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Sample records for es ii predictions

  1. Phenology prediction component of GypsES

    Science.gov (United States)

    Jesse A. Logan; Lukas P. Schaub; F. William Ravlin

    1991-01-01

    Prediction of phenology is an important component of most pest management programs, and considerable research effort has been expended toward development of predictive tools for gypsy moth phenology. Although phenological prediction is potentially valuable for timing of spray applications (e.g. Bt, or Gypcheck) and other management activities (e.g. placement and...

  2. MHC Class II epitope predictive algorithms

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lund, Ole; Buus, S

    2010-01-01

    Major histocompatibility complex class II (MHC-II) molecules sample peptides from the extracellular space, allowing the immune system to detect the presence of foreign microbes from this compartment. To be able to predict the immune response to given pathogens, a number of methods have been...... developed to predict peptide-MHC binding. However, few methods other than the pioneering TEPITOPE/ProPred method have been developed for MHC-II. Despite recent progress in method development, the predictive performance for MHC-II remains significantly lower than what can be obtained for MHC-I. One reason...

  3. Les revistes bilingües a la Tortosa de la II República

    Directory of Open Access Journals (Sweden)

    M. Carme Gombau Domingo

    2016-06-01

    Full Text Available En l’àmbit de la premsa tortosina en català del primer terç del segle xx es donen dues actituds lingüístiques: la fabriana i la tortosinista. La primera, partidària del model de llengua de l’IEC, era minoritària als anys vint però es generalitza a partir dels anys trenta (La Veu de Tortosa, La Veu Comarcal, Ara, Acció, Vida Tortosina i Lluita; mentre que el tortosinisme, que es correspon amb una ideologia cada cop més localista i que eleva el «parlar tortosí» a la categoria de llengua, queda reduït durant la II República a tres revistes bilingües: La Zuda, Germanor i La Santa Cinta. There were two linguistic actitudes in the tortosine press of the first third in the 20th century: the fabriana amb the tortosinista. The fabriana, in favour of the IEC linguistic model, was in minority during the 20’s, but it became widespread from the 30’s (La Veu de Tortosa, La Veu Comarcal, Ara, Acció, Vida Tortosina i Lluita. The second, the tortosinista, had a local ideology and compared the tortosinisme talk as a complet language, but it was reduced during the ii Republic to three magazines: La Zuda, Germanor i La Santa Cinta.

  4. Pretest Predictions for Phase II Ventilation Tests

    International Nuclear Information System (INIS)

    Yiming Sun

    2001-01-01

    The objective of this calculation is to predict the temperatures of the ventilating air, waste package surface, and concrete pipe walls that will be developed during the Phase II ventilation tests involving various test conditions. The results will be used as inputs to validating numerical approach for modeling continuous ventilation, and be used to support the repository subsurface design. The scope of the calculation is to identify the physical mechanisms and parameters related to thermal response in the Phase II ventilation tests, and describe numerical methods that are used to calculate the effects of continuous ventilation. The calculation is limited to thermal effect only. This engineering work activity is conducted in accordance with the ''Technical Work Plan for: Subsurface Performance Testing for License Application (LA) for Fiscal Year 2001'' (CRWMS M and O 2000d). This technical work plan (TWP) includes an AP-2.21Q, ''Quality Determinations and Planning for Scientific, Engineering, and Regulatory Compliance Activities'', activity evaluation (CRWMS M and O 2000d, Addendum A) that has determined this activity is subject to the YMP quality assurance (QA) program. The calculation is developed in accordance with the AP-3.12Q procedure, ''Calculations''. Additional background information regarding this activity is contained in the ''Development Plan for Ventilation Pretest Predictive Calculation'' (DP) (CRWMS M and O 2000a)

  5. Use of APACHE II and SAPS II to predict mortality for hemorrhagic and ischemic stroke patients.

    Science.gov (United States)

    Moon, Byeong Hoo; Park, Sang Kyu; Jang, Dong Kyu; Jang, Kyoung Sool; Kim, Jong Tae; Han, Yong Min

    2015-01-01

    We studied the applicability of the Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) in patients admitted to the intensive care unit (ICU) with acute stroke and compared the results with the Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS). We also conducted a comparative study of accuracy for predicting hemorrhagic and ischemic stroke mortality. Between January 2011 and December 2012, ischemic or hemorrhagic stroke patients admitted to the ICU were included in the study. APACHE II and SAPS II-predicted mortalities were compared using a calibration curve, the Hosmer-Lemeshow goodness-of-fit test, and the receiver operating characteristic (ROC) curve, and the results were compared with the GCS and NIHSS. Overall 498 patients were included in this study. The observed mortality was 26.3%, whereas APACHE II and SAPS II-predicted mortalities were 35.12% and 35.34%, respectively. The mean GCS and NIHSS scores were 9.43 and 21.63, respectively. The calibration curve was close to the line of perfect prediction. The ROC curve showed a slightly better prediction of mortality for APACHE II in hemorrhagic stroke patients and SAPS II in ischemic stroke patients. The GCS and NIHSS were inferior in predicting mortality in both patient groups. Although both the APACHE II and SAPS II systems can be used to measure performance in the neurosurgical ICU setting, the accuracy of APACHE II in hemorrhagic stroke patients and SAPS II in ischemic stroke patients was superior. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Structural properties of MHC class II ligands, implications for the prediction of MHC class II epitopes.

    Directory of Open Access Journals (Sweden)

    Kasper Winther Jørgensen

    2010-12-01

    Full Text Available Major Histocompatibility class II (MHC-II molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule, allowing binding of peptides extending out of the binding groove. Furthermore, only a few HLA-DR alleles have been characterized with a sufficient number of peptides (100-200 peptides per allele to derive accurate description of their binding motif. Little work has been performed characterizing structural properties of MHC class II ligands. Here, we perform one such large-scale analysis. A large set of SYFPEITHI MHC class II ligands covering more than 20 different HLA-DR molecules was analyzed in terms of their secondary structure and surface exposure characteristics in the context of the native structure of the corresponding source protein. We demonstrated that MHC class II ligands are significantly more exposed and have significantly more coil content than other peptides in the same protein with similar predicted binding affinity. We next exploited this observation to derive an improved prediction method for MHC class II ligands by integrating prediction of MHC- peptide binding with prediction of surface exposure and protein secondary structure. This combined prediction method was shown to significantly outperform the state-of-the-art MHC class II peptide binding prediction method when used to identify MHC class II ligands. We also tried to integrate N- and O-glycosylation in our prediction methods but this additional information was found not to improve prediction performance. In summary, these findings strongly suggest that local structural properties influence antigen processing and/or the accessibility of peptides to the MHC class II molecule.

  7. Predictive Models and Computational Toxicology (II IBAMTOX)

    Science.gov (United States)

    EPA’s ‘virtual embryo’ project is building an integrative systems biology framework for predictive models of developmental toxicity. One schema involves a knowledge-driven adverse outcome pathway (AOP) framework utilizing information from public databases, standardized ontologies...

  8. Compressor Part II: Volute Flow Predictions

    Directory of Open Access Journals (Sweden)

    Yu-Tai Lee

    1999-01-01

    Full Text Available A numerical method that solves the Reynolds-averaged Navier-Stokes equations is used to study an inefficient component of a shipboard air-conditioning HCFC-124 compressor system. This high-loss component of the centrifugal compressor was identified as the volute through a series of measurements given in Part I of the paper. The predictions were made using three grid topologies. The first grid closes the connection between the cutwater and the discharge diffuser. The other two grids connect the cutwater area with the discharge diffuser. Experiments were performed to simulate both the cutwater conditions used in the predictions. Surface pressures along the outer wall and near the inlet of the volute were surveyed for comparisons with the predictions. Good agreements between the predicted results and the measurements validate the calculations. Total pressure distributions and flow stream traces from the prediction results support the loss distribution through the volute. A modified volute configuration is examined numerically for further loss comparison.

  9. RADIOEMISSÕES SOLARES TIPO II ASSOCIADAS A FLARES E CMES

    Directory of Open Access Journals (Sweden)

    Rafael Douglas Cunha-Silva

    2013-12-01

    Full Text Available Atribuídas a ondas de choque e a ejeções de plasmoide, as emissões solares tipo II são ondaseletromagnéticas geradas a partir de oscilações do plasma coronal. A origem dos choques associados a essasemissões é ainda uma questão em aberto da física solar. Enquanto alguns trabalhos sugerem os flares solarescomo seus acionadores, outros fornecem indícios de serem as ejeções de massa coronal (CMEs sua origemmais provável. Este trabalho apresenta os resultados da análise de duas emissões tipo II, registradas por doisespectrômetros da rede e-CALLISTO (extended-Compound Astronomical Low-cost Low-frequency Instrument forSpectroscopy and Transportable Observatory, os quais operam na faixa de frequências de 45-870 MHz. Oprimeiro evento, observado em 13 de junho de 2010, às 05:38 UT, apresentou uma taxa de deriva em frequênciade -0,2 MHz s-1, correspondente a uma velocidade de choque de 528 km s-1, estando, temporalmente, associadoa uma CME lenta (~320 km s-1 e a um flare solar em raios-X, classe M1.0. O segundo evento, observado em 09de Agosto de 2011, às 08:02 UT, apresentou uma taxa de deriva em frequência de -1,4 MHz s-1, correspondentea uma velocidade de choque de 1375 km s-1, estando, temporalmente, associado a uma CME tipo halo (~1610km s-1 e a um flare solar em raios-X, classe X6.9. Os resultados obtidos, para os parâmetros observacionais dasemissões tipo II e para os parâmetros físicos de suas fontes, são discutidos no contexto de sua relação com seuflares e CMEs associados.

  10. Advances in criticality predictions for EBR-II

    International Nuclear Information System (INIS)

    Schaefer, R.W.; Imel, G.R.

    1994-01-01

    Improvements to startup criticality predictions for the EBR-II reactor have been made. More exact calculational models, methods and data are now used, and better procedures for obtaining experimental data that enter into the prediction are in place. Accuracy improved by more than a factor of two and the largest ECP error observed since the changes is only 18 cents. An experimental method using subcritical counts is also being implemented

  11. A Modified APACHE II Score for Predicting Mortality of Variceal ...

    African Journals Online (AJOL)

    Conclusion: Modified APACHE II score is effective in predicting outcome of patients with variceal bleeding. Score of L 15 points and long ICU stay are associated with high mortality. Keywords: liver cirrhosis, periportal fibrosis, portal hypertension, schistosomiasis udan Journal of Medical Sciences Vol. 2 (2) 2007: pp. 105- ...

  12. Motivations to participate in a Phase I/II HIV vaccine trial: A descriptive study from Dar es Salaam, Tanzania

    Directory of Open Access Journals (Sweden)

    E. A. M. Tarimo

    2016-02-01

    Full Text Available Abstract Background The search for an efficacious HIV vaccine is a global priority. To date only one HIV vaccine trial (RV144 has shown modest efficacy in a phase III trial. With existing different HIV-1 subtypes and frequent mutations, multiple trials are needed from different geographical sites particularly in sub-Saharan Africa where most HIV infections occur. Thus, motivations to participate in HIV vaccine trials among Tanzanians need to be assessed. This paper describes the motives of Police Officers who showed great interest to volunteer in HIVIS-03 in Dar es Salaam, Tanzania. Methods A descriptive cross-sectional study was conducted among Police Officers who showed interest to participate in the HIVIS-03, a phase I/II HIV vaccine trial in Dar es Salaam. Prior to detailed training sessions about HIV vaccine trials, the potential participants narrated their individual motives to participate in the trial on a piece of paper. Descriptive analysis using content approach and frequency distributions were performed. Results Of the 265 respondents, 242 (91.3 % provided their socio-demographic characteristics as well as reasons that would make them take part in the proposed trial. Majority, (39.7 %, cited altruism as the main motive. Women were more likely to volunteer due to altruism compared to men (P < 0.01. Researchers’ explanations about HIV/AIDS vaccine studies motivated 15.3 %. More men (19.6 % than women (1.7 % were motivated to volunteer due to researchers’ explanations (P < 0.001. Also, compared to other groups, those unmarried and educated up to secondary level of education were motivated to volunteer due to researchers’ explanation (P < 0.05. Other reasons were: desire to become a role model (18.6 %; to get knowledge for educating others (14.0 %; to cooperate with researchers in developing an HIV vaccine (9.5 %; to get protection against HIV infection (7.0 %, and severity of the disease within families (6.2

  13. Predictive value of SAPS II and APACHE II scoring systems for patient outcome in a medical intensive care unit

    Directory of Open Access Journals (Sweden)

    Amina Godinjak

    2016-11-01

    Full Text Available Objective. The aim is to determine SAPS II and APACHE II scores in medical intensive care unit (MICU patients, to compare them for prediction of patient outcome, and to compare with actual hospital mortality rates for different subgroups of patients. Methods. One hundred and seventy-four patients were included in this analysis over a oneyear period in the MICU, Clinical Center, University of Sarajevo. The following patient data were obtained: demographics, admission diagnosis, SAPS II, APACHE II scores and final outcome. Results. Out of 174 patients, 70 patients (40.2% died. Mean SAPS II and APACHE II scores in all patients were 48.4±17.0 and 21.6±10.3 respectively, and they were significantly different between survivors and non-survivors. SAPS II >50.5 and APACHE II >27.5 can predict the risk of mortality in these patients. There was no statistically significant difference in the clinical values of SAPS II vs APACHE II (p=0.501. A statistically significant positive correlation was established between the values of SAPS II and APACHE II (r=0.708; p=0.001. Patients with an admission diagnosis of sepsis/septic shock had the highest values of both SAPS II and APACHE II scores, and also the highest hospital mortality rate of 55.1%. Conclusion. Both APACHE II and SAPS II had an excellent ability to discriminate between survivors and non-survivors. There was no significant difference in the clinical values of SAPS II and APACHE II. A positive correlation was established between them. Sepsis/septic shock patients had the highest predicted and observed hospital mortality rate.

  14. Complex-wide review of DOE's Low-Level Waste Management ES ampersand H vulnerabilities. Volume II. Final report

    International Nuclear Information System (INIS)

    1996-05-01

    Volume I of this report presents a summary of DOE's complex-wide review of its low-level waste management system, including the assessment scope and methodology, site-specific and complex-wide vulnerabilities, and DOE's conclusions and recommendations. Volume II presents a more detailed discussion of the assessment methodology and evaluation instruments developed by the Assessment Working Group for identifying site-specific vulnerabilities, categorizing and classifying vulnerabilities, and identifying and analyzing complex-wide vulnerabilities. Attachments A and B of this volume contain, respectively, the Site Evaluation Survey and the Vulnerability Assessment Form used in those processes. Volume III contains the site-specific assessment reports for the 36 sites (38 facilities) assessed in the complex-wide review from which the complex-wide vulnerabilities were drawn

  15. Peak-summer East Asian rainfall predictability and prediction part II: extratropical East Asia

    Science.gov (United States)

    Yim, So-Young; Wang, Bin; Xing, Wen

    2016-07-01

    The part II of the present study focuses on northern East Asia (NEA: 26°N-50°N, 100°-140°E), exploring the source and limit of the predictability of the peak summer (July-August) rainfall. Prediction of NEA peak summer rainfall is extremely challenging because of the exposure of the NEA to midlatitude influence. By examining four coupled climate models' multi-model ensemble (MME) hindcast during 1979-2010, we found that the domain-averaged MME temporal correlation coefficient (TCC) skill is only 0.13. It is unclear whether the dynamical models' poor skills are due to limited predictability of the peak-summer NEA rainfall. In the present study we attempted to address this issue by applying predictable mode analysis method using 35-year observations (1979-2013). Four empirical orthogonal modes of variability and associated major potential sources of variability are identified: (a) an equatorial western Pacific (EWP)-NEA teleconnection driven by EWP sea surface temperature (SST) anomalies, (b) a western Pacific subtropical high and Indo-Pacific dipole SST feedback mode, (c) a central Pacific-El Nino-Southern Oscillation mode, and (d) a Eurasian wave train pattern. Physically meaningful predictors for each principal component (PC) were selected based on analysis of the lead-lag correlations with the persistent and tendency fields of SST and sea-level pressure from March to June. A suite of physical-empirical (P-E) models is established to predict the four leading PCs. The peak summer rainfall anomaly pattern is then objectively predicted by using the predicted PCs and the corresponding observed spatial patterns. A 35-year cross-validated hindcast over the NEA yields a domain-averaged TCC skill of 0.36, which is significantly higher than the MME dynamical hindcast (0.13). The estimated maximum potential attainable TCC skill averaged over the entire domain is around 0.61, suggesting that the current dynamical prediction models may have large rooms to improve

  16. NOVAS APLICAÇÕES DE SISTEMAS SFE" HOME MADE".: II. PLANTAS DA AMÉRICA DO SUL

    Directory of Open Access Journals (Sweden)

    Fernando M. LANÇAS

    1997-12-01

    Full Text Available O Laboratório de Cromatografia do IQSC-USP tem desenvolvido pesquisas em conjunto com outros grupos de pesquisa do Brasil e da América Latina, visando a futura implantação da SFE (extração com fluido supercrítico nestes laboratórios. No presente trabalho, apresenta-se alguns dos resultados obtidos na cooperação com pesquisadores do Chile e da Venezuela, direcionados para a SFE de substâncias de potencial interesse econômico, princípios ativos ou substâncias tóxicas: triglicerídeos, ácidos graxos, flavonóides, alcalóides, etc. Foram estudadas plantas nativas do Chile e da Venezuela, algumas delas nunca estudadas por métodos fitoquímicos convencionais e pertencentes a várias famílias vegetais: Leguminosae, Chrysobalanaceae, Annonnaceae, etc. O uso da SFE em conjunto com CGAR-EM (cromatografia gasosa de alta resolução - espectrometria de massas ou CLAE-DAD (cromatografia líquida de alta eficiência com detector" photodiodearray" permitiu a identificação de algumas substâncias presentes em baixa concentração, a partir de pequenas quantidades de material vegetal; estes dados são de grande importância para a caracterização química das espécies estudadas.Further applications of "home made" SFE systems. II. South American plants. The Laboratório de Cromatografia, IQSC-USP, has been developing joint research projects with other research groups from Brazil and Latin America, aiming a future implementation of SFE (supercritical fluid extraction in these laboratories. In the present work, some of the results obtained in the cooperation with researchers from Chile and Venezuela, focused to SFE of potential economical interest compounds, active compounds or toxic molecules, are presented: triglycerides, fatty acids, flavonoids, alkaloids, etc. Native plants from Chile and Venezuela, belonging to several families (Leguminosae, Chrysobalanaceae, Annonnaceae, etc. were studied, some of them never studied by conventional

  17. Modeling transducer impulse responses for predicting calibrated pressure pulses with the ultrasound simulation program Field II

    DEFF Research Database (Denmark)

    Bæk, David; Jensen, Jørgen Arendt; Willatzen, Morten

    2010-01-01

    FIELD II is a simulation software capable of predicting the field pressure in front of transducers having any complicated geometry. A calibrated prediction with this program is, however, dependent on an exact voltage-to-surface acceleration impulse response of the transducer. Such impulse response...... is not calculated by FIELD II. This work investigates the usability of combining a one-dimensional multilayer transducer modeling principle with the FIELD II software. Multilayer here refers to a transducer composed of several material layers. Measurements of pressure and current from Pz27 piezoceramic disks...... transducer model and the FIELD II software in combination give good agreement with measurements....

  18. Extreme Environment Damage Index and Accumulation Model for CMC Laminate Fatigue Life Prediction, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Materials Research & Design (MR&D) is proposing in the SBIR Phase II an effort to develop a tool for predicting the fatigue life of C/SiC composite...

  19. SOX9 Expression Predicts Relapse of Stage II Colon Cancer Patients

    DEFF Research Database (Denmark)

    Espersen, Maiken Lise Marcker; Linnemann, Dorte; Christensen, Ib Jarle

    2016-01-01

    The aim of this study was to investigate if the protein expression of Sex-determining region y-box 9 (SOX9) in primary tumors could predict relapse of stage II colon cancer patients.144 patients with stage II primary colon cancer were retrospectively enrolledin the study. SOX9 expression...

  20. Robust Prediction of High Lift Using Surface Vorticity, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — FlightStream has been developed a fast, accurate, aerodynamic prediction code based on vorticity computations on the surface of an aircraft. The code, though still a...

  1. Chaotic time series. Part II. System Identification and Prediction

    Directory of Open Access Journals (Sweden)

    Bjørn Lillekjendlie

    1994-10-01

    Full Text Available This paper is the second in a series of two, and describes the current state of the art in modeling and prediction of chaotic time series. Sample data from deterministic non-linear systems may look stochastic when analysed with linear methods. However, the deterministic structure may be uncovered and non-linear models constructed that allow improved prediction. We give the background for such methods from a geometrical point of view, and briefly describe the following types of methods: global polynomials, local polynomials, multilayer perceptrons and semi-local methods including radial basis functions. Some illustrative examples from known chaotic systems are presented, emphasising the increase in prediction error with time. We compare some of the algorithms with respect to prediction accuracy and storage requirements, and list applications of these methods to real data from widely different areas.

  2. Monolayer II-VI semiconductors: A first-principles prediction

    Science.gov (United States)

    Zheng, Hui; Chen, Nian-Ke; Zhang, S. B.; Li, Xian-Bin

    A systematic study of 32 honeycomb monolayer II-VI semiconductors is carried out by first-principles methods. It appears that BeO, MgO, CaO, ZnO, CdO, CaS, SrS, SrSe, BaTe, and HgTe honeycomb monolayers have a good dynamic stability which is revealed by phonon calculations. In addition, from the molecular dynamic (MD) simulation of other unstable candidates, we also find two extra monolayers dynamically stable, which are tetragonal BaS and orthorhombic HgS. The honeycomb monolayers exist in form of either a planar perfect honeycomb or a low-buckled 2D layer, all of which possess a band gap and most of them are in the ultraviolet region. Interestingly, the dynamically stable SrSe has a gap near visible light, and displays exotic electronic properties with a flat top of the valence band, and hence has a strong spin polarization upon hole doping. The honeycomb HgTe has been reported to achieve a topological nontrivial phase under appropriate in-plane tensile strain and spin-orbital coupling (SOC). Some II-VI partners with less than 5% lattice mismatch may be used to design novel 2D heterojunction devices. If synthesized, potential applications of these 2D II-VI families could include optoelectronics, spintronics, and strong correlated electronics. Distinguished Student (DS) Program of APS FIP travel funds.

  3. Predicted continuum spectra of type II supernovae - LTE results

    Science.gov (United States)

    Shaviv, G.; Wehrse, R.; Wagoner, R. V.

    1985-01-01

    The continuum spectral energy distribution of the flux emerging from type II supernovae is calculated from quasi-static radiative transfer through a power-law density gradient, assuming radiative equilibrium and LTE. It is found that the Balmer jump disappears at high effective temperatures and low densities, while the spectrum resembles that of a dilute blackbody but is flatter with a sharper cutoff at the short-wavelength end. A significant UV excess is found in all models calculated. The calculation should be considered exploratory because of significant effects which are anticipated to arise from departure from LTE.

  4. Validation of CRIB II for prediction of mortality in premature babies.

    Science.gov (United States)

    Rastogi, Pallav Kumar; Sreenivas, V; Kumar, Nirmal

    2010-02-01

    Validation of Clinical Risk Index for Babies (CRIB II) score in predicting the neonatal mortality in preterm neonates < or = 32 weeks gestational age. Prospective cohort study. Tertiary care neonatal unit. 86 consecutively born preterm neonates with gestational age < or = 32 weeks. The five variables related to CRIB II were recorded within the first hour of admission for data analysis. The receiver operating characteristics (ROC) curve was used to check the accuracy of the mortality prediction. HL Goodness of fit test was used to see the discrepancy between observed and expected outcomes. A total of 86 neonates (males 59.6% mean birthweight: 1228 +/- 398 grams; mean gestational age: 28.3 +/- 2.4 weeks) were enrolled in the study, of which 17 (19.8%) left hospital against medical advice (LAMA) before reaching the study end point. Among 69 neonates completing the study, 24 (34.8%) had adverse outcome during hospital stay and 45 (65.2%) had favorable outcome. CRIB II correctly predicted adverse outcome in 90.3% (Hosmer Lemeshow goodness of fit test P=0.6). Area under curve (AUC) for CRIB II was 0.9032. In intention to treat analysis with LAMA cases included as survivors, the mortality prediction was 87%. If these were included as having died then mortality prediction was 83.1%. The CRIB II score was found to be a good predictive instrument for mortality in preterm infants < or = 32 weeks gestation.

  5. The evaluation of CRIB II scoring system in predicting mortality in preterm newborns

    Directory of Open Access Journals (Sweden)

    Homa Babaei

    2015-02-01

    Full Text Available Background: The survival rate of premature newborns depends on gestational age, birth weight and condition when they are hospitalized. Different scoring systems to predict mortality in newborns has been designed. The purpose of this study was to evaluate value of CRIB II scoring system in predicting mortality rate of infants with birth weights less than 1500 grams. Material and Methods: In this 8 month cross - sectional study (September 2010 to April 2010 which was conducted in the NICU of Imam Reza hospital in Kermanshah, preterm newborns with birth weight less than 1500 gr and gestational age less than 32 weeks who were admitted within 12 hours after birth in the NICU ,were evaluated based on CRIB II scoring system . Results: 50 neonates out of 1360 (36.8% survived and 86 neonates(63.2% died. Average CRIB II score in newborn survived was 5.8±2.9 and in infants died was 9.8±2.9 (p <0.0001. Based on the AUC, the CRIB II score could predict about 0.85 (CI: 0.77-0.92 of mortality. Also based on the ROC curve cut-off point for scoring CRIB II, was 6.5. Conclusion: Our study showed that CRIB II has a high value( about %85 in predicting mortality in newborns with birth weights less than 1500 grams.

  6. Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lundegaard, Claus; Worning, Peder

    2004-01-01

    Prediction of which peptides will bind a specific major histocompatibility complex (MHC) constitutes an important step in identifying potential T-cell epitopes suitable as vaccine candidates. MHC class II binding peptides have a broad length distribution complicating such predictions. Thus......, identifying the correct alignment is a crucial part of identifying the core of an MHC class II binding motif. In this context, we wish to describe a novel Gibbs motif sampler method ideally suited for recognizing such weak sequence motifs. The method is based on the Gibbs sampling method, and it incorporates...

  7. In silico prediction of ROCK II inhibitors by different classification approaches.

    Science.gov (United States)

    Cai, Chuipu; Wu, Qihui; Luo, Yunxia; Ma, Huili; Shen, Jiangang; Zhang, Yongbin; Yang, Lei; Chen, Yunbo; Wen, Zehuai; Wang, Qi

    2017-11-01

    ROCK II is an important pharmacological target linked to central nervous system disorders such as Alzheimer's disease. The purpose of this research is to generate ROCK II inhibitor prediction models by machine learning approaches. Firstly, four sets of descriptors were calculated with MOE 2010 and PaDEL-Descriptor, and optimized by F-score and linear forward selection methods. In addition, four classification algorithms were used to initially build 16 classifiers with k-nearest neighbors [Formula: see text], naïve Bayes, Random forest, and support vector machine. Furthermore, three sets of structural fingerprint descriptors were introduced to enhance the predictive capacity of classifiers, which were assessed with fivefold cross-validation, test set validation and external test set validation. The best two models, MFK + MACCS and MLR + SubFP, have both MCC values of 0.925 for external test set. After that, a privileged substructure analysis was performed to reveal common chemical features of ROCK II inhibitors. Finally, binding modes were analyzed to identify relationships between molecular descriptors and activity, while main interactions were revealed by comparing the docking interaction of the most potent and the weakest ROCK II inhibitors. To the best of our knowledge, this is the first report on ROCK II inhibitors utilizing machine learning approaches that provides a new method for discovering novel ROCK II inhibitors.

  8. FORUM - FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology

    Science.gov (United States)

    FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo resp...

  9. Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model

    Directory of Open Access Journals (Sweden)

    Mittelmann Hans D

    2010-01-01

    Full Text Available Abstract Background The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a distinct subset of peptides and the enormous number of possible peptide epitopes prevents their complete experimental characterization. Computational methods can utilize the limited experimental data to predict the binding affinities of peptides to class II MHC. Results We have developed the Regularized Thermodynamic Average, or RTA, method for predicting the affinities of peptides binding to class II MHC. RTA accounts for all possible peptide binding conformations using a thermodynamic average and includes a parameter constraint for regularization to improve accuracy on novel data. RTA was shown to achieve higher accuracy, as measured by AUC, than SMM-align on the same data for all 17 MHC allotypes examined. RTA also gave the highest accuracy on all but three allotypes when compared with results from 9 different prediction methods applied to the same data. In addition, the method correctly predicted the peptide binding register of 17 out of 18 peptide-MHC complexes. Finally, we found that suboptimal peptide binding registers, which are often ignored in other prediction methods, made significant contributions of at least 50% of the total binding energy for approximately 20% of the peptides. Conclusions The RTA method accurately predicts peptide binding affinities to class II MHC and accounts for multiple peptide binding registers while reducing overfitting through regularization. The method has potential applications in vaccine design and in understanding autoimmune disorders. A web server implementing the RTA prediction method is available at http://bordnerlab.org/RTA/.

  10. The Impact of EuroSCORE II Risk Factors on Prediction of Long-Term Mortality.

    Science.gov (United States)

    Barili, Fabio; Pacini, Davide; D'Ovidio, Mariangela; Dang, Nicholas C; Alamanni, Francesco; Di Bartolomeo, Roberto; Grossi, Claudio; Davoli, Marina; Fusco, Danilo; Parolari, Alessandro

    2016-10-01

    The European System for Cardiac Operation Risk Evaluation (EuroSCORE) II has not been tested yet for predicting long-term mortality. This study was undertaken to evaluate the relationship between EuroSCORE II and long-term mortality and to develop a new algorithm based on EuroSCORE II factors to predict long-term survival after cardiac surgery. Complete data on 10,033 patients who underwent major cardiac surgery during a 7-year period were retrieved from three prospective institutional databases and linked with the Italian Tax Register Information System. Mortality at follow-up was analyzed with time-to-event analysis. The Kaplan-Meier estimates of survival at 1 and 5 were, respectively, 95.0% ± 0.2% and 84.7% ± 0.4%. Both discrimination and calibration of EuroSCORE II decreased in the prediction of 1-year and 5-year mortality. Nonetheless, EuroSCORE II was confirmed to be an independent predictor of long-term mortality with a nonlinear trend. Several EuroSCORE II variables were independent risk factors for long-term mortality in a regression model, most of all very low ejection fraction (less than 20%), salvage operation, and dialysis. In the final model, isolated mitral valve surgery and isolated coronary artery bypass graft surgery were associated with improved long-term survival. The EuroSCORE II cannot be considered a direct estimator of long-term risk of death, as its performance fades for mortality at follow-up longer than 30 days. Nonetheless, it is nonlinearly associated with long-term mortality, and most of its variables are risk factors for long-term mortality. Hence, they can be used in a different algorithm to stratify the risk of long-term mortality after surgery. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  11. A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds.

    Science.gov (United States)

    DiMasi, J A; Hermann, J C; Twyman, K; Kondru, R K; Stergiopoulos, S; Getz, K A; Rackoff, W

    2015-11-01

    We developed an algorithm (ANDI) for predicting regulatory marketing approval for new cancer drugs after phase II testing has been conducted, with the objective of providing a tool to improve drug portfolio decision-making. We examined 98 oncology drugs from the top 50 pharmaceutical companies (2006 sales) that first entered clinical development from 1999 to 2007, had been taken to at least phase II development, and had a known final outcome (research abandonment or regulatory marketing approval). Data on safety, efficacy, operational, market, and company characteristics were obtained from public sources. Logistic regression and machine-learning methods were used to provide an unbiased approach to assess overall predictability and to identify the most important individual predictors. We found that a simple four-factor model (activity, number of patients in the pivotal phase II trial, phase II duration, and a prevalence-related measure) had high sensitivity and specificity for predicting regulatory marketing approval. © 2015 American Society for Clinical Pharmacology and Therapeutics.

  12. Predictive Modeling of a Paradigm Mechanical Cooling Tower Model: II. Optimal Best-Estimate Results with Reduced Predicted Uncertainties

    Directory of Open Access Journals (Sweden)

    Ruixian Fang

    2016-09-01

    Full Text Available This work uses the adjoint sensitivity model of the counter-flow cooling tower derived in the accompanying PART I to obtain the expressions and relative numerical rankings of the sensitivities, to all model parameters, of the following model responses: (i outlet air temperature; (ii outlet water temperature; (iii outlet water mass flow rate; and (iv air outlet relative humidity. These sensitivities are subsequently used within the “predictive modeling for coupled multi-physics systems” (PM_CMPS methodology to obtain explicit formulas for the predicted optimal nominal values for the model responses and parameters, along with reduced predicted standard deviations for the predicted model parameters and responses. These explicit formulas embody the assimilation of experimental data and the “calibration” of the model’s parameters. The results presented in this work demonstrate that the PM_CMPS methodology reduces the predicted standard deviations to values that are smaller than either the computed or the experimentally measured ones, even for responses (e.g., the outlet water flow rate for which no measurements are available. These improvements stem from the global characteristics of the PM_CMPS methodology, which combines all of the available information simultaneously in phase-space, as opposed to combining it sequentially, as in current data assimilation procedures.

  13. Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms

    Directory of Open Access Journals (Sweden)

    Feng Lin

    2007-11-01

    Full Text Available Abstract Background Peptides binding to Major Histocompatibility Complex (MHC class II molecules are crucial for initiation and regulation of immune responses. Predicting peptides that bind to a specific MHC molecule plays an important role in determining potential candidates for vaccines. The binding groove in class II MHC is open at both ends, allowing peptides longer than 9-mer to bind. Finding the consensus motif facilitating the binding of peptides to a MHC class II molecule is difficult because of different lengths of binding peptides and varying location of 9-mer binding core. The level of difficulty increases when the molecule is promiscuous and binds to a large number of low affinity peptides. In this paper, we propose two approaches using multi-objective evolutionary algorithms (MOEA for predicting peptides binding to MHC class II molecules. One uses the information from both binders and non-binders for self-discovery of motifs. The other, in addition, uses information from experimentally determined motifs for guided-discovery of motifs. Results The proposed methods are intended for finding peptides binding to MHC class II I-Ag7 molecule – a promiscuous binder to a large number of low affinity peptides. Cross-validation results across experiments on two motifs derived for I-Ag7 datasets demonstrate better generalization abilities and accuracies of the present method over earlier approaches. Further, the proposed method was validated and compared on two publicly available benchmark datasets: (1 an ensemble of qualitative HLA-DRB1*0401 peptide data obtained from five different sources, and (2 quantitative peptide data obtained for sixteen different alleles comprising of three mouse alleles and thirteen HLA alleles. The proposed method outperformed earlier methods on most datasets, indicating that it is well suited for finding peptides binding to MHC class II molecules. Conclusion We present two MOEA-based algorithms for finding motifs

  14. Testing the Predictive Validity of the Hendrich II Fall Risk Model.

    Science.gov (United States)

    Jung, Hyesil; Park, Hyeoun-Ae

    2018-03-01

    Cumulative data on patient fall risk have been compiled in electronic medical records systems, and it is possible to test the validity of fall-risk assessment tools using these data between the times of admission and occurrence of a fall. The Hendrich II Fall Risk Model scores assessed during three time points of hospital stays were extracted and used for testing the predictive validity: (a) upon admission, (b) when the maximum fall-risk score from admission to falling or discharge, and (c) immediately before falling or discharge. Predictive validity was examined using seven predictive indicators. In addition, logistic regression analysis was used to identify factors that significantly affect the occurrence of a fall. Among the different time points, the maximum fall-risk score assessed between admission and falling or discharge showed the best predictive performance. Confusion or disorientation and having a poor ability to rise from a sitting position were significant risk factors for a fall.

  15. An evaluation of multigroup flux predictions in the EBR-II core

    International Nuclear Information System (INIS)

    Hill, R.N.; Fanning, T.H.; Finck, P.J.

    1991-01-01

    The unique physics characteristics of EBR-II which are difficult to model with conventional neutronic methodologies are identified; the high neutron leakage fraction and importance of neutron reflection cause errors when conventional calculational approximations are utilized. In this paper, various conventional and higher-order group constant evaluations and flux computation methods are compared for a simplified R-Z model of the EBR-II system. Although conventional methods do provide adequate predictions of the flux in the core region, significant mispredictions are observed in the reflector and radial blanket regions. Calculational comparisons indicate that a fine energy group structure is required for accurate predictions of the eigenvalue and flux distribution; greater detail is needed in the iron resonance scattering treatment. Calculational comparisons also indicate that transport theory with detailed anisotropic scattering treatment is required

  16. An evaluation of multigroup flux predictions in the EBR-II core

    Energy Technology Data Exchange (ETDEWEB)

    Hill, R.N.; Fanning, T.H.; Finck, P.J.

    1991-12-31

    The unique physics characteristics of EBR-II which are difficult to model with conventional neutronic methodologies are identified; the high neutron leakage fraction and importance of neutron reflection cause errors when conventional calculational approximations are utilized. In this paper, various conventional and higher-order group constant evaluations and flux computation methods are compared for a simplified R-Z model of the EBR-II system. Although conventional methods do provide adequate predictions of the flux in the core region, significant mispredictions are observed in the reflector and radial blanket regions. Calculational comparisons indicate that a fine energy group structure is required for accurate predictions of the eigenvalue and flux distribution; greater detail is needed in the iron resonance scattering treatment. Calculational comparisons also indicate that transport theory with detailed anisotropic scattering treatment is required.

  17. An evaluation of multigroup flux predictions in the EBR-II core

    Energy Technology Data Exchange (ETDEWEB)

    Hill, R.N.; Fanning, T.H.; Finck, P.J.

    1991-01-01

    The unique physics characteristics of EBR-II which are difficult to model with conventional neutronic methodologies are identified; the high neutron leakage fraction and importance of neutron reflection cause errors when conventional calculational approximations are utilized. In this paper, various conventional and higher-order group constant evaluations and flux computation methods are compared for a simplified R-Z model of the EBR-II system. Although conventional methods do provide adequate predictions of the flux in the core region, significant mispredictions are observed in the reflector and radial blanket regions. Calculational comparisons indicate that a fine energy group structure is required for accurate predictions of the eigenvalue and flux distribution; greater detail is needed in the iron resonance scattering treatment. Calculational comparisons also indicate that transport theory with detailed anisotropic scattering treatment is required.

  18. Improved methods for predicting peptide binding affinity to MHC class II molecules.

    Science.gov (United States)

    Jensen, Kamilla Kjaergaard; Andreatta, Massimo; Marcatili, Paolo; Buus, Søren; Greenbaum, Jason A; Yan, Zhen; Sette, Alessandro; Peters, Bjoern; Nielsen, Morten

    2018-01-06

    Major histocompatibility complex class II (MHC-II) molecules are expressed on the surface of professional antigen-presenting cells where they display peptides to T helper cells, which orchestrate the onset and outcome of many host immune responses. Understanding which peptides will be presented by the MHC-II molecule is therefore important for understanding the activation of T helper cells and can be used to identify T-cell epitopes. We here present updated versions of two MHC-II-peptide binding affinity prediction methods, NetMHCII and NetMHCIIpan. These were constructed using an extended data set of quantitative MHC-peptide binding affinity data obtained from the Immune Epitope Database covering HLA-DR, HLA-DQ, HLA-DP and H-2 mouse molecules. We show that training with this extended data set improved the performance for peptide binding predictions for both methods. Both methods are publicly available at www.cbs.dtu.dk/services/NetMHCII-2.3 and www.cbs.dtu.dk/services/NetMHCIIpan-3.2. © 2018 John Wiley & Sons Ltd.

  19. Cuando la pintura es poesía: versos y jeroglíficos con que la Universidad de Santiago lloró a Carlos II

    Directory of Open Access Journals (Sweden)

    Nieves Pena Sueiro

    2007-01-01

    Full Text Available La muerte de Carlos II abría un período de incertidumbre que supuso el fin del reinado de la casa de Austria en España. Por este motivo las ceremonias que conmemoraron su muerte se llenaron de símbolos referentes a las dos dinastías. Presentamos la edición y estudio de un texto, único testimonio, que refleja cómo la Universidad de Santiago lloró a Carlos II a la vez que daba la bienvenida a Felipe V. The death of Carlos II supposed the aim of the reign of the house of Austria in Spain. For this reason the ceremonies that commemorated their death filled of referring symbols to the two dynasties. We present the edition and study of a text, only testimony, that reflects how the University of Santiago wept to Carlos II simultaneously that was giving the welcome to Philip V.

  20. Prediction of CMEs and Type II Bursts from Sun to Earth

    Science.gov (United States)

    Cairns, I. H.; Schmidt, J. M.; Gopalswamy, N.; van der Holst, B.

    2017-12-01

    Most major space weather events are due to fast CMEs and their shocks interacting with Earth's magnetosphere. SImilarly, type II solar radio bursts are well-known signatures of CMEs and their shocks moving through the corona and solar wind. The properties of the space weather events and the type II radio bursts depend sensitively on the CME velocity, shape, and evolution as functions of position and time, as well as on the magnetic field vector in the coronal and solar wind plasma, downstream of the CME shock, and inside the CME. We report simulations of CMEs and type II bursts from the Sun to Earth with the Space Weather Modelling Framework (2015 and 2016 versions), set up carefully using relevant data, and a kinetic radio emission theory. Excellent agreement between observations, simulations, and theory are found for the coronal (metric) type II burst of 7 September 2014 and associated CME, including the lack of radio emission in the solar wind beyond about 10 solar radii. Similarly, simulation of a CME and type II burst from the Sun to 1 AU over the period 29 November - 1 December 2013 yield excellent agreement for the radio burst from 10 MHz to 30 kHz for STEREO A and B and Wind, arrival of the CME at STEREO A within 1 hour reported time, deceleration of the CME in agreement with the Gopalswamy et al. [2011] observational analyses, and Bz rotations at STEREO A from upstream of the CME shock to within the CME. These results provide strong support for the type II theory and also that the Space WeatherModeling Framework can accurately predict the properties and evolution of CMEs and the interplanetary magnetic field and plasma from the Sun to 1 AU when sufficiently carefully initialized.

  1. Thrombocytosis portends adverse prognostic significance in patients with stage II colorectal carcinoma [v2; ref status: indexed, http://f1000r.es/4k6

    Directory of Open Access Journals (Sweden)

    Tianhua Guo

    2014-10-01

    Full Text Available Thrombocytosis portends adverse prognostic significance in many types of cancers including ovarian and lung carcinoma. In this study, we determined the prevalence and prognostic significance of thrombocytosis (defined as platelet count in excess of 400 × 103/μl in patients with colorectal cancer. We performed a retrospective analysis of 310 consecutive patients diagnosed at our Institution between 2004 and 2013. The patients (48.7% male and 51.3% female had a mean age of 69.9 years (+/- 12.7 years at diagnosis. Thrombocytosis was found in a total of 25 patients, with a higher incidence in those with stage III and IV disease (14.4% of patients. Although the mean platelet count increased with the depth of tumor invasion (pT, its values remained within normal limits in the whole patient cohort. No patient with stage I cancer (n=57 had elevated platelet count at diagnosis. By contrast, five of the 78 patients (6.4% with stage II cancer showed thrombocytosis, and four of these patients showed early recurrence and/or metastatic disease, resulting in shortened survival (they died within one year after surgery. The incidence of thrombocytosis increased to 12.2% and 20.6%, respectively, in patients with stage III and IV disease. The overall survival rate of patients with thrombocytosis was lower than those without thrombocytosis in the stage II and III disease groups, but this difference disappeared in patients with stage IV cancer who did poorly regardless of their platelet count. We concluded that thrombocytosis at diagnosis indicates adverse clinical outcome in colorectal cancer patients with stage II or III disease. This observation is especially intriguing in stage II patients because the clinical management of these patients is controversial. If our data are confirmed in larger studies, stage II colon cancer patients with thrombocytosis may be considered for adjuvant chemotherapy.

  2. Qualidade espermática do sêmen criopreservado de cães: II - Efeito do protocolo de resfriamento

    Directory of Open Access Journals (Sweden)

    Bueno R.

    2001-01-01

    Full Text Available Estudou-se o efeito de dois protocolos de resfriamento do sêmen de cães sobre a qualidade espermática in vitro, após sua criopreservação. Utilizaram-se três machos e realizaram-se cinco coletas em cada um deles. Os procedimentos de resfriamento foram realizados em um congelador de células (biocool e em caixa de isopor. Foram avaliadas a motilidade, o vigor espermático, a integridade da membrana plasmática (teste hiposmótico, a integridade do acrossoma e a longevidade espermática (teste de termo-resistência. A comparação entre os protocolos de resfriamento mostrou que não houve diferença (P>0,05 entre a caixa de isopor e o biocool logo após o resfriamento. Após a descongelação os resultados foram semelhantes entre os protocolos, observando-se diferença (P<0,05 apenas na motilidade espermática e no teste de termo-resistência (TTR, os quais foram superiores na caixa de isopor.

  3. Comparison of mortality prediction models and validation of SAPS II in critically ill burns patients.

    Science.gov (United States)

    Pantet, O; Faouzi, M; Brusselaers, N; Vernay, A; Berger, M M

    2016-06-30

    Specific burn outcome prediction scores such as the Abbreviated Burn Severity Index (ABSI), Ryan, Belgian Outcome of Burn Injury (BOBI) and revised Baux scores have been extensively studied. Validation studies of the critical care score SAPS II (Simplified Acute Physiology Score) have included burns patients but not addressed them as a cohort. The study aimed at comparing their performance in a Swiss burns intensive care unit (ICU) and to observe whether they were affected by a standardized definition of inhalation injury. We conducted a retrospective cohort study, including all consecutive ICU burn admissions (n=492) between 1996 and 2013: 5 epochs were defined by protocol changes. As required for SAPS II calculation, stays burned (TBSA) and inhalation injury (systematic standardized diagnosis since 2006). Study epochs were compared (χ2 test, ANOVA). Score performance was assessed by receiver operating characteristic curve analysis. SAPS II performed well (AUC 0.89), particularly in burns burns <40% TBSA. Ryan and BOBI scores were least accurate, as they heavily weight inhalation injury.

  4. HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses.

    Directory of Open Access Journals (Sweden)

    Nathan Erdmann

    2015-08-01

    Full Text Available Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1 exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences and HLA-II allelic data, we identified 29 HLA-II associated HIV sequence polymorphisms or adaptations (HLA-AP in an African cohort of chronically HIV-infected individuals. Epitopes encompassing the predicted adaptation (AE or its non-adapted (NAE version were evaluated for immunogenicity. Using a CD8-depleted IFN-γ ELISpot assay, we determined that the magnitude of CD4+ T cell responses to the predicted epitopes in controllers was higher compared to non-controllers (p<0.0001. However, regardless of the group, the magnitude of responses to AE was lower as compared to NAE (p<0.0001. CD4+ T cell responses in patients with acute HIV infection (AHI demonstrated poor immunogenicity towards AE as compared to NAE encoded by their transmitted founder virus. Longitudinal data in AHI off antiretroviral therapy demonstrated sequence changes that were biologically confirmed to represent CD4+ escape mutations. These data demonstrate an innovative application of HLA-associated polymorphisms to identify biologically relevant CD4+ epitopes and suggests CD4+ T cells are active participants in driving HIV evolution.

  5. Predictive validity of the Hendrich fall risk model II in an acute geriatric unit.

    Science.gov (United States)

    Ivziku, Dhurata; Matarese, Maria; Pedone, Claudio

    2011-04-01

    Falls are the most common adverse events reported in acute care hospitals, and older patients are the most likely to fall. The risk of falling cannot be completely eliminated, but it can be reduced through the implementation of a fall prevention program. A major evidence-based intervention to prevent falls has been the use of fall-risk assessment tools. Many tools have been increasingly developed in recent years, but most instruments have not been investigated regarding reliability, validity and clinical usefulness. This study intends to evaluate the predictive validity and inter-rater reliability of Hendrich fall risk model II (HFRM II) in order to identify older patients at risk of falling in geriatric units and recommend its use in clinical practice. A prospective descriptive design was used. The study was carried out in a geriatric acute care unit of an Italian University hospital. All over 65 years old patients consecutively admitted to a geriatric acute care unit of an Italian University hospital over 8-month period were enrolled. The patients enrolled were screened for the falls risk by nurses with the HFRM II within 24h of admission. The falls occurring during the patient's hospital stay were registered. Inter-rater reliability, area under the ROC curve, sensitivity, specificity, positive and negative predictive values and time for the administration were evaluated. 179 elderly patients were included. The inter-rater reliability was 0.87 (95% CI 0.71-1.00). The administration time was about 1min. The most frequently reported risk factors were depression, incontinence, vertigo. Sensitivity and specificity were respectively 86% and 43%. The optimal cut-off score for screening at risk patients was 5 with an area under the ROC curve of 0.72. The risk factors more strongly associated with falls were confusion and depression. As falls of older patients are a common problem in acute care settings it is necessary that the nurses use specific validate and reliable

  6. FutureTox II: in vitro data and in silico models for predictive toxicology.

    Science.gov (United States)

    Knudsen, Thomas B; Keller, Douglas A; Sander, Miriam; Carney, Edward W; Doerrer, Nancy G; Eaton, David L; Fitzpatrick, Suzanne Compton; Hastings, Kenneth L; Mendrick, Donna L; Tice, Raymond R; Watkins, Paul B; Whelan, Maurice

    2015-02-01

    FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  7. Prediction of the oscillator strengths for the electric dipole transitions in Th II

    Energy Technology Data Exchange (ETDEWEB)

    Dembczynski, Jerzy [Institute of Control and Information Engineering, Faculty of Electrical Engineering, Poznan University of Technology, Piotrowo 3A, 60-965 Poznan (Poland); Ruczkowski, Jaroslaw; Elantkowska, Magdalena [Laboratory of Quantum Engineering and Metrology, Faculty of Technical Physics, Poznan University of Technology, Nieszawska 13B, 60-965 Poznan (Poland)

    2014-07-01

    In order to parametrize the oscillator strength, the matrix of angular coefficients of the possible transitions in multiconfiguration system were calculated. In the odd and even configuration systems, the fine structure eigenvectors for both parities were obtained, using our semiempirical method, which taken into account also the second order effects, resulting from the excitations from electronic closed shells to open shells and from open shells to empty shell. The correctness of the fine structure wave functions was verified by the comparison of calculated and experimental hyperfine structure constants for Th II available in the literature. The least square fit to experimental values for some transitions allow to obtain the values of radial parameters and predict the oscillator strengths values for all possible transitions from the levels under consideration. These calculations are necessary for the design of the nuclear frequency standard based on the thorium ion.

  8. Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lundegaard, Claus; Lund, Ole

    2007-01-01

    the correct alignment of a peptide in the binding groove a crucial part of identifying the core of an MHC class II binding motif. Here, we present a novel stabilization matrix alignment method, SMM-align, that allows for direct prediction of peptide:MHC binding affinities. The predictive performance...... of the method is validated on a large MHC class II benchmark data set covering 14 HLA-DR (human MHC) and three mouse H2-IA alleles. RESULTS: The predictive performance of the SMM-align method was demonstrated to be superior to that of the Gibbs sampler, TEPITOPE, SVRMHC, and MHCpred methods. Cross validation...... between peptide data set obtained from different sources demonstrated that direct incorporation of peptide length potentially results in over-fitting of the binding prediction method. Focusing on amino terminal peptide flanking residues (PFR), we demonstrate a consistent gain in predictive performance...

  9. Accuracy and Predictability of PANC-3 Scoring System over APACHE II in Acute Pancreatitis: A Prospective Study.

    Science.gov (United States)

    Rathnakar, Surag Kajoor; Vishnu, Vikram Hubbanageri; Muniyappa, Shridhar; Prasath, Arun

    2017-02-01

    Acute Pancreatitis (AP) is one of the common conditions encountered in the emergency room. The course of the disease ranges from mild form to severe acute form. Most of these episodes are mild and spontaneously subsiding within 3 to 5 days. In contrast, Severe Acute Pancreatitis (SAP) occurring in around 15-20% of all cases, mortality can range between 10 to 85% across various centres and countries. In such a situation we need an indicator which can predict the outcome of an attack, as severe or mild, as early as possible and such an indicator should be sensitive and specific enough to trust upon. PANC-3 scoring is such a scoring system in predicting the outcome of an attack of AP. To assess the accuracy and predictability of PANC-3 scoring system over APACHE II in predicting severity in an attack of AP. This prospective study was conducted on 82 patients admitted with the diagnosis of pancreatitis. Investigations to evaluate PANC-3 and APACHE II were done on all the patients and the PANC-3 and APACHE II score was calculated. PANC-3 score has a sensitivity of 82.6% and specificity of 77.9%, the test had a Positive Predictive Value (PPV) of 0.59 and Negative Predictive Value (NPV) of 0.92. Sensitivity of APACHE II in predicting SAP was 91.3% and specificity was 96.6% with PPV of 0.91, NPV was 0.96. Our study shows that PANC-3 can be used to predict the severity of pancreatitis as efficiently as APACHE II. The interpretation of PANC-3 does not need expertise and can be applied at the time of admission which is an advantage when compared to classical scoring systems.

  10. The Value of the SYNTAX Score II in Predicting Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation.

    Science.gov (United States)

    Ryan, Nicola; Nombela-Franco, Luis; Jiménez-Quevedo, Pilar; Biagioni, Corina; Salinas, Pablo; Aldazábal, Andrés; Cerrato, Enrico; Gonzalo, Nieves; Del Trigo, María; Núñez-Gil, Iván; Fernández-Ortiz, Antonio; Macaya, Carlos; Escaned, Javier

    2017-11-27

    The predictive value of the SYNTAX score (SS) for clinical outcomes after transcatheter aortic valve implantation (TAVI) is very limited and could potentially be improved by the combination of anatomic and clinical variables, the SS-II. We aimed to evaluate the value of the SS-II in predicting outcomes in patients undergoing TAVI. A total of 402 patients with severe symptomatic aortic stenosis undergoing transfemoral TAVI were included. Preprocedural TAVI angiograms were reviewed and the SS-I and SS-II were calculated using the SS algorithms. Patients were stratified in 3 groups according to SS-II tertiles. The coprimary endpoints were all-cause death and major adverse cardiovascular events (MACE), a composite of all-cause death, cerebrovascular event, or myocardial infarction at 1 year. Increased SS-II was associated with higher 30-day mortality (P=.036) and major bleeding (P=.015). The 1-year risk of death and MACE was higher among patients in the 3rd SS-II tertile (HR, 2.60; P=.002 and HR, 2.66; P<.001) and was similar among patients in the 2nd tertile (HR, 1.27; P=.507 and HR, 1.05; P=.895) compared with patients in the 1st tertile. The highest SS-II tertile was an independent predictor of long-term mortality (P=.046) and MACE (P=.001). The SS-II seems more suited to predict clinical outcomes in patients undergoing TAVI than the SS-I. Increased SS-II was associated with poorer clinical outcomes at 1 and 4 years post-TAVI, independently of the presence of coronary artery disease. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  11. Prediction of individual mandibular changes induced by functional jaw orthopedics followed by fixed appliances in Class II patients.

    Science.gov (United States)

    Franchi, Lorenzo; Baccetti, Tiziano

    2006-11-01

    To identify pretreatment cephalometric variables for the prediction of individual mandibular outcomes of functional jaw orthopedics (FJO) followed by fixed appliances in Class II patients treated at the peak in mandibular growth. The study was performed on 51 subjects (24 females, 27 males) with Class II malocclusion. First-phase therapy was accomplished with a twin block in 16 subjects, a stainless steel crown Herbst in 15 subjects, and an acrylic splint Herbst in 20 subjects. Lateral cephalograms were available at the start of treatment with FJO and at the completion of fixed appliance therapy. All subjects received FJO at the peak in mandibular growth (CS 3 at T1). Individual responsiveness to Class II treatment including FJO was defined on the basis of the T2-T1 increment in total mandibular length (Co-Gn) when compared with untreated Class II subjects. Discriminant analysis identified a single predictive parameter (Co-Go-Me degrees) with a classification power of 80%. Pretreatment vertical and sagittal parameters were not able to improve the prediction based upon the mandibular angle. A Class II patient at the peak in skeletal maturation (CS 3) with a pretreatment Co-Go-Me degrees smaller than 125.5 degrees is expected to respond favorably to treatment including FJO. A Class II patient at CS 3 with a pretreatment value for Co-Go-Me degrees greater than 125.5 degrees is expected to respond poorly to treatment including FJO.

  12. The prediction of creep damage in Type 347 weld metal: part II creep fatigue tests

    International Nuclear Information System (INIS)

    Spindler, M.W.

    2005-01-01

    Calculations of creep damage under conditions of strain control are often carried out using either a time fraction approach or a ductility exhaustion approach. In part I of this paper the rupture strength and creep ductility data for a Type 347 weld metal were fitted to provide the material properties that are used to calculate creep damage. Part II of this paper examines whether the time fraction approach or the ductility exhaustion approach gives the better predictions of creep damage in creep-fatigue tests on the same Type 347 weld metal. In addition, a new creep damage model, which was developed by removing some of the simplifying assumptions that are made in the ductility exhaustion approach, was used. This new creep damage model is a function of the strain rate, stress and temperature and was derived from creep and constant strain rate test data using a reverse modelling technique (see part I of this paper). It is shown that the new creep damage model gives better predictions of creep damage in the creep-fatigue tests than the time fraction and the ductility exhaustion approaches

  13. Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method.

    Science.gov (United States)

    Nielsen, Morten; Lundegaard, Claus; Lund, Ole

    2007-07-04

    Antigen presenting cells (APCs) sample the extra cellular space and present peptides from here to T helper cells, which can be activated if the peptides are of foreign origin. The peptides are presented on the surface of the cells in complex with major histocompatibility class II (MHC II) molecules. Identification of peptides that bind MHC II molecules is thus a key step in rational vaccine design and developing methods for accurate prediction of the peptide:MHC interactions play a central role in epitope discovery. The MHC class II binding groove is open at both ends making the correct alignment of a peptide in the binding groove a crucial part of identifying the core of an MHC class II binding motif. Here, we present a novel stabilization matrix alignment method, SMM-align, that allows for direct prediction of peptide:MHC binding affinities. The predictive performance of the method is validated on a large MHC class II benchmark data set covering 14 HLA-DR (human MHC) and three mouse H2-IA alleles. The predictive performance of the SMM-align method was demonstrated to be superior to that of the Gibbs sampler, TEPITOPE, SVRMHC, and MHCpred methods. Cross validation between peptide data set obtained from different sources demonstrated that direct incorporation of peptide length potentially results in over-fitting of the binding prediction method. Focusing on amino terminal peptide flanking residues (PFR), we demonstrate a consistent gain in predictive performance by favoring binding registers with a minimum PFR length of two amino acids. Visualizing the binding motif as obtained by the SMM-align and TEPITOPE methods highlights a series of fundamental discrepancies between the two predicted motifs. For the DRB1*1302 allele for instance, the TEPITOPE method favors basic amino acids at most anchor positions, whereas the SMM-align method identifies a preference for hydrophobic or neutral amino acids at the anchors. The SMM-align method was shown to outperform other

  14. Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

    Directory of Open Access Journals (Sweden)

    Lund Ole

    2007-07-01

    Full Text Available Abstract Background Antigen presenting cells (APCs sample the extra cellular space and present peptides from here to T helper cells, which can be activated if the peptides are of foreign origin. The peptides are presented on the surface of the cells in complex with major histocompatibility class II (MHC II molecules. Identification of peptides that bind MHC II molecules is thus a key step in rational vaccine design and developing methods for accurate prediction of the peptide:MHC interactions play a central role in epitope discovery. The MHC class II binding groove is open at both ends making the correct alignment of a peptide in the binding groove a crucial part of identifying the core of an MHC class II binding motif. Here, we present a novel stabilization matrix alignment method, SMM-align, that allows for direct prediction of peptide:MHC binding affinities. The predictive performance of the method is validated on a large MHC class II benchmark data set covering 14 HLA-DR (human MHC and three mouse H2-IA alleles. Results The predictive performance of the SMM-align method was demonstrated to be superior to that of the Gibbs sampler, TEPITOPE, SVRMHC, and MHCpred methods. Cross validation between peptide data set obtained from different sources demonstrated that direct incorporation of peptide length potentially results in over-fitting of the binding prediction method. Focusing on amino terminal peptide flanking residues (PFR, we demonstrate a consistent gain in predictive performance by favoring binding registers with a minimum PFR length of two amino acids. Visualizing the binding motif as obtained by the SMM-align and TEPITOPE methods highlights a series of fundamental discrepancies between the two predicted motifs. For the DRB1*1302 allele for instance, the TEPITOPE method favors basic amino acids at most anchor positions, whereas the SMM-align method identifies a preference for hydrophobic or neutral amino acids at the anchors. Conclusion

  15. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction

    Directory of Open Access Journals (Sweden)

    Lund Ole

    2009-09-01

    Full Text Available Abstract Background The major histocompatibility complex (MHC molecule plays a central role in controlling the adaptive immune response to infections. MHC class I molecules present peptides derived from intracellular proteins to cytotoxic T cells, whereas MHC class II molecules stimulate cellular and humoral immunity through presentation of extracellularly derived peptides to helper T cells. Identification of which peptides will bind a given MHC molecule is thus of great importance for the understanding of host-pathogen interactions, and large efforts have been placed in developing algorithms capable of predicting this binding event. Results Here, we present a novel artificial neural network-based method, NN-align that allows for simultaneous identification of the MHC class II binding core and binding affinity. NN-align is trained using a novel training algorithm that allows for correction of bias in the training data due to redundant binding core representation. Incorporation of information about the residues flanking the peptide-binding core is shown to significantly improve the prediction accuracy. The method is evaluated on a large-scale benchmark consisting of six independent data sets covering 14 human MHC class II alleles, and is demonstrated to outperform other state-of-the-art MHC class II prediction methods. Conclusion The NN-align method is competitive with the state-of-the-art MHC class II peptide binding prediction algorithms. The method is publicly available at http://www.cbs.dtu.dk/services/NetMHCII-2.0.

  16. Prediction of Beck Depression Inventory (BDI-II) Score Using Acoustic Measurements in a Sample of Iium Engineering Students

    Science.gov (United States)

    Fikri Zanil, Muhamad; Nur Wahidah Nik Hashim, Nik; Azam, Huda

    2017-11-01

    Psychiatrist currently relies on questionnaires and interviews for psychological assessment. These conservative methods often miss true positives and might lead to death, especially in cases where a patient might be experiencing suicidal predisposition but was only diagnosed as major depressive disorder (MDD). With modern technology, an assessment tool might aid psychiatrist with a more accurate diagnosis and thus hope to reduce casualty. This project will explore on the relationship between speech features of spoken audio signal (reading) in Bahasa Malaysia with the Beck Depression Inventory scores. The speech features used in this project were Power Spectral Density (PSD), Mel-frequency Ceptral Coefficients (MFCC), Transition Parameter, formant and pitch. According to analysis, the optimum combination of speech features to predict BDI-II scores include PSD, MFCC and Transition Parameters. The linear regression approach with sequential forward/backward method was used to predict the BDI-II scores using reading speech. The result showed 0.4096 mean absolute error (MAE) for female reading speech. For male, the BDI-II scores successfully predicted 100% less than 1 scores difference with MAE of 0.098437. A prediction system called Depression Severity Evaluator (DSE) was developed. The DSE managed to predict one out of five subjects. Although the prediction rate was low, the system precisely predict the score within the maximum difference of 4.93 for each person. This demonstrates that the scores are not random numbers.

  17. Pol II promoter prediction using characteristic 4-mer motifs: a machine learning approach

    Directory of Open Access Journals (Sweden)

    Shoyaib Mohammad

    2008-10-01

    Full Text Available Abstract Background Eukaryotic promoter prediction using computational analysis techniques is one of the most difficult jobs in computational genomics that is essential for constructing and understanding genetic regulatory networks. The increased availability of sequence data for various eukaryotic organisms in recent years has necessitated for better tools and techniques for the prediction and analysis of promoters in eukaryotic sequences. Many promoter prediction methods and tools have been developed to date but they have yet to provide acceptable predictive performance. One obvious criteria to improve on current methods is to devise a better system for selecting appropriate features of promoters that distinguish them from non-promoters. Secondly improved performance can be achieved by enhancing the predictive ability of the machine learning algorithms used. Results In this paper, a novel approach is presented in which 128 4-mer motifs in conjunction with a non-linear machine-learning algorithm utilising a Support Vector Machine (SVM are used to distinguish between promoter and non-promoter DNA sequences. By applying this approach to plant, Drosophila, human, mouse and rat sequences, the classification model has showed 7-fold cross-validation percentage accuracies of 83.81%, 94.82%, 91.25%, 90.77% and 82.35% respectively. The high sensitivity and specificity value of 0.86 and 0.90 for plant; 0.96 and 0.92 for Drosophila; 0.88 and 0.92 for human; 0.78 and 0.84 for mouse and 0.82 and 0.80 for rat demonstrate that this technique is less prone to false positive results and exhibits better performance than many other tools. Moreover, this model successfully identifies location of promoter using TATA weight matrix. Conclusion The high sensitivity and specificity indicate that 4-mer frequencies in conjunction with supervised machine-learning methods can be beneficial in the identification of RNA pol II promoters comparative to other methods. This

  18. PHENOstruct: Prediction of human phenotype ontology terms using heterogeneous data sources [v1; ref status: indexed, http://f1000r.es/5j2

    Directory of Open Access Journals (Sweden)

    Indika Kahanda

    2015-07-01

    Full Text Available The human phenotype ontology (HPO was recently developed as a standardized vocabulary for describing the phenotype abnormalities associated with human diseases. At present, only a small fraction of human protein coding genes have HPO annotations. But, researchers believe that a large portion of currently unannotated genes are related to disease phenotypes. Therefore, it is important to predict gene-HPO term associations using accurate computational methods. In this work we demonstrate the performance advantage of the structured SVM approach which was shown to be highly effective for Gene Ontology term prediction in comparison to several baseline methods. Furthermore, we highlight a collection of informative data sources suitable for the problem of predicting gene-HPO associations, including large scale literature mining data.

  19. Bayesian prediction of microbial oxygen requirement [v1; ref status: indexed, http://f1000r.es/1m6

    Directory of Open Access Journals (Sweden)

    Dan B. Jensen

    2013-09-01

    Full Text Available Background: Prediction of the optimal habitat conditions for a given bacterium, based on genome sequence alone would be of value for scientific as well as industrial purposes. One example of such a habitat adaptation is the requirement for oxygen. In spite of good genome data availability, there have been only a few prediction attempts of bacterial oxygen requirements, using genome sequences. Here, we describe a method for distinguishing aerobic, anaerobic and facultative anaerobic bacteria, based on genome sequence-derived input, using naive Bayesian inference. In contrast, other studies found in literature only demonstrate the ability to distinguish two classes at a time. Results: The results shown in the present study are as good as or better than comparable methods previously described in the scientific literature, with an arguably simpler method, when results are directly compared. This method further compares the performance of a single-step naive Bayesian prediction of the three included classifications, compared to a simple Bayesian network with two steps. A two-step network, distinguishing first respiring from non-respiring organisms, followed by the distinction of aerobe and facultative anaerobe organisms within the respiring group, is found to perform best. Conclusions: A simple naive Bayesian network based on the presence or absence of specific protein domains within a genome is an effective and easy way to predict bacterial habitat preferences, such as oxygen requirement.

  20. Progress and challenges in the computational prediction of gene function using networks [v1; ref status: indexed, http://f1000r.es/SqmJUM

    Directory of Open Access Journals (Sweden)

    Paul Pavlidis

    2012-09-01

    Full Text Available In this opinion piece, we attempt to unify recent arguments we have made that serious confounds affect the use of network data to predict and characterize gene function. The development of computational approaches to determine gene function is a major strand of computational genomics research. However, progress beyond using BLAST to transfer annotations has been surprisingly slow. We have previously argued that a large part of the reported success in using "guilt by association" in network data is due to the tendency of methods to simply assign new functions to already well-annotated genes. While such predictions will tend to be correct, they are generic; it is true, but not very helpful, that a gene with many functions is more likely to have any function. We have also presented evidence that much of the remaining performance in cross-validation cannot be usefully generalized to new predictions, making progressive improvement in analysis difficult to engineer. Here we summarize our findings about how these problems will affect network analysis, discuss some ongoing responses within the field to these issues, and consolidate some recommendations and speculation, which we hope will modestly increase the reliability and specificity of gene function prediction.

  1. Persistent type II endoleak after EVAR: the predictive value of the AAA thrombus volume.

    Science.gov (United States)

    Gallitto, Enrico; Gargiulo, Mauro; Mascoli, Chiara; Freyrie, Antonio; DE Matteis, Massimo; Serra, Carla; Bianchini Massoni, Claudio; Faggioli, Gianluca; Stella, Andrea

    2018-02-01

    Persistent type II endoleaks (ELIIp, ≥6 months) after an endovascular aneurysm repair (EVAR) can be associated with adverse outcomes. The aims of this study are the evaluation of the incidence of ELIIp, their preoperative morphological predictive features (PMF) and the post-EVAR abdominal aortic aneurysm (AAA) evolution in the presence of ELIIp. Patients underwent EVAR between 2008 and 2010 were prospectively collected. Cases with ELIIp (group A: AG) were identified. A control group without ELIIp (group B: BG), homogeneous for clinical characteristics, follow-up timing and methods (CTA and/or CEUS at 6.12 months and yearly thereafter) was retrospectively selected. The PMF evaluated by computed-tomography-angiography (CTA) were: AAA-diameter, number and diameter of AAA efferent patent vessels (EPV), AAA-total volume (TV), AAA-thrombus volume (THV) and TV/THV rate (%VR). Volumes were calculated by the dedicated vessels analysis software. AG and BG were compared. The primary endpoint was to evaluate the incidence of ELIIp. Secondary endpoints were to analyze the relation between PMF and ELIIp and to assess the post-EVAR AAA-evolution in the presence of ELIIp. Between 2008 and 2010, 200 patients underwent EVAR to treat AAA electively. An ELIIp was detected in 35cases (17.5%) (AG). Twenty-seven patients (13.5%) were included in BG. An overall of 62 patients (GA+GB) were analyzed. The mean pre-operative AAA diameter and EPV were 58±11.6 mm and 5.5±1.8 mm, respectively. The mean TV and THV were 187±111.5 cc and 82±75 cc, respectively. The median %VR was 42.3%. ELIIp was correlated to EPV≥6 (χ2, p=.015) and %VR AAA growth post-EVAR. ELIIp is a not rare complication and it could require re-interventions. Our data suggest that VEP≥6 or %VT<40% are risk factors for ELIIp. No PMF was able to predict the ELIIp evolution. The relative high rate of re-interventions, could suggest the need of adjunctive/preventing primary procedures in patients at high-risk for ELIIp.

  2. Predicting critical temperatures of iron(II) spin crossover materials: Density functional theory plus U approach

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yachao, E-mail: yczhang@nano.gznc.edu.cn [Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang 550018, Guizhou (China)

    2014-12-07

    A first-principles study of critical temperatures (T{sub c}) of spin crossover (SCO) materials requires accurate description of the strongly correlated 3d electrons as well as much computational effort. This task is still a challenge for the widely used local density or generalized gradient approximations (LDA/GGA) and hybrid functionals. One remedy, termed density functional theory plus U (DFT+U) approach, introduces a Hubbard U term to deal with the localized electrons at marginal computational cost, while treats the delocalized electrons with LDA/GGA. Here, we employ the DFT+U approach to investigate the T{sub c} of a pair of iron(II) SCO molecular crystals (α and β phase), where identical constituent molecules are packed in different ways. We first calculate the adiabatic high spin-low spin energy splitting ΔE{sub HL} and molecular vibrational frequencies in both spin states, then obtain the temperature dependent enthalpy and entropy changes (ΔH and ΔS), and finally extract T{sub c} by exploiting the ΔH/T − T and ΔS − T relationships. The results are in agreement with experiment. Analysis of geometries and electronic structures shows that the local ligand field in the α phase is slightly weakened by the H-bondings involving the ligand atoms and the specific crystal packing style. We find that this effect is largely responsible for the difference in T{sub c} of the two phases. This study shows the applicability of the DFT+U approach for predicting T{sub c} of SCO materials, and provides a clear insight into the subtle influence of the crystal packing effects on SCO behavior.

  3. [Role of angiotensin II receptor type 2 in predicting biochemical recurrence in the treatment of prostate cancer].

    Science.gov (United States)

    Chibichyan, M B; Kogan, M I; Chernogubova, E A; Pavlenko, I A; Matishov, D G

    2016-12-01

    To identify markers for predicting aggressive forms of prostate cancer. The study retrospectively evaluated expression of angiotensin II type 2 receptors (AT2-R) in prostate needle biopsy tissue from patients with and without biochemical recurrence after combined hormone and radiation therapy. The study findings showed that low expression of AT2-R in prostate tissue was associated with a high risk of biochemical recurrence. The data on the nature of AT2-R expression in prostate tissue of prostate cancer patients may be considered as a tool for predicting biochemical recurrence after combined hormone and radiation therapy. The test has a sensitivity of 87.5% and specificity of 85.71%.

  4. Measurement and prediction of dabigatran etexilate mesylate Form II solubility in mono-solvents and mixed solvents

    International Nuclear Information System (INIS)

    Xiao, Yan; Wang, Jingkang; Wang, Ting; Ouyang, Jinbo; Huang, Xin; Hao, Hongxun; Bao, Ying; Fang, Wen; Yin, Qiuxiang

    2016-01-01

    Highlights: • Solubility of DEM Form II in mono-solvents and binary solvent mixtures was measured. • Regressed UNIFAC model was used to predict the solubility in solvent mixtures. • The experimental solubility data were correlated by different models. - Abstract: UV spectrometer method was used to measure the solubility data of dabigatran etexilate mesylate (DEM) Form II in five mono-solvents (methanol, ethanol, ethane-1,2-diol, DMF, DMAC) and binary solvent mixtures of methanol and ethanol in the temperature range from 287.37 K to 323.39 K. The experimental solubility data in mono-solvents were correlated with modified Apelblat equation, van’t Hoff equation and λh equation. GSM model and Modified Jouyban-Acree model were employed to correlate the solubility data in mixed solvent systems. And Regressed UNIFAC model was used to predict the solubility of DEM Form II in the binary solvent mixtures. Results showed that the predicted data were consistent with the experimental data.

  5. Improved methods for predicting peptide binding affinity to MHC class II molecules

    DEFF Research Database (Denmark)

    Jensen, Kamilla Kjærgaard; Andreatta, Massimo; Marcatili, Paolo

    2018-01-01

    Major histocompatibility complex class II (MHC-II) molecules are expressed on the surface of professional antigen presenting cells where they display peptides to T helper cells, which orchestrate the onset and outcome of many host immune responses. Understanding which peptides will be presented b...... are publicly available at www.cbs.dtu.dk/services/NetMHCII-2.3 and www.cbs.dtu.dk/services/NetMHCIIpan-3.2. This article is protected by copyright. All rights reserved....

  6. Validation of the LOD score compared with APACHE II score in prediction of the hospital outcome in critically ill patients.

    Science.gov (United States)

    Khwannimit, Bodin

    2008-01-01

    The Logistic Organ Dysfunction score (LOD) is an organ dysfunction score that can predict hospital mortality. The aim of this study was to validate the performance of the LOD score compared with the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in a mixed intensive care unit (ICU) at a tertiary referral university hospital in Thailand. The data were collected prospectively on consecutive ICU admissions over a 24 month period from July1, 2004 until June 30, 2006. Discrimination was evaluated by the area under the receiver operating characteristic curve (AUROC). The calibration was assessed by the Hosmer-Lemeshow goodness-of-fit H statistic. The overall fit of the model was evaluated by the Brier's score. Overall, 1,429 patients were enrolled during the study period. The mortality in the ICU was 20.9% and in the hospital was 27.9%. The median ICU and hospital lengths of stay were 3 and 18 days, respectively, for all patients. Both models showed excellent discrimination. The AUROC for the LOD and APACHE II were 0.860 [95% confidence interval (CI) = 0.838-0.882] and 0.898 (95% Cl = 0.879-0.917), respectively. The LOD score had perfect calibration with the Hosmer-Lemeshow goodness-of-fit H chi-2 = 10 (p = 0.44). However, the APACHE II had poor calibration with the Hosmer-Lemeshow goodness-of-fit H chi-2 = 75.69 (p < 0.001). Brier's score showed the overall fit for both models were 0.123 (95%Cl = 0.107-0.141) and 0.114 (0.098-0.132) for the LOD and APACHE II, respectively. Thus, the LOD score was found to be accurate for predicting hospital mortality for general critically ill patients in Thailand.

  7. Numerical Predictions of Wind Turbine Power and Aerodynamic Loads for the NREL Phase II and IV Combined Experiment Rotor

    Science.gov (United States)

    Duque, Earl P. N.; Johnson, Wayne; vanDam, C. P.; Chao, David D.; Cortes, Regina; Yee, Karen

    1999-01-01

    Accurate, reliable and robust numerical predictions of wind turbine rotor power remain a challenge to the wind energy industry. The literature reports various methods that compare predictions to experiments. The methods vary from Blade Element Momentum Theory (BEM), Vortex Lattice (VL), to variants of Reynolds-averaged Navier-Stokes (RaNS). The BEM and VL methods consistently show discrepancies in predicting rotor power at higher wind speeds mainly due to inadequacies with inboard stall and stall delay models. The RaNS methodologies show promise in predicting blade stall. However, inaccurate rotor vortex wake convection, boundary layer turbulence modeling and grid resolution has limited their accuracy. In addition, the inherently unsteady stalled flow conditions become computationally expensive for even the best endowed research labs. Although numerical power predictions have been compared to experiment. The availability of good wind turbine data sufficient for code validation experimental data that has been extracted from the IEA Annex XIV download site for the NREL Combined Experiment phase II and phase IV rotor. In addition, the comparisons will show data that has been further reduced into steady wind and zero yaw conditions suitable for comparisons to "steady wind" rotor power predictions. In summary, the paper will present and discuss the capabilities and limitations of the three numerical methods and make available a database of experimental data suitable to help other numerical methods practitioners validate their own work.

  8. Low Expression of TBX4 Predicts Poor Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Meijuan Zong

    2011-08-01

    Full Text Available This study was designed to investigate the expression of the T-box transcription factor 4 (TBX4, a tumor biomarker that was previously identified by proteomics, in pancreatic ductal adenocarcinoma (PDAC and evaluate its clinical utility as a potential prognostic biomarkers for PDAC. The expression of TBX4 was detected in 77 stage II PDAC tumors by immunohistochemistry, and the results were analyzed with regard to clinicopathological characteristics and overall survival. Moreover, Tbx4 promoter methylation status in primary PDAC tumors and normal adjacent pancreas tissues was measured by bisulfite sequencing. Among 77 stage II PDAC tumors, 48 cases (62.3% expressed TBX4 at a high level. No significant correlation between TBX4 expression and other clinicopathological parameters, except tumor grade and liver metastasis recurrence, was found. The survival of patients with TBX4-high expression was significantly longer than those with TBX4-low expression (P = 0.010. In multivariate analysis, low TBX4 expression was an independent prognostic factor for overall survival in patients with stage II PDAC. TBX4 promoter methylation status was frequently observed in both PDAC and normal adjacent pancreas. We conclude that a low level of TBX4 expression suggests a worse prognosis for patients with stage II PDAC. Down-regulation of the TBX4 gene in pancreas is less likely to be regulated by DNA methylation.

  9. Prediction of RNA Polymerase II recruitment, elongation and stalling from histone modification data

    DEFF Research Database (Denmark)

    Chen, Yun; Jørgensen, Mette; Kolde, Raivo

    2011-01-01

    of RNAPII stalling. CONCLUSIONS: In this study we introduce a general framework to accurately predict the level of RNAPII recruitment, elongation, stalling and mRNA expression from chromatin signals. The versatility of the method also makes it ideally suited to investigate other genomic data....... strategies are needed to progress from descriptive annotation of data to quantitative, predictive models. RESULTS: Here, we describe a computational framework which with high accuracy can predict the locations of core promoters, the amount of recruited RNAPII at the promoter, the amount of elongating RNAPII...... of these four marks are found to be necessary for recruitment of RNAPII but not sufficient for the elongation. We also show that the spatial distributions of histone marks are almost as predictive as the signal strength and that a set of histone marks immediately downstream of the TSS is highly predictive...

  10. Predictive Performance of the Simplified Acute Physiology Score (SAPS) II and the Initial Sequential Organ Failure Assessment (SOFA) Score in Acutely Ill Intensive Care Patients

    DEFF Research Database (Denmark)

    Granholm, Anders; Møller, Morten Hylander; Kragh, Mette

    2016-01-01

    PURPOSE: Severity scores including the Simplified Acute Physiology Score (SAPS) II and the Sequential Organ Failure Assessment (SOFA) score are used in intensive care units (ICUs) to assess disease severity, predict mortality and in research. We aimed to assess the predictive performance of SAPS II...... compared the discrimination of SAPS II and initial SOFA scores, compared the discrimination of SAPS II in our cohort with the original cohort, assessed the calibration of SAPS II customised to our cohort, and compared the discrimination for 90-day mortality vs. in-hospital mortality for both scores....... Discrimination was evaluated using areas under the receiver operating characteristics curves (AUROC). Calibration was evaluated using Hosmer-Lemeshow's goodness-of-fit Ĉ-statistic. RESULTS: AUROC for in-hospital mortality was 0.80 (95% confidence interval (CI) 0.77-0.83) for SAPS II and 0.73 (95% CI 0...

  11. Statistical downscaling of historical monthly mean winds over a coastal region of complex terrain. II. Predicting wind components

    Energy Technology Data Exchange (ETDEWEB)

    Kamp, Derek van der [University of Victoria, Pacific Climate Impacts Consortium, Victoria, BC (Canada); University of Victoria, School of Earth and Ocean Sciences, Victoria, BC (Canada); Curry, Charles L. [Environment Canada University of Victoria, Canadian Centre for Climate Modelling and Analysis, Victoria, BC (Canada); University of Victoria, School of Earth and Ocean Sciences, Victoria, BC (Canada); Monahan, Adam H. [University of Victoria, School of Earth and Ocean Sciences, Victoria, BC (Canada)

    2012-04-15

    A regression-based downscaling technique was applied to monthly mean surface wind observations from stations throughout western Canada as well as from buoys in the Northeast Pacific Ocean over the period 1979-2006. A predictor set was developed from principal component analysis of the three wind components at 500 hPa and mean sea-level pressure taken from the NCEP Reanalysis II. Building on the results of a companion paper, Curry et al. (Clim Dyn 2011), the downscaling was applied to both wind speed and wind components, in an effort to evaluate the utility of each type of predictand. Cross-validated prediction skill varied strongly with season, with autumn and summer displaying the highest and lowest skill, respectively. In most cases wind components were predicted with better skill than wind speeds. The predictive ability of wind components was found to be strongly related to their orientation. Wind components with the best predictions were often oriented along topographically significant features such as constricted valleys, mountain ranges or ocean channels. This influence of directionality on predictive ability is most prominent during autumn and winter at inland sites with complex topography. Stations in regions with relatively flat terrain (where topographic steering is minimal) exhibit inter-station consistencies including region-wide seasonal shifts in the direction of the best predicted wind component. The conclusion that wind components can be skillfully predicted only over a limited range of directions at most stations limits the scope of statistically downscaled wind speed predictions. It seems likely that such limitations apply to other regions of complex terrain as well. (orig.)

  12. Prediction of equilibrium parameters of adsorption of lead (II) ions onto diatomite

    Science.gov (United States)

    Salman, Taylan; Ardalı, Yüksel; Gamze Turan, N.

    2013-04-01

    Heavy metals from industrial wastewaters are one of the most important environmental issues to be solved today. Due to their toxicity and nonbiodegradable nature, heavy metals cause environmental and public health problems. Various techniques have been developed to remove heavy metals from aqueous solutions. These include chemical precipitation, reverse osmosis, ion Exchange and adsorption. Among them, adsorption is considered to be a particularly competitive and effective process for the removal of heavy metals from aqueous solutions. There is growing interest in using low cost, commercially available materials for the adsorption of heavy metals. Diatomite is a siliceous sedimentary rock having an amorphous form of silica (SiO2. nH2O) containing a small amount of microcrystalline material. It has unique combination of physical and chemical properties such as high porosity, high permeability, small particle size, large surface area, and low thermal conductivity. In addition, it is available in Turkey and in various locations around the world. Therefore, diatomite has been successfully used as adsorbent for the removal of heavy metals. The aim of the study is to investigate the adsorption properties of diatomite. The equilibrium adsorption data were applied to the Langmuir, Freundlich and Dubinin-Radushkevic (D-R) isotherm models. Adsorption experiments were performed under batch process, using Pb (II) initial concentration, pH of solution and contact time as variables. The results demonstrated that the adsorption of Pb (II) was strongly dependent on pH of solution. The effect of pH on adsorption of Pb(II) on diatomite was conducted by varying pH from 2 to 12 at 20 oC. In the pH range of 2.0-4.0, the adsorption percentage increases slightly as the pH increasing. At pH>4, the adsorption percentage decreases with increasing pH because hydrolysis product and the precipitation begin to play an important role in the sorption of Pb (II). At pH4, the maximum adsorption

  13. Cucurbitacées

    African Journals Online (AJOL)

    SARAH

    31 août 2015 ... Environ 58,17% des consommateurs des produits à base des graines de Cucurbitacées consomment régulièrement la sauce liquide simple de courge. Elle est obtenue par deux différentes méthodes selon les consommateurs. La première(A1) pratiquée par les 64,12% des consommateurs de cette sauce.

  14. High Order Wavelet-Based Multiresolution Technology for Airframe Noise Prediction, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a novel, high-accuracy, high-fidelity, multiresolution (MRES), wavelet-based framework for efficient prediction of airframe noise sources and...

  15. Fluid mechanics of dynamic stall. II - Prediction of full scale characteristics

    Science.gov (United States)

    Ericsson, L. E.; Reding, J. P.

    1988-01-01

    Analytical extrapolations are made from experimental subscale dynamics to predict full scale characteristics of dynamic stall. The method proceeds by establishing analytic relationships between dynamic and static aerodynamic characteristics induced by viscous flow effects. The method is then validated by predicting dynamic test results on the basis of corresponding static test data obtained at the same subscale flow conditions, and the effect of Reynolds number on the static aerodynamic characteristics are determined from subscale to full scale flow conditions.

  16. Predictive modeling of coupled multi-physics systems: II. Illustrative application to reactor physics

    International Nuclear Information System (INIS)

    Cacuci, Dan Gabriel; Badea, Madalina Corina

    2014-01-01

    Highlights: • We applied the PMCMPS methodology to a paradigm neutron diffusion model. • We underscore the main steps in applying PMCMPS to treat very large coupled systems. • PMCMPS reduces the uncertainties in the optimally predicted responses and model parameters. • PMCMPS is for sequentially treating coupled systems that cannot be treated simultaneously. - Abstract: This work presents paradigm applications to reactor physics of the innovative mathematical methodology for “predictive modeling of coupled multi-physics systems (PMCMPS)” developed by Cacuci (2014). This methodology enables the assimilation of experimental and computational information and computes optimally predicted responses and model parameters with reduced predicted uncertainties, taking fully into account the coupling terms between the multi-physics systems, but using only the computational resources that would be needed to perform predictive modeling on each system separately. The paradigm examples presented in this work are based on a simple neutron diffusion model, chosen so as to enable closed-form solutions with clear physical interpretations. These paradigm examples also illustrate the computational efficiency of the PMCMPS, which enables the assimilation of additional experimental information, with a minimal increase in computational resources, to reduce the uncertainties in predicted responses and best-estimate values for uncertain model parameters, thus illustrating how very large systems can be treated without loss of information in a sequential rather than simultaneous manner

  17. Prediction of a new region in the H-T phase diagram of a disordered type II superconductor

    International Nuclear Information System (INIS)

    Nandgaonkar, Ajay; Kanhere, D.G.; Trivedi, Nandini

    1997-01-01

    The phase diagram of a type II superconductor (SC) in the magnetic field (B) - temperature (T) plane is shown schematically. At low T the system consists of an Abrikosov triangular vortex lattice which melts as the temperature is increased. At high B, the rigidity of the vortex lattice C 66 decreases with increasing B. Thus, the melting curve essentially tracks the H c2 behaviour, as shown in region (a) in fig. It was further suggested by Nelson, based on a mapping of vortices in 3D onto a problem of boson world-lines in spatial 2D and 1 imaginary dimension, that the classical statistical mechanics of vortices is analogous to the problem of quantum melting of the bosons. He used this mapping to predict a novel reentrant behavior of the phase boundary. These predictions were verified by experiments

  18. Structure-based prediction and identification of 4-epimerization activity of phosphate sugars in class II aldolases.

    Science.gov (United States)

    Lee, Seon-Hwa; Hong, Seung-Hye; An, Jung-Ung; Kim, Kyoung-Rok; Kim, Dong-Eun; Kang, Lin-Woo; Oh, Deok-Kun

    2017-05-16

    Sugar 4-epimerization reactions are important for the production of rare sugars and their derivatives, which have various potential industrial applications. For example, the production of tagatose, a functional sweetener, from fructose by sugar 4-epimerization is currently constrained because a fructose 4-epimerase does not exist in nature. We found that class II D-fructose-1,6-bisphosphate aldolase (FbaA) catalyzed the 4-epimerization of D-fructose-6-phosphate (F6P) to D-tagatose-6-phosphate (T6P) based on the prediction via structural comparisons with epimerase and molecular docking and the identification of the condensed products of C3 sugars. In vivo, the 4-epimerization activity of FbaA is normally repressed. This can be explained by our results showing the catalytic efficiency of D-fructose-6-phosphate kinase for F6P phosphorylation was significantly higher than that of FbaA for F6P epimerization. Here, we identified the epimerization reactions and the responsible catalytic residues through observation of the reactions of FbaA and L-rhamnulose-1-phosphate aldolases (RhaD) variants with substituted catalytic residues using different substrates. Moreover, we obtained detailed potential epimerization reaction mechanism of FbaA and a general epimerization mechanism of the class II aldolases L-fuculose-1-phosphate aldolase, RhaD, and FbaA. Thus, class II aldolases can be used as 4-epimerases for the stereo-selective synthesis of valuable carbohydrates.

  19. A Study on the Tracking and Position Predictions of Artificial Satellite (II

    Directory of Open Access Journals (Sweden)

    Pil-Ho Park

    1991-06-01

    Full Text Available We developed a software system called IODS (ISSA Orbit Determination System, which can predict the orbit of arbitrary artificial satellite using the numerical method. For evaluating the orbit prediction accuracy of IODS, the orbital data predicted for the meteorological satellite NOAA-11 and the stationary satellite INTELSAT-V are intercompared with those tracked at the Central Bureau of Meteorology and the Kum-San Satellites Communication Station. And the Perturbation affecting the orbit of these artificial satellites are quantitatively analyzed. The orbital variation and the eclipse phenomina due to the earth shadow are analyzed for a hypothetical geostationary satellite called KORSAT-1 which is assumed to be located in longitude 110°E.

  20. Quantitative impact of aerosols on numerical weather prediction. Part II: Impacts to IR radiance assimilation

    Science.gov (United States)

    Marquis, J. W.; Campbell, J. R.; Oyola, M. I.; Ruston, B. C.; Zhang, J.

    2017-12-01

    This is part II of a two-part series examining the impacts of aerosol particles on weather forecasts. In this study, the aerosol indirect effects on weather forecasts are explored by examining the temperature and moisture analysis associated with assimilating dust contaminated hyperspectral infrared radiances. The dust induced temperature and moisture biases are quantified for different aerosol vertical distribution and loading scenarios. The overall impacts of dust contamination on temperature and moisture forecasts are quantified over the west coast of Africa, with the assistance of aerosol retrievals from AERONET, MPL, and CALIOP. At last, methods for improving hyperspectral infrared data assimilation in dust contaminated regions are proposed.

  1. COSIMA-ES-PORT

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn; Leleur, Steen

    2007-01-01

    This article describes the results of the research project – WP3 East-west, Interreg IIIB – concerning the de¬velop¬ment of a new composite decision model, COSIMA-ES-PORT, for the assessment of three pre-feasibility studies situated at the Port of Esbjerg: a road project, a railway project...... and a multimodal terminal. The three studies indicates that a new road connection to the Port of Esbjerg is a very profitable project due to large travel time savings, whereas a new railway connection is not economically viable. However, a new multimodal terminal is also a very profitable project. The COSIMA...

  2. Specific responsible environmental behavior among boaters on the Chesapeake Bay: a predictive model part II

    Science.gov (United States)

    Stuart P. Cottrell; Alan R. Graefe

    1995-01-01

    This paper examines predictors of boater behavior in a specific behavior situation, namely the percentage of raw sewage discharged from recreational vessels in a sanitation pumpout facility on the Chesapeake Bay. Results of a multiple regression analysis show knowledge predicts behavior in specific issue situations. In addition, the more specific the...

  3. Predicted Geology of the Pahute Mesa-Oasis Valley Phase II Drilling Initiative

    International Nuclear Information System (INIS)

    2009-01-01

    Pahute Mesa-Oasis Valley (PM-OV) Phase II drilling will occur within an area that encompasses approximately 117 square kilometers (45 square miles) near the center of the Phase I PM-OV hydrostratigraphic framework model area. The majority of the investigation area lies within dissected volcanic terrain between Pahute Mesa on the north and Timber Mountain on the south. This area consists of a complex distribution of volcanic tuff and lava of generally rhyolitic composition erupted from nearby calderas and related vents. Several large buried volcanic structural features control the distribution of volcanic units in the investigation area. The Area 20 caldera, including its structural margin and associated caldera collapse collar, underlies the northeastern portion of the investigation area. The southern half of the investigation area lies within the northwestern portion of the Timber Mountain caldera complex, including portions of the caldera moat and resurgent dome. Another significant structural feature in the area is the west-northwest-trending Northern Timber Mountain moat structural zone, which bisects the northern portion of the investigation area and forms a structural bench. The proposed wells of the UGTA Phase II drilling initiative can be grouped into four generalized volcanic structural domains based on the stratigraphic distribution and structural position of the volcanic rocks in the upper 1,000 meters (3,300 feet) of the crust, a depth that represents the approximate planned total depths of the proposed wells

  4. SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes

    Directory of Open Access Journals (Sweden)

    Atul Kumar

    2017-06-01

    Full Text Available Type II diabetes is a chronic condition that affects the way our body metabolizes sugar. The body's important source of fuel is now becoming a chronic disease all over the world. It is now very necessary to identify the new potential targets for the drugs which not only control the disease but also can treat it. Support vector machines are the classifier which has a potential to make a classification of the discriminatory genes and non-discriminatory genes. SVMRFE a modification of SVM ranks the genes based on their discriminatory power and eliminate the genes which are not involved in causing the disease. A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target.

  5. Feasibility and predictive performance of the Hendrich Fall Risk Model II in a rehabilitation department: a prospective study.

    Science.gov (United States)

    Campanini, Isabella; Mastrangelo, Stefano; Bargellini, Annalisa; Bassoli, Agnese; Bosi, Gabriele; Lombardi, Francesco; Tolomelli, Stefano; Lusuardi, Mirco; Merlo, Andrea

    2018-01-11

    Falls are a common adverse event in both elderly inpatients and patients admitted to rehabilitation units. The Hendrich Fall Risk Model II (HIIFRM) has been already tested in all hospital wards with high fall rates, with the exception of the rehabilitation setting. This study's aim is to address the feasibility and predictive performances of HIIFRM in a hospital rehabilitation department. A 6 months prospective study in a Italian rehabilitation department with patients from orthopaedic, pulmonary, and neurological rehabilitation wards. All admitted patients were enrolled and assessed within 24 h of admission by means of the HIIFRM. The occurrence of falls was checked and recorded daily. HIIFRM feasibility was assessed as the percentage of successful administrations at admission. HIIFRM predictive performance was determined in terms of area under the Receiver Operating Characteristic (ROC) curve (AUC), best cutoff, sensitivity, specificity, positive and negative predictive values, along with their asymptotic 95% confidence intervals (95% CI). One hundred ninety-one patents were admitted. HIIFRM was feasible in 147 cases (77%), 11 of which suffered a fall (7.5%). Failures in administration were mainly due to bedridden patients (e.g. minimally conscious state, vegetative state). AUC was 0.779(0.685-0.873). The original HIIFRM cutoff of 5 led to a sensitivity of 100% with a mere specificity of 49%(40-57%), thus suggesting using higher cutoffs. Moreover, the median score for non-fallers at rehabilitation units was higher than that reported in literature for geriatric non fallers. The best trade-off between sensitivity and specificity was obtained by using a cutoff of 8. This lead to sensitivity = 73%(46-99%), specificity = 72%(65-80%), positive predictive value = 17% and negative predictive value = 97%. These results support the use of the HIIFRM as a predictive tool. The HIIFRM showed satisfactory feasibility and predictive performances in

  6. EL ORO ES TRISTE

    Directory of Open Access Journals (Sweden)

    Jose María Corella Hurtado

    2012-01-01

    Full Text Available Esas narraciones eran las mismas cantaletas de mis abuelos, de mis tíos, de los negros y los mineros, contadas bajo las torrenciales noches de lluvia o bajo los indignos soles. Mi madre también relataba de memoria, como una cotorra y con la misma exactitud mientras realizaba los oficios domésticos, bien sean los de la barraca del puerto de Barbacoas o los de la casa de Pasto. Los barbacoanos de esa lejana generación, debieron soportar los recuerdos nefastos de la historia enquistada con dolor porque crecieron coreando episodios con la misma y sorprendente precisión. Era, es y será por siempre, una carcoma dolorosa y perseverante, aquello de la draga. Es que lo sucedido en Barbacoas no debe olvidarse y menos repetirse. Esos sucesos me comprometían de alguna manera; vividos unos en carne propia y a oídas otros que mezclaban el dolor que causó a los paisanos la pobreza en que quedaron.

  7. FREEZING AND THAWING TIME PREDICTION METHODS OF FOODS II: NUMARICAL METHODS

    Directory of Open Access Journals (Sweden)

    Yahya TÜLEK

    1999-03-01

    Full Text Available Freezing is one of the excellent methods for the preservation of foods. If freezing and thawing processes and frozen storage method are carried out correctly, the original characteristics of the foods can remain almost unchanged over an extended periods of time. It is very important to determine the freezing and thawing time period of the foods, as they strongly influence the both quality of food material and process productivity and the economy. For developing a simple and effectively usable mathematical model, less amount of process parameters and physical properties should be enrolled in calculations. But it is a difficult to have all of these in one prediction method. For this reason, various freezing and thawing time prediction methods were proposed in literature and research studies have been going on.

  8. Computational and experimental prediction of dust production in pebble bed reactors, Part II

    Energy Technology Data Exchange (ETDEWEB)

    Hiruta, Mie; Johnson, Gannon [Department of Mechanical Engineering, University of Idaho, 1776 Science Center Drive, Idaho Falls, ID 83401 (United States); Rostamian, Maziar, E-mail: mrostamian@asme.org [Department of Mechanical Engineering, University of Idaho, 1776 Science Center Drive, Idaho Falls, ID 83401 (United States); Potirniche, Gabriel P. [Department of Mechanical Engineering, University of Idaho, 1776 Science Center Drive, Idaho Falls, ID 83401 (United States); Ougouag, Abderrafi M. [Idaho National Laboratory, 2525 N Fremont Avenue, Idaho Falls, ID 83401 (United States); Bertino, Massimo; Franzel, Louis [Department of Physics, Virginia Commonwealth University, Richmond, VA 23284 (United States); Tokuhiro, Akira [Department of Mechanical Engineering, University of Idaho, 1776 Science Center Drive, Idaho Falls, ID 83401 (United States)

    2013-10-15

    Highlights: • Custom-built high temperature, high pressure tribometer is designed. • Two different wear phenomena at high temperatures are observed. • Experimental wear results for graphite are presented. • The graphite wear dust production in a typical Pebble Bed Reactor is predicted. -- Abstract: This paper is the continuation of Part I, which describes the high temperature and high pressure helium environment wear tests of graphite–graphite in frictional contact. In the present work, it has been attempted to simulate a Pebble Bed Reactor core environment as compared to Part I. The experimental apparatus, which is a custom-designed tribometer, is capable of performing wear tests at PBR relevant higher temperatures and pressures under a helium environment. This environment facilitates prediction of wear mass loss of graphite as dust particulates from the pebble bed. The experimental results of high temperature helium environment are used to anticipate the amount of wear mass produced in a pebble bed nuclear reactor.

  9. Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients

    DEFF Research Database (Denmark)

    Urup, Thomas; Michaelsen, Signe Regner; Olsen, Lars Rønn

    2016-01-01

    Background: Bevacizumab combination therapy is among the most frequently used treatments in recurrent glioblastoma and patients who achieve response to bevacizumab have improved survival as well as quality of life. Accordingly, the aim of this study was to identify predictive biomarkers for bevac......Background: Bevacizumab combination therapy is among the most frequently used treatments in recurrent glioblastoma and patients who achieve response to bevacizumab have improved survival as well as quality of life. Accordingly, the aim of this study was to identify predictive biomarkers...... for bevacizumab response in recurrent glioblastoma patients. Methods: The study included a total of 82 recurrent glioblastoma patients treated with bevacizumab combination therapy whom were both response and biomarker evaluable. Gene expression of tumor tissue was analyzed by using a customized Nano...

  10. A network-based predictive gene-expression signature for adjuvant chemotherapy benefit in stage II colorectal cancer.

    Science.gov (United States)

    Cao, Bangrong; Luo, Liping; Feng, Lin; Ma, Shiqi; Chen, Tingqing; Ren, Yuan; Zha, Xiao; Cheng, Shujun; Zhang, Kaitai; Chen, Changmin

    2017-12-13

    The clinical benefit of adjuvant chemotherapy for stage II colorectal cancer (CRC) is controversial. This study aimed to explore novel gene signature to predict outcome benefit of postoperative 5-Fu-based therapy in stage II CRC. Gene-expression profiles of stage II CRCs from two datasets with 5-Fu-based adjuvant chemotherapy (training dataset, n = 212; validation dataset, n = 85) were analyzed to identify the indicator. A systemic approach by integrating gene-expression and protein-protein interaction (PPI) network was implemented to develop the predictive signature. Kaplan-Meier curves and Cox proportional hazards model were used to determine the survival benefit of adjuvant chemotherapy. Experiments with shRNA knock-down were carried out to confirm the signature identified in this study. In the training dataset, we identified 44 PPI sub-modules, by which we separate patients into two clusters (1 and 2) having different chemotherapeutic benefit. A predictor of 11 PPI sub-modules (11-PPI-Mod) was established to discriminate the two sub-groups, with an overall accuracy of 90.1%. This signature was independently validated in an external validation dataset. Kaplan-Meier curves showed an improved outcome for patients who received adjuvant chemotherapy in Cluster 1 sub-group, but even worse survival for those in Cluster 2 sub-group. Similar results were found in both the training and the validation dataset. Multivariate Cox regression revealed an interaction effect between 11-PPI-Mod signature and adjuvant therapy treatment in the training dataset (RFS, p = 0.007; OS, p = 0.006) and the validation dataset (RFS, p = 0.002). From the signature, we found that PTGES gene was up-regulated in CRC cells which were more resistant to 5-Fu. Knock-down of PTGES indicated a growth inhibition and up-regulation of apoptotic markers induced by 5-Fu in CRC cells. Only a small proportion of stage II CRC patients could benefit from adjuvant therapy. The 11-PPI-Mod as

  11. El Futuro es Hoy

    Directory of Open Access Journals (Sweden)

    Alfonso Latiff Conde

    2002-08-01

    Full Text Available

    En ninguna otra época de la historia como en la nuestra se ha producido una transición tan rápida hacia el futuro, en el campo de la medicina.

    Lo que había sido una centuria de evolución desde la era Industrial a la era de la Informática, en la pasada década se ha convertido en una revolución.

    La cirugía laparoscopica que ha constituído el despertar a la edad de la informática como la tecnología lider es considerada ahora un standard en la práctica médica. En la actualidad tecnologias más avanzadas prometen mayores progresos en la medicina.

    La mayor revolución médica ocurrió en la cirugía en las postrimerias del siglo diecinueve cuando algunos gigantes de la medicina todavía caminaban sobre la tierra. Estos visionarios comprendieron la magnitud del cambio y dieron nacimiento a la nueva disciplina de la cirugía. Entre ellos estaban Bilroth, Lister, Virchow y Morton.

    Nunca trabajaron juntos, pero la integración espontánea de sus investigaciones y sus habilidades clínicas hicieron posible la nueva cirugía. Fue la convergencia de sus visiones y sus tecnologias las que dieron un vuelco a la cirugía. Bilroth aportó nuevas técnicas y nuevos instrumentos Lister aportó la asepsia, Virchow la patología y Morton la anestesia.

    Los antiguos mitos y muchos hechos empiricos hicieron creer por miles de años en la inviolabilidad del cuerpo humano. Las herramientas científicas de la Era Industrial convirtieron en realidad lo imposible y la ciencia dio nacimiento a la moderna cirugía. En un corto periodo de tiempo se establecieron los fundamentos de una cirugía que permitiría a las siguientes generaciones liderar nuevos avances y tecnologias.

    Nada estremeció más los fundamentos de la medicina como esta explosión de la cirugía. Comprender el shock, la cirugía cardiaca y coronaria, los trasplantes, tuvieron un enorme impacto que conmocionó la medicina. Es obvio que los cambios producidos

  12. IFPE/FUMEX-II/CASE27, 7 idealised cases for functional dependence of FGR predictions

    International Nuclear Information System (INIS)

    Turnbull, J.A.; Rossiter, Glyn; Sontheimer, Fritz; Tayal, Mukesh

    2004-01-01

    Description: Seven idealised cases to illustrate the functional dependence of fission gas release (FGR) predictions. (1) Temperature vs Bu for onset of FGR (draft available); (2a) FGR for constant 15 kW/m to 100 MWd/kgU; (2b) FGR for 20 kW/m at BOL decreasing linearly to 10 kW/m at 100 MWd/kgU; (2c) FGR for more realistic power histories supplied by BNFL; (2d) FGR for idealized 'real' histories supplied by FANP; (3a) Candu-Effect of Power on Fission Gas Release; (3b) Candu-Effect of Power Envelope on Fuel Performance

  13. Finite element analysis for prediction of the residual stresses induced by shot peening II

    International Nuclear Information System (INIS)

    Kim, Cheol; Seok, Chang Sung; Yang, Won Ho; Ryu, Myung Hai

    2002-01-01

    Shot peening is a surface impact treatment widely used to improve the performance of metal parts and welded details subjected to fatigue loading, contact fatigue, stress corrosion and other damage mechanisms. The better performance of the peened parts is mainly due to the residual stresses resulting from the plastic deformation of the surface layers of the material caused by the impact of the shot. In this paper the simulation technique is applied to predict the magnitude and distribution of the residual stress and plastic deformation caused by shot peening with the help of finite element analysis

  14. TSSPlant: a new tool for prediction of plant Pol II promoters

    KAUST Repository

    Shahmuradov, Ilham A.

    2017-01-13

    Our current knowledge of eukaryotic promoters indicates their complex architecture that is often composed of numerous functional motifs. Most of known promoters include multiple and in some cases mutually exclusive transcription start sites (TSSs). Moreover, TSS selection depends on cell/tissue, development stage and environmental conditions. Such complex promoter structures make their computational identification notoriously difficult. Here, we present TSSPlant, a novel tool that predicts both TATA and TATA-less promoters in sequences of a wide spectrum of plant genomes. The tool was developed by using large promoter collections from ppdb and PlantProm DB. It utilizes eighteen significant compositional and signal features of plant promoter sequences selected in this study, that feed the artificial neural network-based model trained by the backpropagation algorithm. TSSPlant achieves significantly higher accuracy compared to the next best promoter prediction program for both TATA promoters (MCC≃0.84 and F1-score≃0.91 versus MCC≃0.51 and F1-score≃0.71) and TATA-less promoters (MCC≃0.80, F1-score≃0.89 versus MCC≃0.29 and F1-score≃0.50). TSSPlant is available to download as a standalone program at http://www.cbrc.kaust.edu.sa/download/.

  15. TSSPlant: a new tool for prediction of plant Pol II promoters

    KAUST Repository

    Shahmuradov, Ilham A.; Umarov, Ramzan; Solovyev, Victor V.

    2017-01-01

    Our current knowledge of eukaryotic promoters indicates their complex architecture that is often composed of numerous functional motifs. Most of known promoters include multiple and in some cases mutually exclusive transcription start sites (TSSs). Moreover, TSS selection depends on cell/tissue, development stage and environmental conditions. Such complex promoter structures make their computational identification notoriously difficult. Here, we present TSSPlant, a novel tool that predicts both TATA and TATA-less promoters in sequences of a wide spectrum of plant genomes. The tool was developed by using large promoter collections from ppdb and PlantProm DB. It utilizes eighteen significant compositional and signal features of plant promoter sequences selected in this study, that feed the artificial neural network-based model trained by the backpropagation algorithm. TSSPlant achieves significantly higher accuracy compared to the next best promoter prediction program for both TATA promoters (MCC≃0.84 and F1-score≃0.91 versus MCC≃0.51 and F1-score≃0.71) and TATA-less promoters (MCC≃0.80, F1-score≃0.89 versus MCC≃0.29 and F1-score≃0.50). TSSPlant is available to download as a standalone program at http://www.cbrc.kaust.edu.sa/download/.

  16. Non-animal methods to predict skin sensitization (II): an assessment of defined approaches *.

    Science.gov (United States)

    Kleinstreuer, Nicole C; Hoffmann, Sebastian; Alépée, Nathalie; Allen, David; Ashikaga, Takao; Casey, Warren; Clouet, Elodie; Cluzel, Magalie; Desprez, Bertrand; Gellatly, Nichola; Göbel, Carsten; Kern, Petra S; Klaric, Martina; Kühnl, Jochen; Martinozzi-Teissier, Silvia; Mewes, Karsten; Miyazawa, Masaaki; Strickland, Judy; van Vliet, Erwin; Zang, Qingda; Petersohn, Dirk

    2018-05-01

    Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic understanding and concurrent necessity for non-animal testing approaches have evolved to a critical juncture, with many available options for predicting sensitization without using animals. Cosmetics Europe and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods collaborated to analyze the performance of multiple non-animal data integration approaches for the skin sensitization safety assessment of cosmetics ingredients. The Cosmetics Europe Skin Tolerance Task Force (STTF) collected and generated data on 128 substances in multiple in vitro and in chemico skin sensitization assays selected based on a systematic assessment by the STTF. These assays, together with certain in silico predictions, are key components of various non-animal testing strategies that have been submitted to the Organization for Economic Cooperation and Development as case studies for skin sensitization. Curated murine local lymph node assay (LLNA) and human skin sensitization data were used to evaluate the performance of six defined approaches, comprising eight non-animal testing strategies, for both hazard and potency characterization. Defined approaches examined included consensus methods, artificial neural networks, support vector machine models, Bayesian networks, and decision trees, most of which were reproduced using open source software tools. Multiple non-animal testing strategies incorporating in vitro, in chemico, and in silico inputs demonstrated equivalent or superior performance to the LLNA when compared to both animal and human data for skin sensitization.

  17. Making oxidation potentials predictable: Coordination of additives applied to the electronic fine tuning of an iron(II) complex

    KAUST Repository

    Haslinger, Stefan

    2014-11-03

    This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, which is also an excellent oxidation catalyst, is prone to axial ligand exchange. Phosphine- and pyridine-based additives are used for substitution of the acetonitrile ligands. On the basis of the resulting defined complexes, predictability of the oxidation potentials is demonstrated, based on a correlation between cyclic voltammetry experiments and density functional theory calculated molecular orbital energies. Fundamental insights into changes of the electronic properties upon axial ligand exchange and the impact on related attributes will finally lead to target-oriented manipulation of the electronic properties and consequently to the effective tuning of the reactivity of bioinspired systems.

  18. Making oxidation potentials predictable: Coordination of additives applied to the electronic fine tuning of an iron(II) complex

    KAUST Repository

    Haslinger, Stefan; Kü ck, Jens W.; Hahn, Eva M.; Cokoja, Mirza; Pö thig, Alexander; Basset, Jean-Marie; Kü hn, Fritz

    2014-01-01

    This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, which is also an excellent oxidation catalyst, is prone to axial ligand exchange. Phosphine- and pyridine-based additives are used for substitution of the acetonitrile ligands. On the basis of the resulting defined complexes, predictability of the oxidation potentials is demonstrated, based on a correlation between cyclic voltammetry experiments and density functional theory calculated molecular orbital energies. Fundamental insights into changes of the electronic properties upon axial ligand exchange and the impact on related attributes will finally lead to target-oriented manipulation of the electronic properties and consequently to the effective tuning of the reactivity of bioinspired systems.

  19. CRAB-II: a computer program to predict hydraulics and scram dynamics of LMFBR control assemblies and its validation

    International Nuclear Information System (INIS)

    Carelli, M.D.; Baker, L.A.; Willis, J.M.; Engel, F.C.; Nee, D.Y.

    1982-01-01

    This paper presents an analytical method, the computer code CRAB-II, which calculates the hydraulics and scram dynamics of LMFBR control assemblies of the rod bundle type and its validation against prototypic data obtained for the Clinch River Breeder Reactor (CRBR) primary control assemblies. The physical-mathematical model of the code is presented, followed by a description of the testing of prototypic CRBR control assemblies in water and sodium to characterize, respectively, their hydraulic and scram dynamics behavior. Comparison of code predictions against the experimental data are presened in detail; excellent agreement was found. Also reported are experimental data and empirical correlations for the friction factor of the absorber bundle in the entire flow range (laminar to turbulent) which represent an extension of the state-of-the-art, since only fuel and blanket assemblies friction factor correlations were previously reported in the open literature

  20. Design and verification of controllers for longitudinal oscillations using optimal control theory and numerical simulation: Predictions for PEP-II

    International Nuclear Information System (INIS)

    Hindi, H.; Prabhakar, S.; Fox, J.; Teytelman, D.

    1997-12-01

    The authors present a technique for the design and verification of efficient bunch-by-bunch controllers for damping longitudinal multibunch instabilities. The controllers attempt to optimize the use of available feedback amplifier power--one of the most expensive components of a feedback system--and define the limits of closed loop system performance. The design technique alternates between analytic computation of single bunch optimal controllers and verification on a multibunch numerical simulator. The simulator identifies unstable coupled bunch modes and predicts their growth and damping rates. The results from the simulator are shown to be in reasonable agreement with analytical calculations based on the single bunch model. The technique is then used to evaluate the performance of a variety of controllers proposed for PEP-II

  1. A quasi-stationary numerical model of atomized metal droplets, II: Prediction and assessment

    DEFF Research Database (Denmark)

    Pryds, Nini H.; Hattel, Jesper Henri; Thorborg, Jesper

    1999-01-01

    been illustrated.A comparison between the numerical model and the experimental results shows an excellent agreement and demonstrates the validity of the present model, e.g. the calculated gas temperature which has an important influence on the droplet solidification behaviour as well as the calculated......A new model which extends previous studies and includes the interaction between enveloping gas and an array of droplets has been developed and presented in a previous paper. The model incorporates the probability density function of atomized metallic droplets into the heat transfer equations....... The main thrust of the model is that the gas temperature was not predetermined and calculated empirically but calculated numerically based on heat balance consideration. In this paper, the accuracy of the numerical model and the applicability of the model as a predictive tool have been investigated...

  2. Computational and experimental prediction of dust production in pebble bed reactors, Part II

    Energy Technology Data Exchange (ETDEWEB)

    Mie Hiruta; Gannon Johnson; Maziar Rostamian; Gabriel P. Potirniche; Abderrafi M. Ougouag; Massimo Bertino; Louis Franzel; Akira Tokuhiro

    2013-10-01

    This paper is the continuation of Part I, which describes the high temperature and high pressure helium environment wear tests of graphite–graphite in frictional contact. In the present work, it has been attempted to simulate a Pebble Bed Reactor core environment as compared to Part I. The experimental apparatus, which is a custom-designed tribometer, is capable of performing wear tests at PBR relevant higher temperatures and pressures under a helium environment. This environment facilitates prediction of wear mass loss of graphite as dust particulates from the pebble bed. The experimental results of high temperature helium environment are used to anticipate the amount of wear mass produced in a pebble bed nuclear reactor.

  3. GUTs and exceptional branes in F-theory - II. Experimental predictions

    International Nuclear Information System (INIS)

    Beasley, Chris; Heckman, Jonathan J.; Vafa, Cumrun

    2009-01-01

    We consider realizations of GUT models in F-theory. Adopting a bottom up approach, the assumption that the dynamics of the GUT model can in principle decouple from Planck scale physics leads to a surprisingly predictive framework. An internal U(1) hypercharge flux Higgses the GUT group directly to the MSSM or to a flipped GUT model, a mechanism unavailable in heterotic models. This new ingredient automatically addresses a number of puzzles present in traditional GUT models. The internal U(1) hyperflux allows us to solve the doublet-triplet splitting problem, and explains the qualitative features of the distorted GUT mass relations for lighter generations due to the Aharanov-Bohm effect. These models typically come with nearly exact global symmetries which prevent bare μ terms and also forbid dangerous baryon number violating operators. Strong curvature around our brane leads to a repulsion mechanism for Landau wave functions for neutral fields. This leads to large hierarchies of the form exp(-c/ε 2γ ) where c and γ are order one parameters and ε ∼ α GUT -1 M GUT /M pl . This effect can simultaneously generate a viably small μ term as well as an acceptable Dirac neutrino mass on the order of 0.5 x 10 -2±0.5 eV. In another scenario, we find a modified seesaw mechanism which predicts that the light neutrinos have masses in the expected range while the Majorana mass term for the heavy neutrinos is ∼ 3 x 10 12±1.5 GeV. Communicating supersymmetry breaking to the MSSM can be elegantly realized through gauge mediation. In one scenario, the same repulsion mechanism also leads to messenger masses which are naturally much lighter than the GUT scale.

  4. Microcomputer based program for predicting heat transfer under reactor accident conditions. Volume II

    International Nuclear Information System (INIS)

    Cheng, S.C.; Groeneveld, D.C.; Leung, L.K.H.; Wong, Y.L.; Nguyen, C.

    1987-07-01

    A microcomputer based program called Heat Transfer Prediction Software (HTPS) has been developed. It calculates the heat transfer for tube and bundle geometries for steady state and transient conditions. This program is capable of providing the best estimated of the hot pin temperatures during slow transients for 37- and 28-element CANDU type fuel bundles. The program is designed for an IBM-PC AT/XT (or IBM-PC compatible computer) equipped with a Math Co-processor. The following input parameters are required: pressure, mass flux, hydraulic diameter, and quality. For the steady state case, the critical heat flux (CHF), the critical heat flux temperature, the minimum film boiling temperature, and the minimum film boiling heat flux are the primary outputs. With either the surface heat flux or wall temperature specified, the program determines the heat transfer regime and calculates the surface heat flux, wall temperature and heat transfer coefficient. For the slow transient case, the pressure, mass flux, quality, and volumetric heat generation rate are the time dependent input parameters are required to calculate the hot pin sheath temperatures and surface heat fluxes. A simple routine for generating properties has been developed for light water to support the above program. It contains correlations that have been verified for pressures ranging from 0.6kPa to 30 MPa, and temperatures up to 1100 degrees Celcius. The thermodynamic and transport properties that can be generated from this routine are: density, specific volume, enthalpy, specific heat capacity, conductivity, viscosity, surface tension and Prandtle number for saturated liquid, saturated vapour, subcooled liquid of superheated vapour. A software for predicting flow regime has also been developed. It determines the flow pattern at specific flow conditions, and provides a correction factor for calculating the CHF during partially stratified horizontal flow. The technical bases for the program and its structure

  5. PLANET-PLANET SCATTERING IN PLANETESIMAL DISKS. II. PREDICTIONS FOR OUTER EXTRASOLAR PLANETARY SYSTEMS

    International Nuclear Information System (INIS)

    Raymond, Sean N.; Armitage, Philip J.; Gorelick, Noel

    2010-01-01

    We develop an idealized dynamical model to predict the typical properties of outer extrasolar planetary systems, at radii comparable to the Jupiter-to-Neptune region of the solar system. The model is based upon the hypothesis that dynamical evolution in outer planetary systems is controlled by a combination of planet-planet scattering and planetary interactions with an exterior disk of small bodies ('planetesimals'). Our results are based on 5000 long duration N-body simulations that follow the evolution of three planets from a few to 10 AU, together with a planetesimal disk containing 50 M + from 10 to 20 AU. For large planet masses (M ∼> M Sat ), the model recovers the observed eccentricity distribution of extrasolar planets. For lower-mass planets, the range of outcomes in models with disks is far greater than that which is seen in isolated planet-planet scattering. Common outcomes include strong scattering among massive planets, sudden jumps in eccentricity due to resonance crossings driven by divergent migration, and re-circularization of scattered low-mass planets in the outer disk. We present the distributions of the eccentricity and inclination that result, and discuss how they vary with planet mass and initial system architecture. In agreement with other studies, we find that the currently observed eccentricity distribution (derived primarily from planets at a ∼ -1 and periods in excess of 10 years will provide constraints on this regime. Finally, we present an analysis of the predicted separation of planets in two-planet systems, and of the population of planets in mean-motion resonances (MMRs). We show that, if there are systems with ∼ Jupiter-mass planets that avoid close encounters, the planetesimal disk acts as a damping mechanism and populates MMRs at a very high rate (50%-80%). In many cases, resonant chains (in particular the 4:2:1 Laplace resonance) are set up among all three planets. We expect such resonant chains to be common among massive

  6. Identification and Construction of Combinatory Cancer Hallmark-Based Gene Signature Sets to Predict Recurrence and Chemotherapy Benefit in Stage II Colorectal Cancer.

    Science.gov (United States)

    Gao, Shanwu; Tibiche, Chabane; Zou, Jinfeng; Zaman, Naif; Trifiro, Mark; O'Connor-McCourt, Maureen; Wang, Edwin

    2016-01-01

    Decisions regarding adjuvant therapy in patients with stage II colorectal cancer (CRC) have been among the most challenging and controversial in oncology over the past 20 years. To develop robust combinatory cancer hallmark-based gene signature sets (CSS sets) that more accurately predict prognosis and identify a subset of patients with stage II CRC who could gain survival benefits from adjuvant chemotherapy. Thirteen retrospective studies of patients with stage II CRC who had clinical follow-up and adjuvant chemotherapy were analyzed. Respective totals of 162 and 843 patients from 2 and 11 independent cohorts were used as the discovery and validation cohorts, respectively. A total of 1005 patients with stage II CRC were included in the 13 cohorts. Among them, 84 of 416 patients in 3 independent cohorts received fluorouracil-based adjuvant chemotherapy. Identification of CSS sets to predict relapse-free survival and identify a subset of patients with stage II CRC who could gain substantial survival benefits from fluorouracil-based adjuvant chemotherapy. Eight cancer hallmark-based gene signatures (30 genes each) were identified and used to construct CSS sets for determining prognosis. The CSS sets were validated in 11 independent cohorts of 767 patients with stage II CRC who did not receive adjuvant chemotherapy. The CSS sets accurately stratified patients into low-, intermediate-, and high-risk groups. Five-year relapse-free survival rates were 94%, 78%, and 45%, respectively, representing 60%, 28%, and 12% of patients with stage II disease. The 416 patients with CSS set-defined high-risk stage II CRC who received fluorouracil-based adjuvant chemotherapy showed a substantial gain in survival benefits from the treatment (ie, recurrence reduced by 30%-40% in 5 years). The CSS sets substantially outperformed other prognostic predictors of stage 2 CRC. They are more accurate and robust for prognostic predictions and facilitate the identification of patients with stage

  7. An Assessment of Comprehensive Code Prediction State-of-the-Art Using the HART II International Workshop Data

    Science.gov (United States)

    vanderWall, Berend G.; Lim, Joon W.; Smith, Marilyn J.; Jung, Sung N.; Bailly, Joelle; Baeder, James D.; Boyd, D. Douglas, Jr.

    2012-01-01

    Despite significant advancements in computational fluid dynamics and their coupling with computational structural dynamics (= CSD, or comprehensive codes) for rotorcraft applications, CSD codes with their engineering level of modeling the rotor blade dynamics, the unsteady sectional aerodynamics and the vortical wake are still the workhorse for the majority of applications. This is especially true when a large number of parameter variations is to be performed and their impact on performance, structural loads, vibration and noise is to be judged in an approximate yet reliable and as accurate as possible manner. In this paper, the capabilities of such codes are evaluated using the HART II Inter- national Workshop data base, focusing on a typical descent operating condition which includes strong blade-vortex interactions. Three cases are of interest: the baseline case and two cases with 3/rev higher harmonic blade root pitch control (HHC) with different control phases employed. One setting is for minimum blade-vortex interaction noise radiation and the other one for minimum vibration generation. The challenge is to correctly predict the wake physics - especially for the cases with HHC - and all the dynamics, aerodynamics, modifications of the wake structure and the aero-acoustics coming with it. It is observed that the comprehensive codes used today have a surprisingly good predictive capability when they appropriately account for all of the physics involved. The minimum requirements to obtain these results are outlined.

  8. The HART II International Workshop: An Assessment of the State-of-the-Art in Comprehensive Code Prediction

    Science.gov (United States)

    vanderWall, Berend G.; Lim, Joon W.; Smith, Marilyn J.; Jung, Sung N.; Bailly, Joelle; Baeder, James D.; Boyd, D. Douglas, Jr.

    2013-01-01

    Significant advancements in computational fluid dynamics (CFD) and their coupling with computational structural dynamics (CSD, or comprehensive codes) for rotorcraft applications have been achieved recently. Despite this, CSD codes with their engineering level of modeling the rotor blade dynamics, the unsteady sectional aerodynamics and the vortical wake are still the workhorse for the majority of applications. This is especially true when a large number of parameter variations is to be performed and their impact on performance, structural loads, vibration and noise is to be judged in an approximate yet reliable and as accurate as possible manner. In this article, the capabilities of such codes are evaluated using the HART II International Workshop database, focusing on a typical descent operating condition which includes strong blade-vortex interactions. A companion article addresses the CFD/CSD coupled approach. Three cases are of interest: the baseline case and two cases with 3/rev higher harmonic blade root pitch control (HHC) with different control phases employed. One setting is for minimum blade-vortex interaction noise radiation and the other one for minimum vibration generation. The challenge is to correctly predict the wake physics-especially for the cases with HHC-and all the dynamics, aerodynamics, modifications of the wake structure and the aero-acoustics coming with it. It is observed that the comprehensive codes used today have a surprisingly good predictive capability when they appropriately account for all of the physics involved. The minimum requirements to obtain these results are outlined.

  9. Etude des bactéries acétiques isolées de raisins et de vins - II.- Production de composés cétoniques

    Directory of Open Access Journals (Sweden)

    A.C. BLACKWOOD

    1969-09-01

    Full Text Available La deuxième partie de ce travail sur les bactéries acétiques isolées de raisins et de vins est consacrée à l'étude de deux problèmes principaux : d'une part l'identification par chromatographie sur papier des principales substances cétoniques réductrices, d'autre part la détermination de l'influence de divers facteurs sur la croissance des souches représentatives de chaque groupe taxonomique.

  10. A Comparison of a Machine Learning Model with EuroSCORE II in Predicting Mortality after Elective Cardiac Surgery: A Decision Curve Analysis.

    Science.gov (United States)

    Allyn, Jérôme; Allou, Nicolas; Augustin, Pascal; Philip, Ivan; Martinet, Olivier; Belghiti, Myriem; Provenchere, Sophie; Montravers, Philippe; Ferdynus, Cyril

    2017-01-01

    The benefits of cardiac surgery are sometimes difficult to predict and the decision to operate on a given individual is complex. Machine Learning and Decision Curve Analysis (DCA) are recent methods developed to create and evaluate prediction models. We conducted a retrospective cohort study using a prospective collected database from December 2005 to December 2012, from a cardiac surgical center at University Hospital. The different models of prediction of mortality in-hospital after elective cardiac surgery, including EuroSCORE II, a logistic regression model and a machine learning model, were compared by ROC and DCA. Of the 6,520 patients having elective cardiac surgery with cardiopulmonary bypass, 6.3% died. Mean age was 63.4 years old (standard deviation 14.4), and mean EuroSCORE II was 3.7 (4.8) %. The area under ROC curve (IC95%) for the machine learning model (0.795 (0.755-0.834)) was significantly higher than EuroSCORE II or the logistic regression model (respectively, 0.737 (0.691-0.783) and 0.742 (0.698-0.785), p machine learning model, in this monocentric study, has a greater benefit whatever the probability threshold. According to ROC and DCA, machine learning model is more accurate in predicting mortality after elective cardiac surgery than EuroSCORE II. These results confirm the use of machine learning methods in the field of medical prediction.

  11. A Novel Procedure for Prediction of Mixed Mode I/II in Fracture Toughness of Laminate Composites

    Directory of Open Access Journals (Sweden)

    M. Mahmood Shokrieh

    2014-06-01

    Full Text Available Delamination is one of the important modes of failure in laminated composite materials. In this respect, the mixed mode I/II fracture is the most major mode of delamination incidence in laminated composite. In the present research, a relation between the fracture toughness of double cantilever beam (DCB and asymmetric double cantilever beam (ADCB specimens is presented. The DCB and ADCB samples are used for measuring the mode I and mixed mode I/II fracture toughness (G of laminated composite materials, respectively. By considering the diversity of the stacking sequence of lay-ups, the test performance on all different types of lay-ups in order to measure the fracture toughness of laminated composites is a tedious, costly and time consuming task. The purpose of deriving this relation is to estimate the value of the strain energy release rate of laminated composite ADCB specimens by testing a unidirectional DCB. To develop this relationship, the geometry of DCB and ADCB specimens are considered to obtain fracture toughness of multi-directional laminate composites of ADCB samples with arbitrary ply sequence which may be used for design purposes. The procedure presented here reduces the calculation costs of the finite element modeling and its corresponding test significantly. The results obtained by this method are compared with those of experimental and numerical methods. It is shown that the fracture toughness of multi-directional lay-ups can be predicted by measuring the unidirectional ply with an error less than 10% demonstrating the accuracy of the procedure developed in the present research.

  12. Prediction of Mortality after Emergent Transjugular Intrahepatic Portosystemic Shunt Placement: Use of APACHE II, Child-Pugh and MELD Scores in Asian Patients with Refractory Variceal Hemorrhage

    International Nuclear Information System (INIS)

    Tzeng, Wen Sheng; Wu, Reng Hong; Lin, Ching Yih; Chen, Jyh Jou; Sheu, Ming Juen; Koay, Lok Beng; Lee, Chuan

    2009-01-01

    This study was designed to determine if existing methods of grading liver function that have been developed in non-Asian patients with cirrhosis can be used to predict mortality in Asian patients treated for refractory variceal hemorrhage by the use of the transjugular intrahepatic portosystemic shunt (TIPS) procedure. Data for 107 consecutive patients who underwent an emergency TIPS procedure were retrospectively analyzed. Acute physiology and chronic health evaluation (APACHE II), Child-Pugh and model for end-stage liver disease (MELD) scores were calculated. Survival analyses were performed to evaluate the ability of the various models to predict 30-day, 60-day and 360-day mortality. The ability of stratified APACHE II, Child-Pugh, and MELD scores to predict survival was assessed by the use of Kaplan-Meier analysis with the log-rank test. No patient died during the TIPS procedure, but 82 patients died during the follow-up period. Thirty patients died within 30 days after the TIPS procedure; 37 patients died within 60 days and 53 patients died within 360 days. Univariate analysis indicated that hepatorenal syndrome, use of inotropic agents and mechanical ventilation were associated with elevated 30-day mortality (p 11 or an MELD score > 20 predicted increased risk of death at 30, 60 and 360 days (p 11 or an MELD score > 20 are predictive of mortality in Asian patients with refractory variceal hemorrhage treated with the TIPS procedure. An APACHE II score is not predictive of early mortality in this patient population

  13. Preparing to predict: The Second Autonomous Ocean Sampling Network (AOSN-II) experiment in the Monterey Bay

    Science.gov (United States)

    Ramp, S. R.; Davis, R. E.; Leonard, N. E.; Shulman, I.; Chao, Y.; Robinson, A. R.; Marsden, J.; Lermusiaux, P. F. J.; Fratantoni, D. M.; Paduan, J. D.; Chavez, F. P.; Bahr, F. L.; Liang, S.; Leslie, W.; Li, Z.

    2009-02-01

    The Autonomous Ocean Sampling Network Phase Two (AOSN-II) experiment was conducted in and offshore from the Monterey Bay on the central California coast during July 23-September 6, 2003. The objective of the experiment was to learn how to apply new tools, technologies, and analysis techniques to adaptively sample the coastal ocean in a manner demonstrably superior to traditional methodologies, and to use the information gathered to improve predictive skill for quantities of interest to end-users. The scientific goal was to study the upwelling/relaxation cycle near an open coastal bay in an eastern boundary current region, particularly as it developed and spread from a coastal headland. The suite of observational tools used included a low-flying aircraft, a fleet of underwater gliders, including several under adaptive autonomous control, and propeller-driven AUVs in addition to moorings, ships, and other more traditional hardware. The data were delivered in real time and assimilated into the Harvard Ocean Prediction System (HOPS), the Navy Coastal Ocean Model (NCOM), and the Jet Propulsion Laboratory implementation of the Regional Ocean Modeling System (JPL/ROMS). Two upwelling events and one relaxation event were sampled during the experiment. The upwelling in both cases began when a pool of cold water less than 13 °C appeared near Cape Año Nuevo and subsequently spread offshore and southward across the bay as the equatorward wind stress continued. The primary difference between the events was that the first event spread offshore and southward, while the second event spread only southward and not offshore. The difference is attributed to the position and strength of meanders and eddies of the California Current System offshore, which blocked or steered the cold upwelled water. The space and time scales of the mesoscale variability were much shorter than have been previously observed in deep-water eddies offshore. Additional process studies are needed to elucidate

  14. Prediction of Mortality after Emergent Transjugular Intrahepatic Portosystemic Shunt Placement: Use of APACHE II, Child-Pugh and MELD Scores in Asian Patients with Refractory Variceal Hemorrhage

    Energy Technology Data Exchange (ETDEWEB)

    Tzeng, Wen Sheng; Wu, Reng Hong; Lin, Ching Yih; Chen, Jyh Jou; Sheu, Ming Juen; Koay, Lok Beng; Lee, Chuan [Chi-Mei Foundation Medical Center, Tainan (China)

    2009-10-15

    This study was designed to determine if existing methods of grading liver function that have been developed in non-Asian patients with cirrhosis can be used to predict mortality in Asian patients treated for refractory variceal hemorrhage by the use of the transjugular intrahepatic portosystemic shunt (TIPS) procedure. Data for 107 consecutive patients who underwent an emergency TIPS procedure were retrospectively analyzed. Acute physiology and chronic health evaluation (APACHE II), Child-Pugh and model for end-stage liver disease (MELD) scores were calculated. Survival analyses were performed to evaluate the ability of the various models to predict 30-day, 60-day and 360-day mortality. The ability of stratified APACHE II, Child-Pugh, and MELD scores to predict survival was assessed by the use of Kaplan-Meier analysis with the log-rank test. No patient died during the TIPS procedure, but 82 patients died during the follow-up period. Thirty patients died within 30 days after the TIPS procedure; 37 patients died within 60 days and 53 patients died within 360 days. Univariate analysis indicated that hepatorenal syndrome, use of inotropic agents and mechanical ventilation were associated with elevated 30-day mortality (p < 0.05). Multivariate analysis showed that a Child-Pugh score > 11 or an MELD score > 20 predicted increased risk of death at 30, 60 and 360 days (p < 0.05). APACHE II scores could only predict mortality at 360 days (p < 0.05). A Child-Pugh score > 11 or an MELD score > 20 are predictive of mortality in Asian patients with refractory variceal hemorrhage treated with the TIPS procedure. An APACHE II score is not predictive of early mortality in this patient population.

  15. Vijana Vijiweni II: a cluster-randomized trial to evaluate the efficacy of a microfinance and peer health leadership intervention for HIV and intimate partner violence prevention among social networks of young men in Dar es Salaam.

    Science.gov (United States)

    Kajula, Lusajo; Balvanz, Peter; Kilonzo, Mrema Noel; Mwikoko, Gema; Yamanis, Thespina; Mulawa, Marta; Kajuna, Deus; Hill, Lauren; Conserve, Donaldson; Reyes, Heathe Luz McNaughton; Leatherman, Sheila; Singh, Basant; Maman, Suzanne

    2016-02-03

    Intimate partner violence (IPV) and sexually transmitted infections (STIs), including HIV, remain important public health problems with devastating health effects for men and women in sub-Saharan Africa. There have been calls to engage men in prevention efforts, however, we lack effective approaches to reach and engage them. Social network approaches have demonstrated effective and sustained outcomes on changing risk behaviors in the U.S. Our team has identified and engaged naturally occurring social networks comprised mostly of young men in Dar es Salaam in an intervention designed to jointly reduce STI incidence and the perpetration of IPV. These stable networks are locally referred to as "camps." In a pilot study we demonstrated the feasibility and acceptability of a combined microfinance and peer health leadership intervention within these camp-based peer networks. We are implementing a cluster-randomized trial to evaluate the efficacy of an intervention combining microfinance with health leadership training in 60 camps in Dar es Salaam, Tanzania. Half of the camps have been randomized to the intervention arm, and half to a control arm. The camps in the intervention arm will receive a combined microfinance and health leadership intervention for a period of two years. The camps in the control arm will receive a delayed intervention. We have enrolled 1,258 men across the 60 study camps. Behavioral surveys will be conducted at baseline, 12-months post intervention launch and 30-month post intervention launch and biological samples will be drawn to test for Neisseria gonorrhea (NG), Chlamydia trachomatis (CT), and Trichomonas vaginalis (TV) at baseline and 30-months. The primary endpoints for assessing intervention impact are IPV perpetration and STI incidence. This is the first cluster-randomized trial targeting social networks of men in sub-Saharan Africa that jointly addresses HIV and IPV perpetration and has both biological and behavioral endpoints. Effective

  16. BIOSSORÇÃO DE Pb(II POR CASCA DE URUCUM (Bixa orellana EM SOLUÇÕES AQUOSAS: ESTUDO CINÉTICO, EQUILÍBRIO E TERMODINÂMICO

    Directory of Open Access Journals (Sweden)

    Klaiani B. Fontana

    Full Text Available This study describes the application of new and low cost biosorbent, shells of urucum (Bixa Orellana, for removal of lead ions (Pb(II from water solution. The urucum shells were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy techniques. Batch adsorption experiments were performed in order to evaluate the effect of pH, agitation speed, adsorbent dosage, contact time, temperature, presence of interfering ions and matrix effect on the adsorption of process. The kinetics of biosorption followed pseudo-second-order model. Langmuir and Freundlich isotherm models were applied to describe the biosorption of Pb(II by urucum shells. The Langmuir model showed better fit and the estimated biosorption capacity was 43.6 mg g-1. The negative Gibbs free energy, ΔG°, confirms the spontaneous nature and positive value of enthalpy, ΔH°, the endothermic character of the process. Furthermore, we also performed an evaluation of matrix and others ions effect on the biosorption process.

  17. A Comparison of Predictive Thermo and Water Solvation Property Prediction Tools and Experimental Data for Selected Traditional Chemical Warfare Agents and Simulants II: COSMO RS and COSMOTherm

    Science.gov (United States)

    2017-04-01

    SELECTED TRADITIONAL CHEMICAL WARFARE AGENTS AND SIMULANTS II: COSMO-RS AND COSMOTHERM ECBC-TR-1454 Jerry B. Cabalo RESEARCH AND TECHNOLOGY...Traditional Chemical Warfare Agents and Simulants II: COSMO-RS and COSMOTherm 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER CB10115...in the ADF 2012 suite of programs for the physico- chemical properties of a set of traditional chemical warfare agents and selected simulants. To

  18. OS DISCURSOS SOBRE CURRÍCULO E AS CONCEPÇÕES DE AVALIAÇÃO NOS I E II SEGMENTOS DO ENSINO FUNDAMENTAL DA REDE MUNICIPAL DE JOÃO PESSOA/PB

    Directory of Open Access Journals (Sweden)

    Maria Zuleide da Costa Pereira; Francisco Alex Pereira Soares

    2016-01-01

    Full Text Available O presente texto aborda o plano II do projeto intitulado CURRÍCULO E AVALIAÇÃO: discursos contemporâneos (Os discursos sobre currículo e as concepções de avaliação nos I e II segmentos do Ensino Fundamental da Rede Municipal de João Pessoa/PB, realizado pelo programa PIBIC/PIVIC concretizado no período de 2014/2015, tendo como objetivo uma análise dos sentidos de avaliação e como estes estão articulados com os sentidos de currículo nas escolas municipais de João Pessoa. Para tanto e objetivando o alcance do objetivo proposto, esta pesquisa aproxima-se de autores do campo do currículo, como Pereira (2009a, b que assume o currículo como redes de significações, bem como em outros autores desse campo de estudo: Moreira e Candau (2007, Silva (2013. No tocante à avaliação, está embasada em Fernandes e Freitas (2007, Mainardes (2010, Esteban (2010. A pesquisa assume características quanti-qualitativa, de campo, bibliográfica, documental, exploratória e explicativa de acordo com Gonçalves (2003 e Marconi e Lakatos (2003. Para a compreensão dos sentidos de avaliação nos documentos analisados, foi utilizada a linguística de corpus, baseada nos estudos de Sardinha (2000, 2009, 2006 e, para auxiliar na linguística de corpus, foi utilizado o programa WordSmith Tool 6. Para a compreensão dos sentidos, lançou-se mão da Teoria do Discurso de Laclau (2005 e Laclau e Mouffe (2004 e de estudos de autores que se fundam nessa teoria, como Pereira (2009 a, b, Mendonça (2009, Ferreira (2011, entre outros. Os documentos analisados foram a Lei de Diretrizes e Bases da Educação, Diretrizes Curriculares Nacionais para o Ensino Fundamental, Parâmetros Curriculares Nacionais, Plano Municipal de Educação de João Pessoa, PPP de escolas da rede de ensino municipal de João Pessoa/PB e entrevistas feitas com professores. Foram utilizados trabalhos anteriores realizados com o intuito de saber os sentidos de currículo nas escolas da

  19. In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen.

    Science.gov (United States)

    Tsume, Yasuhiro; Langguth, Peter; Garcia-Arieta, Alfredo; Amidon, Gordon L

    2012-10-01

    The FDA Biopharmaceutical Classification System guidance allows waivers for in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage forms only for BCS class I. Extensions of the in vivo biowaiver for a number of drugs in BCS class III and BCS class II have been proposed, in particular, BCS class II weak acids. However, a discrepancy between the in vivo BE results and in vitro dissolution results for BCS class II acids was recently observed. The objectives of this study were to determine the oral absorption of BCS class II weak acids via simulation software and to determine if the in vitro dissolution test with various dissolution media could be sufficient for in vitro bioequivalence studies of ibuprofen and ketoprofen as models of carboxylic acid drugs. The oral absorption of these BCS class II acids from the gastrointestinal tract was predicted by GastroPlus™. Ibuprofen did not satisfy the bioequivalence criteria at lower settings of intestinal pH of 6.0. Further the experimental dissolution of ibuprofen tablets in a low concentration phosphate buffer at pH 6.0 (the average buffer capacity 2.2 mmol l (-1) /pH) was dramatically reduced compared with the dissolution in SIF (the average buffer capacity 12.6 mmol l (-1) /pH). Thus these predictions for the oral absorption of BCS class II acids indicate that the absorption patterns depend largely on the intestinal pH and buffer strength and must be considered carefully for a bioequivalence test. Simulation software may be a very useful tool to aid the selection of dissolution media that may be useful in setting an in vitro bioequivalence dissolution standard. Copyright © 2012 John Wiley & Sons, Ltd.

  20. In Silico Prediction of Drug Dissolution and Absorption with variation in Intestinal pH for BCS Class II Weak Acid Drugs: Ibuprofen and Ketoprofen§

    Science.gov (United States)

    Tsume, Yasuhiro; Langguth, Peter; Garcia-Arieta, Alfredo; Amidon, Gordon L.

    2012-01-01

    The FDA Biopharmaceutical Classification System guidance allows waivers for in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage forms only for BCS class I. Extensions of the in vivo biowaiver for a number of drugs in BCS Class III and BCS class II have been proposed, particularly, BCS class II weak acids. However, a discrepancy between the in vivo- BE results and in vitro- dissolution results for a BCS class II acids was recently observed. The objectives of this study were to determine the oral absorption of BCS class II weak acids via simulation software and to determine if the in vitro dissolution test with various dissolution media could be sufficient for in vitro bioequivalence studies of ibuprofen and ketoprofen as models of carboxylic acid drugs. The oral absorption of these BCS class II acids from the gastrointestinal tract was predicted by GastroPlus™. Ibuprofen did not satisfy the bioequivalence criteria at lower settings of intestinal pH=6.0. Further the experimental dissolution of ibuprofen tablets in the low concentration phosphate buffer at pH 6.0 (the average buffer capacity 2.2 mmol L-1/pH) was dramatically reduced compared to the dissolution in SIF (the average buffer capacity 12.6 mmol L -1/pH). Thus these predictions for oral absorption of BCS class II acids indicate that the absorption patterns largely depend on the intestinal pH and buffer strength and must be carefully considered for a bioequivalence test. Simulation software may be very useful tool to aid the selection of dissolution media that may be useful in setting an in vitro bioequivalence dissolution standard. PMID:22815122

  1. Predictive value of pretreatment lymphocyte count in stage II colorectal cancer and in high-risk patients treated with adjuvant chemotherapy.

    Science.gov (United States)

    Liang, Lei; Zhu, Ji; Jia, Huixun; Huang, Liyong; Li, Dawei; Li, Qingguo; Li, Xinxiang

    2016-01-05

    Pretreatment lymphocyte count (LC) has been associated with prognosis and chemotherapy response in several cancers. The predictive value of LC for stage II colorectal cancer (CRC) and for high-risk patients treated with adjuvant chemotherapy (AC) has not been determined. A retrospective review of prospectively collected data from 1332 consecutive stage II CRC patients who underwent curative tumor resection was conducted. A pretreatment LC value risk, 459 (62.2%) of whom received AC. Patients with low LCs had significantly worse 5-year OS (74.6% vs. 90.2%, p risk patients with low LCs had the poorest DFS (p value or combined with high-risk status were both independent prognostic factors(p risk, AC-treated patients with high LCs had significantly longer DFS than untreated patients (HR, 0.594; 95% CI, 0.364-0.970; p = 0.035). There was no difference or trend for DFS or OS in patients with low LCs, regardless of the use of AC (DFS, p = 0.692; OS, p = 0.522). Low LC was also independently associated with poorer DFS in high-risk, AC-treated patients (HR, 1.885; 95% CI, 1.112-3.196; p = 0.019). Pretreatment LC is an independent prognostic factor for survival in stage II CRC. Furthermore, pretreatment LC reliably predicts chemotherapeutic efficacy in high-risk patients with stage II CRC.

  2. es

    Directory of Open Access Journals (Sweden)

    Esther Bernal Valls

    Full Text Available El uso de ejercicios en el tratamiento de pacientes con déficit vestibular crónico está incrementándose de forma notable, lo que evidencia que se trata de un procedimiento que resulta beneficioso para este tipo de pacientes. Los buenos resultados que se obtienen sugieren que los ejercicios vestibulares dan lugar a una estabilidad postural y a una disminución de la sensación de desequilibrio.

  3. Magnetic resonance imaging versus Acute Physiology And Chronic Healthy Evaluation II score in predicting the severity of acute pancreatitis

    International Nuclear Information System (INIS)

    Tang Wei; Zhang Xiaoming; Xiao Bo; Zeng Nanlin; Pan Huashan; Feng Zhisong; Xu Xiaoxue

    2011-01-01

    Objective: To study the correlation between established magnetic resonance (MR) imaging criteria of disease severity in acute pancreatitis and the Acute Physiology And Chronic Healthy Evaluation II (APACHE II) score, and to assess the utility of each prognostic indicators in acute pancreatitis. Materials and methods: In this study there were 94 patients with acute pancreatitis (AP), all had abdominal MR imaging. MR findings were categorized into edematous and necrotizing AP and graded according to the MR severity index (MRSI). The APACHE II score was calculated within 24 h of admission, and local complications, death, duration of hospitalization and ICU were recorded. Statistical analysis was performed to determine their correlation. Results: In patients with pancreatitis, no significant correlation can be found between the APACHE II score and the MRSI score (P = 0.196). The MRSI score correlated well with morbidity (P = 0.006) but not with mortality (P = 0.137). The APACHE II score correlated well with mortality (P = 0.002) but not with the morbidity (P = 0.112). The MRSI score was superior to the APACHE II score as a predictor of the length of hospitalization (r = 0.52 vs. r = 0.35). A high MRSI and APACHE II score correlated with the need for being in the intensive care unit (ICU) (P = 0.000 and P = 0.000, respectively). Conclusion: In patients with pancreatitis, MRSI is superior to APACHE II in assessing local complications from pancreatitis but has a limited role in determining systemic complications in which the APACHE II score excels.

  4. ES-2 Dummy Biomechanical Responses.

    Science.gov (United States)

    Byrnes, Katie; Abramczyk, Joseph; Berliner, Jeff; Irwin, Annette; Jensen, Jack; Kowsika, Murthy; Mertz, Harold J; Rouhana, Stephen W; Scherer, Risa; Shi, Yibing; Sutterfield, Aleta; Xu, Lan; Tylko, Suzanne; Dalmotas, Dainius

    2002-11-01

    This technical paper presents the results of biomechanical testing conducted on the ES-2 dummy by the Occupant Safety Research Partnership and Transport Canada. The ES-2 is a production dummy, based on the EuroSID-1 dummy, that was modified to further improve testing capabilities as recommended by users of the EuroSID-1 dummy. Biomechanical response data were obtained by completing a series of drop, pendulum, and sled tests that are outlined in the International Organization of Standardization Technical Report 9790 that describes biofidelity requirements for the midsize adult male side impact dummy. A few of the biofidelity tests were conducted on both sides of the dummy to evaluate the symmetry of its responses. Full vehicle crash tests were conducted to verify if the changes in the EuroSID-1, resulting in the ES-2 design, did improve the dummy's testing capability. In addition to the biofidelity testing, the ES-2 dummy repeatability, reproducibility and durability are discussed. Finally, this technical paper will compare the biofidelity ratings of the current adult side impact dummies with the ES-2 dummy, which received an overall dummy biofidelity rating of 4.6.

  5. DARWIN-HC: A Tool to Predict Hot Corrosion of Nickel-Based Turbine Disks, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Hot Corrosion of turbine engine components has been studied for many years. The underlying mechan-isms of Type I Hot Corrosion and Type II Hot Corrosion are...

  6. Predictive value of PET-CT for pathological response in stages II and III breast cancer patients following neoadjuvant chemotherapy with docetaxel.

    Science.gov (United States)

    García García-Esquinas, Marta A; Arrazola García, Juan; García-Sáenz, José A; Furió-Bacete, V; Fuentes Ferrer, Manuel E; Ortega Candil, Aída; Cabrera Martín, María N; Carreras Delgado, José L

    2014-01-01

    To prospectively study the value of PET-CT with fluorine-18 fluorodeoxyglucose (FDG) to predict neoadjuvant chemotherapy (NAC) response of locoregional disease of stages II and III breast cancer patients. A written informed consent and approval were obtained from the Ethics Committee. PET-CT accuracy in the prediction of pathologic complete response (pCR) after NAC was studied in primary tumors and lymph node metastasis in 43 women (mean age: 50 years: range: 27-71 years) with histologically proven breast cancer between December 2009 and January 2011. PET-CT was performed at baseline and after NAC. SUV(max) percentage changes (ΔSUV(max)) were compared with pathology findings at surgery. Receiver-operator characteristic (ROC) analysis was used to discriminate between locoregional pCR and non-pCR. In patients not achieving pCR, it was investigated if ΔSUV(max) could accurately identify the residual cancer burden (RCB) classes: RCB-I (minimal residual disease (MRD)), RCB-II (moderate RD), and RCB-III (extensive RD). pCR was obtained in 11 patients (25.6%). Residual disease was found in 32 patients (74.4%): 16 (37.2%) RCB-I, 15 (35.6%) RCB-II and 2 (4.7%) RCB-III. Sensitivity, specificity, and accuracy to predict pCR were 90.9%, 90.6%, and 90.7%, respectively. Specificity was 94.1% in the identification of a subset of patients who had either pCR or MRD. Accuracy of ΔSUV(max) in the locoregional disease of stages II and III breast cancer patients after NAC is high for the identification of pCR cases. Its specificity is potentially sufficient to identify a subgroup of patients who could be managed with conservative surgery. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  7. Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning.

    Science.gov (United States)

    Liu, Xiao-Wei; Ma, Tao; Li, Lu-Lu; Qu, Bo; Liu, Zhi

    2017-07-01

    The present study investigated the predictive values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and Acute Physiology and Chronic Health Evaluation (APACHE) II score in the prognosis of patients with acute PQ poisoning. A total of 194 patients with acute PQ poisoning, hospitalized between April 2012 and January 2014 at the First Affiliated Hospital of P.R. China Medical University (Shenyang, China), were selected and divided into survival and mortality groups. Logistic regression analysis, receiver operator characteristic (ROC) curve analysis and Kaplan-Meier curve were applied to evaluate the values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and (APACHE) II score for predicting the prognosis of patients with acute PQ poisoning. Initial urine PQ concentration (C0), dose of poison, arterial blood lactate and APACHE II score of patients in the mortality group were significantly higher compared with the survival group (all Ppoison and arterial blood lactate correlated with mortality risk of acute PQ poisoning (all Ppoison, arterial blood lactate and APACHE II score in predicting the mortality of patients within 28 days were 0.921, 0.887, 0.808 and 0.648, respectively. The AUC of C0 for predicting early and delayed mortality were 0.890 and 0.764, respectively. The AUC values of urine paraquat concentration the day after poisoning (Csec) and the rebound rate of urine paraquat concentration in predicting the mortality of patients within 28 days were 0.919 and 0.805, respectively. The 28-day survival rate of patients with C0 ≤32.2 µg/ml (42/71; 59.2%) was significantly higher when compared with patients with C0 >32.2 µg/ml (38/123; 30.9%). These results suggest that the initial urine PQ concentration may be the optimal index for predicting the prognosis of patients with acute PQ poisoning. Additionally, dose of poison, arterial blood lactate, Csec and rebound rate also have referential significance.

  8. Building and validating a prediction model for paediatric type 1 diabetes risk using next generation targeted sequencing of class II HLA genes.

    Science.gov (United States)

    Zhao, Lue Ping; Carlsson, Annelie; Larsson, Helena Elding; Forsander, Gun; Ivarsson, Sten A; Kockum, Ingrid; Ludvigsson, Johnny; Marcus, Claude; Persson, Martina; Samuelsson, Ulf; Örtqvist, Eva; Pyo, Chul-Woo; Bolouri, Hamid; Zhao, Michael; Nelson, Wyatt C; Geraghty, Daniel E; Lernmark, Åke

    2017-11-01

    It is of interest to predict possible lifetime risk of type 1 diabetes (T1D) in young children for recruiting high-risk subjects into longitudinal studies of effective prevention strategies. Utilizing a case-control study in Sweden, we applied a recently developed next generation targeted sequencing technology to genotype class II genes and applied an object-oriented regression to build and validate a prediction model for T1D. In the training set, estimated risk scores were significantly different between patients and controls (P = 8.12 × 10 -92 ), and the area under the curve (AUC) from the receiver operating characteristic (ROC) analysis was 0.917. Using the validation data set, we validated the result with AUC of 0.886. Combining both training and validation data resulted in a predictive model with AUC of 0.903. Further, we performed a "biological validation" by correlating risk scores with 6 islet autoantibodies, and found that the risk score was significantly correlated with IA-2A (Z-score = 3.628, P < 0.001). When applying this prediction model to the Swedish population, where the lifetime T1D risk ranges from 0.5% to 2%, we anticipate identifying approximately 20 000 high-risk subjects after testing all newborns, and this calculation would identify approximately 80% of all patients expected to develop T1D in their lifetime. Through both empirical and biological validation, we have established a prediction model for estimating lifetime T1D risk, using class II HLA. This prediction model should prove useful for future investigations to identify high-risk subjects for prevention research in high-risk populations. Copyright © 2017 John Wiley & Sons, Ltd.

  9. A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery

    Science.gov (United States)

    Jiang, Wu; Lu, Shi-Xun; Lu, Zhen-Hai; Li, Pei-Xing; Yun, Jing-Ping; Zhang, Rong-Xin; Pan, Zhi-Zhong; Wan, De-Sen

    2016-01-01

    Nearly 20% patients with stage II A colon cancer will develop recurrent disease post-operatively. The present study aims to develop a scoring system based on Artificial Neural Network (ANN) model for predicting 10-year survival outcome. The clinical and molecular data of 117 stage II A colon cancer patients from Sun Yat-sen University Cancer Center were used for training set and test set; poor pathological grading (score 49), reduced expression of TGFBR2 (score 33), over-expression of TGF-β (score 45), MAPK (score 32), pin1 (score 100), β-catenin in tumor tissue (score 50) and reduced expression of TGF-β in normal mucosa (score 22) were selected as the prognostic risk predictors. According to the developed scoring system, the patients were divided into 3 subgroups, which were supposed with higher, moderate and lower risk levels. As a result, for the 3 subgroups, the 10-year overall survival (OS) rates were 16.7%, 62.9% and 100% (P < 0.001); and the 10-year disease free survival (DFS) rates were 16.7%, 61.8% and 98.8% (P < 0.001) respectively. It showed that this scoring system for stage II A colon cancer could help to predict long-term survival and screen out high-risk individuals for more vigorous treatment. PMID:27008710

  10. A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery.

    Science.gov (United States)

    Peng, Jian-Hong; Fang, Yu-Jing; Li, Cai-Xia; Ou, Qing-Jian; Jiang, Wu; Lu, Shi-Xun; Lu, Zhen-Hai; Li, Pei-Xing; Yun, Jing-Ping; Zhang, Rong-Xin; Pan, Zhi-Zhong; Wan, De Sen

    2016-04-19

    Nearly 20% patients with stage II A colon cancer will develop recurrent disease post-operatively. The present study aims to develop a scoring system based on Artificial Neural Network (ANN) model for predicting 10-year survival outcome. The clinical and molecular data of 117 stage II A colon cancer patients from Sun Yat-sen University Cancer Center were used for training set and test set; poor pathological grading (score 49), reduced expression of TGFBR2 (score 33), over-expression of TGF-β (score 45), MAPK (score 32), pin1 (score 100), β-catenin in tumor tissue (score 50) and reduced expression of TGF-β in normal mucosa (score 22) were selected as the prognostic risk predictors. According to the developed scoring system, the patients were divided into 3 subgroups, which were supposed with higher, moderate and lower risk levels. As a result, for the 3 subgroups, the 10-year overall survival (OS) rates were 16.7%, 62.9% and 100% (P < 0.001); and the 10-year disease free survival (DFS) rates were 16.7%, 61.8% and 98.8% (P < 0.001) respectively. It showed that this scoring system for stage II A colon cancer could help to predict long-term survival and screen out high-risk individuals for more vigorous treatment.

  11. Does the KABC-II Display Ethnic Bias in the Prediction of Reading, Math, and Writing in Elementary School Through High School?

    Science.gov (United States)

    Scheiber, Caroline

    2017-09-01

    This study explored whether the Kaufman Assessment Battery for Children-Second Edition (KABC-II) predicted academic achievement outcomes of the Kaufman Test of Educational Achievement-Second Edition (KTEA-II) equally well across a representative sample of African American, Hispanic, and Caucasian school-aged children ( N = 2,001) in three grade groups (1-4, 5-8, 9-12). It was of interest to study possible prediction bias in the slope and intercept of the five underlying Cattell-Horn-Carroll (CHC) cognitive factors of the KABC-II-Sequential/Gsm (Short-Term Memory), Learning/Glr (Long-Term Storage and Retrieval), Simultaneous/Gv (Visual Processing), Planning/Gf (Fluid Reasoning), and Knowledge/Gc (Crystallized Ability)-in estimating reading, writing, and math. Structural equation modeling techniques demonstrated a lack of bias in the slopes; however, four of the five CHC indexes showed a persistent overprediction of the minority groups' achievement in the intercept. The overprediction is likely attributable to institutional or societal contributions, which limit the students' ability to achieve to their fullest potential.

  12. Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation

    International Nuclear Information System (INIS)

    Bae, Hyun-Mi; Lee, Jeong-Hoon; Yoon, Jung-Hwan; Kim, Yoon Jun; Heo, Dae Seog; Lee, Hyo-Suk

    2011-01-01

    Clinicians often experience extrahepatic metastases associated with hepatocellular carcinoma (HCC), even if no evidence of intrahepatic recurrence after treatment is observed. We investigated the pretreatment predictors of extrahepatic metastases in HCC patients. Patients diagnosed with HCC without evidence of extrahepatic metastases were prospectively enrolled. We evaluated the correlation between extrahepatic metastases and pretreatment clinical variables, including serum tumor markers. A total of 354 patients were included. Seventy-six patients (21%) had extrahepatic metastases during the observation period (median, 25.3 months; range, 0.6-51.3 months). Cox regression multivariate analysis showed that serum protein induced by vitamin K absence or antagonist-II (PIVKA-II) production levels, the intrahepatic tumor stage, platelet count, and portal vein thrombosis were independent risk factors for extrahepatic metastases. Patients with a PIVKA-II production ≥ 300 mAU/mL had a 2.7-fold (95% confidence interval; 1.5-4.8; P < 0.001) and 3.7-fold (95% confidence interval; 2.0-6.6; P < 0.001) increased risk for extrahepatic metastases after adjustment for stage, platelet count, alpha-fetoprotein ≥ 400 ng/mL, and portal vein thrombosis according to the AJCC and BCLC staging systems, respectively. PIVKA-II production levels might be a good candidate predictive marker for extrahepatic HCC metastases, especially in patients with smaller and/or fewer tumors in the liver with in stages regardless of serum alpha-fetoprotein

  13. ANGDelMut – a web-based tool for predicting and analyzing functional loss mechanisms of amyotrophic lateral sclerosis-associated angiogenin mutations [v2; ref status: indexed, http://f1000r.es/2mc

    Directory of Open Access Journals (Sweden)

    Aditya K Padhi

    2013-12-01

    Full Text Available ANGDelMut is a web-based tool for predicting the functional consequences of missense mutations in the angiogenin (ANG protein, which is associated with amyotrophic lateral sclerosis (ALS. Missense mutations in ANG result in loss of either ribonucleolytic activity or nuclear translocation activity or both of these functions, and in turn cause ALS. However, no web-based tools are available to predict whether a newly identified ANG mutation will possibly lead to ALS. More importantly, no web-implemented method is currently available to predict the mechanisms of loss-of-function(s of ANG mutants. In light of this observation, we developed the ANGDelMut web-based tool, which predicts whether an ANG mutation is deleterious or benign. The user selects certain attributes from the input panel, which serves as a query to infer whether a mutant will exhibit loss of ribonucleolytic activity or nuclear translocation activity or whether the overall stability will be affected. The output states whether the mutation is deleterious or benign, and if it is deleterious, gives the possible mechanism(s of loss-of-function. This web-based tool, freely available at http://bioschool.iitd.ernet.in/DelMut/, is the first of its kind to provide a platform for researchers and clinicians, to infer the functional consequences of ANG mutations and correlate their possible association with ALS ahead of experimental findings.

  14. ANGDelMut – a web-based tool for predicting and analyzing functional loss mechanisms of amyotrophic lateral sclerosis-associated angiogenin mutations [v3; ref status: indexed, http://f1000r.es/2yt

    Directory of Open Access Journals (Sweden)

    Aditya K Padhi

    2014-02-01

    Full Text Available ANGDelMut is a web-based tool for predicting the functional consequences of missense mutations in the angiogenin (ANG protein, which is associated with amyotrophic lateral sclerosis (ALS. Missense mutations in ANG result in loss of either ribonucleolytic activity or nuclear translocation activity or both of these functions, and in turn cause ALS. However, no web-based tools are available to predict whether a newly identified ANG mutation will possibly lead to ALS. More importantly, no web-implemented method is currently available to predict the mechanisms of loss-of-function(s of ANG mutants. In light of this observation, we developed the ANGDelMut web-based tool, which predicts whether an ANG mutation is deleterious or benign. The user selects certain attributes from the input panel, which serves as a query to infer whether a mutant will exhibit loss of ribonucleolytic activity or nuclear translocation activity or whether the overall stability will be affected. The output states whether the mutation is deleterious or benign, and if it is deleterious, gives the possible mechanism(s of loss-of-function. This web-based tool, freely available at http://bioschool.iitd.ernet.in/DelMut/, is the first of its kind to provide a platform for researchers and clinicians, to infer the functional consequences of ANG mutations and correlate their possible association with ALS ahead of experimental findings.

  15. Correlating data from different sensors to increase the positive predictive value of alarms: an empiric assessment [v1; ref status: indexed, http://f1000r.es/RKkXdB

    Directory of Open Access Journals (Sweden)

    Yuval Bitan

    2012-11-01

    Full Text Available Objectives: Alarm fatigue from high false alarm rate is a well described phenomenon in the intensive care unit (ICU. Progress to further reduce false alarms must employ a new strategy. Highly sensitive alarms invariably have a very high false alarm rate. Clinically useful alarms have a high Positive-Predictive Value. Our goal is to demonstrate one approach to suppressing false alarms using an algorithm that correlates information across sensors and replicates the ways that human evaluators discriminate artifact from real signal. Methods: After obtaining IRB approval and waiver of informed consent, a set of definitions, (hypovolemia, left ventricular shock, tamponade, hemodynamically significant ventricular tachycardia, and hemodynamically significant supraventricular tachycardia, were installed in the monitors in a 10 bed cardiothoracic ICU and evaluated over an 85 day study period. The logic of the algorithms was intended to replicate the logic of practitioners, and correlated information across sensors in a way similar to that used by practitioners. The performance of the alarms was evaluated via a daily interview with the ICU attending and review of the tracings recorded over the previous 24 hours in the monitor. True alarms and false alarms were identified by an expert clinician, and the performance of the algorithms evaluated using the standard definitions of sensitivity, specificity, positive predictive value, and negative predictive value. Results: Between 1 and 221 instances of defined events occurred over the duration of the study, and the positive predictive value of the definitions varied between 4.1% and 84%. Conclusions: Correlation of information across alarms can suppress artifact, increase the positive predictive value of alarms, and can employ more sophisticated definitions of alarm events than present single-sensor based systems.

  16. Predicting germination in semi-arid wildland seedbeds II. Field validation of wet thermal-time models

    Science.gov (United States)

    Jennifer K. Rawlins; Bruce A. Roundy; Dennis Eggett; Nathan. Cline

    2011-01-01

    Accurate prediction of germination for species used for semi-arid land revegetation would support selection of plant materials for specific climatic conditions and sites. Wet thermal-time models predict germination time by summing progress toward germination subpopulation percentages as a function of temperature across intermittent wet periods or within singular wet...

  17. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lund, Ole

    2009-01-01

    this binding event. RESULTS: Here, we present a novel artificial neural network-based method, NN-align that allows for simultaneous identification of the MHC class II binding core and binding affinity. NN-align is trained using a novel training algorithm that allows for correction of bias in the training data...

  18. Using Pop-II models to predict effects of wolf predation and hunter harvests on elk, mule deer, and moose on the northern range

    Science.gov (United States)

    Mack, John A.; Singer, Francis J.

    1993-01-01

    The effects of establishing a gray wolf (Canis lupus) population in Yellowstone National Park were predicted for three ungulate species—elk (Cervus elaphus), mule deer (Odocoileus hemionus), and moose (Alces alces)—using previously developed POP-II population models. We developed models for 78 and 100 wolves. For each wolf population, we ran scenarios using wolf predation rates of 9, 12, and 15 ungulates/wolf/year. With 78 wolves and the antlerless elk harvest reduced 27%, our modeled elk population estimated were 5-18% smaller than the model estimate without wolves. With 100 wolves and the antlerless elk harvest reduced 27%, our elk population estimated were 11-30% smaller than the population estimates without wolves. Wolf predation effects were greater on the modeled mule deer population than on elk. With 78 wolves and no antlerless deer harvest, we predicted the mule deer population could be 13-44% larger than without wolves. With 100 wolves and no antlerless deer harvest, the mule deer population was 0-36% larger than without wolves. After wolf recovery, our POP-II models suggested moose harvests would have to be reduced at least 50% to maintain moose numbers at the levels predicted when wolves were not present. Mule deer and moose population data are limited, and these wolf predation effects may be overestimated if population sizes or male-female ratios were underestimated in our population models. We recommend additional mule deer and moose population data be obtained.

  19. Valor preditivo da expressão dos anticorpos Antifator VIII no carcinoma epidermóide do esôfago Predictive value of antifactor VIII antibody expression in squamous cell carcinoma of the esophagus

    Directory of Open Access Journals (Sweden)

    Sebastião Gonzaga Barbosa-Neto

    2007-12-01

    Full Text Available RACIONAL: O carcinoma epidermóide do esôfago apresenta alta mortalidade, baixo índice de diagnóstico precoce e altos custos nos tratamentos, com resultados freqüentemente desapontadores e prognóstico sombrio. O melhor entendimento das técnicas de biologia molecular com citofotometria de imagem, permitiu avançar no conhecimento das alterações na expressão das proteínas desse câncer. OBJETIVOS: Quantificar a expressão das proteínas envolvidas na angiogênese e correlacioná-las com variáveis clínico-patológicas. MÉTODOS: Com o uso da técnica de imunoistoquímica, citofotometria de imagem pelo sistema SAMBA, foram analisadas 29 amostras de carcinoma epidermóide do esôfago incluídas em blocos de parafina. Critérios clínicos como idade, sexo e histopatológicos do grau de diferenciação tumoral, tamanho e localização do tumor foram analisados. Os parâmetros analisados foram o índice de marcagem e a densidade óptica. O marcador utilizado foi o anticorpo anti-Fator VIII. RESULTADOS: Foi possível verificar que as expressões médias do marcador no índice de marcagem foram maiores que as da densidade óptica. Fator VIII apresentou leituras homogêneas. O índice de marcagem foi de 80,17+/-10,40 com P=0,073 e a densidade óptica 51,25+/-11,02 com P=0,245. CONCLUSÃO: A análise quantificação da expressão das proteínas envolvidas na angiogênese permite definir subgrupos de acordo com a diferenciação do carcinoma, estágio tumoral, tamanho e localização do tumor, porém não associa-se com o sexo e a idade dos pacientes, e a densidade óptica do Fator VIII não tem expressão significativa em nenhum dos subgrupos analisados.BACKGROUND: Squamous cell carcinoma of the esophagus exhibits high mortality rate, rare precocious diagnosis, and expensive treatments, presenting frequently disappointed results and poor prognosis. The better understanding about Molecular Biology techniques using cytophotometric imaging allowed

  20. Prediction of near-term increases in suicidal ideation in recently depressed patients with bipolar II disorder using intensive longitudinal data.

    Science.gov (United States)

    Depp, Colin A; Thompson, Wesley K; Frank, Ellen; Swartz, Holly A

    2017-01-15

    There are substantial gaps in understanding near-term precursors of suicidal ideation in bipolar II disorder. We evaluated whether repeated patient-reported mood and energy ratings predicted subsequent near-term increases in suicide ideation. Secondary data were used from 86 depressed adults with bipolar II disorder enrolled in one of 3 clinical trials evaluating Interpersonal and Social Rhythm Therapy and/or pharmacotherapy as treatments for depression. Twenty weeks of daily mood and energy ratings and weekly Hamilton Depression Rating Scale (HDRS) were obtained. Penalized regression was used to model trajectories of daily mood and energy ratings in the 3 week window prior to HDRS Suicide Item ratings. Participants completed an average of 68.6 (sd=52) days of mood and energy ratings. Aggregated across the sample, 22% of the 1675 HDRS Suicide Item ratings were non-zero, indicating presence of at least some suicidal thoughts. A cross-validated model with longitudinal ratings of energy and depressed mood within the three weeks prior to HDRS ratings resulted in an AUC of 0.91 for HDRS Suicide item >2, accounting for twice the variation when compared to baseline HDRS ratings. Energy, both at low and high levels, was an earlier predictor than mood. Data derived from a heterogeneous treated sample may not generalize to naturalistic samples. Identified suicidal behavior was absent from the sample so it could not be predicted. Prediction models coupled with intensively gathered longitudinal data may shed light on the dynamic course of near-term risk factors for suicidal ideation in bipolar II disorder. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Major histocompatibility complex class II compatibility, but not class I, predicts mate choice in a bird with highly developed olfaction.

    Science.gov (United States)

    Strandh, Maria; Westerdahl, Helena; Pontarp, Mikael; Canbäck, Björn; Dubois, Marie-Pierre; Miquel, Christian; Taberlet, Pierre; Bonadonna, Francesco

    2012-11-07

    Mate choice for major histocompatibility complex (MHC) compatibility has been found in several taxa, although rarely in birds. MHC is a crucial component in adaptive immunity and by choosing an MHC-dissimilar partner, heterozygosity and potentially broad pathogen resistance is maximized in the offspring. The MHC genotype influences odour cues and preferences in mammals and fish and hence olfactory-based mate choice can occur. We tested whether blue petrels, Halobaena caerulea, choose partners based on MHC compatibility. This bird is long-lived, monogamous and can discriminate between individual odours using olfaction, which makes it exceptionally well suited for this analysis. We screened MHC class I and II B alleles in blue petrels using 454-pyrosequencing and quantified the phylogenetic, functional and allele-sharing similarity between individuals. Partners were functionally more dissimilar at the MHC class II B loci than expected from random mating (p = 0.033), whereas there was no such difference at the MHC class I loci. Phylogenetic and non-sequence-based MHC allele-sharing measures detected no MHC dissimilarity between partners for either MHC class I or II B. Our study provides evidence of mate choice for MHC compatibility in a bird with a high dependency on odour cues, suggesting that MHC odour-mediated mate choice occurs in birds.

  2. (18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.

    Science.gov (United States)

    Guo, Jinxia; Guo, Ning; Lang, Lixin; Kiesewetter, Dale O; Xie, Qingguo; Li, Quanzheng; Eden, Henry S; Niu, Gang; Chen, Xiaoyuan

    2014-01-01

    or (18)F-FDG were observed, both (18)F-alfatide II Bp and (18)F-FDG influx from kinetic analysis in tumors showed significant decreases. For therapy of MDA-MB-435 tumors with paclitaxel protein-bound particles, a significant decrease was observed only with (18)F-alfatide II Bp value from kinetic analysis but not (18)F-FDG influx. The parameters fitted with compartmental modeling from the dual-tracer dynamic imaging are consistent with those from single-tracer imaging, substantiating the feasibility of this methodology. Even though no significant differences in tumor size were found until 5 d after doxorubicin treatment started, at day 3 there were already substantial differences in (18)F-alfatide II Bp and (18)F-FDG influx rate. Dual-tracer imaging can measure (18)F-alfatide II Bp value and (18)F-FDG influx simultaneously to evaluate tumor angiogenesis and metabolism. Such changes are known to precede anatomic changes, and thus parametric imaging may offer the promise of early prediction of therapy response.

  3. DFT predictions, synthesis, stoichiometric structures and anti-diabetic activity of Cu (II) and Fe (III) complexes of quercetin, morin, and primuletin

    Science.gov (United States)

    Jabeen, Erum; Janjua, Naveed Kausar; Ahmed, Safeer; Murtaza, Iram; Ali, Tahir; Masood, Nosheen; Rizvi, Aysha Sarfraz; Murtaza, Gulam

    2017-12-01

    The current study is aimed at the synthesis of Cu (II) and Fe (III) complexes of three flavonoids {morin (mor), quercetin (quer) and primuletin (prim)} and characterization through UV-Vis spectroscopy, cyclic voltammetry, FTIR, and thermal analysis. Structure prediction through DFT calculation was supported by experimental data. Benesi-Hildebrand equation was modified to function for 1:2 Cu-flavonoid and 1:3 Fe-flavonoid complexes. DFT predictions revealed that out of poly chelation sites present in morin and quercetin, 3-OH site was utilized as preferable chelation site while primuletin chelated through 5-OH position. In-vivo trials revealed the complexes to have better anti-diabetic potential than respective flavonoid. Fls/M-Fls proved as antagonistic to Alloxan induced diabetes and also retained anti-diabetic activity even in the presence of (2-hydroxypropyl)-β-cyclodextrin (HPβCD).

  4. El duelo es un trabajo

    OpenAIRE

    Mesa, Clara Cecilia

    2012-01-01

    Esta pregunta por lo nuevo en la atención en duelo invita a pensar en varias direcciones: qué hay de nuevo como oferta médica para ayudar a soportar la situación de pérdida que el duelo arrastra consigo, por un lado, pero por otro, qué hay de nuevo en el duelo? Es difícil saber si las condiciones de elaboración del duelo se modifican con las particularidades de una época o con las particularidades propias de cada modalidad de sufrimiento, igualmente existe una tesis que afirma que nuestra épo...

  5. Predicting the mixed-mode I/II spatial damage propagation along 3D-printed soft interfacial layer via a hyperelastic softening model

    Science.gov (United States)

    Liu, Lei; Li, Yaning

    2018-07-01

    A methodology was developed to use a hyperelastic softening model to predict the constitutive behavior and the spatial damage propagation of nonlinear materials with damage-induced softening under mixed-mode loading. A user subroutine (ABAQUS/VUMAT) was developed for numerical implementation of the model. 3D-printed wavy soft rubbery interfacial layer was used as a material system to verify and validate the methodology. The Arruda - Boyce hyperelastic model is incorporated with the softening model to capture the nonlinear pre-and post- damage behavior of the interfacial layer under mixed Mode I/II loads. To characterize model parameters of the 3D-printed rubbery interfacial layer, a series of scarf-joint specimens were designed, which enabled systematic variation of stress triaxiality via a single geometric parameter, the slant angle. It was found that the important model parameter m is exponentially related to the stress triaxiality. Compact tension specimens of the sinusoidal wavy interfacial layer with different waviness were designed and fabricated via multi-material 3D printing. Finite element (FE) simulations were conducted to predict the spatial damage propagation of the material within the wavy interfacial layer. Compact tension experiments were performed to verify the model prediction. The results show that the model developed is able to accurately predict the damage propagation of the 3D-printed rubbery interfacial layer under complicated stress-state without pre-defined failure criteria.

  6. Mortality in severe trauma patients attended by emergency services in Navarre, Spain: validation of a new prediction model and comparison with the Revised Injury Severity Classification Score II.

    Science.gov (United States)

    Ali Ali, Bismil; Lefering, Rolf; Fortún Moral, Mariano; Belzunegui Otano, Tomás

    2018-01-01

    To validate the Mortality Prediction Model of Navarre (MPMN) to predict death after severe trauma and compare it to the Revised Injury Severity Classification Score II (RISCII). Retrospective analysis of a cohort of severe trauma patients (New Injury Severity Score >15) who were attended by emergency services in the Spanish autonomous community of Navarre between 2013 and 2015. The outcome variable was 30-day all-cause mortality. Risk was calculated with the MPMN and the RISCII. The performance of each model was assessed with the area under the receiver operating characteristic (ROC) curve and precision with respect to observed mortality. Calibration was assessed with the Hosmer-Lemeshow test. We included 516 patients. The mean (SD) age was 56 (23) years, and 363 (70%) were males. Ninety patients (17.4%) died within 30 days. The 30-day mortality rates predicted by the MPMN and RISCII were 16.4% and 15.4%, respectively. The areas under the ROC curves were 0.925 (95% CI, 0.902-0.952) for the MPMN and 0.941 (95% CI, 0.921-0.962) for the RISCII (P=0.269, DeLong test). Calibration statistics were 13.6 (P=.09) for the MPMN and 8.9 (P=.35) for the RISCII. Both the MPMN and the RISCII show good ability to discriminate risk and predict 30-day all-cause mortality in severe trauma patients.

  7. A systematic review of the factors associated with interest in predictive genetic testing for obesity, type II diabetes and heart disease.

    Science.gov (United States)

    Collins, J; Ryan, L; Truby, H

    2014-10-01

    In the future, it may be possible for individuals to take a genetic test to determine their genetic predisposition towards developing lifestyle-related chronic diseases. A systematic review of the literature was undertaken to identify the factors associated with an interest in having predictive genetic testing for obesity, type II diabetes and heart disease amongst unaffected adults. Ovid Medline, PsycINFO and EMBASE online databases were searched using predefined search terms. Publications meeting the inclusion criteria (English language, free-living adult population not selected as a result of their disease diagnosis, reporting interest as an outcome, not related to a single gene inherited disease) were assessed for quality and content. Narrative synthesis of the results was undertaken. From the 2329 publications retrieved, eight studies met the inclusion criteria and were included in the review. Overall, the evidence base was small but of positive quality. Interest was associated with personal attitudes towards disease risk and the provision of information about genetic testing, shaped by perceived risk of disease and expected outcomes of testing. The role of demographic factors was investigated with largely inconclusive findings. Interest in predictive genetic testing for obesity, type II diabetes or heart disease was greatest amongst those who perceived the risk of disease to be high and/or the outcomes of testing to be beneficial. © 2013 The British Dietetic Association Ltd.

  8. PECITIS-II, a computer program to predict the performance of collapsible clad UO2 fuel elements

    International Nuclear Information System (INIS)

    Anand, A.K.; Anantharaman, K.; Sarda, V.

    1978-01-01

    The Indian power programme envisages the use of PHWRs, which use collapsible clad UO 2 fuel elements. A computer code, PECITIS-II, developed for the analysis of this type of fuel is described in detail. The sheath strain and fission gas pressure are evaluated by this method. The pellet clad gap conductance is calculated by Ross and Solute model. The pellet thermal expansion is calculated by assuming a two zone model, i.e. a plastic core surrounded by an elastic cracked annulus. (author)

  9. El duelo es un trabajo

    Directory of Open Access Journals (Sweden)

    Clara Cecilia Mesa

    2001-02-01

    Full Text Available Esta pregunta por lo nuevo en la atención en duelo invita a pensar en varias direcciones: qué hay de nuevo como oferta médica para ayudar a soportar la situación de pérdida que el duelo arrastra consigo, por un lado, pero por otro, qué hay de nuevo en el duelo? Es difícil saber si las condiciones de elaboración del duelo se modifican con las particularidades de una época o con las particularidades propias de cada modalidad de sufrimiento, igualmente existe una tesis que afirma que nuestra época no es ya la época de la muerte romántica más bien que la condición de guerra haría a su vez que las
    coordenadas del duelo podrían pensarse de manera distinta, sin embargo detrás de lo nuevo siempre encontramos lo viejo: la muerte. Parafraseando el último verso de “Las Flores del Mal” de Baudelaire:

  10. Predictive modeling of infrared radiative heating in tomato dry-peeling process: Part II. Model validation and sensitivity analysis

    Science.gov (United States)

    A predictive mathematical model was developed to simulate heat transfer in a tomato undergoing double sided infrared (IR) heating in a dry-peeling process. The aims of this study were to validate the developed model using experimental data and to investigate different engineering parameters that mos...

  11. Natural(es) remisión de V. ciencias natural(es).

    OpenAIRE

    2011-01-01

    [ES] Definición del término Natural(es) remisión de V. ciencias natural(es). en el diccionario Dicter. [EN] Definition of the word Natural(es) remisión de V. ciencias natural(es). in the dictionary Dicter.

  12. Exchange-Hole Dipole Dispersion Model for Accurate Energy Ranking in Molecular Crystal Structure Prediction II: Nonplanar Molecules.

    Science.gov (United States)

    Whittleton, Sarah R; Otero-de-la-Roza, A; Johnson, Erin R

    2017-11-14

    The crystal structure prediction (CSP) of a given compound from its molecular diagram is a fundamental challenge in computational chemistry with implications in relevant technological fields. A key component of CSP is the method to calculate the lattice energy of a crystal, which allows the ranking of candidate structures. This work is the second part of our investigation to assess the potential of the exchange-hole dipole moment (XDM) dispersion model for crystal structure prediction. In this article, we study the relatively large, nonplanar, mostly flexible molecules in the first five blind tests held by the Cambridge Crystallographic Data Centre. Four of the seven experimental structures are predicted as the energy minimum, and thermal effects are demonstrated to have a large impact on the ranking of at least another compound. As in the first part of this series, delocalization error affects the results for a single crystal (compound X), in this case by detrimentally overstabilizing the π-conjugated conformation of the monomer. Overall, B86bPBE-XDM correctly predicts 16 of the 21 compounds in the five blind tests, a result similar to the one obtained using the best CSP method available to date (dispersion-corrected PW91 by Neumann et al.). Perhaps more importantly, the systems for which B86bPBE-XDM fails to predict the experimental structure as the energy minimum are mostly the same as with Neumann's method, which suggests that similar difficulties (absence of vibrational free energy corrections, delocalization error,...) are not limited to B86bPBE-XDM but affect GGA-based DFT-methods in general. Our work confirms B86bPBE-XDM as an excellent option for crystal energy ranking in CSP and offers a guide to identify crystals (organic salts, conjugated flexible systems) where difficulties may appear.

  13. Comparing the Suitability of Autodock, Gold and Glide for the Docking and Predicting the Possible Targets of Ru(II-Based Complexes as Anticancer Agents

    Directory of Open Access Journals (Sweden)

    Adebayo A. Adeniyi

    2013-03-01

    Full Text Available In cancer chemotherapy, metal-based complexes have been recognized as the most promising means of inhibiting cancer growth due to the successful application of cis-platin and its derivatives above many of the existing organic anticancer agents. The limitations in their rational design can be traced to the complexity of the mechanism of their operations, lack of proper knowledge of their targets and lack of force fields in docking packages to appropriately define the metal centre of the organometallic complexes. In this paper, some of the promising anticancer complexes of Ru(II such as the rapta-based complexes formulated as [Ru(η6-p-cymeneL2(pta] and those with unusual ligands are considered. CatB and kinases which have been experimentally confirmed as possible targets of the complexes are also predicted by the three methods as one of the most targeted receptors while TopII and HDAC7 are predicted by two and one of the methods as best targets. The interesting features of the binding of the complexes show that some of the complexes preferentially target specific macromolecules than the others, which is an indication of their specificity and possibility of their therapeutic combination without severe side effects that may come from competition for the same target. Also, introduction of unusual ligands is found to significantly improve the activities of most of the complexes studied. Strong correlations are observed for the predicted binding sites and the orientation of the complexes within the binding site by the three methods of docking. However there are disparities in the ranking of the complexes by the three method of docking, especially that of Glide.

  14. PREDICTING Lyα AND Mg II FLUXES FROM K AND M DWARFS USING GALAXY EVOLUTION EXPLORER ULTRAVIOLET PHOTOMETRY

    International Nuclear Information System (INIS)

    Shkolnik, Evgenya L.; Rolph, Kristina A.; Peacock, Sarah; Barman, Travis S.

    2014-01-01

    A star's ultraviolet (UV) emission can greatly affect the atmospheric chemistry and physical properties of closely orbiting planets with the potential for severe mass loss. In particular, the Lyα emission line at 1216 Å, which dominates the far-ultraviolet (FUV) spectrum, is a major source of photodissociation of important atmospheric molecules such as water and methane. The intrinsic flux of Lyα, however, cannot be directly measured due to the absorption of neutral hydrogen in the interstellar medium and contamination by geocoronal emission. To date, reconstruction of the intrinsic Lyα line based on Hubble Space Telescope spectra has been accomplished for 46 FGKM nearby stars, 28 of which have also been observed by the Galaxy Evolution Explorer (GALEX). Our investigation provides a correlation between published intrinsic Lyα and GALEX far- and near-ultraviolet (NUV) chromospheric fluxes for K and M stars. The negative correlations between the ratio of the Lyα to the GALEX fluxes reveal how the relative strength of Lyα compared to the broadband fluxes weakens as the FUV and NUV excess flux increase. We also correlate GALEX fluxes with the strong NUV Mg II h+k spectral emission lines formed at lower chromospheric temperatures than Lyα. The reported correlations provide estimates of intrinsic Lyα and Mg II fluxes for the thousands of K and M stars in the archived GALEX all-sky surveys. These will constrain new stellar upper atmosphere models for cool stars and provide realistic inputs to models describing exoplanetary photochemistry and atmospheric evolution in the absence of UV spectroscopy

  15. In Situ Vitrification Engineering-Scale Test ES-INEL-4, ES-INEL-5, ES-INEL-6, and ES-INEL-7 Test Plan

    International Nuclear Information System (INIS)

    Weidner, J.R.; Stoots, P.R.

    1990-10-01

    The In Situ Vitrification Engineering-Scale Tests ES-4, ES-5, ES-6, and ES-7 Product Characterization Test Plan describes the methods and procedures to be used or the physical and chemical characterization of the solid product(s) resulting from the Idaho National Engineering Laboratory engineering scale in situ vitrification tests ES-4, ES-5, ES-6, and ES-7. The goals of this Test Plan are to insure that the product characterization results are sufficient to meet the data needs of the In Situ Vitrification Program and are technically and legally defensible. Important issues addressed by the test plan include sampling and analysis strategy, sampling procedures, laboratory analysis, sample control and document management, equipment, data reporting and validation, quality assurance, specific routine procedures to assess data representativeness, safety and training program, and data management. 9 refs., 1 fig., 3 tabs

  16. Religions mondialisées.

    Directory of Open Access Journals (Sweden)

    Sébastien Fath

    2002-05-01

    Full Text Available « Dès le début de l’histoire, les croyances religieuses manifestent une tendance à ne pas se renfermer dans une société politique étroitement délimitée : il y a en elles comme une aptitude naturelle à passer par-dessus les frontières, à se diffuser, à s’internationaliser ». Ces réflexions d’Émile Durkheim, extraites des Formes élémentaires de la vie religieuse , sont placées en exergue de l’ouvrage d’Ariel Colonomos consacré aux « Églises en réseau ». ...

  17. stockées Ephestia kuehniella (Lepidoptera)

    African Journals Online (AJOL)

    PR BOKO

    de Rebat (2008). [5] - B. DOUMANDJI-MITICHI. Etude d'un ravageur des denrées stockées E. Kuehiella, Am.El Harrach. (1997). [6] - F. TAIBI. Etude comparée du développement et de la reproduction chez deux ravageurs des denrées stockées Ephestia Kuehniella et Tenebrio molitor. Aspect endocrinien en rapport avec.

  18. Confocal arthroscopy-based patient-specific constitutive models of cartilaginous tissues - II: prediction of reaction force history of meniscal cartilage specimens.

    Science.gov (United States)

    Taylor, Zeike A; Kirk, Thomas B; Miller, Karol

    2007-10-01

    The theoretical framework developed in a companion paper (Part I) is used to derive estimates of mechanical response of two meniscal cartilage specimens. The previously developed framework consisted of a constitutive model capable of incorporating confocal image-derived tissue microstructural data. In the present paper (Part II) fibre and matrix constitutive parameters are first estimated from mechanical testing of a batch of specimens similar to, but independent from those under consideration. Image analysis techniques which allow estimation of tissue microstructural parameters form confocal images are presented. The constitutive model and image-derived structural parameters are then used to predict the reaction force history of the two meniscal specimens subjected to partially confined compression. The predictions are made on the basis of the specimens' individual structural condition as assessed by confocal microscopy and involve no tuning of material parameters. Although the model does not reproduce all features of the experimental curves, as an unfitted estimate of mechanical response the prediction is quite accurate. In light of the obtained results it is judged that more general non-invasive estimation of tissue mechanical properties is possible using the developed framework.

  19. Geopressure and Trap Integrity Predictions from 3-D Seismic Data: Case Study of the Greater Ughelli Depobelt, Niger Delta Pressions de pores et prévisions de l’intégrité des couvertures à partir de données sismiques 3D : le cas du grand sous-bassin d’Ughelli, Delta du Niger

    Directory of Open Access Journals (Sweden)

    Opara A.I.

    2012-05-01

    Full Text Available The deep drilling campaign in the Niger Delta has demonstrated the need for a detailed geopressure and trap integrity (drilling margin analysis as an integral and required step in prospect appraisal. Pre-drill pore pressure prediction from 3-D seismic data was carried out in the Greater Ughelli depobelt, Niger Delta basin to predict subsurface pressure regimes and further applied in the determination of hydrocarbon column height, reservoir continuity, fault seal and trap integrity. Results revealed that geopressured sedimentary formations are common within the more prolific deeper hydrocarbon reserves in the Niger Delta basin. The depth to top of mild geopressure (0.60 psi/ft ranges from about 10 000 ftss to over 30 000 ftss. The distribution of geopressures shows a well defined trend with depth to top of geopressures increasing towards the central part of the basin. This variation in the depth of top of geopressures in the area is believed to be related to faulting and shale diapirism, with top of geopressures becoming shallow with shale diapirism and deep with sedimentation. Post-depositional faulting is believed to have controlled the configuration of the geopressure surface and has played later roles in modifying the present day depth to top of geopressures. In general, geopressure in this area is often associated with simple rollover structures bounded by growth faults, especially at the hanging walls, while hydrostatic pressures were observed in areas with k-faults and collapsed crested structures. Les campagnes de forages profonds dans le delta du Niger ont démontré la nécessité d’une analyse détaillée des surpressions et de l’intégrité des structures pour évaluer correctement les prospects. La prédiction des pressions interstitielles a pu être réalisée ici avant forage à partir de données sismiques 3-D du grand sous-bassin d’Ughelli, dans le delta du Niger. Ce travail a permis de prévoir les régimes de pression du

  20. An Assessment of CFD/CSD Prediction State-of-the-Art by Using the HART II International Workshop Data

    Science.gov (United States)

    Smith, Marilyn J.; Lim, Joon W.; vanderWall, Berend G.; Baeder, James D.; Biedron, Robert T.; Boyd, D. Douglas, Jr.; Jayaraman, Buvana; Jung, Sung N.; Min, Byung-Young

    2012-01-01

    Over the past decade, there have been significant advancements in the accuracy of rotor aeroelastic simulations with the application of computational fluid dynamics methods coupled with computational structural dynamics codes (CFD/CSD). The HART II International Workshop database, which includes descent operating conditions with strong blade-vortex interactions (BVI), provides a unique opportunity to assess the ability of CFD/CSD to capture these physics. In addition to a baseline case with BVI, two additional cases with 3/rev higher harmonic blade root pitch control (HHC) are available for comparison. The collaboration during the workshop permits assessment of structured, unstructured, and hybrid overset CFD/CSD methods from across the globe on the dynamics, aerodynamics, and wake structure. Evaluation of the plethora of CFD/CSD methods indicate that the most important numerical variables associated with most accurately capturing BVI are a two-equation or detached eddy simulation (DES)-based turbulence model and a sufficiently small time step. An appropriate trade-off between grid fidelity and spatial accuracy schemes also appears to be pertinent for capturing BVI on the advancing rotor disk. Overall, the CFD/CSD methods generally fall within the same accuracy; cost-effective hybrid Navier-Stokes/Lagrangian wake methods provide accuracies within 50% the full CFD/CSD methods for most parameters of interest, except for those highly influenced by torsion. The importance of modeling the fuselage is observed, and other computational requirements are discussed.

  1. ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients

    Science.gov (United States)

    Vargas, Teodoro; Moreno-Rubio, Juan; Herranz, Jesús; Cejas, Paloma; Molina, Susana; González-Vallinas, Margarita; Mendiola, Marta; Burgos, Emilio; Aguayo, Cristina; Custodio, Ana B.; Machado, Isidro; Ramos, David; Gironella, Meritxell; Espinosa-Salinas, Isabel; Ramos, Ricardo; Martín-Hernández, Roberto; Risueño, Alberto; De Las Rivas, Javier; Reglero, Guillermo; Yaya, Ricardo; Fernández-Martos, Carlos; Aparicio, Jorge; Maurel, Joan; Feliu, Jaime; de Molina, Ana Ramírez

    2015-01-01

    Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolism-related genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to accurately stratify stage II colon cancer patients with 5-fold higher risk of relapse with strong statistical power in the four independent groups of patients. The identification of a group of 4 genes that predict survival in intermediate-stage colon cancer patients allows delineation of a high-risk group that may benefit from adjuvant therapy, and avoids the toxic and unnecessary chemotherapy in patients classified as low-risk group. PMID:25749516

  2. Evaluation of proposed shallow-land burial sites using the PRESTO-II [Prediction of Radiation Effects from Shallow Trench Operations] methodology and code

    International Nuclear Information System (INIS)

    Fields, D.E.; Uslu, I.; Yalcintas, M.G.

    1987-01-01

    PRESTO-II (Prediction of Radiation Effects from Shallow Trench Operations) is a computer code designed to evaluate possible doses and risks (health effects) from shallow-land burial sites. The model is intended to serve as a non-site-specific screening model for assessing radionuclide transport, ensuing exposure, and health impacts to a static local population for a 1000-year period following the end of disposal operations. Human exposure scenarios include normal releases (including leaching and operational spillage), human intrusion, and limited site farming or reclamation. Pathways and processes of transport from the trench to an individual or population include ground-water transport, overland flow, erosion, surface water dilution, suspension, atmospheric transport and deposition, inhalation, external exposure, and ingestion of contaminated beef, milk, crops, and water. The proposed waste disposal area in Koteyli, Balikesir, Turkey, has been evaluated using the PRESTO-II methodology. The results have been compared to those obtained for the Barnwell, South Carolina, site. Dose estimates for both sites are below regulatory limits, for the release and exposure scenarios considered. The doses for the sites are comparable, with slightly higher estimates obtained for the Turkish site. 7 refs., 1 tab

  3. TBscore II

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Lemvik, Grethe; Abate, Ebba

    2013-01-01

    Abstract Background: The TBscore, based on simple signs and symptoms, was introduced to predict unsuccessful outcome in tuberculosis patients on treatment. A recent inter-observer variation study showed profound variation in some variables. Further, some variables depend on a physician assessing...... them, making the score less applicable. The aim of the present study was to simplify the TBscore. Methods: Inter-observer variation assessment and exploratory factor analysis were combined to develop a simplified score, the TBscore II. To validate TBscore II we assessed the association between start...

  4. Identification of PPARgamma partial agonists of natural origin (II: in silico prediction in natural extracts with known antidiabetic activity.

    Directory of Open Access Journals (Sweden)

    Laura Guasch

    Full Text Available BACKGROUND: Natural extracts have played an important role in the prevention and treatment of diseases and are important sources for drug discovery. However, to be effectively used in these processes, natural extracts must be characterized through the identification of their active compounds and their modes of action. METHODOLOGY/PRINCIPAL FINDINGS: From an initial set of 29,779 natural products that are annotated with their natural source and using a previously developed virtual screening procedure (carefully validated experimentally, we have predicted as potential peroxisome proliferators-activated receptor gamma (PPARγ partial agonists 12 molecules from 11 extracts known to have antidiabetic activity. Six of these molecules are similar to molecules with described antidiabetic activity but whose mechanism of action is unknown. Therefore, it is plausible that these 12 molecules could be the bioactive molecules responsible, at least in part, for the antidiabetic activity of the extracts containing them. In addition, we have also identified as potential PPARγ partial agonists 10 molecules from 16 plants with undescribed antidiabetic activity but that are related (i.e., they are from the same genus to plants with known antidiabetic properties. None of the 22 molecules that we predict as PPARγ partial agonists show chemical similarity with a group of 211 known PPARγ partial agonists obtained from the literature. CONCLUSIONS/SIGNIFICANCE: Our results provide a new hypothesis about the active molecules of natural extracts with antidiabetic properties and their mode of action. We also suggest plants with undescribed antidiabetic activity that may contain PPARγ partial agonists. These plants represent a new source of potential antidiabetic extracts. Consequently, our work opens the door to the discovery of new antidiabetic extracts and molecules that can be of use, for instance, in the design of new antidiabetic drugs or functional foods focused

  5. Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II: in silico prediction in antidiabetic extracts.

    Directory of Open Access Journals (Sweden)

    Laura Guasch

    Full Text Available BACKGROUND: Natural extracts play an important role in traditional medicines for the treatment of diabetes mellitus and are also an essential resource for new drug discovery. Dipeptidyl peptidase IV (DPP-IV inhibitors are potential candidates for the treatment of type 2 diabetes mellitus, and the effectiveness of certain antidiabetic extracts of natural origin could be, at least partially, explained by the inhibition of DPP-IV. METHODOLOGY/PRINCIPAL FINDINGS: Using an initial set of 29,779 natural products that are annotated with their natural source and an experimentally validated virtual screening procedure previously developed in our lab (Guasch et al.; 2012 [1], we have predicted 12 potential DPP-IV inhibitors from 12 different plant extracts that are known to have antidiabetic activity. Seven of these molecules are identical or similar to molecules with described antidiabetic activity (although their role as DPP-IV inhibitors has not been suggested as an explanation for their bioactivity. Therefore, it is plausible that these 12 molecules could be responsible, at least in part, for the antidiabetic activity of these extracts through their inhibitory effect on DPP-IV. In addition, we also identified as potential DPP-IV inhibitors 6 molecules from 6 different plants with no described antidiabetic activity but that share the same genus as plants with known antidiabetic properties. Moreover, none of the 18 molecules that we predicted as DPP-IV inhibitors exhibits chemical similarity with a group of 2,342 known DPP-IV inhibitors. CONCLUSIONS/SIGNIFICANCE: Our study identified 18 potential DPP-IV inhibitors in 18 different plant extracts (12 of these plants have known antidiabetic properties, whereas, for the remaining 6, antidiabetic activity has been reported for other plant species from the same genus. Moreover, none of the 18 molecules exhibits chemical similarity with a large group of known DPP-IV inhibitors.

  6. Immunogenicity and prediction of epitopic region of antigen Ag I/II and glucosyltransferase from Streptococcus mutans.

    Science.gov (United States)

    Cao, Xi-Xi; Fan, Jian; Chen, Jiang; Li, Yu-Hong; Fan, Ming-Wen

    2016-06-01

    The levels of Streptococcus (S.) mutans infections in saliva were evaluated and a comparison for specific antibody levels among children with different levels of S. mutans infection was made. The promising epitopic regions of antigen AgI/II (PAc) and glucosyltransferase (GTF) for potential vaccine targets related to S. mutans adherence were screened. A total of 94 children aged 3-4 years were randomly selected, including 53 caries-negative and 41 caries-positive children. The values of S. mutans and those of salivary total secretory immunoglobulin A (sIgA), anti-PAc and anti-Glucan binding domain (anti-GLU) were compared to determine the correlation among them. It was found the level of s-IgA against specific antigens did not increase with increasing severity of S. mutans infection, and the complete amino acid sequence of PAc and GTFB was analyzed using the DNAStar Protean system for developing specific anti-caries vaccines related to S. mutans adherence. A significantly positive correlation between the amount of S. mutans and children decayed, missing, and filled teeth index was observed. No significant difference was detected in specific sIgA against PAc or GLU between any two groups. No significant correlation was found between such specific sIgA and caries index. A total of 16 peptides from PAc as well as 13 peptides from GTFB were chosen for further investigation. S. mutans colonization contributed to early children caries as an important etiological factor. The level of sIgA against specific antigens did not increase with increasing severity of S. mutans infection in children. The epitopes of PAc and GTF have been screened to develop the peptide-based or protein-based anti-caries vaccines.

  7. Pensées intimes

    CERN Document Server

    Einstein, Albert

    2000-01-01

    A quelqu'un qui lui demandant pourquoi les hommes pouvaient découvrir les atomes, mais pas les moyens de les contrôler, Einstein répondit : " C'est simple, mon ami : parce que la politique est plus difficile que la physique ". Albert Einstein était un écrivain prolifique dont l'œuvre abonde en aphorismes. Les 550 citations de ce recueil, tirées des quelque 40 000 documents des Archives Einstein, nous font découvrir le Einstein de la légende, l'ami des écoliers et des étudiants fauchés, le philosophe de la vie quotidienne, doux et ironique, mais aussi la face plus sombre, parfois désespérée, de ce grand génie de l'ère moderne. Qu'il s'exprime sur des sujets aussi variés que l'Amérique et les Américains, l'Allemagne et les Allemands, les Juifs et le sionisme, la guerre et le pacifisme, la politique, la religion et la science, ou sur des thèmes plus personnels, tels que l'amour et le mariage, la jeunesse et la vieillesse l'avortement ou l'homosexualité, ses propos restent toujours mordants,...

  8. Climate Change Effects on Agricultural Production of Iran: II. Predicting Productivity of Field Crops and Adaptation Strategies

    Directory of Open Access Journals (Sweden)

    A Koocheki

    2016-07-01

    Full Text Available Introduction Recent evidences confirm that during the next few decades, many agroclimatic indices of Iran would be affected by global climate change. Koocheki et al. using two General Circulation Models showed that the mean annual temperature of the country will increase between 3.5-4.5°C while mean precipitation will reduce by 7-15% to 2050. It is well established that crop growth and development would drastically affect by the future global warming and its consequences because yield determining processes such as photosynthesis and crop phenology are directly related to temperature. On the other hands, the combined effects of CO2 enrichment and temperature rise on crop growth are complicated and should be studied using crop simulation models. Furthermore, adapting to climatic variability will have a substantially greater effect in reducing impacts than willing mitigation. However, such impacts on crop productivity at national scale and adaptive measures for future conditions are rarely studied in Iran. In this research crop development and yield of wheat, corn, chickpea and sugar beet were simulated for the target year of 2050 and the results are compared with the current yield as the baseline. Materials and Methods Future climatic variables were predicted using A1f (business as usual scenario by GFDL general circulation model and the results were used as weather inputs in the SUCROS model which was previously validated against measured data of the four crops. To account for the effect of CO2 enrichment on crop growth the photosynthesis routine of the model was adopted for increased CO2 concentration using a scaling factor. Changes in developmental stages of each crop were estimated for the future conditions and the relation between duration of these stages and yield was determined. Predicted crop yields for the year 2050 were compared with the current potential yields considering some adaptation strategies. Results and Discussion Results

  9. Development of a web-based liver cancer prediction model for type II diabetes patients by using an artificial neural network.

    Science.gov (United States)

    Rau, Hsiao-Hsien; Hsu, Chien-Yeh; Lin, Yu-An; Atique, Suleman; Fuad, Anis; Wei, Li-Ming; Hsu, Ming-Huei

    2016-03-01

    Diabetes mellitus is associated with an increased risk of liver cancer, and these two diseases are among the most common and important causes of morbidity and mortality in Taiwan. To use data mining techniques to develop a model for predicting the development of liver cancer within 6 years of diagnosis with type II diabetes. Data were obtained from the National Health Insurance Research Database (NHIRD) of Taiwan, which covers approximately 22 million people. In this study, we selected patients who were newly diagnosed with type II diabetes during the 2000-2003 periods, with no prior cancer diagnosis. We then used encrypted personal ID to perform data linkage with the cancer registry database to identify whether these patients were diagnosed with liver cancer. Finally, we identified 2060 cases and assigned them to a case group (patients diagnosed with liver cancer after diabetes) and a control group (patients with diabetes but no liver cancer). The risk factors were identified from the literature review and physicians' suggestion, then, chi-square test was conducted on each independent variable (or potential risk factor) for a comparison between patients with liver cancer and those without, those found to be significant were selected as the factors. We subsequently performed data training and testing to construct artificial neural network (ANN) and logistic regression (LR) prediction models. The dataset was randomly divided into 2 groups: a training group and a test group. The training group consisted of 1442 cases (70% of the entire dataset), and the prediction model was developed on the basis of the training group. The remaining 30% (618 cases) were assigned to the test group for model validation. The following 10 variables were used to develop the ANN and LR models: sex, age, alcoholic cirrhosis, nonalcoholic cirrhosis, alcoholic hepatitis, viral hepatitis, other types of chronic hepatitis, alcoholic fatty liver disease, other types of fatty liver disease, and

  10. Can Early Computed Tomography Angiography after Endovascular Aortic Aneurysm Repair Predict the Need for Reintervention in Patients with Type II Endoleak?

    Energy Technology Data Exchange (ETDEWEB)

    Dudeck, O., E-mail: oliver.dudeck@med.ovgu.de [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany); Schnapauff, D. [Charité Universitätsmedizin Berlin, Department of Radiology (Germany); Herzog, L.; Löwenthal, D.; Bulla, K.; Bulla, B. [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany); Halloul, Z.; Meyer, F. [University of Magdeburg, Department of General, Visceral and Vascular Surgery (Germany); Pech, M. [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany); Gebauer, B. [Charité Universitätsmedizin Berlin, Department of Radiology (Germany); Ricke, J. [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany)

    2015-02-15

    PurposeThis study was designed to identify parameters on CT angiography (CTA) of type II endoleaks following endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA), which can be used to predict the subsequent need for reinterventions.MethodsWe retrospectively identified 62 patients with type II endoleak who underwent early CTA in mean 3.7 ± 1.9 days after EVAR. On the basis of follow-up examinations (mean follow-up period 911 days; range, 373–1,987 days), patients were stratified into two groups: those who did (n = 18) and those who did not (n = 44) require reintervention. CTA characteristics, such as AAA, endoleak, as well as nidus dimensions, patency of the inferior mesenteric artery, number of aortic branch vessels, and the pattern of endoleak appearance, were recorded and correlated with the clinical outcome.ResultsUnivariate and receiver operating characteristic curve regression analyses revealed significant differences between the two groups for the endoleak volume (surveillance group: 1391.6 ± 1427.9 mm{sup 3}; reintervention group: 3227.7 ± 2693.8 mm{sup 3}; cutoff value of 2,386 mm{sup 3}; p = 0.002), the endoleak diameter (13.6 ± 4.3 mm compared with 25.9 ± 9.6 mm; cutoff value of 19 mm; p < 0.0001), the number of aortic branch vessels (2.9 ± 1.2 compared with 4.2 ± 1.4 vessels; p = 0.001), as well as a “complex type” endoleak pattern (13.6 %, n = 6 compared with 44.4 %, n = 8; p = 0.02).ConclusionsEarly CTA can predict the future need for reintervention in patients with type II endoleak. Therefore, treatment decision should be based not only on aneurysm enlargement alone but also on other imaging characteristics.

  11. Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Yoshinori Ino

    Full Text Available An adequate level of arginine in the tissue microenvironment is essential for T cell activity and survival. Arginine levels are regulated by the arginine-catabolizing enzyme, arginase (ARG. It has been reported that arginase II (ARG2, one of two ARGs, is aberrantly expressed in prostate cancer cells, which convert arginine into ornithine, resulting in a lack of arginine that weakens tumor-infiltrating lymphocytes and renders them dysfunctional. However, immune suppression mediated by ARG2-expressing cancer cells in lung cancer has not been observed. Here we studied the expression of ARG2 in pancreatic ductal carcinoma (PDC tissue clinicopathologically by examining over 200 cases of PDC. In contrast to prostate cancer, ARG2 expression was rarely demonstrated in PDC cells by immunohistochemistry, and instead ARG2 was characteristically expressed in α-smooth muscle actin-positive cancer-associated fibroblasts (CAFs, especially those located within and around necrotic areas in PDC. The presence of ARG2-expressing CAFs was closely correlated with shorter overall survival (OS; P  = 0.003 and disease-free survival (DFS; P  = 0.0006. Multivariate Cox regression analysis showed that the presence of ARG2-expressing CAFs in PDC tissue was an independent predictor of poorer OS (hazard ratio [HR]  = 1.582, P  = 0.007 and DFS (HR  = 1.715, P  = 0.001 in PDC patients. In addition to the characteristic distribution of ARG2-expressing CAFs, such CAFs co-expressed carbonic anhydrase IX, SLC2A1, or HIF-1α, markers of hypoxia, in PDC tissue. Furthermore, in vitro experiments revealed that cultured fibroblasts extracted from PDC tissue expressed the ARG2 transcript after exposure to hypoxia, which had arginase activity. These results indicate that cancer cell-mediated immune suppression through ARG2 expression is not a general event and that the presence of ARG2-expressing CAFs is an indicator of poor prognosis, as well as hypoxia, in PDC

  12. Mathematical formulation to predict the harmonics of the superconducting Large Hadron Collider magnets. II. Dynamic field changes and scaling laws

    Directory of Open Access Journals (Sweden)

    Nicholas J. Sammut

    2007-08-01

    Full Text Available A superconducting particle accelerator like the LHC (Large Hadron Collider at CERN, can only be controlled well if the effects of the magnetic field multipoles on the beam are compensated. The demands on a control system solely based on beam feedback may be too high for the requirements to be reached at the specified bandwidth and accuracy. Therefore, we designed a suitable field description for the LHC (FIDEL as part of the machine control baseline to act as a feed-forward magnetic field prediction system. FIDEL consists of a physical and empirical parametric field model based on magnetic measurements at warm and in cryogenic conditions. The performance of FIDEL is particularly critical at injection when the field decays, and in the initial part of the acceleration when the field snaps back. These dynamic components are both current and time dependent and are not reproducible from cycle to cycle since they also depend on the magnet powering history. In this paper a qualitative and quantitative description of the dynamic field behavior substantiated by a set of scaling laws is presented.

  13. MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans

    Science.gov (United States)

    Acevedo-Whitehouse, Karina; Gulland, Frances; Bowen, Lizabeth

    2018-01-01

    We examined the associations between California sea lion MHC class II DRB (Zaca-DRB) configuration and diversity, and leptospirosis. As Zaca-DRB gene sequences are involved with antigen presentation of bacteria and other extracellular pathogens, we predicted that they would play a role in determining responses to these pathogenic spirochaetes. Specifically, we investigated whether Zaca-DRB diversity (number of genes) and configuration (presence of specific genes) explained differences in disease severity, and whether higher levels of Zaca-DRB diversity predicted the number of specific Leptospira interrogans serovars that a sea lion's serum would react against. We found that serum from diseased sea lions with more Zaca-DRB loci reacted against a wider array of serovars. Specific Zaca-DRB loci were linked to reactions with particular serovars. Interestingly, sea lions with clinical manifestation of leptospirosis that had higher numbers of Zaca-DRB loci were less likely to recover from disease than those with lower diversity, and those that harboured Zaca-DRB.C or –G were 4.5 to 5.3 times more likely to die from leptospirosis, regardless of the infective serovars. We propose that for leptospirosis, a disadvantage of having a wider range of antigen presentation might be increased disease severity due to immunopathology. Ours is the first study to examine the importance of Zaca-DRB diversity for antigen detection and disease severity following natural exposure to infective leptospires.

  14. LUNAR OUTGASSING, TRANSIENT PHENOMENA, AND THE RETURN TO THE MOON. II. PREDICTIONS AND TESTS FOR OUTGASSING/REGOLITH INTERACTIONS

    International Nuclear Information System (INIS)

    Crotts, Arlin P. S.; Hummels, Cameron

    2009-01-01

    We follow Paper I with predictions of how gas leaking through the lunar surface could influence the regolith, as might be observed via optical transient lunar phenomena (TLPs) and related effects. We touch on several processes, but concentrate on low and high flow rate extremes, which are perhaps the most likely. We model explosive outgassing for the smallest gas overpressure at the regolith base that releases the regolith plug above it. This disturbance's timescale and affected area are consistent with observed TLPs; we also discuss other effects. For slow flow, escape through the regolith is prolonged by low diffusivity. Water, found recently in deep magma samples, is unique among candidate volatiles, capable of freezing between the regolith base and surface, especially near the lunar poles. For major outgassing sites, we consider the possible accumulation of water ice. Over geological time, ice accumulation can evolve downward through the regolith. Depending on gases additional to water, regolith diffusivity might be suppressed chemically, blocking seepage and forcing the ice zone to expand to larger areas, up to km 2 scales, again, particularly at high latitudes. We propose an empirical path forward, wherein current and forthcoming technologies provide controlled, sensitive probes of outgassing. The optical transient/outgassing connection, addressed via Earth-based remote sensing, suggests imaging and/or spectroscopy, but aspects of lunar outgassing might be more covert, as indicated above. TLPs betray some outgassing, but does outgassing necessarily produce TLPs? We also suggest more intrusive techniques from radar to in situ probes. Understanding lunar volatiles seems promising in terms of resource exploitation for human exploration of the Moon and beyond, and offers interesting scientific goals in its own right. Many of these approaches should be practiced in a pristine lunar atmosphere, before significant confusing signals likely to be produced upon humans

  15. Tomo II

    OpenAIRE

    Llano Zapata, José Eusebio

    2015-01-01

    Memorias, histórico, físicas, crítico, apologéticas de la América Meridional con unas breves advertencias y noticias útiles, a los que de orden de Su Majestad hubiesen de viajar y describir aquellas vastas regiones. Reino Vegetal, Tomo II. Por un anónimo americano en Cádiz por los años de 1757. Muy Señor mío, juzgo que los 20 artículos del libro que remití a Vuestra Merced le habrán hecho formar el concepto que merece la fecundidad de aquellos países en las producciones minerales. Y siendo es...

  16. Bringing colour back after 70 years: Predicting eye and hair colour from skeletal remains of World War II victims using the HIrisPlex system.

    Science.gov (United States)

    Chaitanya, Lakshmi; Pajnič, Irena Zupanič; Walsh, Susan; Balažic, Jože; Zupanc, Tomaž; Kayser, Manfred

    2017-01-01

    Retrieving information about externally visible characteristics from DNA can provide investigative leads to find unknown perpetrators, and can also help in disaster victim and other missing person identification cases. Aiming for the application to both types of forensic casework, we previously developed and forensically validated the HIrisPlex test system enabling parallel DNA prediction of eye and hair colour. Although a recent proof-of-principle study demonstrated the general suitability of the HIrisPlex system for successfully analysing DNA from bones and teeth of various storage times and conditions, practical case applications to human remains are scarce. In this study, we applied the HIrisPlex system to 49 DNA samples obtained from bones or teeth of World War II victims excavated at six sites, mostly mass graves, in Slovenia. PCR-based DNA quantification ranged from 4pg/μl to 313pg/μl and on an average was 41pg/μl across all samples. All 49 samples generated complete HIrisPlex profiles with the exception of one MC1R DNA marker (N29insA) missing in 83.7% of the samples. In 44 of the 49 samples (89.8%) complete 15-loci autosomal STR (plus amelogenin) profiles were obtained. Of 5 pairs of skeletal remains for which STR profiling suggested an origin in the same individuals, respectively, 4 showed the same HIrisPlex profiles and predicted eye and hair colours, respectively, while discrepancies in one pair (sample 26 and 43) are likely to be explained by DNA quantity and quality issues observed in sample 43. Sample 43 had the lowest DNA concentration of only 4pg/μl, producing least reliable STR results and could be misleading in concluding that samples 43 and 26 originate from the same individual. The HIrisPlex-predicted eye and hair colours from two skeletal samples, suggested to derive from two brothers via STR profiling together with a living sister, were confirmed by the living sister's report. Overall, we demonstrate that after more than 70 years, HIris

  17. El mundo es un paisaje sonoro

    OpenAIRE

    Rezza, Sol

    2009-01-01

    El sonido es movimiento, sin movimiento no hay sonido. Nuestras vidas cotidianas están plagadas de sonidos, el mundo es un mundo sonoro. Soundscape, paisajes sonoros, postales sonoras, ambientes sonoros son algunos de los nombres con los que se define al sonido o a la combinación de sonidos que conforman un entono específico, es decir un ambiente sonoro.

  18. INJEÇÕES PARENTERAIS

    Directory of Open Access Journals (Sweden)

    Wanda Aguiar Horta

    Full Text Available RESUMO São apresentadas considerações gerais sobre injeções parenterals. O estudo, expõe, com particularidade, as vias intramusculares (del-tóide, dorso glútea, ventro-glútea lateral ou Hochstetter e fêmuro-lateral e as vias endovenosa, subcutánea e intradérmica. Sobre cada via o estudo apresenta: definição, condições da droga, seleção do material, indicações, locais com detalhes anatômicos e a técnica da aplicação, incluindo o preparo do paciente e do material e o cuidado com este. Os principais acidentes gerais são descritos e detalhados particularmente em cada via. As tabelas I e II apresentam a indicação dos tipos de agulhas de acordo com as drogas, a idade e a espessura do tecido subcutâneo, além dos locais prioritários para aplicação em adultos e crianças.

  19. Systolic Sac Pressure Index for the Prediction of Persistent Type II Endoleak for 12 Months After Endovascular Abdominal Aortic Aneurysm Repair

    Energy Technology Data Exchange (ETDEWEB)

    Ikoma, Akira, E-mail: yfb04322@nifty.com; Nakai, Motoki, E-mail: momonga@wakayama-med.ac.jp; Sato, Morio, E-mail: morisato@wakayama-med.ac.jp; Sato, Hirotatsu, E-mail: kuppa1220@yahoo.co.jp; Minamiguchi, Hiroki, E-mail: hiromina4@hotmail.com; Sonomura, Tetsuo, E-mail: sonomura@wakayama-med.ac.jp [Wakayama Medical University, Departments of Radiology (Japan); Nishimura, Yoshiharu, E-mail: nishim-y@wakayama-med.ac.jp; Okamura, Yoshitaka, E-mail: y-ok@wakayama-med.ac.jp [Wakayama Medical University, Thoracic and Cardiovascular Surgery (Japan)

    2016-04-15

    PurposeTo assess the relationship between the systolic sac pressure index (SPI) and the presence of endoleaks 12 months after endovascular abdominal aortic aneurysm repair (EVAR).Materials and MethodsWe performed a single-center prospective trial of consecutively treated patients. SPI (calculated as systolic sac pressure/systolic aortic pressure) was measured by catheterization immediately after EVAR. Contrast-enhanced computed tomography was scheduled 12 months after EVAR to detect possible endoleaks.ResultsData were available for 34 patients who underwent EVAR for an AAA. Persisting type II endoleak was found in 8 patients (endoleak-positive group) but not in the other 26 patients (endoleak-negative group). The mean ± standard deviation SPI was significantly greater in the endoleak-positive group than in the endoleak-negative group (0.692 ± 0.048 vs. 0.505 ± 0.081, respectively; P = .001). Receiver-operating characteristic curve analysis revealed that an SPI of 0.638 was the optimum cutoff value for predicting a persistent endoleak at 12 months with high accuracy (0.971; 33/34), sensitivity (1.00), and specificity (0.962) values. The mean change in AAA diameter was −4.28 ± 5.03 mm and 2.22 ± 4.54 mm in patients with SPI of <0.638 or ≥0.638, respectively (P = .002).ConclusionPatients with an SPI of ≥0.638 immediately after EVAR were more likely to have a persistent type II endoleak at 12 months with an accuracy of 0.971, and showed increases in aneurysm sac diameter compared with patients with an SPI of <0.638.

  20. Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation.

    Science.gov (United States)

    Michael, G; Dempster, J; Kane, K A; Coker, S J

    2007-12-01

    Torsade de pointes (TdP) can be induced by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether IKs blockade or enhancement of INa could potentiate TdP induced by IKr blockade and to investigate whether short-term variability (STV) or triangulation of action potentials preceded TdP. Experiments were performed in open-chest, pentobarbital-anaesthetized, alpha 1-adrenoceptor-stimulated, male New Zealand White rabbits, which received three consecutive i.v. infusions of either the IKr blocker E-4031 (1, 3 and 10 nmol kg(-1) min(-1)), the IKs blocker HMR1556 (25, 75 and 250 nmol kg(-1) min(-1)) or E-4031 and HMR1556 combined. In a second study rabbits received either the same doses of E-4031, the INa enhancer, ATX-II (0.4, 1.2 and 4.0 nmol kg(-1)) or both of these drugs. ECGs and epicardial monophasic action potentials were recorded. HMR1556 alone did not cause TdP but increased E-4031-induced TdP from 25 to 80%. ATX-II alone caused TdP in 38% of rabbits, as did E-4031; 75% of rabbits receiving both drugs had TdP. QT intervals were prolonged by all drugs but the extent of QT prolongation was not related to the occurrence of TdP. No changes in STV were detected and triangulation was only increased after TdP occurred. Giving modulators of ion channels in combination substantially increased TdP but, in this model, neither STV nor triangulation of action potentials could predict TdP.

  1. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    Department of Chemistry Bayero University, P. M. B. 3011, Kano, Nigeria. E-mail: hnuhu2000@yahoo.com. ABSTRACT. The manganese (II), cobalt (II), nickel (II) and .... water and common organic solvents, but are readily soluble in acetone. The molar conductance measurement [Table 3] of the complex compounds in.

  2. Stable Versus Unstable Grade II High Ankle Sprains: A Prospective Study Predicting the Need for Surgical Stabilization and Time to Return to Sports.

    Science.gov (United States)

    Calder, James D; Bamford, Richard; Petrie, Aviva; McCollum, Graham A

    2016-04-01

    II injuries and may be used to identify which athletes may benefit from early arthroscopic assessment and stabilization. They may also be important in predicting the time frame for athletes' expected return to play. Level II, prospective comparative study. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  3. Assessment of air quality benefits from national air pollution control policies in China. Part II: Evaluation of air quality predictions and air quality benefits assessment

    Science.gov (United States)

    Wang, Litao; Jang, Carey; Zhang, Yang; Wang, Kai; Zhang, Qiang; Streets, David; Fu, Joshua; Lei, Yu; Schreifels, Jeremy; He, Kebin; Hao, Jiming; Lam, Yun-Fat; Lin, Jerry; Meskhidze, Nicholas; Voorhees, Scott; Evarts, Dale; Phillips, Sharon

    2010-09-01

    Following the meteorological evaluation in Part I, this Part II paper presents the statistical evaluation of air quality predictions by the U.S. Environmental Protection Agency (U.S. EPA)'s Community Multi-Scale Air Quality (Models-3/CMAQ) model for the four simulated months in the base year 2005. The surface predictions were evaluated using the Air Pollution Index (API) data published by the China Ministry of Environmental Protection (MEP) for 31 capital cities and daily fine particulate matter (PM 2.5, particles with aerodiameter less than or equal to 2.5 μm) observations of an individual site in Tsinghua University (THU). To overcome the shortage in surface observations, satellite data are used to assess the column predictions including tropospheric nitrogen dioxide (NO 2) column abundance and aerosol optical depth (AOD). The result shows that CMAQ gives reasonably good predictions for the air quality. The air quality improvement that would result from the targeted sulfur dioxide (SO 2) and nitrogen oxides (NO x) emission controls in China were assessed for the objective year 2010. The results show that the emission controls can lead to significant air quality benefits. SO 2 concentrations in highly polluted areas of East China in 2010 are estimated to be decreased by 30-60% compared to the levels in the 2010 Business-As-Usual (BAU) case. The annual PM 2.5 can also decline by 3-15 μg m -3 (4-25%) due to the lower SO 2 and sulfate concentrations. If similar controls are implemented for NO x emissions, NO x concentrations are estimated to decrease by 30-60% as compared with the 2010 BAU scenario. The annual mean PM 2.5 concentrations will also decline by 2-14 μg m -3 (3-12%). In addition, the number of ozone (O 3) non-attainment areas in the northern China is projected to be much lower, with the maximum 1-h average O 3 concentrations in the summer reduced by 8-30 ppb.

  4. Comparison of midlatitude ionospheric F region peak parameters and topside Ne profiles from IRI2012 model prediction with ground-based ionosonde and Alouette II observations

    Science.gov (United States)

    Gordiyenko, G. I.; Yakovets, A. F.

    2017-07-01

    The ionospheric F2 peak parameters recorded by a ground-based ionosonde at the midlatitude station Alma-Ata [43.25N, 76.92E] were compared with those obtained using the latest version of the IRI model (http://omniweb.gsfc.nasa.gov/vitmo/iri2012_vitmo.html). It was found that for the Alma-Ata (Kazakhstan) location, the IRI2012 model describes well the morphology of seasonal and diurnal variations of the ionospheric critical frequency (foF2) and peak density height (hmF2) monthly medians. The model errors in the median foF2 prediction (percentage deviations between the median foF2 values and their model predictions) were found to vary approximately in the range from about -20% to 34% and showed a stable overestimation in the median foF2 values for daytime in January and July and underestimation for day- and nighttime hours in the equinoctial months. The comparison between the ionosonde hmF2 and IRI results clearly showed that the IRI overestimates the nighttime hmF2 values for March and September months, and the difference is up to 30 km. The daytime Alma-Ata hmF2 data were found to be close to the IRI predictions (deviations are approximately ±10-15 km) in winter and equinoctial months, except in July when the observed hmF2 values were much more (from approximately 50-200 km). The comparison between the Alouette foF2 data and IRI predictions showed mixed results. In particular, the Alouette foF2 data showed a tendency to be overestimated for daytime in winter months similar to the ionosonde data; however, the overestimated foF2 values for nighttime in the autumn equinox were in disagreement with the ionosonde observations. There were large deviations between the observed hmF2 values and their model predictions. The largest deviations were found during winter and summer (up to -90 km). The comparison of the Alouette II electron density profiles with those predicted by the adapted IRI2012 model in the altitude range hmF2 of the satellite position showed a great

  5. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

    International Nuclear Information System (INIS)

    Alves, Vinicius M.; Muratov, Eugene; Fourches, Denis; Strickland, Judy; Kleinstreuer, Nicole; Andrade, Carolina H.; Tropsha, Alexander

    2015-01-01

    Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between molecular structure and skin permeability of sensitizers and non-sensitizers. The goals of this study were to: (i) compile, curate, and integrate the largest publicly available dataset of chemicals studied for their skin permeability; (ii) develop and rigorously validate QSAR models to predict skin permeability; and (iii) explore the complex relationships between skin sensitization and skin permeability. Based on the largest publicly available dataset compiled in this study, we found no overall correlation between skin permeability and skin sensitization. In addition, cross-species correlation coefficient between human and rodent permeability data was found to be as low as R 2 = 0.44. Human skin permeability models based on the random forest method have been developed and validated using OECD-compliant QSAR modeling workflow. Their external accuracy was high (Q 2 ext = 0.73 for 63% of external compounds inside the applicability domain). The extended analysis using both experimentally-measured and QSAR-imputed data still confirmed the absence of any overall concordance between skin permeability and skin sensitization. This observation suggests that chemical modifications that affect skin permeability should not be presumed a priori to modulate the sensitization potential of chemicals. The models reported herein as well as those developed in the companion paper on skin sensitization suggest that it may be possible to rationally design compounds with the desired high skin permeability but low sensitization potential. - Highlights: • It was compiled the largest publicly-available skin permeability dataset. • Predictive QSAR models were developed for skin permeability. • No concordance between skin sensitization and

  6. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Vinicius M. [Laboratory of Molecular Modeling and Design, Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO 74605-220 (Brazil); Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States); Muratov, Eugene [Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States); Laboratory of Theoretical Chemistry, A.V. Bogatsky Physical–Chemical Institute NAS of Ukraine, Odessa 65080 (Ukraine); Fourches, Denis [Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States); Strickland, Judy; Kleinstreuer, Nicole [ILS/Contractor supporting the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), P.O. Box 13501, Research Triangle Park, NC 27709 (United States); Andrade, Carolina H. [Laboratory of Molecular Modeling and Design, Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO 74605-220 (Brazil); Tropsha, Alexander, E-mail: alex_tropsha@unc.edu [Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States)

    2015-04-15

    Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between molecular structure and skin permeability of sensitizers and non-sensitizers. The goals of this study were to: (i) compile, curate, and integrate the largest publicly available dataset of chemicals studied for their skin permeability; (ii) develop and rigorously validate QSAR models to predict skin permeability; and (iii) explore the complex relationships between skin sensitization and skin permeability. Based on the largest publicly available dataset compiled in this study, we found no overall correlation between skin permeability and skin sensitization. In addition, cross-species correlation coefficient between human and rodent permeability data was found to be as low as R{sup 2} = 0.44. Human skin permeability models based on the random forest method have been developed and validated using OECD-compliant QSAR modeling workflow. Their external accuracy was high (Q{sup 2}{sub ext} = 0.73 for 63% of external compounds inside the applicability domain). The extended analysis using both experimentally-measured and QSAR-imputed data still confirmed the absence of any overall concordance between skin permeability and skin sensitization. This observation suggests that chemical modifications that affect skin permeability should not be presumed a priori to modulate the sensitization potential of chemicals. The models reported herein as well as those developed in the companion paper on skin sensitization suggest that it may be possible to rationally design compounds with the desired high skin permeability but low sensitization potential. - Highlights: • It was compiled the largest publicly-available skin permeability dataset. • Predictive QSAR models were developed for skin permeability. • No concordance between skin

  7. Predictive role of HER2/neu, topoisomerase-II-alpha, and tissue inhibitor of metalloproteinases (TIMP-1) for response to adjuvant taxane-based chemotherapy in patients with intermediate-risk breast cancer

    DEFF Research Database (Denmark)

    Erber, Ramona; Gluz, Oleg; Brünner, Nils

    2015-01-01

    . In this study, we investigate a large cohort of patients with intermediate-risk BC treated within the WSG EC-DOC Trial for the predictive impact of topoisomerase-II-alpha, HER2/neu, and TIMP-1. Tumor tissue was available in a representative cohort of 772 cases of the WSG EC-DOC Trial collective which compared 4...

  8. Novel Bioinformatics-Based Approach for Proteomic Biomarkers Prediction of Calpain-2 & Caspase-3 Protease Fragmentation: Application to βII-Spectrin Protein

    Science.gov (United States)

    El-Assaad, Atlal; Dawy, Zaher; Nemer, Georges; Kobeissy, Firas

    2017-01-01

    The crucial biological role of proteases has been visible with the development of degradomics discipline involved in the determination of the proteases/substrates resulting in breakdown-products (BDPs) that can be utilized as putative biomarkers associated with different biological-clinical significance. In the field of cancer biology, matrix metalloproteinases (MMPs) have shown to result in MMPs-generated protein BDPs that are indicative of malignant growth in cancer, while in the field of neural injury, calpain-2 and caspase-3 proteases generate BDPs fragments that are indicative of different neural cell death mechanisms in different injury scenarios. Advanced proteomic techniques have shown a remarkable progress in identifying these BDPs experimentally. In this work, we present a bioinformatics-based prediction method that identifies protease-associated BDPs with high precision and efficiency. The method utilizes state-of-the-art sequence matching and alignment algorithms. It starts by locating consensus sequence occurrences and their variants in any set of protein substrates, generating all fragments resulting from cleavage. The complexity exists in space O(mn) as well as in O(Nmn) time, where N, m, and n are the number of protein sequences, length of the consensus sequence, and length per protein sequence, respectively. Finally, the proposed methodology is validated against βII-spectrin protein, a brain injury validated biomarker.

  9. DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer

    DEFF Research Database (Denmark)

    Nygård, Sune Boris; Vainer, Ben; Nielsen, Signe L

    2016-01-01

    FISH and follow-up data were obtained from 534 patients. TOP1 gain was identified in 27 % using a single-probe enumeration strategy (≥ 4 TOP1 signals per cell), and in 31 % when defined by a TOP1/CEN20 ratio ≥ 1.5. The effect of additional irinotecan was not dependent on TOP1 FISH status. TOP1 m......PURPOSE: Prospective-retrospective assessment of the TOP1 gene copy number and TOP1 mRNA expression as predictive biomarkers for adjuvant irinotecan in stage II/III colon cancer (CC). EXPERIMENTAL DESIGN: Formalin-fixed, paraffin-embedded tissue microarrays were obtained from an adjuvant CC trial...... (PETACC3) where patients were randomized to 5-fluorouracil/folinic acid with or without additional irinotecan. TOP1 copy number status was analyzed by fluorescence in situ hybridization (FISH) using a TOP1/CEN20 dual-probe combination. TOP1 mRNA data were available from previous analyses. RESULTS: TOP1...

  10. p53 and Ki-67 in Barrett's carcinoma: is there any value to predict recurrence after circumferential endoscopic mucosal resection? p53 e Ki-67 no carcinoma do esôfago de Barrett: algum valor na predição da recurrência após mucosectomia endoscópica circunferencial?

    Directory of Open Access Journals (Sweden)

    César Vivian Lopes

    2007-12-01

    Full Text Available BACKGROUND: There are situations in which the specimens obtained after endoscopic mucosal resection of superficial adenocarcinoma arising from Barrett's esophagus are not adequate for histopathological assessment of the margins. In these cases, immunohistochemistry might be an useful tool for predicting cancer recurrence. AIM: To evaluate the value of p53 and Ki-67 immunohistochemistry in predicting the cancer recurrence in patients with Barrett's esophagus-related cancer referred to circumferential endoscopic mucosal resection. METHODS: Mucosectomy specimens from 41 patients were analyzed. All endoscopic biopsies prior to endoscopic mucosal resection presented high-grade dysplasia and cancer was detected in 23 of them. Positive reactions were considered the intense coloration in the nuclei of at least 90% of the cells in each high-power magnification field, and immunostaining could be classified as superficial or diffuse according to the mucosal distribution of the stained nuclei. RESULTS: Endoscopic mucosal resection samples detected cancer in 21 cases. In these cases, p53 immunohistochemistry revealed a diffuse positivity for the great majority of these cancers (90.5% vs. 20%, and Ki-67 showed a diffuse pattern for all cases (100% vs. 30%; conversely, patients without cancer revealed a superficial or negative pattern for p53 (80% vs. 9.5% and Ki-67 (70% vs. 0%. During a mean follow-up of 31.6 months, 5 (12.2% patients developed six episodes of recurrent cancer. Endoscopic mucosal resection specimens did not show any significant difference in the p53 and Ki-67 expression for patients developing cancer after endoscopic treatment. CONCLUSIONS: p53 and Ki-67 immunohistochemistry were useful to confirm the cancer; however, they had not value for predicting the recurrent carcinoma after circumferential endoscopic mucosal resection of Barrett's carcinoma.RACIONAL: Há situações nas quais o material obtido após mucosectomia endoscópica do

  11. Star Formation in M 33 (HerM33es)

    Science.gov (United States)

    Kramer, C.; Boquien, M.; Braine, J.; Buchbender, C.; Calzetti, D.; Gratier, P.; Mookerjea, B.; Relaño, M.; Verley, S.

    2011-11-01

    Within the key project "Herschel M 33 extended survey" (HerM33es), we are studying the physical and chemical processes driving star formation and galactic evolution in the nearby galaxy M 33, combining the study of local conditions affecting individual star formation with properties only becoming apparent on global scales. Here, we present recent results obtained by the HerM33es team. Combining Spitzer and Herschel data ranging from 3.6 μm to 500μm, along with H i, Hα, and GALEX UV data, we have studied the dust at high spatial resolutions of 150 pc, providing estimators of the total infrared (TIR) brightness and of the star formation rate. While the temperature of the warm dust at high brightness is driven by young massive stars, evolved stellar populations appear to drive the temperature of the cold dust. Plane-parallel models of photon dominated regions (PDRs) fail to reproduce fully the [C ii], [O i], and CO maps obtained in a first spectroscopic study of one 2' × 2' subregion of M 33, located on the inner, northern spiral arm and encompassing the H ii region BCLMP 302.

  12. UTILIZATION OF 5Es' CONSTRUCTIVIST APPROACH FOR ...

    African Journals Online (AJOL)

    Global Journal

    learning, the effective utilization of which can enhance biology teaching and learning. This paper focused on how ... KEYWORDS: Utilization, 5Es Constructivist approach, difficult concepts, Biology. ... gives hope to the development of the deep.

  13. University of Dar es Salaam Library Journal

    African Journals Online (AJOL)

    University of Dar es Salaam Library Journal. ... PROMOTING ACCESS TO AFRICAN RESEARCH ... These include organization and dissemination of information, library education and training, information technology and its application in ...

  14. Sequence analysis and structure prediction of type II Pseudomonas sp. USM 4–55 PHA synthase and an insight into its catalytic mechanism

    Directory of Open Access Journals (Sweden)

    Ahmad Khairudin Nurul

    2006-11-01

    Full Text Available Abstract Background Polyhydroxyalkanoates (PHA, are biodegradable polyesters derived from many microorganisms such as the pseudomonads. These polyesters are in great demand especially in the packaging industries, the medical line as well as the paint industries. The enzyme responsible in catalyzing the formation of PHA is PHA synthase. Due to the limited structural information, its functional properties including catalysis are lacking. Therefore, this study seeks to investigate the structural properties as well as its catalytic mechanism by predicting the three-dimensional (3D model of the Type II Pseudomonas sp. USM 4–55 PHA synthase 1 (PhaC1P.sp USM 4–55. Results Sequence analysis demonstrated that PhaC1P.sp USM 4–55 lacked similarity with all known structures in databases. PSI-BLAST and HMM Superfamily analyses demonstrated that this enzyme belongs to the alpha/beta hydrolase fold family. Threading approach revealed that the most suitable template to use was the human gastric lipase (PDB ID: 1HLG. The superimposition of the predicted PhaC1P.sp USM 4–55 model with 1HLG covering 86.2% of the backbone atoms showed an RMSD of 1.15 Å. The catalytic residues comprising of Cys296, Asp451 and His479 were found to be conserved and located adjacent to each other. In addition to this, an extension to the catalytic mechanism was also proposed whereby two tetrahedral intermediates were believed to form during the PHA biosynthesis. These transition state intermediates were further postulated to be stabilized by the formation of oxyanion holes. Based on the sequence analysis and the deduced model, Ser297 was postulated to contribute to the formation of the oxyanion hole. Conclusion The 3D model of the core region of PhaC1P.sp USM 4–55 from residue 267 to residue 484 was developed using computational techniques and the locations of the catalytic residues were identified. Results from this study for the first time highlighted Ser297 potentially

  15. Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer

    Directory of Open Access Journals (Sweden)

    Susini T

    2014-11-01

    Full Text Available Tommaso Susini,1 Barbara Berti,1 Carlo Carriero,1 Ketty Tavella,2 Jacopo Nori,3 Ermanno Vanzi,3 Cecilia Molino,1 Mariarosaria Di Tommaso,1 Marco Santini,1 Valeria Saladino,4 Simonetta Bianchi4 1Department of Health Science, Gynecology Section, 2Department of Health Science, Chemotherapy Section, University of Florence, Italy; 3Diagnostic Senology Unit, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; 4Department of Surgery and Translational Medicine, Pathology Unit, University of Florence, Italy Purpose: Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A and transducin-like enhancer of split 3 (TLE3 as predictive markers of response to therapy with anthracyclines and taxanes. Materials and methods: TOP2A and TLE3 protein expressions were evaluated using immunohistochemistry on 28 samples, obtained by core needle biopsy in patients with locally advanced breast carcinoma, subsequently subjected to epirubicin- and paclitaxel-based neoadjuvant chemotherapy. The immunohistochemical staining was correlated with the clinical response measured by the tumor size reduction evaluated by breast magnetic resonance imaging, prior and after chemotherapy, and by pathologic evaluation of the surgical specimen. Results: Neoadjuvant chemotherapy achieved a size reduction in 26/28 tumors (92.9%, with an average percentage decrease of 45.6%. A downstaging was achieved in 71.4% of the cases of locally advanced carcinoma. TOP2A positivity was correlated with a greater reduction in tumor diameter (P=0.06; negative staining for TLE3 was predictive of a better response to neoadjuvant chemotherapy (P=0.07. A higher reduction in tumor diameter (P=0.03 was also found for tumors that were concurrently TLE3-negative and TOP2A

  16. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

    Science.gov (United States)

    Alves, Vinicius M.; Muratov, Eugene; Fourches, Denis; Strickland, Judy; Kleinstreuer, Nicole; Andrade, Carolina H.; Tropsha, Alexander

    2015-01-01

    Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between molecular structure and skin permeability of sensitizers and non-sensitizers. The goals of this study were to: (i) compile, curate, and integrate the largest publicly available dataset of chemicals studied for their skin permeability; (ii) develop and rigorously validate QSAR models to predict skin permeability; and (iii) explore the complex relationships between skin sensitization and skin permeability. Based on the largest publicly available dataset compiled in this study, we found no overall correlation between skin permeability and skin sensitization. In addition, cross-species correlation coefficient between human and rodent permeability data was found to be as low as R2=0.44. Human skin permeability models based on the random forest method have been developed and validated using OECD-compliant QSAR modeling workflow. Their external accuracy was high (Q2ext = 0.73 for 63% of external compounds inside the applicability domain). The extended analysis using both experimentally-measured and QSAR-imputed data still confirmed the absence of any overall concordance between skin permeability and skin sensitization. This observation suggests that chemical modifications that affect skin permeability should not be presumed a priori to modulate the sensitization potential of chemicals. The models reported herein as well as those developed in the companion paper on skin sensitization suggest that it may be possible to rationally design compounds with the desired high skin permeability but low sensitization potential. PMID:25560673

  17. Uso do adesivo de fibrina na anastomose esôfago-esofágica cervical, em cães

    Directory of Open Access Journals (Sweden)

    Orlando Ribeiro Prado Filho

    Full Text Available OBJETIVO: Estudar os efeitos da associação do adesivo cirúrgico de fibrina à técnica operatória da invaginação submucosa, em anastomoses esofagianas. MÉTODO: Trinta e dois cães submetidos à anastomose esôfago-esofágica foram alocados em dois grupos: I com sutura em doze pontos e II com sutura em quatro pontos e vedação com adesivo de fibrina. Os animais foram avaliados no sétimo e décimo-quarto dias de pós-operatório. Foram analisados: a evolução ponderal, o índice de estenose, a incidência de deiscências e fístulas, a presença de secreções na tela subcutânea, a presença de líquido intersticial, matriz protêica, celularidade, fibroblastos, fibras de colágeno e concentração de hidroxiprolina. RESULTADOS: O índice de estenose foi menor para os animais do grupo I no sétimo dia de observação. Nos animais do grupo II a incidência de deiscências, secreção serosa e purulenta foram signitivamente maiores aos sete e quatorze dias, enquanto a presença de fístulas foi maior no sétimo dia. Quanto à concentração tecidual de hidroxiprolina não houve diferença estatística entre os grupos. Os fibroblastos e fibras de colágeno tiveram presença mais acentuada no grupo II no décimo-quarto dia. Ocorreram quatro óbitos em animais do grupo II. CONCLUSÕES: A anastomose por invaginação submucosa-mucosa com vedação com adesivo de fibrina apresentou piores resultados que a anastomose convencional de doze pontos circunferenciais.

  18. The novel EuroSCORE II algorithm predicts the hospital mortality of thoracic aortic surgery in 461 consecutive Japanese patients better than both the original additive and logistic EuroSCORE algorithms.

    Science.gov (United States)

    Nishida, Takahiro; Sonoda, Hiromichi; Oishi, Yasuhisa; Tanoue, Yoshihisa; Nakashima, Atsuhiro; Shiokawa, Yuichi; Tominaga, Ryuji

    2014-04-01

    The European System for Cardiac Operative Risk Evaluation (EuroSCORE) II was developed to improve the overestimation of surgical risk associated with the original (additive and logistic) EuroSCOREs. The purpose of this study was to evaluate the significance of the EuroSCORE II by comparing its performance with that of the original EuroSCOREs in Japanese patients undergoing surgery on the thoracic aorta. We have calculated the predicted mortalities according to the additive EuroSCORE, logistic EuroSCORE and EuroSCORE II algorithms in 461 patients who underwent surgery on the thoracic aorta during a period of 20 years (1993-2013). The actual in-hospital mortality rates in the low- (additive EuroSCORE of 3-6), moderate- (7-11) and high-risk (≥11) groups (followed by overall mortality) were 1.3, 6.2 and 14.4% (7.2% overall), respectively. Among the three different risk groups, the expected mortality rates were 5.5 ± 0.6, 9.1 ± 0.7 and 13.5 ± 0.2% (9.5 ± 0.1% overall) by the additive EuroSCORE algorithm, 5.3 ± 0.1, 16 ± 0.4 and 42.4 ± 1.3% (19.9 ± 0.7% overall) by the logistic EuroSCORE algorithm and 1.6 ± 0.1, 5.2 ± 0.2 and 18.5 ± 1.3% (7.4 ± 0.4% overall) by the EuroSCORE II algorithm, indicating poor prediction (P algorithms were 0.6937, 0.7169 and 0.7697, respectively. Thus, the mortality expected by the EuroSCORE II more closely matched the actual mortality in all three risk groups. In contrast, the mortality expected by the logistic EuroSCORE overestimated the risks in the moderate- (P = 0.0002) and high-risk (P < 0.0001) patient groups. Although all of the original EuroSCOREs and EuroSCORE II appreciably predicted the surgical mortality for thoracic aortic surgery in Japanese patients, the EuroSCORE II best predicted the mortalities in all risk groups.

  19. ¿Es la Internet un derecho?

    Directory of Open Access Journals (Sweden)

    Eduardo Villanueva Mansilla

    2010-09-01

    Full Text Available Internet ha sido declarado como derecho, lo que hace que su acceso, uso y penetración sean considerados como prioritarios en todas las zonas del planeta. La intención de este ensayo es esbozar cuáles serían estos efectos. El derecho al Internet es simplemente la garantía de poder participar de la vida en sociedad sea como ciudadano o como consumidor sin restricción alguna. El acceso al Internet no es simple ni barato, implica un conjunto de acciones que requieren intervención del Estado, de varios actores económicos y del propio ciudadano. Asume el tratamiento de las complejidades de este derecho y el desafío para Latinoamérica.

  20. ULCERA GASTRODUODENAL EM CÃES

    Directory of Open Access Journals (Sweden)

    Francisco Assis Uma Costa

    1993-12-01

    Full Text Available As ulcerações no sistema digestivo de cães são consideradas raras. São descritos dois casos de úlcera gastroduodenal em cães. O primeiro animal apresentou úlcera no duodeno próxima!. O segundo mostrou úlcera perfurada na região pilórica do estômago. Nenhum dos animais apresentou evidências de sangramento, mas as lesões eram profundas e arredondadas. Não houve evidência de patologias concorrentes.

  1. Achieving a predictable 24-hour return to normal activities after breast augmentation: part II. Patient preparation, refined surgical techniques, and instrumentation.

    Science.gov (United States)

    Tebbetts, John B

    2006-12-01

    The goal of this study was to develop practices that would allow patients undergoing subpectoral augmentation to predictably return to full normal activities within 24 hours after the operation, free of postoperative adjuncts. Part I of this study used motion and time study principles to reduce operative times, medication dosages, perioperative morbidity, and recovery times in augmentation mammaplasty. Part II of the study focuses on details of patient education, preoperative planning, instrumentation, and surgical technique modifications that were identified, modified, and implemented to achieve the results reported in part I. Two groups of 16 patients each (groups 1 and 2) were studied retrospectively for comparison to a third group of 627 patients (group 3) studied prospectively. Patients in group 1 had axillary partial retropectoral breast augmentations in 1982-1983, using dissociative anesthesia, blunt instrument implant pocket dissection, and Dow Corning, double-lumen implants containing 20 mg of methylprednisolone and 20 cc of saline in the outer lumen of the implants. Patients in group 2 (1990) had inframammary, retromammary augmentations by using a combination of blunt and electrocautery dissection, Surgitek Replicon polyurethane-covered, silicone gel-filled implants, and general endotracheal anesthesia. Patients in group 3 (1998 to 2001, n = 627) had inframammary partial retropectoral, inframammary retromammary, and axillary partial retropectoral augmentations under general endotracheal anesthesia. Refined practices and surgical techniques from studies of groups 1 and 2 were applied in group 3. Videotapes from operative procedures of groups 1 and 2 were analyzed with macromotion and micromotion study principles, and tables of events were formulated for each move during the operation for all personnel in the operating room. Extensive details of surgical technique were examined and reexamined in 13 different stages by using principles of motion and time

  2. National Centers for Environmental Prediction-Department of Energy (NCEP-DOE) Atmospheric Model Intercomparison Project (AMIP)-II Reanalysis (Reanalysis-2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NCEP-DOE Atmospheric Model Intercomparison Project (AMIP-II) reanalysis is a follow-on project to the "50-year" (1948-present) NCEP-NCAR Reanalysis Project....

  3. NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ

    DEFF Research Database (Denmark)

    Karosiene, Edita; Rasmussen, Michael; Blicher, Thomas

    2013-01-01

    Major histocompatibility complex class II (MHCII) molecules play an important role in cell-mediated immunity. They present specific peptides derived from endosomal proteins for recognition by T helper cells. The identification of peptides that bind to MHCII molecules is therefore of great importa......MHCIIpan-3.0 method is the first pan-specific predictor covering all HLA class II molecules with known sequences including HLA-DR, HLA-DP, and HLA-DQ. The NetMHCpan-3.0 method is available at http://www.cbs.dtu.dk/services/NetMHCIIpan-3.0....

  4. Excreta Disposal in Dar-es-salaam

    NARCIS (Netherlands)

    Chaggu, E.; Mashouri, D.; Buuren, van J.C.L.; Sanders, W.T.M.; Lettinga, G.

    2002-01-01

    The sociocultural and socioeconomic situation of sanitation in Dar-es-Salaam (Dsm), Tanzania, was studied with explicit emphasis on pit-latrines. Without considering the sociocultural conditions, the so-called best solution might not be the right one. Therefore, in order to achieve the intended

  5. El punto de partida es nuestra identidad

    OpenAIRE

    Alcalde, Pamela

    2016-01-01

    Néstor tiene claro que su identidad es algo primordial en su arte, desde los mantos pre incas de la cultura Paracas hasta el indigenismo con José Sabogal. Además, considera necesario tener una proyección social, buscar que la gente se sienta reflejada en sus obras.

  6. Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men

    Directory of Open Access Journals (Sweden)

    Karim Zouaoui Boudjeltia

    2013-01-01

    Full Text Available The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO, an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels.

  7. High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients

    DEFF Research Database (Denmark)

    Nielsen, Boye Schnack; Jørgensen, Stine; Fog, Jacob Ulrik

    2011-01-01

    Approximately 25% of all patients with stage II colorectal cancer will experience recurrent disease and subsequently die within 5 years. MicroRNA-21 (miR-21) is upregulated in several cancer types and has been associated with survival in colon cancer. In the present study we developed a robust...... in situ hybridization assay using high-affinity Locked Nucleic Acid (LNA) probes that specifically detect miR-21 in formalin-fixed paraffin embedded (FFPE) tissue samples. The expression of miR-21 was analyzed by in situ hybridization on 130 stage II colon and 67 stage II rectal cancer specimens. The mi...... relative to the nuclear density (TBR) obtained using a red nuclear stain. High TBR (and TB) estimates of miR-21 expression correlated significantly with shorter disease-free survival (p = 0.004, HR = 1.28, 95% CI: 1.06-1.55) in the stage II colon cancer patient group, whereas no significant correlation...

  8. The expression of chemokine receptors CXCR3 and CXCR4 in predicting postoperative tumour progression in stages I-II colon cancer: a retrospective study.

    Science.gov (United States)

    Du, Changzheng; Yao, Yunfeng; Xue, Weicheng; Zhu, Wei-Guo; Peng, Yifan; Gu, Jin

    2014-01-01

    The prognostic significance of chemokine receptors in stage I/II colon cancer is unclear. We assessed the prognostic value of chemokine receptor CXCR3 and CXCR4 in stage I/II colon cancer. 145 patients with stage I/II colon cancer who underwent curative surgery alone from 2000 to 2007 were investigated. Chemokine receptor expression was assessed by immunohistochemistry. The associations between CXCR3, CXCR4 and clinicopathological variables were analysed using the χ2 test, and the relationships between chemokine receptors and a 5-year disease-free survival were analysed by univariate and multivariate analyses. The high-expression rates of CXCR3 and CXCR4 were 17.9% (26/145) and 38.6% (56/145), respectively. There were no significant associations between the expressions of CXCR3, CXCR4 and clinicopathological factors including gender, age, tumour location, histological differentiation, pathological stage, lymphovascular invasion and pretreatment serum carcinoembryonic antigen (CEA). The 5-year disease-free survival was not significantly different between low-expression groups and high-expression groups of CXCR3 and CXCR4. Multivariate analysis revealed that serum CEA and a number of retrieved lymph nodes, rather than chemokine receptors, were independent prognosticators. CXCR3 and CXCR4 are not independent prognosticators for stage I/II colon cancer after curative surgery.

  9. Predictive Performance of SYNTAX Score II in Patients With Left Main and Multivessel Coronary Artery Disease - Analysis of CREDO-Kyoto Registry

    NARCIS (Netherlands)

    C.A.M. Campos (Carlos); D. van Klaveren (David); A. Iqbal (Anwarul); Y. Onuma (Yoshinobu); Y. Zhang (Ying); H.M. Garcia-Garcia (Hector); M.-A. Morel (Marie-Angel); V. Farooq (Vasim); Shiomi, H; Furukawa, Y; Nakagawa, Y; Kadota, K; P.A. Lemos Neto (Pedro); T. Kimura (Takeshi); E.W. Steyerberg (Ewout); P.W.J.C. Serruys (Patrick)

    2014-01-01

    textabstractBackground: SYNTAX score II (SSII) provides individualized estimates of 4-year mortality after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in order to facilitate decision-making between these revascularization methods. The purpose of the present

  10. Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer

    NARCIS (Netherlands)

    Kandimalla, R.; Linnekamp, J. F.; van Hooff, S.; Castells, A.; Llor, X.; Andreu, M.; Jover, R.; Goel, A.; Medema, J. P.

    2017-01-01

    Stage II colon cancer (CC) still remains a clinical challenge with patient stratification for adjuvant therapy (AT) largely relying on clinical parameters. Prognostic biomarkers are urgently needed for better stratification. Previously, we have shown that WNT target genes AXIN2, DKK1, APCDD1, ASCL2

  11. The Origins of dEs

    Science.gov (United States)

    Skillman, Evan D.

    With the new discoveries that some dEs are rotationally supported and that dIs may show a large variety in star formation histories, the perceived relationships between these two families of galaxies are changing. There are at least three viable channels for the origin of dwarf elliptical galaxies with strong observational evidence that support their reality. I will discuss the observational evidence for each of these channels and the likely physical processes which determine each channel.

  12. ¿Que es TeleSUR?

    Directory of Open Access Journals (Sweden)

    Carlos Arcila Calderón

    2014-12-01

    Full Text Available Telesur nace en el seno de proyecto político, de resistencia contra el orden mundial actual, en el convencimiento de que la comunicación es capaz de lograr metas importantes en los procesos de cohesión de las sociedades. El desafío fue crear un medio de comunicación independiente de las empresas comerciales.

  13. ¿Qué es conducta?

    Directory of Open Access Journals (Sweden)

    Esteve Freixa i Baqué

    2003-01-01

    Full Text Available La definición de la Psicología como ciencia de la conducta adoptada por el Conductismo supone e implica a su vez una conceptualización clara y unívoca de dicho concepto. Pero tal definición se enfrenta con una serie de malentendidos tenaces que dificultan no sólo la comprensión de dicho concepto básico sino también, en consecuencia, la propia conceptualización conductista. El propósito del presente trabajo es intentar exponer algunos de estos malentendidos, entre los que destacan los errores categoriales groseros, los procesos de reificación abusiva, los razonamientos tautológicos disfrazados, la generalización imprudente del modelo médico al ámbito de la conducta y la confusión nefasta entre un fenómeno y su conceptualización. Para ello, y con un tono más didáctico que académico, se recurre a una serie de metáforas de la vida cotidiana: la parte escondida del iceberg no es más que iceberg, las piedras no caen por su propio peso, los hombres y las mujeres no mueren porque son mortales, el bacilo de Koch existe y la máscara no es el rostro.

  14. Investigation of low pressure ES-SAGD

    Energy Technology Data Exchange (ETDEWEB)

    Ivory, J.; Zheng, R.; Nasr, T.; Deng, X.; Beaulieu, G.; Heck, G. [Alberta Research Council, Edmonton, AB (Canada)

    2008-10-15

    This paper described a scaled model experiment conducted to investigate the effectiveness of expanding solvent steam assisted gravity drainage (ES-SAGD) processes at low pressures. Lower SAGD pressures typically result in reduced oil production as a result of correspondingly lower steam temperatures. However, lower pressures may also result in a reduced steam to oil ratio (SOR) and a higher vaporization heat. Steam was injected into an injection well at 33 cm{sup 3} per minute and in a production well at 31 cm{sup 3} per minute. Steam and solvents were then co-injected into the injection well at a temperature of 206 degrees C. The experiment was history-matched and a parametric analysis was conducted using a simulation tool. The 2-D and 3-D field-scale simulations investigated the impact of operating pressures, injection rates; sub-cool; oil and gas phase diffusion and dispersion; live oil versus dead oil performance; and the use of drawdown when oil rates declined. Low pressure ES-SAGD was then compared with low-pressure SAGD. Results of the study suggested that production pressures, sub-cool and solvent concentrations are important parameters in ES-SAGD processes. At 1500 kPa production pressure and 10 degrees C sub-cool, the co-injection of solvent with steam increased average oil rates by 15 per cent more than the SAGD process. SOR was also reduced. 6 refs., 8 tabs., 20 figs.

  15. Towards a chromatographic similarity index to establish localised quantitative structure-retention relationships for retention prediction. II Use of Tanimoto similarity index in ion chromatography.

    Science.gov (United States)

    Park, Soo Hyun; Talebi, Mohammad; Amos, Ruth I J; Tyteca, Eva; Haddad, Paul R; Szucs, Roman; Pohl, Christopher A; Dolan, John W

    2017-11-10

    Quantitative Structure-Retention Relationships (QSRR) are used to predict retention times of compounds based only on their chemical structures encoded by molecular descriptors. The main concern in QSRR modelling is to build models with high predictive power, allowing reliable retention prediction for the unknown compounds across the chromatographic space. With the aim of enhancing the prediction power of the models, in this work, our previously proposed QSRR modelling approach called "federation of local models" is extended in ion chromatography to predict retention times of unknown ions, where a local model for each target ion (unknown) is created using only structurally similar ions from the dataset. A Tanimoto similarity (TS) score was utilised as a measure of structural similarity and training sets were developed by including ions that were similar to the target ion, as defined by a threshold value. The prediction of retention parameters (a- and b-values) in the linear solvent strength (LSS) model in ion chromatography, log k=a - blog[eluent], allows the prediction of retention times under all eluent concentrations. The QSRR models for a- and b-values were developed by a genetic algorithm-partial least squares method using the retention data of inorganic and small organic anions and larger organic cations (molecular mass up to 507) on four Thermo Fisher Scientific columns (AS20, AS19, AS11HC and CS17). The corresponding predicted retention times were calculated by fitting the predicted a- and b-values of the models into the LSS model equation. The predicted retention times were also plotted against the experimental values to evaluate the goodness of fit and the predictive power of the models. The application of a TS threshold of 0.6 was found to successfully produce predictive and reliable QSRR models (Q ext(F2) 2 >0.8 and Mean Absolute Error<0.1), and hence accurate retention time predictions with an average Mean Absolute Error of 0.2min. Crown Copyright

  16. Predictive Ability of the SYNergy Between Percutaneous Coronary Intervention with TAXus and Cardiac Surgery Score II for Long-term Mortality in Patients with Three-vessel Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Treated with Second-generation Drug-eluting Stents

    Directory of Open Access Journals (Sweden)

    Ji-Qiang He

    2015-01-01

    Conclusion: The SS-II is an independent predictor of 5-year mortality in patients with three-vessel CAD undergoing PCI treated with second-generation DES, and demonstrates a superior predictive ability over the SS alone.

  17. Synthesis, characterization and polymerization of methacrylates of copper (II), cobalt (II) and molybdenum (II). Generation of new materials

    International Nuclear Information System (INIS)

    Rojas Bolanos, Omar

    2006-01-01

    Coordination compounds of the species copper (II), cobalt (II) and molybdenum (II) with methacrylic acid were synthesized and characterized. Besides, it realized reactions of bromine addition to the doubles links of the species obtained previously, also too like reactions with dry HCl. Finally, it got hybrids materials by polymerization of the first compounds in an acrylic matrix. Research concluded with the characterization of all the products. (author) [es

  18. Combination of Mean Platelet Volume/Platelet Count Ratio and the APACHE II Score Better Predicts the Short-Term Outcome in Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy.

    Science.gov (United States)

    Li, Junhui; Li, Yingchuan; Sheng, Xiaohua; Wang, Feng; Cheng, Dongsheng; Jian, Guihua; Li, Yongguang; Feng, Liang; Wang, Niansong

    2018-03-29

    Both the Acute physiology and Chronic Health Evaluation (APACHE II) score and mean platelet volume/platelet count Ratio (MPR) can independently predict adverse outcomes in critically ill patients. This study was aimed to investigate whether the combination of them could have a better performance in predicting prognosis of patients with acute kidney injury (AKI) who received continuous renal replacement therapy (CRRT). Two hundred twenty-three patients with AKI who underwent CRRT between January 2009 and December 2014 in a Chinese university hospital were enrolled. They were divided into survivals group and non-survivals group based on the situation at discharge. Receiver Operating Characteristic (ROC) curve was used for MPR and APACHE II score, and to determine the optimal cut-off value of MPR for in-hospital mortality. Factors associated with mortality were identified by univariate and multivariate logistic regression analysis. The mean age of the patients was 61.4 years, and the overall in-hospital mortality was 48.4%. Acute cardiorenal syndrome (ACRS) was the most common cause of AKI. The optimal cut-off value of MPR for mortality was 0.099 with an area under the ROC curve (AUC) of 0.636. The AUC increased to 0.851 with the addition of the APACHE II score. The mortality of patients with of MPR > 0.099 was 56.4%, which was significantly higher than that of the control group with of ≤ 0.099 (39.6%, P= 0.012). Logistic regression analysis showed that average number of organ failure (OR = 2.372), APACHE II score (OR = 1.187), age (OR = 1.028) and vasopressors administration (OR = 38.130) were significantly associated with poor prognosis. Severity of illness was significantly associated with prognosis of patients with AKI. The combination of MPR and APACHE II score may be helpful in predicting the short-term outcome of AKI. © 2018 The Author(s). Published by S. Karger AG, Basel.

  19. Combination of Mean Platelet Volume/Platelet Count Ratio and the APACHE II Score Better Predicts the Short-Term Outcome in Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy

    Directory of Open Access Journals (Sweden)

    Junhui Li

    2018-03-01

    Full Text Available Background/Aims: Both the Acute physiology and Chronic Health Evaluation (APACHE II score and mean platelet volume/platelet count Ratio (MPR can independently predict adverse outcomes in critically ill patients. This study was aimed to investigate whether the combination of them could have a better performance in predicting prognosis of patients with acute kidney injury (AKI who received continuous renal replacement therapy (CRRT. Methods: Two hundred twenty-three patients with AKI who underwent CRRT between January 2009 and December 2014 in a Chinese university hospital were enrolled. They were divided into survivals group and non-survivals group based on the situation at discharge. Receiver Operating Characteristic (ROC curve was used for MPR and APACHE II score, and to determine the optimal cut-off value of MPR for in-hospital mortality. Factors associated with mortality were identified by univariate and multivariate logistic regression analysis. Results: The mean age of the patients was 61.4 years, and the overall in-hospital mortality was 48.4%. Acute cardiorenal syndrome (ACRS was the most common cause of AKI. The optimal cut-off value of MPR for mortality was 0.099 with an area under the ROC curve (AUC of 0.636. The AUC increased to 0.851 with the addition of the APACHE II score. The mortality of patients with of MPR > 0.099 was 56.4%, which was significantly higher than that of the control group with of ≤ 0.099 (39.6%, P= 0.012. Logistic regression analysis showed that average number of organ failure (OR = 2.372, APACHE II score (OR = 1.187, age (OR = 1.028 and vasopressors administration (OR = 38.130 were significantly associated with poor prognosis. Conclusion: Severity of illness was significantly associated with prognosis of patients with AKI. The combination of MPR and APACHE II score may be helpful in predicting the short-term outcome of AKI.

  20. Copper (II)

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Valine (2 - amino - 3 – methylbutanoic acid), is a chemical compound containing .... Stability constant (Kf). Gibb's free energy. ) (. 1. −. ∆. Mol. JG. [CuL2(H2O)2] ... synthesis and characterization of Co(ii), Ni(ii), Cu (II), and Zn(ii) complexes with ...

  1. INTERPRETAÇÕES ACERCA DA INFLUÊNCIA DAS INFORMAÇÕES NUTRICIONAIS NA ESCOLHA DE ALIMENTOS INFANTIS

    Directory of Open Access Journals (Sweden)

    Marcelo Pais Moreira Lopes

    2013-04-01

    Full Text Available Diversos estudos têm demonstrado que, nas últimas décadas, mudanças nos hábitos alimentares vêm ocorrendo e que a proliferação de alimentos com diferentes finalidades passou a exigir do consumidor um alto nível de informação. Este artigo tem por objetivo principal investigar os fatores que influenciam a compra de alimentos infantis, observando especialmente os significados atribuídos por mães às informações nutricionais. Foram entrevistadas mães de diferentes níveis de escolaridade, renda, profissão e bairro de residência na cidade do Rio de Janeiro. O tratamento dos dados coletados ocorreu por meio da análise de conteúdo e, ao longo das entrevistas, foram questionados, por exemplo, quais fatores as mães entrevistadas consideravam importantes ao comprar alimentos para seus filhos e se tinham o costume de consultar as tabelas nutricionais dos alimentos no supermercado quando os estavam comprando. Adicionalmente, buscamos compreender o que, na perspectiva das mães, significam “alimentos pouco saudáveis” e qual conceito tinham sobre alimentos “nutritivos” e “saudáveis” - investigando se seriam sinônimos ou não. A partir de tais procedimentos, os resultados mostram que os três principais fatores que influenciam a compra de alimentos para os filhos são: i preço; ii marca; e iii a influência dos filhos. As interpretações a respeito das informações nutricionais puderam ser agrupadas em cinco categorias, quais sejam: 1 comprando besteira; 2 nutritivo versus saudável; 3 comer bem; 4 fatores importantes ao comprar alimentos para os filhos; e 5 informações nutricionais na intenção de compra.

  2. ¿Es usted socialmente responsable?

    Directory of Open Access Journals (Sweden)

    Leonel Mosquera

    2016-06-01

    El objetivo de este ensayo es dar a conocer no solo a la comunidad laica sino a la sociedad que nuestra propuesta incluye un cambio de actitud, una revolución de prácticas sociales que serán plasmadas con toda la información detallada de la realización del proyecto antes mencionado y por consiguiente, se realizará la ejecución de un Manual de procedimientos con indicadores de prácticas sociales de la Universidad Laica Vicente Rocafuerte de Guayaquil

  3. ¿Es posible el capitalismo sostenible?

    Directory of Open Access Journals (Sweden)

    James O´Connor

    2000-01-01

    Full Text Available ¿Es posible el capitalismo sostenible? En este artículo se analiza una evidencia relativa a esta pregunta, haciendo énfasis en algunos de los diferentes conceptos de "sostenibilidad" planteados por los verdes y por el sector empresarial. Se hace un breve recuento de las condiciones de sostenibilidad económica y se discute la "primera" contradicción del capitalismo y la naturaleza de la acumulación capitalista, además de un breve examen del proceso de formación de una crisis mundial en la década de los ochenta.

  4. ES 1010 software for testing CAMAC modules

    International Nuclear Information System (INIS)

    Ableev, V.G.; Basiladze, S.G.; Zaporozhets, S.A.; Piskunov, N.M.; Ryabtsov, V.D.; Sitnik, I.M.; Strokovskij, E.A.; Sharov, V.I.

    1977-01-01

    Test programs for digital and analog-digital CAMAC modules applied in physical experiments are described. Algorithms were written in FORTRAN-4 language for testing, data acquisition, processing and data control. ASSEMBLER ES 1010 subroutines were used for data acquisition and CAMAC module control. This allowed one to take advantages of a high level language for data processing and display, as well as for achieving an interface with the CAMAC hardware. Software applied enables one to improve considerably adjustment of CAMAC modules and to obtain their operational characteristics

  5. The influence of temperature on low cycle fatigue behavior of prior cold worked 316L stainless steel (II) : life prediction and failure mechanism

    International Nuclear Information System (INIS)

    Hong, Seong Gu; Yoon, Sam Son; Lee, Soon Bok

    2003-01-01

    Tensile and low cycle fatigue tests on prior cold worked 316L stainless steel were carried out at various temperatures from room temperature to 650 deg. C. Fatigue resistance was decreased with increasing temperature and decreasing strain rate. Cyclic plastic deformation, creep, oxidation and interactions with each other are thought to be responsible for the reduction in fatigue resistance. Currently favored life prediction models were examined and it was found that it is important to select a proper life prediction parameter since stress-strain relation strongly depends on temperature. A phenomenological life prediction model was proposed to account for the influence of temperature on fatigue life and assessed by comparing with experimental result. LCF failure mechanism was investigated by observing fracture surfaces of LCF failed specimens with SEM

  6. Basic Diagnosis and Prediction of Persistent Contrail Occurrence using High-resolution Numerical Weather Analyses/Forecasts and Logistic Regression. Part II: Evaluation of Sample Models

    Science.gov (United States)

    Duda, David P.; Minnis, Patrick

    2009-01-01

    Previous studies have shown that probabilistic forecasting may be a useful method for predicting persistent contrail formation. A probabilistic forecast to accurately predict contrail formation over the contiguous United States (CONUS) is created by using meteorological data based on hourly meteorological analyses from the Advanced Regional Prediction System (ARPS) and from the Rapid Update Cycle (RUC) as well as GOES water vapor channel measurements, combined with surface and satellite observations of contrails. Two groups of logistic models were created. The first group of models (SURFACE models) is based on surface-based contrail observations supplemented with satellite observations of contrail occurrence. The second group of models (OUTBREAK models) is derived from a selected subgroup of satellite-based observations of widespread persistent contrails. The mean accuracies for both the SURFACE and OUTBREAK models typically exceeded 75 percent when based on the RUC or ARPS analysis data, but decreased when the logistic models were derived from ARPS forecast data.

  7. Accuracy of a composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 h.

    Science.gov (United States)

    Timsit, J F; Fosse, J P; Troché, G; De Lassence, A; Alberti, C; Garrouste-Orgeas, M; Azoulay, E; Chevret, S; Moine, P; Cohen, Y

    2001-06-01

    In most databases used to build general severity scores the median duration of intensive care unit (ICU) stay is less than 3 days. Consequently, these scores are not the most appropriate tools for measuring prognosis in studies dealing with ICU patients hospitalized for more than 72 h. To develop a new prognostic model based on a general severity score (SAPS II), an organ dysfunction score (LOD) and evolution of both scores during the first 3 days of ICU stay. Prospective multicenter study. Twenty-eight intensive care units (ICUs) in France. A training data-set was created with four ICUs during an 18-month period (893 patients). Seventy percent of the patients were medical (628) aged 66 years. The median SAPS II was 38. The ICU and hospital mortality rates were 22.7% and 30%, respectively. Forty-seven percent (420 patients) were transferred from hospital wards. In this population, the calibration (Hosmer-Lemeshow chi-square: 37.4, P = 0.001) and the discrimination [area under the ROC curves: 0.744 (95 % CI: 0.714-0.773)] of the original SAPS II were relatively poor. A validation data set was created with a random panel of 24 French ICUs during March 1999 (312 patients). The LOD and SAPS II scores were calculated during the first (SAPS1, LOD1), second (SAPS2, LOD2), and third (SAPS3, LOD3) calendar days. The LOD and SAPS scores alterations were assigned the value "1" when scores increased with time and "0" otherwise. A multivariable logistic regression model was used to select variables measured during the first three calendar days, and independently associated with death. Selected variables were: SAPS II at admission [OR: 1.04 (95 % CI: 1.027-1.053) per point], LOD [OR: 1.16 (95 % CI: 1.085-1.253) per point], transfer from ward [OR: 1.74 (95 % CI: 1.25-2.42)], as well as SAPS3-SAPS2 alterations [OR: 1.516 (95 % CI: 1.04-2.22)], and LOD3-LOD2 alterations [OR: 2.00 (95 % CI: 1.29-3.11)]. The final model has good calibration and discrimination properties in the

  8. Circulating Tyrosinase and MART-1 mRNA does not Independently Predict Relapse or Survival in Patients with AJCC Stage I–II Melanoma

    DEFF Research Database (Denmark)

    Schmidt, Henrik; Sørensen, Boe S; Sjoegren, Pia

    2006-01-01

    The detection of melanoma cells in peripheral blood has been proposed to select patients with a high risk of relapse. In this study, tyrosinase and melanoma antigen recognized by T cells 1 (MART-1) mRNA expression was evaluated in serial samples obtained before definitive surgery and during follow......-up in patients with American Joint Committee on Cancer stage I-II melanoma. Serial samples (n=2,262) were collected from 236 patients from 1997 to 2002. Analyses of the RNA samples were performed with a calibrated reverse transcriptase-PCR assay. Gender, age, primary tumor site, ulceration, thickness, Clark...

  9. Serum YKL-40 Predicts Relapse-Free and Overall Survival in Patients With American Joint Committee on Cancer Stage I and II Melanoma

    DEFF Research Database (Denmark)

    Schmidt, Henrik; Johansen, Julia S; Sjoegren, Pia

    2006-01-01

    level has been associated with poor prognosis in patients with several cancer types. PATIENTS AND METHODS: Serum samples from 234 patients with stage I (n = 162) and II (n = 72) melanoma were analyzed for YKL-40 by enzyme-linked immunosorbent assay. Serial samples were obtained before definitive primary...... surgery and during follow-up. RESULTS: After a median follow-up period of 66 months (range, 1 to 97 months), 41 relapses (18%) and 39 deaths (17%) were observed. Serum YKL-40 treated as an updated continuous covariate were analyzed together with the covariates sex, age, primary tumor site, ulceration...

  10. Un guijarro no es un canto rodado

    Directory of Open Access Journals (Sweden)

    Coronado Castillo, Ángel

    2006-06-01

    Full Text Available The sense or meaning of a word resides in thought and only manifests itself when the word is used. Yet the sense conveyed can be equivocal if the word is taken out of its context, spatial as well as temporal. Considering the present time then, we are dealing with the determination of a space, with exploring around the contextual area. The study that resulted in this paper involves geography, but is no geographical research; at most research on human geography. Although it involves speech, its direct object is not language. Neither it is, in strictness, ethnography nor cultural anthropology. But it concerns all of these fields and, therefore, cannot stay away from any of them. Only one concept, perhaps, overrides the whole undertaking and meets the double condition of being simple and complex at the same time: the concept of elementary area. This concept rests upon the seminal idea of taking the sense and meaning of something (in this case, a name or a noun as the use given to such something (such name or noun in a particular space: a here and a now. One word or signifier, one single meaning; that is all there is. Yet it is this extreme simplification that which allows freedom of speculation, clear and refined.

    El sentido de una palabra está en el pensamiento y sólo se hace manifiesto a través de dicha palabra. Pero la información que conlleva la misma es equívoca si hacemos abstracción de un lugar y de un tiempo. Sea el tiempo actual. Se trata, pues, de la determinación de un lugar, de indagar acerca del territorio. El estudio propuesto trata, pues, de geografía, pero no es geografía; acaso geografía humana. Concierne al habla, pero su objeto directo no es la lengua. No es tampoco, en sentido estricto, etnografía ni antropología cultural. Pero siendo un poco todo ello, no puede prescindir de nada. Sólo uno de sus conceptos, quizá, presida todo el conjunto y reúna la doble condición de ser complejo y a la vez simple:

  11. Lifetime prediction of EC, DPA, akardite II and MNA stabilized triple base propellants, comparison of heat generation rate and stabilizer consumption

    NARCIS (Netherlands)

    Boers, M.N.; Klerk, W.P.C. de

    2005-01-01

    A lifetime prediction study is carried out on four triple base propellant compositions by artificial ageing. The ageing effects are studied with High Performance Liquid Chromatography (HPLC) and Heat Flow Calorimetry (HFC) in order to find the most effective stabilizer and to evaluate the advantages

  12. Lifetime prediction of EC, DPA, Akardite II and MNA stabilized triple base propellants, comparison of heat generation rate and stabilizer consumption

    Energy Technology Data Exchange (ETDEWEB)

    Boers, Marco N.; Klerk, Willem (Wim) P.C. de [TNO Defence, Security and Safety, P. O. Box 45, 2280 AA Rijswijk ZH (Netherlands)

    2005-10-01

    A lifetime prediction study is carried out on four triple base propellant compositions by artificial ageing. The ageing effects are studied with High Performance Liquid Chromatography (HPLC) and Heat Flow Calorimetry (HFC) in order to find the most effective stabilizer and to evaluate the advantages and disadvantages of both methods. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

  13. Prediction of mineral scale formation in geothermal and oilfield operations using the Extended UNIQUAC model - Part II. Carbonate-scaling minerals

    DEFF Research Database (Denmark)

    Villafafila, Ada; Thomsen, Kaj; Stenby, Erling Halfdan

    2006-01-01

    Two additional parameters to account for the pressure dependency of solubility are added to the Extended UNIQUAC model presented by Thomsen and Rasmussen (1999). The improved model has been used for correlation and prediction of vapor-liquid-solid equilibrium for different carbonate systems (CaCO...

  14. Incremental Validity of WISC-IV[superscript UK] Factor Index Scores with a Referred Irish Sample: Predicting Performance on the WIAT-II[superscript UK

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.; James, Trevor; Good, Rebecca; James, Kate

    2014-01-01

    Background: Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. Aims: This study examined the incremental validity of Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004a, "Wechsler Intelligence Scale for Children-Fourth UK…

  15. CAUSAS DE MORTE E RAZÕES PARA EUTANÁSIA DE CÃES

    OpenAIRE

    Rafael Almeida Fighera

    2008-01-01

    A crescente aproximação afetiva entre os cães e o homem fez com que nos últimos anos fosse gerada muita informação científica sobre medicina canina. Entretanto, como a maior parte dessas informações é obtida através da literatura internacional, é comum que os clínicos e patologistas veterinários brasileiros necessitem extrapolar dados referentes à prevalência das diferentes doenças que causam morte de cães para nossa realidade. Baseado nisso, este estudo tem como objetivo principal dete...

  16. Toward the prediction of class I and II mouse major histocompatibility complex-peptide-binding affinity: in silico bioinformatic step-by-step guide using quantitative structure-activity relationships.

    Science.gov (United States)

    Hattotuwagama, Channa K; Doytchinova, Irini A; Flower, Darren R

    2007-01-01

    Quantitative structure-activity relationship (QSAR) analysis is a cornerstone of modern informatics. Predictive computational models of peptide-major histocompatibility complex (MHC)-binding affinity based on QSAR technology have now become important components of modern computational immunovaccinology. Historically, such approaches have been built around semiqualitative, classification methods, but these are now giving way to quantitative regression methods. We review three methods--a 2D-QSAR additive-partial least squares (PLS) and a 3D-QSAR comparative molecular similarity index analysis (CoMSIA) method--which can identify the sequence dependence of peptide-binding specificity for various class I MHC alleles from the reported binding affinities (IC50) of peptide sets. The third method is an iterative self-consistent (ISC) PLS-based additive method, which is a recently developed extension to the additive method for the affinity prediction of class II peptides. The QSAR methods presented here have established themselves as immunoinformatic techniques complementary to existing methodology, useful in the quantitative prediction of binding affinity: current methods for the in silico identification of T-cell epitopes (which form the basis of many vaccines, diagnostics, and reagents) rely on the accurate computational prediction of peptide-MHC affinity. We have reviewed various human and mouse class I and class II allele models. Studied alleles comprise HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3101, HLA-A*6801, HLA-A*6802, HLA-B*3501, H2-K(k), H2-K(b), H2-D(b) HLA-DRB1*0101, HLA-DRB1*0401, HLA-DRB1*0701, I-A(b), I-A(d), I-A(k), I-A(S), I-E(d), and I-E(k). In this chapter we show a step-by-step guide into predicting the reliability and the resulting models to represent an advance on existing methods. The peptides used in this study are available from the AntiJen database (http://www.jenner.ac.uk/AntiJen). The PLS method

  17. Sub-seasonal prediction of significant wave heights over the Western Pacific and Indian Oceans, part II: The impact of ENSO and MJO

    Science.gov (United States)

    Shukla, Ravi P.; Kinter, James L.; Shin, Chul-Su

    2018-03-01

    This study evaluates the effect of El Niño and the Southern Oscillation (ENSO) and Madden Julian Oscillation (MJO) events on 14-day mean significant wave height (SWH) at 3 weeks lead time (Wk34) over the Western Pacific and Indian Oceans using the National Centers for Environmental Prediction (NCEP) Climate Forecast System, version 2 (CFSv2). The WAVEWATCH-3 (WW3) model is forced with daily 10m-winds predicted by a modified version of CFSv2 that is initialized with multiple ocean analyses in both January and May for 1979-2008. A significant anomaly correlation of predicted and observed SWH anomalies (SWHA) at Wk34 lead-time is found over portions of the domain, including the central western Pacific, South China Sea (SCS), Bay of Bengal (BOB) and southern Indian Ocean (IO) in January cases, and over BOB, equatorial western Pacific, the Maritime Continent and southern IO in May cases. The model successfully predicts almost all the important features of the observed composite SWHA during El Niño events in January, including negative SWHA in the central IO where westerly wind anomalies act on an easterly mean state, and positive SWHA over the southern Ocean (SO) where westerly wind anomalies act on a westerly mean state. The model successfully predicts the sign and magnitude of SWHA at Wk34 lead-time in May over the BOB and SCS in composites of combined phases-2-3 and phases-6-7 of MJO. The observed leading mode of SWHA in May and the third mode of SWHA in January are influenced by the combined effects of ENSO and MJO. Based on spatial and temporal correlations, the spatial patterns of SWHA in the model at Wk34 in both January and May are in good agreement with the observations over the equatorial western Pacific, equatorial and southern IO, and SO.

  18. Neurochemical and structural markers in the brain predicting best choice-of-treatment in patients with schizophrenia - The Pan European Collaboration on Antipsychotic Naïve Schizophrenia II (PECANS II) study

    DEFF Research Database (Denmark)

    Jessen, Kasper; Bojesen, Kirsten Borup; Sigvard, Anne Mette

    Background: Insufficient treatment response to dopaminergic antipsychotics constitutes a major challenge in the treatment of patients with schizophrenia and seems to be related to persistently high levels of the neurotransmitter glutamate. Excess glutamate is neurotoxic and may cause the progress......Background: Insufficient treatment response to dopaminergic antipsychotics constitutes a major challenge in the treatment of patients with schizophrenia and seems to be related to persistently high levels of the neurotransmitter glutamate. Excess glutamate is neurotoxic and may cause...... subgroup with good treatment response. Materials and methods: PECANS II is a prospective follow-up study of 60 initial antipsychotic naïve patients with schizophrenia and 60 matched healthy controls. Brain levels of glutamate are measured with proton magnetic resonance imaging (1H-MRS), dopaminergic...... rating scales. All examinations are performed before and after 6 weeks’ treatment with a partial dopamine agonist (aripiprazole), and further after 6 months and 2 years. Patients are also examined with neuropsychological and psychophysiological test batteries as part of co-operating projects. Results...

  19. (II) complexes

    African Journals Online (AJOL)

    activities of Schiff base tin (II) complexes. Neelofar1 ... Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and ...... Singh HL. Synthesis and characterization of tin (II) complexes of fluorinated Schiff bases derived from amino acids. Spectrochim Acta Part A: Molec Biomolec.

  20. Assessment on Vulnerable Youths Integration to Dar es Salaam ...

    African Journals Online (AJOL)

    Assessment on Vulnerable Youths Integration to Dar es Salaam Solid Waste ... existing municipal solid waste management crisis facing Dar es Salaam City using ... enabling environment of turning rampant solid waste collection a commercial ...

  1. El significante no es un arquetipo

    OpenAIRE

    Murillo, Manuel

    2014-01-01

    Este artículo forma parte de la investigación de maestría La hipótesis de los tres registros. Sujeto, metapsicología y formalización en psicoanálisis (Murillo, 2010, 2011a, 2011b, 2011c, 2012a, 2012b, 2013a, 2013b) y la investigación UBACyT Lógicas de producción en el campo de investigaciones en psicoanálisis (Azaretto y Ros, 2011). El objetivo de este artículo es desarrollar la referencia de Jung en el desarrollo de la hipótesis de lo simbólico, o de la teoría del simbolismo. Se concluye que...

  2. CD133 expression is not an independent prognostic factor in stage II and III colorectal cancer but may predict the better outcome in patients with adjuvant therapy

    International Nuclear Information System (INIS)

    Mia-Jan, Khalilullah; Jung, So Young; Kim, Ik-Yong; Oh, Sung Soo; Choi, EunHee; Chang, Sei Jin; Kang, Tae Young; Cho, Mee-Yon

    2013-01-01

    Cancer stem cells (CSCs) are notorious for their capacity of tumor progression, metastasis or resistance to chemo-radiotherapy. However, the undisputed role of cancer stem marker, CD133, in colorectal cancers (CRCs) is not clear yet. We assessed 271 surgically-resected stage II and III primary CRCs with (171) and without (100) adjuvant therapy after surgery. CD133 expression was analyzed by immunohistochemical (IHC) staining and real-time RT-PCR. CD133 promoter methylation was quantified by pyrosequencing. The CD133 IHC expression was significantly correlated with mRNA expression (p=0.0257) and inversely correlated with the promoter methylation (p=0.0001). CD133 was expressed more frequently in rectal cancer (p=0.0035), and in moderately differentiated tumors (p=0.0378). In survival analysis, CD133 expression was not significantly correlated with overall survival (OS) (p=0.9689) as well as disease-free survival (DFS) (p=0.2103). However, CD133+ tumors were significantly associated with better OS in patients with adjuvant therapy compared to those without adjuvant therapy (p<0.0001, HR 0.125, 95% CI 0.052-0.299). But the patients with CD133- tumors did not show any significant difference of survival according to adjuvant therapy (p=0.055, HR 0.500, 95% CI 0.247-1.015). In stage II and III CRCs, CD133 IHC expression may signify the benefit for adjuvant therapy although it is not an independent prognostic factor

  3. The APACHE II measured on patients' discharge from the Intensive Care Unit in the prediction of mortality APACHE II medido en la salida de los pacientes de la Unidad de Terapia Intensiva en la previsión de la mortalidad APACHE II medido na saída dos pacientes da Unidade de Terapia Intensiva na previsão da mortalidade

    Directory of Open Access Journals (Sweden)

    Luciana Gonzaga dos Santos Cardoso

    2013-06-01

    Full Text Available OBJECTIVE: to analyze the performance of the Acute Physiology and Chronic Health Evaluation (APACHE II, measured based on the data from the last 24 hours of hospitalization in ICU, for patients transferred to the wards. METHOD: an observational, prospective and quantitative study using the data from 355 patients admitted to the ICU between January and July 2010, who were transferred to the wards. RESULTS: the discriminatory power of the AII-OUT prognostic index showed a statistically significant area beneath the ROC curve. The mortality observed in the sample was slightly greater than that predicted by the AII-OUT, with a Standardized Mortality Ratio of 1.12. In the calibration curve the linear regression analysis showed the R2 value to be statistically significant. CONCLUSION: the AII-OUT could predict mortality after discharge from ICU, with the observed mortality being slightly greater than that predicted, which shows good discrimination and good calibration. This system was shown to be useful for stratifying the patients at greater risk of death after discharge from ICU. This fact deserves special attention from health professionals, particularly nurses, in managing human and technological resources for this group of patients. OBJETIVO: analizar el desempeño del Acute Physiology and Chronic Health Evaluation (APACHE II, medido con base en los datos de la últims 24 horas de internación en la UTI, en los pacientes con transferencia para las enfermerías. MÉTODO: estudio observacional, prospectivo y cuantitativo con datos de 355 pacientes admitidos en la UTI entre enero y julio de 2010 que fueron transferidos para las enfermerías. RESULTADOS: el poder discriminatorio del índice pronóstico AII-SALIDA demostró un área debajo de la curva ROC estadísticamente significativa. La mortalidad observada en la muestra fue discretamente mayor que la prevista por el AII-SALIDA, con una Razón de Mortalidad Estandarizada de 1,12. En la curva de

  4. INNOVACIÓN: LO SOCIAL LE ES INMANENTE

    Directory of Open Access Journals (Sweden)

    GIOVANNI ARTURO LÓPEZ ISAZA

    2014-01-01

    Full Text Available En el marco del proyecto de investigación doctoral “Emprenderismo/educación, innovación/edu - cación, empleo/educación: lenguajes que atrapan sentidos”, este documento recoge aportes sobre la innovación social, indagando con una ventana de observación 2000-2013, en las bases de in - formación: Science Direct, Scopus, Springer Link, Google books, Google y otros actores ubicados en América y Europa. Dos conclusiones emergen de este documento: (i El hilo conductor de los discursos sobre innovación social, indica que ella es comprendida como proceso social y como fenómeno emergente, en el contexto de prácticas ciudadanas que enfrentan problemas sociales; pri - vilegiando intereses colectivos sobre individuales, fortaleciendo las capacidades de unos y de otros actores sociales. (ii La educación/comunicación abre, penetra y altera mentes; le otorga sentido a la innovación, como constructo y esperanza social; con la participación/conversación de ciudadanos plurales y totales, favorece fusiones creativas que configuran innovación social.

  5. Solute transport in crystalline rocks at Äspö — II: Blind predictions, inverse modelling and lessons learnt from test STT1

    Science.gov (United States)

    Jakob, Andreas; Mazurek, Martin; Heer, Walter

    2003-03-01

    Based on the results from detailed structural and petrological characterisation and on up-scaled laboratory values for sorption and diffusion, blind predictions were made for the STT1 dipole tracer test performed in the Swedish Äspö Hard Rock Laboratory. The tracers used were nonsorbing, such as uranine and tritiated water, weakly sorbing 22Na +, 85Sr 2+, 47Ca 2+and more strongly sorbing 86Rb +, 133Ba 2+, 137Cs +. Our model consists of two parts: (1) a flow part based on a 2D-streamtube formalism accounting for the natural background flow field and with an underlying homogeneous and isotropic transmissivity field and (2) a transport part in terms of the dual porosity medium approach which is linked to the flow part by the flow porosity. The calibration of the model was done using the data from one single uranine breakthrough (PDT3). The study clearly showed that matrix diffusion into a highly porous material, fault gouge, had to be included in our model evidenced by the characteristic shape of the breakthrough curve and in line with geological observations. After the disclosure of the measurements, it turned out that, in spite of the simplicity of our model, the prediction for the nonsorbing and weakly sorbing tracers was fairly good. The blind prediction for the more strongly sorbing tracers was in general less accurate. The reason for the good predictions is deemed to be the result of the choice of a model structure strongly based on geological observation. The breakthrough curves were inversely modelled to determine in situ values for the transport parameters and to draw consequences on the model structure applied. For good fits, only one additional fracture family in contact with cataclasite had to be taken into account, but no new transport mechanisms had to be invoked. The in situ values for the effective diffusion coefficient for fault gouge are a factor of 2-15 larger than the laboratory data. For cataclasite, both data sets have values comparable to

  6. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_TRMM-PFM_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=1998-08-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  7. Everglades Ecological Forecasting II: Utilizing NASA Earth Observations to Enhance the Capabilities of Everglades National Park to Monitor & Predict Mangrove Extent to Aid Current Restoration Efforts

    Science.gov (United States)

    Kirk, Donnie; Wolfe, Amy; Ba, Adama; Nyquist, Mckenzie; Rhodes, Tyler; Toner, Caitlin; Cabosky, Rachel; Gotschalk, Emily; Gregory, Brad; Kendall, Candace

    2016-01-01

    Mangroves act as a transition zone between fresh and salt water habitats by filtering and indicating salinity levels along the coast of the Florida Everglades. However, dredging and canals built in the early 1900s depleted the Everglades of much of its freshwater resources. In an attempt to assist in maintaining the health of threatened habitats, efforts have been made within Everglades National Park to rebalance the ecosystem and adhere to sustainably managing mangrove forests. The Everglades Ecological Forecasting II team utilized Google Earth Engine API and satellite imagery from Landsat 5, 7, and 8 to continuously create land-change maps over a 25 year period, and to allow park officials to continue producing maps in the future. In order to make the process replicable for project partners at Everglades National Park, the team was able to conduct a supervised classification approach to display mangrove regions in 1995, 2000, 2005, 2010 and 2015. As freshwater was depleted, mangroves encroached further inland and freshwater marshes declined. The current extent map, along with transition maps helped create forecasting models that show mangrove encroachment further inland in the year 2030 as well. This project highlights the changes to the Everglade habitats in relation to a changing climate and hydrological changes throughout the park.

  8. Modelling the petroleum generation and migration of the third member of the Shahejie Formation (Es3) in the Banqiao Depression of Bohai Bay Basin, Eastern China

    Science.gov (United States)

    Guo, Xiaowen; He, Sheng; Liu, Keyu; Shi, Zhongsheng; Bachir, Sani

    2011-01-01

    structure surfaces at 26 Ma and present-day, respectively. The migration history modelling results have accurately predicted the petroleum occurrences within the Es3 member of the Banqiao Depression based on the calibration with drilling results of 10 oil-producing wells, one well with oil shows and 52 dry holes. Six favorable zones of oil accumulations in the Es3 member of the Banqiao Depression are identified especially oil accumulation zones I and II due to their proximity to the generative kitchens, short oil migration distances and the presence of a powerful drive force.

  9. ¿Es posible objetivar el dolor?

    Directory of Open Access Journals (Sweden)

    DR. S. Mario Campero

    2014-07-01

    Full Text Available El dolor es una experiencia cognitiva como resultado de la activación de nociceptores o descritas en esos términos. El estímulo nociceptivo desencadena la activación de redes neuronales que procesan la información en forma paralela y distribuida, con un componente discriminativo en el tálamo y corteza primaria contra lateral y otro afectivo en la corteza del cíngulo anterior y prefrontal dorsolateral. El dolor como experiencia psíquica solo puede ser objetivado en sus aspectos de activación de las áreas de la así llamada matriz de dolor, mediante la técnica de resonancia magnética funcional. Con el registro de la actividad de nociceptores en sujetos despiertos y en pacientes con dolor neuropático mediante microneurografía se puede relacionar la actividad anormal en estos receptores con la sensación evocada.

  10. Linfossarcoma em cães

    Directory of Open Access Journals (Sweden)

    Fighera Rafael Almeida

    2002-01-01

    Full Text Available O linfossarcoma é uma neoplasia linfóide que se origina em órgão sólido e que, em cães, não tem ainda uma etiologia determinada. O diagnóstico dessa neoplasia pode ser feito tanto por citologia como por histopatologia, embora, muitas vezes, sua diferenciação de leucemia linfóide seja difícil. Vários sinais clínicos são associados com o linfossarcoma canino, a maioria deles relacionada ao órgão na qual o tumor se localiza. Uma manifestação comum é a linfadenopatia generalizada que deve ser diferenciada de outras enfermidades que causam aumento de volume dos linfonodos. Algumas síndromes paraneoplásicas complicam casos de linfossarcoma e, muitas vezes, são responsáveis pela morte do animal. Neste trabalho, são revisados os aspectos clínicos, laboratoriais, as alterações de necropsia e histopatologia do linfossarcoma canino.

  11. La convivencia no es tan obvia

    Directory of Open Access Journals (Sweden)

    Alicia García-Dalmás

    2015-08-01

    Full Text Available La promoción de una mejor convivencia a través de la generación o mejora de espacios públicos, básicamente plazas y parques, sigue siendo una de las principales propuestas con las que las políticas públicas, por lo menos en Uruguay, buscan dar respuesta a lo que identifican como “problemas sociales acuciantes”: la violencia, la inseguridad. El presente artículo toma como base una propuesta, la Estrategia por la Vida y la Convivencia, impulsada por el gobierno nacional que, entre otros aspectos, plantea que “el pacto de convivencia es un pacto de obviedad”. Desde la comunicación propone aproximaciones y preguntas que buscan desnaturalizar lo obvio, profundizar en cómo se construyen vínculos y sentidos en relación a los territorios y la cotidianidad de quienes los habitan.

  12. El Pseudo-Hiepes es Bernardo Polo

    Directory of Open Access Journals (Sweden)

    Jordan, William B.

    2009-12-01

    Full Text Available Nearly fifteen years ago, the author proposed the name Pseudo-Hiepes to refer to a then anonymous painter whom certain Italian art historians had called the Master of the Lombard Fruit Bowl. At the time, he argued for an Aragonese origin in the later part of the century. A signed work has finally been discovered and is published here. The artist was indeed from Zaragoza, and his name is Bernardo Polo.

    Hace unos quince años, el autor propuso el apodo Pseudo-Hiepes para identificar al pintor anónimo a quien algunos entendidos italianos habían bautizado como Maestro del Frutero lombardo. En aquel entonces, argumentó que debía tratarse de un artista aragonés, de la segunda mitad de siglo. Por fin ha aparecido una obra firmada que se presenta aquí. Efectivamente, el artista era zaragozano y su nombre es Bernardo Polo.

  13. La ciudad es un libro abierto

    Directory of Open Access Journals (Sweden)

    Fernando Carrión M.

    2015-01-01

    Full Text Available A nivel urbano se producen cambios en la relación comunicación y ciudad que se expresan en las nuevas formas de articulación interurbana, población-ciudad, gobierno local-sociedad y redes sociales. El autor señala las características que hacen de la ciudad un medio de comunicación y enfatiza en la necesidad de que los municipios trabajen por el fortalecimiento de la articulación social de mediación de lo público. Compara al libro y la ciudad como textos abiertos. Señala que las ciudades tienen una nomenclatura que obliga a ser leídas. La estructura simbólica de la ciudad está compuesta por un conjunto de signos que facilitan el establecimiento de contactos entre la sociedad y el espacio que la contiene, así como la apertura de ámbitos de relación entre la cultura y la naturaleza. La ciudad es un foro de comunicación e información, porque en ella confluye la mayor densidad de medios de comunicación y usuarios; abarca la mayor concentración de lugares de socialización; posee el mayor cúmulo de información concentrada y tiene acumuladas la mayor cantidad de manifestaciones simbólicas.

  14. Implications of secondary structure prediction and amino acid sequence comparison of class I and class II phosphoribosyl diphosphate synthases on catalysis, regulation, and quaternary structure

    DEFF Research Database (Denmark)

    Krath, B N; Hove-Jensen, B

    2001-01-01

    Spinach 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) synthase isozyme 4 was synthesized in Escherichia coli and purified to near homogeneity. The activity of the enzyme is independent of P(i); it is inhibited by ADP in a competitive manner, indicating a lack of an allosteric site; and it accepts...... is consistent with a homotrimer. Secondary structure prediction shows that spinach PRPP synthase isozyme 4 has a general folding similar to that of Bacillus subtilis class I PRPP synthase, for which the three-dimensional structure has been solved, as the position and extent of helices and beta-sheets of the two...... in the spinach enzyme. In contrast, residues of the active site of B. subtilis PRPP synthase show extensive conservation in spinach PRPP synthase isozyme 4....

  15. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES4_TRMM-PFM_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=1998-08-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  16. Quantitative coronary plaque analysis predicts high-risk plaque morphology on coronary computed tomography angiography: results from the ROMICAT II trial.

    Science.gov (United States)

    Liu, Ting; Maurovich-Horvat, Pál; Mayrhofer, Thomas; Puchner, Stefan B; Lu, Michael T; Ghemigian, Khristine; Kitslaar, Pieter H; Broersen, Alexander; Pursnani, Amit; Hoffmann, Udo; Ferencik, Maros

    2018-02-01

    Semi-automated software can provide quantitative assessment of atherosclerotic plaques on coronary CT angiography (CTA). The relationship between established qualitative high-risk plaque features and quantitative plaque measurements has not been studied. We analyzed the association between quantitative plaque measurements and qualitative high-risk plaque features on coronary CTA. We included 260 patients with plaque who underwent coronary CTA in the Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography (ROMICAT) II trial. Quantitative plaque assessment and qualitative plaque characterization were performed on a per coronary segment basis. Quantitative coronary plaque measurements included plaque volume, plaque burden, remodeling index, and diameter stenosis. In qualitative analysis, high-risk plaque was present if positive remodeling, low CT attenuation plaque, napkin-ring sign or spotty calcium were detected. Univariable and multivariable logistic regression analyses were performed to assess the association between quantitative and qualitative high-risk plaque assessment. Among 888 segments with coronary plaque, high-risk plaque was present in 391 (44.0%) segments by qualitative analysis. In quantitative analysis, segments with high-risk plaque had higher total plaque volume, low CT attenuation plaque volume, plaque burden and remodeling index. Quantitatively assessed low CT attenuation plaque volume (odds ratio 1.12 per 1 mm 3 , 95% CI 1.04-1.21), positive remodeling (odds ratio 1.25 per 0.1, 95% CI 1.10-1.41) and plaque burden (odds ratio 1.53 per 0.1, 95% CI 1.08-2.16) were associated with high-risk plaque. Quantitative coronary plaque characteristics (low CT attenuation plaque volume, positive remodeling and plaque burden) measured by semi-automated software correlated with qualitative assessment of high-risk plaque features.

  17. Complex microcirculation patterns detected by confocal indocyanine green angiography predict time to growth of small choroidal melanocytic tumors: MuSIC Report II.

    Science.gov (United States)

    Mueller, Arthur J; Freeman, William R; Schaller, Ulrich C; Kampik, Anselm; Folberg, Robert

    2002-12-01

    Multiple independent laboratories have confirmed the histologic observation that some tumor microcirculation patterns (MCPs) in uveal melanomas are associated strongly with death resulting from metastatic disease. Because these patterns are imageable with confocal indocyanine green angiography (ICG), we designed a prospective study to evaluate whether these angiographically detectable MCPs predict time to tumor growth. Observational case series, prospective, non-randomized. Ninety-eight patients with unilateral, small, choroidal melanocytic tumors. The following information and tumor characteristics were recorded for each patient: demographic parameters, best-corrected visual acuity, intraocular pressure, related visual symptoms, location and dimension of tumor, pigmentation, orange pigment, drusen, tumor-associated hemorrhage, subretinal fluid, and confocal ICG angiographically determined microcirculation patterns-silent (avascularity), normal (preexisting normal choroidal vessels within the tumor), straight vessels, parallel without and with cross-linking, arcs without and with branching, loops, and networks. Time to growth of the tumor, with growth defined as an increase in the maximal apical tumor height of 0.5 mm measured by standardized A-scan ultrasonography, photographic documentation of an increase of the largest basal diameter of at least 1.5 mm, advancement of one tumor border of at least 0.75 mm, or a combination thereof. Twenty-eight of the 98 tumors in this study (29%) met the predetermined criteria for tumor growth. The median time to growth was 127 days (range, 51-625 days). The following tumor characteristics were significantly associated with time to tumor growth: flashes (P = 0.0224), orange pigment (P = 0.012), subretinal fluid (P < 0.001), maximum basal tumor diameter at initial examination (P = 0.015), maximum apical tumor height (P < 0.001), parallel with cross-linking MCP (P < 0.001), arcs with branching MCP (P = 0.006), loops (P < 0

  18. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_TRMM-PFM_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  19. Me, Myself, and Money II: Relative Deprivation Predicts Disordered Gambling Severity via Delay Discounting, Especially Among Gamblers Who Have a Financially Focused Self-Concept.

    Science.gov (United States)

    Tabri, Nassim; Will Shead, N; Wohl, Michael J A

    2017-12-01

    In the current research, we examined whether the known link between relative deprivation and disordered gambling (via delay discounting; i.e., preferences for immediate smaller rewards relative to delayed larger rewards) is moderated by the extent to which gamblers have a financially focused self-concept. Specifically, we hypothesized that delay discounting would be a strong predictor of disordered gambling among those who base their self-worth on their financial success. To test this moderated-mediation model, a community sample of gamblers (N = 239) completed measures that assessed relative deprivation, delay discounting, financially focused self-concept, and disordered gambling severity. As predicted, people who felt more relative deprivation reported more severe symptoms of disordered gambling and this association was mediated by delay discounting. Importantly, this mediated relationship was moderated by the extent to which participants' self-concept was focused on financial success. Among participants whose self-concept was high in financial focus, greater delay discounting (stemming from relative deprivation) was a strong predictor of disordered gambling. Among people whose self-concept was low in financial focus, delay discounting (stemming from relative deprivation) was a weak predictor of disordered gambling. Thus, the magnitude of the indirect effect of relative deprivation on disordered gambling severity was larger among people with a more financially focused self-concept-an effect mediated by delay discounting. These findings suggest that targeting gamblers' financial focus in prevention and treatment interventions may be instrumental in curtailing the development and maintenance of disordered gambling.

  20. Low antigenicity of hematopoietic progenitor cells derived from human ES cells

    Directory of Open Access Journals (Sweden)

    Eun-Mi Kim

    2010-02-01

    Full Text Available Eun-Mi Kim1, Nicholas Zavazava1,21Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa, USA; 2Immunology Graduate Program, University of Iowa, Iowa City, Iowa, USAAbstract: Human embryonic stem (hES cells are essential for improved understanding of diseases and our ability to probe new therapies for use in humans. Currently, bone marrow cells and cord blood cells are used for transplantation into patients with hematopoietic malignancies, immunodeficiencies and in some cases for the treatment of autoimmune diseases. However, due to the high immunogenicity of these hematopoietic cells, toxic regimens of drugs are required for preconditioning and prevention of rejection. Here, we investigated the efficiency of deriving hematopoietic progenitor cells (HPCs from the hES cell line H13, after co-culturing with the murine stromal cell line OP9. We show that HPCs derived from the H13 ES cells poorly express major histocompatibility complex (MHC class I and no detectable class II antigens (HLA-DR. These characteristics make hES cell-derived hematopoietic cells (HPCs ideal candidates for transplantation across MHC barriers under minimal immunosuppression.Keywords: human embryonic stem cells, H13, hematopoiesis, OP9 stromal cells, immunogenicity

  1. Effect of gastric pH on the pharmacokinetics of a BCS class II compound in dogs: utilization of an artificial stomach and duodenum dissolution model and GastroPlus,™ simulations to predict absorption.

    Science.gov (United States)

    Bhattachar, Shobha N; Perkins, Everett J; Tan, Jeffrey S; Burns, Lee J

    2011-11-01

    Dogs are one of the most commonly used non-rodent species in toxicology studies and are known to have basal stomach pH ranging from 2 to 7 in the fasted state. Thus absorption and resulting plasma exposure of weakly basic compounds administered as crystalline suspensions to dogs are often variable. LY2157299 is a potent and selective transforming growth factor (TGF)-beta receptor type 1 kinase (TGF-βRI) inhibitor that displayed variable absorption in early dog studies. This molecule is a weakly basic Biopharmaceutics Classification System (BCS)Class II compound, and depends on the rate and extent of dissolution to drive oral absorption. An artificial stomach and duodenum (ASD) dissolution model was utilized to evaluate potential effect of gastric pH on the absorption of suspension and buffered solution formulations. GastroPlus™ was also employed to predict the magnitude of gastric pH changes on LY2157299 absorption. The ASD experiments demonstrated that administration of a buffered acidic solution could improve the potential for absorption by normalizing gastric pH and enabling supersaturation in the duodenum. GastroPlus™ modeling suggested that direct modulation of gastric pH could lead to marked changes in bioavailability. Pharmacokinetic experiments were conducted in dogs to evaluate the effect of gastric pH modification on plasma exposure. The data were qualitatively consistent with the predictions. Copyright © 2011 Wiley-Liss, Inc.

  2. Results from SAGE II

    International Nuclear Information System (INIS)

    Nico, J.S.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66 -13 +18 (stat) -7 +5 (sys) SNU. Combined with the SAGE I result of 73 -16 +18 (stat) -7 5 (sys) SNU, the capture rate is 69 -11 +11 (stat) -7 +5 (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models

  3. Evaluation of the Apache II and the oncologic history, as indicative predictions of mortality in the unit of intensive care of the INC September 1996 -December 1997

    International Nuclear Information System (INIS)

    Camargo, David O; Gomez, Clara; Martinez, Teresa

    1999-01-01

    They are multiple the indexes of severity that have been carried out to value the predict and the quality of a patient's life, especially when this it enters to the unit of intensive care (UIC); however, the oncologic patient presents particularities in their mobility, that it supposes a different behavior in the results of the Indexes. Presently work is compared the Apache scale and the oncologic history like morbid mortality as predictors in the UCI. 207 patients were included that entered the UCI between September of 1996 and December of 1997. It was a mortality of 29%, the stay of most of this group of patient smaller than 24 hours or bigger than 8 days. To the entrance, 50% of the patients presented superior averages at 15 in the Apache Scale and at the 48 hours, alone 30.4% continued with this value. The patients with hematologic neoplasia presented superior average at 15 in 87%, with a mortality of 63.3% with average between 15 and 24 to the entrance, the risk of dying was 9.8 times but that with inferior average. In the hematologic patient, the risk of dying was 5.7 times but regarding the solid tumors. The system but altered it was the breathing one, with an increase in the risk of dying from 2,8 times for each increment utility in the scale. Contrary to described in the literature, the oncologic diagnoses and the neoplasia statistic they didn't influence in the mortality of the patients

  4. IMMUNE REGULATING ES-PRODUCTS IN PARASITIC NEMATODES

    DEFF Research Database (Denmark)

    Bahlool, Qusay Zuhair Mohammad; Buchmann, Kurt; Kania, Per Walter

    work elucidates the effect of ES substances on the fish immune system by measuring immune gene expression in spleen and liver of rainbow trout (Oncorhynchus mykiss) injected intraperitoneally with ES products isolated from A. simplex third stage larvae. The overall gene expression profile of exposed...... fish showed a generalized down-regulation of the immune genes tested, suggesting a role of ES proteins in minimizing the immune reaction of rainbow trout against invading nematodes. We also tested the enzymatic activity of the ES proteins and found that lipase, esterase lipase, valine and cysteine...... arylamidases, naphthol-AS-BI-phosphohydrolase and a-galactosidase activities were present in the ES solution. This type of hydrolytic enzyme activity may play a role in nematode penetration of host tissue. Based on the notion that A. simplex ES-proteins may have an immune-depressive effect, it could also...

  5. iDESWEB: Usabilidad: qué es

    OpenAIRE

    Luján Mora, Sergio

    2012-01-01

    Qué es la usabilidad, definiciones en ISO 9241 (usuario, objetivo, contexto) e ISO/IEC 9126 (funcionalidad, fiabilidad, usabilidad, eficiencia, mantenibilidad, portabilidad), definición de Jakob Nielsen: "La usabilidad es un atributo de calidad que mide lo fácil que son de usar los interfaces de usuario", componentes de la usabilidad: facilidad de aprendizaje, eficiencia, memorabilidad, errores, satisfacción. Sitio web del curso: http://idesweb.es/

  6. Penetapan Strategi Bisnis pada PT. Pabrik Es Siantar, Pematangsiantar

    OpenAIRE

    Pakpahan, Vovi Novita

    2015-01-01

    This research aims to identify the types of strategies used dan analyze the internal environment PT. Pabrik Es Siantar related strenghts and weaknesses and the external environment related opportunities and threats to determine the right strategy and the way it is applied in PT. Pabrik Es Siantar in the face of competition. The type of strategy adopted PT. Pabrik Es Siantar classified as a defensive strategy. The input stage of business strategy include matrix EFE,IFE and CPM. The total ...

  7. Comparison between two-dimensional and three-dimensional quantitative coronary angiography for the prediction of functional severity in true bifurcation lesions: Insights from the randomized DK-CRUSH II, III, and IV trials.

    Science.gov (United States)

    Zhang, Yao-Jun; Zhu, Hao; Shi, Shun-Yi; Muramatsu, Takashi; Pan, Dao-Rong; Ye, Fei; Zhang, Jun-Jie; Tian, Nai-Liang; Bourantas, Christos V; Chen, Shao-Liang

    2016-03-01

    This study investigated the diagnostic accuracy of three-dimensional quantitative coronary angiography (3D-QCA) compared with conventional 2D-QCA for predicting functional severity assessed by fractional flow reserve (FFR) for true bifurcation lesions. Based on pooled data from the randomized DK-CRUSH II, III, and IV trials, we evaluated the patients with true bifurcation lesions who underwent coronary angiography together with functional evaluations using FFR in both the main vessel and the side branch. Off-line 2D- and 3D-QCA analyses were conducted using dedicated bifurcation QCA analysis software. Measurements of minimum lumen diameter (MLD), percentage diameter stenosis (% DS), and minimum lumen area (MLA) were compared between 2D- and 3D-QCA, and we evaluated their predictive values of functionally significant FFR. Ninety patients were eligible for enrollment in the present study. In the main vessel, MLA measured by 3D-QCA was the most accurate predictor of FFR <0.75 (C statistic 0.85, P < 0.001), while MLD measured by 2D-QCA was a similarly accurate predictor (C statistic 0.85, P < 0.001). In the side branch, the best metrics for predicting FFR <0.75 were % DS measured by 2D-QCA with a C statistic value of 0.91 (P < 0.001) and MLA measured by 3D-QCA with a C statistic value of 0.81 (P < 0.001). However, both 2D- and 3D-QCA metrics exhibited low accuracies for predicting FFR <0.75 in intermediate bifurcation lesions. 3D-QCA analysis for true bifurcation lesions did not improve the predictive accuracy of functionally significant FFR compared with 2D-QCA analysis. In lesions with intermediate stenosis, the diagnostic performance of both 2D- and 3D-QCA-derived measurements in differentiating functional severity is limited. © 2016 Wiley Periodicals, Inc.

  8. Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker

    Directory of Open Access Journals (Sweden)

    Lee Se-Hoon

    2008-05-01

    Full Text Available Abstract Background The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU, folinic acid and oxaliplatin (modified FOLFOX-6 in patients with advanced gastric cancer (AGC, as first-line palliative combination chemotherapy. We also analyzed the predictive or prognostic value of germline polymorphisms of candidate genes associated with 5-FU and oxaliplatin. Methods Seventy-three patients were administered a 2 hour infusion of oxaliplatin (100 mg/m2 and folinic acid (100 mg/m2 followed by a 46 hour continuous infusion of 5-FU (2,400 mg/m2. Genomic DNA from the patients' peripheral blood mononuclear cells was extracted. Ten polymorphisms within five genes were investigated including TS, GSTP, ERCC, XPD and XRCC. Results The overall response rate (RR was 43.8%. Median time to progression (TTP and overall survival (OS were 6.0 months and 12.6 months, respectively. Toxicities were generally tolerable and manageable. The RR was significantly higher in patients with a 6-bp deletion homozygote (-6 bp/-6 bp in TS-3'UTR (55.0% vs. 30.3% in +6 bp/+6 bp or +6 bp/-6 bp, p = 0.034, and C/A or A/A in XPD156 (52.0% vs. 26.1% in C/C, p = 0.038. The -6 bp/-6 bp in TS-3'UTR was significantly associated with a prolonged TTP and OS. In a multivariate analysis, the 6-bp deletion in TS-3'UTR was identified as an independent prognostic marker of TTP (hazard ratio = 0.561, p = 0.032. Conclusion Modified FOLFOX-6 chemotherapy appears to be active and well tolerated as first line chemotherapy in AGC patients. The 6-bp deletion in TS-3'UTR might be a candidate to select patients who are likely to benefit from 5-FU based modified FOLFOX-6 in future large scale trial.

  9. Earth System Documentation (ES-DOC) Preparation for CMIP6

    Science.gov (United States)

    Denvil, S.; Murphy, S.; Greenslade, M. A.; Lawrence, B.; Guilyardi, E.; Pascoe, C.; Treshanksy, A.; Elkington, M.; Hibling, E.; Hassell, D.

    2015-12-01

    During the course of 2015 the Earth System Documentation (ES-DOC) project began its preparations for CMIP6 (Coupled Model Inter-comparison Project 6) by further extending the ES-DOC tooling ecosystem in support of Earth System Model (ESM) documentation creation, search, viewing & comparison. The ES-DOC online questionnaire, the ES-DOC desktop notebook, and the ES-DOC python toolkit will serve as multiple complementary pathways to generating CMIP6 documentation. It is envisaged that institutes will leverage these tools at different points of the CMIP6 lifecycle. Institutes will be particularly interested to know that the documentation burden will be either streamlined or completely automated.As all the tools are tightly integrated with the ES-DOC web-service, institutes can be confident that the latency between documentation creation & publishing will be reduced to a minimum. Published documents will be viewable with the online ES-DOC Viewer (accessible via citable URL's). Model inter-comparison scenarios will be supported using the ES-DOC online Comparator tool. The Comparator is being extended to:• Support comparison of both Model descriptions & Simulation runs;• Greatly streamline the effort involved in compiling official tables.The entire ES-DOC ecosystem is open source and built upon open standards such as the Common Information Model (CIM) (versions 1 and 2).

  10. Buscando Hallaras. Que Bonito Es Leer, II. Libro II. Cuaderno de Ejercicios (Looking You Will Find. How Nice Reading Is, II. Book II. Workbook).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    Designed for bilingual Spanish-English supplemental reading instruction for second grade students, this workbook is intended to be used with the reader of the same title. There is also a teacher's guide. The workbook provides about five pages of reinforcing exercises for each of the eight stories in the reader. The exercises are in the form of…

  11. Buscando Hallaras. Que Bonito Es Leer, II. Libro II. Libro de Lectura (Looking You Will Find. How Nice Reading Is, II. Book II. Reading Book).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    The Spanish reader, which has an accompanying workbook and teacher's guide, is the second in a series of readers designed for second grade supplementary Spanish reading instruction. The book contains eight stories, each about fifteen pages long. The first four have cultural themes and the last four, animal themes. There are black and white…

  12. Buscando Hallaras. Que Bonito Es Leer, II. Libro II. Guia Para el Maestro (Looking You Will Find. How Nice Reading Is, II. Book II. Teacher's Guide).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    The teacher's manual, written in Spanish, is a detailed guide for using the reader and workbook of the same title. Taken together, the three books comprise the second level of a series of supplementary materials to teach reading in Spanish to second grade students. The teacher's guide contains an introduction explaining the series in its entirety,…

  13. Terrestrial birds living on marine environments: does dietary composition of Cinclodes nigrofumosus (Passeriformes: Furnariidae predict their osmotic load? Aves terrestres viviendo en ambientes marinos: ¿es la composición dietaria de Cinclodes nigrofumosus (Passeriformes: Furnariidae un buen predictor de su carga osmótica?

    Directory of Open Access Journals (Sweden)

    PABLO SABAT

    2003-06-01

    Full Text Available Feeding on saline marine foods may be especially challenging for passerine birds that lack functional salt glands and have a limited ability to concentrate urine. To reduce the salt load imposed by consumption of marine food these birds may select food with low salt contents and/or increase their intake of freshwater. The genus Cinclodes is particular among passerines because it includes species that inhabit both inland and maritime shores. We analyzed the diet of Cinclodes nigrofumosus and explored the possible relationships between dietary composition and salt load at mesic and arid coastal sites of Chile. From a biogeographical perspective, we hypothesized that freshwater availability is critical to the relationship between diet composition and osmotic load of C. nigrofumosus. Our analysis of prey abundance and distribution indicated that the diet of C. nigrofumosus is composed mainly by marine prey, in spite of the availability of terrestrial insects at both sites. Stomach content osmolality was higher in the arid site, but it was not correlated with prey type, which suggests that Cinclodes nigrofumosus avoid a high osmotic load, drinking fresh water when available. Thus physiological constraints are modulating niche breath of CinclodesAlimentarse de presas marinas representa un desafío para aves paseriformes que no poseen glándula de la sal y tienen una habilidad limitada para concentrar orina. Para reducir la carga osmótica asociada al consumo de presas marinas estas aves podrían optar por incluir presas con bajas concentraciones salinas en su dieta y/o aumentar la ingestión de agua dulce. El género Cinclodes es particular entre los paseriformes debido a que incluye especies que habitan riberas de lagos, ríos y costas marinas. Analizamos la dieta de Cinclodes nigrofumosus y exploramos la posible relación entre la composición de ésta y la carga salina en dos sitios costeros de Chile, uno mésico y otro árido. En este estudio

  14. RSR II- "The Quadrature of Cern"

    CERN Multimedia

    Lehmann,P

    1984-01-01

    Suite à la parution du livre choc, où certaines accusations sont lancées contre le Cern, la Radio Suisse Romande II interroge deux des quatre auteurs de ce livre, les physiciens Pierre Lehmann et André Gsponer qui donneront des détails sur le livre qu'ils sont publié (Editions d'En-Bas)

  15. Prediction of the moments in advection-diffusion lattice Boltzmann method. II. Attenuation of the boundary layers via double-Λ bounce-back flux scheme

    Science.gov (United States)

    Ginzburg, Irina

    2017-01-01

    Impact of the unphysical tangential advective-diffusion constraint of the bounce-back (BB) reflection on the impermeable solid surface is examined for the first four moments of concentration. Despite the number of recent improvements for the Neumann condition in the lattice Boltzmann method-advection-diffusion equation, the BB rule remains the only known local mass-conserving no-flux condition suitable for staircase porous geometry. We examine the closure relation of the BB rule in straight channel and cylindrical capillary analytically, and show that it excites the Knudsen-type boundary layers in the nonequilibrium solution for full-weight equilibrium stencil. Although the d2Q5 and d3Q7 coordinate schemes are sufficient for the modeling of isotropic diffusion, the full-weight stencils are appealing for their advanced stability, isotropy, anisotropy and anti-numerical-diffusion ability. The boundary layers are not covered by the Chapman-Enskog expansion around the expected equilibrium, but they accommodate the Chapman-Enskog expansion in the bulk with the closure relation of the bounce-back rule. We show that the induced boundary layers introduce first-order errors in two primary transport properties, namely, mean velocity (first moment) and molecular diffusion coefficient (second moment). As a side effect, the Taylor-dispersion coefficient (second moment), skewness (third moment), and kurtosis (fourth moment) deviate from their physical values and predictions of the fourth-order Chapman-Enskog analysis, even though the kurtosis error in pure diffusion does not depend on grid resolution. In two- and three-dimensional grid-aligned channels and open-tubular conduits, the errors of velocity and diffusion are proportional to the diagonal weight values of the corresponding equilibrium terms. The d2Q5 and d3Q7 schemes do not suffer from this deficiency in grid-aligned geometries but they cannot avoid it if the boundaries are not parallel to the coordinate lines. In order

  16. MicroRNA modulation induced by AICA ribonucleotide in J1 mouse ES cells.

    Directory of Open Access Journals (Sweden)

    Xiaoyan Shi

    Full Text Available ES cells can propagate indefinitely, maintain self-renewal, and differentiate into almost any cell type of the body. These properties make them valuable in the research of embryonic development, regenerative medicine, and organ transplantation. MicroRNAs (miRNAs are considered to have essential functions in the maintenance and differentiation of embryonic stem cells (ES cells. It was reported that, strong external stimuli, such as a transient low-pH and hypoxia stress, were conducive to the formation of induced pluripotent stem cells (iPS cells. AICA ribonucleotide (AICAR is an AMP-activated protein kinase activator, which can let cells in the state of energy stress. We have demonstrated that AICAR can maintain the pluripotency of J1 mouse ES cells through modulating protein expression in our previous research, but its effects on ES cell miRNA expression remain unknown. In this study, we conducted small RNA high-throughput sequencing to investigate AICAR influence on J1 mouse ES cells by comparing the miRNA expression patterns of the AICAR-treated cells and those without treatment. The result showed that AICAR can significantly modulate the expression of multiple miRNAs, including those have crucial functions in ES cell development. Some differentially expressed miRNAs were selected and confirmed by real-time PCR. For the differently expressed miRNAs identified, further study was conducted regarding the pluripotency and differentiation associated miRNAs with their targets. Moreover, miR-134 was significantly down-regulated after AICAR treatment, and this was suggested to be directly associated with the up-regulated pluripotency markers, Nanog and Sox2. Lastly, Myc was significantly down-regulated after AICAR treatment; therefore, we predicted miRNAs that may target Myc and identified that AICAR induced up-regulation of miR-34a, 34b, and 34c can repress Myc expression in J1 mouse ES cells. Taken together, our study provide a new mechanism for

  17. Placa bacteriana dentária em cães

    OpenAIRE

    Eurides,Duvaldo; Gonçalves,Gentil Ferreira; Mazzanti,Alexandre; Buso,Antônio Mário

    1996-01-01

    Com objetivo de avaliar a incidência de placa bacteriana dentária, foram utilizados 30 cães, sem raça definida, distribuídos em três grupos iguais, de acordo com a faixa etária, sendo o grupo I de 0 a 2 anos, o grupo II de 3 a 5 anos e o grupo III acima de 6 anos. Os animais foram submetidos a anestesia geral e sobre os dentes foi aplicado cloreto de metilrosanilina, para evidenciar acúmulos bacterianos. As placas encontravam-se distribuídas em 80,99% no grupo I, 71,45% no grupo II e 83,96% n...

  18. A study on an efficient prediction of welding deformation for T-joint laser welding of sandwich panel Part II: Proposal of a method to use shell element model

    Directory of Open Access Journals (Sweden)

    Jae Woong Kim

    2014-06-01

    Full Text Available I-core sandwich panel that has been used more widely is assembled using high power CO2 laser welding. Kim et al. (2013 proposed a circular cone type heat source model for the T-joint laser welding between face plate and core. It can cover the negative defocus which is commonly adopted in T-joint laser welding to provide deeper penetration. In part I, a volumetric heat source model is proposed and it is verified thorough a comparison of melting zone on the cross section with experiment results. The proposed model can be used for heat transfer analysis and thermal elasto-plastic analysis to predict welding deformation that occurs during laser welding. In terms of computational time, since the thermal elasto-plastic analysis using 3D solid elements is quite time consuming, shell element model with multi-layers have been employed instead. However, the conventional layered approach is not appropriate for the application of heat load at T-Joint. This paper, Part II, suggests a new method to arrange different number of layers for face plate and core in order to impose heat load only to the face plate.

  19. A study on an efficient prediction of welding deformation for T-joint laser welding of sandwich panel Part II : Proposal of a method to use shell element model

    Directory of Open Access Journals (Sweden)

    Kim Jae Woong

    2014-06-01

    Full Text Available I-core sandwich panel that has been used more widely is assembled using high power CO₂laser welding. Kim et al. (2013 proposed a circular cone type heat source model for the T-joint laser welding between face plate and core. It can cover the negative defocus which is commonly adopted in T-joint laser welding to provide deeper penetration. In part I, a volumetric heat source model is proposed and it is verified thorough a comparison of melting zone on the cross section with experiment results. The proposed model can be used for heat transfer analysis and thermal elasto-plastic analysis to predict welding deformation that occurs during laser welding. In terms of computational time, since the thermal elasto-plastic analysis using 3D solid elements is quite time consuming, shell element model with multi-layers have been employed instead. However, the conventional layered approach is not appropriate for the application of heat load at T-Joint. This paper, Part II, suggests a new method to arrange different number of layers for face plate and core in order to impose heat load only to the face plate.

  20. Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.

    Science.gov (United States)

    Criscitiello, Michael F; Ohta, Yuko; Graham, Matthew D; Eubanks, Jeannine O; Chen, Patricia L; Flajnik, Martin F

    2012-03-01

    The invariant chain (Ii) is the critical third chain required for the MHC class II heterodimer to be properly guided through the cell, loaded with peptide, and expressed on the surface of antigen presenting cells. Here, we report the isolation of the nurse shark Ii gene, and the comparative analysis of Ii splice variants, expression, genomic organization, predicted structure, and function throughout vertebrate evolution. Alternative splicing to yield Ii with and without the putative protease-protective, thyroglobulin-like domain is as ancient as the MHC-based adaptive immune system, as our analyses in shark and lizard further show conservation of this mechanism in all vertebrate classes except bony fish. Remarkable coordinate expression of Ii and class II was found in shark tissues. Conserved Ii residues and cathepsin L orthologs suggest their long co-evolution in the antigen presentation pathway, and genomic analyses suggest 450 million years of conserved Ii exon/intron structure. Other than an extended linker preceding the thyroglobulin-like domain in cartilaginous fish, the Ii gene and protein are predicted to have largely similar physiology from shark to man. Duplicated Ii genes found only in teleosts appear to have become sub-functionalized, as one form is predicted to play the same role as that mediated by Ii mRNA alternative splicing in all other vertebrate classes. No Ii homologs or potential ancestors of any of the functional Ii domains were found in the jawless fish or lower chordates. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. Exact scattering solutions in an energy sudden (ES) representation

    International Nuclear Information System (INIS)

    Chang, B.; Eno, L.; Rabitz, H.

    1983-01-01

    In this paper, we lay down the theoretical foundations for computing exact scattering wave functions in a reference frame which moves in unison with the system internal coordinates. In this frame the (internal) coordinates appear to be fixed and its adoption leads very naturally (in zeroth order) to the energy sudden (ES) approximation [and the related infinite order sudden (IOS) method]. For this reason we call the new representation for describing the exact dynamics of a many channel scattering problem, the ES representation. Exact scattering solutions are derived in both time dependent and time independent frameworks for the representation and many interesting results in these frames are established. It is shown, e.g., that in a time dependent frame the usual Schroedinger propagator factorizes into internal Hamiltonian, ES, and energy correcting propagators. We also show that in a time independent frame the full Green's functions can be similarly factorized. Another important feature of the new representation is that it forms a firm foundation for seeking corrections to the ES approximation. Thus, for example, the singularity which arises in conventional perturbative expansions of the full Green's functions (with the ES Green's function as the zeroth order solution) is avoided in the ES representation. Finally, a number of both time independent and time dependent ES correction schemes are suggested

  2. ANALISIS KADAR SIKLAMAT PADA ES KRIM DI KOTA BANJARBARU

    Directory of Open Access Journals (Sweden)

    Nurlailah Nurlailah

    2017-07-01

    Full Text Available Pemanis merupakan salah satu komponen yang sering ditambahkan dalam bahan makanan. Pemanis buatan yang banyak beredar di masyarakat adalah siklamat. Konsumsi siklamat yang melebihi dosis akan mengakibatkan kanker kandung kemih. Selain itu akan menyebabkan tumor paru, hati, dan limfa. Tujuan penelitian ini adalah untuk mengetahui adanya siklamat dalam es krim yang melebihi ambang batas yang dipersyaratkan. Jenis penelitian ini adalah survey deskriptif. Sampel penelitian adalah es krim produksi rumah tangga dari seluruh pedagang es krim di Banjarbaru utara yaitu dengan jumlah 11 pedagang es krim. Variabel dalam penelitian ini adalah kadar siklamat yang terdapat dalam es krim. Hasil penelitian menunjukkan dari 11 sampel es krim yang diperiksa, 9 sampel mengandung siklamat dengan kadar tertinggi 7,37 g/kg sebagai asam siklamat. Kesimpulan penelitian ini adalah es krim yang mengandung siklamat ditemukan sebanyak 82% (9 sampel, sedangkan 18% (2 sampel lainnya negatif, dari 9 sampel yang positif mengandung siklamat, 89% tidak memenuhi syarat PERMENKES Nomor 208 tahun 1985 yaitu melebihi 2 gr/kg sebagai asam siklamat. Perlu dilakukan pemeriksaan yang lebih spesifik untuk analisis kadar siklamat dengan metode lain seperti Kromatografi Cair Kinerja Tinggi (KCKT

  3. Solar photocatalytic removal of Cu(II), Ni(II), Zn(II) and Pb(II): Speciation modeling of metal-citric acid complexes

    International Nuclear Information System (INIS)

    Kabra, Kavita; Chaudhary, Rubina; Sawhney, R.L.

    2008-01-01

    The present study is targeted on solar photocatalytic removal of metal ions from wastewater. Photoreductive deposition and dark adsorption of metal ions Cu(II), Ni(II), Pb(II) and Zn(II), using solar energy irradiated TiO 2 , has been investigated. Citric acid has been used as a hole scavenger. Modeling of metal species has been performed and speciation is used as a tool for discussing the photodeposition trends. Ninety-seven percent reductive deposition was obtained for copper. The deposition values of other metals were significantly low [nickel (36.4%), zinc (22.2%) and lead (41.4%)], indicating that the photocatalytic treatment process, using solar energy, was more suitable for wastewater containing Cu(II) ions. In absence of citric acid, the decreasing order deposition was Cu(II) > Ni(II) > Pb(II) > Zn(II), which proves the theoretical thermodynamic predictions about the metals

  4. Diccionarios monolingües de ELE vs. diccionarios normativos

    Directory of Open Access Journals (Sweden)

    Villarrubia Zúñiga, Marisol

    2013-11-01

    Full Text Available En el artículo analizamos diferentes lemas en el Diccionario Salamanca y los comparamos con los de varios diccionarios normativos del español, como por ejemplo, el DRAE. Nuestro propósito es ver cómo están construidos para evidenciar, cuál de estos es más útil para un estudiante que está aprendiendo el español como segunda lengua y por qué lo es.

  5. Knowledge-based geographic information systems on the Macintosh computer: a component of the GypsES project

    Science.gov (United States)

    Gregory Elmes; Thomas Millette; Charles B. Yuill

    1991-01-01

    GypsES, a decision-support and expert system for the management of Gypsy Moth addresses five related research problems in a modular, computer-based project. The modules are hazard rating, monitoring, prediction, treatment decision and treatment implementation. One common component is a geographic information system designed to function intelligently. We refer to this...

  6. Pb II

    African Journals Online (AJOL)

    Windows User

    This investigation describes the use of non-living biomass of Aspergillus caespitosus for removal of ... Pb(II) production has exceeded 3.5 million tons per year. It has been used in the ... This biomass was selected after screening a wide range of microbes. .... prolonged, which proved better biopolymer in metal uptake (Gadd ...

  7. Tratamento do câncer de esôfago: ensaio clinico controlado

    Directory of Open Access Journals (Sweden)

    Antonio Pedro Mirra

    Full Text Available Realização de ensaio clínico controlado em câncer de esôfago, com uma casuística de 65 casos, no Hospital A.C. Camargo, no período de 1986 a 1990. O ensaio clínico controlado estudou três grupos terapêuticos: grupo I - cirurgia exclusiva (20 casos; grupo 2 - cirurgia + radioterapia pós-operatória (27 casos; grupo 3 - quimioterapia pré-operatória + cirurgia + radioterapia e quimioterapia pós-operatória (18 casos. O tempo cirúrgico foi único, com ressecção ampla do esôfago, utilizando-se como vias de acesso, preferentemente, a transpleural para os tumores localizados no terço médio do esôfago e a transmediastinal para o terço inferior e segmento abdominal. A retirada dos gânglios linfáticos regionais fez parte deste tempo cirúrgico, bem como a técnica de plastia padronizada com o estômago, com anastomose extratorácica cervical e posição do estômago no mediastino posterior. A radioterapia foi aplicada no leito esofágico, com dose total de 4.500 a 5.000 cGY em cinco sessões semanais. Foram utilizadas as drogas cisplatina (80 mg/m², vincristina (1,5 mg/m² e bleomicina (10mg/m² na quimioterapia pré e pós-operatórias. A sobrevida de cinco anos, segundo os grupos terapêuticos, foi de: grupo I - 61,9% , grupo 2 - 52,6 % e grupo 3 - 68,7%. Esta sobrevida, segundo o estadiamento clínico, foi de: EC I+II A - 52,0% e EC II B + III- 45,5%. Esses resultados estatisticamente não foram significativos. Os índices de sobrevida de cinco anos para os grupos terapêuticos 1 e 2 variaram de 40,4 a 60,6% quando os EC foram I + II A; para os demais EC não houve sobrevida de cinco anos. Para uma melhor avaliação, a inclusão de maior número de casos em pesquisas desse tipo poderia ser obtida pela participação de vários centros de tratamento do câncer de esôfago.

  8. L'innovation au service d'économies du savoir caractérisées par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'innovation au service d'économies du savoir caractérisées par l'inclusion en Asie - phase II. Learning Initiatives for Network Economies in Asia (LIRNEasia) cherche à cerner les obstacles institutionnels à l'utilisation efficace des technologies de l'information et de la communication (TIC) pour améliorer les conditions de ...

  9. "Aarøes Strejfkorps - en dansk specialenhed i 1864"

    DEFF Research Database (Denmark)

    Papousek, Simon

    2014-01-01

    Boganmeldelse af genudgivelse af to artikler tidligere bragt i Militært Tidsskrift i slutningen af 1800-tallet, omhandlende oprettelsen, operationerne og historien om den danske specialenhed "Aarøes Strejfkorps" under Anden Slesvgiske Krig...

  10. ¿Qué es Indoor airPLUS?

    Science.gov (United States)

    El Programa Interior de airPLUS es una asociación entre EPA, los constructores, raters, las utilidades, y organizaciones sanitarias e interiores ambientales de mejorar aire interior en nuevas casas casas verdes.

  11. Patient Satisfaction At The Muhimbili National Hospital In Dar Es ...

    African Journals Online (AJOL)

    Patient Satisfaction At The Muhimbili National Hospital In Dar Es Salaam, Tanzania. ... staffpatient relationship ethos, in which the patient is a viewed as a customer. Keywords: patient satisfaction, reform, Muhimbili National Hospital, referral ...

  12. Alderisio_Meri_vs_ES_MS_vs_MSD

    Data.gov (United States)

    U.S. Environmental Protection Agency — Stain Comparison Meri vs. ES. This dataset is associated with the following publication: Alderiswio, K., L. Villegas, M. Ware, L. McDonald, L. Xiao, and E. Villegas....

  13. La costumbre no es fuente del Derecho Procesal

    OpenAIRE

    Gascón Inchausti, Fernando

    1999-01-01

    Comentario a la Sentencia del Tribunal Supremo de 28 de abril de 1998. Se analiza el valor jurídico que cabe atribuir a ciertos usos forenses, dado que la costumbre no es fuente del Derecho Procesal.

  14. Home Performance with Energy Star (HPwES) Program Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-01-01

    This report summarizes the Department’s review of comments received on the HPwES v2 proposal and presents a multi-year action plan to both address Department goals and incorporate industry feedback.

  15. Final Technical Report: Electronic Structure Workshop (ES13)

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Shiwei [College of William and Mary, Williamsburg, VA (United States)

    2015-02-26

    The 25th Annual Workshop on Recent Developments in Electronic Structure Methods (ES2013) was successfully held at the College of William & Mary in Williamsburg VA on June 11-14, 2013. The workshop website is at http://es13.wm.edu/ , which contains updated information on the workshop and a permanent archive of the scientific contents. DOE's continued support has been instrumental to the success of the workshop.

  16. El Buen Ordeño es muy Importante

    Directory of Open Access Journals (Sweden)

    Blackman Charles

    1947-06-01

    Full Text Available El ordeño es uno de los mayores trabajos de las fincas lecheras y es también uno de los más importantes. La forma en que se ordeña las vacas determina en gran parte la calidad de la leche e influye además sobre la cantidad de leche producida. Las vacas lecheras deben ser ordeñadas dos veces al día, a intervalos iguales.

  17. Neural induction from ES cells portrays default commitment but instructive maturation.

    Directory of Open Access Journals (Sweden)

    Nibedita Lenka

    Full Text Available The neural induction has remained a debatable issue pertaining to whether it is a mere default process or it involves precise instructive cues. We have chosen the embryonic stem (ES cell model to address this issue. In a devised monoculture strategy, the cell-cell interaction availed through optimum cell plating density could define the niche for the attainment of efficient in vitro neurogenesis from the ES cells. The medium plating density was found ideal in generating optimum number of progenitors and also yielded about 80% mature neurons in a serum free culture set up barring any exogenous inducers. We could also demarcate and quantify the neural stem cells/progenitors among the heterogeneous cell population of differentiating ES cells using nestin intron II driven EGFP expression as a tool. The one week post-plating was determined to be the critical time window for optimum neural progenitor generation from ES cells that helped us further in purifying these cells and in demonstrating their proliferation and multipotent differentiation potential. Seeding cells at varying densities, we could decipher an interesting paradoxical scenario that interlinked both commitment and maturation with the initial plating density having a vital influence on neuronal maturation but not specification and the secretory factors were apparently playing a key role during this process. Thus it was comprehended that, the neural specification was a default process independent of exogenous factors and cellular interaction. Conversely, a defined number of cells at the specification stage itself seemed critical to provide an auto-/paracrine means of signaling threshold for the maturation process to materialize.

  18. Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation.

    Directory of Open Access Journals (Sweden)

    Constance Ciaudo

    2009-08-01

    Full Text Available Embryonic stem (ES cells are pluripotent cells derived from the inner cell mass of the mammalian blastocyst. Cellular differentiation entails loss of pluripotency and gain of lineage-specific characteristics. However, the molecular controls that govern the differentiation process remain poorly understood. We have characterized small RNA expression profiles in differentiating ES cells as a model for early mammalian development. High-throughput 454 pyro-sequencing was performed on 19-30 nt RNAs isolated from undifferentiated male and female ES cells, as well as day 2 and 5 differentiating derivatives. A discrete subset of microRNAs (miRNAs largely dominated the small RNA repertoire, and the dynamics of their accumulation could be readily used to discriminate pluripotency from early differentiation events. Unsupervised partitioning around meloids (PAM analysis revealed that differentiating ES cell miRNAs can be divided into three expression clusters with highly contrasted accumulation patterns. PAM analysis afforded an unprecedented level of definition in the temporal fluctuations of individual members of several miRNA genomic clusters. Notably, this unravelled highly complex post-transcriptional regulations of the key pluripotency miR-290 locus, and helped identify miR-293 as a clear outlier within this cluster. Accordingly, the miR-293 seed sequence and its predicted cellular targets differed drastically from those of the other abundant cluster members, suggesting that previous conclusions drawn from whole miR-290 over-expression need to be reconsidered. Our analysis in ES cells also uncovered a striking male-specific enrichment of the miR-302 family, which share the same seed sequence with most miR-290 family members. Accordingly, a miR-302 representative was strongly enriched in embryonic germ cells derived from primordial germ cells of male but not female mouse embryos. Identifying the chromatin remodelling and E2F-dependent transcription

  19. Placa bacteriana dentária em cães Dental bacterial plaque in dogs

    Directory of Open Access Journals (Sweden)

    Duvaldo Eurides

    1996-12-01

    Full Text Available Com objetivo de avaliar a incidência de placa bacteriana dentária, foram utilizados 30 cães, sem raça definida, distribuídos em três grupos iguais, de acordo com a faixa etária, sendo o grupo I de 0 a 2 anos, o grupo II de 3 a 5 anos e o grupo III acima de 6 anos. Os animais foram submetidos a anestesia geral e sobre os dentes foi aplicado cloreto de metilrosanilina, para evidenciar acúmulos bacterianos. As placas encontravam-se distribuídas em 80,99% no grupo I, 71,45% no grupo II e 83,96% no grupo III. Os grupos dentários foram considerados separadamente, apresentando índices de 64,84% nos dentes incisivos, 84,80% nos caninos, 87,23% nos pré-molares e 78,34% nos molares. Nos três grupos de cães observou-se índices semelhantes de placa bacteriana nos diferentes grupos dentários. Os animais do grupo II e o grupo de dentes incisivos apresentaram menores índices de placa bacteriana.To avaliate the incidence of bacterial plaque 30 mogreal dogs were utilizated, distributed among three equal groups. According to age, group I was composed of 0 to 2 years-old dogs, group II was 3 to 5 years-old, and group III over 6 years-old. The animals underwent a general anesthesia and metilrosanilin cloret was applied over the tooth, to evidence the bacterial mass. The plaques were distributed to 80.99% in group I, 71.42% in group II and 83.96% in group III. The dental groups were considerated apart, showing index of 64.84% on the incisar tooth, 84.80% on the canine tooth, 87.23% on the premolar tooth, and 78.34% on the molar tooth. At the dogs groups, similar Índex of bacterial plaque were observed on the diffèrent dental groups. The dogs from group II and the incisive tooth group showed minar bacterial plaque index.

  20. Predicting scholars' scientific impact.

    Directory of Open Access Journals (Sweden)

    Amin Mazloumian

    Full Text Available We tested the underlying assumption that citation counts are reliable predictors of future success, analyzing complete citation data on the careers of ~150,000 scientists. Our results show that i among all citation indicators, the annual citations at the time of prediction is the best predictor of future citations, ii future citations of a scientist's published papers can be predicted accurately (r(2 = 0.80 for a 1-year prediction, P<0.001 but iii future citations of future work are hardly predictable.

  1. 'El 'vos' es el dialecto que inventamos nosotros, la forma correcta es el 'tú''

    Directory of Open Access Journals (Sweden)

    Ane Christiansen

    2014-06-01

    Full Text Available Nicaragua es un país con un nivel de escolarización relativamente bajo y el contexto material y social en las escuelas hace que la enseñanza de la lengua materna esté dominada por métodos de memorización y ejercicios de gramática del tipo “rellenar espacios”. Las formas de tratamiento escritas que se utilizan en contextos pedagógicos son únicamente el tú y el usted, a pesar de ser Nicaragua una zona voseante. El presente artículo pretenderá mostrar, a través de referencias a estudios sobre las formas de tratamiento en Nicaragua, análisis del uso de los tratamientos en la escritura, ejemplos de entrevistas de actitudes lingüísticas y de análisis de documentos pedagógicos, que hay una discrepancia entre la norma escrita y la norma hablada en cuanto a las formas de tratamiento tú y vos en Nicaragua. Esta discrepancia se puede explicar con las creencias en torno a las diferentes formas de tratamiento, pero también al revés: el uso contradictorio de parte de las autoridades educativas influirá en las creencias del pueblo en general acerca de las formas de tratamiento y así crece un clima de inseguridad de la corrección de su propia habla. En última instancia tal contradicción puede ser un obstáculo para la enseñanza de la lengua materna y el prestigio lingüístico del habla local.

  2. Substances bioactives élaborées par des cyanobactéries isolées de ...

    African Journals Online (AJOL)

    Les substances extracellulaires produites par les cyanobactéries étudiées ont aussi une activité antibactérienne vis-à-vis de M. luteus, Bacillus subtilis, Serratia marcescens, B. cereus, Escherichia coli 0128B12 et Staphylococcus aureus. Le biotest souris a permis de montrer que certaines cyanobactéries étudiées ...

  3. PENGGUNAAN RUMPUT LAUT SEBAGAI STABILIZER ES KRIM SUSU SARI KEDELAI

    Directory of Open Access Journals (Sweden)

    Aviani Violisa

    2013-07-01

    Full Text Available The used of seaweed as stabilizing agent on the soymilk-based ice cream. The purpose of this study is to investigate the chemical, physical and organoleptic characteristics of soymilk-based ice cream, in which seaweed is used as a stabilizing agent. The results of this study showed that soymilk-based ice cream with seaweed at the concen­tration of 0.5% have the highest fat and protein contents, viscosity, and the longest melt-down rate. Ice cream with the concentration of 0.4% had the highest solid level, while the concentration of 0.3% produced the highest overrun of ice cream. For the hedonic-quality parameter, ice cream with the concentration of 0.5% had the highest of aroma score and soft texture, while at the concentra­tion of 0.3% had the highest sweet flavor. For the hedonic parameter, ice cream with the con­cen­tra­tion of 0.4% had the highest aroma and sweet flavor preference. Tujuan penelitian ini adalah mengetahui sifat kimia, fisik, dan organoleptik es krim susu sari kedelai dengan rumput laut sebagai stabilizer. Hasil penelitian me­nunjukkan bahwa es krim susu sari kedelai dengan stabilizer rumput laut konsentrasi 0,5% memiliki kadar lemak tertinggi, kadar protein tertinggi, viskositas tertinggi, dan waktu meleleh paling lama. Es krim padatan tertinggi diperoleh dari stabilizer kon­sentrasi 0,4%. Overrun tertinggi terdapat pada es krim dengan stabilizer konsentrasi 0,3%. Hasil uji mutu hedonik, es krim dengan stabilizer konsentrasi 0,5% menghasil­kan aroma tertinggi dan tekstur paling lembut, sedangkan es krim dengan stabilizer 0,3% menghasilkan rasa termanis. Hasil uji hedonik, es krim dengan stabilizer kon­sen­trasi 0,4% memiliki nilai kesukaan aroma tertinggi dan kesukaan rasa tertinggi.

  4. Desenvolvimento motor e cognitivo de bebês de mães adolescentes e adultas: estudo longitudinal

    Directory of Open Access Journals (Sweden)

    Luana Silva de Borba

    2015-07-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2015v17n4p438   Este estudo teve como objetivos investigar em bebês de mães adolescentes e adultas: (1 os fatores de risco para o desenvolvimento infantil; (2 as mudanças cognitivas e motoras ao longo de quatro meses, (3 as correlações entre o desenvolvimento motor e cognitivo ao longo de quatro meses. Estudo longitudinal com 40 bebês, 20 nascidos de mães adolescentes e 20 de mães adultas, provenientes dos municípios de Porto Alegre e Butiá, no Rio Grande do Sul, Brasil. Foram realizadas três avaliações do desenvolvimento motor e cognitivo, utilizando a Alberta Motor Infant Scale (AIMS e Bayley Scale of Infant Development II. Na postura supina da AIMS, observou-se diferença significativa entre os grupos na terceira avaliação. Os bebês das mães adolescentes apresentaram escores mais baixos em relação aos bebês de mães adultas. Os escores motores de cada postura da AIMS e o escore total AIMS apresentaram diferença significativa ao longo do tempo em geral e em cada grupo. O escore mental bruto da Bayley-II também apresentou diferença significativa ao longo do tempo em geral e em cada grupo. Observou-se associação positiva, forte e significativa entre os escores totais da AIMS e Bayley em todos os três momentos de avaliação no grupo de bebês de mães adolescentes e adultas. Pode-se concluir que bebês de mães adolescentes apresentaram-se piores na postura supina em relação aos bebês de mães adultas. Os desenvolvimentos motor e cognitivo se associaram significativamente em ambos os grupos ao longo do tempo.

  5. Small Diameter Bomb Increment II (SDB II)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-439 Small Diameter Bomb Increment II (SDB II) As of FY 2017 President’s Budget Defense... Bomb Increment II (SDB II) DoD Component Air Force Joint Participants Department of the Navy Responsible Office References SAR Baseline (Production...Mission and Description Small Diameter Bomb Increment II (SDB II) is a joint interest United States Air Force (USAF) and Department of the Navy

  6. Predictive role of HER2/neu, topoisomerase-II-alpha, and tissue inhibitor of metalloproteinases (TIMP-1) for response to adjuvant taxane-based chemotherapy in patients with intermediate-risk breast cancer: results from the WSG-AGO EC-Doc trial.

    Science.gov (United States)

    Erber, Ramona; Gluz, Oleg; Brünner, Nils; Kreipe, Hans Heinrich; Pelz, Enrico; Kates, Ronald; Bartels, Annette; Huober, Jens; Mohrmann, Svjetlana; Moustafa, Zehra; Liedtke, Cornelia; Möbus, Volker; Augustin, Doris; Thomssen, Christoph; Jänicke, Fritz; Kiechle, Marion; Kuhn, Walther; Nitz, Ulrike; Harbeck, Nadia; Hartmann, Arndt

    2015-04-01

    Taxane-anthracycline-based adjuvant chemotherapy is standard of care in patients with node-positive breast cancer (BC) but is also associated with severe side effects and significant costs. It is yet unclear, which biomarkers would predict benefit from taxanes and/or general chemoresistance. In this study, we investigate a large cohort of patients with intermediate-risk BC treated within the WSG EC-DOC Trial for the predictive impact of topoisomerase-II-alpha, HER2/neu, and TIMP-1. Tumor tissue was available in a representative cohort of 772 cases of the WSG EC-DOC Trial collective which compared 4xEC-4xDoc versus 6xCEF/CMF. In addition to hormone receptor status and Ki-67, HER2/neu+ and topoisomerase-II-alpha status using fluorescence in situ hybridisation (FISH) and immunohistochemistry, TIMP-1 using immunohistochemistry, and aneuploidy of chromosome 17 using FISH were evaluated and correlated with outcome and taxane benefit. There was significant superiority of EC-Doc over CEF regarding 5-year DFS (90 vs. 80 %, respectively, p = 0.006) particularly in patient subgroups defined by HR+, HER2/neu+, high proliferation (i.e., Ki-67 ≥ 20 %), patient age >50 years old and normal chromosome 17 status, high TIMP-1 and low topoisomerase-II-alpha protein expression. Significant prognostic factors in multivariate analysis were EC-Doc therapy (HR = 0.61; 95 %CI 0.38-0.986), age Doc vs. CEF) and high topoisomerase-II-alpha protein expression (HR = 0.427; 95 %CI 0.203-0.900) in multivariate interaction analysis. Despite of univariate predictive effect of HER2/neu status among other factors only topoisomerase-II-alpha protein expression was associated with significant benefit from EC-Doc compared to CEF by multivariate interaction analysis.

  7. EL CONCURSO DE ACREEDORES ES COSA DE HOMBRES

    OpenAIRE

    Navarro-Sánchez, Roberto Carlos

    2015-01-01

    En los últimos años es incuestionable el incremento en el número de empresas creadas o dirigidas por mujeres en España, cifra que actualmente está en el entorno del 23- 35% del global de empresas (Guzmán, Rodríguez, 2008). Este dato es muy significativo, si bien aún es muy bajo en comparación con otros países, sobre todo si tenemos en cuenta que las mujeres lo tienen mucho más difícil a la hora de montar sus empresas debido a las barreras de género existentes, provocadas por los roles asig...

  8. ES-RBE Event sequence reliability Benchmark exercise

    International Nuclear Information System (INIS)

    Poucet, A.E.J.

    1991-01-01

    The event Sequence Reliability Benchmark Exercise (ES-RBE) can be considered as a logical extension of the other three Reliability Benchmark Exercices : the RBE on Systems Analysis, the RBE on Common Cause Failures and the RBE on Human Factors. The latter, constituting Activity No. 1, was concluded by the end of 1987. The ES-RBE covered the techniques that are currently used for analysing and quantifying sequences of events starting from an initiating event to various plant damage states, including analysis of various system failures and/or successes, human intervention failure and/or success and dependencies between systems. By this way, one of the scopes of the ES-RBE was to integrate the experiences gained in the previous exercises

  9. ¿Es posible la transformación docente?

    Directory of Open Access Journals (Sweden)

    Agustín de la Herrán Gascón

    2016-05-01

    Full Text Available Se presenta un ensayo en torno a dos cuestiones fundamentales: si es posible la transformación docente y si tiene sentido una formación orientada más allá del conocimiento y la efectividad. Se construyó tras una acción formativa (Herrán, 2015b que tuvo lugar el 20 de junio de 2015 en la Universidad Nacional Autónoma de México (UNAM, con directivos de escuelas y facultades de Informática y Computación. En aquella ocasión, la ponencia tenía por título: “¿Es posible la transformación docente? Más allá de la necesidad de efectividad en la gestión y de la apropiación del conocimiento”. El objetivo del ensayo es ahondar aún más en la formación pedagógica del profesorado universitario como un reto no sólo irresuelto, sino insuficiente y mal planteado, y generar controversia científica en este sentido. La metodología es dialéctica, hermenéutica, dialógica y destructiva de convicciones y certezas, obviamente con una última finalidad constructiva. Se recurre a una experiencia didáctica como hilo conductor explicativo. Las conclusiones apuntan a dos cuestiones: que la transformación docente sólo es posible o superficialmente o en la profundidad de la formación, que incluye planos y constructos inéditos o excluidos de la formación ordinaria del profesor universitario, y que si la formación no trasciende el conocimiento y la efectividad, no es tal.

  10. Zfp206 regulates ES cell gene expression and differentiation.

    Science.gov (United States)

    Zhang, Wen; Walker, Emily; Tamplin, Owen J; Rossant, Janet; Stanford, William L; Hughes, Timothy R

    2006-01-01

    Understanding transcriptional regulation in early developmental stages is fundamental to understanding mammalian development and embryonic stem (ES) cell properties. Expression surveys suggest that the putative SCAN-Zinc finger transcription factor Zfp206 is expressed specifically in ES cells [Zhang,W., Morris,Q.D., Chang,R., Shai,O., Bakowski,M.A., Mitsakakis,N., Mohammad,N., Robinson,M.D., Zirngibl,R., Somogyi,E. et al., (2004) J. Biol., 3, 21; Brandenberger,R., Wei,H., Zhang,S., Lei,S., Murage,J., Fisk,G.J., Li,Y., Xu,C., Fang,R., Guegler,K. et al., (2004) Nat. Biotechnol., 22, 707-716]. Here, we confirm this observation, and we show that ZFP206 expression decreases rapidly upon differentiation of cultured mouse ES cells, and during development of mouse embryos. We find that there are at least six isoforms of the ZFP206 transcript, the longest being predominant. Overexpression and depletion experiments show that Zfp206 promotes formation of undifferentiated ES cell clones, and positively regulates abundance of a very small set of transcripts whose expression is also specific to ES cells and the two- to four-cell stages of preimplantation embryos. This set includes members of the Zscan4, Thoc4, Tcstv1 and eIF-1A gene families, none of which have been functionally characterized in vivo but whose members include apparent transcription factors, RNA-binding proteins and translation factors. Together, these data indicate that Zfp206 is a regulator of ES cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators.

  11. Adolescent Girls with illegally Induced Abortion in Dar es Salaam

    DEFF Research Database (Denmark)

    Rasch, V; Silberschmidt, Margrethe; Mchumvu, Y

    2000-01-01

    that gave them the right to seek family planning services and in practice these services are not being provided. There is a need for youth-friendly family planning services and to make abortion safe and legal, in order to reduce unwanted pregnancies and abortion-related complications and deaths among......This article reports on a study of induced abortion among adolescent girls in Dar es Salaam, Tanzania, who were admitted to a district hospital in Dar es Salaam because of an illegally induced abortion in 1997. In the quantitative part of the study, 197 teenage girls (aged 14-19) were asked...

  12. High transfer cross sections from reactions with 254Es

    International Nuclear Information System (INIS)

    Schaedel, M.; Bruechle, W.; Bruegger, M.; Gaeggeler, H.; Moody, J.; Schardt, D.; Suemmerer, K.; Hulet, E.K.; Dougan, A.D.; Dougan, R.J.; Landrum, J.H.; Lougheed, R.W.; Wild, J.F.; O'Kelly, G.D.

    1985-08-01

    We report radiochemically determined cross sections for the heaviest known actinides produced in transfer reactions of 101 MeV 16 O, 98 MeV 18 O and 127 MeV 22 Ne with 254 Es as a target. A comparison with data for similar transfers from 248 Cm targets is made. Transfer cross sections are extrapolated for the production of unknown, neutron-rich isotopes of elements 101 through 105, and the unique potential of 254 Es as a target to make these exotic nuclei accessible is demonstrated. (orig.)

  13. La equidad no es mera declamación

    OpenAIRE

    Villamayor, Claudia

    2009-01-01

    Es de preocupación para las mujeres que participan de movimientos sociales y que trabajan en una lucha por sus derechos, que la futura Ley de comunicación audiovisual contemple en su redacción un enfoque de género. Impunemente, es muy común observar actitudes editoriales donde reina la homofobia, la xenofobia o la discriminación por discapacidades, por condiciones etáreas o por condición de credos. Una Ley de Servicios de Comunicación Audiovisual tiene que contemplar que los medios ...

  14. Specification Section 01065S ES&H for Service Contracts

    Energy Technology Data Exchange (ETDEWEB)

    Kirsch, Greg C. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2014-07-01

    Section Includes: Requirements and guidelines in performance of work concerning protection of environment and property, and the safety and health of Contractors, Sandia National Laboratories (SNL) and Department of Energy (DOE) employees, visitors to SNL, and members of the public. This Section is applicable only to Service Contracts that do not involve construction or construction-like activities. Construction and construction-like activities are covered by Section 01065, Environment, Safety and Health (ES&H) for Construction Contracts. The entire ES&H program shall focus on safe-by-design intent, understanding the technical basis for the work, identifying and controlling energy sources, unacceptable consequences, risk assessments, and positive verification.

  15. Detection of Planetary Emission from the Exoplanet TrES-2 Using Spitzer/IRAC

    Science.gov (United States)

    Donovan, Francis T.; Charbonneau, David; Harrington, Joseph; Madhusudhan, N.; Seager, Sara; Deming, Drake; Knutson, Heather A.

    2010-01-01

    We present here the results of our observations of TrES-2 using the Infrared Array Camera on Spitzer. We monitored this transiting system during two secondary eclipses, when the planetary emission is blocked by the star. The resulting decrease in flux is 0.127% +/- 0.021%, 0.230% +/- 0.024%, 0.199% +/- 0.054%, and 0.359% +/- 0.060% at 3.6 microns, 4.5 microns, 5.8 microns, and 8.0 microns, respectively. We show that three of these flux contrasts are well fit by a blackbody spectrum with T(sub eff) = 1500 K, as well as by a more detailed model spectrum of a planetary atmosphere. The observed planet-to-star flux ratios in all four lRAC channels can be explained by models with and without a thermal inversion in the atmosphere of TrES-2, although with different atmospheric chemistry. Based on the assumption of thermochemical equilibrium, the chemical composition of the inversion model seems more plausible, making it a more favorable scenario. TrES-2 also falls in the category of highly irradiated planets which have been theoretically predicted to exhibit thermal inversions. However, more observations at infrared and visible wavelengths would be needed to confirm a thermal inversion in this system. Furthermore, we find that the times of the secondary eclipses are consistent with previously published times of transit and the expectation from a circular orbit. This implies that TrES-2 most likely has a circular orbit, and thus does not obtain additional thermal energy from tidal dissipation of a non-zero orbital eccentricity, a proposed explanation for the large radius of this planet. Key words: eclipses - infrared: stars - planetary systems - stars: individual (OSC 03549-02811) - techniques: photometric

  16. BeII** revisited

    International Nuclear Information System (INIS)

    Fischer, C.F.

    1982-01-01

    Doubly excited 1s2snl and 1s2pnl quartet states of BeII** are readily populated in beam-foil experiments and line-rich spectra have been obtained covering 600 to 5500 A wavelength range. In spite of several theoretical calculations a substantial number of observed lines have not been identified. The quartet system in BeII is an intersting one from a theoretical point of view. Three electron systems are simple enough that a fairly high level of accuracy is attainable without the calculations becoming horrendous. The important correlation effects are between the outer two electrons and, to a good approximation, the three-electrons system may be treated as a two-electron system outside a 1s-core. The multi-configuration Hartree-Fock (MCHF) method has been used successfully in a number of studies. Programs are under development that take into account the non-orthogonality of orbitals in the initial and final state, and allow for some non-orthogonal orbitals in a wavefunction expansion. LS dependent relativistic effects are also included. A study of BeII** was undertaken to evaluate the MCHF techniques being developed and to assit in the identification of observed lines. Most of the earlier calculations concentrated on the lower-lying levels. In this work particular attention was given to the more highly-excited states, though calculations for lower-lying states had to be repeated in order to predict life-times

  17. Textos sobre Sostenibilidad II

    Directory of Open Access Journals (Sweden)

    Ciudades para un futuro más sostenible http://habitat.aq.upm.es

    2004-12-01

    This issue assembles a selection of articles publicly available on the website Ciudades para un Futuro más Sostenible (CF+S: http://habitat.aq.upm.es. This selection was originally used as a printed companion guide to the public lecture series on ‘‘Sustainability in the Architecture and Urban Project’’, held on March 2004 and organized by the Madrid School of Architecture within the Initiative for a more Sustainable Architecture and Urbanism (IAU+S. The compilation an overall vision on sustainability presents to average audience. The basic criterion to select these articles was therefore a pedagogical one, including those simpler and clearer papers dealing with all main topics in CF+S. However, due to space limitations, many excellent articles available on the website are unfortunately not included within this selection. CF+S was created in 1996 as a partnership between the Spanish Ministry of Works and Madrid School of Architecture. The objective was to translate into Spanish and publish the experiences selected at the International Award for Best Practices in Improving the Living Environment, organized by United Nations after the Istanbul Conference on Human Settlements (Habitat II. CF+S aims to gather documents concerning any kind of actions and experiences both on the territory and the city actually improving people’s living conditions according to the sustainability concept in its strongest sense. It also offers papers, reports and theoretical reflections on the state of and the possible alternatives to urban development nowadays.

  18. Feeding Dar es Salaam: a symbiotic food system perspective

    NARCIS (Netherlands)

    Wegerif, Marc C.A.

    2017-01-01

    This thesis is a sociological analysis of the agri-food system that feeds most of the over four and a half million residents of the fast-growing city of Dar es Salaam in Tanzania. It is based on qualitative research that has generated a picture of the food system that supplies the important foods

  19. SAChES: Scalable Adaptive Chain-Ensemble Sampling.

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ray, Jaideep [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Ebeida, Mohamed Salah [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Huang, Maoyi [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hou, Zhangshuan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bao, Jie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ren, Huiying [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-08-01

    We present the development of a parallel Markov Chain Monte Carlo (MCMC) method called SAChES, Scalable Adaptive Chain-Ensemble Sampling. This capability is targed to Bayesian calibration of com- putationally expensive simulation models. SAChES involves a hybrid of two methods: Differential Evo- lution Monte Carlo followed by Adaptive Metropolis. Both methods involve parallel chains. Differential evolution allows one to explore high-dimensional parameter spaces using loosely coupled (i.e., largely asynchronous) chains. Loose coupling allows the use of large chain ensembles, with far more chains than the number of parameters to explore. This reduces per-chain sampling burden, enables high-dimensional inversions and the use of computationally expensive forward models. The large number of chains can also ameliorate the impact of silent-errors, which may affect only a few chains. The chain ensemble can also be sampled to provide an initial condition when an aberrant chain is re-spawned. Adaptive Metropolis takes the best points from the differential evolution and efficiently hones in on the poste- rior density. The multitude of chains in SAChES is leveraged to (1) enable efficient exploration of the parameter space; and (2) ensure robustness to silent errors which may be unavoidable in extreme-scale computational platforms of the future. This report outlines SAChES, describes four papers that are the result of the project, and discusses some additional results.

  20. vARIATIONS MENSUELLES DURANT TROIS ANNÉES DU ...

    African Journals Online (AJOL)

    , Université .... ont reçu une alimentation à base de pâturage de. Panicum maximum avec ... Variations mensuelles durant trois années du nombre de spermatozoïdes par éjaculat et des paramètres de spermocytogramme du sperme de bélier ...

  1. Coastal Marine Pollution in Dar es Salaam (Tanzania) relative to ...

    African Journals Online (AJOL)

    Pollution surveys were undertaken during 2007 and 2008 in the coastal marine environment of Dar es Salaam and the remote Ras Dege Creek. The objective was to determine the levels of microbial contamination, heavy metals and persistent organic pollutants and compare these with the recommended environmental ...

  2. Invitation à soumettre des idées

    International Development Research Centre (IDRC) Digital Library (Canada)

    fdieudonne

    et de politiques en vue de favoriser des systèmes alimentaires plus sains et de prévenir les maladies non ... ultra-transformées, qui sont pauvres sur le plan nutritionnel. ... aux prix, et restrictions en matière de marketing visant à augmenter la ...

  3. Side relvaliigi rollist kaitseväes / Villem Sedrik

    Index Scriptorium Estoniae

    Sedrik, Villem

    2007-01-01

    Autor annab ülevaate siderelvaliigi arengust kaitseväes ning rõhutab lahinguolukorras erinevate võitlevate partnerite infosüsteemide koostöö ja infovahetuse tähtsust tänapäeval. Vt. ka Sõdur nr. 2 lk. 12-15. Vahur Parve. Kiirpilk sidepidamise ajalukku

  4. ES-cell derived hematopoietic cells induce transplantation tolerance.

    Directory of Open Access Journals (Sweden)

    Sabrina Bonde

    Full Text Available BACKGROUND: Bone marrow cells induce stable mixed chimerism under appropriate conditioning of the host, mediating the induction of transplantation tolerance. However, their strong immunogenicity precludes routine use in clinical transplantation due to the need for harsh preconditioning and the requirement for toxic immunosuppression to prevent rejection and graft-versus-host disease. Alternatively, embryonic stem (ES cells have emerged as a potential source of less immunogenic hematopoietic progenitor cells (HPCs. Up till now, however, it has been difficult to generate stable hematopoietic cells from ES cells. METHODOLOGY/PRINCIPAL FINDINGS: Here, we derived CD45(+ HPCs from HOXB4-transduced ES cells and showed that they poorly express MHC antigens. This property allowed their long-term engraftment in sublethally irradiated recipients across MHC barriers without the need for immunosuppressive agents. Although donor cells declined in peripheral blood over 2 months, low level chimerism was maintained in the bone marrow of these mice over 100 days. More importantly, chimeric animals were protected from rejection of donor-type cardiac allografts. CONCLUSIONS: Our data show, for the first time, the efficacy of ES-derived CD45(+ HPCs to engraft in allogenic recipients without the use of immunosuppressive agents, there by protecting cardiac allografts from rejection.

  5. Aloe; Beyond use as cosmetics | Pili | Dar Es Salaam Medical ...

    African Journals Online (AJOL)

    Dar Es Salaam Medical Students' Journal. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 15, No 1 (2008) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Aloe; Beyond use as cosmetics. K Pili. Abstract.

  6. Dar es Salaam City and Challenges in Solid Waste Management ...

    African Journals Online (AJOL)

    The focus of this paper is on challenges facing solid waste management in. Manzese and Sinza wards, in Dar es Salaam city. In this paper different ways of generating, disposing waste and the associated problems are surveyed. About 102 people were interviewed. Different methods were employed in data collection which ...

  7. Engineering geological mapping of Dar es Salaam city, Tanzania ...

    African Journals Online (AJOL)

    Two basic maps were prepared, namely, geomorphological and geological map depicts the spatial extent of the Neogene geological formations. Three distinct sandstone terraces could be distinguished in Dar es Salaam region at 0-15 m and 30 – 40 m above sea level. The terraces comprised sandstones fringed by coral ...

  8. Electrical stimulation (ES) in the management of sexual pain disorders.

    Science.gov (United States)

    Nappi, Rossella E; Ferdeghini, Francesea; Abbiati, Ileana; Vercesi, Claudia; Farina, Claudio; Polatti, Franco

    2003-01-01

    We performed an open study to investigate the use of electrical stimulation (ES) on the vestibular area and vaginal introitus in women with sexual pain disorders. We recruited 29 women (age range 20-45 years) from among the patients at our Reproductive Psychobiology Unit to participate in the present study. They each experienced vestibular pain, inducing dyspareunia and vaginism. We performed ES with an ECL43400 apparatus (Elite, EssediEsse srl, Milan, Italy) once a week for 10 weeks. To evaluate the muscular activity of the perineal floor and sexual function, we employed the same apparatus with a vaginal probe for recording myoelectrical activity (muV), we employed a VAS scale for evaluating pain, and we administered the Female Sexual Function Index (FSFI; Rosen et al., 2000) before and after the study protocol. We analyzed data by parametric and nonparametric comparisons and correlations, as appropriate. Our major findings were as follows: (a) the contractile ability of pelvic floor muscles (p vaginism went back to coital activity; (d) FSFI pain score and the current intensity tolerated, both before (R = .59; p < 0.006) and at the end (R = .53; p < 0.02) of the stimulation protocol, positively correlated. ES may be effective in the management of sexual pain disorders. Further controlled studies are necessary to standardize stimulation protocols according to the severity of pain and to better clarify the long-term clinical effects of ES.

  9. ¿Es la asistencia sexual un derecho?

    Directory of Open Access Journals (Sweden)

    Rafael De Asís Roig

    2017-12-01

    Full Text Available En este trabajo voy a reflexionar sobre la cuestión de la asistencia sexual y su posible configuración como derecho. La contestación a la pregunta sobre si la asistencia sexual es un derecho puede variar dependiendo del marco en el que nos desenvolvamos. Así, podemos estar hablando desde un marco estrictamente jurídico, desde un marco ético, o desde un marco a caballo entre ambos como es el de los derechos humanos. A partir de aquí, la pregunta sobre si la asistencia sexual es un derecho dependerá de la pregunta sobre qué es la asistencia sexual. La justificación de la asistencia sexual en relación con personas que no pueden realizar actividad sexual sobre su propio cuerpo puede encontrar una justificación ética de la mano de la teoría de las necesidades o de la mano de las Actividades Básicas de la Vida Diaria, e igualmente puede formar parte de los derechos sexuales o del derecho a elegir una forma de vida.

  10. Heavy Metals and Organic Pollutants in Sediments of Dar es ...

    African Journals Online (AJOL)

    The Florida criteria (MacDonald 1993) for assessment of pollution of tropical marine sediments was adopted in oredr to evaluate the extent of pollution in Dar es Salaam harbour sediments. The Florida criteria is one of the established references for sediment quality assessment. Heavy metals that had concentrations above ...

  11. Knowledge, Attitude and Practice of Commercial Drivers in Dar es ...

    African Journals Online (AJOL)

    Purpose: The objective of this study was, first, to assess the knowledge, attitude and practice of commercial drivers in Dar es Salaam with regard to medicines that impair driving, and second, to evaluate the adequacy of antihistamine label information. Methods: Drivers were interviewed using a questionnaire after obtaining ...

  12. Community violence in Dar es Salaam, Tanzania: A mixed methods ...

    African Journals Online (AJOL)

    Most homicide deaths in Dar es Salaam, Tanzania (DSM) are a result of violence arising from within the community. This type of violence is commonly called, by perpetrators and victims, “mob justice”. Unilateral non-state collective violence can take four forms: lynching, vigilantism, rioting, and terrorism. The purpose of this ...

  13. Accessibility, Congestion and Travel Delays in Dar es Salaam

    DEFF Research Database (Denmark)

    Melbye, Dea Christine; Møller-Jensen, Lasse; Andreasen, Manja Hoppe

    2015-01-01

    on to present a review of research into travel speed levels and congestion in Dar es Salaam. A set of city-wide maps of accessibility and delay levels are constructed based on available speed data and road network data obtained from the OpenStreetMap project and the findings are discussed with respect...

  14. OpenGL ES 3.0 cookbook

    CERN Document Server

    Singh, Parminder

    2015-01-01

    If you are new to OpenGL ES or have some experience in 3D graphics, then this book will be extremely helpful in raising your expertise level from a novice to professional. The book implements more than 90 recipes to solve everyday challenges, helping you transition from a beginner to a professional.

  15. Radiochemical search for neutron-rich isotopes of nielsbohrium in the (16)O + (254)Es reaction

    International Nuclear Information System (INIS)

    Schaedel, M.; Jaeger, E.; Bruechle, W.; Suemmerer, K.; Hulet, E.K.; Wild, J.F.; Lougheed, R.W.; Dougan, R.J.; Moody, K.J.

    1994-09-01

    We have used on-line gas chromatography to search for new isotopes of element 107 near the deformed sub-shell at N = 162 and Z = 108. Enhanced nuclear stability is predicted for this region. 254g Es was irradiated with 16 O at barrier energies to minimize the fusion hindrance in the entrance channel and to reduce the excitation energy of the compound nucleus to a minimum value. For half-lives between roughly two seconds and two minutes no signal for a positive identification of a new isotope of element 107 was detected. Consequently, only an upper cross-section limit of a few nanobarns was obtained. While this cross-section limit was too high to probe the influence of the predicted enhanced nuclear ground-state stability on the survival probability in the fission/evaporation competition, a very large cross-section enhancement would have been detectable. (orig.)

  16. Towards Predictive Association Theories

    DEFF Research Database (Denmark)

    Kontogeorgis, Georgios; Tsivintzelis, Ioannis; Michelsen, Michael Locht

    2011-01-01

    Association equations of state like SAFT, CPA and NRHB have been previously applied to many complex mixtures. In this work we focus on two of these models, the CPA and the NRHB equations of state and the emphasis is on the analysis of their predictive capabilities for a wide range of applications....... We use the term predictive in two situations: (i) with no use of binary interaction parameters, and (ii) multicomponent calculations using binary interaction parameters based solely on binary data. It is shown that the CPA equation of state can satisfactorily predict CO2–water–glycols–alkanes VLE...

  17. Final report: ES11: The 23rd Annual Workshop on Electronic Structure Methods

    Energy Technology Data Exchange (ETDEWEB)

    Rappe, Andrew M. [Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Chemistry

    2011-08-31

    ES11: the 23rd Annual Workshop on Electronic Structure Methods was held from June 6-9, 2011 at the University of Pennsylvania. The local organizing committee (see Section II) led by PI Andrew M. Rappe supervised the organization of the conference, before, during, and after the meeting itself. The national organizing committee set the technical program of talks, and provided support and advice in various ways. The conference was well-attended (see Section III). An important feature of this conference was a series of panel discussions (see Section IV) to discuss the field of electronic structure and to set new directions. The technical program was of extraordinarily high quality (see Section V). The host institution, the University of Pennsylvania, provided a supportive environment for this meeting (see Section VI).

  18. Expresiones de afecto de madres bilingües, Bilingual mothers' expressions of affect

    Science.gov (United States)

    Shiro, Martha

    2015-01-01

    En la interacción de 10 madres bilingües con sus hijos de 30 meses se analiza la expresión de afectividad en L1 y en L2. Se identificaron las expresiones de emoción, volición y actitud epistémica en 30 interacciones espontáneas: i. 10 madres (español L1) hablando en L1; ii. 10 madres (español L1) hablando en inglés L2; y iii. 10 madres (inglés L1) hablando en L1. Los resultados sugieren que los usos de L2 difieren de los de L1 (inglés o español): la expresión de volición y actitud epistémica se asemeja al inglés L1, mientras que la expresión de las emociones se acerca al español L1. Estos hallazgos permiten explicar los usos del lenguaje expresivo de los bilingües y ayudan a determinar sus efectos en el desarrollo del lenguaje PMID:25844004

  19. [Cross-cultural adaptation to the European Portuguese of the questionnaire "Patient Knowledge about their Medications" (CPM-ES-ES)].

    Science.gov (United States)

    Salmerón Rubio, Joaquín; Iglésias-Ferreira, Paula; García Delgado, Pilar; Mateus-Santos, Henrique; Martínez-Martínez, Fernando

    2013-12-01

    The scope of this work is to conduct the cross-cultural adaptation from Spanish to European Portuguese of a questionnaire to measure the degree of "Patient Knowledge about their Medications" (CPM-ES-ES). A method based on six steps was applied: 1. Translation into Portuguese, 2. Elaboration of the first consensus version in Portuguese; 3.Back-translation into Spanish; 4. Elaboration of the second consensus version (cultural equivalency); 5. Conducting the pre-test; 6. Evaluation of the overall results. A cross-culturally adapted questionnaire in European Portuguese that measures the degree of "Patient Knowledge about their Medications" is proposed. The pre-test confirmation obtained 100% agreement with the corrected version of the second consensus version after pre-testing. The methodology selected made it possible to cross-culturally adapt the Spanish version of the CPM-ES-ES questionnaire to the Portuguese version. Further studies should demonstrate the equivalence of the psychometric properties of the cross-cultural translation into Portuguese with the original version.

  20. First results from SAGE II

    International Nuclear Information System (INIS)

    Abdurashitov, J.N.; Faizov, E.L.; Gavrin, V.N.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76 -18 +21 (stat) -7 +5 (sys) SNU. combined with the SAGE I result, the capture rate is 74 -12 +13 (stat) -7 +5 (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models

  1. First results from SAGE II

    International Nuclear Information System (INIS)

    Aburashitov, J.N.; Faizov, E.L.; Gavrin, V.N.; Gusev, A.O.; Kalikhov, A.V.; Knodel, T.V.; Knyshenko, I.I.; Kornoukhov, V.N.; Mirmov, I.N.; Pshukov, A.M.; Shalagin, A.M.; Shikhin, A.A.; Timofeyev, P.V.; Veretenkin, E.P.; Vermul, V.M.; Zatsepin, G.T.; Bowles, T.J.; Nico, J.S.; Teasdale, W.A.; Wark, D.L.; Wilkerson, J.F.; Cleveland, B.T.; Daily, T.; Davis, R. Jr.; Lande, K.; Lee, C.K.; Wildenhain, P.W.; Elliott, S.R.; Cherry, M.L.

    1995-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76 +21 -18 (stat) +5 -7 (sys) SNU. Combined with the SAGE I result, the capture rate is 74 +13 -12 (stat) +5 -7 (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models. copyright 1995 American Institute of Physics

  2. Quadratic prediction of factor scores

    NARCIS (Netherlands)

    Wansbeek, T

    1999-01-01

    Factor scores are naturally predicted by means of their conditional expectation given the indicators y. Under normality this expectation is linear in y but in general it is an unknown function of y. II is discussed that under nonnormality factor scores can be more precisely predicted by a quadratic

  3. Usefulness of the admission electrocardiogram to predict long-term outcomes after non-ST-elevation acute coronary syndrome (from the FRISC II, ICTUS, and RITA-3 [FIR] Trials)

    DEFF Research Database (Denmark)

    Damman, Peter; Holmvang, Lene; Tijssen, Jan G P

    2012-01-01

    Instability in Coronary Artery Disease (FRISC II), Invasive Versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS), and Randomized Intervention Trial of Unstable Angina 3 (RITA-3) patient-pooled database, 5,420 patients with NSTE-ACS with qualitative ECG data, of whom 2,901 had quantitative data...... the addition of quantitative characteristics to a model including qualitative characteristics. In conclusion, in the FRISC II, ICTUS, and RITA-3 NSTE-ACS patient-pooled data set, admission ECG characteristics provided long-term prognostic value for cardiovascular death or myocardial infarction. Quantitative...

  4. ¿El beber café es salud?

    Directory of Open Access Journals (Sweden)

    María Del Rosario Alvarez-Ramirez

    2005-12-01

    Full Text Available El café es una bebida universal responsable de levantar a muchos cada mañana. El uso continuo de bebidas con cafeína también produce efectos a largo plazo. Los cuales aumentan su riesgo a 120% si bebe diariamente 6 o más tazas de café. La cafeína también puede causar úlceras en el estómago, producir alergias, insomnios, irritabilidad, palpitaciones, fiebre y otros síntomas como: aumentar los niveles de noradrenalina (neurotransmisor que produce un estado de alerta. Por las mismas razones que el café aumenta el estado de alerta y estimula el rendimiento mental, una taza de café es una forma ideal de comenzar el día.

  5. Les crises soudanaises des années 80

    OpenAIRE

    Ahmed, Medani M.; al-Shazali, Salah al-Din; al-Shazali, Salah al-Din; al-Shazali, Salah al-Din; al-Shazali, Salah al-Din; Al-Tom, Abdulahi Osman; Babiker, Mustafa; Babiker, Mustafa; Blin, Louis; Conte, Édouard; Elmekki, Abdelgalil M.; Gore, Paul W.; Hamid, Mohammed Beshir; Ireton, François; Jacquemond, Richard

    2008-01-01

    Ce dossier est constitué, dans sa quasi-totalité, de contributions de chercheurs et universitaires soudanais proposant une analyse de certains des problèmes cruciaux que leur pays a connus depuis le début des années 80. Les articles qui le composent correspondent aux communications qui devaient initialement être présentées lors d’un colloque portant sur le même thème, prévu à Paris pour décembre 1991 et qui n'a pu avoir lieu du fait de l’impossibilité où se trouvaient certains de ses particip...

  6. An adaptive ES with a ranking based constraint handling strategy

    Directory of Open Access Journals (Sweden)

    Kusakci Ali Osman

    2014-01-01

    Full Text Available To solve a constrained optimization problem, equality constraints can be used to eliminate a problem variable. If it is not feasible, the relations imposed implicitly by the constraints can still be exploited. Most conventional constraint handling methods in Evolutionary Algorithms (EAs do not consider the correlations between problem variables imposed by the constraints. This paper relies on the idea that a proper search operator, which captures mentioned implicit correlations, can improve performance of evolutionary constrained optimization algorithms. To realize this, an Evolution Strategy (ES along with a simplified Covariance Matrix Adaptation (CMA based mutation operator is used with a ranking based constraint-handling method. The proposed algorithm is tested on 13 benchmark problems as well as on a real life design problem. The outperformance of the algorithm is significant when compared with conventional ES-based methods.

  7. Cloning of ES cells and mice by nuclear transfer.

    Science.gov (United States)

    Wakayama, Sayaka; Kishigami, Satoshi; Wakayama, Teruhiko

    2009-01-01

    We have been able to develop a stable nuclear transfer (NT) method in the mouse, in which donor nuclei are directly injected into the oocyte using a piezo-actuated micromanipulator. Although the piezo unit is a complex tool, once mastered it is of great help not only in NT experiments, but also in almost all other forms of micromanipulation. Using this technique, embryonic stem (ntES) cell lines established from somatic cell nuclei can be generated relatively easily from a variety of mouse genotypes and cell types. Such ntES cells can be used not only for experimental models of human therapeutic cloning but also as a means of preserving mouse genomes instead of preserving germ cells. Here, we describe our most recent protocols for mouse cloning.

  8. Coherent structures in the Es layer and neutral middle atmosphere

    Science.gov (United States)

    Mošna, Zbyšek; Knížová, Petra Koucká; Potužníková, Kateřina

    2015-12-01

    The present paper shows results from the summer campaign performed during geomagnetically quiet period from June 1 to August 31, 2009. Within time-series of stratospheric and mesospheric temperatures at pressure levels 10-0.1 hPa, mesospheric winds measured in Collm, Germany, and the sporadic E-layer parameters foEs and hEs measured at the Pruhonice station we detected specific coherent wave-bursts in planetary wave domain. Permanent wave-like activity is observed in all analyzed data sets. However, the number of wave-like structures persistent in large range of height from the stratosphere to lower ionosphere is limited. The only coherent modes that are detected on consequent levels of the atmosphere are those corresponding to eigenmodes of planetary waves.

  9. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_Aqua-FM3_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  10. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CERES:CER_ES9_PFM+FM1_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  11. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_Terra-FM2_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  12. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF ( CER_ES9_Aqua-FM3_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  13. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_PFM+FM1_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  14. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_FM1+FM4_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  15. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_Aqua-FM4_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  16. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_PFM+FM2_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  17. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF ( CER_ES9_Terra-FM1_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-09-30] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  18. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_Aqua-FM4_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  19. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF ( CER_ES9_Aqua-FM4_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  20. CERES ERBE-like Monthly Regional Averages (ES-9) in HDF (CER_ES9_Terra-FM1_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Regional Averages (ES-9) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-9 is also produced for combinations of scanner instruments. All instantaneous shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-8 product for a month are sorted by 2.5-degree spatial regions, by day number, and by the local hour of observation. The mean of the instantaneous fluxes for a given region-day-hour bin is determined and recorded on the ES-9 along with other flux statistics and scene information. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The ES-9 also contains hourly average fluxes for the month and an overall monthly average for each region. These average fluxes are given for both clear-sky and total-sky scenes. The following CERES ES9 data sets are currently available: CER_ES9_FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition1 CER_ES9_PFM+FM1+FM2_Edition2 CER_ES9_PFM+FM1_Edition1 CER_ES9_PFM+FM2_Edition1 CER_ES9_PFM+FM1_Edition2 CER_ES9_PFM+FM2_Edition2 CER_ES9_TRMM-PFM_Edition1 CER_ES9_TRMM-PFM_Edition2 CER_ES9_Terra-FM1_Edition1 CER_ES9_Terra-FM2_Edition1 CER_ES9_FM1+FM2_Edition2 CER_ES9_Terra-FM1_Edition2 CER_ES9_Terra-FM2_Edition2 CER_ES9_Aqua-FM3_Edition1 CER_ES9_Aqua-FM4_Edition1 CER_ES9_FM1+FM2+FM3+FM4_Edition1 CER_ES9_Aqua-FM3_Edition2 CER_ES9_Aqua-FM4_Edition2 CER_ES9_FM1+FM3_Edition2 CER_ES9_FM1+FM4_Edition2 CER_ES9_Aqua-FM3_Edition1-CV CER_ES9_Aqua-FM4_Edition1-CV CER_ES9_Terra-FM1_Edition1-CV CER_ES9_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost

  1. Les mosquées ibadites du Maghreb

    Directory of Open Access Journals (Sweden)

    Virginie Prevost

    2012-07-01

    Full Text Available Les mosquées ibadites du Mzab, de Djerba et du djebel Nafûsa partagent plusieurs caractéristiques communes, la plus importante étant la multiplication des mihrabs et des lieux de prière extérieurs à la salle. Les mosquées mozabites se distinguent plus particulièrement par leur haut minaret de type saharien et par leur respect absolu de deux particularités ibadites, l’absence de minbar et le refus de toute forme de décoration. Quant au djebel Nafûsa et à Djerba, ils présentent des mosquées assez semblables, très modestes et parfois souterraines, dont le minaret, s’il existe, adopte des styles très diversifiés. Certaines salles de prière portent le traditionnel décor géométrique berbère. Les mosquées djerbiennes, dont l’architecture est intrinsèquement liée à l’insularité, sont spécialement intéressantes par leur intégration au système défensif de l’île, par la diversité des décors ajoutés tardivement et surtout par la fréquence du minaret-escalier qui a été conservé au travers des siècles.

  2. Coherent structures in the Es layer and neutral middle atmosphere

    Czech Academy of Sciences Publication Activity Database

    Mošna, Zbyšek; Koucká Knížová, Petra; Potužníková, Kateřina

    136 B, December (2015), s. 155-162 ISSN 1364-6826 R&D Projects: GA ČR(CZ) GA15-24688S; GA ČR(CZ) GAP209/12/2440 Institutional support: RVO:68378289 Keywords : critical frequency foEs * mesospheric temperature * mesospheric winds * planetary waves * Rossby mode * sporadic layer * stratospheric temperature Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 1.463, year: 2015 http://www.sciencedirect.com/science/article/pii/S1364682615001273

  3. What is effective is fair Lo eficaz es justo

    Directory of Open Access Journals (Sweden)

    Le Mouël Jacques

    1997-06-01

    Full Text Available In this text, which comes from Chapter 3 of his book, Jacques Le Mouel completes the philosophical reflection about the entrepreneurial myth of effectiveness founded in the sophism: "What is effective is true. What is true is faie. Therefore, what is effective is fair". The fact that management is elevated to the category of paradigm for the economic model of Western society and the collapse of the economies of the East has led to neglect that, now, we ourselves are the modelo His analysis of the supposed neutrality of science and of the differences between ethics and morality, in the framework of the firm and its relations with society, lead him to conclude that it is not true that what is effective is fair, and that the firm cannot serve as a model for contemporary society, since the end does not justify the means.En este texto, que corresponde al capitulo 3 de su libro, Jaques Le Mouël completa la reflexión filosófica sobre el mito empresarial de la eficacia funadado en el sofisma: "Lo eficaz es verdadero. Lo verdadero es justo. Luego, lo eficaz es justo". El hecho de elevar la administración a la categoría de paradigma del modelo económico de la sociedad occidental y el hundimiento de las economías del Este han llevado a ignorar que, ahora, el modelo somos nosotros mismos. Su análisis de la pretendida neutralidad de la ciencia y las diferencias entre ética y moral, en el marco de la empresa y en sus relaciones con la sociedad, lo lleva a concluir que no es cierto que lo eficaz sea justo y que la empresa no puede servir de modelo a la sociedad contemporánea, pues el fin no justifica los medios.

  4. POLITIQUES ÉCLAIRÉES Des politiques judicieuses favorisent le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La valeur des travaux de recherche que le CRDI subventionne depuis 1970 réside dans les améliorations apportées aux conditions de vie. Ces travaux entraînent des changements dans les lois et les attitudes; par example, ils permettent aux pauvres de se faire entendre, augmentent les ressources financières et rendent ...

  5. Conception de bases de données avec UML

    CERN Document Server

    Roy, Gilles

    2007-01-01

    De l'analyse à la conception, cet ouvrage accorde une importance prédominante au modèle conceptuel de données et propose des règles, des techniques, des astuces et des mises en garde qui doivent guider le modélisateur dans la réalisation d'un bon modèle conceptuel.

  6. A Browning process : The case of Dar es Salaam city

    OpenAIRE

    Mng'ong'o, Othmar Simtali

    2005-01-01

    The study is about how green spaces and structures of Dar es Salaam city, quantitatively and qualitatively, are browning out. It also tries to explore the different reasons behind the browning tendency, and what it means to the function of the city and to the daily form of life of the inhabitants. Finally there is a discussion about how to counteract the tendency by involving the inhabitants in planning procedures following the communicative approach to planning. The main investigations have ...

  7. Optimization of simultaneous electrochemical determination of Cd(II), Pb(II), Cu(II) and Hg(II) at carbon nanotube-modified graphite electrodes.

    Science.gov (United States)

    Pikna, L'ubomír; Heželová, Mária; Kováčová, Zuzana

    2015-01-01

    The health of the environment is worsening every day. Monitoring of potentially toxic elements and remediation of environmental pollution are necessary. Therefore, the research and development of simple, inexpensive, portable and effective sensors is important. Electrochemistry is a useful component of the field of environment monitoring. The present study focuses on evaluating and comparing three types of electrodes (PIGE, PIGE/MWCNT/HNO3 and PIGE/MWCNT/EDTA/HNO3) employed for the simultaneous electrochemical determination of four potentially toxic elements: Cd(II), Pb(II), Cu(II) and Hg(II). Cyclic voltammograms were measured in an acetate buffer. The LOD, LOQ, the standard and relative precisions of the method and a prediction intervals were calculated (according to the technical procedure DIN 32 645) for the three electrodes and for each measured element. The LOD for PIGE/CNT/HNO3 (the electrode with narrowest calculated prediction intervals) was 2.98 × 10(-7) mol L(-1) for Cd(II), 4.83 × 10(-7) mol L(-1) for Pb(II), 3.81 × 10(-7) mol L(-1) for Cu(II), 6.79 × 10(-7) mol L(-1) for Hg(II). One of the benefits of this study was the determination of the amount of Hg(II) in the mixture of other elements.

  8. [History of the Journées Dermatologiques de Paris].

    Science.gov (United States)

    Tilles, G

    2013-12-01

    Founded in 1801 at the Hôpital Saint-Louis, Paris, under Jean-Louis Alibert, the French School of Dermatology was initially structured around the French Society of Dermatology (1889) and the organization of two world congresses (Paris 1889, 1900). After World War I, the creation of dermatological societies in the provinces infused French dermatology with new energy. In 1922, the first congress of the French-speaking dermatologists further contributed to the public profile of dermatologists in France. The "Journées de Mars" were initiated in 1961 at the Hôpital Saint-Louis, and in 1975 they went on to become the "Journées dermatologiques de Paris". Pr. Jean Civatte played a key role in their creation and in their organization for 30 years. After 1979, since actual patients could no longer be presented, the organizers of the congress had to change the content of the meeting from clinical presentations to post-graduate teaching and clinical research. From its origins in the form of meetings of French dermatologists in an intimate setting at the Hôpital Saint-Louis, the "Journées dermatologiques de Paris" grew within the ensuing decades into a major scientific event of the French-speaking dermatological community, bringing together more than 4000 participants in December each year. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  9. Analizadores Multilingües en FreeLing

    Directory of Open Access Journals (Sweden)

    Lluís Padró

    2012-01-01

    Full Text Available FreeLing es una librería de código abierto para el procesamiento multilíngüe automático, que proporciona una amplia gama de servicios de análisis lingüístico para diversos idiomas. FreeLing ofrece a los desarrolladores de aplicaciones de Procesamiento del Lenguaje Natural funciones de análisis y anotación lingüística de textos, con la consiguiente reducción del coste de construcción de dichas aplicaciones. FreeLing es personalizable y ampliable, y está fuertemente orientado a aplicaciones del mundo real en términos de velocidad y robustez. Los desarrolladores pueden utilizar los recursos lingüísticos por defecto (diccionarios, lexicones, gramáticas, etc, ampliarlos, adaptarlos a dominios particulares, o –dado que la librería es de código abierto– desarrollar otros nuevos para idiomas específicos o necesidades especiales de las aplicaciones. Este artículo presenta los principales cambios y mejoras incluidos en la versión 3.0 de FreeLing, y resume algunos proyectos industriales relevantes en los que se ha utilizado.

  10. Solar Energy Grid Integration Systems -- Energy Storage (SEGIS-ES).

    Energy Technology Data Exchange (ETDEWEB)

    Hanley, Charles J.; Ton, Dan T. (U.S. Department of Energy, Washington, D.C.); Boyes, John D.; Peek, Georgianne Huff

    2008-07-01

    This paper describes the concept for augmenting the SEGIS Program (an industry-led effort to greatly enhance the utility of distributed PV systems) with energy storage in residential and small commercial applications (SEGIS-ES). The goal of SEGIS-ES is to develop electrical energy storage components and systems specifically designed and optimized for grid-tied PV applications. This report describes the scope of the proposed SEGIS-ES Program and why it will be necessary to integrate energy storage with PV systems as PV-generated energy becomes more prevalent on the nation's utility grid. It also discusses the applications for which energy storage is most suited and for which it will provide the greatest economic and operational benefits to customers and utilities. Included is a detailed summary of the various storage technologies available, comparisons of their relative costs and development status, and a summary of key R&D needs for PV-storage systems. The report concludes with highlights of areas where further PV-specific R&D is needed and offers recommendations about how to proceed with their development.

  11. Cd(II), Cu(II)

    African Journals Online (AJOL)

    user

    Depending on the way goethite was pretreated with oxalic acid, affinity for Cd(II) varied ...... Effects and mechanisms of oxalate on Cd(II) adsorption on goethite at different ... precipitation, surfactant mediation, hydrothermal and micro-emulsion.

  12. Copper (II) addition to accelerate lactic acid production from co-fermentation of food waste and waste activated sludge: Understanding of the corresponding metabolisms, microbial community and predictive functional profiling.

    Science.gov (United States)

    Ye, Tingting; Li, Xiang; Zhang, Ting; Su, Yinglong; Zhang, Wenjuan; Li, Jun; Gan, Yanfei; Zhang, Ai; Liu, Yanan; Xue, Gang

    2018-03-20

    Bio-refinery of food waste and waste activated sludge to high value-added chemicals, such as lactic acid, has attracted particular interest in recent years. In this paper, the effect of copper (II) dosing to the organic waste fermentation system on lactic acid production was evaluated, which proved to be a promising method to stimulate high yield of lactic acid (77.0% higher than blank) at dosage of 15 μM-Cu 2+ /g VSS. As mechanism study suggested, copper addition enhanced the activity of α-glycosidase and glycolysis, which increased the substrate for subsequent acidification; whereas, the high dosage (70 μM-Cu 2+ /g VSS) inhibited the conversion of lactic acid to VFA, thus stabilized lactic acid concentration. Microbial community study revealed that small amount of copper (II) at 15 μM/g VSS resulted in the proliferation of Lactobacillus to 82.6%, which mainly produced lactic acid. Finally, the variation of functional capabilities implied that the proposed homeostatic system II was activated at relatively low concentration of copper. Meanwhile, membrane transport function and carbohydrate metabolism were also strengthened. This study provides insights into the effect of copper (II) on the enhancement of lactic acid production from co-fermentation of food waste and waste activated sludge. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. WALS Prediction

    NARCIS (Netherlands)

    Magnus, J.R.; Wang, W.; Zhang, Xinyu

    2012-01-01

    Abstract: Prediction under model uncertainty is an important and difficult issue. Traditional prediction methods (such as pretesting) are based on model selection followed by prediction in the selected model, but the reported prediction and the reported prediction variance ignore the uncertainty

  14. Development of Decision Support Formulas for the Prediction of Bladder Outlet Obstruction and Prostatic Surgery in Patients With Lower Urinary Tract Symptom/Benign Prostatic Hyperplasia: Part II, External Validation and Usability Testing of a Smartphone App

    Directory of Open Access Journals (Sweden)

    Min Soo Choo

    2017-04-01

    Full Text Available Purpose We aimed to externally validate the prediction model we developed for having bladder outlet obstruction (BOO and requiring prostatic surgery using 2 independent data sets from tertiary referral centers, and also aimed to validate a mobile app for using this model through usability testing. Methods Formulas and nomograms predicting whether a subject has BOO and needs prostatic surgery were validated with an external validation cohort from Seoul National University Bundang Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center between January 2004 and April 2015. A smartphone-based app was developed, and 8 young urologists were enrolled for usability testing to identify any human factor issues of the app. Results A total of 642 patients were included in the external validation cohort. No significant differences were found in the baseline characteristics of major parameters between the original (n=1,179 and the external validation cohort, except for the maximal flow rate. Predictions of requiring prostatic surgery in the validation cohort showed a sensitivity of 80.6%, a specificity of 73.2%, a positive predictive value of 49.7%, and a negative predictive value of 92.0%, and area under receiver operating curve of 0.84. The calibration plot indicated that the predictions have good correspondence. The decision curve showed also a high net benefit. Similar evaluation results using the external validation cohort were seen in the predictions of having BOO. Overall results of the usability test demonstrated that the app was user-friendly with no major human factor issues. Conclusions External validation of these newly developed a prediction model demonstrated a moderate level of discrimination, adequate calibration, and high net benefit gains for predicting both having BOO and requiring prostatic surgery. Also a smartphone app implementing the prediction model was user-friendly with no major human factor issue.

  15. Karakteristik Es Krim Bengkuang Dengan Menggunakan Beberapa Jenis Susu

    Directory of Open Access Journals (Sweden)

    Failisnur Failisnur

    2013-06-01

    Full Text Available Ice cream is a frozen dairy solid product with the addition of other materials that are made through the process of freezing and agitation. The principle of its making to form a cavity of air in the mixture of ice cream ingredients to produce a volume that made the development of the ice cream into a lighter, less dense and has a soft texture. The purposed of the research to see influence the use of a variety of milk to the physical properties, chemical properties and organoleptic to the bengkoang ice cream produced. Research carried out by treatment type of milk used that were fullcream milk, sweetened condensed milk, soy milk powder, green bean powder, and soy milk liquid. The ice cream produced was tested the physics of overrun and melting speed, chemical analysis of protein content, fat and organoleptic of taste and texture. Research results showed that the best treatment was the use of soy milk powder where the value of overrun 37.2%, melting speed 10.1 minutes, protein content 6.9%, fat 13.08%, and organoleptic of  taste and texture was preferred.ABSTRAKEs krim merupakan produk olahan susu beku berbentuk padat dengan penambahan  bahan lain yang dibuat melalui proses pembekuan dan agitasi.  Prinsip pembuatan es krim adalah membentuk suatu rongga udara pada campuran bahan-bahan es krim sehingga dihasilkan pengembangan volume yang membuat es krim menjadi lebih ringan, tidak terlalu padat dan mempunyai tekstur yang lembut. Tujuan penelitian adalah untuk melihat pengaruh dari penggunaan beberapa jenis susu terhadap sifat fisik, kimia dan organoleptik es krim bengkuang yang dihasilkan.  Penelitian dilakukan dengan perlakuan  penggunaan susu fullcream, susu kental manis, susu kedelai bubuk, kacang hijau bubuk, dan susu kedelai cair.  Es krim yang dihasilkan dilakukan uji fisika overrun dan kecepatan meleleh, analisis kimia kadar protein, lemak dan uji organoleptik rasa dan tekstur. Hasil penelitan menunjukkan bahwa penggunaan susu kedelai

  16. Cu(II) AND Zn(II)

    African Journals Online (AJOL)

    Preferred Customer

    SYNTHESIS OF 2,2-DIMETHYL-4-PHENYL-[1,3]-DIOXOLANE USING ZEOLITE. ENCAPSULATED Co(II), Cu(II) AND Zn(II) COMPLEXES. B.P. Nethravathi1, K. Rama Krishna Reddy2 and K.N. Mahendra1*. 1Department of Chemistry, Bangalore University, Bangalore-560001, India. 2Department of Chemistry, Government ...

  17. Elizabeth II uus kunstigalerii

    Index Scriptorium Estoniae

    1999-01-01

    Tähistamaks oma troonile asumise 50. aastapäeva, avab Elizabeth II 6. II 2002 Buckinghami palees uue kunstigalerii, mis ehitatakse palee tiibhoonena. Arhitekt John Simpson. Elizabeth II kunstikogust

  18. Neoplasmas da tireoide em cães: 26 casos

    Directory of Open Access Journals (Sweden)

    Camila Tochetto

    Full Text Available RESUMO: Foram revisados os protocolos de biópsias e necropsias do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV/UFSM entre 2004 e 2014, e todos os casos de tumores que acometeram a glândula tireoide foram selecionados. A partir disso, foram anotados sexo, idade e raça dos cães afetados. Também foi avaliado o significado clínico dos tumores, presença de aumento de volume cervical, lobos afetados, tamanho dos tumores, presença e localização de metástases e padrão histológico dos neoplasmas. Nos 11 anos que compreenderam este estudo, foram diagnosticados 26 tumores de glândula tireoide (quatro eram provenientes de exames de biópsias e 22 de necropsias, 53,9% dos cães eram fêmeas e 46,1% eram machos; 65,4% eram cães com raça definida. Desses, Boxers foram os mais afetados (15,4% dos casos. Dos 23 protocolos em que a idade foi informada, 60,9% dos cães eram idosos e 39,1% eram adultos. A avaliação dos protocolos permitiu constatar que 38,5% dos animais haviam apresentado aumento de volume cervical no momento do exame clínico. Dos cães necropsiados 13,6% morreram ou foram submetidos à eutanásia em decorrência de complicações causadas por metástases dos tumores de tireoide. Dessa forma, em 86,4% dos cães, os neoplasmas foram considerados achados incidentais de necropsia. Nos quatro casos provenientes de material de biópsia, o desfecho não foi conhecido. Em nenhum cão os tumores causaram síndrome clínica devido à hipo ou hiperfunção da tireoide. Em 24 protocolos havia informação sobre os lobos afetados e 75% dos cães tiveram acometimento unilateral da glândula. Os diagnósticos histológicos dos tumores permitiram constatar que 16 (61,5% neoplasmas eram carcinomas de células foliculares (nesses casos, o padrão folicular-compacto foi o mais frequente [43,75%], seis (23,1% eram adenomas de células foliculares, dois (7,7% eram carcinossarcomas e dois (7,7% eram tumores de c

  19. Lo que es dentro es fuera. Arteterapia con una niña en Régimen de Acogimiento Residencial

    OpenAIRE

    Rosario Macías, Marta del

    2014-01-01

    La investigación que se presenta a continuación “Lo que es dentro es fuera”, muestra un estudio con caso de corte cualitativo, abordado tras una intervención arteterapéutica adaptada a una niña de edad preescolar que se encuentra en Régimen de Acogimiento Residencial. Este texto pretende aportar una visión holística de la experiencia que nace a raíz de una conducta disruptiva, y de cómo a través de las sesiones de arteterapia y la influencia de su espacio simbólico enmarcado en unos límite...

  20. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM4_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  1. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM1_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  2. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM4_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  3. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_PFM+FM2_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  4. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM3_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  5. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_PFM+FM1_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  6. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM2_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2003-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  7. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM4_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  8. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM1_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  9. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM3_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  10. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM2_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  11. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_FM1+FM2_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2002-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  12. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Terra-FM2_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-10-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  13. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM4_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  14. CERES ERBE-like Monthly Geographical Averages (ES-4) in HDF (CER_ES4_Aqua-FM3_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ERBE-like Monthly Geographical Averages (ES-4) product contains a month of space and time averaged Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The ES-4 is also produced for combinations of scanner instruments. For each observed 2.5-degree spatial region, the daily average, the hourly average over the month, and the overall monthly average of shortwave and longwave fluxes at the Top-of-the-Atmosphere (TOA) from the CERES ES-9 product are spatially nested up from 2.5-degree regions to 5- and 10-degree regions, to 2.5-, 5-, and 10-degree zonal averages, and to global monthly averages. For each nested area, the albedo and net flux are given. For each region, the daily average flux is estimated from an algorithm that uses the available hourly data, scene identification data, and diurnal models. This algorithm is 'like' the algorithm used for the Earth Radiation Budget Experiment (ERBE). The following CERES ES4 data sets are currently available: CER_ES4_FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition1 CER_ES4_PFM+FM1+FM2_Edition2 CER_ES4_PFM+FM1_Edition1 CER_ES4_PFM+FM2_Edition1 CER_ES4_TRMM-PFM_Edition1 CER_ES4_TRMM-PFM_Edition2 CER_ES4_Terra-FM1_Edition1 CER_ES4_Terra-FM2_Edition1 CER_ES4_FM1+FM2_Edition2 CER_ES4_Terra-FM1_Edition2 CER_ES4_Terra-FM2_Edition2 CER_ES4_Aqua-FM3_Edition1 CER_ES4_Aqua-FM4_Edition1 CER_ES4_FM1+FM2+FM3+FM4_Edition1 CER_ES4_Aqua-FM3_Edition2 CER_ES4_Aqua-FM4_Edition2 CER_ES4_FM1+FM3_Edition2 CER_ES4_FM1+FM4_Edition2 CER_ES4_PFM+FM1_Edition2 CER_ES4_PFM+FM2_Edition2 CER_ES4_Aqua-FM3_Edition1-CV CER_ES4_Aqua-FM4_Edition1-CV CER_ES4_Terra-FM1_Edition1-CV CER_ES4_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=2.5 degree; Longitude_Resolution=2.5 degree; Horizontal

  15. ¿Qué es la CIE y por qué es importante en la psicología?

    Directory of Open Access Journals (Sweden)

    Geoffrey M. Reed

    2012-01-01

    Full Text Available La Clasificación Internacional de las Enfermedades (CIE de la Organización Mundial de Salud (OMS es muy poco conocida en el ámbito de la psicología en España, y existe la falsa percepción de que su importancia es escasa en el campo de la salud mental. El propósito de este artículo es familiarizar a los psicólogos y otros profesionales en salud mental con el sistema de clasificación CIE, algo especialmente relevante al encontrarse actualmente en proceso de revisión. La OMS está haciendo un gran esfuerzo para crear una clasificación de trastornos mentales global, multicultural y multidisciplinar, centrándose en mejorar su utilidad clínica. Además, en la actual revisión de la CIE, la OMS ha adoptado el español como segunda lengua de trabajo, lo que da una gran oportunidad a los profesionales de la salud mental de España y otros países hispanohablantes de implicarse activamente en el desarrollo de la próxima versión de la clasificación. Es importante que los psicólogos de países hispanohablantes conozcan la CIE y entiendan los grandes beneficios que pueden aportarles su conocimiento y utilización para integrarse plenamente como profesión sanitaria oficial, así como para equipararse en la práctica de la psicología al resto de Europa y de todo el mundo en términos de diagnóstico y clasificación de los trastornos mentales.

  16. Approches de l'utilisation des eaux usées urbaines dans l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 févr. 2011 ... Ils proposent une classification des différents types d'eaux usées (directes, indirectes, traitées, non traitées, dirigées et non dirigées), soulignent combien il est nécessaire d'utiliser une approche fondée sur les moyens de subsistance et ciblée sur les agriculteurs, insistent sur des directives pragmatiques ...

  17. Der II. Hauptsatz der Wärmelehre

    Science.gov (United States)

    Heintze, Joachim

    Wir haben in (4.44) den II. Hauptsatz als empirische Tatsache folgendermaßen formuliert: (i) Wärmeenergie geht von selbst nur von einem wärmeren Körper auf einen kälteren über, niemals in der umgekehrten Richtung. Nun werden wir beweisen, dass sich aus diesem Prinzip folgende äquivalente Formulierungen für den II. Hauptsatz ableiten lassen: (ii) Es ist unmöglich, ein Perpetuum mobile zweiter Art zu bauen, d. h. eine Maschine, die fortlaufend Wärmeenergie vollständig in mechanische Arbeit umsetzen kann. Eine Wärmekraftmaschine, die einen Kreisprozess mit der höchsten Temperatur Tw und der niedrigsten Temperatur Tk durchläuft, hat höchstens den Carnotschen Wirkungsgrad c = (Tw - Tk)/Tw. Wenn in der Maschine nur reversible Prozesse ablaufen, die gesamte Wärmezufuhr bei der Temperatur Tw erfolgt und ausschließlich bei der Temperatur Tw gekühlt wird, ist ihr Wirkungsgrad = C. Es gibt keine Wärmekraftmaschine, die eine bessere Ausnutzung der Wärmeenergie ermöglicht. (iv) In jedem thermodynamischen System existiert die Zustandsgröße Entropie, definiert durch ihr Differential dS = (dQrev)/T . Entropie kann erzeugt, aber nicht vernichtet werden. Bei Zustandsänderungen, die in einem abgeschlossenen System ablaufen, nimmt die Entropie entweder zu (irreversible Prozesse), oder sie bleibt konstant (reversible Prozesse). Im Anschluss an (iii) werden wir zur Definition der thermodynamischen Temperatur und bei der Diskussion von (iv) zu einem tieferen Verständnis der Entropie gelangen. Es zeigt sich, dass die Entropie das eigentliche Bindeglied zwischen Mechanik und Wärmelehre darstellt. Am Ende des Kapitels werden wir einige Anwendungen des II. Hauptsatzes betrachten.

  18. ATMOSPHERE AND SPECTRAL MODELS OF THE KEPLER-FIELD PLANETS HAT-P-7b AND TrES-2

    International Nuclear Information System (INIS)

    Spiegel, David S.; Burrows, Adam

    2010-01-01

    We develop atmosphere models of two of the three Kepler-field planets that were known prior to the start of the Kepler mission (HAT-P-7b and TrES-2). We find that published Kepler and Spitzer data for HAT-P-7b appear to require an extremely hot upper atmosphere on the dayside, with a strong thermal inversion and little day-night redistribution. The Spitzer data for TrES-2 suggest a mild thermal inversion with moderate day-night redistribution. We examine the effect of nonequilibrium chemistry on TrES-2 model atmospheres and find that methane levels must be adjusted by extreme amounts in order to cause even mild changes in atmospheric structure and emergent spectra. Our best-fit models to the Spitzer data for TrES-2 lead us to predict a low secondary eclipse planet-star flux ratio (∼ -5 ) in the Kepler bandpass, which is consistent with what very recent observations have found. Finally, we consider how the Kepler-band optical flux from a hot exoplanet depends on the strength of a possible extra optical absorber in the upper atmosphere. We find that the optical flux is not monotonic in optical opacity, and the non-monotonicity is greater for brighter, hotter stars.

  19. TRANSWRAP II: problem definition manual

    International Nuclear Information System (INIS)

    Knittle, D.E.

    1981-02-01

    The TRANSWRAP II computer code, written in Fortran IV and described in this Problem Definition Manual, was developed to analytically predict the magnitude of pressure pulses of large scale sodium-wate reactions in LMFBR secondary systems. It is currently being used for the Clinch River Breeder Reactor Program. The code provides the options, flexibility and features necessary to consider any system configuration. The code methodology has been validated with the aid of extensive sodium-water reaction test programs

  20. ERP II: a conceptual framework for next-generation enterprise systems?

    DEFF Research Database (Denmark)

    Møller, Charles

    2005-01-01

    proposes a conceptual framework for extended enterprise resource planning (ERP II). The aim of this model is to compile present ES concepts into a comprehensive outline of ERP II, thus composing a generic map and taxonomy for corporate-wide enterprise systems. Research limitations/implications - The paper...

  1. The four Es of problem gambling: a psychological measure of risk.

    Science.gov (United States)

    Rockloff, Matthew J; Dyer, Victoria

    2006-01-01

    A focus group of Reno area Gamblers Anonymous members identified four psychological traits contributing to risk for problem gambling, including: Escape, Esteem, Excess and Excitement. A panel of four experts authored 240 Likert-type items to measure these traits. By design, none of the items explicitly referred to gambling activities. Study 1 narrowed the field of useful items by employing a quasi-experimental design which compared the answers of Reno area Gamblers Anonymous members (N = 39) to a control sample (N = 34). Study 2 submitted successful items, plus new items authored with the knowledge gained from Study 1, to validation in a random sample telephone survey across Queensland, Australia (N=2577). The final 40 item Four Es scale (4Es) was reliable (alpha=.90); predicted gambling problems as measured by the Canadian Problem Gambling Index of Severity (PGSI, Ferris & Wynne (2001). The Canadian Problem Gambling Index: Final Report: Canadian Centre on Substance Abuse); and distinguished problem gamblers from persons with alcohol abuse problems. The new scale can provide a basis for further study in harm minimization, treatment, and theory development.

  2. Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II ...

    Indian Academy of Sciences (India)

    Unknown

    Synthesis and characterisation of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) Schiff base complexes derived from o-phenylenediamine and acetoacetanilide. N RAMAN*, Y PITCHAIKANI RAJA and A KULANDAISAMY. Department of Chemistry, VHNSN College, Virudhunagar 626 001, India e-mail: ra_man@123india.com.

  3. Macrocyclic receptor showing extremely high Sr(II)/Ca(II) and Pb(II)/Ca(II) selectivities with potential application in chelation treatment of metal intoxication.

    Science.gov (United States)

    Ferreirós-Martínez, Raquel; Esteban-Gómez, David; Tóth, Éva; de Blas, Andrés; Platas-Iglesias, Carlos; Rodríguez-Blas, Teresa

    2011-04-18

    Herein we report a detailed investigation of the complexation properties of the macrocyclic decadentate receptor N,N'-Bis[(6-carboxy-2-pyridil)methyl]-4,13-diaza-18-crown-6 (H(2)bp18c6) toward different divalent metal ions [Zn(II), Cd(II), Pb(II), Sr(II), and Ca(II)] in aqueous solution. We have found that this ligand is especially suited for the complexation of large metal ions such as Sr(II) and Pb(II), which results in very high Pb(II)/Ca(II) and Pb(II)/Zn(II) selectivities (in fact, higher than those found for ligands widely used for the treatment of lead poisoning such as ethylenediaminetetraacetic acid (edta)), as well as in the highest Sr(II)/Ca(II) selectivity reported so far. These results have been rationalized on the basis of the structure of the complexes. X-ray crystal diffraction, (1)H and (13)C NMR spectroscopy, as well as theoretical calculations at the density functional theory (B3LYP) level have been performed. Our results indicate that for large metal ions such as Pb(II) and Sr(II) the most stable conformation is Δ(δλδ)(δλδ), while for Ca(II) our calculations predict the Δ(λδλ)(λδλ) form being the most stable one. The selectivity that bp18c6(2-) shows for Sr(II) over Ca(II) can be attributed to a better fit between the large Sr(II) ions and the relatively large crown fragment of the ligand. The X-ray crystal structure of the Pb(II) complex shows that the Δ(δλδ)(δλδ) conformation observed in solution is also maintained in the solid state. The Pb(II) ion is endocyclically coordinated, being directly bound to the 10 donor atoms of the ligand. The bond distances to the donor atoms of the pendant arms (2.55-2.60 Å) are substantially shorter than those between the metal ion and the donor atoms of the crown moiety (2.92-3.04 Å). This is a typical situation observed for the so-called hemidirected compounds, in which the Pb(II) lone pair is stereochemically active. The X-ray structures of the Zn(II) and Cd(II) complexes show that

  4. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Aqua-FM4_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  5. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Terra-FM1_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-01-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  6. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Terra-FM1_Edition1-CV)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-09-30] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  7. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Terra-FM2_Edition1)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-11-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  8. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Aqua-FM3_Edition2)

    Science.gov (United States)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  9. ¿Es posible enseñar emprendimiento?

    OpenAIRE

    Gutiérrez Molina, Catalina; Jaramillo Ángel, Alejandro

    2015-01-01

    El emprendimiento se ha convertido en una de las principales oportunidades de desarrollo económico para los países subdesarrollados debido a su capacidad de innovación y generación de empleo; por eso, en años recientes gobiernos, grandes corporaciones y universidades han revisado desde diferentes visiones y programas la manera de fomentar y apoyar a los emprendedores como parte del tejido empresarial y social -- En Colombia, el Congreso expidió la ley 1014 de 2006 con el fin de fomentar el es...

  10. ¿Es el lugar de apego un lugar restaurador?

    OpenAIRE

    Hidalgo-Villodres, María del Carmen; Hernández, Bernardo; Ruiz, Cristina; Negrín, Fátima

    2014-01-01

    La investigación sobre apego al lugar ha puesto de manifiesto la importancia que tienen los ambientes residenciales en el desarrollo de fuertes vínculos afectivos hacia algunos ambientes con los que interactuamos en nuestra vida diaria. Podemos definir el apego al lugar como el vínculo afectivo positivo entre un individuo y un determinado lugar, cuya principal característica es la tendencia a mantener la proximidad con ese lugar (Hidalgo y Hernández, 2001). Hasta el momento, el apego al lugar...

  11. ¿Qué es una onda ecuatorial de Kelvin?

    OpenAIRE

    Ripa, P.

    1980-01-01

    La importancia del estudio de las ondas de Kelvin (ecuatoriales o costeras) radica, en parte, en el hecho de que éstas proveen un mecanismo eficaz para el transporte de energía (en la forma de perturbaciones de densidad y corriente) en una dirección particular. Estas señales se trasladan sin dispersión, es decir, sin cambiar de forma. Por otra parte, una onda de Kelvin provee un ejemplo muy sencillo de dos fenómenos fundamentales de la Oceanografía Física de frecuencias: el balance geostrófic...

  12. Mirar l'aula com es mira una imatge

    Directory of Open Access Journals (Sweden)

    Francisca Beneyto Ruiz

    2014-12-01

    Full Text Available En aquest article es proposa una metodologia d'aproximació a l'aula entenent-la a través del concepte d'imatge tal com ho contemplen els Estudis Visuals. Al llarg de tot el desenvolupament vaig apropant el concepte d'imatge i el concepte d'aula creant vincles entre un i altre. Si la imatge no és una estructura sinó un estructurant, l'aula és, igualment, un espai de construcció contínua on cada element i cada relació compten.

  13. Maladies reliées aux loisirs aquatiques

    Science.gov (United States)

    Sanborn, Margaret; Takaro, Tim

    2013-01-01

    Résumé Objectif Passer en revue les facteurs de risque, la prise en charge et la prévention des maladies reliées aux loisirs aquatiques en pratique familiale. Sources des données Des articles originaux et de synthèse entre janvier 1998 et février 2012 ont été identifiés à l’aide de PubMed et des expressions de recherche en anglais water-related illness, recreational water illness et swimmer illness. Message principal Il y a un risque de 3 % à 8 % de maladies gastrointestinales (MGI) après la baignade. Les groupes à risque élevé de MGI sont les enfants de moins de 5 ans, surtout s’ils n’ont pas été vaccinés contre le rotavirus, les personnes âgées et les patients immunodéficients. Les enfants sont à plus grand risque parce qu’ils avalent plus d’eau quand ils nagent, restent dans l’eau plus longtemps et jouent dans l’eau peu profonde et le sable qui sont plus contaminés. Les adeptes des sports dans lesquels le contact avec l’eau est abondant comme le triathlon et le surf cerf-volant sont aussi à risque élevé et même ceux qui s’adonnent à des activités impliquant un contact partiel avec l’eau comme la navigation de plaisance et la pêche ont un risque de 40 % à 50 % fois plus grand de MGI par rapport à ceux qui ne pratiquent pas de sports aquatiques. Il y a lieu de faire une culture des selles quand on soupçonne une maladie reliée aux loisirs aquatiques et l’échelle clinique de la déshydratation est utile pour l’évaluation des besoins de traitement chez les enfants affectés. Conclusion Les maladies reliées aux loisirs aquatiques est la principale cause de MGI durant la saison des baignades. La reconnaissance que la baignade est une source importante de maladies peut aider à prévenir les cas récurrents et secondaires. On recommande fortement le vaccin contre le rotavirus chez les enfants qui se baignent souvent.

  14. ¿la responsabilidad es solo de los medios?

    Directory of Open Access Journals (Sweden)

    Blasco Fernando Checa Montúfar

    2015-01-01

    Full Text Available La información ambiental y, la generación de una opinión pública favorable a la causa, es ¿responsabilidad exclusiva de los medios y periodistas?, ¿Son éstos los únicos que deben obtener información, procesarla y presentarle adecuadamente al público?, ¿De ellos depende la optimización de flujos informativos sobre el medio ambiente, en todas las instancias del proceso que ese flujo implica? Estas interrogantes son analizadas en base a un breve diagnóstico realizado por los organismos ambientalistas del Ecuador.

  15. Feeding Dar es Salaam: a symbiotic food system perspective

    OpenAIRE

    Wegerif, Marc C.A.

    2017-01-01

    This thesis is a sociological analysis of the agri-food system that feeds most of the over four and a half million residents of the fast-growing city of Dar es Salaam in Tanzania. It is based on qualitative research that has generated a picture of the food system that supplies the important foods for the majority of residents of the city. The research took an actor orientated approach and started from urban eaters and then followed the food back through retailers, processors and transporters ...

  16. Untersuchungen zum Einfluss einer Air-Liquid-Interphase auf die Differenzierung von Alveolarepithelzellen Typ II

    OpenAIRE

    Sinis, Nektarios

    2003-01-01

    Die Dedifferenzierung der Alveolarepithelzellen Typ II stellt in vitro ein großes Problem dar. Zellen, die länger als 48 Stunden in vitro kultiviert werden tendieren zu einer Dedifferenzierung. Die vorliegende Arbeit stellt ein Air-Liquid-Interphasesystem zur Kultivierung von TypII-Zellen vor. Hierdurch ist es uns gelungen TypII-Zellen über einen Zeitraum von bis zu 14 Tagen in vitro auf einem hohen Grad der Differenzierung zu konservieren. Zellen die nicht so kultiviert wurden zeigten fr...

  17. Photohadronic scenario in interpreting the February-March 2014 flare of 1ES 1011+496

    Energy Technology Data Exchange (ETDEWEB)

    Sahu, Sarira [Universidad Nacional Autonoma de Mexico, Instituto de Ciencias Nucleares, Circuito Exterior, Mexico (Mexico); RIKEN, Astrophysical Big Bang Laboratory, Wako, Saitama (Japan); Rosales de Leon, Alberto [Universidad Nacional Autonoma de Mexico, Instituto de Ciencias Nucleares, Circuito Exterior, Mexico (Mexico); Salvador Miranda, Luis [University of Johannesburg, Department of Physics, Auckland Park (South Africa)

    2017-11-15

    The extraordinary multi-TeV flare from 1ES 1011+496 during February-March 2014 was observed by the MAGIC telescopes for 17 nights and the average spectrum of the whole period has a non-trivial shape. We have used the photohadronic model and a template extragalactic background light model to explain the average spectrum which fits the flare data well. The spectral index α is the only free parameter in our model. We have also shown that the non-trivial nature of the spectrum is due to the change in the behavior of the optical depth above ∝ 600 GeV γ-ray energy accompanied with the high SSC flux. This corresponds to an almost flat intrinsic flux for the multi-TeV γ-rays. Our model prediction can constrain the SSC flux of the leptonic models in the quiescent state. (orig.)

  18. Photohadronic scenario in interpreting the February-March 2014 flare of 1ES 1011+496

    Science.gov (United States)

    Sahu, Sarira; de León, Alberto Rosales; Miranda, Luis Salvador

    2017-11-01

    The extraordinary multi-TeV flare from 1ES 1011+496 during February-March 2014 was observed by the MAGIC telescopes for 17 nights and the average spectrum of the whole period has a non-trivial shape. We have used the photohadronic model and a template extragalactic background light model to explain the average spectrum which fits the flare data well. The spectral index α is the only free parameter in our model. We have also shown that the non-trivial nature of the spectrum is due to the change in the behavior of the optical depth above ˜ 600 GeV γ -ray energy accompanied with the high SSC flux. This corresponds to an almost flat intrinsic flux for the multi-TeV γ -rays. Our model prediction can constrain the SSC flux of the leptonic models in the quiescent state.

  19. Determinants of High Blood Pressure and Barriers to Diagnosis and Treatment in Dar es Salaam, Tanzania

    Science.gov (United States)

    ZACK, Rachel M.; IREMA, Kahema; KAZONDA, Patrick; LEYNA, Germana H.; LIU, Enju; SPIEGELMAN, Donna; FAWZI, Wafaie; NJELEKELA, Marina; KILLEWO, Japhet; DANAEI, Goodarz

    2017-01-01

    Objectives We assessed prevalence and determinants of high blood pressure, and barriers to diagnosis and treatment, in Dar es Salaam, Tanzania. Methods We surveyed and screened 2,174 community-dwelling adults aged ≥40 years in 2014 and conducted a follow-up after one year. Results Median blood pressure was 131/81 mmHg and hypertension prevalence was 37%. Mean adjusted difference in SBP was 4.0 mmHg for overweight, 6.3 mmHg for obese class I, and 10.5 mmHg for obese class II/III compared with normal weight participants. Those who were physically inactive had 4.8 mmHg higher SBP compared to those with more than 24 hours of moderate or vigorous activity per week. Drinkers of at least 10 grams of alcohol per day had 4.5 mmHg higher SBP than did non-drinkers. Among hypertensives, 48% were diagnosed, 22% were treated, and 10% were controlled. Hypertensives without health insurance were 12% less likely to be diagnosed than insured hypertensives. Of referred participants, 68% sought care, but only 27% were on treatment and 8% had controlled blood pressure at follow-up. Reasons for not seeking care included lack of symptoms, cost of visit, and lack of time. Reasons for not being on treatment included lack of symptoms, not being prescribed treatment, and having finished one course of treatment. Conclusions Major risk factors for hypertension in Dar es Salaam are overweight, obesity, inadequate physical activity, and limited access to quality medical care. Increased insurance coverage and community-based screening, along with quality medical care and patient education, may help control this burgeoning epidemic. PMID:27648720

  20. ¿Qué es el Open Journal System?

    Directory of Open Access Journals (Sweden)

    Natalia I. Osorio Curbelo

    2015-12-01

    Full Text Available ¿Qué es el Open Journal System (OJS? Es un  software de código abierto. ¿Qué significa  “Código Abierto“? El acceso abierto (en inglés, open access es el acceso inmediato, sin requerimientos de registro, suscripción o pago, es decir sin restricciones, a material digital educativo, académico, científico o de cualquier otro tipo, principalmente artículos de investigación científica de revistas especializadas con peer review (revisión por pares. Significa que cualquier usuario individual pueda leer, descargar, copiar, distribuir, imprimir, buscar o enlazar los textos completos de los artículos científicos, y usarlos con cualquier otro propósito legítimo, como hacer minería de datos de su contenido digital, sin otras barreras económicas, legales o técnicas que las que suponga Internet en sí misma. Es decir, es una manera gratuita y abierta de acceder a la literatura científica. Para qué sirve? Permite controlar todo el proceso de publicación:- El envío de los manuscritos, por parte de los autores. - Selección de los revisores, por parte de los editores. - La revisión, por parte de los revisores primero y luego por los autores mismos. - La corrección de estilos y de sintaxis. - La diagramación/maquetación. - La publicación misma del artículo. - Lectura (con herramientas de lectura. - Indexación en bases de datos y buscadores.Características de OJS- Se instala y se controla de manera local en un servidor Web propio. - Los editores pueden configurar los requisitos, secciones, el proceso de revisión, etc. - Todos los contenidos se envían y se gestionan online. - Permite el envío por e-mail de los artículos y la inserción de comentarios por parte de los lectores. - Cuenta con un módulo de suscripción, con la opción de pasar los artículos a libre acceso, pasado un tiempo. - Cuenta con herramientas de lectura, basadas en la configuración proporcionada por el editor. - Como parte del sistema, cuenta con la

  1. TER HANSENIASE: PERCEPÇÕES DE PESSOAS EM TRATAMENTO

    Directory of Open Access Journals (Sweden)

    JOYCE MAZZA NUNES

    2008-01-01

    Full Text Available La lepra es una enfermedad milenaria, caracterizada como un problema de salud pública. Desarrollamos este estudio con el objetivo de conocer la percepción sobre su enfermedad de las personas en tratamiento para lepra. Se trata de un estudio con planteo cualitativo, desarrollado a través de un grupo focal en el mes de agosto de 2005 con ocho personas en tratamiento para lepra multibacilar en la Unidad Básica de Salud en Sobral-CE. Las declaraciones señalaron que la lepra es vista como una enfermedad mala, que trae tristeza, miedo, vergüenza y discriminación. Ser portador de lepra ocasionó sufrimiento psíquico y sentimientos de impotencia, hombres y mujeres tuvieron sus roles sociales amenazados. Sugerimos que se idealicen alternativas que atiendan no sólo la eliminación de la lepra como un problema de salud pública, sino también, como un rescate de la ciudadanía y del respeto por esas personas.

  2. La educación inclusiva es nuestra tarea

    Directory of Open Access Journals (Sweden)

    Meybol Calderón

    2012-06-01

    Full Text Available La educación inclusiva es un tema que se ha venido trabajando desde hace relativamente pocos años en el Perú, pero en otros países se viene realizando desde hace muchos años. Por ello esta investigación busca dar a conocer todos aquellos elementos que son necesarios para lograr una inclusión adecuada de los niños, tomando como centro al niño, reconociéndolo como un ser humano integral que no solo aprende conceptos, sino también aprende a convivir e interactuar con su medio. Es aquí donde debemos tomar en cuenta el respeto a la diversidad que se debe dar en el aula, ya que al convivir se comparten experiencias con personas diferentes, como pueden ser los niños con necesidades especiales o simplemente con las de un niño regular. En esta investigación hemos querido resaltar la importancia de los roles de los agentes educativos para el buen desarrollo de la inclusión de los niños, siendo estos indispensables para lograrlo.

  3. AÇÕES EDUCATIVAS PARA TERCEIRA IDADE

    Directory of Open Access Journals (Sweden)

    Rejane Millions Viana Meneses

    2013-01-01

    Full Text Available En el proceso del envejecimiento, anciano se enfrentan a la aparición de enfermedades crónicas que muchas veces reflejan en dificultades para el mantenimiento de la salud. En este contexto, es importante el trabajo con la tercera edad para promover la mejora del consiguiente estilo de vida. Este trabajo es un relato de experiencia de la ejecución de un proyecto de investigación de la Universidad Federal de Rio Grande do Norte , que lleva acciones educativas a la Asociación Inaraí (Natal/RN, con objetivo de divulgar actividades, así estimulando la formación de los grupos a que tienen como objetivo la promoción a salud de ancianos . Para desarrollar las acciones, según la informaciones recogidas en el perfil epidemiológico llevado previamente en la Asociación, por medio de reuniones semanales con anciano s, se buscó estimular buenos hábitos de vida , para llevar a cabo posible la mejora de lo estilo de vida y por lo tanto, promover salud de ese grupo.

  4. Urethral Stricture as seen in Dar es Salaam, Tanzania.

    African Journals Online (AJOL)

    dell

    urethritis have increasingly been incriminated as a major etiological factor of inflammatory urethral stricture especially in the developed world. Organisms which fall in this group include. Ureaplasma (T-strain), Mycoplasma, Trichomonas vaginalis, Candida albicans, and Haemophilus vaginalis, Herpes simplex virus type II, ...

  5. Derivation of hybrid ES cell lines from two different strains of mice

    Directory of Open Access Journals (Sweden)

    Ho-Tak Lau

    2016-03-01

    Full Text Available Parental origin-dependent expression of the imprinted genes is essential for mammalian development. Zfp57 maintains genomic imprinting in mouse embryos and ES cells. To examine the allelic expression patterns of the imprinted genes in ES cells, we obtained multiple hybrid ES clones that were directly derived from the blastocysts generated from the cross between mice on two different genetic backgrounds. The blastocyst-derived ES clones displayed largely intact DNA methylation imprint at the tested imprinted regions. These hybrid ES clones will be useful for future studies to examine the allelic expression of the imprinted genes in ES cells and their differentiated progeny.

  6. Transport with Astra in TJ-II

    International Nuclear Information System (INIS)

    Lopez-Bruna, D.; Castejon, F.; Fontdecaba, J. M.

    2004-01-01

    This report describes the adaptation of the numerical transport shell ASTRA for performing plasma calculations in the TJ-II stellarator device. Firstly, an approximation to the TJ-II geometry is made and a simple transport model is shared with two other codes in order to compare these codes (PROCTR, PRETOR-Stellarator) with ASTRA as calculation tool for TJ-II plasmas are provided: interpretative and predictive transport. The first consists in estimating the transport coefficients from real experimental data, thes being taken from three TJ-II discharges. The predictive facet is illustrated using a model that is able to includes self-consistently the dynamics of transport barriers. The report includes this model, written in the ASTRA programming language, to illustrate the use of ASTRA. (Author) 26 refs

  7. Climate prediction and predictability

    Science.gov (United States)

    Allen, Myles

    2010-05-01

    Climate prediction is generally accepted to be one of the grand challenges of the Geophysical Sciences. What is less widely acknowledged is that fundamental issues have yet to be resolved concerning the nature of the challenge, even after decades of research in this area. How do we verify or falsify a probabilistic forecast of a singular event such as anthropogenic warming over the 21st century? How do we determine the information content of a climate forecast? What does it mean for a modelling system to be "good enough" to forecast a particular variable? How will we know when models and forecasting systems are "good enough" to provide detailed forecasts of weather at specific locations or, for example, the risks associated with global geo-engineering schemes. This talk will provide an overview of these questions in the light of recent developments in multi-decade climate forecasting, drawing on concepts from information theory, machine learning and statistics. I will draw extensively but not exclusively from the experience of the climateprediction.net project, running multiple versions of climate models on personal computers.

  8. Developing Space Weather products and services in Europe – Preface to the Special Issue on COST Action ES0803

    Directory of Open Access Journals (Sweden)

    Belehaki Anna

    2014-01-01

    Full Text Available COST Action ES0803 “Developing Space Weather products and services in Europe” primarily aimed at forming an interdisciplinary network among European scientists dealing with different issues relevant to Geospace as well as warning system developers and operators in order to assess existing Space Weather products and recommend new ones. The work that has been implemented from 2008 to 2012 resulted in advances in modeling and predicting Space Weather, in recommendations for the validation of Space Weather models, in proposals for new Space Weather products and services, and in dissemination, training, and outreach activities. This preface summarizes the most important achievements of this European activity that are detailed in this special issue by the key scientists who participated in COST Action ES0803.

  9. FGF7 and cell density are required for final differentiation of pancreatic amylase-positive cells from human ES cells.

    Science.gov (United States)

    Takizawa-Shirasawa, Sakiko; Yoshie, Susumu; Yue, Fengming; Mogi, Akimi; Yokoyama, Tadayuki; Tomotsune, Daihachiro; Sasaki, Katsunori

    2013-12-01

    The major molecular signals of pancreatic exocrine development are largely unknown. We examine the role of fibroblast growth factor 7 (FGF7) in the final induction of pancreatic amylase-containing exocrine cells from induced-pancreatic progenitor cells derived from human embryonic stem (hES) cells. Our protocol consisted in three steps: Step I, differentiation of definitive endoderm (DE) by activin A treatment of hES cell colonies; Step II, differentiation of pancreatic progenitor cells by re-plating of the cells of Step I onto 24-well plates at high density and stimulation with all-trans retinoic acid; Step III, differentiation of pancreatic exocrine cells with a combination of FGF7, glucagon-like peptide 1 and nicotinamide. The expression levels of pancreatic endodermal markers such as Foxa2, Sox17 and gut tube endoderm marker HNF1β were up-regulated in both Step I and II. Moreover, in Step III, the induced cells expressed pancreatic markers such as amylase, carboxypeptidase A and chymotrypsinogen B, which were similar to those in normal human pancreas. From day 8 in Step III, cells immunohistochemically positive for amylase and for carboxypeptidase A, a pancreatic exocrine cell product, were induced by FGF7. Pancreatic progenitor Pdx1-positive cells were localized in proximity to the amylase-positive cells. In the absence of FGF7, few amylase-positive cells were identified. Thus, our three-step culture protocol for human ES cells effectively induces the differentiation of amylase- and carboxypeptidase-A-containing pancreatic exocrine cells.

  10. Eletrocardiografia computadorizada em cães: estudo comparativo

    Directory of Open Access Journals (Sweden)

    Lídia S. Oliveira

    2013-07-01

    Full Text Available O método de eletrocardiografia computadorizada (ECG-C vem sendo crescentemente difundido na medicina veterinária, havendo atualmente diversas marcas e modelos de eletrocardiógrafos disponíveis no mercado. Diante da possibilidade de diferenças na sensibilidade e na reprodutibilidade das medidas obtidas nos traçados, o presente estudo teve como objetivo comparar os parâmetros eletrocardiográficos de cães, obtidos por dois sistemas. Foram avaliados dois diferentes softwares computadorizados, o Wincardio Micromed® (WIN e o modelo TEB ECGPC® (TEB. Quarenta e dois cães hígidos, de diferentes raças (Cocker Spaniel, Daschund, Labrador, Pinscher, Pit Bull Terrier Poodle, Schnauzer, Shit Tzu, Yorkshire e sem raça definida, machos e fêmeas e com idade entre 4 meses e 16 anos foram agrupados segundo o peso e examinados pelos dois sistemas. As medidas eletrocardiográficas dos diferentes traçados foram analisadas na derivação DII. Os resultados indicaram que o sistema TEB apresentou maior sensibilidade na obtenção das medidas de duração da onda P e do complexo QRS, enquanto o sistema WIN foi mais sensível para determinar as medidas de amplitude dos mesmos parâmetros. Os animais de maior porte (26-37kg apresentaram maior variância nas medidas de duração e amplitude de onda P e duração do complexo QRS em comparação aos cães de médio (14-25kg e pequeno (1-13kg porte. O achado de diferenças entre os sistemas testados deve ser levado em consideração ao se empregar os diversos equipamentos para diagnóstico por meio de ECG-C na rotina clínica, de modo a evitarem-se divergências na interpretação dos exames entre diferentes prestadores de serviços veterinários.

  11. Postmodernidad y personalidad heroica, cuando el sufrimiento es placentero

    Directory of Open Access Journals (Sweden)

    Maximiliano Korstanje

    2015-01-01

    Full Text Available El presente ensayo examina no solo como se forma el miedo moderno y su relación con la tragedia, sino las diversas formas culturales de vivirla respecto al futuro. Se antepone la figura de la personalidad heroica como una construcción moderna centrada en la necesidad de sentir placer por la pérdida. Esta tendencia lleva a las personas a sentirse únicas respecto a otras. Si el héroe es aquel que no se doblega ante el destino, también es un ser que lleva tras sí una historia de dolor y sufrimiento. Ahora bien, tanto los países de raigambre cultural latino como los germánicos han elaborado diferentes formas de vivir lo trágico; lo cierto es que el futuro, como construcción social, juega un rol importante en dichos procesos. Mien- tras para los anglosajones el futuro se mantiene como una entidad inmutable que no puede ser modificada, para los latinos el futuro se construye solo desde el presente. Abstract This essay aims to review how to form not only the modern man’s fear and its relationship with tragedy but also the way to live it according to the future. Heroic per- sonality is chosen as a modern figure focused on the need of pleasure feeling by the loss. This trend makes people to consider themselves unique related to others. If the hero is that one who does not bow down to the fate, it is also a human being who has a pain and suffering story behind him. Now, in those countries of deep seated Latin cultural roots such as German countries have established differ- ent ways of living. One thing is true, the future as social construction plays an important role in those processes. While English speaking countries the future is kept as immutable entity which can not be modified . For Latin people future is built only based on the present. 

  12. [Fire behavior of Mongolian oak leaves fuel bed under no-wind and zero-slope conditions. II. Analysis of the factors affecting flame length and residence time and related prediction models].

    Science.gov (United States)

    Zhang, Ji-Li; Liu, Bo-Fei; Di, Xue-Ying; Chu, Teng-Fei; Jin, Sen

    2012-11-01

    Taking fuel moisture content, fuel loading, and fuel bed depth as controlling factors, the fuel beds of Mongolian oak leaves in Maoershan region of Northeast China in field were simulated, and a total of one hundred experimental burnings under no-wind and zero-slope conditions were conducted in laboratory, with the effects of the fuel moisture content, fuel loading, and fuel bed depth on the flame length and its residence time analyzed and the multivariate linear prediction models constructed. The results indicated that fuel moisture content had a significant negative liner correlation with flame length, but less correlation with flame residence time. Both the fuel loading and the fuel bed depth were significantly positively correlated with flame length and its residence time. The interactions of fuel bed depth with fuel moisture content and fuel loading had significant effects on the flame length, while the interactions of fuel moisture content with fuel loading and fuel bed depth affected the flame residence time significantly. The prediction model of flame length had better prediction effect, which could explain 83.3% of variance, with a mean absolute error of 7.8 cm and a mean relative error of 16.2%, while the prediction model of flame residence time was not good enough, which could only explain 54% of variance, with a mean absolute error of 9.2 s and a mean relative error of 18.6%.

  13. Injury profile SIMulator, a Qualitative aggregative modelling framework to predict injury profile as a function of cropping practices, and abiotic and biotic environment. II. Proof of concept: design of IPSIM-wheat-eyespot.

    Science.gov (United States)

    Robin, Marie-Hélène; Colbach, Nathalie; Lucas, Philippe; Montfort, Françoise; Cholez, Célia; Debaeke, Philippe; Aubertot, Jean-Noël

    2013-01-01

    IPSIM (Injury Profile SIMulator) is a generic modelling framework presented in a companion paper. It aims at predicting a crop injury profile as a function of cropping practices and abiotic and biotic environment. IPSIM's modelling approach consists of designing a model with an aggregative hierarchical tree of attributes. In order to provide a proof of concept, a model, named IPSIM-Wheat-Eyespot, has been developed with the software DEXi according to the conceptual framework of IPSIM to represent final incidence of eyespot on wheat. This paper briefly presents the pathosystem, the method used to develop IPSIM-Wheat-Eyespot using IPSIM's modelling framework, simulation examples, an evaluation of the predictive quality of the model with a large dataset (526 observed site-years) and a discussion on the benefits and limitations of the approach. IPSIM-Wheat-Eyespot proved to successfully represent the annual variability of the disease, as well as the effects of cropping practices (Efficiency = 0.51, Root Mean Square Error of Prediction = 24%; bias = 5.0%). IPSIM-Wheat-Eyespot does not aim to precisely predict the incidence of eyespot on wheat. It rather aims to rank cropping systems with regard to the risk of eyespot on wheat in a given production situation through ex ante evaluations. IPSIM-Wheat-Eyespot can also help perform diagnoses of commercial fields. Its structure is simple and permits to combine available knowledge in the scientific literature (data, models) and expertise. IPSIM-Wheat-Eyespot is now available to help design cropping systems with a low risk of eyespot on wheat in a wide range of production situations, and can help perform diagnoses of commercial fields. In addition, it provides a proof of concept with regard to the modelling approach of IPSIM. IPSIM-Wheat-Eyespot will be a sub-model of IPSIM-Wheat, a model that will predict injury profile on wheat as a function of cropping practices and the production situation.

  14. ¿Es redundante la prueba de selectividad?.

    Directory of Open Access Journals (Sweden)

    Rúa Vieytes, Antonio.

    2003-01-01

    Full Text Available Como consecuencia de la futura reforma en las pruebas de acceso a la universidad española, en donde la principal novedad será la eliminación de la prueba de conjunto o selectividad, cabe reflexionar sobre tan controvertida prueba y preguntarnos si realmente dicha prueba ha servido para algo y su aplicación ha sido efectiva en el rendimiento del alumno una vez dentro de la universidad o, por el contrario, si se trata de una prueba redundante. A partir del expediente académico y de las notas de selectividad de una muestra de 2.500 alumnos durante siete años, se llevará a cabo un análisis econométrico del grado de explicación que estas notas tienen sobre la prueba de conjunto y se constatará si dicha prueba es efectiva o redundante.

  15. Urban agriculture and Anopheles habitats in Dar es Salaam, Tanzania.

    Science.gov (United States)

    Dongus, Stefan; Nyika, Dickson; Kannady, Khadija; Mtasiwa, Deo; Mshinda, Hassan; Gosoniu, Laura; Drescher, Axel W; Fillinger, Ulrike; Tanner, Marcel; Killeen, Gerry F; Castro, Marcia C

    2009-05-01

    A cross-sectional survey of agricultural areas, combined with routinely monitored mosquito larval information, was conducted in urban Dar es Salaam, Tanzania, to investigate how agricultural and geographical features may influence the presence of Anopheles larvae. Data were integrated into a geographical information systems framework, and predictors of the presence of Anopheles larvae in farming areas were assessed using multivariate logistic regression with independent random effects. It was found that more than 5% of the study area (total size 16.8 km2) was used for farming in backyard gardens and larger open spaces. The proportion of habitats containing Anopheles larvae was 1.7 times higher in agricultural areas compared to other areas (95% confidence interval = 1.56-1.92). Significant geographic predictors of the presence of Anopheles larvae in gardens included location in lowland areas, proximity to river, and relatively impermeable soils. Agriculture-related predictors comprised specific seedbed types, mid-sized gardens, irrigation by wells, as well as cultivation of sugar cane or leafy vegetables. Negative predictors included small garden size, irrigation by tap water, rainfed production and cultivation of leguminous crops or fruit trees. Although there was an increased chance of finding Anopheles larvae in agricultural sites, it was found that breeding sites originated by urban agriculture account for less than a fifth of all breeding sites of malaria vectors in Dar es Salaam. It is suggested that strategies comprising an integrated malaria control effort in malaria-endemic African cities include participatory involvement of farmers by planting shade trees near larval habitats.

  16. II Jornadas sobre Emprendimiento Social y Colectivo

    OpenAIRE

    Centro de Investigación en Gestión de Empresas

    2013-01-01

    La línea temática principal del encuentro es el emprendimiento social y colectivo así como las diferentes líneas de investigación de los institutos y centros de la Red relacionadas, como: responsabilidad social, empleo y reincorporación al trabajo, inserción laboral, servicios sociales y dependencia, género, cambios legislativos, utilidad social, medio ambiente, desarrollo local,... Centro de Investigación en Gestión de Empresas (2013). II Jornadas sobre Emprendimiento Social y Colectivo. ...

  17. Effect of solvent on cocrystallization of Es2+ with SrCl2

    International Nuclear Information System (INIS)

    Mikheev, N.B.; Veleshko, I.E.; Kulyukhin, S.A.

    1994-01-01

    Complexation of Es 2+ with tetraphenylborate (BPh 4 - ) in acetonitrile (CH 3 CN) and tetrahydrofuran (THF) is studied by cocrystallization. The dependence of the cocrystallization coefficients of Es 2+ on [LiBPh 4 ] demonstrated that in THF, in contrast with CH 3 CN, Es 2+ is not complexed by BPh 4 . The stability constants β 1 and β 2 of the Es 2+ -BPh 4 complexes are 6.6 and 16.0, respectively, in CH 3 CN

  18. Learn OpenGL ES for mobile game and graphics development

    CERN Document Server

    Mehta, Prateek

    2013-01-01

    One of the first OpenGL ES version 3 books for game app developers doing mobile. Covers Android code and may be useful to iOS game developers too. OpenGL ES 3 is a new significant tech update to OpenGL ES graphics API engine that fuels game apps in both iOS and Android.

  19. Evaluation of the ES-2re Dummy in Biofidelity, Component, and Full Vehicle Crash Tests.

    Science.gov (United States)

    Sutterfield, Aleta; Pecoraro, Katie; Rouhana, Stephen W; Xu, Lan; Abramczyk, Joe; Berliner, Jeff; Irwin, Annette; Jensen, Jack; Mertz, Harold J; Nusholtz, Guy; Pietsch, Hollie; Scherer, Risa; Tylko, Suzanne

    2005-11-01

    This technical paper presents the results from tests conducted with the ES-2re, a version of the ES-2 side impact dummy that was modified by the National Highway Traffic Safety Administration (NHTSA) to improve its performance in crash tests. Through the series of biofidelity tests conducted on the ES-2re, described in International Standards Organization (ISO) Technical Report (TR)9790 (1999), the OSRP observed a final overall biofidelity ranking of 4.1 for the ES-2re, which corresponds to an ISO classification of "marginal." The biofidelity of the ES-2re is compared to that of the ES-2 and the WorldSID. Repeatability was also evaluated on the ES-2re based on the biofidelity test data. Additional pendulum tests were performed to assess the response of the dummy in oblique loading conditions, and results indicate that oblique loading from the front leads to significantly reduced rib deflections. To evaluate inconsistencies observed in the response of the ES-2, the OSRP analyzed the shoulder biofidelity via additional sled and drop tests. Due to the shoulder design of the ES-2 and ES-2re, the dummies appear to have significant sensitivity to initial conditions, potentially increasing variability in full vehicle tests. Finally, the responses of the ES-2re in full vehicle tests are compared to those of the ES-2 and the WorldSID.

  20. 76 FR 44906 - Foremost 4809-ES Insect-O-Fog; Amended Cancellation Order

    Science.gov (United States)

    2011-07-27

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-1017; FRL-8880-8] Foremost 4809-ES Insect-O-Fog... cancellation order for the pesticide product Foremost 4809-ES Insect-O-Fog, a pesticide product containing Piperonyl Butoxide and Pyrethrins. The registrant of Foremost 4809-ES Insect-O-Fog--Delta Foremost Chemical...

  1. Differential T-cell recognition of native and recombinant Mycobacterium tuberculosis GroES

    DEFF Research Database (Denmark)

    Rosenkrands, I; Weldingh, K; Ravn, P

    1999-01-01

    Mycobacterium tuberculosis GroES was purified from culture filtrate, and its identity was confirmed by immunoblot analysis and N-terminal sequencing. Comparing the immunological recognition of native and recombinant GroES, we found that whereas native GroES elicited a strong proliferative response...

  2. Application Programming in AWIPS II

    Science.gov (United States)

    Smit, Matt; McGrath, Kevin; Burks, Jason; Carcione, Brian

    2012-01-01

    Since its inception almost 8 years ago, NASA's Short-term Prediction Research and Transition (SPoRT) Center has integrated NASA data into the National Weather Service's decision support system (DSS) the Advanced Weather Interactive Processing System (AWIPS). SPoRT has, in some instances, had to shape and transform data sets into various formats and manipulate configurations to visualize them in AWIPS. With the advent of the next generation of DSS, AWIPS II, developers will be able to develop their own plugins to handle any type of data. Raytheon is developing AWIPS II to be a more extensible package written mainly in Java, and built around a Service Oriented Architecture. A plugin architecture will allow users to install their own code modules, and (if all the rules have been properly followed) they will work hand-in-hand with AWIPS II as if it were originally built in. Users can bring in new datasets with existing plugins, tweak plugins to handle a nuance or desired new functionality, or create an entirely new visualization layout for a new dataset. SPoRT is developing plugins to ensure its existing NASA data will be ready for AWIPS II when it is delivered, and to prepare for the future of new instruments on upcoming satellites.

  3. Type-II Weyl semimetals.

    Science.gov (United States)

    Soluyanov, Alexey A; Gresch, Dominik; Wang, Zhijun; Wu, QuanSheng; Troyer, Matthias; Dai, Xi; Bernevig, B Andrei

    2015-11-26

    Fermions--elementary particles such as electrons--are classified as Dirac, Majorana or Weyl. Majorana and Weyl fermions had not been observed experimentally until the recent discovery of condensed matter systems such as topological superconductors and semimetals, in which they arise as low-energy excitations. Here we propose the existence of a previously overlooked type of Weyl fermion that emerges at the boundary between electron and hole pockets in a new phase of matter. This particle was missed by Weyl because it breaks the stringent Lorentz symmetry in high-energy physics. Lorentz invariance, however, is not present in condensed matter physics, and by generalizing the Dirac equation, we find the new type of Weyl fermion. In particular, whereas Weyl semimetals--materials hosting Weyl fermions--were previously thought to have standard Weyl points with a point-like Fermi surface (which we refer to as type-I), we discover a type-II Weyl point, which is still a protected crossing, but appears at the contact of electron and hole pockets in type-II Weyl semimetals. We predict that WTe2 is an example of a topological semimetal hosting the new particle as a low-energy excitation around such a type-II Weyl point. The existence of type-II Weyl points in WTe2 means that many of its physical properties are very different to those of standard Weyl semimetals with point-like Fermi surfaces.

  4. Gene expression profiles in stages II and III colon cancers

    DEFF Research Database (Denmark)

    Thorsteinsson, Morten; Kirkeby, Lene T; Hansen, Raino

    2012-01-01

    PURPOSE: A 128-gene signature has been proposed to predict outcome in patients with stages II and III colorectal cancers. In the present study, we aimed to reproduce and validate the 128-gene signature in external and independent material. METHODS: Gene expression data from the original material...... were retrieved from the Gene Expression Omnibus (GEO) (n¿=¿111) in addition to a Danish data set (n¿=¿37). All patients had stages II and III colon cancers. A Prediction Analysis of Microarray classifier, based on the 128-gene signature and the original training set of stage I (n¿=¿65) and stage IV (n...... correctly predicted as stage IV-like, and the remaining patients were predicted as stage I-like and unclassifiable, respectively. Stage II patients could not be stratified. CONCLUSIONS: The 128-gene signature showed reproducibility in stage III colon cancer, but could not predict recurrence in stage II...

  5. A Hubble Space Telescope Survey for Novae in M87. II. Snuffing out the Maximum Magnitude–Rate of Decline Relation for Novae as a Non-standard Candle, and a Prediction of the Existence of Ultrafast Novae

    Energy Technology Data Exchange (ETDEWEB)

    Shara, Michael M.; Doyle, Trisha; Zurek, David [Department of Astrophysics, American Museum of Natural History, Central Park West and 79th Street, New York, NY 10024-5192 (United States); Lauer, Tod R. [National Optical Astronomy Observatory, P.O. Box 26732, Tucson, AZ 85726 (United States); Baltz, Edward A. [KIPAC, SLAC, 2575 Sand Hill Road, M/S 29, Menlo Park, CA 94025 (United States); Kovetz, Attay [School of Physics and Astronomy, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv (Israel); Madrid, Juan P. [CSIRO, Astronomy and Space Science, P.O. Box 76, Epping, NSW 1710 (Australia); Mikołajewska, Joanna [N. Copernicus Astronomical Center, Polish Academy of Sciences, Bartycka 18, PL 00-716 Warsaw (Poland); Neill, J. D. [California Institute of Technology, 1200 East California Boulevard, MC 278-17, Pasadena CA 91125 (United States); Prialnik, Dina [Department of Geosciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978 (Israel); Welch, D. L. [Department of Physics and Astronomy, McMaster University, Hamilton, L8S 4M1, Ontario (Canada); Yaron, Ofer [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, 76100 Rehovot (Israel)

    2017-04-20

    The extensive grid of numerical simulations of nova eruptions from the work of Yaron et al. first predicted that some classical novae might significantly deviate from the Maximum Magnitude–Rate of Decline (MMRD) relation, which purports to characterize novae as standard candles. Kasliwal et al. have announced the observational detection of a new class of faint, fast classical novae in the Andromeda galaxy. These objects deviate strongly from the MMRD relationship, as predicted by Yaron et al. Recently, Shara et al. reported the first detections of faint, fast novae in M87. These previously overlooked objects are as common in the giant elliptical galaxy M87 as they are in the giant spiral M31; they comprise about 40% of all classical nova eruptions and greatly increase the observational scatter in the MMRD relation. We use the extensive grid of the nova simulations of Yaron et al. to identify the underlying causes of the existence of faint, fast novae. These are systems that have accreted, and can thus eject, only very low-mass envelopes, of the order of 10{sup −7}–10{sup −8} M {sub ⊙}, on massive white dwarfs. Such binaries include, but are not limited to, the recurrent novae. These same models predict the existence of ultrafast novae that display decline times, t {sub 2,} to be as short as five hours. We outline a strategy for their future detection.

  6. El museo deslumbrante - II

    Directory of Open Access Journals (Sweden)

    Fernando Arbeláez

    1964-06-01

    Full Text Available Es cierto que he venido para ver a Grecia, pero también es cierto que no es posible tratar de acercarse a ella, sin ir a esos desapacibles lugares que llamamos museos. Y hay todo un programa en Atenas: el Museo Arqueológico Nacional, el Museo Bizantino, el Museo Benaki, el Museo de Arte Popular, el Museo Etnológico, el Ágora y la Acrópolis. Esto en el centro de la ciudad, porque también existen sus riquísimos alrededores, las ruinas bizantinas, las modernas catedrales, Plaka y todos los barrio del norte con su espíritu y su encanto tan singulares. Además es necesario ir hasta el Pireo y gozar de su embrujo nocturno a más de visitar el famoso museo. He descifrado la dirección de un ómnibus : Eleusis.

  7. Femoral haemostasis with Vasoseal ES: experience in 150 patients; Emostasi femorale mediante Vasoseal ES: esperienza in 150 pazienti

    Energy Technology Data Exchange (ETDEWEB)

    Gazzera, Carlo; Doriguzzi Breatta, Andrea; Veltri, Andrea; Righi, Dorico; Barbero, Stefano; Balderi, Alberto; Petracchni, Massimo; Gandini, Giovanni [Ospedale San Giovanni Battista, Torino (Italy); Torino Univ., Torino (Italy). Istituto di Radiologia

    2005-02-01

    Purpose: The aim of this study is to assess the effectiveness and safety of the use of Vasoseal ES collagen plug in heavenly anti coagulated patients with risk of complications at the vascular access site who had undergone vascular radiological intervention. Materials and methods: Between January 2002 and March 2003 180 consecutive transfemoral arterial accesses in 169 patients subjected to vascular radiological procedures were performed (bilateral access was performed in 11 patients): 140 percutaneous transluminal angioplasties and 40 transarterial chemoembolisations. All the patients who underwent angioplasty were given 3,000 IU of sodic heparin intravenously during the procedure and later a prolonged antiaggregant therapy was undertaken (ticlopidine 500 mg/day and aspirin 150 mg/day). The sheaths were removed at the end of the surgical manoeuvre and two cartridges of collagen were positioned on the external surface of the artery. The mean values of platelets and partial thromboplastin time were 42,000/ml and 170 s, respectively, in cirrhotic patients against 250,000/ml and 200 s in patients with peripheral arteriopathy. The next day a colour Doppler examination was performed at the puncture site. Results: The technique proved successful in 89.4% of cases (161/180). In 19/180 vascular accesses placement of the haemostatic cartridges was not possible owing to the inability to compress the common femoral artery proximal to the release site (4/19), owing to a pre-existing haematoma (5/19) and owing to the limited presence of subcutoma (5/19) and owing to the limited presence of subcutaneous tissue (10/19). The mean time required for the placement of Vasoseal ES was 4 min. The mean time to haemostasis was 6 min. The mean time to mobilisation was 4 hr. Only in two patients was there an onset of a pseudoaneurysm of the right common femoral artery-, the lesions were treated with ultrasonography-guided compression. In addition, 16 small local haematomas were recorded. In

  8. ¿Cuál es el objetivo principal de la mercadotecnia?

    OpenAIRE

    Francisco Gerardo Barroso Tanoira

    2008-01-01

    Hay quienes piensan que el objetivo principal de la mercadotecnia es vender más, o bien, colocar productos y distribuirlos, o que es una herramienta para atraer a los clientes o inclusive para manipularlos. El objetivo del presente ensayo es reflexionar sobre el objetivo principal de esta disciplina, la cual es realmente una filosofía de vida empresarial. Se concluye que dicho objetivo es fomentar el intercambio voluntario entre dos o más partes que tienen algo que interesa a unos y a otros e...

  9. Calage de la partie congestionnée du diagramme fondamental combinant données de boucles et données FCD

    OpenAIRE

    CLAIRAIS, Aurélien

    2015-01-01

    Malgré l'essor des données FCD, comme les données GPS, il n'existe pas de méthode de calage de diagramme fondamental basée sur ce type de données. Le rapport propose une méthode de calage al- liant données de boucles electromagnétiques et données FCD. La méthode est développée pour un tronçon simple sans entrée ni sortie. Le modèle utilisé est le modèle LWR associé à un diagramme fondamental triangulaire. La première partie donne une méthode pour simuler un front d'onde de congestion et des t...

  10. [es] Los conocimientos en trabajo social: elogio del eclecticismo

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Deslauriers

    2010-06-01

    Full Text Available La ciencia está en el origen del trabajo social. En efecto, el objetivo que perseguía Mary Richmond al conceptualizar la disciplina de trabajo social consistía en reemplazar las creencias religiosas por un enfoque racional. Así pues, el conocimiento científico se inscribe en el corazón del trabajo social desde el principio. Dicho esto, las grandes teorías son menos útiles en la práctica de una profesión cuya finalidad es ayudar a las personas que viven las situaciones más diversas. Esta es la razón por la cual el trabajo social se construye a partir de una base ecléctica: el trabajador social eficaz toma de un vasto conjunto de nociones, en apariencia dispares, aquellas que mejor se adaptan a la situación. Ahora bien, ¿cómo enseñar este conocimiento práctico a los estudiantes de trabajo social? Este artículo trata de estas cuestiones y propone algunas pistas de reflexión. Science is closely related to social work, from its very origin. In fact, with the conceptualization of social work, Mary Richmond’s objective was to replace religious beliefs by a more rational approach. Thus, right from its beginning, the scientific knowledge was at the core of social work. This being said, grand theories are less appropriate to the practice of social work because this profession deals with persons living in particular situations. That is why social work is built upon an eclectic basis : social worker has to draw from a vast array of notions and theories to borrow bits and pieces which will help to explain and attenuate problem experienced by persons. Now, this practical knowledge can be taught to students in social work? This article deals with these questions and proposes some reflections.

  11. Advances in SELEX ES infrared detectors for space and astronomy

    Science.gov (United States)

    Knowles, P.; Hipwood, L.; Baker, I.; Weller, H.

    2017-11-01

    Selex ES produces a wide range of infrared detectors from mercury cadmium telluride (MCT) and triglycine sulfate (TGS), and has supplied both materials into space programmes spanning a period of over 40 years. Current development activities that underpin potential future space missions include large format arrays for near- and short-wave infrared (NIR and SWIR) incorporating radiation-hard designs and suppression of glow. Improved heterostructures are aimed at the reduction of dark currents and avalanche photodiodes (APDs), and parallel studies have been undertaken for low-stress MCT array mounts. Much of this development work has been supported by ESA, UK Space, and ESO, and some has been performed in collaboration with the UK Astronomy Technology Centre and E2V. This paper focuses on MCT heterostructure developments and novel design elements in silicon read-out chips (ROICs). The 2048 x 2048 element, 17um pitch ROIC for ESA's SWIR array development forms the basis for the largest cooled infrared detector manufactured in Europe. Selex ES MCT is grown by metal organic vapour phase epitaxy (MOVPE), currently on 75mm diameter GaAs substrates. The MCT die size of the SWIR array is 35mm square and only a single array can be printed on the 75mm diameter wafer, utilising only 28% of the wafer area. The situation for 100mm substrates is little better, allowing only 2 arrays and 31% utilisation. However, low cost GaAs substrates are readily available in 150mm diameter and the MCT growth is scalable to this size, offering the real possibility of 6 arrays per wafer with 42% utilisation. A similar 2k x 2k ROIC is the goal of ESA's NIR programme, which is currently in phase 2 with a 1k x 1k demonstrator, and a smaller 320 x 256 ROIC (SAPHIRA) has been designed for ESO for the adaptive optics application in the VLT Gravity instrument. All 3 chips have low noise source-follower architecture and are enabled for MCT APD arrays, which have been demonstrated by ESO to be capable of

  12. (II) COMPLEX COMPOUND

    African Journals Online (AJOL)

    user

    electrochemical sensors, as well as in various chromatographic ... were carried out using Jenway pH meter Model 3320 and a conductivity ... Figure 1: the proposed molecular structure of the copper (II) Schiff base complex. M = Cu (II) or Mn (II).

  13. and copper(II)

    Indian Academy of Sciences (India)

    Unknown

    (II) and copper(II)–zinc(II) complexes. SUBODH KUMAR1, R N PATEL1*, P V KHADIKAR1 and. K B PANDEYA2. 1 Department of Chemistry, APS University, Rewa 486 003, India. 2 CSJM University, Kanpur 208 016, India e-mail: (R N Patel) ...

  14. Usefulness of the admission electrocardiogram to predict long-term outcomes after non-ST-elevation acute coronary syndrome (from the FRISC II, ICTUS, and RITA-3 [FIR] Trials).

    Science.gov (United States)

    Damman, Peter; Holmvang, Lene; Tijssen, Jan G P; Lagerqvist, Bo; Clayton, Tim C; Pocock, Stuart J; Windhausen, Fons; Hirsch, Alexander; Fox, Keith A A; Wallentin, Lars; de Winter, Robbert J

    2012-01-01

    The aim of this study was to evaluate the independent prognostic value of qualitative and quantitative admission electrocardiographic (ECG) analysis regarding long-term outcomes after non-ST-segment elevation acute coronary syndromes (NSTE-ACS). From the Fragmin and Fast Revascularization During Instability in Coronary Artery Disease (FRISC II), Invasive Versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS), and Randomized Intervention Trial of Unstable Angina 3 (RITA-3) patient-pooled database, 5,420 patients with NSTE-ACS with qualitative ECG data, of whom 2,901 had quantitative data, were included in this analysis. The main outcome was 5-year cardiovascular death or myocardial infarction. Hazard ratios (HRs) were calculated with Cox regression models, and adjustments were made for established outcome predictors. The additional discriminative value was assessed with the category-less net reclassification improvement and integrated discrimination improvement indexes. In the 5,420 patients, the presence of ST-segment depression (≥1 mm; adjusted HR 1.43, 95% confidence interval [CI] 1.25 to 1.63) and left bundle branch block (adjusted HR 1.64, 95% CI 1.18 to 2.28) were independently associated with long-term cardiovascular death or myocardial infarction. Risk increases were short and long term. On quantitative ECG analysis, cumulative ST-segment depression (≥5 mm; adjusted HR 1.34, 95% CI 1.05 to 1.70), the presence of left bundle branch block (adjusted HR 2.15, 95% CI 1.36 to 3.40) or ≥6 leads with inverse T waves (adjusted HR 1.22, 95% CI 0.97 to 1.55) was independently associated with long-term outcomes. No interaction was observed with treatment strategy. No improvements in net reclassification improvement and integrated discrimination improvement were observed after the addition of quantitative characteristics to a model including qualitative characteristics. In conclusion, in the FRISC II, ICTUS, and RITA-3 NSTE-ACS patient-pooled data set

  15. High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition

    International Nuclear Information System (INIS)

    Klein-Scory, Susanne; Zapatka, Marc; Eilert-Micus, Christina; Hoppe, Sabine; Schwarz, Elisabeth; Schmiegel, Wolff; Hahn, Stephan A; Schwarte-Waldhoff, Irmgard

    2007-01-01

    Smad4 is a tumour suppressor frequently inactivated in pancreatic and colorectal cancers. We have recently reported loss of Smad4 in every fourth carcinoma of the uterine cervix. Smad4 transmits signals from the TGF-β superfamily of cytokines and functions as a versatile transcriptional co-modulator. The prevailing view suggests that the tumour suppressor function of Smad4 primarily resides in its capability to mediate TGF-β growth inhibitory responses. However, accumulating evidence indicates, that the acquisition of TGF-β resistance and loss of Smad4 may be independent events in the carcinogenic process. Through inducible reexpression of Smad4 in cervical cancer cells we wished to shed more light on this issue and to identify target genes implicated in Smad4 dependent tumor suppression. Smad4-deficient human C4-II cervical carcinoma cells were used to establish inducible Smad4 reexpression using the commercial Tet-on™ system (Clontech). The impact of Smad4 reexpression on cell growth was analysed in vitro and in vivo. Transcriptional responses were assessed through profiling on cDNA macroarrays (Clontech) and validated through Northern blotting. Clones were obtained that express Smad4 at widely varying levels from approximately physiological to 50-fold overexpression. Smad4-mediated tumour suppression in vivo was apparent at physiological expression levels as well as in Smad4 overexpressing clones. Smad4 reexpression in a dose-dependent manner was associated with transcriptional induction of the extracellular matrix-associated genes, BigH3, fibronectin and PAI-1, in response to TGF-β. Smad4-dependent regulation of these secreted Smad4 targets is not restricted to cervical carcinoma cells and was confirmed in pancreatic carcinoma cells reexpressing Smad4 after retroviral transduction and in a stable Smad4 knockdown model. On the other hand, the classical cell cycle-associated TGF-β target genes, c-myc, p21 and p15, remained unaltered. Our results show that

  16. MicroRNA expression characterizes oligometastasis(es).

    Science.gov (United States)

    Lussier, Yves A; Xing, H Rosie; Salama, Joseph K; Khodarev, Nikolai N; Huang, Yong; Zhang, Qingbei; Khan, Sajid A; Yang, Xinan; Hasselle, Michael D; Darga, Thomas E; Malik, Renuka; Fan, Hanli; Perakis, Samantha; Filippo, Matthew; Corbin, Kimberly; Lee, Younghee; Posner, Mitchell C; Chmura, Steven J; Hellman, Samuel; Weichselbaum, Ralph R

    2011-01-01

    Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤ 5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy. Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy. Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression. These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.

  17. JUVENTUDE E POBREZA: IMPLICAÇÕES PSICOSSOCIAIS DO FATALISMO

    Directory of Open Access Journals (Sweden)

    Verônica Morais Ximenes

    2016-01-01

    Full Text Available Este estudio cualitativo realizado en la ciudad de Fortaleza (Ceará/Brasil pretende analizar las manifestaciones del fatalismo de jóvenes en condiciones de pobreza. El fatalismo representa un fenómeno psicosocial asociado al aparente conformismo de los individuos ante las situaciones de opresión r ecurrentes de la pobreza. Se realizar o n dos grupos focales , con 12 participantes jóvenes que se encontraban en situación de pobreza. L as manifestaciones del fatalismo congregaban: creencia s en el éxito como resulta do del esfuerzo individual y de la voluntad divina; construcción de propósitos de vida sujet os a las aspiraciones personales; calma aparente; silenciamiento y aleja miento emocional. Es el clima de incertidumbre e indefinición de una vida marcada por la pobreza la que refuerza el fatalismo, siendo neces a rio emprender caminos libertarios para la juventud pobre.

  18. GRAVIDADE DE INTOXICAÇÕES POR SANEANTES CLANDESTINOS

    Directory of Open Access Journals (Sweden)

    Jessica Adrielle Teixeira Santos

    2011-01-01

    Full Text Available El presente estudio tuvo como objetivo analizar las intoxicaciones por saneantes comercializados clandestinamente, reportadas en el Centro de Control de Intoxicaciones del Hospital Universitario Regional de Maringá. Es un estudio cuantitativo, con análisis retrospectivo de registros epidemiológicos de personas intoxicadas por estos agentes, en el período de enero de 2005 a diciembre de 2009. De los 118 casos reportados, la mayoría (74-62,7% se produjeron en varones, 105 (88,9% necesitaron de asistencia en unidades de atención de emergencia y hospitalización de alta complejidad, en 14 casos (11,8% requirieron de Cuidados Intensivos, y se reportaron cinco óbitos, todos por intoxicación intencional. Los resultados demuestran la gravedad y la letalidad de este tipo de intoxicación, sugieren la necesidad de medidas urgentes de fiscalización y control de la Vigilancia Sanitaria, así como de medidas para la educación de los consumidores, haciendo hincapié en el papel educativo de la Enfermería

  19. VOLTA REDONDA: IMPLICAÇÕES PARA A ENFERMAGEM

    Directory of Open Access Journals (Sweden)

    Ana Emília Cardoso Moraes

    2010-01-01

    Full Text Available Este estudio tuvo como objetivo la intervención en la Casa de Saúde Volta Redonda y sus implicaciones para la enfermería psiquiátrica. Las fuentes históricas son documentos escritos y orales. La organización, clasificación y análisis de los datos se hizo según el método histórico, con el apoyo de los conceptos de habitus y campo de Pierre Bourdieu y de la bibliografía sobre la reforma psiquiátrica en Brasil. Los cambios en la política de salud mental exigieron nuevas prácticas y actitudes de acuerdo con el proceso de implementación de la reforma psiquiátrica en aquel municipio, cuyo pilar es la inserción del enfermo psiquiátrico en la comunidad y el rescate de su ciudadanía. Estas medidas forman parte de un proyecto político partidario más amplio, con experiencias en otros municipios brasileños. La Enfermería ha ganado posiciones de poder y visibilidad para asegurar su participación en diferentes espacios decisorios en el ámbito de la asistencia psiquiátrica en el municipio.

  20. SRS ES ampersand H standards compliance program management plan

    International Nuclear Information System (INIS)

    Hearn, W.H.

    1993-01-01

    On March 8, 1990, the Defense Nuclear Facilities Safety Board (DNFSB) issued Recommendation 90-2 to the Secretary of Energy. This recommendation, based upon the DNFSB's initial review and evaluation of the content and implementation of standards relating to the design, construction, operations, and decommissioning of defense nuclear facilities of the Department of Energy (DOE), called for three actions: (1) identification of specific standards that apply to design, construction, operation and decommissioning of DOE facilities; (2) assessment of the adequacy of those standards for protecting public health and safety; and (3) determination of the extent to which they have and are being implemented. This document defines the elements of the SRS program required to support the HQ program in response to DNFSB Recommendation 90-2. The objective is to ensure a consistent approach for all sitewide ES and H Standards Compliance Program efforts that satisfied the intent of Recommendation 90-2 and the HQ 90-2 Implementation Plan in a cost-effective manner. The methodology and instructions for implementation of the SRS program are contained in the Standards Compliance Program Implementation Plan. The Management Plan shall be used in conjunction with the Implementation Plan

  1. ¿Qué es una institución?

    Directory of Open Access Journals (Sweden)

    John R. Searle

    2006-09-01

    Full Text Available Cuando era un estudiante universitario en Oxford, nos enseñaban economía como si fuera una ciencia natural. La materia objeto de la economía podría ser diferente de la física, pero sólo en la medida en la que el contenido de la química o la biología son diferentes de la física. Los resultados propiamente dichos nos fueron presentados como si fuesen teorías científicas. Por ello cuando aprendimos que los ahorros equivalen a la inversión, se nos enseñaba en el mismo tono de voz en el que uno aprende que la fuerza es igual a la masa por la aceleración. Y aprendimos que los empresarios juiciosos venden cuando el coste marginal iguala al beneficio marginal de la misma manera en la que una vez aprendimos que los cuerpos se atraen con una fuerza directamente proporcional al producto de sus masas e inversamente proporcional al cuadrado de la distancia que los separa. En ningún momento se planteó que la realidad descrita por la teoría económica fuera dependiente de las creencias y otras actitudes humanas de una manera que era completamente distinta de la realidad descrita por la física o la química.

  2. ¿Qué es la “Chalandisation”?

    Directory of Open Access Journals (Sweden)

    Michel Chauvière

    2011-06-01

    Full Text Available Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4 En este artículo se estudian los procedimientos mediante los cuales el sector social se ve sometido a la llamada “chalandisation”, término francés de difícil traducción al castellano que indica el modo de gestión general de nuestras sociedades tardomodernas, postkeynesianas. Constataremos cómo esta lógica modifica la ordenación del campo de lo social, su modo de financiación, así como el sentido que los actores del terreno dan a su trabajo. Se analizará este proceso general en curso a través de los cambios regulatorios acaecidos en Francia desde los años 80.This article explores the processes by which the social sector i ssubjected to the ‘chandalisation’, the French Word difficult to translate into Spanish that indicates how is the overall management of late-modern societies, Post Keynesian. We’ll see how this changes the spatial logic of the social field, its mode of financing, as well as the sense that actors give to their work site. It Will be analyzed the current general process through regulatory changes that occurred in France since the 80’s.

  3. Hydrodynamic Aspects at Vitória Bay Mouth, ES

    Directory of Open Access Journals (Sweden)

    FLÁVIA A.A. GARONCE

    2014-06-01

    Full Text Available Understading the hydrodynamic behavior and suspended particulated matter (SPM transport are of great importance in port regions such as Vitória Harbor, which is located at Vitória Bay, Vitória – ES, Brazil. Vitória Bay is an estuary that has not been systematically assessed through a temporal analysis in order to identify its hydrodynamics characteristics and SPM exchange. This study aims to investigate salt and suspended particulate matter flux at the estuarine mouth of Vitória Bay by understanding the temporal variation of salinity, temperature and tidal currents within the water column and at the channel crosssection. Results showed that the estuarine mouth tended to present partial stratification periods during neap tides and little stratification in spring tides. The circulation pattern was mainly influenced by the tide, with little influence from river discharge. With regard to the SPM, the mouth of the estuary tended to show low concentrations, with the highest values occurring during the dry season. A close relationship between momentary discharge, SPM and salt fluxes was observed. Despite all the data was collected at the mouth of the estuary, the system showed an importation trend of salt in all cycles and SPM importation for three of the four studied tidal cycles. Thus, Vitoria Bay is not exporting SPM to the adjacent inner shelf.

  4. MicroRNA expression characterizes oligometastasis(es.

    Directory of Open Access Journals (Sweden)

    Yves A Lussier

    Full Text Available Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤ 5 cumulative metastasis(es, termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy.Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy.Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression.These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.

  5. ¿Qué tan verde es tu mercado?

    Directory of Open Access Journals (Sweden)

    Wilmar R. Olaya-González

    2011-01-01

    Full Text Available El mercado de lo verde y lo ecológico es una tendencia indiscutible en nuestro mundo globalizado, que busca de alguna manera resarcir el daño infringido sobre el medio ambiente. Más allá de simple altruismo, la ecología se ha convertido en una moda, de la cual unos y otros toman ventaja a su mejor acomodo, haciendo del mercado de productos y servicios su tribuna; eco-diseño, planes de responsabilidad social y ambiental, campañas por el reciclaje y consumo de productos "más amigables" con el medio ambiente hacen parte del panorama que se intenta describir en esta reseña. Por medio de un estudio de caso, se hará énfasis en cómo la comunicación asume un papel crucial en la verdadera apropiación del concepto de "consumidor verde" y "consumidor responsable", de manera que la propuesta transversal de las tic se convierta en una herramienta no solo tecnológica, sino también de empoderamiento del papel que la sociedad puede representar en el cuidado de los recursos naturales.

  6. La televisión Colombia es de autor

    Directory of Open Access Journals (Sweden)

    Omar Rincón

    2015-05-01

    Full Text Available Colombia tiene una marca narrativa en televisión. Somos el país de Yo soy Betty, la fea y Café con aroma de mujer y por eso Fernando Gaitán es nuestro gran contador cultural, así como lo fue antes García Márquez y su realismo mágico o Botero y sus gorditos divertidos. Nuestra marca Colombia de ficción televisiva se caracteriza por ser esa que hace otro melodrama e intenta otras éticas y estéticas, que innova y emociona distinto. Una ficción de autor. Eso comenzó desde el 13 de junio de 1954 cuando se inauguró la pequeña pantalla para conmemorar el primer año de gobierno del general Rojas Pinilla. En la primera emisión El niño del pantano, una breve de ficción adaptada para televisión de un cuento original de Bernardo Romero Lozano, ya marcaba el rumbo. Desde ese primer día la televisión colombiana buscó ser una mezcla entre lo de élite y lo popular, entre el gran drama y la comedia.

  7. La lucidez es la herida mas cercana al sol

    Directory of Open Access Journals (Sweden)

    Juan E. Manuel Roca

    2015-01-01

    Full Text Available La comunicación interpersonal, muchas veces es dejada de lado por los comunicólogos, sin embargo tiene suma gravitación en las relaciones cotidianas entre las personas y en los procesos comunicacionales, toca el lenguaje de los gestos, la (in comunicación política, ceremonial y protocolo, intermediación en la comunicación, los jóvenes se incomunican. Respecto al Periodismo Investigativo señala que a pesar de los riesgos que implica el periodismo investigativo, muchos profesionales de América Latina no dudan en practicarlo, escudriñando muchas veces en temas que de no ser por ellos permanecerían ocultos. En otro artículo se habla de la importante repercusión que tuvo en América Latina el concurso CHASQUI, el que contó con la participación de profesionales de todo el continente. Incluye la entrega de entrevistas a destacados comunicadores de América Latina. Una sección está dedicada a las nuevas tecnologías: red de noticias y transmisiones vía satélite.

  8. Chinese mitten crab (Eriocheir sinensis) iron-sulphur cluster assembly protein 2 (EsIscA2) is differentially regulated after immune and oxidative stress challenges.

    Science.gov (United States)

    Zhang, Peng; Liu, Yu; Wang, Min; Dong, Miren; Liu, Zhaoqun; Jia, Zhihao; Wang, Weilin; Zhang, Anguo; Wang, Lingling; Song, Linsheng

    2018-07-01

    Iron-sulphur clusters (ISCs), one of the oldest and most versatile cofactors of proteins, are involved in catalysis reactions, electron transport reactions, regulation processes as well as sensing of ambient conditions. Iron-sulphur cluster assembly protein (IscA) is a scaffold protein member of ISC formation system, which plays a significant role in the assembly and maturation process of ISC proteins. In the present study, the cDNA sequence of iron-sulphur cluster assembly protein 2 (designated as EsIscA2) was cloned from Eriocheir sinensis. The open reading frame (ORF) of EsIscA2 was of 507 bp, encoding a peptide of 168 amino acids with a typically conserved Fe-S domain. A tetrameric form was predicated by the SWISS-MODEL prediction algorithm, and three conserved cysteine residues (Cys-93, Cys-158, Cys-160) from each IscA monomer were predicted to form a 'cysteine pocket'. The deduced amino acid sequence of EsIscA2 shared over 50% similarity with that of other IscAs. EsIscA2 was clustered with IscA2 proteins from invertebrates and vertebrates, indicating that the protein was highly conservative in the evolution. rEsIscA2 exhibited a high iron binding affinity in the concentration ranging from 2 to 200 μM. EsIscA2 transcripts were detected in all the tested tissues including gonad, hemocytes, gill, muscle, heart, hepatopancreas and eyestalk, and EsIscA2 protein was detected in the mitochondria of hemocytes. The highest mRNA expression level of EsIscA2 was detected in muscle and hepatopancreas, which was about 34.66-fold (p < 0.05) and 27.07-fold (p < 0.05) of that in hemocytes, respectively. After Aeromonas hydrophila and lipopolysaccharide (LPS) stimulations, the mRNA expression of EsIscA2 in hemocytes was down-regulated and reached the lowest level at 24 h (0.31-fold, p < 0.05) and 48 h (0.29-fold, p < 0.05) compared to control group, respectively. And the expression of EsIscA2 mRNA in hepatopancreas was repressed from 6 h to 48 h post

  9. Mobilisations collectives et femmes immigrées en France

    Directory of Open Access Journals (Sweden)

    Sylvie Thiéblemont-Dollet

    2008-09-01

    Full Text Available Si nombreuses que soient les études ayant trait à l’immigration en France (et plus particulièrement masculine, aborder l’immigration sous l’angle des femmes immigrées et des processus communicationnels qu'elles ont développés en terre d’accueil est un apport essentiel aux sciences humaines. C’est pourquoi, cet article traite du thème de la mobilisation collective entre 2000 et 2008, par le biais des actions et des processus communicationnels mis en œuvre par des femmes immigrées ou issues de l’immigration, originaires du Maghreb et de l’Afrique de l’Ouest, plus particulièrement à partir de l’exemple du mouvement Ni Putes Ni Soumises. Analyser les réseaux d’interdépendance et de « contagion » entre ces actrices aux origines sociales identiques, faisant que ces femmes expriment un sentiment d’exclusion et associent leur statut social (chômage, profession sous-qualifiée, ethnique (origine maghrébine ou africaine et spatial (cité, banlieue, quartier dit difficile, à un même stigmate les reléguant à un univers discriminatoire, dégager les spécificités de leurs paroles selon les espaces et les temporalités où elles ont été délivrées, saisir leurs manières de s’organiser et leurs possibilités de mobilisation, sont les grands axes de cette réflexion. Suggérer enfin que ces femmes constituent un corps social émergent et mutant est une autre manière de lire ce texte. Émergent, parce qu’il est relativement récent du point de vue de sa visibilité dans la sphère publique et mutant, parce qu’il intègre des femmes qui participent d’un changement en train de se faire dans la société française et qui donnent une nouvelle image d’elles : non pas celle de féministes au sens classique du terme et de ce qui peut s’y rattacher, mais celle qui s’inscrit dans la perspective de comportement de genre à entendre comme mixité et modalités d’interaction entre femmes et hommes. Enfin

  10. Le groupe de recherches transfusionnelles d’Afrique francophone: bilan des cinq premières années

    Science.gov (United States)

    Tagny, Claude Tayou; Murphy, Edward L.; Lefrère, Jean-Jacques

    2016-01-01

    Les travaux de recherches sur la sécurité transfusionnelle en Afrique sub-saharienne sont peu nombreux, souvent limités à des initiatives locales avec des conclusions difficilement représentatives de cette région. Le Groupe de recherches transfusionnelles en Afrique sub-saharienne francophone a été créé en mai 2007 avec pour objectif de développer des stratégies globales d’amélioration de la sécurité transfusionnelle mais adaptables à la situation de chaque pays. Les activités du Groupe à ce jour ont porté essentiellement sur l’obtention de données épidémiologiques et de laboratoire sur la transfusion sanguine et à proposer des stratégies de sécurité transfusionnelle dans le domaine des infections transmissibles par la transfusion. Pour mener à bien ces activités de recherche, le Groupe travaille en étroite collaboration avec les Centres nationaux de transfusion sanguine (CNTS), les Centres régionaux de transfusion sanguine (CRTS), les banques de sang hospitalières (BSH) et les postes de collecte de sang. Pour les 5 premières années, quatre priorités de recherche ont été identifiées: (i) des études descriptives sur les caractéristiques des donneurs de sang et des centres de transfusion; (ii) une estimation du risque résiduel post-transfusionnel des principales infections virales transmissibles par la transfusion; (iii) une analyse des stratégies de sélection médicale des donneurs de sang; et (iv) une description des stratégies de dépistage des ITT et une description du système d’assurance qualité externe existant. Durant cette période, sept projets ont été mis en œuvre au niveau national et publiés et cinq études multicentriques ont été réalisées et publiées. La présente étude rapporte les principales observations et recommandations de ces études. PMID:24360798

  11. Pius II. a utrakvismus

    OpenAIRE

    Šimek, Milan

    2009-01-01

    Milan Šimek Pius II. a utrakvismus Pius II. and utraquism Based on sources work - out, the thesis aims the description and analysis of the attitude alternation of Enea Sylvio Piccolomini - Pius II to the utraquism. The conclusions stress the postulate that Pius II. did not change that attitude, but just did not succed in quelling the utraquist movement. In the sense of political background that finally led to fatal dissention among both leaders, king Jiří of Poděbrady and pope Pius II.

  12. Transport with Astra in TJ-II; Transporte con Astra en TJ-II

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Bruna, D; Castejon, F; Fontdecaba, J M

    2004-07-01

    This report describes the adaptation of the numerical transport shell ASTRA for performing plasma calculations in the TJ-II stellarator device. Firstly, an approximation to the TJ-II geometry is made and a simple transport model is shared with two other codes in order to compare these codes (PROCTR, PRETOR-Stellarator) with ASTRA as calculation tool for TJ-II plasmas are provided: interpretative and predictive transport. The first consists in estimating the transport coefficients from real experimental data, thes being taken from three TJ-II discharges. The predictive facet is illustrated using a model that is able to includes self-consistently thedynamics of transport barriers. The report includes this model, written in the ASTRA programming language, to illustrate the use of ASTRA. (Author) 26 refs.

  13. Earthquake prediction

    International Nuclear Information System (INIS)

    Ward, P.L.

    1978-01-01

    The state of the art of earthquake prediction is summarized, the possible responses to such prediction are examined, and some needs in the present prediction program and in research related to use of this new technology are reviewed. Three basic aspects of earthquake prediction are discussed: location of the areas where large earthquakes are most likely to occur, observation within these areas of measurable changes (earthquake precursors) and determination of the area and time over which the earthquake will occur, and development of models of the earthquake source in order to interpret the precursors reliably. 6 figures

  14. Complexes of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and dioxouranium(II) with thiophene-2-aldehydethiosemicarbazone

    International Nuclear Information System (INIS)

    Singh, Balwan; Misra, Harihar

    1986-01-01

    Metal complexes of thiosemicarbazides have been known for their pharmacological applications. Significant antitubercular, fungicidal and antiviral activities have been reported for thiosemicarbazides and their derivatives. The present study describes the systhesis and characterisation of complexes of Co II , Cu II , Zn II ,Cd II and UO II with thiosemicarbazone obtained by condensing thiophene-2-aldehyde with thiosemicarbazide. 17 refs., 2 tables. (author)

  15. Modeling Fe II Emission and Revised Fe II (UV) Empirical Templates for the Seyfert 1 Galaxy I Zw 1

    Science.gov (United States)

    Bruhweiler, F.; Verner, E.

    2008-03-01

    We use the narrow-lined broad-line region (BLR) of the Seyfert 1 galaxy, I Zw 1, as a laboratory for modeling the ultraviolet (UV) Fe II 2100-3050 Å emission complex. We calculate a grid of Fe II emission spectra representative of BLR clouds and compare them with the observed I Zw 1 spectrum. Our predicted spectrum for log [nH/(cm -3) ] = 11.0, log [ΦH/(cm -2 s-1) ] = 20.5, and ξ/(1 km s-1) = 20, using Cloudy and an 830 level model atom for Fe II with energies up to 14.06 eV, gives a better fit to the UV Fe II emission than models with fewer levels. Our analysis indicates (1) the observed UV Fe II emission must be corrected for an underlying Fe II pseudocontinuum; (2) Fe II emission peaks can be misidentified as that of other ions in active galactic nuclei (AGNs) with narrow-lined BLRs possibly affecting deduced physical parameters; (3) the shape of 4200-4700 Å Fe II emission in I Zw 1 and other AGNs is a relative indicator of narrow-line region (NLR) and BLR Fe II emission; (4) predicted ratios of Lyα, C III], and Fe II emission relative to Mg II λ2800 agree with extinction corrected observed I Zw 1 fluxes, except for C IV λ1549 (5) the sensitivity of Fe II emission strength to microturbulence ξ casts doubt on existing relative Fe/Mg abundances derived from Fe II (UV)/Mg II flux ratios. Our calculated Fe II emission spectra, suitable for BLRs in AGNs, are available at http://iacs.cua.edu/people/verner/FeII. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 05-26555.

  16. Theoretical predictions of properties and volatility of chlorides and oxychlorides of group-4 elements. II. Adsorption of tetrachlorides and oxydichlorides of Zr, Hf, and Rf on neutral and modified surfaces

    International Nuclear Information System (INIS)

    Pershina, V.; Borschevsky, A.; Iliaš, M.; Türler, A.

    2014-01-01

    With the aim to interpret results of gas-phase chromatography experiments on volatility of group-4 tetrachlorides and oxychlorides including those of Rf, adsorption enthalpies of these species on neutral, and modified quartz surfaces were estimated on the basis of relativistic, two-component Density Functional Theory calculations of MCl 4 , MOCl 2 , MCl 6 − , and MOCl 4 2 with the use of adsorption models. Several mechanisms of adsorption were considered. In the case of physisorption of MCl 4 , the trend in the adsorption energy in the group should be Zr > Hf > Rf, so that the volatility should change in the opposite direction. The latter trend complies with the one in the sublimation enthalpies, ΔH sub , of the Zr and Hf tetrachlorides, i.e., Zr < Hf. On the basis of a correlation between these quantities, ΔH sub (RfCl 4 ) was predicted as 104.2 kJ/mol. The energy of physisorption of MOCl 2 on quartz should increase in the group, Zr < Hf < Rf, as defined by increasing dipole moments of these molecules along the series. In the case of adsorption of MCl 4 on quartz by chemical forces, formation of the MOCl 2 or MOCl 4 2− complexes on the surface can take place, so that the sequence in the adsorption energy should be Zr > Hf > Rf, as defined by the complex formation energies. In the case of adsorption of MCl 4 on a chlorinated quartz surface, formation of the MCl 6 2− surface complexes can occur, so that the trend in the adsorption strength should be Zr ≤ Hf < Rf. All the predicted sequences, showing a smooth change of the adsorption energy in the group, are in disagreement with the reversed trend Zr ≈ Rf < Hf, observed in the “one-atom-at-a-time” gas-phase chromatography experiments. Thus, currently no theoretical explanation can be found for the experimental observations

  17. Foveal slope measurements in diabetic retinopathy: Can it predict development of sight-threatening retinopathy? Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS II, Report no 8

    Directory of Open Access Journals (Sweden)

    Laxmi Gella

    2015-01-01

    Full Text Available Aim: The aim was to assess the foveal slope configuration in subjects with type 2 diabetes in a population-based study. Materials and Methods: A subset of 668 subjects from Sankara Nethralaya Diabetic Retinopathy (DR Epidemiology and Molecular Genetics Study II, a population-based study, were included in the current study. All the subjects underwent comprehensive ophthalmic evaluation including spectral domain optical coherence tomography. Foveal thickness was assessed in five central early treatment DR study quadrants from the three-dimensional scan and foveal slope was calculated in all the four quadrants. Results: Subjects with sight-threatening DR (STDR had significantly shallow foveal slope in inferior quadrant (STDR: 7.33 ± 6.26 vs. controls: 10.31 ± 3.44; P = 0.021 when compared to controls and in superior (STDR: 7.62 ± 5.81 vs. no DR: 9.11 ± 2.82; P = 0.033, inferior (STDR: 7.33 ± 6.26 vs. no DR: 8.81 ± 2.81; P = 0.048, and temporal quadrants (STDR: 6.69 ± 5.70 vs. no DR: 7.97 ± 2.33; P = 0.030 when compared to subjects with no DR. Foveal slope was significantly shallow among the older age groups in subjects with no DR (P < 0.001 and non-STDR (P = 0.027. Average foveal slope in the diabetic subjects was independently and significantly correlated with increase in age (r = −0.241; P < 0.001 and central subfield thickness (r = −0.542; P < 0.001. Conclusion: Changes in foveal slope were seen with increasing age; however, in diabetes these segmental slope changes can be seen in late DR (STDR.

  18. RECURSOS MULTIMEDIA PARA EL APRENDIZAJE DE CONTABILIDAD FINANCIERA EN LOS GRADOS BILINGÜES

    Directory of Open Access Journals (Sweden)

    María del Mar Camacho Miñano

    2016-01-01

    Full Text Available En el entorno educativo actual se hacen necesarias estrategias que mejoren la calidad de la docencia con la finalidad de aumentar el aprendizaje signifi - cativo del alumno. De hecho, una de las preocupaciones que tiene la univer - sidad para adaptarse al Espacio Europeo de Educación Superior (EEES es el distanciamiento entre la vida real y la teoría académica. En este artículo se presentan los resultados obtenidos, tras el diseño a través de un proyecto de innovación docente, sobre la utilización en las aulas de recursos multimedia (videos, tests, ejercicios prácticos relacionados, casos particulares, trabajos en equipo colaborativo, blog, lecturas... realizados «ad hoc» por profesores del Departamento de Economía Financiera y Contabilidad II de la Universidad Complutense de Madrid. Como parte del estudio se ha realizado una encuesta a los alumnos de segundo curso de las asignaturas de «Financial Accoun - ting II» del Grado de Administración y Dirección de Empresas (GADE y de «Analytical Accounting» del Grado de Economía (GECO donde expresaron su percepción y motivación al aprendizaje de la asignatura. Los resultados se han tratado estadísticamente obteniendo conclusiones muy interesantes. La mayoría de los alumnos han encontrado los videos útiles, satisfactorios y motivadores, aunque complejos. Por otro lado, se ha conseguido el objetivo de realizar un primer acercamiento al mundo profesional de la empresa a los alumnos desde su segundo año de carrera. Al tratarse de Grados bilingües, se han grabado a profesionales de importantes empresas españolas en inglés. Todo ello sirve de estímulo al estudiante que, en el futuro, puede conseguir al - canzar dichos puestos de responsabilidad. Además, el profesor dispone de un material que se ajusta perfectamente a la metodología docente activa y a sus necesidades, porque ha participado directamente en su diseño y realización.

  19. Les zones de rejet végétalisées Planted Discharge Area

    Directory of Open Access Journals (Sweden)

    BOUTIN, Catherine ; PROST-BOUCLE, Stéphanie

    2012-12-01

    Full Text Available Les zones de rejet végétalisées sont des espaces aménagés entre la station d’épuration et le milieu récepteur, censés contribuer à la réduction de l’impact des rejets sur le milieu naturel. Leur fort développement observé en France depuis une dizaine d’années souligne l’importance de lever les diverses incertitudes concernant la pertinence des objectifs visés et les limites réglementaires, afin d’encadrer concrètement la mise en œuvre de ces nouveaux ouvrages.Planted Discharge Areas (PDA are placed between the outlet of the WasteWater Treatment Plant (WWTP and the receiving body. They may receive treated wastewater, stromwater or the both. Today, the French Authorities don’t assign any efficiency requirements to a planted discharge areas. The expected objectives from such landscape laying-out are various: i reduction of the volumes discharged into the river, ii qualitative improvement of some parameters (nitrogen, phosphor, micro-polluting, faecal contamination, iii production of biomass, iv landscape integration and environmental benefits, … Mechanisms involved in a PDA are multiple and concern 3 compartments: free surface water, soil, vegetation. It’s necessary to analyse each of these compartments according to the local conditions and on-site measurements are necessary. The “soil” compartment is the most important and needs to be study (pedological, geological and hydrogeological properties before any construction of PDA.This article also presents the results of a national survey carried out in 2011. They confirm the explosion of the number of these systems over the last 5 years. This survey also underlines the diversity of the situations (WWTP capacity, area and hydraulic loads, design, expected objectives without allowing to establish a simple link between the various parameters. Today, it is not possible to assert that PDAs always have a beneficial effect regarding the protection of the surface

  20. ¿Cuál es el objetivo principal de la mercadotecnia?

    Directory of Open Access Journals (Sweden)

    Francisco Gerardo Barroso Tanoira

    2008-01-01

    Full Text Available Hay quienes piensan que el objetivo principal de la mercadotecnia es vender más, o bien, colocar productos y distribuirlos, o que es una herramienta para atraer a los clientes o inclusive para manipularlos. El objetivo del presente ensayo es reflexionar sobre el objetivo principal de esta disciplina, la cual es realmente una filosofía de vida empresarial. Se concluye que dicho objetivo es fomentar el intercambio voluntario entre dos o más partes que tienen algo que interesa a unos y a otros entre sí. El resultado de dicho intercambio, el cual es la clave en el proceso de la mercadotecnia, es lograr más ventas a través de satisfacer a los clientes y conseguir su lealtad mediante la identificación de sus necesidades y deseos, conjuntándolos con productos y servicios de calidad. Otra conclusión es que la satisfacción del cliente y las ventas, que para la empresa son objetivos, para la mercadotecnia son resultados del correcto fomento del intercambio voluntario en la gestión de negocios, el cual es su objetivo como disciplina en sí. Por otra parte, tampoco puede decirse que el mercadólogo sea un creador de necesidades ya que su papel es detectarlas y proponer los satisfactores para las mismas.

  1. ¿Es el cuadrado un rectángulo?

    Directory of Open Access Journals (Sweden)

    Orlando Aya Corredor

    2016-03-01

    Full Text Available El concepto de un objeto geométrico está mediado, entre otras cosas, por las experiencias que se tienen con él. La hipótesis de este estudio es que realizar un proceso de conceptualización de un objeto, con el uso de un entorno de geometría dinámica, ayuda no solo a formular, formalizar y estructurar definiciones jerárquicas y económicas de los objetos, sino además a hacer obstensible la definición con la que los estudiantes trabajan en un contexto de actividad demostrativa. Para sustentar la hipótesis se analizaron sesiones de clases de dos espacios académicos consecutivos de un programa de formación inicial de profesores, y un cuestionario aplicado a los estudiantes. Se buscaron así evidencias que permitieran, sustentado en el marco teórico que orientó el estudio, determinar el impacto de trabajar en un entorno donde se usa un software de geometría dinámica como mediador para el aprendizaje. Los resultados permitieron establecer, entre otras cosas, que el trabajo realizado con geometría dinámica debe ir acompañado de acciones intencionadas orientadas por la docente. Se evidenció que se continúan presentando, aún después de usar geometría dinámica, varias dificultades respecto al concepto del objeto geométrico cuadrado, como el predominio de los aspectos figurales sobre los conceptuales, y la dificultad para modificar las definiciones personales del concepto y las imágenes conceptuales, que surgen cuando los estudiantes realizan actividad demostrativa.

  2. ¿Qué es una emoción?

    Directory of Open Access Journals (Sweden)

    Mora Teruel, Francisco

    2013-02-01

    Full Text Available Gregorio Marañón wrote relatively little about emotion. Nevertheless, he considered emotion to be “one of the most interesting problems of human life.” This article describes the basic brain processes of emotion that motivates living beings to follow patterns of behaviour whose ultimate meaning is the survival of the individual and the species. A description is given here of the emotional processing of sensory information. It is noted that any process of conscious learning and memory is always emotionally coloured. Finally, one of the main conclusions of this article is that there is no rational thought without a previous emotional process in the brain. There is no reason without emotion. This is a conclusion that would probably have amazed Professor Marañón.El Dr. Gregorio Marañón no escribió mucho sobre la emoción. Pero sí es cierto que consideró que se trataba de “uno de los problemas más interesantes de la vida humana”. En este artículo se describen los procesos cerebrales básicos de la emoción que nos alertan y motivan hacia la realización de conductas en cuyo significado último se encuentra la supervivencia del individuo y de la especie. Se describe el procesamiento emocional de la información sensorial. Se señala que todo proceso de aprendizaje y memoria consciente siempre viene coloreado emocionalmente. Y se destaca que el profesor Marañón posiblemente mostraría asombro ante una de las principales conclusiones de este artículo en las que se indica que no hay pensamiento sin una emoción previa que lo alimente. Que no hay razón sin emoción.

  3. SRS ES and H Standards Compliance Program Implementation Plan

    International Nuclear Information System (INIS)

    Hearn, W.H.

    1993-01-01

    On March 8, 1990, the Defense Nuclear Facilities Safety Board (DNFSB) issued Recommendation 90-2 to the Secretary of Energy. This recommendation, based upon the DNFSB's initial review and evaluation of the content and implementation of standards relating to the design, construction, operations, and decommissioning of defense nuclear facilities of the U.S. Department of Energy (DOE), called for three actions: identification of specific standards that apply to design, construction, operation and decommissioning of DOE facilities; assessment of the adequacy of those standards for protecting public health and safety; and determination of the extent to which they have and are being implemented. The purpose of this Implementation Plan is to define the single program for all sitewide and facility 90-2 ES and H Standards Compliance efforts, which will satisfy the HQ Implementation Plan, avoid duplicate efforts, be as simple and achievable as possible, include cost-saving innovations, use a graded approach based on facility hazards and future needs of facilities, and support configuration control for facility requirements. The Defense Waste Processing Facility (DWPF) has been designated a pilot facility for the 90-2 program and has progressed with their facility program ahead of the site-level program. The DWPF, and other Government-Owned Contractor-Operated (GOCO) facilities that progress on an enhanced schedule, will serve as pilot facilities for the site-level program. The lessons learned with their requirement identifications, and their assessments of the adequacy of and their compliance with these requirements will be used to improve the efficiency of the site-level and subsequent programs

  4. Que es lo que queda cuando el agua se va

    Directory of Open Access Journals (Sweden)

    Hernán Ascui Fernández

    2007-10-01

    Full Text Available El agua siempre deja huellas de su paso. Las aguas del Nilo, después de inundar las llanuras del río, se retiraban dejando el suelo colmado de los nutrientes que habían traído desde el corazón de África. Las costas de Chile han sido modeladas por el ir y venir de las aguas marinas, el río Ibáñez ha esculpido un profundo canal en la roca para abrirse paso, dando nacimiento a un magnífico lugar conocido como Garganta del río Ibáñez. Las cascadas horadan montañas para poder deslizarse como blancas lágrimas, la sobrecogedora belleza de los glaciares ha dejado potentes huellas de sus trayectorias. La lluvia también deposita marcas en los lugares y superficies que moja. A veces son apenas sutiles señales como el musgo que crece en las piedras húmedas o en el perfume de los bosques de Valdivia, con su tierra negra y empapada de lluvia y rocío. Otras veces las huellas del agua están presentes en la arquitectura como ocurre con los palafitos de Castro o Caleta Tortel, donde las casas se levantan para tomar distancia del agua que se mueve al ritmo de las mareas. En otras ocasiones, las huellas del descorren el velo de un drama urbano; es lo que ocurrió con la inundación del invierno pasado. Las huellas del agua aún son visibles en las paredes manchadas, en los muebles, en los pisos. El agua se fue pero dejando tras de sí un desalentador recuerdo de su paso por las ciudades, los pueblos y las casas.

  5. Concentra??o nas exporta??es de eletroeletr?nicos do Polo Industrial de Manaus: aspectos quantitativos e percep??es institucionais

    OpenAIRE

    Lopes, Vitor Cesar Pican?o

    2012-01-01

    Esta disserta??o tem como objetivo principal analisar a evolu??o da concentra??o das exporta??es do Subsetor de Eletroeletr?nicos do Polo Industrial de Manais - PIM, verificando as poss?veis implica??es de tal fen?meno em termos de afeta??o no ?mbito comercial do mesmo. Os dados da pesquisa compreendem dois n?veis: dados secund?rios de com?rcio exterior, provenientes dos sistemas de acompanhamento e controle do fluxo de exporta??es do Minist?rio da Ind?stria e Com?rcio MDIC e Superint...

  6. Predictive medicine

    NARCIS (Netherlands)

    Boenink, Marianne; ten Have, Henk

    2015-01-01

    In the last part of the twentieth century, predictive medicine has gained currency as an important ideal in biomedical research and health care. Research in the genetic and molecular basis of disease suggested that the insights gained might be used to develop tests that predict the future health

  7. Influence of Carbon Sources and Electron Shuttles on Ferric Iron Reduction by Cellulomonas sp. Strain ES6

    Energy Technology Data Exchange (ETDEWEB)

    Erin K. Field; Robin Gerlach; Sridhar Viamajala; Laura K. Jennings; Alfred B. Cunningham; Brent M. Peyton; William A. Apel

    2011-09-01

    The reduction of hexavalent chromium, Cr(VI), to trivalent chromium, Cr(III), can be an important aspect of remediation processes at Department of Energy (DOE) and other contaminated sites. Cellulomonas species are found at several Cr(VI) contaminated and uncontaminated locations at the DOE site in Hanford, Washington. Members of this genus have demonstrated the ability to effectively reduce Cr(VI) to Cr(III) fermentatively and therefore play a potential role in hexavalent chromium remediation at this site. Batch studies were conducted with Cellulomonas sp. strain ES6 to assess the influence of various carbon sources, iron minerals, and electron shuttling compounds on Cr(VI) reduction. These chemical species are likely to be present in these terrestrial environments during in situ bioremediation. Results indicated that there were a number of interactions between these compounds that influenced Cr(VI) reduction rates. The type of carbon source as well as the type of electron shuttle present influenced Cr(VI) reduction rates. When an electron shuttle, such as anthraquinone-2,6-disulfonate (AQDS), was present in the system, reduction rates increased significantly. Biologically reduced AQDS (AHDS) reduced Cr(VI) almost instantaneously. The presence of iron minerals and their concentrations did not significantly influence Cr(VI) reduction rates. However, strain ES6 or AQDS could directly reduce surface-associated Fe(III) to Fe(II) which was capable of reducing Cr(VI) at a near instantaneous rate. These results suggest the rate limiting step in these systems is the transfer of electrons from strain ES6 to the intermediate or terminal electron acceptor whether that is Cr(VI), Fe(III), or AQDS.

  8. Theoretical predictions of properties and volatility of chlorides and oxychlorides of group-4 elements. II. Adsorption of tetrachlorides and oxydichlorides of Zr, Hf, and Rf on neutral and modified surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Pershina, V., E-mail: V.Pershina@gsi.de [GSI Helmholtzzentrum für Schwerionenforschung, Planckstr. 1, Darmstadt D-64291 (Germany); Borschevsky, A. [Helmholtz Institute Mainz, Mainz D-55128, Germany and Centre for Theoretical Chemistry and Physics, New Zealand Institute for Advanced Study, Massey University, Private Bag 102904, 0745 North Shore MSC, Auckland (New Zealand); Iliaš, M. [Department of Chemistry, Faculty of Natural Sciences, Matej Bel University, Tajovského 40, SK-974 00 Banská Bystrica (Slovakia); Türler, A. [Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland and Laboratory for Radiochemistry and Environmental Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)

    2014-08-14

    With the aim to interpret results of gas-phase chromatography experiments on volatility of group-4 tetrachlorides and oxychlorides including those of Rf, adsorption enthalpies of these species on neutral, and modified quartz surfaces were estimated on the basis of relativistic, two-component Density Functional Theory calculations of MCl{sub 4}, MOCl{sub 2}, MCl{sub 6}{sup −}, and MOCl{sub 4}{sup 2} with the use of adsorption models. Several mechanisms of adsorption were considered. In the case of physisorption of MCl{sub 4}, the trend in the adsorption energy in the group should be Zr > Hf > Rf, so that the volatility should change in the opposite direction. The latter trend complies with the one in the sublimation enthalpies, ΔH{sub sub}, of the Zr and Hf tetrachlorides, i.e., Zr < Hf. On the basis of a correlation between these quantities, ΔH{sub sub}(RfCl{sub 4}) was predicted as 104.2 kJ/mol. The energy of physisorption of MOCl{sub 2} on quartz should increase in the group, Zr < Hf < Rf, as defined by increasing dipole moments of these molecules along the series. In the case of adsorption of MCl{sub 4} on quartz by chemical forces, formation of the MOCl{sub 2} or MOCl{sub 4}{sup 2−} complexes on the surface can take place, so that the sequence in the adsorption energy should be Zr > Hf > Rf, as defined by the complex formation energies. In the case of adsorption of MCl{sub 4} on a chlorinated quartz surface, formation of the MCl{sub 6}{sup 2−} surface complexes can occur, so that the trend in the adsorption strength should be Zr ≤ Hf < Rf. All the predicted sequences, showing a smooth change of the adsorption energy in the group, are in disagreement with the reversed trend Zr ≈ Rf < Hf, observed in the “one-atom-at-a-time” gas-phase chromatography experiments. Thus, currently no theoretical explanation can be found for the experimental observations.

  9. II Jornada de Cultura Jurídica

    Directory of Open Access Journals (Sweden)

    Manuel Vial Dumas

    2016-07-01

    Full Text Available

    El passat 18 de març de 2016 es va celebrar a la seu institucional de la UOC (avinguda del Tibidabo, núm. 39-43 de Barcelona la II Jornada de Cultura Jurídica, organitzada pels Estudis de Dret i Ciència Política de la UOC i la Càtedra de Cultura Jurídica de la Universitat de Girona (UdG.

  10. Theoretical predictions of properties and volatility of chlorides and oxychlorides of group-4 elements. II. Adsorption of tetrachlorides and oxydichlorides of Zr, Hf, and Rf on neutral and modified surfaces

    Science.gov (United States)

    Pershina, V.; Borschevsky, A.; Iliaš, M.; Türler, A.

    2014-08-01

    With the aim to interpret results of gas-phase chromatography experiments on volatility of group-4 tetrachlorides and oxychlorides including those of Rf, adsorption enthalpies of these species on neutral, and modified quartz surfaces were estimated on the basis of relativistic, two-component Density Functional Theory calculations of MCl4, MOCl2, MCl6-, and MOCl42 with the use of adsorption models. Several mechanisms of adsorption were considered. In the case of physisorption of MCl4, the trend in the adsorption energy in the group should be Zr > Hf > Rf, so that the volatility should change in the opposite direction. The latter trend complies with the one in the sublimation enthalpies, ΔHsub, of the Zr and Hf tetrachlorides, i.e., Zr Hf > Rf, as defined by the complex formation energies. In the case of adsorption of MCl4 on a chlorinated quartz surface, formation of the MCl62- surface complexes can occur, so that the trend in the adsorption strength should be Zr ≤ Hf < Rf. All the predicted sequences, showing a smooth change of the adsorption energy in the group, are in disagreement with the reversed trend Zr ≈ Rf < Hf, observed in the "one-atom-at-a-time" gas-phase chromatography experiments. Thus, currently no theoretical explanation can be found for the experimental observations.

  11. PADRÕES DE DISTRIBUIÇÕES ESPACIAIS E TEMPORAIS DE TEMPERATURAS ASSOCIADOS AO BIOMA CERRADO

    Directory of Open Access Journals (Sweden)

    Nicali Bleyer Ferreira dos Santos

    2011-01-01

    Full Text Available La presencia de vegetación es un factor importante en el mantenimiento de los procesos biogeoquímicos de la naturaleza. En el Cerrado, la conversión de la vegetación natural en las áreas de la agricultura y de pastoreo induce cambios en las variables biofísicas tales como la temperatura de superficie, altamente sensible a los cambios en la cubierta terrestre. Así, con el fin de contribuir a la comprensión de la dinámica de causa y efecto del uso y ocupación de la región del Cerrado en variables biofísicas, este estudio pretende analizar, a partir de informaciones procedentes del sensor orbital (producto MOD11 - Land Surface Temperature, la correlación entre la ocupación de la tierra y la variabilidad térmica de la superfície. El estúdio fue hecho para el año 2003 en los meses de mayo y septiembre (principio y fin de la sequía. Con este fin, su investigación ha vinculado las diversas formas de ocupación (expresadas por las categorías de uso del suelo con la temperatura de superficie. El análisis de los datos mostro diferencias térmicas significtivas entre las classes naturales e antropizadas y revelo las dependências espaciales de la temperatura de la superfície, com uma fuerte influencia de la estacionalidad.

  12. Asi Aprendemos. Que Bonito Es Leer, II. Libro 1. Cuaderno de Lectura (This Is How We Learn. How Nice Reading Is, II. Book 1. Reading Book).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is a Spanish reader designed to be used as a supplement to second-grade bilingual reading instruction. The reader is accompanied by a workbook and a teacher's manual. The book consists of seven stories, the first having to do with vowels, the following three with school, and the last three with the family. (AM)

  13. Noche del Sol. Que Bonito Es Leer, II. Libro III. Libro de Lectura (Night of the Sun. How Nice Reading Is, II. Book III. Reading Book).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    Third in a series of materials designed to supplement the teaching of reading in Spanish at the second grade level, this reader is accompanied by a workbook and a teacher's guide of the same title. There are seven stories in Spanish, from six to fourteen pages in length, and illustrated in black and white. The first four stories demonstrate the…

  14. Noche del Sol. Que Bonito Es Leer, II. Libro III. Cuaderno de Ejercicios (Night of the Sun. How Nice Reading Is, II. Book III. Workbook).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    The lessons, games and exercises in the workbook are follow-up work for the units in the reader of the same title. There are many vocabulary, punctuation, and grammar exercises, and spelling games and drills. Additionally, there is an incomplete story for the child to finish by using appropriate words to complete each sentence. These exercises are…

  15. Noche del Sol. Que Bonito Es Leer, II. Libro III. Guia Para el Maestro (Night of the Sun. How Nice Reading Is, II. Book III. Teacher's Guide).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    The Spanish language teacher's guide is part of the third level of a series of supplementary materials designed for teaching second grade reading in Spanish. The manual is a detailed guide to the use of the reader and workbook of the same title. It contains an explanatory introduction and an extensive list of objectives, for each of the five to…

  16. Asi Aprendemos. Que Bonito Es Leer, II. Libro I. Cuaderno de Ejercicios (This Is How We Learn. How Nice Reading Is, II. Book I. Workbook).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This workbook is intended to be used in connection with the reader of the same title, for bilingual Spanish-English reading instruction in the second grade. It is further supplemented by a teacher's manual. As a follow-up to the stories contained in the reader, the workbook provides drawing games, word games, punctuation exercises, and other…

  17. Hombres y Lugares. Que Bonito Es Leer, II. Libro IV. Libro de Lectura (Men and Places. How Nice Reading Is, II. Book IV. Reading Book).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    With the accompanying workbook and teacher's guide, this reader comprises the fourth and last level of a series of supplementary instructional materials for teaching reading in Spanish to second grade students. There are six stories, each from 8 to 14 pages in length, and one "corrido". All are written in Spanish. Black and white illustrations…

  18. Asi Aprendemos. Que Bonito Es Leer, II. Libro I. Guia Para el Maestro (This Is How We Learn. How Nice Reading Is, II. Book I. Teacher's Guide).

    Science.gov (United States)

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This teacher's manual is designed to accompany the reader and the workbook of the same title. An introduction to the series is followed by a discussion of course objectives and diagnostic testing of reading. The guide follows the structure of the companion reader, which consists of 7 stories dealing with vo