cells. Treatment of these lines with phorbol ester for 24 h resulted in down-regulation of all PKC isozymes examined except PKC eta, which was up-regulated in the s-EL4 cells at the time of maximal IL-2 production. Two newly isolated EL4 clones, resistant to phorbol ester-induced growth inhibition but still exhibiting the phorbol ester-induced adherence and IL-2 production, both expressed PKC eta and theta. Collectively, these observations suggest a dissociation of growth inhibition from adherence and IL-2 production pathways and a potential role for PKC eta in the latter.

GRANULOCYTE INFILTRATION AND EXPRESSION OF THE PRO-ANGIOGENIC BV8 PROTEIN IN EXPERIMENTAL EL4 AND LEWIS LUNG CARCINOMA TUMORS.

Science.gov (United States)

Jiang, Kan; Kwak, Hyeongil; Tosato, Giovanna

2013-01-18

Although Vascular Endothelial Growth Factor (VEGF)-targeted therapies have shown efficacy in the treatment of certain advanced cancers, benefits to patients have been modest, which is attributed to tumor resistance to VEGF neutralization. Recent efforts to identify new targets to inhibit tumor angiogenesis have identified Bv8 (prokineticin 2), a myeloid cell-derived protein that promotes endothelial cell growth and tumor angiogenesis, but many mechanistic aspects of the pro-tumorigenic function of Bv8 are unclear. Here we demonstrate that CD11b+, Ly6C+, Ly6G+ granulocytes are the predominant cell source of Bv8 expression in bone marrow, spleen and in tumor tissues. Using granulocyte-deficient Growth factor independence-1 (Gfi1)-null mutant mice and normal littermates, we found that EL4 lymphoma tumors grow significantly larger in the granulocyte and Bv8-deficient mutant mice in comparison to the normal mice that display abundant tumor-associated granulocytes and Bv8 expression. Conversely, Lewis lung carcinoma (LLC-1) tumors grew to a significantly greater size in the normal mice in comparison to the Gfi1-null mice, but normal granulocyte tumor infiltration was modest. Quantitative analysis of tissue vascularization showed that EL4 and LLC-1 tumors from normal and Gfi1-mutant mice are similarly vascularized. These results confirm the critical contribution of the tumor microenvironment in determining the rate of tumor progression independently of tumor angiogenesis, and reveal some of the complexities of granulocyte and Bv8 functions in modulating tumor growth.

Diseño y desarrollo de una instalación experimental mediante el uso de herramientas de impresión 3D para el estudio y simulación de flujos granulares

OpenAIRE

Martínez Pedrero, Borja

2017-01-01

El presento proyecto surge de la motivación para realizar una práctica teórico experimental, llevada a cabo por alumnos de la Escuela Técnica Superior de Ingenieros Industriales de Madrid (ETSIIM), en la que se estudie el comportamiento de sólidos granulares en una instalación experimental de almacenamiento y descarga elaborada mediante herramientas de impresión 3D. A este tipo de sólidos se les denomina granulares porque están compuestos por numerosas partículas, cuyas propiedades unitar...

El origen ilícito en el delito de lavado de activos en el Ecuador

OpenAIRE

Aldaz Valdez, Ángel Monfilio

2009-01-01

La presente tesis aborda temas de interés nacional y mundial sobre el lavado de activos, temática que va tomando importancia relevante, pues las bandas criminales, nacionales e internacionales, ante la imperiosa necesidad de tratar de blanquear los dineros productos de sus ilícitos, buscan diversas formas de lavar el dinero producto de sus fechorías. En el capítulo I se abordan aspectos doctrinarios; conceptos nucleares que hacen relación a la terminología utilizada en esta inv...

Utilization of the RELAP4 in the experimental water loop of the IPEN-CNEN/SP

International Nuclear Information System (INIS)

Sabundjian, G.

1991-09-01

For a better security of the nuclear power station and the population, thermal hydraulics codes for accident analysis were developed. Within all codes, the RELAP4, developed by Aerojet Nuclear Company of the Idaho Falls Engineering Laboratory (U.S.A.), has been the more used mostly by the fact of been available to the public. These code presents the most satisfactory results when used for various sort of problems. Basely the paper analyzes and compares the RELAP4/MOD3 and MOD5 versions, through the simulation on the Water Experimental Loop (C.E.A.) of the IPEN, in the steady state and in accidents conditions. Although the C.E.A. had been constructed to simulate PWR and BWR reactors, in these paper the tests were made only for PWR. Through the results analysis found in these paper, we concluded that the model adaptation for the simulations made with the RELAP4 code (version MOD3 and MOD5), were satisfactory. The accidents simulations indicates that the C.E.A. can support accident situation with the emergency system acting. Comparing the two versions, the MOD5 presented the better results compared with the real estimations. (author)

EXFOR – a global experimental nuclear reaction data repository: Status and new developments

Directory of Open Access Journals (Sweden)

Semkova Valentina

2017-01-01

Full Text Available Members of the International Network of Nuclear Reaction Data Centres (NRDC have collaborated since the 1960s on the worldwide collection, compilation and dissemination of experimental nuclear reaction data. New publications are systematically complied, and all agreed data assembled and incorporated within the EXFOR database. Recent upgrades to achieve greater completeness of the contents are described, along with reviews and adjustments of the compilation rules for specific types of data.

IAEA Director General welcomes landmark convention to combat nuclear terrorism

International Nuclear Information System (INIS)

2005-01-01

Full text: IAEA Director General Mohamed ElBaradei welcomed the adoption of an International convention against nuclear terrorism. 'This is a landmark achievement which will bolster global efforts to combat nuclear terrorism,' Dr. ElBaradei said. 'It will be a key part of international efforts to prevent terrorists from gaining access to nuclear weapons'. The United Nations General Assembly adopted the convention, The International Convention for the Suppression of Acts of Nuclear Terrorism, on 13 April 2005. The Convention strengthens the global legal framework to counter terrorist threats. Based on a proposal by the Russian Federation in 1998, the Convention focuses on criminal offences related to nuclear terrorism and covers a broad range of possible targets, including nuclear reactors as well as nuclear material and radioactive substances. Under its provisions, alleged offenders - for example any individual or group that unlawfully and intentionally possesses or uses radioactive material with the intent to cause harm - must be either extradited or prosecuted. States are also encouraged to cooperate with each other in connection with criminal investigations and extradition proceedings. The Convention further requires that any seized nuclear or radiological material be held in accordance with IAEA safeguards, and handled in keeping with the IAEA's health, safety and physical protection standards. Dr. ElBaradei also recalled that the Agency is in the process of amending the Convention on the Physical Protection of Nuclear Material, in order to broaden its scope, and in so doing, strengthen the current legal framework for securing nuclear material against illicit uses. A conference will be held from 4 to 8 July in Vienna to consider and adopt the amendments. The Convention opens for signature in September this year. Dr ElBaradei urged all States to 'sign and ratify the Convention without delay so nuclear terrorism will have no chance'. (IAEA)

MANIA (276-3/4/5). Nuclear analysis

International Nuclear Information System (INIS)

Sciolla, C.M.

1993-11-01

This report contains the results of the nuclear calculations performed for the MANIA-276 experiment, sample holders 3, 4 and 5. The codes MICROFLUX-2, GAM, HFR-TEDDI and ORIGEN-S have been used for this analysis. Nuclear constants, dpa, reactivity effect and activity of the samples and of the structural materials have been calculated. The results are given in the tables and appendices of the present report. (orig.)

Identifying Understudied Nuclear Reactions by Text-mining the EXFOR Experimental Nuclear Reaction Library

Energy Technology Data Exchange (ETDEWEB)

Hirdt, J.A. [Department of Mathematics and Computer Science, St. Joseph' s College, Patchogue, NY 11772 (United States); Brown, D.A., E-mail: dbrown@bnl.gov [National Nuclear Data Center, Brookhaven National Laboratory, Upton, NY 11973-5000 (United States)

2016-01-15

The EXFOR library contains the largest collection of experimental nuclear reaction data available as well as the data's bibliographic information and experimental details. We text-mined the REACTION and MONITOR fields of the ENTRYs in the EXFOR library in order to identify understudied reactions and quantities. Using the results of the text-mining, we created an undirected graph from the EXFOR datasets with each graph node representing a single reaction and quantity and graph links representing the various types of connections between these reactions and quantities. This graph is an abstract representation of the connections in EXFOR, similar to graphs of social networks, authorship networks, etc. We use various graph theoretical tools to identify important yet understudied reactions and quantities in EXFOR. Although we identified a few cross sections relevant for shielding applications and isotope production, mostly we identified charged particle fluence monitor cross sections. As a side effect of this work, we learn that our abstract graph is typical of other real-world graphs.

Identifying Understudied Nuclear Reactions by Text-mining the EXFOR Experimental Nuclear Reaction Library

International Nuclear Information System (INIS)

Hirdt, J.A.; Brown, D.A.

2016-01-01

The EXFOR library contains the largest collection of experimental nuclear reaction data available as well as the data's bibliographic information and experimental details. We text-mined the REACTION and MONITOR fields of the ENTRYs in the EXFOR library in order to identify understudied reactions and quantities. Using the results of the text-mining, we created an undirected graph from the EXFOR datasets with each graph node representing a single reaction and quantity and graph links representing the various types of connections between these reactions and quantities. This graph is an abstract representation of the connections in EXFOR, similar to graphs of social networks, authorship networks, etc. We use various graph theoretical tools to identify important yet understudied reactions and quantities in EXFOR. Although we identified a few cross sections relevant for shielding applications and isotope production, mostly we identified charged particle fluence monitor cross sections. As a side effect of this work, we learn that our abstract graph is typical of other real-world graphs.

Effect of RNAi p21 gene on uncoupling of EL-4 cells induced by X-irradiation

International Nuclear Information System (INIS)

Ju Guizhi; Yan Fengqin; Fu Shibo; Shen Bo; Sun Shilong; Yang Ying; Li Pengwu

2008-01-01

Objective: To investigate the effect of RNAi p21 gene on uncoupling of EL-4 cells induced by X-irradiation. Methods: Construction of RNAi p21 plasmid of pSileneer3.1-H1 neo-p21 was performed. Lipofectamine transfection assay was used to transfer the p21siBNA into EL-4 cells. Fluorescent staining and flow cytometry (FCM) analysis were employed for measurement of protein expression. Fluorescent staining of propidium iodide (PI) and FCM were used for measurement of potyploid cells. Results: In dose-effect experiment it was found that the expression of P21 protein of EL-4 cells increased significantly 24 h after X- irradiation with different doses compared with sham-inadiated control. In time course experiment it was found that the expression of P21 protein of EL-4 cells increased significantly at 8 h to 72 h after 4.0 Gy X-irradiation compared with sham-irradiated control. The results showed that the number of polyploid cells in EL-4 cells was not changed markedly after X-irradiation with doses of 0.5-6.0 Gy. After RNA interference with p21 gene, the expression of P21 protein of EL-4 cells decreased significantly 24 h and 48 h after 4.0 Gy X-irradiation in transfection of plasmid of pSilencer3.1-H1 neo-p21 compared with transfection of plasmid of pSilencer3.1-H1 nco control. And at the same time, the number of polyploid cells in EL-4 cells was increased significantly in transfection of plasmid of pSilencer3.1-H1 neo-p21 compared with transfection of plasmid of pSilencer3.1-H1 nco control. Conclusions: Uncoupling could be induced by X-irradiation in EL-4 cells following BNAi p21 gene, suggesting that P21 protein may play an important role in uncoupling induced by X-rays. (authors)

Nuclear Physics Division, Institute of Experimental Physics, Warsaw University annual report 1995

Energy Technology Data Exchange (ETDEWEB)

Osuch, S [ed.

1997-12-31

In the presented Annual Report the activities of Nuclear Physics Division (NPD) of Warsaw University in 1995 are described. The report consists of three sections: (i) Reaction Mechanism and Nuclear Structure (11 articles); (ii) Instrumentation and Experimental Methods (9 articles); (iii) Other Research (1 article). Additionally the list of seminars held at the NPD, personnel list and list of published papers are also given. The first, leading article in the report written by head of NPD prof. Ch. Droste the general description of the Department activity is presented.

Nuclear Physics Division, Institute of Experimental Physics, Warsaw University annual report 1995

Energy Technology Data Exchange (ETDEWEB)

Osuch, S. [ed.

1996-12-31

In the presented Annual Report the activities of Nuclear Physics Division (NPD) of Warsaw University in 1995 are described. The report consists of three sections: (i) Reaction Mechanism and Nuclear Structure (11 articles); (ii) Instrumentation and Experimental Methods (9 articles); (iii) Other Research (1 article). Additionally the list of seminars held at the NPD, personnel list and list of published papers are also given. The first, leading article in the report written by head of NPD prof. Ch. Droste the general description of the Department activity is presented.

Determinación experimental de los factores que controlan el desprendimiento de polvos en el conformado de chapas de acero recubiertas con Zn-Ni

Directory of Open Access Journals (Sweden)

Cárcel, A. C.

1995-04-01

Full Text Available Powder detachment from coatings during press forming of Zn-Ni precoated steel sheets increases die wear and maintenance costs. Experimental design helped to establish that powder detachment rises by increasing coating thickness or bath temperature. Otherwise, the use of high flow rates and the presence of an intermediate layer of nickel help to reduce powdering. Temperature and flow rate affect the alloy composition. In the range 10 to 15 % Ni, powdering increases as the alloy becomes richer in nickel. This behaviour is attributed to changes in structure and ductility of the alloy.

El desprendimiento de polvos del recubrimiento durante la embutición constituye uno de los principales problemas en las líneas de prensas que emplean chapas de acero recubiertas con aleaciones Zn-Ni. El uso de técnicas de diseño de experiencias permitió determinar que la cantidad de polvos aumenta al incrementarse el espesor del depósito y la temperatura del baño, y disminuye al aplicar un flash intermedio de níquel o al aumentar la velocidad relativa cátodo-electrólito. Los efectos de la velocidad y de la temperatura afectan a la composición de la aleación. En el rango comprendido entre el 10-15 % Ni, el desprendimiento aumenta con el contenido en níquel, lo que se atribuye a los cambios de estructura y de ductilidad de la aleación.

Determining of the nuclear composition of primary cosmic rays from the experimental distributions of multiple muons in atmospheric showers

International Nuclear Information System (INIS)

Beshtoev, Kh.M.

1993-01-01

Various approaches are discussed for determining the nuclear composition of the primary cosmic radiation from the distributions of multiple muons. Results are presented of calculations of the distributions of multiple muons for A 1 , A 4 , A 14 , A 26 , A 56 nuclei for an infinite plane and for the underground scintillation telescope of the Institute for Nuclear Research of the Academy of Sciences of Russia.The most suitable technique for determination of the primary nuclear composition of cosmic rays from the distribution of multiple muons is shown to be the approximate solution of a set of N equations, in which the respective coefficients of the contributions of various nuclei A i (i=1-N) to the primary composition serve as variables, while the remaining parts of these equations are the distributions of multiple muons obtained experimentally. 7 refs.; 2 tabs

Theoretical and experimental study of the dark signal in CMOS image sensors affected by neutron radiation from a nuclear reactor

Science.gov (United States)

Xue, Yuanyuan; Wang, Zujun; He, Baoping; Yao, Zhibin; Liu, Minbo; Ma, Wuying; Sheng, Jiangkun; Dong, Guantao; Jin, Junshan

2017-12-01

The CMOS image sensors (CISs) are irradiated with neutron from a nuclear reactor. The dark signal in CISs affected by neutron radiation is studied theoretically and experimentally. The Primary knock-on atoms (PKA) energy spectra for 1 MeV incident neutrons are simulated by Geant4. And the theoretical models for the mean dark signal, dark signal non-uniformity (DSNU) and dark signal distribution versus neutron fluence are established. The results are found to be in good agreement with the experimental outputs. Finally, the dark signal in the CISs under the different neutron fluence conditions is estimated. This study provides the theoretical and experimental evidence for the displacement damage effects on the dark signal CISs.

Methods and benefits of experimental seismic evaluation of nuclear power plants. Final report

International Nuclear Information System (INIS)

1979-07-01

This study reviews experimental techniques, instrumentation requirements, safety considerations, and benefits of performing vibration tests on nuclear power plant containments and internal components. The emphasis is on testing to improve seismic structural models. Techniques for identification of resonant frequencies, damping, and mode shapes, are discussed. The benefits of testing with regard to increased damping and more accurate computer models are oulined. A test plan, schedule and budget are presented for a typical PWR nuclear power plant

Methods and benefits of experimental seismic evaluation of nuclear power plants. Final report

Energy Technology Data Exchange (ETDEWEB)

1979-07-01

This study reviews experimental techniques, instrumentation requirements, safety considerations, and benefits of performing vibration tests on nuclear power plant containments and internal components. The emphasis is on testing to improve seismic structural models. Techniques for identification of resonant frequencies, damping, and mode shapes, are discussed. The benefits of testing with regard to increased damping and more accurate computer models are oulined. A test plan, schedule and budget are presented for a typical PWR nuclear power plant.

State of the art of computer codes and experimental investigations on safety of nuclear power plants with reactors of WWER type

International Nuclear Information System (INIS)

Asmolov, V.G.; Volkov, G.A.; Elikin, I.V.; Mysenkov, A.I.

1987-01-01

As is well-known investigations on mathematical models of accidental situations from the point of view of nuclear safety as well as their experimental investigation are of great importance in the design of reactor units for nuclear power plants. This paper gives a review of the state of the art of thermodynamic models and computer codes used for safety analysis of WWER reactors in the USSR, the experimental basis and experimental investigations of the appropriate thermal processes. The actual and future trends of theoretical and experimental investigation on safety problems of WWER type nuclear power plants are briefly described. (author)

Cytotoxic T lymphocyte recognition of HLA-A/B antigens introduced into EL4 cells by cell-liposome fusion.

Science.gov (United States)

Engelhard, V H; Powers, G A; Moore, L C; Holterman, M J; Correa-Freire, M C

1984-01-01

HLA-A2 and -B7 antigens were introduced into EL4 (H-2b) cells by cell-liposome fusion and were used as targets or stimulators for cytotoxic T lymphocytes (CTL) generated in C57B1/6 (H-2b) mice. It was found that such EL4-HLA cells were not recognized by CTL that had been raised against either a human cell line bearing these HLA antigens or the purified HLA-A2 and -B7 antigens reconstituted into liposomes. In addition, EL4-HLA cells were not capable of inducing CTL that could recognize a human cell line bearing HLA-A2 and -B7 antigens. Instead, EL4-HLA cells induced CTL that specifically lysed EL4-HLA cells and not human cells expressing HLA-A2 and -B7. CTL recognition required the presence of HLA antigens on the EL4 cell surface and was inhibited by antibodies against either H-2b or HLA-A/B. Monoclonal antibody binding studies showed that the expected polymorphic determinants of the HLA-A2 and -B7 antigens were still present on EL4-HLA cells. However, the specificity of CTL or their precursors that are capable of recognizing HLA-A2 or -B7 was altered after these antigens became associated with the EL4 surface. Possible explanations for these results are discussed.

Quantification of the validity of simulations based on Geant4 and FLUKA for photo-nuclear interactions in the high energy range

Science.gov (United States)

Quintieri, Lina; Pia, Maria Grazia; Augelli, Mauro; Saracco, Paolo; Capogni, Marco; Guarnieri, Guido

2017-09-01

Photo-nuclear interactions are relevant in many research fields of both fundamental and applied physics and, for this reason, accurate Monte Carlo simulations of photo-nuclear interactions can provide a valuable and indispensable support in a wide range of applications (i.e from the optimisation of photo-neutron source target to the dosimetric estimation in high energy accelerator, etc). Unfortunately, few experimental photo-nuclear data are available above 100 MeV, so that, in the high energy range (from hundreds of MeV up to GeV scale), the code predictions are based on physical models. The aim of this work is to compare the predictions of relevant observables involving photon-nuclear interaction modelling, obtained with GEANT4 and FLUKA, to experimental data (if available), in order to assess the code estimation reliability, over a wide energy range. In particular, the comparison of the estimated photo-neutron yields and energy spectra with the experimental results of the n@BTF experiment (carried out at the Beam Test Facility of DaΦne collider, in Frascati, Italy) is here reported and discussed. Moreover, the preliminary results of the comparison of the cross sections used in the codes with the"evaluated' data recommended by the IAEA are also presented for some selected cases (W, Pb, Zn).

[Experimental nuclear physics

International Nuclear Information System (INIS)

1990-04-01

This report contains brief discussion on the following tapes: giant resonances; nucleus-nucleus reactions; nuclear astrophysics; polarization; fundamental symmetries and interactions; accelerator mass spectrometry; instrumentation; accelerators and in sources; and computer systems

The stimulation of EL-4 cells to produce interleukin-2 and its potential use in immunocytotoxicity testing

International Nuclear Information System (INIS)

Lasek, W.; Steer, S.; Clothier, R.; Balls, M.

1989-01-01

The ability of EL-4 thymoma cells to produce interleukin-2 (IL-2) following exposure to phorbol-12-myristate 13-acetate (PMA) and Concanavalin A (Con A) has been studied in vitro using medium containing either 10% or 1% fetal calf serum (FCS). The potent stimulatory effect of PMA on IL-2 production by EL-4 cells has been confirmed by measuring 3H-thymidine incorporation by the IL-2-dependent T cell line, CTLL-2, in the presence of conditioned medium (CM) from stimulated cultures. EL-4 cells produced several times more IL-2 when cultured in medium containing 10% FCS than when only 1% FCS was present. Added together, PMA and Con A acted synergistically in some EL-4 cell cultures. The ability of E:-4 cells to produce IL-2 was maintained after further incubation without stimulants. CM with IL-2 activity from stimulated EL-4 cells could prove useful in immunotoxicity testing

Experimental and analytical studies for a BWR nuclear reactor building evaluation of soil-structure interaction behavior

International Nuclear Information System (INIS)

Mizuno, N.; Tsushima, Y.

1975-01-01

The purpose of this paper is to evaluate the spatial characteristics of dynamic properties, especially soil-structure interaction behavior, or the BWR nuclear reactor building by experimental and analytical studies. An analytical method (SMIRT-1 Paper K 2/4) for estimating the damping effects is reported. The complex damping is used, because the so-called structural damping may be more suitable for estimating the damping effects of an elastic structure. H. Tajimi's theory is used for estimating the dynamical soil-foundation stiffness with the dissipation of vibrational energy on the elastic half-space soil. An approximate explanation is presented in regard to the more developmental mathematical method for estimating the damping effects than the above-mentioned previous method, which is 'Modes Superposition Method for Multi-Degrees of Freedom System' with the constant complex stiffness showing the structural damping effects and the dynamical soil-foundation stiffness approximated by the linear or quadratic functions of the eigenvalues. Next, an approximate explanation is presented in regard to the experimental results of the No.1 reactor building (BWR) of Hamaoka Nuclear Power Station, The Chubu Electric Power Co., Ltd. The regression analyses of the experimental resonance curves by one degree system show that the critical damping ratio is larger than the 0.10 used in the design for the fundamental natural period. It is attempted to simulate the experimental results by the above-mentioned method. The simulated model is a fourty-eight degrees of freedom spring mass system because of the eight masses for the eight floors including the base foundation and the six degrees of freedom for a mass

Characterisation of large area THGEMs and experimental measurement of the Townsend coefficients for CF4

Science.gov (United States)

Burns, J.; Crane, T.; Ezeribe, A. C.; Grove, C. L.; Lynch, W.; Scarff, A.; Spooner, N. J. C.; Steer, C.

2017-10-01

Whilst the performance of small THGEMs is well known, here we consider the challenges in scaling these up to large area charge readouts. We first verify the expected gain of larger THGEMs by reporting experimental Townsend coefficients for a 10 cm diameter THGEM in low-pressure CF4. Large area 50 cm by 50 cm THGEMs were sourced from a commercial PCB supplier and geometrical imperfections were observed which we quantified using an optical camera setup. The large area THGEMs were experimentally characterised at Boulby Underground Laboratory through a series of gain calibrations and alpha spectrum measurements. ANSYS, Magboltz and Garfield++ simulations of the design of a TPC based on the large area THGEMs are presented. We also consider their implications for directional dark matter research and potential applications within nuclear security.

Program PLOTC4. (Version 87-1). Plot evaluated data from the ENDF/B format and/or experimental data which is in a computation format

International Nuclear Information System (INIS)

Cullen, D.E.

1987-06-01

Experimental and evaluated nuclear reaction data are world-wide compiled in EXFOR format (see document IAEA-NDS-1) and ENDF format (see document IAEA-NDS-10), respectively. The computer program PLOTC4 described in the present document plots data from both formats; EXFOR data must be converted first to a ''computation format'' (see document IAEA-NDS-80). The program is available upon request costfree from the IAEA Nuclear Data Section. (author)

The Physical Protection of Nuclear Material; Proteccion Fisica Delos Materiales Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-09-15

Physical protection against the theft or unauthorized diversion of nuclear materials and against the sabotage of nuclear facilities by individuals or groups has long been a matter of national and international concern. Although responsibility for establishing and operating a comprehensive physical protection system for nuclear materials and facilities within a State rests entirely with the Government of that State, it is not a matter of indifference to other States whether and to what extent that responsibility is fulfilled. Physical protection has therefore become a matter of international concern and co-operation. The need for international cooperation becomes evident in situations where the effectiveness of physical protection in one State depends on the taking by other States also of adequate measures to deter or defeat hostile actions against nuclear facilities and materials, particularly when such materials are transported across national frontiers [French] La proteccion fisica contra el robo o la desviacion no autorizada de materiales nucleares y contra el sabotaje de las instalaciones nucleares por parte de individuos o de grupos ha sido durante largo tiempo motivo de preocupacion nacional e internacional. Aunque la obligacion de crear y hacer funcionar un sistema completo de proteccion fisica para las instalaciones y materiales nucleares en el territorio de un Estado determinado incumbe enteramente al Gobierno de dicho Estado, el que esa obligacion se cumpla o no, y si se cumple, en que medida o hasta que punto, es cosa que no deja indiferentes a los demas Estados. De aqui que la proteccion fisica se haya convertido en motivo de interes y cooperacion internacional. La necesidad de cooperacion internacional se hace evidente en los casos en que la eficacia de la proteccion fisica en el territorio de un Estado depende de que otros Estados tomen tambien medidas apropiadas para evitar o hacer fracasar los actos hostiles dirigidos contra instalaciones y

Computer-readable ''Nuclear Data Sheets''

International Nuclear Information System (INIS)

Ewbank, W.B.

1975-01-01

The evaluated nuclear structure data contained in ''Nuclear Data Sheets'' are available in computer-readable form. Experimentally established properties of nuclear levels are included as well as radiations from nuclear reactions and radioactive decay. Portions of the data can be selected for distribution in several formats on magnetic tape or computer cards. A variety of different listing and drawing formats are also available. 4 figures

Algoritmo para el 4ap haciendo uso de la metaheuristica sistema hormiga

Directory of Open Access Journals (Sweden)

Manuel Vicente Centeno Romero

2008-07-01

Full Text Available La metaheurística sistema hormiga consiste en la analogía entre el procedimiento que utilizan las hormigas reales para la búsqueda de alimentos, encontrando la ruta más corta, y los problemas de optimización combinatoria para encontrar la mejor solución. Entre estos problemas se encuentra el de asignación multidimensional (mAP, el cual es un problema NP-difícil para m > 2. En la actualidad no se ha desarrollado trabajo alguno sobre el 4AP (mAP con m=4, tampoco existe publicación sobre la aplicación del sistema hormiga para el mAP. En este trabajo se desarrolló un software que hace uso de la metaheurística sistema hormiga para encontrar la mejor solución o aproximada al 4AP, con problemas generados aleatoriamente. Se implementó una metodología híbrida entre la metodología de Investigación de Operaciones descrita por Taha (1991 y la ingeniería de software (1990. El número de asignaciones tomadas en cuenta para verificar qué tan buenas son las soluciones arrojadas por el software, varía desde n=2 hasta n=25, obteniéndose soluciones exactas para 2 £ n £ 6, ya que al compararse dichas soluciones con las dadas por XPRESS (software de programación lineal que se usa para resolver modelos matemáticos se observa la igualdad en los resultados. Para n _ 7, XPRESS (la versión utilizada no ofrece respuesta alguna, pero el software desarrollado arroja buenos resultados en un tiempo computacional razonable, considerando el número de asignaciones que se procesan en cada n. The metaheuristic ant system consists on the analogy among the procedure used by the real ants for searching food, for finding the shortest route; and the problems of combinatoria optimization to find the best solution. Among these problems we can find the multidimensional assignment problem (mAP, which is a NP-difficult problem for m > 2. At the present time, there isn‘t any work that has been developed, on this topic about the 4AP (mAP with m=4, neither

Nuclear magnetic resonance. Present results and its application to renal pathology. Experimental study of hydronephrosis

International Nuclear Information System (INIS)

Bertrand, P.

1987-01-01

Results of proton nuclear magnetic resonance imaging and relaxation time measurement of experimental hydronephrosis in mice are presented. The study is preceded by a description of the physical principles underlying the phenomenon of nuclear magnetic resonance and of its biomedical applications and with a review of the clinical use of NMR imaging in renal pathology [fr

Experimental and computational investigation of flow of pebbles in a pebble bed nuclear reactor

Science.gov (United States)

Khane, Vaibhav B.

The Pebble Bed Reactor (PBR) is a 4th generation nuclear reactor which is conceptually similar to moving bed reactors used in the chemical and petrochemical industries. In a PBR core, nuclear fuel in the form of pebbles moves slowly under the influence of gravity. Due to the dynamic nature of the core, a thorough understanding about slow and dense granular flow of pebbles is required from both a reactor safety and performance evaluation point of view. In this dissertation, a new integrated experimental and computational study of granular flow in a PBR has been performed. Continuous pebble re-circulation experimental set-up, mimicking flow of pebbles in a PBR, is designed and developed. Experimental investigation of the flow of pebbles in a mimicked test reactor was carried out for the first time using non-invasive radioactive particle tracking (RPT) and residence time distribution (RTD) techniques to measure the pebble trajectory, velocity, overall/zonal residence times, flow patterns etc. The tracer trajectory length and overall/zonal residence time is found to increase with change in pebble's initial seeding position from the center towards the wall of the test reactor. Overall and zonal average velocities of pebbles are found to decrease from the center towards the wall. Discrete element method (DEM) based simulations of test reactor geometry were also carried out using commercial code EDEM(TM) and simulation results were validated using the obtained benchmark experimental data. In addition, EDEM(TM) based parametric sensitivity study of interaction properties was carried out which suggests that static friction characteristics play an important role from a packed/pebble beds structural characterization point of view. To make the RPT technique viable for practical applications and to enhance its accuracy, a novel and dynamic technique for RPT calibration was designed and developed. Preliminary feasibility results suggest that it can be implemented as a non

Análisis de las sanciones internacionales en el marco del tratado de no proliferación nuclear. Estudio de caso: energía atómica en Irán (2006-2015)

OpenAIRE

Góngora Celedón, Juan Camilo

2016-01-01

El presente trabajo de Grado tiene como propósito examinar la incidencia de las sancionesinternacionales en el marco del régimen de no proliferación nuclear en el caso de Irán durante el periodo 2006-2015, teniendo en cuenta factores históricos de años anteriores. Se analiza y explica cómo las sanciones internacionales pueden ser una medida persuasiva por violar ciertos artículos del Tratado de no Proliferación Nuclear. Finalmente identifica y analiza los tipos de sanciones económicas, finan...

The international thermonuclear experimental reactor and the future of nuclear fusion energy

International Nuclear Information System (INIS)

Pan Chuanhong

2010-01-01

Energy shortage and environmental problems are now the two largest challenges for human beings. Magnetic confinement nuclear fusion, which has achieved great progress since the 1990's, is anticipated to be a way to realize an ideal source of energy in the future because of its abundance, environmental compatibility, and zero carbon release. Exemplified by the construction of the International Thermonuclear Experimental Reactor (ITER), the development of nuclear fusion energy is now in its engineering phase, and should be realized by the middle of this century if all objectives of the ITER project are met. (author)

Comprehensive Characterization of Palygorskite from Torrejon el Rubio (Spain) Based on Experimental Techniques and Theoretical DFT Studies

International Nuclear Information System (INIS)

Fernandez, A.M.; Timon, V.; Cubero, J. J.; Sanchez-Ledesma, D. M.; Gutierrez-Nebot, L.; Martinez, J. J.; Romero, C.; Labajo, M.; Melon, A.; Barrios, I.

2013-01-01

New data about the physico-chemical, microstructural and crystal-chemical properties of the mineral paligorskite from Torrejon el Rubio (Caceres, Spain) were obtained by a combination of experimental techniques (XRD, FRX, FTIR, TG-DSC, SEM and chemical analyses), as well as geometry optimization by means of the Density Functional Theory (DFT). This study demonstrates the applicability of the mixed theoretical-experimental work to characterize and understand the properties of clay minerals used in technological applications and environmental remediation. (Author)

Comprehensive Characterization of Palygorskite from Torrejon el Rubio (Spain) Based on Experimental Techniques and Theoretical DFT Studies

Energy Technology Data Exchange (ETDEWEB)

Fernandez, A.M.; Timon, V.; Cubero, J. J.; Sanchez-Ledesma, D. M.; Gutierrez-Nebot, L.; Martinez, J. J.; Romero, C.; Labajo, M.; Melon, A.; Barrios, I.

2013-10-01

New data about the physico-chemical, microstructural and crystal-chemical properties of the mineral paligorskite from Torrejon el Rubio (Caceres, Spain) were obtained by a combination of experimental techniques (XRD, FRX, FTIR, TG-DSC, SEM and chemical analyses), as well as geometry optimization by means of the Density Functional Theory (DFT). This study demonstrates the applicability of the mixed theoretical-experimental work to characterize and understand the properties of clay minerals used in technological applications and environmental remediation. (Author)

Nuclear Physics Laboratory. Annual report no.21

International Nuclear Information System (INIS)

1986-11-01

The annual report of the Nuclear Physics Laboratory covers the following subjects: 1) the accelerators; 2) work in experimental nuclear physics; 3) research in particle physics: experiments at TRIUMF and CERN; 4) work in applied nuclear physics; and 5) work in theoretical physics

Nuclear Physics Laboratory. Annual report no.22

International Nuclear Information System (INIS)

1987-11-01

The annual report of the Nuclear Physics Laboratory covers the following subjects: 1) the accelerators; 2) work in experimental nuclear physics; 3) research in particle physics: experiments at TRIUMF and CERN; 4) work in applied nuclear physics; and 5) work in theoretical physics

Nuclear energy. The innovations of the N4 reactor

International Nuclear Information System (INIS)

Anon.

1998-01-01

The coupling to the electric network of the two first units of N4 type reactors, on the site of Chooz in the Ardennes, marks the third great step of the French nuclear programme of PWR type reactors, after the realization of 34 units of 900 MWe and 20 units of 1300 M We. The nuclear boiler N4, realizes a new evolution in power, in performances and in reliability. (N.C.)

Differential Expression of Ccn4 and Other Genes Between Metastatic and Non-metastatic EL4 Mouse Lymphoma Cells.

Science.gov (United States)

Chahal, Manpreet S; Ku, H Teresa; Zhang, Zhihong; Legaspi, Christian M; Luo, Angela; Hopkins, Mandi M; Meier, Kathryn E

Previous work characterized variants of the EL4 murine lymphoma cell line. Some are non-metastatic, and others metastatic, in syngenic mice. In addition, metastatic EL4 cells were stably transfected with phospholipase D2 (PLD2), which further enhanced metastasis. Microarray analyses of mRNA expression was performed for non-metastatic, metastatic, and PLD2-expressing metastatic EL4 cells. Many differences were observed between non-metastatic and metastatic cell lines. One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistry. Other differentially expressed genes included those for reproductive homeobox 5 (Rhox5; increased in metastatic) and cystatin 7 (Cst7; decreased in metastatic). Differences between PLD2-expressing and parental cell lines were limited but included the signaling proteins Ras guanyl releasing protein 1 (RGS18; increased with PLD2) and suppressor of cytokine signaling 2 (SOCS2; decreased with PLD2). The results provide insights into signaling pathways potentially involved in conferring metastatic ability on lymphoma cells. Copyright© 2016, International Institute of Anticancer Research (Dr. John G. Delinasios), All rights reserved.

Preface: Eighth European Summer School on Experimental Nuclear Astrophysics

International Nuclear Information System (INIS)

Claudio, Spitaleri; Livio, Lamia; Gianluca, Pizzone Rosario

2016-01-01

In this book a collection of the lecture notes given during the Eighth European Summer School on Experimental Nuclear Astrophysics is given. The school, whose first edition was first held in 2003, took place from 13 to 20 of September 2015 in Santa Tecla, a small village about 15 km north of Catania, characterized by its position on the volcanic shores of the Ionian Sea, surrounded by the spectacular “Timpa” area, a green protected park specific for its mediterranean vegetation. 80 young students and researchers from more than 20 countries attended the lectures and were also encouraged to present their work and results. The school, has tried once more to present to the young students the global picture of nuclear astrophysics research in the last years. Thus the scientific program of the school covered a wide range of topics dealing with various aspects of nuclear astrophysics, such as stellar evolution and nucleosynthesis, neutrino physics, the Big Bang, direct and indirect methods and radioactive ion beams. Nuclear astrophysics plays a key role in understanding energy production in stars, stellar evolution and the concurrent synthesis of the chemical elements and their isotopes. It is also a fundamental tool to explain the ashes of the early universe, to determine the age of the universe through the study of pristine stellar objects and to predict the evolution of the Sun or Stars. The “bone structure” for the above aspects is based on nuclear reactions, whose rates need to be determined in laboratories. Although impressive progress has been made over the past decades, which was rewarded by Nobel prizes, several open questions are still unsolved, which challenge the basis of the present understanding. A list of the lecture topics is given below: —Big Bang Nucleosynthesis —Stellar evolution and Nucleosynthesis —radioactive ion beams —detector and facilities for nuclear astrophysics —indirect methods in nuclear astrophysics —plasma physics An

Building tomorrow's nuclear power plants with 4+D VR technology

International Nuclear Information System (INIS)

Lee, Il S.; Yoon, Sang H.; Shim, Kyu W.; Yu, Yong H.; Suh, Kune Y.

2002-01-01

There continues to be an increasing demand of electricity around the globe to fuel the industrial growth and to promote the human welfare. The economic activities have brought about richness in our material and cultural lives, in which process the electric power has been at the heart of the versatile energy sources. In order to timely and competitively respond to rapidly changing energy environment in the twenty-first century there is a growing need to build the advanced nuclear power plants in the unlimited workspace of virtual reality (VR) prior to commissioning. One can then realistically evaluate their construction time and cost per varying methods and options available from the leading-edge technology. In particular a great deal of efforts have yet to be made for time- and cost-dependent plant simulation and dynamically coupled database construction in the VR space. The operator training and personnel education may also benefit from the VR technology. The present work is being proposed in the three-dimensional space and time plus cost coordinates, i. e. four plus dimensional (4 + D) coordinates. The 4 + D VR application will enable the nuclear industry to narrow the technological gap from the other leading industries that have long since been employing the VR engineering. The 4 + D technology will help nurture public understanding of the special discipline of nuclear power plants. The technology will also facilitate public access to the knowledge on the nuclear science and engineering which has so far been monopolized by the academia, national laboratories and the heavy industry. The 4 + D virtual design and construction will open up the new horizon for revitalization of the nuclear industry over the globe in the foreseeable future. Considering the long construction and operation time for the nuclear power plants, the preliminary VR simulation capability for the plants will supply the vital information not only for the actual design and construction of the

Los primeros pasos en la organización de la lucha contra el cáncer en la Argentina: el papel del Instituto de Medicina Experimental, 1922-1947

Directory of Open Access Journals (Sweden)

Buschini, José

2016-06-01

Full Text Available This article analyses initiatives to organize the fight against cancer in Argentina between the early 1920s to mid 1940s. Specifically, it focuses on the initiatives of the Instituto de Medicina Experimental, a hospital-research institute dependent on the Facultad de Ciencias Médicas of the Universidad de Buenos Aires that played a key role in this process. This paper considers the organization of the medical attention within the establishment, knowledge awareness campaigns, and the intents to incorporate cancer as a topic in the professional curricula and scientific research linking cancer and life styles.El artículo analiza iniciativas para organizar la lucha contra el cáncer en la Argentina entre comienzos de la década de 1920 y mediados de la década de 1940. En particular, hace eje en las acciones del Instituto de Medicina Experimental, un hospital-instituto de investigación dependiente de la Facultad de Ciencias Médicas de la Universidad de Buenos Aires que tuvo un papel central en este proceso. Se presta atención a la organización de la atención médica en el establecimiento, a las campañas de difusión de conocimiento a la población, a los intentos por incorporar esta cuestión a la formación profesional, a la articulación de las actividades con organismos estatales para dar mayor alcance territorial a la lucha contra el cáncer y a las investigaciones científicas que apuntaron a vincular el desarrollo del cáncer con estilos de vida.

ESTRUCTURA TRIDIMENSIONAL DEL a-CICLOPROPIL- (p-METOXIFENIL-5-PIRIMIDINMETANOL (ANCIMIDOL UTILIZANDO EL MÉTODO DE RESONANCIA MAGNÉTICA NUCLEAR

Directory of Open Access Journals (Sweden)

O. Ospina

2005-12-01

Full Text Available El Ancimidol, α-ciclopropil-(p-metoxifenil-5-pirimidinmetanol, (C15H16N2O2 es un regulador de crecimiento vegetal sintético, que hace parte del grupo de compuestos heterocíclicos que contienen nitrógeno que inhiben la síntesis de las giberelinas. La estructura de esta molécula se determinó por resonancia magnética nuclear, partiendo de una solución en cloroformo deuterado (CDCl3, utilizando un espectrómetro de 500MHz (campo de 11.7Teslas. Se tomaron espectros unidimensionales RMN 1H, RMN 13C, pruebas DEPT 45, 90 y 135 y espectros bidimensionales HMBC y HMQC. En la estructura obtenida para el Ancimidol, se observaron tres ciclos como son la pirimidina, el metoxifenilo y el ciclopropilo, identi-ficados por la asignación de los átomos de hidrógeno y de carbono y por las relaciones de conectividad dadas por los espectros bidimensionales HMBC y HMQC.

Evaluación y estandarización del análisis por activación neutrónica según el método del k-sub cero en el reactor nuclear RP-10: Estudio preliminar empleando irradiaciones cortas

OpenAIRE

Montoya Rossi, Eduardo Haroldo

1995-01-01

Se ha estandarizado una posición de irradiación del reactor nuclear RP-10 para el uso del análisis por activación neutrónica según el método del k sub cero, empleando la convención de Högdahl y se ha evaluado el comportamiento de dicho método respecto a la exactitud y precisión de los resultados obtenidos en el análisis multielemental cuantitativo de diversos materiales certificados de referencia. Para comprobar que el método analítico se encuentra totalmente bajo control estadístico, se ha e...

Combined conditioning in the high-temperature experimental nuclear reactor (AVR) at Juelich

International Nuclear Information System (INIS)

Nieder, R.; Vey, K.; Ivens, G.

1984-01-01

The high temperature experimental nuclear reactor (AVR) is the first nuclear power plant in which combined cycle operation has been introduced. The water-steam cycle has been operated for about 15 years according to the alkali method of working with ammonia and hydrazine. The VGB-guidelines have been adhered to througout. Since January 1983 cobined cycle operation has been employed, and in this process a pH-value of about 8.5 and an oxygen concentration of about 200 μg/kg in the feedwater have been used. A distinct reduction of tritium concentration in the water-steam cycle was the outstanding new result. (orig.) [de

Proceedings of the 4. General Congress on Nuclear Energy. v. 1

International Nuclear Information System (INIS)

1992-01-01

The first volume of the 4. General Congress on Nuclear Energy presents works about transient and accident analysis; thermohydraulics; radioisotopes uses; fuel cycle; shield; material technology; nuclear installation construction and reactor and nuclear physics. (C.G.C.)

Coeficientes de transferencia de calor experimental para el enfriamiento de licor en intercambiadores de placas//Experimental heat transfer coefficients for the liquor cooling in plate heat exchanger

Directory of Open Access Journals (Sweden)

Enrique Torres‐Tamayo

2014-01-01

Full Text Available La pérdida de eficiencia del proceso de enfriamiento del licor amoniacal, mediante el uso de intercambiadores de calor de placas, está asociada a imprecisiones en la estimación de los coeficientes de transferencia de calor y la acumulación de incrustaciones en la superficie de intercambio. El objetivo de la investigación es determinar los coeficientes de transferencia de calor y la influencia de lasincrustaciones en la pérdida de eficiencia de la instalación. Mediante un procedimiento iterativo se estableció la ecuación del número de Nusselt y su relación con el número de Reynolds y Prandtl. Se utilizó un diseño experimental multifactorial. Los resultados predicen el conocimiento de los coeficientespara el cálculo del número de Nusselt en ambos fluidos. Los valores de los coeficientes del licor amoniacal son inferiores, ello se debe a la presencia de componentes gaseosos. La ecuación obtenida muestra correspondencia con el modelo de Buonapane, el error comparativo es del 3,55 %.Palabras claves: intercambiador de calor de placas, coeficientes de transferencia de calor, eficiencia térmica.______________________________________________________________________________AbstractThe loss of efficiency of the ammonia liquor cooling process, by means of the plate heat exchanger, is associated to the incorrect estimate of the heat transfer coefficients and the accumulation of inlays in the exchange surface. The objective of the investigation is to determine the transfer coefficients and the influence of the inlays in the efficiency loss of the installation. By means of an iterative procedure was obtained the Nusselt number equation and the relationship with the Reynolds and Prandtl number, for it was used it a design experimental multifactorial. The results predict the knowledge of the coefficients forthe calculation of the Nusselt number for both fluids. The ammonia liquor coefficients values are inferior, due to the presence of gassy

Elastic scattering analysis of p + 40Ca at incident energies from threshold to 48.4 MeV and nuclear matter radius

International Nuclear Information System (INIS)

Ismail, Atef; Lee, Yen Cheong; Tammam, M.

2015-01-01

Proton elastic scattering at various incident energies is one method to study nuclear density distributions and nuclear radii. Single folding potential describing the p-scattering on 40 Ca over a broad energy range 9–48.4 MeV is constructed. The resulting potential does not need any renormalization to fit the measured elastic scattering angular distributions and total reaction cross-sections. Furthermore, correlation between volume integral and proton incident energy is discussed. Theoretical calculations are in a good agreement with existing experimental data. (author)

Protocol Additional to the Agreement between the Government of the Republic of Ghana and the International Atomic Energy Agency for the Application of Safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons; Protocolo Adicional Al Acuerdo Entre La Republica De Ghana Y El Organismo Internacional De Energia Atomica Para La Aplicacion De Salvaguardias En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-11-27

The text of the Protocol Additional to the Safeguards Agreement concluded between the Government of the Republic of Ghana and the International Atomic Energy Agency for the application of safeguards in connection with the Treaty for the Non-Proliferation of Nuclear Weapons (NPT) is reproduced in this document for the information of all Members. The Additional Protocol was approved by the Board of Governors on 11 June 1998. It was signed in Vienna on 12 June 1998 [Spanish] Se transcribe en el presente documento, para informacion de todos los Estados Miembros, el texto del Protocolo adicional al Acuerdo de salvaguardias concertado entre la Republica de Ghana y el Organismo Internacional de Energia Atomica para la aplicacion de salvaguardias en relacion con el Tratado sobre la no proliferacion de las armas nucleares (TNP). El Protocolo adicional fue aprobado por la Junta de Gobernadores el 11 de junio de 1998 y firmado en Viena el 12 de junio de 1998.

Sophisticated visualization algorithms for analysis of multidimensional experimental nuclear spectra

International Nuclear Information System (INIS)

Morhac, M.; Kliman, J.; Matousek, V.; Turzo, I.

2004-01-01

This paper describes graphical models of visualization of 2-, 3-, 4-dimensional scalar data used in nuclear data acquisition, processing and visualization system developed at the Institute of Physics, Slovak Academy of Sciences. It focuses on presentation of nuclear spectra (histograms). However it can be successfully applied for visualization of arrays of other data types. In the paper we present conventional as well as new developed surface and volume rendering visualization techniques used (Authors)

Introduction to Nuclear Physics (4/4)

CERN Multimedia

CERN. Geneva

2008-01-01

This lecture will be an introduction to the open questions and key issues on the properties and structure of atomic nuclei and nuclear matter. No particular prerequisite. It might be interesting to give a look to an introduction to nuclear physics. A look at the web might give the students an ...

Decree no. 96-978 from October 31, 1996 giving permission to the French atomic energy Commission (CEA) to create a basic nuclear installation intended to maintain under supervision and in an intermediate dismantling state the old basic nuclear installation no. 28, named Monts d'Arree-EL 4 nuclear power plant (a decommissioned reactor), in the Monts d'Arree site of the Loqueffret town (Finistere, Brittany)

International Nuclear Information System (INIS)

Borotra, F.; Lepage, C.

1996-01-01

This decree from the French ministry of industry and postal services gives permission to the CEA to create a new basic nuclear installation, named EL 4D, which is devoted to the storage of materials from the partially dismantled Monts d'Arree EL 4 reactor. Thus, the CEA is allowed to carry out confining works on the reactor building with the closure of all apertures with the exception of the personnel entry sieve, on the circuits and equipments of the reactor vessel with the plugging of fuel channels, heavy water, helium and demineralized water pipes and of the heads of control rod drive mechanisms and other channels, and on the primary coolant circuit outside the reactor vessel and the steam generators with the installation of welded hatches. The irradiated fuels building, the solid wastes repository, the ventilation building, the heavy water and helium circuits, the fuel handling systems and the effluents treatment plant will be completely dismantled. The other buildings will be pulled down. The rest of the decree enumerates the general technical and safety prescriptions which have to be followed in order to ensure the protection of the personnel against ionizing radiations and of the environment against radioactive pollution. (J.S.)

Phorbol esters induce interleukin 2 mRNA in sensitive but not in resistant EL4 cells

International Nuclear Information System (INIS)

Harrison, J.R.; Lynch, K.R.; Sando, J.J.

1986-01-01

Phorbol ester (PE) sensitive EL4 cells are growth-inhibited and produce interleukin 2 (IL2) when treated with PE. Resistant EL4 cells lack both responses. To determine whether the defect in resistant cells occurs pre or post-transcriptionally, an assay for IL2 mRNA was developed using a synthetic oligonucleotide to mouse IL2 as a probe. Total RNA (15 μg) from cells +/- PE was electrophoresed, blotted onto a cationic nylon membrane, and probed with radiolabeled oligomer. This probe hybridized to a 1.1 kb band in RNA from PE-treated sensitive cells. This RNA was detectable within 3h of PE administration, was clearly visible by 6h, and peaked by 9 to 12h. No bands hybridizing with the IL2 probe were detected in RNA isolated from unstimulated cells or from resistant EL4 cells at any time following PE stimulation. Since levels of the protooncogene c-myc have been shown to decrease in a number of cell lines during differentiation and growth inhibition, total RNA from EL4 cells was probed with a nick-translated plasmid containing the protein coding region of the c-myc gene. In PE sensitive cells, levels of c-myc RNA are markedly reduced by 3h. In a pilot experiment with resistant cells, c-myc levels appeared to remain constant. These results demonstrate that PE induced IL2 mRNA in PE sensitive but not resistant EL4 cells. Sensitive and resistant EL4 cell lines provide a useful model for the investigation of the regulation of gene expression by PE

Análisis de confiabilidad y riesgo de una instalación experimental para el tratamiento de aguas residuales//Reliability and risk analysis of an experimental set-up for wastewater treatment

Directory of Open Access Journals (Sweden)

María Adelfa Abreu‐Zamora

2014-01-01

Full Text Available Una de las exigencias modernas para el uso de equipos en todas las ramas de la economía, la ciencia y la educación, es su explotación segura. En este trabajo, se realizó el análisis de confiabilidad y riesgo de una instalación experimental para el tratamiento de aguas residuales con radiación ultravioleta. Se empleó la técnica del árbol de fallos y se analizaron dos variantes de cálculo. La primera variante consideró fuentes no confiables de suministro de energía eléctrica y la segunda consideró la existencia de fuentes confiables. Como resultado se identificaron 20 conjuntos mínimos de corte, 12 de primer orden y 8 de tercer orden. Además, se infirió, la necesidad de contar con una fuente alternativa de electricidad y que esimportante establecer redundancia de grupo de componentes para instalaciones a escala industrial. El análisis demostró que la instalación es segura para su uso en la experimentación a escala de laboratorio.Palabras claves: confiabilidad, riesgo, instalación experimental, tratamiento de aguas residuales, radiación ultravioleta, árbol de fallos.______________________________________________________________________________AbstractOne of the modern requirements for using equipments in all the areas of economy, science and education, is its safety operation. In this work, it was carried out the reliability and risk analysis of an experimental setup for the wastewater treatment with ultraviolet radiation. The fault tree technique was used and two variants of calculation were analyzed. The first variant considered unreliable sources of electricity supply and the second considered the existence of reliable sources. As a result, 20 minimal cut sets were identified 12 of first-order and 8 of third-order. Besides, the necessity of an alternative supply electrical power source was inferred and it is important to establish redundant components group for industrial scalefacilities. The analysis demostrated the set

LA NECESIDAD DE UNIFICAR LA PSICOLOGIA: EL PARADIGMA DE LA SINTESIS EXPERIMENTAL DEL COMPORTAMIENTO

Directory of Open Access Journals (Sweden)

Rubén Ardila

2003-07-01

Full Text Available Se analizan los orígenes de la psicología en las preocupaciones iniciales del hombre acerca de su comportamiento y del de las demás personas. Tales problemas interesaron a pensadores tan disímiles como Aristóteles, Kant, Wundt, Freud, Watson, Piaget y Skinner. El paso de los problemas psicológicos de la metafísica a la ciencia representó una importante revolución conceptual. En psicología se ha enfatizado en los últimos cien años la objetividad científica y la experimentación. Una de las alternativas más importantes desde el punto de vista metodológico ha sido el operacionalismo, cuyos elementos positivos y negativos se analizan. Las ‘escuelas’ psicológicas —análogas a los paradigmas de Kuhn— han representado diferentes marcos conceptuales sobre la naturaleza de la psicología. Hoy no hay escuelas sino sistemas, más reducidos y menos dogmáticos. Se considera que la síntesis experimental del comportamiento, cuyas características se presentan, puede llegar a ser un paradigma unificador para toda la psicología.

El ecobarrio: proyecto de sensibilización ambiental. El caso de Villa 4 Álamos de Maipú (Chile)

OpenAIRE

Ubeira, Felipe; Quiroga, Carolina

2001-01-01

En la presente investigación se analizaron las consecuencias que ha tenido el desarrollo del primer proyecto de eco barrio en los habitantes de la villa 4 Álamos de Maipú, en la ciudad de Santiago de Chile. El proyecto es impulsado por la organización comunitaria “Ceibo”, integrada por habitantes de la villa, quienes tras enfrentarse a varios conflictos medioambientales y problemas sociales de distinto tipo, han ido en busca de nuevas maneras de habitar la ciudad, debiendo lidiar con factores...

[Experimental nuclear physics

International Nuclear Information System (INIS)

1992-01-01

An earlier study of unusual electromagnetic decays in 86 Zr was extended in order to make comparisons with its isotone 84 Sr and with 84 Zr. The K=14 (t 1/2 = 70 ns) high-spin isomer in 176 W was found to have a 13% branch directly to the K=O ground-state band, one of the strongest violations of K-selection rules known. A new program to search for a predicted region of oblate deformation involving neutron deficient isotopes in the Rn/Fr/Ra region was begun. In the area of nuclear astrophysics, as part of a study of the onset of the rp-Process, a set of measurements searching for possible new resonances for 14 O+α and 17 F+p reactions was completed and a coincidence experiment measuring the 19 F( 3 He,t) 19 Ne(α) 15 O and 19 F( 3 He,t) 19 Ne(p) 18 F reactions in order to determine the rates of the 18 F(p,α) 15 O and 18 F(p,γ) 19 Ne reactions was begun. Experimental measurements of βnα coincidences from the 15 N(d,p) 16 N(β - ν) 16 O(α) 12 C reaction have also been completed and are currently being analyzed to determine the rate of the 12 C(α,γ) reaction. In the APEX collaboration, we have completed the assembly and testing of two position-sensitive Na barrels which surround the axial silicon detector arrays and serve as the e + triggers by detecting their back-to-back annihilation quanta were completed. The HI at sign AGS and RHIC collaborations, construction and implementation activities associated with the space-time-tracker detector and in the design of the central detector for the PHENIX experiment were carried out. Operation of the ESTU tandem accelerator has been reliable, delivering beam on target at terminal voltages as high as 19.3 MV and running for as long as 143 days between tank openings. Fabrication and bench testing of a new negative ion source system have been completed

Aero thermal test results obtained on the n. C 5 EL 4 Cluster in the atmospheric pressure cell

International Nuclear Information System (INIS)

Gasc, B.

1964-01-01

In the framework of thermal studies on the EL-4 cluster, the full-scale tests at atmospheric pressure are designed to permit measurement of local values of the wall temperature, of the velocity and of the temperature in the fluid. The experimental results, obtained with the help of an original measuring apparatus, make it possible to follow the changes in these values along the cluster and to predict in much detail the in-pile thermal behaviour. In particular it is shown that changes in the wall temperature along the cluster are greatly influenced by disruption of the flow caused by grids and supports. (author) [fr

2010 ANNUAL MEETING ON NUCLEAR TECHNOLOGY. Pt. 4. Section reports

International Nuclear Information System (INIS)

Berlepsch, Thilo v.; Hering, Wolfgang

2011-01-01

Summary report on 2 Sessions of Section: - New Build and Innovations (Section 12) of the ANNUAL MEETING On NUCLEAR TECHNOLOGY held in Berlin on May 4 to 6, 2010. The other Sections 'Reactor Physics and Methods of Calculation (Section 1)', 'Thermodynamics and Fluid Dynamics (Section 2)', 'Safety of Nuclear Installations - Methods, Analysis, Results (Section 3)', 'Front End and Back End of the Fuel Cycle, Radioactive Waste, Storage (Section 4)', 'Front End of the Fuel Cycle, Fuel Elements and Core Components (Section 5)', 'Operation of Nuclear Installations (Section 6)', 'Decommissioning of Nuclear Installations (Section 7)', 'Fusion Technology (Section 8)', 'Energy Industry and Economics (Section 10)', 'Radiation Protection (Section 11)', 'New Build and Innovations (Session New Build and Innovations, Section 12)', and 'Education, Expert Knowledge, Know-how-Transfer (Section 13)' have been covered in atw issues 10, 11 and 12 (2010). (orig.)

Structural, vibrational and nuclear magnetic resonance investigations of 4-bromoisoquinoline by experimental and theoretical DFT methods.

Science.gov (United States)

Arjunan, V; Thillai Govindaraja, S; Jayapraksh, A; Mohan, S

2013-04-15

Quantum chemical calculations of energy, structural parameters and vibrational wavenumbers of 4-bromoisoquinoline (4BIQ) were carried out by using B3LYP method using 6-311++G(**), cc-pVTZ and LANL2DZ basis sets. The optimised geometrical parameters obtained by DFT calculations are in good agreement with electron diffraction data. Interpretations of the experimental FTIR and FT-Raman spectra have been reported with the aid of the theoretical wavenumbers. The differences between the observed and scaled wavenumber values of most of the fundamentals are very small. The thermodynamic parameters have also been computed. Electronic properties of the molecule were discussed through the molecular electrostatic potential surface, HOMO-LUMO energy gap and NBO analysis. To provide precise assignments of (1)H and (13)CNMR spectra, isotropic shielding and chemical shifts were calculated with the Gauge-Invariant Atomic Orbital (GIAO) method. Copyright © 2013 Elsevier B.V. All rights reserved.

Spent Nuclear Fuel Cask and Storage Monitoring with {sup 4}He Scintillation Fast Neutron Detectors

Energy Technology Data Exchange (ETDEWEB)

Chung, Hee jun; Kelley, Ryan P; Jordan, Kelly A [Univ. of Florida, Florida (United States); Lee, Wanno [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Chung, Yong Hyun [Yonsei Univ., Wonju (Korea, Republic of)

2014-10-15

and terrorism. This study conducted a review and conceptual design of a new system for the monitoring of spent nuclear fuel pool and cask storage. Previous experimental results using {sup 4}He scintillator detectors have demonstrated the potential for these new detectors to be implemented in a spent fuel monitoring role. Their ability to preserve neutron energy information, while at the same time reject interfering gamma radiation, provides a new method of signal analysis. By applying energy cuts as proposed above, the spent fuel's fission signal can be isolated, and an algorithm for assembly identification developed.

TNF induction of EL4 hyposensitivity to lysis by recombinant (soluble) and membrane-associated TNFs: TNF binding, internalization, and degradation.

Science.gov (United States)

Fishman, M; Costlow, M

1994-04-01

EL4 mouse thymoma cells sensitive to TNF-mediated lysis only in the presence of cycloheximide (S-EL4) or in the presence or absence of cycloheximide (N-EL4) were used in these experiments. Murine tumor cell line (S-EL4) sensitivity to TNF cytotoxicity is augmented when cycloheximide is added together with TNF or when cycloheximide is added 1 hr before or after TNF. No enhanced sensitivity is observed when target cells are incubated with cycloheximide 2-4 hr before or after the addition of TNF. In the absence of cycloheximide, S-EL4 cells preexposed to murine TNF are less susceptible to lysis by TNF and TNF receptor-conjugated TNF but are lysed by integral membrane TNF. TNF-induced hyposensitivity is partially reversed by actinomycin D or by culturing the preexposed cells for 4 hr prior to TNF lytic assay. TNF preincubation of N- and S-EL4 cells results in an immediate decrease in 125I-TNF binding due to TNF receptor occupancy. Recovery of TNF-R occupancy and TNF internalization were subsequently noted.

Growth of the parvovirus minute virus of mice MVMp3 in EL4 lymphocytes is restricted after cell entry and before viral DNA amplification: cell-specific differences in virus uncoating in vitro.

Science.gov (United States)

Previsani, N; Fontana, S; Hirt, B; Beard, P

1997-10-01

Two murine parvoviruses with genomic sequences differing only in 33 nucleotides (8 amino acids) in the region coding for the capsid proteins show different host cell specificities: MVMi grows in EL4 T lymphocytes and MVMp3 grows in A9 fibroblasts. In this study we compared the courses of infections with these two viruses in EL4 cells in order to investigate at which step(s) the infection process of MVMp3 is interrupted. The two viruses bound equally well to EL4 cells, and similar amounts of MVMi and MVMp3 input virion DNA appeared in the nuclear fractions of EL4 cells 1 h after infection. However, double-stranded replicative-form (RF) DNA of the two viruses appeared at different times, at 10 h postinfection with MVMi and at 24 h postinfection with MVMp3. The amount of MVMp3 RF DNA detected at 24 h was very small because it was produced only in a tiny subset of the population of EL4 cells that proved to be permissive for MVMp3. Replication of double-stranded viral DNA in EL4 cells was measured after transfection of purified RF DNA, cloned viral DNA, and cloned viral DNA with a mutation preventing synthesis of the capsid proteins. In each of these cases, DNA replication was comparable for MVMi and MVMp3. Production of virus particles also appeared to be similar after transfection of the two types of RF DNA into EL4 cells. Conversion of incoming 32P-labeled single-stranded MVM DNA to 32P-labeled double-stranded RF DNA was detected only after RF DNA amplification, indicating that few molecules serve as templates for viral DNA amplification. We showed that extracts of EL4 cells contain a factor which can destabilize MVMi virions but not MVMp3 by testing the sensitivity of viral DNA to DNase and by CsCl gradient analyses of viral particles. We therefore conclude that the MVMp3 life cycle is arrested after the transport of virions to the nucleus and prior to the replication of RF DNA, most likely at the stage of viral decapsidation.

Doctoral education in the nuclear sector; La formacion de doctores en el sector nuclear

Energy Technology Data Exchange (ETDEWEB)

Minguez, E.

2013-03-01

Doctoral aducation is a major priority for European universities. In the context of the Bologna Process the importance of doctoral education as the third cycle of higher education and the first stage of a young researchers career, and thus in linking the European Higher Education and Research Areas, was first highlighted in the 2003 Berlin Report. The core component of doctoral training is the advancement of knowledge through original research. considering the need for structured doctoral programs and the need for transparent supervision and assessment, we note that the normal workload of the third cycle in most countries would correspond 3-4 years full time. This is spirit of the new Spanish Doctoral Law. Then, universities should ensure that their doctoral programmes promote interdisciplinary training and the development of transferable skills, thus meeting the needs of the wider employment market. We need to achieve and overall increase in the numbers of doctoral candidates taking up research careers as early stage researchers and also increase the employability as a normal way as it is the case of other advance countries. In Spain, universities with doctoral nuclear programmes and the CIEMAT, with the sponsorship of the nuclear sector, a doctoral school in nuclear science and engineering should be created to enhance the research careers of Young students for the future of nuclear activities in Spain. (Author)

International nuclear fuel cycle fact book. Revision 4

Energy Technology Data Exchange (ETDEWEB)

Harmon, K.M.; Lakey, L.T.; Leigh, I.W.

1984-03-01

This Fact Book has been compiled in an effort to provide (1) an overview of worldwide nuclear power and fuel cycle programs and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries - a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids - international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate.

International nuclear fuel cycle fact book. Revision 4

International Nuclear Information System (INIS)

Harmon, K.M.; Lakey, L.T.; Leigh, I.W.

1984-03-01

This Fact Book has been compiled in an effort to provide (1) an overview of worldwide nuclear power and fuel cycle programs and (2) current data concerning fuel cycle and waste management facilities, R and D programs, and key personnel in countries other than the United States. Additional information on each country's program is available in the International Source Book: Nuclear Fuel Cycle Research and Development, PNL-2478, Rev. 2. The Fact Book is organized as follows: (1) Overview section - summary tables which indicate national involvement in nuclear reactor, fuel cycle, and waste management development activities; (2) national summaries - a section for each country which summarizes nuclear policy, describes organizational relationships and provides addresses, names of key personnel, and facilities information; (3) international agencies - a section for each of the international agencies which has significant fuel cycle involvement; (4) energy supply and demand - summary tables, including nuclear power projections; (5) fuel cycle - summary tables; and (6) travel aids - international dialing instructions, international standard time chart, passport and visa requirements, and currency exchange rate

Numerical and experimental study of hydraulic dashpot used in the shut-off rod drive mechanism of a nuclear reactor

Energy Technology Data Exchange (ETDEWEB)

Singh, Narendra K., E-mail: nksingh_chikki@yahoo.com [Division of Remote Handling and Robotics, Bhabha Atomic Research Centre, Mumbai 400085 (India); Badodkar, Deepak N. [Division of Remote Handling and Robotics, Bhabha Atomic Research Centre, Mumbai 400085 (India); Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094 (India); Singh, Manjit [Division of Remote Handling and Robotics, Bhabha Atomic Research Centre, Mumbai 400085 (India)

2014-07-01

Highlights: • Hydraulic dashpot performance is studied numerically as well as experimentally. • Instantaneous pressure built-up in the dashpot is mainly contributing for damping of freely falling shut-off rod at the end of its travel. • At elevated temperature, dashpot pressure does not reduce in proportion to the reduction in viscosity. • ‘C’ grove in the dashpot shaft flattens the pressure peak and shifts it toward the end of operation. - Abstract: Hydraulic dashpot design for shut-off rod drive mechanism application in a nuclear reactor has been analyzed both numerically and experimentally in this paper. Finite element commercial code COMSOL Multiphysics 4.3 has been used for numerical analysis. Experimental validation has been done at two different cases. Experimental test set-ups and hydraulic dashpot constructions have been described in detail. Various combinations of dashpot oil viscosity and clearance thickness have been analyzed. Important experimental results are also presented and discussed. Pressure distributions in the dashpot chambers obtained from COMSOL are given for both the set-ups. Numerical and experimental results are compared. Dashpot designs have been qualified after detailed analysis and testing on full-scale test stations simulating actual reactor conditions (except radiation)

Numerical and experimental study of hydraulic dashpot used in the shut-off rod drive mechanism of a nuclear reactor

International Nuclear Information System (INIS)

Singh, Narendra K.; Badodkar, Deepak N.; Singh, Manjit

2014-01-01

Highlights: • Hydraulic dashpot performance is studied numerically as well as experimentally. • Instantaneous pressure built-up in the dashpot is mainly contributing for damping of freely falling shut-off rod at the end of its travel. • At elevated temperature, dashpot pressure does not reduce in proportion to the reduction in viscosity. • ‘C’ grove in the dashpot shaft flattens the pressure peak and shifts it toward the end of operation. - Abstract: Hydraulic dashpot design for shut-off rod drive mechanism application in a nuclear reactor has been analyzed both numerically and experimentally in this paper. Finite element commercial code COMSOL Multiphysics 4.3 has been used for numerical analysis. Experimental validation has been done at two different cases. Experimental test set-ups and hydraulic dashpot constructions have been described in detail. Various combinations of dashpot oil viscosity and clearance thickness have been analyzed. Important experimental results are also presented and discussed. Pressure distributions in the dashpot chambers obtained from COMSOL are given for both the set-ups. Numerical and experimental results are compared. Dashpot designs have been qualified after detailed analysis and testing on full-scale test stations simulating actual reactor conditions (except radiation)

Excitation functions of alpha particles induced nuclear reactions on natural titanium in the energy range of 10.4–50.2 MeV

International Nuclear Information System (INIS)

Usman, Ahmed Rufai; Khandaker, Mayeen Uddin; Haba, Hiromitsu; Otuka, Naohiko; Murakami, Masashi

2017-01-01

Highlights: • Detailed presentation of new results on experimental cross-sections of "n"a"tTi(α,x) processes. • Calculations of thick target yields for scandium and other radionuclides via the "n"a"tTi(α,x) production route. • Comparison with TENDL-2015 library. • Detailed review of previous experimental data. - Abstract: We studied the excitation functions of residual radionuclide productions from α particles bombardment on natural titanium in the energy range of 10.4–50.2 MeV. A well-established stacked-foil activation technique combined with HPGe γ-ray spectrometry was used to measure the excitation functions for the "5"1","4"9","4"8Cr, "4"8V, "4"3K, and "4"3","4"4"m","4"4"g","4"6"g"+"m","4"7","4"8Sc radionuclides. The thick target yields for all assessed radionuclides were also calculated. The obtained experimental data were compared with the earlier experimental ones and also with the evaluated data in the TENDL-2015 library. A reasonable agreement was found between this work and some of the previous ones, while a partial agreement was found with the evaluated data. The present results would further enrich the experimental database and facilitate the understanding of existing discrepancies among the previous measurements. The results would also help to enhance the prediction capability of the nuclear reaction model codes.

Drawing the nuclear landscape: 50 years of the Karlsruhe Nuklidkarte; Trazando el paisaje nuclear 50 anos de historia de la Karlsruher Nuklidkarte

Energy Technology Data Exchange (ETDEWEB)

Garcia Borge, M. J.; Normand, C.

2010-07-01

The map has been Nuklidkarte Karlsruhe nuclei since 1958 the work of thousands of physicists and hundreds of thousands experimental results produced in institutes research worldwide. With excellence as rule, has become over the years a reference the field of nuclear information. (Author) 19 refs.

Health and Safety Considerations Associated with Sodium-Cooled Experimental Nuclear Fuel Dismantlement

Energy Technology Data Exchange (ETDEWEB)

Carvo, Alan E. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-04-01

Between the mid-1970s and the mid-1980s Sandia National Laboratory constructed eleven experimental assemblies to simulate debris beds formed in a sodium-cooled fast breeder reactor. All but one of the assemblies were irradiated. The experimental assemblies were transferred to the Idaho National Laboratory (INL) in 2007 and 2008 for storage, dismantlement, recovery of the uranium for reuse in the nuclear fuel cycle, and disposal of unneeded materials. This paper addresses the effort to dismantle the assemblies down to the primary containment vessel and repackage them for temporary storage until such time as equipment necessary for sodium separation is in place.

sup 4 sup 4 Ti atom counting for nuclear astrophysics

CERN Document Server

Hui, S K; Berkovits, D; Boaretto, E; Ghelberg, S; Hass, M; Hershkowitz, A; Navon, E

2000-01-01

The nuclide sup 4 sup 4 Ti (T sub 1 sub / sub 2 =59.2 yr) has recently become an important asset to nuclear astrophysics through the measurement of its cosmic radioactivity, yielding significant information on fresh sup 4 sup 4 Ti nucleosynthesis in supernovae. We propose to use AMS to determine the production rate of sup 4 sup 4 Ti by the main channel believed to be responsible for sup 4 sup 4 Ti astrophysical production, namely sup 4 sup 0 Ca(alpha,gamma). A preliminary experiment conducted at the Koffler 14UD Pelletron accelerator demonstrates a sensitivity of 1x10 sup - sup 1 sup 4 for the sup 4 sup 4 Ti/Ti ratio. The AMS detection was performed using sup 4 sup 4 Ti sup - ions sputtered from a TiO sub 2 sample, reducing considerably the sup 4 sup 4 Ca isobaric interference. The present limit corresponds effectively to sup 4 sup 4 Ti production with resonance strength in the range 10-100 meV for a one-day sup 4 sup 0 Ca(alpha,gamma) activation. Several such resonances are known to be responsible for sup 4 ...

Las movilizaciones del 4 de febrero y el 6 de marzo de 2008. Una lectura de las representaciones sociales en el discurso de la prensa nacional

Directory of Open Access Journals (Sweden)

Carolina Jaramillo Correa

2010-01-01

Full Text Available Las convocatorias y la respuesta a las marchas del 4 de febrero y el 6 de marzo de 2008 se han constituido como uno de los mayores impactos en términos de movilización ciudadana en Colombia. Los medios masivos de comunicación fueron actores decisivos para la divulgación de las marchas, y de persuasión para que los ciudadanos se sumaran o no a éstas. El equipo de investigación del proyecto Representaciones de las movilizaciones sociales por la paz en la prensa colombiana: 4 de febrero y 6 de marzo de 2008 recopiló las noticias sobre las marchas publicadas en tres diarios impresos de circulación nacional: el diario El Tiempo (el mayor periódico nacional, el diario El Colombiano (que representa la región del país con el índice más alto de movilizaciones sociales y el semanario Voz (que representa los sectores políticos de izquierda y pertenece al partido comunista. Este artículo presenta la clasificación y categorización de información desde la perspectiva del análisis del discurso (ad y una aproximación a los resultados de la categorización cualitativa de la información.

Experimental study of the pile EL3; Etude experimentale de la pile EL3

Energy Technology Data Exchange (ETDEWEB)

NONE

1958-07-01

The results of two months' experiments, carried out at low power following the first divergence (4. July 1957) are presented. These experiments dealt with the following points: comparison of experimental and calculated values of the critical size; effects due to the introduction of absorbing materials into the principal experimental facilities, flux distribution measurements especially in these facilities, calibration of safety, control and compensating rods, determination of the average life of the neutrons. (author) [French] On expose les resultats relatifs a deux mois d'experiences effectuees a basse puissance a la suite de la premiere divergence (4 juillet 1957). Ces experiences ont porte sur les points suivants: comparaison des tailles critiques experimentales et calculees, effets dus a l'introduction de corps absorbants dans les principaux dispositifs experimentaux, mesures des distributions de flux particulierement dans ces dispositifs, etalonnage des barres de securite, de reglage et de compensation, determination de la vie moyenne des neutrons. (auteur)

A systematic study of distribution characters of infiltration parameters in an experimental basin by nuclear methods

International Nuclear Information System (INIS)

Gu Weizu; Lu Jieju; Lu Mingjiang; Chen Tingyang

1988-01-01

A case study of spatial variability of Philip's infiltration parameters was carried out in a small experimental catchment with an area of 0.8 ha by nuclear monitoring methods. Relationships between sorptivity S, parameter A and the average initial soil water content within 0.5 m depth of soil profiles over the catchment have been plotted. A watershed infiltration parameter distribution curve is set up and fitted approximately by f/F=1-(1-S/S M ) n . The parameters of composite infiltration response related to whole catchment are suggested. The author has studied it on an experimental basin by combined method of nuclear technology and micro-geomorphic analysis. The results are satisfactory. (author). 6 refs, 11 figs, 2 tabs

[Regulatory T cells inhibit proliferation of mouse lymphoma cell line EL4 in vitro].

Science.gov (United States)

Zhang, Chen; Kong, Yan; Guo, Jun; Ying, Zhi-Tao; Yuan, Zhi-Hong; Zhang, Yun-Tao; Zheng, Wen; Song, Yu-Qin; Li, Ping-Ping; Zhu, Jun

2010-10-01

This study was aimed to investigate the effect of regulatory T (Treg) cells on the T cell lymphoma EL4 cells and its mechanism in vitro. C57BL/6 mouse Treg cells were isolated by magnetic cell sorting (MACS). The purity of Treg cells and their expression of Foxp3 were identified by flow cytometry (FCM) and PT-PCR respectively. The suppression of Treg cells on EL4 cells was detected by 3H-TdR method. At the same time, enzyme-linked immunosorbent assay (ELISA) was used to detect the secretion of cytokine TGF-β1 and IL-10. The results showed that CD4+CD25+ T cells could be successfully isolated by MACS with the purity reaching 94.52% and the expression of Foxp3 reaching 84.72%. After sorting, the expression of Foxp3 mRNA could be detected by RT-PCR. 3H-TdR assay confirmed that regulatory T cells could suppress the proliferation of EL4 cells with or without antigen presenting cells (APC) or dendritic cells (DC), APC or DC might effectively enhance the suppression. In addition, DC alone also suppressed the proliferation. TGF-β1 and IL-10 could be detected in the supernatant by ELISA. It is concluded that the Treg cells can obviously suppress the proliferation of T cell lymphoma cells in vitro, APC or DC can enhance this suppressive effect, while the DC alone also can suppress the proliferation of EL4 cells, the TGF-β1 and IL-10 cytokine pathway may be one of the mechanisms of suppression.

Nuclear data newsletter. No. 4

International Nuclear Information System (INIS)

1982-02-01

This issue announces the INDC(SEC)-78 report. This document lists nuclear reaction, mostly neutron reactions but also charged-particle reactions or half-lives, for which existing data have insufficient accuracy as to meet the requirements in the physics of nuclear reactors, safeguards and nuclear fusion. It also lists the new nuclear data libraries recently received by the Nuclear Data Section of the IAEA, as well as a selection of new relevant documents

Nuclear data newsletter. No. 4

Energy Technology Data Exchange (ETDEWEB)

NONE

1982-02-01

This issue announces the INDC(SEC)-78 report. This document lists nuclear reaction, mostly neutron reactions but also charged-particle reactions or half-lives, for which existing data have insufficient accuracy as to meet the requirements in the physics of nuclear reactors, safeguards and nuclear fusion. It also lists the new nuclear data libraries recently received by the Nuclear Data Section of the IAEA, as well as a selection of new relevant documents.

Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells.

Science.gov (United States)

Han, S H; Yea, S S; Jeon, Y J; Yang, K H; Kaminski, N E

1998-12-01

Transforming growth factor beta1 (TGF-beta1) has been previously shown to modulate interleukin 2 (IL-2) secretion by activated T-cells. In the present studies, we determined that TGF-beta1 induced IL-2 mRNA expression in the murine T-cell line EL4, in the absence of other stimuli. IL-2 mRNA expression was significantly induced by TGF-beta1 (0.1-1 ng/ml) over a relatively narrow concentration range, which led to the induction of IL-2 secretion. Under identical condition, we examined the effect of TGF-beta1 on the activity of nuclear factor AT (NF-AT), nuclear factor kappaB (NF-kappaB), activator protein-1 (AP-1) and octamer, all of which contribute to the regulation of IL-2 gene expression. Electrophoretic mobility shift assays showed that TGF-beta1 markedly increased NF-AT, NF-kappaB and AP-1 binding to their respective cognate DNA binding sites, whereas octamer binding remained constant, as compared with untreated cells. Employing a reporter gene expression system with p(NF-kappaB)3-CAT, p(NF-AT)3-CAT and p(AP-1)3-CAT, TGF-beta1 treatment of transfected EL4 cells induced a dose-related increase in chloramphenicol acetyltransferase activity that correlated well with the DNA binding profile found in the electrophoretic mobility shift assay studies. These results show that TGF-beta1, in the absence of any additional stimuli, up-regulates the activity of key transcription factors involved in IL-2 gene expression, including NF-AT, NF-kappaB and AP-1, to help promote IL-2 mRNA expression by EL4 cells.

Nuclear Transparency with the gamma + n -> pi- + p Process in 4He

International Nuclear Information System (INIS)

Dipangkar Dutta; Feng Xiong; Lingyan Zhu; John Arrington; Todd Averett; Elizabeth Beise; John Calarco; Ting Chang; Jian-Ping Chen; Eugene Chudakov; Marius Coman; Benjamin Clasie; Christopher Crawford; Sonja Dieterich; Frank Dohrmann; Kevin Fissum; Salvatore Frullani; Haiyan Gao; Ronald Gilman; Charles Glashausser; Javier Gomez; Kawtar Hafidi; Jens-Ole Hansen; Douglas Higinbotham; Holt, R.J.; Cornelis De Jager; Xiaochao Zheng; Jiang, X.; Edward Kinney; Kevin Kramer; Gerfried Kumbartzki; John LeRose; Nilanga Liyanage; David Mack; Pete Markowitz; Kathy McCormick; Zein-Eddine Meziani; Robert Michaels; Mitchell, J.; Sirish Nanda; David Potterveld; Ronald Ransome; Paul Reimer; Bodo Reitz; Arunava Saha; Elaine Schulte; Charles Seely; Simon Sirca; Steffen Strauch; Vincent Sulkosky; Branislav Vlahovic; Lawrence Weinstein; Krishni Wijesooriya; Claude Williamson; Bogdan Wojtsekhowski; Hong XIANG; Wang Xu; Zeng, J.

2003-01-01

We have measured the nuclear transparency of the fundamental process γ n → π - p in 4 He. These measurements were performed at Jefferson Lab in the photon energy range of 1.6 to 4.5 GeV and at θ cm π = 70 o and 90 o . These measurements are the first of their kind in the study of nuclear transparency in photoreactions. They also provide a benchmark test of Glauber calculations based on traditional models of nuclear physics. The transparency results suggest deviations from the traditional nuclear physics picture. The momentum transfer dependence of the measured nuclear transparency is consistent with Glauber calculations which include the quantum chromodynamics phenomenon of color transparency

Lysosomal processing of sialoglycoconjugates in a wheat germ agglutinin resistant variant of EL4 murine leukemia cells

International Nuclear Information System (INIS)

Devino, N.L.

1989-01-01

Metabolic studies were undertaken in EL4 murine leukemia in WB6, a wheat germ agglutinin-resistant variant of EL4, in order to identify any differences in lysosomal processing of sialoglyco-conjugates. Five lysosomal acid hydrolases, acetylesterase, acid phosphatase, β-galactosidase, α-mannosidase, and neuraminidase, were studied using fluorescent 4-methylumbelliferyl substrates. No significant differences were found in the total activity of any of these enzymes in EL4 and WB6. Cells were incubated in the presence of N-acetylmannosamine, the metabolic precursor of sialic acid (N-acetylneuraminic acid). Free sialic acid accumulated in the lysosomes of WB6 but not of EL4. The accumulation of lysosomal free sialic acid in WB6 showed a dependence on the concentration of N-acetylmannosamine in the growth medium. Metabolic labelling with [6- 3 H]-N-acetylmannosamine showed that WB6 accumulated lysosomal free sialic acid even at very low concentrations of N-acetylmannosamine. The two cell lines differed in their distribution of radiolabelled neutral sugars, free sialic acid, and sialoglycoproteins. The velocity of 3 H-sialic acid release was 3.7-fold lower in WB6 than in EL4, suggesting that WB6 has a defect in lysosomal sialic acid transport. The metabolic consequences of this defect are examined, in light of other biochemical and immunological data on these cells

Modeling a nuclear reactor for experimental purposes

International Nuclear Information System (INIS)

Berta, V.T.

1980-01-01

The Loss-of-Fluid Test (LOFT) Facility is a scale model of a commercial PWR and is as fully functional and operational as the generic commercial counterpart. LOFT was designed and built for experimental purposes as part of the overall NRC reactor safety research program. The purpose of LOFT is to assess the capability of reactor safety systems to perform their intended functions during occurrences of off-normal conditions in a commercial nuclear reactor. Off-normal conditions arising from large and small break loss-of-coolant accidents (LOCA), operational transients, and anticipated transients without scram (ATWS) were to be investigated. This paper describes the LOFT model of the generic PWR and summarizes the experiments that have been conducted in the context of the significant findings involving the complex transient thermal-hydraulics and the consequent effects on the commercial reactor analytical licensing techniques. Through these techniques the validity of the LOFT model as a scaled counterpart of the generic PWR is shown

RasGRP1 confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells.

Science.gov (United States)

Han, Shujie; Knoepp, Stewart M; Hallman, Mark A; Meier, Kathryn E

2007-01-01

The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA). In sensitive EL4 cells, PMA causes robust Erk mitogen-activated protein kinase activation that results in growth arrest. In resistant cells, PMA induces minimal Erk activation, without growth arrest. PMA stimulates IL-2 production in sensitive, but not resistant, cells. The role of RasGRP1, a PMA-activated guanine nucleotide exchange factor for Ras, in EL4 phenotype was examined. Endogenous RasGRP1 protein is expressed at much higher levels in sensitive than in resistant cells. PMA-induced Ras activation is observed in sensitive cells but not in resistant cells lacking Ras-GRP1. PMA induces down-regulation of RasGRP1 protein in sensitive cells but increases RasGRP1 in resistant cells. Transfection of RasGRP1 into resistant cells enhances PMA-induced Erk activation. In the reverse experiment, introduction of small interfering RNA (siRNA) for RasGRP1 suppresses PMA-induced Ras and Erk activations in sensitive cells. Sensitive cells incubated with siRNA for RasGRP1 exhibit the PMA-resistant phenotype, in that they are able to proliferate in the presence of PMA and do not secrete IL-2 when stimulated with PMA. These studies indicate that the PMA-sensitive phenotype, as previously defined for the EL4 cell line, is conferred by endogenous expression of RasGRP1 protein.

Viabilidade económica da implementação de um reactor nuclear para a produção de energia eléctrica em Portugal

OpenAIRE

Pedro, Miguel António de Morais

2012-01-01

O presente trabalho tem como objectivo avaliar economicamente e determinar a viabilidade da implementação de um reactor nuclear para produção de energia eléctrica. Faz-se uma abordagem a aspectos da energia nuclear no mundo e em particular a energia nuclear na união europeia, faz-se uma análise sobre a estrutura do sector nuclear em Espanha e o futuro da energia no mundo. É realizada uma análise sobre a energia nuclear em Portugal, são abordados aspectos como o planeamento energético, a local...

Experimental study of nuclear models. I. Decay schemes and nuclear reactions. II. Muonic x-ray studies. Progress report, October 1, 1974--September 30, 1975

International Nuclear Information System (INIS)

Sheline, R.K.

1975-01-01

Progress on the research on our AT-(40-1)-2434 Contract is summarized for the twelve month contract year beginning October 1, 1974, and ending September 30, 1975. The main emphasis of our research continues to be an experimental study of nuclear models. Some change of emphasis is occurring. In the past, the emphasis has been overwhelmingly nuclear reaction spectroscopy and comparison with theoretical models. This year an increasing percentage of the emphasis (perhaps 25 percent) is on the study of nuclear structure from the view point of muonic x-ray spectroscopy. A list of publications is included. (U.S.)

New nuclear projects in the world. Sustainable Nuclear Energy; Nuevos proyectos nucleares en el mundo. energia nuclear sostenible

Energy Technology Data Exchange (ETDEWEB)

Leon, P. T.

2011-07-01

Nuclear power has experienced a major boom in the last few years, primarily because it is a non-CO{sub 2} emitting energy source, it can be produced at competitive costs and it can boost a country's security of supply. there are still two issues to be addressed in relation to the currently used technologies: the degree to which the energy content of nuclear fuel is used, and wastes. A solution to both these aspects would ut nuclear power in the category of sustainable energy. The article provides details on current nuclear plans in the wold, the impact of the Fukushima accident on different countries nuclear plans and the European initiatives for sustainable nuclear energy development. (Author)

Equipment to evaluate in experimental form the thermal conductivity of the construction materials; Equipo para evaluar en forma experimental el coeficiente de conductividad termica de los materiales de construccion

Energy Technology Data Exchange (ETDEWEB)

Lopez C, Raymundo; Morales G, Juan R.; Diaz C, Alen; Lizardi R, Arturo [Universidad Autonoma Metropolitana-Azcapotzalco, Mexico, D. F. (Mexico); Vaca M, Mabel [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

2001-04-01

An equipment meant to obtain the thermal conductivity coefficient was designed, constructed and evaluated. Convection losses in the experimental device were reduced by means of a vacuum chamber that wraps it. Conduction losses were minimized with the proper insulation. The tested materials are the most frequently used in the construction of buildings in Mexico, such as concrete, burnt brick, adobe and gypsum. Results observed are comparable to those reported in the literature. The essays done using the vacuum chamber produced values of thermal conductivity coefficient 3% lower than those obtained without using it. [Spanish] Se diseno, construyo y evaluo un equipo, con el cual se obtiene el coeficiente de conductividad termica en diversos materiales. En este se reducen las perdidas por conveccion, colocando una camara de vacio alrededor del conjunto de prueba. Las perdidas por conduccion se minimizan con un aislamiento adecuado. Los materiales evaluados son los que mas se utilizan en la construccion en Mexico, a saber, el concreto, el ladrillo cocido, el adobe y el yeso. Los valores obtenidos, sin considerar las perdidas por conveccion, se comparan con los de la literatura. Los ensayos utilizando la camara de vacio proporcionan valores del coeficiente de conductividad termica menores en 3% a los obtenidos sin dicha camara.

Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV

Energy Technology Data Exchange (ETDEWEB)

Fukuchi, Mikoto; Wanotayan, Rujira; Liu, Sicheng; Imamichi, Shoji; Sharma, Mukesh Kumar; Matsumoto, Yoshihisa, E-mail: yoshim@nr.titech.ac.jp

2015-06-12

XRCC4 and DNA Ligase IV (LIG4) cooperate to join two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). However, it is not fully understood how these proteins are localized to the nucleus. Here we created XRCC4{sup K271R} mutant, as Lys271 lies within the putative nuclear localization signal (NLS), and XRCC4{sup K210R} mutant, as Lys210 was reported to undergo SUMOylation, implicated in the nuclear localization of XRCC4. Wild-type and mutated XRCC4 with EGFP tag were introduced into HeLa cell, in which endogenous XRCC4 had been knocked down using siRNA directed to 3′-untranslated region, and tested for the nuclear localization function by fluorescence microscopy. XRCC4{sup K271R} was defective in the nuclear localization of itself and LIG4, whereas XRCC4{sup K210R} was competent for the nuclear localization with LIG4. To examine DSB repair function, wild-type and mutated XRCC4 were introduced into XRCC4-deficient M10. M10-XRCC4{sup K271R}, but not M10-XRCC4{sup K210R}, showed significantly reduced surviving fraction after 2 Gy γ-ray irradiation as compared to M10-XRCC4{sup WT}. The number of γ-H2AX foci remaining 2 h after 2 Gy γ-ray irradiation was significantly greater in M10-XRCC4{sup K271R} than in M10-XRCC4{sup WT}, whereas it was only marginally increased in M10-XRCC4{sup K210R} as compared to M10-XRCC4{sup WT}. The present results collectively indicated that Lys271, but not Lys210, of XRCC4 is required for the nuclear localization of XRCC4 and LIG4 and that the nuclear localizing ability is essential for DSB repair function of XRCC4. - Highlights: • XRCC4{sup K271R} is defective in the nuclear localization of itself and LIG4. • XRCC4{sup K210R} is competent for the nuclear localization of itself and LIG4. • XRCC4{sup K271R} is deficient in DSB repair function. • XRCC4{sup K210R} is mostly normal in DSB repair function.

El aprendizaje mixto en la preparaci??n de la prueba de acceso a la universidad en lengua inglesa: aportaciones de un estudio experimental

OpenAIRE

Mart??n Monje, Elena

2013-01-01

El an??lisis de los datos de la prueba de acceso a la universidad en lengua inglesa de los ??ltimos a??os evidencia unos bajos resultados de este idioma frente a los de otras materias, por lo que resulta propicia una intervenci??n educativa que explore las causas y ofrezca soluciones en este ??mbito. Este trabajo muestra los resultados de un estudio experimental en el que se introduce una nueva metodolog??a de aprendizaje mixto, combinando ense??anza presencial con el apoyo de un entorno virt...

Pretreatment of low dose radiation reduces radiation-induced apoptosis in mouse lymphoma (EL4) cells.

Science.gov (United States)

Kim, J H; Hyun, S J; Yoon, M Y; Ji, Y H; Cho, C K; Yoo, S Y

1997-06-01

Induction of an adaptive response to ionizing radiation in mouse lymphoma (EL4) cells was studied by using cell survival fraction and apoptotic nucleosomal DNA fragmentation as biological end points. Cells in early log phase were pre-exposed to low dose of gamma-rays (0.01 Gy) 4 or 20 hrs prior to high dose gamma-ray (4, 8 and 12 Gy for cell survival fraction analysis; 8 Gy for DNA fragmentation analysis) irradiation. Then cell survival fractions and the extent of DNA fragmentation were measured. Significant adaptive response, increase in cell survival fraction and decrease in the extent of DNA fragmentation were induced when low and high dose gamma-ray irradiation time interval was 4 hr. Addition of protein or RNA synthesis inhibitor, cycloheximide or 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRFB), respectively during adaptation period, the period from low dose gamma-ray irradiation to high dose gamma-ray irradiation, was able to inhibit the induction of adaptive response, which is the reduction of the extent DNA fragmentation in irradiated EL4 cells. These data suggest that the induction of adaptive response to ionizing radiation in EL4 cells required both protein and RNA synthesis.

Specific anti-EL4-lymphoma immunity in mice cured 2 years earlier with doxorubicin and interleukin-2.

Science.gov (United States)

Ehrke, M J; Verstovsek, S; Zaleskis, G; Ho, R L; Ujházy, P; Maccubbin, D L; Mihich, E

1996-05-01

This laboratory has reported the conditions for an effective, non-toxic, chemoimmunotherapy utilizing doxorubicin in combination with prolonged administration of interleukin-2 and the identification of the critical role of activated CD8+ T cells in the therapeutic effect. Mice (C57BL/6) cured in those studies have been followed for the remainder of their life spans. These mice, approximately 2 months of age when initially inoculated with syngeneic EL4 lymphoma, survived for more than 2 years, the normal life span of C57BL/6 mice. Mice 4 months old reinoculated with the EL4 cells all survived. At about 1 year of age mice were sacrificed and the ability of their thymocytes and splenocytes to develop specific CD8+ anti-EL4 activity was as high as it had been at the time of tumor rejection. At about 2 years of age EL4 was reimplanted into mice; all of them survived. These surviving mice, at 2 years 2 months of age, as well as a group of 2-year-old mice not rechallenged, were killed and functional antitumor activity and phenotype characteristics of various lymphocyte populations were determined in comparison to those of young and age-matched control mice. The phenotyping of the lymphocytes from the cured mice indicated very notable differences in subset distribution and increased CD44 expression. Functionally they developed high levels of anti-EL4 activity, which was ablated by combined treatment with monoclonal antibodies against CD8 and CD44, indicating the role of memory cells. Consistent with cells from aged mice, these same cell populations had a very reduced allogeneic responsiveness. It appears that cured mice have developed an immune memory specific for EL4.

Design of the Small Rods Forming the Fuel Element of the First Charge of the EL4 Reactor. Cladding Problems; Etude des crayons constituant l'element combustible du premier jeu d'EL4 - probleme de la gaine; Problema pokrytiya nebol'shikh steeknej, obrazushchikh toplivnyj ehlement pervoj zagruzki reaktora EL.4; Estudio de las barras que constituyen los elementos combustibles de la primera carga del reactor EL4 - el problema de las vainas

Energy Technology Data Exchange (ETDEWEB)

Bailly, H.; Ringot, C.; Weisz, M. [Centre d' Etudes Nucleaires de Saclay (France)

1963-11-15

The fuel element for the first charge of EL4 makes use of stainless steel cans. The grade of steel chosen and the can thickness depend on the corrosion resistance and mechanical strength required. The operating stresses and temperatures are such that fabrication of a can lasting throughout the life of the fuel element calls for a highly resistant grade of steel, of thickness greater than 0.5 mm. When the can bears on the fuel as a result of creep, deformation in diametrical clearance may lead to ovalization and folding, while deformation in longitudinal clearance may cause buckling of the can. Numerous tests have been carried out on cans of thickness 0.3 and 0.4 mm to determine type of deformation as a function of clearance. To be certain of avoiding ovalization with the thicknesses proposed and to keep the internal temperature of the fuel as low as possible, the clearance must be reduced to zero in fabrication. (author) [French] L'element combustible du premier jeu EL4 utilise des gaines en acier inoxydable. Le choix de la nuance et de l'epaisseur de la gaine est lie a des considerations de tenue a la corrosion et de tenue mecanique. Les contraintes et les temperatures d'utilisation ne permettent pas de concevoir une gaine resistante pendant toute la vie de l'element combustible a moins d'utiliser une nuance tres resistante et d'epaisseur superieure a 0,5 mm. On admet que la gaine s'applique par fluage sur le combustible: la deformation dans les jeux diametraux peut conduire a la formation d'une ovalisation et d'un pli; la deformation dans les jeux longitudinaux peut conduire a des flambages de la gaine. De nombreux essais ont ete realises sur des gaines d'epaisseurs 0,3 et 0,4 mm pour connaitre le mode de deformation en fonction des jeux. Pour etre certain de ne jamais avoir d'ovalisation avec les epaisseurs envisagees, et pour avoir la temperature a coeur du combustible la plus basse possible, on est conduit a reduire a zero le jeu en fabrication. (author

La retención del conocimiento tácito de los expertos en el sector nuclear: una visión general

Directory of Open Access Journals (Sweden)

ÓSCAR RODRÍGUEZ RUIZ

2007-01-01

Full Text Available La industria nuclear ha realizado una significativa labor de investigación analítica en el área de reactores en los últimos cincuenta años. Buena parte del conocimiento obtenido tiene carácter tácito, por lo que existe el riesgo de que se pierda a medida que las organizaciones se reestructuren, las prioridades cambien y los trabajadores más experimentados se retiren. Este artículo pretende ofrecer una visión general de las distintas estrategias de retención del conocimiento experto en el sector de la energía atómica. Con esta finalidad realiza una revisión de diferentes iniciativas de difusión del conocimiento tácito desde una perspectiva socio-cognitiva.

Experimental nuclear physics

Science.gov (United States)

An earlier study of unusual electromagnetic decays in (sup 86)Zr was extended in order to make comparisons with its isotone (sup 84)Sr and with (sup 84)Zr. The K=14 (t(sub 1/2) = 70 ns) high-spin isomer in (sup 176)W was found to have a 13 percent branch directly to the K=O ground-state band, one of the strongest violations of K-selection rules known. A new program to search for a predicted region of oblate deformation involving neutron deficient isotopes in the Rn/Fr/Ra region was begun. In the area of nuclear astrophysics, as part of a study of the onset of the rp-Process, a set of measurements searching for possible new resonances for (sup 14)O+(alpha) and (sup 17)F+p reactions was completed and a coincidence experiment measuring the (sup 19)F ((sup 3)He,t) (sup 19)Ne(alpha) (sup 15)O and (sup 19)F ((sup 3)He,t) (sup 19)Ne(p) (sup 18)F reactions in order to determine the rates of the (sup 18)F(p,(alpha)) (sup 15)O and (sup 18)F(p,(gamma)) (sup 19)Ne reactions was begun. Experimental measurements of (beta)n(alpha) coincidences from the (sup 15)N(d,p) (sup 16)N((beta)- (nu)) (sup 16)O((alpha)) (sup 12)C reaction have also been completed and are currently being analyzed to determine the rate of the (sup 12)C((alpha),(gamma)) reaction. In the APEX collaboration, we have completed the assembly and testing of two position-sensitive Na barrels which surround the axial silicon detector arrays and serve as the e(sup +) triggers by detecting their back-to-back annihilation quanta were completed. The HI@AGS and RHIC collaborations, construction and implementation activities associated with the space-time-tracker detector and in the design of the central detector for the PHENIX experiment were carried out. Operation of the ESTU tandem accelerator has been reliable, delivering beam on target at terminal voltages as high as 19.3 MV and running for as long as 143 days between tank openings. Fabrication and bench testing of a new negative ion source system have been completed.

Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4.

Directory of Open Access Journals (Sweden)

Md Gulam Musawwir Khan

Full Text Available Php4 is a nucleo-cytoplasmic shuttling protein that accumulates in the nucleus during iron deficiency. When present in the nucleus, Php4 associates with the CCAAT-binding protein complex and represses genes encoding iron-using proteins. Here, we show that nuclear import of Php4 is independent of the other subunits of the CCAAT-binding complex. Php4 nuclear import relies on two functionally independent nuclear localization sequences (NLSs that are located between amino acid residues 171 to 174 (KRIR and 234 to 240 (KSVKRVR. Specific substitutions of basic amino acid residues to alanines within these sequences are sufficient to abrogate nuclear targeting of Php4. The two NLSs are biologically redundant and are sufficient to target a heterologous reporter protein to the nucleus. Under low-iron conditions, a functional GFP-Php4 protein is only partly targeted to the nucleus in imp1Δ and sal3Δ mutant cells. We further found that cells expressing a temperature-sensitive mutation in cut15 exhibit increased cytosolic accumulation of Php4 at the nonpermissive temperature. Further analysis by pull-down experiments revealed that Php4 is a cargo of the karyopherins Imp1, Cut15 and Sal3. Collectively, these results indicate that Php4 can be bound by distinct karyopherins, connecting it into more than one nuclear import pathway.

Studies in nuclear structure relevant to Astrophysics: theoretical and experimental efforts

International Nuclear Information System (INIS)

Saha Sarkar, Maitreyee

2016-01-01

Experimental and theoretical investigations in the region around doubly magic neutron rich 132 Sn nucleus have recently revealed many intriguing issues concerning some newer aspects of nuclear structure in such exotic environments. These nuclei lie on or close to the path of the astrophysical r-process flow. A glimpse of the implication of these studies on the r-process nucleosynthesis will be discussed. Presently, the Nuclear Physics group in Saha Institute of Nuclear Physics is working for installation of a high-current, low energy Accelerator as the primary component of the Facility for Research in low Energy Nuclear Astrophysics (FRENA), a national facility, at Kolkata. Planning for future experiments has been undertaken for successful utilization of this facility. Implantation technique has been found to be one of the most effective methods to produce isotopically pure targets. We have prepared a few isotopically pure targets using this technique. Being the slowest process of the CNO cycle, study of the 14 N(p, γ) 15 O(Q = 7297 keV) capture reaction is of high astrophysical interest. From an experiment utilizing one of the newly prepared 14 N implanted targets, a preliminary estimate of the lifetime of 6792 keV state in 15 O has been obtained, using Doppler shift attenuation method (DSAM). The sensitivity of the results with respect to the uncertainties in various input quantities has been tested. This endeavour will be helpful to design a better experiment to extract more precise lifetime for this important state

Experimental evaluation of an expert system for nuclear reactor operators

International Nuclear Information System (INIS)

Nelson, W.R.

1984-10-01

The United States Nuclear Regulatory Commission (USNRC) is supporting a program for the experimental evaluation of an expert system for nuclear reactor operators. A prototype expert system, called the Response Tree System, has been developed and implemented at INEL. The Response Tree System is designed to assess the status of a reactor system following an accident and recommend corrective actions to reactor operators. The system is implemented using color graphic displays and is driven by a computer simulation of the reactor system. Control of the system is accomplished using a transparent touch panel. Controlled experiments are being conducted to measure performance differences between operators using the Response Tree System and those not using it to respond to simulated accident situations. This paper summarizes the methodology and results of the evaluation of the Response Tree System, including the quantitative results obtained in the experiments thus far. Design features of the Response Tree System are discussed, and general conclusions regarding the applicability of expert systems in reactor control rooms are presented

Estatus de parámetros oxidativos y del gen p53 en sangre de niños en edad escolar de zonas afectadas por el accidente nuclear de Chernobyl.

OpenAIRE

García Mora, Mª Carmen

2004-01-01

RESUMEN Tras el accidente nuclear de Chernobyl producido el 26 de abril de 1986 se liberaron muchos radioisótopos, produciendo la contaminación del medio ambiente, con la consiguiente implicación sobre la salud de las personas afectadas. La irradiación produce su efecto sobre el material biológico de manera directa, como consecuencia inmediata de la ionización inducida por la irradiación y de manera indirecta, que al interaccionar sobre cualquier estructura celular, esencialmente el agua t...

Unique nuclear localization of Nile tilapia (Oreochromis niloticus) Neu4 sialidase is regulated by nuclear transport receptor importin α/β.

Science.gov (United States)

Honda, Akinobu; Chigwechokha, Petros Kingstone; Kamada-Futagami, Yuko; Komatsu, Masaharu; Shiozaki, Kazuhiro

2018-06-01

Sialidase catalyzes the removal of sialic acids from glycoconjugates. Different from Neu1 and Neu3 sialidases, Neu4 enzymatic properties such as substrate specificity and subcellular localization are not well-conserved among vertebrates. In fish only zebrafish and medaka neu4 genes have been cloned and their polypeptides have been characterized so far. Thus, characterization of Neu4 from other fish species is necessary to evaluate Neu4 physiological functions. Here, Nile tilapia was chosen for the characterization of Neu4 polypeptide considering that it is one of the major cultured fish all over the world and that its genomic sequences are now available. Coding DNA sequence of tilapia Neu4 was identified as 1,497 bp and its recombinant protein showed broad substrate specificity and optimal sialidase enzyme activity pH at 4.0. Neu4 activity was sustained even in neutral and alkali pH. Interestingly, immunofluorescence analysis revealed that major subcellular localization of tilapia Neu4 was nuclear, quite distinct from zebrafish (ER) and medaka Neu4 (lysosome). Bioinformatic analysis showed the existence of putative nuclear localization signal (NLS) in tilapia Neu4. In general, it is known that importin families bind to several proteins via NLS and transfer them into nucleus. Therefore, to determine the involvement of putative NLS in Neu4 nuclear localization, Neu4 mutant deleting NLS was constructed and expressed in cultured cells. As a result, NLS deletion significantly diminished the nuclear localization. Furthermore, treatment of importazole, interrupter of binding importin β and RanGTP, significantly suppressed Neu4 nuclear localization. In summary, tilapia Neu4 is a unique sialidase localized at nucleus and its transport system into nucleus is regulated by importin. Copyright © 2018 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Experimental validation of decay heat calculation codes and associated nuclear data libraries for fusion energy

International Nuclear Information System (INIS)

Maekawa, Fujio; Wada, Masayuki; Ikeda, Yujiro

2001-01-01

Validity of decay heat calculations for safety designs of fusion reactors was investigated by using decay heat experimental data on thirty-two fusion reactor relevant materials obtained at the 14-MeV neutron source facility of FNS in JAERI. Calculation codes developed in Japan, ACT4 and CINAC version 4, and nuclear data bases such as JENDL/Act-96, FENDL/A-2.0 and Lib90 were used for the calculation. Although several corrections in algorithms for both the calculation codes were needed, it was shown by comparing calculated results with the experimental data that most of activation cross sections and decay data were adequate. In cases of type 316 stainless steel and copper which were important for ITER, prediction accuracy of decay heat within ±10% was confirmed. However, it was pointed out that there were some problems in parts of data such as improper activation cross sections, e,g., the 92 Mo(n, 2n) 91g Mo reaction in FENDL, and lack of activation cross section data, e.g., the 138 Ba(n, 2n) 137m Ba reaction in JENDL. Modifications of cross section data were recommended for 19 reactions in JENDL and FENDL. It was also pointed out that X-ray and conversion electron energies should be included in decay data. (author)

Experimental validation of decay heat calculation codes and associated nuclear data libraries for fusion energy

Energy Technology Data Exchange (ETDEWEB)

Maekawa, Fujio; Wada, Masayuki; Ikeda, Yujiro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2001-01-01

Validity of decay heat calculations for safety designs of fusion reactors was investigated by using decay heat experimental data on thirty-two fusion reactor relevant materials obtained at the 14-MeV neutron source facility of FNS in JAERI. Calculation codes developed in Japan, ACT4 and CINAC version 4, and nuclear data bases such as JENDL/Act-96, FENDL/A-2.0 and Lib90 were used for the calculation. Although several corrections in algorithms for both the calculation codes were needed, it was shown by comparing calculated results with the experimental data that most of activation cross sections and decay data were adequate. In cases of type 316 stainless steel and copper which were important for ITER, prediction accuracy of decay heat within {+-}10% was confirmed. However, it was pointed out that there were some problems in parts of data such as improper activation cross sections, e,g., the {sup 92}Mo(n, 2n){sup 91g}Mo reaction in FENDL, and lack of activation cross section data, e.g., the {sup 138}Ba(n, 2n){sup 137m}Ba reaction in JENDL. Modifications of cross section data were recommended for 19 reactions in JENDL and FENDL. It was also pointed out that X-ray and conversion electron energies should be included in decay data. (author)

Study of deuteron photodisintegration with linearly polarized photons over the energy range E/sub el/ = 0. 4 to 0. 8 GeV

Energy Technology Data Exchange (ETDEWEB)

Agababyan, K.S.; Adamyan, F.V.; Akopyan, G.G.; Vartapetyan, G.A.; Galumyan, P.I.; Grabskii, V.O.; Karapetyan, V.V.; Karapetyan, G.V.; Kordonskii, M.S.

1985-06-01

We describe the experimental methods and the results of measurements of the asymmetry of the cross section of the eld pn reaction induced by linearly polarized photons over the energy range E/sub el/ = 0.4 to 0.8 GeV and proton angles in the c.m. system theta* = 45 to 95. Experiments were conducted on a two-arm spectrometer installation. The results obtained do not agree either with calculations within the framework of phenomenological models, or with predictions of a partial-wave analysis that includes the contribution of dibaryon resonances.

El receptor de estrógenos alfa como mediador del efecto proliferativo de progestágenos en cáncer de mama

Directory of Open Access Journals (Sweden)

Sebastián Giulianelli

2012-08-01

Full Text Available En carcinomas mamarios murinos (C4-HD y en células de cáncer de mama humano (T47D observamos que el progestágeno sintético, acetato de medroxiprogesterona (MPA, induce la activación del receptor de estrógenos alfa (REa y su asociación nuclear con el receptor de progesterona (RP. En este trabajo postulamos que dicha interacción a nivel genómico sería fundamental para desarrollar respuestas proliferativas mediadas por progestágenos. Demostramos que el antiestrógeno fulvestrant (FUL, ICI182.780 indujo la regresión completa de tumores C4-HD creciendo con MPA. El progestágeno indujo la expresión temprana de CCND1 y MYC en células T47D y este efecto fue revertido al bloquear el REa. En células tratadas con MPA utilizamos ensayos de inmunoprecipitación de la cromatina (ChIP y corroboramos la colocalización nuclear de RP/REa en los mismos sitios de los promotores de CCND1 y MYC. El ICI no afectó la unión de RP a ambas secuencias regulatorias, pero sí inhibió la unión del REa. Confirmamos la interacción nuclear entre REa y RP en muestras de cáncer de mama humano. Los resultados demuestran que la presencia del REa, interactuando con el RP, en promotores de CCND1 y MYC es fundamental para la transcripción génica y la proliferación celular inducida por el progestágeno.

Co-operation Agreement. The Text of the Agreement of 25 May 1998 between the International Atomic Energy Agency and the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials; Acuerdo de Cooperacion. Texto del Acuerdo de 25 de Mayo de 1998 entre el Organismo Internacional de Energia Atomica y la Agencia Brasileno-Argentina de Contabilidad y Control de Materiales Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-06-30

The text of the Co-operation Agreement between the International Atomic Energy Agency and the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials is reproduced herein for the information of all Members. The Agreement entered into force on 25 May 1998, pursuant to Article 8 [Spanish] El texto del Acuerdo de Cooperacion entre el Organismo Internacional de Energia Atomica y la Agencia Brasileno-Argentina de Contabilidad y Control de Materiales Nucleares se reproduce en el presente documento para informacion de todos los Miembros. El Acuerdo entro en vigor el 25 de mayo de 1998 en conformidad con lo dispuesto en el articulo 8.

Anemia y fiebre en el postrasplante renal: su relación con el parvovirus humano B19

Directory of Open Access Journals (Sweden)

Yanet Parodis López

2017-03-01

Presentamos el caso clínico de un varón de 65 años con trasplante renal de donante cadáver en septiembre de 2014. A los 38 días del trasplante comienza con anemia progresiva y resistente a los agentes estimulantes de la eritropoyesis. A los 64 días se produce hipertermia, con deterioro progresivo de su estado general. La serología vírica resultó negativa, al igual que la PCR inicial en sangre del parvovirus humano B19. A los 4 meses y 19 días se realiza una biopsia de médula ósea en la que se observan eritroblastos gigantes con inclusiones víricas nucleares compatibles con parvovirus, por lo que se realiza una PCR en dicho tejido que confirma el diagnóstico. Una segunda PCR en sangre resultó positiva. Tras el tratamiento con inmunoglobulinas intravenosas (IGIV y la suspensión temporal del micofenolato de mofetilo, se produce una remisión completa de la enfermedad, aunque persistía positiva la PCR para el parvovirus B19 en sangre, lo que hace necesario vigilar probables recidivas.

Overview of experimental work to ensure innovation of nuclear fuel for future advanced PWRs

International Nuclear Information System (INIS)

Zymak, J.; Valach, M.; Hejna, J.

2002-11-01

It is envisaged that advanced nuclear fuel will be operated in high burnup conditions, at a high linear power and at considerable mechanical fuel-cladding interactions. The report gives an overview of experimental work investigating phenomena that will affect APWR fuel, such as the manufacturing technology, thermal properties and safety requirements

Site of the First Spanish Nuclear Power Stations; Los Emplazamientos de las Primeras Centrales Nucleares Espanolas

Energy Technology Data Exchange (ETDEWEB)

Pascual, F.; Alonso, A.; Norena, S.; Sevilla, A. [Junta de Energia Nuclear, Madrid (Spain)

1967-09-15

(e), con reactor de agua en ebullicion y contencion por condensacion de vapor, y la central de Vandellos, de 480 MW(e), con reactor grafito-gas y diseno integrado del tipo EDF-4. Los dos primeros estan situados en el interior del pais, el tercero en la costa mediterranea. Se discuten los criterios convencionales y los relacionados con la seguridad, que se han utilizado en la seleccion. Se pone de relieve la influencia de la orografia espanola en el transporte del equipo pesado y su repercusion en la seleccion de emplazamientos para centrales nucleares. Se hace referencia a la experiencia obtenida en el transporte del equipo de la central de Zorita. Se analizan las dificultades practicas encontradas al aplicar unas determinadas normas de seguridad a emplazamientos de centrales de tipo y caracteristicas de diseno diferentes. Ya que el tipo de reactor y su sistema de contencion influyen en el valor practico de la aplicacion de unas determinadas normas que, ademas, han de adaptarse a las caracteristicas peculiares de cada nacion, se indica la conveniencia de utilizar de forma adecuada y flexible las normas de seguridad para el analisis de los emplazamientos de centrales nucleares. Se describen las caracteristicas geologicas y meteorologicas de los tres emplazamientos y se resumen los trabajos e investigaciones realizados en estos campos. En especial, se destacan los estudios de hidrologia realizados en el caso de Zorita y Santa Maria de Garofia, y se describen las estaciones meteorologicas montadas en ambos emplazamientos, los experimentos de difusion con globos equilibrados realizados en el caso de Santa Maria de Garofia y los resultados de estas investigaciones. (author)

Seminar on utilization of nuclear techniques in the agricultural research carried out in FONAIAP. Abstracts and lectures; Seminario sobre utilizacion de tecnicas nucleares en la investigacion agropecuaria realizada en el FONAIAP. Resumenes y ponencias

Energy Technology Data Exchange (ETDEWEB)

Romero S, Alfredo [ed.; Bracamonte, Magaly [Fondo Nacional de Investigaciones Agropecuarias (FONAIAP), Centro Nacional de Investigaciones Agropecuarias (CENIAP), Maracay (Venezuela)

1997-07-01

The lectures included in this seminar are related to: development and evaluation of prophylactic methods to control the anaplasmosis and babesiosis (babesia bovis) in the livestock; the diagnosis of bovine basesiosis (babesia bovis) by means of the test of ELISA; validation of the kit ELISA (FAO, OIEA, PANAFTOSA) to determine antibodies against the virus of the foot and mouth disease; variability generation in sugar cane for resistance to mosaic viruses and rusts (puccinia melanocephala) by means of the cultivation of explants and irradiated callus; bioavailabilty of deposit phosphates in animal feeding; biological fixation of nitrogen in three tropical feed crops leguminous and its transfer to Brachiaria humidicola in association; unit of stable isotopic N{sup 1}5 analysis; effect of the efficiency of N by use of different forms of fertilizer application in ground, evaluated by means of the isotopic technique and the N absorbed by the cultivation; application of progesterone and testosterone in the diagnose and control of reproduction in crossbreeds animal husbandry; advances in the monitoring of production systems in double purpose cattle raising in the area of Guayabal, Guarico State; aquatic investigations with nuclear energy techniques; development of the Venezuelan Edaphological Bibliographic Database. [Spanish] Las ponencias presentadas en este seminario tratan sobre: desarrollo y evaluacion de metodos profilacticos para controlar la anaplasmosis y babesiosis en el ganado; el diagostico de la babesiosis bovina (babesia bovis) mediante la prueba de ELISA; la validacion del kit de ELISA FAO/OIEA/PANAFTOSA para determinar anticuerpos contra el virus de la fiebre aftosa; generacion de variabilidad en cana de azucar para resistencia a mosaico y roya (puccinia melanocephala) mediante el cultivo de explantes y callos irradiados; biodisponibilidad de fosfatos de yacimientos en la alimentacion animal; fijacion biologica de nitrogeno en tres leguminosas forrajeras

Ukrainian Nuclear Data Centre Progress Report, 2010/11. Summary of Nuclear Data Studies by Staff of the Ukrainian Nuclear Data Centre

International Nuclear Information System (INIS)

Gritzay, O.

2011-01-01

Full text: Ukrainian Nuclear Data Centre (UkrNDC) is subdivision within the Neutron Physics Department at the Institute for Nuclear Research of the National Academy of Sciences of Ukraine. UkrNDC has 5 permanent researchers. During year under review three members of the staff were involved in experimental neutron data measurements at the Kyiv research reactor. Compilation: We continue collection and compilation of experimental neutron, charged particle and photonuclear data. Number of the EXFOR's entries sent to the NDS IAEA by UkrNDC are the following. New: for neutron data - 1 entries (32231); for charged particle data - 4 entries (D5074, D5075, D5077, D5078); for photonuclear data - 4 entries (G4030 - G4033). Improved: for neutron data - 5 entries (32217, 32219, 32222 - 32224); for charged particle data - 15 entries (D5001, D5002, D5023, D5030, D5039- D5042, D5051, D5066 - D5068, D5070, D5071, D5073); for photonuclear data - 2 entries (G4011, G4018). We realize review of compilation scope in home journals: ''Nuclear Physics and Atomic Energy''; ''Ukrainian Journal of Physics''; ''Problems of Atomic Science and Technology'', Series ''Nuclear Physics Investigations''. Collaboration: We continue our collaboration with the Nuclear Physics Department of the Taras Shevchenko National University of Kyiv. The teaching course 'Nuclear Data for Science and Technology and modern computer codes for nuclear data processing' (36 hours) has been lectured in 2010-2011 for the fifth-course students of NPD KNU. This course includes the following items: ENDF/B libraries, EXROR system, ENSDF library, the use of the PREPRO code in work with the ENDF libraries, the introduction to NJOY code system, the Network of Nuclear Reaction Data Centers and the use of the on-line services; The teaching courses 'Neutron Physics' (72 hours) and 'Neutron Physics at the Kyiv Research Reactor' (experimental work, 36 hours) are lectured in 2010-2011 for fourth-year students of NPD KNU; The teaching

Desarrollo de proveedores para la industria nuclear argentina Visión desde las Centrales Nucleares

Directory of Open Access Journals (Sweden)

DOMINGO QUILICI

2013-06-01

Full Text Available Frente al inicio de una nueva etapa en la instalación de capacidad núcleo eléctrica en el país, se recorrerá la historia del desarrollo de la industria nuclear nacional (1964-1986 en búsqueda de antecedentes útiles para esta nueva realidad. Partiendo de la intención de dar repuesta a las preguntas: ¿Por qué se decidió tan tempranamente construir una central nuclear (en adelante CN; ¿por qué se decidió comprarla con una modalidad particular de los contratos “llave en mano”, en vez del desarrollo de una versión “criolla”? Y cuál fue el significado de la apertura del “paquete tecnológico” en aquel momento; se indagará sobre los antecedentes del desarrollo de proveedores para la industria nuclear en la Argentina. Se describirán las acciones que llevaron a la compra de las centrales de Atucha I, Embalse y Atucha II y como a partir de esas decisiones se implementaron políticas para maximizar la participación nacional en la construcción de las mismas y para la transferencia de tecnología del exterior hacia la industria local. Se analizará el Plan Nuclear puesto en vigencia a fines de los años setenta, desde el punto de vista de su influencia sobre el desarrollo tecnológico endógeno. Abstract The history of the development of national nuclear industry (1964-1986 will be reviewed in the search of useful patterns for the present new phase in the installation of nucleo-electric capacity in the country Precedents of development of suppliers for the argentinean nuclear industry will be considered, taking as starting point the following questions: Why the early decision of constructing a Nuclear Power Plant was taken? Why was it decided to buy it under a peculiar version of a turnkey contract instead of developing a “native” design? What were the implications of opening “technological packages” at that time? Actions leading to the construction of Atucha I, Embalse and Atucha II stations will be described, as well

Computer techniques for experimental work in GDR nuclear power plants with WWER

International Nuclear Information System (INIS)

Stemmler, G.

1985-01-01

Nuclear power plant units with WWER are being increasingly equipped with high-performance, programmable process control computers. There are, however, essential reasons for further advancing the development of computer-aided measuring systems, in particular for experimental work. A special structure of such systems, which is based on the division into relatively rigid data registration and primary handling and into further processing by advanced programming language, has proved useful in the GDR. (author)

Progress in nuclear measuring and experimental techniques by application of microelectronics. 1

International Nuclear Information System (INIS)

Meiling, W.

1984-01-01

In the past decade considerable progress has been made in nuclear measuring and experimental techniques by developing position-sensitive detector systems and widely using integrated circuits and microcomputers for data acquisition and processing as well as for automation of measuring processes. In this report which will be published in three parts those developments are reviewed and demonstrated on selected examples. After briefly characterizing microelectronics, the use of microelectronic elements for radiation detectors is reviewed. (author)

Status of the nuclear sector in Spain Situación del sector nuclear en España

Directory of Open Access Journals (Sweden)

Antonio González Jiménez

2010-12-01

Full Text Available Spain began to show interest in nuclear energy in the late 1940’s. In 1964 the Nuclear Energy Law was approved, and in 1972 the Nuclear and Radioactive Sites Regulation was developed. Safety and regulation activities were entrusted to the Nuclear Safety Council (Consejo de Seguridad Nuclear created in 1980, and the research and management of radioactive waste to the National Radioactive Waste Company (Empresa Nacional de Residuos Radiactivos, created in 1985. The structure of Spain’s nuclear industry began to be created in the 1960’s, as a consequence of the decision to build the nuclear power plants of José Cabrera, Santa María de Garoña and Vandellós I. In the next stage, during the 1970’s, the Almaraz, Ascó and Cofrentes Nuclear Power Plants were built. During the third stage, in the 1980’s, the Vandellós II and Trillo I Nuclear Power Plants were built. Nowadays, the expert and efficient Spanish nuclear industry is a guarantee that nuclear technology is maintained in Spain, and not only to support the operating plants but also a reactivated international nuclear market. Spain has the necessary infrastructure, the technical capacity, the financial resources and the companies’ willpower in a common effort to provide Spaniards with reliable, cheap and sustainable electric energy that respects the environment and guarantees security for citizens. Nuclear energy is, definitively, a key component today and in the future.España comenzó a interesarse por la energía nuclear a finales de los años cuarenta. En el año 1964 se aprobó la Ley de Energía Nuclear, y en el año 1972 se desarrolló el Reglamento de Instalaciones Nucleares y Radiactivas. Las actividades de seguridad y regulación se encomendaron al Consejo de Seguridad Nuclear, creado en 1980, y la investigación y gestión de los residuos radiactivos a la Empresa Nacional de Residuos Radiactivos (ENRESA, creada en 1985. La estructura industrial nuclear en España comenz

La sostenibilidad y el debate nuclear

Directory of Open Access Journals (Sweden)

Amparo Vilches

2008-01-01

Full Text Available Las centrales nucleares están siendo presentadas como “solución verde” al problema energético, debido a que no conllevan emisiones de CO2. En este artículo se pretende poner de manifiesto que, sin embargo, esta indudable ventaja va acompañada de muy serios inconvenientes que obligan a rechazar la opción nuclear.

The role of nuclear law in nuclear safety after Fukushima; El rol del derecho nuclear en seguridad nuclear luego de Fukushima

Energy Technology Data Exchange (ETDEWEB)

Cardozo, Diva E. Puig, E-mail: d.puig@adinet.com.uy [International Nuclear Law Association (INLA), Montevideo (Uruguay)

2013-07-01

The paper contains the following topics: nuclear law, origin and evolution, role of the legal instruments on nuclear safety, nuclear safety the impact of major nuclear accidents: Chernobyl and Fukushima. The response of the nuclear law post Fukushima. Safety and security. International framework for nuclear safety: nuclear convention joint convention on safety on spent fuel management and on the safety of radioactive waste management. The Fukushima World Conference on Nuclear Safety. Convention on Prompt Notification and Assistance in case of a Nuclear Accident or Radiological Emergency. Plan of Action for Nuclear Safety. IAEA recommendations for the safety transport of radioactive material. International framework for nuclear security. Convention on the Physical Protection of Nuclear Materials. International Convention for the Suppression of Acts Against Nuclear Terrorism. Resolution No. 1540 of the Security Council of United Nations (2004). Measures to strengthen international safety. Code of conduct on the safety research reactor.

10 CFR 1017.4 - Definitions.

Science.gov (United States)

2010-01-01

..., experimental, or research-related part, subsection, design, or material used in the manufacture or utilization... General Overview § 1017.4 Definitions. As used in this part: Atomic Energy Act means the Atomic Energy Act... material in the research, development, production, or testing of nuclear weapons, nuclear weapon components...

NR4A nuclear receptors are orphans but not lonesome.

Science.gov (United States)

Kurakula, Kondababu; Koenis, Duco S; van Tiel, Claudia M; de Vries, Carlie J M

2014-11-01

The NR4A subfamily of nuclear receptors consists of three mammalian members: Nur77, Nurr1, and NOR-1. The NR4A receptors are involved in essential physiological processes such as adaptive and innate immune cell differentiation, metabolism and brain function. They act as transcription factors that directly modulate gene expression, but can also form trans-repressive complexes with other transcription factors. In contrast to steroid hormone nuclear receptors such as the estrogen receptor or the glucocorticoid receptor, no ligands have been described for the NR4A receptors. This lack of known ligands might be explained by the structure of the ligand-binding domain of NR4A receptors, which shows an active conformation and a ligand-binding pocket that is filled with bulky amino acid side-chains. Other mechanisms, such as transcriptional control, post-translational modifications and protein-protein interactions therefore seem to be more important in regulating the activity of the NR4A receptors. For Nur77, over 80 interacting proteins (the interactome) have been identified so far, and roughly half of these interactions has been studied in more detail. Although the NR4As show some overlap in interacting proteins, less information is available on the interactome of Nurr1 and NOR-1. Therefore, the present review will describe the current knowledge on the interactomes of all three NR4A nuclear receptors with emphasis on Nur77. Copyright © 2014 Elsevier B.V. All rights reserved.

Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells.

Science.gov (United States)

Ku, H; Meier, K E

2000-04-14

Intracellular signals can regulate cell adhesion via several mechanisms in a process referred to as "inside-out" signaling. In phorbol ester-sensitive EL4 thymoma cells, phorbol-12-myristate 13-acetate (PMA) induces activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases and promotes cell adhesion. In this study, clonal EL4 cell lines with varying abilities to activate ERKs in response to PMA were used to examine signaling events occurring downstream of ERK activation. Paxillin, a multifunctional docking protein involved in cell adhesion, was phosphorylated on serine/threonine residues in response to PMA treatment. This response was correlated with the extent and time course of ERK activation. PMA-induced phosphorylation of paxillin was inhibited by compounds that block the ERK activation pathway in EL4 cells, primary murine thymocytes, and primary murine splenocytes. Paxillin was phosphorylated in vitro by purified active ERK2. Two-dimensional electrophoresis revealed that PMA treatment generated a complex pattern of phosphorylated paxillin species in intact cells, some of which were generated by ERK-mediated phosphorylation in vitro. An ERK pathway inhibitor interfered with PMA-induced adhesion of sensitive EL4 cells to substrate. These findings describe a novel inside-out signaling pathway by which the ERK cascade may regulate events involved in adhesion.

Nuclear Criticality Experimental Research Center (NCERC) Overview

Energy Technology Data Exchange (ETDEWEB)

Goda, Joetta Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Grove, Travis Justin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes, David Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Myers, William L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sanchez, Rene Gerardo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-03-03

The mission of the National Criticality Experiments Research Center (NCERC) at the Device Assembly Facility (DAF) is to conduct experiments and training with critical assemblies and fissionable material at or near criticality in order to explore reactivity phenomena, and to operate the assemblies in the regions from subcritical through delayed critical. One critical assembly, Godiva-IV, is designed to operate above prompt critical. The Nuclear Criticality Experimental Research Center (NCERC) is our nation’s only general-purpose critical experiments facility and is only one of a few that remain operational throughout the world. This presentation discusses the history of NCERC, the general activities that makeup work at NCERC, and the various government programs and missions that NCERC supports. Recent activities at NCERC will be reviewed, with a focus on demonstrating how NCERC meets national security mission goals using engineering fundamentals. In particular, there will be a focus on engineering theory and design and applications of engineering fundamentals at NCERC. NCERC activities that relate to engineering education will also be examined.

Cost comparison of 4x500 MW coal-fuelled and 4x850 MW CANDU nuclear generating stations

International Nuclear Information System (INIS)

Costa, M.

1981-01-01

The lifetime costs for a 4x850 MW CANDU generating station are compared to those for 4x500 MW bituminous coal-fuelled generating stations. Two types of coal-fuelled stations are considered; one burning U.S. coal which includes flue gas desulfurization and one burning Western Canadian coal. Current estimates for the capital costs, operation and maintenance costs, fuel costs, decommissioning costs and irradiated fuel management costs are shown. The results show: (1) The accumulated discounted costs of nuclear generation, although initially higher, are lower than coal-fuelled generation after two or three years. (2) Fuel costs provide the major contribution to the total lifetime costs for coal-fuelled stations whereas capital costs are the major item for the nuclear station. (3) The break even lifetime capacity factor between nuclear and U.S. coal-fuelled generation is projected to be 5%; that for nuclear and Canadian coal-fuelled generation is projected to be 9%. (4) Large variations in the costs are required before the cost advantage of nuclear generation is lost. (5) Comparison with previous results shows that the nuclear alternative has a greater cost advantage in the current assessment. (6) The total unit energy cost remains approximately constant throughout the station life for nuclear generation while that for coal-fuelled generation increases significantly due to escalating fuel costs. The 1978 and 1979 actual total unit energy cost to the consumer for several Ontario Hydro stations are detailed, and projected total unit energy costs for several Ontario Hydro stations are shown in terms of escalated dollars and in 1980 constant dollars

Proposal for a strategic management plan for experimental agricultural and academic farm "El Cairo" of Arauca

Directory of Open Access Journals (Sweden)

Elías Nieves

2014-04-01

Full Text Available This paper presents a design for a strategic management plan for the Experimental Agricultural and Academic Farm: El Cairo of the Universidad Nacional de Colombia, Orinoquía branch. A non-experimental methodological design was used, from which a situational analysis of the farm was generated, which was used as a basis to formulate and design a Strategic Management plan for a five-year period. It was concluded that the current organization and management plan does not meet the mission objectives of research, teaching, and continuing education, suggesting a need for the articulation of the farm with the administrative and academic structure of the university in carrying out the strategic management plan derived from the current research.

Proposed experimental test of Bell's inequality in nuclear beta decay

International Nuclear Information System (INIS)

Skalsey, M.

1986-01-01

A β decay experiment is proposed for testing Bell's inequality, related to hidden-variables alternatives to quantum mechanics. The experiment uses Mott scattering for spin polarization analysis of internal conversion electrons. Beta-decay electrons, in cascade with the conversion electrons, are longitudinally polarized due to parity violation in the weak interaction. So simply detecting the β electron direction effectively measures the spin. A two-particle spin-spin correlation can thus be investigated and related, within certain assumptions, to Bell's inequality. The example of 203 Hg decay is used for a calculation of expected results. Specific problems related to nuclear structure and experimental inconsistencies are also discussed

Diseño de placas solares e implementación de un transmisor experimental AX.25 para el 3Cat-1

OpenAIRE

Gonzalvez Foguet, Ricard

2016-01-01

Explains the design and construction of two types of solar panels for the 3cat1, one type based on commercial high efficiency multi-junction solar cells and other based in UPC Electronic Engineering Department in-house developed solar cells. Also describes the design and implementation of a microcontroller based experimental transmitter to send data packets to the 3cat1 ground station. Diseño y construcción de dos tipos de paneles solares para el 3cat1, el primero basado en celulas solares...

Forming Limit Diagrams of Zircaloy-4 and Zirlo Sheets for Stamping of Spacer Grids of Nuclear Fuel Rods

International Nuclear Information System (INIS)

Seo, Yun Mi; Hyun, Hong Chul; Lee, Hyung Yil; Kim, Nak Soo

2011-01-01

In this work, we investigated the theoretical forming limit models for Zircaloy-4 and Zirlo used for spacer grid of nuclear fuel rods. Tensile and anisotropy tests were performed to obtain stress-strain curves and anisotropic coefficients. The experimental forming limit diagrams (FLD) for two materials were obtained by dome stretching tests following NUMISHEET 96. Theoretical FLD depends on FL models and yield criteria. To obtain the right hand side (RHS) of FLD, we applied the FL models (Swift's diffuse necking, M-K theory, S-R vertex theory) to Zircaloy-4 and Zirlo sheets. Hill's local necking theory was adopted for the left hand side (LHS) of FLD. To consider the anisotropy of sheets, the yield criteria of Hill and Hosford were applied. Comparing the predicted curves with the experimental data, we found that the RHS of FLD for Zircaloy-4 can be described by the Swift model (with the Hill's criterion), while the LHS of the FLD can be explained by Hill model. The FLD for Zirlo can be explained by the S-R model and the Hosford's criterion (a = 8)

Charge state distribution of 16O from the 4He(12C,16O)γ reaction of astrophysical interest studied both experimentally and theoretically

International Nuclear Information System (INIS)

Liu, Shengjin; Sakurai, Makoto; Sagara, Kenshi; Teranishi, Takashi; Fujita, Kunihiro; Yamaguchi, Hiroyuki; Matsuda, Sayaka; Mitsuzumi, Tatsuki; Iwazaki, Makoto; Rosary, Mariya T.; Kato, Daiji; Tolstikhina, I.Yu.

2014-01-01

In astrophysics, 4 He( 12 C, 16 O)γ reaction places an important role. At Kyushu University Tandem accelerator Laboratory (KUTL), the measurement of 4 He( 12 C, 16 O)γ cross section is in progress in the energy range of astrophysical nuclear reaction. Since the charge state of product 16 O ions after passing through the gas target is spread and only one charge state can be measured at terminal detector, it is necessary to know the charge state distribution of 16 O ions passing through the He gas target precisely. Here, we report the charge state distribution of the 16 O recoils both experimentally and theoretically. Experimentally, we measured the equilibrium charge state distribution of 16 O ions in the windowless helium gas target with the beam energy of primary 16 O ions at 7.2, 4.5, and 3.45 MeV at KUTL. The measured results showed a Gaussian distribution for the charge state fraction. Theoretically, we proposed a framework for the charge state distribution study. Charge state distribution was computed by solving a set of differential equations including a series of charge exchange cross sections. For the ionization cross section, plane-wave Born approximation was applied and modified by taking target atomic screening as a function of momentum transfer into account. For the capture cross section, continuum distorted wave approximation was applied and the influence of the gas target density was taken into account in the process of electron capture. Using above charge exchange cross sections, the charge state evolution was simulated. According to the equilibrium distribution, we compared the theoretical calculation to the experimental data. After taking into account the density effects in the charge exchange process, the theoretical charge state distributions shows a good agreement with the experimental data. Both experimental and theoretical results are useful to understand the charge fraction of recoil oxygen created via 4 He( 12 C, 16 O)γ reaction

Can Experimental Scientists, Data Evaluators and Compilers, and Nuclear Data Users Understand One Another?

Energy Technology Data Exchange (ETDEWEB)

Usachev, L. N. [Institute of Physics and Energetics, Obninsk, USSR (Russian Federation)

1966-07-01

The International Atomic Energy Agency organizes conferences on a wide variety of scientific subjects, all of which are of fundamental importance for the development of nuclear power. These include the technology of fuel elements, their stability in neutron fields, and chemical reprocessing as well as reactor physics, mathematical computational methods and the problems of protection and dosimetry. The problem of microscopic nuclear data, an essential aspect of reactor work, is just one of these many subjects. On the other hand, it should be remembered that the possibility of releasing nuclear energy was established in the first place by obtaining nuclear data on the fission process occurring in the uranium nucleus following the capture of a neutron and on the escape of the 2-3 secondary fission neutrons. In early nuclear power work the information provided by nuclear data was of considerable, even of decisive, importance. For example, the information available on the neutron balance in fast reactors showed that such reactors could operate as breeders and thus that it was worth while developing them. Strictly speaking, it is of course difficult to speak of a knowledge of nuclear data at this early period. It is perhaps more accurate to speak of the understanding of and the feeling for such data which grew up on the basis of the existing physical ideas on the fission of the nucleus, radiative capture and neutron scattering. Experimental data were very scanty but for that reason they were particularly valuable.

Can Experimental Scientists, Data Evaluators and Compilers, and Nuclear Data Users Understand One Another?

International Nuclear Information System (INIS)

Usachev, L.N.

1966-01-01

The International Atomic Energy Agency organizes conferences on a wide variety of scientific subjects, all of which are of fundamental importance for the development of nuclear power. These include the technology of fuel elements, their stability in neutron fields, and chemical reprocessing as well as reactor physics, mathematical computational methods and the problems of protection and dosimetry. The problem of microscopic nuclear data, an essential aspect of reactor work, is just one of these many subjects. On the other hand, it should be remembered that the possibility of releasing nuclear energy was established in the first place by obtaining nuclear data on the fission process occurring in the uranium nucleus following the capture of a neutron and on the escape of the 2-3 secondary fission neutrons. In early nuclear power work the information provided by nuclear data was of considerable, even of decisive, importance. For example, the information available on the neutron balance in fast reactors showed that such reactors could operate as breeders and thus that it was worth while developing them. Strictly speaking, it is of course difficult to speak of a knowledge of nuclear data at this early period. It is perhaps more accurate to speak of the understanding of and the feeling for such data which grew up on the basis of the existing physical ideas on the fission of the nucleus, radiative capture and neutron scattering. Experimental data were very scanty but for that reason they were particularly valuable

Nuclear and nucleolar localization signals and their targeting function in phosphatidylinositol 4-kinase PI4K230

International Nuclear Information System (INIS)

Kakuk, Annamaria; Friedlaender, Elza; Vereb, Gyoergy; Lisboa, Duarte; Bagossi, Peter; Toth, Gabor; Gergely, Pal; Vereb, Gyoergy

2008-01-01

PI4K230, an isoform of phosphatidylinositol 4-kinase, known primarily as a cytoplasmic membrane-bound enzyme, was detected recently also in the nucleolus of several cells. Here we provide mechanistic insight on the targeting function of its putative nuclear localization signal (NLS) sequences using molecular modeling, digitonin-permeabilized HeLa cells and binding to various importins. The synthetic sequence 916 NFNHIHKRIRRVADKYLSG 934 comprising a putative monopartite NLS (NLS1), targeted covalently bound fluorescent BSA to the nucleoplasm via classical importin α/β mechanism employing importins α1 and α3 but not α5. This transport was inhibited by wheat germ agglutinin and GTPγS. The sequence 1414 SKKTNRGSQLHKYYMKRRTL 1433 , a putative bipartite NLS (NLS2) proved ineffective in nuclear targeting if conjugated to fluorescently labeled BSA. Nonetheless, NLS2 or either of its basic clusters directed to the nucleolus soybean trypsin inhibitor that can pass the nuclear pore complex passively; moreover, an expressed 58 kDa fragment of PI4K230 (AA1166-1667) comprising NLS2 was also imported into the nucleus by import factors of reticulocyte lysate or by importin α1/β or α3/β complexes and localized to the nucleolus. We conclude that the putative bipartite NLS itself is a nucleolar targeting signal, and for nuclear import PI4K230 requires a larger sequence around it or, alternatively, the monopartite NLS

Los Discursos de Legitimación de la Industria Nuclear Española

Directory of Open Access Journals (Sweden)

Luis Sánchez Vázquez

2009-06-01

Full Text Available La controversia sobre el uso de la energía nuclear es un tema clave en el actual debate sobre el modelo energético. El análisis de esta situación desde la perspectiva de los estudios de Ciencia y Tecnología para la Pazayuda a esclarecer ciertos condicionantes de la introducción y desarrollo de opción energética en nuestro país y en el contexto internacional, con objeto de contribuir al  esclarecimiento de ciertas posiciones dentro del panorama energético actual. En este marco, el trabajo intenta recoger la evolución del discurso de la industria nuclear española sobre los principales focos conflictivos asociados a la energía nuclear, a través del análisis de las publicaciones del Foro de la Industria Nuclear Española durante el periodo de mayor auge de dicha industria y la comparación con el discurso actual. Para ello han sido escogidos los documentos publicados por el Foro Nuclear en los periodos 1963-1977 y 2000-2004, de cuyo análisis se desprende una evolución notable de las posiciones en temas como la opinión pública o el cambio climático; ciertos cambios en los argumentos sobre los costes de generación nucleares o la seguridad de las centrales; mientras que el discurso permanece muy similar en una cuestión central como los residuos.

APMO: UN PROGRAMA COMPUTACIONAL PARA EL ESTUDIO DE EFECTOS CUÁNTICOS NUCLEARES MEDIANTE LA TEORÍA DEL ORBITAL MOLECULAR ELECTRÓNICO Y NO ELECTRÓNICO.

Directory of Open Access Journals (Sweden)

Sergio González

2009-04-01

Full Text Available Con el fin de estudiar teóricamente fenómenos en donde los núcleos atómicos presentan comportamiento cuántico, hemos desarrollado el paquete computacional APMO (Any-Particle Molecular Orbital. Este implementa el método de orbitales moleculares nucleares y electrónicos (OMNE a un nivel de teoría Hartree-Fock (HF, en el que tanto núcleos como electrones se representan como funciones de onda.Para comprobar la correcta implementación del método, se realizaron  cálculos de estructura electrónica regular y núcleo-electrónica de las moléculas H2 y LiH. Las componentes de energía calculadas siguen las  tendencias y están en el mismo orden de magnitud de cálculos similares reportados en la literatura.A diferencia de otros paquetes que implementan el método OMNE, el nuestro fué diseñado para estudiar sistemas con cualquier número de especies cuánticas. 

[Experimental nuclear physics]. Final report

International Nuclear Information System (INIS)

1991-04-01

This is the final report of the Nuclear Physics Laboratory of the University of Washington on work supported in part by US Department of Energy contract DE-AC06-81ER40048. It contains chapters on giant dipole resonances in excited nuclei, nucleus-nucleus reactions, astrophysics, polarization in nuclear reactions, fundamental symmetries and interactions, accelerator mass spectrometry (AMS), ultra-relativistic heavy ions, medium energy reactions, work by external users, instrumentation, accelerators and ion sources, and computer systems. An appendix lists Laboratory personnel, a Ph. D. degree granted in the 1990-1991 academic year, and publications. Refs., 41 figs., 7 tabs

[Experimental nuclear physics]. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1991-04-01

This is the final report of the Nuclear Physics Laboratory of the University of Washington on work supported in part by US Department of Energy contract DE-AC06-81ER40048. It contains chapters on giant dipole resonances in excited nuclei, nucleus-nucleus reactions, astrophysics, polarization in nuclear reactions, fundamental symmetries and interactions, accelerator mass spectrometry (AMS), ultra-relativistic heavy ions, medium energy reactions, work by external users, instrumentation, accelerators and ion sources, and computer systems. An appendix lists Laboratory personnel, a Ph. D. degree granted in the 1990-1991 academic year, and publications. Refs., 41 figs., 7 tabs.

Communications Received from Certain Member States Regarding Guidelines for the Export of Nuclear Material, Equipment and Technology. Nuclear Transfers and Nuclear-Related Dual-Use Transfers; Comunicaciones Recibidas De Diversos Estados Miembros Relativas A Las Directrices Para La Exportacion De Tecnologia, Equipo Y Materiales Nucleares. Transferencias Nucleares Y Transferencias De Equipo, Materiales V Tecnologia Afin Al Doble Uso En Materia Nuclear

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-04-15

The Director General has received a Note Verbale dated 5 March 1993 from the Ministry of Foreign Affairs of the Slovak Republic. The purpose of the Note Verbale is to provide information on that Governments' guidelines for Nuclear Transfers and for Transfers of of Nuclear-related Dual-use Equipment, Material and Related Technology. In the light of the wish expressed at the end of each Note Verbale, the text of the Note Verbale is annexed hereto [Spanish] El Director General ha recibido una nota verbal de fecha 5 de marzo de 1993 del Ministerio de Relaciones Exteriores de la RepUblica Eslovaca. El objetivo de la nota verbal es proporcionar informaciOn sobre las Directrices para las transferencias nucleares y las Directrices para la transferencia de equipo, materiales y tecnologia afin al doble uso en materia nuclear, de dicho Gobierno. Atendiendo a los deseos expresados al final de la nota verbal, se adjunta al presente documento el texto de la nota verbal.

Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam

International Nuclear Information System (INIS)

Hall, David C; Paganetti, Harald; Makarova, Anastasia; Gottschalk, Bernard

2016-01-01

A proton pencil beam is associated with a surrounding low-dose envelope, originating from nuclear interactions. It is important for treatment planning systems to accurately model this envelope when performing dose calculations for pencil beam scanning treatments, and Monte Carlo (MC) codes are commonly used for this purpose. This work aims to validate the nuclear models employed by the Geant4 MC code, by comparing the simulated absolute dose distribution to a recent experiment of a 177 MeV proton pencil beam stopping in water. Striking agreement is observed over five orders of magnitude, with both the shape and normalisation well modelled. The normalisations of two depth dose curves are lower than experiment, though this could be explained by an experimental positioning error. The Geant4 neutron production model is also verified in the distal region. The entrance dose is poorly modelled, suggesting an unaccounted upstream source of low-energy protons. Recommendations are given for a follow-up experiment which could resolve these issues. (note)

¿Comprendemos realmente el significado del ALCA?

OpenAIRE

Orlando Zelaya Martínez; Luis Murillo Orozco

2004-01-01

Después de finalizada la segunda guerra mundial, Estados Unidos se convierte en el gendarme del mundo tanto en lo económico como en lo político, razón por cual decide no únicamente convertirse en el banquero del mundo, sino en su salvador ante el potencial peligro que representaba el comunismo como sistema. De esta forma crea un nuevo tipo de guerra de intensidad en el enfrentamiento directo, pero trasladando tal circunstancia al campo de la amenaza nuclear. Nos estamos refiriendo a la "Guerr...

Computational and Experimental Study on Molecular Structure of Benzo[g]pyrimido[4,5-b]quinoline Derivatives: Preference of Linear over the Angular Isomer

Directory of Open Access Journals (Sweden)

Jorge Trilleras

2017-09-01

Full Text Available A series of 5-aryl-2-methylthio-5,12-dihydrobenzo[g]pyrimido[4,5-b]quinoline-4,6,11(3H-trione was synthesized through an environmental friendly multicomponent methodology and characterized with FT-IR (Fourier Transform infrared spectroscopy, 1H NMR (Nuclear Magnetic Resonance , 13C NMR and GC-MS (gas chromatography-mass spectrometry. The 5-(4-methoxyphenyl-2-methylthio-5,12-dihydrobenzo[g]pyrimido[4,5-b]quinoline-4,6,11(3H-trione 4c compound was characterized by X-ray single crystal diffraction. The geometry of 4c has been fully optimized using DFT (Density functional theory, B3LYP functional and 6-31G(d,p basis set, thus establishing the ground state energy and thermodynamic features for the mentioned compound, which are in accordance with the experimental data and the crystal structure. The experimental results reveal a strong preference for the regioselective formation of 4c linear four fused rings over the angular four fused and suggest a possible kinetic control in product formation.

Inteligencia emocional: Su relación con el rendimiento académico en preadolescentes de la Escuela 4 de Abril, de Io ciclo, Angola

Directory of Open Access Journals (Sweden)

María Domingas Cassinda Vissupe

2017-01-01

Full Text Available La investigación fue realizada con el objetivo de caracterizar la expresión de la inteligencia emocional (en lo sucesivo IE en preadolescentes con bajo rendimiento académico, de la escuela “4 de Abril”, de la provincia de Huambo, Angola. Se asumió un paradigma mixto, predominantemente cuantitativo, con un diseño no experimental, transversal y un tipo de estudio exploratorio. Se efectuó un muestreo no probabilístico, se seleccionó una muestra de 60 preadolescentes, 30 con bajo rendimiento (en lo sucesivo GE y 30 con rendimiento medio (en lo sucesivo GC. Para la recogida de los datos se aplicó el Trait Meta-Mood Scale, Informe escolar, conflicto de diálogo y composición. La Inteligencia Emocional mostró resultados diferentes en ambos grupos de preadolescentes, en términos de percepción, comprensión y facilitación, siendo mejores en el grupo de desempeño académico medio. Se reveló que las mayores dificultades fueron apreciadas en la regulación emocional.

Experimental test of nuclear magnetization distribution and nuclear structure models

International Nuclear Information System (INIS)

Beirsdorfer, P; Crespo-Lopez-Urrutia, J R; Utter, S B.

1999-01-01

Models exist that ascribe the nuclear magnetic fields to the presence of a single nucleon whose spin is not neutralized by pairing it up with that of another nucleon; other models assume that the generation of the magnetic field is shared among some or all nucleons throughout the nucleus. All models predict the same magnetic field external to the nucleus since this is an anchor provided by experiments. The models differ, however, in their predictions of the magnetic field arrangement within the nucleus for which no data exist. The only way to distinguish which model gives the correct description of the nucleus would be to use a probe inserted into the nucleus. The goal of our project was to develop exactly such a probe and to use it to measure fundamental nuclear quantities that have eluded experimental scrutiny. The need for accurately knowing such quantities extends far beyond nuclear physics and has ramifications in parity violation experiments on atomic traps and the testing of the standard model in elementary particle physics. Unlike scattering experiments that employ streams of free particles, our technique to probe the internal magnetic field distribution of the nucleus rests on using a single bound electron. Quantum mechanics shows that an electron in the innermost orbital surrounding the nucleus constantly dives into the nucleus and thus samples the fields that exist inside. This sampling of the nucleus usually results in only minute shifts in the electron s average orbital, which would be difficult to detect. By studying two particular energy states of the electron, we can, however, dramatically enhance the effects of the distribution of the magnetic fields in the nucleus. In fact about 2% of the energy difference between the two states, dubbed the hyperfine splitting, is determined by the effects related to the distribution of magnetic fields in the nucleus, A precise measurement of this energy difference (better than 0.01%) would then allow us to place

Handbook of nuclear engineering: vol 1: nuclear engineering fundamentals; vol 2: reactor design; vol 3: reactor analysis; vol 4: reactors of waste disposal and safeguards

CERN Document Server

2013-01-01

The Handbook of Nuclear Engineering is an authoritative compilation of information regarding methods and data used in all phases of nuclear engineering. Addressing nuclear engineers and scientists at all academic levels, this five volume set provides the latest findings in nuclear data and experimental techniques, reactor physics, kinetics, dynamics and control. Readers will also find a detailed description of data assimilation, model validation and calibration, sensitivity and uncertainty analysis, fuel management and cycles, nuclear reactor types and radiation shielding. A discussion of radioactive waste disposal, safeguards and non-proliferation, and fuel processing with partitioning and transmutation is also included. As nuclear technology becomes an important resource of non-polluting sustainable energy in the future, The Handbook of Nuclear Engineering is an excellent reference for practicing engineers, researchers and professionals.

4th ASEM Seminar on Knowledge Management to Enhance Nuclear Safety

International Nuclear Information System (INIS)

Castello, F.; Reyes, A. de los; Sobari, M. P. Mohd; Istiyanto, J. E.; Faross, P.; Delarosa, A.

2016-01-01

Full text: The 4th Asia-Europe Meeting (ASEM) Seminar on Nuclear Safety was convened in Madrid, Spain on 29th–30th October 2015, hosted by the Spanish Nuclear Safety Council. The seminar’s theme was “Knowledge management to enhance nuclear safety”, which aimed to continue discussing on nuclear safety to foster Asia-Europe capacity-building and cooperation in nuclear safety. The seminar was attended by representatives from national governments, nuclear regulators, energy companies, radiation protection and nuclear safety authorities, research institutes and universities. According to such model, proposed by the IAEA, the national capacity building requires an integrated approach based on four pillars: human resources development, education and training, knowledge management and knowledge networking. In this context, Nuclear Knowledge Management (KM) has become a high priority in many countries and international organizations and it has been taken into account to develop and implement specific strategies in ensuring safe and sustainable operation of nuclear facilities. At national level, a sustainable approach should include the necessary Nuclear Knowledge Management actions to ensure that every actor having a significant role in the national nuclear programmes infrastructure acquires, preserves and improves its corporate and individual knowledge. (author

Experimental Investigation of Burnup Credit for Safe Transport, Storage, and Disposal of Spent Nuclear Fuel

International Nuclear Information System (INIS)

Harms, Gary A.; Helmick, Paul H.; Ford, John T.; Walker, Sharon A.; Berry, Donald T.; Pickard, Paul S.

2004-01-01

This report describes criticality benchmark experiments containing rhodium that were conducted as part of a Department of Energy Nuclear Energy Research Initiative project. Rhodium is an important fission product absorber. A capability to perform critical experiments with low-enriched uranium fuel was established as part of the project. Ten critical experiments, some containing rhodium and others without, were conducted. The experiments were performed in such a way that the effects of the rhodium could be accurately isolated. The use of the experimental results to test neutronics codes is demonstrated by example for two Monte Carlo codes. These comparisons indicate that the codes predict the behavior of the rhodium in the critical systems within the experimental uncertainties. The results from this project, coupled with the results of follow-on experiments that investigate other fission products, can be used to quantify and reduce the conservatism of spent nuclear fuel safety analyses while still providing the necessary level of safety

Radiocarbon implications in the problem of nuclear fuel cycle radiation safety

International Nuclear Information System (INIS)

Malenchenko, A.F.; Mironov, V.P.

1979-01-01

The review is given of data on formation rate, environmental distribution and biological effects of natural and artificial carbon-14. 14 C release power is in the range from 20 to 2000 Ci/GW (el.) per year for operative and projected NPP and from 10 to 10 4 Ci/GW (el.) per year from nuclear fuel reprocessing plants depending upon the nitrogen content in a coolant and in fuel elements. Taking into account such injection into biosphere, 14 C is considered to be the main factor in radiation situation for the pupulation of the Northern hemisphere for the nearest decades. With regard for natural regularities revealed, the criteria have been formulated for the prediction of maximum permissible releases of radiocarbon from nuclear fuel plants

KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency.

Science.gov (United States)

Dhaliwal, Navroop K; Miri, Kamelia; Davidson, Scott; Tamim El Jarkass, Hala; Mitchell, Jennifer A

2018-04-10

Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency, KLF4 protein is exported from the nucleus causing rapid decline in Nanog and Klf4 transcription; as a result, KLF4 is the first pluripotency transcription factor removed from transcription-associated complexes during differentiation. KLF4 nuclear export requires ERK activation, and phosphorylation of KLF4 by ERK initiates interaction of KLF4 with nuclear export factor XPO1, leading to KLF4 export. Mutation of the ERK phosphorylation site in KLF4 (S132) blocks KLF4 nuclear export, the decline in Nanog, Klf4, and Sox2 mRNA, and differentiation. These findings demonstrate that relocalization of KLF4 to the cytoplasm is a critical first step in exit from the naive pluripotent state and initiation of ESC differentiation. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Experimental Study of Nuclear Security System Components for Achieving the Intrusion Process via Sensor's Network System

International Nuclear Information System (INIS)

EL-Kafas, A.A.

2011-01-01

Cluster sensors are one of nuclear security system components which are used to detect any intrusion process of the nuclear sites. In this work, an experimental measuring test for sensor performance and procedures are presented. Sensor performance testing performed to determine whether a particular sensor will be acceptable in a proposed design. We have access to a sensors test field in which the sensor of interest is already properly installed and the parameters have been set to optimal levels by preliminary testing. The glass-breakage (G.B) and open door (O.D) sensors construction, operation and design for the investigated nuclear site are explained. Intrusion tests were carried out inside the field areas of the sensors to evaluate the sensor performance during the intrusion process. Experimental trials were performed for achieving the intrusion process via sensor network system. The performance and intrusion senses of cluster sensors inside the internal zones was recorded and evaluated. The obtained results explained that the tested and experimented G.B sensors have a probability of detection P (D) value 65% founded, and 80% P (D) of Open-door sensor

The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome.

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Nowel Azzouz

Full Text Available BACKGROUND: Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4. It has been connected functionally in the nucleus to transcription by RNA polymerase II and in the cytoplasm to mRNA degradation. However, there has been no evidence so far that this complex is important for RNA degradation in the nucleus. METHODOLOGY/PRINCIPAL FINDINGS: In this work we point to a new role for the Ccr4-Not complex in nuclear RNA metabolism. We determine the importance of the Ccr4-Not complex for the levels of non-coding nuclear RNAs, such as mis-processed and polyadenylated snoRNAs, whose turnover depends upon the nuclear exosome and TRAMP. Consistently, mutation of both the Ccr4-Not complex and the nuclear exosome results in synthetic slow growth phenotypes. We demonstrate physical interactions between the Ccr4-Not complex and the exosome. First, Not5 co-purifies with the exosome. Second, several exosome subunits co-purify with the Ccr4-Not complex. Third, the Ccr4-Not complex is important for the integrity of large exosome-containing complexes. Finally, we reveal a connection between the Ccr4-Not complex and TRAMP through the association of the Mtr4 helicase with the Ccr4-Not complex and the importance of specific subunits of Ccr4-Not for the association of Mtr4 with the nuclear exosome subunit Rrp6. CONCLUSIONS/SIGNIFICANCE: We propose a model in which the Ccr4-Not complex may provide a platform contributing to dynamic interactions between the nuclear exosome and its co-factor TRAMP. Our findings connect for the first time the different players involved in nuclear and cytoplasmic RNA degradation.

The short term effects of Low-dose-rate Radiation on EL4 Lymphoma Cell

International Nuclear Information System (INIS)

Bong, Jin Jong; Kang, Yu Mi; Shin, Suk Chull; Choi, Moo Hyun; Choi, Seung Jin; Kim, Hee Sun; Lee, Kyung Mi

2012-01-01

To determine the biological effects of low-dose-rate radiation ( 137 Cs, 2.95 mGy/h) on EL4 lymphoma cells during 24 h, we investigated the expression of genes related to apoptosis, cell cycle arrest, DNA repair, iron transport, and ribonucleotide reductase. EL4 cells were continuously exposed to low-dose-rate radiation (total dose: 70.8 mGy) for 24 h. We analyzed cell proliferation and apoptosis by trypan blue exclusion and flow cytometry, gene expression by real-time PCR, and protein levels with the apoptosis ELISA kit. Apoptosis increased in the Low-dose-rate irradiated cells, but cell number did not differ between non- (Non-IR) and Low-dose-rate irradiated (LDR-IR) cells. In concordance with apoptotic rate, the transcriptional activity of ATM, p53, p21, and Parp was upregulated in the LDR-IR cells. Similarly, Phospho-p53 (Ser15), cleaved caspase 3 (Asp175), and cleaved Parp (Asp214) expression was upregulated in the LDR-IR cells. No difference was observed in the mRNA expression of DNA repair-related genes (Msh2, Msh3, Wrn, Lig4, Neil3, ERCC8, and ERCC6) between Non-IR and LDR-IR cells. Interestingly, the mRNA of Trfc was upregulated in the LDR-IR cells. Therefore, we suggest that short-term Low-dose-rate radiation activates apoptosis in EL4 lymphoma cells.

The short term effects of Low-dose-rate Radiation on EL4 Lymphoma Cell

Energy Technology Data Exchange (ETDEWEB)

Bong, Jin Jong; Kang, Yu Mi; Shin, Suk Chull; Choi, Moo Hyun; Choi, Seung Jin; Kim, Hee Sun [Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd, Seoul (Korea, Republic of); Lee, Kyung Mi [Global Research Lab, BAERI Institute, Dept. of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul (Korea, Republic of)

2012-06-15

To determine the biological effects of low-dose-rate radiation ({sup 137}Cs, 2.95 mGy/h) on EL4 lymphoma cells during 24 h, we investigated the expression of genes related to apoptosis, cell cycle arrest, DNA repair, iron transport, and ribonucleotide reductase. EL4 cells were continuously exposed to low-dose-rate radiation (total dose: 70.8 mGy) for 24 h. We analyzed cell proliferation and apoptosis by trypan blue exclusion and flow cytometry, gene expression by real-time PCR, and protein levels with the apoptosis ELISA kit. Apoptosis increased in the Low-dose-rate irradiated cells, but cell number did not differ between non- (Non-IR) and Low-dose-rate irradiated (LDR-IR) cells. In concordance with apoptotic rate, the transcriptional activity of ATM, p53, p21, and Parp was upregulated in the LDR-IR cells. Similarly, Phospho-p53 (Ser15), cleaved caspase 3 (Asp175), and cleaved Parp (Asp214) expression was upregulated in the LDR-IR cells. No difference was observed in the mRNA expression of DNA repair-related genes (Msh2, Msh3, Wrn, Lig4, Neil3, ERCC8, and ERCC6) between Non-IR and LDR-IR cells. Interestingly, the mRNA of Trfc was upregulated in the LDR-IR cells. Therefore, we suggest that short-term Low-dose-rate radiation activates apoptosis in EL4 lymphoma cells.

Computational Fluid Dynamics (CFD) for Nuclear Reactor Safety Applications - Workshop Proceedings, CFD4NRS-3 - Experimental Validation and Application of CFD and CMFD Codes to Nuclear Reactor Safety Issues

International Nuclear Information System (INIS)

2012-01-01

The purpose of the workshop was to provide a forum for numerical analysts and experimentalists to exchange information in the field of NRS-related activities relevant to CFD validation, with the objective of providing input to WGAMA CFD experts to create a practical, state-of-the-art, web-based assessment matrix on the use of CFD for NRS applications. The workshop included single-phase and multiphase CFD applications as well as new experimental techniques, including the following: Single-phase and two-phase CFD simulations with an emphasis on validation were sought in areas such as boiling flows, free-surface flows, direct contact condensation, and turbulent mixing. These should relate to NRS-relevant issues such as pressurized thermal shock, critical heat flux, pool heat exchangers, boron dilution, hydrogen distribution, and thermal striping. The use of systematic error quantification and Best Practice Guidelines (BPGs) was encouraged. Experiments providing data suitable for CFD validation-specifically in the area of NRS-including local measurement devices such as multi-sensor optical or electrical probes, Laser Doppler Velocimetry (LDV), hot-film/wire anemometry, Particle Image Velocimetry (PIV), Laser-Induced Fluorescence (LIF), and other innovative techniques. There were over 200 registered participants at the CFD4NRS-3 workshop. The program consisted of about 75 technical papers. Of these, 57 were oral presentations and 19 were posters. An additional 20 posters related to the OECD/NEA-sponsored CFD benchmark exercise on thermal fatigue in a T-Junction were presented. In addition, five keynote lectures were given by distinguished experts. This is about a 30 pc increase with respect to the previous XCFD4NRS workshop held in Grenoble in 2008, and a 70 pc increase compared to the first CFD4NRS workshop held in Garching in 2006. This confirms that there is a real and growing need for such workshops. The papers presented in the conference tackled different topics

Situación del sector nuclear en España

Directory of Open Access Journals (Sweden)

Antonio González Jiménez

2010-12-01

Full Text Available España comenzó a interesarse por la energía nuclear a finales de los años cuarenta. En el año 1964 se aprobó la Ley de Energía Nuclear, y en el año 1972 se desarrolló el Reglamento de Instalaciones Nucleares y Radiactivas. Las actividades de seguridad y regulación se encomendaron al Consejo de Seguridad Nuclear, creado en 1980, y la investigación y gestión de los residuos radiactivos a la Empresa Nacional de Residuos Radiactivos (ENRESA, creada en 1985. La estructura industrial nuclear en España comenzó a desarrollarse en los años sesenta, como consecuencia de la decisión de construir las centrales nucleares de José Cabrera, Santa María de Garoña y Vandellós I. En la siguiente etapa, en la década de los años setenta, se construyeron las centrales de Almaraz, Ascó y Cofrentes. Durante la tercera etapa, en la década de los años ochenta, se construyeron las centrales de Vandellós II y Trillo I.Actualmente, la industria nuclear española, experta y eficaz, es garantía de que la tecnología nuclear se conserva en España no solo para apoyar a las centrales nucleares en operación, sino para atender un mercado nuclear reactivado a nivel internacional. España dispone de la infraestructura necesaria, la capacidad técnica, los recursos financieros y la voluntad de las empresas en el empeño común de proporcionar a los españoles una energía eléctrica fiable, barata y sostenible, con respeto al medio ambiente y seguridad para los ciudadanos. La energía nuclear es, en definitiva, una pieza clave hoy y lo será en el futuro.

Efecto de la corriente pulsada en el proceso de soldadura GTAW en titanio 6Al4V con y sin metal de aporte

Directory of Open Access Journals (Sweden)

Cruz-González, Celso E.

2016-09-01

Full Text Available In this work the influence of the current is determined, the pulsed current with 20 and 50 Hz frequency in the mechanical properties, microstructure and wide lace GTAW (Gas Tungsten Arc Welding welding process 6AL4V titanium 1.6 mm thick. Full factorial design experiments with three replicates was perform. In the experimental design factors such as the use of input and frequency they were analyzed. Two metal levels for the contribution factor whose maximum level is the use of input and minimal unused filler were considered. In the case of the frequency, three levels were use as minimum is DC, 20 Hz is a central and 50 Hz as maximum level. Mechanical tensile tests performed 500 g Vickers microhardness and macro and micrographs of the welded joints. It was found that the mechanical properties of the affected joint are significantly (P En este trabajo se determinó la influencia de la corriente continua, la corriente pulsada con 20 y 50 Hz de frecuencia en las propiedades mecánicas, microestructura así como ancho del cordón del proceso de soldadura GTAW en titanio 6Al4V de 1,6 mm de espesor. Se realizó un diseño de experimentos factorial completo con tres réplicas. En el diseño de experimentos fueron analizados los factores, como el uso de aporte y frecuencia. Se consideraron dos niveles para el factor metal de aporte cuyo nivel máximo es el uso de aporte y el mínimo sin uso de aporte. Para el caso de la frecuencia se consideraron tres niveles, siendo el mínimo, corriente continua, 20 Hz como nivel medio y 50 Hz como nivel máximo. Se realizaron ensayos mecánicos de tensión, microdureza Vickers 500 g, así como macro y micrografías de las uniones soldadas. Se encontró que las propiedades mecánicas de la unión son afectadas significativamente (valor P < 0,05 con respecto a la frecuencia, tanto utilizando metal de aporte, o sin el uso de este. El ancho de cara y raíz disminuyó cuando ocurrió un cambio de corriente continua a 20 Hz

Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4

International Nuclear Information System (INIS)

Lorson, Monique A.; Dickson, Alexa M.; Shaw, Debra J.; Todd, Adrian G.; Young, Elizabeth C.; Morse, Robert; Wolstencroft, Catherine; Lorson, Christian L.; Young, Philip J.

2008-01-01

Gemin4 is a ubiquitously expressed multifunctional protein that is involved in U snRNP assembly, apoptosis, nuclear/cytoplasmic transportation, transcription, and RNAi pathways. Gemin4 is one of the core components of the Gemin-complex, which also contains survival motor neuron (SMN), the seven Gemin proteins (Gemin2-8), and Unrip. Mutations in the SMN1 gene cause the autosomal recessive disorder spinal muscular atrophy (SMA). Although the functions assigned to Gemin4 predominantly occur in the nucleus, the mechanisms that mediate the nuclear import of Gemin4 remain unclear. Here, using a novel panel of Gemin4 constructs we identify a canonical nuclear import sequence (NLS) in the N-terminus of Gemin4. The Gemin4 NLS is necessary and independently sufficient to mediate nuclear import of Gemin4. This is the first functional NLS identified within the SMN-Gemin complex

Experimental electromagnetic effects on the model organism Escherichia coli and the bacteriophage T4

Science.gov (United States)

Lisiewski, Darlene Mildred

This experimentally-based work was designed to answer the research question as to whether the phenomenon of nuclear magnetic resonance (NMR) can produce observable effects upon the bacterial virus activity of T4, with such activity demonstrated through the infection of its host bacterium Escherichia coli. The biological samples were placed for three hours within a coil antenna assembly propagating oscillating fields of radio frequency electromagnetic energy generated at the frequency of 5.6 MHz, and set at right angles within a magnetic field of 1450 gauss (recognizing such conditions are not set for the maximum effective resonance for hydrogen nuclei). The laboratory technique of plaque formation was the basis upon which the statistically tested data were compiled. Exposure of the bacterium alone exhibited an increase in viral activity over the control group (40--68% higher numbers of plaque formation), while exposure of T4 alone saw a decrease (approximately 23%) in infection rates. Depending on the protocol, placement of both T4 and E. coli into the coil assembly saw a decrease of either approximately 50% or 42% in infection rates. Future research must address identification of the effects being observed.

Welding with the TIG automatic process of the end fittings for the execution of the Embalse nuclear power plant fuel channel rechange; Soldadura con proceso TIG automatico de los accesorios extremos (end fitting) para la ejecucion de un recambio de canal de combustible en el reactor de la Central Nuclear Embalse

Energy Technology Data Exchange (ETDEWEB)

Suarez, P O

1991-12-31

The present work describes the methodology for the cutting of the existing welding and subsequent welding applied by the TIG process of the coupling composed by the shroud ring and the end fitting ring from one of Embalse nuclear power plant`s fuel channels. The replacement will be previously determined by the SLAR-ETTE mechanism where a displacement operated among the Gartner Spring rings, the pressure tubes are separated from the Calandria tubes. The welding to be carried out has the function of stamping the CO{sub 2} annular gas (thermal insulator) circulating between the pressure tube and the Calandria one during the functioning of the plant. (Author). [Espanol] El presente trabajo describe la metodologia de corte de la soldadura existente y la posterior soldadura aplicada mediante proceso TIG de la junta compuesta por el aro de fuelle y el anillo del `end fitting`, de uno de los canales de combustibles del reactor de la Central Nuclear Embalse. El reemplazo, se determinara previamente mediante el mecanismo de SLAR-ETTE con lo cual se observara el desplazamiento operado entre los anillos garten spring que separan los tubos de presion de los tubos de calandria. La soldadura a efectuar cumple la funcion de sellar el gas anular CO{sub 2} (aislante termico) circulante entre el tubo de presion y el tubo de calandria durante el funcionamiento de la planta. (Autor).

Individualismo y desconfianza en el trabajo asociativo de cadenas productivas de agroexportacion en el Valle del Mantaro, Junín, Perú

Directory of Open Access Journals (Sweden)

William Rodríguez Giráldez

2014-12-01

Full Text Available Objetivos: Determinar el individualismo y desconfianza en el trabajo asociativo de cadenas productivas de agroexportación en el Valle del Mantaro. Métodos: Investigación descriptiva, no experimental, de alcance transeccional correlacional. Fueron encuestados 383 productores agrícolas de las provincias que comprenden el Valle del Mantaro: Huancayo, Concepción, Jauja y Chupaca. Se utilizaron los estadísticos descriptivos, distribución de frecuencias, tablas de contingencia, y chi cuadrado para prueba de hipótesis. Resultados: En la dimensión individualismo: 72,23 % de productores manifestaron una actitud positiva hacia cadenas productivas; 87,2 % estimaron importante participar en reuniones; 88,5 % consideraron importante la capacitación en asociatividad y 86,2 % gustan trabajar conjuntamente con vecinos. Se deduce que el 83,53 % de ellos no tienen el rasgo de individualismo; por tanto, solo el 16,47 % tienen este rasgo y no influye negativamente en el trabajo asociativo en el Valle del Mantaro. En la dimensión desconfianza: 52 % de productores agrícolas manifestaron buena comunicación en la cadena productiva; 40 % aportaron entre 50 % y 100 % de costos de producción; 56 % podrían aportar entre 50 % y 100 % de costos de producción; 60 % señalaron que confían en empresas articuladoras y 60 % confían en colegas productores. Se deduce que, 53,6 % de estos productores no poseen el rasgo de desconfianza; mientras que 46,4 % si los tienen. Conclusiones: Solo 16,47 % de productores agrícolas tienen rasgos de individualismo y no influye negativamente en el trabajo asociativo; 46,4 % de estos productores tienen el rasgo de desconfianza y este valor sí influye negativamente en el trabajo asociativo en el valle.

The effects of tributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4

NARCIS (Netherlands)

Schmeits, P.J.M.; Kol, S.; Loveren, van H.; Peijnenburg, A.A.C.M.; Hendriksen, P.J.M.

2014-01-01

The main goal of this study was to assess the potential of the mouse thymoma EL-4 cell line in screening for chemical induced immunotoxicity. Therefore, EL-4 cells were exposed to two well-known immunotoxicants, organotin compound tributyltin oxide (TBTO, 0.5 and 1 µM for 3 or 6 h) and the mycotoxin

El deseo del bien o del bien aparente en ética a nicómaco iii.4

OpenAIRE

Gualdrón, Miguel

2010-01-01

La noción de “fin”, y el deseo de este fin, son cruciales dentro de la teoría aristotélica de la acción, en tanto sustentan no sólo la posibilidad misma de actuar, sino también la evaluación ética de la acción. El deseo de un fin en la acción es identificado en varios lugares de la obra de Aristóteles con el deseo del bien. En el capítulo 4 del libro III de la Ética a Nicómaco, Aristóteles plantea un problema en lo que concierne a este deseo, según el cual el deseo puede ser del bien en sí o ...

CULTIVO EXPERIMENTAL DE OCTOPUS MIMUS, GOULD 1852 EN EL PERÚ

Directory of Open Access Journals (Sweden)

Paul Baltazar

2014-06-01

Full Text Available Octopus mimus Gould, 1852 es un recurso bentónico muy importante en la pesquería artesanal peruana y de gran demanda en el mercado internacional. Actualmente no existen antecedentes sobre el cultivo de esta especie en el Pacifico Sudeste, salvo los realizados por Zuñiga (1995,1996 a, b y Baltazar et al. (1999. Las experiencias de cultivo se realizaron en las instalaciones del Centro de Acuicultura La Arena, Casma, Perú, empleándose tanques de fibra de vidrio y long-line en el mar. La alimentación fue a base de peces, crustáceos y moluscos, se ensayó con pienso húmedo que fue aceptado tras un periodo de inanición. La cópula se realizó con ejemplares mayores a 1,5 kg. Se observó diferencias en el crecimiento, en los tanques (185 y 369 g/mes fue mayor que en las líneas de cultivo (120,6 g/mes. Se obtuvieron paralarvas con una supervivencia máxima de 17 días a temperaturas de 21 a 22 oC, las que fueron alimentadas con nauplios de artemia (camarón de salmuera.

Product Manager C4ISR On-The-Move Experimentation

National Research Council Canada - National Science Library

Utroska, William; Langan, Russell; Amabile, Michael

2006-01-01

Product Manager C4ISR On-The-Move (PM C4ISR OTM) provides a relevant operational field experimentation venue for the purpose of assessing emerging technologies in a System-of- Systems (SoS) environment...

Experimental simulation study on hydraulic behavior of the main heat exchanger of Daqing 200 MW nuclear heating reactor

International Nuclear Information System (INIS)

Jiang Shengyao; Zhang Youjie; Jia Haijun; Bo Jinhai; Hong Liuming; Bo Hanliang; Liu Zhiyong

1997-07-01

The hydraulic behavior of the main heat exchanger of Daqing 200 MW nuclear heating reactor is studied through a 1:2.33 test model. The design and other feature of the test model is described. The experimental results show that the flow resistance coefficient of the heat exchanger becomes self-simulation when Reynolds number is greater than 5000. The value of flow resistance coefficient at self-simulation condition and the distribution of pressure drop in the heat exchanger are given through experiment. The option design to reduce flow resistance is proposed. The designed and experimental value for the flow resistance coefficient are in good agreement. The variation of system parameters during flow excursion was described. The experimental results are of great significant for the final design of the main heat exchanger of Daqing 200 MW nuclear heating reactor. (2 refs., 5 figs., 1 tab.)

Las tecnologías de organización de las TICS para el desarrollo (ICT4D), más allá del éxito y el fracaso : el caso de Infodesarrollo en Ecuador

OpenAIRE

Jiménez Becerra, Javier Andrés

2012-01-01

La Red Ecuatoriana de Información y Comunicación para el Desarrollo (Infodesarrollo), desde su inicio, fue considerada como una de las experiencias más exitosas de América Latina en el campo de las tecnologías de información y comunicación (TICS)1 para el desarrollo, así como un actor fundamental de las políticas públicas, en este tema, en Ecuador por 4 años (2005 -2008). Sin embargo, al finalizar el 2009 había desparecido del escenario de las políticas públicas en Ecuador y su continuidad...

Molecular pathways: the role of NR4A orphan nuclear receptors in cancer.

LENUS (Irish Health Repository)

Mohan, Helen M

2012-06-15

Nuclear receptors are of integral importance in carcinogenesis. Manipulation of classic ligand-activated nuclear receptors, such as estrogen receptor blockade in breast cancer, is an important established cancer therapy. Orphan nuclear receptors, such as nuclear family 4 subgroup A (NR4A) receptors, have no known natural ligand(s). These elusive receptors are increasingly recognized as molecular switches in cell survival and a molecular link between inflammation and cancer. NR4A receptors act as transcription factors, altering expression of downstream genes in apoptosis (Fas-ligand, TRAIL), proliferation, DNA repair, metabolism, cell migration, inflammation (interleukin-8), and angiogenesis (VEGF). NR4A receptors are modulated by multiple cell-signaling pathways, including protein kinase A\\/CREB, NF-κB, phosphoinositide 3-kinase\\/AKT, c-jun-NH(2)-kinase, Wnt, and mitogen-activated protein kinase pathways. NR4A receptor effects are context and tissue specific, influenced by their levels of expression, posttranslational modification, and interaction with other transcription factors (RXR, PPAR-Υ). The subcellular location of NR4A "nuclear receptors" is also important functionally; novel roles have been described in the cytoplasm where NR4A proteins act both indirectly and directly on the mitochondria to promote apoptosis via Bcl-2. NR4A receptors are implicated in a wide variety of malignancies, including breast, lung, colon, bladder, and prostate cancer; glioblastoma multiforme; sarcoma; and acute and\\/or chronic myeloid leukemia. NR4A receptors modulate response to conventional chemotherapy and represent an exciting frontier for chemotherapeutic intervention, as novel agents targeting NR4A receptors have now been developed. This review provides a concise clinical overview of current knowledge of NR4A signaling in cancer and the potential for therapeutic manipulation.

Desarrollo de un Banco de Pruebas Experimental mediante Control de Fuerza con Robot Industrial para el Análisis de la Respuesta Mecánica de Asientos de Coche

Directory of Open Access Journals (Sweden)

A. Valera

2009-04-01

Full Text Available Resumen: Este trabajo presenta el desarrollo de un banco de pruebas experimental para el análisis de la respuesta mecánica de los asientos de vehículos durante la entrada y salida de pasajeros. Para realizar este desarrollo, se consideran dos fases: la primera fase es la captura de datos, realizada mediante una manta sensorizada con una red de galgas de presión y un sistema de fotogrametría a fin de capturar el movimiento realizado por una persona al sentarse en el asiento de un automóvil. La segunda fase consiste en reproducir dicho movimiento de forma automática mediante un maniquí acoplado a un robot, controlando la fuerza que ejerce el maniquí sobre el asiento.El desarrollo debe permitir aplicar diferentes estrategias de control de fuerza con robots industriales, utilizando para ello una plataforma de prueba consistente en el robot IRB140 de ABB y un sensor de fuerza industrial JR3 de 6 grados de libertad. Como arquitectura de control, se presentan dos alternativas. La primera utiliza la aplicación software WebWare SDK de ABB. En la segunda solución, se ha modificado el controlador original S4CPlus del robot, proporcionando una arquitectura abierta de control que permite la implementación de nuevos algoritmos de control de movimiento y fuerza en el robot industrial.Con esta aplicación, se simula el proceso realizado por una persona al sentarse y levantarse del asiento de un automóvil, monitorizándose y controlándose la fuerza que ejerce un maniquí sobre un asiento para garantizar igualdad de condiciones con el caso real. El sistema desarrollado tiene numerosas aplicaciones prácticas, como por ejemplo la de poder analizar el desgaste que estos movimientos ocasionan en la tapicería de los asientos. Palabras clave: control de fuerza, control de robots, simulación de movimientos humanos, control por computador, aplicaciones digitales de computación, robots manipuladores

Nuclear information and knowledge. News from the INIS and Nuclear Knowledge Management Section. No. 4, September 2007

International Nuclear Information System (INIS)

Dyck, E.

2007-09-01

This bi-annual newsletter reports about the activities of the INIS and Nuclear Knowledge Management Section of the IAEA Department of Nuclear Energy. Issue no. 4 focuses on work of the Section in IAEA Member States. Strengthening relationships with Member States is exemplified in articles on visits of the Section Head, Mr. R. Workman, to Canada, China and India during spring and summer 2007. Key articles also cover the International Conference on Knowledge Management in Nuclear facilities, held at the IAEA on 18-21 June 2007, in particular the findings and recommendations from four conference sessions (Session 1: Knowledge Management (KM) for Safety and Regulations; Session 2: KM for Improved Performance and Economics; Session 3: KM for Innovation; and Session 4: Human Resources, Education, Training and Public Information) and an interview with the Chair of the conference, Mr. D.F. Torgerson, Senior Vice President and Chief Technology Officer at Atomic Energy of Canada Limited (AECL). Articles report on Nuclear Knowledge Management missions ('Assist Visits'), which constitute a direct service for IAEA Member States, that were undertaken to the Ignalina nuclear power plant, Lithuania, and two Canadian nuclear generating stations, i.e. Ontario Power Generation (OPG) Darlington and Bruce Power L.P. in 2007. Applying nuclear knowledge management (NKM) guidance in IAEA Member States is another example of work on site, and the newsletter reports about regional workshops in Karlsruhe, Germany, Obninsk, Russian Federation, and Tokyo, Japan. Guidance publications in NKM that have been developed through several technical meetings held at the IAEA will result in the following forthcoming publications: Nuclear Knowledge Management Objectives; Knowledge Management for Radioactive Waste Management; and Developing Portals for Nuclear Power Plants. The newsletter also reports about the Technical Meeting on the Development of New Nuclear Information Resources and their Integration

Tendencias de Tarificación en el Suministro de Energía Eléctrica

Directory of Open Access Journals (Sweden)

Hernando Durán Castro

2015-03-01

Full Text Available Se presenta un modelo de precios de energía eléctrica que permite a productores y consumidores operar como mercado. La demanda de energía eléctrica es variable en el tiempo y no es almacenable de un período a otro: se genera en el momento en que se demanda. Las tecnologías de generación (hidráulica, nuclear, térmica, etc. utilizan distintos combustibles y tienen costos diferentes de inversión en capacidad y de operación. El modelo minimiza la suma de ambos costos y garantiza que los productores obtengan un beneficio sobre la inversión en capacidad igual al WACC (Weighted Average Cost of Capital.

Protocol Additional to the agreement between the Republic of El Salvador and the International Atomic Energy Agency for the application of safeguards in connection with the Treaty for the Prohibition of Nuclear Weapons in Latin America and the Treaty on the Treaty on the Non-Proliferation of Nuclear Weapons

International Nuclear Information System (INIS)

2004-01-01

The text of the Protocol Additional to the Agreement between the Republic of El Salvador and the International Atomic Energy Agency in Connection with the Treaty for the Prohibition of Nuclear Weapons in Latin America and the Treaty on the Non-Proliferation of Nuclear Weapons is reproduced in the Annex to this document for the information of all Members. The Additional Protocol was approved by the Board of Governors on 23 September 2002. It was signed on 5 September 2003. Pursuant to Article 17 of the Additional Protocol, the Protocol entered into force on 24 May 2004, the date on which Agency received from El Salvador written notification that El Salvador's statutory and/or constitutional requirements for entry into force had been met

Isomer depletion as experimental evidence of nuclear excitation by electron capture

Science.gov (United States)

Chiara, C. J.; Carroll, J. J.; Carpenter, M. P.; Greene, J. P.; Hartley, D. J.; Janssens, R. V. F.; Lane, G. J.; Marsh, J. C.; Matters, D. A.; Polasik, M.; Rzadkiewicz, J.; Seweryniak, D.; Zhu, S.; Bottoni, S.; Hayes, A. B.; Karamian, S. A.

2018-02-01

The atomic nucleus and its electrons are often thought of as independent systems that are held together in the atom by their mutual attraction. Their interaction, however, leads to other important effects, such as providing an additional decay mode for excited nuclear states, whereby the nucleus releases energy by ejecting an atomic electron instead of by emitting a γ-ray. This ‘internal conversion’ has been known for about a hundred years and can be used to study nuclei and their interaction with their electrons. In the inverse process—nuclear excitation by electron capture (NEEC)—a free electron is captured into an atomic vacancy and can excite the nucleus to a higher-energy state, provided that the kinetic energy of the free electron plus the magnitude of its binding energy once captured matches the nuclear energy difference between the two states. NEEC was predicted in 1976 and has not hitherto been observed. Here we report evidence of NEEC in molybdenum-93 and determine the probability and cross-section for the process in a beam-based experimental scenario. Our results provide a standard for the assessment of theoretical models relevant to NEEC, which predict cross-sections that span many orders of magnitude. The greatest practical effect of the NEEC process may be on the survival of nuclei in stellar environments, in which it could excite isomers (that is, long-lived nuclear states) to shorter-lived states. Such excitations may reduce the abundance of the isotope after its production. This is an example of ‘isomer depletion’, which has been investigated previously through other reactions, but is used here to obtain evidence for NEEC.

Experimental nuclear level densities and γ-ray strength functions in Sc and V isotopes

International Nuclear Information System (INIS)

Larsen, A. C.; Guttormsen, M.; Ingebretsen, F.; Messelt, S.; Rekstad, J.; Siem, S.; Syed, N. U. H.; Chankova, R.; Loennroth, T.; Schiller, A.; Voinov, A.

2008-01-01

The nuclear physics group at the Oslo Cyclotron Laboratory has developed a method to extract nuclear level density and γ-ray strength function from first-generation γ-ray spectra. This method is applied on the nuclei 44,45 Sc and 50,51 V in this work. The experimental level densities of 44,45 Sc are compared to calculated level densities using a microscopic model based on BCS quasiparticles within the Nilsson level scheme. The γ-ray strength functions are also compared to theoretical expectations, showing an unexpected enhancement of the γ-ray strength for low γ energies (E γ ≤3 MeV) in all the isotopes studied here. The physical origin of this enhancement is not yet understood

Proceedings of the 4. Meeting of the nuclear magnetic resonance users; Anais do 4. Encontro de usuarios de ressonancia magnetica nuclear

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

This book shows the papers presented in the 4. Meeting of Nuclear Magnetic Resonance Users which took place in Rio de Janeiro, Brazil, 1993. The main topics discussed were: solid state NMR; structural and conformational structure determination by NMR; perspectives for NMR in Brazil; recent achievements in NMR

Control rod cluster drop time anomaly Guandong nuclear power station (Daya bay) and Electricite de France nuclear power stations (1450 MWe N4 Series)

International Nuclear Information System (INIS)

Olivera, J.J.; Naury, S.; Tricot, N.; Tran Dai, P.; Gama, J.M.

1996-01-01

The anomaly of control rod cluster drop time revealed at Guandong Nuclear Power Station in Daya Bay and in the Chooz B1 pilot unit for the N4 series, led to the replacement of the M1 type control rod cluster guide tubes with 1300 MWe PWR type guide tubes, adapted to the geometry of the Guandong reactors and the 1450 MWe reactors of the N4 series. The comparison of the drop times obtained with the 1300 MWe type control rod cluster guide 1300 MWe type control rod cluster guide tubes gave satisfactory results. These met the safety criterion for N4 series control rod cluster drop times (2.15 under hot shutdown conditions). The drop time tests which will be carried out in middle of and at the end of cycle 1 of Chooz B1 should make it possible to finally validate the solution already successfully implemented at Guandong. However, this anomaly has revealed the limits of representativeness of the experimental test loops with regard to the real reactor configuration. In view of this, it has been deemed necessary to ask Electricite de France to pursue its analysis both on the understanding of the phenomena which led to this anomaly and on the limits of the representativeness of the experimental test loops. (authors)

Zinc fingers 1, 2, 5 and 6 of transcriptional regulator, PRDM4, are required for its nuclear localisation

Energy Technology Data Exchange (ETDEWEB)

Tunbak, Hale, E-mail: h.tunbak@ucl.ac.uk [The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT (United Kingdom); Georgiou, Christiana, E-mail: christiana.georgiou.10@ucl.ac.uk [The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT (United Kingdom); Guan, Cui, E-mail: c.guan@qmul.ac.uk [School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom); Richardson, William David, E-mail: w.richardson@ucl.ac.uk [The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT (United Kingdom); Chittka, Alexandra, E-mail: a.chittka@ucl.ac.uk [The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT (United Kingdom)

2016-05-27

PRDM4 is a member of the PRDM family of transcriptional regulators which control various aspects of cellular differentiation and proliferation. PRDM proteins exert their biological functions both in the cytosol and the nucleus of cells. All PRDM proteins are characterised by the presence of two distinct structural motifs, the PR/SET domain and the zinc finger (ZF) motifs. We previously observed that deletion of all six zinc fingers found in PRDM4 leads to its accumulation in the cytosol, whereas overexpressed full length PRDM4 is found predominantly in the nucleus. Here, we investigated the requirements for single zinc fingers in the nuclear localisation of PRDM4. We demonstrate that ZF's 1, 2, 5 and 6 contribute to the accumulation of PRDM4 in the nucleus. Their effect is additive as deleting either ZF1-2 or ZF 5–6 redistributes PRDM4 protein from being almost exclusively nuclear to cytosolic and nuclear. We investigated the potential mechanism of nuclear shuttling of PRDM4 via the importin α/β-mediated pathway and find that PRDM4 nuclear targeting is independent of α/β-mediated nuclear import. -- Highlights: •Zinc fingers 1, 2, 5, and 6 are necessary for efficient nuclear localisation of PRDM4. •Zinc fingers 3 and 4 are dispensable for nuclear localisation of PRDM4. •Zinc knuckle is dispensable for nuclear localisation of PRDM4. •PRDM4 nuclear transport is independent of importin α/β-mediated pathway of nuclear import.

Fission 2009 4. International Workshop on Nuclear Fission and Fission Product Spectroscopy - Compilation of slides

International Nuclear Information System (INIS)

2009-01-01

This conference is dedicated to the last achievements in experimental and theoretical aspects of the nuclear fission process. The topics include: mass, charge and energy distribution, dynamical aspect of the fission process, nuclear data evaluation, quasi-fission and fission lifetime in super heavy elements, fission fragment spectroscopy, cross-section and fission barrier, and neutron and gamma emission. This document gathers the program of the conference and the slides of the presentations

Pérdida de empleo en el sector minero de la Comarca del Bierzo: estrategias familiares

OpenAIRE

Gago Fernández, Inés

2016-01-01

El tema de estudio de este trabajo fin de máster es analizar la dinámica de la familia nuclear en el contexto actual de crisis económica y social existente en nuestro país, en la repercusión del desempleo en la familia nuclear. El documento final que

Nuclear receptor 4A (NR4A) family - orphans no more.

Science.gov (United States)

Safe, Stephen; Jin, Un-Ho; Morpurgo, Benjamin; Abudayyeh, Ala; Singh, Mandip; Tjalkens, Ronald B

2016-03-01

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes induced by multiple stressors, and the NR4A receptors play an important role in maintaining cellular homeostasis and disease. There is increasing evidence for the role of these receptors in metabolic, cardiovascular and neurological functions and also in inflammation and inflammatory diseases and in immune functions and cancer. Despite the similarities of NR4A1, NR4A2 and NR4A3 and their interactions with common cis-genomic elements, they exhibit unique activities and cell-/tissue-specific functions. Although endogenous ligands for NR4A receptors have not been identified, there is increasing evidence that structurally-diverse synthetic molecules can directly interact with the ligand binding domain of NR4A1 and act as agonists or antagonists, and ligands for NR4A2 and NR4A3 have also been identified. Since NR4A receptors are key factors in multiple diseases, there are opportunities for the future development of NR4A ligands for clinical applications in treating multiple health problems including metabolic, neurologic and cardiovascular diseases, other inflammatory conditions, and cancer. Copyright © 2015 Elsevier Ltd. All rights reserved.

4. Nuclear power plant component failures

International Nuclear Information System (INIS)

1990-01-01

Nuclear power plant component failures are dealt with in relation to reliability in nuclear power engineering. The topics treated include classification of failures, analysis of their causes and impacts, nuclear power plant failure data acquisition and processing, interdependent failures, and human factor reliability in nuclear power engineering. (P.A.). 8 figs., 7 tabs., 23 refs

COMUNICACION PRELIMINAR SOBRE EL EFECTO DEL MICROELEMENTO MOLIBDENO EN EL RINDE DEL ALGODONERO

Directory of Open Access Journals (Sweden)

Isidoro Mogilner

1960-01-01

Full Text Available Se trataron semillas de algodonero de la variedad Stoneville 2B, con soluciones de distinta concentración de (NH42 Mo O4, durante 24 horas, a dos temperaturas distintas. Tratadas las semillas se sembraron dos ensayos, cada uno con las 8 variantes y utilizando dos testigos (H20 destilada para la variante 1; Y H20 corriente para la variante 2.Los dos ensayos ocuparon un terreno contiguo y similar, cuyo suelo es arcilloso, relativamente pobre en Ca, muy pobre en P, y de una reacción ácida (pH de 5,09 a 5,85. Para los dos ensayos se utilizó la misma disposición experimental, con la diferencia de que el segundo ensayo se sembró con previo abonado de una mezcla comercial (Amino-Phos-Ko, 10-20-20; la siembra se efectuó en el mismo día. Se alcanzó a realizar tres cosechas. Los resultados obtenidos en el segundo ensayo (con abono no fueron tan válidos como en el primero (sin abono, porque no pudimos saber si el abono agregado contenía como impurezas el Mo, presente en muchas fuentes del fósforo utilizados en la preparación de abonos (ej.: fosforita. Del primer ensayo, en suelo no abonado, se extrajeron como conclusiones: 1 que en tipos de suelos como en el que se realizaron los ensayos, el suministro de dosis adecuadas de molibdeno incide satisfactoriamente sobre un aumento de los rindes del algodonero, tanto como de 300 Kgfha; 2 que aunque no podemos decir exactamente cual es la dosis óptima para el tratamiento de la semilla antes de la siembra, parecería que se encuentra entre 0,05 % y 0,02 % de molibdato de amonio; 3 que la temperatura a la que se realice el tratamiento de la semila, parece tener importancia; y en los ensayos realizados fueron superiores los rindes con el tratamiento a 30°C, que a 21°C.

Agreement of 30 January 1992 between the Government of the Democratic People's Republic of Korea and the International Atomic Energy Agency for the Application of Safeguards in connection with the Treaty on the Nonproliferation of Nuclear Weapons; Acuerdo De 30 De Enero De 1992 Entre El Gobierno De La Republica Popular Democratica De Corea Y El Organismo Internacional De Enercia Atomica Para La Aplicacion De Salvaguardias En Relacion Con El Tratado Sobre La No Proliferacion De Las Armas Nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-05-15

The text of the Agreement between the Government of the Democratic People's Republic of Korea and the International Atomic Energy Agency for the application of safeguards in connection with the Treaty on the Non-Proliferation of Nuclear Weapons is reproduced in this document for the information of all Members. The Agreement was approved by the Agency's Board of Governors on 12 September 1991 and signed in Vienna on 30 January 1992. The Agreement entered into force, pursuant to Article 25, on 10 April 1992 [Spanish] El texto del Acuerdo entre el Gobierno de la Republica Popular Democratic-a de Corea y el Organismo Internacional de Energia Atomica para la aplica cion de salvaguardias en relacion con el Tratado sobre la no proliferacion de las armas nuclearese reproduce en este documento para informacion de to dos los Estados Miembros. El Acuerdo fue aprobado por la Junta de Gobernado res del Organismo el 12 de septiembre de 1991 y firmado en Viena el 30 de ene ro de 1992.

[Establishment of EL4 tumor-bearing mouse models and investigation on immunological mechanisms of anti-tumor effect of melphalan].

Science.gov (United States)

Li, Mo-lin; Li, Chuan-gang; Shu, Xiao-hong; Jia, Yu-jie; Qin, Zhi-hai

2006-03-01

To establish mouse lymphoma EL4 tumor-bearing mouse models in wild type C57BL/6 mice and nude C57BL/6 mice respectively, and to further investigate the immunological mechanisms of anti-tumor effect of melphalan. Mouse lymphoma EL4 cells were inoculated subcutaneously into wild type C57BL/6 mice (immune-competent mice). Twelve days later, melphalan of different doses were administered intraperitoneally to treat these wild type C57BL/6 tuomr-bearing mice. Tumor sizes were observed and recorded subsequently to find out the minimal dose of melphalan that could cure the tuomr-bearing mice. Then the same amount of EL4 tumor cells were inoculated subcutaneously into wild type C57BL/6 mice and nude C57BL/6 mice (T cell-deficient mice) simultaneously, which had the same genetic background of C57BL/6. Twelve days later, melphalan of the minimal dose was given intraperitoneally to treat both the wild type and nude C57BL/6 tuomr-bearing mice. Tumor sizes were observed and recorded in these two different types of mice subsequently. A single dose of melphalan (7.5 mg/kg) could cure EL4 tumor-bearing wild type C57BL/6 mice, but could not induce tumor regression in EL4 tumor-bearing nude C57BL/6 mice. A single dose of melphalan has obvious anti-tumor effect on mouse lymphoma EL4 tumor-bearing wild type C57BL/6mice, which requires the involvement of T lymphocytes in the host probably related to their killing functions.

Experimental overview and challenge in strangeness nuclear physics — strangeness in the past and coming decades

International Nuclear Information System (INIS)

Imai, Kenichi

2010-01-01

A great progress has been made in strangeness nuclear physics in the past decade. Examples are; 1) The "hyperfine" structure of hypernuclei were measured with the Hyperball, and ΛN spin dependent interactions in p-shell hypernuclei were determined. 2) The "complete measurements" of the weak decay of hypernuclei were made and the np ratio puzzle in the non-mesonic decay was solved. 3) The discovery of a clean event of "Lambpha" and determination of its binding energy concluded that the Λ-Λ interaction is weak attractive. However, we still have important questions to be answered in this field, especially in relation with QCD and nuclear physics. For the future strangeness nuclear physics, we have and will have facilities such as JLab, SPring-8, Daphne, J-PARC, FAIR. We discuss experimental challenges in the strangeness nuclear physics and related fields in the next decade. (author)

Comportamiento eléctrico del compuesto Bi5FeTi3O15 y de sus soluciones sólidas con CaBi4Ti4O15

Directory of Open Access Journals (Sweden)

Durán, P.

1999-12-01

Full Text Available Bi5FeTi3O15 (BiFT compound has been prepared by solid state reaction between the corresponding oxides. Its crystalline structure has been established by X ray Diffraction, (XRD. Ceramic samples with apparent density > 95% Dth have been sintered. On these samples, electrical conductivity and Curie temperature have been measured. Solid solutions of Bi5FeTi3O15 (BiFT and CaBi4Ti4O15 (CBiT have been prepared. On poled samples of these solid solutions, piezoelectric parameters have been established. The BiFT compound shows electrical conductivity values very similar to those of the Bi4Ti3O12 (BiT compound. The electrical conductivity of solid solutions is a function of CBiT amount. A possible electrical conductivity mechanism which is different of that accepted for the BiT compound is discussed.Se ha preparado Bi5FeTi3O15 (BiFT por reacción en estado sólido de los óxidos correspondientes. Se ha determinado su estructura cristalina por Difracción de Rayos X (DRX. Se han preparado compactos sinterizados con densidades superiores al 95%. Se ha determinado su temperatura de Curie, y la conductividad eléctrica entre 150 y 850ºC. Se han preparado soluciones sólidas de Bi5FeTi3O15 con CaBi4Ti4O15, (CBiT y se han determinado los mismos parámetros de temperatura de Curie y de conductividad para ellas. En las soluciones sólidas se han determinado los parámetros Piezoeléctricos de muestras polarizadas Debe destacarse que el compuesto Bi5FeTi3O15 presenta unos valores de conducción eléctrica más próximos a los correspondientes al Bi4Ti3O12 (BiT que a los de los compuestos MeBi4Ti4O15. La conductividad eléctrica de las soluciones sólidas varía con el contenido de CBiT. Se discute la posible existencia de un modelo de conducción eléctrica que difiere del aceptado hasta el momento para el BiT, basado en los defectos localizados en las capas Bi2O2 2-.

Nuclear safety and radiation protection report of the nuclear facility of Brennilis - 2011

International Nuclear Information System (INIS)

2012-01-01

This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the partially dismantled facilities of the Monts d'Arree (EL4-D or Brennilis) site (INB 162 (FR)). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2011, are reported as well as the radioactive effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

Nuclear safety and radiation protection report of the nuclear facilities of Brennilis - 2010

International Nuclear Information System (INIS)

2011-06-01

This safety report was established under the article 21 of the French law no. 2006-686 of June 13, 2006 relative to nuclear safety and information transparency. It presents, first, the partially dismantled facilities of the Monts d'Arree (EL4-D or Brennilis) site (INB 162 (FR)). Then, the nuclear safety and radiation protection measures taken regarding the facilities are reviewed: nuclear safety definition, radiation protection of intervening parties, safety and radiation protection improvement paths, crisis management, external and internal controls, technical situation of facilities, administrative procedures in progress. The incidents and accidents which occurred in 2010, are reported as well as the radioactive effluents discharge in the environment. Finally, The radioactive materials and wastes generated by the facilities are presented and sorted by type of waste, quantities and type of conditioning. Actions in favour of transparency and public information are presented as well. The document concludes with a glossary and a list of recommendations from the Committees for health, safety and working conditions. (J.S.)

Updating and using the international non-neutron experimental nuclear data base in ''Generalized EXFOR'' format

International Nuclear Information System (INIS)

Zhuravleva, G.M.; Chukreev, F.E.

1985-10-01

A software system for the automatic preparation of non-formalized textual information for the international exchange of nuclear data in the ''Generalized Exchange Format (EXFOR)'' is described. The ''Generalized EXFOR'' format is briefly outlined and data are given on the size of the international non-neutron experimental data base in this format. (author)

INFLUENCIA DE LAS CONDICIONES FISICOQUÍMICAS DEL SEDIMENTO Y LA INTERFASE AGUA-SEDIMENTO EN LA TRANSFERENCIA EXPERIMENTAL DEL O,O-DIETIL O?- 3,5,6 TRICLORO-2-PIRIDINIL FOSFOROTIATO (CLORPIRIFOS Y EL 3,5,6 TRICLORO-2-PIRIDINOL (TCP, EN EL EMBALSE RIOGRANDE II

Directory of Open Access Journals (Sweden)

Diana María Agudelo

2013-12-01

Full Text Available En esta investigación experimental se evaluó la influencia de algunas variables fisicoquímicas de sedimentos procedentes del embalse Riogrande II y de la interfase agua-sedimento en la transferencia de Clorpirifos y TCP. El análisis de clorpirifos y TCP en sedimentos y agua se realizó por extracción en fase sólida. Las muestras fueron detectadas por cromatografía de gases acoplada a espectrometría de masas (Trace GC Ultra MS 2030-Thermo Scientific. Se evidenció una fuerte adsorción de ambos compuestos en los sedimentos, dado el alto contenido de arcillas y de carbono orgánico, lo cual limitó su movilidad hacia la interfase. La interfase agua-sedimento se caracterizó por una condición de hipoxia durante toda la fase experimental, mientras que la conductividad eléctrica aumento en el tiempo. Se determinó que un pH neutro o ligeramente alcalino favoreció el aumento de la concentración de clorpirifos en la interfase agua-sedimento, lo cual sugiere un incremento de su transferencia desde el sedimento a la interfase, mientras que un pH ligeramente ácido favorece la transformación del compuesto parental en el sedimento.

Inteligencia emocional: Su relación con el rendimiento académico en preadolescentes de la Escuela 4 de Abril, de Io ciclo, Angola

OpenAIRE

María Domingas Cassinda Vissupe; António Chingombe Jacob; Lisandra Angulo Gallo; Vivian M. Guerra Morales

2017-01-01

La investigación fue realizada con el objetivo de caracterizar la expresión de la inteligencia emocional (en lo sucesivo IE) en preadolescentes con bajo rendimiento académico, de la escuela “4 de Abril”, de la provincia de Huambo, Angola. Se asumió un paradigma mixto, predominantemente cuantitativo, con un diseño no experimental, transversal y un tipo de estudio exploratorio. Se efectuó un muestreo no probabilístico, se seleccionó una muestra de 60 preadolescentes, 30 con bajo rendimiento (en...

Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells.

Science.gov (United States)

Gause, K C; Homma, M K; Licciardi, K A; Seger, R; Ahn, N G; Peterson, M J; Krebs, E G; Meier, K E

1993-08-05

Phorbol ester-sensitive and -resistant EL4 thymoma cell lines differ in their ability to activate mitogen-activated protein kinase (MAPK) in response to phorbol ester. Treatment of wild-type EL4 cells with phorbol ester results in the rapid activations of MAPK and pp90rsk kinase, a substrate for MAPK, while neither kinase is activated in response to phorbol ester in variant EL4 cells. This study examines the activation of MAPK kinase (MAPKK), an activator of MAPK, in wild-type and variant EL4 cells. Phosphorylation of a 40-kDa substrate, identified as MAPK, was observed following in vitro phosphorylation reactions using cytosolic extracts or Mono Q column fractions prepared from phorbol ester-treated wild-type EL4 cells. MAPKK activity coeluted with a portion of the inactive MAPK upon Mono Q anion-exchange chromatography, permitting detection of the MAPKK activity in fractions containing both kinases. This MAPKK activity was present in phorbol ester-treated wild-type cells, but not in phorbol ester-treated variant cells or in untreated wild-type or variant cells. The MAPKK from wild-type cells was able to activate MAPK prepared from either wild-type or variant cells. MAPKK activity could be stimulated in both wildtype and variant EL4 cells in response to treatment of cells with okadaic acid. These results indicate that the failure of variant EL4 cells to activate MAP kinase in response to phorbol ester is due to a failure to activate MAPKK. Therefore, the step that confers phorbol ester resistance to variant EL4 cells lies between the activation of protein kinase C and the activation of MAPKK.

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.

Science.gov (United States)

Smith, Kate M; Di Antonio, Veronica; Bellucci, Luca; Thomas, David R; Caporuscio, Fabiana; Ciccarese, Francesco; Ghassabian, Hanieh; Wagstaff, Kylie M; Forwood, Jade K; Jans, David A; Palù, Giorgio; Alvisi, Gualtiero

2018-08-01

Nuclear import involves the recognition by importin (IMP) superfamily members of nuclear localization signals (NLSs) within protein cargoes destined for the nucleus, the best understood being recognition of classical NLSs (cNLSs) by the IMPα/β1 heterodimer. Although the cNLS consensus [K-(K/R)-X-(K/R) for positions P2-P5] is generally accepted, recent studies indicated that the contribution made by different residues at the P4 position can vary. Here, we apply a combination of microscopy, molecular dynamics, crystallography, in vitro binding, and bioinformatics approaches to show that the nature of residues at P4 indeed modulates cNLS function in the context of a prototypical Simian Virus 40 large tumor antigen-derived cNLS (KKRK, P2-5). Indeed, all hydrophobic substitutions in place of R impaired binding to IMPα and nuclear targeting, with the largest effect exerted by a G residue at P4. Substitution of R with neutral hydrophobic residues caused the loss of electrostatic and van der Waals interactions between the P4 residue side chains and IMPα. Detailed bioinformatics analysis confirmed the importance of the P4 residue for cNLS function across the human proteome, with specific residues such as G being associated with low activity. Furthermore, we validate our findings for two additional cNLSs from human cytomegalovirus (HCMV) DNA polymerase catalytic subunit UL54 and processivity factor UL44, where a G residue at P4 results in a 2-3-fold decrease in NLS activity. Our results thus showed that the P4 residue makes a hitherto poorly appreciated contribution to nuclear import efficiency, which is essential to determining the precise nuclear levels of cargoes. Copyright © 2018 Elsevier B.V. All rights reserved.

Advanced Nuclear Magnetic Resonance

OpenAIRE

Alonso, Diego A.

2014-01-01

Transparencias en inglés de la asignatura "Resonancia Magnética Nuclear Avanzada" (Advanced Nuclear Magnetic Resonance) (36643) que se imparte en el Máster de Química Médica como asignatura optativa de 3 créditos ECTS. En esta asignatura se completa el estudio iniciado en la asignatura de quinto curso de la licenciatura en Química "Determinación estructural" (7448) y en la del Grado de Química de tercer curso "Determinación estructural de los compuestos orgánicos" (26030) en lo referente a té...

From 3D to 4D seismic tomography at El Hierro Island (Canary Islands, Spain)

Science.gov (United States)

Garcia-Yeguas, A.; Koulakov, I.; Jakovlev, A.; Ibáñez, J. M.

2012-04-01

In this work we are going to show the advantages of a dynamic tomography 4D, versus a static image 3D related with a volcanic reactivation and eruption at El Hierro island (Canary Islands, Spain). In this process a high number of earthquakes before and during the eruptive processes have been registered. We are going to show a 3D image as an average of the velocity structure and then the characteristics and physical properties on the medium, including the presence or not of magma. This image will be complemented with its evolution along the time, observing its volcanic dynamic and its influence over the medium properties, including its power as an important element on early warnings protocols. After more than forty years of quiet at Canary Islands, since 1971 with Teneguía eruption at La Palma Island, and more than 200 years on El Hierro Island (The last eruption known at El Hierro took place in 1793, volcán de Lomo Negro), on 19th July on 2011 the Spanish seismic national network, administered by IGN (Instituto Geográfico Nacional), detected an increase of local seismic activity below El Hierro island (Canary Islands, Spain). Since this moment an intense swarm took place, with more than 11000 events, until 11th December, with magnitudes (MLg) from 0.2 to 4.4. In this period two eruptive processes have been declared in front of the South coast of El Hierro island, and they have not finished yet. This seismic swarm has allowed carrying out a 3D seismic tomography, using P and S waves traveltimes. It has showed a low velocity from the North to the South. On the other hand, we have performed a 4D seismic tomography, taking the events occurred at different intervals of time. We can observe the evolution of the negative anomaly along the time, from the North to the South, where has taken place La Restinga submarine eruption. 4D seismic tomography is an innovative and powerful tool able to show the evolution in time of a volcanic process.

4+D digital engineering for advanced nuclear energy systems

International Nuclear Information System (INIS)

Jeong, S. G.; Suh, K. Y.; Nam, S. K.

2007-01-01

Nuclear power plants (NPPs) require massive quantity of data during the design, construction, operation, maintenance and decommissioning stages because of their special features like size, cost, radioactivity, and so forth. The system engineering thus calls for a fully automated way of managing the information flow spanning their life cycle. In line with practice in disciplines of naval architecture, aerospace engineering, and automotive manufacturing, the paper proposes total digital systems engineering based on three-dimensional (3D) computer-aided design (CAD) models. The signature in the proposal lies with the four-plus-dimensional (4 + D) Technology T M, a critical know-how for digital management. The so-called OPIUM (Optimized Plant Integrated Ubiquitous Management) features a 4 + D Technology T M for nuclear energy systems engineering. The technology proposed in the 3D space and time plus cost coordinates, i.e. 4 + D, is the backbone of digital engineering in the nuclear systems design and management. Based on an integrated 3D configuration management system, OPIUM consists of solutions NOTUS (Nuclear Optimization Technique Ubiquitous System), VENUS (Virtual Engineering Nuclear Ubiquitous System), INUUS (Informatics Nuclear Utilities Ubiquitous System), JANUS (Junctional Analysis Numerical Ubiquitous System) and EURUS (Electronic Unit Research Ubiquitous System). These solutions will help initial simulation capability for NPPs to supply the crucial information. NOTUS contributes to reducing the construction cost of the NPPs by optimizing the component manufacturing procedure and the plant construction process. Planning and scheduling construction projects can thus benefit greatly by integrating traditional management techniques with digital process simulation visualization. The 3D visualization of construction processes and the resulting products intrinsically afford most of the advantages realized by incorporating a purely schedule level detail based the 4

Science, society, and America's nuclear waste: Unit 4, The waste management system

International Nuclear Information System (INIS)

1992-01-01

This is unit 4 (The Waste Management System) in a four-unit secondary curriculum. It is intended to provide information about scientific and societal issues related to the management of spent nuclear fuel from generation of electricity at nuclear powerplants and high-level radioactive waste from US national defense activities. The curriculum, supporting classroom activities, and teaching materials present a brief discussion of energy and electricity generation, including that produced at nuclear powerplants; information on sources, amounts, location, and characteristics of spent nuclear fuel and high-level radioactive waste; sources, types and effects of radiation; US policy for managing and disposing of spent nuclear fuel and high-level radioactive waste and what other countries are doing; and the components of the nuclear waste management system

Gratitud en el aula (Gratitude in the Classroom

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Jose Miguel Garcia-Ramirez

2015-01-01

Full Text Available Resumen La gratitud es una fortaleza psicológica que facilita la adquisición y construcción social del conocimiento, infiriendo intencionalidad y búsqueda del beneficio compartido como intercambio recíproco guiado por las emociones y el afecto. Con esta investigación se demuestra que la acción de mostrar gratitud influye positivamente en el rendimiento académico. Método: Estudio exploratorio realizado durante el primer semestre del curso académico 2013-14 y el primer semestre del curso académico 2014-15 en Trent University (Canadá. Ciento cuarenta y cinco estudiantes de Estudios Hispánicos fueron adscritos al Grupo Experimental o al Grupo Control. Al grupo experimental se le aplicó un programa de agradecimiento simple; para el análisis del impacto del programa fueron utilizadas dos pruebas objetivas (pre y post de rendimiento académico. Resultados: El análisis estadístico muestra que existen diferencias significativas entre los resultados obtenidos por el Grupo Control y el Grupo Experimental, cuyos integrantes obtuvieron un mejor rendimiento que los del grupo control. Conclusiones: La gratitud mejora el rendimiento académico en el aprendizaje de las lenguas y ayuda a consolidar una educación humanística. Abstract Gratitude is a psychological strength that facilitates acquisition and social construction of knowledge, inferring intent and a search for shared benefit as a reciprocal exchange guided by emotions and affection. This research study shows that the act of expressing gratitude has a positive influence on academic achievement. Method: An exploratory study conducted during the first semester of the 2013-14 academic year and the first semester of the 2014-15 academic year at Trent University (Canada. The participants were 145 students of Hispanic Studies, randomly assigned to the experimental group or the control group. The experimental group received a simple appreciation program; the instruments used were two

Investigation of thermodynamic cycle for generic 1200 MW{sub el} pressure channel reactor with nuclear steam superheat

Energy Technology Data Exchange (ETDEWEB)

Vincze, A.; Sidawi, K.; Abdullah, R.; Baldock, M.; Saltanov, E.; Pioro, I., E-mail: andrei.vincze@uoit.net, E-mail: khalil.sidawi@uoit.net, E-mail: rand.abdullah@uoit.net, E-mail: matthew.baldock@uoit.net, E-mail: eugene.saltanov@uoit.ca, E-mail: igor.pioro@uoit.ca [Univ. of Ontario Inst. of Tech., Oshawa, ON (Canada)

2014-07-01

Current Nuclear Power Plants (NPPs) play a significant role in energy production around the world. All NPPs operating today employ a Rankine steam cycle for the conversion of thermal power to electricity. This paper will examine the steam cycle arrangement an experimental pressure channel reactor using Nuclear Steam Superheat (NSS) and compare it to two advanced reactor designs, the Advanced CANDU Reactor 1000 (ACR-1000) and the Advanced Boiling Water Reactor (ABWR) designs. The thermodynamic cycle layout and thermal efficiencies of the three reactor types will be discussed. (author)

Una alternativa para el diseño de experimentos con grupos intactos

Directory of Open Access Journals (Sweden)

Raúl Hernández-Heredia

2017-11-01

Full Text Available Se ofrece una variante de la proyección del trabajo experimental con grupos docentes intactos. Sobre la base de seis grupos intactos no equivalentes, se conforma un grupo experimental y otro de control, a partir de la técnica de pareamiento grupal. El pareamiento se desarrolló tomando como punto de partida un diagnóstico inicial de tres capacidades físicas básicas de trascendencia para el entrenamiento deportivo. Como resultado se obtuvieron dos grupos equivalentes (experimental y control y se garantizó el control de variables ajenas, imprescindible para minimizar el nivel de incertidumbre en el trabajo experimental.

NR4A nuclear receptors are orphans but not lonesome

NARCIS (Netherlands)

Kurakula, Kondababu; Koenis, Duco S.; van Tiel, Claudia M.; de Vries, Carlie J. M.

2014-01-01

The NR4A subfamily of nuclear receptors consists of three mammalian members: Nur77, Nurr1, and NOR-1. The NR4A receptors are involved in essential physiological processes such as adaptive and innate immune cell differentiation, metabolism and brain function. They act as transcription factors that

Nuclear Nox4-Derived Reactive Oxygen Species in Myelodysplastic Syndromes

Directory of Open Access Journals (Sweden)

Marianna Guida

2014-01-01

Full Text Available A role for intracellular ROS production has been recently implicated in the pathogenesis and progression of a wide variety of neoplasias. ROS sources, such as NAD(PH oxidase (Nox complexes, are frequently activated in AML (acute myeloid leukemia blasts and strongly contribute to their proliferation, survival, and drug resistance. Myelodysplastic syndromes (MDS comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an increased propensity to develop AML. The molecular basis for MDS progression is unknown, but a key element in MDS disease progression is the genomic instability. NADPH oxidases are now recognized to have specific subcellular localizations, this targeting to specific compartments for localized ROS production. Local Nox-dependent ROS production in the nucleus may contribute to the regulation of redox-dependent cell growth, differentiation, senescence, DNA damage, and apoptosis. We observed that Nox1, 2, and 4 isoforms and p22phox and Rac1 subunits are expressed in MDS/AML cell lines and MDS samples, also in the nuclear fractions. Interestingly, Nox4 interacts with ERK and Akt1 within nuclear speckle domain, suggesting that Nox4 could be involved in regulating gene expression and splicing factor activity. These data contribute to the elucidation of the molecular mechanisms used by nuclear ROS to drive MDS evolution to AML.

Responsabilidad social desde el enfoque de la gestión pública en el sector universitario

OpenAIRE

Jesús Salom; Cira de Pelekais; María Guadalupe Núñez

2011-01-01

El propósito de esta investigación fue desarrollar una serie de lineamientos estratégicos para el fortalecimiento de la responsabilidad social desde el enfoque de la gestión pública en el sector universitario. El estudio se ubicó como analítico- descriptivo y de campo, con un diseño no experimental y transeccional. La población estuvo conformada por 5 Decanos y 34 Directores de Escuelas en el sector universitario. Se utilizó la técnica de observación por encuesta, y como instrumento, el cuest...