WorldWideScience

Sample records for european clinical research

  1. [ECRIN (European clinical research infrastructures network), a pan-European infrastructure for clinical research].

    Science.gov (United States)

    Demotes-Mainard, Jacques

    2010-12-01

    Clinical research plays a key role both in the development of innovative health products and in the optimisation of medical strategies, leading to evidence-based practice and healthcare cost containment. ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients, and unlocking latent scientific providing services to multinational. Servicing of multinational trials started during the preparatory phase, and ECRIN has applied for ERIC status in 2011. In parallel, ECRIN has also proposed an FP7 integrating activity project to further develop, upgrade and expand the ECRIN infrastructure built up during the past FP6 and FP7 projects, facilitating an efficient organization of clinical research in Europe, with ECRIN developing generic tools and providing generic services for multinational studies, and supporting the construction of pan-European disease-oriented networks that will in turn act as ECRIN users. This organization will improve Europe's attractiveness for industry trials, boost its scientific competitiveness, and result in better healthcare for European citizens. The three medical areas supported in this project (rare diseases, medical devices, and nutrition) will serve as pilots for other biomedical research fields. By creating a single area for clinical research in Europe, this structure will contribute to the implementation of the Europe flagship initiative 2020 'Innovation Union', whose objectives include defragmentation of research and educational capacities, tackling the major societal challenges (starting with healthy aging), and removing barriers to bringing ideas to the market.

  2. Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries

    LENUS (Irish Health Repository)

    Whitfield, Kate

    2010-11-12

    Abstract Background \\'Compassionate use\\' programmes allow medicinal products that are not authorised, but are in the development process, to be made available to patients with a severe disease who have no other satisfactory treatment available to them. We sought to understand how such programmes are regulated in ten European Union countries. Methods The European Clinical Research Infrastructures Network (ECRIN) conducted a comprehensive survey on clinical research regulatory requirements, including questions on regulations of \\'compassionate use\\' programmes. Ten European countries, covering approximately 70% of the EU population, were included in the survey (Austria, Denmark, France, Germany, Hungary, Ireland, Italy, Spain, Sweden, and the UK). Results European Regulation 726\\/2004\\/EC is clear on the intentions of \\'compassionate use\\' programmes and aimed to harmonise them in the European Union. The survey reveals that different countries have adopted different requirements and that \\'compassionate use\\' is not interpreted in the same way across Europe. Four of the ten countries surveyed have no formal regulatory system for the programmes. We discuss the need for \\'compassionate use\\' programmes and their regulation where protection of patients is paramount. Conclusions \\'Compassionate use\\' is a misleading term and should be replaced with \\'expanded access\\'. There is a need for expanded access programmes in order to serve the interests of seriously ill patients who have no other treatment options. To protect these patients, European legislation needs to be more explicit and informative with regard to the regulatory requirements, restrictions, and responsibilities in expanded access programmes.

  3. A European multi-language initiative to make the general population aware of independent clinical research

    DEFF Research Database (Denmark)

    Mosconi, Paola; Antes, Gerd; Barbareschi, Giorgio

    2016-01-01

    BACKGROUND: The ECRAN (European Communication on Research Awareness Needs) project was initiated in 2012, with support from the European Commission, to improve public knowledge about the importance of independent, multinational, clinical trials in Europe. METHODS: Participants in the ECRAN...... consortium included clinicians and methodologists directly involved in clinical trials; researchers working in partnership with the public and patients; representatives of patients; and experts in science communication. We searched for, and evaluated, relevant existing materials and developed additional...... 2. An animated film about clinical trials, dubbed in the 23 official languages of the European Community, and an interactive tutorial 3. An inventory of resources, available in 23 languages, searchable by topic, author, and media type 4. Two educational games for young people, developed in six...

  4. The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC): experiences from a successful ERS Clinical Research Collaboration.

    Science.gov (United States)

    Chalmers, James D; Crichton, Megan; Goeminne, Pieter C; Loebinger, Michael R; Haworth, Charles; Almagro, Marta; Vendrell, Montse; De Soyza, Anthony; Dhar, Raja; Morgan, Lucy; Blasi, Francesco; Aliberti, Stefano; Boyd, Jeanette; Polverino, Eva

    2017-09-01

    In contrast to airway diseases like chronic obstructive pulmonary disease or asthma, and rare diseases such as cystic fibrosis, there has been little research and few clinical trials in bronchiectasis. Guidelines are primarily based on expert opinion and treatment is challenging because of the heterogeneous nature of the disease. In an effort to address decades of underinvestment in bronchiectasis research, education and clinical care, the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) was established in 2012 as a collaborative pan-European network to bring together bronchiectasis researchers. The European Respiratory Society officially funded EMBARC in 2013 as a Clinical Research Collaboration, providing support and infrastructure to allow the project to grow. EMBARC has now established an international bronchiectasis registry that is active in more than 30 countries both within and outside Europe. Beyond the registry, the network participates in designing and facilitating clinical trials, has set international research priorities, promotes education and has participated in producing the first international bronchiectasis guidelines. This manuscript article the development, structure and achievements of EMBARC from 2012 to 2017. To understand the role of Clinical Research Collaborations as the major way in which the European Respiratory Society can stimulate clinical research in different disease areasTo understand some of the key features of successful disease registriesTo review key epidemiological, clinical and translational studies of bronchiectasis contributed by the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) project in the past 5 yearsTo understand the key research priorities identified by EMBARC for the next 5 years.

  5. Clinical research with children: the European legal framework and its implementation in French and Italian law.

    Science.gov (United States)

    Altavilla, Annagrazia

    2008-07-01

    According to the International Convention of the Rights of the Child, an improvement of the protection of the rights of children in Europe should be accomplished by inserting the principle of best interests and evolving capacities in the legal framework related to paediatric clinical research. In this article, an overview is given of the European legal framework governing clinical research on minors in a comparative approach. The lack of coordination between different International and European ethical/ legal statements and its impact on national legislations is evaluated by analyzing provisions that have been foreseen in Italy and in France as a result of the ratification/implementation process. A presentation of the perspectives of paediatric research in Europe is provided.

  6. Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN)

    DEFF Research Database (Denmark)

    Kubiak, Christine; de Andres-Trelles, Fernando; Kuchinke, Wolfgang

    2009-01-01

    with cell therapy, etc.); diagnostic studies; clinical research on nutrition; other interventional clinical research (including trials in complementary and alternative medicine, trials with collection of blood or tissue samples, physiology studies, etc.); and epidemiology studies. Our classification......BACKGROUND: Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception across the EU member states. METHODS: In order to summarise the current situation...... in relation to the wide spectrum of clinical research, the European Clinical Research Infrastructures Network (ECRIN) developed a multinational survey in ten European countries. However a lack of common classification framework for major categories of clinical research was identified, and therefore reaching...

  7. Validation of the "United Registries for Clinical Assessment and Research" (UR-CARE), a European online registry for clinical care and research in Inflammatory Bowel Disease

    DEFF Research Database (Denmark)

    Burisch, Johan; Gisbert, Javier P; Siegmund, Britta

    2018-01-01

    Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the databas...

  8. Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN

    Directory of Open Access Journals (Sweden)

    Sanz Nuria

    2009-10-01

    Full Text Available Abstract Background Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception across the EU member states. Methods In order to summarise the current situation in relation to the wide spectrum of clinical research, the European Clinical Research Infrastructures Network (ECRIN developed a multinational survey in ten European countries. However a lack of common classification framework for major categories of clinical research was identified, and therefore reaching an agreement on a common classification was the initial step in the development of the survey. Results The ECRIN transnational working group on regulation, composed of experts in the field of clinical research from ten European countries, defined seven major categories of clinical research that seem relevant from both the regulatory and the scientific points of view, and correspond to congruent definitions in all countries: clinical trials on medicinal products; clinical trials on medical devices; other therapeutic trials (including surgery trials, transplantation trials, transfusion trials, trials with cell therapy, etc.; diagnostic studies; clinical research on nutrition; other interventional clinical research (including trials in complementary and alternative medicine, trials with collection of blood or tissue samples, physiology studies, etc.; and epidemiology studies. Our classification was essential to develop a survey focused on protocol submission to ethics committees and competent authorities, procedures for amendments, requirements for sponsor and insurance, and adverse event reporting following five main phases: drafting, consensus, data collection, validation, and finalising. Conclusion The list of clinical research categories as used for the survey could serve as a contribution to the, much needed, task of harmonisation and

  9. Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN).

    Science.gov (United States)

    Kubiak, Christine; de Andres-Trelles, Fernando; Kuchinke, Wolfgang; Huemer, Karl-Heinz; Thirstrup, Steffen; Whitfield, Kate; Libersa, Christian; Barraud, Béatrice; Grählert, Xina; Dreier, Gabriele; Grychtol, Ruth; Temesvari, Zsuzsa; Blasko, Gyorgy; Kardos, Gabriella; O'Brien, Timothy; Cooney, Margaret; Gaynor, Siobhan; Schieppati, Arrigo; Sanz, Nuria; Hernandez, Raquel; Asker-Hagelberg, Charlotte; Johansson, Hanna; Bourne, Sue; Byrne, Jane; Asghar, Adeeba; Husson, Jean-Marc; Gluud, Christian; Demotes-Mainard, Jacques

    2009-10-16

    Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception across the EU member states. In order to summarise the current situation in relation to the wide spectrum of clinical research, the European Clinical Research Infrastructures Network (ECRIN) developed a multinational survey in ten European countries. However a lack of common classification framework for major categories of clinical research was identified, and therefore reaching an agreement on a common classification was the initial step in the development of the survey. The ECRIN transnational working group on regulation, composed of experts in the field of clinical research from ten European countries, defined seven major categories of clinical research that seem relevant from both the regulatory and the scientific points of view, and correspond to congruent definitions in all countries: clinical trials on medicinal products; clinical trials on medical devices; other therapeutic trials (including surgery trials, transplantation trials, transfusion trials, trials with cell therapy, etc.); diagnostic studies; clinical research on nutrition; other interventional clinical research (including trials in complementary and alternative medicine, trials with collection of blood or tissue samples, physiology studies, etc.); and epidemiology studies. Our classification was essential to develop a survey focused on protocol submission to ethics committees and competent authorities, procedures for amendments, requirements for sponsor and insurance, and adverse event reporting following five main phases: drafting, consensus, data collection, validation, and finalising. The list of clinical research categories as used for the survey could serve as a contribution to the, much needed, task of harmonisation and simplification of the regulatory requirements for clinical research

  10. Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN)

    LENUS (Irish Health Repository)

    Kubiak, Christine

    2009-10-16

    Abstract Background Thorough knowledge of the regulatory requirements is a challenging prerequisite for conducting multinational clinical studies in Europe given their complexity and heterogeneity in regulation and perception across the EU member states. Methods In order to summarise the current situation in relation to the wide spectrum of clinical research, the European Clinical Research Infrastructures Network (ECRIN) developed a multinational survey in ten European countries. However a lack of common classification framework for major categories of clinical research was identified, and therefore reaching an agreement on a common classification was the initial step in the development of the survey. Results The ECRIN transnational working group on regulation, composed of experts in the field of clinical research from ten European countries, defined seven major categories of clinical research that seem relevant from both the regulatory and the scientific points of view, and correspond to congruent definitions in all countries: clinical trials on medicinal products; clinical trials on medical devices; other therapeutic trials (including surgery trials, transplantation trials, transfusion trials, trials with cell therapy, etc.); diagnostic studies; clinical research on nutrition; other interventional clinical research (including trials in complementary and alternative medicine, trials with collection of blood or tissue samples, physiology studies, etc.); and epidemiology studies. Our classification was essential to develop a survey focused on protocol submission to ethics committees and competent authorities, procedures for amendments, requirements for sponsor and insurance, and adverse event reporting following five main phases: drafting, consensus, data collection, validation, and finalising. Conclusion The list of clinical research categories as used for the survey could serve as a contribution to the, much needed, task of harmonisation and simplification of the

  11. European DHC Research Issues

    Energy Technology Data Exchange (ETDEWEB)

    Wiltshire, Robin; Williams, Jonathan (Building Research Establishment, BRE, Bucknalls Lane, Watford (United Kingdom)); Werner, Sven (Halmstad University, School of Business and Engineering, Halmstad (Sweden))

    2008-09-15

    Euroheat and Power is now working towards a European Technology Platform for District Heating and Cooling. In response to this important European DHC research initiative, a preliminary detailed list of research issues within 18 dimensions was elaborated and communicated to more than 100 people in February 2008. After additions and comments received, an updated list of research issues was again distributed in July 2008. This paper contains the current list of suggested research issues

  12. [Regulations of the ethical evaluation system of scientific and clinical research in connection with Poland joining the European Union].

    Science.gov (United States)

    Raszeja, Stefan

    2004-01-01

    The author has discussed the procedures of the Bioethical Commission of a biomedical research assessment and clinical trials based on analysis of the directives of the European Commission. Particularly criticized was the omission of the role of local committees in the case of the multi-center studies. Also underlined was a necessity to inform the examined persons, in a wider and more understandable fashion, about an essence of the examination and the expected level of risk.

  13. Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN countries

    Directory of Open Access Journals (Sweden)

    Gluud Christian

    2012-03-01

    Full Text Available Abstract Background In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe. Methods We conducted a survey in order to identify the national regulatory requirements for major categories of clinical research in ten European Clinical Research Infrastructures Network (ECRIN countries-Austria, Denmark, France, Germany, Hungary, Ireland, Italy, Spain, Sweden, and United Kingdom-covering approximately 70% of the EU population. Here we describe the results for regulatory requirements for typical investigational medicinal products, in the ten countries. Results Our results show that the ten countries have fairly harmonised definitions of typical investigational medicinal products. Clinical trials assessing typical investigational medicinal products require authorisation from a national competent authority in each of the countries surveyed. The opinion of the competent authorities is communicated to the trial sponsor within the same timelines, i.e., no more than 60 days, in all ten countries. The authority to which the application has to be sent to in the different countries is not fully harmonised. Conclusion The Directive 2001/20/EC defined the term 'investigational medicinal product' and all regulatory requirements described therein are applicable to investigational medicinal products. Our survey showed, however, that those requirements had been adopted in ten European countries, not for investigational medicinal products overall, but rather a narrower category which we term 'typical' investigational medicinal products. The result is partial EU harmonisation of requirements and a relatively navigable landscape for the sponsor regarding typical investigational medicinal products.

  14. The European Hematology Association Roadmap for European Hematology Research : A consensus document

    NARCIS (Netherlands)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology

  15. The European Hematology Association Roadmap for European Hematology Research : a consensus document

    NARCIS (Netherlands)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology

  16. Consensus document on European brain research

    DEFF Research Database (Denmark)

    Di Luca, Monica; Baker, Mary; Corradetti, Renato

    2011-01-01

    will increase exponentially in the years to come due to ageing of the European population, it is necessary to act now in order to curb this increase and possibly reverse the trend. Thus, establishing a strong European platform supporting basic and clinical research in neuroscience is needed to confront...... the economic and social challenge posed by management of brain diseases in European countries. To setup a platform for discussion, EBC published in 2006 a Consensus Document on European Brain Research, describing needs and achievements of research in Europe and presenting proposals for future research programs....... Since 2006, European research in neuroscience has advanced tremendously. The present document represents an update elaborated to reflect changes in research priorities and advances in brain research that have taken place since 2006. The same approach and format have been used here as in the previous...

  17. Clinical Research

    DEFF Research Database (Denmark)

    Christensen, Irene

    2016-01-01

    This paper is about the logic of problem solving and the production of scientific knowledge through the utilisation of clinical research perspective. Ramp-up effectiveness, productivity, efficiency and organizational excellence are topics that continue to engage research and will continue doing so...... for years to come. This paper seeks to provide insights into ramp-up management studies through providing an agenda for conducting collaborative clinical research and extend this area by proposing how clinical research could be designed and executed in the Ramp- up management setting....

  18. Action Research in European perspective

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2004-01-01

    The article gives an overview of how different Italian and Danish contributions to action research can be viewed in an European perspective.......The article gives an overview of how different Italian and Danish contributions to action research can be viewed in an European perspective....

  19. Gender perspectives in European research.

    Science.gov (United States)

    Klinge, Ineke

    2008-01-01

    Attention to sex and gender aspects in biomedical and health-related research has been a major initiative of the EU gender equality policy for research. The EU funded GenderBasic project (2005-2008), conceived to stimulate this attention to sex and gender and to provide practical tools to researchers, resulted in the publication of 10 reviews by high-level scientists in a Supplement to Gender Medicine in December 2007: "Bringing Gender Expertise to Biomedical and Health-Related Research". Four commissioned reviews covered methodological aspects of addressing sex and gender in biomedical research--ranging from basic, molecular to public health research--next to six reviews that addressed sex and gender aspects relevant to selected health areas: anxiety disorders, asthma, metabolic syndrome, nutrigenomics, osteoporosis and work-related health. The review articles, that were discussed at an expert meeting, attended - upon invitation - by a mixed audience of basic and clinical researchers, epidemiologists, social scientists and gender researchers, came up with excellent state of the art data, solutions to methodological and conceptual problems, practical tools and interesting questions for further research. The expert meeting created great enthusiasm among the participants and a real exchange took place among researchers from various backgrounds. Most life sciences researchers were familiar with the concept of sex differences but confessed that the effects of socially constructed gender until now, had received too little attention. The GenderBasic project yielded three major achievements for European research: (1) it stimulated and promoted research into sex differences; (2) it stimulated research into the workings of gender, illustrated by useful examples in particular in understanding masculinity and its effects on the health of individual men; (3) it highlighted sex-gender interaction and granted gender a prominent place on the research agenda that resulted from

  20. Causality in Europeanization Research

    DEFF Research Database (Denmark)

    Lynggaard, Kennet

    2012-01-01

    to develop discursive institutional analytical frameworks and something that comes close to the formulation of hypothesis on the effects of European Union (EU) policies and institutions on domestic change. Even if these efforts so far do not necessarily amount to substantive theories or claims of causality...

  1. 'Mind the gap' between the development of therapeutic innovations and the clinical practice in oncology: A proposal of the European Organisation for Research and Treatment of Cancer (EORTC) to optimise cancer clinical research.

    Science.gov (United States)

    Kempf, Emmanuelle; Bogaerts, Jan; Lacombe, Denis; Liu, Lifang

    2017-11-01

    In Europe, most of the cancer clinical research dedicated to therapeutic innovations aims primarily at regulatory approval. Once an anticancer drug enters the common market, each member state determines its real-world use based on its own criteria: pricing, reimbursement and clinical indications. Such an innovation-centred clinical research landscape might neglect patient-relevant issues in real-world setting, such as comparative effectiveness of distinct treatment options or long-term safety monitoring. The European Organisation for Research and Treatment of Cancer (EORTC) advocates reforming the current 'innovation-centred' system to a truly 'patient-centred' paradigm with systematically coordinated applied clinical research in conjunction with drug development, featuring the following strategy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Ethical principles and legal requirements for pediatric research in the EU: an analysis of the European normative and legal framework surrounding pediatric clinical trials.

    Science.gov (United States)

    Pinxten, Wim; Dierickx, Kris; Nys, Herman

    2009-10-01

    The involvement of minors in clinical research is inevitable to catch up with the lack of drugs labeled for pediatric use. To encourage the responsible conduct of pediatric clinical trials in the EU, an extensive legal framework has been developed over the past decade in which the practical, ethical, legal, social, and commercial issues in pediatric research are addressed. In this article, the European legal framework surrounding pediatric clinical trials is analyzed from the perspective of the major ethical concerns in pediatric research. The four principles of biomedical ethics will be used as a conceptual framework (1) to map the ethical issues addressed in the European legal framework, (2) to study how these issues are commonly handled in competent adults, (3) to detect workability problems of these paradigmatic approaches in the specific setting of pediatric research, and (4) to illustrate the strong urge to differentiate, specify, or adjust these paradigmatic approaches to guarantee their successful operation in pediatric research. In addition, a concise comparative analysis of the European regulation will be made. To conclude our analysis, we integrate our findings in the existing ethical discussions on issues specific to pediatric clinical research.

  3. European research priorities for intracerebral haemorrhage

    DEFF Research Database (Denmark)

    Steiner, Thorsten; Petersson, Jesper; Al-Shahi Salman, Rustam

    2011-01-01

    . No standardised diagnostic workup for the detection of the various underlying causes of ICH currently exists, and the evidence for medical or surgical therapeutic interventions remains limited. A dedicated European research programme for ICH is needed to identify ways to reduce the burden of ICH-related death...... and disability. The European Research Network on Intracerebral Haemorrhage EURONICH is a multidisciplinary academic research collaboration that has been established to define current research priorities and to conduct large clinical studies on all aspects of ICH....

  4. A European Approach to Clinical Investigator Training

    Directory of Open Access Journals (Sweden)

    Jean-Marie eBoeynaems

    2013-09-01

    Full Text Available A better education and training of clinical investigators and their teams is one of the factors that could foster the development of clinical research in Europe, a key objective of the Innovative Medicines Initiative (IMI. PharmaTrain (an IMI programme on training in medicines development and ECRIN (European Clinical Research Infrastructures Network have joined forces to address this issue. An advisory group composed of representatives of universities, pharmaceutical companies and other organisations met four times between June 2011 and July 2012. This resulted in a position paper proposing a strategy to improve and harmonize clinical investigator training in Europe, and including a detailed syllabus and list of learning outcomes. Major recommendations are the establishment of minimal and mutually recognized certification requirement for investigators throughout the EU and the creation of a European platform to provide a suitable course and examination infrastructure.

  5. Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN) countries

    DEFF Research Database (Denmark)

    Gluud, Christian; Kubiak, Christine; Whitfield, Kate

    2012-01-01

    In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe.......In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe....

  6. EERA and Its European Conferences on Educational Research: A Patchwork of Research on European Educational Research

    Science.gov (United States)

    Keiner, Edwin; Hofbauer, Susann

    2014-01-01

    The process of Europeanisation is closely linked to the process of an emerging European Educational Research Area and an education research identity. The European Conferences on Educational Research (ECER), European Educational Research Association (EERA) and its networks are involved in new directions and strands of educational research in…

  7. Cost-benefit assessment of using electronic health records data for clinical research versus current practices: Contribution of the Electronic Health Records for Clinical Research (EHR4CR) European Project.

    Science.gov (United States)

    Beresniak, Ariel; Schmidt, Andreas; Proeve, Johann; Bolanos, Elena; Patel, Neelam; Ammour, Nadir; Sundgren, Mats; Ericson, Mats; Karakoyun, Töresin; Coorevits, Pascal; Kalra, Dipak; De Moor, Georges; Dupont, Danielle

    2016-01-01

    The widespread adoption of electronic health records (EHR) provides a new opportunity to improve the efficiency of clinical research. The European EHR4CR (Electronic Health Records for Clinical Research) 4-year project has developed an innovative technological platform to enable the re-use of EHR data for clinical research. The objective of this cost-benefit assessment (CBA) is to assess the value of EHR4CR solutions compared to current practices, from the perspective of sponsors of clinical trials. A CBA model was developed using an advanced modeling approach. The costs of performing three clinical research scenarios (S) applied to a hypothetical Phase II or III oncology clinical trial workflow (reference case) were estimated under current and EHR4CR conditions, namely protocol feasibility assessment (S1), patient identification for recruitment (S2), and clinical study execution (S3). The potential benefits were calculated considering that the estimated reduction in actual person-time and costs for performing EHR4CR S1, S2, and S3 would accelerate time to market (TTM). Probabilistic sensitivity analyses using Monte Carlo simulations were conducted to manage uncertainty. Should the estimated efficiency gains achieved with the EHR4CR platform translate into faster TTM, the expected benefits for the global pharmaceutical oncology sector were estimated at €161.5m (S1), €45.7m (S2), €204.5m (S1+S2), €1906m (S3), and up to €2121.8m (S1+S2+S3) when the scenarios were used sequentially. The results suggest that optimizing clinical trial design and execution with the EHR4CR platform would generate substantial added value for pharmaceutical industry, as main sponsors of clinical trials in Europe, and beyond. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. The european hematology association roadmap for european hematology research : A consensus document

    NARCIS (Netherlands)

    A. Engert (Andreas); C.L. Balduini (Carlo); A. Brand (Anneke); B. Coiffier (Bertrand); C. Cordonnier (Charlotte); H. Döhner (Hartmut); De Wit, T.D. (Thom Duyvené); Eichinger, S. (Sabine); W.E. Fibbe (Willem); Green, T. (Tony); De Haas, F. (Fleur); A. Iolascon (Achille); T. Jaffredo (Thierry); F. Rodeghiero (Francesco); G. Salles (Gilles); J.J. Schuringa (Jan Jacob)

    2016-01-01

    textabstractThe European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European

  9. European Research in Marine Structures

    DEFF Research Database (Denmark)

    Soares, C.Guedes; Jensen, Jørgen Juncher; Incecik, A.

    2012-01-01

    An overview is presented of the results obtained in Europe by a network with a large number of research groups in the field of Marine Structures during a period of 6 years. The European Union has funded a project aimed at improving the collaboration among European research groups specialized...... in marine structures, which has led, among other results to a number of benchmark studies organized in 6 main topical areas, namely, Methods and Tools for Loads and Load Effects, Methods and Tools for Strength Assessment, Experimental Analysis of Structures, Materials and Fabrication of Structures, Methods...... and Tools for Structural Design and Optimization and Structural Reliability, Safety and Environmental Protection. This paper presents an overview of various studies performed, which helps identifying the level of consistency and robustness of different numeric tools used in this field....

  10. popscience - European Researchers Night 2014

    CERN Multimedia

    Jeanneret, Guillaume

    2014-01-01

    Vendredi 26 septembre 2014, le CERN célèbrera la Nuit européenne des chercheurs à Genève et à St-Genis-Pouilly. Le thème de l’édition 2014 est inspiré d’Andy Warhol : « Pop science is for everyone ». On Friday 26 September 2014, CERN will be celebrating European Researchers' Night at three venues in Geneva and St. Genis-Pouilly. Inspired by Andy Warhol, this year's theme is “Pop science is for everyone”.

  11. The European Hematology Association Roadmap for European Hematology Research

    DEFF Research Database (Denmark)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke

    2016-01-01

    research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness...

  12. European perspectives on security research

    CERN Document Server

    2011-01-01

    Europe’s networked societies of today are shaped by a growing interconnection in almost all areas of life. The complexity of our infrastructures and the concurrent accessibility to means of destruction by terrorist groups and individual perpetrators call for innovative security solutions. However, such evolving innovations inevitably raise fundamental questions of concern in our societies. How do we balance the imperatives of securing our citizens and infrastructures on the one hand, and of protecting of our sacredly held civil liberties on the other? The topical network ‘Safety and Security’ of acatech – the German Academy of Science and Engineering – invited experts from the science academies of various European countries to share their perspectives on security research and the aspect of safety during a two-day workshop hosted by the Fraunhofer Institute for High-Speed Dynamics, Ernst-Mach-Institut in March 2010. This publication is a compilation of contributions made during the workshop.

  13. The European Social Survey and European research policy

    DEFF Research Database (Denmark)

    Kropp, Kristoffer

    2017-01-01

    This article analyses the history of the European Social Survey (ESS) and its relationship to changes in European research policy, using Bourdieu’s field-analytical approach. It argues that the success of the ESS relied on three interwoven processes that we can understand theoretically in terms o...

  14. Clinical Research and Clinical Trials

    Science.gov (United States)

    ... Contracts section of the NIH website. Find NICHD Clinical Trials NIH maintains the ClinicalTrials.gov website as the main database of publicly and privately funded clinical trials. Each trial has its own pre-defined research ...

  15. Transnational Lives in European Educational Research

    Science.gov (United States)

    Lawn, Martin

    2014-01-01

    Transnational collaboration by educational researchers in Europe has grown fast since the mid-1990s and the means to support it have become more easily accessible. A study of the growth of the European Educational Research Association (EERA) since its foundation in the mid-1990s shows how transnational research in European education began, and how…

  16. Reproducible diagnosis of Chronic Lymphocytic Leukemia by flow cytometry: an European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) harmonisation project.

    Science.gov (United States)

    Rawstron, Andy C; Kreuzer, Karl-Anton; Soosapilla, Asha; Spacek, Martin; Stehlikova, Olga; Gambell, Peter; McIver-Brown, Neil; Villamor, Neus; Psarra, Katherina; Arroz, Maria; Milani, Raffaella; de la Serna, Javier; Cedena, M Teresa; Jaksic, Ozren; Nomdedeu, Josep; Moreno, Carol; Rigolin, Gian Matteo; Cuneo, Antonio; Johansen, Preben; Johnsen, Hans E; Rosenquist, Richard; Niemann, Carsten Utoft; Kern, Wolfgang; Westerman, David; Trneny, Marek; Mulligan, Stephen; Doubek, Michael; Pospisilova, Sarka; Hillmen, Peter; Oscier, David; Hallek, Michael; Ghia, Paolo; Montserrat, Emili

    2017-10-10

    The diagnostic criteria for CLL rely on morphology and immunophenotype. Current approaches have limitations affecting reproducibility and there is no consensus on the role of new markers. The aim of this project was to identify reproducible criteria and consensus on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of 35 potential markers as "required" or "recommended" for CLL diagnosis, consensus being defined as >75% and >50% agreement, respectively. An approach to validate "required" markers using normal peripheral blood was developed. Responses were received from 150 participants with a diagnostic workload >20 CLL cases per week in 23/150 (15%), 5-20 in 82/150 (55%) and 97% concordance with current approaches. A pilot study to validate staining quality was completed in eleven centres. Markers considered as "required" for the diagnosis of CLL by the participants in this study (CD19, CD5, CD20, CD23, Kappa and Lambda) are consistent with current diagnostic criteria and practice. Importantly, a reproducible approach to validate and apply these markers in individual laboratories has been identified. Finally, a consensus "recommended" panel of markers to refine diagnosis in borderline cases (CD43, CD79b, CD81, CD200, CD10, ROR1) has been defined and will be prospectively evaluated. This article is protected by copyright. All rights reserved. © 2017 International Clinical Cytometry Society.

  17. Consensus document on European brain research

    DEFF Research Database (Denmark)

    Di Luca, Monica; Baker, Mary; Corradetti, Renato

    2011-01-01

    the economic and social challenge posed by management of brain diseases in European countries. To setup a platform for discussion, EBC published in 2006 a Consensus Document on European Brain Research, describing needs and achievements of research in Europe and presenting proposals for future research programs....... Since 2006, European research in neuroscience has advanced tremendously. The present document represents an update elaborated to reflect changes in research priorities and advances in brain research that have taken place since 2006. The same approach and format have been used here as in the previous......Psychiatric and neurological diseases combined represent a considerable social and economic burden in Europe. A recent study conducted by the European Brain Council (EBC) quantified the 'cost and burden' of major brain diseases in Europe, amounting to €386bn per year. Considering that these costs...

  18. Consensus document on European brain research.

    Science.gov (United States)

    Olesen, Jes; Baker, Mary G; Freund, Tamas; di Luca, Monica; Mendlewicz, Julien; Ragan, Ian; Westphal, Manfred

    2006-08-01

    Brain disease psychiatric and neurologic disease combined represents a considerable social and economic burden in Europe. Data collected by the World Health Organization (WHO) suggest that brain diseases are responsible for 35% of Europe's total disease burden. An analysis of all health economic studies of brain diseases in Europe, published by the European Brain Council (EBC) in June 2005, estimated the total cost of brain disease in Europe in 2004 to be Euro 386 billion. That burden is set to grow, mainly due to the fact that the European population is ageing. Investment in brain sciences does not match that burden now, let alone in the future. Brain research received only 8% of the life science budget in the European Commission's Fifth Framework Programme, which represents less than 0.01% of the annual cost of brain disorders for that period. Over the last decade, Europe has been losing ground to the USA and Japan in terms of both basic and clinical research. Many of Europe's young researchers are taking up posts in the USA and staying there. Big pharmaceutical companies are fleeing Europe for the USA, taking their drug development programmes with them. Research in the brain sciences now holds the promise of therapies that halt and even reverse neurodegeneration, of better diagnostic tools, neural prostheses for the paralysed and drugs for depression and anxiety that are tailored to the individual, thereby eliminating or reducing side effects. Our growing understanding of the normal brain could lead to better prevention of brain disease and to more effective teaching methods. The need for innovative treatments has never been greater, and Europe boasts clusters of excellent researchers in biotechnology who could collaborate with brain scientists and the pharmaceutical industry to realise this promise. But if Europe is to seize these opportunities and meet the challenge of brain disease, it needs to go forward on the basis of greater collaboration between

  19. A European Research Agenda for Lifelong Learning

    NARCIS (Netherlands)

    Sloep, Peter

    2008-01-01

    Sloep, P. (2008). A European Research Agenda for Lifelong Learning. Paper read at EADTU Annual Conference 2008, Lifelong learning in higher education: networked teaching and learning in a knowledge society. September, 18-19, 2008, Poitiers, France.

  20. European Network of Bipolar Research Expert Centre (ENBREC)

    DEFF Research Database (Denmark)

    Henry, Chantal; Andreassen, Ole A; Barbato, Angelo

    2013-01-01

    clinical decision-making as well as being applicable to research. Reliable, established measures have been prioritised, and instruments have been translated and validated when necessary. An electronic healthcare record and monitoring system (e-ENBREC©) has been developed to collate the data. Protocols...... of a critical mass of expertise and multicentre collaborative projects. Within the framework of the European FP7 programme, we developed a European Network of Bipolar Research Expert Centres (ENBREC) designed specifically to facilitate EU-wide studies. ENBREC provides an integrated support structure...... facilitating research on disease mechanisms and clinical outcomes across six European countries (France, Germany, Italy, Norway, Spain and the UK). The centres are adopting a standardised clinical assessment that explores multiple aspects of bipolar disorder through a structured evaluation designed to inform...

  1. The European research council takes flight.

    Science.gov (United States)

    Antonoyiannakis, Manolis; Hemmelskamp, Jens; Kafatos, Fotis C

    2009-03-06

    In 2007, the European Research Council (ERC) was launched amid much fanfare with the goal of spearheading Europe's aspirations to become the most dynamic and competitive knowledge-based society in the world. Here, we examine the results of the first two ERC calls for research grants and discuss the latest developments and the challenges that face this unique research council.

  2. Does the European Clinical Trials Directive really improve clinical trial approval time?

    NARCIS (Netherlands)

    Lambers Heerspink, Hiddo J.; Dobre, Daniela; Hillege, Hans L.; Grobbee, Diederick E.; de Zeeuw, Dick

    2008-01-01

    AIMS To facilitate and improve clinical research within Europe, the European Union (EU) adopted in 2001 the Clinical Trials Directive (EUCTD). The aim of this study was to compare duration between submission of a clinical drug trial application and approval by regulatory authorities in EU countries

  3. Understanding the infrastructure of European Research Infrastructures

    DEFF Research Database (Denmark)

    Lindstrøm, Maria Duclos; Kropp, Kristoffer

    2017-01-01

    European Research Infrastructure Consortia (ERIC) are a new form of legal and financial framework for the establishment and operation of research infrastructures in Europe. Despite their scope, ambition, and novelty, the topic has received limited scholarly attention. This article analyses one ERIC...... within the social sciences—the European Social Survey (ESS). We observe that the ESS experienced a decline in the number of participating countries upon its acquisition of ERIC status. We explore the links between methodological, organizational, and financial elements in the process through which the ESS...... became an ERIC using the Bowker and Star’s sociology of infrastructures. We conclude that focusing on ERICs as a European standard for organising and funding research collaboration gives new insights into the problems of membership, durability, and standardisation faced by research infrastructures...

  4. Understanding the infrastructure of European Research Infrastructures

    DEFF Research Database (Denmark)

    Lindstrøm, Maria Duclos; Kropp, Kristoffer

    2017-01-01

    European Research Infrastructure Consortia (ERICs) are a new form of legal and financial framework for the establishment and operation of research infrastructures in Europe. Despite their scope, ambition and novelty, the topic has received limited scholarly attention. This paper analyses one ERIC...... within the social sciences – the European Social Survey (ESS). We observe that the ESS experienced a decline in the number of participating countries upon its acquisition of ERIC status. We explore the links between methodological, organisational and financial elements in the process through which...... the ESS became an ERIC using the Bowker and Star’s sociology of infrastructures. We conclude that focusing on ERICs as a European standard for organising and funding research collaboration gives new insights into the problems of membership, durability and standardisation faced by research infrastructures...

  5. [European Union funds and clinical toxicology].

    Science.gov (United States)

    Wiszniewiecka, Monika; Cejrowski, Daniel; Sein Anand, Jacek

    2015-01-01

    Since 2014 we are heading the third programming period of help from European Union (EU). The new budget will run until 2020. From common resources of EU, 106 billion euro will reach Poland, of which about 82.3 billion to cohesion policy, levelling differences of regional development. Clinical toxicology centres will be able to apply for funding under the allocation for the health service. Polish health service very actively benefited from EU funds in previous programming periods, between 2004-2006, and 2007-2013. Thanks to grants from the EU, a large number of health centres were built or renovated. Unfortunately the needs of hospitals, which were underinvested for many years, exceeded available funds according to UE programmes. Except investment projects, also projects training of health professionals were executed. In the current programming period European Union will still support projects aimed at health service. Clinical toxicology centres should have a try of using this period to fulfil their plans.

  6. European commission research activities on iodine

    Energy Technology Data Exchange (ETDEWEB)

    Loggia, E. della [European Commission, Brussels (Belgium)

    1996-12-01

    The research on iodine, as on other important fission products which would be released during a severe accident, carried out directly or organized by the European Commission stems from the Euratom Treaty, namely from Chapter III of the treaty which deals with the protection of the health of the population against radiations and from Chapter I which deals with research. In this paper we do not consider the Commission radiological protection programme: we limit ourselves to the presentation of the research carried out on Iodine as part of the most recent source term studies within the framework Programmes as are called the research programme of the European Commission, usually valid for a 4 year periods. The research activities are carried out by the European Commission either directly through the Joint Research Centres (JRC) or indirectly through collaboration with research organizations of Member States. Concerning the iodine research carried out as Direct Action in the Joint Research Centres, are mentioned here the most relevant activities carried out in this field at the JRC of Ispra and Karlsruhe (TUI). As Indirect Action, we present here the results of some studies allocated by the European Commission to experts of research organizations of Member Countries, followed by a short description of the main results achieved by the Reinforced Concerted Action, within the III Framework Programme (1992-1995). At the end of the paper are described the research on iodine being carried out or proposed within the IV Framework Programme (1995-1998). Mention is also done of the Commission participation, relevant in terms of financial and human efforts, to the PHEBUS FP Project. (author) refs.

  7. Research Areas - Clinical Trials

    Science.gov (United States)

    Information about NCI programs and initiatives that sponsor, conduct, develop, or support clinical trials, including NCI’s Clinical Trial Network (NCTN) and NCI Community Oncology Research Program (NCORP) initiatives.

  8. European Research towards Future Wireless Communications

    DEFF Research Database (Denmark)

    Frederiksen, Flemming Bjerge; Prasad, Ramjee; Pedersen, Gert Frølund

    2005-01-01

    This paper presents an overview of four on-going European research projects in the field of mobile and wireless communications leading to the next generations of wireless communications. The projects started in 2004. They investigate requirements and definition of access technology, network...... architecture, antennas and propagation, security, services, applications and socio-economic impact....

  9. Clinical research informatics

    CERN Document Server

    Richesson, Rachel L

    2012-01-01

    This book provides foundational coverage of key areas, concepts, constructs, and approaches of medical informatics as it applies to clinical research activities, in both current settings and in light of emerging policies. The field of clinical research is fully characterized (in terms of study design and overarching business processes), and there is emphasis on information management aspects and informatics implications (including needed activities) within various clinical research environments. The purpose of the book is to provide an overview of clinical research (types), activities, and are

  10. The European Hematology Association Roadmap for European Hematology Research: a consensus document.

    Science.gov (United States)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-02-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Copyright© Ferrata Storti Foundation.

  11. Clinical Research Methodology 2: Observational Clinical Research.

    Science.gov (United States)

    Sessler, Daniel I; Imrey, Peter B

    2015-10-01

    Case-control and cohort studies are invaluable research tools and provide the strongest feasible research designs for addressing some questions. Case-control studies usually involve retrospective data collection. Cohort studies can involve retrospective, ambidirectional, or prospective data collection. Observational studies are subject to errors attributable to selection bias, confounding, measurement bias, and reverse causation-in addition to errors of chance. Confounding can be statistically controlled to the extent that potential factors are known and accurately measured, but, in practice, bias and unknown confounders usually remain additional potential sources of error, often of unknown magnitude and clinical impact. Causality-the most clinically useful relation between exposure and outcome-can rarely be definitively determined from observational studies because intentional, controlled manipulations of exposures are not involved. In this article, we review several types of observational clinical research: case series, comparative case-control and cohort studies, and hybrid designs in which case-control analyses are performed on selected members of cohorts. We also discuss the analytic issues that arise when groups to be compared in an observational study, such as patients receiving different therapies, are not comparable in other respects.

  12. Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policy. European Society of Human Genetics and European Society of Human Reproduction and Embryology.

    Science.gov (United States)

    Harper, Joyce C; Geraedts, Joep; Borry, Pascal; Cornel, Martina C; Dondorp, Wybo; Gianaroli, Luca; Harton, Gary; Milachich, Tanya; Kääriäinen, Helena; Liebaers, Inge; Morris, Michael; Sequeiros, Jorge; Sermon, Karen; Shenfield, Françoise; Skirton, Heather; Soini, Sirpa; Spits, Claudia; Veiga, Anna; Vermeesch, Joris Robert; Viville, Stéphane; de Wert, Guido; Macek, Milan

    2013-11-01

    In March 2005, a group of experts from the European Society of Human Genetics and European Society of Human Reproduction and Embryology met to discuss the interface between genetics and assisted reproductive technology (ART), and published an extended background paper, recommendations and two Editorials. Seven years later, in March 2012, a follow-up interdisciplinary workshop was held, involving representatives of both professional societies, including experts from the European Union Eurogentest2 Coordination Action Project. The main goal of this meeting was to discuss developments at the interface between clinical genetics and ARTs. As more genetic causes of reproductive failure are now recognised and an increasing number of patients undergo testing of their genome before conception, either in regular health care or in the context of direct-to-consumer testing, the need for genetic counselling and preimplantation genetic diagnosis (PGD) may increase. Preimplantation genetic screening (PGS) thus far does not have evidence from randomised clinical trials to substantiate that the technique is both effective and efficient. Whole-genome sequencing may create greater challenges both in the technological and interpretational domains, and requires further reflection about the ethics of genetic testing in ART and PGD/PGS. Diagnostic laboratories should be reporting their results according to internationally accepted accreditation standards (International Standards Organisation - ISO 15189). Further studies are needed in order to address issues related to the impact of ART on epigenetic reprogramming of the early embryo. The legal landscape regarding assisted reproduction is evolving but still remains very heterogeneous and often contradictory. The lack of legal harmonisation and uneven access to infertility treatment and PGD/PGS fosters considerable cross-border reproductive care in Europe and beyond. The aim of this paper is to complement previous publications and provide

  13. ENSAR, a Nuclear Science Project for European Research Area

    NARCIS (Netherlands)

    Turzó, Ketel; Lewitowicz, Marek; Harakeh, Muhsin N.

    2015-01-01

    During the period from September 2010 to December 2014, the European project European Nuclear Science and Applications Research (ENSAR) coordinated research activities of the Nuclear Physics community performing research in three major subfields: Nuclear Structure, Nuclear Astrophysics, and Nuclear

  14. Inside CERN European Organization for Nuclear Research

    CERN Document Server

    Pol, Andri; Heuer, Rolf

    2013-01-01

    For most people locations that hold a particular importance for the development of our society and for the advancement of science and technology remain hidden from view. CERN, the European Organization for Nuclear Research, is best known for its giant particle accelerator. Here researchers take part in a diverse array of fundamental physical research, in the pursuit of knowledge that will perhaps one dayrevolutionize our understanding of the universe and life on our planet. The Swiss photographer Andri Pol mixed with this multicultural community of researchers and followed their work over an extended period of time. In doing so he created a unique portrait of this fascinating “underworld.” The cutting-edge research is given a human face and the pictures allow us to perceive how in this world of the tiniest particles the biggest connections are searched for. With an essay by Peter Stamm.

  15. The First European Interdisciplinary Ewing Sarcoma Research Summit

    Directory of Open Access Journals (Sweden)

    Heinrich eKovar

    2012-05-01

    Full Text Available The European Network for Cancer Research in Children and Adolescents (ENCCA provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA aims is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma, where long term survival rates are still below 20%. Despite significant progress in our understanding of Ewing sarcoma biology, clinical translation of promising laboratory results has not taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and 5 North American opinion leaders in December 2011 to exchange and critically discuss the state of the art in Ewing sarcoma research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.

  16. Clinical highlights from the 2016 European Respiratory Society International Congress

    Directory of Open Access Journals (Sweden)

    Nicolas Kahn

    2017-04-01

    Full Text Available This article contains highlights and a selection of the scientific advances from the European Respiratory Society (ERS Clinical Assembly (Assembly 1 and its six respective groups (Groups 1.1–1.6 that were presented at the 2016 ERS International Congress in London, UK. The most relevant topics for clinicians will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, diffuse and parenchymal lung diseases, and general practice and primary care. In this comprehensive review, the newest research and actual data will be discussed and put into perspective.

  17. Framework conditions facilitating paediatric clinical research

    Directory of Open Access Journals (Sweden)

    Alfarez Deborah

    2011-02-01

    Full Text Available Abstract The use of unlicensed and "off-label" medicines in children is widespread. Between 50-80% of the medicines currently administered to children have neither been tested nor authorized for their use in the paediatric population which represents approximately 25% of the whole European population. On 26 January 2007, entered into force the European Regulation of Paediatric Medicines. It aims at the quality of research into medicines for children but without subjecting the paediatric population to unnecessary clinical trial. This article addresses ethical and legal issues arising from the regulation and makes recommendations for the framework conditions facilitating the development of clinical research with children.

  18. European Science Research Organisations forge closer ties

    CERN Multimedia

    2001-01-01

    Effective collaboration has always been one of the foundations of CERN's success. An essential ingredient for collaboration is communication and a new body EIROFORUM has just held its first meeting in Brussels with the aim of developing greater cross fertilization of ideas and projects. Seven organisations, CERN, EMBL (molecular biology), ESA (space activities), ESO (astronomy and astrophysics), ESRF (synchrotron radiation), ILL (neutron source) and EFDA (fusion) are currently members of EIROFORUM. Common interest between the organisations in computational grid development, materials science, instrumentation, public outreach and technology transfer has made EIROFRUM an essential group for maximising these European research organisations' resources. Increasing involvement in the Sixth Framework Programme, Europe's research guidelines for the next four years, is also one of the goals of the group. CERN takes over the chair of EIROFORUM in July 2001 and the next meeting will be held on site on 24 October .

  19. EUDOR-A multi-centre research program: A naturalistic, European Multi-centre Clinical study of EDOR Test in adult patients with primary depression.

    Science.gov (United States)

    Sarchiapone, Marco; Iosue, Miriam; Carli, Vladimir; Amore, Mario; Baca-Garcia, Enrique; Batra, Anil; Cosman, Doina; Courtet, Philippe; Di Sciascio, Guido; Gusmao, Ricardo; Parnowski, Tadeusz; Pestality, Peter; Saiz, Pilar; Thome, Johannes; Tingström, Anders; Wojnar, Marcin; Zeppegno, Patrizia; Thorell, Lars-Håkan

    2017-03-23

    Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide. The aims of the present study are to test the effectiveness and the usefulness of the EDOR (ElectroDermal Orienting Reactivity) Test as a support in the suicide risk assessment of depressed patients and to assess the predictive value of electrodermal hyporeactivity, measured through the EDOR Test, for suicide and suicide attempt in adult patients with a primary diagnosis of depression. 1573 patients with a primary diagnosis of depression, whether currently depressed or in remission, have been recruited at 15 centres in 9 different European countries. Depressive symptomatology was evaluated through the Montgomery-Asberg Depression Scale. Previous suicide attempts were registered and the suicide intent of the worst attempt was rated according to the first eight items of the Beck Suicide Intent Scale. The suicide risk was also assessed according to rules and traditions at the centre. The EDOR Test was finally performed. During the EDOR Test, two fingers are put on gold electrodes and direct current of 0.5 V is passed through the epidermis of the fingers according to standards. A moderately strong tone is presented through headphones now and then during the test. The electrodermal responses to the stimuli represent an increase in the conductance due to the increased number of filled sweat ducts that act as conductors through the electrically highly resistant epidermis. Each patient is followed up for one year in order to assess the occurrence of

  20. European clinical guidelines for hyperkinetic disorder -- first upgrade

    NARCIS (Netherlands)

    Taylor, E.; Dopfner, M.; Sergeant, J.A.; Asherson, P.; Banaschewski, T.; Coghill, D.; Danckaerts, M.; Rothenberger, A.; Sonuga-Barke, E.; Steinhausen, H.C.; Zuddas, A.

    2004-01-01

    BACKGROUND: The validity of clinical guidelines changes over time, because new evidence-based knowledge and experience develop. OBJECTIVE: Hence, the European clinical guidelines on hyperkinetic disorder from 1998 had to be evaluated and modified. METHOD: Discussions at the European Network for

  1. Medical research in emergency research in the European Union member states: tensions between theory and practice.

    Science.gov (United States)

    Kompanje, Erwin J O; Maas, Andrew I R; Menon, David K; Kesecioglu, Jozef

    2014-04-01

    In almost all of the European Union member states, prior consent by a legal representative is used as a substitute for informed patient consent for non-urgent medical research. Deferred (patient and/or proxy) consent is accepted as a substitute in acute emergency research in approximately half of the member states. In 12 European Union member states emergency research is not mentioned in national law. Medical research in the European Union is covered by the Clinical Trial Directive 2001/20/EC. A proposal for a regulation by the European Commission is currently being examined by the European Parliament and the Council and will replace Directive 2001/20/EC. Deferred patient and/or proxy consent is allowed in the proposed regulation, but does not fit completely in the practice of emergency research. For example, deferred consent is only possible when legal representatives are not available. This criterion will delay inclusion of patients in acute life-threatening conditions in short time frames. As the regulation shall be binding in its entirety in all member states, emergency research in acute situations is still not possible as it should be.

  2. Ageism and clinical research.

    Science.gov (United States)

    Briggs, R; Robinson, S; O'Neill, D

    2012-10-01

    Despite being the most significant consumers of health care resources and medications worldwide, recent international research has highlighted the under-representation of older participants from clinical trials. This creates problems for physicians as the patients seen in clinical practice are not representative of those on which medical treatments and interventions have been trialled, and we need to consider whether results (both negative and positive) from these trials are applicable to these patients. Our aim was to gauge whether exclusion of older people was prevalent in research proposals submitted to Dublin teaching hospitals. We audited all clinical research proposals submitted to the Research Ethics committee (REC) covering the teaching hospitals attached to Trinity College Dublin (TCD) from July 2008 to July 2011 inclusive, recording exclusion of patients based on an arbitrary upper age limit. Of the 226 relevant trials studied, 31(13.7%) excluded participants based solely on an arbitrary upper age limit. 22 (9.8%) of the relevant trials were submitted by geriatricians, none of which excluded patients based solely on age. Over 50% (12 of 22) trials submitted by neurology/psychiatry excluded patients based on an upper age limit. The mean upper age limit used over all trials as a cut-off was 69.2 years of age. As well as this, the majority of the remaining trials also contained other exclusion criteria, especially those based on cognitive function which further limited participation of older people. While we found that a significant proportion of clinical trials submitted to the TCD REC still excluded patients based arbitrarily on an upper age limit, participation rates of older people seem to be higher in this Irish centre than that seen in international trials. Significant room for improvement still remains however and there needs to be a promotion of greater awareness of the need for developing, testing and licensing medicines so that it mirrors the

  3. A European Research Area; Un espacio de investigacion Europeo

    Energy Technology Data Exchange (ETDEWEB)

    Caro, R.

    2001-07-01

    This article is a summary of the presentation of the European Commissioner, Philippe Busquen, to the European Parliament (beginning of year 2000) with the proposal and method for a revival of the Research and Development in this wider sense in the European Union. The starting point of his thesis is that Europe performs less, and more disorderly, activities in this field that her main competitors. USA and Japan. His basic proposal is a larger coordination among the european research projects, with a previous phase of informatics intoxicator among the european research centres and the cross-linked participation, real of virtual in the experiments and projects. (Author)

  4. ESMN / European Solar Physics Research Area

    NARCIS (Netherlands)

    Rutten, R.J.

    1999-01-01

    I briefly present the European Solar Magnetometry Network as a contemporary example of solar physics collaboration across European borders,and I place it in larger-scale context by discussing the past and future of Europe-wide solar physics organization.Solar physics from space is inherently

  5. Changing European Governance, Changing Research and Innovation

    DEFF Research Database (Denmark)

    Borrás, Susana

    This chapter examines two fundamental dimensions of the changing European governance, namely the coordination of national policies and the changes in membership (accession of Central and Eastern European Countries in the mid-2000, and of Brexit in late 2010s). In particular this chapter looks...

  6. A European Perspective on Security Research

    Science.gov (United States)

    Liem, Khoen; Hiller, Daniel; Castex, Christoph

    Tackling the complexity and interdependence of today's security environment in the globalized world of the 21st century is an everlasting challenge. Whereas the end of the Cold War presented a caesura of global dimension for the political and economic architecture and a realignment of power distribution and international relations between former adversaries, September 11th of 2001 may be seen as another caesura. Since then, specifically among countries of the Western hemisphere, traditional security paradigms and theories have been critically questioned and the different security cultures and perceptions have resulted in diverse security and defence policies as well as in security research efforts of individual countries. Consensus, it seems, exists on the question of what the threats are that our modern interconnected societies are facing. Whether looking at international terrorism, organized crime, climate change, the illegal trafficking of goods and people or naturally caused catastrophes, these phenomena all have in common that they are in most cases of transnational nature. Formerly existing dividing lines between internal and external security continue to fade, presenting an enormous challenge for those in charge of designing security policy and even more so for the various institutions safeguarding European security. That is why dissent often revolves around the question on how to get hold of these complex problems. Geographic location, cultural background, ethical make-up of society as well as relations with neighbouring countries are all important aspects to be considered when assessing the security culture and policy of individual countries.

  7. The European Federation of Clinical Chemistry and Laboratory Medicine.

    Science.gov (United States)

    Hallworth, Mike

    2010-01-01

    Laboratory medicine is at the heart of modern health care and diagnosis and effective treatment of patients is impossible without high-quality bioanalytical services. The European Federation of Clinical Chemistry and Laboratory Medicine is a professional federation working to ensure high standards across the discipline in all European countries. This article describes our work in science, education and professional development.

  8. The European Prader-Willi Syndrome Clinical Research Database: An Aid in the Investigation of a Rare Genetically Determined Neurodevelopmental Disorder

    Science.gov (United States)

    Holland, A.; Whittington, J.; Cohen, O.; Curfs, L.; Delahaye, F.; Dudley, O.; Horsthemke, B.; Lindgren, A. -C.; Nourissier, C.; Sharma, N.; Vogels, A.

    2009-01-01

    Background: Prader-Willi Syndrome (PWS) is a rare genetically determined neurodevelopmental disorder with a complex phenotype that changes with age. The rarity of the syndrome and the need to control for different variables such as genetic sub-type, age and gender limits clinical studies of sufficient size in any one country. A clinical research…

  9. Failures in clinical trials in the European Union: lessons from the Polish experience.

    Science.gov (United States)

    Waligora, Marcin

    2013-09-01

    When discussing the safety of research subjects, including their exploitation and vulnerability as well as failures in clinical research, recent commentators have focused mostly on countries with low or middle-income economies. High-income countries are seen as relatively safe and well-regulated. This article presents irregularities in clinical trials in an EU member state, Poland, which were revealed by the Supreme Audit Office of Poland (the NIK). Despite adopting many European Union regulations, including European Commission directives concerning Good Clinical Practice, these irregularities occurred. Causes as well as potential solutions to make clinical trials more ethical and safer are discussed.

  10. Key issues in European food science research: a review of the European Food Science Day 2009

    NARCIS (Netherlands)

    Spichtinger, D.; Pongratz, I.; Jonsson, J.; Braun, S.; Colmer, C.; Poms, R.; Smith, R.; Ashwell, M.; Demeneix, B.; Skerfving, S.; Poel, van der W.H.M.; Laag, van der P.; Kuck, M.; Warkup, C.

    2010-01-01

    This paper is a report on the European Food Science Day (Brussels, 18 November 2009, organized by the CommNet network of food science communicators) and its outcomes. The article presents FP 7 as a key funding mechanism in European food and nutrition research and it puts research in this sector in a

  11. Ethical aspects of clinical research with minors.

    Science.gov (United States)

    Bos, Wendy; Tromp, Krista; Tibboel, Dick; Pinxten, Wim

    2013-07-01

    Over the past decades, clinical research has increasingly been subjected to ethical requirements and legal regulation. The specific focus of ethical and legal frameworks on competent adults (which serve as the paradigmatic research subject), however, has created an ambivalent attitude towards pediatric clinical research. On one hand, minors are regarded as a vulnerable population that deserves additional protection against the risks and burdens involved in clinical research. On the other hand, the population of minors should not be denied (or not get timely) access to the benefits of clinical research. In this paper, we will explore the legal regulation and ethical guidance that currently governs pediatric clinical research in the European Union and discuss the future challenges in this field. In addition, we will discuss major ethical concerns in pediatric clinical research, with a focus on the acceptability of research risks and the informed consent process. In the discussion, we will address key concerns in both regulating pediatric clinical research and implementing ethical and legal requirement in the actual pediatric research conduct.

  12. The Organization of European Cancer Institute Pathobiology Working Group and its support of European biobanking infrastructures for translational cancer research.

    Science.gov (United States)

    Riegman, Peter H J; de Jong, Bas W D; Llombart-Bosch, Antonio

    2010-04-01

    Today's translational cancer research increasingly depends on international multi-center studies. Biobanking infrastructure or comprehensive sample exchange platforms to enable networking of clinical cancer biobanks are instrumental to facilitate communication, uniform sample quality, and rules for exchange. The Organization of European Cancer Institutes (OECI) Pathobiology Working Group supports European biobanking infrastructure by maintaining the OECI-TuBaFrost exchange platform and organizing regular meetings. This platform originated from a European Commission project and is updated with knowledge from ongoing and new biobanking projects. This overview describes how European biobanking projects that have a large impact on clinical biobanking, including EuroBoNeT, SPIDIA, and BBMRI, contribute to the update of the OECI-TuBaFrost exchange platform. Combining the results of these European projects enabled the creation of an open (upon valid registration only) catalogue view of cancer biobanks and their available samples to initiate research projects. In addition, closed environments supporting active projects could be developed together with the latest views on quality, access rules, ethics, and law. With these contributions, the OECI Pathobiology Working Group contributes to and stimulates a professional attitude within biobanks at the European comprehensive cancer centers. Improving the fundamentals of cancer sample exchange in Europe stimulates the performance of large multi-center studies, resulting in experiments with the desired statistical significance outcome. With this approach, future innovation in cancer patient care can be realized faster and more reliably.

  13. Flood Risk Research and Warning Tools at the European Scale

    NARCIS (Netherlands)

    Roo, A.P.J. de; Thielen, J.; Feyen, L.; Burek, P.; Salamon, P.

    2012-01-01

    The floods in the rivers Meuse and Rhine in 1993 and 1995 made the European Commission realize that also at Commission level further research on floods – especially in transboundary river catchments - was necessary. This led to the start of a dedicated research project on floods at the European

  14. Manifesto for a European Anxiety Disorders Research Network

    NARCIS (Netherlands)

    Baldwin, David S.; Allgulander, Christer; Altamura, Alfredo Carlo; Angst, Jules; Bandelow, Borwin; den Boer, Johan; Boyer, Patrice; Davies, Simon; dell'Osso, Bernardo; Eriksson, Elias; Fineberg, Naomi; Fredrikson, Mats; Herran, Andres; Maron, Eduard; Metspalu, Andres; Nutt, David; van der Wee, Nic; Luis Vazquez-Barquero, Jose; Zohar, Joseph

    Despite the size, burden and costs of anxiety disorders, many patients remain unrecognised, and the effectiveness of evidence-based interventions in routine clinical practice can be disappointing. The European College of Neuropsychopharmacology (ECNP) has established the ECNP Network Initiative

  15. The industrialization of clinical research.

    Science.gov (United States)

    Rettig, R A

    2000-01-01

    Recent controversies over the protection of human subjects, payment of physicians for recruiting patients to clinical trials, Food and Drug Administration (FDA) removal of approved drugs from the market, and reporting of results of clinical trials have highlighted important facets of clinical research. Less visible has been the industrialization of clinical research, and especially of clinical trials, that is, its emergence as a "line of business" of substantial magnitude and rapid growth. The growth of drug-industry outsourcing of clinical trials and the concomitant rise of a contract research industry are described in this paper, which argues for greater transparency in the conduct of both publicly and privately sponsored clinical trials.

  16. Clinical intervention research in nursing.

    Science.gov (United States)

    Forbes, Angus

    2009-04-01

    As a healthcare profession nursing has a duty to develop practices that contribute to the health and well being of patients. The aim of this paper is to discuss current issues in clinical research within nursing. The paper defines clinical interventions research as a theoretically based, integrated and sequential approach to clinical knowledge generation. The paper provides specific criteria for defining a clinical intervention together with an overview of the stages involved in clinical research from problem identification to implementing knowledge in practice. The paper also explored the extent to which nursing research was focussed on clinical issues, through a snapshot review of all the original research papers in Europe's three leading nursing research journals. In total of 517 different papers were included and classified in the review. Of these 88% (n=455) were classified as non-clinical intervention and 12% (n=62) as clinical intervention studies. The paper examined the intervention studies in detail examining: the underpinning theory; linkage to previous (pre-clinical) work; evidence of granularity; protocol clarity (generalisable and parsimonious); the phase of knowledge development; and evidence of safety (adverse event reporting). The paper discusses some of the shortcomings of interventions research in nursing and suggests a number of ideas to help address these problems, including: a consensus statement on interventions research in nursing; a register of nursing intervention studies; the need for nursing to develop clinical research areas in which to develop potential interventions (nursing laboratories); and a call for nursing researchers to publish more research in nursing specific journals.

  17. CERN - European Organization for Nuclear Research

    CERN Multimedia

    Holmes, Addison

    2004-01-01

    Why do we have mass? What is the universe made of and how old is it? Why do two particles arat seem to instantaneously react to each other? Fifty years ago, these and many others questions made physics the field for any mathermatical inquiring mind and it was the US that led the field. For this reason, amongs others, 11 European countries initiated a project, under the auspices of UNESCO, to assemble their collective resources and minds to explore the universe at the sub-atommic level (2 pages)

  18. Clinical Trials in Vision Research

    Science.gov (United States)

    ... Clinical Trials in Vision Research Booklet for Nook, iPad and iPhone (EPUB - 1.6MB) Download the Clinical ... NEI Office of Science Communications, Public Liaison, and Education. Technical questions about this website can be addressed ...

  19. European legislation impedes critical care research and fails to protect patients' rights

    DEFF Research Database (Denmark)

    Berg, Ronan M G; Møller, Kirsten; Rossel, Peter Johannes Hancke

    2011-01-01

    The European Clinical Trials Directive requires an informed consent from the patient or a proxy in drug trials. Although informed consent is a valuable tool to protect patients' rights in clinical trials, this requirement largely impedes research in critical care settings, and if pursued in this ...

  20. SPECIAL ARTICLE Clinical research

    African Journals Online (AJOL)

    creativity can be taught, and that the author can teach. Since my only virtUe is that I have been involved in research for a quarter of a century and there is a reason- able chance that I am older than those who might read this 'advice', I have decided to produce this manuscript in the form of 'a message to a young researcher'.

  1. Clinical end points for drug treatment trials in BCR-ABL1-negative classic myeloproliferative neoplasms: consensus statements from European LeukemiaNET (ELN) and Internation Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT).

    Science.gov (United States)

    Barosi, G; Tefferi, A; Besses, C; Birgegard, G; Cervantes, F; Finazzi, G; Gisslinger, H; Griesshammer, M; Harrison, C; Hehlmann, R; Hermouet, S; Kiladjian, J-J; Kröger, N; Mesa, R; Mc Mullin, M F; Pardanani, A; Passamonti, F; Samuelsson, J; Vannucchi, A M; Reiter, A; Silver, R T; Verstovsek, S; Tognoni, G; Barbui, T

    2015-01-01

    The discovery of somatic mutations, primarily JAK2V617F and CALR, in classic BCR-ABL1-negative myeloproliferative neoplasms (MPNs) has generated interest in the development of molecularly targeted therapies, whose accurate assessment requires a standardized framework. A working group, comprised of members from European LeukemiaNet (ELN) and International Working Group for MPN Research and Treatment (IWG-MRT), prepared consensus-based recommendations regarding trial design, patient selection and definition of relevant end points. Accordingly, a response able to capture the long-term effect of the drug should be selected as the end point of phase II trials aimed at developing new drugs for MPNs. A time-to-event, such as overall survival, or progression-free survival or both, as co-primary end points, should measure efficacy in phase III studies. New drugs should be tested for preventing disease progression in myelofibrosis patients with early disease in randomized studies, and a time to event, such as progression-free or event-free survival should be the primary end point. Phase III trials aimed at preventing vascular events in polycythemia vera and essential thrombocythemia should be based on a selection of the target population based on new prognostic factors, including JAK2 mutation. In conclusion, we recommended a format for clinical trials in MPNs that facilitates communication between academic investigators, regulatory agencies and drug companies.

  2. Research Methods in European Union Studies

    DEFF Research Database (Denmark)

    Research methods and designs from the social sciences and beyond can, and should, be applied in research directed at EU affairs. The purpose of this edited collection is twofold: (1) to provide a state-of-the-art examination of social science research methods in EU studies and (2) to provide...... innovative guidelines to the advancement of more inclusive and empirically sensitive research methods in EU studies....

  3. Research Methods in European Union Studies

    DEFF Research Database (Denmark)

    Research methods and designs from the social sciences and beyond can, and should, be applied in research directed at EU affairs. The purpose of this edited collection is twofold: (1) to provide a state-of-the-art examination of social science research methods in EU studies and (2) to provide inno...

  4. Protecting animals and enabling research in the European Union

    DEFF Research Database (Denmark)

    Olsson, I. Anna S.; Pinto da Silva, Sandra; Townend, David

    2016-01-01

    In 1986, European Directive 86/609/EEC, regulating the use of animals in research, was one of the first examples of common legislation to set standards for animal protection across the Member States of the former European Economic Community, now the European Union, with the aim of securing a level...... European playing field. Starting in 2002, a process of revising European animal experimentation legislation was undertaken, with one of its key aims being to ensure high standards of welfare for laboratory animals across Europe. This resulted in Directive 2010/63/EU, which has regulated this activity...... objectives of the directive, particularly with a focus on securing the same high standards of animal protection across member countries. The analysis focuses on three separate issues: (1) minimum standards for laboratory animal housing and care, (2) restrictions on the use of certain animal species, and (3...

  5. The European Research Infrastructures of the ESFRI Roadmap in Biological and Medical Sciences: status and perspectives

    Directory of Open Access Journals (Sweden)

    Alessia Calzolari

    2014-06-01

    Full Text Available INTRODUCTION. Since 2002, the European Strategy Forum on Research Infrastructures identified the needs for Research Infrastructures (RIs in Europe in priority fields of scientific research and drafted a strategic document, the ESFRI Roadmap, defining the specific RIs essential to foster European research and economy. The Biological and Medical Sciences RIs (BMS RIs were developed thanks to the active participation of many institutions in different European member states associated to address the emerging needs in biomedicine and, among these, the Italian National Institute of Health (ISS, in virtue of its role in public health and research, has been specifically involved in the national development and implementation of three RIs: the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI, the European Advanced Translational Research Infrastructure in Medicine (EATRIS and the European Clinical Research Infrastructures Network (ECRIN. AIM. This article outlines the design and development of these RIs up to the recent achievement of the ERIC status, their importance in the Horizon 2020 programme and their societal and economic potential impact, with special attention to their development and significance in Italy. CONCLUSIONS. The ISS plays a unique role in fostering a coordinated participation of excellence Italian institutes/facilities to different European biomedical RIs, thus contributing to health innovation, healthcare optimization, and healthcare cost containment.

  6. Integrating clinical research into clinical decision making

    Directory of Open Access Journals (Sweden)

    Mark R Tonelli

    2011-01-01

    Full Text Available Evidence-based medicine has placed a general priority on knowledge gained from clinical research for clinical decision making. However, knowledge derived from empiric, population-based research, while valued for its ability to limit bias, is not directly applicable to the care of individual patients. The gap between clinical research and individual patient care centers on the fact that empiric research is not generally designed to answer questions of direct relevance to individual patients. Clinicians must utilize other forms of medical knowledge, including pathophysiologic rationale and clinical experience, in order to arrive at the best medical decision for a particular patient. In addition, clinicians must also elucidate and account for the goals and values of individual patients as well as barriers and facilitators of care inherent in the system in which they practice. Evidence-based guidelines and protocols, then, can never be prescriptive. Clinicians must continue to rely on clinical judgment, negotiating potentially conflicting warrants for action, in an effort to arrive at the best decision for a particular patient.

  7. Research Strategies in European Union Studies

    DEFF Research Database (Denmark)

    Manners, Ian James; Lynggaard, Kennet; Löfgren, Karl

    2015-01-01

    The contributing chapters of this book all illustrate the richness and diversity of problem-driven research in EU studies. This concluding chapter draws together the insights of this rich diversity in order to move the study of research strategies beyond the dichotomies of the past towards a new ...

  8. Leading European Research Organisations Join Forces in EIROFORUM

    Science.gov (United States)

    2001-05-01

    Since the early 1950s, a number of powerful research infrastructures and laboratories which are used by an extensive network of scientists have been developed and deployed within Europe by European Intergovernmental Research Organisations (EIRO). Together, they represent European spearheads in some of the most crucial basic and applied research fields. Seven of these organisations have set up a co-ordination and collaboration group ( EIROFORUM ) with their top executives (Directors General or equivalent) as members. They include CERN (particle physics), EMBL (molecular biology), ESA (space activities), ESO (astronomy and astrophysics), ESRF (synchrotron radiation), ILL (neutron source) and EFDA (fusion). A primary goal of EIROFORUM is to play an active and constructive role in promoting the quality and impact of European Research. In particular, the group will be a basis for effective, high-level inter-organisational interaction and co-ordination. It will mobilise its substantial combined expertise in basic research and in the management of large international projects for the benefit of European research and development. This will be possible by exploiting the existing intimate links between the member organisations and their respective European research communities. According to the EIROFORUM Charter , the main aims of the collaboration are to: 1. Encourage and facilitate discussions among its members on issues of common interest, which are relevant to research and development. 2. Maximise the scientific return and optimise the use of resources by sharing relevant developments and results, whenever feasible. 3. Co-ordinate the education and outreach activities of the organisations, including technology transfer and public understanding. 4. Take an active part, in collaboration with other European scientific organisations, in taking a forward-look at promising and/or developing research directions and priorities, in particular in relation to new large

  9. Arguing for a Contextual Approach to European Media Education Research

    Directory of Open Access Journals (Sweden)

    Hans Martens

    2012-12-01

    Full Text Available In this article, we focus on how various historical, contextual, and idiosyncratic factors shape the aims and methods of current European media educational practice. We start by briefly situating the history of European media education research and policymaking. We then discuss in more detail three important strands of media literacy initiatives within the Flemish Community (Belgium. While each of these diverging types of media education partly mirrors broader trends in European media research and policymaking, their aims and instructional methods also reveal the specificity of the Flemish media literacy context. In our discussion, we draw upon these findings to pinpoint a number of key determinants which may help to better understand similarities and differences within the European Union.

  10. AIDA – pushing the boundaries of European particle detector research

    CERN Multimedia

    Naomi Gilraen Wyles

    2011-01-01

    AIDA (Advanced European Infrastructures for Detectors at Accelerators), a new project co-funded by the European Union and worth a total of 26 million euros, will be officially launched at CERN next week. The kick-off meeting will take place on 16-18 February, during which Europe-wide detector physicists will come together to begin work on detector infrastructure developments for future particle physics experiments.   Coordinated by CERN, AIDA involves more than 80 institutes and laboratories from 23 countries as beneficiaries or associate partners (the full list can be found here). This four-year project will receive 8 million euros from the European Commission's FP7 Research Infrastructures programme. AIDA will develop facilities covering the four main goals identified by the European Strategy for Particle Physics. These are the LHC upgrade, Linear Colliders, Neutrino facilities and Super-B factories. These facilities will also be available for other researchers in the fields of nuclear and par...

  11. A syllabus for research ethics committees: training needs and resources in different European countries.

    Science.gov (United States)

    Cairoli, Ester; Davies, Hugh T; Helm, Jürgen; Hook, Georg; Knupfer, Petra; Wells, Frank

    2012-03-01

    This paper reports a European Forum for Good Clinical Practice workshop held in 2011 to consider a research ethics committee training syllabus, subsequent training needs and resources. The syllabus that was developed was divided into four competencies: committee working; scientific method; ethical analysis and the regulatory framework. Appropriate training needs for each, with possible resources, were discussed. Lack of funding for training was reported as a major problem but affordable alternatives were debated. Strengths and weaknesses of this approach were discussed and the resultant proposal will be disseminated through the European Forum for Good Clinical Practice and the research ethics committees of member states.

  12. European consensus conference on faecal microbiota transplantation in clinical practice.

    Science.gov (United States)

    Cammarota, Giovanni; Ianiro, Gianluca; Tilg, Herbert; Rajilić-Stojanović, Mirjana; Kump, Patrizia; Satokari, Reetta; Sokol, Harry; Arkkila, Perttu; Pintus, Cristina; Hart, Ailsa; Segal, Jonathan; Aloi, Marina; Masucci, Luca; Molinaro, Antonio; Scaldaferri, Franco; Gasbarrini, Giovanni; Lopez-Sanroman, Antonio; Link, Alexander; de Groot, Pieter; de Vos, Willem M; Högenauer, Christoph; Malfertheiner, Peter; Mattila, Eero; Milosavljević, Tomica; Nieuwdorp, Max; Sanguinetti, Maurizio; Simren, Magnus; Gasbarrini, Antonio

    2017-04-01

    Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  13. Activities in the ATLAS Experiment during European Researchers Night 2010.

    CERN Multimedia

    Claudia Marcelloni

    2010-01-01

    On 24 September 2010 from 5 p.m. to 1 a.m., European Researchers Night will give some 100 young students from local schools the opportunity to sit side by side with scientists and operators in the LHC control rooms. At the same time, a live webcast will connect CERN with various institutes around Europe participating in the Being a European Scientist Today (BEST) project.

  14. [American and European legislation on bioethics evaluation of clinical experimentation].

    Science.gov (United States)

    Scuderi, G

    1998-01-01

    This paper describes the existing legislation for evaluating the bioethics of clinical trials (drug studies conducted on humans after completion of drug testing on animals). The legislation is presented in chronologic order; thus that of the United States is presented first, followed by a description of the European Union legislation, which includes a brief comment on Italian legislation. The rationale for informed consent and the specific requirements are addressed. Ethical committees are discussed in terms of their membership, responsibilities, and methods of revision. The paper concludes with a comparison between the USA and the European Union legislations.

  15. European Mixed Forests: definition and research perspectives

    Directory of Open Access Journals (Sweden)

    Andres Bravo-Oviedo

    2014-12-01

    Full Text Available Aim of study: We aim at (i developing a reference definition of mixed forests in order to harmonize comparative research in mixed forests and (ii review the research perspectives in mixed forests.Area of study: The definition is developed in Europe but can be tested worldwide.Material and Methods: Review of existent definitions of mixed forests based and literature review encompassing dynamics, management and economic valuation of mixed forests.Main results: A mixed forest is defined as a forest unit, excluding linear formations, where at least two tree species coexist at any developmental stage, sharing common resources (light, water, and/or soil nutrients. The presence of each of the component species is normally quantified as a proportion of the number of stems or of basal area, although volume, biomass or canopy cover as well as proportions by occupied stand area may be used for specific objectives. A variety of structures and patterns of mixtures can occur, and the interactions between the component species and their relative proportions may change over time.The research perspectives identified are (i species interactions and responses to hazards, (ii the concept of maximum density in mixed forests, (iii conversion of monocultures to mixed-species forest and (iv economic valuation of ecosystem services provided by mixed forests.Research highlights: The definition is considered a high-level one which encompasses previous attempts to define mixed forests. Current fields of research indicate that gradient studies, experimental design approaches, and model simulations are key topics providing new research opportunities.Keywords: COST Action; EuMIXFOR; mixed-species forests; admixtures of species.

  16. The changing role for European research libraries

    OpenAIRE

    Ayris, P.

    2015-01-01

    This presentation looks at Open Access to Publications, Research Data Management and the Science 2.0 (Open Science) agendas in Europe. It analyses the current British policy position on Open Access to publications and looks at the costs of these approaches. In terms of Research Data Management, the presentation looks at UCL’s new EU-funded LEARN project and the implications of the new Hague Declaration on Knowledge Discovery in the Digital Age. The paper argues that facts and data should not ...

  17. MR spectroscopy in clinical research

    DEFF Research Database (Denmark)

    Henriksen, O

    1994-01-01

    MR spectroscopy (MRS) offers unique possibilities for non-invasive evaluation of biochemistry in vivo. During recent years there has been a growing body of evidence from clinical research studies on human beings using 31P and 1H MRS. The results indicate that it is possible to evaluate phosphorous...... for non-invasive follow-up of treatment. Taken together, the evidence obtained so far certainly shows some trends for clinical applications of MRS. Methods are now available for the clinical research necessary for establishing routine clinical MRS examinations....

  18. European network for research in global change (ENRICH)

    Energy Technology Data Exchange (ETDEWEB)

    Ghazi, A. [European Commission, Bruxelles (Belgium). DG XII/JRC

    1995-12-31

    While approaching the beginning of the twenty first century, the scientific community is faced with the formidable tasks of monitoring and detecting, understanding and predicting changes in the Earth System and its interactions with human beings. A crucial challenge is to make scientific research results accessible and usable for those involved in the decision making process related to the concept of Sustainable Development. Major international scientific programmes under the umbrella of ICSU, such as the IGBP and WCRP, are dealing with these issues. Although there exist many well developed global change research programmes in several European countries and effective collaboration networks between research institutes, there is an urgent need for overall communication with a view to promoting wider international links ensuring complementarity, synergy and coherence. Recognizing the importance of promoting coherence in research and utilising research results for various European Union (EU) policies, the European Commissioner responsible for Science, Research and Development wrote in March 1992 to all the EU Research Ministers to propose an initiative in this domain. In a rapid response, a group of Senior Experts from the EU Member States was set up in April 1992. This Group established a Task Force to develop the concept of the European Network for Research In Global CHange (ENRICH) which was approved in July 1993

  19. CMS Virtual Visits @ European Researchers Night, 30 September 2016

    CERN Multimedia

    Lapka, Marzena

    2016-01-01

    CMS hosted four virtual visits during European Researchers Night. Audience from Greece (NCRS Demokritos, Athens), Poland (University of Science and Technology in Krakow), Italy (Psiquadro in Perugia & INFN in Pisa) and Portugal (Planetarium Calouste Gulbenkian, organised by LIP) had an occasion to converse with CMS researchers and "virtually" visit CMS Control Room and underground facilities.

  20. Integrating advance research directives into the European Legal Framework

    NARCIS (Netherlands)

    Andorno, R. (Roberto); Gennet, E. (Eloïse); K.R. Jongsma (Karin); Elger, B. (Bernice)

    2016-01-01

    textabstractThe possibility of using advance directives to prospectively consent to research participation in the event of dementia remains largely unexplored in Europe. Moreover, the legal status of advance directives for research is unclear in the European regulations governing biomedical

  1. The Creation of the European Social Work Research Association

    Science.gov (United States)

    Taylor, Brian J.; Sharland, Elaine

    2015-01-01

    As the social work profession matures, the need for robust knowledge becomes more pressing. Greater coordination is required to develop the research community and an infrastructure to support this nationally and internationally. This article discusses the foundation, in 2014, of the European Social Work Research Association and its roots in the…

  2. Organising Continuity and Quality of the European Educational Research Association

    Science.gov (United States)

    Jochems, Wim; Wubbels, Theo

    2014-01-01

    Research associations tend to be voluntary by nature and therefore unstable in character, and thus are subject to threat for their continuity. History has shown that the European Educational Research Association (EERA) is not an exception to this rule. Because EERA Council and the board members are volunteers with limited time, experience and…

  3. A Measure of Excellence of Young European Research Council Grantees

    Science.gov (United States)

    Arevalo, Javier

    2017-01-01

    Bibliometric benchmarking can be an aid to researchers pondering whether to apply for competitive grants. In this paper, the highly prestigious grants offered by the European Research Council to young scientists of any nationality were scrutinized. The analysis of the 2014-2015 data indicates that over 75% of life science grantees in the starting…

  4. Perspectives for food research and European collaboration in the European Research Area and the new Framework Programme.

    Science.gov (United States)

    Breslin, L

    2001-08-01

    Since 1987, successive framework programmes have contributed to strengthen European food research through the establishment of networks between research institutions, universities and companies from various European countries. In the FAIR programme (1994-1998), 118 research projects comprising nearly 1,000 participants from the European Union and Associated States have been supported in the food area with a European funding of about [symbol: see text] 108 million. Within the Quality of Life and Management of Living Resources programme (1998-2002), food research is mostly supported within the key action 'food, nutrition and health' with a budget of [symbol: see text] 290 million. After the first four deadlines, 735 eligible research proposals have already been received. Further to their evaluation by a panel of independent experts, 108 proposals have been funded or selected for funding representing a total contribution of about [symbol: see text] 168 million. Among those, several clusters of projects are now running on important topics such as probiotics, coeliac diseases, mycotoxins, GMO, safety and food for the elderly. In addition, technology stimulation measures are largely benefiting SMEs to foster their innovation potential. In January 2000, the European Commission adopted a Communication entitled "Towards the European Research Area (ERA)" with the objective to contribute to developing better framework conditions for research in Europe. On 21 February 2001, the Commission adopted proposals to be submitted to the European Parliament and Council for the next framework programme for research and innovation (2002-2006). The new framework programme that is becoming one of the financial instruments of the ERA aims at catalysing the integration of European research by: strengthening of links between the Community research effort and national and regional research policies; concentrating on a limited number of priority fields or research to which activities at the

  5. A Survey of European Robotics Research.

    Science.gov (United States)

    1984-01-27

    The material and operations of the US Navy. information in this report is based on Material will be influenced first--by on-site visits to 21 of the...in Table I these areas will make the acquisition were chosen from the results of a and maintenance of the materials neces- literature review...analysis, and lic actuators. Dr. Burckhardt expected gray level image processing techniques. future robot research in gray scale The Laboratorio per

  6. Scintilla European project, the successful research results

    Energy Technology Data Exchange (ETDEWEB)

    Sannie, G.; Kondrasov, V.; Corre, G.; Boudergui, K.; Perot, B.; Carasco, C.; Montemont, G. [Commissariat a l' energie atomique et aux energies alternatives, Saclay, Cadarache, Grenoble (France); Peerani, P.; Carrapico, C.; Tomanin, A.; Rosas, F.; Caviglia, M.; Eklund, G.; Tagziria, H. [European Commission, Joint Research Centre, ITU, Nuclear Security Unit, Ispra (Italy); Friedrich, H.; Chmel, S. [Fraunhofer-Institut fuer Naturwissenschaftlich - Technische Trendanalysen - INT, Euskirchen (Germany); De Vita, R.; Manchini, E.; Pavan, M. [Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Genova (Italy); Grattarola, M.; Botta, E. [Ansaldo Nucleare S.P.A, Genova (Italy); Kovacs, A.; Lakosi, L. [Hungarian Academy of Sciences, Centre for Energy Research, Budapest (Hungary); Baumhauer, C.; Deheuninck, T.; Haddad, E. [ARTTIC, Paris (France); Petrossian, G.; Ferragut, A. [SAPHYMO, Massy (France); Dermody, G.; Crossingham, G. [Symetrica Security Ltd, Southampton (United Kingdom)

    2015-07-01

    The Scintilla FP7 project is ended in December 2014, the fruitful results of 3 years development and tests will be presented. SCINTILLA offers the capacity to finding a reliable alternative to Helium-3 based detection systems since the gas which is predominantly used in nuclear safeguards and security applications has now become very expensive, rare and nearly unavailable. SCINTILLA benchmarks results are based on international standards. Radiation Portal tests were carried out at the Joint Research Centre (JRC) in Ispra (Italy). The scintilla project addresses few mains issues. The first is to develop neutron detectors for Radiation Portal Monitor (RPM) and the second is the need of new wearable integrated solutions for Spectrometric Personal Radiation Monitor (SPRM). The partners which provide technical systems of the scintilla project are INFN-ANSALDO, CEA, SYMETRICA and SAPHYMO. For RPM, the objective is to find reliable alternatives to Helium-3 historical neutron detector and provide technical solutions which cope with tests for reliable mobile and cost effective. For Spectrometric Personal Radiation Monitor (SPRM), SCINTILLA is innovating in technology areas that offer complementary capabilities for detecting and identifying gamma, Two CZT (Cadmium Zinc Telluride) addressing contexts of used by first responder technologies, one is a wearable detector and the second is a gamma camera complemented by advanced image processing technologies. (authors)

  7. Establishment of the European College of Veterinary Clinical Pathology (ECVCP) and the current status of veterinary clinical pathology in Europe

    DEFF Research Database (Denmark)

    O'Brien, P.J.; Fournel-Fleury, C.; Bolliger, Adrian Marc

    2007-01-01

    After 5 years of development, the European College of Veterinary Clinical Pathology (ECVCP)was formally recognized and approved on July 4, 2007 by the European Board of Veterinary Specialisation (EBVS), the European regulatory body that oversees specialization in veterinary medicine and which has...... approved 23 colleges. The objectives, committees, basis for membership, constitution, bylaws, information brochure and certifying examination of the ECVCP have remained unchanged during this time except as directed by EBVS. The ECVCP declared full functionality based on the following criteria: 1...... congresses and a joint journal (with the American Society for Veterinary Clinical Pathology) for communication of scientific research and information; the College also maintains a website, a joint listserv, and a newsletter; 6) collaboration in training and continuing education with relevant colleges...

  8. Bibliometric assessment of European Research Council Grantees – Comparative evaluation

    OpenAIRE

    Grøngaard, Pernille Hamburger; Isaksson, Eva; Koivula, Leena; Arévalo, Javier; Warnan, Guillaume

    2017-01-01

    Since their creation in 2007, European Research Council (ERC) Starting, Consolidator and Advanced grants have increasingly become a measure of prestige for universities. The number of ERC grantees a university gets per year can now appear as a proxy to its research excellence. As universities are putting a lot of effort to best support their applicants for ERC grants, they are looking for ways to (i) pre-select the researchers who have the best chances to have a successful application and (ii...

  9. European registration process for Clinical Laboratory Geneticists in genetic healthcare.

    Science.gov (United States)

    Liehr, Thomas; Carreira, Isabel M; Aktas, Dilek; Bakker, Egbert; Rodríguez de Alba, Marta; Coviello, Domenico A; Florentin, Lina; Scheffer, Hans; Rincic, Martina

    2017-05-01

    Tremendous progress in genetics and genomics led to a wide range of healthcare providers, genetic tests, and more patients who can benefit from these developments. To guarantee and improve the quality of genetic testing, a unified European-based registration for individuals qualified in biomedicine was realized. Therefore a Europe-wide recognition of the profession 'European registered Clinical Laboratory Geneticist (ErCLG)' based on a syllabus of core competences was established which allows for harmonization in professional education. The 'European Board of Medical Genetics division - Clinical Laboratory Geneticist' provides now since 3 years the possibility to register as an ErCLG. Applicants may be from all European countries and since this year also from outside of Europe. Five subtitles reflect the exact specialty of each ErCLG, who can reregister every 5 years. A previously not possible statistics based on ~300 individuals from 19 countries as holders of an ErCLG title provides interesting insights into the professionals working in human genetics. It could be substantiated that there are around twice as many females than males and that a PhD title was achieved by 80% of registered ErCLGs. Also most ErCLGs are still trained as generalists (66%), followed by such ErCLGs with focus on molecular genetics (23%); the remaining are concentrated either on clinical (6%), tumor (4%) or biochemical genetics (1%). In conclusion, besides MDs and genetic counselors/nurses an EU-wide recognition system for Clinical Laboratory Geneticist has been established, which strengthens the status of specialists working in human genetic diagnostics in Europe and worldwide.

  10. MR spectroscopy in clinical research

    DEFF Research Database (Denmark)

    Henriksen, O

    1994-01-01

    MR spectroscopy (MRS) offers unique possibilities for non-invasive evaluation of biochemistry in vivo. During recent years there has been a growing body of evidence from clinical research studies on human beings using 31P and 1H MRS. The results indicate that it is possible to evaluate phosphorous...... for non-invasive follow-up of treatment. Taken together, the evidence obtained so far certainly shows some trends for clinical applications of MRS. Methods are now available for the clinical research necessary for establishing routine clinical MRS examinations....... energy metabolism, loss of neurones, and lactate production in a large number of brain diseases. Furthermore, 31P and 1H MRS may be particularly clinically useful in evaluation of various disorders in skeletal muscle. In the heart 31P MRS seems at the moment the most suitable for evaluation of global...

  11. Policy Redaction Note: A positioning of the APRILAB research project in the European policy and research landscape

    DEFF Research Database (Denmark)

    Hansen, Jesper Rohr; Savini, Federico; Salet, Willem

    2013-01-01

    Policy Redaction Note: A positioning of the APRILAB research project in the European policy and research landscape.......Policy Redaction Note: A positioning of the APRILAB research project in the European policy and research landscape....

  12. A critique of emerging European legislation in the pharmaceutical industry: a clinical trials analysis.

    Science.gov (United States)

    Murray, Elizabeth; McAdam, Rodney; Burke, Moira T

    2004-01-01

    The objective of this paper is to critique emerging legislation in the pharmaceutical industry, focusing on the clinical trials sector. Possible changes are identified and discussed inrelation to their impact on phase I clinical trials conducted in the UK. It is concluded that smaller contract research organisations, which have benefited in the past from European Union legislative variation, may have resource problems in trying to cope with the changing business environment created through legislative harmonization. These SMEs must use this opportunity to seek clinical trials research partnerships in a new harmonized EU market.

  13. The importance of international collaboration for rare diseases research: a European perspective.

    Science.gov (United States)

    Julkowska, D; Austin, C P; Cutillo, C M; Gancberg, D; Hager, C; Halftermeyer, J; Jonker, A H; Lau, L P L; Norstedt, I; Rath, A; Schuster, R; Simelyte, E; van Weely, S

    2017-09-01

    Over the last two decades, important contributions were made at national, European and international levels to foster collaboration into rare diseases research. The European Union (EU) has put much effort into funding rare diseases research, encouraging national funding organizations to collaborate together in the E-Rare program, setting up European Reference Networks for rare diseases and complex conditions, and initiating the International Rare Diseases Research Consortium (IRDiRC) together with the National Institutes of Health in the USA. Co-ordination of the activities of funding agencies, academic researchers, companies, regulatory bodies, and patient advocacy organizations and partnerships with, for example, the European Research Infrastructures maximizes the collective impact of global investments in rare diseases research. This contributes to accelerating progress, for example, in faster diagnosis through enhanced discovery of causative genes, better understanding of natural history of rare diseases through creation of common registries and databases and boosting of innovative therapeutic approaches. Several examples of funded pre-clinical and clinical gene therapy projects show that integration of multinational and multidisciplinary expertize generates new knowledge and can result in multicentre gene therapy trials. International collaboration in rare diseases research is key to improve the life of people living with a rare disease.

  14. A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.

    Directory of Open Access Journals (Sweden)

    Clint Mizzi

    Full Text Available Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective.

  15. Interpreting Europe: mainstreaming gender in DG Research, European Commission

    NARCIS (Netherlands)

    Cavaghan, R.M.

    2015-01-01

    This chapter critically examines the European Commission’s work of governing. Taking the policy programme of Gender Mainstreaming (GM) as an example, Rosalind Cavaghan shows how officials in different units within DG Research interpreted their policy work and the consequences these interpretations

  16. European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines research

    NARCIS (Netherlands)

    Lehner, Thomas; Hoelscher, Michael; Clerici, Mario; Gotch, Frances; Pedneault, Louise; Tartaglia, Jim; Gray, Clive; Mestecky, Jiri; Sattentau, Quentin; van de Wijgert, Janneke; Toure, Coumba; Osmanov, Saladin; Schmidt, Reinold E.; Debre, Patrice; Romaris, Manuel; Hoeveler, Arnd; Di Fabio, Simonetta

    2005-01-01

    The European Commission (EC) has strong commitments and recognises the need to continue to ensure that HIV/AIDS research efforts receive global attention. The EC is facing this challenge in a global context and has made substantial investments together with European Developing Countries Clinical

  17. Network of Research Infrastructures for European Seismology (NERIES)

    Science.gov (United States)

    van Eck, T.; Giardini, D.; Bossu, R.; Wiemer, S.

    2008-12-01

    NERIES (Network of Research Infrastructures for European Seismology) is an Integrated Infrastructure Initiative (I3) project within the Sixth Framework Programme of the European Commission (EC). The project consortium consists of 25 participants from 13 different European countries. It is currently the largest earth science project ever funded by the EC. The goal of NERIES is to integrate European seismological observatories and research institutes into one integrated cyber-infrastructure for seismological data serving the research community, civil protection authorities and the general public. The EC provides funds for the networking and research. The participants provide the necessary hardware investments, mostly through national resources. NERIES consists of 13 subprojects (networking and research activities) and 5 facilities providing access through grants (Transnational Access). The project is coordinated by ORFEUS in close cooperation with the EMSC. The individual subprojects address different issues such as: extension of the Virtual European Broadband Seismic Network (VEBSN) from 140 to about 500 stations, implementing the core European Integrated Waveform Data Archive (EIDA) consisting of ODC-KNMI, GFZ, INGV and IPGP and a distributed archive of historical Data. Providing access to data gathered by acceleration networks within Europe and its surroundings and deploys Ocean Bottom Seismometers in coordination with relevant Ocean bottom projects like ESONET. Tot facilitate access to this diverse and distributed data NERIES invests a significant portion of its resources to implementing a portal for which a beta release is planned to be release in the autumn of 2008. The research project main goal is to produce products and tools facilitating data interpretation and analysis. These tools include a European reference (velocity) model, real-time hazard tools, shakemaps and lossmaps, site response determination software and tools, and automatic tools to manage and

  18. [Research activity in clinical biochemistry

    DEFF Research Database (Denmark)

    Jorgensen, H.L.; Larsen, B.; Ingwersen, P.

    2008-01-01

    BACKGROUND: Quantitative bibliometric measurements of research activity are frequently used, e.g. for evaluating applicants for academic positions. The purpose of this investigation is to assess research activity within the medical speciality of Clinical Biochemistry by comparing it with a matched...... Clinical Biochemistry, 57 fulfilled the inclusion criteria. Each of these 57 was matched according to medical title with two randomly chosen specialists from other specialities, totaling 114. Using Medline and the Web of Science, the number of publications and the number of citations were then ascertained....... RESULTS: 25% of the 11,691 specialists held a PhD degree or doctoral degree, DMSci, (Clinical Biochemistry: 61%). The 171 specialists included in the study had 9,823 papers in Medline and 10,140 papers in the Web of Science. The number of Medline papers per specialist was 71 for Clinical Biochemistry...

  19. Visual research in clinical education.

    Science.gov (United States)

    Bezemer, Jeff

    2017-01-01

    The aim of this paper is to explore what might be gained from collecting and analysing visual data, such as photographs, scans, drawings, video and screen recordings, in clinical educational research. Its focus is on visual research that looks at teaching and learning 'as it naturally occurs' in the work place, in simulation centres and other sites, and also involves the collection and analysis of visual learning materials circulating in these sites. With the ubiquity of digital recording devices, video data and visual learning materials are now relatively cheap to collect. Compared to other domains of education research visual materials are not widely used in clinical education research. The paper sets out to identify and reflect on the possibilities for visual research using examples from an ethnographic study on surgical and inter-professional learning in the operating theatres of a London hospital. The paper shows how visual research enables recognition, analysis and critical evaluation of (1) the hidden curriculum, such as the meanings implied by embodied, visible actions of clinicians; (2) the ways in which clinical teachers design multimodal learning environments using a range of modes of communication available to them, combining, for instance, gesture and speech; (3) the informal assessment of clinical skills, and the intricate relation between trainee performance and supervisor feedback; (4) the potentialities and limitations of different visual learning materials, such as textbooks and videos, for representing medical knowledge. The paper concludes with theoretical and methodological reflections on what can be made visible, and therefore available for analysis, explanation and evaluation if visual materials are used for clinical education research, and what remains unaccounted for if written language remains the dominant mode in the research cycle. Opportunities for quantitative analysis and ethical implications are also discussed. © 2016 John Wiley

  20. The European Research Infrastructure for Heritage Science (erihs)

    Science.gov (United States)

    Striova, J.; Pezzati, L.

    2017-08-01

    The European Research Infrastructure for Heritage Science (E-RIHS) entered the European strategic roadmap for research infrastructures (ESFRI Roadmap [1]) in 2016, as one of its six new projects. E-RIHS supports research on heritage interpretation, preservation, documentation and management. Both cultural and natural heritage are addressed: collections, artworks, buildings, monuments and archaeological sites. E-RIHS aims to become a distributed research infrastructure with a multi-level star-structure: facilities from single Countries will be organized in national nodes, coordinated by National Hubs. The E-RIHS Central Hub will provide the unique access point to all E-RIHS services through coordination of National Hubs. E-RIHS activities already started in some of its national nodes. In Italy the access to some E-RIHS services started in 2015. A case study concerning the diagnostic of a hypogea cave is presented.

  1. Research Design in the study of the European Neighbourhood Policy

    DEFF Research Database (Denmark)

    Exadaktylos, Theofanis; Lynggaard, Kennet

    2017-01-01

    This chapter deals with the pitfalls and pathways of research design aimed at the study of the European Neighbourhood Policy (ENP) and maps out the literature on questions of knowledge ambition, research ontology and epistemology, and choices of approaches to the research object. We include...... a review of traditional research designs in ENP research, through a systematic meta-analysis of a selection of the most-cited articles on the ENP. Inspired by earlier work on awareness of research design in EU studies, ENP research is categorised according to typical choices of research design in the form...... of dichotomous trade-offs. The chapter then discusses how individual contributions to this volume deal with research design challenges of the past and present innovative ways of studying the revised ENP....

  2. Assessing quality in European educational research indicators and approaches

    CERN Document Server

    Åström, Fredrik; Hansen, Antje

    2014-01-01

    Competition-based models for research policy and management have an increasing influence throughout the research process, from attracting funding to publishing results. The introduction of quality control methods utilizing various forms of performance indicators is part of this development. The authors presented in this volume deal with the following questions: What counts as ‘quality’ and how can this be assessed? What are the possible side effects of current quality control systems on research conducted in the European Research Area, especially in the social sciences and the humanities?

  3. Regulation of clinical research and bioethics in Portugal.

    Science.gov (United States)

    Carvalho, Fatima Lampreia

    2007-06-01

    This article presents an overview of the Portuguese transposition of the European Directive on Good Clinical Practice (2001/20/E) concerning scientific and academic debates on bioethics and clinical investigation. Since the Directive was transposed into Portuguese law by its National Assembly, the bureaucracy of clinical trials has been ever more complex. Despite demands for swift application processes by the Pharmaceutical industry, supported by the European Parliament, the Directive's transcription to the national law has not always delivered the expected outcome. However, this has led to an increased number of applications for clinical trials in Portuguese hospitals. In this article I revise bioethical publications and decree-laws enabling an informed appraisal of the anxieties and prospects for the implementation of the clinical trials Directive in Portugal. This article also places the European Directive in the field of sociology of bioethics, arguing that Portuguese bioethical institutions differ from those of the US, and also from Northern European counterparts. The main divergence is that those people in Portugal who claim expertise in 'legal' bioethics do not dominate either the bureaucratic structure of research or ethics committees for health. Even experts in the applied ethics field now claim that 'professional bioethicists do not exist'. The recent creation of a national Ethics Committee for Clinical Investigation (CEIC) in line with the European Directive on Good Clinical Practice (GCP) will not change the present imbalance between different professional jurisdictions in the national bioethical debate in Portugal.

  4. Bias in clinical intervention research

    DEFF Research Database (Denmark)

    Gluud, Lise Lotte

    2006-01-01

    Research on bias in clinical trials may help identify some of the reasons why investigators sometimes reach the wrong conclusions about intervention effects. Several quality components for the assessment of bias control have been suggested, but although they seem intrinsically valid, empirical...

  5. European Commission research on aircraft impacts in the atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Amanatidis, G.T.; Angeletti, G. [European Commission (CEC), Brussels (Belgium)

    1997-12-31

    Aircraft engines release in the troposphere and lower stratosphere a number of chemical compounds (NO{sub x}, CO{sub 2}, CO, H{sub 2}O, hydrocarbons, sulphur, soot, etc.) which could potentially affect the ozone layer and the climate through chemical, dynamical and radiative changes. The global amount of gases and particles emitted by current subsonic and projected supersonic aircraft fleets can be estimated, but significant uncertainties remain about the fate of these emissions in the atmosphere. The European efforts concerning these potential atmospheric impacts of aircraft emissions are conducted by the Environment and Climate Research Programme of the European Commission (EC) as well as by national programmes of the Member States of the European Union (EU). The European research activities in this field, are described, divided for practical reasons in two periods. The first includes activities supported under the 3. Framework Programme for R and D activities which covered the period from 1992 up to 1996, while the second period has started in early 1996 and is supported under the 4. Framework Programme. (R.P.) 6 refs.

  6. Stepping up Open Science Training for European Research

    Directory of Open Access Journals (Sweden)

    Birgit Schmidt

    2016-06-01

    Full Text Available Open science refers to all things open in research and scholarly communication: from publications and research data to code, models and methods as well as quality evaluation based on open peer review. However, getting started with implementing open science might not be as straightforward for all stakeholders. For example, what do research funders expect in terms of open access to publications and/or research data? Where and how to publish research data? How to ensure that research results are reproducible? These are all legitimate questions and, in particular, early career researchers may benefit from additional guidance and training. In this paper we review the activities of the European-funded FOSTER project which organized and supported a wide range of targeted trainings for open science, based on face-to-face events and on a growing suite of e-learning courses. This article reviews the approach and experiences gained from the first two years of the project.

  7. EPM - The European Facility for human physiology research on ISS.

    Science.gov (United States)

    Rieschel, Mats; Nasca, Rosario; Junk, Peter; Gerhard, Ingo

    2002-07-01

    The European Physiology Modules (EPM) Facility is one of the four major Space Station facilities being developed within the framework of ESA's Microgravity Facilities for Columbus (MFC) programme. In order to allow a wide spectrum of physiological studies in weightlessness conditions, the facility provides the infrastructure to accommodate a variable set of scientific equipment. The initial EPM configuration supports experiments in the fields of neuroscience, bone & muscle research, cardiovascular research and metabolism. The International Space Life Science Working Group (ISLSWG) has recommended co-locating EPM with the 2 NASA Human Research Facility racks.

  8. Clinical Research - Past, Present & Future

    Directory of Open Access Journals (Sweden)

    Om D Gulati

    2014-07-01

    Full Text Available Clinical pharmacology/research has a very interesting history. It started in the 40’s of the 20th century through the pioneering work of Harry Gold at Cornell University New York. Clinical research is an integral part of drug development. Drug development can be hastened by a number of new techniques with reduction in cost. In addition reverse pharmacology approaches for drug discovery have come to occupy a special place. 85% of the neutral antagonists act as inverse agonists. Inverse agonists have a distinct effect on receptor regulation as opposed to neutral antagonists.Orphan receptors constitute about 50% of the GPCRs. It is estimated that now there are nearly 175 orphan receptors after 125 having been deorphanised. Targeting these orphan receptors can lead to about the same number of ligands and antagonists thereof. Polymorphism of cytochrome P450 provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. It is estimated that such personalized P450 gene-based treatment would be relevant for 10-20% of all drug therapy.Key Words:  Clinical Pharmacology (a facet of clinical research - Human experiments for safety and efficacy; G-protein coupled receptors (GPCRs – some orphan receptors ;Strategies for drug discovery – Deorphanisation of orphan receptors, allosteric receptor sites, in-silico drug screening

  9. [Research activity in clinical biochemistry].

    Science.gov (United States)

    Jørgensen, Henrik L; Larsen, Birger; Ingwersen, Peter; Rehfeld, Jens F

    2008-09-01

    Quantitative bibliometric measurements of research activity are frequently used, e.g. for evaluating applicants for academic positions. The purpose of this investigation is to assess research activity within the medical speciality of Clinical Biochemistry by comparing it with a matched control group from other medical specialities in Denmark. A list of all physicians registered in Denmark (23,127 persons) was drawn from the database "Laeger.dk". Of these, 5,202 were generalists (not included) while 11,691 were from other specialities. Of the 126 specialists from Clinical Biochemistry, 57 fulfilled the inclusion criteria. Each of these 57 was matched according to medical title with two randomly chosen specialists from other specialities, totaling 114. Using Medline and the Web of Science, the number of publications and the number of citations were then ascertained. 25% of the 11,691 specialists held a PhD degree or doctoral degree, DMSci, (Clinical Biochemistry: 61%). The 171 specialists included in the study had 9,823 papers in Medline and 10,140 papers in the Web of Science. The number of Medline papers per specialist was 71 for Clinical Biochemistry compared to 51 for the control group. The number of citations per specialist was 1,844 for Clinical Biochemistry compared to 816 for the control group. The top ten H-indices (of which 8 were in Clinical Biochemistry) ranged from 30 to 69. Both the number of papers and the number of citations were higher for Clinical Biochemistry than for the control group. The difference was most pronounced among professors.

  10. Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8–10 October 2010

    NARCIS (Netherlands)

    Steckelings, U. Muscha; de Mey, Jo G. R.; Pinto-Sietsma, Sara-Joan; Henrion, Daniel; Unger, Thomas

    2011-01-01

    The 15th Annual Meeting of the European Council of Cardiovascular Research brought together basic and clinical scientists working in the cardiovascular field in La Colle sur Loup, France. Upfront basic and clinical research addressing the mechanisms of disease, identification of biomarkers or

  11. Radiation research within the framework programmes of the European Commission

    Energy Technology Data Exchange (ETDEWEB)

    Karaoglou, A.; Kelly, G.N.; Desmet, G.; Menzel, H.G.; Schibilla, H.; Olast, M.; Gasperini, F.; Chadwick, K.H.; Sinnave, J. [European Commission Directorate General science, Brussels (Belgium). Research and Development, Radiation Protection Research Action

    1997-09-01

    The background to the radiation protection research and training programme of the European Commission is described in the presentation. The objectives and achievements of the third framework programme are summarised together with a description of how the achievements led to the establishment of the priorities for the fourth framework programme. Indications on the preliminary prospects for the fifth framework programme, 1998-2002 are also given. (6 refs.).

  12. Eastern European Political Socialization Modeling Research: A Literature Review

    Directory of Open Access Journals (Sweden)

    Camelia Florela Voinea

    2014-01-01

    Full Text Available This paper presents empirical modeling research on political socialization of the citizens in the new Eastern European democracies. The political socialization issue offers a comparative perspective over the modeling methodologies in analytical paradigms. Eastern European political culture research has revealed features of the electoral behavior and political participation which can be identified in different degrees in all the new democracies in the area: passivity with respect to political activity of parties, elites and institutions, political apathy or lack of reaction to anti-democratic actions, skepticism or distrust in institutions, scarce participation to social movements. Several authors explain the actual political behavior of the Eastern European citizens’ and their low social and political involvement by the (political culture heritage of the communist regimes in which they lived for a long time, and which keeps shaping their political attitudes towards the state, civil society, government and institutions. Research issues in the analysis of political participation are traditionally based on statistics analyses of empirical evidence coming from public surveys. However, scarcity ofempirical data from the communist periode with regard to (political socialization, values and beliefs represent a major obstacle towards a better understanding of the historical roots of current behaviors and attitudes. Scarcity of observational data might be overcome by computational and simulation modeling.

  13. Science without meritocracy. Discrimination among European specialists in infectious diseases and clinical microbiology: a questionnaire survey

    Science.gov (United States)

    Tacconelli, Evelina; Poljak, Mario; Cacace, Marina; Caiati, Giovanni; Benzonana, Nur; Nagy, Elisabeth; Kortbeek, Titia

    2012-01-01

    Objective In 2009, in a European survey, around a quarter of Europeans reported witnessing discrimination or harassment at their workplace. The parity committee from the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) designed a questionnaire survey to investigate forms of discrimination with respect to country, gender and ethnicity among medical professionals in hospitals and universities carrying out activities in the clinical microbiology (CM) and infectious diseases (ID) fields. Design The survey consisted of 61 questions divided into five areas (sociodemographic, professional census and environment, leadership and generic) and ran anonymously for nearly 3 months on the ESCMID website. Subjects European specialists in CM/ID. Results Overall, we included 1274 professionals. The majority of respondents (68%) stated that discrimination is present in medical science. A quarter of them reported personal experience with discrimination, mainly associated with gender and geographic region. Specialists from South-Western Europe experienced events at a much higher rate (37%) than other European regions. The proportion of women among full professor was on average 46% in CM and 26% in ID. Participation in high-level decision-making committees was significantly (>10 percentage points) different by gender and geographic origin. Yearly gross salary among CM/ID professionals was significantly different among European countries and by gender, within the same country. More than one-third of respondents (38%) stated that international societies in CM/ID have an imbalance as for committee member distribution and speakers at international conferences. Conclusions A quarter of CM/ID specialists experienced career and research discrimination in European hospitals and universities, mainly related to gender and geographic origin. Implementing proactive policies to tackle discrimination and improve representativeness and balance in career among CM

  14. Science without meritocracy. Discrimination among European specialists in infectious diseases and clinical microbiology: a questionnaire survey.

    Science.gov (United States)

    Tacconelli, Evelina; Poljak, Mario; Cacace, Marina; Caiati, Giovanni; Benzonana, Nur; Nagy, Elisabeth; Kortbeek, Titia

    2012-01-01

    In 2009, in a European survey, around a quarter of Europeans reported witnessing discrimination or harassment at their workplace. The parity committee from the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) designed a questionnaire survey to investigate forms of discrimination with respect to country, gender and ethnicity among medical professionals in hospitals and universities carrying out activities in the clinical microbiology (CM) and infectious diseases (ID) fields. The survey consisted of 61 questions divided into five areas (sociodemographic, professional census and environment, leadership and generic) and ran anonymously for nearly 3 months on the ESCMID website. European specialists in CM/ID. Overall, we included 1274 professionals. The majority of respondents (68%) stated that discrimination is present in medical science. A quarter of them reported personal experience with discrimination, mainly associated with gender and geographic region. Specialists from South-Western Europe experienced events at a much higher rate (37%) than other European regions. The proportion of women among full professor was on average 46% in CM and 26% in ID. Participation in high-level decision-making committees was significantly (>10 percentage points) different by gender and geographic origin. Yearly gross salary among CM/ID professionals was significantly different among European countries and by gender, within the same country. More than one-third of respondents (38%) stated that international societies in CM/ID have an imbalance as for committee member distribution and speakers at international conferences. A quarter of CM/ID specialists experienced career and research discrimination in European hospitals and universities, mainly related to gender and geographic origin. Implementing proactive policies to tackle discrimination and improve representativeness and balance in career among CM/ID professionals in Europe is urgently needed.

  15. e-EPS News: Consultation on European Research, Innovation & Gender

    CERN Multimedia

    e-EPS

    2011-01-01

    e-EPS News is a monthly addition to the CERN Bulletin line-up, showcasing an article by the e-EPS – the European Physical Society newsletter – as part of a new collaboration between the two publications.   EPS members have been invited to take part in a Public Consultation on the Future of Gender and Innovation in Europe. The consultation, which is intended to complement the EC Green Paper ‘From Challenges to Opportunities: Towards a Common Strategic Framework for EU Research and Innovation Funding’, will be published and discussed during the first European Gender Summit in Brussels on 8-9 November this year. It is hoped that the consultation – which is being coordinated by genSET and the organisers of the European Gender Summit – will create a better understanding of how Europe might benefit from a more effective mainstreaming of the gender dimension in research, innovation and scientific systems. Responses from the co...

  16. The clinical practice of interventional radiology: a European perspective.

    LENUS (Irish Health Repository)

    Keeling, Aoife N

    2009-05-01

    The purpose of this study was to determine the current clinical environment in which interventional radiology (IR) is practiced throughout Europe. A survey, comprising 12 questions on IR clinical practice, was sent to 1800 CIRSE members. Members were asked to return one survey per department. Two hundred seventy-four departments returned completed questionnaires, 22% from the United Kingdom (n = 60), 11% from Germany (n = 30), 8% from Austria (n = 23), and the remainder spread over Europe. Experts, with more than 10 years of IR experience, comprised 74% of the survey group. Almost one-third of the radiologists dedicated more than 80% of their clinical sessions to IR alone (27%; n = 75), with two-thirds practicing in a university teaching hospital setting (66%; n = 179). Few institutions have dedicated IR inpatient hospital beds (17%; n = 46), however, to compensate, day case beds are available (31%), IR admitting rights are in place (64% overall, 86% for in-patients, and 89% for day cases), and elective IR admissions can be made through other clinicians (87%). IR outpatient clinics are run at 26% of departments, with an average of two sessions per week. Dedicated nurses staff the majority of IR suites (82%), but clinical junior doctors are lacking (46%). Hospital management\\'s refusing access to beds was the most commonly cited reason for not developing a clinical IR service (41%). In conclusion, there is marked variation across European centers in the current practice of IR. Half do not have dedicated junior doctors and only a small minority have inpatient hospital beds. If IR is to be maintained as a dedicated clinical specialty, these issues need to be addressed urgently.

  17. Research and clinical practice relationship

    Directory of Open Access Journals (Sweden)

    Ashammakhi N

    2008-01-01

    Full Text Available To The Editor: I highly value and greet the authors for their editorial. Many important issues related to medical education and its future in Libya have been discussed in this paper [1]. One important point that has been addressed and I feel deserves attention is the “abnormal” relationship between clinical practice and research in Libya. From discussions with colleagues, this problem somehow has evolved from a misconception about educational and training systems that may have occurred in the past. It may also be related to the lack of attention to research that has long existed in Libya [2,3]. The other aspect, shared with many other developing countries, is the misconception of research as unimportant or a luxury aspect of medicine. When it comes to understanding how a system (including healthcare can be updated and developed, the answer is vague! One important reason is a lack of understanding of the impact that research has on developing methods. In developed countries, research is the main academic distinction that leads to appointments for coveted positions in the system and is an important factor for academic promotion. In Libya, there remain arguments about who will be awarded Chair of university clinical departments. Such a post should no doubt be given to those with established academic achievements. When highly qualified persons are at the top of the pyramid this leads to further progress and enhanced research and advancement. The authors have discussed the point of having proper search committees for leadership and faculty positions. I believe that it will help eliminate the current stagnation and help to create innovative solutions. This should lead to improved medical education, health services, and ultimately impact the quality of life of all Libyan citizens.

  18. European military mental health research: benefits of collaboration.

    Science.gov (United States)

    Himmerich, Hubertus; Willmund, G D; Wesemann, U; Jones, N; Fear, N T

    2017-06-01

    Despite joint participation in international military operations, few collaborative military mental health research projects have been undertaken by European countries. From a common perspective of military mental health researchers from Germany and the UK, the lack of shared research might be related not only to the use of different languages but also the different ways in which the two militaries provide mental health and medical support to operations and differences in military institutions. One area that is suitable for military health research collaboration within UK and German forces is mental health and well-being among military personnel. This could include the study of resilience factors, the prevention of mental disorder, mental health awareness, stigma reduction and the treatment of mental disorder. Military mental health research topics, interests and the studies that have been conducted to date in the UK and Germany have considerable overlap and commonality of purpose. To undertake the investigation of the long-term consequences of operational deployment, the specific burdens placed on military families and to further the understanding of the role of factors such as biomarkers for use in military mental health research, it seems advisable to forge international research alliances across European nations, which would allow for researchers to draw transcultural and generalisable conclusions from their work. Such an enterprise is probably worthwhile given the shared research interests of Germany and the UK and the common perspectives on military mental health in particular. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  19. Professional impact of clinical research

    Energy Technology Data Exchange (ETDEWEB)

    Nelhans, G.

    2016-07-01

    In this study, professional impact is defined as the academic literature that is cited in the literature that is used by professions in order to pursue skilled activities that are specific to their expertise. Specifically, we are focusing on the clinical guidelines that are used in the many health and medical professions that are issued by government bodies at national and international levels to ensure a certain quality level and to make results comparable at the national level. To date, more than 50.000 references have been identified in about 500 Swedish clinical guidelines issued by the above mentioned governmental bodies in Sweden. Of these, 73 % of the references have been matched to a PubMed id. The goal of this project is to develop a conceptual and theoretical contribution to the development of indicators for measuring the impact of research outside of the specifically academic literature. (Author)

  20. Innovations in Doctoral Training and Research on Tinnitus: The European School on Interdisciplinary Tinnitus Research (ESIT Perspective

    Directory of Open Access Journals (Sweden)

    Winfried Schlee

    2018-01-01

    Full Text Available Tinnitus is a common medical condition which interfaces many different disciplines, yet it is not a priority for any individual discipline. A change in its scientific understanding and clinical management requires a shift toward multidisciplinary cooperation, not only in research but also in training. The European School for Interdisciplinary Tinnitus research (ESIT brings together a unique multidisciplinary consortium of clinical practitioners, academic researchers, commercial partners, patient organizations, and public health experts to conduct innovative research and train the next generation of tinnitus researchers. ESIT supports fundamental science and clinical research projects in order to: (1 advancing new treatment solutions for tinnitus, (2 improving existing treatment paradigms, (3 developing innovative research methods, (4 performing genetic studies on, (5 collecting epidemiological data to create new knowledge about prevalence and risk factors, (6 establishing a pan-European data resource. All research projects involve inter-sectoral partnerships through practical training, quite unlike anything that can be offered by any single university alone. Likewise, the postgraduate training curriculum fosters a deep knowledge about tinnitus whilst nurturing transferable competencies in personal qualities and approaches needed to be an effective researcher, knowledge of the standards, requirements and professionalism to do research, and skills to work with others and to ensure the wider impact of research. ESIT is the seed for future generations of creative, entrepreneurial, and innovative researchers, trained to master the upcoming challenges in the tinnitus field, to implement sustained changes in prevention and clinical management of tinnitus, and to shape doctoral education in tinnitus for the future.

  1. The European Repository Landscape 2008 Inventory of Digital Repositories for Research Output

    CERN Document Server

    Van der Graaf, Maurits

    2009-01-01

    It is widely acknowledged that a common knowledge base for European research is necessary. Research repositories are an important innovation to the scientific information infrastructure. In 2006, digital repositories in the 27 countries of the European we

  2. Nanotechnology in medicine: European research and its implications.

    Science.gov (United States)

    Hofmann-Amtenbrink, Margarethe; Hofmann, Heinrich; Hool, Alessandra; Roubert, François

    2014-01-01

    In this study, we explore and discuss nanoparticles and nanoscale materials and their use in medicine (nanomedicine) and pharmaceutics (nanopharmaceutics). The study is aimed at shedding light on this highly multidisciplinary research field and at examining the influence of research funding, industrial applications, and legal and regulatory frameworks on the research in this field, a clear understanding of which is essential to efficiently support the translation of research findings into industrial and clinical applications and to enable access to a larger society.

  3. Offering prenatal diagnostic tests: European guidelines for clinical practice [corrected].

    Science.gov (United States)

    Skirton, Heather; Goldsmith, Lesley; Jackson, Leigh; Lewis, Celine; Chitty, Lyn

    2014-05-01

    For over four decades, it has been possible to offer prenatal diagnostic testing for fetal abnormalities. Prenatal testing is now available for a wide range of monogenic disorders as well as chromosomal abnormalities and should be provided within the ethical framework of informed consent and autonomous choice. However, there are no published guidelines for health professionals from varied disciplines who offer prenatal diagnosis (PND) in a range of possible settings including departments of maternity, obstetrics and clinical genetics. We used an Expert Group technique to develop a set of guidelines for provision of prenatal diagnostic services. Thirteen European health professionals, all experts in PND, participated in a workshop to develop the guidelines, which were then subjected to a wide consultation process. The objective of PND was defined as providing prenatal diagnostic testing services (for genetic conditions) that enable families to make informed choices consistent with their individual needs and values and which support them in dealing with the outcome of such testing. General principles, logistical considerations, clinical care and counselling topics are all described and are equally applicable to invasive and non-invasive testing. These guidelines provide a framework for ethical clinical care; however, they are flexible enough to enable practitioners to adapt them to their particular setting. Ideally, an individualised approach to each family is required to ensure autonomous choice and informed consent regarding prenatal diagnostic testing within the local ethical and legal framework.

  4. Completed | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Prior to the current Clinical Proteomic Tumor Analysis Consortium (CPTAC), previously funded initiatives associated with clinical proteomics research included: Clinical Proteomic Tumor Analysis Consortium (CPTAC 2.0) Clinical Proteomic Technologies for Cancer Initiative (CPTC) Mouse Proteomic Technologies Initiative

  5. Frequently Asked Questions about Clinical Research

    Science.gov (United States)

    ... Tests Statute and Legislation Database Newsroom Calendar of Events Current News Releases Image Gallery GenomeTV Media Contacts Media ... and Genomic Science and Research Genetic and Genomic Science and Research See ... NHGRI Clinical Studies Clinical Research Program Overview On ...

  6. Gender equality observations and actions by the European Research Council

    Science.gov (United States)

    Rydin, Claudia Alves de Jesus; Farina Busto, Luis; Penny, Martin

    2016-04-01

    Women have historically been underrepresented in science. Much positive progress in attracting women to research careers has been achieved in recent years; however, the most influential and high profile positions in most countries are still predominantly occupied by men. The European Research Council (ERC), Europe's premiere funding agency for frontier research, views gender equality as an important challenge. The ERC monitors closely gender figures on every call and has taken actions to tackle gender imbalances and potential unconscious biases. The ERC talk is focused on efforts made to understand and ensure equal treatment of all candidates, with particular focus on gender balance and with specific attention to geosciences. Data and statistics collected from ERC's internationally recognised funding schemes are presented.

  7. Clinical and Technical Phosphoproteomic Research

    Directory of Open Access Journals (Sweden)

    Ferreira Antonio

    2011-06-01

    Full Text Available Abstract An encouraging approach for the diagnosis and effective therapy of immunological pathologies, which would include cancer, is the identification of proteins and phosphorylated proteins. Disease proteomics, in particular, is a potentially useful method for this purpose. A key role is played by protein phosphorylation in the regulation of normal immunology disorders and targets for several new cancer drugs and drug candidates are cancer cells and protein kinases. Protein phosphorylation is a highly dynamic process. The functioning of new drugs is of major importance as is the selection of those patients who would respond best to a specific treatment regime. In all major aspects of cellular life signalling networks are key elements which play a major role in inter- and intracellular communications. They are involved in diverse processes such as cell-cycle progression, cellular metabolism, cell-cell communication and appropriate response to the cellular environment. A whole range of networks that are involved in the regulation of cell development, differentiation, proliferation, apoptosis, and immunologic responses is contained in the latter. It is so necessary to understand and monitor kinase signalling pathways in order to understand many immunology pathologies. Enrichment of phosphorylated proteins or peptides from tissue or bodily fluid samples is required. The application of technologies such as immunoproteomic techniques, phosphoenrichments and mass spectrometry (MS is crucial for the identification and quantification of protein phosphorylation sites in order to advance in clinical research. Pharmacodynamic readouts of disease states and cellular drug responses in tumour samples will be provided as the field develops. We aim to detail the current and most useful techniques with research examples to isolate and carry out clinical phosphoproteomic studies which may be helpful for immunology and cancer research. Different phosphopeptide

  8. Outcome and clinical management of 275 patients with advanced ovarian cancer International Federation of Obstetrics and Gynecology II to IV inside the European Ovarian Cancer Translational Research Consortium-OVCAD.

    Science.gov (United States)

    Chekerov, Radoslav; Braicu, Ioana; Castillo-Tong, Dan Cacsire; Richter, Rolf; Cadron, Isabelle; Mahner, Sven; Woelber, Linn; Marth, Christian; Van Gorp, Toon; Speiser, Paul; Zeillinger, Robert; Vergote, Ignace; Sehouli, Jalid

    2013-02-01

    The Sixth Framework Program European Union project OVCAD, "Ovarian Cancer-Diagnosis of a Silent Killer," aimed to investigate new predictors for early detection of minimal residual disease in epithelial ovarian cancer (EOC). Here we present the main pathologic, surgical, and chemotherapy characteristics of the OVCAD patient cohort. Between February 2005 and December 2008, 5 European gynecologic cancer centers (WP2 group) enrolled prospective 275 consecutive patients with EOC into this translational study. Inclusion criteria were as follows: advanced International Federation of Obstetrics and Gynecology II to IV stage, cytoreductive surgery, platinum-based chemotherapy, and collected tumor samples. WP2 coordinated the implementation, screening, and recruiting of the patients and tumor samples into a Web-based data bank according established standard operating procedures. Median age at the time of diagnosis was 58 years. Most patients presented advanced high-grade EOC: International Federation of Obstetrics and Gynecology III/IV (94.5%), grade 2/3 (96%), serous histology (86.2%), ascites (76%), peritoneal carcinomatosis (67.6%), and lymph node involvement (52%). The most common surgical procedures were omentectomy (92.4%), bilateral salpingo-oophorectomy (90.9%), hysterectomy (77.3%), pelvic (69.5%) and paraaortic (66.9%) lymphadenectomy, and large (37.7%) or small bowel resection (13.4%). Patients were treated commonly with platinum-based therapy (98.2%). The macroscopic cytoreduction rate was 68.4%. After a median follow-up of 37 months, 70 patients (25.5%) developed a platinum-resistant recurrence. Biological materials such as tumor and paraffin tissue, ascites, and blood samples were collected consecutively. The implementation of the OVCAD cohort demonstrated the feasibility and advantages of an open, prospective, and multicenter recruitment inside a translational research study. Essential was the predefinition of all inclusion criteria, standard operating

  9. Clinical Epidemiology Unit - overview of research areas

    Science.gov (United States)

    Clinical Epidemiology Unit (CEU) conducts etiologic research with potential clinical and public health applications, and leads studies evaluating population-based early detection and cancer prevention strategies

  10. Association of Systemic Lupus Erythematosus Clinical Features with European Population Genetic Substructure

    Science.gov (United States)

    Calaza, Manuel; Witte, Torsten; Papasteriades, Chryssa; Marchini, Maurizio; Migliaresi, Sergio; Kovacs, Attila; Ordi-Ros, Josep; Bijl, Marc; Santos, Maria Jose; Ruzickova, Sarka; Pullmann, Rudolf; Carreira, Patricia; Skopouli, Fotini N.; D'Alfonso, Sandra; Sebastiani, Gian Domenico; Suarez, Ana; Blanco, Francisco J.; Gomez-Reino, Juan J.; Gonzalez, Antonio

    2011-01-01

    Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population genetic substructure. Data from 1413 patients of European ancestry recruited in nine countries was tested for association with genotypes of top ancestry informative markers. This analysis was done with logistic regression between phenotypes and genotypes or principal components extracted from them. We used a genetic additive model and adjusted for gender and disease duration. Three clinical features showed association with ancestry informative markers: autoantibody production defined as immunologic disorder (P = 6.8×10−4), oral ulcers (P = 6.9×10−4) and photosensitivity (P = 0.002). Immunologic disorder was associated with genotypes more common in Southern European ancestries, whereas the opposite trend was observed for photosensitivity. Oral ulcers were specifically more common in patients of Spanish and Portuguese self-reported ancestry. These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested. PMID:22194982

  11. Association of systemic lupus erythematosus clinical features with European population genetic substructure.

    Directory of Open Access Journals (Sweden)

    Elisa Alonso-Perez

    Full Text Available Systemic Lupus Erythematosus (SLE is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population genetic substructure. Data from 1413 patients of European ancestry recruited in nine countries was tested for association with genotypes of top ancestry informative markers. This analysis was done with logistic regression between phenotypes and genotypes or principal components extracted from them. We used a genetic additive model and adjusted for gender and disease duration. Three clinical features showed association with ancestry informative markers: autoantibody production defined as immunologic disorder (P = 6.8×10(-4, oral ulcers (P = 6.9×10(-4 and photosensitivity (P = 0.002. Immunologic disorder was associated with genotypes more common in Southern European ancestries, whereas the opposite trend was observed for photosensitivity. Oral ulcers were specifically more common in patients of Spanish and Portuguese self-reported ancestry. These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested.

  12. Association of systemic lupus erythematosus clinical features with European population genetic substructure.

    Science.gov (United States)

    Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Witte, Torsten; Papasteriades, Chryssa; Marchini, Maurizio; Migliaresi, Sergio; Kovacs, Attila; Ordi-Ros, Josep; Bijl, Marc; Santos, Maria Jose; Ruzickova, Sarka; Pullmann, Rudolf; Carreira, Patricia; Skopouli, Fotini N; D'Alfonso, Sandra; Sebastiani, Gian Domenico; Suarez, Ana; Blanco, Francisco J; Gomez-Reino, Juan J; Gonzalez, Antonio

    2011-01-01

    Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population genetic substructure. Data from 1413 patients of European ancestry recruited in nine countries was tested for association with genotypes of top ancestry informative markers. This analysis was done with logistic regression between phenotypes and genotypes or principal components extracted from them. We used a genetic additive model and adjusted for gender and disease duration. Three clinical features showed association with ancestry informative markers: autoantibody production defined as immunologic disorder (P = 6.8×10(-4)), oral ulcers (P = 6.9×10(-4)) and photosensitivity (P = 0.002). Immunologic disorder was associated with genotypes more common in Southern European ancestries, whereas the opposite trend was observed for photosensitivity. Oral ulcers were specifically more common in patients of Spanish and Portuguese self-reported ancestry. These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested.

  13. CERIF: The Common European Research Information Format Model

    Directory of Open Access Journals (Sweden)

    Brigitte Jörg

    2010-09-01

    Full Text Available With increased computing power more data than ever are being and will be produced, stored and (re- used. Data are collected in databases, computed and annotated, or transformed by specific tools. The knowledge from data is documented in research publications, reports, presentations, or other types of files. The management of data and knowledge is difficult, and even more complicated is their re-use, exchange, or integration. To allow for quality analysis or integration across data sets and to ensure access to scientific knowledge, additional information - Research Information - has to be assigned to data and knowledge entities. We present the metadata model CERIF to add information to entities such as Publication, Project, Organisation, Person, Product, Patent, Service, Equipment, and Facility and to manage the semantically enhanced relationships between these entities in a formalized way. CERIF has been released as an EC Recommendation to European Member States in 2000. Here, we refer to the latest version CERIF 2008-1.0.

  14. An electronic delphi study to establish pediatric intensive care nursing research priorities in twenty European countries*.

    Science.gov (United States)

    Tume, Lyvonne N; van den Hoogen, Agnes; Wielenga, Joke M; Latour, Jos M

    2014-06-01

    To identify and to establish research priorities for pediatric intensive care nursing science across Europe. A modified three-round electronic Delphi technique was applied. Questionnaires were translated into seven different languages. European PICUs. The participants included pediatric intensive care clinical nurses, managers, educators, and researchers. In round 1, the qualitative responses were analyzed by content analysis and a list of research statements and domains was generated. In rounds 2 and 3, the statements were ranked on a scale of one to six (not important to most important). Mean scores and SDs were calculated for rounds 2 and 3. None. Round 1 started with 90 participants, with round 3 completed by 64 (71%). The seven highest ranking statements (≥ 5.0 mean score) were related to end-of-life care, decision making around forgoing and sustaining treatment, prevention of pain, education and competencies for pediatric intensive care nurses, reducing healthcare-associated infections, identifying appropriate nurse staffing levels, and implementing evidence into nursing practice. Nine research domains were prioritized, and these were as follows: 1) clinical nursing care practices, 2) pain and sedation, 3) quality and safety, 4) respiratory and mechanical ventilation, 5) child- and family-centered care, 6) ethics, 7) professional issues in nursing, 8) hemodynamcis and resuscitation, and 9) trauma and neurocritical care. The results of this study inform the European Society of Pediatric and Neonatal Intensive Care's nursing research agenda in the future. The results allow nurse researchers within Europe to encourage collaborative initiatives for nursing research.

  15. Acquisition of European research funds and its effect on international scientific collaboration

    NARCIS (Netherlands)

    Hoekman, J.|info:eu-repo/dai/nl/305349929; Scherngell, T.; Frenken, K.|info:eu-repo/dai/nl/207145253; Tijssen, R.

    2013-01-01

    The Framework Programmes (FPs) funded by the European Commission support transnational research collaborations in order to make the European Research Area more competitive. Some have raised concerns that the FPs compromise the cohesion policies of the European Commission aimed at reducing income

  16. Acquisition of European research funds and its effect on international scientific collaboration

    NARCIS (Netherlands)

    Hoekman, Jarno; Scherngell, Thomas; Frenken, Koen; Tijssen, Robert

    The Framework Programmes (FPs) funded by the European Commission support transnational research collaborations in order to make the European Research Area more competitive. Some have raised concerns that the FPs compromise the cohesion policies of the European Commission aimed at reducing income

  17. European neonatal intensive care nursing research priorities: an e-Delphi study.

    Science.gov (United States)

    Wielenga, Joke M; Tume, Lyvonne N; Latour, Jos M; van den Hoogen, Agnes

    2015-01-01

    This study aimed to identify and prioritise neonatal intensive care nursing research topics across Europe using an e-Delphi technique. An e-Delphi technique with three questionnaire rounds was performed. Qualitative responses of round one were analysed by content analysis and research statements were generated to be ranged on importance on a scale of 1-6 (not important to most important). Neonatal intensive care units (NICUs) in 17 European countries. NICU clinical nurses, managers, educators and researchers (n=75). None. A list of 43 research statements in eight domains. The six highest ranking statements (≥5.0 mean score) were related to prevention and reduction of pain (mean 5.49; SD 1.07), medication errors (mean 5.20; SD 1.13), end-of-life care (mean 5.05; SD 1.18), needs of parents and family (mean 5.04; SD 1.23), implementing evidence into nursing practice (mean 5.02; SD 1.03), and pain assessment (mean 5.02; SD 1.11). The research domains were prioritised and ranked: (1) pain and stress; (2) family centred care; (3) clinical nursing care practices; (4) quality and safety; (5) ethics; (6) respiratory and ventilation; (7) infection and inflammation; and (8) professional issues in neonatal intensive care nursing. The results of this study might support developing a nursing research strategy for the nursing section of the European Society of Paediatric and Neonatal Intensive Care. In addition, this may promote more European researcher collaboratives for neonatal nursing research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  18. Euratom research and training in nuclear reactor safety: Towards European research and the higher education area

    Energy Technology Data Exchange (ETDEWEB)

    Goethem, G. van [Nuclear Fission and Radiation Protection European Commission, Building MO75-5-34, B-1049 Brussels (Belgium)]. E-mail: georges.van-goethem@cec.eu.int

    2004-07-01

    In this invited lecture, research and training in nuclear fission are looked at from a European perspective with emphasis on the three success factors of any European policy, namely: common needs, vision and instruments, that ought to be strongly shared amongst the stakeholders across the Member States concerned. As a result, the following questions are addressed: What is driving the current EU trend towards more research, more education and more training, in general? Regarding nuclear fission, in particular, who are the end-users of Euratom 'research and training' and what are their expectations from EU programmes? Do all stakeholders share the same vision about European research and training in nuclear fission? What are the instruments proposed by the European Commission (EC) to conduct joint research programmes of common interest for the nuclear fission community? In conclusion, amongst the stakeholders in Europe, there seems to be a wide consensus about common needs and instruments, but not about a common vision regarding nuclear. (author)

  19. The importance of national laws in the implementation of European legislation of biomedical research.

    Science.gov (United States)

    Sprumont, Dominique; Gytis, Andrulionis

    2005-09-01

    The industrialization and internationalization of biomedical research is not without consequences on the regulation of research or, at least, on the interpretation of that regulation. As more research is done at the international level, the pharmaceutical industry and the research community are calling for a harmonized regulation to limit the administrative burden of controlling clinical trials and to fasten the R&D process. The purpose of this paper is to analyse briefly the role of the national laws in that process. Part I will outline the structure and the nature of the international regulation of research in a European perspective. Using the examples of research ethics committees (RECs), informed consent and the question of liability and liability insurance, Part II will analyze the importance of the national laws in the implementation of this international regulation.

  20. A research agenda for the European Association for Endoscopic Surgeons (EAES)

    DEFF Research Database (Denmark)

    Francis, Nader; Kazaryan, Airazat M; Pietrabissa, Andrea

    2017-01-01

    INTRODUCTION: The European Association of Endoscopic Surgeons (EAES) conducted this study aiming to identify the top research questions which are relevant to surgeons in Minimal Access Surgery (MAS). This is in order to promote and link research questions to the current clinical practice in MAS...... in Europe. METHODS: Using a systematic methodology, (modified Delphi), the EAES members and leadership teams were surveyed to obtain consensus on the top research priorities in MAS. The responses were categorized and redistributed to the membership to rate the level of importance of each research question...... identified 39 research priorities with rating ranged from 4.22 to 3.67. The top five highest ranking research priorities in the EAES were centered on improving training in MAS, laparoscopic surgery for benign upper gastrointestinal conditions, integration of novel technology in OR, translational and basic...

  1. European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership

    OpenAIRE

    Ofori-Adjei David; Zijenah Lynn; Ndounga Mathieu; Ambene Herman PA; Kitua Andrew Y; Jaoko Walter G; Corrah Tumani; Ndumbe Peter M; Manyando Christine; Matee Mecky I; Agwale Simon; Shongwe Steven; Nyirenda Thomas; Makanga Michael

    2009-01-01

    Abstract Background European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, and Developing Countries, formed to fund acceleration of new clinical trial interventions to fight the human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), malaria and tuberculosis (TB) in the sub-Saharan African region. EDCTP seeks to b...

  2. Challenges in communicating research and research careers: lesson learned from the European Researchers' Nights at INGV

    Science.gov (United States)

    D'Addezio, Giuliana; Rubbia, Giuliana; Musacchio, Gemma; Lanza, Tiziana

    2014-05-01

    Since 2009 the Istituto Nazionale di Geofisica e Vulcanologia (INGV) participates to the European Researchers' Night, promoted by the European Commission, in the framework of Associazione Frascati Scienza (http://www.frascatiscienza.it/), with a program rich of events aimed at intriguingnand stimulating audiences of all ages about Earth Sciences, i.e., to make the general public aware on activities and roles of INGV researchers. For the September 27th Night, INGV contributed with a program in the INGV headquarters inspired by the INGV ScienzAperta Open Day held in April: guided tours, as well seminars held by researchers, exhibitions, educational games. We proposed two parallel programs: one devoted to earthquakes, including the visit to the INGV seismic surveillance room, seminars about Italian territory seismic hazard and exhibitions on Earthquakes and Volcanoes; the alternative program included the guided tour of the INGV laboratories (Aero-photogrammetry, Paleo-magnetism beside exhibition on geomagnetism, High Pressures and High Temperatures, Geochemistry, Restoration of historical instruments). In Frascati, we organized educational games, hands-on laboratories and a science theatre performance: "When the sky flashed red", as well as exhibitions at Museo Geofisico Rocca di Papa. A paper-based appreciation survey, compiled by visitors at INGV headquarter and by the scientific theatre's audiences, supplied our team with feedback, revealing some precious hints about users themselves, appreciation and margins of improvement, both in organization and in content. People of all ages and professions came. For example, a father asked specific paths for children, with even more appropriate language. A boy (aged 11) found the visit to the labs "interesting but a bit boring". It was suggested to prepare specific hand-outs for each visit, and certificates of participation for students. A girl, 9 years old, wrote that such event makes her closer to science world. The

  3. Stuttering: Clinical and research update.

    Science.gov (United States)

    Perez, Hector R; Stoeckle, James H

    2016-06-01

    To provide an update on the epidemiology, genetics, pathophysiology, diagnosis, and treatment of developmental stuttering. The MEDLINE and Cochrane databases were searched for past and recent studies on the epidemiology, genetics, pathophysiology, diagnosis, and treatment of developmental stuttering. Most recommendations are based on small studies, limited-quality evidence, or consensus. Stuttering is a speech disorder, common in persons of all ages, that affects normal fluency and time patterning of speech. Stuttering has been associated with differences in brain anatomy, functioning, and dopamine regulation thought to be due to genetic causes. Attention to making a correct diagnosis or referral in children is important because there is growing consensus that early intervention with speech therapy for children who stutter is critical. For adults, stuttering can be associated with substantial psychosocial morbidity including social anxiety and low quality of life. Pharmacologic treatment has received attention in recent years, but clinical evidence is limited. The mainstay of treatment for children and adults remains speech therapy. A growing body of research has attempted to uncover the pathophysiology of stuttering. Referral for speech therapy remains the best option for children and adults. Copyright© the College of Family Physicians of Canada.

  4. European and Developing Countries Clinical Trials Partnership (EDCTP: the path towards a true partnership

    Directory of Open Access Journals (Sweden)

    Ofori-Adjei David

    2009-07-01

    Full Text Available Abstract Background European and Developing Countries Clinical Trials Partnership (EDCTP was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU member states, Norway, Switzerland, and Developing Countries, formed to fund acceleration of new clinical trial interventions to fight the human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS, malaria and tuberculosis (TB in the sub-Saharan African region. EDCTP seeks to be synergistic with other funding bodies supporting research on these diseases. Methods EDCTP promotes collaborative research supported by multiple funding agencies and harnesses networking expertise across different African and European countries. EDCTP is different from other similar initiatives. The organisation of EDCTP blends important aspects of partnership that includes ownership, sustainability and responds to demand-driven research. The Developing Countries Coordinating Committee (DCCC; a team of independent scientists and representatives of regional health bodies from sub-Saharan Africa provides advice to the partnership. Thus EDCTP reflects a true partnership and the active involvement and contribution of these African scientists ensures joint ownership of the EDCTP programme with European counterparts. Results The following have been the major achievements of the EDCTP initiative since its formation in 2003; i increase in the number of participating African countries from two to 26 in 2008 ii the cumulative amount of funds spent on EDCTP projects has reached € 150 m, iii the cumulative number of clinical trials approved has reached 40 and iv there has been a significant increase number and diversity in capacity building activities. Conclusion While we recognise that EDCTP faced enormous challenges in its first few years of existence, the strong involvement of African scientists and its new initiatives such as unconditional funding to regional

  5. European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership.

    Science.gov (United States)

    Matee, Mecky I; Manyando, Christine; Ndumbe, Peter M; Corrah, Tumani; Jaoko, Walter G; Kitua, Andrew Y; Ambene, Herman Pa; Ndounga, Mathieu; Zijenah, Lynn; Ofori-Adjei, David; Agwale, Simon; Shongwe, Steven; Nyirenda, Thomas; Makanga, Michael

    2009-07-20

    European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, and Developing Countries, formed to fund acceleration of new clinical trial interventions to fight the human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), malaria and tuberculosis (TB) in the sub-Saharan African region. EDCTP seeks to be synergistic with other funding bodies supporting research on these diseases. EDCTP promotes collaborative research supported by multiple funding agencies and harnesses networking expertise across different African and European countries. EDCTP is different from other similar initiatives. The organisation of EDCTP blends important aspects of partnership that includes ownership, sustainability and responds to demand-driven research. The Developing Countries Coordinating Committee (DCCC); a team of independent scientists and representatives of regional health bodies from sub-Saharan Africa provides advice to the partnership. Thus EDCTP reflects a true partnership and the active involvement and contribution of these African scientists ensures joint ownership of the EDCTP programme with European counterparts. The following have been the major achievements of the EDCTP initiative since its formation in 2003; i) increase in the number of participating African countries from two to 26 in 2008 ii) the cumulative amount of funds spent on EDCTP projects has reached 150 m euros, iii) the cumulative number of clinical trials approved has reached 40 and iv) there has been a significant increase number and diversity in capacity building activities. While we recognise that EDCTP faced enormous challenges in its first few years of existence, the strong involvement of African scientists and its new initiatives such as unconditional funding to regional networks of excellence in sub-Saharan Africa is envisaged to

  6. Clinical characteristics of patients from the worldwide registry on peripartum cardiomyopathy (PPCM): EURObservational Research Programme in conjunction with the Heart Failure Association of the European Society of Cardiology Study Group on PPCM.

    Science.gov (United States)

    Sliwa, Karen; Mebazaa, Alexandre; Hilfiker-Kleiner, Denise; Petrie, Mark C; Maggioni, Aldo P; Laroche, Cecile; Regitz-Zagrosek, Vera; Schaufelberger, Maria; Tavazzi, Luigi; van der Meer, Peter; Roos-Hesselink, Jolien W; Seferovic, Petar; van Spandonck-Zwarts, Karin; Mbakwem, Amam; Böhm, Michael; Mouquet, Frederic; Pieske, Burkert; Hall, Roger; Ponikowski, Piotre; Bauersachs, Johann

    2017-09-01

    The purpose of this study is to describe disease presentation, co-morbidities, diagnosis and initial therapeutic management of patients with peripartum cardiomyopathy (PPCM) living in countries belonging to the European Society of Cardiology (ESC) vs. non-ESC countries. Out of 500 patients with PPCM entered by 31 March 2016, we report on data of the first 411 patients with completed case record forms (from 43 countries) entered into this ongoing registry. There were marked differences in socio-demographic parameters such as Human Development Index, GINI index on inequality, and Health Expenditure in PPCM patients from ESC vs. non-ESC countries (P heart failure after 1 month (92.3% vs. 81.3%, P heart failure were common within 1 month post-diagnosis and required intensive, multidisciplinary management. © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.

  7. Community participation in clinical health research - a new research ...

    African Journals Online (AJOL)

    The purpose of this review article is to explore and describe the notion of community participation in clinical health research, the complexities and challenges thereof and the paradigm shift of closing the gap between theory and practice, researcher and community in clinical health research. A new research paradigm is ...

  8. AURORA BOREALIS: a polar-dedicated European Research Platform

    Science.gov (United States)

    Wolff-Boenisch, Bonnie; Egerton, Paul; Thiede, Joern; Roberto, Azzolini; Lembke-Jene, Lester

    2010-05-01

    Polar research and in particular the properties of northern and southern high latitude oceans are currently a subject of intense scientific debate and investigations, because they are subject to rapid and dramatic climatic variations. Polar regions react more rapidly and intensively to global change than other regions of the earth. A shrinking of the Arctic sea-ice cover, potentially leading to an opening of sea passages to the north of North America and Eurasia, on the long to a "blue" Arctic Ocean would additionally have a strong impact on transport, commerce and tourism bearing potential risk for humans and complex ecosystems in the future. In spite of their critical role processes and feedbacks, especially in winter but not exclusively, are virtually unknown: The Arctic Ocean for example, it is the only basin of the world's oceans that has essentially not been sampled by the drill ships of the Deep-Sea Drilling Project (DSDP) or the Ocean Drilling Program (ODP) and its long-term environmental history and tectonic structure is therefore poorly known. Exceptions are the ODP Leg 151 and the more recent very successful ACEX-expedition of the Integrated Ocean Drilling Program (IODP) in 2004. To help to address the most pressing questions regarding climate change and related processes, a Pan-European initiative in the field of Earth system science has been put in place: AURORA BOREALIS is the largest environmental research infrastructure on the ESFRI roadmap of the European Community. AURORA BOREALIS is a very powerful research icebreaker, which will enable year-round operations in the Arctic and the Antarctic as well as in the adjacent ocean basins. Equipped with its drilling rig, the vessel is also capable to explore the presently completely unknown Arctic deep-sea floor. Last but not least, the ship is a floating observatory and mobile monitoring platform that permits to measure on a long-term basis comprehensive time series in all research fields relevant to

  9. Research projects in family medicine funded by the European Union.

    Science.gov (United States)

    Pavličević, Ivančica; Barać, Lana

    2014-01-01

    This study aimed at synthesizing funding opportunities in the field of family medicine by determining the number of family medicine projects, as well as number of project leaderships and/ or participations by each country. This was done in order to encourage inclusion of physicians in countries with underdeveloped research networks in successful research networks or to encourage them to form new ones. We searched the Community Research and Development Information Service project database in February 2013. Study covered the period from years 1992 - 2012, selecting the projects within the field of general/family medicine. The search was conducted in February 2013. First search conducted in the CORDIS database came up with a total of 466 projects. After excluding 241 projects with insufficient data, we analysed 225 remaining projects; out of those, 22 (9.8%) were in the field of family medicine and 203 (90.2%) were from other fields of medicine. Sorted by the number of projects per country, Dutch institutions had the highest involvement in family medicine projects and were partners or coordinators in 18 out of 22 selected projects (81.8%), followed by British institutions with 15 (68.8%), and Spanish with 10 projects (45.5%). Croatia was a partner in a single FP7 Health project. Research projects in family medicine funded by the European Union show significant differences between countries. Constant and high-quality international cooperation in family medicine is the prerequisite for improvement and development of scientific research and the profession. Copyright © 2014 by Academy of Sciences and Arts of Bosnia and Herzegovina.

  10. Research projects in family medicine funded by the European Union

    Directory of Open Access Journals (Sweden)

    Ivančica Pavličević

    2014-05-01

    Full Text Available Objective. This study aimed at synthesizing funding opportunities in the field of family medicine by determining the number of family medicine projects, as well as number of project leaderships and/ or participations by each country. This was done in order to encourage inclusion of physicians in countries with underdeveloped research networks in successful research networks or to encourage them to form new ones. Methods. We searched the Community Research and Development Information Service project database in February 2013. Study covered the period from years 1992 – 2012, selecting the projects within the field of general/family medicine. The search was conducted in February 2013. Results. First search conducted in the CORDIS database came up with a total of 466 projects. After excluding 241 projects with insufficient data, we analysed 225 remaining projects; out of those, 22 (9.8% were in the field of family medicine and 203 (90.2% were from other fields of medicine. Sorted by the number of projects per country, Dutch institutions had the highest involvement in family medicine projects and were partners or coordinators in 18 out of 22 selected projects (81.8%, followed by British institutions with 15 (68.8%, and Spanish with 10 projects (45.5%. Croatia was a partner in a single FP7 Health project. Conclusion. Research projects in family medicine funded by the European Union show significant differences between countries. Constant and high-quality international cooperation in family medicine is the prerequisite for improvement and development of scientific research and the profession.

  11. Basic Tenets of Clinical Research

    OpenAIRE

    Nagalakshmi Jawaharlal; K Umasankar

    2012-01-01

    Objective : Scientific research is the cornerstone of development and conducting research in a systematic and structured manner which is mandatory for universal acceptance. Aims : The objective of the article is to give a ring-side view of research in dentistry for the clinicians interested in research and publication. Discussion : The research methodology, results, summarization and publication of the results are the basic tenets which this article elaborates upon. The ethics of conduc...

  12. "Innovation and Intellectual Property Policies in European Research Infrastructure Consortia - PART I: The Case of the European Spallation Source ERIC"

    DEFF Research Database (Denmark)

    Yu, Helen; Wested, Jakob; Minssen, Timo

    2017-01-01

    of the problems society is facing today. To facilitate the creation and operation of such RIs, the EU adopted legal frameworks for European Research Infrastructure Consortia (ERIC). On August 31, 2015, the European Spallation Source (ESS) was established as an ERIC. Under the ERIC Regulations and ESS Statutes......, the European Spallation Source ERIC is required to adopt various policy documents relating to the operation and management of the facility. These cover a wide variety of issues such as user access, public procurement, intellectual property rights (IPR), data management, and dissemination. One of the main goals...... international research collaborations? The complex relationship between scientific excellence, innovation, and IPRs must be carefully considered. Taking the European Spallation Source ERIC as an example, this article investigates ERIC Regulations and EU policies and discusses what issues and perspectives ERICs...

  13. LEMUR: Large European Module for Solar Ultraviolet Research

    Science.gov (United States)

    Teriaca, Luca; Vincenzo, Andretta; Auchere, Frederic; Brown, Charles M.; Buchlin, Eric; Cauzzi, Gianna; Culhane, J. Len; Curdt, Werner; Davila, Joseph M.; Del Zanna, Giulio; hide

    2012-01-01

    The solar outer atmosphere is an extremely dynamic environment characterized by the continuous interplay between the plasma and the magnetic field that generates and permeates it. Such interactions play a fundamental role in hugely diverse astrophysical systems, but occur at scales that cannot be studied outside the solar system. Understanding this complex system requires concerted, simultaneous solar observations from the visible to the vacuum ultraviolet (VUV) and soft X-rays, at high spatial resolution (between 0.1'' and 0.3''), at high temporal resolution (on the order of 10 s, i.e., the time scale of chromospheric dynamics), with a wide temperature coverage (0.01 MK to 20 MK, from the chromosphere to the flaring corona), and the capability of measuring magnetic fields through spectropolarimetry at visible and near-infrared wavelengths. Simultaneous spectroscopic measurements sampling the entire temperature range are particularly important. These requirements are fulfilled by the Japanese Solar-C mission (Plan B), composed of a spacecraft in a geosynchronous orbit with a payload providing a significant improvement of imaging and spectropolarimetric capabilities in the UV, visible, and near-infrared with respect to what is available today and foreseen in the near future. The Large European Module for solar Ultraviolet Research (LEMUR), described in this paper, is a large VUV telescope feeding a scientific payload of high-resolution imaging spectrographs and cameras. LEMUR consists of two major components: a VUV solar telescope with a 30 cm diameter mirror and a focal length of 3.6 m, and a focal-plane package composed of VUV spectrometers covering six carefully chosen wavelength ranges between 170 Angstrom and 1270 Angstrom. The LEMUR slit covers 280'' on the Sun with 0.14'' per pixel sampling. In addition, LEMUR is capable of measuring mass flows velocities (line shifts) down to 2 km s - 1 or better. LEMUR has been proposed to ESA as the European contribution

  14. Understanding European education landscape on natural disasters - a textbook research

    Science.gov (United States)

    Komac, B.; Zorn, M.; Ciglič, R.; Steinführer, A.

    2012-04-01

    The importance of natural-disaster education for social preparedness is presented. Increasing damage caused by natural disasters around the globe draws attention to the fact that even developed societies must adapt to natural processes. Natural-disaster education is a component part of any education strategy for a sustainably oriented society. The purpose of this article is to present the role of formal education in natural disasters in Europe. To ensure a uniform overview, the study used secondary-school geography textbooks from the collection at the Georg Eckert Institute for International Textbook Research in Braunschweig, Germany. Altogether, nearly 190 textbooks from 35 European countries were examined. The greatest focus on natural disasters can be found in textbooks published in western Europe (3.8% of pages describing natural disasters), and the smallest in those published in eastern Europe (0.7%). A share of textbook pages exceeding three percent describing natural disasters can also be found in northern Europe (3.6%) and southeast Europe, including Turkey (3.4%). The shares in central and southern Europe exceed two percent (i.e., 2.8% and 2.3%, respectively). The types and specific examples of natural disasters most commonly covered in textbooks as well as the type of natural disasters presented in textbooks according to the number of casualties and the damage caused were analyzed. The results show that the majority of European (secondary-school) education systems are poorly developed in terms of natural-disaster education. If education is perceived as part of natural-disaster management and governance, greater attention should clearly be dedicated to this activity. In addition to formal education, informal education also raises a series of questions connected with the importance of this type of education. Special attention was drawn to the importance of knowledge that locals have about their region because this aspect of education is important in both

  15. Prostate Cancer Clinical Consortium Clinical Research Site:Targeted Therapies

    Science.gov (United States)

    2015-10-01

    targeted therapy on the efficacy of cabazitaxel in men with metastatic castration-resistant prostate cancer R. Van Soest1, A. Nieuweboer2, E. De...AWARD NUMBER: W81XWH-14-2-0159 TITLE: Prostate Cancer Clinical Consortium Clinical Research Site: Targeted Therapies PRINCIPAL INVESTIGATOR...Sep 2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Prostate Cancer Clinical Consortium Clinical Research Site: Targeted Therapies 5b. GRANT NUMBER

  16. Clinical diagnosis of dental caries: a European perspective.

    Science.gov (United States)

    Pitts, N B

    2001-10-01

    The aim of this paper is to provide a broad international perspective on aspects of the RTI/UNC systematic review, to introduce relevant literature not cited, and to make recommendations for clinical practice education and research suggested by the evidence. Clinical caries diagnosis represents the foundation on which the answers to most of the consensus questions will be based. This paper highlights needs for being clear about definitions and nomenclature; understanding the importance of the concepts underlying the D1 and D3 diagnostic thresholds used widely within the RTI/UNC Review; and appreciating that the diagnostic challenge now faced by clinicians is significant and is becoming more complex as the presentation and distribution of the disease changes over time and the range of preventive and operative treatment options expands. A series of recommendations informed by the evidence are made, including a rather contentious issue for many clinicians concerning the lack of evidence supporting the continued use of a sharp explorer as a diagnostic tool for primary caries diagnosis. This practice should be discontinued as it may cause some harm to the patient and yet fails to provide a significant balancing diagnostic benefit. Finally, it is suggested that dentistry should learn from the developing evidence base in medicine on how best to disseminate the findings of reviews and promote appropriate changes in clinical practice.

  17. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI)

    DEFF Research Database (Denmark)

    Maas, Andrew I R; Menon, David K; Steyerberg, Ewout W

    2015-01-01

    BACKGROUND: Current classification of traumatic brain injury (TBI) is suboptimal, and management is based on weak evidence, with little attempt to personalize treatment. A need exists for new precision medicine and stratified management approaches that incorporate emerging technologies. OBJECTIVE......: To improve characterization and classification of TBI and to identify best clinical care, using comparative effectiveness research approaches. METHODS: This multicenter, longitudinal, prospective, observational study in 22 countries across Europe and Israel will collect detailed data from 5400 consenting...... in process and clinical care. Results will be integrated with living systematic reviews in a process of knowledge transfer. The study initiation was from October to December 2014, and the recruitment period was for 18 to 24 months. EXPECTED OUTCOMES: Collaborative European NeuroTrauma Effectiveness Research...

  18. Europlanet - Joining the European Planetary Research Information Service

    Science.gov (United States)

    Capria, M. T.; Chanteur, G.; Schmidt, W.

    2009-04-01

    The "Europlanet Research Infrastructure - Europlanet RI", supported by the European Commission's Framework Program 7, aims at integrating major parts of the distributed European Planetary Research infrastructure with as diverse components as space exploration, ground-based observations, laboratory experiments and numerical model-ling teams. A central part of Europlanet RI is the "Integrated and Distributed Information Service" or Europlanet-IDIS which intends to provide easy Web-based access to information about scientists and teams working in related fields, observatories or laboratories with capabilities possibly beneficial to planetary research, modelling expertise useful for planetary science and observations from space-based, ground-based or laboratory measurements. As far as the type of data and their access methods allow, IDIS will provide Virtual Observatory (VO) like access to a variety of data from distributed sources and tools to compare and integrate this information to further data analysis and re-search. IDIS itself is providing a platform for information and data sharing and for data mining. It is structured as a network of thematic nodes each concentrating on a sub-set of research areas in planetary sciences. But the most important elements of IDIS and the whole Europlanet RI are the single scientists, institutes, laboratories, observatories and mission project teams. Without them the whole effort would remain an empty shell. How can an interested individual or team join this activity and what are the benefits to be expected from the related effort? The poster gives detailed answers to these questions. Here some highlights: 1. Locate from the Europlanet web pages (addresses see below) the thematic node best related to the own field of expertise. This might be more than one. 2. Define which services you want to offer to the community: just the contact address, field of competence, off-line access to data on request or even on-line searchable access

  19. Clinical research: Should patients pay to play?

    Science.gov (United States)

    Emanuel, Ezekiel J; Joffe, Steven; Grady, Christine; Wendler, David; Persad, Govind

    2015-07-29

    Permitting patients to pay for participation in clinical research threatens the principles of social value and fair subject selection as well as robust clinical trial design. Copyright © 2015, American Association for the Advancement of Science.

  20. Mapping ongoing European research activities examining the infectious aetiology of chronic conditions.

    Science.gov (United States)

    Semenza, J C; Svederud, I; Medin, E; Orrskog, S; Tsolova, S

    2013-09-01

    Chronic conditions contribute to the majority of the mortality and morbidity burden in Europe. The extent to which infectious agents are responsible for the chronic disease burden remains elusive. The complex nature of the natural history of chronic conditions calls for an overview of ongoing research activities linking infectious agents with these conditions in order to guide research endeavours, direct research funding, steer prevention efforts, and point health policy towards promising interventions. A selection of websites hosted by institutions either financing or conducting research within the European Union was screened for ongoing research activities examining infectious aetiology of chronic conditions. The searches were conducted until September 2011, applying search strategies and inclusion criteria predefined in a study protocol. In total, 25 research activities met the inclusion criteria. Of those, ten activities were focused to investigate infectious aetiology of cancer, four focused on type 2 diabetes mellitus, and 11 focused on a wide spectrum of other chronic conditions. The identified research projects did not cover areas such as mental and behavioural disorders. Infectious agents analysed included enteroviruses, Epstein-Barr virus, human rhinoviruses, P. gingivalis, human papillomaviruses, cytomegalovirus, Helicobacter spp. and human parvovirus. Only three projects specifically addressed therapeutic interventions. Ultimately, linking infectious agents with chronic conditions may translate into prevention efforts with vaccinations or treatment strategies with antimicrobial agents, and could, thus, eventually reduce the heavy disease burden from chronic conditions. However, little translational research on therapeutic interventions was found in our search and should be fostered, particularly for more established infectious-chronic disease associations. © 2012 The Authors. Clinical Microbiology and Infection © 2012 European Society of Clinical

  1. "Innovation and Intellectual Property Policies in European Research Infrastructure Consortia - PART I: The Case of the European Spallation Source ERIC"

    DEFF Research Database (Denmark)

    Yu, Helen; Wested, Jakob; Minssen, Timo

    2017-01-01

    Research and innovation are key pillars of the EU’s strategy to create sustainable growth and prosperity in Europe. Research infrastructures (RIs) are central instruments to implement this strategy. They bring together a wide diversity of expertise and interests to look for solutions to many...... of the problems society is facing today. To facilitate the creation and operation of such RIs, the EU adopted legal frameworks for European Research Infrastructure Consortia (ERIC). On August 31, 2015, the European Spallation Source (ESS) was established as an ERIC. Under the ERIC Regulations and ESS Statutes......, the European Spallation Source ERIC is required to adopt various policy documents relating to the operation and management of the facility. These cover a wide variety of issues such as user access, public procurement, intellectual property rights (IPR), data management, and dissemination. One of the main goals...

  2. Research leadership: should clinical directors be distinguished researchers?

    Science.gov (United States)

    Allison, Stephen; Goodall, Amanda H; Bastiampillai, Tarun

    2016-06-01

    Clinical directors established research-led healthcare by combining research, teaching and clinical excellence within the teaching hospitals. This research culture created high clinical standards, which benefited patients, the workforce and healthcare organisations. The current paper explores this research leadership role for clinical directors. It reviews studies arising from the theory of expert leadership, which focuses on the relationship between a leader's core knowledge and organisational performance. More specifically, we examine the expert leader's research track record, the associations with their organisation's performance, and the influence of research activity on clinical excellence. Distinguished researchers still lead the most prestigious teaching hospitals and the most trusted departments of psychiatry in the United States where the clinical directorate structure originated. It is also known that good scholars can improve research output when appointed to leadership positions. This suggests that the clinical director's research track record should be a consideration at a time when research is being embedded in Australia's local health networks. A clinical director's leadership may influence the research performance of their department and contribute to the quality of mental healthcare. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  3. Clinical Marine Toxicology: A European Perspective for Clinical Toxicologists and Poison Centers

    Directory of Open Access Journals (Sweden)

    Luc De Haro

    2013-08-01

    Full Text Available Clinical marine toxicology is a rapidly changing area. Many of the new discoveries reported every year in Europe involve ecological disturbances—including global warming—that have induced modifications in the chorology, behavior, and toxicity of many species of venomous or poisonous aquatic life including algae, ascidians, fish and shellfish. These changes have raised a number of public issues associated, e.g., poisoning after ingestion of contaminated seafood, envenomation by fish stings, and exposure to harmful microorganism blooms. The purpose of this review of medical and scientific literature in marine toxicology is to highlight the growing challenges induced by ecological disturbances that confront clinical toxicologists during the everyday job in the European Poison Centers.

  4. European Good Laboratory and Clinical Practices: their relevance to clinical pathology laboratories.

    Science.gov (United States)

    Dent, N J

    1991-10-01

    The requirements for Good Laboratory (GLP) and Good Clinical Practices (CGP) were established as a matter of urgency by the United States in the early 1970s. These were in response to gross misconduct and, in many instances, fraud. Over the next 15 years, a plethora of regulatory principles, guidelines, and regulations was produced by many countries of the world, culminating in single standards for European, Japanese, and United States authorities. Although with regard to GLP this has basically become a worldwide recognized standard within the preclinical (toxicology) studies, in the veterinary, chemical, agrochemical, and pharmaceutical industries, the GCPs are now seeing a rebirth. Within a clinical trials environment, there is most certainly a requirement for compliance with GCP, especially with regard to the harmonization of data within the European Community. The goal of this article is to cover the following aspects: Why should we have good practices? Why should laboratory data be audited? Why is there a need for a QA unit or function? What is the QA operational approach? How does a laboratory audit take place within laboratories? In discussing the laboratories and their subsequent data audits, the pitfalls and benefits are addressed and an examination of the data from the sponsor's viewpoint is compared with that produced by the laboratory. The types of laboratories present in a clinical environment are examined. They obviously comprise clinical pathology, microbiology, and analytical as well as ancillary hospital areas such as X-ray and cardiology. These laboratories may also be in the private sector, the National Health Service, contract laboratories, universities, or the general practitioner population.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Infectious Disease Clinical Research Program (IDCRP)

    Data.gov (United States)

    Federal Laboratory Consortium — Our mission is to conduct infectious disease clinical research of importance to the military through a unique, adaptive, and collaborative network, to inform health...

  6. European Cardiomyopathy Pilot Registry: EURObservational Research Programme of the European Society of Cardiology.

    Science.gov (United States)

    Elliott, Perry; Charron, Philippe; Blanes, Juan Ramon Gimeno; Tavazzi, Luigi; Tendera, Michal; Konté, Marème; Laroche, Cécile; Maggioni, Aldo P

    2016-01-07

    Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. Between 1 December 2012 and 30 November 2013, four cardiomyopathy phenotypes were studied: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM). Twenty-seven centres in 12 countries participated; 1115 patients were enrolled. The commonest cardiomyopathy was HCM (n = 681), followed by DCM (n = 346), ARVC (n = 59), and RCM (n = 29); 423 patients (46.4% of those reported) had familial disease; and 56 (5.0%) had rare disease phenocopies. Median age at enrolment and diagnosis was 54 [interquartile range (IQR), 42-64] and 46 years (IQR, 32-58), respectively; fewer patients with ARVC and more with RCM were diagnosed in the upper age quartile (P cardiomyopathies except RCM (P = 0.0023). Most patients were in New York Heart Association functional class I (n = 813) at enrolment; 139 (12.5%) reported syncope, most frequently in ARVC (P = 0.0009). Five hundred and seven (45.5%) patients underwent cardiac magnetic resonance imaging, 117 (10.6%) endomyocardial biopsy, and 462 (41.4%) genetic testing with a causative mutation reported in 236 individuals (51.1%). 1026 patients (92.0%) were receiving drug therapy; 316 (28.3%) had received an implantable cardioverter defibrillator (highest proportion in ARVC, P cardiomyopathy are complex, requiring access to a large range of invasive and non-invasive investigations and involvement of multidisciplinary teams. Treatment regimens are equally multifaceted and show that patients are likely to need long-term follow-up in close liaison with expert centres. Published on behalf of the European Society of Cardiology. All rights

  7. [Congress of European society of cardiology (amsterdam, 2013): new recommendations and most important clinical studies].

    Science.gov (United States)

    Kanorskiĭ, S G; Mamedov, M N

    2014-01-01

    In this review we present short report on European Congress of Cardiology which took place in Amsterdam from August 3 to September 4, 2013. Four new European recommendations on the treatment of cardiovascular diseases are briefly characterized and reports of Hot Line and Clinical Trial Update scientific sessions are presented.

  8. European AIDS Clinical Society Standard of Care meeting on HIV and related coinfections: The Rome Statements

    NARCIS (Netherlands)

    Mussini, C.; Antinori, A.; Bhagani, S.; Branco, T.; Brostrom, M.; Dedes, N.; Bereczky, T.; Girardi, E.; Gökengin, D.; Horban, A.; Lacombe, K.; Lundgren, J. D.; Mendao, L.; Mocroft, A.; Oprea, C.; Porter, K.; Podlekareva, D.; Battegay, M.; d'Arminio Monforte, A.; Mulcahy, Fiona; Geretti, Anna Maria; Clumeck, Nathan; Reiss, Peter; Arribas, Jose; Gatell, Jose; Katlama, Christine; Pozniak, Anton; Rockstroh, Jürgen; Youle, Mike; Friis-Møller, Nina; Rusconi, Stefano; Behrens, Georg; de Wit, Stéphane; Furrer, Hansjakob; Wensing, Annemarie; John Gill, M.; Letendre, Scott

    2016-01-01

    The objective of the 1st European AIDS Clinical Society meeting on Standard of Care in Europe was to raise awareness of the European scenario and come to an agreement on actions that could be taken in the future. Data-driven presentations were given on specific topics followed by interactive panel

  9. European AIDS Clinical Society Standard of Care meeting on HIV and related coinfections : The Rome Statements

    NARCIS (Netherlands)

    Mussini, C.; Antinori, A.; Bhagani, S.; Branco, T.; Brostrom, M.; Dedes, N.; Bereczky, T.; Girardi, E.; Gökengin, D.; Horban, A.; Lacombe, K.; Lundgren, J. D.; Mendao, L.; Mocroft, A.; Oprea, C.; Porter, K.; Podlekareva, D.; Battegay, M.; d'Arminio Monforte, A.; Mulcahy, Fiona; Geretti, Anna Maria; Clumeck, Nathan; Reiss, Peter; Arribas, Jose; Gatell, Jose; Katlama, Christine; Pozniak, Anton; Rockstroh, Jürgen; Youle, Mike; Friis-Møller, Nina; Rusconi, Stefano; Behrens, Georg; De Wit, Stéphane; Furrer, Hansjakob; Wensing, Annemarie|info:eu-repo/dai/nl/30817724X; John Gill, M.; Letendre, Scott

    2016-01-01

    Objectives: The objective of the 1st European AIDS Clinical Society meeting on Standard of Care in Europe was to raise awareness of the European scenario and come to an agreement on actions that could be taken in the future. Methods: Data-driven presentations were given on specific topics followed

  10. Construction of ethics in clinical research: clinical trials registration

    Directory of Open Access Journals (Sweden)

    C. A. Caramori

    2007-01-01

    Full Text Available Scientific development that has been achieved through decades finds in clinical research a great possibility of translating findings to human health application. Evidence given by clinical trials allows everyone to have access to the best health services. However, the millionaire world of pharmaceutical industries has stained clinical research with doubt and improbability. Study results (fruits of controlled clinical trials and scientific publications (selective, manipulated and with wrong conclusions led to an inappropriate clinical practice, favoring the involved economic aspect. In 2005, the International Committee of Medical Journal Editors (ICMJE, supported by the World Association of Medical Editors, started demanding as a requisite for publication that all clinical trials be registered at the database ClinicalTrials.gov. In 2006, the World Health Organization (WHO created the International Clinical Trial Registry Platform (ICTRP, which gathers several registry centers from all over the world, and required that all researchers and pharmaceutical industries register clinical trials. Such obligatory registration has progressed and will extend to all scientific journals indexed in all worldwide databases. Registration of clinical trials means another step of clinical research towards transparency, ethics and impartiality, resulting in real evidence to the forthcoming changes in clinical practice as well as in the health situation.

  11. Media | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The Office of Cancer Clinical Proteomics Research (OCCPR) is committed to providing the media with timely and accurate information.  This section offers key resources for patients, cancer researchers, physicians, and media professionals.

  12. Educational Research Capacity Building in the European Union: A Critique of the Lived Experiences of Emerging Researchers

    Science.gov (United States)

    Hallet, Fiona; Fidalgo, Patricia

    2014-01-01

    The purpose of this article is to explore the extent to which European Union (EU) policies impact upon the activities of associations such as the European Educational Research Association (EERA) and the experiences of emerging researchers aligned to such associations. In essence, the authors explore potential tensions between policy and the lived…

  13. Database on veterinary clinical research in homeopathy.

    Science.gov (United States)

    Clausen, Jürgen; Albrecht, Henning

    2010-07-01

    The aim of the present report is to provide an overview of the first database on clinical research in veterinary homeopathy. Detailed searches in the database 'Veterinary Clinical Research-Database in Homeopathy' (http://www.carstens-stiftung.de/clinresvet/index.php). The database contains about 200 entries of randomised clinical trials, non-randomised clinical trials, observational studies, drug provings, case reports and case series. Twenty-two clinical fields are covered and eight different groups of species are included. The database is free of charge and open to all interested veterinarians and researchers. The database enables researchers and veterinarians, sceptics and supporters to get a quick overview of the status of veterinary clinical research in homeopathy and alleviates the preparation of systematical reviews or may stimulate reproductions or even new studies. 2010 Elsevier Ltd. All rights reserved.

  14. Critical issues in clinical periodontal research.

    Science.gov (United States)

    Preshaw, Philip M

    2012-06-01

    As periodontal researchers and clinicians, we are challenged every day to make decisions relating to the clinical management of our patients and about how best to conduct clinical periodontal research. This volume of Periodontology 2000 addresses some of the critical issues in contemporary clinical periodontics and periodontal research that are of direct relevance to clinicians, researchers, teachers and students. The 11 review articles in this volume of Periodontology 2000 focus on aspects of periodontal research methodology and clinical periodontology. In terms of research methodology, the articles aim to inform the reader on topics relating to randomized controlled trials in periodontal research, evidence-based dentistry, calibration of clinical examiners and statistics relevant to periodontal research. The clinical periodontology articles address issues relating to decisions on retaining periodontally compromised teeth or replacing them with implants, periodontal management in the patient with osteoporosis, surgical approaches for root coverage and the emerging science of advanced regenerative technologies, including the use of stem cells, for periodontal regeneration. It is hoped that these critical reviews will address many of the dilemmas that confront us on a regular basis and provide practical guidance to those engaged in both clinical periodontology and clinical periodontal research. © 2012 John Wiley & Sons A/S.

  15. Study Designs in Clinical Research

    NARCIS (Netherlands)

    Noordzij, Marlies; Dekker, Friedo W.; Zoccali, Carmine; Jager, Kitty J.

    2009-01-01

    In nephrology research, both observational studies and randomized controlled trials (RCTs) are commonly applied. Clinicians using the evidence from epidemiological studies should be aware of the specific qualities and limitations of each study design. The purpose of the article is therefore to

  16. A possible biomedical facility at the European Organization for Nuclear Research (CERN).

    Science.gov (United States)

    Dosanjh, M; Jones, B; Myers, S

    2013-05-01

    A well-attended meeting, called "Brainstorming discussion for a possible biomedical facility at CERN", was held by the European Organization for Nuclear Research (CERN) at the European Laboratory for Particle Physics on 25 June 2012. This was concerned with adapting an existing, but little used, 78-m circumference CERN synchrotron to deliver a wide range of ion species, preferably from protons to at least neon ions, with beam specifications that match existing clinical facilities. The potential extensive research portfolio discussed included beam ballistics in humanoid phantoms, advanced dosimetry, remote imaging techniques and technical developments in beam delivery, including gantry design. In addition, a modern laboratory for biomedical characterisation of these beams would allow important radiobiological studies, such as relative biological effectiveness, in a dedicated facility with standardisation of experimental conditions and biological end points. A control photon and electron beam would be required nearby for relative biological effectiveness comparisons. Research beam time availability would far exceed that at other facilities throughout the world. This would allow more rapid progress in several biomedical areas, such as in charged hadron therapy of cancer, radioisotope production and radioprotection. The ethos of CERN, in terms of open access, peer-reviewed projects and governance has been so successful for High Energy Physics that application of the same to biomedicine would attract high-quality research, with possible contributions from Europe and beyond, along with potential new funding streams.

  17. Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey

    NARCIS (Netherlands)

    McKeag, David; Lane, Carol; Lazarus, John H.; Baldeschi, Lelio; Boboridis, Kostas; Dickinson, A. Jane; Hullo, A. Iain; Kahaly, George; Krassas, Gerry; Marcocci, Claudio; Marinò, Michele; Mourits, Maarten P.; Nardi, Marco; Neoh, Christopher; Orgiazzi, Jacques; Perros, Petros; Pinchera, Aldo; Pitz, Susanne; Prummel, Mark F.; Sartini, Maria S.; Wiersinga, Wilmar M.

    2007-01-01

    BACKGROUND: This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe. METHODS: Forty seven patients with DON presented to seven European centres during one year. Local protocols for thyroid status, ophthalmic examination and further investigation

  18. Chloracne: From clinic to research

    Directory of Open Access Journals (Sweden)

    Qiang Ju

    2012-03-01

    Full Text Available Chloracne is the most sensitive and specific marker for a possible dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin intoxication. It is clinically characterized by multiple acneiform comedone-like cystic eruptions mainly involving face in the malar, temporal, mandibular, auricular/retroauricular regions, and the genitalia, often occurring in age groups not typical for acne vulgaris. Histopathology is essential for a definite diagnosis, which exhibits atrophy or absence of sebaceous glands as well as infundibular dilatation or cystic formation of hair follicles, hyperplasia of epidermis, and hyperpigmentation of stratum corneum. The appearance of chloracne and its clinical severity does not correlate with the blood levels of dioxins. Pathogenesis of chloracne remains largely unclear. An “aryl hydrocarbon receptor”-mediated signaling pathway affecting the multipotent stem cells in the pilosebaceous units is probably the major molecular mechanism inducing chloracne. Chloracne is resistant to all the available treatment modalities used to treat acne. The aim of treatment is to lower or to eliminate the accumulated dioxins in the body at the very beginning of intoxication, e.g., by using dioxin-chelating substances such as synthetic dietary fat substitutes. The problem of dioxin contamination and its potential health hazards should be taken seriously in the wave of industrial globalization in the twenty-first century. Clinicians, especially dermatologists, are in the forefront of early diagnosis of dioxin intoxication.

  19. Antiphospholipid Syndrome Clinical Research Task Force Report

    NARCIS (Netherlands)

    Erkan, D.; Derksen, R.; Levy, R.; Machin, S.; Ortel, T.; Pierangeli, S.; Roubey, R.; Lockshin, M.

    The Antiphospholipid Syndrome (APS) Clinical Research Task Force (CRTF) was one of six Task Forces developed by the 13(th) International Congress on Antiphospholipid Antibodies (aPL) organization committee with the purpose of: a) evaluating the limitations of APS clinical research and developing

  20. An assessment of long term ecosystem research activities across European socio-ecological gradients

    NARCIS (Netherlands)

    Metzger, M.J.; Bunce, R.G.H.; Eupen, van M.; Mirtl, M.

    2010-01-01

    Integration of European long term ecosystem research (LTER) would provide important support for the management of the pan-European environment and ecosystems, as well as international policy commitments. This does require appropriate coverage of Europe and standardised frameworks and research

  1. The clinical applicability of music therapy research

    DEFF Research Database (Denmark)

    Wigram, Anthony Lewis

    Research serves the functions of informing the clinical field, guiding future research, establishing new knowledge and theory, and meeting criteria for evidence based practice. Given the demands of health, education and social services today and there is an increasing expectation that clinical...... managers, the objective, method, results, implications and limitations need to be clearly set out and argued. Examples of this will be drawn from various clinical fields, including psychiatry, developmental disability, neurology, paediatrics, pervasive developmental disorder and oncology, together...

  2. Measuring clinical management by physicians and nurses in European hospitals: development and validation of two scales

    Science.gov (United States)

    Plochg, Thomas; Arah, Onyebuchi A.; Botje, Daan; Thompson, Caroline A.; Klazinga, Niek S.; Wagner, Cordula; Mannion, Russell; Lombarts, Kiki; Klazinga, NS; Kringos, DS; Lombarts, MJMH; Plochg, T; Lopez, MA; Secanell, M; Sunol, R; Vallejo, P; Bartels, P; Kristensen, S; Michel, P; Saillour-Glenisson, F; Vlcek, F; Car, M; Jones, S; Klaus, E; Bottaro, S; Garel, P; Saluvan, M; Bruneau, C; Depaigne-Loth, A; Shaw, C; Hammer, A; Ommen, O; Pfaff, H; Groene, O; Botje, D; Wagner, C; Kutaj-Wasikowska, H; Kutryba, B; Escoval, A; Lívio, A; Eiras, M; Franca, M; Leite, I; Almeman, F; Kus, H; Ozturk, K; Mannion, R; Arah, OA; DerSarkissian, M; Thompson, CA; Wang, A; Thompson, A

    2014-01-01

    Objective Clinical management is hypothesized to be critical for hospital management and hospital performance. The aims of this study were to develop and validate professional involvement scales for measuring the level of clinical management by physicians and nurses in European hospitals. Design Testing of validity and reliability of scales derived from a questionnaire of 21 items was developed on the basis of a previous study and expert opinion and administered in a cross-sectional seven-country research project ‘Deepening our Understanding of Quality improvement in Europe’ (DUQuE). Setting and Participants A sample of 3386 leading physicians and nurses working in 188 hospitals located in Czech Republic, France, Germany, Poland, Portugal, Spain and Turkey. Main Outcome Measures Validity and reliability of professional involvement scales and subscales. Results Psychometric analysis yielded four subscales for leading physicians: (i) Administration and budgeting, (ii) Managing medical practice, (iii) Strategic management and (iv) Managing nursing practice. Only the first three factors applied well to the nurses. Cronbach's alpha for internal consistency ranged from 0.74 to 0.86 for the physicians, and from 0.61 to 0.81 for the nurses. Except for the 0.74 correlation between ‘Administration and budgeting’ and ‘Managing medical practice’ among physicians, all inter-scale correlations were management roles’ of physicians and nurses. Conclusions The professional involvement scales appear to yield reliable and valid data in European hospital settings, but the scale ‘Managing medical practice’ for nurses needs further exploration. The measurement instrument can be used for international research on clinical management. PMID:24615595

  3. Randomized Clinical Trials in Stroke Research

    OpenAIRE

    Ahn, Chul; Ahn, Daniel

    2010-01-01

    A randomized clinical trial (RCT) is widely regarded as the most rigorous study design to determine the efficacy of intervention since spurious causality and bias associated with other experimental designs can be avoided. The purpose of this article is to provide clinicians and clinical researchers with the types of randomized clinical trials used in stroke studies and to discuss the advantages and limitations in each type of randomized stroke clinical trials.

  4. A European Perspective on Auditory Processing Disorder-Current Knowledge and Future Research Focus

    Science.gov (United States)

    Iliadou, Vasiliki (Vivian); Ptok, Martin; Grech, Helen; Pedersen, Ellen Raben; Brechmann, André; Deggouj, Naïma; Kiese-Himmel, Christiane; Śliwińska-Kowalska, Mariola; Nickisch, Andreas; Demanez, Laurent; Veuillet, Evelyne; Thai-Van, Hung; Sirimanna, Tony; Callimachou, Marina; Santarelli, Rosamaria; Kuske, Sandra; Barajas, Jose; Hedjever, Mladen; Konukseven, Ozlem; Veraguth, Dorothy; Stokkereit Mattsson, Tone; Martins, Jorge Humberto; Bamiou, Doris-Eva

    2017-01-01

    Current notions of “hearing impairment,” as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other more sophisticated audiometric tests such as speech audiometry in noise or complex non-speech sound perception. This disorder, defined as “Auditory Processing Disorder” (APD) or “Central Auditory Processing Disorder” is classified in the current tenth version of the International Classification of diseases as H93.25 and in the forthcoming beta eleventh version. APDs may have detrimental effects on the affected individual, with low esteem, anxiety, and depression, and symptoms may remain into adulthood. These disorders may interfere with learning per se and with communication, social, emotional, and academic-work aspects of life. The objective of the present paper is to define a baseline European APD consensus formulated by experienced clinicians and researchers in this specific field of human auditory science. A secondary aim is to identify issues that future research needs to address in order to further clarify the nature of APD and thus assist in optimum diagnosis and evidence-based management. This European consensus presents the main symptoms, conditions, and specific medical history elements that should lead to auditory processing evaluation. Consensus on definition of the disorder, optimum diagnostic pathway, and appropriate management are highlighted alongside a perspective on future research focus.

  5. A European Perspective on Auditory Processing Disorder-Current Knowledge and Future Research Focus

    Directory of Open Access Journals (Sweden)

    Vasiliki (Vivian Iliadou

    2017-11-01

    Full Text Available Current notions of “hearing impairment,” as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other more sophisticated audiometric tests such as speech audiometry in noise or complex non-speech sound perception. This disorder, defined as “Auditory Processing Disorder” (APD or “Central Auditory Processing Disorder” is classified in the current tenth version of the International Classification of diseases as H93.25 and in the forthcoming beta eleventh version. APDs may have detrimental effects on the affected individual, with low esteem, anxiety, and depression, and symptoms may remain into adulthood. These disorders may interfere with learning per se and with communication, social, emotional, and academic-work aspects of life. The objective of the present paper is to define a baseline European APD consensus formulated by experienced clinicians and researchers in this specific field of human auditory science. A secondary aim is to identify issues that future research needs to address in order to further clarify the nature of APD and thus assist in optimum diagnosis and evidence-based management. This European consensus presents the main symptoms, conditions, and specific medical history elements that should lead to auditory processing evaluation. Consensus on definition of the disorder, optimum diagnostic pathway, and appropriate management are highlighted alongside a perspective on future research focus.

  6. Modern Clinical Research on LSD

    Science.gov (United States)

    Liechti, Matthias E

    2017-01-01

    All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. There were five recent studies in healthy participants and one in patients. In a controlled setting, LSD acutely induced bliss, audiovisual synesthesia, altered meaning of perceptions, derealization, depersonalization, and mystical experiences. These subjective effects of LSD were mediated by the 5-HT2A receptor. LSD increased feelings of closeness to others, openness, trust, and suggestibility. LSD impaired the recognition of sad and fearful faces, reduced left amygdala reactivity to fearful faces, and enhanced emotional empathy. LSD increased the emotional response to music and the meaning of music. LSD acutely produced deficits in sensorimotor gating, similar to observations in schizophrenia. LSD had weak autonomic stimulant effects and elevated plasma cortisol, prolactin, and oxytocin levels. Resting-state functional magnetic resonance studies showed that LSD acutely reduced the integrity of functional brain networks and increased connectivity between networks that normally are more dissociated. LSD increased functional thalamocortical connectivity and functional connectivity of the primary visual cortex with other brain areas. The latter effect was correlated with subjective hallucinations. LSD acutely induced global increases in brain entropy that were associated with greater trait openness 14 days later. In patients with anxiety associated with life-threatening disease, anxiety was reduced for 2 months after two doses of LSD. In medical settings, no complications of LSD administration were observed. These data should contribute to further investigations of the therapeutic potential of LSD in psychiatry. PMID:28447622

  7. Training needs of clinical research associates

    Directory of Open Access Journals (Sweden)

    Samyuktha Ajay

    2010-01-01

    Full Text Available Clinical research is a relatively new field in our country that has seen very rapid growth in the last few years. Availability of personnel appropriately trained to the specific requirements of the role they will perform in clinical research is critical for capacity expansion. Our study attempts to understand the specific areas of knowledge and skills that are important for the role of a clinical research associate. The survey was conducted among clinical research professionals from industry and academia who had more than five years of clinical research experience and held important decision making positions in clinical research (stakeholders. The survey questionnaire was designed as a matrix of various clinical research roles on the y-axis and six knowledge modules and eight skills on the x-axis. Respondents were asked to rate the importance of the knowledge /skills to the role of clinical research associates on a three point scale. In discussing results, a significant response was considered to be 50% or greater positive response from the total group. The significant findings were that general, ethics and clinical trial execution modules were rated as critical for the role of clinical research associate. Regulatory module was rated as important for the role. The other significant responses were that three of the sub-topics in the methodology module - framing a research proposal/protocol and experimental design, designing case report forms and EDCs and conducting PK studies - were rated as important and one sub topic in the data management and statistics module was rated as not important. All the skills except leadership skills were rated as critical for the role. The findings of our survey were in general on the lines of expectations of performance of the role. The general, ethics and clinical trial execution modules are critical knowledge areas for the role of a clinical research associate. No clear trends emerged for some of the other

  8. European network infrastructures of observatories for terrestrial Global Change research

    Science.gov (United States)

    Vereecken, H.; Bogena, H.; Lehning, M.

    2009-04-01

    The earth's climate is significantly changing (e.g. IPCC, 2007) and thus directly affecting the terrestrial systems. The number and intensity hydrological extremes, such as floods and droughts, are continually increasing, resulting in major economical and social impacts. Furthermore, the land cover in Europe has been modified fundamentally by conversions for agriculture, forest and for other purposes such as industrialisation and urbanisation. Additionally, water resources are more than ever used for human development, especially as a key resource for agricultural and industrial activities. As a special case, the mountains of the world are of significant importance in terms of water resources supply, biodiversity, economy, agriculture, traffic and recreation but particularly vulnerable to environmental change. The Alps are unique because of the pronounced small scale variability they contain, the high population density they support and their central position in Europe. The Alps build a single coherent physical and natural environment, artificially cut by national borders. The scientific community and governmental bodies have responded to these environmental changes by performing dedicated experiments and by establishing environmental research networks to monitor, analyse and predict the impact of Global Change on different terrestrial systems of the Earths' environment. Several European network infrastructures for terrestrial Global Change research are presently immerging or upgrading, such as ICOS, ANAEE, LifeWatch or LTER-Europe. However, the strongest existing networks are still operating on a regional or national level and the historical growth of such networks resulted in a very heterogeneous landscape of observation networks. We propose therefore the establishment of two complementary networks: The NetwOrk of Hydrological observAtories, NOHA. NOHA aims to promote the sustainable management of water resources in Europe, to support the prediction of

  9. A bibliometric analysis of global clinical research by anesthesia departments.

    Science.gov (United States)

    Swaminathan, Madhav; Phillips-Bute, Barbara G; Grichnik, Katherine P

    2007-12-01

    Few studies have investigated the diversity in research conducted by anesthesia-based researchers. We examined global clinical research attributed to anesthesia departments using Medline and Ovid databases. We also investigated the impact of economic development on national academic productivity. We conducted a Medline search for English-language publications from 2000 to 2005. The search included only clinical research in which institutional affiliation included words relating to anesthesia (e.g., anesthesiology, anesthesia, etc.). Population and gross national income data were obtained from publicly available databases. Impact factors for journals were obtained from Journal Citation Reports (Thomson Scientific). There were 6736 publications from 64 countries in 551 journals. About 85% of all publications were represented by 46 journals. Randomized controlled trials constituted 4685 (70%) of publications. Turkey had the highest percentage of randomized controlled trials (88%). The United States led the field in quantity (20% of total) and mean impact factor (3.0) of publications. Finland had the highest productivity when adjusted for population (36 publications per million population). Publications from the United States declined from 23% in 2000 to 17% in 2005. Clinical research attributable to investigators in our specialty is diverse, and extends beyond the traditional field of anesthesia and intensive care. The United States produces the most clinical research, but per capita output is higher in European nations.

  10. Building the European Research Area in nuclear fission pioneering steps in actinide science

    Energy Technology Data Exchange (ETDEWEB)

    Forsstroem, Hans

    2004-07-01

    The concept of the European Research Area (ERA) aims at closer development of research policies in Europe and closer networking of research capacities, to reduce fragmentation of research in Europe. The goal is to make European research more effective and competitive. Several approaches are made to create ERA. The European Research Framework Programme is one tool in this context, with the introduction of the new instruments, Integrated Projects, Networks of Excellence and Integrated Infrastructure Initiatives. Actinide science is one area that could benefit from better coordination and more effective use of the research capacities, both human and physical. The European Commission is thus funding a Network of Excellence (ACTINET-6) and an Integrated Project (EUROPART) in this area within the sixth EURATOM Framework Programme. (author)

  11. TOPIC: CLINICAL NURSING RESEARCH: A TOOL FOR ...

    African Journals Online (AJOL)

    DR. MRS. AKPABIO

    Good Clinical Practice guidelines. SM 13: Collecting data on research participants, based on study endpoints. SM 14: Facilitating scheduling and coordination of study procedures. SM 15: Providing nursing expertise to the research team during study development and implementation. SM 16: Protecting research participants ...

  12. 119 Research Article Resistance to European Penetration into Africa ...

    African Journals Online (AJOL)

    2017-06-22

    Jun 22, 2017 ... Resistance to European Penetration into Africa:The case of the North West Region of Cameroon. MATHEW .... French from their colonial territories in the East ..... men and women. They arrived at Bangante and were not received by Chief Nana and so he continued south-but was attacked by the people.

  13. The European standard series. European Environmental and Contact Dermatitis Research Group (EECDRG)

    DEFF Research Database (Denmark)

    Bruynzeel, D P; Andersen, Klaus Ejner; Camarasa, J G

    1995-01-01

    Changes to the European standard series which have taken place since the last officially recommended alterations in 1988, are explained. New to the series is the sesquiterpene lactone mix. The PPD black rubber mix and the quinoline mix have been replaced by single components; one of the p-hydroxy......-hydroxybenzoates has been left out of the paraben mix. Ethylenediamine dihydrochloride has been dropped from the series....

  14. Translating research findings to clinical nursing practice.

    Science.gov (United States)

    Curtis, Kate; Fry, Margaret; Shaban, Ramon Z; Considine, Julie

    2017-03-01

    To describe the importance of, and methods for, successfully conducting and translating research into clinical practice. There is universal acknowledgement that the clinical care provided to individuals should be informed on the best available evidence. Knowledge and evidence derived from robust scholarly methods should drive our clinical practice, decisions and change to improve the way we deliver care. Translating research evidence to clinical practice is essential to safe, transparent, effective and efficient healthcare provision and meeting the expectations of patients, families and society. Despite its importance, translating research into clinical practice is challenging. There are more nurses in the frontline of health care than any other healthcare profession. As such, nurse-led research is increasingly recognised as a critical pathway to practical and effective ways of improving patient outcomes. However, there are well-established barriers to the conduct and translation of research evidence into practice. This clinical practice discussion paper interprets the knowledge translation literature for clinicians interested in translating research into practice. This paper is informed by the scientific literature around knowledge translation, implementation science and clinician behaviour change, and presented from the nurse clinician perspective. We provide practical, evidence-informed suggestions to overcome the barriers and facilitate enablers of knowledge translation. Examples of nurse-led research incorporating the principles of knowledge translation in their study design that have resulted in improvements in patient outcomes are presented in conjunction with supporting evidence. Translation should be considered in research design, including the end users and an evaluation of the research implementation. The success of research implementation in health care is dependent on clinician/consumer behaviour change and it is critical that implementation strategy

  15. An official American Thoracic Society/European Respiratory Society statement: research questions in COPD.

    Science.gov (United States)

    Celli, Bartolome R; Decramer, Marc; Wedzicha, Jadwiga A; Wilson, Kevin C; Agustí, Alvar; Criner, Gerard J; MacNee, William; Make, Barry J; Rennard, Stephen I; Stockley, Robert A; Vogelmeier, Claus; Anzueto, Antonio; Au, David H; Barnes, Peter J; Burgel, Pierre-Regis; Calverley, Peter M; Casanova, Ciro; Clini, Enrico M; Cooper, Christopher B; Coxson, Harvey O; Dusser, Daniel J; Fabbri, Leonardo M; Fahy, Bonnie; Ferguson, Gary T; Fisher, Andrew; Fletcher, Monica J; Hayot, Maurice; Hurst, John R; Jones, Paul W; Mahler, Donald A; Maltais, François; Mannino, David M; Martinez, Fernando J; Miravitlles, Marc; Meek, Paula M; Papi, Alberto; Rabe, Klaus F; Roche, Nicolas; Sciurba, Frank C; Sethi, Sanjay; Siafakas, Nikos; Sin, Don D; Soriano, Joan B; Stoller, James K; Tashkin, Donald P; Troosters, Thierry; Verleden, Geert M; Verschakelen, Johny; Vestbo, Jorgen; Walsh, John W; Washko, George R; Wise, Robert A; Wouters, Emiel F M; ZuWallack, Richard L

    2015-04-01

    Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) research statement is to describe evidence related to diagnosis, assessment and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified. Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS research statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centred outcomes. Copyright ©ATS/ERS 2015.

  16. An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

    Directory of Open Access Journals (Sweden)

    Bartolome R. Celli

    2015-06-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a leading cause of morbidity, mortality and resource use worldwide. The goal of this official American Thoracic Society (ATS/European Respiratory Society (ERS Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Clinicians, researchers and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified. Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS research statement highlights the types of research that leading clinicians, researchers and patient advocates believe will have the greatest impact on patient-centred outcomes.

  17. Drug delivery research in the European Union's Seventh Framework Programme for Research.

    Science.gov (United States)

    Frima, Heico J; Gabellieri, Cristina; Nilsson, Maj-Inger

    2012-07-20

    This paper presents an overview of drug delivery research activities funded by the European Union's Seventh Framework Programme for Research and Technological Development (FP7). It gives a brief introduction of the main policies, structure and budget of FP7 with the four Specific Programmes 'Cooperation', 'People', 'Ideas' and 'Capacities' including the ten priority themes of the Specific Programme Cooperation. The priority themes HEALTH, 'Information and Communication Technologies' (ICT) and 'Nanosciences and nanotechnologies, multifunctional Materials and Production technologies' (NMP) and the 'Innovative Medicines Initiative' (IMI) are discussed since they are the main sources of funding for medical and pharmaceutical research. Further details are provided on drug delivery research, notably the funding for development of drug delivery technologies by the NMP priority theme in the context of its funding of nanomedicine research projects. The link is made to the rapidly developing field of biomaterials research for implants and regenerative medicine. The paper highlights the strategic importance of the Key Emerging Technologies (KETs) including nanotechnology for the competitiveness of the medical and pharmaceutical sectors. Finally, there is an outlook to the future Framework Programme for Research 'Horizon 2020'. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. Quantitative Pathology: Historical Background, Clinical Research ...

    African Journals Online (AJOL)

    Quantitative Pathology: Historical Background, Clinical Research and Application of Nuclear Morphometry and DNA Image Cytometry. A Buhmeida. Abstract. No Abstract Keywords: quantitative, pathology, nuclear, morphometry, cytometry, histogram. Libyan Journal of Medicine Vol. 1 (2) 2006: pp. 126-139.

  19. Research on organized crime in Western Europe – 4th research conference “OC Research in Western European states” in Wiesbaden

    NARCIS (Netherlands)

    Töttel, U.; Bulanova-Hristova, G.; Kleemans, E.R.

    2012-01-01

    The 4th Research Conference "OC research in Western European States" took place in November 2011 in Wiesbaden. The conference was organized by the Bundeskriminalamt and is part of the project "International Research Network on Organized Crime", funded by the European Commission in the framework of

  20. Virtual microscopy in medical research: Open European Nephrology Science Center (OpEN.SC)

    Science.gov (United States)

    Schrader, Thomas; Beil, Michael; Schmidt, Danilo; Dietel, Manfred; Lindemann, Gabriela

    2007-03-01

    The amount and heterogeneity of data in biomedical research, notably in transnational research, requires new methods for the collection, presentation and analysis of information. Important data from laboratory experiments as well as patient trials are available as images. Thus, the integration and processing of image data represent a crucial component of information systems in biomedical research. The Charité Medical School in Berlin has established a new information service center for kidney diseases and transplantation (Open European Nephrology Science Centre - OpEN.SC) together with the German Research Agency (DFG). The aims of this project are (i) to improve the availability of raw data, (ii) to establish an infrastructure for clinical trials, (iii) to monitor the occurrence of rare disease patterns and (iv) to establish a quality assurance system. Major diagnostic procedures in medicine are based on the processing and analysis of image data. In diagnostic pathology, the availability of automated slide scanners provide the opportunity to digitize entire microscopic slides. The processing, presentation and analysis of these image data are called virtual microscopy. The integration of this new technology into the OpEN.SC system and the link to other heterogeneous data of individual patients represent a major technological challenge. Thus, new ways in communication between clinical and scientific partners have to be established and will be promoted by the project. The technological basis of the repository are web services for a scalable and adaptable system. HL7 and DICOM are considered the main medical standards of communication.

  1. Transcutaneous bilirubinometer: an instrument for clinical research.

    Science.gov (United States)

    Brown, L; Arnold, L; Charsha, D; Allison, D; Klein, H

    1990-01-01

    The transcutaneous bilirubinometer can be an effective instrument for clinical research. With neonatal jaundice occurring in approximately 50-75% of newborns, nurse researchers investigating many important issues surrounding this commonly occurring condition will find the bilirubinometer useful in screening for jaundice, testing effectiveness of various therapeutic modalities, and evaluating clinical progress. This article presents a review of the literature reporting reliability and validity of meter findings and makes recommendations for meter use.

  2. Qualitative Clinical Research with Children and Adolescents

    Science.gov (United States)

    Nelson, Mary Lee; Quintana, Stephen M.

    2005-01-01

    This article provides an overview of how qualitative research methods (QRMs) can augment the literature in child and adolescent clinical psychology by contributing to theory and hypothesis building. We discuss the utility of qualitative methods in examining the nature of clinical processes and obtaining deeper understandings about quantitative…

  3. The European Repository Landscape 2008 : Inventory of Digital Repositories for Research Output

    NARCIS (Netherlands)

    Van der Graaf, Maurits

    2009-01-01

    It is widely acknowledged that a common knowledge base for European research is necessary. The DRIVER project aims towards this. European practices may be harmonised and the development of stateof-the-art technology facilitated. As a first step, a clear picture of the state-of-the-art of the

  4. MUPBED: A Pan-European Prototype for Multi-Domain Research Networks

    DEFF Research Database (Denmark)

    Spaeth, Jan; Cavazzoni, Carlo; Foisel, Hans-Martin

    2009-01-01

    Integration and full interoperability are challenging areas of research in wide-area networks today. A European project, MUPBED, has recently concluded and achieved the main result of integrating and demonstrating technologies and network solutions that enable the operation of future European res...

  5. Overview and status of the Next European Dipole Joint Research Activity

    NARCIS (Netherlands)

    Devred, A.; Baudouy, B.; Baynham, D.E.; Boutboul, T.; Canfer, S.; Chorowski, M; Fabbricatore, P.; Farinon, S.; den Ouden, A.; van Weelderen, R.; Vedrine, P.; Volpini, G.

    2006-01-01

    The Next European Dipole (NED) Joint Research Activity was launched on 1 January 2004 to promote the development of high-performance Nb3Sn conductors in collaboration with European industry (aiming at a non-copper critical current density of 1500 A mm−2 at 4.2 K and 15 T) and to assess the

  6. Anaphylaxis : Guidelines from the European Academy of Allergy and Clinical Immunology

    NARCIS (Netherlands)

    Muraro, A.; Roberts, G.; Worm, M.; Bilo, M. B.; Brockow, K.; Fernandez Rivas, M.; Santos, A. F.; Zolkipli, Z. Q.; Bellou, A.; Beyer, K.; Bindslev-Jensen, C.; Cardona, V.; Clark, A. T.; Demoly, P.; Dubois, A. E. J.; DunnGalvin, A.; Eigenmann, P.; Halken, S.; Harada, L.; Lack, G.; Jutel, M.; Niggemann, B.; Rueff, F.; Timmermans, F.; Vlieg-Boerstra, B. J.; Werfel, T.; Dhami, S.; Panesar, S.; Akdis, C. A.; Sheikh, A.

    Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide

  7. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology

    NARCIS (Netherlands)

    Muraro, A.; Roberts, G.; Worm, M.; Bilò, M. B.; Brockow, K.; Fernández Rivas, M.; Santos, A. F.; Zolkipli, Z. Q.; Bellou, A.; Beyer, K.; Bindslev-Jensen, C.; Cardona, V.; Clark, A. T.; Demoly, P.; Dubois, A. E. J.; DunnGalvin, A.; Eigenmann, P.; Halken, S.; Harada, L.; Lack, G.; Jutel, M.; Niggemann, B.; Ruëff, F.; Timmermans, F.; Vlieg-Boerstra, B. J.; Werfel, T.; Dhami, S.; Panesar, S.; Akdis, C. A.; Sheikh, A.

    2014-01-01

    Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide

  8. Association of Systemic Lupus Erythematosus Clinical Features with European Population Genetic Substructure

    NARCIS (Netherlands)

    Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Witte, Torsten; Papasteriades, Chryssa; Marchini, Maurizio; Migliaresi, Sergio; Kovacs, Attila; Ordi-Ros, Josep; Bijl, Marc; Santos, Maria Jose; Ruzickova, Sarka; Pullmann, Rudolf; Carreira, Patricia; Skopouli, Fotini N.; D'Alfonso, Sandra; Sebastiani, Gian Domenico; Suarez, Ana; Blanco, Francisco J.; Gomez-Reino, Juan J.; Gonzalez, Antonio

    2011-01-01

    Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population

  9. The Cardiology Audit and Registration Data Standards (CARDS), European data standards for clinical cardiology practice

    NARCIS (Netherlands)

    M.R. Flynn (Rachel); C. Barrett (Conor); F.G. Cosio (Francisco); A.K. Gitt (Anselm); L.C. Wallentin (Lars); P. Kearney (Peter); M. Lonergan (Moira); E. Shelley (Emer); M.L. Simoons (Maarten)

    2005-01-01

    textabstractAIMS: Systematic registration of data from clinical practice is important for clinical care, local, national and international registries, and audit. Data to be collected for these different purposes should be harmonized. Therefore, during Ireland's Presidency of the European Union (EU)

  10. Converging clinical and engineering research on neurorehabilitation

    CERN Document Server

    Torricelli, Diego; Pajaro, Marta

    2013-01-01

    Restoring human motor and cognitive function has been a fascinating research area during the last century. Interfacing the human nervous system with electro-mechanical rehabilitation machines is facing its crucial passage from research to clinical practice, enhancing the potentiality of therapists, clinicians and researchers to rehabilitate, diagnose and generate knowledge. The 2012 International Conference on Neurorehabilitation (ICNR2012, www.icnr2012.org) brings together researchers and students from the fields of Clinical Rehabilitation, Applied Neurophysiology and Biomedical Engineering, covering a wide range of research topics:   · Clinical Impact of Technology · Brain-Computer Interface in Rehabilitation · Neuromotor & Neurosensory modeling and processing · Biomechanics in Rehabilitation · Neural Prostheses in Rehabilitation · Neuro-Robotics in Rehabilitation · Neuromodulation   This Proceedings book includes general contributions from oral and poster sessions, as well as from special sess...

  11. Clinical research priorities in emergency medicine.

    Science.gov (United States)

    Keijzers, Gerben; Thom, Ogilvie; Taylor, David; Knott, Jonathan; Taylor, David McD

    2014-02-01

    To determine the clinical research priorities of Fellows of the Australasian College for Emergency Medicine (ACEM) in order to inform the strategic research agenda specific to multicentre clinical research. An anonymous survey of all ACEM Fellows (FACEMs) listed on the ACEM researcher database was conducted between January and March 2013. Of 108 FACEMs invited to participate, 54 (50%) responded. Over half of respondents (61%) had a higher research degree but only a minority (24%) had funded research positions. The top research categories identified as priorities were resuscitation, trauma, cardiology, ED ultrasound, acute behavioural disturbance and geriatrics. The most common specific sub-categories included anterior chest pain, fluid resuscitation in trauma, and drug therapy for both atrial fibrillation and acute behavioural disturbance. Several specific research questions related to chest pain, resuscitation/sepsis, stroke, paediatrics and pulmonary embolus. The findings provide guidance and support for research areas amenable to collaborative multicentre clinical research within emergency medicine. Discussion rounds are planned to translate these perceived research priorities to actual priorities. © 2013 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  12. Charities' response to the European Commission call of interest for their involvement in the European Research Area

    CERN Document Server

    Sessano, D.

    2003-01-01

    This paper presents an exploratory study to investigate what could be the role of the charities concerned with scientific research in the European Research Area (ERA). The analysis particularly concentrates on UK and Italy. The questions on which the exploratory study was developed are: 1. “In what specific areas of the ERA did the European Commission (EC) for the involvement of charities? And could there be other areas in which charities might participate?” 2. “Given the role and situation of charities in UK and Italy, what role, if any, could they be willing to play in the ERA? Is it the same as the one proposed by the Commission or not?” In order to answer these questions, the following discussion will focus at first on a short overview of the charity sector, both at the general level and at the national level in UK and Italy. Then a brief presentation of the European Research Area will be given. The hypotheses of the study will then be presented, followed by a methodological section. Results wi...

  13. The impact of European research ethics legislation on UK radiology research activity: a bibliometric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, C.A. [Norwich Radiology Academy, Norwich (United Kingdom)], E-mail: Catherine.johnson@nnuh.nhs.uk; Toms, A.P. [Norwich Radiology Academy, Norwich (United Kingdom)

    2009-10-15

    Aim: To determine whether there is evidence of a reduction in radiology research activity in the UK following the implementation of the European research ethics legislation, which came in to force in 2001 and has been widely criticised as an impediment to research. Materials and methods: A bibliometric analysis was performed by searching PubMed for all first-author publications from UK departments of 'radiology' or 'medical imaging' between 1995 and 2007. Results were subcategorized into those papers published in the highest cited general radiology journals and by publication type: original research, reviews, and case reports. Results: From 1995 to 2007 the total number of publications rose by 6.5% from 137 to 146 with the increase occurring in non-general radiology journals. Original articles fell from 18 in 1995 to 12 in 2003, but then rose to 24 by 2007 (33% rise). This dip was paralleled by a fall and then recovery in case report publications. The most dramatic change has been in the number of review articles, which has increased more than eightfold from seven in 1995 to 65 in 2007 to become the most common form of publication. Conclusion: The overall number of original scientific articles, published by first-author UK radiologists, has increased slightly over the last 12 years despite a temporary fall associated with the introduction of new research ethics legislation.

  14. Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8–10 October 2010.

    Science.gov (United States)

    Steckelings, U Muscha; De Mey, Jo G R; Pinto-Sietsma, Sara-Joan; Henrion, Daniel; Unger, Thomas

    2011-01-01

    The 15th Annual Meeting of the European Council of Cardiovascular Research brought together basic and clinical scientists working in the cardiovascular field in La Colle sur Loup, France. Upfront basic and clinical research addressing the mechanisms of disease, identification of biomarkers or development of new treatments was communicated in 101 presentations, 35 of them as a part of five on-topic oral sessions and three workshops. Three keynote lectures reviewed current knowledge and the latest data about mechanosensitive channels in pressure regulation, cell therapy in cardiovascular disease and mechanisms of cardiovascular risk associated with diabetic nephropathy. This article summarizes highlights of the oral sessions, workshops and keynote lectures.

  15. Research Issues in Clinical Data Warehousing

    DEFF Research Database (Denmark)

    Pedersen, Torben Bach; Jensen, Christian Søndergaard

    1998-01-01

    to data warehousing technologies, over those posed by conventional data warehouse applications. This article presents a number of exciting new research challenges posed by clinical applications, to be met by the database research community. These include the need for complex-data modeling features......, advanced temporal support, advanced classification structures, continuously valued data, dimensionally reduced data, and the integration of very complex data. In addition, the support for clinical treatment protocols and medical research are interesting areas for research.......Medical informatics has been an important area for the application of computing and database technology for at least four decades. This area may benefit from the functionality offered by data warehousing. However, the special nature of clinical applications poses different and new requirements...

  16. Transitioning from Clinical to Qualitative Research Interviewing

    Directory of Open Access Journals (Sweden)

    Matthew R. Hunt BSc (PT, PhD

    2011-09-01

    Full Text Available In this paper one aspect of the transition that must be made by experienced clinicians who become involved in conducting qualitative health research is examined, specifically, the differences between clinical and research interviewing. A clinician who is skillful and comfortable carrying out a clinical interview may not initially apprehend the important differences between these categories and contexts of interviewing. This situation can lead to difficulties and diminished quality of data collection because the purpose, techniques and orientation of a qualitative research interview are distinct from those of the clinical interview. Appreciation of these differences between interview contexts and genres, and strategies for addressing challenges associated with these differences, can help clinician researchers to become successful qualitative interviewers.

  17. The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: guide to the Register, version 3-2010

    DEFF Research Database (Denmark)

    McMurray, Janet; Zérah, Simone; Hallworth, Michael

    2010-01-01

    In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 12 years, more...... than 2200 specialists in Clinical Chemistry and Laboratory Medicine have joined the Register. In 2007, EC4 merged with the Forum of European Societies of Clinical Chemistry and Laboratory Medicine (FESCC) to form the European Federation of Clinical Chemistry and Laboratory Medicine (EFCC). Two previous...

  18. Science on the net: an analysis of the websites of the European public research institutions

    National Research Council Canada - National Science Library

    Laura Massoli

    2007-01-01

    This article introduces a study on the websites of several European public research institutions that aims at identifying the science communication model chosen and implemented online with the purpose...

  19. An electronic delphi study to establish pediatric intensive care nursing research priorities in twenty European countries*

    NARCIS (Netherlands)

    Tume, Lyvonne N.; van den Hoogen, Agnes; Wielenga, Joke M.; Latour, Jos M.

    2014-01-01

    To identify and to establish research priorities for pediatric intensive care nursing science across Europe. A modified three-round electronic Delphi technique was applied. Questionnaires were translated into seven different languages. European PICUs. The participants included pediatric intensive

  20. Electronic health records to facilitate clinical research.

    Science.gov (United States)

    Cowie, Martin R; Blomster, Juuso I; Curtis, Lesley H; Duclaux, Sylvie; Ford, Ian; Fritz, Fleur; Goldman, Samantha; Janmohamed, Salim; Kreuzer, Jörg; Leenay, Mark; Michel, Alexander; Ong, Seleen; Pell, Jill P; Southworth, Mary Ross; Stough, Wendy Gattis; Thoenes, Martin; Zannad, Faiez; Zalewski, Andrew

    2017-01-01

    Electronic health records (EHRs) provide opportunities to enhance patient care, embed performance measures in clinical practice, and facilitate clinical research. Concerns have been raised about the increasing recruitment challenges in trials, burdensome and obtrusive data collection, and uncertain generalizability of the results. Leveraging electronic health records to counterbalance these trends is an area of intense interest. The initial applications of electronic health records, as the primary data source is envisioned for observational studies, embedded pragmatic or post-marketing registry-based randomized studies, or comparative effectiveness studies. Advancing this approach to randomized clinical trials, electronic health records may potentially be used to assess study feasibility, to facilitate patient recruitment, and streamline data collection at baseline and follow-up. Ensuring data security and privacy, overcoming the challenges associated with linking diverse systems and maintaining infrastructure for repeat use of high quality data, are some of the challenges associated with using electronic health records in clinical research. Collaboration between academia, industry, regulatory bodies, policy makers, patients, and electronic health record vendors is critical for the greater use of electronic health records in clinical research. This manuscript identifies the key steps required to advance the role of electronic health records in cardiovascular clinical research.

  1. [Social aspect of clinical research in Poland].

    Science.gov (United States)

    Masełbas, Wojciech; Czarkowski, Marek

    2007-12-01

    Each year more than 400 new clinical studies are registered in Poland. They gather above 50.000 of study participants. Social opinion on clinical trials is an important factor. The paper presents the review of actual opinions on clinical research in Poland. It provides the description of standards of protection of study participants, benefits and risks related to the participation in clinical research and the role of media in creating and influencing of the social perception of clinical trials. Results of conducted questionnaire studies imply that Poles correctly identify and assess the risk of participation in clinical experiments. The primary reason for the participation seams to be the possibility to help other patients, contribution to the progress of science and standards of medical care and potential benefits for other sufferers. The need of testing the safety and efficacy of the new medication in man is generally well recognized. At the same time a substantial part of the society is concerned with the possible corruption of investigators and unethical behaviour of sponsors. The social perception of clinical research in Poland is in majority of analyzed parameters not substantially different from opinions in other member states of EU. However, the medical society should be more active in influencing and changing some negative impressions.

  2. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research

    National Research Council Canada - National Science Library

    Sim, Ida; Tu, Samson W; Carini, Simona; Lehmann, Harold P; Pollock, Brad H; Peleg, Mor; Wittkowski, Knut M

    2014-01-01

    .... The activities of these scientific processes - the science of clinical research - are centered on the study protocol, which is the abstract representation of the scientific design of a clinical study...

  3. Clinical indications for computed tomographic colonography: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline

    NARCIS (Netherlands)

    Spada, Cristiano; Stoker, Jaap; Alarcon, Onofre; Barbaro, Federico; Bellini, Davide; Bretthauer, Michael; de Haan, Margriet C.; Dumonceau, Jean-Marc; Ferlitsch, Monika; Halligan, Steve; Helbren, Emma; Hellstrom, Mikael; Kuipers, Ernst J.; Lefere, Philippe; Mang, Thomas; Neri, Emanuele; Petruzziello, Lucio; Plumb, Andrew; Regge, Daniele; Taylor, Stuart A.; Hassan, Cesare; Laghi, Andrea

    2014-01-01

    This is an official guideline of the European Society of Gastrointestinal Endoscopy (ESGE) and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR). It addresses the clinical indications for the use of computed tomographic colonography (CTC). A targeted literature search was

  4. Statistics in clinical research: Important considerations

    Directory of Open Access Journals (Sweden)

    Howard Barkan

    2015-01-01

    Full Text Available Statistical analysis is one of the foundations of evidence-based clinical practice, a key in conducting new clinical research and in evaluating and applying prior research. In this paper, we review the choice of statistical procedures, analyses of the associations among variables and techniques used when the clinical processes being examined are still in process. We discuss methods for building predictive models in clinical situations, and ways to assess the stability of these models and other quantitative conclusions. Techniques for comparing independent events are distinguished from those used with events in a causal chain or otherwise linked. Attention then turns to study design, to the determination of the sample size needed to make a given comparison, and to statistically negative studies.

  5. Statistics in clinical research: Important considerations

    Science.gov (United States)

    Barkan, Howard

    2015-01-01

    Statistical analysis is one of the foundations of evidence-based clinical practice, a key in conducting new clinical research and in evaluating and applying prior research. In this paper, we review the choice of statistical procedures, analyses of the associations among variables and techniques used when the clinical processes being examined are still in process. We discuss methods for building predictive models in clinical situations, and ways to assess the stability of these models and other quantitative conclusions. Techniques for comparing independent events are distinguished from those used with events in a causal chain or otherwise linked. Attention then turns to study design, to the determination of the sample size needed to make a given comparison, and to statistically negative studies. PMID:25566715

  6. Overview and present status of the European Commission research programme

    CERN Document Server

    O'Sullivan, D

    1999-01-01

    By the early 1990s the European Commission agreed that a comprehensive survey of the radiation environment produced by cosmic rays at aviation altitudes should be undertaken and that an extensive programme of experimental and theoretical studies should be supported. By calling on the resources of scientists in the fields of neutron physics, cosmic ray physics and general dosimetry it was felt that a successful investigation could be undertaken using the techniques and expertise of all concerned. By employing a wide range of detectors on several routes, both on subsonic and supersonic aircraft, a detailed set of measurements was obtained over a five- year period. Many of the measurements were made simultaneously by several instruments on the same flights so that intercomparison of results was possible. Detectors were also deployed on high altitude mountains to facilitate extrapolation of data to lower altitudes for verification of theoretical models. Instruments were calibrated in the CERN-CEC reference field ...

  7. "Ethics and Clinical Research" in Biographical Perspective.

    Science.gov (United States)

    Lederer, Susan E

    2016-01-01

    Henry K. Beecher (1904-1976) played an important role in the development of bioethics. His 1966 article "Ethics and Clinical Research" in the New England Journal of Medicine intensified concern about the welfare of patients participating in clinical research, and his leadership in the 1968 Harvard Ad Hoc Committee on Brain Death redefined the determination of death. Beecher deserves, and even demands, explanation and explication. This essay offers a biographical perspective on the Harvard professor. In addition to his early life and education in both Kansas and Boston, the essay explores how Beecher's experiences in World War II and in the new geopolitical realities of the Cold War shaped his views about the ethical dilemmas of clinical research.

  8. European health research and globalisation: is the public-private balance right?

    Directory of Open Access Journals (Sweden)

    McCarthy Mark

    2011-03-01

    Full Text Available Abstract Background The creation and exchange of knowledge between cultures has benefited world development for many years. The European Union now puts research and innovation at the front of its economic strategy. In the health field, biomedical research, which benefits the pharmaceutical and biotechnology industries, has been well supported, but much less emphasis has been given to public health and health systems research. A similar picture is emerging in European support for globalisation and health Case studies Two case-studies illustrate the links of European support in global health research with industry and biomedicine. The European Commission's directorates for (respectively Health, Development and Research held an international conference in Brussels in June 2010. Two of six thematic sessions related to research: one was solely concerned with drug development and the protection of intellectual property. Two European Union-supported health research projects in India show a similar trend. The Euro-India Research Centre was created to support India's participation in EU research programmes, but almost all of the health research projects have been in biotechnology. New INDIGO, a network led by the French national research agency CNRS, has chosen 'Biotechnology and Health' and funded projects only within three laboratory sciences. Discussion Research for commerce supports only one side of economic development. Innovative technologies can be social as well as physical, and be as likely to benefit society and the economy. Global health research agendas to meet the Millenium goals need to prioritise prevention and service delivery. Public interest can be voiced through civil society organisations, able to support social research and public-health interventions. Money for health research comes from public budgets, or indirectly through healthcare costs. European 'Science in Society' programme contrasts research for 'economy', using technical

  9. European health research and globalisation: is the public-private balance right?

    Science.gov (United States)

    McCarthy, Mark

    2011-03-22

    The creation and exchange of knowledge between cultures has benefited world development for many years. The European Union now puts research and innovation at the front of its economic strategy. In the health field, biomedical research, which benefits the pharmaceutical and biotechnology industries, has been well supported, but much less emphasis has been given to public health and health systems research. A similar picture is emerging in European support for globalisation and health Two case-studies illustrate the links of European support in global health research with industry and biomedicine. The European Commission's directorates for (respectively) Health, Development and Research held an international conference in Brussels in June 2010. Two of six thematic sessions related to research: one was solely concerned with drug development and the protection of intellectual property. Two European Union-supported health research projects in India show a similar trend. The Euro-India Research Centre was created to support India's participation in EU research programmes, but almost all of the health research projects have been in biotechnology. New INDIGO, a network led by the French national research agency CNRS, has chosen 'Biotechnology and Health' and funded projects only within three laboratory sciences. Research for commerce supports only one side of economic development. Innovative technologies can be social as well as physical, and be as likely to benefit society and the economy. Global health research agendas to meet the Millenium goals need to prioritise prevention and service delivery. Public interest can be voiced through civil society organisations, able to support social research and public-health interventions. Money for health research comes from public budgets, or indirectly through healthcare costs. European 'Science in Society' programme contrasts research for 'economy', using technical solutions, commercialisation and a passive consumer voice for

  10. The use of empirical research in bioethics: a survey of researchers in twelve European countries.

    Science.gov (United States)

    Wangmo, Tenzin; Provoost, Veerle

    2017-12-22

    The use of empirical research methods in bioethics has been increasing in the last decades. It has resulted in discussions about the 'empirical turn of bioethics' and raised questions related to the value of empirical work for this field, methodological questions about its quality and rigor, and how this integration of the normative and the empirical can be achieved. The aim of this paper is to describe the attitudes of bioethics researchers in this field towards the use of empirical research, and examine their actual conduct: whether they use empirical research methods (and if so, what methods), and whether (and how) they have made attempts at integrating the empirical and the normative. An anonymous online survey was conducted to reach scholars working in bioethics/biomedical ethics/ethics institutes or centers in 12 European countries. A total of 225 bioethics researchers participated in the study. Of those, 200 questionnaires were fully completed, representing a response rate of 42.6%. The results were analysed using descriptive statistics. Most respondents (n = 175; 87.5%) indicated that they use or have used empirical methods in their work. A similar proportion of respondents (61.0% and 59.0%) reported having had at least some training in qualitative or quantitative methods, respectively. Among the 'empirical researchers', more than a fifth (22.9%) had not received any methodological training. It appears that only 6% or less of the 'empirical researchers' considered themselves experts in the methods (qualitative or quantitative) that they have used. Only 35% of the scholars who have used empirical methods reported having integrated empirical data with normative analysis, whereas for their current projects, 59.8% plan to do so. There is a need to evaluate the current educational programs in bioethics and to implement rigorous training in empirical research methods to ensure that 'empirical researchers' have the necessary skills to conduct their empirical

  11. Management of obesity in adults: European clinical practice guidelines.

    Science.gov (United States)

    Tsigos, Constantine; Hainer, Vojtech; Basdevant, Arnaud; Finer, Nick; Fried, Martin; Mathus-Vliegen, Elisabeth; Micic, Dragan; Maislos, Maximo; Roman, Gabriela; Schutz, Yves; Toplak, Hermann; Zahorska-Markiewicz, Barbara

    2008-01-01

    The development of consensus guidelines for obesity is complex. It involves recommending both treatment interventions and interventions related to screening and prevention. With so many publications and claims, and with the awareness that success for the individual is short-lived, many find it difficult to know what action is appropriate in the management of obesity. Furthermore, the significant variation in existing service provision both within countries as well as across the regions of Europe makes a standardised approach, even if evidence-based, difficult to implement. In formulating these guidelines, we have attempted to use an evidence-based approach while allowing flexibility for the practicing clinician in domains where evidence is currently lacking and ensuring that in treatment there is recognition of clinical judgment and of regional diversity as well as the necessity of an agreed approach by the individual and family. We conclude that i) physicians have a responsibility to recognise obesity as a disease and help obese patients with appropriate prevention and treatment, ii) treatment should be based on good clinical care and evidence-based interventions and iii) obesity treatment should focus on realistic goals and lifelong management. Copyright 2008 S. Karger AG, Basel.

  12. Challenges in conducting clinical nutrition research.

    Science.gov (United States)

    Weaver, Connie M; Miller, Joshua W

    2017-07-01

    Clinical nutrition research has played a pivotal role in establishing causality between diet or nutrient intake and health outcome measures and in the determination of dietary requirements and levels of supplementation to achieve specific outcomes. Because the studies are performed with humans, clinical nutrition research can be readily translated into public health messages. However, there are many challenges and considerations unique to the field, such as the baseline nutritional status of study participants, defining appropriate control groups, effective blinding of participants and investigators, the evolving ethics of randomized control trials, and a tension in a priori decisions regarding inclusion of nutritionally vulnerable participants versus representative samples of general populations. Regulatory approvals that place increasing burdens on the ability of investigators to carry out and complete research protocols have grown dramatically in recent years. There is much room for improved efficiency in the approval and reporting processes aimed at protecting volunteers and providing transparency to the public. Decreased redundancy would have a direct benefit to clinical nutrition research and investigators. Despite these challenges, the information to be gained and the rewards of clinical nutrition research remain high. © The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  13. Risky Experiences for Children Online: Charting European Research on Children and the Internet

    Science.gov (United States)

    Livingstone, Sonia; Haddon, Leslie

    2008-01-01

    Children's online experience, especially the risks to which they might be exposed, is an increasingly important policy and research concern. This article reports an analysis of the amount, nature and range of empirical research concerning children's online experiences across 18 European countries. Research teams in each country have collaborated,…

  14. The methodological quality of clinical guidelines of the European Society of Human Reproduction and Embryology (ESHRE).

    Science.gov (United States)

    Nelen, W L D M; van der Pluijm, R W; Hermens, R P M G; Bergh, C; de Sutter, P; Nygren, K G; Wetzels, A M M; Grol, R P T M; Kremer, J A M

    2008-08-01

    Clinical practice guidelines bridge the gap between the evidence from literature and clinical practice, and they may provide guidance in ethical, legal and societal dilemmas. To explore the potentials for future international guideline development within the field of human reproduction and embryology, we assessed the quality of existing guidelines produced by the European Society of Human Reproduction and Embryology (ESHRE). We systematically searched for the ESHRE guidelines produced after 1996 in electronic databases and on the Internet. Subsequently, we assessed the methodological quality of these guidelines using the validated Appraisal of Guidelines for Research and Evaluation (AGREE) Instrument. The overall methodological quality of most of the 11 selected ESHRE guidelines was poor. Most of the guidelines scored development', 'applicability' and 'editorial independence'. Only one guideline was rated 'strongly recommended'. The methodological quality of the guidelines produced under the auspices of ESHRE can be improved. We suggest a systematic, up-to-date methodology, investment in guideline development specialists, systematic quality control and the incorporation of indicator development. Furthermore, attention should be paid to the document nomenclature, and an ESHRE guidelines' summary on a special part of the ESHRE website would be a good initiative.

  15. 59th Clinical Research Division Research Day Briefing

    Science.gov (United States)

    2016-10-27

    College of Lab Animal Medicine; Certified by American College of Veterinary Pathology 1 - PhD, Physiology/Biochem - Clinical Research Admin...Budg~ Research Support Pathology McrobioloQ’J Training Supply Hematology Toxicology Chemistry M>lecular 4 22 Nov 11 CRD Staff Expertise D r I r...Laboratory Services Branch Dr. Thomas Gibbons - 292-7363 Thomas.gibbons@us.af.mil Pathology Section Support L TC Michele Thompson - 292-6589

  16. Towards Horizon 2020: challenges and advances for clinical mental health research - outcome of an expert survey.

    Science.gov (United States)

    van der Feltz-Cornelis, Christina M; van Os, Jim; Knappe, Susanne; Schumann, Gunter; Vieta, Eduard; Wittchen, Hans-Ulrich; Lewis, Shôn W; Elfeddali, Iman; Wahlbeck, Kristian; Linszen, Donald; Obradors-Tarragó, Carla; Haro, Josep Maria

    2014-01-01

    The size and increasing burden of disease due to mental disorders in Europe poses substantial challenges to its population and to the health policy of the European Union. This warrants a specific research agenda concerning clinical mental health research as one of the cornerstones of sustainable mental health research and health policy in Europe. The aim of this research was to identify the top priorities needed to address the main challenges in clinical research for mental disorders. The research was conducted as an expert survey and expert panel discussion during a scientific workshop. Eighty-nine experts in clinical research and representing most European countries participated in this survey. Identified top priorities were the need for new intervention studies, understanding the diagnostic and therapeutic implications of mechanisms of disease, and research in the field of somatic-psychiatric comorbidity. The "subjectivity gap" between basic neuroscience research and clinical reality for patients with mental disorders is considered the main challenge in psychiatric research, suggesting that a shift in research paradigms is required. Innovations in clinical mental health research should bridge the gap between mechanisms underlying novel therapeutic interventions and the patient experience of mental disorder and, if present, somatic comorbidity. Clinical mental health research is relatively underfunded and should receive specific attention in Horizon 2020 funding programs.

  17. Budgeting, funding, and managing clinical research projects.

    Science.gov (United States)

    Hatfield, Elizabeth; Dicks, Elizabeth; Parfrey, Patrick

    2009-01-01

    Large, integrated multidisciplinary teams have become recognized as an efficient means by which to drive innovation and discovery in clinical research. This chapter describes how to budget and fund these large studies and effectively manage the large, often dispersed teams involved. Sources of funding are identified; budget development, justification, reporting, financial governance, and accountability are described; in addition to the creation and management of the multidisciplinary team that will implement the research plan.

  18. Clinical research directions in pediatric cardiology.

    Science.gov (United States)

    Lipshultz, Steven E; Wilkinson, James D; Messiah, Sarah E; Miller, Tracie L

    2009-10-01

    Clinical research in pediatric cardiology is under-appreciated and under-funded, yet it has enormous implications for cardiovascular health and healthcare over the entire life-course. Renewed interest in federally funded clinical research makes it timely to propose a comprehensive research agenda that, with its associated rationale, will attract public funds for research into child cardiovascular health and disease. We propose here a comprehensive pediatric cardiology research agenda consisting of 22 topics and associated research questions. We describe the following five topics in more detail: the need for life-course studies of pediatric cardiac disease and epigenetic factors for later onset of cardiovascular effects; the need to study cardiometabolic disease risk in children; recent pediatric cardiology clinical trials and observational studies; the need to explore the role of physical activity in preventing and treating pediatric cardiology patients; and the need to develop and implement evidence-based interventions to manage pediatric cardiovascular problems. If the field of pediatric cardiology can adopt a comprehensive research agenda that identifies the most-needed studies, then research could be better coordinated, long-term and collaborative studies would be more readily organized and funded, and the overall financial and scientific efficiency of research in pediatric cardiology would be improved. Targeted research efforts are more likely to realize potential breakthroughs in areas such as genetic and epigenetic screening, biomarkers, cardioprotective strategies, life-course studies, long-term monitoring technologies, environmental influences on disease, evidence-based practice guidelines, and more rapid and safer development of drugs.

  19. Clinical Psychology and Research: epistemological notes

    Directory of Open Access Journals (Sweden)

    Emanuela Coppola

    2013-05-01

    Full Text Available The paper proposes a reflection on the relationship between clinical psychology and research, highlighting the constant epistemological crossing the two practices, empirical and professional. The paper warns against the pitfalls of reductionism that, in both cases, may impact the effectiveness of therapeutic results. In fact, both in clinical practice and is in psychological research, the mere application of techniques contradicts the specificity of the object of study (the mind which, rather, requires the constant attention to a complexity of variables and contextual elements essential for the understanding the psychic. Qualitative research has been a prolific space for dialogue and joint trials between research and clinical practice that has rehabilitated scientific dignity of affective and subjective for a long time confined to the ephemeral world of poetry and literature. It must therefore be a further extension of the convergence not only of qualitative and quantitative methods but also of training modules for researchers and practitioners are able to stimulate, in daily practice, confidence in the utility of scientific monitoring and detection of inter-subjective variables in research devices.

  20. Action research methodology in clinical pharmacy

    DEFF Research Database (Denmark)

    Nørgaard, Lotte Stig; Sørensen, Ellen Westh

    2016-01-01

    Introduction The focus in clinical pharmacy practice is and has for the last 30-35 years been on changing the role of pharmacy staff into service orientation and patient counselling. One way of doing this is by involving staff in change process and as a researcher to take part in the change process...... by establishing partnerships with staff. On the background of the authors' widespread action research (AR)-based experiences, recommendations and comments for how to conduct an AR-study is described, and one of their AR-based studies illustrate the methodology and the research methods used. Methodology AR...... is defined as an approach to research which is based on a problem-solving relationship between researchers and clients, which aims at both solving a problem and at collaboratively generating new knowledge. Research questions relevant in AR-studies are: what was the working process in this change oriented...

  1. Blockchain technology for improving clinical research quality.

    Science.gov (United States)

    Benchoufi, Mehdi; Ravaud, Philippe

    2017-07-19

    Reproducibility, data sharing, personal data privacy concerns and patient enrolment in clinical trials are huge medical challenges for contemporary clinical research. A new technology, Blockchain, may be a key to addressing these challenges and should draw the attention of the whole clinical research community.Blockchain brings the Internet to its definitive decentralisation goal. The core principle of Blockchain is that any service relying on trusted third parties can be built in a transparent, decentralised, secure "trustless" manner at the top of the Blockchain (in fact, there is trust, but it is hardcoded in the Blockchain protocol via a complex cryptographic algorithm). Therefore, users have a high degree of control over and autonomy and trust of the data and its integrity. Blockchain allows for reaching a substantial level of historicity and inviolability of data for the whole document flow in a clinical trial. Hence, it ensures traceability, prevents a posteriori reconstruction and allows for securely automating the clinical trial through what are called Smart Contracts. At the same time, the technology ensures fine-grained control of the data, its security and its shareable parameters, for a single patient or group of patients or clinical trial stakeholders.In this commentary article, we explore the core functionalities of Blockchain applied to clinical trials and we illustrate concretely its general principle in the context of consent to a trial protocol. Trying to figure out the potential impact of Blockchain implementations in the setting of clinical trials will shed new light on how modern clinical trial methods could evolve and benefit from Blockchain technologies in order to tackle the aforementioned challenges.

  2. Towards a European strategy for medicines research (2014-2020): The EUFEPS position paper on Horizon 2020.

    Science.gov (United States)

    Gaspar, Rogério; Aksu, Buket; Cuine, Alain; Danhof, Meindert; Takac, Milena Jadrijevic-Mladar; Linden, Hans H; Link, Andreas; Muchitsch, Eva-Maria; Wilson, Clive G; Ohrngren, Per; Dencker, Lennart

    2012-12-18

    As to the alignment of "Horizon 2020", ir is a more integrated approach to European science policy than expressed in the proposals previously drafted, and specifically considers: (i) promoting excellence in Science, (ii) establishing a sound industrial leadership and (iii) expressing an ambition to address current and future societal challenges. In this respect, the quest for a knowledge-based economy in Europe should result in proposals for industrial and employment policies that will consolidate the major European advantages in the biomedical, healthcare and pharmaceutical sectors. Horizon 2020 also provides the possibility of adopting a more flexible and simplified management route to drive European research through innovation, research and development. What should be additionally considered? Unmet medical needs, under pressure from demographic changes, await the generation of new medicines and health technologies which will evolve into a driver for a unified European policy. We believe that this should be focused on harnessing pharmaceutical knowledge for clinical use, as part of a response to accommodate patient needs and economic growth based on a robust, scientific approach. The bolder ambition for European research is to unlock key bottlenecks currently undermining European competitiveness. The historical lack of an appropriate business/innovation environment with reduced access to adequate risk finance instruments has severed the path for economic growth and industrial development. These issues are of critical importance and a solution is urgently needed to foster translation from the university to the healthcare sector through the generation and support of start-ups, spin-offs, university-industry consortia, and other platforms, which support translational research. The ultimate goal is implementation of holistic programmes: the 'bench to bedside' paradigm of medicines and other healthcare products. The European Research Council supports the basic

  3. Evidence-based clinical management and utilization of new technology in European neurosurgery.

    Science.gov (United States)

    Weber, Clemens; Jakola, Asgeir S; Gulati, Sasha; Nygaard, Oystein P; Solheim, Ole

    2013-04-01

    Evidence-based medicine (EBM) has become one of the pillars of modern patient care. However, neurosurgery has always been an experience-based and technology-driven discipline, and it remains unknown to which extent European neurosurgeons follow high-level evidence-based recommendations. We conducted a Web-based survey with a 15-item questionnaire about evidence-based clinical management and utilization of new technology among European neurosurgeons. Two different sum scores were calculated from the questions concerning clinical practice; evidence-based treatment score and new technology score. A high evidence-based treatment score means that more clinical conditions (i.e., study questions) were managed in compliance with the available highest levels of evidence from published clinical trials. A high new technology score reflects the use of a high number of modern tools in neurosurgical practice. A total of 239 neurosurgeons from 30 different European countries answered the questionnaire. There were large variations among European neurosurgeons in providing evidence-based care and in utilization of various modern tools. There were significant regional differences in evidence-based treatment scores and modern technology scores with higher scores in northern and western Europe. High-volume institutions were not associated with better evidence-based treatment scores, but had significantly higher new technology scores. There were significantly higher new technology scores at university hospitals and a trend towards higher evidence-based treatment scores compared to other hospitals. Clinical management in neurosurgery does not always comply with the best available evidence and there are large regional differences in clinical management and in utilization of various modern tools. The position of evidence-based medicine in European neurosurgery seems weak and this may be a threat to the quality of care.

  4. Future development, innovation and promotion of European unique food: an interdisciplinary research framework perspective.

    Science.gov (United States)

    Byrne, Derek V; Waehrens, Sandra S; O'Sullivan, Maurice G

    2013-11-01

    Unique food products constitute a very important element of European food business, culture, identity and heritage. Understanding the uniqueness of food in Europe from a research-based interdisciplinary perspective will be a critical factor in promoting the competitiveness of artisanal food industries going forward both locally and internationally. Success will support the competitiveness of the European food industry, in particular, small and medium enterprises, by enabling substantial product differentiation potential for producers and providing ample variety in food choice for the consumer. In addition, it will contribute to promotion of sustainable agriculture and development of rural areas, protecting them from depopulation. In order to meet the demands of a developing fundamental shift in European Union agricultural focus to greener, sustainable farming practices and wider rural development and to ensure success for local small-scale producers, this paper discusses the future direction of research in the field of unique European foods. The paper presents a perspective which promotes optimisation and innovation in unique food products in Europe through the integration of advanced knowledge and technologies. A framework is presented covering location, identity, perception and well-being as research areas needing synergy to bridge the research knowledge deficit in determination and specification of food identity in the European Union. The ultimate aim being promotion of sustainable agriculture and rural development, particularly in territories across the European Union where unique food is strategically and scientifically under-defined. © 2013 Society of Chemical Industry.

  5. Research: Clinical undergraduate medical student training at ...

    African Journals Online (AJOL)

    To profile the clinicians at Kimberley Hospital Complex in terms of their knowledge of, skills in and perspectives on the added responsibility of clinical undergraduate medical student training prior to the launch of the proposed undergraduate student rotations. Methods. The study followed a qualitative research design using ...

  6. TOPIC: CLINICAL NURSING RESEARCH: A TOOL FOR ...

    African Journals Online (AJOL)

    DR. MRS. AKPABIO

    other professional staff in the health arena for the purpose of improving patient care and health outcomes. There could therefore, not exist any professional development in Nursing without clinical nursing research. Professional development involves professional standards, increased accountabilities, effective and efficient ...

  7. Proteogenomics | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Proteogenomics, or the integration of proteomics with genomics and transcriptomics, is an emerging approach that promises to advance basic, translational and clinical research.  By combining genomic and proteomic information, leading scientists are gaining new insights due to a more complete and unified understanding of complex biological processes.

  8. Vulnerability of pregnant women in clinical research

    NARCIS (Netherlands)

    van der Zande, Indira S. E.; van der Graaf, Rieke; Oudijk, Martijn A.; van Delden, Johannes J. M.

    2017-01-01

    Notwithstanding the need to produce evidence-based knowledge on medications for pregnant women, they remain underrepresented in clinical research. Sometimes they are excluded because of their supposed vulnerability, but there are no universally accepted criteria for considering pregnant women as

  9. The EU-AIMS Longitudinal European Autism Project (LEAP) : Clinical characterisation

    NARCIS (Netherlands)

    Charman, Tony; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, Caroline; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara|info:eu-repo/dai/nl/413586561; Banaschewski, Tobias; Baron-Cohen, Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Yvette; Chakrabarti, Bhismadev; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, Guillaume; Durston, Sarah|info:eu-repo/dai/nl/243083912; Ecker, Christine; Faulkner, Jessica; Frouin, Vincent; Garcés, Pilar; Ham, Lindsay; Hayward, Hannah; Hipp, Joerg; Holt, Rosemary J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J.H.; Kundu, Prantik; Lai, Meng Chuan; D'Ardhuy, Xavier Liogier; Lombardo, Michael V.; Lythgoe, David J; Mandl, René|info:eu-repo/dai/nl/304814172; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob|info:eu-repo/dai/nl/217177409; Pandina, Gahan; Persico, Antonio M.; Ruggeri, Barbara; Ruigrok, Amber N V; Sabet, Jessica; Sacco, Roberto; Cáceres, Antonia San Jóse; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams, Steve C.R.; Zwiers, Marcel P.; Spooren, Will; Murphy, Declan G M; Buitelaar, Jan K.

    2017-01-01

    Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ

  10. European Bioinformatics Institute: Research Infrastructure needed for Life Science

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    The life science community is an ever increasing source of data from increasing diverse range of instruments and sources. EMBL-EBI has a remit to store and exploit this data, collected and made available openly across the world, for the benefit of the whole research community. The research infrastructure needed to support the big data analysis around this mission encompasses high performance networks, high-throughput computing, and a range of cloud and storage solutions - and will be described in the presentation.

  11. The strategic research agenda on EMC in the next (7th) European research framework program 2007-2013

    NARCIS (Netherlands)

    Leferink, Frank Bernardus Johannes

    2006-01-01

    The European Commission has published the research policy and the proposal for the next (7th) Framework Programme [1]. It is stated that, to be a genuinely competitive, knowledge-based economy, Europe must become better at producing knowledge through research, at diffusing it through education and

  12. Enabling European Archaeological Research: The ARIADNE E-Infrastructure

    Directory of Open Access Journals (Sweden)

    Nicola Aloia

    2017-03-01

    Full Text Available Research e-infrastructures, digital archives and data services have become important pillars of scientific enterprise that in recent decades has become ever more collaborative, distributed and data-intensive. The archaeological research community has been an early adopter of digital tools for data acquisition, organisation, analysis and presentation of research results of individual projects. However, the provision of e-infrastructure and services for data sharing, discovery, access and re-use has lagged behind. This situation is being addressed by ARIADNE: the Advanced Research Infrastructure for Archaeological Dataset Networking in Europe. This EU-funded network has developed an e-infrastructure that enables data providers to register and provide access to their resources (datasets, collections through the ARIADNE data portal, facilitating discovery, access and other services across the integrated resources. This article describes the current landscape of data repositories and services for archaeologists in Europe, and the issues that make interoperability between them difficult to realise. The results of the ARIADNE surveys on users' expectations and requirements are also presented. The main section of the article describes the architecture of the e-infrastructure, core services (data registration, discovery and access and various other extant or experimental services. The on-going evaluation of the data integration and services is also discussed. Finally, the article summarises lessons learned, and outlines the prospects for the wider engagement of the archaeological research community in sharing data through ARIADNE.

  13. A research mentor training curriculum for clinical and translational researchers.

    Science.gov (United States)

    Pfund, Christine; House, Stephanie; Spencer, Kimberly; Asquith, Pamela; Carney, Paula; Masters, Kristyn S; McGee, Richard; Shanedling, Janet; Vecchiarelli, Stephanie; Fleming, Michael

    2013-02-01

    To design and evaluate a research mentor training curriculum for clinical and translational researchers. The resulting 8-hour curriculum was implemented as part of a national mentor training trial. The mentor training curriculum was implemented with 144 mentors at 16 academic institutions. Facilitators of the curriculum participated in a train-the-trainer workshop to ensure uniform delivery. The data used for this report were collected from participants during the training sessions through reflective writing, and following the last training session via confidential survey with a 94% response rate. A total of 88% of respondents reported high levels of satisfaction with the training experience, and 90% noted they would recommend the training to a colleague. Participants also reported significant learning gains across six mentoring competencies as well as specific impacts of the training on their mentoring practice. The data suggest the described research mentor training curriculum is an effective means of engaging research mentors to reflect upon and improve their research mentoring practices. The training resulted in high satisfaction, self-reported skill gains as well as behavioral changes of clinical and translational research mentors. Given success across 16 diverse sites, this training may serve as a national model. © 2012 Wiley Periodicals, Inc.

  14. Research Priority of Clinical Linguistics in Iran

    Directory of Open Access Journals (Sweden)

    Ahadi

    2016-04-01

    Full Text Available Background Study in clinical linguistics can reflect and requirements of this area, and can contribute to effective and useful changes in this area. Objectives Since there have been a few studies in the field of clinical linguistics in Iran, this research can pave the way to find research priorities of clinical linguistics in our country. Materials and Methods Studies related to linguistics and speech therapy were collected and studied since their appearance in the literature up to 2012 to determine the number of studies performed on clinical linguistics and its evolutionary trend. Results The most and least numbers of studies conducted by speech therapists on linguistics are related to phonetics/phonology (37% and pragmatics (14%, respectively. In linguistics, there are a few studies on disorders (0.02%, which are mostly in the domain of aphasia (40%; therefore, other disorders should be investigated too. Conclusions The number of linguistic studies on language and speech therapy is more than that of the studies in which clinical data are used to study the theories and hypotheses. Therefore, it is necessary to consider this area seriously and guide the studies toward the theories proposed in the related disorders. Thus, attention must be paid to pragmatic and semantic domains of the disorder which are considered less.

  15. Mass Movement Inventories for Climate Research in the European Alps

    Science.gov (United States)

    Wood, J.; Harrison, S.; Reinhardt, L.

    2013-12-01

    Climate influences landscape evolution through physical processes which affect the form of a landscape through myriad small- to large-scale mechanisms. These can manifest through mass movements and rockfalls which present an important geomorphological hazard in Alpine regions; threatening life, infrastructure and property. Modelling has shown that the response of mass movements to temperature and precipitation triggers vary over a number of timescales. Heavy rainfall events on shorter timescales (ranging from minutes to days) can exceed critical ground- and pore-water levels resulting in mass movement initiation (Iverson, 2000), whereas longer precipitation trends act as precursors to larger events. Extreme temperatures, such as the summer of 2003 which was characterised by 'exceptional rockfall' (Gruber et al., 2004, p. 1) and extreme permafrost thaw in the European Alps, illustrate how short-term extreme increases in temperature can cause widespread destabilisation (Chemanda et al., 2005). Freeze-thaw action on seasonal timescales can greatly exaggerate mechanical weathering (Abele, 1997; Chigira, 2002), whilst increases in temperature (resulting from sub-annual to longer term changes) reduce both cohesive and tensile strength within slopes (Chemanda et al., 2005) leading to rock degradation. Differences in topography and geology in the region mean that the impacts of climate change are likely to vary in space and time and analysis of these is therefore required to understand the spatial patterns of mass movements through time. Here we present the development of a new regional mass movement inventory (RI) for the French and Swiss Alps. Our aim is to provide a substantial spatial picture of rockfalls and landsliding in the region through time. We discuss methods by which to improve existing inventories including the use of scaling relationships (Larsen et al., 2010) to calculate area based on a given volume for similar types of mass movement. We show that based on

  16. Joining Forces: European Periodical Studies as a New Research Field

    OpenAIRE

    Van Remoortel, Marianne; Ewins, Kristin; Koffeman, Maaike; Philpotts, Matthew

    2016-01-01

    In recent decades, periodical studies have burgeoned into a vibrant field of research. Increasing numbers of scholars working in disciplines across the humanities — literary studies, history, art history, gender studies, media studies, legal history, to name a few — are exploring the press as a key site for cultural production, public debate and the dissemination of knowledge. [...

  17. [Promotion of basic research in the European Union: the European research council (ERC) and the initiative for science in Europe (ISE )].

    Science.gov (United States)

    Zaragoza, Federico Mayor

    2007-01-01

    Europe has today a function of intellectual guidance and watch tower that will be unable to accomplish if remains far of the forefront in scientific research and application of knowledge The "delocalization of talents" towards the west is much worst than that of production towards the east. From January 1st 2007, the ERC, with an annual budget of 1.5 billion Euros, represents an important step to improve the situation. The ISE, representing the European scientific community, will further enhance it.

  18. Towards the "Fifth Freedom": Increasing the Mobility of Researchers in the European Union

    Science.gov (United States)

    Marimon, Ramon; Lietaert, Matthieu; Grigolo, Michele

    2009-01-01

    Many researchers trained in Europe leave to work abroad, namely in the USA. This brain-drain phenomenon is the result of a lack of openness and competition in European academic systems. Some aspects relating to the mobility of academic careers could make a difference in attracting--and maintaining--researchers, aside to serious structural reform.…

  19. From Research to Development on Virtual Language, Content and Intercultural Learning across European Schools

    Science.gov (United States)

    Ramírez-Verdugo, Maria Dolores

    2012-01-01

    This paper presents an overview of the research conducted within a funded Comenius project which aims at developing a virtual European CLIL Resource Centre for Web 2.0 Education. E-CLIL focuses on Content and Language Integrated Learning (CLIL), creativity and multiculturalism through digital resources. In this sense, our prior research on CLIL…

  20. Civil society and public health research in the European Union new member states.

    Science.gov (United States)

    McCarthy, Mark; Knabe, Agnese

    2012-05-01

    Civil society organisations (CSOs) are not-for-profit organisations working for the public interest with concerns complementary to public health. We investigated the contribution of CSOs in public health research. Within a European project STEPS (Strengthening Engagement with Public Health Research), CSOs with interests in health were identified in the new member states of the European Union (Estonia, Latvia, Lithuania, Poland, Hungary, Slovakia, Czech Republic, Slovenia, Romania, Bulgaria, Malta, and Cyprus) and workshops organised, held in their own languages. The reports of the workshops were translated into English and drawn together through a framework analysis. CSOs can contribute in all stages of the research cycle, through championship, priority-setting, capacity building and generation of resources, sharing and application of the research results, and dissemination across their network of contacts. There have been successful CSO-researcher collaborations in public health fields. Funding is important, and ministries of health and public institutions should interact more with CSOs. Barriers include attitudes, technical understanding across public health fields. There is little European empirical literature linking health CSOs and research: our results indicate benefits and further opportunities. In contrast to biomedicine's link with industry, public health research can align with civil society in not-for-profit research. CSOs are important for European integration, and their contribution should be better recognised at international level.

  1. EERA: A Participant or an Agent in European Research Policy? A Governance Perspective

    Science.gov (United States)

    Moos, Lejf; Wubbels, Theo

    2014-01-01

    In this article, the authors begin to frame a discussion of the educational research space that the European Educational Research Association (EERA) has been given and aims to take. The educational space is not merely a geographical phenomenon, but rather refers to the networks, flows and scapes that form the foundation for the construction of…

  2. EERA: A participant or an agent in European research policy? A governance perspective

    NARCIS (Netherlands)

    Moos, L.; Wubbels, Theo

    2014-01-01

    In this article, the authors begin to frame a discussion of the educational research space that the European Educational Research Association (EERA) has been given and aims to take. The educational space is not merely a geographical phenomenon, but rather refers to the networks, flows and scapes

  3. The Common European Framework of Reference (CEFR) in Canada: A Research Agenda

    Science.gov (United States)

    Arnott, Stephanie; Brogden, Lace Marie; Faez, Farahnaz; Péguret, Muriel; Piccardo, Enrica; Rehner, Katherine; Taylor, Shelley K.; Wernicke, Meike

    2017-01-01

    This article proposes a research agenda for future inquiry into the use of the Common European Framework of Reference (CEFR) in the plurilingual Canadian context. Drawing on data collected from a research forum hosted by the Canadian Association of Second Language Teachers in 2014, as well as a detailed analysis of Canadian empirical studies and…

  4. Paying Clinical Research Participants: One Institution's Research Ethics Committees' Perspective.

    Science.gov (United States)

    Ripley, Elizabeth B D; Macrina, Frank L; Markowitz, Monika

    2006-12-01

    REGULATORY GUIDELINES LEAVE determination of coercion and undue influence of research participants open to interpretation. A web-based survey was conducted of the research ethics committees members at Virginia Commonwealth University (VCU) to evaluate their perspectives on paying participants in clinical research via general questions, as well as 8 short cases involving hypertension placebo-controlled trials, a pilot exercise study, a survey of substance abusers, a healthy-volunteer pharmacokinetic study, a twin study involving DNA samples, and an asthma medication study in children. Research ethics committee members were asked to state what payment they would consider appropriate for a given type of protocol. The results suggest that risk, time required, reimbursement for expenses, and inconvenience were important in determining appropriate payment, while income and funding source were not. The case studies revealed wide variation in recommended payments both within type of study and between studies.

  5. European conference on advances in flood research. Vol. 1. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Bronstert, A.; Bismuth, C.; Menzel, L. [eds.

    2000-11-01

    Following concern expressed by several Member States in the 1990's, the EC directorate General of Research and Development (DG XII) has initiated and/or funded a variety of activities in order to improve the scientific basis and to intensify knowledge transfer into practice concerning flood forecasting, risk mitigation, and the impact analysis of environmental change effects. After more then half a decade of research in this field, this conference is aimed to present the results achieved and to highlight the scientific advances. Besides the presentations of the EUROTAS-project results, the contributions are grouped into the following sub-sessions: impact of land use and climate on flooding, flood management and assessment of flood risk, catchment modelling and management systems, and impact of river engineering on flooding conditions. (orig.)

  6. European conference on advances in flood research. Vol. 2. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Bronstert, A.; Bismuth, C.; Menzel, L. [eds.

    2000-11-01

    Following concern expressed by several Member States in the 1990's, the EC directorate General of Research and Development (DG XII) has initiated and/or funded a variety of activities in order to improve the scientific basis and to intensify knowledge transfer into practice concerning flood forecasting, risk mitigation, and the impact analysis of environmental change effects. After more then half a decade of research in this field, this conference is aimed to present the results achieved and to highlight the scientific advances. Besides the presentations of the EUROTAS-project results, the contributions are grouped into the following sub-sessions: impact of land use and climate on flooding, flood management and assessment of flood risk, catchment modelling and management systems, and impact of river engineering on flooding conditions. (orig.)

  7. Research fields, challenges and opportunities in European oilseed crops breeding

    Directory of Open Access Journals (Sweden)

    Vincourt Patrick

    2014-11-01

    Full Text Available Due to the geographical specialization in oilseed world production, Europe has a major role to play in winter oilseed rape and sunflower breeding. Mainly based on the most recen t results, this review aims to identify the main research and breeding targets for these two crops, as seen through publications, with an attempt to suggest what are opportunities and challenges in these research fields. Growing a healthy and yielding crop remains the key driver for agronomic production. However sustainability and environmental profiles of the cultivar are now entering the field of play: The sustainability concern invested the field of resistance to diseases. Nitrogen use efficiency became an important target for Brassica napus, and crop resilience toward drought stresses is the way chosen in Helianthus annuus breeding for yield improvement. Significant advances are underway for quality traits, but the uncertainty on nutritional and industrial demand may explain why the product diversification remains low.

  8. Relationship coach-athlete : outstanding trends in european research

    OpenAIRE

    Serpa, Sidónio Olivério da Costa

    1999-01-01

    Sports performance, although depending on individuais'characteristics,also reflects the way coach-athlete relationship takes place in the sport preparation process. Social psychology of sport has developed the study of the interaction processes between those actors,aiming at having a better understanding of them and at having a conceptual basis to propose the management of that relationship in order to make it more productive in terms of social and sport dynamics. International research...

  9. European Bulletin of Himalayan Research (EBHR) Volume 24, Spring 2003

    OpenAIRE

    South Asia Institute, Heidelberg University, Germany; (CNRS) Centre National de la Recherche Scientifique, France; (SOAS) School of Oriental and African Studies, UK

    2003-01-01

    Remarks on Revolutionary Songs and Iconography by Anne de Sales; The Social Context of Nature Conservation in Nepal by Michael Kollmair, Ulrike Muller-Boker and Reto Soliva; Dhol Sagar: Aspects of Drum Knowledge amongst Musicians in Garhwal, North India by Andrew Alter; Conference Report on the Agenda of Transformation: Inclusion in Nepali Democracy, Kathmandu, 24-26 April 2003 by Sara Shneiderman and Mark Turin; Report on the Conference Nepal - Current State of Research and Perspectives held...

  10. European regulations for the introduction of novel radiopharmaceuticals in the clinical setting.

    Science.gov (United States)

    Decristoforo, Clemens; Penuelas, Ivan; Patt, Marianne; Todde, Sergio

    2017-06-01

    The development of novel radiopharmaceuticals is very rapid and highly innovative both for diagnostic and therapeutic applications. The translation into the clinic, however, is hampered by the high regulatory demands in Europe. This article describes the main rules, guidelines and guidance documents in the European Union in relation to the pharmaceutical regulatory framework. Until today a great number of radiopharmaceuticals are introduced clinically using specific national pathways outside the clinical trial regulation and examples are provided. In this context, the European Pharmacopoeia with a legal status plays an important role in defining quality standards. For clinical trials the application system and regulatory framework in Europe is currently considerably changing. Whereas the current clinical trial directive requires a lengthy and complicated national application process, the new regulation 536/2014 will introduce a streamlined and unified European application process. This new regulation also takes into account the specific properties of radioactive investigational medicinal products and has introduced exceptions for good manufacturing practices (GMP) and labelling for radiopharmaceuticals. Besides the main regulatory texts, several guidelines have been published, e.g. related to toxicity testing or first in man studies. In relation to radiopharmaceuticals professional organization, in particular the EANM, have published a number of documents in relation to GMP, documentation and toxicity studies, that support professionals in the application process. All these documents are summarized and discussed.

  11. European Union - Space of Regeneration, Learning and Innovation in the Context of Sustainable Multidisciplinary Research

    Directory of Open Access Journals (Sweden)

    Florin Răzvan Bălășescu

    2010-07-01

    Full Text Available Objective The Lisbon Strategy set a new goal for the EU economy: the transition to a knowledge based economy, competitive and sustainable at macro and regional levels, by creating the European Research Area – a geographic area without frontiers for researches, where scientific resources are better managed to create more jobs and improve Europe's competitiveness. That means an interaction between specific and multidisciplinary research network. Approach However, general research methodology sustains the importance of static and revolutionary specific criteria of Scientific Research Programs but also reveals the natural process of multidisciplinary researches. In this context, the European Union could be regarded as a specific and multidisciplinary research area, as a network of flows, connections, relationships, interdependencies, and interferences between natural - experimental and social-humanistic research spheres (economics, management, sociology and complex systems ecology. Prior Work: In this respect some researchers suggested that both natural and social systems could be considered as multidisciplinary complex adaptive systems consisting of specific cluster network connections ( in the form of biotic and abiotic nodes, respectively, the competitive and regional poles with the ability to continuous self-organizing, learning and regenerating process especially in crisis situations. Implications and Value Paper Utility The present paper might be useful to illustrate the contribution of technical-economic and socio-ecological researches to increasing the sustainability framework of European Research Area by considering the transition from the R&D approach (development through research process to the L&D approach (development through learning process.

  12. Bringing ayahuasca to the clinical research laboratory.

    Science.gov (United States)

    Riba, Jordi; Barbanoj, Manel J

    2005-06-01

    Since the winter of 1999, the authors and their research team have been conducting clinical studies involving the administration of ayahuasca to healthy volunteers. The rationale for conducting this kind of research is twofold. First, the growing interest of many individuals for traditional indigenous practices involving the ingestion of natural psychotropic drugs such as ayahuasca demands the systematic study of their pharmacological profiles in the target species, i.e., human beings. The complex nature of ayahuasca brews combining a large number of pharmacologically active compounds requires that research be carried out to establish the safety and overall pharmacological profile of these products. Second, the authors believe that the study of psychedelics in general calls for renewed attention. Although the molecular and electrophysiological level effects of these drugs are relatively well characterized, current knowledge of the mechanisms by which these compounds modify the higher order cognitive processes in the way they do is still incomplete, to say the least. The present article describes the development of the research effort carried out at the Autonomous University of Barcelona, commenting on several methodological aspects and reviewing the basic clinical findings. It also describes the research currently underway in our laboratory, and briefly comments on two new studies we plan to undertake in order to further our knowledge of the pharmacology of ayahuasca.

  13. Die-back of Phragmites australis in European wetlands: an overview of the European Research Programme on Reed Die-Back and Progression (1993-1994)

    NARCIS (Netherlands)

    Van der Putten, W.H.

    1997-01-01

    Reed (Phragmites australis (Cav.) Trin. ex Steudel) is one of the dominant plant species in European land-water ecotones. During the past decades reed belts have died back, especially in central and eastern Europe. The aim of the European Research Programme on Reed Die-back and Progression (EUREED),

  14. The European internet-based patient and research database for primary immunodeficiencies: results 2004–06

    Science.gov (United States)

    Eades-Perner, A-M; Gathmann, B; Knerr, V; Guzman, D; Veit, D; Kindle, G; Grimbacher, B

    2007-01-01

    Because primary immunodeficiencies (PID) are rare diseases, transnational studies are essential to maximize the scientific outcome and lead to improved diagnosis and therapy. Immunologists in Europe have united to determine the prevalence of PID in Europe and to establish and evaluate harmonized guidelines for the diagnosis and treatment of PID as well as to improve the awareness of PID in Europe. In order to achieve this aim we have developed an internet-based database for clinical and research data on patients with PID. This database forms the platform for studies of demographics, the development of new diagnostic and therapeutic strategies and the identification of novel disease-associated genes. The database is completely secure, while providing access to researchers via a standard browser using password and encrypted log-in sessions and conforms to all European and national ethics and data protection guidelines. So far 2386 patients have been documented by 35 documenting centres in 20 countries. Common variable immunodeficiency (CVID) is the most common entity, accounting for almost 30% of all entries. First statistical analyses on the quality of life of patients show the advantages of immunoglobulin replacement therapy, at the same time revealing a mean diagnostic delay of over 4 years. First studies on specific questions on selected PID are now under way. The platform of this database can be used for any type of medical condition. PMID:17223972

  15. The European internet-based patient and research database for primary immunodeficiencies: results 2004-06.

    Science.gov (United States)

    Eades-Perner, A-M; Gathmann, B; Knerr, V; Guzman, D; Veit, D; Kindle, G; Grimbacher, B

    2007-02-01

    Because primary immunodeficiencies (PID) are rare diseases, transnational studies are essential to maximize the scientific outcome and lead to improved diagnosis and therapy. Immunologists in Europe have united to determine the prevalence of PID in Europe and to establish and evaluate harmonized guidelines for the diagnosis and treatment of PID as well as to improve the awareness of PID in Europe. In order to achieve this aim we have developed an internet-based database for clinical and research data on patients with PID. This database forms the platform for studies of demographics, the development of new diagnostic and therapeutic strategies and the identification of novel disease-associated genes. The database is completely secure, while providing access to researchers via a standard browser using password and encrypted log-in sessions and conforms to all European and national ethics and data protection guidelines. So far 2386 patients have been documented by 35 documenting centres in 20 countries. Common variable immunodeficiency (CVID) is the most common entity, accounting for almost 30% of all entries. First statistical analyses on the quality of life of patients show the advantages of immunoglobulin replacement therapy, at the same time revealing a mean diagnostic delay of over 4 years. First studies on specific questions on selected PID are now under way. The platform of this database can be used for any type of medical condition.

  16. European AIDS Clinical Society Standard of Care meeting on HIV and related coinfections

    DEFF Research Database (Denmark)

    Mussini, C; Antinori, A; Bhagani, S

    2016-01-01

    diagnosed multi-drug-resistant cases. Hepatitis C is widespread in selected geographical areas and risk groups. CONCLUSIONS: The key conclusion from the meeting was that a high-priority group of actions could be identified, including: increasing HIV awareness and testing, improving training for health care......OBJECTIVES: The objective of the 1st European AIDS Clinical Society meeting on Standard of Care in Europe was to raise awareness of the European scenario and come to an agreement on actions that could be taken in the future. METHODS: Data-driven presentations were given on specific topics followed...... by interactive panel discussions. RESULTS: In Eastern European countries, the epidemic is largely driven by injecting drug use, in contrast with Western Europe where the infection mainly occurs through heterosexual contact. A high proportion of people living with HIV remain unaware of their infection...

  17. European Society of Gastrointestinal Endoscopy - Establishing the key unanswered research questions within gastrointestinal endoscopy

    DEFF Research Database (Denmark)

    Rees, Colin J; Ngu, Wee Sing; Regula, Jaroslaw

    2016-01-01

    Background and study aim: Gastrointestinal endoscopy is a rapidly evolving research field. The European Society of Gastrointestinal Endoscopy (ESGE) plays a key role in shaping opinion and endoscopy activity throughout Europe and further afield. Establishing key unanswered questions within...... the field of endoscopy and prioritizing those that are important enables researchers and funders to appropriately allocate resources. Methods: Over 2 years, the ESGE Research Committee gathered information on research priorities and refined them through a modified Delphi approach. Consultations were held...... with the ESGE Governing Board and Quality Improvement Committee to identify important unanswered questions. Research workshops were held at the 21st United European Gastroenterology Week. Research questions were refined by the ESGE Research Committee and Governing Board, compiled into an online survey...

  18. Periprosthetic Joint Infections: Clinical and Bench Research

    Directory of Open Access Journals (Sweden)

    Laurence Legout

    2013-01-01

    Full Text Available Prosthetic joint infection is a devastating complication with high morbidity and substantial cost. The incidence is low but probably underestimated. Despite a significant basic and clinical research in this field, many questions concerning the definition of prosthetic infection as well the diagnosis and the management of these infections remained unanswered. We review the current literature about the new diagnostic methods, the management and the prevention of prosthetic joint infections.

  19. Partners | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Developmental Studies Hybridoma Bank at the University of Iowa NCI’s OCCPR works closely with The University of Iowa's Developmental Studies Hybridoma Bank (DSHB) that distributes all hybridomas and monoclonal antibodies from NCI's Clinical Proteomic Technologies for Cancer initiative (CPTC). DSHB supplies researchers with monoclonal antibodies, which may be ordered as tissue culture supernatants, ascites, or concentrate; selected hybridomas are also available as frozen or growing cells.

  20. Periprosthetic Joint Infections: Clinical and Bench Research

    OpenAIRE

    Laurence Legout; Eric Senneville

    2013-01-01

    Prosthetic joint infection is a devastating complication with high morbidity and substantial cost. The incidence is low but probably underestimated. Despite a significant basic and clinical research in this field, many questions concerning the definition of prosthetic infection as well the diagnosis and the management of these infections remained unanswered. We review the current literature about the new diagnostic methods, the management and the prevention of prosthetic joint infections.

  1. AURORA BOREALIS - European Research Icebreaker With Drilling Capability

    Science.gov (United States)

    Biebow, N.; Lembke-Jene, L.; Kunz-Pirrung, M.; Thiede, J.

    2008-12-01

    The polar oceans are the least known areas of the globe, in although they hold the key to many of our climate´s secrets. How does the sea ice coverage and the sea water properties change? How do plants and animals survive under the most extreme conditions of the earth? Which information of past climate change can be read from the sediments at the sea-floor and how can the future changing climate be predicted? In order to answer such and further questions, for the moment a hypermodern research vessel, the AURORA BOREALIS, is planned, which can handle the cool summers and freezing winters of the polar oceans and which can drill deep into the sea floor. AURORA BOREALIS will be the most advanced Research Icebreaker in the world with a multi-functional role of drilling in deep ocean basins and supporting climate/environmental research and decision support for stakeholder governments for the next 35-40 years. It will have a high icebreaking capacity to penetrate autonomously (single ship operation) into the central Arctic Ocean with more than 2.5 meters of ice cover, during all seasons of the year. The new technological features will include dynamic positioning in closed sea- ice cover, satellite navigation and ice-management support and the deployment and operation of Remotely Operated Vehicles (ROV) and Autonomous Underwater Vehicles (AUVs) from the twin moon-pools. A unique feature of the vessel is the deep-sea drilling rig, which will enable sampling of the ocean floor and sub-sea up to 5000 m water and 1000 m penetration at the most inhospitable places on earth. The drilling capability will be deployed in both Polar Regions on the long run and AURORA BOREALIS will be the only vessel worldwide that could undertake this type of scientific investigation.

  2. Research, Education and Innovation Bundling Forces towards a Sustainable European Energy Future

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    New technologies and applied innovation in the field of sustainable energy are needed in order to achieve a competitive and climate neutral Europe. As one of the first three Knowledge and Innovation Communities (KIC) of the European Institute of Innovation and Technology (EIT), KIC InnoEnergy invests in innovation projects and new educational programmes and provides business creation service with the purpose of delivering the disruptive technologies and innovations that Europe requires to meet this ambitious goal. Its stakeholders are top European players in the industry, research institutes, universities and business schools. Six regionally bundled European hubs – Barcelona/Lisbon, Grenoble, Eindhoven, Karlsruhe, Stockholm and Krakow - lead one thematic field each in sustainable energy. The thematic fields addressed range from Intelligent “Energy-efficient Residential Buildings and Cities” over “Energy from Chemical Fuels”, “Renewable Energies”, “Clean Coal Technologies” to “European Smar...

  3. European network using fish as osteoporosis research models (ENFORM)

    Science.gov (United States)

    Goerlich, R.; Renn, J.; Alestrom, P.; Nouizadeh-Lillabadi, R.; Schartl, M.; Winkler, C.; Muller, M.; Midtyng, P. J.; Eberius, M.; Slenzka, K.

    2005-08-01

    Osteoporosis, characterised by loss of bone density, is one of the most important bone diseases of humans worldwide. It causes problems in post-menopausal women, in astronauts during long-term spaceflights and in industrial animal production. Bone alterations leading to osteoporosis are well-documented at the cellular level, but the underlying molecular events are still poorly understood and most of our knowledge is derived from in vitro studies using cell culture systems. Recent findings indicate a remarkable conservation of the key regulators of bone development and homeostasis between mammals and fish. Medaka (Oryzias latipes) and zebrafish (Danio rerio) offer experimental advantages that can be exploited for bone research.

  4. Research Directions in European Veterinary Pathology in 2010-2016 based on the Congresses of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists

    Directory of Open Access Journals (Sweden)

    Andrzej Dzikowski

    2017-11-01

    Full Text Available The objective of this paper is to depict the current research directions in veterinary pathology in Europe. The analysis was carried out based on the abstracts and agendas of the annual European Society of Veterinary Pathology (ESVP congresses organised together with the European College of Veterinary Pathologists (ECVP in 2010-2016. In total, 1444 presentations were evaluated, including 41 plenary lectures, 319 short oral presentations, and 1081 posters, and in 2016 also three science slams. It was found that infectious and parasitic diseases (467 presentations, 32.34% and oncology (450 presentations, 31.16% were the most commonly discussed topics. Organ pathology was also addressed (327 presentations, 22.65%, with the subsequent places taken by research on different topics (140 presentations, 9.70% and toxicopathology (67 presentations, 4.64%. Among the most commonly presented issues, there was a substantial number of presentations on neurology (129 speeches, 8.93% and mammary gland diseases (101 presentations, 6.99%. A downward trend was revealed for infectious and parasitic diseases and for oncology, and a positive trend for organ pathology, the first and the third being statistically significant.

  5. Research Directions in European Veterinary Pathology in 2010-2016 based on the Congresses of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists.

    Science.gov (United States)

    Dzikowski, Andrzej; Szarek, Józef; Babińska, Izabella; Felsmann, Mariusz Zbigniew; Popławski, Krystian; Gulda, Dominika; Wąsowicz, Krzysztof; Wiśniewska, Anna

    2017-01-01

    The objective of this paper is to depict the current research directions in veterinary pathology in Europe. The analysis was carried out based on the abstracts and agendas of the annual European Society of Veterinary Pathology (ESVP) congresses organised together with the European College of Veterinary Pathologists (ECVP) in 2010-2016. In total, 1444 presentations were evaluated, including 41 plenary lectures, 319 short oral presentations, and 1081 posters, and in 2016 also three science slams. It was found that infectious and parasitic diseases (467 presentations, 32.34%) and oncology (450 presentations, 31.16%) were the most commonly discussed topics. Organ pathology was also addressed (327 presentations, 22.65%), with the subsequent places taken by research on different topics (140 presentations, 9.70%) and toxicopathology (67 presentations, 4.64%). Among the most commonly presented issues, there was a substantial number of presentations on neurology (129 speeches, 8.93%) and mammary gland diseases (101 presentations, 6.99%). A downward trend was revealed for infectious and parasitic diseases and for oncology, and a positive trend for organ pathology, the first and the third being statistically significant.

  6. Negotiation skills for clinical research professionals

    Science.gov (United States)

    Hake, Sanjay; Shah, Tapankumar

    2011-01-01

    Negotiation as a skill is a key requirement for each and every job profile where dealing with multiple parties is involved. The important focus while negotiating should be on the interest then position. Key to every successful negotiation is advance planning, preparation, and patience as the objective is to create value and establish the terms on which parties with differing and often conflicting aims will co-operate. While preparing one should collect facts, know priorities, principles, identify common ground, decide on walk-away position, and try and identify the next best alternative. Negotiation is a set of skills that can be learned and practiced so that your ability to utilize relationship, knowledge, money, power, time, and personality to negotiate improves with each negotiation. In a successful negotiation, all parties win. Important thing to note is that not every negotiation involves money. Anytime you want something from someone else and anytime someone wants something from you, you are negotiating. Everything is negotiable and every day you negotiate with customers, suppliers, colleagues, your wife, and even your children. Negotiation is a game, and like any game it has its rules and tactics. Clinical Research professionals deal with various parties for different purposes at the same time; hence, they require excellent negotiation skills. Project Mangers and Clinical Research Associates are the two most important roles in clinical research industry who require negotiation skills as they deal with various internal and external customers and vendors. PMID:21897886

  7. Negotiation skills for clinical research professionals.

    Science.gov (United States)

    Hake, Sanjay; Shah, Tapankumar

    2011-07-01

    Negotiation as a skill is a key requirement for each and every job profile where dealing with multiple parties is involved. The important focus while negotiating should be on the interest then position. Key to every successful negotiation is advance planning, preparation, and patience as the objective is to create value and establish the terms on which parties with differing and often conflicting aims will co-operate. While preparing one should collect facts, know priorities, principles, identify common ground, decide on walk-away position, and try and identify the next best alternative. Negotiation is a set of skills that can be learned and practiced so that your ability to utilize relationship, knowledge, money, power, time, and personality to negotiate improves with each negotiation. In a successful negotiation, all parties win. Important thing to note is that not every negotiation involves money. Anytime you want something from someone else and anytime someone wants something from you, you are negotiating. Everything is negotiable and every day you negotiate with customers, suppliers, colleagues, your wife, and even your children. Negotiation is a game, and like any game it has its rules and tactics. Clinical Research professionals deal with various parties for different purposes at the same time; hence, they require excellent negotiation skills. Project Mangers and Clinical Research Associates are the two most important roles in clinical research industry who require negotiation skills as they deal with various internal and external customers and vendors.

  8. Negotiation skills for clinical research professionals

    Directory of Open Access Journals (Sweden)

    Sanjay Hake

    2011-01-01

    Full Text Available Negotiation as a skill is a key requirement for each and every job profile where dealing with multiple parties is involved. The important focus while negotiating should be on the interest then position. Key to every successful negotiation is advance planning, preparation, and patience as the objective is to create value and establish the terms on which parties with differing and often conflicting aims will co-operate. While preparing one should collect facts, know priorities, principles, identify common ground, decide on walk-away position, and try and identify the next best alternative. Negotiation is a set of skills that can be learned and practiced so that your ability to utilize relationship, knowledge, money, power, time, and personality to negotiate improves with each negotiation. In a successful negotiation, all parties win. Important thing to note is that not every negotiation involves money. Anytime you want something from someone else and anytime someone wants something from you, you are negotiating. Everything is negotiable and every day you negotiate with customers, suppliers, colleagues, your wife, and even your children. Negotiation is a game, and like any game it has its rules and tactics. Clinical Research professionals deal with various parties for different purposes at the same time; hence, they require excellent negotiation skills. Project Mangers and Clinical Research Associates are the two most important roles in clinical research industry who require negotiation skills as they deal with various internal and external customers and vendors.

  9. Civil society organisations and public health research--evidence from eight European union new member states.

    Science.gov (United States)

    Knabe, Agnese; McCarthy, Mark

    2012-12-01

    Civil society organisations (CSO) are not-for-profit, non-governmental organisations operating in the public interest. They are the "third sector" that is strongly developed in Western European countries, ensuring the link between citizens and government and working as a counterbalance to the business sector. Their role in support of public health research deserves attention. Within a broader European study (STEPS--Strengthening Engagement in Public Health Research), public health organisations in eight European Union new member states (Cyprus, Estonia, Latvia, Lithuania, Malta, Romania, Slovakia, Slovenia) identified national CSOs with interests in health. A questionnaire was developed jointly, translated into national languages and sent by e-mail to 474 organisations, with 128 completed responses (27%). Most CSOs would like to be more involved in setting or advising on public-health research policy, and greater collaboration between CSOs, professional organisations and governmental institutions. Respondents did not see CSOs directly doing research, but recommended mobilizing researchers and organsations, supporting research themes, and lobbying to use public health evidence in policy and decision-making. They could receive more education for, and discussion of, public health research, and offer support in applying for research funding. Civil society organisations can contribute importantly,in setting public health research agendas. Research commissioning should give greater recognition of this role, improve links between CSOs, researchers and governmental institutions, and develop a stronger shared basis for public health policy and practice.

  10. For the Anniversary Edition of the Scientific Journal European Researcher. Series A – 110 issue

    OpenAIRE

    Goran Rajović; JelisavkaBulatović

    2016-01-01

    This article is a review of the jubilee scientific journal "European Researcher. Series A ", marked at all in 2016 – the sixth anniversary, of regular and of continuous publication. In addition to the history of the newspaper are exposed to the development phase of its program concept. The journal is the period 2010 – 2016 year, profiled in an important factor of development and the formation of professional and scientific thought. Journal “European Research. Series A” is now open forum for p...

  11. The Human Brain Project: Creating a European Research Infrastructure to Decode the Human Brain.

    Science.gov (United States)

    Amunts, Katrin; Ebell, Christoph; Muller, Jeff; Telefont, Martin; Knoll, Alois; Lippert, Thomas

    2016-11-02

    Decoding the human brain is perhaps the most fascinating scientific challenge in the 21st century. The Human Brain Project (HBP), a 10-year European Flagship, targets the reconstruction of the brain's multi-scale organization. It uses productive loops of experiments, medical, data, data analytics, and simulation on all levels that will eventually bridge the scales. The HBP IT architecture is unique, utilizing cloud-based collaboration and development platforms with databases, workflow systems, petabyte storage, and supercomputers. The HBP is developing toward a European research infrastructure advancing brain research, medicine, and brain-inspired information technology. Copyright © 2016. Published by Elsevier Inc.

  12. Interpretation of correlations in clinical research.

    Science.gov (United States)

    Hung, Man; Bounsanga, Jerry; Voss, Maren Wright

    2017-11-01

    Critically analyzing research is a key skill in evidence-based practice and requires knowledge of research methods, results interpretation, and applications, all of which rely on a foundation based in statistics. Evidence-based practice makes high demands on trained medical professionals to interpret an ever-expanding array of research evidence. As clinical training emphasizes medical care rather than statistics, it is useful to review the basics of statistical methods and what they mean for interpreting clinical studies. We reviewed the basic concepts of correlational associations, violations of normality, unobserved variable bias, sample size, and alpha inflation. The foundations of causal inference were discussed and sound statistical analyses were examined. We discuss four ways in which correlational analysis is misused, including causal inference overreach, over-reliance on significance, alpha inflation, and sample size bias. Recent published studies in the medical field provide evidence of causal assertion overreach drawn from correlational findings. The findings present a primer on the assumptions and nature of correlational methods of analysis and urge clinicians to exercise appropriate caution as they critically analyze the evidence before them and evaluate evidence that supports practice. Critically analyzing new evidence requires statistical knowledge in addition to clinical knowledge. Studies can overstate relationships, expressing causal assertions when only correlational evidence is available. Failure to account for the effect of sample size in the analyses tends to overstate the importance of predictive variables. It is important not to overemphasize the statistical significance without consideration of effect size and whether differences could be considered clinically meaningful.

  13. Developing a European grid infrastructure for cancer research: vision, architecture and services.

    Science.gov (United States)

    Tsiknakis, M; Rueping, S; Martin, L; Sfakianakis, S; Bucur, A; Sengstag, T; Brochhausen, M; Pucaski, J; Graf, N

    2007-01-01

    Life sciences are currently at the centre of an information revolution. The nature and amount of information now available opens up areas of research that were once in the realm of science fiction. During this information revolution, the data-gathering capabilities have greatly surpassed the data-analysis techniques. Data integration across heterogeneous data sources and data aggregation across different aspects of the biomedical spectrum, therefore, is at the centre of current biomedical and pharmaceutical R&D.This paper reports on original results from the ACGT integrated project, focusing on the design and development of a European Biomedical Grid infrastructure in support of multi-centric, post-genomic clinical trials (CTs) on cancer. Post-genomic CTs use multi-level clinical and genomic data and advanced computational analysis and visualization tools to test hypotheses in trying to identify the molecular reasons for a disease and the stratification of patients in terms of treatment.The paper provides a presentation of the needs of users involved in post-genomic CTs and presents indicative scenarios, which drive the requirements of the engineering phase of the project. Subsequently, the initial architecture specified by the project is presented, and its services are classified and discussed. A range of such key services, including the Master Ontology on sCancer, which lie at the heart of the integration architecture of the project, is presented. Special efforts have been taken to describe the methodological and technological framework of the project, enabling the creation of a legally compliant and trustworthy infrastructure. Finally, a short discussion of the forthcoming work is included, and the potential involvement of the cancer research community in further development or utilization of the infrastructure is described.

  14. The European and Global Dimension of Mountain Research

    Directory of Open Access Journals (Sweden)

    Axel Borsdorf

    2009-06-01

    Full Text Available Au cours du siècle dernier, les régions montagneuses et leur système complexe sont sortis de l’ombre. La volonté de protéger ces régions a suscité de nombreuses initiatives dans le monde entier, avec pour objectif d’agir au niveau international et politique, mais également d’unir les forces disponibles pour intensifier l’inter et la transdisciplinarité des travaux scientifiques. Les défis de la recherche sur les montagnes à l’avenir seront de réussir à impliquer plus efficacement les politiciens, les parties prenantes et les habitants des régions montagneuses afin d’atténuer la pression de la mondialisation pour parvenir à un développement régional durable dans les zones montagneuses. Dresser un panorama des institutions qui représentent les régions de montagne de la planète a ainsi l’intérêt de présenter les principales préoccupations de chacune d’entre elles ainsi que les domaines dans lesquels elles travaillent.Within the last century the awareness of mountain regions and their complex system has grown and the motivation to protect these regions has yielded numerous initiatives around the globe with the aim of acting internationally and politically as well as joining forces to intensify inter– and transdisciplinarity in scientific work. The challenges of mountain research in the future will be to involve politicians, stakeholders and the mountain population more effectively in order to mitigate the pressures of globalization towards a sustainable regional development within mountain regions. The significance of providing an overview of institutions representing mountainous regions around the globe lies in showing the main focus of the different institutions and the areas they work in.

  15. [Alfredo Lanari, a clinical research style].

    Science.gov (United States)

    Romero, Lucía

    2012-01-01

    The institutionalization of clinical research in Argentina reached its point of greatest maturity with the creation, in 1957, of the Institute of Medical Investigations (Instituto de Investigaciones Médicas) of the Faculty of Medicine of the Universidad de Buenos Aires, and the drive of the man who was its director for almost 20 years, Alfredo Lanari. In this paper I analyze the ways in which he generated a style of clinical research and a referential position in local medical field that allowed him to carry out said institutional realization. This achievement was the result of a personal enterprise and at the same time part of a larger context of transformations within the medical discipline world-wide and at the Universidad de Buenos Aires. This study was carried out combining oral and documentary sources, such as interviews with physicians at the Institute of Medical Investigations, members of the journal Medicina and of the Argentine Society of Clinical Investigation (Sociedad Argentina de Investigación Clínica), as well as academic files and scientific articles.

  16. Cancer registration, public health and the reform of the European data protection framework: Abandoning or improving European public health research?

    Science.gov (United States)

    Andersen, Mette Rye; Storm, Hans H

    2015-06-01

    The importance of cancer- and other disease registries for planning, management and evaluation of healthcare systems has been shown repeatedly during the last 50 years. Complete and unbiased population-level analyses on routinely collected, individual data concerning health and personal characteristics can address significant concerns about risk factors for cancer and provide sound evidence about public health and the effectiveness of healthcare systems. The existence of quality controlled and comprehensive data in registries, allowed to be used for quality control, research and public health purposes are taken as granted by most health professionals and researchers. However, the current revision of the European Union (EU) data protection framework suggests a harmonisation of requirements for confidentiality and individual consent to data processing, likely at the expense of proper use of registry data in the health sector. Consequences of excessive confidentiality rules that may lead to missed data linkages have been simulated. The simulations provide one possible explanation for observed heterogeneity among some cancer incidence data. Further, public health, quality control and epidemiological research on large populations can no longer provide evidence for health interventions, if requirements for consent renders research impossible or where attempts to obtain consent from each data subject generates biased results. Health professionals should engage in the on-going debate on the Commission's proposal for a General Data Protection Regulation. The nature and use of registry data in public health research must be explained and known to policy-makers and the public. Use of cancer registry data and other epidemiological activity will terminate abruptly if an unnecessarily strict EU data protection regulation is adopted. Research based interventions, as well as the international recognised standing of cancer registries and register-based research institutions in

  17. The European Organization for Research and Treatment of Cancer approach to developing questionnaire modules: an update and overview. EORTC Quality of Life Study Group

    NARCIS (Netherlands)

    Sprangers, M. A.; Cull, A.; Groenvold, M.; Bjordal, K.; Blazeby, J.; Aaronson, N. K.

    1998-01-01

    The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Study Group has adopted a modular approach to quality of life (QoL) assessment in cancer clinical trials. The core instrument (the EORTC QLQ-C30) covers a range of QoL issues relevant to a broad spectrum of

  18. Is phosphoproteomics ready for clinical research?

    Science.gov (United States)

    Iliuk, Anton B; Tao, W Andy

    2013-05-01

    For many diseases such as cancer where phosphorylation-dependent signaling is the foundation of disease onset and progression, single-gene testing and genomic profiling alone are not sufficient in providing most critical information. The reason for this is that in these activated pathways the signaling changes and drug resistance are often not directly correlated with changes in protein expression levels. In order to obtain the essential information needed to evaluate pathway activation or the effects of certain drugs and therapies on the molecular level, the analysis of changes in protein phosphorylation is critical. Existing approaches do not differentiate clinical disease subtypes on the protein and signaling pathway level, and therefore hamper the predictive management of the disease and the selection of therapeutic targets. The mini-review examines the impact of emerging systems biology tools and the possibility of applying phosphoproteomics to clinical research. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation.

    OpenAIRE

    Charman, Tony; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, Caroline; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen, Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas

    2017-01-01

    Abstract Background The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and expe...

  20. The European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life questionnaire cervical cancer module

    DEFF Research Database (Denmark)

    Greimel, Elfriede R; Kuljanic Vlasic, Karin; Waldenstrom, Ann-Charlotte

    2006-01-01

    BACKGROUND: The authors report on the development and validation of a cervical cancer module for the European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life (QoL) questionnaire (QLQ), which was designed to assess disease-specific and treatment-specific aspects of Qo...... with Cronbach alpha coefficients ranging from .72 to .87 (Symptom Experience, .72; Body Image, .86; Sexual/Vaginal Functioning, .87). Convergent and discriminant validity were fulfilled with scaling errors below 3%. The QLQ-CX24 was capable of discriminating between clinical subgroups. All items exhibited good...... compliance with validity and the reliability...

  1. The Problem of Competing Clinical and Research Goals in the Conduct of Clinical Nursing Research.

    Science.gov (United States)

    Van Dover, Leslie J.

    Because the science of nursing is still at an early stage of development, nurses involved in clinical research often find that no appropriate measures are available to sample the theoretical construct of interest. Researchers often must design and test new instruments before proceeding to test theory. A study of the effect of nurse-client…

  2. VISAGE: A Query Interface for Clinical Research.

    Science.gov (United States)

    Zhang, Guo-Qiang; Siegler, Trish; Saxman, Paul; Sandberg, Neil; Mueller, Remo; Johnson, Nathan; Hunscher, Dale; Arabandi, Sivaram

    2010-03-01

    We present the design and implementation of VISAGE (VISual AGgregator and Explorer), a query interface for clinical research. We follow a user-centered development approach and incorporate visual, ontological, searchable and explorative features in three interrelated components: Query Builder, Query Manager and Query Explorer. The Query Explorer provides novel on-line data mining capabilities for purposes such as hypothesis generation or cohort identification. The VISAGE query interface has been implemented as a significant component of Physio-MIMI, an NCRR-funded, multi-CTSA-site pilot project. Preliminary evaluation results show that VISAGE is more efficient for query construction than the i2b2 web-client.

  3. The clinical aspects of the acute facet syndrome: results from a structured discussion among European chiropractors

    Directory of Open Access Journals (Sweden)

    Jensen Tue

    2009-02-01

    Full Text Available Abstract Background The term 'acute facet syndrome' is widely used and accepted amongst chiropractors, but poorly described in the literature, as most of the present literature relates to chronic facet joint pain. Therefore, research into the degree of consensus on the subject amongst a large group of chiropractic practitioners was seen to be a useful contribution. Methods During the annual congress of The European Chiropractors Union (ECU in 2008, the authors conducted a workshop involving volunteer chiropractors. Topics were decided upon in advance, and the participants were asked to form into groups of four or five. The groups were asked to reach consensus on several topics relating to a basic case of a forty-year old man, where an assumption was made that his pain originated from the facet joints. First, the participants were asked to agree on a maximum of three keywords on each of four topics relating to the presentation of pain: 1. location, 2. severity, 3. aggravating factors, and 4. relieving factors. Second, the groups were asked to agree on three orthopaedic and three chiropractic tests that would aid in diagnosing pain from the facet joints. Finally, they were asked to agree on the number, frequency and duration of chiropractic treatment. Results Thirty-four chiropractors from nine European countries participated. They described the characteristics of an acute, uncomplicated facet syndrome as follows: local, ipsilateral pain, occasionally extending into the thigh with pain and decreased range of motion in extension and rotation both standing and sitting. They thought that the pain could be relieved by walking, lying with knees bent, using ice packs and taking non-steroidal anti-inflammatory drugs, and aggravated by prolonged standing or resting. They also stated that there would be no signs of neurologic involvement or antalgic posture and no aggravation of pain from sitting, flexion or coughing/sneezing. Conclusion The chiropractors

  4. Civil society engagement in innovation and research through the European Public Health Association.

    Science.gov (United States)

    Zeegers Paget, Dineke; Barnhoorn, Floris; McCarthy, Mark; Alexanderson, Kristina; Conceição, Claudia; Devillé, Walter; Grimaud, Olivier; Katreniakova, Zuzana; Narkauskaité, Laura; Saliba, Amanda; Sammut, Marvic; Voss, Margaretha

    2013-11-01

    The European Public Health Association (EUPHA) proposed and led PHIRE (Public Health Innovation and Research in Europe), with co-financing by the European Commission, to assess public health innovation and research at national level in Europe. PHIRE was also designed to promote organizational development and capacity building of EUPHA. We assess the success and limitations of using EUPHA's participative structures. In total, 30 European countries were included-27 EU countries, Iceland, Norway and Switzerland. EUPHA thematic section presidents were asked to identify country informants to report, through a web-based questionnaire, on eight public health innovations. National public health associations (EUPHA member organizations) were requested to identify their national public health research programmes and calls, review the health research system, coordinate a stakeholder workshop and provide a national report. The section and national reports were assessed for responses and completeness. Half of the final responding CIs were members of EUPHA sections and the other half gained from other sources. Experts declined to respond for reasons including lack of time, knowledge of the innovation or funding. National public health associations held PHIRE workshops with Ministries of Health in 14 countries; information for 10 countries was gained through discussions within the national association, or country visits by PHIRE partners. Six countries provided no response. Some national associations had too weak organizational structures for the work or insufficient financial resources or criticism of the project. EUPHA is the leading civil society organization giving support to public health research in Europe. PHIRE created new knowledge and supported organizational development. EUPHA sections gained expert reports on public health innovations in European countries and national public health associations reported on national public health research systems. Significant advances

  5. Infection control--a European research perspective for the next decade.

    NARCIS (Netherlands)

    Dettenkofer, M.; Ammon, A.; Astagneau, P.; Dancer, S.J.; Gastmeier, P.; Harbarth, S.; Humphreys, H.; Kern, W.V.; Lyytikainen, O.; Sax, H.; Voss, A.; Widmer, A.F.

    2011-01-01

    A symposium was held in June 2009 near Freiburg in Germany. Twenty-nine attendees from several European countries participated, most of whom are actively involved in research and hospital infection prevention and control. The following topics were presented and discussed: isolation and screening for

  6. Peripheral processing utilisation in CDC 6000 series machines at the European Nuclear Research Centre (CERN), Geneva

    CERN Document Server

    Letts, P J

    1972-01-01

    This paper gives some results from monitoring peripheral processor activity on CDC 6000 series machines at the European Nuclear Research Centre (CERN). It relates peripheral processor activity to a (single) central processor and argues that such an architecture is more likely to meet future user demands for higher levels of multiprogramming data security and error recovery. (12 refs).

  7. Menstrual questionnaires for clinical and research use.

    Science.gov (United States)

    Matteson, Kristen A

    2017-04-01

    Patient-reported outcome measures (PROMs) have the potential to be extremely valuable in the clinical care delivery for women who report heavy menstrual bleeding (HMB). Increasingly, studies on HMB have incorporated PROMs to evaluate the impact of bleeding on quality of life. These measures have included semiquantitative charts and pictograms, questionnaires to assess symptoms and impact on quality of life, and health-related quality of life questionnaires. Recent systematic reviews have highlighted inconsistency of outcome measurement across studies on HMB as a challenge limiting the interpretability of the body of literature and the ability to generate consensus on the relative effectiveness of treatment options. Consequently, research initiatives and international collaborations are working to harmonize outcome measurement. Harmonizing the use of questionnaires in research and clinical care has the potential to improve patient-centered care delivery for women with HMB and improve the generation of patient-focused evidence-based guidelines for the evaluation and treatment of HMB. Copyright © 2016. Published by Elsevier Ltd.

  8. Knowledge exchange in the CREATE project - Colour Research for European Advanced Technology Employment

    Science.gov (United States)

    Parraman, Carinna; Rizzi, Alessandro

    2011-01-01

    The presentation will review a four-year European funded project CREATE (Colour Research for European Advanced Technology Employment), which was established in 2006. The group came together to promote and exchange research and knowledge through a series of conferences and training courses to researchers working in Europe who were in the early stages of their career. The long-term objective was to address a broad range of themes in colour and to develop with artists, designers, technologists and scientists a cross disciplinary approach to improving colour communication and education and to provide a forum for dialogue between different fields. Now at the end of the funding programme, this paper will highlight some of the key milestones of the project. Moreover, having completed a supplementary workshop event in October 2010, researchers considered new themes for the future.

  9. The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: guide to the Register, version 3-2010

    DEFF Research Database (Denmark)

    McMurray, Janet; Zérah, Simone; Hallworth, Michael

    2010-01-01

    In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 12 years, more...... than 2200 specialists in Clinical Chemistry and Laboratory Medicine have joined the Register. In 2007, EC4 merged with the Forum of European Societies of Clinical Chemistry and Laboratory Medicine (FESCC) to form the European Federation of Clinical Chemistry and Laboratory Medicine (EFCC). Two previous...... Guides to the Register have been published, one in 1997 and another in 2003. The third version of the Guide is presented in this article and is based on the experience gained and development of the profession since the last revision. Registration is valid for 5 years and the procedure and criteria for re...

  10. The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: guide to the Register, version 3-2010.

    LENUS (Irish Health Repository)

    McMurray, Janet

    2010-07-01

    In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 12 years, more than 2200 specialists in Clinical Chemistry and Laboratory Medicine have joined the Register. In 2007, EC4 merged with the Forum of European Societies of Clinical Chemistry and Laboratory Medicine (FESCC) to form the European Federation of Clinical Chemistry and Laboratory Medicine (EFCC). Two previous Guides to the Register have been published, one in 1997 and another in 2003. The third version of the Guide is presented in this article and is based on the experience gained and development of the profession since the last revision. Registration is valid for 5 years and the procedure and criteria for re-registration are presented as an Appendix at the end of the article.

  11. The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: Code of Conduct, Version 2--2008.

    LENUS (Irish Health Repository)

    McMurray, Janet

    2009-01-01

    In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 10 years, more than 2000 specialists in Clinical Chemistry and Laboratory Medicine have joined the Register. In 2007, EC4 merged with the Federation of European Societies of Clinical Chemistry and Laboratory Medicine (FESCC) to form the European Federation of Clinical Chemistry and Laboratory Medicine (EFCC). A Code of Conduct was adopted in 2003 and a revised and updated version, taking account particularly of the guidelines of the Conseil Européen des Professions Libérales (CEPLIS) of which EFCC is a member, is presented in this article. The revised version was approved by the EC4 Register Commission and by the EFCC Executive Board in Paris on 6 November, 2008.

  12. Dark cities? Developing a methodology for researching dark tourism in European cities

    OpenAIRE

    Kennell, James; Powell, Raymond

    2016-01-01

    Despite the recent growth of research into dark tourism (Dale & Robinson, 2011; Lennon & Foley, 2000; Stone, 2013; Tarlow, 2005) and the growth of the dark tourism market (Biran & Hyde, 2013; Stone 2005; Stone & Sharpley, 2008), there has been little interest shown in understanding the relationship between dark tourism and urban tourism (Page & Hall 2002). This paper presents the initial findings of a research project that investigates the dark tourism products offered by European cities. A s...

  13. Advancements in NORM metrology - Results and impact of the European joint research project MetroNORM.

    Science.gov (United States)

    Josef Maringer, Franz; Baumgartner, Andreas; Cardellini, Francesco; Cassette, Philippe; Crespo, Teresa; Dean, Julian; Wiedner, Hannah; Hůlka, Jiři; Hult, Mikael; Jerome, Simon; Kabrt, Franz; Kovář, Petr; Larijani, Cyrus; Lutter, Guillaume; Marouli, Maria; Mauring, Alexander; Mazánová, Monika; Michalik, Bogusław; Michielsen, Nathalie; Peyres, Virginia; Pierre, Sylvie; Pöllänen, Roy; Pommé, Stefaan; Reis, Mário; Stietka, Michael; Szücs, László; Vodenik, Branko

    2017-08-01

    The results of the three years European Metrology Research Programme's (EMRP) joint research project 'Metrology for processing materials with high natural radioactivity' (MetroNORM) are presented. In this project, metrologically sound novel instruments and procedures for laboratory and in-situ NORM activity measurements have been developed. Additionally, standard reference materials and sources for traceable calibration and improved decay data of natural radionuclides have been established. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. CONSIDERATIONS ON EUROPEAN POLICY OF RESEARCH, DEVELOPMENT, INNOVATION. CASE OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Roxana Elena Lazăr

    2011-06-01

    Full Text Available The evolution of the European policy in the field of research, development, innovation reflects the maturity process of the European construction, through the very understanding of the particular role of knowledge in economy. An important aspect is the connection with the acknowledgment of the professional’s diplomas, which is based on the principle of automatism, on the mutual trust of the Member States in the qualifications obtained within the territory of any of them, on the tradition regarding the existence of a democratic and elitist education system. The improvement of the quality of education and the avoidance of sideslips are required. For the existence of a functional Euro-market in the field of research, development,innovation the differences between the European Union Member States have to be reduced, before attempting to catch up with the United States of America, Japan or China. Because knowledge is the inexhaustible resource of mankind in general, of the European Union, in particular, we should talk about a Union of Research, as we talk about the Monetary Union, for example. The strategy of economic growth in Romania was based on encouraging the consumers to spend money, but they didn’t consider a coherent policy based on innovations.

  15. Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

    NARCIS (Netherlands)

    Cingi, C.; Gevaert, P.; Mösges, R.; Rondon, C.; Hox, V.; Rudenko, M.; Muluk, N. B.; Scadding, G.; Manole, F.; Hupin, C.; Fokkens, W. J.; Akdis, C.; Bachert, C.; Demoly, P.; Mullol, J.; Muraro, A.; Papadopoulos, N.; Pawankar, R.; Rombaux, P.; Toskala, E.; Kalogjera, L.; Prokopakis, E.; Hellings, P. W.; Bousquet, J.

    2017-01-01

    This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms,

  16. European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence

    OpenAIRE

    Singh, Brahma N.; Saha, Chaitrali; Galun, Danijel; Upreti, Dalip K.; Bayry, Jagadeesh; Kaveri, Srini V.

    2016-01-01

    International audience; Viscum album L. or European mistletoe (Loranthaceae), a semi-parasitic shrub, has been used as a traditional medicine in Europe for centuries to treat various diseases like cancer, cardiovascular disorder, epilepsy, infertility, hypertension and arthritis. V. album contains diverse phytochemicals, which exert a large number of biological and pharmacological activities. The aim of this review is to compile the developments in the domain of V. album and research trends, ...

  17. Multidisciplinary quality assurance and control in oncological trials: Perspectives from European Organisation for Research and Treatment of Cancer (EORTC).

    Science.gov (United States)

    2017-11-01

    Quality assurance (QA) programmes are one of the mainstays of clinical research and constitute the pillars on which European Organisation for Research Treatment of Cancer (EORTC) delivers multidisciplinary therapeutic progress. Changing practice treatments require solid evidence-based data, which can only be achieved if integral QA is part of the infrastructure sustaining research projects. Cancer treatment is a multimodality approach, which is often applied either in sequence and/or in combination. Each modality plays a key role in cancer control. The modalities by which QA is applied varies substantially within and across the disciplines. In addition, translational and diagnostic disciplines take an increasing role in the era of precision medicine. Building on the structuring effect of clinical research with fully integrated multidisciplinary QA programmes associated with the solutions addressing the chain of custody for biological material and data integrity as well as compliance ensure at the same time validity of clinical research output but also have a training effect on health care providers, who are more likely to apply such principles as routine. The principles of QA are therefore critical to be embedded in multidisciplinary infrastructure to guarantee therapeutic progress. These principles also provide the basis for the functioning of multidisciplinary tumour board. However, technical, operational and economic challenges which go with the implementation of such programmes require optimal know-how and the coordination of the multiple expertise and such efforts are best achieved through centralised infrastructure. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Building the European Seismological Research Infrastructure: results from 4 years NERIES EC project

    Science.gov (United States)

    van Eck, T.; Giardini, D.

    2010-12-01

    The EC Research Infrastructure (RI) project, Network of Research Infrastructures for European Seismology (NERIES), implemented a comprehensive European integrated RI for earthquake seismological data that is scalable and sustainable. NERIES opened a significant amount of additional seismological data, integrated different distributed data archives, implemented and produced advanced analysis tools and advanced software packages and tools. A single seismic data portal provides a single access point and overview for European seismological data available for the earth science research community. Additional data access tools and sites have been implemented to meet user and robustness requirements, notably those at the EMSC and ORFEUS. The datasets compiled in NERIES and available through the portal include among others: - The expanded Virtual European Broadband Seismic Network (VEBSN) with real-time access to more then 500 stations from > 53 observatories. This data is continuously monitored, quality controlled and archived in the European Integrated Distributed waveform Archive (EIDA). - A unique integration of acceleration datasets from seven networks in seven European or associated countries centrally accessible in a homogeneous format, thus forming the core comprehensive European acceleration database. Standardized parameter analysis and actual software are included in the database. - A Distributed Archive of Historical Earthquake Data (AHEAD) for research purposes, containing among others a comprehensive European Macroseismic Database and Earthquake Catalogue (1000 - 1963, M ≥5.8), including analysis tools. - Data from 3 one year OBS deployments at three sites, Atlantic, Ionian and Ligurian Sea within the general SEED format, thus creating the core integrated data base for ocean, sea and land based seismological observatories. Tools to facilitate analysis and data mining of the RI datasets are: - A comprehensive set of European seismological velocity reference

  19. The European Court of Justice's decision regarding the Brüstle patent and its implications for the legality of stem cell research within the European Union.

    Science.gov (United States)

    Heyer, Martin; Spranger, Tade Matthias

    2013-12-01

    In 2011 the European Court of Justice issued a decision regarding the patentability of technologies derived from human embryonic stem cells. The finding will have an impact on the framework of stem cell research within the European Union and its Member States and has already triggered several political initiatives regarding the funding of research with human embryonic stem cells on the European level as well as a renewed public debate. This article will take a short look at the case history and the findings of the court. It offers some critical comments regarding the findings' consistency with European and international regulations on intellectual property rights as well as some considerations on the possible impact of the case for other fields of law.

  20. 75 FR 57833 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2010-09-22

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit..., 2010......... Crowne Plaza Neurobiology-D November 19, 2010......... Crowne Plaza Pulmonary Medicine...

  1. 77 FR 64598 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2012-10-22

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Biomedical Laboratory Research and Development and Clinical Science Research and Development Services..., 2012...... *VA Central Office. Cellular and Molecular Medicine...... November 19, 2012...... Sheraton...

  2. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study

    National Research Council Canada - National Science Library

    Luca, G. De; Haba-Rubio, J; Dauvilliers, Y; Lammers, G.J; Overeem, S; Donjacour, C.E; Mayer, G; Javidi, S; Iranzo, A; Santamaria, J; Peraita-Aados, R; Hor, H; Kutalik, Z; Plazzi, G; Poli, F; Pizza, F; Arnulf, I; Leceneux, M; Bassetti, C; Mathis, J; Heinzer, R; Jennum, P; Knudsen, S; Geisler, P; Wierzbicka, A; Feketeova, E; Pfister, C; Khatami, R; Baumann, C; Tafti, M

    2013-01-01

    The aim of this study was to describe the clinical and PSG characteristics of narcolepsy with cataplexy and their genetic predisposition by using the retrospective patient database of the European Narcolepsy Network (EU-NN...

  3. Recent developments in genetics and medically assisted reproduction: from research to clinical applications.

    Science.gov (United States)

    Harper, J C; Aittomäki, K; Borry, P; Cornel, M C; de Wert, G; Dondorp, W; Geraedts, J; Gianaroli, L; Ketterson, K; Liebaers, I; Lundin, K; Mertes, H; Morris, M; Pennings, G; Sermon, K; Spits, C; Soini, S; van Montfoort, A P A; Veiga, A; Vermeesch, J R; Viville, S; Macek, M

    2018-01-01

    Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

  4. Clinical Research, Dental Education, and the NIH Clinical Research Training Program.

    Science.gov (United States)

    Baum, Bruce J.; Davis, Clifford

    1998-01-01

    An expert panel, convened by the National Institutes of Health to address concerns about the future of clinical research, describes a training program at the National Institutes of Health that also included dental students. Possible reasons for low application rates among dental students are ascribed to inadequate dissemination of information,…

  5. Metrology for Radiological Early Warning Networks in Europe ("METROERM")-A Joint European Metrology Research Project.

    Science.gov (United States)

    Neumaier, Stefan; Dombrowski, Harald; Kessler, Patrick

    2016-08-01

    As a consequence of the Chernobyl nuclear power plant accident in 1986, all European countries have installed automatic dosimetry network stations as well as air sampling systems for the monitoring of airborne radioactivity. In Europe, at present, almost 5,000 stations measure dose rate values in nearly real time. In addition, a few hundred air samplers are operated. Most of them need extended accumulation times with no real-time capability. National dose rate data are provided to the European Commission (EC) via the EUropean Radiological Data Exchange Platform (EURDEP). In case of a nuclear emergency with transboundary implications, the EC may issue momentous recommendations to EU member states based on the radiological data collected by EURDEP. These recommendations may affect millions of people and could have severe economic and sociological consequences. Therefore, the reliability of the EURDEP data is of key importance. Unfortunately, the dose rate and activity concentration data are not harmonized between the different networks. Therefore, within the framework of the European Metrology Research Programme (EMRP), 16 European institutions formed the consortium MetroERM with the aim to improve the metrological foundation of measurements and to introduce a pan-European harmonization for the collation and evaluation of radiological data in early warning network systems. In addition, a new generation of detector systems based on spectrometers capable of providing both reliable dose rate values as well as nuclide specific information in real time are in development. The MetroERM project and its first results will be presented and discussed in this article.

  6. Public funding for research on antibacterial resistance in the JPIAMR countries, the European Commission, and related European Union agencies: a systematic observational analysis.

    Science.gov (United States)

    Kelly, Ruth; Zoubiane, Ghada; Walsh, Desmond; Ward, Rebecca; Goossens, Herman

    2016-04-01

    Antibacterial resistant infections are rising continuously, resulting in increased morbidity and mortality worldwide. With no new antibiotic classes entering the market and the possibility of returning to the pre-antibiotic era, the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) was established to address this problem. We aimed to quantify the scale and scope of publicly funded antibacterial resistance research across JPIAMR countries and at the European Union (EU) level to identify gaps and future opportunities. We did a systematic observational analysis examining antibacterial resistance research funding. Databases of funding organisations across 19 countries and at EU level were systematically searched for publicly funded antibacterial resistance research from Jan 1, 2007, to Dec 31, 2013. We categorised studies on the basis of the JPIAMR strategic research agenda's six priority topics (therapeutics, diagnostics, surveillance, transmission, environment, and interventions) and did an observational analysis. Only research funded by public funding bodies was collected and no private organisations were contacted for their investments. Projects in basic, applied, and clinical research, including epidemiological, public health, and veterinary research and trials were identified using keyword searches by organisations, and inclusion criteria were based on the JPIAMR strategic research agenda's six priority topics, using project titles and abstracts as filters. We identified 1243 antibacterial resistance research projects, with a total public investment of €1·3 billion across 19 countries and at EU level, including public investment in the Innovative Medicines Initiative. Of the total amount invested in antibacterial resistance research across the time period, €646·6 million (49·5%) was invested at the national level and €659·2 million (50·5%) at the EU level. When projects were classified under the six priority topics we found that 763 (63

  7. How novice, skilled and advanced clinical researchers include variables in a case report form for clinical research: a qualitative study.

    Science.gov (United States)

    Chu, Hongling; Zeng, Lin; Fetters, Micheal D; Li, Nan; Tao, Liyuan; Shi, Yanyan; Zhang, Hua; Wang, Xiaoxiao; Li, Fengwei; Zhao, Yiming

    2017-09-18

    Despite varying degrees in research training, most academic clinicians are expected to conduct clinical research. The objective of this research was to understand how clinical researchers of different skill levels include variables in a case report form for their clinical research. The setting for this research was a major academic institution in Beijing, China. The target population was clinical researchers with three levels of experience, namely, limited clinical research experience, clinicians with rich clinical research experience and clinical research experts. Using a qualitative approach, we conducted 13 individual interviews (face to face) and one group interview (n=4) with clinical researchers from June to September 2016. Based on maximum variation sampling to identify researchers with three levels of research experience: eight clinicians with limited clinical research experience, five clinicians with rich clinical research experience and four clinical research experts. These 17 researchers had diverse hospital-based medical specialties and or specialisation in clinical research. Our analysis yields a typology of three processes developing a case report form that varies according to research experience level. Novice clinician researchers often have an incomplete protocol or none at all, and conduct data collection and publication based on a general framework. Experienced clinician researchers include variables in the case report form based on previous experience with attention to including domains or items at risk for omission and by eliminating unnecessary variables. Expert researchers consider comprehensively in advance data collection and implementation needs and plan accordingly. These results illustrate increasing levels of sophistication in research planning that increase sophistication in selection for variables in the case report form. These findings suggest that novice and intermediate-level researchers could benefit by emulating the comprehensive

  8. European Communities Confederation of Clinical Chemistry Working Group on Accreditation: past, present and future.

    Science.gov (United States)

    Huisman, W

    2001-07-20

    During the past 10 years, many activities have taken place in the field of quality systems and accreditation in medical laboratories. Each country in Europe has a slightly different approach. The Working Group on Accreditation of the European Communities Confederation of Clinical Chemistry (EC4) tries to support harmonisation of these efforts. For this purpose, they edited the Essential Criteria for quality systems of medical laboratories and supported the forthcoming International ISO standard "Quality management for the medical laboratory". At this moment, a Model Quality Manual is nearly ready for publication. The next items are setting up criteria for auditing the quality system and criteria for the accreditation process.

  9. NFFA-Europe: enhancing European competitiveness in nanoscience research and innovation (Conference Presentation)

    Science.gov (United States)

    Carsughi, Flavio; Fonseca, Luis

    2017-06-01

    NFFA-EUROPE is an European open access resource for experimental and theoretical nanoscience and sets out a platform to carry out comprehensive projects for multidisciplinary research at the nanoscale extending from synthesis to nanocharacterization to theory and numerical simulation. Advanced infrastructures specialized on growth, nano-lithography, nano-characterization, theory and simulation and fine-analysis with Synchrotron, FEL and Neutron radiation sources are integrated in a multi-site combination to develop frontier research on methods for reproducible nanoscience research and to enable European and international researchers from diverse disciplines to carry out advanced proposals impacting science and innovation. NFFA-EUROPE will enable coordinated access to infrastructures on different aspects of nanoscience research that is not currently available at single specialized ones and without duplicating their specific scopes. Approved user projects will have access to the best suited instruments and support competences for performing the research, including access to analytical large scale facilities, theory and simulation and high-performance computing facilities. Access is offered free of charge to European users and users will receive a financial contribution for their travel, accommodation and subsistence costs. The users access will include several "installations" and will be coordinated through a single entry point portal that will activate an advanced user-infrastructure dialogue to build up a personalized access programme with an increasing return on science and innovation production. The own research activity of NFFA-EUROPE will address key bottlenecks of nanoscience research: nanostructure traceability, protocol reproducibility, in-operando nano-manipulation and analysis, open data.

  10. Towards rigour in qualitative health and social research across European partnerships.

    Science.gov (United States)

    Billings, Jenny

    2004-12-01

    Undertaking projects with European partners is an enterprising and rewarding activity, where societies can start to learn how to transfer knowledge and take advantage of best practices to further the benefits to health and social care service users. However, this can also be a challenging experience, more so when there is scanty guidance about the best way to conduct European partnership research. Using an on-going study of integrated care for older persons as an example (the PROCARE project), this paper provides an account of the methodological strengths and challenges of the qualitative approach used. It suggests that factors assisting a rigorous approach include sound and inclusive coordination, a strong research design, the construction of universally acceptable selection criteria, detailed interview schedules, and a transversal approach to data analysis.

  11. For the Anniversary Edition of the Scientific Journal European Researcher. Series A – 110 issue

    Directory of Open Access Journals (Sweden)

    Goran Rajović

    2016-09-01

    Full Text Available This article is a review of the jubilee scientific journal "European Researcher. Series A ", marked at all in 2016 – the sixth anniversary, of regular and of continuous publication. In addition to the history of the newspaper are exposed to the development phase of its program concept. The journal is the period 2010 – 2016 year, profiled in an important factor of development and the formation of professional and scientific thought. Journal “European Research. Series A” is now open forum for publicizing and stimulating innovative thinking on all aspects of the social sciences, the entire international academic community. In all this we emphasize the infinite persistence, creative energy but also authoring and management merits chief editor and founder of the Journal, DrAleksandrCherkasov for survival and development for this great publishing project.

  12. Obstacles to European research projects with data and tissue: solutions and further challenges.

    Science.gov (United States)

    van Veen, Evert-Ben

    2008-07-01

    Most European biomedical research projects are about data. Research with tissue is about data as well; data will accompany the tissue, and data will be derived from analysing the tissue. Data can be merged with data from various sources, copied and re-analysed in the context of European projects. Privacy enhancing technologies (PET) should be used for transferring data from participating centres to the level where data are being merged. PET provide coding techniques which allow donors to be anonymous and still uniquely discernable. It is defended that under certain conditions two-way coded data can be considered as anonymous data in the sense of the European Data Protection Directive. Divergent interpretations of this Directive and most of all about the concept of coded-anonymous data is one of the main obstacles to observational research in Europe. The Data Protection Authorities will have to relax the extremely high threshold before data cannot be considered personal data anymore. Arguments are given for such relaxation. Besides the logic and logistics of data transfer in European projects, it is also about trust and a realistic risk assessment. In spite of the massive dataflow in European research projects no breach of confidentiality has ever been reported. The ethical rationale of such projects can be based on the principles of citizenship and solidarity provided that certain safeguards are met by which that research will remain observational. However, if the project does not preclude individual feed-back on the outcomes of research, as in theory would be possible with two-way coded tissue, that tissue cannot be considered anonymous. It is argued that in most tissuebanking projects individual feed-back should be excluded. Tissuebanking for research should not turn into medical screening without applying the established criteria for screening to it. If individual feed-back is not foreseen, two-way tissue should be considered anonymous, under the same conditions

  13. Clinical Trials: A Crucial Key to Human Health Research

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Clinical Trials: A Crucial Key to Human Health Research Past ... the forefront of human health research today are clinical trials—studies that use human volunteers to help medical ...

  14. Children's self reported discomforts as participants in clinical research

    NARCIS (Netherlands)

    Staphorst, Mira S.; Hunfeld, Joke A. M.; van de Vathorst, Suzanne; Passchier, Jan; van Goudoever, Johannes B.

    2015-01-01

    There is little empirical evidence on children's subjective experiences of discomfort during clinical research procedures. Therefore, Institutional Review Boards have limited empirical information to guide their decision-making on discomforts for children in clinical research. To get more insight

  15. Children's self reported discomforts as participants in clinical research.

    NARCIS (Netherlands)

    Staphorst, M.S.; Hunfeld, J.A.M.; van de Vathorst, S.; Passchier, J.; van Goudoever, J.B.

    2015-01-01

    Introduction: There is little empirical evidence on children's subjective experiences of discomfort during clinical research procedures. Therefore, Institutional Review Boards have limited empirical information to guide their decision-making on discomforts for children in clinical research. To get

  16. Accelerating science and innovation societal benefits of European research in Particle Physics

    CERN Multimedia

    Radford, Tim; Jakobsson, Camilla; Marsollier, Arnaud; Mexner, Vanessa; O'Connor, Terry

    2013-01-01

    The story so far. Collaborative research in particle physics. The lesson for Europe: co-operation pays. Medicine and life sciences. The body of knowledge: particles harnessed for health. Energy and the environment. Think big: save energy and clean up the planet. Communication and new technologies. The powerhouse of invention. Society and skills. Power to the people. The European Strategy for Particle Physics. Update 2013.

  17. Measuring International Technology Spillovers and Progress Towards the European Research Area

    OpenAIRE

    SIEDSCHLAG, IULIA

    2009-01-01

    The objective of this paper is to contribute to the development of an evidence-based system to monitor progress towards the European Research Area (ERA) and a knowledge-based economy. We start with an overview of existing theory and empirical evidence on the role of international technology spillovers on economic growth. Further, we discuss the transmission channels of international technology spillovers and barriers to international technology diffusion. Next we turn to measuring specialisat...

  18. Addiction research centres and the nurturing of creativity. Monitoring the European drug situation: the ongoing challenge for the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).

    Science.gov (United States)

    Griffiths, Paul; Mounteney, Jane; Lopez, Dominique; Zobel, Frank; Götz, Wolfgang

    2012-02-01

    The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is the designated hub for drug-related information in the European Union. The organization's role is to provide the European Union (EU) and its Member States with a factual overview of European drug problems and a common information framework to support the drugs debate. In order to achieve its mission, the EMCDDA coordinates and relies on a network of 30 national monitoring centres, the Reitox National Focal Points. The Centre publishes on a wide range of drug-related topics, across epidemiology, interventions, laws and policies. Every November, the EMCDDA publishes its Annual Report, providing a yearly update on the European drug situation, translated into 23 EU languages. In line with its founding regulation, the EMCDDA has a role acting as an interface between the worlds of science and policy. While not a research centre in the formal sense, the results the Centre generates serve as catalysts for new research questions and help to identify priorities. Current challenges facing the agency include continuing to increase scientific standards while maintaining a strong institutional role, as well as supporting European efforts to identify, share and codify best practice in the drugs field. © 2011 EMCDDA.

  19. International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18.

    Science.gov (United States)

    Chie, Wei-Chu; Blazeby, Jane M; Hsiao, Chin-Fu; Chiu, Herng-Chia; Poon, Ronnie T; Mikoshiba, Naoko; Al-Kadhimi, Gillian; Heaton, Nigel; Calara, Jozer; Collins, Peter; Caddick, Katharine; Costantini, Anna; Vilgrain, Valerie; Trinquart, Ludovic; Chiang, Chieh

    2012-04-01

    This international field validation study examined the psychometric properties and clinical validity of the European Organization for Research and Treatment of Cancer (EORTC) questionnaire module for hepatocellular carcinoma (HCC), the EORTC quality-of-life questionnaire (QLQ)-HCC18. The EORTC QLQ-HCC18 was administered with the core questionnaire, the EORTC QLQ-C30, to 272 patients from seven centers in 6 countries. Patient acceptability of the module was examined with a debriefing questionnaire, and psychometric and clinical properties were assessed. Multitrait scaling analyses confirmed the hypothesized scale structure without any scaling error, and the fatigue scale demonstrated satisfactory internal consistency. The test-retest reliability scores were high for all scales, except abdominal swelling and sexual interest. The correlations between all scales of the QLQ-HCC18 and the QLQ-C30 were low or moderate, and many scales could distinguish patients with different clinical conditions. The module demonstrated responsiveness to clinical change in pain before and after surgery and some borderline change in patients undergoing systemic treatment. The EORTC QLQ-HCC18 can be used as a supplementary module for the EORTC QLQ-C30 in clinical trials for patients with HCC. Copyright © 2011 American Association for the Study of Liver Diseases.

  20. What Are the Main Drivers of Young Consumers Purchasing Traditional Food Products? European Field Research.

    Science.gov (United States)

    Vlontzos, George; Kyrgiakos, Leonidas; Duquenne, Marie Noelle

    2018-02-12

    In this research, the attitude of European young adults (age 18 to 30 years) regarding their consumption of local and traditional products was examined. The survey was conducted on a sample of 836 consumers from seven European countries (Greece, Bulgaria, Romania, Slovenia, Croatia, Denmark and France). Data collection was made by distributing a developed questionnaire through social media and university mail services. Principal Component Analysis (PCA) was used to identify consumer perception comparing the overall sample with two subsets (consumers from Eastern and Western European countries). Six major factors were revealed: consumer behavior, uncertainty about health issues, cost, influence of media and friends and availability in store. Young adults had a positive attitude to local and traditional food products, but they expressed insecurity about health issues. Cost factor had less of an influence on interviewees from Eastern European countries than those from the overall sample (3rd and 5th factor accordingly). Influence of close environment was a different factor in Eastern countries compared to Western ones, for which it was common to see an influence from media. Females and older people (25-30 years old) have fewer doubts about Traditional Food Products, while media have a high influence on consumers' decisions. The aim of this survey was to identify the consumer profiles of young adults and create different promotion strategies of local and traditional products among the two groups of countries.

  1. A European Flood Database: facilitating comprehensive flood research beyond administrative boundaries

    Directory of Open Access Journals (Sweden)

    J. Hall

    2015-06-01

    Full Text Available The current work addresses one of the key building blocks towards an improved understanding of flood processes and associated changes in flood characteristics and regimes in Europe: the development of a comprehensive, extensive European flood database. The presented work results from ongoing cross-border research collaborations initiated with data collection and joint interpretation in mind. A detailed account of the current state, characteristics and spatial and temporal coverage of the European Flood Database, is presented. At this stage, the hydrological data collection is still growing and consists at this time of annual maximum and daily mean discharge series, from over 7000 hydrometric stations of various data series lengths. Moreover, the database currently comprises data from over 50 different data sources. The time series have been obtained from different national and regional data sources in a collaborative effort of a joint European flood research agreement based on the exchange of data, models and expertise, and from existing international data collections and open source websites. These ongoing efforts are contributing to advancing the understanding of regional flood processes beyond individual country boundaries and to a more coherent flood research in Europe.

  2. 76 FR 79273 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2011-12-21

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Eligibility of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... biomedical, behavioral, and clinical science research. The panel meeting will be open to the public for...

  3. The European Research on Severe Accidents in Generation-II and -III Nuclear Power Plants

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Van Dorsselaere

    2012-01-01

    Full Text Available Forty-three organisations from 22 countries network their capacities of research in SARNET (Severe Accident Research NETwork of excellence to resolve the most important remaining uncertainties and safety issues on severe accidents in existing and future water-cooled nuclear power plants (NPP. After a first project in the 6th Framework Programme (FP6 of the European Commission, the SARNET2 project, coordinated by IRSN, started in April 2009 for 4 years in the FP7 frame. After 2,5 years, some main outcomes of joint research (modelling and experiments by the network members on the highest priority issues are presented: in-vessel degraded core coolability, molten-corium-concrete-interaction, containment phenomena (water spray, hydrogen combustion…, source term issues (mainly iodine behaviour. The ASTEC integral computer code, jointly developed by IRSN and GRS to predict the NPP SA behaviour, capitalizes in terms of models the knowledge produced in the network: a few validation results are presented. For dissemination of knowledge, an educational 1-week course was organized for young researchers or students in January 2011, and a two-day course is planned mid-2012 for senior staff. Mobility of young researchers or students between the European partners is being promoted. The ERMSAR conference is becoming the major worldwide conference on SA research.

  4. Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

    Directory of Open Access Journals (Sweden)

    Anja Ten Brinke

    2015-01-01

    Full Text Available The number of patients with autoimmune diseases and severe allergies and recipients of transplants increases worldwide. Currently, these patients require lifelong administration of immunomodulatory drugs. Often, these drugs are expensive and show immediate or late-occurring severe side effects. Treatment would be greatly improved by targeting the cause of autoimmunity, that is, loss of tolerance to self-antigens. Accumulating knowledge on immune mechanisms has led to the development of tolerogenic dendritic cells (tolDC, with the specific objective to restrain unwanted immune reactions in the long term. The first clinical trials with tolDC have recently been conducted and more tolDC trials are underway. Although the safety trials have been encouraging, many questions relating to tolDC, for example, cell-manufacturing protocols, administration route, amount and frequency, or mechanism of action, remain to be answered. Aiming to join efforts in translating tolDC and other tolerogenic cellular products (e.g., Tregs and macrophages to the clinic, a European COST (European Cooperation in Science and Technology network has been initiated—A FACTT (action to focus and accelerate cell-based tolerance-inducing therapies. A FACTT aims to minimize overlap and maximize comparison of tolDC approaches through establishment of minimum information models and consensus monitoring parameters, ensuring that progress will be in an efficient, safe, and cost-effective way.

  5. European research on children’s internet use: Assessing the past and anticipating the future

    OpenAIRE

    Livingstone, Sonia; Mascheroni, Giovanna; Staksrud, Elisabeth

    2017-01-01

    In this article, we reflect critically on the research agenda on children’s Internet use, framing our analysis using Wellman’s three ages of Internet studies and taking as our case study the three phases of research by the EU Kids Online network from 2006 to 2014. Following the heyday of moral panics, risk discourses and censorious policy-making that led to the European Commission’s first Internet Action Plan 1999–2002, EU Kids Online focused on conceptual clarification, evidence review and d...

  6. Observations and actions to ensure equal treatment of all candidates by the European Research Council

    Science.gov (United States)

    Rydin, Claudia Alves de Jesus; Farina Busto, Luis; El Mjiyad, Nadia; Kota, Jhansi; Thelen, Lionel

    2017-04-01

    The European Research Council (ERC), Europe's premiere funding agency for frontier research, views equality of opportunities as an important challenge. The ERC monitors closely gender figures on every call and has taken actions to tackle imbalances and potential unconscious biases. The ERC talk is focused on efforts made to understand and ensure equal treatment of all candidates, with particular focus on gender balance and with specific attention to geosciences. Data and statistics collected in running highly competitive and internationally recognised funding schemes are presented. Recent initiatives to tackle geographical imbalances will also be presented.

  7. Do's en don'ts in setting up European Research Infrastructures

    Science.gov (United States)

    Vermeulen, Alex

    2017-04-01

    The landscape of European research infrastructures (RIs), even when we just look at the area of environment, is mind-boggling complex. Why and how would you like to enter this world and what does it take? Some answers based on personal experience will be given. One of the most important issues for research infrastructures is how to provide access to the data and to make sure that in 20 or even 50 years from now people and machines can still make use of the RIs' data. What are the requirements for this and what tools are available now to accomplish this?

  8. Overview and status of the Next European Dipole (NED) joint research activity

    CERN Document Server

    Devred, Arnaud; Baynham, D Elwyn; Boutboul, T; Canfer, S; Chorowski, M; Fabbricatore, P; Farinon, S; Félice, H; Fessia, P; Fydrych, J; Granata, V; Greco, Michela; Greenhalgh, J; Leroy, D; Loveridge, P W; Matkowski, M; Michalski, G; Michel, F; Oberli, L R; den Ouden, A; Pedrini, D; Pietrowicz, S; Polinski, J; Previtali, V; Quettier, L; Richter, D; Rifflet, J M; Rochford, J; Rondeaux, F; Sanz, S; Scheuerlein, C; Schwerg, N; Sgobba, Stefano; Sorbi, M; Toral-Fernandez, F; Van Weelderen, R; Védrine, P; Volpini, G

    2006-01-01

    The Next European Dipole (NED) Joint Research Activity was launched on 1st January 2004 to promote the development of high performance Nb3Sn conductors in collaboration with European industry (aiming at a non-copper critical current density of 1500 A/mm2 at 4.2 K and 15 T) and to assess the suitability of Nb3Sn technology to the next generation of accelerator magnets (aiming at an aperture of 88 mm and a conductor peak field of ~ 15 T). It is part of the Coordinated Accelerator Research in Europe (CARE) project, involves eight collaborators and is half-funded by the European Union. After briefly recalling the Activity organization, we report the main progress achieved over the last year, which includes: the manufacturing of a double-bath He II cryostat for heat transfer measurements through Nb3Sn conductor insulation, detailed quench computations for various NED-like magnet configurations, the award of two industrial subcontracts for Nb3Sn conductor development, the first results of a cross-calibration progra...

  9. Overview and status of the Next European Dipole Joint Research Activity

    Science.gov (United States)

    Devred, A.; Baudouy, B.; Baynham, D. E.; Boutboul, T.; Canfer, S.; Chorowski, M.; Fabbricatore, P.; Farinon, S.; Félice, H.; Fessia, P.; Fydrych, J.; Granata, V.; Greco, M.; Greenhalgh, J.; Leroy, D.; Loverige, P.; Matkowski, M.; Michalski, G.; Michel, F.; Oberli, L. R.; den Ouden, A.; Pedrini, D.; Pietrowicz, S.; Polinski, J.; Previtali, V.; Quettier, L.; Richter, D.; Rifflet, J. M.; Rochford, J.; Rondeaux, F.; Sanz, S.; Scheuerlein, C.; Schwerg, N.; Sgobba, S.; Sorbi, M.; Toral-Fernandez, F.; van Weelderen, R.; Védrine, P.; Volpini, G.

    2006-03-01

    The Next European Dipole (NED) Joint Research Activity was launched on 1 January 2004 to promote the development of high-performance Nb3Sn conductors in collaboration with European industry (aiming at a non-copper critical current density of 1500 A mm-2 at 4.2 K and 15 T) and to assess the suitability of Nb3Sn technology to the next generation of accelerator magnets (aiming at an aperture of 88 mm and a conductor peak field of ~15 T). It is part of the Coordinated Accelerator Research in Europe (CARE) project, which involves eight collaborators, and is half-funded by the European Union. After briefly recalling the Activity organization, we report the main progress achieved over the last year, which includes: the manufacturing of a double-bath He II cryostat for heat transfer measurements through Nb3Sn conductor insulation, detailed quench computations for various NED-like magnet configurations, the award of two industrial subcontracts for Nb3Sn conductor development, the first results of a cross-calibration programme of test facilities for Nb3Sn wire characterization, detailed investigations of the mechanical properties of heavily cold-drawn Cu/Nb/Sn composite wires, and the preliminary assessment of a new insulation system based on polyimide-sized glass fibre tapes. Last, we briefly review the efforts of an ongoing Working Group on magnet design and optimization.

  10. Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines.

    Science.gov (United States)

    Stoffel, Elena M; Mangu, Pamela B; Gruber, Stephen B; Hamilton, Stanley R; Kalady, Matthew F; Lau, Michelle Wan Yee; Lu, Karen H; Roach, Nancy; Limburg, Paul J

    2015-01-10

    To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC) syndromes. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. The Familial Risk-Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guideline published in 2013 on behalf of the European Society for Medical Oncology (ESMO) Guidelines Working Group in Annals of Oncology was reviewed for developmental rigor by methodologists, with content and recommendations reviewed by an ASCO endorsement panel. The ASCO endorsement panel determined that the recommendations of the ESMO guidelines are clear, thorough, and based on the most relevant scientific evidence. The ASCO panel endorsed the ESMO guidelines and added a few qualifying statements. Approximately 5% to 6% of patient cases of CRC are associated with germline mutations that confer an inherited predisposition for cancer. The possibility of a hereditary cancer syndrome should be assessed for every patient at the time of CRC diagnosis. A diagnosis of Lynch syndrome, familial adenomatous polyposis, or another genetic syndrome can influence clinical management for patients with CRC and their family members. Screening for hereditary cancer syndromes in patients with CRC should include review of personal and family histories and testing of tumors for DNA mismatch repair deficiency and/or microsatellite instability. Formal genetic evaluation is recommended for individuals who meet defined criteria. © 2014 by American Society of Clinical Oncology.

  11. How to assess the emergence of the European Pirate Parties. Towards a research agenda

    Directory of Open Access Journals (Sweden)

    Radu Uszkai

    2012-06-01

    Full Text Available The purpose of this paper is to assess the emergence of the pirate movements in the European Union. Our goal is to sketch the steps towards a research agenda for this grassroots political movement which gained momentum since 2009. To attain our goal we showed the re-signification of the concept of piracy in the debate around intellectual property and its institutional settlement. Afterwards we analysed the big political themes of several European Pirate Parties and their struggle to follow the preferences of the median voter. We concluded with a set of hypotheses of which the most important is that the pirates will inscribe neither to the left nor to the right part of the political spectrum.

  12. Considerations regarding the expenses in the research and development sector of the European Union

    Directory of Open Access Journals (Sweden)

    Ecaterina Stănculescu

    2016-10-01

    Full Text Available This article aims to analyze the situation of the expenses (material resources in the research - development and innovation (RDI sector in the European Union, over the period 2000-2014. It examines their evolution in the considered period, as measured by expenditure intensity in the field, being revealed the gap between the EU and other states competing on the international market, i.e. the US, Japan and South Korea, showing that EU lags behind these countries. Outlook for material resources of the EU are determined by trends of new scientific and technical revolution and the transformations that the new technologies (mainly digital will produce in the human society as a whole. Article reveals the conclusions that can be drawn from the undertaken analysis, mainly that the European Union RDI sector requires an increased allocation of funds in the next period to achieve social objectives assumed by policy makers at EU and national level.

  13. First Tuesday@CERN: Industrial partnership and innovation management at European research laboratories

    CERN Multimedia

    2003-01-01

    On Wednesday 19 March, CERN will host for the second time the 'First Tuesday Geneva' events for entrepreneurs, investors and all those interested in new technologies. The event is organised by the non-profit group Rezonance. The theme of this "First Tuesday@CERN" is familiar to CERN, as it concerns new trends of industrial partnership and innovation management at European research laboratories. As major sources of innovative technologies, large laboratories such as CERN, ESA, EMBL or ESRF have adopted over the past few years new strategies in the areas of industrial partnership and technological spin-offs. Speakers include: - Pierre Brisson, Head of Technology Transfer and Promotion Office, ESA : "The European Space Incubator at ESA" - Gabor Lamm, Managing Director EMBL Enterprise Management Technology Transfer : "EMBL Enterprise Management: Innovation Works" - Edward Mitchell, Coordinator of the PSB, ESRF : "The Partnership for Structural Biology" - Wolfgang von Rüden, Leader of Information Tech...

  14. OpenAIRE - Building a collaborative Open Access infrastructure for European researchers

    Directory of Open Access Journals (Sweden)

    Najla Rettberg

    2012-11-01

    Full Text Available This paper outlines the efforts of the OpenAIRE networking team to establish a Europe-wide open access initiative. OpenAIRE is an effort to realize the open access policies of the European Commission, and has built an infrastructure to support the widest possible dissemination of project results within a certain funding area, FP7. The purpose of the paper is to highlight how such a service can be established through the work of a successful network of European open access contacts and by effective communication with a range of stakeholders. The paper also outlines the flexible technical infrastructure and research activities within the project. Not without its challenges, the approach to tackling existing barriers, such as building repository interoperability, are explored. The paper also introduces the aims and initial activities of the continuation project, OpenAIREplus.

  15. Historical European Martial Art a crossroad between academic research, martial heritage re-creation and martial sport practices

    Directory of Open Access Journals (Sweden)

    Jaquet Daniel

    2015-05-01

    Full Text Available Historical European martial arts (HEMA have to be considered an important part of our common European cultural heritage. Studies within this field of research have the potential to enlighten the puzzle posed by past societies, for example in the field of history, history of science and technology, or fields related to material culture.

  16. The power of science economic research and European decision-making : the case of energy and environment policies

    CERN Document Server

    Rossetti di Valdalbero, Domenico

    2010-01-01

    This book highlights the interaction between science and politics and between research in economics and European Union policy-making. It focuses on the use of Quantitative tools, Top-down and Bottom-up models in up-stream European decision-making process through five EU policy case studies: energy taxation, climate change, energy efficiency, renewable energy, and internalisation of external costs.

  17. The Effects of International Mobility on European Researchers: Comparing Intra-EU and U.S. Mobility

    Science.gov (United States)

    Veugelers, Reinhilde; Van Bouwel, Linda

    2015-01-01

    Using econometric analysis on survey data from European-born and European-educated researchers who are internationally mobile after their PhD within Europe or to the United States, we find significant positive effects from international mobility on scientific productivity, as well as several other positive career development effects. European…

  18. TEAC-Health--research-based recommendations for European certification of health telematics services.

    Science.gov (United States)

    Forsström, J; Rigby, M

    2000-01-01

    Health Telematics services are now a major part of health care delivery, and of citizens' health behaviour, and will rapidly develop further in scope and significance. However, despite their pivotal position in care and treatment, they are unregulated--unlike all other aspects of health care services. This anomaly is potentially putting the citizen at risk, and also underpinning good clinical practice as clinicians are uncertain of the integrity of specific health telematics tools. The TEAC-Health project, funded by the European Commission, has studied the issues, and produced evidence-based recommendations.

  19. Towards Horizon 2020: challenges and advances for clinical mental health research – outcome of an expert survey

    Science.gov (United States)

    van der Feltz-Cornelis, Christina M; van Os, Jim; Knappe, Susanne; Schumann, Gunter; Vieta, Eduard; Wittchen, Hans-Ulrich; Lewis, Shôn W; Elfeddali, Iman; Wahlbeck, Kristian; Linszen, Donald; Obradors-Tarragó, Carla; Haro, Josep Maria

    2014-01-01

    Background The size and increasing burden of disease due to mental disorders in Europe poses substantial challenges to its population and to the health policy of the European Union. This warrants a specific research agenda concerning clinical mental health research as one of the cornerstones of sustainable mental health research and health policy in Europe. The aim of this research was to identify the top priorities needed to address the main challenges in clinical research for mental disorders. Methods The research was conducted as an expert survey and expert panel discussion during a scientific workshop. Results Eighty-nine experts in clinical research and representing most European countries participated in this survey. Identified top priorities were the need for new intervention studies, understanding the diagnostic and therapeutic implications of mechanisms of disease, and research in the field of somatic-psychiatric comorbidity. The “subjectivity gap” between basic neuroscience research and clinical reality for patients with mental disorders is considered the main challenge in psychiatric research, suggesting that a shift in research paradigms is required. Conclusion Innovations in clinical mental health research should bridge the gap between mechanisms underlying novel therapeutic interventions and the patient experience of mental disorder and, if present, somatic comorbidity. Clinical mental health research is relatively underfunded and should receive specific attention in Horizon 2020 funding programs. PMID:25061300

  20. Overview of ESSL's severe convective storms research using the European Severe Weather Database ESWD

    Science.gov (United States)

    Dotzek, Nikolai; Groenemeijer, Pieter; Feuerstein, Bernold; Holzer, Alois M.

    Severe thunderstorms constitute a major weather hazard in Europe, with an estimated total damage of 5-8 billion euros each year nowadays. Even though there is an upward trend in damage due to increases in vulnerability and possibly also due to climate change impacts, a pan-European database of severe thunderstorm reports in a homogeneous data format did not exist until a few years ago. The development of this European Severe Weather Database (ESWD) provided the final impetus for the establishment of the European Severe Storms Laboratory (ESSL) as a non-profit research organisation in 2006, after having started as an informal network in 2002. Our paper provides an overview of the first research results that have been achieved by ESSL. We start by outlining the reporting practice and quality-control procedure for the database, which has been enhanced by a major software upgrade in the fall of 2008. It becomes apparent that the state of reporting converges to a realistic description of the severe storms climatology, corroborating, for instance, earlier estimates of tornado occurrence in Europe. Nevertheless, a further rise in the number of reported events must be expected, even without the presence of any physical trends. The European tornado and damaging wind intensity distributions as a function of the Fujita scale are quantitatively similar to long-term distributions from the USA, except for a strong underreporting of weak events (F0) that still persists in Europe. In addition, the ESSL has recently proposed a new wind speed scale, the Energy- or " E-scale" which is linked to physical quantities and can be calibrated. Finally, we demonstrate the large potential of ESWD data use for forecast or nowcasting/warning verification purposes.

  1. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection

    NARCIS (Netherlands)

    Debast, S.B.; Bauer, M.P.; Kuijper, E.J.

    2014-01-01

    In 2009 the first European Society of Clinical Microbiology and Infection (ESCMID) treatment guidance document for Clostridium difficile infection (CDI) was published. The guideline has been applied widely in clinical practice. In this document an update and review on the comparative effectiveness

  2. Pediatric biobanking: a pilot qualitative survey of practices, rules and researcher opinions in ten European countries

    DEFF Research Database (Denmark)

    Salvaterra, Elena; Giorda, Roberto; Bassi, Maria Teresa

    2012-01-01

    and data handling, and return of results as faced in 10 European countries. Because of the lack of comparative analyses of these topics, a pilot study was designed. Following a qualitative methodology, a questionnaire draft mostly including open-ended queries was developed, tested, and sent by e...... such as decision making, privacy protection, minor recontact, and research withdrawal by focusing on theoretical or empirical perspectives. Our research attempted to analyze such issues in a comprehensive manner by exploring practices, rules, and researcher opinions regarding proxy consent, minor assent, specimens......-mail to a selected group of researchers dealing with pediatric biobanking (n=57). Returned questionnaires (n=31) highlighted that the collection, storage, distribution, and use of biospecimens and data from children were widely practiced in the contacted laboratories. In most cases, pediatric biobanking...

  3. Investigating clinical predictors of arteriovenous fistula functional patency in a European cohort.

    Science.gov (United States)

    Masengu, Agnes; Maxwell, Alexander P; Hanko, Jennifer B

    2016-02-01

    Arteriovenous fistula (AVF) failure to mature (FTM) rates contribute to excessive dependence on central venous catheters for haemodialysis. Choosing the most appropriate vascular access site for an individual patient is guided largely by their age, co-morbidities and clinical examination. We investigated the clinical predictors of AVF FTM in a European cohort of patients and applied an existing clinical risk prediction model for AVF FTM to this population. A prospective cohort study was designed that included all patients undergoing AVF creation between January 2009 and December 2014 in a single centre (Belfast City Hospital) who had a functional AVF outcome observed by March 2015. A total of 525 patients had a functional AVF outcome recorded and were included in the FTM analysis. In this cohort, 309 (59%) patients achieved functional AVF patency and 216 (41%) patients had FTM. Female gender [P functional patency and ultimately survival in dialysis patients. Clinical predictors of AVF FTM may not be sufficient on their own to improve vascular access functional patency rates.

  4. Environmental occurrence and clinical impact of Vibrio vulnificus and Vibrio parahaemolyticus: a European perspective.

    Science.gov (United States)

    Baker-Austin, Craig; Stockley, Louise; Rangdale, Rachel; Martinez-Urtaza, Jaime

    2010-02-01

    Vibrio vulnificus and Vibrio parahaemolyticus are ubiquitous Gram-negative bacterial pathogens found naturally in marine and estuarine waters, and are a leading cause of seafood-associated bacterial illness. These pathogens are commonly reported in the USA and in many Asian countries, including China, Japan and Taiwan; however, there is growing concern that V. vulnificus and V. parahaemolyticus may represent an important and increasing clinical problem in Europe. Several factors underlie the need for a greater understanding of these non-cholera vibrios within a European context. First, there is a growing body of evidence to suggest that V. vulnificus and V. parahaemolyticus infections are increasing, and tend to follow regional climatic trends, with outbreaks typically following episodes of unusually warm weather. Such findings are especially alarming given current predictions regarding warming of marine waters as a result of global climatic change. Second, a myriad of epidemiological factors may greatly increase the incidence as well as clinical burden of these pathogens - including increasing global consumption and trade of seafood produce coupled to an increase in the number of susceptible individuals consuming seafood produce. Finally, there is currently a lack of detailed surveillance information regarding non-cholerae Vibrio infections in Europe, as these pathogens are not notifiable in many countries, which probably masks the true clinical burden of many human infections. This review will present a pertinent overview of both the environmental occurrence and clinical impact of V. vulnificus and V. parahaemolyticus in Europe. © 2010 Crown copyright.

  5. Community participation in clinical health research - a new research ...

    African Journals Online (AJOL)

    The idea of community participation in health and research can be found in all major international and national declarations, including South Africa. Researchers are no longer perceived as having the right to exercise monopoly on conducting and explaining their research, but are perceived to have a duty to empower the ...

  6. European Neutrons form Parasitic Research to Global Strategy: Realizing Plans for a Transnational European Spallation Source in the Wake of the Cold War

    Science.gov (United States)

    Kaiserfeld, Thomas

    2016-03-01

    Studies of Big Science have early on focused on instrumentation and scientific co-operation in large organizations, later on to take into account symbolic values and specific research styles while more recently also involving the relevance of commercial interests and economic development as well as the assimilation of research traditions. In accordance with these transformed practices, this presentation will analyze how an organization with the purpose of realizing a Big-Science facility, The European Spallation Source, has successfully managed to present the project as relevant to different national and international policy-makers, to the community of European neutron researchers as well as to different industrial interests. All this has been achieved in a research-policy environment, which has been the subject to drastic transformations, from calls to engage researchers from the former eastern bloc in the early 1990s via competition with American and Asian researchers at the turn of the century 2000 to intensified demands on business applications. During this process, there has also been fierce competition between different potential sites in the U.K., Germany, Spain, Hungary and Sweden, not once, but twice. The project has in addition been plagued by withdrawals of key actors as well as challenging problems in the field of spallation-source construction. Nevertheless, the European Spallation Source has survived from the early 1990s until today, now initiating the construction process at Lund in southern Sweden. In this presentation, the different measures taken and arguments raised by the European Spallation Source project in order to realize the facility will be analysed. Especially the different designs of the European Spallation Source will be analysed as responses to external demands and threats.

  7. Clinical research training of Peruvian neurologists: a baseline assessment

    Directory of Open Access Journals (Sweden)

    Joseph Raymond Zunt

    2010-06-01

    Full Text Available In Peru, despite a strong clinical research infrastructure in Lima, and Masters degree programs in epidemiology at three universities, few neurologists participate in clinical research. It was our objective to identify perceived needs and opportunities for increasing clinical research capacity and training opportunities for Peruvian neurologists. We conducted a descriptive, cross-sectional survey of Peruvian neurologists in Lima and Arequipa, Peru. Forty-eight neurologists completed written surveys and oral interviews. All neurologists reported interest in clinical research, but noted that lack of time and financial resources limited their ability to participate. Although most neurologists had received some training in epidemiology and research design as medical students or residents, the majority felt these topics were not adequately covered. Neurologists in Arequipa noted international funding for clinical research was uncommon outside the capital city of Lima. We concluded that clinical research is important to Peruvian neurologists. The three main barriers to increased participation in clinical research identified by neurologists were insufficient training in clinical research methodology, meager funding opportunities, and lack of dedicated time to participate in clinical research. Distance learning holds promise as a method for providing additional training in clinical research methodology, especially for neurologists who may have difficulty traveling to larger cities for additional training.

  8. The Situation of the Female Workforce in the Field of Scientific Research in European Countries

    Directory of Open Access Journals (Sweden)

    CRISTINA LEOVARIDIS

    2010-04-01

    Full Text Available This study aims at identifying if and to what extent we can speak of the existence of gender imbalances in the field of scientific research in the European Union as a whole, but also comparatively between different countries, including the situation in Romania. After a short overview of the context in which this preoccupation appeared in European gender studies and of the possible causes which can determine this imbalance, the paper continues with a presentation of the general situation of the female/male workforce in the member states, followed by a analysis of the educational levels of women compared with men, with respect to stages of education. The study also analyzes the data on the participation of women in the field of scientific research from the point of view of share of the total, broken down by sectors of activity and scientific fields. A related focus is the participation of women in the field of higher education, according to hierarchical levels, from the perspective of access to research financing, of expenses per researchers, etc., focusing on the gender imbalances pointed out earlier and on the specificity of former communist countries.

  9. Gas Cooled Fast Reactor Research and Development in the European Union

    Directory of Open Access Journals (Sweden)

    Richard Stainsby

    2009-01-01

    Full Text Available Gas-cooled fast reactor (GFR research is directed towards fulfilling the ambitious goals of Generation IV (Gen IV, that is, to develop a safe, sustainable, reliable, proliferation-resistant and economic nuclear energy system. The research is directed towards developing the GFR as an economic electricity generator, with good safety and sustainability characteristics. Fast reactors maximise the usefulness of uranium resources by breeding plutonium and can contribute to minimising both the quantity and radiotoxicity nuclear waste by actinide transmutation in a closed fuel cycle. Transmutation is particularly effective in the GFR core owing to its inherently hard neutron spectrum. Further, GFR is suitable for hydrogen production and process heat applications through its high core outlet temperature. As such GFR can inherit the non-electricity applications that will be developed for thermal high temperature reactors in a sustainable manner. The Euratom organisation provides a route by which researchers in all European states, and other non-European affiliates, can contribute to the Gen IV GFR system. This paper summarises the achievements of Euratom's research into the GFR system, starting with the 5th Framework programme (FP5 GCFR project in 2000, through FP6 (2005 to 2009 and looking ahead to the proposed activities within the 7th Framework Programme (FP7.

  10. Hereditary Colorectal Cancer Syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the Familial Risk–Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guidelines

    Science.gov (United States)

    Stoffel, Elena M.; Mangu, Pamela B.; Gruber, Stephen B.; Hamilton, Stanley R.; Kalady, Matthew F.; Lau, Michelle Wan Yee; Lu, Karen H.; Roach, Nancy; Limburg, Paul J.

    2015-01-01

    Purpose To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC) syndromes. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The Familial Risk–Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guideline published in 2013 on behalf of the European Society for Medical Oncology (ESMO) Guidelines Working Group in Annals of Oncology was reviewed for developmental rigor by methodologists, with content and recommendations reviewed by an ASCO endorsement panel. Results The ASCO endorsement panel determined that the recommendations of the ESMO guidelines are clear, thorough, and based on the most relevant scientific evidence. The ASCO panel endorsed the ESMO guidelines and added a few qualifying statements. Recommendations Approximately 5% to 6% of patient cases of CRC are associated with germline mutations that confer an inherited predisposition for cancer. The possibility of a hereditary cancer syndrome should be assessed for every patient at the time of CRC diagnosis. A diagnosis of Lynch syndrome, familial adenomatous polyposis, or another genetic syndrome can influence clinical management for patients with CRC and their family members. Screening for hereditary cancer syndromes in patients with CRC should include review of personal and family histories and testing of tumors for DNA mismatch repair deficiency and/or microsatellite instability. Formal genetic evaluation is recommended for individuals who meet defined criteria. PMID:25452455

  11. "Innovation and Intellectual Property Policies in European Research Infrastructure Consortia - PART I: The Case of the European Spallation Source ERIC"

    DEFF Research Database (Denmark)

    Yu, Helen; Wested, Jakob; Minssen, Timo

    2017-01-01

    , the European Spallation Source ERIC is required to adopt various policy documents relating to the operation and management of the facility. These cover a wide variety of issues such as user access, public procurement, intellectual property rights (IPR), data management, and dissemination. One of the main goals...

  12. Prostate Cancer Clinical Consortium Clinical Research Site: Targeted Therapies

    Science.gov (United States)

    2016-10-01

    a multi-institutional infrastructure incorporating 5 leading prostate cancer clinical sites, 2 sequencing and computational analysis sites, linked...unacceptable toxicity. Radiological assesment were defined according PCWG2 criteria and RECIST 1.1. Results: 64 pts were identified, 47 met all criteria

  13. Future European health care: cost containment, health care reform and scientific progress in drug research.

    Science.gov (United States)

    Emilien, G

    1997-01-01

    The cost of the development of a new pharmaceutical product from its conception and synthesis through to the regulatory approval process has more than quadrupled in the last 20 years. Both clinical and total development times have increased substantially. To amortize the costs incurred, the pharmaceutical industry has taken an international dimension. The incentives for pharmaceutical firms to discover and develop new drugs depend on the length of the development and regulatory review process plus the potential market size. Recent regulatory, economic and political changes may have significant implications for the future of new drug developments in Europe. The European Union industrial policy felt that there is a need for convergence in the area of pricing. It is recommended that the policy should aim to contain growth in pharmaceutical expenses by means specific to reimbursement rather than direct price controls. By encouraging doctors to prescribe and customers to use generics, competition is enhanced to bring down drug prices. More emphasis is being laid by government in educating customers to cost-awareness and cost-benefit ratios with regard to pharmaceuticals. Concerning clinical trials, European harmonization has been achieved by significant developments: the rights and integrity of the trial subjects are protected; the credibility of the data is established; and the ethical, scientific and technical quality of the trials has improved. Future European health care forecasts a whole change in the pharmaceutical business. Important issues in cost and outcome measurement should be carefully planned and considered in drug development. Due to important mergers and acquisitions, the pharmaceutical sector will consist mainly of important multinational corporations. In this way, valuable new products may be brought to the market.

  14. CPTAC | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics.

  15. Assessing research participants' perceptions of their clinical research experiences.

    Science.gov (United States)

    Kost, Rhonda G; Lee, Laura M; Yessis, Jennifer; Coller, Barry S; Henderson, David K

    2011-12-01

    Participants' perceptions of their research experiences provide valuable measures of ethical treatment, yet no validated instruments exist to measure these experiences. We conducted focus groups of research participants and professionals as the initial step in developing a validated instrument. Research participants enrolled in 12 focus groups, consisting of: (1) individuals with disorders undergoing interventions; (2) in natural history studies; or (3) healthy volunteers. Research professionals participated in six separate groups of: (1) institutional review board members, ethicists, and Research Subject Advocates; (2) research nurses/coordinators; or (3) investigators. Focus groups used standard methodologies. Eighty-five participants and 29 professionals enrolled at eight academic centers. Altruism and personal relevance of the research were commonly identified motivators; financial compensation was less commonly mentioned. Participants were satisfied with informed consent processes but disappointed if not provided test results, or study outcomes. Positive relationships with research teams were valued highly. Research professionals were concerned about risks, undue influence, and informed consent. Participants join studies for varied, complex reasons, notably altruism and personal relevance. They value staff relationships, health gains, new knowledge, and compensation, and expect professionalism and good organization. On the basis of these insights, we propose specific actions to enhance participant recruitment, retention, and satisfaction. © 2011 Wiley Periodicals, Inc.

  16. Assessing Research Participants’ Perceptions of their Clinical Research Experiences

    Science.gov (United States)

    Kost, Rhonda G.; Lee, Laura M.; Yessis, Jennifer; Coller, Barry S.; Henderson, David K.

    2011-01-01

    Abstract Introduction: Participants’ perceptions of their research experiences provide valuable measures of ethical treatment, yet no validated instruments exist to measure these experiences. We conducted focus groups of research participants and professionals as the initial step in developing a validated instrument. Methods: Research participants enrolled in 12 focus groups, consisting of: (1) individuals with disorders undergoing interventions; (2) in natural history studies; or (3) healthy volunteers. Research professionals participated in six separate groups of: (1) institutional review board members, ethicists, and Research Subject Advocates; (2) research nurses/coordinators; or (3) investigators. Focus groups used standard methodologies. Results: Eighty‐five participants and 29 professionals enrolled at eight academic centers. Altruism and personal relevance of the research were commonly identified motivators; financial compensation was less commonly mentioned. Participants were satisfied with informed consent processes but disappointed if not provided test results, or study outcomes. Positive relationships with research teams were valued highly. Research professionals were concerned about risks, undue influence, and informed consent. Conclusions: Participants join studies for varied, complex reasons, notably altruism and personal relevance. They value staff relationships, health gains, new knowledge, and compensation, and expect professionalism and good organization. On the basis of these insights, we propose specific actions to enhance participant recruitment, retention, and satisfaction. Clin Trans Sci 2011; Volume 4: 403–413 PMID:22212221

  17. The European Commissioner for Science and Research, Janez Potocnik, visited CERN on Tuesday 31 January

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    The European Commissioner for Science and Research, Janez Potocnik, visited the hall for testing the LHC magnets accompanied by Philippe Lebrun AT Department Leader and Robert Aymar, Director-General of CERN.

  18. European seismological data exchange, access and processing: current status of the Research Infrastructure project NERIES

    Science.gov (United States)

    Giardini, D.; van Eck, T.; Bossu, R.; Wiemer, S.

    2009-04-01

    The EC Research infrastructure project NERIES, an Integrated Infrastructure Initiative in seismology for 2006-2010 has passed its mid-term point. We will present a short concise overview of the current state of the project, established cooperation with other European and global projects and the planning for the last year of the project. Earthquake data archiving and access within Europe has dramatically improved during the last two years. This concerns earthquake parameters, digital broadband and acceleration waveforms and historical data. The Virtual European Broadband Seismic Network (VEBSN) consists currently of more then 300 stations. A new distributed data archive concept, the European Integrated Waveform Data Archive (EIDA), has been implemented in Europe connecting the larger European seismological waveform data. Global standards for earthquake parameter data (QuakeML) and tomography models have been developed and are being established. Web application technology has been and is being developed to make a jump start to the next generation data services. A NERIES data portal provides a number of services testing the potential capacities of new open-source web technologies. Data application tools like shakemaps, lossmaps, site response estimation and tools for data processing and visualisation are currently available, although some of these tools are still in an alpha version. A European tomography reference model will be discussed at a special workshop in June 2009. Shakemaps, coherent with the NEIC application, are implemented in, among others, Turkey, Italy, Romania, Switzerland, several countries. The comprehensive site response software is being distributed and used both inside and outside the project. NERIES organises several workshops inviting both consortium and non-consortium participants and covering a wide range of subjects: ‘Seismological observatory operation tools', ‘Tomography', ‘Ocean bottom observatories', 'Site response software training

  19. European AIDS Clinical Society Second Standard of Care Meeting, Brussels 16-17 November 2016

    DEFF Research Database (Denmark)

    De Wit, S; Battegay, M; D'Arminio Monforte, A

    2017-01-01

    The European AIDS Clinical Society (EACS) organized a second meeting on Standard of Care in Europe on November 16-17 th, 2016. The aims of the meeting were to discuss and propose actions on three topics, namely: Adherence to guidelines for treatment initiation, treatment monitoring and outcomes......, Retention in care and HIV and tuberculosis co-infection. Several actions need to be implemented in order to further improve quality of care and treatment of HIV in Europe. A common ground for standard of care, based on the EACS Guidelines should be established throughout Europe. EACS plans to interact....... Improving integration of services and accessibility to care play a major role. Integration is also key for optimizing care of HIV-tuberculosis co-infection, as well as diagnosis and prevention of tuberculosis in population at risk. The Standard of Care meeting organized every other year by EACS provides...

  20. The European general practice research network presents the translations of its comprehensive definition of multimorbidity in family medicine in ten European languages.

    Science.gov (United States)

    Le Reste, Jean Yves; Nabbe, Patrice; Rivet, Charles; Lygidakis, Charilaos; Doerr, Christa; Czachowski, Slawomir; Lingner, Heidrun; Argyriadou, Stella; Lazic, Djurdjica; Assenova, Radost; Hasaganic, Melida; Munoz, Miquel Angel; Thulesius, Hans; Le Floch, Bernard; Derriennic, Jeremy; Sowinska, Agnieska; Van Marwijk, Harm; Lietard, Claire; Van Royen, Paul

    2015-01-01

    Multimorbidity, according to the World Health Organization, exists when there are two or more chronic conditions in one patient. This definition seems inaccurate for the holistic approach to Family Medicine (FM) and long-term care. To avoid this pitfall the European General Practitioners Research Network (EGPRN) designed a comprehensive definition of multimorbidity using a systematic literature review. To translate that English definition into European languages and to validate the semantic, conceptual and cultural homogeneity of the translations for further research. Forward translation of the EGPRN's definition of multimorbidity followed by a Delphi consensus procedure assessment, a backward translation and a cultural check with all teams to ensure the homogeneity of the translations in their national context. Consensus was defined as 70% of the scores being higher than 6. Delphi rounds were repeated in each country until a consensus was reached. 229 European medical expert FPs participated in the study. Ten consensual translations of the EGPRN comprehensive definition of multimorbidity were achieved. A comprehensive definition of multimorbidity is now available in English and ten European languages for further collaborative research in FM and long-term care.

  1. The European General Practice Research Network Presents the Translations of Its Comprehensive Definition of Multimorbidity in Family Medicine in Ten European Languages

    Science.gov (United States)

    Le Reste, Jean Yves; Nabbe, Patrice; Rivet, Charles; Lygidakis, Charilaos; Doerr, Christa; Czachowski, Slawomir; Lingner, Heidrun; Argyriadou, Stella; Lazic, Djurdjica; Assenova, Radost; Hasaganic, Melida; Munoz, Miquel Angel; Thulesius, Hans; Le Floch, Bernard; Derriennic, Jeremy; Sowinska, Agnieska; Van Marwijk, Harm; Lietard, Claire; Van Royen, Paul

    2015-01-01

    Background Multimorbidity, according to the World Health Organization, exists when there are two or more chronic conditions in one patient. This definition seems inaccurate for the holistic approach to Family Medicine (FM) and long-term care. To avoid this pitfall the European General Practitioners Research Network (EGPRN) designed a comprehensive definition of multimorbidity using a systematic literature review. Objective To translate that English definition into European languages and to validate the semantic, conceptual and cultural homogeneity of the translations for further research. Method Forward translation of the EGPRN’s definition of multimorbidity followed by a Delphi consensus procedure assessment, a backward translation and a cultural check with all teams to ensure the homogeneity of the translations in their national context. Consensus was defined as 70% of the scores being higher than 6. Delphi rounds were repeated in each country until a consensus was reached Results 229 European medical expert FPs participated in the study. Ten consensual translations of the EGPRN comprehensive definition of multimorbidity were achieved. Conclusion A comprehensive definition of multimorbidity is now available in English and ten European languages for further collaborative research in FM and long-term care. PMID:25607642

  2. A RESEARCH OF E-BOOK MARKET TRENDS: NORTH AMERICA AND THE EUROPEAN COMMUNITY

    OpenAIRE

    Andreja Zubac; Andreja Tominac

    2014-01-01

    AbstractPurpose: The aim of this paper is to provide an overview of research on the presence of the electronic book on the book market, its trends and developments as well as point towards the difficulties faced by all professions related to it in the countries of the European Community.Methodology / approach: This paper analyzes the domestic and foreign literature and explores the websites of companies that operate with e-books in order to get an overview of the actual state of business oper...

  3. EISCAT_3D: the European three-dimensional imaging radar for atmospheric and geospace research

    Science.gov (United States)

    Ulich, Thomas; Aikio, Anita; McCrea, Ian; Turunen, Esa

    The EISCAT Scientific Association operates three incoherent scatter radars in Tromsø (Norway) and on Svalbard. The UHF radar, which operates at 930 MHz, is the only tristatic incoherent scatter radar in the world. The transmitter is located in Tromsø and additional receiver sites are in Kiruna (Sweden) and Sodankylü (Finland). However, due to interferences with mobile a communication, tristatic operation will come to an end in due time. In the future, EISCAT will build the next generation incoherent scatter radar, which will provide comprehensive 3D monitoring of the atmosphere and ionosphere above Northern Fenno-Scandinavia. The EISCAT 3D radar system will consist of multiple phased arrays, using the latest digital signal processing to achieve ten times higher temporal and spatial resolution than the present radars. The European Strategy Forum on Research Infrastructures (ESFRI) selected EISCAT 3D for the Roadmap 2008 for Large-Scale European Research Infrastructures for the next 20-30 years. The facility will be constructed as a modular system by 2015. EISCAT 3D will be a volumetric radar capable of imaging an extended spatial area with simul-taneous full-vector drift velocities, having continuous operation modes, short baseline interfer-ometry capability for imaging sub-beamwidth scales, real-time data access for applications and extensive data archiving facilities. The design of the antenna arrays will be modular at different scales allowing for mass-production of the components. Some arrays will be very large, in the scale of 32,000 individual antenna elements. The receiver arrays will be located at 50-150 km distance from the illuminators, and some smaller arrays closer by to support continuous interferometric observations. The total system will comprise 100,000 elements. The actual radar sites have to be carefully chosen. This new large-scale European research infrastructure has applications in a wide range of Eu-ropean research areas including Earth

  4. Mission Specific Platforms: Past achievements and future developments in European led ocean research drilling.

    Science.gov (United States)

    Cotterill, Carol; McInroy, David; Stevenson, Alan

    2013-04-01

    Mission Specific Platform (MSP) expeditions are operated by the European Consortium for Ocean Research Drilling (ECORD). Each MSP expedition is unique within the Integrated Ocean Drilling Program (IODP). In order to complement the abilities of the JOIDES Resolution and the Chikyu, the ECORD Science Operator (ESO) must source vessels and technology suitable for each MSP proposal on a case-by-case basis. The result is that ESO can meet scientific requirements in a flexible manner, whilst maintaining the measurements required for the IODP legacy programme. The process of tendering within EU journals for vessels and technology means that the planning process for each MSP Expedition starts many years in advance of the operational phase. Involvement of proposal proponents from this early stage often leads to the recognition for technological research and development to best meet the scientific aims and objectives. One example of this is the planning for the Atlantis Massif proposal, with collaborative development between the British Geological Survey (BGS) and MARUM, University of Bremen, on suitable instruments for seabed drills, with the European Petrophysics Consortium (EPC) driving the development of suitable wireline logging tools that can be used in association with such seabed systems. Other technological developments being undertaken within the European IODP community include in-situ pressure sampling for gas hydrate expeditions, deep biosphere and fluid sampling equipment and CORK technology. This multi-national collaborative approach is also employed by ESO in the operational phase. IODP Expedition 302 ACEX saw vessel and ice management support from Russia and Sweden to facilitate the first drilling undertaken in Arctic sea ice. A review of MSP expeditions past, present and future reveal the significant impact of European led operations and scientific research within the current IODP programme, and also looking forward to the start of the new International

  5. Food-related life styles in Singapore: Testing a Western European research instrument in Southeast Asia

    DEFF Research Database (Denmark)

    Askegaard, Søren; Brunsø, Karen; Crippen, Kaye

    The food-related life style instrument developed by the MAPP research group has, up til now, been applied mainly in the context of European cultures. The purpose of the present study is to apply the food-related life style instrument in a new and very different cultural setting, to compare results......, and to interpret similarities and differences found. For this purpose, data have been collected in Singaporean families using the food-related life style instrument. A total of 89 questionnaires form the basis of the analysis. First, the cross-cultural validity of the instrument is tested, and secondly...

  6. Ensuring rigour and trustworthiness of qualitative research in clinical pharmacy.

    Science.gov (United States)

    Hadi, Muhammad Abdul; José Closs, S

    2016-06-01

    The use of qualitative research methodology is well established for data generation within healthcare research generally and clinical pharmacy research specifically. In the past, qualitative research methodology has been criticized for lacking rigour, transparency, justification of data collection and analysis methods being used, and hence the integrity of findings. Demonstrating rigour in qualitative studies is essential so that the research findings have the "integrity" to make an impact on practice, policy or both. Unlike other healthcare disciplines, the issue of "quality" of qualitative research has not been discussed much in the clinical pharmacy discipline. The aim of this paper is to highlight the importance of rigour in qualitative research, present different philosophical standpoints on the issue of quality in qualitative research and to discuss briefly strategies to ensure rigour in qualitative research. Finally, a mini review of recent research is presented to illustrate the strategies reported by clinical pharmacy researchers to ensure rigour in their qualitative research studies.

  7. Conducting research in clinical psychology practice: Barriers, facilitators, and recommendations.

    Science.gov (United States)

    Smith, Kirsten V; Thew, Graham R

    2017-09-01

    The combination of clinical psychologists' therapeutic expertise and research training means that they are in an ideal position to be conducting high-quality research projects. However, despite these skills and the documented benefits of research to services and service users, research activity in practice remains low. This article aims to give an overview of the advantages of, and difficulties in conducting research in clinical practice. We reviewed the relevant literature on barriers to research and reflected on our clinical and research experiences in a range of contexts to offer practical recommendations. We considered factors involved in the planning, sourcing support, implementation, and dissemination phases of research, and outline suggestions to improve the feasibility of research projects in post-qualification roles. We suggest that research leadership is particularly important within clinical psychology to ensure the profession's continued visibility and influence within health settings. Clinical implications Emerging evidence suggests that clinical settings that foster research are associated with better patient outcomes. Suggestions to increase the feasibility of research projects in clinical settings are detailed. Limitations The present recommendations are drawn from the authors' practical experience and may need adaptation to individual practitioners' settings. This study does not attempt to assess the efficacy of the strategies suggested. © 2017 The Authors. British Journal of Clinical Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

  8. Highly effective cystic fibrosis clinical research teams: critical success factors.

    Science.gov (United States)

    Retsch-Bogart, George Z; Van Dalfsen, Jill M; Marshall, Bruce C; George, Cynthia; Pilewski, Joseph M; Nelson, Eugene C; Goss, Christopher H; Ramsey, Bonnie W

    2014-08-01

    Bringing new therapies to patients with rare diseases depends in part on optimizing clinical trial conduct through efficient study start-up processes and rapid enrollment. Suboptimal execution of clinical trials in academic medical centers not only results in high cost to institutions and sponsors, but also delays the availability of new therapies. Addressing the factors that contribute to poor outcomes requires novel, systematic approaches tailored to the institution and disease under study. To use clinical trial performance metrics data analysis to select high-performing cystic fibrosis (CF) clinical research teams and then identify factors contributing to their success. Mixed-methods research, including semi-structured qualitative interviews of high-performing research teams. CF research teams at nine clinical centers from the CF Foundation Therapeutics Development Network. Survey of site characteristics, direct observation of team meetings and facilities, and semi-structured interviews with clinical research team members and institutional program managers and leaders in clinical research. Critical success factors noted at all nine high-performing centers were: 1) strong leadership, 2) established and effective communication within the research team and with the clinical care team, and 3) adequate staff. Other frequent characteristics included a mature culture of research, customer service orientation in interactions with study participants, shared efficient processes, continuous process improvement activities, and a businesslike approach to clinical research. Clinical research metrics allowed identification of high-performing clinical research teams. Site visits identified several critical factors leading to highly successful teams that may help other clinical research teams improve clinical trial performance.

  9. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences

    Science.gov (United States)

    National Academies Press, 2011

    2011-01-01

    Comprehensive research and a highly-trained workforce are essential for the improvement of health and health care both nationally and internationally. During the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various…

  10. European Social Work Research Association SIG to Study Decisions, Assessment, and Risk.

    Science.gov (United States)

    Taylor, Brian; Killick, Campbell; Bertotti, Teresa; Enosh, Guy; Gautschi, Joel; Hietamäki, Johanna; Sicora, Alessandro; Whittaker, Andrew

    2017-12-13

    The increasing interest in professional judgement and decision making is often separate from the discourse about "risk," and the time-honored focus on assessment. The need to develop research in and across these topics was recognized in the founding of a Decisions, Assessment, and Risk Special Interest Group (DARSIG) by the European Social Work Research Association in 2014. The Group's interests include cognitive judgements; decision processes with clients, families, other professionals and courts; assessment tools and processes; the assessment, communication, and management of risk; and legal, ethical, and emotional aspects of these. This article outlines the founding and scope of DARSIG; gives an overview of decision making, assessment, and risk for practice; illustrates connections between these; and highlights future research directions. Professional knowledge about decision making, assessment, and risk complements knowledge about effectiveness of interventions. DARSIG promises to be a useful mechanism for the purpose.

  11. Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey

    Science.gov (United States)

    McKeag, David; Lane, Carol; Lazarus, John H; Baldeschi, Lelio; Boboridis, Kostas; Dickinson, A Jane; Hullo, A Iain; Kahaly, George; Krassas, Gerry; Marcocci, Claudio; Marinò, Michele; Mourits, Maarten P; Nardi, Marco; Neoh, Christopher; Orgiazzi, Jacques; Perros, Petros; Pinchera, Aldo; Pitz, Susanne; Prummel, Mark F; Sartini, Maria S; Wiersinga, Wilmar M

    2007-01-01

    Background This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe. Methods Forty seven patients with DON presented to seven European centres during one year. Local protocols for thyroid status, ophthalmic examination and further investigation were used. Each eye was classified as having definite, equivocal, or no DON. Results Graves' hyperthyroidism occurred in the majority; 20% had received radioiodine. Of 94 eyes, 55 had definite and 17 equivocal DON. Median Clinical Activity Score was 4/7 but 25% scored 3 or less, indicating severe inflammation was not essential. Best corrected visual acuity was 6/9 (Snellen) or worse in 75% of DON eyes. Colour vision was reduced in 33 eyes, of which all but one had DON. Half of the DON eyes had normal optic disc appearance. In DON eyes proptosis was > 21 mm (significant) in 66% and visual fields abnormal in 71%. Orbital imaging showed apical muscle crowding in 88% of DON patients. Optic nerve stretch and fat prolapse were infrequently reported. Conclusion Patients with DON may not have severe proptosis and orbital inflammation. Optic disc swelling, impaired colour vision and radiological evidence of apical optic nerve compression are the most useful clinical features in this series. PMID:17035276

  12. Key Steps in Conducting Systematic Reviews for Underpinning Clinical Practice Guidelines: Methodology of the European Association of Urology.

    Science.gov (United States)

    Knoll, Thomas; Omar, Muhammad Imran; Maclennan, Steven; Hernández, Virginia; Canfield, Steven; Yuan, Yuhong; Bruins, Max; Marconi, Lorenzo; Van Poppel, Hein; N'Dow, James; Sylvester, Richard

    2017-09-13

    The findings of systematic reviews (SRs) and meta-analyses (MAs) are used for clinical decision making. The European Association of Urology has committed increasing resources into the development of high quality clinical guidelines based on such SRs and MAs. In this paper, we have summarised the process of conducting SRs for underpinning clinical practice guidelines under the auspices of the European Association of Urology Guidelines Office. The process involves explicit methods and the findings should be reproducible. When conducting a SR, the essential first step is to formulate a clear and answerable research question. An extensive literature search lays the foundation for evidence synthesis. Data are extracted independently by two reviewers and any disagreements are resolved by discussion or arbitration by a third reviewer. In SRs, data for particular outcomes in individual randomised controlled trials may be combined statistically in a meta-analysis to increase power when the studies are similar enough. Biases in studies included in a SR/MA can lead to either an over estimation or an under estimation of true intervention effect size, resulting in heterogeneity in outcome between studies. A number of different tools are available such as Cochrane Risk of Bias assessment tool for randomised controlled trials. In circumstances where there is too much heterogeneity, or when a review has included nonrandomised comparative studies, it is more appropriate to conduct a narrative synthesis. The GRADE tool for assessing quality of evidence strives to be a structured and transparent system, which can be applied to all evidence, regardless of quality. A SR not only identifies, evaluates, and summarises the best available evidence, but also the gaps to be targeted by future studies. SRs and MAs are integral in developing sound clinical practice guidelines and recommendations. Clinical practice guidelines should be evidence based, and systematic reviews and meta

  13. A pan-European survey of research in end-of-life cancer care.

    Science.gov (United States)

    Sigurdardottir, Katrin Ruth; Haugen, Dagny Faksvåg; Bausewein, Claudia; Higginson, Irene J; Harding, Richard; Rosland, Jan Henrik; Kaasa, Stein

    2012-01-01

    To date, there is no coordinated strategy for end-of-life (EOL) cancer care research in Europe. The PRISMA (Reflecting the Positive Diversities of European Priorities for Research and Measurement in End-of-life Care) project is aiming to develop a programme integrating research and measurement in EOL care. This survey aimed to map and describe present EOL cancer care research in Europe and to identify priorities and barriers. A questionnaire of 62 questions was developed and 201 researchers in 41 European countries were invited to complete it online in May 2009. An open invitation to participate was posted on the internet. Invited contacts in 36 countries sent 127 replies; eight additional responses came through websites. A total of 127 responses were eligible for analysis. Respondents were 69 male and 58 female, mean age 49 (28-74) years; 85% of the scientific team leaders were physicians. Seventy-one of 127 research groups were located in a teaching hospital or cancer centre. Forty-five percent of the groups had only one to five members and 28% six to ten members. Sixty-three of 92 groups reported specific funding for EOL care research. Seventy-five percent of the groups had published papers in journals with impact factor ≤ 5 in the last 3 years; 8% had published in journals with impact factor >10. Forty-four out of 90 groups reported at least one completed Ph.D. in the last 3 years. The most frequently reported active research areas were pain, assessment and measurement tools, and last days of life and quality of death. Very similar areas--last days of life and quality of death, pain, fatigue and cachexia, and assessment and measurement tools--were ranked as the most important research priorities. The most important research barriers were lack of funding, lack of time, and insufficient knowledge/expertise. Most research groups in EOL care are small. The few large groups (14%) had almost half of the reported publications, and more than half of the current Ph

  14. Altruism in clinical research: coordinators' orientation to their professional roles.

    Science.gov (United States)

    Fisher, Jill A; Kalbaugh, Corey A

    2012-01-01

    Research coordinators have significant responsibilities in clinical trials that often require them to find unique ways to manage their jobs, thus reshaping their professional identities. The purpose of this study was to identify how research coordinators manage role and ethical conflicts within clinical research trials. A qualitative study combining observation and 63 semistructured interviews at 25 research organizations was used. Altruism is a recurring theme in how research coordinators define and view their work. Altruism is adopted by research coordinators to: (1) Teach patient-subjects the appropriate reasons to participate in clinical research, (2) minimize the conflict between research and care, and (3) contest the undervaluation of coordinating. Altruism is a strategy used to handle the various conflicts they experience in a difficult job, and it has become part of the professional identity of clinical research coordinators. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Altruism in Clinical Research: Coordinators’ Orientation to their Professional Roles

    Science.gov (United States)

    Fisher, Jill A.; Kalbaugh, Corey A.

    2011-01-01

    Background Research coordinators have significant responsibilities in clinical trials that often require them to find unique ways to manage their jobs, thus re-shaping their professional identities. Purpose The purpose of this study is to identify how research coordinators manage role and ethical conflicts within clinical research trials. Method A qualitative study combining observation and 63 semi-structured interviews at 25 research organizations was used. Discussion Altruism is a recurring theme in how research coordinators define and view their work. Conclusion Altruism is adopted by research coordinators: 1) to teach patient-subjects the appropriate reasons to participate in clinical research, 2) to minimize the conflict between research and care, and 3) to contest the undervaluation of coordinating. Altruism is a strategy employed to handle the various conflicts they experience in a difficult job, and it has become part of the professional identity of clinical research coordinators. PMID:22083045

  16. Genetics in clinical practice: general practitioners' educational priorities in European countries.

    NARCIS (Netherlands)

    Julian-Reynier, C.; Nippert, I.; Calefato, J.M.; Harris, H.J.; Kristoffersson, U.; Schmidtke, J.; Kate, L. ten; Anionwu, E.; Benjamin, C.; Challen, K.; Plass, A.M.; Harris, R.

    2008-01-01

    Purpose: To assess how general practitioners (GPs) from European countries prioritized their genetic educational needs according to their geographic, sociodemographic, and educational characteristics. Methods: Cross-sectional survey, random and total samples of GPs in five European countries

  17. International Partnerships for Clinical Cancer Research

    Science.gov (United States)

    CGH co-sponsors the 2015 International Symposium on Cancer Clinical Trials and related meetings held in partnership with the Japanese National Cancer Center (JNCC) and Embassies of France, Korea, United Kingdom (UK), and United States (US) in Tokyo on May 14 - 15, 2015.

  18. Clinical indications for computed tomographic colonography: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline

    Energy Technology Data Exchange (ETDEWEB)

    Spada, Cristiano; Barbaro, Federico; Petruzziello, Lucio [Catholic University, Digestive Endoscopy Unit, Rome (Italy); Stoker, Jaap; Haan, Margriet C. de [University of Amsterdam, Department of Radiology, Academic Medical Center, Amsterdam (Netherlands); Alarcon, Onofre [Universidad de La Laguna, Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, La Laguna, Tenerife (Spain); Bellini, Davide; Laghi, Andrea [Sapienza University of Rome, I.C.O.T. Hospital, Department of Radiological Sciences, Oncology and Pathology, Latina (Italy); Bretthauer, Michael [Oslo University Hospital, Department of Health Economy and Health Management, University of Oslo, and Department of Transplantation Medicine, Gastroenterology Unit, Oslo (Norway); Dumonceau, Jean-Marc [Gedyt Endoscopy Center, Buenos Aires (Argentina); Ferlitsch, Monika [Medical University of Vienna, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Vienna (Austria); Halligan, Steve; Helbren, Emma; Plumb, Andrew; Taylor, Stuart A. [University College London, Centre for Medical Imaging, London (United Kingdom); Hellstrom, Mikael [Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Department of Radiology, Gothenburg (Sweden); Kuipers, Ernst J. [Erasmus MC University Medical Center, Department of Gastroenterology and Hepatology, Rotterdam (Netherlands); Lefere, Philippe [Virtual Colonoscopy Teaching Centre, Hooglede (Belgium); AZ Delta, Roeselare (Belgium); Mang, Thomas [Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna (Austria); Neri, Emanuele [University of Pisa, Diagnostic and Interventional Radiology, Pisa (Italy); Regge, Daniele [Institute for Cancer Research and Treatment, Candiolo-Torino (Italy); Hassan, Cesare [Catholic University, Digestive Endoscopy Unit, Rome (Italy); Ospedale Nuovo Regina Margherita, Department of Gastroenterology, Rome (Italy)

    2014-10-03

    Colorectal cancer (CRC) is a major cause of morbidity and mortality [1, 2]. CRC screening by fecal occult blood testing (FOBT) has been shown to reduce CRC mortality [3, 4], and is currently used in several European countries. Colonoscopy is highly effective for detecting advanced neoplasia, and endoscopic polypectomy reduces subsequent CRCspecific incidence and mortality [5]. In Europe, colonoscopy is mainly used to investigate FOBT-positive or symptomatic patients, or as a preventive strategy in those with increased CRC risk [6]. Computed tomographic colonography (CTC) is a minimally invasive imaging technique that is highly accurate for detecting colorectal cancer (CRC) and adenomatous polyps. The technique is standardized [7], and CTC is more easily performed than barium enema. Evidence-based data suggest that CTC is the natural replacement for barium enema and a complementary rather than an alternative examination to colonoscopy. However, the clinical scenarios for which CTC is indicated remain unclear. To address this uncertainty - 20 years after the first presentation of CTC at a radiological meeting [8] - the European Society of Gastrointestinal Endoscopy (ESGE) and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) decided to produce a common guideline regarding indications for CTC in clinical practice. Technical and quality issues of CTC have been deliberately excluded from this work as these have already been discussed separately [7].

  19. Breaking the Ice: Strategies for Future European Research in the Polar Oceans - The AURORA BOREALIS Concept

    Science.gov (United States)

    Lembke-Jene, L.; Biebow, N.; Wolff-Boenisch, B.; Thiede, J.; European Research Icebreaker Consortium

    2011-12-01

    Research vessels dedicated to work in polar ice-covered waters have only rarely been built. Their history began with Fritjof Nansen's FRAM, which he used for his famous first crossing of the Arctic Ocean 1893-1896. She served as example for the first generation of polar research vessels, at their time being modern instruments planned with foresight. Ice breaker technology has developed substantially since then. However, it took almost 80 years until this technical advance also reached polar research, when the Russian AKADEMIK FEDEROV, the German POLARSTERN, the Swedish ODEN and the USCG Cutter HEALY were built. All of these house modern laboratories, are ice-breakers capable to move into the deep-Arctic during the summer time and represent the second generation of dedicated polar research vessels. Still, the increasing demand in polar marine research capacities by societies that call for action to better understand climate change, especially in the high latitudes is not matched by adequate facilities and resources. Today, no icebreaker platform exists that is permanently available to the international science community for year-round expeditions into the central Arctic Ocean or heavily ice-infested waters of the polar Southern Ocean around Antarctica. The AURORA BOREALIS concept plans for a heavy research icebreaker, which will enable polar scientists around the world to launch international research expeditions into the central Arctic Ocean and the Antarctic continental shelf seas autonomously during all seasons of the year. The European Research Icebreaker Consortium - AURORA BOREALIS (ERICON-AB) was established in 2008 to plan the scientific, governance, financial, and legal frameworks needed for the construction and operation of this first multi-nationally owned and operated research icebreaker and polar scientific drilling platform. By collaborating together and sharing common infrastructures it is envisioned that European nations make a major contribution to

  20. Improving Information Management Systems Employed in Clinical Research*

    Science.gov (United States)

    Pollak, Michael N.

    1984-01-01

    The data-handling problems associated with the administration of clinical trials of new treatments are more complex than those encountered in routine clinical practice. The reasons for this are reviewed, and various computer systems used to date (with mixed success) to aid researchers responsible for clinical trial administration are criticized. Careful analysis of clinical trial data-handling problems as perceived by the clinical researcher can lead to the design of improved computer systems capable of alleviating many of the problems commonly encountered when clinical trial data is collected and analyzed. Such systems are urgently needed as the number, size and complexity of clinical trials continue to increase. They are relatively easy to cost-justify because traditional methods of collecting and tabulating clinical trial data are amongst the most labour-intensive information-handling tasks encountered in clinical medicine. Our progress in the design and implementation of a computer system to aid in the administration of clinical trials is presented.

  1. Construction of databases: advances and significance in clinical research.

    Science.gov (United States)

    Long, Erping; Huang, Bingjie; Wang, Liming; Lin, Xiaoyu; Lin, Haotian

    2015-12-01

    Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials (RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research.

  2. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules

    DEFF Research Database (Denmark)

    Gharib, H; Papini, E; Paschke, R

    2010-01-01

    American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical...... decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes...

  3. Clinical research in primary dental care.

    Science.gov (United States)

    Heasman, P A; Macpherson, L E; Haining, S A; Breckons, M

    2015-08-28

    Many commissioning bodies for research expect that researchers will actively involve the public and patients in their projects. The National Institute for Health Research (NIHR), for example, involves members of the public in reviewing funding applications and making recommendations about research funding. The NIHR's portfolio is currently operating in 97% of NHS Trusts and this now includes research sited in primary dental care. This paper presents some case studies of these and other projects which are designed specifically for patient benefit in dental services in the community. This means there is no necessity to translate the outcomes of such research from a university or hospital base to the general population as the projects are undertaken in dental practices that provide primary dental care to (predominantly) NHS patients. The relevance of the outcomes to dental care is, therefore, likely to be of direct interest and importance to commissioners of healthcare funding in the UK who have a duty to use evidence bases for commissioning decisions.

  4. EuroStemCell: A European infrastructure for communication and engagement with stem cell research.

    Science.gov (United States)

    Barfoot, Jan; Doherty, Kate; Blackburn, C Clare

    2017-10-01

    EuroStemCell is a large and growing network of organizations and individuals focused on public engagement with stem cells and regenerative medicine - a fluid and contested domain, where scientific, political, ethical, legal and societal perspectives intersect. Rooted in the European stem cell research community, this project has developed collaborative and innovative approaches to information provision and direct and online engagement, that reflect and respond to the dynamic growth of the field itself. EuroStemCell started as the communication and outreach component of a research consortium and subsequently continued as a stand-alone engagement initiative. The involvement of established European stem cell scientists has grown year-on-year, facilitating their participation in public engagement by allowing them to make high-value contributions with broad reach. The project has now had sustained support by partners and funders for over twelve years, and thus provides a model for longevity in public engagement efforts. This paper considers the evolution of the EuroStemCell project in response to - and in dialogue with - its evolving environment. In it, we aim to reveal the mechanisms and approaches taken by EuroStemCell, such that others within the scientific community can explore these ideas and be further enabled in their own public engagement endeavours. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  5. European Union research in support of environment and health: Building scientific evidence base for policy.

    Science.gov (United States)

    Karjalainen, Tuomo; Hoeveler, Arnd; Draghia-Akli, Ruxandra

    2017-06-01

    Opinion polls show that the European Union citizens are increasingly concerned about the impact of environmental factors on their health. In order to respond and provide solid scientific evidence for the numerous policies related to the protection of human health and the environment managed at the Union level, the European Union made a substantial investment in research and innovation in the past two decades through its Framework Programmes for Research and Technological Development, including the current programme, Horizon 2020, which started in 2014. This policy review paper analysed the portfolio of forty collaborative projects relevant to environment and health, which received a total amount of around 228 million euros from the EU. It gives details on their contents and general scientific trends observed, the profiles of the participating countries and institutions, and the potential policy implications of the results obtained. The increasing knowledge base is needed to make informed policy decisions in Europe and beyond, and should be useful to many stakeholders including the scientific community and regulatory authorities. Copyright © 2017. Published by Elsevier Ltd.

  6. Bibliometric Assessment of European and Sub-Saharan African Research Output on Poverty-Related and Neglected Infectious Diseases from 2003 to 2011.

    Directory of Open Access Journals (Sweden)

    J Gabrielle Breugelmans

    2015-08-01

    Full Text Available The European & Developing Countries Clinical Trials Partnership (EDCTP is a partnership of European and sub-Saharan African countries that aims to accelerate the development of medical interventions against poverty-related diseases (PRDs. A bibliometric analysis was conducted to 1 measure research output from European and African researchers on PRDs, 2 describe collaboration patterns, and 3 assess the citation impact of clinical research funded by EDCTP.Disease-specific research publications were identified in Thomson Reuters Web of Science using search terms in titles, abstracts and keywords. Publication data, including citation counts, were extracted for 2003-2011. Analyses including output, share of global papers, normalised citation impact (NCI, and geographical distribution are presented. Data are presented as five-year moving averages. European EDCTP member countries accounted for ~33% of global research output in PRDs and sub-Saharan African countries for ~10% (2007-2011. Both regions contributed more to the global research output in malaria (43.4% and 22.2%, respectively. The overall number of PRD papers from sub-Saharan Africa increased markedly (>47% since 2003, particularly for HIV/AIDS (102% and tuberculosis (TB (81%, and principally involving Southern and East Africa. For 2007-2011, European and sub-Saharan African research collaboration on PRDs was highly cited compared with the world average (NCI in brackets: HIV/AIDS 1.62 (NCI: 1.16, TB 2.11 (NCI: 1.06, malaria 1.81 (NCI: 1.22, and neglected infectious diseases 1.34 (NCI: 0.97. The NCI of EDCTP-funded papers for 2003-2011 was exceptionally high for HIV/AIDS (3.24, TB (4.08 and HIV/TB co-infection (5.10 compared with global research benchmarks (1.14, 1.05 and 1.35, respectively.The volume and citation impact of papers from sub-Saharan Africa has increased since 2003, as has collaborative research between Europe and sub-Saharan Africa. >90% of publications from EDCTP

  7. Bibliometric Assessment of European and Sub-Saharan African Research Output on Poverty-Related and Neglected Infectious Diseases from 2003 to 2011

    Science.gov (United States)

    Gurney, Karen A.; Mgone, Charles S.

    2015-01-01

    Background The European & Developing Countries Clinical Trials Partnership (EDCTP) is a partnership of European and sub-Saharan African countries that aims to accelerate the development of medical interventions against poverty-related diseases (PRDs). A bibliometric analysis was conducted to 1) measure research output from European and African researchers on PRDs, 2) describe collaboration patterns, and 3) assess the citation impact of clinical research funded by EDCTP. Methodology/Principal Findings Disease-specific research publications were identified in Thomson Reuters Web of Science using search terms in titles, abstracts and keywords. Publication data, including citation counts, were extracted for 2003–2011. Analyses including output, share of global papers, normalised citation impact (NCI), and geographical distribution are presented. Data are presented as five-year moving averages. European EDCTP member countries accounted for ~33% of global research output in PRDs and sub-Saharan African countries for ~10% (2007–2011). Both regions contributed more to the global research output in malaria (43.4% and 22.2%, respectively). The overall number of PRD papers from sub-Saharan Africa increased markedly (>47%) since 2003, particularly for HIV/AIDS (102%) and tuberculosis (TB) (81%), and principally involving Southern and East Africa. For 2007–2011, European and sub-Saharan African research collaboration on PRDs was highly cited compared with the world average (NCI in brackets): HIV/AIDS 1.62 (NCI: 1.16), TB 2.11 (NCI: 1.06), malaria 1.81 (NCI: 1.22), and neglected infectious diseases 1.34 (NCI: 0.97). The NCI of EDCTP-funded papers for 2003–2011 was exceptionally high for HIV/AIDS (3.24), TB (4.08) and HIV/TB co-infection (5.10) compared with global research benchmarks (1.14, 1.05 and 1.35, respectively). Conclusions The volume and citation impact of papers from sub-Saharan Africa has increased since 2003, as has collaborative research between Europe and

  8. Third European Stroke Science Workshop

    NARCIS (Netherlands)

    Dichgans, Martin; Planas, Anna M.; Biessels, Geert Jan|info:eu-repo/dai/nl/165576367; van der Worp, Bart|info:eu-repo/dai/nl/189855010; Sudlow, Cathie; Norrving, B.; Lees, Kennedy; Mattle, Heinrich P.

    2016-01-01

    Lake Eibsee, Garmisch-Partenkirchen, November 19 to 21, 2015: The European Stroke Organization convened >120 stroke experts from 27 countries to discuss latest results and hot topics in clinical, translational, and basic stroke research. Since its inception in 2011, the European Stroke Science

  9. Car driver training and licensing systems in Europe : report prepared by members of Forum of European Road Safety Research Institutes FERSI and supported by European Commission Transport Directorate, DG VII.

    NARCIS (Netherlands)

    Lynam, D. & Twisk, D.A.M.

    1995-01-01

    This report describes a survey of car driver training and licensing systems in European countries, undertaken by the Forum of European Road Safety Research Institutes (FERSI) supported by the Transport Directorate of the European Union. A literature review and collation of general information on

  10. How to emerge from the conservatism in clinical research methodology?

    Science.gov (United States)

    Kotecki, Nuria; Penel, Nicolas; Awada, Ahmad

    2017-09-01

    Despite recent changes in clinical research methodology, many challenges remain in drug development methodology. Advances in molecular biology and cancer treatments have changed the clinical research landscape. Thus, we moved from empirical clinical oncology to molecular and immunological therapeutic approaches. Along with this move, adapted dose-limiting toxicities definitions, endpoints, and dose escalation methods have been proposed. Moreover, the classical frontier between phase I, phase II, and phase III has become unclear in particular for immunological approaches. So, investigators are facing major challenges in drug development methodology. We propose to individualize clinical research using innovative approaches to significantly improve patient outcomes and targeting what is considered unmet need. Integrating high level of translational research and performing well designed biomarker studies with great potential for clinical practice are of utmost importance. This could be performed within new models of clinical research networks and by building a strong collaboration between academic, cooperative groups, on-site investigators, and pharma.

  11. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology.

    Science.gov (United States)

    Muraro, A; Roberts, G; Worm, M; Bilò, M B; Brockow, K; Fernández Rivas, M; Santos, A F; Zolkipli, Z Q; Bellou, A; Beyer, K; Bindslev-Jensen, C; Cardona, V; Clark, A T; Demoly, P; Dubois, A E J; DunnGalvin, A; Eigenmann, P; Halken, S; Harada, L; Lack, G; Jutel, M; Niggemann, B; Ruëff, F; Timmermans, F; Vlieg-Boerstra, B J; Werfel, T; Dhami, S; Panesar, S; Akdis, C A; Sheikh, A

    2014-08-01

    Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide evidence-based recommendations for the recognition, risk factor assessment, and the management of patients who are at risk of, are experiencing, or have experienced anaphylaxis. While the primary audience is allergists, these guidelines are also relevant to all other healthcare professionals. The development of these guidelines has been underpinned by two systematic reviews of the literature, both on the epidemiology and on clinical management of anaphylaxis. Anaphylaxis is a potentially life-threatening condition whose clinical diagnosis is based on recognition of a constellation of presenting features. First-line treatment for anaphylaxis is intramuscular adrenaline. Useful second-line interventions may include removing the trigger where possible, calling for help, correct positioning of the patient, high-flow oxygen, intravenous fluids, inhaled short-acting bronchodilators, and nebulized adrenaline. Discharge arrangements should involve an assessment of the risk of further reactions, a management plan with an anaphylaxis emergency action plan, and, where appropriate, prescribing an adrenaline auto-injector. If an adrenaline auto-injector is prescribed, education on when and how to use the device should be provided. Specialist follow-up is essential to investigate possible triggers, to perform a comprehensive risk assessment, and to prevent future episodes by developing personalized risk reduction strategies including, where possible, commencing allergen immunotherapy. Training for the patient and all caregivers is essential. There are still many gaps in the evidence base for anaphylaxis. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Qualitative Research Methods in Visual Communication. Case Study: Visual Networks in the Promotional Videos of the European Year of Volunteering

    Directory of Open Access Journals (Sweden)

    Camelia Cmeciu

    2013-05-01

    Full Text Available European Years are a means of promoting European issues at a macro and micro-level. The objective of this paper is to provide the visual differences in the framing of the issue of volunteering at a European and national level. The approach focuses on a blending of two qualitative research methods in visual communication: ATLAS.ti (computer assisted/ aided qualitative data analysis software and social semiotics. The results of our analysis highlight two network views on volunteering promoted through videos, a salience of transactional processes in the implementation of volunteering at a European and national level, and a classification of various types of social practices specific to Romania. This study provides an insight into the way in which two different qualitative methods may be combined in order to provide a visual representation and interpretation to a European issue.

  13. Integrating research and education into clinical practice: the multi-organ transplant student research training program.

    Science.gov (United States)

    Famure, Olusegun; Li, Anna; Ross, Heather; Kim, S Joseph

    2012-01-01

    Given the increased student interest in health research and the need to implement health research initiatives, the Multi-Organ Transplant Student Research Training Program provides student trainees with the opportunity to contribute to health research initiatives in transplant care. Program quality initiatives achieved include the development of a clinical research database, knowledge exchange, performance measurement tools, and health research projects. The program promotes collaboration between academic and healthcare institutions to integrate research and education into clinical practice.

  14. Science on the net: an analysis of the websites of the European public research institutions

    Directory of Open Access Journals (Sweden)

    Laura Massoli

    2007-09-01

    Full Text Available This article introduces a study on the websites of several European public research institutions that aims at identifying the science communication model chosen and implemented online with the purpose of reaching different target publics. The analytical approach takes into account a number of indicators: from the institutional identity to the scientific features, from the interactive services to the internationalisation level, in order to evaluate whether the web provides an added value in the adopted communication model and in building a relation with the users. Lights and shades emerge from this study in which good practices side examples of a much weaker science communication approach, outlining a general context where a public research institution website has been still used as a presentation tool and its interactive opportunities have not been capitalised.

  15. The current state of midwifery and development of midwifery research in four European countries.

    Science.gov (United States)

    Luyben, Ans G; Wijnen, Hennie A A; Oblasser, Claudia; Perrenoud, Patricia; Gross, Mechthild M

    2013-05-01

    to describe the current state of midwifery and explore the development of midwifery research during the last two decades in four non-English speaking European countries in order to understand what factors influenced the course of establishing research as a professional activity. qualitative collective case study. Germany, Austria, Switzerland and the Netherlands. with the ICM Workshop in Germany in 1989 as a central starting point for midwifery research in all four countries, different courses, in timing as well as content, characterised its development in the individual countries. Major factors contributing to this development during the last decades involved the history and character of midwifery, initiatives of individual midwifery researchers, alliances with other professions and the transition of midwifery programmes into higher education. Whereas midwifery research is currently established as a professional role in all countries, future challenges involve the creation of its own profile and identity, while building up its own academic workforce and strengthening the role of midwifery in multidisciplinary alliances. although a common vision was shared between the four countries in 1989, midwifery research developed as a context-specific phenomenon related to the character of midwifery and education in each country. These factors have to be taken into account in the further development of midwifery as an academic discipline at a national as well as at an international level. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Resource use and costs of exenatide bid or insulin in clinical practice: the European CHOICE study.

    Science.gov (United States)

    Kiiskinen, Urpo; Matthaei, Stephan; Reaney, Matthew; Mathieu, Chantal; Ostenson, Claes-Göran; Krarup, Thure; Theodorakis, Michael; Kiljański, Jacek; Salaun-Martin, Carole; Sapin, Hélène; Guerci, Bruno

    2013-01-01

    CHOICE (CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy) assessed patterns of exenatide bid and initial insulin therapy usage in clinical practice in six European countries and evaluated outcomes during the study. CHOICE was a 24-month, prospective, noninterventional observational study. Clinical and resource use data were collected at initiation of first injectable therapy (exenatide bid or insulin) and at regular intervals for 24 months. Costs were evaluated from the national health care system perspective at 2009 prices. A total of 2515 patients were recruited. At the 24-month analysis, significant treatment change had occurred during the study in 42.2% of 1114 eligible patients in the exenatide bid cohort and 36.0% of 1274 eligible patients in the insulin cohort. Improvements in glycemic control were observed over the course of the study in both cohorts (P bid cohort (P bid cohort and €3265.5 in the insulin cohort (€1791.9 versus €2465.5 due to costs other than those of injectable therapy). When baseline direct cost and patients' and disease characteristics were controlled for, mean direct costs differed by country (P bid, compared with insulin, therapy was compensated for by lower mean costs of other health service utilization. Costs associated with exenatide bid or insulin initiation varied across countries, highlighting the need to avoid generalization of resource use and cost implications of a particular therapy when estimated in specific country settings.

  17. [Clinical research XXI. From the clinical judgment to survival analysis].

    Science.gov (United States)

    Rivas-Ruiz, Rodolfo; Pérez-Rodríguez, Marcela; Palacios, Lino; Talavera, Juan O

    2014-01-01

    Decision making in health care implies knowledge of the clinical course of the disease. Knowing the course allows us to estimate the likelihood of occurrence of a phenomenon at a given time or its duration. Within the statistical models that allow us to have a summary measure to estimate the time of occurrence of a phenomenon in a given population are the linear regression (the outcome variable is continuous and normally distributed -time to the occurrence of the event-), logistic regression (outcome variable is dichotomous, and it is evaluated at one single interval), and survival curves (outcome event is dichotomous, and it can be evaluated at multiple intervals). The first reference we have of this type of analysis is the work of the astronomer Edmond Halley, an English physicist and mathematician, famous for the calculation of the appearance of the comet orbit, recognized as the first periodic comet (1P/Halley's Comet). Halley also contributed in the area of health to estimate the mortality rate for a Polish population. The survival curve allows us to estimate the probability of an event occurring at different intervals. Also, it leds us to estimate the median survival time of any phenomenon of interest (although the used term is survival, the outcome does not need to be death, it may be the occurrence of any other event).

  18. Merging genomic and phenomic data for research and clinical impact.

    Science.gov (United States)

    Shublaq, Nour W; Coveney, Peter V

    2012-01-01

    Driven primarily by advances in genomics, pharmacogenomics and systems biology technologies, large amounts of genomic and phenomic data are today being collected on individuals worldwide. Integrative analysis, mining, and computer modeling of these data, facilitated by information technology, have led to the development of predictive, preventive, and personalized medicine. This transformative approach holds the potential inter alia to enable future general practitioners and physicians to prescribe the right drug to the right patient at the right dosage. For such patient-specific medicine to be adopted as standard clinical practice, publicly accumulated knowledge of genes, proteins, molecular functional annotations, and interactions need to be unified and with electronic health records including phenotypic information, most of which still reside as paper-based records in hospitals. We review the state-of-the-art in terms of electronic data capture and medical data standards. Some of these activities are drawn from research projects currently being performed within the European Virtual Physiological Human (VPH) initiative; all are being monitored by the VPH INBIOMEDvision Consortium. Various ethical, legal and societal issues linked with privacy will increasingly arise in the post-genomic era. This will require a closer interaction between the bioinformatics/systems biology and medical informatics/healthcare communities. Planning for how individuals will own their personal health records is urgently needed, as the cost of sequencing a whole human genome will soon be less than U.S. $100. We discuss some of the issues that will need to be addressed by society as a result of this revolution in healthcare.

  19. Violence in Clinical Psychiatry. Proceedings of the 6th European congress

    NARCIS (Netherlands)

    Needham, I.; Callaghan, P.; Palmstierna, T.; Nijman, H.L.I.; Oud, N.E.

    2009-01-01

    This book of conference proceedings offers an overview of the work of many clinicians, researchers, and others on topics pertinent to the field of clinical violence such as legal and ethical perspectives on violence, the impact of violence on patients and staff, coercive measures, the

  20. Ethics of international clinical research collaboration - the experience of AlloStem.

    Science.gov (United States)

    Chaplin, C

    2006-02-01

    This paper examines the ethics of international clinical collaboration in stem cell research by focusing on the AlloStem project. AlloStem is an international research programme, financed by the European Union under the Sixth Framework Programme, with the aim of advancing the use of stem cells in treating leukaemia and other haematological diseases. Several areas of ethical importance are explored. Research justification and the need to consider both deontological and teleological aspects are examined. Ethical sensitivity in research and the requirement to respond to areas of ethical concern identified by the European Commission, such as the involvement of human beings, the use of human tissue, and the use of animals are also explored. Ethical issues around project structure and management, such as ethical standardization in international research, and achieving set targets are discussed. The ethical importance of dissemination of findings and teaching in clinical research is also considered. Finally, the distribution of benefits is addressed and the importance of distributive justice is emphasized.

  1. Transforming Research Management Systems at Mayo Clinic

    Science.gov (United States)

    Smith, Steven C.; Gronseth, Darren L.

    2011-01-01

    In order for research programs at academic medical centers and universities to survive and thrive in the increasingly challenging economic, political and regulatory environment, successful transformation is extremely important. Transformation and quality management techniques are increasingly well established in medical practice organizations. In…

  2. Guidelines for enhancing clinical supervision: research ...

    African Journals Online (AJOL)

    A qualitative, exploratory and descriptive research design was utilised where results from narrative sketches and literature control served as the basis for deducting and describing guidelines for enhancing reflection during the process of supervision. The conclusions drawn from the related findings are that the respondents ...

  3. Clinical Assessment Research with Older Adults.

    Science.gov (United States)

    La Rue, Asenath; Markee, Taryn

    1995-01-01

    Methodological issues in geropsychological assessment research are discussed and illustrated through recent investigations. Cross-sectional studies are needed to extend and diversify age norms, and short-term longitudinal studies should be planned to assess the predictive validity of test outcomes and diagnostic profiles of older adults. (SLD)

  4. Objectives | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The overall objective of CPTAC is to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, in order to understand the molecular basis of cancer that is not fully elucidated or not possible through genomics and to accelerate the translation of molecular findings into the clinic.  This is to be achieved through enhancing our understanding of cancer genome biology by adding a complementary functional layer of protein biology (a “proteogenome” approach) that refines/prioritizes driver genes, enhances understanding of pathogenesis

  5. 76 FR 19188 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2011-04-06

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit... DC/Silver Spring. Oncology June 9-10, 2011........ L'Enfant Plaza Hotel. ] Immunology June 9, 2011 L...

  6. 78 FR 66992 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2013-11-07

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Laboratory Research and Development and Clinical Science Research and Development Services Scientific Merit... Medicine........ November 25, 2013 *VA Central Office. Neurobiology-F November 26, 2013 *VA Central Office...

  7. European porphyria initiative (EPI): a platform to develop a common approach to the management of porphyrias and to promote research in the field.

    Science.gov (United States)

    Deybach, J-Ch; Badminton, M; Puy, H; Sandberg, S; Frank, J; Harper, P; Martasek, P; Minder, E; Parker, S; Thunell, S; Elder, G

    2006-01-01

    Porphyrias are uncommon inherited diseases of haem biosynthesis for which the diagnosis and treatment varies in individual countries. Despite the existence of guidelines recommended by porphyria experts concerning the diagnosis and management of the acute porphyrias, and of specialist centres in most European countries, many clinicians still do not apply these guidelines. The European Porphyia Initiative (EPI) network was formed in 2001 in order to compare experience among countries to attempt to develop a common approach to the management of the porphyrias, particularly concerning recommendation of safe and unsafe drugs, and to facilitate international collaborative clinical and biological research. The main achievements of EPI during this period have been: * Drafting and agreeing to consensus protocols for the diagnosis and management of acute hepatic porphyrias. * Creation of a multilingual website, particularly focusing on guidelines for common prescribing problems in acute porphyria and on providing information for patients that is now available in 10 languages: (www.porphyria-europe.org). EPI's current objectives are to develop the EPI platform, expand to new countries, extend to non-acute porphyrias and design European research and clinical trials in porphyria. The project will focus on: 1. Setting up a European laboratory external quality assurance scheme (EQAS) for biochemical and molecular investigations and their interpretation 2. Establishing a consensus drug list in collaboration with the Nordic porphyria network 3. Improving patient counseling 4. Developing large multi-centre, multi-national research projects. Due to the rarity of the porphyrias, it would be very difficult for any one country to provide this data with a sufficient number of patients and within a reasonable timescale. The progress achieved will facilitate improvements in the treatment and development of new therapeutic strategies. It will set a pattern for establishing, and

  8. Ethics of Cancer Gene Transfer Clinical Research.

    Science.gov (United States)

    Kimmelman, Jonathan

    2015-01-01

    Translation of cancer gene transfer confronts many familiar-and some distinctive-ethical challenges. In what follows, I survey three major ethical dimensions of cancer gene transfer development. Subheading 1 centers on the ethics of planning, designing, and reporting animal studies. Subheading 2 describes basic elements of human subjects protection as pertaining to cancer gene transfer. In Subheading 3, I describe how cancer gene transfer researchers have obligations to downstream consumers of the evidence they produce.

  9. Challenges of audit of care on clinical quality indicators for hypertension and type 2 diabetes across four European countries.

    Science.gov (United States)

    Suija, Kadri; Kivisto, Katrin; Sarria-Santamera, Antonio; Kokko, Simo; Liseckiene, Ida; Bredehorst, Maren; Jaruseviciene, Lina; Papp, Renata; Oona, Marje; Kalda, Ruth

    2015-02-01

    The purpose of the study was to measure clinical quality by doing an audit of clinical records and to compare the performance based on clinical quality indicators (CQI) for hypertension and type 2 diabetes across seven European countries: Estonia, Finland, Germany, Hungary, Italy, Lithuania and Spain. Two common chronic conditions in primary care (PC), hypertension and type 2 diabetes, were selected for audit. The assessment of CQI started with a literature review of different databases: Organization for Economic Co-operation and Development, World Health Organization, European Commission European Community Health Indicators, US National Library of Medicine. Data were collected from clinical records. Although it was agreed to obtain the clinical indicators in a similar way from each country, the specific data collection process in every country varied greatly, due to different traditions in collecting and keeping the patients' data, as well as differences in regulation regarding access to clinical information. Also, there was a huge variability across countries in the level of compliance with the indicators. Measurement of clinical performance in PC by audit is methodologically challenging: different databases provide different information, indicators of quality of care have insufficient scientific proof and there are country-specific regulations. There are large differences not only in quality of health care across Europe but also in how it is measured. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. Bringing a community-based vision to the heart of Europe's research the European Union's new research commissioner hopes that his plans to promote science will win over critics in the EU

    CERN Multimedia

    Dickson, D

    1999-01-01

    Busquin's top priority is to create an European scientific 'espace' to bring added value to European research efforts. He is also keen to give the commission's research programmes a more human face (1 page).

  11. Legitimating Clinical Research in the Study of Organizational Culture.

    Science.gov (United States)

    Schein, Edgar H.

    1993-01-01

    Argues that traditional research model used in industrial-organizational psychology is not useful in understanding deeper dynamics of organizations, especially those phenomena labeled as "cultural." Contends that use of data obtained during clinical and consulting work should be legitimated as valid research data. Spells out clinical model and…

  12. RESEARCH ON PROBLEMS WITH PROJECTS AND PARTNERSHIPS THAT PUBLIC INSTITUTIONS IN THE CENTRE REGION FACED IN ACCESSING EUROPEAN FUNDS

    Directory of Open Access Journals (Sweden)

    DUMITRASCU DANUT

    2012-12-01

    Full Text Available European project management is the main filed of the article. Assuming a connection between the degree of absorption of European funds and the degree of maturity of the Romanian society in terms of project management, the article seeks to identify the negative factors on accessing and carrying out European projects. The identified problem is a low degree of absorption of European funds in Romania, and the main objective of the research is to identify the problems faced by the public institutions in the Centre Region in accessing European funds and also the causes that led to the low absorption of European funds. This article’s research is based on a preliminary analysis performed by the authors on the rate of accessing of European funds published in the article called “The current state of European funds absorption through funding programmes – measure of the Romanian performances in the project management practice”. The conclusion of this article was a low rate of absorption of European funds in Romania, a fact that reveals a poor practice of the theory on project management. This article identifies part of the causes of this situation by identifying a part of the problems that stood in the way of beneficiaries of European funds The qualitative and quantitative research methods are used in combination in the research. The investigation has however a highly quantitative character, the purpose of the qualitative research being to provide the prerequisites for achieving the quantitative research. The interview-based qualitative research enabled the researcher to get acquainted with the subjects’ problems related to the theme of investigation, the causes that have generated these problems. This preliminary investigation to the questionnaire-based research aims to provide information that would help the researcher prepare the questionnaire, so that the questions allow getting the most comprehensive information to

  13. Physician participation in clinical research and trials: issues and approaches.

    Science.gov (United States)

    Rahman, Sayeeda; Majumder, Md Anwarul Azim; Shaban, Sami F; Rahman, Nuzhat; Ahmed, Moslehuddin; Abdulrahman, Khalid Bin; D'Souza, Urban Ja

    2011-01-01

    The rapid development of new drugs, therapies, and devices has created a dramatic increase in the number of clinical research studies that highlights the need for greater participation in research by physicians as well as patients. Furthermore, the potential of clinical research is unlikely to be reached without greater participation of physicians in research. Physicians face a variety of barriers with regard to participation in clinical research. These barriers are system-or organization-related as well as research-and physician-related. To encourage physician participation, appropriate organizational and operational infrastructures are needed in health care institutes to support research planning and management. All physicians should receive education and training in the fundamentals of research design and methodology, which need to be incorporated into undergraduate medical education and postgraduate training curricula and then reinforced through continuing medical education. Medical schools need to analyze current practices of teaching-learning and research, and reflect upon possible changes needed to develop a 'student-focused teaching-learning and research culture'. This article examines the barriers to and benefits of physician participation in clinical research as well as interventions needed to increase their participation, including the specific role of undergraduate medical education. The main challenge is the unwillingness of many physicians and patients to participate in clinical trials. Barriers to participation include lack of time, lack of resources, trial-specific issues, communication difficulties, conflicts between the role of clinician and scientist, inadequate research experience and training for physicians, lack of rewards and recognition for physicians, and sometimes a scientifically uninteresting research question, among others. Strategies to encourage physician participation in clinical research include financial and nonfinancial incentives

  14. Qualitative analysis of clinical research coordinators' role in phase I cancer clinical trials

    Directory of Open Access Journals (Sweden)

    Noriko Fujiwara

    2017-12-01

    Conclusions: Clinical research coordinators were insightful about the needs of patients and took a meticulous approach to the phase I cancer clinical trial process, allowing time to connect with patients and to coordinate the inter-professional research team. Additionally, education in advanced oncology care was valuable for comforting participants in cancer clinical trials.

  15. The Nephrology Clinical Research Nurse Role: Potential Role Conflicts.

    Science.gov (United States)

    Micklos, Lisa

    2016-01-01

    Clinical research nursing is becoming more visible to nephrology professionals. As more nephrology practices and units are participating in clinical trials, clinical research nursing is gaining interest as a career niche among nephrology nurses. This unique specialty requires that nephrology clinical nurse nurses (CRNs) reconcile the roles of nurse as caregiver and nurse as researcher, which may result in a role conflict. Nephrology nurses should be aware that they may experience this role conflict when transitioning from patient care to a position as a clinical research nurse. These nurses can rely on the American Nurses Association's Code of Ethics for Nurses and the Oncology Nursing Society's Oncology Clinical Trials Nurse Competencies to help reconcile the potential role conflict.

  16. Implementation of manufacturing data management application in the scientific research project. Case: CERN, the European Organization for Nuclear Research

    CERN Document Server

    Saifoulina, Margarita

    2010-01-01

    This Bachelor’s thesis examined the implementation process of an MTF (Manufacturing and Test Folder) application in the CLIC (Compact Linear Collider) Radio Frequency Structure Development project for manufacturing data management purposes. The primary goal of the study was to investigate how MTF implementation and its integration with CERN EDMS (Engineering and Equipment Data Management System) system could facilitate product life cycle through the supply chain, and could affect on manufacturing operations performance in internaland external levels. The aim of the study was also to find out implementation differences within CERN (European Organization for Nuclear Research) projects. The study is divided into two parts: a qualitative theory section and an empirical section. In the theory section differences of features between PDM (Product Data Management), EDM (Engineering Data Management) and PLM (Product Life Cycle Management) systems were studied. The thesis examined the benefits and managerial challeng...

  17. European recommendations for the clinical use of HIV drug resistance testing: 2011 update.

    Science.gov (United States)

    Vandamme, Anne-Mieke; Camacho, Ricardo J; Ceccherini-Silberstein, Francesca; de Luca, Andreu; Palmisano, Lucia; Paraskevis, Dimitrios; Paredes, Roger; Poljak, Mario; Schmit, Jean-Claude; Soriano, Vincent; Walter, Hauke; Sönnerborg, Anders

    2011-01-01

    The European HIV Drug Resistance Guidelines Panel, established to make recommendations to clinicians and virologists, felt that sufficient new information has become available to warrant an update of its recommendations, explained in both pocket guidelines and this full paper. The Panel makes the following recommendations concerning the indications for resistance testing: for HIV-1 (i) test earliest sample for protease and reverse transcriptase drug resistance in drug-naive patients with acute or chronic infection; (ii) test protease and reverse transcriptase drug resistance at virologic failure, and other drug targets (integrase and envelope) if such drugs were part of the failing regimen; (iii) consider testing for CCR5 tropism at virologic failure or when a change of therapy has to be made in absence of detectable viral load, and in the latter case test DNA or last detectable plasma RNA; (iv) consider testing earliest detectable plasma RNA when a successful nonnucleoside reverse transcriptase inhibitor-containing therapy was inappropriately interrupted; (v) genotype source patient when postexposure prophylaxis is considered; for HIV-2, (vi) consider resistance testing where treatment change is needed after treatment failure. The Panel recommends genotyping in most situations, using updated and clinically evaluated interpretation systems. It is mandatory that laboratories performing HIV resistance tests take part regularly in external quality assurance programs, and that they consider storing samples in situations where resistance testing cannot be performed as recommended. Similarly, it is necessary that HIV clinicians and virologists take part in continuous education and discuss problematic clinical cases. Indeed, resistance test results should be used in the context of all other clinically relevant information for predicting therapy response.

  18. Investigators' perspectives on translating human microbiome research into clinical practice.

    Science.gov (United States)

    Slashinski, M J; Whitney, S N; Achenbaum, L S; Keitel, W A; McCurdy, S A; McGuire, A L

    2013-01-01

    Human microbiome research has the potential to transform the practice of medicine, fundamentally shifting the ways in which we think not only about human health, illness and disease, but also about clinical practice and public health interventions. Drawing from a larger qualitative study on ethical, legal and social dimensions of human microbiome research, in this article, we document perspectives related to the translation of human microbiome research into clinical practice, focusing particularly on implications for health, illness and disease. We conducted 60 in-depth, semi-structured interviews (2009-2010) with 63 researchers and National Institutes of Health project leaders ('investigators') involved with human microbiome research. The interviews explored a range of ethical, legal and social implications of human microbiome research, including investigators' perspectives on potential strategies for translating findings to clinical practice. Using thematic content analysis, we identified and analyzed emergent themes and patterns. We identified 3 themes: (1) investigators' general perspectives on the clinical utility of human microbiome research, (2) investigators' perspectives on antibiotic use, overuse and misuse, and (3) investigators' perspectives concerning future challenges of translating data to clinical practice. The issues discussed by investigators concerning the clinical significance of human microbiome research, including embracing a new paradigm of health and disease, the importance of microbial communities, and clinical utility, will be of critical importance as this research moves forward. Copyright © 2013 S. Karger AG, Basel.

  19. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study

    NARCIS (Netherlands)

    Luca, G. De; Haba-Rubio, J.; Dauvilliers, Y.; Lammers, G.J.; Overeem, S.; Donjacour, C.E.; Mayer, G.; Javidi, S.; Iranzo, A.; Santamaria, J.; Peraita-Adrados, R.; Hor, H.; Kutalik, Z.; Plazzi, G.; Poli, F.; Pizza, F.; Arnulf, I.; Lecendreux, M.; Bassetti, C.; Mathis, J.; Heinzer, R.; Jennum, P.; Knudsen, S.; Geisler, P.; Wierzbicka, A.; Feketeova, E.; Pfister, C.; Khatami, R.; Baumann, C.; Tafti, M.

    2013-01-01

    The aim of this study was to describe the clinical and PSG characteristics of narcolepsy with cataplexy and their genetic predisposition by using the retrospective patient database of the European Narcolepsy Network (EU-NN). We have analysed retrospective data of 1099 patients with narcolepsy

  20. The effect of certification and accreditation on quality management in 4 clinical services in 73 European hospitals.

    NARCIS (Netherlands)

    Shaw, C.D.; Groene, O.; Botje, D.; Suñol, R.; Kutryba, B.; Klazinga, N.; Bruneau, C.; Hammer, A.; Wang, A.; Arah, O.A.; Wagner, C.

    2014-01-01

    Objective: To investigate the relationship between ISO 9001 certification, healthcare accreditation and quality management in European hospitals. Design: A mixed method multi-level cross-sectional design in seven countries. External teams assessed clinical services on the use of quality management

  1. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons

    NARCIS (Netherlands)

    Ryom, L.; Boesecke, C.; Gisler, V.; Manzardo, C.; Rockstroh, J. K.; Puoti, M.; Furrer, H.; Miro, J. M.; Gatell, J. M.; Pozniak, A.; Behrens, G.; Battegay, M.; Lundgren, J. D.; Lundgren, Jens D.; Ryom, Lene; Gatell, José M.; Pozniak, Anton; Manzardo, Christian; Monforte, Antonella d'Arminio; Arribas, José; Battegay, Manuel; Clumeck, Nathan; Dedes, Nikos; Geretti, Anna Maria; Horban, Andrzej; Katlama, Christina; McCormack, Sheena; Molina, Jean-Michel; Mussini, Cristina; Raffi, François; Reiss, Peter; Stellbrink, Hans-Jürgen; Behrens, Georg; Bower, Mark; Cinque, Paola; Collins, Simon; Compston, Juliet; Deray, Gilbert; de Wit, Stéphane; Fux, Christoph A.; Guraldi, Giovanni; Mallon, Patrick; Martinez, Esteban; Marzolini, Catia; Papapoulos, Socrates; Du Pasquier, Renaud; Poulter, Neil; Williams, Ian; Winston, Alan; Rockstroh, Jürgen K.; Puoti, Massimo; Boesecke, Christoph; Bhagani, Sanjay; Bruno, Raffaele; Konov, Svilen; Lacombe, Karine; Mauss, Stefan; Mendao, Luis; Peters, Lars; Rauch, Andri; Tural, Cristina; Furrer, Hansjakob; Miro, Jose M.; Gisler, Valentin; Fätkenkeuer, Gerd; Kirk, Ole; Mocroft, Amanda; Morlat, Philippe; Volny-Anne, Alain; Mulcahy, Fiona; Katlama, Christine; Oprea, Cristiana; Youle, Mike

    2016-01-01

    BackgroundThe European AIDS Clinical Society (EACS) guidelines are intended for all clinicians involved in the care of HIV-positive persons, and are available in print, online, and as a free App for download for iPhone and Android. Guideline highlightsThe 2015 version of the EACS guidelines contains

  2. Quality of Care and Job Satisfaction in the European Home Care Setting: Research Protocol

    Directory of Open Access Journals (Sweden)

    Liza Van Eenoo

    2016-08-01

    Full Text Available Introduction: Since the European population is ageing, a growing number of elderly will need home care. Consequently, high quality home care for the elderly remains an important challenge. Job satisfaction among care professionals is regarded as an important aspect of the quality of home care. Aim: This paper describes a research protocol to identify elements that have an impact on job satisfaction among care professionals and on quality of care for older people in the home care setting of six European countries. Methods: Data on elements at the macro-level (policy, meso-level (care organisations and micro-level (clients are of importance in determining job satisfaction and quality of care. Macro-level indicators will be identified in a previously published literature review. At meso- and micro-level, data will be collected by means of two questionnaires utilsed with both care organisations and care professionals, and by means of interRAI Home Care assessments of clients. The client assessments will be used to calculate quality of care indicators. Subsequently, data will be analysed by means of linear and stepwise multiple regression analyses, correlations and multilevel techniques. Conclusions and Discussion: These results can guide health care policy makers in their decision making process in order to increase the quality of home care in their organisation, in their country or in Europe.

  3. European research activities within the project: High Performance Light Water Reactor phase 2 (HPLWR phase 2)

    Energy Technology Data Exchange (ETDEWEB)

    Starflinger, J.; Schulenberg, T. [Forschungszentrum Karlsruhe GmbH, Institute for Nuclear and Energy Technologies, Karlsruhe (Germany); Marsault, P. [CEA Cadarache (DER/SESI), 13 - Saint Paul lez Durance (France). Dept. d' Etudes des Reacteurs; Bittermann, D. [AREVA NP, NEPR-G, Erlangen (Germany); Maraczy, C. [AEKI-KFKI, Budapest (Hungary); Laurien, E. [Stuttgart Univ. IKE (Germany); Lycklama, J.A. [NRG Petten, NL (Netherlands); Anglart, H. [KTH Energy Technology, Stockholm (Sweden); Aksan, N. [Paul Scherrer Institut CH, Villigen PSI (Switzerland); Ruzickova, M. [UJV Rez plc, Husinec-Rez c.p. (Czech Republic); Heikinheimo, L. [VTT, FIN (Finland)

    2007-07-01

    The High Performance Light Water Reactor (HPLWR) is a Light Water Reactor (LWR) operating at supercritical pressure (25 MPa). It belongs to the six reactors currently being investigated under the framework of the Generation IV International Forum. The most visible advantage of the HPLWR shall be the low construction costs in the order of 1000 Euro/kWe, because of size reduction of components and buildings compared to current Light Water Reactors, and the low electricity production costs which are targeted at 3-4 cents/kWh. In Europe, investigations on the HPLWR have been integrated into a joint research project, called High Performance Light Water Reactor Phase 2 (HPLWR Phase 2), which is co-funded by the European Commission. Within 42 months, ten partners from eight European countries working on critical scientific issues shall show the feasibility of the HPLWR concept. This paper reports on 5 points relevant for HPLWR: 1) design and integration, 2) core design, 3) safety, 4) materials, and 5) heat transfer. The final goal is to assess the future potential of this reactor in the electricity market.

  4. Quality of Care and Job Satisfaction in the European Home Care Setting: Research Protocol.

    Science.gov (United States)

    Van Eenoo, Liza; van der Roest, Henriëtte; van Hout, Hein; Declercq, Anja

    2016-08-31

    Since the European population is ageing, a growing number of elderly will need home care. Consequently, high quality home care for the elderly remains an important challenge. Job satisfaction among care professionals is regarded as an important aspect of the quality of home care. This paper describes a research protocol to identify elements that have an impact on job satisfaction among care professionals and on quality of care for older people in the home care setting of six European countries. Data on elements at the macro-level (policy), meso-level (care organisations) and micro-level (clients) are of importance in determining job satisfaction and quality of care. Macro-level indicators will be identified in a previously published literature review. At meso- and micro-level, data will be collected by means of two questionnaires utilsed with both care organisations and care professionals, and by means of interRAI Home Care assessments of clients. The client assessments will be used to calculate quality of care indicators. Subsequently, data will be analysed by means of linear and stepwise multiple regression analyses, correlations and multilevel techniques. These results can guide health care policy makers in their decision making process in order to increase the quality of home care in their organisation, in their country or in Europe.

  5. Responsible decision-making for plant research and breeding innovations in the European Union.

    Science.gov (United States)

    Eriksson, Dennis; Chatzopoulou, Sevasti

    2017-10-09

    Plant research and breeding has made substantial technical progress over the past few decades, indicating a potential for tremendous societal impact. Due to this potential, the development of policies and legislation on plant breeding and the technical progress should preferably involve all relevant stakeholders. However, we argue here that there is a substantial imbalance in the European Union (EU) regarding the influence of the various stakeholder groups on policy makers. We use evidence from three examples in order to show that the role of science is overlooked: 1) important delays in the decision process concerning the authorization of genetically modified (GM) maize events, 2) the significance attributed to non-scientific reasons in new legislation concerning the prohibition of GM events in EU member states, and 3) failure of the European Commission to deliver legal guidance to new plant breeding techniques despite sufficient scientific evidence and advisory reports. We attribute this imbalance to misinformation and misinterpretation of public perceptions and a disproportionate attention to single outlier reports, and we present ideas on how to establish a better stakeholder balance within this field.

  6. BEER - The Beamline for European Materials Engineering Research at the ESS

    Science.gov (United States)

    Fenske, J.; Rouijaa, M.; Šaroun, J.; Kampmann, R.; Staron, P.; Nowak, G.; Pilch, J.; Beran, P.; Šittner, P.; Strunz, P.; Brokmeier, H.-G.; Ryukhtin, V.; Kadeřávek, L.; Strobl, M.; Müller, M.; Lukáš, P.; Schreyer, A.

    2016-09-01

    The Beamline for European Materials Engineering Research (BEER) will be built at the European Spallation Source (ESS). The diffractometer utilizes the high brilliance of the long-pulse neutron source and offers high instrument flexibility. It includes a novel chopper technique that extracts several short pulses out of the long pulse, leading to substantial intensity gain of up to an order of magnitude compared to pulse shaping methods for materials with high crystal symmetry. This intensity gain is achieved without compromising resolution. Materials of lower crystal symmetry or multi-phase materials will be investigated by additional pulse shaping methods. The different chopper set-ups and advanced beam extracting techniques offer an extremely broad intensity/resolution range. Furthermore, BEER offers an option of simultaneous SANS or imaging measurements without compromising diffraction investigations. This flexibility opens up new possibilities for in-situ experiments studying materials processing and performance under operation conditions. To fulfil this task, advanced sample environments, dedicated to thermo-mechanical processing, are foreseen.

  7. The European Safeguards Research and Development Association Addresses Safeguards and Nonproliferation

    Energy Technology Data Exchange (ETDEWEB)

    Janssens-Maenhout, Greet; Kusumi, R.; Daures, Pascal A.; Janssens, Willem; Dickman, Deborah A.

    2010-06-16

    The renaissance of efforts to expand the use of nuclear energy requires the parallel development of a renewed and more sophisticated work force. Growth in the nuclear sector with high standard of safety, safeguards and security requires skilled staff for design, operations, inspections etc. High-quality nuclear technology educational programs are diminished from past years, and the ability of universities to attract students and to meet future staffing requirements of the nuclear industry is becoming seriously compromised. Thus, education and training in nuclear engineering and sciences is one of the cornerstones for the nuclear sector. Teaching in the nuclear field still seems strongly influenced by national history but it is time to strengthen resources and collaborate. Moreover with the current nuclear security threats it becomes critical that nuclear technology experts master the basic principles not only of safety, but also of nuclear safeguards, nonproliferation and nuclear security. In Europe the European Nuclear Education Network (ENEN) Association has established the certificate 'European Master of Science in Nuclear Engineering (EMSNE)' as the classic nuclear engineering program covering reactor operation and nuclear safety. However, it does not include courses on nonproliferation, safeguards, or dual-use technologies. The lack of education in nuclear safeguards was tackled by the European Safeguards Research and Development Association (ESARDA), through development and implementation of safeguards course modules. Since 2005 the ESARDA Working Group, called the Training and Knowledge Management Working Group, (TKMWG) has worked with the Joint Research Centre (JRC) in Ispra, Italy to organize a Nuclear Safeguards and Nonproliferation course. This five-day course is held each spring at the JRC, and continues to show increasing interest as evidenced by the positive responses of international lecturers and students. The standard set of lectures

  8. [Clinical research in the "acute and chronic leukemias"competence network ].

    Science.gov (United States)

    Hehlmann, R; Berger, U; Aul, C; Büchner, T; Döhner, H; Ehninger, G; Ganser, A; Hoelzer, D; Gökbuget, N; Uberla, K

    2004-04-01

    Goal of the network is the construction of an exemplary cooperative leukemia network for the improvement of medical care and of health related research in acute and chronic leukemias. This is achieved by improved mechanisms of cooperation among all major groups in Germany that deal with the leukemias in research and in patient care. In practice, cooperation between clinical groups and scientists in research institutes is mediated by various instruments that improve communication, flow of information and interdisciplinary cooperation and also increase information transfer from top research institutions to clinical translation. The network comprises more than 1400 participants in about 400 university centers, large community hospitals and specialty practices with functional communication structures, interdisciplinary cooperation and nation-wide logistics. The improved cooperation and the accelerated information transfer from the bench to the "bedside" results in an added value that ultimately results in improved survival results of patients and in superior competitiveness of involved research workers and clinicians. Sustainability is addressed by establishing a leukemia foundation to support long term financial coverage of the network and by negotiating a proposal for a European Network of Excellence against leukemia within the Sixth Framework Programme of the European Union.

  9. Personalized neuromusculoskeletal modeling to improve treatment of mobility impairments: a perspective from European research sites

    Directory of Open Access Journals (Sweden)

    Fregly Benjamin J

    2012-03-01

    Full Text Available Abstract Mobility impairments due to injury or disease have a significant impact on quality of life. Consequently, development of effective treatments to restore or replace lost function is an important societal challenge. In current clinical practice, a treatment plan is often selected from a standard menu of options rather than customized to the unique characteristics of the patient. Furthermore, the treatment selection process is normally based on subjective clinical experience rather than objective prediction of post-treatment function. The net result is treatment methods that are less effective than desired at restoring lost function. This paper discusses the possible use of personalized neuromusculoskeletal computer models to improve customization, objectivity, and ultimately effectiveness of treatments for mobility impairments. The discussion is based on information gathered from academic and industrial research sites throughout Europe, and both clinical and technical aspects of personalized neuromusculoskeletal modeling are explored. On the clinical front, we discuss the purpose and process of personalized neuromusculoskeletal modeling, the application of personalized models to clinical problems, and gaps in clinical application. On the technical front, we discuss current capabilities of personalized neuromusculoskeletal models along with technical gaps that limit future clinical application. We conclude by summarizing recommendations for future research efforts that would allow personalized neuromusculoskeletal models to make the greatest impact possible on treatment design for mobility impairments.

  10. Progress in clinical research of asteroid hyalosis

    Directory of Open Access Journals (Sweden)

    Xiao-Xue Liu

    2017-08-01

    Full Text Available Asteroid Hyalosis(AHis a common clinical disease, which has been considered a benign disorder as it rarely impairs visual acuity. It was often discovered when the patient was treated for other eye diseases. The mechanism was unclear. Its characteristic B-ultrasound property makes the B-ultrasound a very helpful diagnostic technique. In the case of the patients with other fundus diseases associated with AH, optical coherence tomography(OCTand fluorescein angiography(FAmay be used to reduce the interference from asteroid bodies, therefore improve the fundus visibility. Recent studies have shown that AH can incorporate with many other eye diseases. For example, in patients with cataracts, asteroid hyalosis can cause surface calcification of silicone plate intraocular lenses, which in most cases may lead to the need for explantation of the calcified intraocular lenses. The efficacy of pars plana vitrectomy(PPV, the removal of some, or all, of the eye's vitreous humor for AH remains controversial. In this paper, we provide a review of the recent literature on AH disease: the etiology, diagnosis and treatment. We hope to thus improve the awareness and outcomes of AH disease.

  11. Data management by using R: big data clinical research series.

    Science.gov (United States)

    Zhang, Zhongheng

    2015-11-01

    Electronic medical record (EMR) system has been widely used in clinical practice. Instead of traditional record system by hand writing and recording, the EMR makes big data clinical research feasible. The most important feature of big data research is its real-world setting. Furthermore, big data research can provide all aspects of information related to healthcare. However, big data research requires some skills on data management, which however, is always lacking in the curriculum of medical education. This greatly hinders doctors from testing their clinical hypothesis by using EMR. To make ends meet, a series of articles introducing data management techniques are put forward to guide clinicians to big data clinical research. The present educational article firstly introduces some basic knowledge on R language, followed by some data management skills on creating new variables, recoding variables and renaming variables. These are very basic skills and may be used in every project of big data research.

  12. Using electronic health records for clinical research: the case of the EHR4CR project.

    Science.gov (United States)

    De Moor, Georges; Sundgren, Mats; Kalra, Dipak; Schmidt, Andreas; Dugas, Martin; Claerhout, Brecht; Karakoyun, Töresin; Ohmann, Christian; Lastic, Pierre-Yves; Ammour, Nadir; Kush, Rebecca; Dupont, Danielle; Cuggia, Marc; Daniel, Christel; Thienpont, Geert; Coorevits, Pascal

    2015-02-01

    To describe the IMI EHR4CR project which is designing and developing, and aims to demonstrate, a scalable, widely acceptable and efficient approach to interoperability between EHR systems and clinical research systems. The IMI EHR4CR project is combining and extending several previously isolated state-of-the-art technical components through a new approach to develop a platform for reusing EHR data to support medical research. This will be achieved through multiple but unified initiatives across different major disease areas (e.g. cardiovascular, cancer) and clinical research use cases (protocol feasibility, patient identification and recruitment, clinical trial execution and serious adverse event reporting), with various local and national stakeholders across several countries and therefore under various legal frameworks. An initial instance of the platform has been built, providing communication, security and terminology services to the eleven participating hospitals and ten pharmaceutical companies located in seven European countries. Proof-of-concept demonstrators have been built and evaluated for the protocol feasibility and patient recruitment scenarios. The specifications of the clinical trial execution and the adverse event reporting scenarios have been documented and reviewed. Through a combination of a consortium that brings collectively many years of experience from previous relevant EU projects and of the global conduct of clinical trials, of an approach to ethics that engages many important stakeholders across Europe to ensure acceptability, of a robust iterative design methodology for the platform services that is anchored on requirements of an underlying Service Oriented Architecture that has been designed to be scalable and adaptable, EHR4CR could be well placed to deliver a sound, useful and well accepted pan-European solution for the reuse of hospital EHR data to support clinical research studies. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. An Integrative Review of Engaging Clinical Nurses in Nursing Research.

    Science.gov (United States)

    Scala, Elizabeth; Price, Carrie; Day, Jennifer

    2016-07-01

    To review the literature for best practices for engaging clinical nurses in nursing research. Review of the research and nonresearch papers published between 2005 and 2015 that answered the evidence-based practice (EBP) question: what are the best practices for engaging clinical nursing staff in nursing research? PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Joanna Briggs Institute, and Cochrane were searched using a combination of controlled vocabulary and key words. Nineteen papers that answered the EBP question were selected for review. It can be difficult to involve clinical nurses in research. There are multiple factors to consider when nursing leadership looks to engage clinical nurses in nursing research. Nurse leaders can take many approaches to engage clinical nurses in research. Each organization must perform its own assessment to identify areas of opportunity. Nursing leadership can take these areas of opportunity to structure a multifaceted approach to support clinical staff in the conduct and dissemination of nursing research. The evidence from this review offers EBP recommendations as well as reports on the gaps in the literature related to best practices for engaging clinical nurses in nursing research. © 2016 Sigma Theta Tau International.

  14. On using people merely as a means in clinical research.

    Science.gov (United States)

    van der Graaf, Rieke; van Delden, Johannes J M

    2012-02-01

    It is often argued that clinical research should not violate the Kantian principle that people must not be used merely as a means for the purposes of others. At first sight, the practice of clinical research itself, however, seems to violate precisely this principle: clinical research is often beneficial to future people rather than to participants; even if participants benefit, all things considered, they are exposed to discomforts which are absent both in regular care for their diseases and in other areas of daily life. Therefore, in this paper we will consider whether people are used merely as a means by being enrolled in clinical research. On the basis of recent studies of Kantian scholars we will argue that clinical research is compatible with the Kantian principle if the conditions of possible consent and end-sharing have been met. Participants are not used merely as a means if they have sufficient reasons to consent to being enrolled in clinical research and can share the ends of the researchers who use them. Moreover, we will claim that even if people are used merely as a means by participating in clinical research, it may not always be morally wrong to use them in this way. © 2010 Blackwell Publishing Ltd.

  15. [Organization of clinical research: in general and visceral surgery].

    Science.gov (United States)

    Schneider, M; Werner, J; Weitz, J; Büchler, M W

    2010-04-01

    The structural organization of research facilities within a surgical university center should aim at strengthening the department's research output and likewise provide opportunities for the scientific education of academic surgeons. We suggest a model in which several independent research groups within a surgical department engage in research projects covering various aspects of surgically relevant basic, translational or clinical research. In order to enhance the translational aspects of surgical research, a permanent link needs to be established between the department's scientific research projects and its chief interests in clinical patient care. Importantly, a focus needs to be placed on obtaining evidence-based data to judge the efficacy of novel diagnostic and treatment concepts. Integration of modern technologies from the fields of physics, computer science and molecular medicine into surgical research necessitates cooperation with external research facilities, which can be strengthened by coordinated support programs offered by research funding institutions.

  16. Towards supporting scholarship in research by clinical pharmacy faculty.

    Science.gov (United States)

    Pickard, A Simon

    2006-10-01

    The objective of this study was to assess the need for research support, faculty development, and topics of interest to clinical track pharmacy faculty that would facilitate scholarship in research. A cross-sectional survey of pharmacy practice-based faculty at University of Illinois at Chicago (UIC) completed via the web in November 2005. Of 39 clinical track faculty respondents (48% response rate), 100% indicated they were interested in being co-investigator or 77% lead investigator on a research grant proposal. The majority of respondents expressed "a lot" or "extreme" interest in receiving methodological guidance and administrative support in order to pursue research interests. The greatest interest in research support services related to sample size calculations, selection of appropriate statistical tests, grant writing, and writing for journals. Barriers to research cited by faculty included lack of confidence in ability, the need for balancing responsibilities, and reward for efforts. Suggestions included the creation of specific research interest groups, research seminars, formal mentoring and statistical support services. Clinical-track faculty are interested in research-related scholarship but typically lack the confidence or skills to lead research. While this study was limited to UIC clinical faculty, UIC faculty are attracted from Colleges of Pharmacy across North America and it is notable that such barriers can be quickly identified using a brief web-based survey in order to inform a plan that provides resources and support for research by clinical pharmacy faculty.

  17. Towards supporting scholarship in research by clinical pharmacy faculty

    Directory of Open Access Journals (Sweden)

    Pickard AS

    2006-12-01

    Full Text Available Objective: The objective of this study was to assess the need for research support, faculty development, and topics of interest to clinical track pharmacy faculty that would facilitate scholarship in research.Methods: A cross-sectional survey of pharmacy practice-based faculty at University of Illinois at Chicago (UIC completed via the web in November 2005.Results: Of 39 clinical track faculty respondents (48% response rate, 100% indicated they were interested in being co-investigator or 77% lead investigator on a research grant proposal. The majority of respondents expressed “a lot” or “extreme” interest in receiving methodological guidance and administrative support in order to pursue research interests. The greatest interest in research support services related to sample size calculations, selection of appropriate statistical tests, grant writing, and writing for journals. Barriers to research cited by faculty included lack of confidence in ability, the need for balancing responsibilities, and reward for efforts. Suggestions included the creation of specific research interest groups, research seminars, formal mentoring and statistical support services.Conclusions: Clinical-track faculty are interested in research-related scholarship but typically lack the confidence or skills to lead research. While this study was limited to UIC clinical faculty, UIC faculty are attracted from Colleges of Pharmacy across North America and it is notable that such barriers can be quickly identified using a brief web-based survey in order to inform a plan that provides resources and support for research by clinical pharmacy faculty.

  18. The framework of family therapy in clinical practice and research in Serbia.

    Science.gov (United States)

    Pantovic, Maja; Dunjic-Kostic, Bojana; Ivkovic, Maja; Damjanovic, Aleksandar; Jovanovic, Aleksandar A

    2012-04-01

    In the last two decades, Serbia has had to deal with multiple social and economic problems reflecting on society's demographics and seemed to weaken its core cell - the family. The paper describes the framework of family therapy in clinical practice and research, within the recent transition of the Serbian family. Family therapy treatment in Serbia uses the systemic family therapy (SFT) approach, applied according to the standards of the European Association for Psychotherapy. A large number of professionals who practise in Serbia hold European qualifications, setting high standards in education, clinical practice, and research. Although SFT is also available in the private sector, the majority of patients are still treated in state institutions. Family therapy is often used for adults and adolescents with psychosis and addictions in psychiatric hospital settings. However, in counselling centres it is used for marital and relationship problems. Interestingly, family therapy has recently started to emerge as a more frequent tool in consultation-liaison, particularly psycho-oncology but also in correctional institutions. The clinical practice and research interests are interlinked with changes in social settings.

  19. EU FP7 project 'CAMbrella' to build European research network for complementary and alternative medicine

    DEFF Research Database (Denmark)

    Weidenhammer, Wolfgang; Lewith, George; Falkenberg, Torkel

    2011-01-01

    . A coordination project funded by the EU has been launched to improve the knowledge about CAM in Europe. OBJECTIVES AND METHODS: The project aims to evaluate the conditions surrounding CAM use and provision in Europe and to develop a roadmap for European CAM research. Specific objectives are to establish an EU...... and will run for 36 months starting from January 2010. The project will be delivered in 9 work packages coordinated by a Management Board and directed by a Scientific Steering Committee with support of an Advisory Board. OUTPUT: The outcomes generated will be disseminated through the project's website, peer......BACKGROUND: The status of complementary and alternative medicine (CAM) within the EU needs clarification. The definition and terminology of CAM is heterogeneous. The therapies, legal status, regulations and approaches used vary from country to country but there is widespread use by EU citizens...

  20. Influenza Vaccine Research funded by the European Commission FP7-Health-2013-Innovation-1 project.

    Science.gov (United States)

    Liu, Heng; Frijlink, Henderik W; Huckriede, Anke; van Doorn, Eva; Schmidt, Ed; Leroy, Odile; Rimmelzwaan, Guus; McCullough, Keneth; Whelan, Mike; Hak, Eelko

    2016-11-21

    Due to influenza viruses continuously displaying antigenic variation, current seasonal influenza vaccines must be updated annually to include the latest predicted strains. Despite all the efforts put into vaccine strain selection, vaccine production, testing, and administration, the protective efficacy of seasonal influenza vaccines is greatly reduced when predicted vaccine strains antigenically mismatch with the actual circulating strains. Moreover, preparing for a pandemic outbreak is a challenge, because it is unpredictable which strain will cause the next pandemic. The European Commission has funded five consortia on influenza vaccine development under the Seventh Framework Programme for Research and Technological Development (FP7) in 2013. The call of the EU aimed at developing broadly protective influenza vaccines. Here we review the scientific strategies used by the different consortia with respect to antigen selection, vaccine delivery system, and formulation. The issues related to the development of novel influenza vaccines are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Food-related lifestyles in Singapore: Testing a Western European research instrument in Southeast Asia

    DEFF Research Database (Denmark)

    Askegaard, Søren; Brunsø, Karen; Crippen, Kaye

    The food-realaed life style instrument developed by the MAPP research group has, up till now, been applied mainly in the context of European cultures. The purpose of the present study is to apply the food-related life style instrument in a new and different cultural setting, to compare results......, and to interpret similarities and differences found. For this purpose, data have been collected in Singaporean families using the food-related life style insrurment. A total of 89 questionnaires form the basis of the analysis. First, the cross-cultural validity of the instrument is tested, and secondly......, in the light of those results, we interpret the results in relationship to local food cultures....

  2. Integration of clinical research documentation in electronic health records.

    Science.gov (United States)

    Broach, Debra

    2015-04-01

    Clinical trials of investigational drugs and devices are often conducted within healthcare facilities concurrently with clinical care. With implementation of electronic health records, new communication methods are required to notify nonresearch clinicians of research participation. This article reviews clinical research source documentation, the electronic health record and the medical record, areas in which the research record and electronic health record overlap, and implications for the research nurse coordinator in documentation of the care of the patient/subject. Incorporation of clinical research documentation in the electronic health record will lead to a more complete patient/subject medical record in compliance with both research and medical records regulations. A literature search provided little information about the inclusion of clinical research documentation within the electronic health record. Although regulations and guidelines define both source documentation and the medical record, integration of research documentation in the electronic health record is not clearly defined. At minimum, the signed informed consent(s), investigational drug or device usage, and research team contact information should be documented within the electronic health record. Institutional policies should define a standardized process for this integration in the absence federal guidance. Nurses coordinating clinical trials are in an ideal position to define this integration.

  3. Patients' satisfaction with sexual and reproductive health services delivered in HIV clinics across European regions.

    Science.gov (United States)

    Platteau, Tom; Müller, Matthias C; Nideröst, Sibylle; Csepe, Peter; Dedes, Nikos; Apers, Ludwig; Schrooten, Ward; Nöstlinger, Christiana

    2013-09-01

    Throughout Europe, differences in satisfaction with HIV-care of people living with HIV (PLHIV) persist, despite a tendency towards harmonisation of policy and management. A European sample of 1,549 PLHIV responded to an anonymous questionnaire assessing demographic background, general health, mental health, sexual health, and HIV-service provision. We compared the results across 3 regions: Western, Southern and Central/Eastern Europe. PLHIV differed in several socio-demographic variables (gender, migrant status, sexual orientation, and financial situation) as well as specific psychosocial aspects (HIV-related discrimination, satisfaction with sexual and reproductive health (SRH) services in HIV-care settings, and complaints about service provision). Using multivariate analysis, a predictive model for satisfaction with SRH services in HIV clinics was developed, resulting into region of residence, and participants' satisfaction with their own health status as significant predictors. Better integration of SRH services in HIV-care should be encouraged. Service providers should be trained and encouraged to discuss SRH issues with their patients to create a supportive environment, free of discrimination. More time should be allocated to discuss SRH issues with individual patients.

  4. Crossing borders : review of concepts and approaches in research on greenspace, immigration and society in northwest European countries

    NARCIS (Netherlands)

    Kloek, M.E.; Buijs, A.E.; Boersema, J.J.; Schouten, M.G.C.

    2013-01-01

    Relations between greenspace, immigration and society are emerging issues in policy and science. However, up to now research has been fragmented and no overview of approaches exists. This review describes concepts and approaches in Northwest European research on immigrants’ recreational use and

  5. European Union and Greek Lifelong Learning Policy within an Intercultural Context: Preliminary Insights from Research in the Sociology of Law

    Science.gov (United States)

    Koutidou, Evangelia

    2014-01-01

    This paper presents preliminary findings of an extensive socio-legal research project, currently in progress, concerning the implementation of the European Union and the Greek institutional framework on lifelong learning (LLL) and exploring the social effectiveness of LLL policy. The main outcomes, based on testing two research hypotheses through…

  6. Scientometric Approaches to Better Visibility of European Educational Research Publications: A State-of-the-Art-Report

    Science.gov (United States)

    Botte, Alexander

    2007-01-01

    This article reports on methodological approaches to evaluate the relevance and quality of educational research publications. In the first section it focuses on the ISI Social Science Citation Index and shows that this standard instrument for bibliometric measurement is insufficient for the representation of European educational research. In the…

  7. A survey of patients' attitudes to clinical research.

    LENUS (Irish Health Repository)

    Desmond, A

    2011-04-01

    Every year hundreds of patients voluntarily participate in clinical trials across Ireland. However, little research has been done as to how patients find the experience. This survey was conducted in an attempt to ascertain clinical trial participants\\' views on their experience of participating in a clinical trial and to see and how clinical trial participation can be improved. One hundred and sixty-six clinical trial participants who had recently completed a global phase IV cardiovascular endpoint clinical trial were sent a 3-page questionnaire. Ninety-one (91%) respondents found the experience of participating in a clinical trial a good one with 85 (84.16%) respondents saying they would recommend participating in a clinical trial to a friend or relative and eighty-five (87.63%) respondents feeling they received better healthcare because they had participated in a clinical trial.

  8. A metadata schema for data objects in clinical research.

    Science.gov (United States)

    Canham, Steve; Ohmann, Christian

    2016-11-24

    A large number of stakeholders have accepted the need for greater transparency in clinical research and, in the context of various initiatives and systems, have developed a diverse and expanding number of repositories for storing the data and documents created by clinical studies (collectively known as data objects). To make the best use of such resources, we assert that it is also necessary for stakeholders to agree and deploy a simple, consistent metadata scheme. The relevant data objects and their likely storage are described, and the requirements for metadata to support data sharing in clinical research are identified. Issues concerning persistent identifiers, for both studies and data objects, are explored. A scheme is proposed that is based on the DataCite standard, with extensions to cover the needs of clinical researchers, specifically to provide (a) study identification data, including links to clinical trial registries; (b) data object characteristics and identifiers; and (c) data covering location, ownership and access to the data object. The components of the metadata scheme are described. The metadata schema is proposed as a natural extension of a widely agreed standard to fill a gap not tackled by other standards related to clinical research (e.g., Clinical Data Interchange Standards Consortium, Biomedical Research Integrated Domain Group). The proposal could be integrated with, but is not dependent on, other moves to better structure data in clinical research.

  9. Bridging the gap between clinical research and clinical practice: introduction to the special section.

    Science.gov (United States)

    Teachman, Bethany A; Drabick, Deborah A G; Hershenberg, Rachel; Vivian, Dina; Wolfe, Barry E; Goldfried, Marvin R

    2012-06-01

    This Special Section, developed by the American Psychology Association's Division 12 (Clinical) 2011 Committee on Science and Practice, highlights different ideas to help bridge the gap between clinical research and clinical practice, and notes recent innovations that help make research-practice integration feasible. The articles consider how to break down the barriers to enhance researcher-practitioner dialogue, as well as how to make ongoing outcome assessment feasible for clinicians. Moreover, the articles address how to promote training in evidence-based practice, and how to translate efficacy research into clinical practice and clinical insight into empirical study to better establish a two-way bridge between research and practice. Ultimately, we hope this series can speak to many different types of psychologists, whether they work mainly as researchers or practitioners, so they can see new ways to integrate and learn from both research and practice. PsycINFO Database Record (c) 2012 APA, all rights reserved.

  10. 76 FR 24974 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2011-05-03

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... following four panels of the Joint Biomedical Laboratory Research and Development and Clinical Science... 5, 2011..... 6 p.m.-10 p.m.... Crowne Plaza DC/Silver Spring. Medicine. June 6, 2011..... 8 a.m.-5 p...

  11. European clinical guidelines for Tourette Syndrome and other tic disorders. Part I : assessment

    NARCIS (Netherlands)

    Cath, Danielle C.; Hedderly, Tammy; Ludolph, Andrea G.; Stern, Jeremy S.; Murphy, Tara; Hartmann, Andreas; Czernecki, Virginie; Robertson, Mary May; Martino, Davide; Munchau, A.; Rizzo, R.

    A working group of the European Society for the Study of Tourette Syndrome (ESSTS) has developed the first European assessment guidelines of Tourette Syndrome (TS). The available literature including national guidelines was thoroughly screened and extensively discussed in the expert group of ESSTS

  12. CHANDA and ERINDA: Joint European programs for research on safety of nuclear facilities and waste reduction

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, Roland; Hannaske, Roland; Koegler, Toni [Institut fuer Strahlenphysik, Helmholtz Zentrum DD-Rossendorf, 01328 Dresden (Germany); Institut fuer Kern- und Teilchenphysik, TU Dresden, 01069 Dresden (Germany); Grosse, Eckart [Institut fuer Kern- und Teilchenphysik, TU Dresden, 01069 Dresden (Germany); Junghans, Arnd R. [Institut fuer Strahlenphysik, Helmholtz Zentrum DD-Rossendorf, 01328 Dresden (Germany)

    2014-07-01

    In spite of the planned termination of the German nuclear power program neutron beam facilities in Germany can contribute considerably to research studies on the reduction of hazards due to nuclear waste. Transnational research programs support EU groups who want to carry out projects at the new tof set-up nELBE at HZDR, the calibrated n-flux at PTB and the FRANZ accelerator under construction at Frankfurt. Vice versa various facilities in the EU offer beams for transmutation and safety related studies with neutrons to German scientists under support by ERINDA (2011-2013) and CHANDA (2014-2017; solving challenges in nuclear data for the safety of European nuclear facilities). For work in that field scientific visits are also fostered to improve the exchange of experience between the partners (13 and in future about 35 from 18 countries). Plans for new projects as well as results obtained so far are discussed, and special emphasis is given to the present research performed at nELBE on neutron scattering and absorption.

  13. Do the American Society of Clinical Oncology Value Framework and the European Society of Medical Oncology Magnitude of Clinical Benefit Scale Measure the Same Construct of Clinical Benefit?

    Science.gov (United States)

    Cheng, Sierra; McDonald, Erica J; Cheung, Matthew C; Arciero, Vanessa S; Qureshi, Mahin; Jiang, Di; Ezeife, Doreen; Sabharwal, Mona; Chambers, Alexandra; Han, Dolly; Leighl, Natasha; Sabarre, Kelley-Anne; Chan, Kelvin K W

    2017-08-20

    Purpose Whether the ASCO Value Framework and the European Society for Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale (MCBS) measure similar constructs of clinical benefit is unclear. It is also unclear how they relate to quality-adjusted life-years (QALYs) and funding recommendations in the United Kingdom and Canada. Methods Randomized clinical trials of oncology drug approvals by the US Food and Drug Administration, European Medicines Agency, and Health Canada between 2006 and August 2015 were identified and scored using the ASCO version 1 (v1) framework, ASCO version 2 (v2) framework, and ESMO-MCBS by at least two independent reviewers. Spearman correlation coefficients were calculated to assess construct (between frameworks) and criterion validity (against QALYs from the National Institute for Health and Care Excellence [NICE] and the pan-Canadian Oncology Drug Review [pCODR]). Associations between scores and NICE/pCODR recommendations were examined. Inter-rater reliability was assessed using intraclass correlation coefficients. Results From 109 included randomized clinical trials, 108 ASCOv1, 111 ASCOv2, and 83 ESMO scores were determined. Correlation coefficients for ASCOv1 versus ESMO, ASCOv2 versus ESMO, and ASCOv1 versus ASCOv2 were 0.36 (95% CI, 0.15 to 0.54), 0.17 (95% CI, -0.06 to 0.37), and 0.50 (95% CI, 0.35 to 0.63), respectively. Compared with NICE QALYs, correlation coefficients were 0.45 (ASCOv1), 0.53 (ASCOv2), and 0.46 (ESMO); with pCODR QALYs, coefficients were 0.19 (ASCOv1), 0.20 (ASCOv2), and 0.36 (ESMO). None of the frameworks were significantly associated with NICE/pCODR recommendations. Inter-rater reliability was good for all frameworks. Conclusion The weak-to-moderate correlations of the ASCO frameworks with the ESMO-MCBS, as well as their correlations with QALYs and with NICE/pCODR funding recommendations, suggest different constructs of clinical benefit measured. Construct convergent validity with the ESMO-MCBS did not

  14. [Application of Delphi method in traditional Chinese medicine clinical research].

    Science.gov (United States)

    Bi, Ying-fei; Mao, Jing-yuan

    2012-03-01

    In recent years, Delphi method has been widely applied in traditional Chinese medicine (TCM) clinical research. This article analyzed the present application situation of Delphi method in TCM clinical research, and discussed some problems presented in the choice of evaluation method, classification of observation indexes and selection of survey items. On the basis of present application of Delphi method, the author analyzed the method on questionnaire making, selection of experts, evaluation of observation indexes and selection of survey items. Furthermore, the author summarized the steps of application of Delphi method in TCM clinical research.

  15. Clinical Research Informatics: Recent Advances and Future Directions.

    Science.gov (United States)

    Dugas, M

    2015-08-13

    To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions. Survey of advances, open problems and opportunities in this field based on exploration of current literature. Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/ recruitment and clinical trial execution. CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI.

  16. Women in EPOS: the role of women in a large pan-European Research Infrastructure for Solid Earth sciences

    Science.gov (United States)

    Calignano, Elisa; Freda, Carmela; Baracchi, Laura

    2017-04-01

    Women are outnumbered by men in geosciences senior research positions, but what is the situation if we consider large pan-European Research Infrastructures? With this contribution we want to show an analysis of the role of women in the implementation of the European Plate Observing System (EPOS): a planned research infrastructure for European Solid Earth sciences, integrating national and transnational research infrastructures to enable innovative multidisciplinary research. EPOS involves 256 national research infrastructures, 47 partners (universities and research institutes) from 25 European countries and 4 international organizations. The EPOS integrated platform demands significant coordination between diverse solid Earth disciplinary communities, national research infrastructures and the policies and initiatives they drive, geoscientists and information technologists. The EPOS architecture takes into account governance, legal, financial and technical issues and is designed so that the enterprise works as a single, but distributed, sustainable research infrastructure. A solid management structure is vital for the successful implementation and sustainability of EPOS. The internal organization relies on community-specific Working Packages (WPs), Transversal WPs in charge of the overall EPOS integration and implementation, several governing, executive and advisory bodies, a Project Management Office (PMO) and the Project Coordinator. Driven by the timely debate on gender balance and commitment of the European Commission to promote gender equality in research and innovation, we decided to conduct a mapping exercise on a project that crosses European national borders and that brings together diverse geoscience disciplines under one management structure. We present an analysis of women representation in decision-making positions in each EPOS Working Package (WP Leader, proxy, legal, financial and IT contact persons), in the Boards and Councils and in the PMO

  17. Challenges in Measuring Benefit of Clinical Research Training Programs – the ASH Clinical Research Training Institute Example

    OpenAIRE

    Sung, Lillian; Crowther, Mark; Byrd, John; Gitlin, Scott; Basso, Joe; Burns, Linda

    2015-01-01

    The American Society of Hematology developed the Clinical Research Training Institute (CRTI) to address the lack of training in patient oriented research among hematologists. As the program continues, we need to consider metrics for measuring the benefits of such a training program. This article addresses the benefits of clinical research training programs. The fundamental and key components are education and mentorship. However, there are several other benefits including promotion of collabo...

  18. Extension of the primary care research object model (PCROM) as clinical research information model (CRIM) for the "learning healthcare system".

    Science.gov (United States)

    Kuchinke, Wolfgang; Karakoyun, Töresin; Ohmann, Christian; Arvanitis, Theodoros N; Taweel, Adel; Delaney, Brendan C; Speedie, Stuart M

    2014-12-18

    Patient data from general practices is already used for many types of epidemiological research and increasingly, primary care systems to facilitate randomized clinical trials. The EU funded project TRANSFoRm aims to create a "Learning Healthcare System" at a European level that is able to support all types of research using primary care data, to recruit patients and follow patients in clinical studies and to improve diagnosis and therapy. The implementation of such a Learning Healthcare System needs an information model for clinical research (CRIM), as an informational backbone to integrate aspects of primary care with clinical trials and database searches. Workflow descriptions and corresponding data objects of two clinical use cases (Gastro-Oesophageal Reflux Disease and Type 2 Diabetes) were described in UML activity diagrams. The components of activity diagrams were mapped to information objects of PCROM (Primary Care Research Object Model) and BRIDG (Biomedical Research Integrated Domain Group) and evaluated. The class diagram of PCROM was adapted to comply with workflow descriptions. The suitability of PCROM, a primary care information model already used for clinical trials, to act as an information model for TRANSFoRm was evaluated and resulted in its extension with 14 new information object types, two extensions of existing objects and the introduction of two new high-ranking concepts (CARE area and ENTRY area). No PCROM component was redundant. Our result illustrates that in primary care based research an important but underestimated portion of research activity takes place in the area of care (e.g. patient consultation, screening, recruitment and response to adverse events). The newly introduced CARE area for care-related research activities accounts for this shift and includes Episode of Care and Encounter as two new basic elements. In the ENTRY area different aspects of data collection were combined, including data semantics for observations, assessment

  19. Integrating Bioethics into Clinical and Translational Science Research: A Roadmap

    Science.gov (United States)

    Shapiro, Robyn S.; Layde, Peter M.

    2008-01-01

    Abstract Recent initiatives to improve human health emphasize the need to effectively and appropriately translate new knowledge gleaned from basic biomedical and behavioral research to clinical and community application. To maximize the beneficial impact of scientific advances in clinical practice and community health, and to guard against potential deleterious medical and societal consequences of such advances, incorporation of bioethics at each stage of clinical and translational science research is essential. At the earliest stage, bioethics input is critical to address issues such as whether to limit certain areas of scientific inquiry. Subsequently, bioethics input is important to assure not only that human subjects trials are conducted and reported responsibly, but also that results are incorporated into clinical and community practices in a way that promotes and protects bioethical principles. At the final stage of clinical and translational science research, bioethics helps to identify the need and approach for refining clinical practices when safety or other concerns arise. The framework we present depicts how bioethics interfaces with each stage of clinical and translational science research, and suggests an important research agenda for systematically and comprehensively assuring bioethics input into clinical and translational science initiatives. PMID:20443821

  20. The Challenges of Clinical Researches in Iranian Traditional Medicine (ITM).

    Science.gov (United States)

    Tabarrai, Malihe; Qaraaty, Marzie; Aliasl, Jale

    2016-05-01

    Traditional medicine is one of the medical schools, which has been considered in recent years. Achieving reliable and valid research in ITM is very important to introduce this line of medicine into the healthcare organizations. The aim of this study was to investigate clinical research issues in ITM. This study is a qualitative research. We formed an expert panel and, after identifying the content, the study findings were divided into two main categories. Challenges of clinical research studies are divided into two major categories in ITM, the problems of clinical trial processes and the difficulties in publishing research results. Lack of standard data collection instruments and questionnaires, limited sample size, lack of study models designed for distemperament treatment, unawareness, and non-compliance of ethics committees in facilities approved by WHO for clinical research of TM, and even rigidity beyond conventional medicine studies are some of the previously mentioned issues. Some difficulties in the publication of research results include lack of specialized journals especially at high academic levels, lack of familiarity with editorial board and difficulty in publishing the results of studies that are designed with combined products. A few proposals for these problems include: Conducting codification questionnaire workshops (approved by a thesis assistant with a subject of research tools)Introducing appropriate methods of multi-intervention research in ITMCreating the database of similarly performed research available for researchersDesigning multicenter researchCollaborations between academic centersLinking two or more thesis assistants or research projects in the form of a joint proposal with larger sample sizesEstablishing joint meeting between researchers, the heads of TM research centers and ethics committeesDedicated TM journal. Considering a history of several thousand years, the Iranian traditional medicine is a great venue for students. To