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  1. Equatorial Guinea.

    Science.gov (United States)

    1989-03-01

    Equatorial Guinea is situated on the Gulf of Guinea along the west African coast between Cameroon and Gabon. The people are predominantly of Bantu origin. The country's ties with Spain are significant; in 1959, it became the Spanish Equatorial region ruled by Spain's commissioner general. Recent political developments in Equatorial Guinea include the formation of the Democratic Party for Equatorial Guinea in July of 1987 and the formation of a 60-member unicameral Chamber of Representatives of the People in 1983. Concerning the population, 83% of the people are Catholic and the official language is Spanish. Poverty and serious health, education and sanitary problems exist. There is no adequate hospital and few trained physicians, no dentists, and no opticians. Malaria is endemic and immunization for yellow fever is required for entrance into the country. The water is not potable and many visitors to the country bring bottled water. The tropical climate of Equatorial Guinea provides the climate for the country's largest exports and source of economy; cacao, wood and coffee. Although the country, as a whole, has progressed towards developing a participatory political system, there are still problems of governmental corruption in the face of grave health and welfare conditions. In recent years, the country has received assistance from the World Bank and the United States to aid in its development.

  2. The oil boom in Equatorial Guinea

    International Nuclear Information System (INIS)

    Frynas, J.G.

    2004-01-01

    In less than a decade, Equatorial Guinea has transformed itself from an African backwater into one of the world's fastest growing economies and a sought-after political partner in the Gulf of Guinea. The sole reason for this transformation has been the discovery of oil and gas. This article outlines the rise of Equatorial Guinea as one of Africa's leading oil-producing countries and investigates the political, economic and social effects of becoming a petro-state. The article is based on the author's field research in Equatorial Guinea in the autumn of 2003 and interviews with senior oil company staff, government officials and staff of international organizations as well as secondary sources. This research demonstrates how reliance on oil and gas exports can lead to profound changes in a country's political economy. (author)

  3. Nutritional and socio-economic factors associated with Plasmodium falciparum infection in children from Equatorial Guinea: results from a nationally representative survey

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    Bernis Cristina

    2009-10-01

    Full Text Available Abstract Background Malaria has traditionally been a major endemic disease in Equatorial Guinea. Although parasitaemia prevalence on the insular region has been substantially reduced by vector control in the past few years, the prevalence in the mainland remains over 50% in children younger than five years. The aim of this study is to investigate the risk factors for parasitaemia and treatment seeking behaviour for febrile illness at country level, in order to provide evidence that will reinforce the EG National Malaria Control Programme. Methods The study was a cross-sectional survey of children 0 to 5 years old, using a multistaged, stratified, cluster-selected sample at the national level. It included a socio-demographic, health and dietary questionnaires, anthropometric measurements, and thick and thin blood smears to determine the Plasmodium infection. A multivariate logistic regression model was used to determine risk factors for parasitaemia, taking into account the cluster design. Results The overall prevalence of parasitemia was 50.9%; it was higher in rural (58.8% compared to urban areas (44.0%, p = 0.06. Age was positively associated with parasitemia (p Conclusion Results suggest that a national programme to fight malaria in Equatorial Guinea should take into account the differences between rural and urban communities in relation to risk factors for parasitaemia and treatment seeking behaviour, integrate nutrition programmes, incorporate campaigns on the importance of early treatment, and target appropriately for bed nets to reach the under-fives.

  4. Radiation protection in hospitals of Equatorial Guinea

    International Nuclear Information System (INIS)

    Rabat Macambo, P.

    2001-01-01

    With a population of four hundred thousand (400.000) inhabitants and distributed in a territory of 28 thousand (28.000) km 2 , the use of ionizing radiations for medical practice in Equatorial Guinea is few and decreasing. It is used for diagnostic practices in the main hospitals of the country, where the work burden is not over 20 patients per day. The political, social and economical embryonic development of the country until recently had a negative influence on indicators and health organisations, so that even now the country does not have any radiological protection law, this shortness, in addition with the old architectural structure that x ray tools is lodging, as well as dosimetrical lack of employed staff, put this staff under risk of electromagnetic energy. This is to show the present survey of medical activities with ionizing radiation and to request technical support for implementing suitably the basic standards of radiation protection which will help us as basis for the elaboration outline law, on radiological protection in accordance with the new guidelines of the International Atomic Energy Agency. (author)

  5. Molecular characterization of Cryptosporidium isolates from humans in Equatorial Guinea.

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    Blanco, María Alejandra; Iborra, Asunción; Vargas, Antonio; Nsie, Eugenia; Mbá, Luciano; Fuentes, Isabel

    2009-12-01

    The aim of the study was to perform a molecular characterization of clinical isolates of Cryptosporidium species from Equatorial Guinea. Standard laboratory methods were used to identify 35 cryptosporidiosis cases among 185 patients. PCR-RFLP successfully identified 34 Cryptosporidium species from these 35 cases, comprising C. parvum (52.9%), C. hominis (44.1%) and C. meleagridis (2.9%); over 90% of the species were isolated from HIV-positive patients. This is the first report of the molecular characterization of Cryptosporidium species isolated from humans in Equatorial Guinea and shows that zoonotic and anthroponotic transmission is present in this country.

  6. Priority areas for large mammal conservation in Equatorial Guinea.

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    Murai, Mizuki; Ruffler, Heidi; Berlemont, Antoine; Campbell, Genevieve; Esono, Fidel; Agbor, Anthony; Mbomio, Domingo; Ebana, Agustín; Nze, Antonio; Kühl, Hjalmar S

    2013-01-01

    Hunting is one of the main driving forces behind large mammal density distribution in many regions of the world. In tropical Africa, urban demand for bushmeat has been shown to dominate over subsistence hunting and its impact often overrides spatial-ecological species characteristics. To effectively protect remaining mammal populations the main factors that influence their distribution need to be integrated into conservation area prioritisation and management plans. This information has been lacking for Río Muni, Equatorial Guinea, as prior studies have been outdated or have not systematically covered the continental region of the country. In this study we evaluated: 1) the relative importance of local vs. commercial hunting; 2) wildlife density of protected vs. non-protected areas; and 3) the importance of ecological factors vs. human influence in driving mammal density distribution in Río Muni. We adopted a systematic countrywide line transect approach with particular focus on apes and elephants, but also including other mammal species. For analysis of field data we used generalised linear models with a set of predictor variables representing ecological conditions, anthropogenic pressure and protected areas. We estimate that there are currently 884 (437-1,789) elephants and 11,097 (8,719-13,592) chimpanzees and gorillas remaining in Río Muni. The results indicate strong hunting pressures on both local and commercial levels, with roads demonstrating a negative impact on elephants and overall mammal body mass. Protected areas played no role in determining any of the mammal species distributions and significant human hunting signs were found inside these protected areas, illustrating the lack of environmental law enforcement throughout the country. Río Muni is currently under-represented in conservation efforts in Western Equatorial Africa, and we recommend a focus on cross-boundary conservation, in particular in the Monte Alén-Monts de Cristal and Río Campo

  7. Priority areas for large mammal conservation in Equatorial Guinea.

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    Mizuki Murai

    Full Text Available Hunting is one of the main driving forces behind large mammal density distribution in many regions of the world. In tropical Africa, urban demand for bushmeat has been shown to dominate over subsistence hunting and its impact often overrides spatial-ecological species characteristics. To effectively protect remaining mammal populations the main factors that influence their distribution need to be integrated into conservation area prioritisation and management plans. This information has been lacking for Río Muni, Equatorial Guinea, as prior studies have been outdated or have not systematically covered the continental region of the country. In this study we evaluated: 1 the relative importance of local vs. commercial hunting; 2 wildlife density of protected vs. non-protected areas; and 3 the importance of ecological factors vs. human influence in driving mammal density distribution in Río Muni. We adopted a systematic countrywide line transect approach with particular focus on apes and elephants, but also including other mammal species. For analysis of field data we used generalised linear models with a set of predictor variables representing ecological conditions, anthropogenic pressure and protected areas. We estimate that there are currently 884 (437-1,789 elephants and 11,097 (8,719-13,592 chimpanzees and gorillas remaining in Río Muni. The results indicate strong hunting pressures on both local and commercial levels, with roads demonstrating a negative impact on elephants and overall mammal body mass. Protected areas played no role in determining any of the mammal species distributions and significant human hunting signs were found inside these protected areas, illustrating the lack of environmental law enforcement throughout the country. Río Muni is currently under-represented in conservation efforts in Western Equatorial Africa, and we recommend a focus on cross-boundary conservation, in particular in the Monte Alén-Monts de Cristal

  8. Self-reported adherence to antiretroviral therapy in HIV+ population from Bata, Equatorial Guinea.

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    Salmanton-García, Jon; Herrador, Zaida; Ruiz-Seco, Pilar; Nzang-Esono, Jesús; Bendomo, Veronica; Bashmakovic, Emma; Nseng-Nchama, Gloria; Benito, Agustín; Aparicio, Pilar

    2016-01-01

    The human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS) represent a serious public health problem in Equatorial Guinea, with a prevalence of 6.2% among adults. the high-activity antiretroviral treatment (HAART) coverage data is 10 points below the overall estimate for Sub-Saharan Africa, and only 61% patients continue with HAART 12 months after it started. This study aims to assess HAART adherence and related factors in Litoral Province of Equatorial Guinea. In this cross-sectional study, socio-demographic and clinical data were collected at Regional Hospital of Bata, during June-July 2014. Adherence to treatment was assessed by using the Spanish version of CEAT-VIH. Bivariate and linear regression analyses were employed to assess HAART adherence-related factors. We interviewed 50 men (35.5%) and 91 women (64.5%), with a mean age of 47.7 ± 8.9 and 36.2 ± 11.2, respectively (p VIH score varied by ethnic group (p = .005). There was a positive correlation between CEAT-VIH score and current CD4 T-cells count (p = .013). The Cronbach's α value was 0.52. To our knowledge, this is the first study to assess HAART adherence in Equatorial Guinea. Internal reliability for CEAT-VIH was low, nonetheless the positive correlation between the CEAT-VIH score and the immunological status of patients add value to our findings. Our results serve as baseline for future research and will also assist stakeholders in planning and undertaking contextual and evidence-based policy initiatives.

  9. Genotype distribution of cervical human papillomavirus DNA in women with cervical lesions in Bioko, Equatorial Guinea

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    Carro-Campos Patricia

    2009-09-01

    Full Text Available Abstract Background The HVP vaccine is a useful tool for preventing cervical cancer. The purpose of this study is to determine the most frequent HPV genotypes in Equatorial Guinea in order to develop future vaccination strategies to apply in this country. Methods A campaign against cervical cancer was carried out in the area on a total of 1,680 women. 26 of the women, following cytological screening, were treated surgically with a loop electrosurgical excision procedure (LEEP. Cases were studied histologically and were genotyped from paraffin blocks by applying a commercial kit that recognized 35 HPV types. Results Cytological diagnoses included 17 HSIL, 1 LSIL, 5 ASC-H and 3 AGUS. Histological diagnosis resulted in 3 cases of microinvasive squamous cell carcinoma stage IA of FIGO, 9 CIN-3, 8 CIN-2, 2 CIN-1, 3 flat condylomas and mild dysplasia of the endocervical epithelium. Fifteen of twenty-five cases genotyped were positive for HPV (60%. HPV 16 and 33 were identified in four cases each, HPV 58 in two other cases, and HPV 18, 31, 52, and 82 in one case, with one HPV 16 and 58 coinfection. Conclusion The frequency of HPV types in the African area varies in comparison to other regions, particularly in Europe and USA. Vaccination against the five most common HPV types (16, 33, 58, 18, and 31 should be considered in the geographic region of West Africa and specifically in Equatorial Guinea.

  10. Genotype distribution of cervical human papillomavirus DNA in women with cervical lesions in Bioko, Equatorial Guinea.

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    García-Espinosa, Benjamín; Nieto-Bona, Ma Paz; Rueda, Sonsoles; Silva-Sánchez, Luís Fernando; Piernas-Morales, Ma Concepción; Carro-Campos, Patricia; Cortés-Lambea, Luís; Moro-Rodríguez, Ernesto

    2009-09-09

    The HVP vaccine is a useful tool for preventing cervical cancer. The purpose of this study is to determine the most frequent HPV genotypes in Equatorial Guinea in order to develop future vaccination strategies to apply in this country. A campaign against cervical cancer was carried out in the area on a total of 1,680 women. 26 of the women, following cytological screening, were treated surgically with a loop electrosurgical excision procedure (LEEP). Cases were studied histologically and were genotyped from paraffin blocks by applying a commercial kit that recognized 35 HPV types. Cytological diagnoses included 17 HSIL, 1 LSIL, 5 ASC-H and 3 AGUS. Histological diagnosis resulted in 3 cases of microinvasive squamous cell carcinoma stage IA of FIGO, 9 CIN-3, 8 CIN-2, 2 CIN-1, 3 flat condylomas and mild dysplasia of the endocervical epithelium. Fifteen of twenty-five cases genotyped were positive for HPV (60%). HPV 16 and 33 were identified in four cases each, HPV 58 in two other cases, and HPV 18, 31, 52, and 82 in one case, with one HPV 16 and 58 coinfection. The frequency of HPV types in the African area varies in comparison to other regions, particularly in Europe and USA. Vaccination against the five most common HPV types (16, 33, 58, 18, and 31) should be considered in the geographic region of West Africa and specifically in Equatorial Guinea.

  11. Serological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, equatorial Guinea.

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    Jackie Cook

    Full Text Available In order to control and eliminate malaria, areas of on-going transmission need to be identified and targeted for malaria control interventions. Immediately following intense interventions, malaria transmission can become more heterogeneous if interventions are more successful in some areas than others. Bioko Island, Equatorial Guinea, has been subject to comprehensive malaria control interventions since 2004. This has resulted in substantial reductions in the parasite burden, although this drop has not been uniform across the island.In 2008, filter paper blood samples were collected from 7387 people in a cross-sectional study incorporating 18 sentinel sites across Bioko, Equatorial Guinea. Antibodies were measured to P. falciparum Apical Membrane Antigen-1 (AMA-1 by Enzyme Linked Immunosorbent Assay (ELISA. Age-specific seropositivity rates were used to estimate seroconversion rates (SCR. Analysis indicated there had been at least a 60% decline in SCR in four out of five regions on the island. Changes in SCR showed a high degree of congruence with changes in parasite rate (PR and with regional reductions in all cause child mortality. The mean age adjusted concentration of anti-AMA-1 antibodies was mapped to identify areas where individual antibody responses were higher than expected. This approach confirmed the North West of the island as a major focus of continuing infection and an area where control interventions need to be concentrated or re-evaluated.Both SCR and PR revealed heterogeneity in malaria transmission and demonstrated the variable effectiveness of malaria control measures. This work confirms the utility of serological analysis as an adjunct measure for monitoring transmission. Age-specific seroprevalence based evidence of changes in transmission over time will be of particular value when no baseline data are available. Importantly, SCR data provide additional evidence to link malaria control activities to contemporaneous

  12. Genotype distribution of cervical human papillomavirus DNA in women with cervical lesions in Bioko, Equatorial Guinea

    OpenAIRE

    Garc?a-Espinosa, Benjam?n; Nieto-Bona, Ma Paz; Rueda, Sonsoles; Silva-S?nchez, Lu?s Fernando; Piernas-Morales, Ma Concepci?n; Carro-Campos, Patricia; Cort?s-Lambea, Lu?s; Moro-Rodr?guez, Ernesto

    2009-01-01

    Abstract Background The HVP vaccine is a useful tool for preventing cervical cancer. The purpose of this study is to determine the most frequent HPV genotypes in Equatorial Guinea in order to develop future vaccination strategies to apply in this country. Methods A campaign against cervical cancer was carried out in the area on a total of 1,680 women. 26 of the women, following cytological screening, were treated surgically with a loop electrosurgical excision procedure (LEEP). Cases were stu...

  13. Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades.

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    Cordon-Obras, Carlos; Cano, Jorge; Knapp, Jenny; Nebreda, Paloma; Ndong-Mabale, Nicolas; Ncogo-Ada, Policarpo Ricardo; Ndongo-Asumu, Pedro; Navarro, Miguel; Pinto, Joao; Benito, Agustin; Bart, Jean-Mathieu

    2014-01-17

    Luba is one of the four historical foci of Human African Trypanosomiasis (HAT) on Bioko Island, in Equatorial Guinea. Although no human cases have been detected since 1995, T. b. gambiense was recently observed in the vector Glossina palpalis palpalis. The existence of cryptic species within this vector taxon has been previously suggested, although no data are available regarding the evolutionary history of tsetse flies populations in Bioko. A phylogenetic analysis of 60 G. p. palpalis from Luba was performed sequencing three mitochondrial (COI, ND2 and 16S) and one nuclear (rDNA-ITS1) DNA markers. Phylogeny reconstruction was performed by Distance Based, Maximum Likelihood and Bayesian Inference methods. The COI and ND2 mitochondrial genes were concatenated and revealed 10 closely related haplotypes with a dominant one found in 61.1% of the flies. The sequence homology of the other 9 haplotypes compared to the former ranged from 99.6 to 99.9%. Phylogenetic analysis clearly clustered all island samples with flies coming from the Western African Clade (WAC), and separated from the flies belonging to the Central Africa Clade (CAC), including samples from Mbini and Kogo, two foci of mainland Equatorial Guinea. Consistent with mitochondrial data, analysis of the microsatellite motif present in the ITS1 sequence exhibited two closely related genotypes, clearly divergent from the genotypes previously identified in Mbini and Kogo. We report herein that tsetse flies populations circulating in Equatorial Guinea are composed of two allopatric subspecies, one insular and the other continental. The presence of these two G. p. palpalis cryptic taxa in Equatorial Guinea should be taken into account to accurately manage vector control strategy, in a country where trypanosomiasis transmission is controlled but not definitively eliminated yet.

  14. Healthcare in Equatorial Guinea, West Africa: obstacles and barriers to care.

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    Reuter, Kim Eleanor; Geysimonyan, Aurora; Molina, Gabriela; Reuter, Peter Robert

    2014-01-01

    The provision of healthcare services in developing countries has received increasing attention, but inequalities persist. One nation with potential inequalities in healthcare services is Equatorial Guinea (Central-West Africa). Mitigating these inequalities is difficult, as the Equatoguinean healthcare system remains relatively understudied. In this study, we interviewed members of the healthcare community in order to: 1) learn which diseases are most common and the most common cause of death from the perspective of healthcare workers; and 2) gain an understanding of the healthcare community in Equatorial Guinea by describing how: a) healthcare workers gain their professional knowledge; b) summarizing ongoing healthcare programs aimed at the general public; c) discussing conflicts within the healthcare community and between the public and healthcare providers; d) and addressing opportunities to improve healthcare delivery. We found that some causes of death, such as serious injuries, may not be currently treatable in country, potentially due to a lack of resources and trauma care facilities. In addition, training and informational programs for both healthcare workers and the general public may not be effectively transmitting information to the intended recipients. This presents hurdles to the healthcare community, both in terms of having professional competence in healthcare delivery and in having a community that is receptive to medical care. Our data also highlight government-facility communication as an opportunity for improvement. Our research is an important first step in understanding the context of healthcare delivery in Equatorial Guinea, a country that is relatively data poor.

  15. Conservation strategies for understanding and combating the primate bushmeat trade on Bioko Island, Equatorial Guinea.

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    Cronin, Drew T; Sesink Clee, Paul R; Mitchell, Matthew W; Bocuma Meñe, Demetrio; Fernández, David; Riaco, Cirilo; Fero Meñe, Maximiliano; Esara Echube, Jose Manuel; Hearn, Gail W; Gonder, Mary Katherine

    2017-11-01

    Bioko Island, Equatorial Guinea is among the important places in Africa for the conservation of primates, but a cultural preference for bushmeat and a lack of effective law enforcement has encouraged commercial bushmeat hunting, threatening the survival of the remaining primate population. For over 13 years, we collected bushmeat market data in the Malabo market, recording over 35,000 primate carcasses, documenting "mardi gras" consumption patterns, seasonal carcass availability, and negative effects resulting from government intervention. We also conducted forest surveys throughout Bioko's two protected areas in order to localize and quantify primate populations and hunting pressure. Using these data, we were able to document the significant negative impact bushmeat hunting had on monkey populations, estimate which species are most vulnerable to hunting, and develop ecological niche models to approximate the distribution of each of Bioko's diurnal primate species. These results also have allowed for the identification of primate hotspots, such as the critically important southwest region of the Gran Caldera Scientific Reserve, and thus, priority areas for conservation on Bioko, leading to more comprehensive conservation recommendations. Current and future efforts now focus on bridging the gap between investigators and legislators in order to develop and effectively implement a management plan for Bioko's Gran Caldera Scientific Reserve and to develop a targeted educational campaign to reduce demand by changing consumer attitudes toward bushmeat. Using this multidisciplinary approach, informed by biological, socioeconomic, and cultural research, there may yet be a positive future for the primates of Bioko. © 2017 Wiley Periodicals, Inc.

  16. Corporate philanthropy and conflicts of interest in public health: ExxonMobil, Equatorial Guinea, and malaria.

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    Shah, Naman K

    2013-01-01

    Equatorial Guinea, the most prosperous country in Africa, still bears a large malaria burden. With massive wealth from oil reserves, and nearly half its population living in island ecotypes favourable for malaria control, only poor governance can explain continued parasite burden. By financially backing the country's dictator and other officials through illicit payments, the oil company ExxonMobil contributed to the state's failure. Now ExxonMobil, having helped perpetuate malaria in Equatorial Guinea, gives money to non-governmental organizations, charitable foundations, and universities to advocate for and undertake malaria work. How, and on what terms, can public health engage with such an actor? We discuss challenges in the identification and management of conflicts of interest in public health activities. We reviewed the business and foundation activities of ExxonMobil and surveyed organizations that received ExxonMobil money about their conflict of interest policies. Reforms in ExxonMobil's business practices, as well as its charitable structure, and reforms in the way public health groups screen and manage conflicts of interest are needed to ensure that any relationship ultimately improves the health of citizens.

  17. From the African Coast, the invention of two territories: Equatorial Guinea and Ivory Coast

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    Adjoa Nathalie Chiyé Kessé

    2014-08-01

    Full Text Available From the African coast starts Latin American history and part of Europe’s. This article includes a comprehensive analysis on the cultural influence of Africa especially Equatorial Guinea and Côte d’Ivoire in Latin America. From the first European incursions into African coast (xvi century and throughout the colonial era, the paper highlights interethnic relations that occurred following the meeting and coexistence between cultures of both continents, an analysis that is essential to study the survival of traditions, beliefs and African customs that survive today in many regions of Latin America. Considering the importance now given to the recovery of identity traits of the past for studies of multi-ethnicity and re-construction of identities, this article can be used by researchers at Afro-descendance, notable in Latin America, whose research is related to African identity traits in their respective nations. Equatorial Guinea was a Spanish colony along with the Protectorate of Morocco and Western Sahara. The duration of this colony ran from 1885 to 1968. In 1926, it became the Spanish Guinea, and in 1968 it acquired its independance from Spain while retaining the Spanish cultural architecture. Furthermore, the French presence in this first stage of the conquest in Côte d’Ivoire, is provided by the army. The colonial authorities in Paris were not yet sufficiently organized to move their representatives to what was then known as the Poor or Bad People Coast or Coast of teeth. It was the military from Senegal, as base of the French colonial army who assumed the conquest and organization of the Ivorian territory for immediate exploitation of economic resources. It is this improvised framework without legal planning, which led to the idea of the invention of Africa supported by Valentin Mudimbe (1988 and Achille Mbembe (2000.

  18. Drivers of change in hunter offtake and hunting strategies in Sendje, Equatorial Guinea.

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    Gill, David J C; Fa, John E; Rowcliffe, J Marcus; Kümpel, Noëlle F

    2012-12-01

    Economic development in Africa is expected to increase levels of bushmeat hunting through rising demand for meat and improved transport infrastructure. However, few studies have tracked long-term changes in hunter behavior as a means of testing this prediction. We evaluated changes in hunter behavior in a rural community in Equatorial Guinea over a period of rapid national economic growth, during which time road access to the regional capital greatly improved. We conducted offtake surveys (Supporting Information) over 3 7-week periods at the same time of year in 1998, 2003, and 2010 and conducted hunter and household interviews (Supporting Information) in 2003 and 2010. We tested whether relations existed among catch, hunting effort, hunting strategy, and income earned through hunting and other livelihoods in 2003 and 2010. Although village offtake increased from 1775 kg in 1998 to 4172 kg in 2003, it decreased in 2010 to 1361 kg. Aggregate catch per unit effort (i.e., number of carcasses caught per hunter and per trap) decreased from 2003 to 2010, and the majority of hunters reported a decrease in abundance of local fauna. Although these results are indicative of unsustainable hunting, cumulative changes in offtake and catch per unit effort were driven by a contraction in the total area hunted following an out-migration of 29 of the village's hunters, most of whom left to gain employment in the construction industry, after 2003. Hunters operating in both 2003 and 2010 hunted closer to the village because an increased abundance of elephants posed a danger and because they desired to earn income through other activities. Our study provides an example of national economic development contributing to a reduction in the intensity and extent of hunting. ©2012 Society for Conservation Biology.

  19. Caregivers' Malaria Knowledge, Beliefs and Attitudes, and Related Factors in the Bata District, Equatorial Guinea.

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    Romay-Barja, Maria; Ncogo, Policarpo; Nseng, Gloria; Santana-Morales, Maria A; Herrador, Zaida; Berzosa, Pedro; Valladares, Basilio; Riloha, Matilde; Benito, Agustin

    2016-01-01

    Adequate community knowledge about malaria is crucial in order to improve prevention by reducing exposure to the disease. Malaria is a major cause of morbidity and mortality among children of less than five years of age in Equatorial Guinea. However, information concerning the accuracy of community knowledge is insufficient. This study aimed at assessing the depth of caregivers' knowledge of malaria, their beliefs and attitudes about this disease, and their socioeconomic determinants in the Bata district of Equatorial Guinea. A cross-sectional study was conducted in the district of Bata, involving 440 houses selected from 18 rural villages and 26 urban neighbourhoods. A combined "Malaria Knowledge Score" was generated based on caregivers' knowledge about transmission, symptoms, prevention, the treatment of children, and best place to seek treatment. Multivariate logistic regressions analyses were performed to assess those factors that are associated with knowledge about malaria. A total of 428 caregivers were interviewed; 255 (59.6%) and 173 (40.4%) lived in urban and rural areas respectively. Significant differences between rural and urban households were observed in caregivers' malaria knowledges and beliefs. Almost 42% of urban and 65% of rural caregivers were unaware as to how malaria is transmitted (OR = 2.69; 95% CI: 1.78-4.05). Together with rurality, the factors most significantly associated with the Malaria Knowledge were the level of education of the caregiver and the socioeconomic status of the household. Improvements in educational programs are needed to empower the most vulnerable households such that they can pro-actively implement malaria control measures. This could be achieved by a comprehensive communication strategy aimed at changing individual and community behaviours, and delivered by suitably trained community health workers and indoor residual spraying personnel.

  20. Impact of different strategies to control Plasmodium infection and anaemia on the island of Bioko (Equatorial Guinea

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    Roche Jesús

    2006-02-01

    Full Text Available Abstract Background On the island of Bioko (Equatorial Guinea, insecticide-treated nets (ITNs have been the main tool used to control malaria over the last 13 years. In 2004, started an indoor residual spraying (IRS campaign to control malaria. The purpose of this study is to asses the impact of the two control strategies on the island of Bioko (Equatorial Guinea, with regards to Plasmodium infection and anaemia in the children under five years of age. Methods Two transversal studies, the first one prior to the start of the IRS campaign and the second one year later. Sampling was carried out by stratified clusters. Malaria infection was measured by means of thick and thin film, and the packed cell volume (PCV percentage. Data related to ITN use and information regarding IRS were collected. The Pearson's chi-square and logistic regression statistical tests were used to calculate odds ratios (OR Results In the first survey, 168 children were sampled and 433 children in the second one. The prevalence of infection was 40% in 2004, and significantly lower at 21.7% in 2005. PCV was 41% and 39%, respectively. 58% of the children surveyed in 2004 and 44.3% in 2005 had slept under an ITN. 78% of the dwellings studied in 2005 had been sprayed. In the 2005 survey, sleeping without a mosquito net meant a risk of infection 3 times greater than sleeping protected with a net hanged correctly and with no holes (p Conclusion IRS and ITNs have proven to be effective control strategies on the island of Bioko. The choice of one or other strategy is, above all, a question of operational feasibility and availability of local resources.

  1. Parasitismo intestinal en una escuela primaria de Bata, Guinea Ecuatorial Intestinal parasitism in an elementary school in Bata, Equatorial Guinea

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    William Quintero Pérez

    2008-06-01

    Full Text Available Con el objetivo de precisar el grado de parasitismo intestinal según la edad, así como identificar los parásitos intestinales más frecuentes en la escuela primaria "Amiguitos de Jesús" de la ciudad de Bata, Guinea Ecuatorial, en el periodo septiembre 2002 a Junio 2003, se realizó un estudio descriptivo y prospectivo. En el mismo se encontró que el grado de parasitismo intestinal fue de un 29.9 % del total de análisis realizados, predominando sobre todo en los menores de 6 años; un 44.7% de éstos estaban infestados. Se encontró un predominio de los vermes: el más frecuente fue Trichuris trichiura, para el 95.1 % del total de niños infestados, y el áscaris lumbricoides, con un 75.6% del total de 41 infestados. De los protozoos, el más frecuente fue la ameba, existiendo en un 17.07 % de los infestados. El grado de infestación encontrado es elevado, requiriéndose programas educativos para fomentar el cuidado de los hábitos higiénicos de los niños. El predominio de los parásitos encontrados podría deberse a la contaminación de la tierra con heces fecales y a la falta de un adecuado tratamiento de las aguas para el consumo, y de infraestructura sanitaria.With the aim of defining exactly the grade of intestinal parasitism according to age, as well as identifying the most frequent intestinal parasites in "Amiguitos de Jesús" Elementary School in Bata City, Equatorial Guinea, during septembre 2002 to June 2003, a descriptive, prospective study is carried out. In the study it was found that the parasitism grade was 29.9% from the total of the analysis performed, predominating in those under 6 years of age: 44.7% of these cases were infected. A prevalence of vermes was observed, Trichuris trichiuria was the most frequent species found, representing 95,1% from the total of infected children and Ascaris lumbricoides 75,6% from the total of 41 infected. Among protozoa, amoeba was the most frequent specie observed, being present in 17

  2. Condor equatorial electrojet campaign: Radar results

    International Nuclear Information System (INIS)

    Kudeki, E.; Fejer, B.G.; Farley, D.T.; Hanuise, C.

    1987-01-01

    A review of the experimental and theoretical background to the Condor equatorial electrojet compaign is followed by the presentation and discussion of VHF radar interferometer and HF radar backscatter data taken concurrently with two rocket in situ experiments reported in companion papers (Pfaff et al., this issue (a, b). Both experiments were conducted in strongly driven periods with the on-line radar interferometer displaying signatures of what has been interpreted in earlier radar work (Kudeki et al., 1982) as kilometer scale gradient drift waves. Low-frequency density fluctuations detected by in situ rocket sensors confirm the earlier interpretation. VHF radar/rocket data comparisons also indicate the existence of a turbulent layer in the upper portion of the daytime electrojet at about 108 km altitude driven purely by the two-stream instability. Nonlinear mode coupling of linearly growing two-stream waves to linearly damped 3-m vertical modes could account for the radar echoes scattered from this layer, which showed no indication of large-scale gradient drift waves. Nonlinear mode coupling may therefore compete with the wave-induced anomalous diffusion mechanism proposed recently by Sudan (1983) for the saturation of directly excited two-stream waves. Nighttime radar data show a bifurcated layer with the two parts having comparable echo strength but oppositely directed zonal drift velocities. The lower layer shows narrow backscatter spectra; the upper layer is characterized by kilometer scale waves and vertically propagating type 1 waves

  3. HIV-1 Variants and Drug Resistance in Pregnant Women from Bata (Equatorial Guinea): 2012-2013.

    Science.gov (United States)

    Alvarez, Patricia; Fernández McPhee, Carolina; Prieto, Luis; Martín, Leticia; Obiang, Jacinta; Avedillo, Pedro; Vargas, Antonio; Rojo, Pablo; Benito, Agustín; Ramos, José Tomás; Holguín, África

    2016-01-01

    This is the first study describing drug resistance mutations (DRM) and HIV-1 variants among infected pregnant women in Equatorial Guinea (GQ), a country with high (6.2%) and increasing HIV prevalence. Dried blood spots (DBS) were collected from November 2012 to December 2013 from 69 HIV-1 infected women participating in a prevention of mother-to-child transmission program in the Hospital Regional of Bata and Primary Health Care Centre María Rafols, Bata, GQ. The transmitted (TDR) or acquired (ADR) antiretroviral drug resistance mutations at partial pol sequence among naive or antiretroviral therapy (ART)-exposed women were defined following WHO or IAS USA 2015 lists, respectively. HIV-1 variants were identified by phylogenetic analyses. A total of 38 of 69 HIV-1 specimens were successfully amplified and sequenced. Thirty (79%) belonged to ART-experienced women: 15 exposed to nucleoside reverse transcriptase inhibitors (NRTI) monotherapy, and 15 to combined ART (cART) as first regimen including two NRTI and one non-NRTI (NNRTI) or one protease inhibitor (PI). The TDR rate was only found for PI (3.4%). The ADR rate was 37.5% for NNRTI, 8.7% for NRTI and absent for PI or NRTI+NNRTI. HIV-1 group M non-B variants caused most (97.4%) infections, mainly (78.9%) recombinants: CRF02_AG (55.2%), CRF22_A101 (10.5%), subtype C (10.5%), unique recombinants (5.3%), and A3, D, F2, G, CRF06_cpx and CRF11_cpx (2.6% each). The high rate of ADR to retrotranscriptase inhibitors (mainly to NNRTIs) observed among pretreated pregnant women reinforces the importance of systematic DRM monitoring in GQ to reduce HIV-1 resistance transmission and to optimize first and second-line ART regimens when DRM are present.

  4. Accuracy of an Immunochromatographic Diagnostic Test (ICT Malaria Combo Cassette Test) Compared to Microscopy among under Five-Year-Old Children when Diagnosing Malaria in Equatorial Guinea

    Science.gov (United States)

    Portero, José-Luis; Rubio-Yuste, Maria; Descalzo, Miguel Angel; Raso, Jose; Lwanga, Magdalena; Obono, Jaquelina; Nseng, Gloria; Benito, Agustin; Cano, Jorge

    2010-01-01

    Conventional malaria diagnosis based on microscopy raises serious difficulties in weak health systems. Cost-effective and sensitive rapid diagnostic tests have been recently proposed as alternatives to microscopy. In Equatorial Guinea, a study was conducted to assess the reliability of a rapid diagnostic test compared to microscopy. The study was designed in accordance with the directives of the Standards for Reporting Diagnostic Accuracy Initiative (STARD). Peripheral thick and thin films for the microscopy diagnosis and a rapid immunochromatographic test (ICT Malaria Combo Cassette Test) were performed on under five-year-old children with malaria suspicion. The ICT test detected Plasmodium spp. infection with a sensitivity of 81.5% and a specificity of 81.9% while P. falciparum diagnosis occurred with a sensitivity of 69.7% and a specificity of 73.7%. The sensitivity of the ICT test increased with higher parasitemias. The general results showed little concordance between the ICT test and microscopy (kappa = 0.28, se: 0.04). In Equatorial Guinea, the ICT Malaria Combo Cassette Test has proven to be an acceptable test to detect high P. falciparum parasitemias. However, the decrease of sensitivity at medium and low parasitemias hampers that ICT can replace properly performed microscopy at present in the diagnosis of malaria in children. PMID:22332024

  5. Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea.

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    Laura Moya

    2016-07-01

    Full Text Available Onchocerciasis or "river blindness" is a chronic parasitic neglected tropical disease which is endemic both in mainland and insular Equatorial Guinea. We aim to estimate the current epidemiological situation of onchocerciasis in Bioko Island after vector elimination in 2005 and more than sixteen years of Community Directed Treatment with Ivermectin (CDTI by using molecular and serological approaches for onchocerciasis diagnosis. A community-based cross-sectional study was carried out in Bioko Island from mid-January to mid-February 2014. A total of 544 study participants were recruited. A complete dermatological examination was performed and three skin snips were performed in every participant for parasitological and molecular assessments. Blood spots were also taken for determination of Ov16 IgG4 antibodies trough an "in-house" ELISA assay. Overall, we found 15 out of 522 individuals suffering any onchocerciasis specific cutaneous lesions and 16 out of 528 (3.0% with onchocercal nodules in the skin. Nodules were significantly associated with age, being more common in subjects older than 10 years than in younger people (3.9% vs. 0%, p = 0.029. Regarding the onchocerciasis laboratory assessment, no positive parasitological test for microfilaria detection was found in the skin snips. The calculated seroprevalence through IgG4 serology was 7.9%. No children less than 10 years old were found to be positive for this test. Only one case was positive for Onchocerca volvulus (O. volvulus after skin PCR. The present study points out that the on-going mass ivermectin treatment has been effective in reducing the prevalence of onchocerciasis and corroborates the interruption of transmission in Bioko Island. To our knowledge, this is the first time that accurate information through molecular and serological techniques is generated to estimate the onchocerciasis prevalence in this zone. Sustained support from the national program and appropriate communication

  6. Description of HIV-1 Group M Molecular Epidemiology and Drug Resistance Prevalence in Equatorial Guinea from Migrants in Spain

    Science.gov (United States)

    Yebra, Gonzalo; de Mulder, Miguel; Holguín, África

    2013-01-01

    Background The HIV epidemic is increasing in Equatorial Guinea (GQ), West Central Africa, but few studies have reported its HIV molecular epidemiology. We aimed to describe the HIV-1 group M (HIV-1M) variants and drug-resistance mutations in GQ using sequences sampled in this country and in Spain, a frequent destination of Equatoguinean migrants. Methods We collected 195 HIV-1M pol sequences from Equatoguinean subjects attending Spanish clinics during 1997-2011, and 83 additional sequences sampled in GQ in 1997 and 2008 from GenBank. All (n = 278) were re-classified using phylogeny and tested for drug-resistance mutations. To evaluate the origin of CRF02_AG in GQ, we analyzed 2,562 CRF02_AG sequences and applied Bayesian MCMC inference (BEAST program). Results Most Equatoguinean patients recruited in Spain were women (61.1%) or heterosexuals (87.7%). In the 278 sequences, the variants found were CRF02_AG (47.8%), A (13.7%), B (7.2%), C (5.8%), G (5.4%) and others (20.1%). We found 6 CRF02_AG clusters emerged from 1983.9 to 2002.5 with origin in GQ (5.5 sequences/cluster). Transmitted drug-resistance (TDR) rate among naïve patients attended in Spain (n = 144) was 4.7%: 3.4% for PI (all with M46IL), 1.8% for NRTI (all with M184V) and 0.9% for NNRTI (Y188L). Among pre-treated patients, 9/31 (29%) presented any resistance, mainly affecting NNRTI (27.8%). Conclusions We report a low (HIV-1M variant and entered GQ through independent introductions at least since the early 1980s. PMID:23717585

  7. Contrasts in livelihoods and protein intake between commercial and subsistence bushmeat hunters in two villages on Bioko Island, Equatorial Guinea.

    Science.gov (United States)

    Vega, María Grande; Carpinetti, Bruno; Duarte, Jesús; Fa, John E

    2013-06-01

    Across West and Central Africa, wildlife provides a source of food and income. We investigated the relation between bushmeat hunting and household wealth and protein consumption in 2 rural communities in Bioko Island, Equatorial Guinea. One village was dedicated to commercial hunting, the other trapped game primarily for food. We tested whether commercial-hunter households were nutritionally advantaged over subsistence-hunter households due to their higher income from the bushmeat trade and greater access to wild-animal protein. We conducted bushmeat-offtake surveys in both villages (captures by hunters and carcasses arriving to each village). Mammals (including threatened primates: black colobus [Colobus satanas], Preussi's guenon [Allochrocebus preussi], and russet-eared guenon [Cercopithecus erythrotis]), birds, and reptiles were hunted. The blue duiker (Philantomba monticola), giant pouched rat (Cricetomys emini), and brush-tailed porcupine (Atherurus africanus) contributed almost all the animal biomass hunted, consumed, or sold in both villages. Monkeys and Ogilbyi's duikers (Cephalophus ogilbyi) were hunted only by commercial hunters. Commercial hunters generated a mean of US$2000/year from bushmeat sales. Households with commercial hunters were on average wealthier, generated more income, spent more money on nonessential goods, and bought more products they did not grow. By contrast, households with subsistence hunters spent less on market items, spent more on essential products, and grew more of their own food. Despite these differences, average consumption of vegetable protein and domestic meat and bushmeat protein did not differ between villages. Our results highlight the importance of understanding the socioeconomic and nutritional context of commercial and subsistence bushmeat hunting to correctly interpret ways of reducing their effects on threatened species and to enable the sustainable offtake of more productive taxa. © 2013 Society for Conservation

  8. Prevalence of anemia and associated factors in children living in urban and rural settings from Bata District, Equatorial Guinea, 2013.

    Science.gov (United States)

    Ncogo, Policarpo; Romay-Barja, Maria; Benito, Agustin; Aparicio, Pilar; Nseng, Gloria; Berzosa, Pedro; Santana-Morales, Maria A; Riloha, Matilde; Valladares, Basilio; Herrador, Zaida

    2017-01-01

    Anemia in children under 5 years of age is a global public health problem. According to the World Health Organization the current rate of anemia among preschool aged children in Equatorial Guinea is 66%. No information is available above this age. The cross-sectional Prevamal Survey was conducted in 2013 aimed at providing baseline data on malaria prevalence in children aged 2 months-15 years old. Sampling was carried out with the use of a multistage, stratified cluster strategy in the district of Bata, Equatorial Guinea. The χ2 test and adjusted Poisson regression models were applied to assess the association between social-demographic and economic factors, malaria and anemia. A total of 1436 children were tested, out of which 1,421 children (99%) were tested for anemia. Over 85% were anemic; out of them, 284 (24%), 815 (67%) and 111 (9%) children had mild, moderate and severe anemia, respectively. Severe anemia was more frequent among children aged 2-12 months old and those living in rural sites. About 47% tested positive for malaria via a rapid diagnostic test (RDT). This rate was significantly higher in rural villages (66%; panemia and malaria was higher in rural settings (panemia in urban areas displayed a heterogeneity and complexity that differed from the rural environment: in urban neighbourhoods, children with concomitant malaria infection were more likely to be anemic (adjusted prevalence rate (aPR):1.19; CI 95%: 1.12-1.28). Moreover, the prevalence of anemia was higher in children aged above 13 months compared to younger children (pchildren' parents being employees (aPR: 0.86, 95% CI: 0.76-0.96) or self-employed (aPR: 0.86, 95% CI: 0.76-0.97) vs. working in agriculture and/or fishing negatively associated with anemia among urban children. This marked urban-rural variation indicates the importance of targeting specific areas or districts. Strategies aimed at reducing malaria are clearly paramount in this country. Prevention and treatment of other factors

  9. Prevalence of anemia and associated factors in children living in urban and rural settings from Bata District, Equatorial Guinea, 2013.

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    Policarpo Ncogo

    Full Text Available Anemia in children under 5 years of age is a global public health problem. According to the World Health Organization the current rate of anemia among preschool aged children in Equatorial Guinea is 66%. No information is available above this age. The cross-sectional Prevamal Survey was conducted in 2013 aimed at providing baseline data on malaria prevalence in children aged 2 months-15 years old. Sampling was carried out with the use of a multistage, stratified cluster strategy in the district of Bata, Equatorial Guinea. The χ2 test and adjusted Poisson regression models were applied to assess the association between social-demographic and economic factors, malaria and anemia. A total of 1436 children were tested, out of which 1,421 children (99% were tested for anemia. Over 85% were anemic; out of them, 284 (24%, 815 (67% and 111 (9% children had mild, moderate and severe anemia, respectively. Severe anemia was more frequent among children aged 2-12 months old and those living in rural sites. About 47% tested positive for malaria via a rapid diagnostic test (RDT. This rate was significantly higher in rural villages (66%; p<0.001. The prevalence of anemia and malaria was higher in rural settings (p<0.001. On the other hand, anemia in urban areas displayed a heterogeneity and complexity that differed from the rural environment: in urban neighbourhoods, children with concomitant malaria infection were more likely to be anemic (adjusted prevalence rate (aPR:1.19; CI 95%: 1.12-1.28. Moreover, the prevalence of anemia was higher in children aged above 13 months compared to younger children (p<0.005. Belonging to the poorest wealth tertile were positively (aPR: 1.14, 95% CI: 1.05-1.24 and children' parents being employees (aPR: 0.86, 95% CI: 0.76-0.96 or self-employed (aPR: 0.86, 95% CI: 0.76-0.97 vs. working in agriculture and/or fishing negatively associated with anemia among urban children. This marked urban-rural variation indicates the

  10. A new subtype of hepatitis C virus genotype 1: complete genome and phylogenetic relationships of an Equatorial Guinea isolate.

    Science.gov (United States)

    Bracho, Maria Alma; Carrillo-Cruz, Francy Yolima; Ortega, Enrique; Moya, Andrés; González-Candelas, Fernando

    2006-06-01

    Hepatitis C virus (HCV) is the leading cause of chronic liver disease and is associated with hepatocellular carcinoma. However, there have been few studies on the distribution and genetic diversity of HCV isolates in non-developed countries. Here, the complete genome sequence of an HCV genotype 1 isolate from Equatorial Guinea is reported, the first complete HCV-1 genome of African origin. Phylogenetic analysis revealed that this sequence always grouped with sequences of genotype 1, but did not group clearly with any subtype described so far. An analysis of partial NS5B gene sequences with additional sequences of African origin also failed to find close similarities between the new sequence and any previously known isolate. Genetic divergence of the coding region of this new sequence with respect to the recognized subtypes of HCV-1 ranged from 20 to 22%. It is proposed that this isolate is a representative of a new, distinct variant of HCV subtype 1.

  11. Spatial variability in the density, distribution and vectorial capacity of anopheline species in a high transmission village (Equatorial Guinea

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    Buatiche Jesús N

    2006-03-01

    Full Text Available Abstract Background Malaria transmission varies from one country to another and there are also local differences in time and space. An important variable when explaining the variability in transmission is the breeding behaviour of the different vector species and the availability of breeding sites. The aim of this study was to determine the geographical variability of certain entomological parameters: human biting rate (HBR, sporozoitic index (SI for Plasmodium falciparum and entomological inoculation rate (EIR. Methods The study was carried out in a small village in the mainland region of Equatorial Guinea. Adult mosquitoes were collected by CDC light traps. Polymerase Chain Reaction was employed to identify the species within the Anopheles gambiae complex and to detect P. falciparum sporozoites. The geographical position of all the dwellings in the village were taken using a global positioning system receiver unit. Data relating to the dwelling, occupants, use of bednets and the mosquitoes collection data were used to generate a geographical information system (GIS. This GIS allowed the minimum distance of the dwellings to the closest water point (potential breeding sites to be determined. Results A total of 1,173 anophelines were caught: 279 A. gambiae s.l. (217 A. gambiae s.s. and one Anopheles melas, 777 Anopheles moucheti and 117 Anopheles carnevalei. A. moucheti proved to be the main vector species and was responsible for 52.38 [95% IC: 33.7–71] night infective bites during this period. The highest SI was found in A. carnevalei (24%, even though the HBR was the lowest for this species. A significant association was found between the distance from the dwellings to the closest water point (River Ntem or secondary streams and the total HBR. Conclusion A clear association has been observed between the distance to potential breeding sites and the variability in the anopheline density, while the other parameters measured do not seem to

  12. The genetic landscape of Equatorial Guinea and the origin and migration routes of the Y chromosome haplogroup R-V88

    OpenAIRE

    González, Miguel; Gomes, Verónica; López-Parra, Ana Maria; Amorim, António; Carracedo, Ángel; Sánchez-Diz, Paula; Arroyo-Pardo, Eduardo; Gusmão, Leonor

    2012-01-01

    Human Y chromosomes belonging to the haplogroup R1b1-P25, although very common in Europe, are usually rare in Africa. However, recently published studies have reported high frequencies of this haplogroup in the central-western region of the African continent and proposed that this represents a ‘back-to-Africa' migration during prehistoric times. To obtain a deeper insight into the history of these lineages, we characterised the paternal genetic background of a population in Equatorial Guinea,...

  13. Duffy Negative Antigen Is No Longer a Barrier to Plasmodium vivax – Molecular Evidences from the African West Coast (Angola and Equatorial Guinea)

    Science.gov (United States)

    Mendes, Cristina; Dias, Fernanda; Figueiredo, Joana; Mora, Vicenta Gonzalez; Cano, Jorge; de Sousa, Bruno; do Rosário, Virgílio E.; Benito, Agustin; Berzosa, Pedro; Arez, Ana Paula

    2011-01-01

    Background Plasmodium vivax shows a small prevalence in West and Central Africa due to the high prevalence of Duffy negative people. However, Duffy negative individuals infected with P. vivax have been reported in areas of high prevalence of Duffy positive people who may serve as supply of P. vivax strains able to invade Duffy negative erythrocytes. We investigated the presence of P. vivax in two West African countries, using blood samples and mosquitoes collected during two on-going studies. Methodology/Findings Blood samples from a total of 995 individuals were collected in seven villages in Angola and Equatorial Guinea, and 820 Anopheles mosquitoes were collected in Equatorial Guinea. Identification of the Plasmodium species was achieved by nested PCR amplification of the small-subunit rRNA genes; P. vivax was further characterized by csp gene analysis. Positive P. vivax-human isolates were genotyped for the Duffy blood group through the analysis of the DARC gene. Fifteen Duffy-negative individuals, 8 from Equatorial Guinea (out of 97) and 7 from Angola (out of 898), were infected with two different strains of P. vivax (VK210 and VK247). Conclusions In this study we demonstrated that P. vivax infections were found both in humans and mosquitoes, which means that active transmission is occurring. Given the high prevalence of infection in mosquitoes, we may speculate that this hypnozoite-forming species at liver may not be detected by the peripheral blood samples analysis. Also, this is the first report of Duffy negative individuals infected with two different strains of P. vivax (VK247 and classic strains) in Angola and Equatorial Guinea. This finding reinforces the idea that this parasite is able to use receptors other than Duffy to invade erythrocytes, which may have an enormous impact in P. vivax current distribution. PMID:21713024

  14. Molecular Evidence of a Trypanosoma brucei gambiense Sylvatic Cycle in the Human African Trypanosomiasis Foci of Equatorial Guinea

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    Carlos eCordon-Obras

    2015-07-01

    Full Text Available Gambiense trypanosomiasis is considered an anthroponotic disease. Consequently, control programs are generally aimed at stopping transmission of Trypanosoma brucei gambiense (T. b. gambiense by detecting and treating human cases. However, the persistence of numerous foci despite efforts to eliminate this disease questions this strategy as unique tool to pursue the eradication. The role of animals as a reservoir of T. b. gambiense is still controversial, but could partly explain maintenance of the infection at hypo-endemic levels. In the present study, we evaluated the presence of T. b. gambiense in wild animals in Equatorial Guinea. The infection rate ranged from 0.8% in the insular focus of Luba to more than 12% in Mbini, a focus with a constant trickle of human cases. The parasite was detected in a wide range of animal species including four species never described previously as putative reservoirs. Our study comes to reinforce the hypothesis that animals may play a role in the persistence of T. b. gambiense transmission, being particularly relevant in low transmission settings. Under these conditions the integration of sustained vector control and medical interventions should be considered to achieve the elimination of Gambiense trypanosomiasis.

  15. Integrating occurrence and detectability patterns based on interview data: a case study for threatened mammals in Equatorial Guinea

    Science.gov (United States)

    Martínez-Martí, Chele; Jiménez-Franco, María V.; Royle, J. Andrew; Palazón, José A.; Calvo, José F.

    2016-01-01

    Occurrence models that account for imperfect detection of species are increasingly used for estimating geographical range, for determining species-landscape relations and to prioritize conservation actions worldwide. In 2010, we conducted a large-scale survey in Río Muni, the mainland territory of Equatorial Guinea, which aimed to estimate the probabilities of occurrence and detection of threatened mammals based on environmental covariates, and to identify priority areas for conservation. Interviews with hunters were designed to record presence/absence data of seven species (golden cat, leopard, forest elephant, forest buffalo, western gorilla, chimpanzee and mandrill) in 225 sites throughout the region. We fitted single season occupancy models and recently developed models which also include false positive errors (i.e. species detected in places where it actually does not occur), which should provide more accurate estimates for most species, which are susceptible to mis-identification. Golden cat and leopard had the lowest occurrence rates in the region, whereas primates had the highest rates. All species, except gorilla, were affected negatively by human settlements. The southern half of Río Muni showed the highest occurrence of the species studied, and conservation strategies for ensuring the persistence of threatened mammals should be focused on this area.

  16. Long-Term Urban Market Dynamics Reveal Increased Bushmeat Carcass Volume despite Economic Growth and Proactive Environmental Legislation on Bioko Island, Equatorial Guinea

    Science.gov (United States)

    Cronin, Drew T.; Woloszynek, Stephen; Morra, Wayne A.; Honarvar, Shaya; Linder, Joshua M.; Gonder, Mary Katherine; O’Connor, Michael P.; Hearn, Gail W.

    2015-01-01

    Bushmeat hunting is extensive in west and central Africa as both a means for subsistence and for commercial gain. Commercial hunting represents one of the primary threats to wildlife in the region, and confounding factors have made it challenging to examine how external factors influence the commercial bushmeat trade. Bioko Island, Equatorial Guinea is a small island with large tracts of intact forest that support sizeable populations of commercially valuable vertebrates, especially endemic primates. The island also has a low human population and has experienced dramatic economic growth and rapid development since the mid-1990’s. From October 1997 – September 2010, we monitored the largest bushmeat market on Bioko in Malabo, recording over 197,000 carcasses for sale. We used these data to analyze the dynamics of the market in relation to political events, environmental legislation, and rapid economic growth. Our findings suggest that bushmeat hunting and availability increased in parallel with the growth of Equatorial Guinea’s GDP and disposable income of its citizens. During this 13-year study, the predominant mode of capture shifted from trapping to shotguns. Consequently, carcass volume and rates of taxa typically captured with shotguns increased significantly, most notably including intensified hunting of Bioko's unique and endangered monkey fauna. Attempts to limit bushmeat sales, including a 2007 ban on primate hunting and trade, were only transiently effective. The hunting ban was not enforced, and was quickly followed by a marked increase in bushmeat hunting compared to hunting rates prior to the ban. Our results emphasize the negative impact that rapid development and unenforced legislation have had on Bioko’s wildlife, and demonstrate the need for strong governmental support if conservation strategies are to be successful at preventing extinctions of tropical wildlife. PMID:26230504

  17. Equatorial spread F: a review of recent experimental results

    International Nuclear Information System (INIS)

    Kelley, M.C.

    1979-01-01

    In this paper the authors review an intense research effort aimed at understanding the large scale disruption of the equatorial F layer which often commences just after sunset, and lasts for most of the night. A very attractive explanation for the phenomena, although one not universally accepted, is that the F layer is unstable to the classic Rayleigh-Taylor condition in which a heavy fluid, the plasma, is supported against gravity by a light 'fluid', the Earth's magnetic field. It is concluded that a reasonable case has been made for this explanation provided that the concept is extended to include nonlinear Rayleigh-Taylor like buoyancy effects above the F peak where linear process is stable. Internal gravity waves in neutral atmosphere seem to play an important role in seeding the Rayleigh-Taylor process with large scale finite amplitude perturbations. One of the remarkable features of this phenomena is the nearly simultaneous generation of structure with scale sizes spanning five orders of magnitude. These results may have applications in astrophysical processes where the Rayleigh-Taylor instability is thought to play a role. (Auth.)

  18. Nutritional status and its correlates in Equatorial Guinean preschool children: results from a nationally representative survey.

    Science.gov (United States)

    Custodio, Estefanía; Descalzo, Miguel Angel; Roche, Jesús; Sánchez, Ignacio; Molina, Laura; Lwanga, Magdalena; Bernis, Cristina; Villamor, Eduardo; Baylin, Ana

    2008-03-01

    In Equatorial Guinea, as a result of the recent growth of the oil industry, there is an opportunity to address important public health problems through public and private initiatives. To propose effective nutrition and public health strategies, it is important first to have reliable information on the nutritional status of the population and the underlying factors affecting it. To assess the nutritional status and the prevalence of anemia among Equatoguinean children in a nationally representative sample and to identify the risk factors associated with the nutritional problems detected. The study was a cross-sectional survey using a multistaged, stratified, cluster-selected sample. The survey included a sociodemographic, health, and dietary questionnaire and measurement of hematocrit and anthropometric features, from which nutritional indicators based on the National Center for Health Statistics (NCHS) reference and the World Health Organization (WHO) standards were calculated. Logistic regression models were used for the multivariate analysis. A total of 552 children aged 0 to 60 months were surveyed. The overall prevalence of stunting (hemoglobin hemoglobin education, should be undertaken.

  19. Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa

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    Pilar Charle

    2009-01-01

    Full Text Available Objectives. The objectives of the study were (i to evaluate the efficacy of combination drugs, such as artesunate + sulphadoxine-pyrimethamine (AS + SP and amodiaquine + sulphadoxine-pyripethamine (AQ + SP in treatment of uncomplicated falciparum malaria (ii to differentiate recrudescence from reinfection by analysing msp-1 and msp-2 genes of Plasmodium falciparum in treatment failure cases. Methods. We carried out an in vivo study in the year 2005 in 206 children between 6 to 59 months age groups. Of the 206, 120 received AQ + SP, and 86 received AS + SP. A clinical and parasitological followup during 14 days was undertaken. Finger-prick blood sample from each patient was taken on Whatman filter paper (no. 3 on days 0, 7, 14 and also the day when the parasite and symptoms reappeared for PCR analysis. Results. Late treatment failure was observed in 3.5% (4/114 with AQ + SP, and 2.5% (2/79 with AS + SP. The success rate was 96.5% with AQ + SP and 97.5% with AS + SP. No deaths and severe reactions were recorded. Out of the 6 treatment failure cases, one was reinfection as observed by PCR analysis of msp-1 and msp-2 genes on day 14. Discussion. Both the combinations found to be efficacious and safe and could be used as a first-line treatment for uncomplicated falciparum malaria in Equatorial Guinea.

  20. Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea.

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    Zaida Herrador

    2018-05-01

    Full Text Available Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA have been met.A cross-sectional study was conducted from September 2016 to January 2017. Participants were 5- to 9-year-old school children. Onchocerciasis/lymphatic Filariasis (LF, only in endemic districts rapid diagnostic tests (RDTs were performed. Blood spots were collected from RDT positive children and 10 percent of the RDT negatives to determine Ov16 and Wb123 IgG4 antibodies through enzyme-linked immunosorbent assay (ELISA. Skin snips were collected from RDT positives. Filarial detection was performed by PCR in positives and indeterminate sera. Black fly collection was carried out in traditional breeding sites. A total of 7,052 children, ranging from 5 to 9 years of age, were included in the study. Four children (0.06% were Ov16 IgG4 RDT positives, but negative by ELISA Ov16, while 6 RDT negative children tested positive by ELISA. A total of 1,230 children from the Riaba and Baney districts were tested for LF. One child was Wb123 RDT positive (0.08%, but ELISA negative, while 3 RDT negative children were positive by Wb123 ELISA. All positive samples were negative by PCR for onchocerciasis and LF (in blood spot and skin snip. All fly collections and larval prospections in the traditional catching and prospection sites were negative.WHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection.

  1. Rural-Urban Differences in Household Treatment-Seeking Behaviour for Suspected Malaria in Children at Bata District, Equatorial Guinea.

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    Maria Romay-Barja

    Full Text Available Malaria remains a major cause of morbidity and mortality among children under five years old in Equatorial Guinea. However, little is known about the community management of malaria and treatment-seeking patterns. We aimed to assess symptoms of children with reported malaria and treatment-seeking behaviour of their caretakers in rural and urban areas in the Bata District.A cross-sectional study was conducted in the district of Bata and 440 houses were selected from 18 rural villages and 26 urban neighbourhoods. Differences between rural and urban caregivers and children with reported malaria were assessed through the chi-squared test for independence of categorical variables and the t-Student or the non-parametric Mann-Whitney test for normally or not-normally distributed continuous variables, respectively.Differences between rural and urban households were observed in caregiver treatment-seeking patterns. Fever was the main symptom associated with malaria in both areas. Malaria was treated first at home, particularly in rural areas. The second step was to seek treatment outside the home, mainly at hospital and Health Centre for rural households and at hospital and private clinic for urban ones. Artemether monotherapy was the antimalarial treatment prescribed most often. Households waited for more than 24 hours before seeking treatment outside and delays were longest in rural areas. The total cost of treatment was higher in urban than in rural areas in Bata.The delays in seeking treatment, the type of malaria therapy received and the cost of treatment are the principal problems found in Bata District. Important steps for reducing malaria morbidity and mortality in this area are to provide sufficient supplies of effective antimalarial drugs and to improve malaria treatment skills in households and in both public and private sectors.

  2. [Initial evaluation of a programme to prevent mother-to-child transmission of human immunodeficiency virus infection in Equatorial Guinea].

    Science.gov (United States)

    Badillo-Navarro, Katie; Prieto-Tato, Luis; Obiang-Esomoyo, Jacinta; Avedillo-Jiménez, Pedro; Vargas-Brizuela, Antonio; Rojo-Conejo, Pablo

    2014-01-01

    The prevalence of human immunodeficiency virus (HIV)-infected pregnant women in Equatorial Guinea (EG) has been reported as 7.3%. In 2008 an updated version of the PMTCT protocol was accepted according to the current WHO guidelines. The aim of this study was to describe the characteristics and outcome of children exposed to HIV after the introduction of the protocol. A retrospective review was conducted on the clinical characteristics of the infants born to HIV-infected mothers in the Hospital Regional de Bata and Primary Health Care Centre Maria Rafols in Bata (EG) between June 2008 and November 2011. The diagnosis of HIV infection in children was based on rapid serology tests. A total of 103 children were included, of which 47 were males. Fifty three patients (51%) completed the follow-up (51%). Fourteen children (26%) were diagnosed with HIV infection (11 presumptive diagnosis, 3 due to persistence of antibodies at 18 months). Six children (12%) died before a definitive diagnosis. Just over than half (52%) of mothers received antiretroviral therapy (ART) during pregnancy. The transmission rate in children whose mothers received ART was 16% (3/19), compared with 43% (10/23) in children whose mothers did not receive it. Only one child was infected (8%) when the mother received ART, and child received postnatal prophylaxis. The PMTCT protocol compliance was still very low. Antiretroviral therapy in pregnant women decreased the rate of vertical transmission, but the rate still remains very high. Many children were lost to follow-up. Strategies to prevent loss to follow-up and methods for earlier virological diagnostic are needed. Copyright © 2012 Elsevier España, S.L. All rights reserved.

  3. The genetic landscape of Equatorial Guinea and the origin and migration routes of the Y chromosome haplogroup R-V88.

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    González, Miguel; Gomes, Verónica; López-Parra, Ana Maria; Amorim, António; Carracedo, Angel; Sánchez-Diz, Paula; Arroyo-Pardo, Eduardo; Gusmão, Leonor

    2013-03-01

    Human Y chromosomes belonging to the haplogroup R1b1-P25, although very common in Europe, are usually rare in Africa. However, recently published studies have reported high frequencies of this haplogroup in the central-western region of the African continent and proposed that this represents a 'back-to-Africa' migration during prehistoric times. To obtain a deeper insight into the history of these lineages, we characterised the paternal genetic background of a population in Equatorial Guinea, a Central-West African country located near the region in which the highest frequencies of the R1b1 haplogroup in Africa have been found to date. In our sample, the large majority (78.6%) of the sequences belong to subclades in haplogroup E, which are the most frequent in Bantu groups. However, the frequency of the R1b1 haplogroup in our sample (17.0%) was higher than that previously observed for the majority of the African continent. Of these R1b1 samples, nine are defined by the V88 marker, which was recently discovered in Africa. As high microsatellite variance was found inside this haplogroup in Central-West Africa and a decrease in this variance was observed towards Northeast Africa, our findings do not support the previously hypothesised movement of Chadic-speaking people from the North across the Sahara as the explanation for these R1b1 lineages in Central-West Africa. The present findings are also compatible with an origin of the V88-derived allele in the Central-West Africa, and its presence in North Africa may be better explained as the result of a migration from the south during the mid-Holocene.

  4. Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus, Hepatitis C Virus, and Treponema pallidum Infections among Blood Donors on Bioko Island, Equatorial Guinea.

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    Dong-De Xie

    Full Text Available Regular screening of transfusion-transmissible infections (TTIs, such as human immunodeficiency virus (HIV, hepatitis B and hepatitis C virus (HBV and HCV, respectively, and Treponema pallidum, in blood donors is essential to guaranteeing clinical transfusion safety. This study aimed to determine the seroprevalence of four TTIs among blood donors on Bioko Island, Equatorial Guinea (EG.A retrospective survey of blood donors from January 2011 to April 2013 was conducted to assess the presence of HIV, HBV, HCV and T. pallidum. The medical records were analyzed to verify the seroprevalence of these TTIs among blood donations stratified by gender, age and geographical region.Of the total 2937 consecutive blood donors, 1098 (37.39% had a minimum of one TTI and 185 (6.29% harbored co-infections. The general seroprevalence of HIV, HBV, HCV and T. pallidum were 7.83%, 10.01%, 3.71% and 21.51%, respectively. The most frequent TTI co-infections were HBV-T. pallidum 60 (2.04% and HIV-T. pallidum 46 (1.57%. The seroprevalence of HIV, HBV, HCV and T. pallidum were highest among blood donors 38 to 47 years, 18 to 27 years and ≥ 48 years age, respectively (P<0.05. The seroprevalence of TTIs varied according to the population from which the blood was collected on Bioko Island.Our results firstly provide a comprehensive overview of TTIs among blood donors on Bioko Island. Strict screening of blood donors and improved hematological examinations using standard operating procedures are recommended.

  5. Paludismo grave y complicado en niños. Hospital regional de Bata. Guinea Ecuatorial. 2003 Severe and complicated malaria in children at “Bata” Regional Hospital- Equatorial Guinea

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    Sandra Hernández García

    2005-09-01

    Full Text Available El paludismo grave es el causado por el Plasmodium falciparum, que cada año cobra millones de vidas en los países del tercer mundo, siendo los niños los más afectados, por este motivo se realizó estudio prospectivo, descriptivo transversal de los pacientes pediátricos que ingresaron con gota gruesa positiva a plasmodium falciparum, del mes de enero a julio del año 2003 en el hospital regional de Bata en Guinea Ecuatorial. Se encontró que el 49% de los ingresos correspondieron a los niños de 1-4 años, siguiendoles los menores de un año con 34,5% de casos. Se encontró que el 24% de los niños solo permanecieron un día en el hospital y el 67% de 2-5 días. Presentaron complicaciones 35,5% de los ingresados, la anemia severa fue la complicación que más se presentó (17,3%, los trastornos hidroelectrolíticos le siguieron con un 10%. Fallecieron 16 niños, de ellos con anemia severa 10 para (62,5%, con estadía de menos de un día fallecieron 7 pacientes y de 2-5 días otros 7 niños y entre los 6-13 días hubo 2 muertes. La principal recomendación fue que los niños con sospecha de paludismo deben ser atendidos inmediatamente para evitar las graves complicaciones de ésta enfermedad.Severe malaria is caused by Plasmodium falciparum taken millions of lives in Third World countries every year and being children the most affected. A descriptive, prospective, cross "sectional and correlational-casual study was carried out with pediatric patients who were admitted at Bata Regional Hospital in Equatorial Guinea after practicing a thick" film method test with positive results of plasmodium falciparum from January to July 2003, aimed at establishing clinical features of children affected by plasmodium falciparum determining the number of admissions, stay in hospital, complications and mortality, scientific methods used were empiric; analyzing documents and verbal interviews, statistic methods were: parametric samples and percentage

  6. Una aportación al estudio del cuento fang de Guinea Ecuatorial en lengua española / A CONTRIBUTION TO THE STUDY ABOUT THE FANG TALES FROM EQUATORIAL GUINEA IN SPANISH LANGUAGE

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    María Teresa Abaga Envó

    2009-06-01

    la Apertura y Cierre, la unidad argumental, la concentración en un personaje principal, la Ley de la Repetición, la Ley de Tres, la importancia de la posición inicial y final, la Ley de Dos en Escena, la Ley de Contraste y la Ley de Gemelos.Abstract: A revision about the narrative studies shows us that the narrative act is an inherent fact for the human being. “We are homo sapiens, because we are homo narrans”, as the academic José María Merino (2002 has said. Against the narrative structures, the traditional oral tale stands out as the most ancient. So old and so present in all the civilizations that semantic and formal components are repeated in tales from different cultures. Such aspects are the aim of our analysis about this compendium of fairy tales from Equatorial Guinea transmited in Spanish language. In this situation, the oral Fang tales appear like a living art. It is not an event only for children; all the community takes part in this “party” that will be exalted by the presence of the singing. Because there are not many studies about African oral tales (nor about Guinean tales, we compulsorily need to use Western studies, this fact takes us to the field of comparativism. However not always these studies are confirmed in this research which concluded with these results: the viewpoint of truth and fiction disappears (European studies use it to delimit some European traditional stories; the irregular use of formulas at the beginning and in the end; the ludic and the didactic purposes go together in fairy tales; the supposed universalization of the estructuralist method of Vladimir Propp, explained in Morphology of the Tale (1987, seems to be inoperative, because the thirty-one functions are reduced and because its lineal succesion. The themes and the motifs, covered by the spirit of the culture where they appear, are similar to themes and motifs identified in Spanish or International compilations. Finally the oral traditional nature of the

  7. [Early diagnosis of human immunodeficiency virus-1 in infants: The prevention of mother-to-child transmission program in Equatorial Guinea].

    Science.gov (United States)

    Prieto-Tato, Luis Manuel; Vargas, Antonio; Álvarez, Patrícia; Avedillo, Pedro; Nzi, Eugenia; Abad, Carlota; Guillén, Sara; Fernández-McPhee, Carolina; Ramos, José Tomás; Holguín, África; Rojo, Pablo; Obiang, Jacinta

    2016-11-01

    Great efforts have been made in the last few years in order to implement the prevention of mother-to-child transmission (PMTCT) program in Equatorial Guinea (GQ). The aim of this study was to evaluate the rates of mother-to-child HIV transmission based on an HIV early infant diagnosis (EID) program. A prospective observational study was performed in the Regional Hospital of Bata and Primary Health Care Centre Maria Rafols, Bata, GQ. Epidemiological, clinical, and microbiological characteristics of HIV-1-infected mothers and their exposed infants were recorded. Dried blood spots (DBS) for HIV-1 EID were collected from November 2012 to December 2013. HIV-1 genome was detected using Siemens VERSANT HIV-1 RNA 1.0 kPCR assay. Sixty nine pairs of women and infants were included. Sixty women (88.2%) had WHO clinical stage 1. Forty seven women (69.2%) were on antiretroviral treatment during pregnancy. Forty five infants (66.1%) received postnatal antiretroviral prophylaxis. Age at first DBS analysis was 2.4 months (IQR 1.2-4.9). One infant died before a HIV-1 diagnosis could be ruled out. Two infants were HIV-1 infected and started HAART before any symptoms were observed. The rate of HIV-1 transmission observed was 2.9% (95%CI 0.2-10.5). The PMTCT rate was evaluated for the first time in GQ based on EID. EID is the key for early initiation of antiretroviral therapy and to reduce the mortality associated with HIV infection. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  8. Prevalence of intestinal parasites in HIV-positive patients on the island of Bioko, Equatorial Guinea: its relation to sanitary conditions and socioeconomic factors.

    Science.gov (United States)

    Roka, Margarita; Goñi, Pilar; Rubio, Encarnación; Clavel, Antonio

    2012-08-15

    The prevalence of intestinal parasitic diseases and their associated factors has been investigated in HIV populations from the Island of Bioko, Equatorial Guinea. The feces of 310 participants from the island of Bioko (260 HIV-positive and 50 HIV-negative) were analyzed by microscopic observation. Immunochromatography was also used to diagnose Giardia, Entamoeba histolytica and Cryptosporidium spp. In addition, patients were asked for sociodemographic, economic and academic status, and CD4+ T cell counts were recorded. For HIV-positive patients, the prevalence of infection by intestinal parasites was 81.5% (212/260), 83.8% (218/260) by pathogenic helminths and 55.4% (168/260) by pathogenic protozoa (E. histolytica/dispar and Giardia duodenalis). Gender association was found between the infection by Ascaris and Schistosoma, a higher proportion being found in women; and between Entamoeba and the place of residence, a higher proportion being observed in the urban belt. Strongyloides stercoralis and Chilomastix mesnili appeared only in the people of this group, all the cases of Chilomastix being in females. For HIV-negative participants, the prevalence of infection by intestinal parasites was 74.0% (37/50), 90.0% (45/50) by pathogenic helminths and 66.0% (43/50) by pathogenic protozoa. Gender, educational level and low hygiene were associated with intestinal parasitic infection. When comparing the two groups (HIV-positive and HIV-negative), statistical association between HIV co-infection and infection by Giardia and Entamoeba was found. Diarrhea was also associated with intestinal parasitic infection in the HIV-positive group. Not only do our findings reflect high rates of intestinal parasitic infections in HIV-positive people, but also in the HIV-negative group, suggesting a closer relationship between sanitary status and living conditions than with immune status, and thus they highlight the need to carry out health education policies in the population. In addition

  9. Spleens and holoendemic malaria in West New Guinea.

    Science.gov (United States)

    METSELAAR, D

    1956-01-01

    The author describes the results obtained in recent malaria surveys in West New Guinea, where what is essentially holoendemic malaria prevails. However, the spleen-rate in adults differs markedly from what is regarded as normal under holoendemic conditions according to the definition put forward at the Malaria Conference in Equatorial Africa in 1950. The author therefore concludes that that definition is not properly applicable to New Guinea.

  10. Ocean Pollution as a Result of Onshore Offshore Petroleum Activities in the African Gulf of Guinea Region

    Science.gov (United States)

    Abubakar, B.

    2007-05-01

    The Gulf of Guinea region is located on the Atlantic side of Africa; the sub region has a total population of approximately 190million people. It comprises of five different countries and their territorial waters, which are as follows: Nigeria, Sao Tome & Principe, Equatorial Guinea, Gabon and Cameroon. The sub region is blessed with so many types of natural resources ranging from petroleum, Natural gas, Bitumen, Uranium Diamond and Gold to mention but a few. However the region since the last two decades started attracting the World's attention as a result of the continuous increasing discoveries of new oil fields on both its on shores and off shores. In view of this extra ordinary increasing discoveries of new oil fields in the region, the Gulf of Guinea has become a "Gold rush" to the oil companies and it has so far attracted almost all the top oil firms in the world including; Exxon Mobil, Shell, Total, Texaco, Agip, Chevron, Slumberger, Stat Oil and Conoco Phillips among many other oil giants. In the more recent time even the U.S. Marine Corp have stationed their War Ship in the territorial waters of the Gulf in the name of providing protection to the "Liquid Gold" (Petroleum) underlying the beneath of the region. OIL ACTIVITIES AND ITS ASSOCIATED PROBLEMS IN THE GULF OF GUINEA As a result of the geometrically increasing oil activities in the region ranging from Drilling, Gas flaring, Bunkering and Exploration activities, there was increase in the general pollution of the region. For example recent reports released in June, 2005 by the internationally renown nongovernmental organization on environmental pollution the Netherlands based Climate Justice programme and the Nigeria's Environmental Rights Action, Under the aegis of friends of the Earth, had it that the region is ranked top on the world's total flare with Nigeria along accounting for 16 percent of the world's total flare. Another example is the increasing cases of oil spillages leading to the

  11. New results on equatorial thermospheric winds and the midnight temperature maximum

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    J. Meriwether

    2008-03-01

    Full Text Available Optical observations of thermospheric winds and temperatures determined with high resolution measurements of Doppler shifts and Doppler widths of the OI 630-nm equatorial nightglow emission have been made with improved accuracy at Arequipa, Peru (16.4° S, 71.4° W with an imaging Fabry-Perot interferometer. An observing procedure previously used at Arecibo Observatory was applied to achieve increased spatial and temporal sampling of the thermospheric wind and temperature with the selection of eight azimuthal directions, equally spaced from 0 to 360°, at a zenith angle of 60°. By assuming the equivalence of longitude and local time, the data obtained using this technique is analyzed to determine the mean neutral wind speeds and mean horizontal gradients of the wind field in the zonal and meridional directions. The new temperature measurements obtained with the improved instrumental accuracy clearly show the midnight temperature maximum (MTM peak with amplitudes of 25 to 200 K in all directions observed for most nights. The horizontal wind field maps calculated from the mean winds and gradients show the MTM peak is always preceded by an equatorward wind surge lasting 1–2 h. The results also show for winter events a meridional wind abatement seen after the MTM peak. On one occasion, near the September equinox, a reversal was observed during the poleward transit of the MTM over Arequipa. Analysis inferring vertical winds from the observed convergence yielded inconsistent results, calling into question the validity of this calculation for the MTM structure at equatorial latitudes during solar minimum. Comparison of the observations with the predictions of the NCAR general circulation model indicates that the model fails to reproduce the observed amplitude by a factor of 5 or more. This is attributed in part to the lack of adequate spatial resolution in the model as the MTM phenomenon takes place within a scale of 300–500 km and ~45 min in

  12. Phase calibration approaches for radar interferometry and imaging configurations: equatorial spread F results

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    J. L. Chau

    2008-08-01

    Full Text Available In recent years, more and more radar systems with multiple-receiver antennas are being used to study the atmospheric and ionospheric irregularities with either interferometric and/or imaging configurations. In such systems, one of the major challenges is to know the phase offsets between the different receiver channels. Such phases are intrinsic to the system and are due to different cable lengths, filters, attenuators, amplifiers, antenna impedance, etc. Moreover, such phases change as function of time, on different time scales, depending on the specific installation. In this work, we present three approaches using natural targets (radio stars, meteor-head and meteor trail echoes that allow either an absolute or relative phase calibration. In addition, we present the results of using an artificial source (radio beacon for a continuous calibration that complements the previous approaches. These approaches are robust and good alternatives to other approaches, e.g. self-calibration techniques using known data features, or for multiple-receiver configurations constantly changing their receiving elements. In order to show the good performance of the proposed phase calibration techniques, we present new radar imaging results of equatorial spread F (ESF irregularities. Finally we introduce a new way to represent range-time intensity (RTI maps color coded with the Doppler information. Such modified map allows the identification and interpretation of geophysical phenomena, previously hidden in conventional RTI maps, e.g. the time and altitude of occurrence of ESF irregularities pinching off from the bottomside and their respective Doppler velocity.

  13. The STAFF-DWP wave instrument on the DSP equatorial spacecraft: description and first results

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    N. Cornilleau-Wehrlin

    2005-11-01

    Full Text Available The STAFF-DWP wave instrument on board the equatorial spacecraft (TC1 of the Double Star Project consists of a combination of 2 instruments which are a heritage of the Cluster mission: the Spatio-Temporal Analysis of Field Fluctuations (STAFF experiment and the Digital Wave-Processing experiment (DWP. On DSP-TC1 STAFF consists of a three-axis search coil magnetometer, used to measure magnetic fluctuations at frequencies up to 4 kHz and a waveform unit, up to 10 Hz, plus snapshots up to 180 Hz. DWP provides several onboard analysis tools: a complex FFT to fully characterise electromagnetic waves in the frequency range 10 Hz-4 kHz, a particle correlator linked to the PEACE electron experiment, and compression of the STAFF waveform data. The complementary Cluster and TC1 orbits, together with the similarity of the instruments, permits new multi-point studies. The first results show the capabilities of the experiment, with examples in the different regions of the magnetosphere-solar wind system that have been encountered by DSP-TC1 at the beginning of its operational phase. An overview of the different kinds of electromagnetic waves observed on the dayside from perigee to apogee is given, including the different whistler mode waves (hiss, chorus, lion roars and broad-band ULF emissions. The polarisation and propagation characteristics of intense waves in the vicinity of a bow shock crossing are analysed using the dedicated PRASSADCO tool, giving results compatible with previous studies: the broad-band ULF waves consist of a superimposition of different wave modes, whereas the magnetosheath lion roars are right-handed and propagate close to the magnetic field. An example of a combined Cluster DSP-TC1 magnetopause crossing is given. This first case study shows that the ULF wave power intensity is higher at low latitude (DSP than at high latitude (Cluster. On the nightside in the tail, a first wave event comparison - in a rather quiet time interval

  14. Biogeochemical linkage between atmosphere and ocean in the eastern equatorial Pacific Ocean: Results from the EqPOS research cruise

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    Furutani, H.; Inai, Y.; Aoki, S.; Honda, H.; Omori, Y.; Tanimoto, H.; Iwata, T.; Ueda, S.; Miura, K.; Uematsu, M.

    2012-12-01

    Eastern equatorial Pacific Ocean is a unique oceanic region from several biogeochemical points of view. It is a remote open ocean with relatively high marine biological activity, which would result in limited influence of human activity but enhanced effect of marine natural processes on atmospheric composition. It is also characterized as high nutrient low chlorophyll (HNLC) ocean, in which availability of trace metals such as iron and zinc limits marine primary production and thus atmospheric deposition of these trace elements to the ocean surface is expected to play an important role in regulating marine primary production and defining unique microbial community. High sea surface temperature in the region generates strong vertical air convection which efficiently brings tropospheric atmospheric composition into stratosphere. In this unique eastern equatorial Pacific Ocean, EqPOS (Equatorial Pacific Ocean and Stratospheric/Tropospheric Atmospheric Study) research cruise was organized as a part of SOLAS Japan activity to understand biogeochemical ocean-atmospheric interaction in the region. Coordinated atmospheric, oceanic, and marine biological observations including sampling/characterization of thin air-sea interfacial layer (sea surface microlayer: SML) and launching large stratospheric air sampling balloons were carried out on-board R/V Hakuho Maru starting from 29 January for 39 days. Biogeochemically important trace/long-lived gases such as CO2, dimethyl sulfide (DMS), and some volatile organic carbons (VOCs) both in the atmosphere and seawater were continuously monitored and their air-sea fluxes were also observed using gradient and eddy-covariance techniques. Atmospheric gas measurement of CO2, CH4, N2O, SF6, CO, H2, Ar and isotopic composition of selected gases were further extended to stratospheric air by balloon-born sampling in addition to a vertical profiling of O3, CO2, and H2O with sounding sondes. Physical and chemical properties of marine

  15. New Magnetic and 10Be/9Be results from ODP site 851 (East Equatorial Pacific)

    Science.gov (United States)

    Valet, J. P.; Savranskaia, T.; Anojh, T.; Meynadier, L.; Thouveny, N.; Gacem, L.; L2NC, A. T.; Bassinot, F. C.; Simon, Q.

    2017-12-01

    The paleomagnetic record from ODP site 851 was the first long data of relative paleointensity that attempted to describe 4 Ma of geomagnetic variations. Among other features, it was characterized by an asymmetrical saw-tooth pattern of the intensity changes across reversals. The upper part of the record (0 to 1.1 Ma) was documented by stepwise alternating field (af) demagnetization of U-channels, while the deeper part could not be sampled by U-channels and instead combined shipboard measurements and stepwise demagnetized single samples within specific intervals. Thermal demagnetization was also conducted within specific intervals to assess the absence of viscous component. We performed a new detailed study using U-channels and single samples that were taken along a continuous splice section that covers the upper 80 meters of sediment. Stepwise demagnetization of the natural magnetization and of the anhysteretic magnetization were carried out for all samples and U-channels in order to improve the resolution and the reliability of relative paleointensity for the older part of the record. The new results improve the detailed magnetostratigraphy that was formerly established and provide additional details to the paleointensity results. In parallel, 10Be/9Be measurements were carried out at the same levels as the magnetic measurements to test further the controversial asymmetrical pattern of relative paleointensity. Unfortunately, the 10Be/9Be results did not provide any consistent signal. This failure most likely results from high carbonate concentration (about 85%) that yields poor adsorption of beryllium by the sediment particles and therefore generates large fluctuations. The reliability of the paleointensity record is linked to downcore homogeneity of the sediment that is characterized by little variability of carbonate content and therefore little changes in the magnetization response to the field. Summarizing poor clay content appears to be a favorable situation

  16. Intravaginal cytomegalovirus (CMV challenge elicits maternal viremia and results in congenital transmission in a guinea pig model

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    Schleiss Mark R

    2011-03-01

    Full Text Available Abstract Background The objective of this study was to compare intravaginal (ivg and subcutaneous (sc administration of the guinea pig cytomegalovirus (GPCMV in pregnant and non-pregnant guinea pigs. These studies tested the hypotheses that ivg infection would elicit immune responses, produce maternal viremia, and lead to vertical transmission, with an efficiency similar to the traditionally employed sc route. Results Four groups of age- and size-matched guinea pigs were studied. Two groups were pregnant, and two groups were not pregnant. Animals received 5x105 plaque-forming units (PFU of a GPCMV reconstituted from an infectious bacterial artificial chromosome (BAC construct containing the full-length GPCMV genome. Seroconversion was compared by IgG ELISA, and viremia (DNAemia was monitored by PCR. In both pregnant and non-pregnant animals, sc inoculation resulted in significantly higher serum ELISA titers than ivg inoculation at 8 and 12 weeks post-infection. Patterns of viremia (DNAemia were similar in animals inoculated by either sc or ivg route. However, in pregnant guinea pigs, animals inoculated by both routes experienced an earlier onset of DNAemia than did non-pregnant animals. Neither the percentage of dead pups nor the percentage of GPCMV positive placentas differed by inoculation route. Conclusions In the guinea pig model of congenital CMV infection, the ivg route is as efficient at causing congenital infection as the conventional but non-physiologic sc route. This finding could facilitate future experimental evaluation of vaccines and antiviral interventions in this highly relevant animal model.

  17. [Analysis of uterus cervical cancer screening campaign results in Conakry, Guinea].

    Science.gov (United States)

    Leno, Daniel William Athanase; Diallo, Fatoumata Diaraye; Camara, Ansoumane Yassima; Magassouba, Mamadou; Komano, Faya Dendo; Traore, Ayelama; Niamy, Delphine; Tolno, Julien; Cissoko, Oumou; Bangoura, Mbalia; Keita, Namory

    2017-11-01

    Reduce morbidity and death rates of women with cervical cancer in Guinea. This was a five-day cross-sectional study carried out in two successive years (2012 and 2013) at the CERFFO-PCG in Conakry. The target population was women aged 25-49. Approximately 500 women for 2012 and 900 women were expected in these cervical screening campaigns by visual methods (IVA and IVL) with immediate treatment of precancerous lesions. After histologic confirmation of the cancer lesions, the management was carried out according to the protocols in force in the country. We performed a simple descriptive analysis and the results expressed as a percentage and on average. The target population represented 60.4% in 2012 and 76.2% in 2013, of the total number of women received. The incidence rate of high-grade intraepithelial lesions and cancers increased from 2.6% in 2012 to 0.9% in 2013. In 2012, the 57 precancerous lesions were treated with immediate treatment and 10 cases of cancers out of the 16 had a surgical treatment. Also in 2013, all precancerous lesions were treated immediately and 2 cancers out of the 4 benefited from surgery. Our research shows that, with creativity, flexibility, good organization and efficient use of resources, morbidity and death rates of women with cervical cancer in a very resources can be significantly reduced. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  18. The HIA instrument on board the Tan Ce 1 Double Star near-equatorial spacecraft and its first results

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    H. Rème

    2005-11-01

    Full Text Available On 29 December 2003, the Chinese spacecraft Tan Ce 1 (TC-1, the first component of the Double Star mission, was successfully launched within a low-latitude eccentric orbit. In the framework of the scientific cooperation between the Academy of Sciences of China and ESA, several European instruments, identical to those developed for the Cluster spacecraft, were installed on board this spacecraft. The HIA (Hot Ion Analyzer instrument on board the TC-1 spacecraft is an ion spectrometer nearly identical to the HIA sensor of the CIS instrument on board the 4 Cluster spacecraft. This instrument has been specially adapted for TC-1. It measures the 3-D distribution functions of the ions between 5 eV/q and 32 keV/q without mass discrimination. TC-1 is like a fifth Cluster spacecraft to study the interaction of the solar wind with the magnetosphere and to study geomagnetic storms and magnetospheric substorms in the near equatorial plane. HIA was commissioned in February 2004. Due to the 2 RE higher apogee than expected, some in-flight improvements were needed in order to use HIA in the solar wind in the initial phase of the mission. Since this period HIA has obtained very good measurements in the solar wind, the magnetosheath, the dayside and nightside plasma sheet, the ring current and the radiation belts. We present here the first results in the different regions of the magnetosphere and in the solar wind. Some of them are very new and include, for example, ion dispersion structures in the bow shock and ion beams close to the magnetopause. The huge interest in the orbit of TC-1 is strongly demonstrated.

  19. The HIA instrument on board the Tan Ce 1 Double Star near-equatorial spacecraft and its first results

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    H. Rème

    2005-11-01

    Full Text Available On 29 December 2003, the Chinese spacecraft Tan Ce 1 (TC-1, the first component of the Double Star mission, was successfully launched within a low-latitude eccentric orbit. In the framework of the scientific cooperation between the Academy of Sciences of China and ESA, several European instruments, identical to those developed for the Cluster spacecraft, were installed on board this spacecraft.

    The HIA (Hot Ion Analyzer instrument on board the TC-1 spacecraft is an ion spectrometer nearly identical to the HIA sensor of the CIS instrument on board the 4 Cluster spacecraft. This instrument has been specially adapted for TC-1. It measures the 3-D distribution functions of the ions between 5 eV/q and 32 keV/q without mass discrimination.

    TC-1 is like a fifth Cluster spacecraft to study the interaction of the solar wind with the magnetosphere and to study geomagnetic storms and magnetospheric substorms in the near equatorial plane.

    HIA was commissioned in February 2004. Due to the 2 RE higher apogee than expected, some in-flight improvements were needed in order to use HIA in the solar wind in the initial phase of the mission. Since this period HIA has obtained very good measurements in the solar wind, the magnetosheath, the dayside and nightside plasma sheet, the ring current and the radiation belts. We present here the first results in the different regions of the magnetosphere and in the solar wind. Some of them are very new and include, for example, ion dispersion structures in the bow shock and ion beams close to the magnetopause. The huge interest in the orbit of TC-1 is strongly demonstrated.

  20. Guinea pig maximization tests with formaldehyde releasers. Results from two laboratories

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Boman, A; Hamann, K

    1984-01-01

    The guinea pig maximization test was used to evaluate the sensitizing potential of formaldehyde and 6 formaldehyde releasers (Forcide 78, Germall 115, Grotan BK, Grotan OX, KM 200 and Preventol D2). The tests were carried out in 2 laboratories (Copenhagen and Stockholm), and although we intended...... the procedures to be the same, discrepancies were observed, possibly due to the use of different animal strains, test concentrations and vehicles. The sensitizing potential was in general found to be stronger in Stockholm compared to Copenhagen: formaldehyde sensitized 50% of the guinea pigs in Copenhagen and 95...

  1. Current meter components and other data from FIXED PLATFORMS from Gulf of Guinea and other locations as part of the Equatorial Pacific Ocean Climate Studies (EPOCS) and other projects from 08 July 1976 to 01 April 1982 (NODC Accession 9000067)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current meter components data were collected from FIXED PLATFORMS in the Gulf of Guinea and other locations from 08 July 1976 to 01 April 1982. Data were collected...

  2. Equatorial thermospheric winds: New results using data from a network of three Fabry-Perot interferometers located in central Peru

    Science.gov (United States)

    Meriwether, J. W.; Dominquez, L. N.; Milla, M. A.; Chau, J. L.; Makela, J. J.; Fisher, D.

    2013-12-01

    A new observing strategy aimed at improving our understanding of the properties of the equatorial thermosphere wind field, such as the vorticity and divergence, has been developed to generate maps of the thermospheric wind field. Estimates of the neutral wind are obtained from measurements of the Doppler shift of the thermospheric 630.0-nm emission obtained from a sequence of eight evenly spaced azimuthal directions for each of the three Fabry-Perot interferometer (FPI) observatories located in central Peru (Jicamarca, Nazca, and Arequipa). Measurements towards the zenith and a frequency-stabilized laser reference are also included in each sequence, which takes ~25 minutes to complete. Six of the off-zenith observing directions from the Nazca FPI observatory are used to make common volume (CV) measurements, where two of the FPIs observe the same thermospheric volume with a centroid height of ~250 km at orthogonal angles. These CV positions are located ~225 km north and south of the Nazca FPI observatory. The data obtained during a coordinated observation of the two FPIs observing the same CV location are used to compute estimates of the zonal (u) and meridional (v) wind components. The set of Doppler shifts measured by the three FPIs during a single sequence is used to produce a map of the neutral wind field for that period of time. The construction of this map is based upon the use of a first-order polynomial expansion of the neutral wind field relative to the site coordinates of each FPI location. This expansion includes the first-order gradients of u and v with respect to the zonal (x) and meridional (y) directions. Computation of the best fit in a linear least squares sense of the model expansion parameters to the Doppler shift data for all three sites determines the values of these gradient parameters. Results obtained for mid-winter 2013 show the anti-cyclonic circulation expected near the terminator generated by the day-to-night pressure gradient. Sequences

  3. Prevalence and Correlates of HIV Infection Among Sex Workers in Papua New Guinea: First Results from the Papua New Guinea and Australia Sexual Health Improvement Project (PASHIP).

    Science.gov (United States)

    Wand, Handan; Siba, Peter

    2015-12-01

    The primary objective of this study was to estimate the individual and combined impacts of socio-demographic and sexual behaviours on HIV diagnosis among 523 female sex workers who participated in the Papua New Guinea and Australia Sexual Health Improvement Project. Logistic regression models were used to identify the factors associated with HIV positivity. We estimated their population level impacts in order to quantify the proportion of HIV seropositivity is attributed to these factors. Less than 40 % of women consented to get tested for HIV. HIV prevalence was 7 % (95 % CI 4-11 %); lack of education and knowledge/awareness of HIV accounted for ~70 % of the HIV diagnoses. A major obstacle is lack of interest for testing. Our study underscored the major challenges in this culturally, linguistically heterogeneous country. The epidemic in Papua New Guinea requires targeted prevention interventions among those at highest risk of acquiring or transmitting infection.

  4. Vertical structure and characteristics of 23-60 day (zonal) oscillations over the tropical latitudes during the winter months of 1986 - Results of equatorial wave campaign-II

    Science.gov (United States)

    Raghavarao, R.; Suhasini, R.; Sridharan, R.; Krishnamurthy, B. V.; Nagpal, O. P.

    1990-01-01

    Results are presented of the equatorial wave campaign-II, a meteorological rocket study which was part of the Indian Middle Atmosphere Program. The equatorial wave campaign-II was conducted from Shar, India (13.7 deg N, 80.2 deg E) from January 15-February 28, 1986. By means of high altitude balloon and the RH-200 meteorological rocket, winds were measured from ground level up to 60 km altitude once each day during the 45-day period. The oscillation frequencies of the deviations in the east-west component of the winds from their mean at each 1-km height interval are obtained by the maximum entropy method. The phases and amplitudes of these frequencies are determined by use of the least squares method on the wind variation time series. Enhanced wave activity is shown to take place in the troposphere and lower mesosphere. The tropospheric waves observed suggest themselves to be Rossby waves of extratropical origin penetrating to tropical latitudes. The observed stratospheric/mesospheric waves appear to emanate from a source around the stratopause.

  5. Biodegradable soy wound dressings with controlled release of antibiotics: Results from a guinea pig burn model.

    Science.gov (United States)

    Egozi, Dana; Baranes-Zeevi, Maya; Ullmann, Yehuda; Gilhar, Amos; Keren, Aviad; Matanes, Elias; Berdicevsky, Israela; Krivoy, Norberto; Zilberman, Meital

    2015-11-01

    There is growing interest in the development of biodegradable materials from renewable biopolymers, such as soy protein, for biomedical applications. Soy protein is a major fraction of natural soybean and has the advantages of being economically competitive, biodegradable and biocompatible. It presents good water resistance as well as storage stability. In the current study, homogenous antibiotic-loaded soy protein films were cast from aqueous solutions. The antibiotic drug gentamicin was incorporated into the films in order to inhibit bacterial growth, and thus prevent or combat infection, upon its controlled release to the surrounding tissue. The current in vivo study of the dressing material in contaminated deep second-degree burn wounds in guinea pigs (n=20) demonstrated its ability to accelerate epithelialization with 71% epithelial coverage compared to an unloaded format of the soy material (62%) and a significant improved epithelial coverage as compared to the conventional dressing material (55%). Our new platform of antibiotic-eluting wound dressings is advantageous over currently used popular dressing materials that provide controlled release of silver ions, due to its gentamicin release profile, which is safer. Another advantage of our novel concept is that it is based on a biodegradable natural polymer and therefore does not require bandage changes and offers a potentially valuable and economic approach for treating burn-related infections. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

  6. The female guinea pig, a useful model for the genetic hazard of radiation in man; preliminary results on germ cell radiosensitivity in foetal, neonatal and adult animals

    International Nuclear Information System (INIS)

    Jacquet, P.; Vankerkom, J.; Lambiet-Collier, M.

    1994-01-01

    A comparison was made of the radiosensitivities of the resting oocyte of guinea pig in its two different states, the 'large' resting and 'contracted' oocyte, also extending the investigations to the radiosensitivity of the female germ cells at earlier stages during intrauterine life. Irradiation induced a dose-dependent decrease in the total number of oocytes, and this effect was more pronounced in animals irradiated as adults (target cells: contracted resting oocytes). Our results also suggested that the LD 50 of the large guinea pig resting oocyte should be around 4 Gy, a value similar to that obtained recently for the equivalent human oocyte. This confirms the high radioresistance of the guinea pig oocyte and the consequent suitability of this species for further detailed studies in relation to genetic hazards in man. (author)

  7. Factors affecting attendance at and timing of formal antenatal care: results from a qualitative study in Madang, Papua New Guinea.

    Directory of Open Access Journals (Sweden)

    Erin V W Andrew

    Full Text Available BACKGROUND: Appropriate antenatal care (ANC is key for the health of mother and child. However, in Papua New Guinea (PNG, only a third of women receive any ANC during pregnancy. Drawing on qualitative research, this paper explores the influences on ANC attendance and timing of first visit in the Madang region of Papua New Guinea. METHODS: Data were collected in three sites utilizing several qualitative methods: free-listing and sorting of terms and definitions, focus group discussions, in-depth interviews, observation in health care facilities and case studies of pregnant women. Respondents included pregnant women, their relatives, biomedical and traditional health providers, opinion leaders and community members. RESULTS: Although generally reported to be important, respondents' understanding of the procedures involved in ANC was limited. Factors influencing attendance fell into three main categories: accessibility, attitudes to ANC, and interpersonal issues. Although women saw accessibility (distance and cost as a barrier, those who lived close to health facilities and could easily afford ANC also demonstrated poor attendance. Attitudes were shaped by previous experiences of ANC, such as waiting times, quality of care, and perceptions of preventative care and medical interventions during pregnancy. Interpersonal factors included relationships with healthcare providers, pregnancy disclosure, and family conflict. A desire to avoid repeat clinic visits, ideas about the strength of the fetus and parity were particularly relevant to the timing of first ANC visit. CONCLUSIONS: This long-term in-depth study (the first of its kind in Madang, PNG shows how socio-cultural and economic factors influence ANC attendance. These factors must be addressed to encourage timely ANC visits: interventions could focus on ANC delivery in health facilities, for example, by addressing healthcare staff's attitudes towards pregnant women.

  8. Depressive symptoms among survivors of Ebola virus disease in Conakry (Guinea): preliminary results of the PostEboGui cohort.

    Science.gov (United States)

    Keita, Mamady Mory; Taverne, Bernard; Sy Savané, Sékou; March, Laura; Doukoure, Morifodé; Sow, Mamadou Saliou; Touré, Abdoulaye; Etard, Jean François; Barry, Moumié; Delaporte, Eric

    2017-04-04

    The 2013-2016 West African Ebola outbreak infected 28,616 people and caused 11,310 deaths by 11 May 2016, across six countries. The outbreak has also resulted in the largest number of EVD survivors in history-over 17,000. Guinea was declared Ebola-free on 1 June 2016. Reports from the outbreak documented 3814 cases resulting in 2544 deaths and 1270 survivors. EVD survivors face various neuropsychological and psycho-affective alterations that have not been fully identified yet. This study aims to document the depressive symptoms among adult survivors in Guinea. Depressive symptoms were investigated using the French version of the Center for Epidemiologic Studies-Depression Scale (CES-D) administered to all adult survivors (≥ 20 years) participating in the PostEboGui study and receiving care in Conakry. The study was combined with a clinical consultation by a psychiatrist at the Donka National Hospital in Conakry that ensured adapted care was provided when needed. Overall, 256 adult participants receiving care in Conakry participated in this study: 55% were women, median age 31 years [IQR: 26-40]. The median time since the Ebola Treatment Center (ETC) discharge was 8.1 months [IQR: 4.1-11.7]. 15% had a score above the threshold values indicating psychological suffering (15% for men and 14% for women). 33 people (16 women and 17 men) met with the psychiatrist, which resulted in the diagnosis of 3 cases of post-traumatic stress disorder (PTSD), 3 cases of mild depression, 13 cases of moderate depression, and 11 cases of severe depression, including 1 with kinesthetic hallucinations and another with visual hallucinations, and 1 with suicidal ideation and 3 with attempted suicide. Severe depression was diagnosed between 1 and 19 months after ETC discharge. The various identified forms of depression responded favorably to conventional drug therapies and cognitive behavioral therapy. Long-term follow-up for EVD survivors will be necessary to understand the evolution

  9. Intermonsoonal equatorial jets

    Digital Repository Service at National Institute of Oceanography (India)

    Muraleedharan, P.M.

    , respectively. Hydrographic features and transport computations favour a well developed equatorial jet during both seasons. The net surface eastward and subsurface westward flows are well balanced during the premonsoon transition period and appear...

  10. EQUATORIAL SUPERROTATION ON TIDALLY LOCKED EXOPLANETS

    International Nuclear Information System (INIS)

    Showman, Adam P.; Polvani, Lorenzo M.

    2011-01-01

    The increasing richness of exoplanet observations has motivated a variety of three-dimensional (3D) atmospheric circulation models of these planets. Under strongly irradiated conditions, models of tidally locked, short-period planets (both hot Jupiters and terrestrial planets) tend to exhibit a circulation dominated by a fast eastward, or 'superrotating', jet stream at the equator. When the radiative and advection timescales are comparable, this phenomenon can cause the hottest regions to be displaced eastward from the substellar point by tens of degrees longitude. Such an offset has been subsequently observed on HD 189733b, supporting the possibility of equatorial jets on short-period exoplanets. Despite its relevance, however, the dynamical mechanisms responsible for generating the equatorial superrotation in such models have not been identified. Here, we show that the equatorial jet results from the interaction of the mean flow with standing Rossby waves induced by the day-night thermal forcing. The strong longitudinal variations in radiative heating-namely intense dayside heating and nightside cooling-trigger the formation of standing, planetary-scale equatorial Rossby and Kelvin waves. The Rossby waves develop phase tilts that pump eastward momentum from high latitudes to the equator, thereby inducing equatorial superrotation. We present an analytic theory demonstrating this mechanism and explore its properties in a hierarchy of one-layer (shallow-water) calculations and fully 3D models. The wave-mean-flow interaction produces an equatorial jet whose latitudinal width is comparable to that of the Rossby waves, namely the equatorial Rossby deformation radius modified by radiative and frictional effects. For conditions typical of synchronously rotating hot Jupiters, this length is comparable to a planetary radius, explaining the broad scale of the equatorial jet obtained in most hot-Jupiter models. Our theory illuminates the dependence of the equatorial jet

  11. Factors affecting attendance at and timing of formal antenatal care: Results from a qualitative study in Madang, Papua New Guinea

    NARCIS (Netherlands)

    Andrew, E.V.W.; Pell, C.; Angwin, A.; Auwun, A.; Daniels, J.; Mueller, I.; Phuanukoonnon, S.; Pool, R.

    2014-01-01

    Background: Appropriate antenatal care (ANC) is key for the health of mother and child. However, in Papua New Guinea (PNG), only a third of women receive any ANC during pregnancy. Drawing on qualitative research, this paper explores the influences on ANC attendance and timing of first visit in the

  12. Knowledge, Attitudes, and Practices Concerning Malaria in Pregnancy: Results from a Qualitative Study in Madang, Papua New Guinea

    OpenAIRE

    Andrew, E.V.W.; Pell, C.; Angwin, A.; Auwun, A.; Daniels, J.; Mueller, I.; Phuanukoonnon, S.; Pool, R.

    2015-01-01

    BACKGROUND: Malaria is the leading cause of illness and death in Papua New Guinea (PNG). Infection during pregnancy with falciparum or vivax malaria, as occurs in PNG, has health implications for mother and child, causing complications such as maternal anemia, low birth weight and miscarriage. This article explores knowledge, attitudes and practices concerning malaria during pregn...

  13. Knowledge, Attitudes, and Practices Concerning Malaria in Pregnancy: Results from a Qualitative Study in Madang, Papua New Guinea

    NARCIS (Netherlands)

    Andrew, E.V.W.; Pell, C.; Angwin, A.; Auwun, A.; Daniels, J.; Mueller, I.; Phuanukoonnon, S.; Pool, R.

    2015-01-01

    Background Malaria is the leading cause of illness and death in Papua New Guinea (PNG). Infection during pregnancy with falciparum or vivax malaria, as occurs in PNG, has health implications for mother and child, causing complications such as maternal anemia, low birth weight and miscarriage. This

  14. Knowledge, attitudes, and practices concerning malaria in pregnancy: results from a qualitative study in Madang, Papua New Guinea.

    Science.gov (United States)

    Andrew, Erin V W; Pell, Christopher; Angwin, Angeline; Auwun, Alma; Daniels, Job; Mueller, Ivo; Phuanukoonnon, Suparat; Pool, Robert

    2015-01-01

    Malaria is the leading cause of illness and death in Papua New Guinea (PNG). Infection during pregnancy with falciparum or vivax malaria, as occurs in PNG, has health implications for mother and child, causing complications such as maternal anemia, low birth weight and miscarriage. This article explores knowledge, attitudes and practices concerning malaria during pregnancy and it's prevention in Madang, PNG, a high prevalence area. As part of a qualitative study in Madang, exploring MiP, participatory techniques (free-listing and sorting) were conducted along with focus group discussions, in-depth interviews (with pregnant women, health staff and other community members) and observations in the local community and health facilities. The main themes explored were attitudes towards and knowledge of MiP, its risks, and prevention. Although there was a general awareness of the term "malaria", it was often conflated with general sickness or with pregnancy-related symptoms. Moreover, many preventive methods for MiP were related to practices of general healthy living. Indeed, varied messages from health staff about the risks of MiP were observed. In addition to ideas about the seriousness and risk of MiP, other factors influenced the uptake of interventions: availability and perceived comfort of sleeping under insecticide-treated mosquito nets were important determinants of usage, and women's heavy workload influenced Chloroquine adherence. The non-specific symptoms of MiP and its resultant conflation with symptoms of pregnancy that are perceived as normal have implications for MiP prevention and control. However, in Madang, PNG, this was compounded by the inadequacy of health staff's message about MiP.

  15. Knowledge, attitudes, and practices concerning malaria in pregnancy: results from a qualitative study in Madang, Papua New Guinea.

    Directory of Open Access Journals (Sweden)

    Erin V W Andrew

    Full Text Available Malaria is the leading cause of illness and death in Papua New Guinea (PNG. Infection during pregnancy with falciparum or vivax malaria, as occurs in PNG, has health implications for mother and child, causing complications such as maternal anemia, low birth weight and miscarriage. This article explores knowledge, attitudes and practices concerning malaria during pregnancy and it's prevention in Madang, PNG, a high prevalence area.As part of a qualitative study in Madang, exploring MiP, participatory techniques (free-listing and sorting were conducted along with focus group discussions, in-depth interviews (with pregnant women, health staff and other community members and observations in the local community and health facilities.The main themes explored were attitudes towards and knowledge of MiP, its risks, and prevention. Although there was a general awareness of the term "malaria", it was often conflated with general sickness or with pregnancy-related symptoms. Moreover, many preventive methods for MiP were related to practices of general healthy living. Indeed, varied messages from health staff about the risks of MiP were observed. In addition to ideas about the seriousness and risk of MiP, other factors influenced the uptake of interventions: availability and perceived comfort of sleeping under insecticide-treated mosquito nets were important determinants of usage, and women's heavy workload influenced Chloroquine adherence.The non-specific symptoms of MiP and its resultant conflation with symptoms of pregnancy that are perceived as normal have implications for MiP prevention and control. However, in Madang, PNG, this was compounded by the inadequacy of health staff's message about MiP.

  16. Dracunculiasis (guinea worm disease).

    Science.gov (United States)

    Greenaway, Chris

    2004-02-17

    Dracunculiasis (guinea worm disease) is a parasitic disease that is limited to remote, rural villages in 13 sub-Saharan African countries that do not have access to safe drinking water. It is one the next diseases targeted for eradication by the World Health Organization. Guinea worm disease is transmitted by drinking water containing copepods (water fleas) that are infected with Dracunculiasis medinensis larvae. One year after human ingestion of infected water a female adult worm emerges, typically from a lower extremity, producing painful ulcers that can impair mobility for up to several weeks. This disease occurs annually when agricultural activities are at their peak. Large proportions of economically productive individuals of a village are usually affected simultaneously, resulting in decreased agricultural productivity and economic hardship. Eradication of guinea worm disease depends on prevention, as there is no effective treatment or vaccine. Since 1986, there has been a 98% reduction in guinea worm disease worldwide, achieved primarily through community-based programs. These programs have educated local populations on how to filter drinking water to remove the parasite and how to prevent those with ulcers from infecting drinking-water sources. Complete eradication will require sustained high-level political, financial and community support.

  17. Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results

    Directory of Open Access Journals (Sweden)

    L.C.M. Barboza Jr.

    2016-01-01

    Full Text Available In mammals, damage to sensory receptor cells (hair cells of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs are viable after transplantation into the basal turns of neomycin-injured guinea pig cochleas. We also examined the effects of mIESC transplantation on auditory functions. Eight adult female Cavia porcellus guinea pigs (250-350g were deafened by intratympanic neomycin delivery. After 7 days, the animals were randomly divided in two groups. The study group (n=4 received transplantation of LacZ-positive mIESCs in culture medium into the scala tympani. The control group (n=4 received culture medium only. At 2 weeks after transplantation, functional analyses were performed by auditory brainstem response measurement, and the animals were sacrificed. The presence of mIESCs was evaluated by immunohistochemistry of sections of the cochlea from the study group. Non-parametric tests were used for statistical analysis of the data. Intratympanic neomycin delivery damaged hair cells and increased auditory thresholds prior to cell transplantation. There were no significant differences between auditory brainstem thresholds before and after transplantation in individual guinea pigs. Some mIESCs were observed in all scalae of the basal turns of the injured cochleas, and a proportion of these cells expressed the hair cell marker myosin VIIa. Some transplanted mIESCs engrafted in the cochlear basilar membrane. Our study demonstrates that transplanted cells survived and engrafted in the organ of Corti after cochleostomy.

  18. Spatial and temporal variations of small-scale plasma turbulence parameters in the equatorial electrojet: HF and VHF radar observational results

    Directory of Open Access Journals (Sweden)

    G. Manju

    2005-06-01

    Full Text Available The spatial and temporal variations of various parameters associated with plasma wave turbulence in the equatorial electrojet (EEJ at the magnetic equatorial location of Trivandrum (8.5° N, 77° E; dip 0.5° N are studied for the first time, using co-located HF (18MHz and VHF (54.95MHz coherent backscatter radar observations (daytime in the altitude region of 95-110km, mostly on magnetically quiet days. The derived turbulence parameters are the mean electron density irregularity strength (δn/n, anomalous electron collision frequency (νe* and the corrected east-west electron drift velocity (Vey. The validity of the derived parameters is confirmed using radar data at two different frequencies and comparing with in-situ measurements. The behaviour of δn/n in relation to the backscattered power during weak and strong EEJ conditions is also examined to understand the growth and evolution of turbulence in the electrojet.

  19. Spatial and temporal variations of small-scale plasma turbulence parameters in the equatorial electrojet: HF and VHF radar observational results

    Directory of Open Access Journals (Sweden)

    G. Manju

    2005-06-01

    Full Text Available The spatial and temporal variations of various parameters associated with plasma wave turbulence in the equatorial electrojet (EEJ at the magnetic equatorial location of Trivandrum (8.5° N, 77° E; dip 0.5° N are studied for the first time, using co-located HF (18MHz and VHF (54.95MHz coherent backscatter radar observations (daytime in the altitude region of 95-110km, mostly on magnetically quiet days. The derived turbulence parameters are the mean electron density irregularity strength (δn/n, anomalous electron collision frequency (νe* and the corrected east-west electron drift velocity (Vey. The validity of the derived parameters is confirmed using radar data at two different frequencies and comparing with in-situ measurements. The behaviour of δn/n in relation to the backscattered power during weak and strong EEJ conditions is also examined to understand the growth and evolution of turbulence in the electrojet.

  20. Pacific Equatorial Transect

    OpenAIRE

    Pälike, Heiko; Nishi, Hiroshi; Lyle, Mitch; Raffi, Isabella; Klaus, Adam; Gamage, Kusali

    2009-01-01

    Integrated Ocean Drilling Program Expedition 320/321, "Pacific Equatorial Age Transect" (Sites U1331–U1338), was designed to recover a continuous Cenozoic record of the paleoequatorial Pacific by coring above the paleoposition of the Equator at successive crustal ages on the Pacific plate. These sediments record the evolution of the paleoequatorial climate system throughout the Cenozoic. As we gained more information about the past movement of plates and when in Earth's history "critical" cli...

  1. Deep-sea environment and biodiversity of the West African Equatorial margin

    Science.gov (United States)

    Sibuet, Myriam; Vangriesheim, Annick

    2009-12-01

    The long-term BIOZAIRE multidisciplinary deep-sea environmental program on the West Equatorial African margin organized in partnership between Ifremer and TOTAL aimed at characterizing the benthic community structure in relation with physical and chemical processes in a region of oil and gas interest. The morphology of the deep Congo submarine channel and the sedimentological structures of the deep-sea fan were established during the geological ZAIANGO project and helped to select study sites ranging from 350 to 4800 m water depth inside or near the channel and away from its influence. Ifremer conducted eight deep-sea cruises on board research vessels between 2000 and 2005. Standardized methods of sampling together with new technologies such as the ROV Victor 6000 and its associated instrumentation were used to investigate this poorly known continental margin. In addition to the study of sedimentary environments more or less influenced by turbidity events, the discovery of one of the largest cold seeps near the Congo channel and deep coral reefs extends our knowledge of the different habitats of this margin. This paper presents the background, objectives and major results of the BIOZAIRE Program. It highlights the work achieved in the 16 papers in this special issue. This synthesis paper describes the knowledge acquired at a regional and local scale of the Equatorial East Atlantic margin, and tackles new interdisciplinary questions to be answered in the various domains of physics, chemistry, taxonomy and ecology to better understand the deep-sea environment in the Gulf of Guinea.

  2. Papua New Guinea.

    Science.gov (United States)

    1986-10-01

    The situation of the island archipelago nation of Papua New Guinea is reviewed in terms of its geography, people, history, government, politics economy and foreign relations. Papua New Guinea consists of the eastern half of the main island of New Guinea (the western portion is Indonesia), and several island groups, all located northeast of Australia. The island has extreme geographical variations, ranging from precipitous mountains to extensive swamps and river valleys, all in a monsoon cimate. As a result, there are hundreds of small groups each with unique cultures and languages; over 650 languages, many unrelated to each other. The population is estimated at 3.5 million, growing at about 2.5% per year. Historically, the region has been occupied by Germany, Britain, Japan, and the U.S. The country came under the international trusteeship system in 1949, and now has a vigorous parliamentary government. The economy is based on subsistence agriculture, but is buttressed by resources such as gold, copper, and other metals, oil, timber, tropical agricultural products, fish. The only indusry is local production, since the minimum wage is too high to compete with Asian labor.

  3. A new species of Rhododendron from New Guinea (Ericaceae)

    NARCIS (Netherlands)

    Kores, Paul

    1978-01-01

    The Star Mountains of New Guinea are situated at the geographic center of the Island of New Guinea extending on both sides of the Indonesian-Papua New Guinea border. Access to these mountains from either side of the border which divides the island is relatively difficult and as a result few

  4. The Burden of Drug-Resistant Tuberculosis in Papua New Guinea: Results of a Large Population-Based Survey.

    Directory of Open Access Journals (Sweden)

    Paul Aia

    Full Text Available Reliable estimates of the burden of multidrug-resistant tuberculosis (MDR-TB are crucial for effective control and prevention of tuberculosis (TB. Papua New Guinea (PNG is a high TB burden country with limited information on the magnitude of the MDR-TB problem.A cross-sectional study was conducted in four PNG provinces: Madang, Morobe, National Capital District and Western Province. Patient sputum samples were tested for rifampicin resistance by the Xpert MTB/RIF assay and those showing the presence of resistance underwent phenotypic susceptibility testing to first- and second-line anti-TB drugs including streptomycin, isoniazid, rifampicin, ethambutol, pyrazinamide, ofloxacin, amikacin, kanamycin and capreomycin.Among 1,182 TB patients enrolled in the study, MDR-TB was detected in 20 new (2.7%; 95% confidence intervals [CI] 1.1-4.3% and 24 previously treated (19.1%; 95%CI: 8.5-29.8% TB cases. No case of extensively drug-resistant TB (XDR-TB was detected. Thirty percent (6/20 of new and 33.3% (8/24 of previously treated cases with MDR-TB were detected in a single cluster in Western Province.In PNG the proportion of MDR-TB in new cases is slightly lower than the regional average of 4.4% (95%CI: 2.6-6.3%. A large proportion of MDR-TB cases were identified from a single hospital in Western Province, suggesting that the prevalence of MDR-TB across the country is heterogeneous. Future surveys should further explore this finding. The survey also helped strengthening the use of smear microscopy and Xpert MTB/RIF testing as diagnostic tools for TB in the country.

  5. An initial examination of carbonate production in the western equatorial Pacific: XRF results from the Pliocene-Pleistocene of IODP Site U1490

    Science.gov (United States)

    Chapman, J.; Kulhanek, D. K.; Rosenthal, Y.; Holbourn, A. E.

    2017-12-01

    International Ocean Discovery Program (IODP) Expedition 363 sought to determine the nature of and driving forces behind climate variability in the Western Pacific Warm Pool (WPWP) region throughout the Neogene on millennial, orbital, and geologic timescales. Our research focuses on the Pliocene to recent (4-0 Ma) sediment record from IODP Site U1490 to examine changes in carbonate production and burial in the WPWP as a record of variations in the regional/global carbon cycle. This interval is of particular interest because it spans the Middle Pliocene Warm Period, the initiation of Northern Hemisphere Glaciation, and the Mid-Pleistocene Transition. Site U1490 is located on the northern edge of Eauripik Rise at 05°58.95'N, 142°39.27'E in the northern part of the WPWP. At 2341 m water depth, today the site is bathed in Upper Circumpolar Deepwater. Pliocene to recent sediment primarily consists of foraminifer-rich nannofossil ooze, with the sedimentation rate varying between 1.5 and 3 cm/kyr. Initial shipboard measurement of calcium carbonate content shows little variation at low resolution (1 sample every few meters), varying between 90 and 95 wt%. We collected X-ray fluorescence (XRF) data at 2 cm resolution along the composite stratigraphic section to obtain a qualitative measure of the bulk chemistry of the sediment. We will use the weight percent calcium carbonate of discrete samples to calibrate the XRF data to generate a high-resolution carbonate record. We observe cyclical variations in the Ca/Ba, which may reflect variations in productivity and/or dissolution through this interval, although additional work is needed to fully interpret these data. Ultimately our research will allow for comparison between records obtained from these cores located in the western equatorial Pacific to those obtained in the eastern and central Pacific, which will better elucidate the nature of the carbon system during the Plio-Pleistocene.

  6. An initial examination of carbonate variability in the western equatorial Pacific: XRF results from the lower to middle Miocene of IODP Site U1490

    Science.gov (United States)

    Valerio, D. A.; Kulhanek, D. K.; Rosenthal, Y.; Holbourn, A. E.

    2017-12-01

    International Ocean Discovery Program (IODP) Expedition 363 sought to determine the nature of and driving forces behind climate variability in the Western Pacific Warm Pool (WPWP) region throughout the Neogene on millennial, orbital, and geologic timescales. Our research focuses on the Miocene (19-9 Ma) sediment record from IODP Site U1490 to examine changes in carbonate production and burial in the WPWP as a record of variations in the regional/global carbon cycle. This interval is of particular interest because it spans the Middle Miocene Climatic Optimum, the Middle Miocene Climate Transition, and the late Miocene carbonate crash. Site U1490 is located on the northern edge of Eauripik Rise at 05°58.95'N, 142°39.27'E in the northern part of the WPWP. At 2341 m water depth, today the site is bathed in Upper Circumpolar Deepwater. Miocene sediment at Site U1490 primarily consists of clay-bearing to clay-rich foraminifer-rich nannofossil ooze, although biogenic silica (primarily radiolaria) is a significant component in the lowermost part of the record. The sedimentation rate in the early to middle Miocene was very low (calcium carbonate content of 87 wt% throughout the site, with the most significant variations in the lower to middle Miocene, where contents range from 20 to 85 wt%. We collected X-ray fluorescence (XRF) data at 1 cm resolution along the composite stratigraphic section over the 19-9 Ma interval to obtain a qualitative measure of the bulk chemistry of the sediment. We will use the weight percent calcium carbonate of discrete samples to calibrate the XRF data to generate a high-resolution carbonate record. We observe cyclical variations in the Ca/Ba, which may reflect variations in productivity and/or dissolution through this interval, although additional work is needed to fully interpret these data. Ultimately our research will allow for comparison between records obtained from these cores located in the western equatorial Pacific to those obtained

  7. Equatorial electrojet in east Brazil longitudes

    Indian Academy of Sciences (India)

    dip latitude as the electrons/ions can move vertically along the inclined magnetic field lines. Equatorial electrojet has been extensively studied from ground, rocket ... Keywords. Equatorial electrojet; Brazilian anomaly in equatorial electrojet; asymmetries in equatorial electrojet. J. Earth Syst. Sci. 119, No. 4, August 2010, pp.

  8. Proton flux under radiation belts: near-equatorial zone

    International Nuclear Information System (INIS)

    Grigoryan, O.R.; Panasyuk, M.I.; Petrov, A.N.; Kudela, K.

    2005-01-01

    In this work the features of low-energy proton flux increases in near-equatorial region (McIlvein parameter L th the proton flux (with energy from tens keV up to several MeV) increases are registering regularly. However modern proton flux models (for example AP8 model) works at L>1.15 only and does not take into account near-equatorial protons. These fluxes are not too big, but the investigation of this phenomenon is important in scope of atmosphere-ionosphere connections and mechanisms of particles transport in magnetosphere. In according to double charge-exchange model the proton flux in near-equatorial region does not depend on geomagnetic local time (MLT) and longitude. However the Azur satellite data and Kosmos-484, MIR station and Active satellite data revealed the proton flux dependence on longitude. The other feature of near-equatorial proton flux is the dependence on geomagnetic local time revealed in the Sampex satellite experiment and other experiments listed above. In this work the dependences on MLT and longitude are investigated using the Active satellite (30-500 keV) and Sampex satellite (>800 keV). This data confirms that main sources of near-equatorial protons are radiation belts and ring current. The other result is that near-equatorial protons are quasi-trapped. The empirical proton flux dependences on L, B at near-equatorial longitudes are presented. (author)

  9. [Spontaneous neoplasms in guinea pigs].

    Science.gov (United States)

    Khar'kovskaia, N A; Khrustalev, S A; Vasil'eva, N N

    1977-01-01

    The authors present an analysis of the data of foreign literature and the results of their personal studies of spontaneous neoplasms in 40 guinea pigs of national breeding observed during observed during a 5-year period. In 4 of them malignant tumors were diagnosed-lympholeucosis (2 cases), dermoid ovarian cysts and also cancer and adenoma of the adrenal cortex (in one animal). The neoplasms described developed in guinea pigs, aged over 4 years, and they are referred to as mostly common tumors in this species of animals.

  10. Equatorial westward electrojet impacting equatorial ionization anomaly development during the 6 April 2000 superstorm

    Science.gov (United States)

    Horvath, Ildiko; Lovell, Brian C.

    2013-11-01

    investigate the forward plasma fountain and the equatorial ionosphere in the topside region during the 6 April 2000 superstorm in the Australian sector at ~0900 LT. Space- and ground-based multi-instrument measurements, Coupled Thermosphere-Ionosphere-Plasmasphere Electrodynamics (CTIPe) simulations, and field-aligned observations comprise our results. These reveal an unusual storm development during which the eastward prompt penetration electric (E) field (PPEF) developed and operated under the continuous effects of the westward disturbance dynamo E-field (DDEF) while large-scale traveling ionospheric disturbances (TIDs) traveled equatorward and generated strong equatorward wind surges. We have identified the eastward PPEF by the superfountain effect causing the equatorial ionization anomaly (EIA)'s development with crests situated at ~±28°N (geomagnetic) in the topside ionosphere at ~840 km altitude. The westward DDEF's occurrence is confirmed by mapping the "anti-Sq" current system wherein the equatorial westward current created a weak long-lasting westward electrojet event. Line plots of vertical drift data tracked large-scale TIDs. Four scenarios, covering ~3.5 h in universal time, demonstrate that the westward DDEF became superimposed on the eastward PPEF. As these E-fields of different origins became mapped into the F region, they could interact. Consequently, the eastward PPEF-related equatorial upward E × B drift became locally reduced by up to 75 m/s near the dip equator by the westward DDEF-related equatorial downward E × B drift. Meanwhile, the EIA displayed a better development as equatorial wind surges, reproduced by CTIPe, increased from 501 to 629 m/s, demonstrating the crucial role of mechanical wind effects keeping plasma density high.

  11. Comparison of Human and Guinea Pig Acetylcholinesterase Sequences and Rates of Oxime-Assisted Reactivation

    Science.gov (United States)

    2010-01-01

    of appropriate animal model systems. For OP poisoning, the guinea pig (Cavia porcellus) is a commonly used animal model because guinea pigs more...endogenous bioscavenger in vivo. Although guinea pigs historically have been used to test OP poisoning therapies, it has been found recently that guinea pig AChE...transcribed mRNA encoding guinea pig AChE, amplified the resulting cDNA, and sequenced this product. The nucleotide and deduced amino acid sequences of

  12. The role of indigenous traditional counting systems in children's development of numerical cognition: results from a study in Papua New Guinea

    Science.gov (United States)

    Matang, Rex A. S.; Owens, Kay

    2014-09-01

    The Government of Papua New Guinea undertook a significant step in developing curriculum reform policy that promoted the use of Indigenous knowledge systems in teaching formal school subjects in any of the country's 800-plus Indigenous languages. The implementation of the Elementary Cultural Mathematics Syllabus is in line with the above curriculum emphasis. Given the aims of the reform, the research reported here investigated the influence of children's own mother tongue (Tok Ples) and traditional counting systems on their development of early number knowledge formally taught in schools. The study involved 272 school children from 22 elementary schools in four provinces. Each child participated in a task-based assessment interview focusing on eight task groups relating to early number knowledge. The results obtained indicate that, on average, children learning their traditional counting systems in their own language spent shorter time and made fewer mistakes in solving each task compared to those taught without Tok Ples (using English and/or the lingua franca, Tok Pisin). Possible reasons accounting for these differences are also discussed.

  13. Time dependent response of equatorial ionospheric electric fieldsto magnetospheric disturbances

    OpenAIRE

    Fejer, Bela G.; Scherliess, L.

    1995-01-01

    We use extensive radar measurements of F region vertical plasma drifts and auroral electrojet indices to determine the storm time dependence of equatorial zonal electric fields. These disturbance drifts result from the prompt penetration of high latitude electric fields and from the dynamo action of storm time winds which produce largest perturbations a few hours after the onset of magnetic activity. The signatures of the equatorial disturbance electric fields change significantly depending o...

  14. Comparative phylogeography in rainforest trees from Lower Guinea, Africa.

    Directory of Open Access Journals (Sweden)

    Myriam Heuertz

    Full Text Available Comparative phylogeography is an effective approach to assess the evolutionary history of biological communities. We used comparative phylogeography in fourteen tree taxa from Lower Guinea (Atlantic Equatorial Africa to test for congruence with two simple evolutionary scenarios based on physio-climatic features 1 the W-E environmental gradient and 2 the N-S seasonal inversion, which determine climatic and seasonality differences in the region. We sequenced the trnC-ycf6 plastid DNA region using a dual sampling strategy: fourteen taxa with small sample sizes (dataset 1, mean n = 16/taxon, to assess whether a strong general pattern of allele endemism and genetic differentiation emerged; and four taxonomically well-studied species with larger sample sizes (dataset 2, mean n = 109/species to detect the presence of particular shared phylogeographic patterns. When grouping the samples into two alternative sets of two populations, W and E, vs. N and S, neither dataset exhibited a strong pattern of allelic endemism, suggesting that none of the considered regions consistently harboured older populations. Differentiation in dataset 1 was similarly strong between W and E as between N and S, with 3-5 significant F ST tests out of 14 tests in each scenario. Coalescent simulations indicated that, given the power of the data, this result probably reflects idiosyncratic histories of the taxa, or a weak common differentiation pattern (possibly with population substructure undetectable across taxa in dataset 1. Dataset 2 identified a common genetic break separating the northern and southern populations of Greenwayodendron suaveolens subsp. suaveolens var. suaveolens, Milicia excelsa, Symphonia globulifera and Trichoscypha acuminata in Lower Guinea, in agreement with differentiation across the N-S seasonal inversion. Our work suggests that currently recognized tree taxa or suspected species complexes can contain strongly differentiated genetic lineages

  15. Performance evaluation of GPS receiver under equatorial scintillation

    Directory of Open Access Journals (Sweden)

    Alison de Oliveira Moraes

    2009-06-01

    Full Text Available Equatorial scintillation is a phenomenon that occurs daily in the equatorial region after the sunset and affects radio signals that propagate through the ionosphere. Depending on the temporal and spatial situation, equatorial scintillation can represent a problem in the availability and precision of the Global Positioning System (GPS. This work is concerned with evaluating the impact of equatorial scintillation on the performance of GPS receivers. First, the morphology and statistical model of equatorial scintillation is briefly presented. A numerical model that generates synthetic scintillation data to simulate the effects of equatorial scintillation is presented. An overview of the main theoretical principles on GPS receivers is presented. The analytical models that describe the effects of scintillation at receiver level are presented and compared with numerical simulations using a radio software receiver and synthetic data. The results achieved by simulation agreed quite well with those predicted by the analytical models. The only exception is for links with extreme levels of scintillation and when weak signals are received.

  16. PreliminaryEquatorial Paleomagnetic results from Mt Kenya lavas. Neil D Opdyke, 1, Dennis V Kent, 2, Kainian Huang ,1, J.P. Patel , 3

    Science.gov (United States)

    Opdyke, N. D.; Kent, D. V.; Huang, K.; Patel, J. P.

    2007-12-01

    Field work on this study was carried out in August of 2006 by field parties from the University of Florida and Rutgers University. Mt Kenya is believed to be Plio-Pleistocene in age and an Argon dating survey is underway Ten samples were taken at each site consisting of one exposure in individual lava Flows. These exposures are usually in road cuts, streambeds and in some cases roadbeds. We sampled 100 sites distributed around the Mt Kenya Massif and to the northeast along the Nyambini range. The equator bisex's Mt Kenya and all sites were sampled within 40" north or south of the equator . The samples were returned to the US and processed at the University of Florida paleomagnetic laboratory. Many sites were severely affected by lightning however after demagnetization 68 sites yielded directions with alpha 95's equal to or less than 10°. Normal magnetized sites dominate, with N=58 (Dec=1°,Inc -0.1°,α95=2.6°) whereas only 10 reverse sites(Dec. =181.9,Inc. .6°α 95=8°) were identified. The combined site mean direction is Dec=1.1°, Inc..= -0.2° and α 95=3.2°. This result is not significantly different from what is expected from the geocentric axial dipole. VGP's were calculated from each site and the dispersion is low with the ASD = 11° which is in agreement with model "G" of MacFadden and McElhinny .No transitional directions were identified . Quadrupole components are not resolved. 1 Department of geological Sciences, the University of Florida , 2 Dept of Geology, Rutgers University,3,dept of Physics ,The University of Nairobi

  17. Equatorial paleomagnetic time-averaged field results from 0-5 Ma lavas from Kenya and the latitudinal variation of angular dispersion

    Science.gov (United States)

    Opdyke, Neil D.; Kent, Dennis V.; Huang, Kainian; Foster, David A.; Patel, J. P.

    2010-05-01

    Lavas of Pliocene-Pleistocene age were sampled in two regions in Kenya: Mount Kenya on the equator and the Loiyangalani region, east of Lake Turkana, at about 3°N. We sampled 100 sites distributed around the Mount Kenya Massif and to the northeast along the Nyambini Range. The equator bisects Mount Kenya, and all sites were sampled within 40' of the equator. Thirty-two sites were sampled in the Loiyangalani area, making a total of 132 sites. Many sites from the Mount Kenya study were severely affected by lightning; however, after progressive AF demagnetization 69 sites yielded directions with α95 equal to or less than 10°. Normal polarity sites dominate (N = 58 and a mean of declination (dec) = 1.2°, inclination (inc) = -0.7°, and α95 = 3.6°) with only 11 reverse polarity sites (mean of dec = 182.3°, inc = 0.6°, and α95 = 7.2°); no transitional directions were identified. Inverting the reverse sites yields a combined mean direction of dec = l.4°, inc = -0.7°, and α95 = 3.2°. This result is not significantly different from what is expected from the geocentric axial dipole for the mean locality (dec = 0° and inc = 0°); a quadrupole component was not resolved. The samples from the Loiyangalani region were not seriously affected by lightning, and all 32 sites gave satisfactory data with α95 less than 10° (17 reverse sites, dec = 183.4°, inc = 0.8°, and α95 = 6.7°; 15 normal sites, dec = 358.6°, inc = -1.1°, and α95 = 4.7°); after inverting the reverse sites the combined mean was dec = 1.1°, inc = -1.0°, and α95 = 4.1°. Altogether, we had a total of 101 successful sites. A virtual geomagnetic pole (VGP) was calculated from each site mean; the VGP dispersion is low, with Sb = 10.9° for Mount Kenya and 9.8° for the Loiyangalani region. This dispersion agrees with updated Model G of McElhinny and McFadden (1997) and model TK03 of Tauxe and Kent (2004) that was tuned to the compilation of McElhinny and McFadden (1997) but disagrees with the

  18. The effect of Congo River freshwater discharge on Eastern Equatorial Atlantic climate variability

    Energy Technology Data Exchange (ETDEWEB)

    Materia, Stefano [Centro Euro-Mediterraneo per i Cambiamenti Climatici, Bologna (Italy); Gualdi, Silvio; Navarra, Antonio [Centro Euro-Mediterraneo per i Cambiamenti Climatici, Bologna (Italy); Istituto Nazionale di Geofisica e Vulcanologia, Bologna (Italy); Terray, Laurent [Sciences de l' Univers au CERFACS, URA1875 CERFACS/CNRS, Toulouse (France)

    2012-11-15

    The surface ocean explains a considerable part of the inter-annual Tropical Atlantic variability. The present work makes use of observational datasets to investigate the effect of freshwater flow on sea surface salinity (SSS) and temperature (SST) in the Gulf of Guinea. In particular, the Congo River discharges a huge amount of freshwater into the ocean, affecting SSS in the Eastern Equatorial Atlantic (EEA) and stratifying the surface layers. The hypothesis is that an excess of river runoff emphasize stratification, influencing the ocean temperature. In fact, our findings show that SSTs in the Gulf of Guinea are warmer in summers following an anomalously high Congo spring discharge. Vice versa, when the river discharges low freshwater, a cold anomaly appears in the Gulf. The response of SST is not linear: temperature anomalies are considerable and long-lasting in the event of large freshwater flow, while in dry years they are less remarkable, although still significant. An excess of freshwater seems able to form a barrier layer, which inhibits vertical mixing and the entrainment of the cold thermocline water into the surface. Other processes may contribute to SST variability, among which the net input of atmospheric freshwater falling over EEA. Likewise the case of continental runoff from Congo River, warm anomalies occur after anomalously rainy seasons and low temperatures follow dry seasons, confirming the effect of freshwater on SST. However, the two sources of freshwater anomaly are not in phase, so that it is possible to split between atypical SST following continental freshwater anomalies and rainfall anomalies. Also, variations in air-sea fluxes can produce heating and cooling of the Gulf of Guinea. Nevertheless, atypical SSTs cannot be ascribed to fluxes, since the temperature variation induced by them is not sufficient to explain the SST anomalies appearing in the Gulf after anomalous peak discharges. The interaction processes between river runoff, sea

  19. An equatorial coronal hole at solar minimum

    Science.gov (United States)

    Bromage, B. J. I.; DelZanna, G.; DeForest, C.; Thompson, B.; Clegg, J. R.

    1997-01-01

    The large transequatorial coronal hole that was observed in the solar corona at the end of August 1996 is presented. It consists of a north polar coronal hole called the 'elephant's trunk or tusk'. The observations of this coronal hole were carried out with the coronal diagnostic spectrometer onboard the Solar and Heliospheric Observatory (SOHO). The magnetic field associated with the equatorial coronal hole is strongly connected to that of the active region at its base, resulting in the two features rotating at almost the same rate.

  20. Space Weather Research in the Equatorial Region: A Philosophical Reinforcement

    Science.gov (United States)

    Chukwuma, Victor; Odunaike, Rasaki; Laoye, John

    Investigations using radio waves reflected from the ionosphere, at high-and mid-latitudes indicate that ionospheric absorption can strongly increase following geomagnetic storms; which appears to suggest some definite relationship between ionospheric radio wave absorption and geomagnetic storms at these latitudes. However, corresponding earlier studies in the equatorial region did not appear to show any explicit relationship between ionospheric radio wave absorption and geomagnetic storm activity. This position appeared acceptable to the existing scientific paradigm, until in an act of paradigm shift, by a change of storm selection criteria, some more recent space weather investigations in the low latitudes showed that ionospheric radio wave absorption in the equatorial region clearly increases after intense storms. Given that these results in the equatorial region stood against the earlier results, this paper presently attempts to highlight their philosophical underpinning and posit that they constitute a scientific statement.

  1. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial.

    Science.gov (United States)

    Henao-Restrepo, Ana Maria; Longini, Ira M; Egger, Matthias; Dean, Natalie E; Edmunds, W John; Camacho, Anton; Carroll, Miles W; Doumbia, Moussa; Draguez, Bertrand; Duraffour, Sophie; Enwere, Godwin; Grais, Rebecca; Gunther, Stephan; Hossmann, Stefanie; Kondé, Mandy Kader; Kone, Souleymane; Kuisma, Eeva; Levine, Myron M; Mandal, Sema; Norheim, Gunnstein; Riveros, Ximena; Soumah, Aboubacar; Trelle, Sven; Vicari, Andrea S; Watson, Conall H; Kéïta, Sakoba; Kieny, Marie Paule; Røttingen, John-Arne

    2015-08-29

    A recombinant, replication-competent vesicular stomatitis virus-based vaccine expressing a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola vaccine candidate. We report the results of an interim analysis of a trial of rVSV-ZEBOV in Guinea, west Africa. For this open-label, cluster-randomised ring vaccination trial, suspected cases of Ebola virus disease in Basse-Guinée (Guinea, west Africa) were independently ascertained by Ebola response teams as part of a national surveillance system. After laboratory confirmation of a new case, clusters of all contacts and contacts of contacts were defined and randomly allocated 1:1 to immediate vaccination or delayed (21 days later) vaccination with rVSV-ZEBOV (one dose of 2 × 10(7) plaque-forming units, administered intramuscularly in the deltoid muscle). Adults (age ≥18 years) who were not pregnant or breastfeeding were eligible for vaccination. Block randomisation was used, with randomly varying blocks, stratified by location (urban vs rural) and size of rings (≤20 vs >20 individuals). The study is open label and masking of participants and field teams to the time of vaccination is not possible, but Ebola response teams and laboratory workers were unaware of allocation to immediate or delayed vaccination. Taking into account the incubation period of the virus of about 10 days, the prespecified primary outcome was laboratory-confirmed Ebola virus disease with onset of symptoms at least 10 days after randomisation. The primary analysis was per protocol and compared the incidence of Ebola virus disease in eligible and vaccinated individuals in immediate vaccination clusters with the incidence in eligible individuals in delayed vaccination clusters. This trial is registered with the Pan African Clinical Trials Registry, number PACTR201503001057193. Between April 1, 2015, and July 20, 2015, 90 clusters, with a total population of 7651 people were included in the planned interim analysis. 48 of

  2. Guinea-Bissau.

    Science.gov (United States)

    1985-04-01

    This discussion of Guinea-Bissau focuses on the following: the people; geography; history; government and political conditions; the economy; foreign relations; and relations between the US and Guinea-Bissau. In 1983 the population was estimated at 827,000 with an annual estimated growth rate of 2.2%. 87% of the population was rural, with 13% living in urban areas. The infant mortality rate is 200/1000 with a life expectancy of 42 years. The population comprises several diverse tribal groups, each with its own language, customs, and social organization. Most people are farmers and follow the traditional religious beliefs of their forebears. Most of the nonindigenous population consists of a significant Cape Verdian ethnic community, a small Portuguese community engaged primarily in commerce and civil service, and a few foreign technical consultants. Guinea-Bissau is a small enclave on the west coast of Africa, bounded by Senegal and on the south and east by Guinea (Conakry). Portugal claimed Portuguese Guinea in 1446 when the fleet of Nuno Tristao arrived on the west coast of Africa. In 1956 the African Party for the Independence of Guinea and Cape Verde (PAIGC) was organized clandestinely by the Amilcar Cabral and Raphael Barbosa. The PAIGC moved its headquarters to Conakry in 1960 and began an armed rebellion in 1961. Despite the presence of more than 30,000 Portuguese troops, the PAIGC exercised influence over much of the country by 1972. It established civilian rule in the territory that it controlled and elections took place for a National Assembly. The National Assembly of the PAIGC declared the independence of Guinea-Bissau on September 24, 1973. Portugal granted "de jure" independence on September 10, 1974, when the US recognized the new nation. Guinea-Bissau is a 1-party state. Until May 1984, power was held by a provisional government responsible to a Revolutionary Council. In May 1984 the Revolutionary Council was dissolved, and the 150-member National

  3. Occurrence of Equatorial Plasma Bubbles during Intense Magnetic Storms

    Directory of Open Access Journals (Sweden)

    Chao-Song Huang

    2011-01-01

    Full Text Available An important issue in low-latitude ionospheric space weather is how magnetic storms affect the generation of equatorial plasma bubbles. In this study, we present the measurements of the ion density and velocity in the evening equatorial ionosphere by the Defense Meteorological Satellite Program (DMSP satellites during 22 intense magnetic storms. The DMSP measurements show that deep ion density depletions (plasma bubbles are generated after the interplanetary magnetic field (IMF turns southward. The time delay between the IMF southward turning and the first DMSP detection of plasma depletions decreases with the minimum value of the IMF Bz, the maximum value of the interplanetary electric field (IEF Ey, and the magnitude of the Dst index. The results of this study provide strong evidence that penetration electric field associated with southward IMF during the main phase of magnetic storms increases the generation of equatorial plasma bubbles in the evening sector.

  4. Ebola Virus Imported from Guinea to Senegal, 2014.

    Science.gov (United States)

    Ka, Daye; Fall, Gamou; Diallo, Viviane Cissé; Faye, Ousmane; Fortes, Louise Deguenonvo; Faye, Oumar; Bah, Elhadji Ibrahim; Diallo, Kadia Mbaye; Balique, Fanny; Ndour, Cheikh Tidiane; Seydi, Moussa; Sall, Amadou Alpha

    2017-06-01

    In March 2014, the World Health Organization declared an outbreak of Ebola virus disease in Guinea. In August 2014, a case caused by virus imported from Guinea occurred in Senegal, most likely resulting from nonsecure funerals and travel. Preparedness and surveillance in Senegal probably prevented secondary cases.

  5. A short-term intervention for the treatment of severe malnutrition in a post-conflict country: results of a survey in Guinea Bissau.

    Science.gov (United States)

    Colombatti, Raffaella; Coin, Alessandra; Bestagini, Piero; Vieira, Cesaltina Silva; Schiavon, Laura; Ambrosini, Venceslao; Bertinato, Luigi; Zancan, Lucia; Riccardi, Fabio

    2008-12-01

    To determine (i) the extent of malnutrition and the risk factors for severe malnutrition in Guinea Bissau, a post-conflict country experiencing long-term consequences of civil war; and (ii) the feasibility and effectiveness of a short-term intervention characterized by outpatient treatment with locally produced food for the treatment of severe malnutrition during the rainy season. Social, clinical, nutritional information were collected for children reaching the paediatric outpatient clinic of the Hospital 'Comunità di Sant'Egidio' in Bissau, Guinea Bissau, from 1 July to 12 August 2003. Severely malnourished children (weight-for-age malnutrition. In total, 2642 children were visited (age range: 1 month-17 years). Fever, cough and dermatological problems were the main reasons for access. Social data outlined poor housing conditions: 86.4 % used water from unprotected wells, 97.3 % did not have a bathroom at home, 78.2 % lived in a mud house. Weight-for-age was malnutrition are feasible and successful at low cost; day-care treatment of severe malnutrition with locally produced food is an option that can be tested in other settings.

  6. Application of a TNF-alpha-inhibitor into the scala tympany after cochlear electrode insertion trauma in guinea pigs: preliminary audiologic results.

    Science.gov (United States)

    Ihler, Friedrich; Pelz, Sabrina; Coors, Melanie; Matthias, Christoph; Canis, Martin

    2014-11-01

    Cochlear implantation trauma causes both macroscopic and inflammatory trauma. The aim of the present study was to evaluate the effectiveness of the TNF-alpha inhibitor etanercept applied after cochlear implantation trauma on the preservation of acoustic hearing. Guinea pigs were randomly assigned to three groups receiving cochlear implantation trauma by cochleostomy. In one group, the site was sealed by bone cement with no further treatment. A second group was additionally implanted with an osmotic minipump delivering artificial perilymph into the scala tympani for seven days. In the third group, etanercept 1 mg/ml was added to artificial perilymph. Hearing was assessed by auditory brainstem responses at 2, 4, 6, and 8 kHz prior to and after surgery and on days 3, 5, 7, 14, 28. Fifteen healthy guinea pigs. The trauma led to threshold shifts from 50.3 dB ± 16.3 dB to 68.0 dB ± 19.3 dB. Hearing thresholds were significantly lower in etanercept-treated animals compared to controls on day 28 at 8 kHz and from day 3 onwards at 4 and 2 kHz (p < 0.01; two-way RM ANOVA / Bonferroni t-test). The application of etanercept led to preservation of acoustic hearing after cochlear implantation trauma.

  7. Aerosol Transport Over Equatorial Africa

    Science.gov (United States)

    Gatebe, C. K.; Tyson, P. D.; Annegarn, H. J.; Kinyua, A. M.; Piketh, S.; King, M.; Helas, G.

    1999-01-01

    Long-range and inter-hemispheric transport of atmospheric aerosols over equatorial Africa has received little attention so far. Most aerosol studies in the region have focussed on emissions from rain forest and savanna (both natural and biomass burning) and were carried out in the framework of programs such as DECAFE (Dynamique et Chimie Atmospherique en Foret Equatoriale) and FOS (Fires of Savanna). Considering the importance of this topic, aerosols samples were measured in different seasons at 4420 meters on Mt Kenya and on the equator. The study is based on continuous aerosol sampling on a two stage (fine and coarse) streaker sampler and elemental analysis by Particle Induced X-ray Emission. Continuous samples were collected for two seasons coinciding with late austral winter and early austral spring of 1997 and austral summer of 1998. Source area identification is by trajectory analysis and sources types by statistical techniques. Major meridional transports of material are observed with fine-fraction silicon (31 to 68 %) in aeolian dust and anthropogenic sulfur (9 to 18 %) being the major constituents of the total aerosol loading for the two seasons. Marine aerosol chlorine (4 to 6 %), potassium (3 to 5 %) and iron (1 to 2 %) make up the important components of the total material transport over Kenya. Minimum sulfur fluxes are associated with recirculation of sulfur-free air over equatorial Africa, while maximum sulfur concentrations are observed following passage over the industrial heartland of South Africa or transport over the Zambian/Congo Copperbelt. Chlorine is advected from the ocean and is accompanied by aeolian dust recirculating back to land from mid-oceanic regions. Biomass burning products are transported from the horn of Africa. Mineral dust from the Sahara is transported towards the Far East and then transported back within equatorial easterlies to Mt Kenya. This was observed during austral summer and coincided with the dying phase of 1997/98 El

  8. Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides.

    Science.gov (United States)

    Yamano, Tetsuo; Shimizu, Mitsuru; Noda, Tsutomu

    2005-07-01

    We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders (0.00005-0.5%), while elicitation-threshold doses, which were evaluated using an optimally sensitized group of animals in the multiple-dose studies, ranged over five orders (0.00006-2.8%). In the LLNA, minimum induction doses ranged over more than three orders (0.01-30%). With respect to 13 biocides that were positive in both the GPMT and the LLNA, results were quantitatively compared. When compared after conversion to corresponding area doses (microg/cm), the minimum doses required to elicit skin reaction in guinea pigs were always lower than that for induction in mice with all biocides. Correlation between minimum induction doses from the GPMT and the LLNA seemed poor (r=0.57), while that between minimum induction doses in the LLNA and elicitation-threshold doses in the GPMT was relatively good (r=0.73). The results suggest the possibility to estimate human elicitation-threshold doses, which are definitely lacking in the process of risk assessment for skin-sensitizers, from the data of the LLNA.

  9. Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides

    International Nuclear Information System (INIS)

    Yamano, Tetsuo; Shimizu, Mitsuru; Noda, Tsutomu

    2005-01-01

    We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders (0.00005-0.5%), while elicitation-threshold doses, which were evaluated using an optimally sensitized group of animals in the multiple-dose studies, ranged over five orders (0.00006-2.8%). In the LLNA, minimum induction doses ranged over more than three orders (0.01-30%). With respect to 13 biocides that were positive in both the GPMT and the LLNA, results were quantitatively compared. When compared after conversion to corresponding area doses (μg/cm), the minimum doses required to elicit skin reaction in guinea pigs were always lower than that for induction in mice with all biocides. Correlation between minimum induction doses from the GPMT and the LLNA seemed poor (r = 0.57), while that between minimum induction doses in the LLNA and elicitation-threshold doses in the GPMT was relatively good (r = 0.73). The results suggest the possibility to estimate human elicitation-threshold doses, which are definitely lacking in the process of risk assessment for skin-sensitizers, from the data of the LLNA

  10. Central Equatorial Pacific Experiment (CEPEX)

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    The Earth's climate has varied significantly in the past, yet climate records reveal that in the tropics, sea surface temperatures seem to have been remarkably stable, varying by less than a few degrees Celsius over geologic time. Today, the large warm pool of the western Pacific shows similar characteristics. Its surface temperature always exceeds 27[degree]C, but never 31[degree]C. Heightened interest in this observation has been stimulated by questions of global climate change and the exploration of stabilizing climate feedback processes. Efforts to understand the observed weak sensitivity of tropical sea surface temperatures to climate forcing has led to a number of competing ideas about the nature of this apparent thermostat. Although there remains disagreement on the processes that regulate tropical sea surface temperature, most agree that further progress in resolving these differences requires comprehensive field observations of three-dimensional water vapor concentrations, solar and infrared radiative fluxes, surface fluxes of heat and water vapor, and cloud microphysical properties. This document describes the Central Equatorial Pacific Experiment (CEPEX) plan to collect such observations over the central equatorial Pacific Ocean during March of 1993.

  11. A study on ionospheric scintillation near the EIA crest in relation to equatorial electrodynamics

    Science.gov (United States)

    Chatterjee, S.; Chakraborty, S. K.; Veenadhari, B.; Banola, S.

    2014-02-01

    Equatorial electrojet (EEJ) data, which are considered as a proxy index of equatorial electric field, are analyzed in conjunction with equatorial ionosonde, total electron content (TEC) and scintillation data near the equatorial ionization anomaly (EIA) crest for the equinoctial months of high solar activity years (2011-2012) to identify any precursor index of postsunset evolution of equatorial electron density irregularities and subsequent occurrence of scintillation near the northern EIA crest. Only geomagnetically quiet and normal electrojet days are considered. The diurnal profiles of EEJ on the scintillation days exhibit a secondary enhancement in the afternoon to presunset hours following diurnal peaks. A series of electrodynamical processes conducive for generation of irregularities emerge following secondary enhancement of EEJ. Latitudinal profile of TEC exhibits resurgence in EIA structure around the postsunset period. Diurnal TEC profile near the EIA crest resembles postsunset secondary enhancement on the days with afternoon enhancement in EEJ. Occurrence of equatorial spread F and postsunset scintillation near the EIA crest seems to follow the secondary enhancement events in EEJ. Both the magnitude and duration of enhanced EEJ are found to be important for postsunset intensification of EIA structure and subsequent occurrence of equatorial irregularities. A critical value combining the two may be considered an important precursor for postsunset occurrence of scintillation near the EIA crest. The results are validated using archived data for the years 1989-1990 and explained in terms of modulation effects of enhanced equatorial fountain.

  12. Quantum cloning machines for equatorial qubits

    International Nuclear Information System (INIS)

    Fan Heng; Matsumoto, Keiji; Wang Xiangbin; Wadati, Miki

    2002-01-01

    Quantum cloning machines for equatorial qubits are studied. For the case of a one to two phase-covariant quantum cloning machine, we present the networks consisting of quantum gates to realize the quantum cloning transformations. The copied equatorial qubits are shown to be separable by using Peres-Horodecki criterion. The optimal one to M phase-covariant quantum cloning transformations are given

  13. Role of interannual Kelvin wave propagations in the equatorial Atlantic on the Angola Benguela Current system

    Science.gov (United States)

    Imbol Koungue, Rodrigue Anicet; Illig, Serena; Rouault, Mathieu

    2017-06-01

    The link between equatorial Atlantic Ocean variability and the coastal region of Angola-Namibia is investigated at interannual time scales from 1998 to 2012. An index of equatorial Kelvin wave activity is defined based on Prediction and Research Moored Array in the Tropical Atlantic (PIRATA). Along the equator, results show a significant correlation between interannual PIRATA monthly dynamic height anomalies, altimetric monthly Sea Surface Height Anomalies (SSHA), and SSHA calculated with an Ocean Linear Model. This allows us to interpret PIRATA records in terms of equatorial Kelvin waves. Estimated phase speed of eastward propagations from PIRATA equatorial mooring remains in agreement with the linear theory, emphasizing the dominance of the second baroclinic mode. Systematic analysis of all strong interannual equatorial SSHA shows that they precede by 1-2 months extreme interannual Sea Surface Temperature Anomalies along the African coast, which confirms the hypothesis that major warm and cold events in the Angola-Benguela current system are remotely forced by ocean atmosphere interactions in the equatorial Atlantic. Equatorial wave dynamics is at the origin of their developments. Wind anomalies in the Western Equatorial Atlantic force equatorial downwelling and upwelling Kelvin waves that propagate eastward along the equator and then poleward along the African coast triggering extreme warm and cold events, respectively. A proxy index based on linear ocean dynamics appears to be significantly more correlated with coastal variability than an index based on wind variability. Results show a seasonal phasing, with significantly higher correlations between our equatorial index and coastal SSTA in October-April season.

  14. Vitamin C deficiency in weanling guinea pigs

    DEFF Research Database (Denmark)

    Lykkesfeldt, Jens; Trueba, Gilberto Perez; Poulsen, Henrik E.

    2007-01-01

    Neonates are particularly susceptible to malnutrition due to their limited reserves of micronutrients and their rapid growth. In the present study, we examined the effect of vitamin C deficiency on markers of oxidative stress in plasma, liver and brain of weanling guinea pigs. Vitamin C deficiency...... increased, while protein oxidation decreased (P¼0003). The results show that the selective preservation of brain ascorbate and induction of DNA repair in vitamin C-deficient weanling guinea pigs is not sufficient to prevent oxidative damage. Vitamin C deficiency may therefore be particularly adverse during...

  15. Intraseasonal vertical velocity variation caused by the equatorial wave in the central equatorial Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Horii, T.; Masumoto, Y.; Ueki, I.; PrasannaKumar, S.; Mizuno, K.

    to the theoretical solution of the equatorial waves [Matsuno, 1966] and the phase speed of the baroclinic mode, the wave that has meridional current on the equator with a quasi-biweekly period is the anti-symmetric mixed Rossby-gravity wave. In the wave... and conclusions are given in section 5. 2. Field Experiment, Data, and Methods 2.1. MISMO Ocean Observation [8] The goal of MISMO was to observe atmospheric conditions and variability associated with intraseasonal disturbances and resulting ocean responses...

  16. Guinea pig maximization test

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner

    1985-01-01

    Guinea pig maximization tests (GPMT) with chlorocresol were performed to ascertain whether the sensitization rate was affected by minor changes in the Freund's complete adjuvant (FCA) emulsion used. Three types of emulsion were evaluated: the oil phase was mixed with propylene glycol, saline...

  17. Backscatter measurements of 11-cm equatorial spread-F irregularities

    International Nuclear Information System (INIS)

    Tsunoda, R.T.

    1980-01-01

    In the equatorial F-region ionosphere, a turbulent cascade process has been found to exist that extends from irregularity spatial wavelengths longer than tens of kilometers down to wavelengths as short as 36 cm. To investigate the small-scale regime of wavelengths less than 36 cm, an equatorial radar experiment was conducted using a frequency of 1320 MHz that corresponds to an irregularity wavelength of 11 cm. The first observations of radar backscatter from 11-cm field-aligned irregularities (FAI) are described. These measurements extend the spatial wavelength regime of F-region FAI to lengths that approach both electron gyroradius and the Debye length. Agreement of these results with the theory of high-frequency drift waves suggests that these observations may be unique to the equatorial ionosphere. That is, the requirement of low electron densities for which the theroy calls may preclude the existence of 11-cm FAI elsewhere in the F-region ionosphere, except in equatorial plasma bubbles

  18. Estudio de productos forestales no maderables en tres mercados de Guinea Ecuatorial

    Directory of Open Access Journals (Sweden)

    Obama Ondo, Crisantos

    2001-12-01

    Full Text Available The presence of vegetable oils, wild fruits, spices, medicinal plants, plant stimulants and melongos in the markets of Ebibeyín, Bata and Malabo of Equatorial-Guinea have been studied, as remarkable non-wood forest products from these markets. The possible impact of the uses of these products on the natural environments are discussed. Some suggestions about the improvement and development of the non-wood forest products in Equatorial-Guinea are given.Se han tomado datos en los mercados de Ebibeyín, Bata y Malabo, en Guinea Ecuatorial, sobre aceites vegetales, frutos silvestres comestibles, condimentos de origen vegetal, plantas medicinales, plantas estimulantes y melongos, como principales productos forestales no maderables en venta en dichos mercados. Se discuten cuestiones generales relacionadas con el medio natural y el posible impacto en él del uso de estos productos. El estudio finaliza con unas sugerencias sobre temas relativos a la mejora y desarrollo del sector de los productos forestales no maderables en Guinea Ecuatorial.

  19. Lagrangian mixed layer modeling of the western equatorial Pacific

    Science.gov (United States)

    Shinoda, Toshiaki; Lukas, Roger

    1995-01-01

    Processes that control the upper ocean thermohaline structure in the western equatorial Pacific are examined using a Lagrangian mixed layer model. The one-dimensional bulk mixed layer model of Garwood (1977) is integrated along the trajectories derived from a nonlinear 1 1/2 layer reduced gravity model forced with actual wind fields. The Global Precipitation Climatology Project (GPCP) data are used to estimate surface freshwater fluxes for the mixed layer model. The wind stress data which forced the 1 1/2 layer model are used for the mixed layer model. The model was run for the period 1987-1988. This simple model is able to simulate the isothermal layer below the mixed layer in the western Pacific warm pool and its variation. The subduction mechanism hypothesized by Lukas and Lindstrom (1991) is evident in the model results. During periods of strong South Equatorial Current, the warm and salty mixed layer waters in the central Pacific are subducted below the fresh shallow mixed layer in the western Pacific. However, this subduction mechanism is not evident when upwelling Rossby waves reach the western equatorial Pacific or when a prominent deepening of the mixed layer occurs in the western equatorial Pacific or when a prominent deepening of the mixed layer occurs in the western equatorial Pacific due to episodes of strong wind and light precipitation associated with the El Nino-Southern Oscillation. Comparison of the results between the Lagrangian mixed layer model and a locally forced Eulerian mixed layer model indicated that horizontal advection of salty waters from the central Pacific strongly affects the upper ocean salinity variation in the western Pacific, and that this advection is necessary to maintain the upper ocean thermohaline structure in this region.

  20. Guinea pig complement potently measures vibriocidal activity of human antibodies in response to cholera vaccines.

    Science.gov (United States)

    Kim, Kyoung Whun; Jeong, Soyoung; Ahn, Ki Bum; Yang, Jae Seung; Yun, Cheol-Heui; Han, Seung Hyun

    2017-12-01

    The vibriocidal assay using guinea pig complement is widely used for the evaluation of immune responses to cholera vaccines in human clinical trials. However, it is unclear why guinea pig complement has been used over human complement in the measurement of vibriocidal activity of human sera and there have not been comparison studies for the use of guinea pig complement over those from other species. Therefore, we comparatively investigated the effects of complements derived from human, guinea pig, rabbit, and sheep on vibriocidal activity. Complements from guinea pig, rabbit, and human showed concentration-dependent vibriocidal activity in the presence of quality control serum antibodies. Of these complements, guinea pig complement was the most sensitive and effective over a wide concentration range. When the vibriocidal activity of complements was measured in the absence of serum antibodies, human, sheep, and guinea pig complements showed vibriocidal activity up to 40-fold, 20-fold, and 1-fold dilution, respectively. For human pre- and post-vaccination sera, the most potent vibriocidal activity was observed when guinea pig complement was used. In addition, the highest fold-increases between pre- and post- vaccinated sera were obtained with guinea pig complement. Furthermore, human complement contained a higher amount of V. cholerae- and its lipopolysaccharide-specific antibodies than guinea pig complement. Collectively, these results suggest that guinea pig complements are suitable for vibriocidal assays due to their high sensitivity and effectiveness to human sera.

  1. Mesothelium of Reissner's membrane in guinea pigs

    DEFF Research Database (Denmark)

    Qvortrup, K; Rostgaard, Jørgen

    1990-01-01

    The mesothelial cells of Reissner's membrane in guinea pigs were found to be connected by junctional complexes. No cell discontinuities or gaps were observed by scanning or transmission electron microscopy. These results are not in accordance with previous studies. They were achieved by in vivo...

  2. A novel point-of-care testing strategy for sexually transmitted infections among pregnant women in high-burden settings: results of a feasibility study in Papua New Guinea.

    Science.gov (United States)

    Badman, Steven G; Vallely, Lisa M; Toliman, Pamela; Kariwiga, Grace; Lote, Bomesina; Pomat, William; Holmer, Caroline; Guy, Rebecca; Luchters, Stanley; Morgan, Chris; Garland, Suzanne M; Tabrizi, Sepehr; Whiley, David; Rogerson, Stephen J; Mola, Glen; Wand, Handan; Donovan, Basil; Causer, Louise; Kaldor, John; Vallely, Andrew

    2016-06-06

    Sexually transmitted and genital infections in pregnancy are associated with an increased risk of adverse maternal and neonatal health outcomes. High prevalences of sexually transmitted infections have been identified among antenatal attenders in Papua New Guinea. Papua New Guinea has amongst the highest neonatal mortality rates worldwide, with preterm birth and low birth weight major contributors to neonatal mortality. The overall aim of our study was to determine if a novel point-of-care testing and treatment strategy for the sexually transmitted and genital infections Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) and Bacterial vaginosis (BV) in pregnancy is feasible in the high-burden, low-income setting of Papua New Guinea. Women attending their first antenatal clinic visit were invited to participate. CT/NG and TV were tested using the GeneXpert platform (Cepheid, USA), and BV tested using BVBlue (Gryphus Diagnostics, USA). Participants received same-day test results and antibiotic treatment as indicated. Routine antenatal care including HIV and syphilis screening were provided. Point-of-care testing was provided to 125/222 (56 %) of women attending routine antenatal care during the three-month study period. Among the 125 women enrolled, the prevalence of CT was 20.0 %; NG, 11.2 %; TV, 37.6 %; and BV, 17.6 %. Over half (67/125, 53.6 %) of women had one or more of these infections. Most women were asymptomatic (71.6 %; 47/67). Women aged 24 years and under were more likely to have one or more STI compared with older women (odds ratio 2.38; 95 % CI: 1.09, 5.21). Most women with an STI received treatment on the same day (83.6 %; 56/67). HIV prevalence was 1.6 % and active syphilis 4.0 %. Point-of-care STI testing and treatment using a combination of novel, newly-available assays was feasible during routine antenatal care in this setting. This strategy has not previously been evaluated in any setting and offers the

  3. Petroleum service projects in the Gulf of Guinea

    Science.gov (United States)

    Ken-Worgu, Kenneth Chukwumeka

    2011-07-01

    The goal of this record of study is to examine the major facets involved in managing several petroleum service projects located in three different countries in the Gulf of Guinea simultaneously, while effectively engaging in business development activities for the Oil and Industrial Services Group (OIS). This work also furnishes adequate background on related subject matters to enable understanding of the projects presented. The petroleum services sector is the back bone of the oil and gas industry. Services companies are vital to the success of all petroleum and energy producers in the USA, the Gulf of Guinea and the world. There is a need and demand for these service companies because they play various roles such as logistics, drilling, construction, dredging, pipe laying, procurement, food supply, human resource supply, etc. The Gulf of Guinea comprises of countries from west and central Africa. This project was limited to Nigeria, Equatorial Guinea and Cameroon. This area holds the largest petroleum reserves in Africa and plays a vital role in the global supply of petroleum. The Oil and Industrial Services Group (OIS), plans to establish herself as one of the leading petroleum service companies in this gulf. To manage this expansion, I have taken the role of Gulf of Guinea manager to apply my background as a petroleum engineer as well as my business skills to build a successful division of the company. This work provides a record of study of the management of services, projects and contracts carried out by the OIS group in the gulf of Guinea. The following are the specific projects in the Gulf of Guinea that I participated in: Managing delivering, maintenance and marketing of offshore vessels, Offshore pipe laying project, Integrated pipeline maintenance project, Development a petroleum technical training facilities, Agbami pipe insulation project, Engineering lift project and Capital budgeting analysis for potential investments. The details of the specific

  4. Photoelectric panel with equatorial mounting of drive

    Science.gov (United States)

    Kukhta, M. S.; Krauinsh, P. Y.; Krauinsh, D. P.; Sokolov, A. P.; Mainy, S. B.

    2018-03-01

    The relevance of the work is determined by the need to create effective models for sunny energy. The article considers a photoelectric panel equipped with a system for tracking the sun. Efficiency of the system is provided by equatorial mounting, which compensates for the rotation of the Earth by rotating the sunny panel in the plane of the celestial equator. The specificity of climatic and geographical conditions of Tomsk is estimated. The dynamics of power variations of photoelectric panels with equatorial mounting during seasonal fluctuations in Tomsk is calculated. A mobile photovoltaic panel with equatorial mounting of the drive has been developed. The methods of design strategy for placing photovoltaic panels in the architectural environment of the city are presented. Key words: sunny energy, photovoltaics, equatorial mounting, mechatronic model, wave reducer, electric drive.

  5. Tropospheric ozone over Equatorial Africa: regional aspects from the MOZAIC data

    Directory of Open Access Journals (Sweden)

    B. Sauvage

    2005-01-01

    Full Text Available We analyze ozone observations recorded over Equatorial Africa between April 1997 and March 2003 by the MOZAIC programme, providing the first ozone climatology deriving from continental in-situ data over this region. Three-dimensional streamlines strongly suggests connections between the characteristics of the ozone monthly mean vertical profiles, the most persistent circulation patterns in the troposphere over Equatorial Africa (on a monthly basis such as the Harmattan, the African Easterly Jet, the Trades and the regions of ozone precursors emissions by biomass burning. During the biomass burning season in each hemisphere, the lower troposphere exhibits layers of enhanced ozone (i.e. 70 ppbv over the coast of Gulf of Guinea in December-February and 85 ppbv over Congo in June-August. The characteristics of the ozone monthly mean vertical profiles are clearly connected to the regional flow regime determined by seasonal dynamic forcing. The mean ozone profile over the coast of Gulf of Guinea in the burning season is characterized by systematically high ozone below 650hPa ; these are due to the transport by the Harmattan and the AEJ of the pollutants originating from upwind fires. The confinement of high ozone to the lower troposphere is due to the high stability of the Harmattan and the blocking Saharan anticyclone which prevents efficient vertical mixing. In contrast, ozone enhancements observed over Central Africa during the local dry season (June-August are not only found in the lower troposphere but throughout the troposphere. Moreover, this study highlights a connection between the regions of the coast of Gulf of Guinea and regions of Congo to the south that appears on a semi annual basis. Vertical profiles in wet-season regions exhibit ozone enhancements in the lower troposphere due to biomass burning products transport from fires situated in the opposite dry-season hemisphere.

  6. Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus).

    Science.gov (United States)

    Williams, Wendy R; Johnston, Matthew S; Higgins, Sarah; Izzo, Angelo A; Kendall, Lon V

    2016-01-01

    The guinea pig is a common animal model that is used in biomedical research to study a variety of systems, including hormonal and immunological responses, pulmonary physiology, corticosteroid response and others. However, because guinea pigs are evolutionarily a prey species, they do not readily show behavioral signs of disease, which can make it difficult to detect illness in a laboratory setting. Minimally invasive blood tests, such as complete blood counts and plasma biochemistry assays, are useful in both human and veterinary medicine as an initial diagnostic technique to rule in or rule out systemic illness. In guinea pigs, phlebotomy for such tests often requires that the animals be anesthetized first. The authors evaluated hematological and plasma biochemical effects of two anesthetic agents that are commonly used with guinea pigs in a research setting: isoflurane and a combination of ketamine and xylazine. Hematological and plasma biochemical parameters were significantly different when guinea pigs were under either anesthetic, compared to when they were unanesthetized. Plasma proteins, liver enzymes, white blood cells and red blood cells appeared to be significantly altered by both anesthetics, and hematological and plasma biochemical differences were greater when guinea pigs were anesthetized with the combination of ketamine and xylazine than when they were anesthetized with isoflurane. Overall these results indicate that both anesthetics can significantly influence hematological and plasma biochemical parameters in guinea pigs.

  7. Functional analysis of guinea pig β1-adrenoceptor.

    Science.gov (United States)

    Tanaka, Yoshio; Takahashi, Hiromi; Shibata, Sayuri; Namiki, Kana; Kimura, Sadao; Koike, Katsuo; Kasuya, Yoshitoshi

    2011-12-01

    Although similarity of pharmacological responses to certain stimuli between guinea pigs and humans has been reported, this has been poorly defined by a molecular biological approach. In this study, we cloned the gene of guinea pig ?1-adrenoceptor (ADRB1). The deduced amino acid sequence of guinea pig ADRB1 (467-aa) showed 91% and 92% identity with the human and rat ADRB1 sequences, respectively. Using HEK293T cells expressing guinea pig, human and rat ADRB1s independently, we elucidated the functional characteristics of each ADRB1. The ligand-binding profiles and the concentration-response relationships for isoprenaline-induced cyclic adenosine monophosphate (cAMP) production were similar among the three ADRB1s. Isoprenaline also induced phosphorylation of extracellular-signal related kinases (ERK) through ADRB1s in a concentration-dependent manner. The minimum effective concentration of isoprenaline for phosphorylation of ERK, through guinea pig ADRB1 was the same as through human ADRB1, but markedly lower than that of through rat ADRB1. ERK phosphorylation through guinea pig ADRB1 was sensitive to pertussis toxin, a dominant-negative ras and PD98059, indicating that a G(i)-mediated pathway is involved in the ADRB1/ERK signaling loop. These results suggest that the G(i)-coupling efficacy of guinea pig and human ADRB1s may be higher than that of rat ADRB1.

  8. CONVECTIVE BURSTS AND THE COUPLING OF SATURN'S EQUATORIAL STORMS AND INTERIOR ROTATION

    International Nuclear Information System (INIS)

    Heimpel, Moritz; Aurnou, Jonathan M.

    2012-01-01

    Temporal variations of Saturn's equatorial jet and magnetic field hint at rich dynamics coupling the atmosphere and the deep interior. However, it has been assumed that rotation of the interior dynamo must be steady over tens of years of modern observations. Here we use a numerical convection model and scaling estimates to show how equatorial convective bursts can transfer angular momentum to the deeper interior. The numerical model allows angular momentum transfer between a fluid outer spherical shell and a rigid inner sphere. Convection drives a prograde equatorial jet exhibiting quasiperiodic bursts that fill the equatorial volume outside the tangent cylinder. For each burst strong changes in the equatorial surface velocity are associated with retrograde torque on the inner sphere. Our results suggest that Saturn's Great White Spot, a giant storm that was observed to fill the equatorial region in 1990, could mobilize a volume of fluid carrying roughly 15% of Saturn's moment of inertia. Conservation of angular momentum then implies that a 20% change in the equatorial jet angular velocity could change the average interior rotation rate by about 0.1%—roughly an order of magnitude less than the apparent rotation rate changes associated with Saturn's kilometric radio (SKR) signal. However, if the SKR signal originates outside the liquid metal core in a 'planetary tachocline' that separates the layer of fast zonal flow from the magnetically controlled and slowly convecting deep interior, then convective bursts can provide a possible mechanism for the observed ∼1% SKR changes.

  9. The guinea-pig

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Maibach, H I; Anjo, M D

    1980-01-01

    14C ring-labelled hydrocortisone, testosterone and benzoic acid dissolved in acetone were applied to the backs of guinea-pigs (4 microgram/cm2). Percutaneous absorption was quantified by following the excretion of tracer in urine and faeces for 5 days. Absorption of hydrocortisone and benzoic acid...... was 2.4% (s.d. = 0.5; n = 3) and 31.4% (s.d. = 9.1; n = 3) of the applied dose respectively, similar to published human absorption data. Testosterone was absorbed to a greater extent in guinea-pigs (34.9% +/- 5.4; n = 5) than man. A thioglycollate based depilatory cream significantly increased the skin...

  10. Surface currents in the equatorial Indian Ocean during spring and fall - An altimetry based analysis

    Digital Repository Service at National Institute of Oceanography (India)

    Antony, M.K.; Somayajulu, Y.K.

    This communication presents the results of a study aimed at investigating the nature and variability of surface currents in the equatorial Indian Ocean between 5 degrees N and 5 degrees S during spring and fall seasons. Geostrophic surface currents...

  11. ECG telemetry in conscious guinea pigs.

    Science.gov (United States)

    Ruppert, Sabine; Vormberge, Thomas; Igl, Bernd-Wolfgang; Hoffmann, Michael

    2016-01-01

    During preclinical drug development, monitoring of the electrocardiogram (ECG) is an important part of cardiac safety assessment. To detect potential pro-arrhythmic liabilities of a drug candidate and for internal decision-making during early stage drug development an in vivo model in small animals with translatability to human cardiac function is required. Over the last years, modifications/improvements regarding animal housing, ECG electrode placement, and data evaluation have been introduced into an established model for ECG recordings using telemetry in conscious, freely moving guinea pigs. Pharmacological validation using selected reference compounds affecting different mechanisms relevant for cardiac electrophysiology (quinidine, flecainide, atenolol, dl-sotalol, dofetilide, nifedipine, moxifloxacin) was conducted and findings were compared with results obtained in telemetered Beagle dogs. Under standardized conditions, reliable ECG data with low variability allowing largely automated evaluation were obtained from the telemetered guinea pig model. The model is sensitive to compounds blocking cardiac sodium channels, hERG K(+) channels and calcium channels, and appears to be even more sensitive to β-blockers as observed in dogs at rest. QT interval correction according to Bazett and Sarma appears to be appropriate methods in conscious guinea pigs. Overall, the telemetered guinea pig is a suitable model for the conduct of early stage preclinical ECG assessment. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Arrangement of Renal Arteries in Guinea Pig.

    Science.gov (United States)

    Mazensky, David; Flesarova, Slavka

    2017-03-01

    The aim of this study was to describe origin, localization, and variations of renal arteries in guinea pig. The study was carried out on 26 adult guinea pigs. We prepared corrosion casts of the guinea pig arterial system. Batson's corrosion casting kit no. 17 was used as the casting medium. In 57.7% of specimens, a. renalis dextra was present as a single vessel with different level of its origin from aorta abdominalis. In 38.5% of specimens, two aa. renales dextrae were present with variable origin and arrangement. The presence of three aa. renales dextrae we found in one specimen. In 76.9% of specimens, a. renalis sinistra was present as a single vessel with different level of its origin from aorta abdominalis and variable arrangement. In 23.1% of specimens, we found two aa. renales sinistrae with variable origin and arrangement. The anatomical knowledge of the renal arteries, and its variations are of extreme importance for the surgeon that approaches the retroperitoneal region in several experiments, results of which are extrapolated in human. This is the first work dealing with the description of renal arteries arrangement in guinea pig. Anat Rec, 300:556-559, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective

    Directory of Open Access Journals (Sweden)

    Jobling Mark A

    2007-07-01

    Full Text Available Abstract Background The geographic and ethnolinguistic differentiation of many African Y-chromosomal lineages provides an opportunity to evaluate human migration episodes and admixture processes, in a pan-continental context. The analysis of the paternal genetic structure of Equatorial West Africans carried out to date leaves their origins and relationships unclear, and raises questions about the existence of major demographic phenomena analogous to the large-scale Bantu expansions. To address this, we have analysed the variation of 31 binary and 11 microsatellite markers on the non-recombining portion of the Y chromosome in Guinea-Bissau samples of diverse ethnic affiliations, some not studied before. Results The Guinea-Bissau Y chromosome pool is characterized by low haplogroup diversity (D = 0.470, sd 0.033, with the predominant haplogroup E3a*-M2 shared among the ethnic clusters and reaching a maximum of 82.2% in the Mandenka people. The Felupe-Djola and Papel groups exhibit the highest diversity of lineages and harbor the deep-rooting haplogroups A-M91, E2-M75 and E3*-PN2, typical of Sahel's more central and eastern areas. Their genetic distinction from other groups is statistically significant (P = 0.01 though not attributable to linguistic, geographic or religious criteria. Non sub-Saharan influences were associated with the presence of haplogroup R1b-P25 and particular lineages of E3b1-M78. Conclusion The predominance and high diversity of haplogroup E3a*-M2 suggests a demographic expansion in the equatorial western fringe, possibly supported by a local agricultural center. The paternal pool of the Mandenka and Balanta displays evidence of a particularly marked population growth among the Guineans, possibly reflecting the demographic effects of the agriculturalist lifestyle and their putative relationship to the people that introduced early cultivation practices into West Africa. The paternal background of the Felupe-Djola and Papel

  14. Ongoing Analysis of Jupiter's Equatorial Hotspots and Plumes from Cassini

    Science.gov (United States)

    Choi, D. S.; Showmwn, A. P.; Vasavada, A. R.; Simon-Miller, A. A.

    2012-01-01

    We present updated results from our ongoing analysis of Cassini observations of Jupiter's equatorial meteorology. For two months preceding the spacecraft's closest approach of the planet, the ISS instrument onboard Cassini regularly imaged the atmosphere of Jupiter. We created time-lapse movies from this period that show the complex activity and interactions of the equatorial atmosphere. During this period, hot spots exhibited significant variations in size and shape over timescales of days and weeks. Some of these changes appear to be a result of interactions with passing vortex systems in adjacent latitudes. Strong anticyclonic gyres to the southeast of the dark areas converge with flow from the west and appear to circulate into a hot spot at its southwestern corner.

  15. Plasma instabilities multifrequency study in equatorial electrojet

    International Nuclear Information System (INIS)

    Hanuise, C.

    1983-01-01

    In this thesis, multifrequential HF coherent radar results are presented, in the field plasma instabilities in equatorial electrojet. In a first part, characteristics of the irregularities observed either at the 3 meter wavelength by VHF radars, either at other wavelengths during pinpoint experiments, or in-situ by probe rockets are recalled. Theoretical studies progressed and are presented, at the same time with these experimental observations: instability linear theory, non linear theories, HF radar specificity, and problems associated to HF waves propagation and refraction in ionosphere. Original experimental results from Ethiopia are gathered in the second part. Plasma instability has been studied in different geophysical conditions and Doppler spectra characteristics are presented for each one of them. These characteristics are completely different according to the various cases; they are also different according to wether observations are made during the day in normal conditions (electric field pointed to the east at the equator) or in counter-electrojet conditions (electric field pointed to the west). The last part is concerned with theoretical interpretation of the previous results. A comprehensive view of the instability physical mechanisms, according to the geophysical conditions encountered, has been allowed by our results, VHF radar measurements at Jicamarca, or in situ probe measurements on the whole. Irregularities study has been limited to the E region [fr

  16. Onset conditions for equatorial spread F

    International Nuclear Information System (INIS)

    Mendillo, M.; Baumgardner, J.; Xiaoqing Pi; Sultan, P.J.; Tsunoda, R.

    1992-01-01

    The problem of day-to-day variability in the occurrence of equatorial spread F (ESF) is addressed using multidiagnostic observations and semiempirical modeling. The observational results are derived from a two-night case study of ESF onset conditions observed at Kwajalein Atoll (Marshall Islands) using the ALTAIR incoherent scatter radar and all-sky optical imaging techniques. The major difference between nights when ESF instabilities did not occur (August 14, 1988) and did occur (August 15, 1988) in the Kwajalein sector was that the northern meridional gradient of 6300-angstrom airglow was reduced on the night of limited ESF activity. Modeling results suggest that this unusual airglow pattern is due to equatorward neutral winds. Previous researchers have shown that transequatorial thermospheric winds can exert a control over ESF seasonal and longitudinal occurrence patterns by inhibiting Rayleigh-Taylor instability growth rates. They present evidence to suggest that this picture can be extended to far shorter time scales, namely, that 'surges' in transequatoral winds acting over characteristic times of a few hours to a day can result in a stabilizing influence upon irregularity growth rates. The seemingly capricious nature of ESF onset may thus be controlled, in part, by the inherent variability of low-latitude thermospheric winds

  17. Effects of ultraviolet irradiation on skin of guinea pig

    International Nuclear Information System (INIS)

    Zhang Wenwen; Chen Qiang; Li Peng; Ling Ling; Lin Xiaochen; Ren Shuping; Liu Yajuan; Li Yun

    2008-01-01

    Objective: To explore the adverse effects of ultraviolet B (UV-B) on the skin of guinea pig. Methods: Guinea pig skin was irradiated with UV-B, the skin changes in external appearance, pathology, and the contents of OH and O 2 - produced in the skin were determined to study the adverse effects of UV-B on the guinea pig skin. Results: UV-B caused red swelling and desquamation of skin, with the increasing of the UV-B irradiation, the cells in stratum spinosum began to proliferate vigorously, the MDA and ROS contents in UVB radiation group were significantly higher than those in control group (P<0.05). Conclusion: UV-B can cause injury to guinea pig skin and has the potential to produce skin cancer. (authors)

  18. Saturn's equatorial jet structure from Cassini/ISS

    Science.gov (United States)

    García-Melendo, Enrique; Legarreta, Jon; Sánchez-Lavega, Agustín.; Pérez-Hoyos, Santiago; Hueso, Ricardo

    2010-05-01

    Detailed wind observations of the equatorial regions of the gaseous giant planets, Jupiter and Saturn, are crucial for understanding the basic problem of the global circulation and obtaining new detailed information on atmospheric phenomena. In this work we present high resolution data of Saturn's equatorial region wind profile from Cassini/ISS images. To retrieve wind measurements we applied an automatic cross correlator to image pairs taken by Cassini/ISS with the MT1, MT2, MT3 filters centred at the respective three methane absorbing bands of 619nm, 727nm, and 889nm, and with the adjacent continuum CB1, CB2, and CB3 filters. We obtained a complete high resolution coverage of Saturn's wind profile in the equatorial region. The equatorial jet displays an overall symmetric structure similar to that shown the by same region in Jupiter. This result suggests that, in accordance to some of the latest compressible atmosphere computer models, probably global winds in gaseous giants are deeply rooted in the molecular hydrogen layer. Wind profiles in the methane absorbing bands show the effect of strong vertical shear, ~40m/s per scale height, confirming previous results and an important decay in the wind intensity since the Voyager era (~100 m/s in the continuum and ~200 m/s in the methane absorbing band). We also report the discovery of a new feature, a very strong and narrow jet on the equator, about only 5 degrees wide, that despite the vertical shear maintains its intensity (~420 m/s) in both, the continuum and methane absorbing band filters. Acknowledgements: Work supported by the Spanish MICIIN AYA2009-10701 with FEDER and Grupos Gobierno Vasco IT-464-07.

  19. Equatorial waves in the stratosphere of Uranus

    Science.gov (United States)

    Hinson, David P.; Magalhaes, Julio A.

    1991-01-01

    Analyses of radio occultation data from Voyager 2 have led to the discovery and characterization of an equatorial wave in the Uranus stratosphere. The observed quasi-periodic vertical atmospheric density variations are in close agreement with theoretical predictions for a wave that propagates vertically through the observed background structure of the stratosphere. Quantitative comparisons between measurements obtained at immersion and at emersion yielded constraints on the meridional and zonal structure of the wave; the fact that the two sets of measurements are correlated suggests a wave of planetary scale. Two equatorial wave models are proposed for the wave.

  20. Modeling Global Ocean Biogeochemistry With Physical Data Assimilation: A Pragmatic Solution to the Equatorial Instability

    Science.gov (United States)

    Park, Jong-Yeon; Stock, Charles A.; Yang, Xiaosong; Dunne, John P.; Rosati, Anthony; John, Jasmin; Zhang, Shaoqing

    2018-03-01

    Reliable estimates of historical and current biogeochemistry are essential for understanding past ecosystem variability and predicting future changes. Efforts to translate improved physical ocean state estimates into improved biogeochemical estimates, however, are hindered by high biogeochemical sensitivity to transient momentum imbalances that arise during physical data assimilation. Most notably, the breakdown of geostrophic constraints on data assimilation in equatorial regions can lead to spurious upwelling, resulting in excessive equatorial productivity and biogeochemical fluxes. This hampers efforts to understand and predict the biogeochemical consequences of El Niño and La Niña. We develop a strategy to robustly integrate an ocean biogeochemical model with an ensemble coupled-climate data assimilation system used for seasonal to decadal global climate prediction. Addressing spurious vertical velocities requires two steps. First, we find that tightening constraints on atmospheric data assimilation maintains a better equatorial wind stress and pressure gradient balance. This reduces spurious vertical velocities, but those remaining still produce substantial biogeochemical biases. The remainder is addressed by imposing stricter fidelity to model dynamics over data constraints near the equator. We determine an optimal choice of model-data weights that removed spurious biogeochemical signals while benefitting from off-equatorial constraints that still substantially improve equatorial physical ocean simulations. Compared to the unconstrained control run, the optimally constrained model reduces equatorial biogeochemical biases and markedly improves the equatorial subsurface nitrate concentrations and hypoxic area. The pragmatic approach described herein offers a means of advancing earth system prediction in parallel with continued data assimilation advances aimed at fully considering equatorial data constraints.

  1. Effect of geomagnetic storm conditions on the equatorial ionization anomaly and equatorial temperature anomaly

    Science.gov (United States)

    Bharti, Gaurav; Bag, T.; Sunil Krishna, M. V.

    2018-03-01

    The effect of the geomagnetic storm on the equatorial ionization anomaly (EIA) and equatorial temperature anomaly (ETA) has been studied using the atomic oxygen dayglow emissions at 577.7 nm (OI 557.7 nm) and 732.0 nm (OII 732.0 nm). For the purpose of this study, four intense geomagnetic storms during the ascending phase of solar cycle 24 have been considered. This study is primarily based on the results obtained using photochemical models with necessary inputs from theoretical studies and experimental observations. The latest reaction rate coefficients, quantum yields and the corresponding cross-sections have also been incorporated in these models. The volume emission rate of airglow emissions has been calculated using the neutral densities from NRLMSISE-00 and charged densities from IRI-2012 model. The modeled volume emission rate (VER) for OI 557.7 nm shows a positive correlation with the Dst index at 150 km and negative correlation with Dst at 250 and 280 km altitudes. Latitudinal profile of the greenline emission rate at different altitudes show a distinct behaviour similar to what has been observed in EIA with crests on either sides of the equator. The EIA crests are found to show poleward movement in the higher altitude regions. The volume emission rate of 732.0 nm emission shows a strong enhancement during the main phase of the storm. The changes observed in the airglow emission rates are explained with the help of variations induced in neutral densities and parameters related to EIA and ETA. The latitudinal variation of 732.0 nm emission rate is correlated to the variability in EIA during the storm period.

  2. The preparation of recombinant interleukin-6 and its protection for irradiated guinea-pigs

    International Nuclear Information System (INIS)

    Wang Junfu; Zhang Jie; Zhang Jianhua; Feng Jinbo; Xu Jie; Wang Baohong

    2002-01-01

    Objective: To purify recombinant human interleukin-6 from gene-engineered E. coli and study the effects of IL-6 on survival period and platelet count of irradiated guinea-pigs. Methods: Recombinant human IL-6 was expressed in gene-engineered E. coli and purified with reversed phase chromatography. Purified IL-6 was then administered to irradiated guinea-pig. Results: IL-6 could significantly prolong the survival period and increase the platelet count of irradiated guinea-pigs. Conclusion: IL-6 showed its effective protection for irradiated guinea-pigs

  3. Coccolithophores in the equatorial Atlantic Ocean

    DEFF Research Database (Denmark)

    Kinkel, Hanno; Baumann, K.-H.; Cepek, M.

    2000-01-01

    with each other. In general, the living coccolithophores in the surface and subsurface waters show considerable variation in cell numbers and distribution patterns. Cell densities reached a maximum of up to 300 x 10 coccospheres/l in the upwelling area of the equatorial Atlantic. Here, Emiliania huxleyi...

  4. Lamington, Papua New Guinea Images

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dormant stratovolcano in Papua New Guinea suddenly exploded in 1951. Nuees ardentes (glowing avalanches) shot down the mountain at 100 km per hour, devastated...

  5. Climatically-controlled siliceous productivity in the eastern Gulf of Guinea during the last 40 000 yr

    Directory of Open Access Journals (Sweden)

    X. Crosta

    2012-03-01

    Full Text Available Opal content and diatom assemblages were analysed in core GeoB4905-4 to reconstruct siliceous productivity changes in the eastern Gulf of Guinea during the last 40 000 yr. Opal and total diatom accumulation rates presented low values over the considered period, except during the Last Glacial Maximum and between 15 000 calendar years Before Present (15 cal. ka BP and 5.5 cal. ka BP, the so-called African Humid Period, when accumulation rates of brackish and freshwater diatoms at the core site were highest. Conversely, accumulation rates of windblown diatoms exhibited an opposite pattern with higher values before and after the African Humid Period and greatest values during Heinrich Events, the Younger Dryas and since 5.5 cal. ka BP.

    Our results demonstrate that siliceous productivity in the eastern Gulf of Guinea was directly driven by the nutrient load from local rivers, whose discharges were forced by precipitation changes over western Equatorial Africa and/or modification of the fluvio-deltaic systems forced by sea level changes. Precipitation in this region is controlled by the West African monsoon which is, in turn, partly dependent on the presence and intensity of the Atlantic Cold Tongue (ACT. Our results therefore suggest that the ACT was weakened, warmer trade winds were less vigorous, and cloud convection and precipitation were greater during the AHP though centennial-to-millennial timescale dry events were observed at ∼10 cal. ka BP, ∼8.5 cal. ka BP and ∼6 cal. ka BP. Conversely, the ACT was more intense, trade winds were more vigorous and African climate was more arid during H1, the Younger Dryas and after 5.5 cal. ka BP into the present.

  6. 28th Africa Cup of Nations (Gabon/Equatorial Guinea - 2012 ...

    African Journals Online (AJOL)

    Some recommendations were made to include “football eclipse” for a period to enable Nigeria reflect and plan for her football and a restructuring of the Nigerian Professional League to make it more productive and attractive. Keywords: Charlatans; Dogged determination; Landscape; Legion; Match rusty; Minnows; Tourney.

  7. Determination of stable and radioactive isotopes in rain water for the equatorial and Sahel zones

    International Nuclear Information System (INIS)

    Baudet, J.; Lesne, H.

    1975-01-01

    The extension of desert zones to detriment of Sahel zones lead to look for the circuit followed by water vapor between its principal source, i.e. the Guinea Gulf, and the place where it is changed in precipitation. Samples of rainwater have been collected in Abidjan, Ouagadougou, and Niamey when the Intertropical Front was beginning its moving down towards the South, i.e. at the end of the rainy season for the Sahel zone, and at the beginning of the small rainy season for the equatorial zone. The analysis of these tritium, deuterium and oxygen-18 contents show that: the rains collected in Abidjan comes mainly from Ocean; the rains collected in Ouagadougou and Niamey have followed a long journey above the continent, as shown by the tritium content. The water evaporated in the Guinea Gulf is condensed in the convergence zone above Cameroon, and mixed with re-evaporated continental water. The content of one of the Ouagadougou sample shows that the rain issued from a local cumulonimbus has drawn a part of its water from the stratosphere [fr

  8. The Role of Reversed Equatorial Zonal Transport in Terminating an ENSO Event

    Science.gov (United States)

    Chen, H. C.; Hu, Z. Z.; Huang, B.; Sui, C. H.

    2016-02-01

    In this study, we demonstrate that a sudden reversal of anomalous equatorial zonal current at the peaking ENSO phase triggers the rapid termination of an ENSO event. Throughout an ENSO cycle, the anomalous equatorial zonal current is strongly controlled by the concavity of the anomalous thermocline meridional structure near the equator. During the ENSO developing phase, the anomalous zonal current in the central and eastern Pacific generally enhances the ENSO growth through its zonal SST advection. In the mature phase of ENSO, however, the equatorial thermocline depth anomalies are reflected in the eastern Pacific and slowly propagate westward off the equator in both hemispheres. As a result, the concavity of the thermocline anomalies near the equator is reversed, i.e., the off-equatorial thermocline depth anomalies become higher than that on the equator for El Niño events and lower for La Niño events. This meridional change of thermocline structure reverses zonal transport rapidly in the central-to-eastern equatorial Pacific, which weakens the ENSO SST anomalies by reversed advection. More importantly, the reversed zonal mass transport weakens the existing zonal tilting of equatorial thermocline and suppresses the thermocline feedback. Both processes are concentrated in the eastern equatorial Pacific and can be effective on subseasonal time scales. These current reversal effects are built-in to the ENSO peak phase and independent of the zonal wind effect on thermocline slope. It functions as an oceanic control on ENSO evolution during both El Niño and La Niña events.

  9. The role of the Indonesian Throughflow in equatorial Pacific thermocline ventilation

    Science.gov (United States)

    Rodgers, Keith B.; Cane, Mark A.; Naik, Naomi H.; Schrag, Daniel P.

    1999-09-01

    The role of the Indonesian Throughflow (ITF) in the thermocline circulation of the low-latitude Pacific Ocean is explored using a high-resolution primitive equation ocean circulation model. Seasonally forced runs for a domain with an open Indonesian passage are compared with seasonally forced runs for a closed Pacific domain. Three cases are considered: one with no throughflow, one with 10 Sv of imposed ITF transport, and one with 20 Sv of ITF transport. Two idealized tracers, one that tags northern component subtropical water and another that tags southern component subtropical water, are used to diagnose the mixing ratio of northern and southern component waters in the equatorial thermocline. It is found that the mixing ratio of north/south component waters in the equatorial thermocline is highly sensitive to whether the model accounts for an ITF. Without an ITF, the source of equatorial undercurrent water is primarily of North Pacific origin, with the ratio of northern to southern component water being approximately 2.75 to 1. The ratio of northern to southern component water in the Equatorial Undercurrent with 10 Sv of ITF is approximately 1.4 to 1, and the ratio with 20 Sv of imposed ITF is 1 to 1.25. Estimates from data suggest a mean mixing ratio of northern to southern component water of less than 1 to 1. Assuming that the mixing ratio changes approximately linearly as the ITF transport varies between 10 and 20 Sv, an approximate balance between northern and southern component water is reached when the ITF transport is approximately 16 Sv. It is also shown that for the isopycnal surfaces within the core of the equatorial undercurrent, a 2°C temperature front exists across the equator in the western equatorial Pacific, beneath the warm pool. The implications of the model results and the temperature data for the heat budget of the equatorial Pacific are considered.

  10. Multiple embryos, multiple nepionts and multiple equatorial layers in Cycloclypeus carpenteri.

    Science.gov (United States)

    Briguglio, Antonino; Kinoshita, Shunichi; Wolfgring, Erik; Hohenegger, Johann

    2016-04-01

    In this study, 17 specimens of Cycloclypeus carpenteri have been analyzed by means of microCT scanning. We used CT scanning technique as it enables the visualization and the quantifications of internal structures of hollow specimens without their destruction. It has been observed that many specimens possessing the natural morphology of this taxon, actually contain multiple embryos (up to 16 in one single specimen) and, in some few cases, multiple nepionts each with its own heterosteginid chambers (up to three separated nepionts). The diameter of each proloculus has been measured, and as a result, they are very variable even within the same specimen, therefore questioning the long known theory that schizonts have smaller proloculi than gamonts and also questioning the fact that proloculi in the same species should all have comparable size. Furthermore, we have observed the presence of additional equatorial planes on several specimens. Such additional planes are always connected to what seems to be the main equatorial plane. Such connections are T-shaped and are located at the junction between two equatorial layers; these junctions are made by a chamberlet, which possesses an unusually higher number of apertures. The connections between equatorial planes are always perfectly synchronized with the relative growth step and the same chamber can be therefore followed along the multiple equatorial planes. Apparently there is a perfect geometric relationship between the creation of additional equatorial planes and the position of the nepionts. Whenever the nepionts are positioned on different planes, additional planes are created and the angle of the nepionts is related to the banding angle of the equatorial planes. The presence of additional planes do not hamper the life of the cell, on the contrary, it seems that the cell is still able to build nicely shaped chamberlets and, after volumetric calculations, it seems all specimens managed to keep their logistic growth

  11. Long wavelength irregularities in the equatorial electrojet

    OpenAIRE

    Kudeki, E.; Farley, D. T.; Fejer, Bela G.

    1982-01-01

    We have used the radar interferometer technique at Jicamarca to study in detail irregularities with wavelengths of a few kilometers generated in the unstable equatorial electrojet plasma during strong type 1 conditions. In-situ rocket observations of the same instability process are discussed in a companion paper. These large scale primary waves travel essentially horizontally and have large amplitudes. The vertical electron drift velocities driven by the horizontal wave electric fields reach...

  12. Propagation of EMIC triggered emissions toward the magnetic equatorial plane

    Science.gov (United States)

    Grison, B.; Santolik, O.; Pickett, J. S.; Omura, Y.; Engebretson, M. J.; Dandouras, I. S.; Masson, A.; Decreau, P.; Cornilleau-Wehrlin, N.

    2011-12-01

    EMIC triggered emissions are observed close to the equatorial plane of the magnetosphere at locations where EMIC waves are commonly observed: close to the plasmapause region and in the dayside magnetosphere close to the magnetopause. Their overall characteristics (frequency with time dispersion, generation mechanism) make those waves the EMIC analogue of rising frequency whistler-mode chorus emissions. In our observations the Poynting flux of these emissions is usually clearly arriving from the equatorial region direction, especially when observations take place at more than 5 degrees of magnetic latitude. Simulations have also confirmed that the conditions of generation by interaction with energetic ions are at a maximum at the magnetic equator (lowest value of the background magnetic field along the field line). However in the Cluster case study presented here the Poynting flux of EMIC triggered emissions is propagating toward the equatorial region. The large angle between the wave vector and the background magnetic field is also unusual for this kind of emission. The rising tone starts just above half of the He+ gyrofrequency (Fhe+) and it disappears close to Fhe+. At the time of detection, the spacecraft magnetic latitude is larger than 10 degrees and L shell is about 4. The propagation sense of the emissions has been established using two independent methods: 1) sense of the parallel component of the Poynting flux for a single spacecraft and 2) timing of the emission detections at each of the four Cluster spacecraft which were in a relatively close configuration. We propose here to discuss this unexpected result considering a reflection of this emission at higher latitude.

  13. Hypervitaminosis D in Guinea Pigs with α-Mannosidosis

    Science.gov (United States)

    Jensen, JanLee A; Brice, Angela K; Bagel, Jessica H; Mexas, Angela M; Yoon, Sea Young; Wolfe, John H

    2013-01-01

    A colony of guinea pigs (n = 9) with α-mannosidosis was fed a pelleted commercial laboratory guinea pig diet. Over 2 mo, all 9 guinea pigs unexpectedly showed anorexia and weight loss (11.7% to 30.0% of baseline weight), and 3 animals demonstrated transient polyuria and polydipsia. Blood chemistry panels in these 3 guinea pigs revealed high-normal total calcium, high-normal phosphate, and high ALP. Urine specific gravity was dilute (1.003, 1.009, 1.013) in the 3 animals tested. Postmortem examination of 7 animals that were euthanized after failing to respond to supportive care revealed renal interstitial fibrosis with tubular mineralization, soft tissue mineralization in multiple organs, hepatic lipidosis, and pneumonia. Analysis of the pelleted diet revealed that it had been formulated with a vitamin D3 content of more than 150 times the normal concentration. Ionized calcium and 25-hydroxyvitamin D values were both high in serum saved from 2 euthanized animals, confirming the diagnosis of hypervitaminosis D. This report discusses the clinical signs, blood chemistry results, and gross and histologic findings of hypervitaminosis D in a colony of guinea pigs. When unexpected signs occur colony-wide, dietary differentials should be investigated at an early time point. PMID:23582422

  14. A guinea pig model of Zika virus infection.

    Science.gov (United States)

    Kumar, Mukesh; Krause, Keeton K; Azouz, Francine; Nakano, Eileen; Nerurkar, Vivek R

    2017-04-11

    Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemic of Zika virus (ZIKV). Here we report that immunocompetent guinea pigs are susceptible to infection by a contemporary American strain of ZIKV. Dunkin-Hartley guinea pigs were inoculated with 10 6 plaque-forming units of ZIKV via subcutaneous route and clinical signs were observed. Viremia, viral load in the tissues, anti-ZIKV neutralizing antibody titer, and protein levels of multiple cytokine and chemokines were analyzed using qRT-PCR, plaque assay, plaque reduction neutralization test (PRNT) and multiplex immunoassay. Upon subcutaneous inoculation with PRVABC59 strain of ZIKV, guinea pigs demonstrated clinical signs of infection characterized by fever, lethargy, hunched back, ruffled fur, and decrease in mobility. ZIKV was detected in the whole blood and serum using qRT-PCR and plaque assay. Anti-ZIKV neutralizing antibody was detected in the infected animals using PRNT. ZIKV infection resulted in a dramatic increase in protein levels of multiple cytokines, chemokines and growth factors in the serum. ZIKV replication was observed in spleen and brain, with the highest viral load in the brain. This data demonstrate that after subcutaneous inoculation, the contemporary ZIKV strain is neurotropic in guinea pigs. The guinea pig model described here recapitulates various clinical features and viral kinetics observed in ZIKV-infected patients, and therefore may serve as a model to study ZIKV pathogenesis, including pregnancy outcomes and for evaluation of vaccines and therapeutics.

  15. High altitude flights in equatorial regions

    Science.gov (United States)

    Redkar, R. T.

    A thorough analysis of balloon flights made from Hyderabad, India (Latitude 17°28'N, Longitude 78°35'E), and other equatorial sites has been made. It has been shown that limited success is expected for flights made from equatorial latitudes with balloons made out of natural colour polyethylene film, since the best known balloon film in the world today viz. Winzen Stratofilm is tested for low temperature brittleness only at -80°C., whereas the tropopause temperatures over equatorial latitudes vary between -80°C and -90°C. The success becomes even more critical when flights are made with heavy payloads and larger balloons particularly at night when in the absence of solar radiation the balloon film becomes more susceptible to low temperature brittle failure. It is recommended that in case of capped balloons longer caps should be used to fully cover the inflated protion of the balloon at the higher level equatorial tropopause. It is also advised that the conditions such as wind shears in the tropopause should be critically studied before launching and a day with the tropopause temperature nearer to -80°C should be chosen. Special care also should be taken while handling the balloon on ground and during launching phase. Properties of Winzen Stratofilm have been critically studied and fresh mandates have been recommended on the basis of limiting values of film stresses which caused balloon failures in the equatorial tropopause. It is also emphasized that the data on such flights is still meagre especially for flights with heavy payloads and larger balloons. It has been also shown that it is safest to use balloons made out of grey coloured film which retains its flexibility with the absorption of solar radiation, the success obtained with such balloons so far being 100%. The drawback, however, is that these balloons cannot be used for night flights. Stratospheric wind regimes over Hyderabad are also discussed with a view to determine the period over which long

  16. No iron fertilization in the equatorial Pacific Ocean during the last ice age.

    Science.gov (United States)

    Costa, K M; McManus, J F; Anderson, R F; Ren, H; Sigman, D M; Winckler, G; Fleisher, M Q; Marcantonio, F; Ravelo, A C

    2016-01-28

    The equatorial Pacific Ocean is one of the major high-nutrient, low-chlorophyll regions in the global ocean. In such regions, the consumption of the available macro-nutrients such as nitrate and phosphate is thought to be limited in part by the low abundance of the critical micro-nutrient iron. Greater atmospheric dust deposition could have fertilized the equatorial Pacific with iron during the last ice age--the Last Glacial Period (LGP)--but the effect of increased ice-age dust fluxes on primary productivity in the equatorial Pacific remains uncertain. Here we present meridional transects of dust (derived from the (232)Th proxy), phytoplankton productivity (using opal, (231)Pa/(230)Th and excess Ba), and the degree of nitrate consumption (using foraminifera-bound δ(15)N) from six cores in the central equatorial Pacific for the Holocene (0-10,000 years ago) and the LGP (17,000-27,000 years ago). We find that, although dust deposition in the central equatorial Pacific was two to three times greater in the LGP than in the Holocene, productivity was the same or lower, and the degree of nitrate consumption was the same. These biogeochemical findings suggest that the relatively greater ice-age dust fluxes were not large enough to provide substantial iron fertilization to the central equatorial Pacific. This may have been because the absolute rate of dust deposition in the LGP (although greater than the Holocene rate) was very low. The lower productivity coupled with unchanged nitrate consumption suggests that the subsurface major nutrient concentrations were lower in the central equatorial Pacific during the LGP. As these nutrients are today dominantly sourced from the Subantarctic Zone of the Southern Ocean, we propose that the central equatorial Pacific data are consistent with more nutrient consumption in the Subantarctic Zone, possibly owing to iron fertilization as a result of higher absolute dust fluxes in this region. Thus, ice-age iron fertilization in the

  17. Molecular cloning, expression, and in silico structural analysis of guinea pig IL-17.

    Science.gov (United States)

    Dirisala, Vijaya R; Jeevan, Amminikutty; Ramasamy, Suresh K; McMurray, David N

    2013-11-01

    Interleukin-17A (IL-17A) is a potent proinflammatory cytokine and the signature cytokine of Th17 cells, a subset which is involved in cytokine and chemokine production, neutrophil recruitment, promotion of T cell priming, and antibody production. IL-17 may play an important role in tuberculosis and other infectious diseases. In preparation for investigating its role in the highly relevant guinea pig model of pulmonary tuberculosis, we cloned guinea pig IL-17A for the first time. The complete coding sequence of the guinea pig IL-17A gene (477 nucleotides; 159 amino acids) was subcloned into a prokaryotic expression vector (pET-30a) resulting in the expression of a 17 kDa recombinant guinea pig IL-17A protein which was confirmed by mass spectrometry analysis. Homology modeling of guinea pig IL-17A revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted for this protein showed the presence of one extra helix in the N-terminal region. The expression profile of IL-17A was analyzed quantitatively in spleen, lymph node, and lung cells from BCG-vaccinated guinea pigs by real-time PCR. The guinea pig IL-17A cDNA and its recombinant protein will serve as valuable tools for molecular and immunological studies in the guinea pig model of pulmonary TB and other human diseases.

  18. Molecular cloning and expression of the calmodulin gene from guinea pig hearts.

    Science.gov (United States)

    Feng, Rui; Liu, Yan; Sun, Xuefei; Wang, Yan; Hu, Huiyuan; Guo, Feng; Zhao, Jinsheng; Hao, Liying

    2015-06-01

    The aim of the present study was to isolate and characterize a complementary DNA (cDNA) clone encoding the calmodulin (CaM; GenBank accession no. FJ012165) gene from guinea pig hearts. The CaM gene was amplified from cDNA collected from guinea pig hearts and inserted into a pGEM®-T Easy vector. Subsequently, CaM nucleotide and protein sequence similarity analysis was conducted between guinea pigs and other species. In addition, reverse transcription-polymerase chain reaction (RT-PCR) was performed to investigate the CaM 3 expression patterns in different guinea pig tissues. Sequence analysis revealed that the CaM gene isolated from the guinea pig heart had ∼90% sequence identity with the CaM 3 genes in humans, mice and rats. Furthermore, the deduced peptide sequences of CaM 3 in the guinea pig showed 100% homology to the CaM proteins from other species. In addition, the RT-PCR results indicated that CaM 3 was widely and differentially expressed in guinea pigs. In conclusion, the current study provided valuable information with regard to the cloning and expression of CaM 3 in guinea pig hearts. These findings may be helpful for understanding the function of CaM3 and the possible role of CaM3 in cardiovascular diseases.

  19. Spatial and temporal variability in nutrients and carbon uptake during 2004 and 2005 in the eastern equatorial Pacific Ocean

    DEFF Research Database (Denmark)

    Palacz, A. P.; Chai, F.

    2012-01-01

    The eastern equatorial Pacific plays a great role in the global carbon budget due to its enhanced biological productivity linked to the equatorial upwelling. However, as confirmed by the Equatorial Biocomplexity cruises in 2004 and 2005, nutrient upwelling supply varies strongly, partly due...... and intraseasonal time scales. Here, high resolution Pacific ROMS-CoSiNE (Regional Ocean Modeling System-Carbon, Silicon, Nitrogen Ecosystem) model results were evaluated with in situ and remote sensing data. The results of model-data comparison revealed a good agreement in domain-average hydrographic....... In order to fully resolve the complexity of biological and physical interactions in the eastern equatorial Pacific, we recommended improving CoSiNE and other models by introducing more phytoplankton groups, variable Redfield and carbon to chlorophyll ratios, as well as resolving the Fe-Si co...

  20. Equatorial Geodesics Around the Magnetars

    Science.gov (United States)

    Alfradique, Viviane A. P.; Troconis, Orlenys N.; Negreiros, Rodrigo P.

    Neutron stars manifest themselves as different classes of astrophysical sources that are associated to distinct phenomenology. Here we focus our attention on magnetars (or strongly magnetized neutron stars) that are associated to Soft Gamma Repeaters and Anomalous X-ray Pulsars. The magnetic field on surface of these objects, reaches values greater than 1015 G. Under intense magnetic fields, relativistic effects begin to be decisive for the definition of the structure and evolution of these objects. We are tempted to question ourselves to how strengths fields affect the structure of neutron star. In this work, our objective is study and compare two solutions of Einstein-Maxwell equations: the Bonnor solution, which is an analytical solution that describe the exterior spacetime for a massive compact object which has a magnetic field that is characterize as a dipole field and a complete solution that describe the interior and exterior spacetime for the same source found by numerical methods). For this, we describe the geodesic equations generated by such solutions. Our results show that the orbits generated by the Bonnor solution are the same as described by numerical solution. Also, show that the inclusion of magnetic fields with values up to 1017G in the center of the star does not modify sharply the particle orbits described around this star, so the use of Schwarzschild solution for the description of these orbits is a reasonable approximation.

  1. [Analysis of the main components of inner ear antigens inducing autoimmune Meniere's disease in guinea pigs].

    Science.gov (United States)

    Lu, Ling; Tan, Chang-Qiang; Cui, Yu-Gui; Ding, Gui-Peng; Ju, Xiao-Bin; Li, Yu-Jin; Cai, Wen-Jun

    2008-08-01

    To investigate the main components of inner ear antigens inducing autoimmune Meniere's disease (AIMD) in guinea pigs. The guinea pigs were immunized with isologous crude inner ear antigens (ICIEAg). Then, the hearing function was measured with auditory brainstem response (ABR), the vestibular function was measured with electronystagmography (including spontaneous nystagmus and caloric test), and inner ear histopathological changes were observed by inner ear celloidin section with haematoxylin-eosin staining and observed under light microscope. According to these results, the AIMD-model animals from non-AIMD-model ones were distinguished. The special antibodies against ICIEAg in sera were measured with ELISA. The antigen-antibody reactions against different components of ICIEAg were detected by Western blotting with sera of AIMD and non-AIMD guinea pigs respectively. Then, we analysed the contrast between them and found the main components of the ICIEAg that were positive reaction in AIMD guinea pigs and negative reaction in non-AIMD guinea pigs. The result of ELISA demonstrated that the sera of both the AIMD and non-AIMD guniea pigs contained the special antibodies against ICIEAg after immunized with ICIEAg. The difference of the amount of antibody against ICIEAg between AIMD guinea pig group and non-AIMD guinea pig group was not significant. Western blotting assay showed only the sera of AIMD guinea pig contained the antibodies against the specific antigens with the molecular of 68 000, 58 000, 42 000 and 28 000. ICIEAg contain many different components, the AIMD might only happen in the guinea pigs in which the special immunization against the main components that could induce this kind of disorder appeared. The inner ear antigens with molecular of 68 000, 58 000, 42 000 and 28 000 might be the main components inducing AIMD in guinea pigs.

  2. Nonlinear Rayleigh-Taylor instability in partially ionized plasma and the equatorial spread - F

    International Nuclear Information System (INIS)

    Jain, R.K.; Das, A.C.

    1978-01-01

    The nonlinear evolution of the collisional gravitation induced Rayleigh-Taylor (R-T) instability in the equatorial F region is investigated taking into account the finite Larmor radius (FLR) effects and the complete ion inertial term in ion equation of motion. A special class of coherent weakly nonlinear modes as solutions to the wave equation describing R-T instability driven modes is obtained. The leading nonlinear effects in the wave equation are found to appear through Vsub(L), the ion diamagnetic drift which essentially gives the FLR corrections. It is shown that the R-T modes in the equatorial F region can evolve into coherent, nonlinear, almost sinusoidal, stationary wave structures. These structures are found to travel with a constant phase velocity and to have slightly distorted sinusoidal shapes. These results seem to have a good agreement with many of the recent rocket and satellite observations of the equatorial spread F irregularities. (author)

  3. Anthropogenic 236U recorded in annually banded coral skeleton at Majuro atoll, the equatorial Pacific

    International Nuclear Information System (INIS)

    Sakaguchi, Aya; Eto, Asuka; Takahashi, Yoshio; Steier, Peter; Yamazaki, Atsuko; Watanabe, Tsuyoshi; Sasaki, Keiichi; Yamano, Hiroya

    2013-01-01

    Historical 236 U/ 238 U atom ratio and concentration of 236 U were determined by Accelerator Mass Spectrometry (AMS) in skeletons of dated modern coral core sample collected from Majuro atoll, equatorial Pacific, to reconstruct anthropogenic 236 U inputs to the Equatorial Pacific. The maximum hydrogen bomb-pulses of 236 U/ 238 U and 236 U concentration, 2.83x10 -9 and 1.85x10 7 atom/g, in an annually resolved coral core were captured in 1954 (Operation Castle at Bikini and Enewetok atolls). The values were abruptly decreased in a few years, and they have been gradually decreased over time. Our results allow studies of not only the present distribution pattern, but gives access to the temporal evolution of 236 U in surface seawater of North Equatorial Current which is introduced to the Japan Sea and the North West Pacific Ocean as Kuroshio and Tsushima currents over the past decades. (author)

  4. Larger CO2 source at the equatorial Pacific during the last deglaciation

    Science.gov (United States)

    Kubota, Kaoru; Yokoyama, Yusuke; Ishikawa, Tsuyoshi; Obrochta, Stephen; Suzuki, Atsushi

    2014-01-01

    While biogeochemical and physical processes in the Southern Ocean are thought to be central to atmospheric CO2 rise during the last deglaciation, the role of the equatorial Pacific, where the largest CO2 source exists at present, remains largely unconstrained. Here we present seawater pH and pCO2 variations from fossil Porites corals in the mid equatorial Pacific offshore Tahiti based on a newly calibrated boron isotope paleo-pH proxy. Our new data, together with recalibrated existing data, indicate that a significant pCO2 increase (pH decrease), accompanied by anomalously large marine 14C reservoir ages, occurred following not only the Younger Dryas, but also Heinrich Stadial 1. These findings indicate an expanded zone of equatorial upwelling and resultant CO2 emission, which may be derived from higher subsurface dissolved inorganic carbon concentration. PMID:24918354

  5. Sensitivity of equatorial Pacific and Indian Ocean watermasses to the position of the Indonesian Throughflow

    Science.gov (United States)

    Rodgers, Keith B.; Latif, Mojib; Legutke, Stephanie

    2000-09-01

    The sensitivity of the thermal structure of the equatorial Pacific and Indian Ocean pycnoclines to a model's representation of the Indonesian Straits connecting the two basins is investigated. Two integrations are performed using the global HOPE ocean model. The initial conditions and surface forcing for both cases are identical; the only difference between the runs is that one has an opening for the Indonesian Straits which spans the equator on the Pacific side, and the other has an opening which lies fully north of the equator. The resulting sensitivity throughout much of the upper ocean is greater than 0.5°C for both the equatorial Indian and Pacific. A realistic simulation of net Indonesian Throughflow (ITF) transport (measured in Sverdrups) is not sufficient for an adequate simulation of equatorial watermasses. The ITF must also contain a realistic admixture of northern and southern Pacific source water.

  6. Geomagnetic storms and electric fields in the equatorial ionosphere

    International Nuclear Information System (INIS)

    Rastogi, R.G.

    1977-01-01

    Using direct measurements of equatorial electric field during a geomagnetic storm it is shown that the large decrease in the field observed near the dip equator is due to the reversal of the equatorial electrojet current. This is caused by the imposition of an additional westward electric field on the equatorial ionosphere which was originated by the interaction of solar wind with the interplanetary magnetic field. (author)

  7. Collisional Rayleigh-Taylor instability and shear-flow in equatorial Spread-F plasma

    Directory of Open Access Journals (Sweden)

    N. Chakrabarti

    2003-05-01

    Full Text Available Collisional Rayleigh-Taylor (RT instability is considered in the bottom side of the equatorial F-region. By a novel nonmodal calculation it is shown that for an applied shear flow in equilibrium, the growth of the instability is considerably reduced. Finite but small amounts of diffusion enhances the stabilization process. The results may be relevant to the observations of long-lived irregularities at the bottom-side of the F-layer.Key words. Ionosphere (ionospheric irregularities, equatorial ionosphere, plasma waves and instabilities

  8. MACSAT - A Near Equatorial Earth Observation Mission

    Science.gov (United States)

    Kim, B. J.; Park, S.; Kim, E.-E.; Park, W.; Chang, H.; Seon, J.

    MACSAT mission was initiated by Malaysia to launch a high-resolution remote sensing satellite into Near Equatorial Orbit (NEO). Due to its geographical location, Malaysia can have large benefits from NEO satellite operation. From the baseline circular orbit of 685 km altitude with 7 degrees of inclination, the neighboring regions around Malaysian territory can be frequently monitored. The equatorial environment around the globe can also be regularly observed with unique revisit characteristics. The primary mission objective of MACSAT program is to develop and validate technologies for a near equatorial orbit remote sensing satellite system. MACSAT is optimally designed to accommodate an electro-optic Earth observation payload, Medium-sized Aperture Camera (MAC). Malaysian and Korean joint engineering teams are formed for the effective implementation of the satellite system. An integrated team approach is adopted for the joint development for MACSAT. MAC is a pushbroom type camera with 2.5 m of Ground Sampling Distance (GSD) in panchromatic band and 5 m of GSD in four multi-spectral bands. The satellite platform is a mini-class satellite. Including MAC payload, the satellite weighs under 200 kg. Spacecraft bus is designed optimally to support payload operations during 3 years of mission life. The payload has 20 km of swath width with +/- 30 o of tilting capability. 32 Gbits of solid state recorder is implemented as the mass image storage. The ground element is an integrated ground station for mission control and payload operation. It is equipped with S- band up/down link for commanding and telemetry reception as well as 30 Mbps class X-band down link for image reception and processing. The MACSAT system is capable of generating 1:25,000-scale image maps. It is also anticipated to have capability for cross-track stereo imaging for Digital elevation Model (DEM) generation.

  9. The equatorial F-layer: progress and puzzles

    Directory of Open Access Journals (Sweden)

    H. Rishbeth

    Full Text Available This work reviews some aspects of the ionospheric F-layer in the vicinity of the geomagnetic equator. Starting with a historical introduction, brief summaries are given of the physics that makes the equatorial ionosphere so interesting, concentrating on the large-scale structure rather than the smaller-scale instability phenomena. Several individual topics are then discussed, including eclipse effects, the asymmetries of the `equatorial trough', variations with longitude, the semiannual variation, the effects of the global thermospheric circulation, and finally the equatorial neutral thermosphere, including `superrotation' and possible topographic influences.

    Keyword: Ionosphere (equatorial ionosphere

  10. The Plasma Environment Associated With Equatorial Ionospheric Irregularities

    Science.gov (United States)

    Smith, Jonathon M.; Heelis, R. A.

    2018-02-01

    We examine the density structure of equatorial depletions referred to here as equatorial plasma bubbles (EPBs). Data recorded by the Ion Velocity Meter as part of the Coupled Ion Neutral Dynamics Investigation (CINDI) aboard the Communication/Navigation Outage Forecasting System (C/NOFS) satellite are used to study EPBs from 1600 to 0600 h local time at altitudes from 350 to 850 km. The data are taken during the 7 years from 2008 to 2014, more than one half of a magnetic solar cycle, that include solar minimum and a moderate solar maximum. Using a rolling ball algorithm, EPBs are identified by profiles in the plasma density, each having a depth measured as the percent change between the background and minimum density (ΔN/N). During solar moderate activity bubbles observed in the topside postsunset sector are more likely to have large depths compared to those observed in the topside postmidnight sector. Large bubble depths can be observed near 350 km in the bottomside F region in the postsunset period. Conversely at solar minimum the distribution of depths is similar in the postsunset and postmidnight sectors in all longitude sectors. Deep bubbles are rarely observed in the topside postsunset sector and never in the bottomside above 400 km in altitude. We suggest that these features result from the vertical drift of the plasma for these two solar activity levels. These drift conditions affect both the background density in which bubbles are embedded and the growth rate of perturbations in the bottomside where bubbles originate.

  11. Guinea Worm in a Frog

    Centers for Disease Control (CDC) Podcasts

    2017-03-09

    Dr. Mark Eberhard, a retired parasitologist and CDC guest researcher, discusses Guinea worm infection in a wild-caught frog.  Created: 3/9/2017 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 3/9/2017.

  12. Guinea pig ID-like families of SINEs.

    Science.gov (United States)

    Kass, David H; Schaetz, Brian A; Beitler, Lindsey; Bonney, Kevin M; Jamison, Nicole; Wiesner, Cathy

    2009-05-01

    Previous studies have indicated a paucity of SINEs within the genomes of the guinea pig and nutria, representatives of the Hystricognathi suborder of rodents. More recent work has shown that the guinea pig genome contains a large number of B1 elements, expanding to various levels among different rodents. In this work we utilized A-B PCR and screened GenBank with sequences from isolated clones to identify potentially uncharacterized SINEs within the guinea pig genome, and identified numerous sequences with a high degree of similarity (>92%) specific to the guinea pig. The presence of A-tails and flanking direct repeats associated with these sequences supported the identification of a full-length SINE, with a consensus sequence notably distinct from other rodent SINEs. Although most similar to the ID SINE, it clearly was not derived from the known ID master gene (BC1), hence we refer to this element as guinea pig ID-like (GPIDL). Using the consensus to screen the guinea pig genomic database (Assembly CavPor2) with Ensembl BlastView, we estimated at least 100,000 copies, which contrasts markedly to just over 100 copies of ID elements. Additionally we provided evidence of recent integrations of GPIDL as two of seven analyzed conserved GPIDL-containing loci demonstrated presence/absence variants in Cavia porcellus and C. aperea. Using intra-IDL PCR and sequence analyses we also provide evidence that GPIDL is derived from a hystricognath-specific SINE family. These results demonstrate that this SINE family continues to contribute to the dynamics of genomes of hystricognath rodents.

  13. Preliminary report: STOIC CGCM intercomparison - equatorial sections

    International Nuclear Information System (INIS)

    Davey, M; Huddleston, M; Sperber, K R.

    1999-01-01

    An intercomparison and assessment of the tropical behaviour of coupled general circulation models (CGCMs) is being carried out, to identify common strengths and weaknesses and thus guide future CGCM development. The work is being carried out as part of the CLIVAR climate research programme, as a WG-SIP (Working Group on Seasonal to Interannual Prediction) project called STOIC (Study of Tropical Oceans In CGCMs), organised by Michael Davey. This project complements a companion sub-project called ENSIP (El Ni no Simulation Intercomparison Project) organised by Mojib Latif (Max- Planck-Institute for Meteorology) that focusses on equatorial Pacific CGCM behaviour (Latif et al. 1999). Previous coupled model assessments (Mechoso et al. 1995, Neelin et al. 1992, and ENSIP) have focussed on tropical Pacific behaviour. The aim of STOIC is to look at model performance in all tropical ocean regions. This status report contains a sample of the STOIC assessment work, highlighting mean and inter- annual equatorial sea surface temperatures and zonal windstresses. The intention is to submit STOIC and ENSIP papers in mid-1999 for publication together in a refereed journal

  14. Nighttime ionospheric D region: Equatorial and nonequatorial

    Science.gov (United States)

    Thomson, Neil R.; McRae, Wayne M.

    2009-08-01

    Nighttime ionospheric D region parameters are found to be generally well modeled by the traditional H‧ and β as used by Wait and by the U.S. Navy in their Earth-ionosphere VLF radio waveguide programs. New comparisons with nonequatorial, mainly all-sea VLF path observations reported over several decades are shown to be consistent with the previously determined height H‧ ˜ 85.0 km and sharpness β ˜ 0.63 km-1. These paths include NPM (Hawaii) to Washington, D. C., Omega Hawaii and NLK (Seattle) to Japan, NWC (N.W. Australia) to Madagascar, and NBA (Panama) to Colorado. In marked contrast, transequatorial path observations (even when nearly all-sea) are found to be often not well modeled: for example, for Omega Japan and JJI (Japan) to Dunedin, New Zealand, the observed amplitudes are markedly lower than those which would be expected from H‧ ˜ 85.0 km and β ˜ 0.63 km-1, or any other realistic values of H‧ and β. Other transequatorial observations compared with modeling include NWC to Japan, Omega Hawaii to Dunedin, and NPM (Hawaii) to Dunedin. It is suggested that the effects of irregularities in the equatorial electrojet may extend down into the nighttime D region and so account for the observed equatorial VLF perturbations through scattering or mode conversion.

  15. Midday reversal of equatorial ionospheric electric field

    Directory of Open Access Journals (Sweden)

    R. G. Rastogi

    1997-10-01

    Full Text Available A comparative study of the geomagnetic and ionospheric data at equatorial and low-latitude stations in India over the 20 year period 1956–1975 is described. The reversal of the electric field in the ionosphere over the magnetic equator during the midday hours indicated by the disappearance of the equatorial sporadic E region echoes on the ionograms is a rare phenomenon occurring on about 1% of time. Most of these events are associated with geomagnetically active periods. By comparing the simultaneous geomagnetic H field at Kodaikanal and at Alibag during the geomagnetic storms it is shown that ring current decreases are observed at both stations. However, an additional westward electric field is superimposed in the ionosphere during the main phase of the storm which can be strong enough to temporarily reverse the normally eastward electric field in the dayside ionosphere. It is suggested that these electric fields associated with the V×Bz electric fields originate at the magnetopause due to the interaction of the solar wind and the interplanetary magnetic field.

  16. Central Equatorial Pacific Experiment (CEPEX). Design document

    Energy Technology Data Exchange (ETDEWEB)

    1993-04-01

    The Earth`s climate has varied significantly in the past, yet climate records reveal that in the tropics, sea surface temperatures seem to have been remarkably stable, varying by less than a few degrees Celsius over geologic time. Today, the large warm pool of the western Pacific shows similar characteristics. Its surface temperature always exceeds 27{degree}C, but never 31{degree}C. Heightened interest in this observation has been stimulated by questions of global climate change and the exploration of stabilizing climate feedback processes. Efforts to understand the observed weak sensitivity of tropical sea surface temperatures to climate forcing has led to a number of competing ideas about the nature of this apparent thermostat. Although there remains disagreement on the processes that regulate tropical sea surface temperature, most agree that further progress in resolving these differences requires comprehensive field observations of three-dimensional water vapor concentrations, solar and infrared radiative fluxes, surface fluxes of heat and water vapor, and cloud microphysical properties. This document describes the Central Equatorial Pacific Experiment (CEPEX) plan to collect such observations over the central equatorial Pacific Ocean during March of 1993.

  17. Midday reversal of equatorial ionospheric electric field

    Directory of Open Access Journals (Sweden)

    R. G. Rastogi

    Full Text Available A comparative study of the geomagnetic and ionospheric data at equatorial and low-latitude stations in India over the 20 year period 1956–1975 is described. The reversal of the electric field in the ionosphere over the magnetic equator during the midday hours indicated by the disappearance of the equatorial sporadic E region echoes on the ionograms is a rare phenomenon occurring on about 1% of time. Most of these events are associated with geomagnetically active periods. By comparing the simultaneous geomagnetic H field at Kodaikanal and at Alibag during the geomagnetic storms it is shown that ring current decreases are observed at both stations. However, an additional westward electric field is superimposed in the ionosphere during the main phase of the storm which can be strong enough to temporarily reverse the normally eastward electric field in the dayside ionosphere. It is suggested that these electric fields associated with the V×Bz electric fields originate at the magnetopause due to the interaction of the solar wind and the interplanetary magnetic field.

  18. Molecular cloning, sequence identification and expression profile of domestic guinea pig (Cavia porcellus UGT1A1 gene

    Directory of Open Access Journals (Sweden)

    Yang Deming

    2016-01-01

    Full Text Available Domestic guinea pig is a model animal for human disease research. Uridine diphosphate glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1 is an important human disease-related gene. In this study, the complete coding sequence of domestic guinea pig gene UGT1A1 was amplified by reverse transcription-polymerase chain reaction. The open reading frame of the domestic guinea pig UGT1A1 gene is 1602 bp in length and was found to encode a protein of 533 amino acids. Sequence analysis revealed that the UGT1A1 protein of domestic guinea pig shared high homology with the UGT1A1 proteins of degu (84%, damara mole-rat (84%, human (80%, northern white-cheeked gibbon (80%, Colobus angolensis palliatus (80% and golden snub-nosed monkey (79%. This gene contains five exons and four introns, as revealed by the computer-assisted analysis. The results also showed that the domestic guinea pig UGT1A1 gene had a close genetic relationship with the UGT1A1 gene of degu. The prediction of transmembrane helices showed that domestic guinea pig UGT1A1 might be a transmembrane protein. Expression profile analysis indicated that the domestic guinea pig UGT1A1 gene was differentially expressed in detected domestic guinea pig tissues. Our experiment laid a primary foundation for using the domestic guinea pig as a model animal to study the UGT1A1-related human diseases.

  19. A reliable method for reconstituting thymectomized, lethally irradiated guinea pigs with bone marrow cells

    International Nuclear Information System (INIS)

    Terata, N.; Tanio, Y.; Zbar, B.

    1984-01-01

    The authors developed a reliable method for reconstituting thymectomized, lethally irradiated guinea pigs. Injection of 2.5-10 x 10 7 syngeneic bone marrow cells into adult thymectomized, lethally irradiated guinea pigs produced survival of 46-100% of treated animals. Gentamycin sulfate (5 mg/kg of body weight) for 10 days was required for optimal results. Acidified drinking water (pH 2.5) appeared to be required for optimal results. Thymectomized, lethally irradiated, bone marrow reconstituted ('B') guinea pigs had impaired ability to develop delayed cutaneous hypersensitivity to mycobacterial antigens and cutaneous basophil hypersensitivity to keyhole limpet hemocyanin; proliferative responses to phytohemagglutinin were impaired. (Auth.)

  20. Deep currents in the Gulf of Guinea: along slope propagation of intraseasonal waves

    Directory of Open Access Journals (Sweden)

    C. Guiavarc'h

    2009-05-01

    Full Text Available In the Gulf of Guinea, intraseasonal variability is large at the equator and along the coast. Current data on the continental slope near 7.5° S show very energetic biweekly oscillations at 1300 m depth. A high resolution primitive equation numerical model demonstrates that this deep variability is forced by equatorial winds, through the generation of equatorial Yanai waves that propagate eastward and at depth, and then poleward as coastally-trapped waves upon reaching the coast of Africa. Intraseasonal variability is intensified along the coast of the Gulf of Guinea, especially in the 10–20 day period range and at depths between 500 and 1500 m. The kinetic energy distribution is well explained at first order by linear theory. Along the equator, eastward intensification of energy and bottom intensification are in qualitative agreement with vertically propagating Yanai waves, although the signal is influenced by the details of the bathymetry. Along the coast, baroclinic modes 3 to 5 are important close to the equator, and the signal is dominated by lower vertical modes farther south. Additional current meter data on the continental slope near 3° N display an energy profile in the 10–20 day period band that is strikingly different from the one at 7.5° S, with surface intensification rather than bottom intensification and a secondary maximum near 800 m. The model reproduces these features and explains them: the surface intensification in the north is due to the regional wind forcing, and the north-south asymmetry of the deep signal is due to the presence of the zonal African coast near 5° N. A 4 years time series of current measurements at 7.5° S shows that the biweekly oscillations are intermittent and vary from year to year. This intermittency is not well correlated with fluctuations of the equatorial winds and does not seem to be a simple linear response to the wind forcing.

  1. Molecular cloning and expression of the IL-10 gene from guinea pigs.

    Science.gov (United States)

    Dirisala, Vijaya R; Jeevan, Amminikutty; Bix, Gregory; Yoshimura, Teizo; McMurray, David N

    2012-04-25

    The Guinea pig (Cavia porcellus) is one of the most relevant small animals for modeling human tuberculosis (TB) in terms of susceptibility to low dose aerosol infection, the organization of granulomas, extrapulmonary dissemination and vaccine-induced protection. It is also considered to be a gold standard for a number of other infectious and non-infectious diseases; however, this animal model has a major disadvantage due to the lack of readily available immunological reagents. In the present study, we successfully cloned a cDNA for the critical Th2 cytokine, interleukin-10 (IL-10), from inbred Strain 2 guinea pigs using the DNA sequence information provided by the genome project. The complete open reading frame (ORF) consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10. Surprisingly, it showed only 84% homology with the previously published IL-10 sequence from the C4-deficient (C4D) guinea pig, leading us to clone IL-10 cDNA from the Hartley strain of guinea pig. The IL-10 gene from the Hartley strain showed 100% homology with the IL-10 sequence of Strain 2 guinea pigs. In order to validate the only published IL-10 sequence existing in Genbank reported from C4D guinea pigs, genomic DNA was isolated from tissues of C4D guinea pigs. Amplification with various sets of primers showed that the IL-10 sequence reported from C4D guinea pigs contained numerous errors. Hence the IL-10 sequence that is being reported by us replaces the earlier sequence making our IL-10 sequence to be the first one accurate from guinea pig. Recombinant guinea pig IL-10 proteins were subsequently expressed in both prokaryotic and eukaryotic cells, purified and were confirmed by N-terminal sequencing. Polyclonal anti-IL-10 antibodies were generated in rabbits using the recombinant IL-10 protein expressed in this study. Taken together, our results indicate that the DNA sequence information provided by the genome project

  2. Temperature Preference in IAF Hairless and Hartley Guinea Pigs (Cavia porcellus).

    Science.gov (United States)

    Kleven, Gale A; Joshi, Prianca

    2016-03-01

    The Hairless strain of guinea pigs (Cavia porcellus) is the result of a spontaneous recessive mutation first identified at the Institute Armand Frappier (IAF) in 1978. Despite the longstanding availability of this strain, little is known about its thermoregulatory behavior. The aim of this study was to determine temperature preference in Hartley and Hairless guinea pigs by observing each strain in a ring-shaped apparatus containing a nonlinear temperature gradient. Temperatures were maintained by separately controlled heating mats lining the apparatus. Set point temperatures ranged from 24 to 38 °C. Guinea pigs (Hartley female, Hairless female, and Hairless male guinea pigs; n = 8 each group) were placed either singly or in pairs at 1 of the 8 randomized starting points within the apparatus. Subjects were observed for 30 min and coded for location within the temperature gradient by both frequency and duration. When placed singly in the apparatus, all 3 groups spent more time in the 30 °C zones. However, when placed as pairs with a cagemate, Hartley female guinea pigs spent more time in the cooler range of temperatures from 24 to 30 °C, whereas Hairless guinea pigs preferred a range of 30 to 38 °C. These results confirm a temperature preference of 30 ± 2 °C for both Hartley and Hairless guinea pigs when singly housed. However, data from the paired housing condition suggest that context plays an important role in thermoregulatory behavior.

  3. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).

    Science.gov (United States)

    Henao-Restrepo, Ana Maria; Camacho, Anton; Longini, Ira M; Watson, Conall H; Edmunds, W John; Egger, Matthias; Carroll, Miles W; Dean, Natalie E; Diatta, Ibrahima; Doumbia, Moussa; Draguez, Bertrand; Duraffour, Sophie; Enwere, Godwin; Grais, Rebecca; Gunther, Stephan; Gsell, Pierre-Stéphane; Hossmann, Stefanie; Watle, Sara Viksmoen; Kondé, Mandy Kader; Kéïta, Sakoba; Kone, Souleymane; Kuisma, Eewa; Levine, Myron M; Mandal, Sema; Mauget, Thomas; Norheim, Gunnstein; Riveros, Ximena; Soumah, Aboubacar; Trelle, Sven; Vicari, Andrea S; Røttingen, John-Arne; Kieny, Marie-Paule

    2017-02-04

    rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed cases in Guinea, west Africa. We did an open-label, cluster-randomised ring vaccination trial (Ebola ça Suffit!) in the communities of Conakry and eight surrounding prefectures in the Basse-Guinée region of Guinea, and in Tomkolili and Bombali in Sierra Leone. We assessed the efficacy of a single intramuscular dose of rVSV-ZEBOV (2×10 7 plaque-forming units administered in the deltoid muscle) in the prevention of laboratory confirmed Ebola virus disease. After confirmation of a case of Ebola virus disease, we definitively enumerated on a list a ring (cluster) of all their contacts and contacts of contacts including named contacts and contacts of contacts who were absent at the time of the trial team visit. The list was archived, then we randomly assigned clusters (1:1) to either immediate vaccination or delayed vaccination (21 days later) of all eligible individuals (eg, those aged ≥18 years and not pregnant, breastfeeding, or severely ill). An independent statistician generated the assignment sequence using block randomisation with randomly varying blocks, stratified by location (urban vs rural) and size of rings (≤20 individuals vs >20 individuals). Ebola response teams and laboratory workers were unaware of assignments. After a recommendation by an independent data and safety monitoring board, randomisation was stopped and immediate vaccination was also offered to children aged 6-17 years and all identified rings. The prespecified primary outcome was a laboratory confirmed case of Ebola virus disease with onset 10 days or more from randomisation. The primary analysis compared the incidence of Ebola virus disease in eligible and vaccinated individuals assigned to immediate

  4. The D1 parameter for the equatorial F1 region

    International Nuclear Information System (INIS)

    Adeniyi, J.O.; Radicella, S.M.

    2002-01-01

    This work is a contribution to the effort at improving the representation of the F1 equatorial ionospheric region in the International Reference Ionosphere (IRI) model. The D1 parameter has been proposed for describing the F1 layer. We have therefore produced a maiden table of D1 parameter for an equatorial station. Diurnal and seasonal effects were considered. (author)

  5. Observers in Kerr spacetimes. The ergoregion on the equatorial plane

    Energy Technology Data Exchange (ETDEWEB)

    Pugliese, D. [Silesian University in Opava, Faculty of Philosophy and Science, Institute of Physics, Opava (Czech Republic); Quevedo, H. [Universita di Roma ' ' La Sapienza' ' , Dipartimento di Fisica, Rome (Italy); Universidad Nacional Autonoma de Mexico, Instituto de Ciencias Nucleares, Mexico, DF (Mexico); Kazakh National University, Department of Theoretical and Nuclear Physics, Almaty (Kazakhstan)

    2018-01-15

    We perform a detailed analysis of the properties of stationary observers located on the equatorial plane of the ergosphere in a Kerr spacetime, including light-surfaces. This study highlights crucial differences between black hole and the super-spinner sources. In the case of Kerr naked singularities, the results allow us to distinguish between ''weak'' and ''strong'' singularities, corresponding to spin values close to or distant from the limiting case of extreme black holes, respectively. We derive important limiting angular frequencies for naked singularities. We especially study very weak singularities as resulting from the spin variation of black holes. We also explore the main properties of zero angular momentum observers for different classes of black hole and naked singularity spacetimes. (orig.)

  6. Is there a hole in the topside, equatorial ionosphere?

    Directory of Open Access Journals (Sweden)

    D. Gallagher

    Full Text Available A paper in 2000 (Huba, 2000 found a depression in electron density in the topside ionosphere near the magnetic equator, based on the SAMI-2 physical ionospheric model. The model showed, for the first time, the formation of a hole in electron density in the altitude range 1500–2500 km at geomagnetic equatorial latitudes. The model produced the hole because of transhemispheric O+ flows that collisionally couple to H+, transporting it to lower altitudes, and thereby reducing the electron density at high altitudes. At that time and until now, no published observations have been reported to confirm or refute this numerical result. Recent, new analysis of Dynamics Explorer 1 Retarding Ion Mass Spectrometer measurements provides the first tentative experimental support for this model result. Keywords: Ionosphere, Topside, Magnetic equator, Plasmasphere

  7. Equatorial electrojet and its response to external electromagnetic effects

    Science.gov (United States)

    Bespalov, P. A.; Savina, O. N.

    2012-09-01

    In the quiet low-latitude Earth's ionosphere, a sufficiently developed current system that is responsible for the Sq magnetic-field variations is formed in quiet Sun days under the action of tidal streams. The density of the corresponding currents is maximum in the midday hours at the equatorial latitudes, where the so-called equatorial electrojet is formed. In this work, we discuss the nature of the equatorial electrojet. This paper studies the value of its response to external effects. First of all, it is concerned with estimating the possibility of using the equatorial electrojet for generating low-frequency electromagnetic signals during periodic heating of the ionosphere by the heating-facility radiation. The equatorial electrojet can also produce electrodynamic response to the natural atmospheric processes, e.g., an acoustic-gravity wave.

  8. Prevalence of dermatophytes and other superficial fungal organisms in asymptomatic guinea pigs in Southern Italy.

    Science.gov (United States)

    d'Ovidio, D; Grable, S L; Ferrara, M; Santoro, D

    2014-07-01

    Guinea pigs have been indicated as a potential source of zoophilic dermatophytes that cause human dermatomycosis. The purpose of this study was to evaluate the prevalence of dermatophytes as well as saprophytic fungi in asymptomatic pet guinea pigs in Southern Italy. Two-hundred pet guinea pigs were enrolled from both private veterinary clinics and pet shops in the Campania region, Italy, from August 2012 to September 2013. Samples were collected using the MacKenzie's toothbrush technique. The plates were incubated for four weeks at 25°C and identification of the fungal colonies was based on both macroscopic and microscopic characteristics. Two pathogenic dermatophytes were isolated in 9 (4·5%) of 200 guinea pigs; Epidermophyton species in 2 (1%) and Scopulariopsis species in 7 (3·5%). Saprophytic dermatophytes were isolated from 151 (75·5%) animals enrolled. No fungal growth was observed in 40 (20%) guinea pigs. The results of this study indicate a low prevalence of pathogenic dermatophytes in pet guinea pigs in Southern Italy but the presence of Epidermophyton and Scopulariopsis species in asymptomatic pet guinea pigs. © 2014 British Small Animal Veterinary Association.

  9. The provision of potable water in eradication of Guinea worm infection in Ezza North, Southeastern, Nigeria.

    Science.gov (United States)

    Ede, Alison Okorie; Nwaokoro, Joakin Chidozie; Iwuala, C C; Amadi, A N; Akpelu, Ugochinyere Alvana

    2014-10-01

    Guinea worm is a parasite found in unprotected drinking water sources, causes considerable morbidity and loss of agricultural production among rural people. The study was to determine the current status of Guinea worm infection in Ezza North and to evaluate the impact of control measures on guinea worm infection. A total of 200 individuals in Ezza North Southeastern, Nigeria were examined for guinea worm infection. A standardized questionnaire was used to determine the effect of potable water on guinea worm eradication/control, the source of drinking water, information on the knowledge, attitude, symptom management practices, availability of health facilities and boreholes installation status. The instrument for data collection was well constructed, validated and reliable tested questionnaire by an expert. Data obtained was analyzed using Epi-Info model 3.4 versions. Results of a study indicated majority of the respondents 195 (97.5 %) have access to safe drinking water supply which indicated no case of Guinea worm infection. The active use of potable water supply was found among the age group of 20-30 years 71 (35.5 %) and higher in male (57.5 %) than females (42.5 %). The drastic reduction of Guinea worm infection to zero (0) level in Ezza North were due to multiple factors as health education, availability of functional boreholes, presence of health centers for immediate treatment if any case discovered.

  10. Long wavelength irregularities in the equatorial electrojet

    International Nuclear Information System (INIS)

    Kudeki, E.; Farley, D.T.; Fejer, B.G.

    1982-01-01

    We have used the radar interferometer technique at Jicamarca to study in detail irregularities with wavelengths of a few kilometers generated in the unstable equatorial electrojet plasma during strong type 1 conditions. In-situ rocket observations of the same instability process are discussed in a companion paper. These large scale primary waves travel essentially horizontally and have large amplitudes. The vertical electron drift velocities driven by the horizontal wave electric fields reach or exceed the ion-acoustic velocity even though the horizontal phase velocity of the wave is considerably smaller. A straightforward extension to the long wavelength regime of the usual linear theory of the electrojet instability explains this and several other observed features of these dominant primary waves

  11. Linear theory of equatorial spread F

    International Nuclear Information System (INIS)

    Hudson, M.K.; Kennel, C.F.

    1975-01-01

    A fluid dispersion relation for the drift and interchange (Rayleigh-Taylor) modes in a collisional plasma forms the basis for a linear theory of equatorial spread F. The collisional drift mode growth rate will exceed the growth rate of the Rayleigh-Taylor mode at short perpendicular wavelengths and density gradient scale lengths, and the drift mode can grow on top side as well as on bottom side density gradients. However, below the F peak, where spread F predominates, it is concluded that both the drift and the Rayleigh-Taylor modes contribute to the total spread F spectrum, the Rayleigh-Taylor mode dominating at long and the drift mode at short perpendicular wavelengths above the ion Larmor radius

  12. Equatorial circular motion in Kerr spacetime

    International Nuclear Information System (INIS)

    Pugliese, Daniela; Quevedo, Hernando; Ruffini, Remo

    2011-01-01

    We analyze the properties of circular orbits of test particles on the equatorial plane of a rotating central mass whose gravitational field is described by the Kerr spacetime. For rotating black holes and naked singularities we explore all the spatial regions where circular orbits can exist and analyze the behavior of the energy and the angular momentum of the corresponding test particles. In particular, we find all the radii at which a test particle can have zero angular momentum due to the repulsive gravity effects generated by naked singularities. We classify all the stability zones of circular orbits. It is shown that the geometric structure of the stability zones of black holes is completely different from that of naked singularities.

  13. SULFAMETHOXAZOLE-TRIMETHOPRIM TREATMENT OF GUINEA PIGS INFECTED WITH 'LEGIONELLA PNEUMPOPHILA'

    Science.gov (United States)

    Legionnaires' disease is a bacterial pneumonia caused by Legionella pneumophila. Many antibiotics inhibit the growth of L. pneumophila in vitro, but only erythromycin and rifampin have been clinically effective. Parallel results have been observed in guinea pigs infected ip with ...

  14. A Generalized Equatorial Model for the Accelerating Solar Wind

    Science.gov (United States)

    Tasnim, S.; Cairns, Iver H.; Wheatland, M. S.

    2018-02-01

    A new theoretical model for the solar wind is developed that includes the wind's acceleration, conservation of angular momentum, deviations from corotation, and nonradial velocity and magnetic field components from an inner boundary (corresponding to the onset of the solar wind) to beyond 1 AU. The model uses a solution of the time-steady isothermal equation of motion to describe the acceleration and analytically predicts the Alfvénic critical radius. We fit the model to near-Earth observations of the Wind spacecraft during the solar rotation period of 1-27 August 2010. The resulting data-driven model demonstrates the existence of noncorotating, nonradial flows and fields from the inner boundary (r = rs) outward and predicts the magnetic field B = (Br,Bϕ), velocity v = (vr,vϕ), and density n(r,ϕ,t), which vary with heliocentric distance r, heliolatitude ϕ, and time t in a Sun-centered standard inertial plane. The description applies formally only in the equatorial plane. In a frame corotating with the Sun, the transformed velocity v' and a field B' are not parallel, resulting in an electric field with a component Ez' along the z axis. The resulting E'×B'=E'×B drift lies in the equatorial plane, while the ∇B and curvature drifts are out of the plane. Together these may lead to enhanced scattering/heating of sufficiently energetic particles. The model predicts that deviations δvϕ from corotation at the inner boundary are common, with δvϕ(rs,ϕs,ts) comparable to the transverse velocities due to granulation and supergranulation motions. Abrupt changes in δvϕ(rs,ϕs,ts) are interpreted in terms of converging and diverging flows at the cell boundaries and centers, respectively. Large-scale variations in the predicted angular momentum demonstrate that the solar wind can drive vorticity and turbulence from near the Sun to 1 AU and beyond.

  15. Dynamical variability in Saturn Equatorial Atmosphere

    Science.gov (United States)

    Sánchez-Lavega, A.; Pérez-Hoyos, S.; Hueso, R.; Rojas, J. F.; French, R. G.; Grupo Ciencias Planetarias Team

    2003-05-01

    Historical ground-based and recent HST observations show that Saturn's Equatorial Atmosphere is the region where the most intense large-scale dynamical variability took place at cloud level in the planet. Large-scale convective storms (nicknamed the ``Great White Spots") occurred in 1876, 1933 and 1990. The best studied case (the 1990 storm), produced a dramatic change in the cloud aspect in the years following the outburst of September 1990. Subsequently, a new large storm formed in 1994 and from 1996 to 2002 our HST observations showed periods of unusual cloud activity in the southern part of the Equator. This contrast with the aspect observed during the Voyager 1 and 2 encounters in 1980 and 1981 when the Equator was calm, except for some mid-scale plume-like features seen in 1981. Cloud-tracking of the features have revealed a dramatic slow down in the equatorial winds from maximum velocities of ˜ 475 m/s in 1980-1981 to ˜ 275 m/s during 1996-2002, as we have recently reported in Nature, Vol. 423, 623 (2003). We discuss the possibility that seasonal and ring-shadowing effects are involved in generating this activity and variability. Acknowledgements: This work was supported by the Spanish MCYT PNAYA 2000-0932. SPH acknowledges a PhD fellowship from the Spanish MECD and RH a post-doc fellowship from Gobierno Vasco. RGF was supported in part by NASA's Planetary Geology and Geophysics Program NAG5-10197 and STSCI Grant GO-08660.01A.

  16. Seasonal-longitudinal variability of equatorial plasma bubbles

    Directory of Open Access Journals (Sweden)

    W. J. Burke

    2004-09-01

    Full Text Available We compare seasonal and longitudinal distributions of more than 8300 equatorial plasma bubbles (EPBs observed during a full solar cycle from 1989-2000 with predictions of two simple models. Both models are based on considerations of parameters that influence the linear growth rate, γRT, of the generalized Rayleigh-Taylor instability in the context of finite windows of opportunity available during the prereversal enhancement near sunset. These parameters are the strength of the equatorial magnetic field, Beq, and the angle, α, it makes with the dusk terminator line. The independence of α and Beq from the solar cycle phase justifies our comparisons.

    We have sorted data acquired during more than 75000 equatorial evening-sector passes of polar-orbiting Defense Meteorological Satellite Program (DMSP satellites into 24 longitude and 12 one-month bins, each containing ~250 samples. We show that: (1 in 44 out of 48 month-longitude bins EPB rates are largest within 30 days of when α=0°; (2 unpredicted phase shifts and asymmetries appear in occurrence rates at the two times per year when α≈0°; (3 While EPB occurrence rates vary inversely with Beq, the relationships are very different in regions where Beq is increasing and decreasing with longitude. Results (2 and (3 indicate that systematic forces not considered by the two models can become important. Damping by interhemispheric winds appears to be responsible for phase shifts in maximum rates of EPB occurrence from days when α=0°. Low EPB occurrence rates found at eastern Pacific longitudes suggest that radiation belt electrons in the drift loss cone reduce γRT by enhancing E-layer Pedersen conductances. Finally, we analyze an EPB event observed during a magnetic storm at a time and place where α≈-27°, to illustrate how electric-field penetration from

  17. Pathogenesis of a Chinese strain of bovine adenovirus type 3 infection in albino guinea pigs.

    Science.gov (United States)

    Shi, Hong-Fei; Zhu, Yuan-Mao; Yan, Hao; Ma, Lei; Wang, Xue-Zhi; Xue, Fei

    2014-12-01

    Bovine adenovirus type 3 (BAV-3) is considered one of the most important respiratory tract agents of cattle and is widespread among cattle around the world. A BAV-3 strain was isolated from a bovine nasal swab for the first time in China in 2009 and named HLJ0955. Subsequently, BAV-3 has frequently been isolated from calves with respiratory diseases in China. To date, only limited study on the pathogenesis of BAV-3 infection in cotton rats has been conducted, and the pathogenesis of BAV-3 infection in guinea pigs has not been reported. Therefore, sixteen albino guinea pigs were inoculated intranasally with HLJ0955. All of the infected guinea pigs had apparently elevated rectal temperatures (39.2 °C-39.9 °C) at 2-7 days post-inoculation (PI). Consolidation and petechial hemorrhage were also observed in guinea pigs experimentally infected with HLJ0955. Viral replication was detectable by virus isolation and titration and by immunohistochemistry in the lungs of guinea pigs as early as 24 h PI. Viral DNA was detectable in the lungs of infected guinea pigs during 11 days of observation by real-time PCR. Virus-neutralizing antibodies against BAV-3 were detectable from 11 days PI and reached a peak titer at 15 days PI. Histopathological changes mainly occurred in the lungs of infected guinea pigs and were characterized by thickening of alveolar septa, mononuclear cell infiltration, hemorrhage and alveolar epithelial necrosis. These results indicate that HLJ0955 can replicate in the lungs of guinea pigs and cause fever and gross and histological lesions. The guinea pig infection model of BAV-3 would serve as a useful system for monitoring the infection process and pathogenesis of the Chinese BAV-3 strain HLJ0955, as well as immune responses to BAV-3 vaccines.

  18. Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis

    Science.gov (United States)

    Dharmadhikari, Ashwin S.; Basaraba, Randall J.; Van Der Walt, Martie L.; Weyer, Karin; Mphahlele, Matsie; Venter, Kobus; Jensen, Paul A.; First, Melvin W.; Parsons, Sydney; McMurray, David N.; Orme, Ian M.; Nardell, Edward A.

    2012-01-01

    A natural TB infection model using guinea pigs may provide useful information for investigating differences in transmission efficiency and establishment of active disease by clinical TB strains in a highly susceptible host under controlled environmental conditions. We sought to examine the capacity of naturally transmitted multidrug-resistant M. tuberculosis to establish infection and produce active disease in guinea pigs. Guinea pigs were continuously exposed for 4 months to the exhaust air of a 6-bed multidrug-resistant tuberculosis inpatient hospital ward in South Africa. Serial tuberculin skin test reactions were measured to determine infection. All animals were subsequently evaluated for histologic disease progression at necropsy. Although 75% of the 362 exposed guinea pigs had positive skin test reactions [≥6mm], only 12% had histopathologic evidence of active disease. Reversions (≥ 6 mm change) in skin test reactivity were seen in 22% of animals, exclusively among those with reactions of 6 to 13 mm. Only two of 86 guinea pigs with reversion had histological evidence of disease compared to 47% (31/66) of guinea pigs with large, non-reverting reactions. Immunosuppression of half the guinea pigs across all skin test categories did not significantly accelerate disease progression. In guinea pigs that reverted a skin test, a second positive reaction in 27 (33%) of them strongly suggested re-infection due to ongoing exposure. These results show that a large majority of guinea pigs naturally exposed to human-source strains of multidrug-resistant tuberculosis became infected, but that many resolved their infection and a large majority failed to progress to detectable disease. PMID:21478054

  19. Plague in Guinea Pigs and Its Prevention by Subunit Vaccines

    Science.gov (United States)

    Quenee, Lauriane E.; Ciletti, Nancy; Berube, Bryan; Krausz, Thomas; Elli, Derek; Hermanas, Timothy; Schneewind, Olaf

    2011-01-01

    Human pneumonic plague is a devastating and transmissible disease for which a Food and Drug Administration–approved vaccine is not available. Suitable animal models may be adopted as a surrogate for human plague to fulfill regulatory requirements for vaccine efficacy testing. To develop an alternative to pneumonic plague in nonhuman primates, we explored guinea pigs as a model system. On intranasal instillation of a fully virulent strain, Yersinia pestis CO92, guinea pigs developed lethal lung infections with hemorrhagic necrosis, massive bacterial replication in the respiratory system, and blood-borne dissemination to other organ systems. Expression of the Y. pestis F1 capsule was not required for the development of pulmonary infection; however, the capsule seemed to be important for the establishment of bubonic plague. The mean lethal dose (MLD) for pneumonic plague in guinea pigs was estimated to be 1000 colony-forming units. Immunization of guinea pigs with the recombinant forms of LcrV, a protein that resides at the tip of Yersinia type III secretion needles, or F1 capsule generated robust humoral immune responses. Whereas LcrV immunization resulted in partial protection against pneumonic plague challenge with 250 MLD Y. pestis CO92, immunization with recombinant F1 did not. rV10, a vaccine variant lacking LcrV residues 271-300, elicited protection against pneumonic plague, which seemed to be based on conformational antibodies directed against LcrV. PMID:21406168

  20. Observations of EMIC Triggered Emissions off the Magnetic Equatorial Plane

    Science.gov (United States)

    Grison, B.; Breuillard, H.; Santolik, O.; Cornilleau-Wehrlin, N.

    2016-12-01

    On 19/08/2005 Cluster spacecraft had their perigee close to the dayside of the Earth magnetic equatorial plane, at about 14 hours Magnetic Local Time. The spacecraft crossed the equator from the southern hemisphere toward the northern hemisphere. In the Southern hemisphere, at about -23° magnetic latitude (MLAT) and at distance of 5.25 Earth Radii from Earth, Cluster 3 observes an EMIC triggered emission between the He+ and the proton local gyrofrequencies. The magnetic waveform (STAFF instrument data) is transformed into the Fourier space for a study based on single value decomposition (SVD) analysis. The emission lasts about 30s. The emission frequency rises from 1Hz up to 1.9Hz. The emission polarization is left-hand, its coherence value is high and the propagation angle is field aligned (lower than 30º). The Poynting flux orientation could not be established. Based on previous study results, these properties are indicative of an observation in vicinity of the source region of the triggered emission. From our knowledge this is the first time that EMIC triggered emission are observed off the magnetic equator. In order to identify the source region we study two possibilities: a source region at higher latitudes than the observations (and particles orbiting in "Shabansky" orbits) and a source region close to the magnetic equatorial plane, as reported in previous studies. We propose to identify the source region from ray tracing analysis and to compare the observed propagation angle in several frequency ranges to the ray tracing results.

  1. A tropospheric ozone maximum over the equatorial Southern Indian Ocean

    Directory of Open Access Journals (Sweden)

    L. Zhang

    2012-05-01

    Full Text Available We examine the distribution of tropical tropospheric ozone (O3 from the Microwave Limb Sounder (MLS and the Tropospheric Emission Spectrometer (TES by using a global three-dimensional model of tropospheric chemistry (GEOS-Chem. MLS and TES observations of tropospheric O3 during 2005 to 2009 reveal a distinct, persistent O3 maximum, both in mixing ratio and tropospheric column, in May over the Equatorial Southern Indian Ocean (ESIO. The maximum is most pronounced in 2006 and 2008 and less evident in the other three years. This feature is also consistent with the total column O3 observations from the Ozone Mapping Instrument (OMI and the Atmospheric Infrared Sounder (AIRS. Model results reproduce the observed May O3 maximum and the associated interannual variability. The origin of the maximum reflects a complex interplay of chemical and dynamic factors. The O3 maximum is dominated by the O3 production driven by lightning nitrogen oxides (NOx emissions, which accounts for 62% of the tropospheric column O3 in May 2006. We find the contribution from biomass burning, soil, anthropogenic and biogenic sources to the O3 maximum are rather small. The O3 productions in the lightning outflow from Central Africa and South America both peak in May and are directly responsible for the O3 maximum over the western ESIO. The lightning outflow from Equatorial Asia dominates over the eastern ESIO. The interannual variability of the O3 maximum is driven largely by the anomalous anti-cyclones over the southern Indian Ocean in May 2006 and 2008. The lightning outflow from Central Africa and South America is effectively entrained by the anti-cyclones followed by northward transport to the ESIO.

  2. The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs.

    Science.gov (United States)

    Sun, Yubo; Kiraly, Alex J; Cox, Michael; Mauerhan, David R; Hanley, Edward N

    2018-04-01

    Phosphocitrate (PC) and its analogue, PC-β ethyl ester, inhibit articular cartilage degeneration in Hartley guinea pigs. However, the underlying molecular mechanisms remain unclear. The present study aimed to investigate the hypothesis that PC exerted its disease-modifying effect on osteoarthritis (OA), in part, by inhibiting a molecular program similar to that in the endochondral pathway of ossification. The results demonstrated that severe proteoglycan loss occurred in the superficial and middle zones, as well as in the calcified zone of articular cartilage in the Hartley guinea pigs. Subchondral bone advance was greater in the control Hartley guinea pigs compared with PC- or PC analogue-treated guinea pigs. Resorption of cartilage bars or islands and vascular invasion in the growth plate were also greater in the control guinea pigs compared with the PC- or PC analogue-treated guinea pigs. The levels of matrix metalloproteinase-13 and type X collagen within the articular cartilage and growth plate were significantly increased in the control guinea pigs compared with PC-treated guinea pigs (Pguinea pigs exhibited a hypertrophic phenotype and recapitulated a developmental molecular program similar to the endochondral pathway of ossification. Activation of this molecular program resulted in resorption of calcified articular cartilage and subchondral bone advance. This suggests that PC and PC analogues exerted their OA disease-modifying activity, in part, by inhibiting this molecular program.

  3. Dermatophytes in pet Guinea pigs and rabbits.

    Science.gov (United States)

    Kraemer, A; Mueller, R S; Werckenthin, C; Straubinger, R K; Hein, J

    2012-05-25

    The frequency of dermatophytes in pet Guinea pigs and rabbits. To determine the frequency and types of dermatophytes in pet Guinea pigs and rabbits. First, 2153 samples collected from pet Guinea pigs (n=1132) and rabbits (n=1021) with suspected dermatophytosis and submitted to three different laboratories for fungal culture were analysed. Subsequently, healthy Guinea pigs and rabbits, animals with skin lesions and with noncutaneous diseases were examined prospectively for dermatophytes. Trichophyton (T.) mentagrophytes was the most common fungal species isolated (91.6% and 72.3% of positive cultures from Guinea pigs (n=431) and rabbits (n=83), respectively). Animals with positive fungal culture did not show any gender predisposition, but affected animals were younger than those with negative fungal culture (PGuinea pigs and 0/140 healthy rabbits. In addition, fungal cultures of Guinea pigs with skin lesions (n=26) and other diseases (n=25) were positive in 7.7% and 8.0% respectively. Samples collected from 17 rabbits with skin lesions and 32 rabbits with noncutaneous disease were all negative in culture. T. mentagrophytes is the most common dermatophyte in pet Guinea pigs and rabbits, asymptomatic carriers are regularly seen in Guinea pigs, but not in rabbits. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. The Vaginal Microbiota of Guinea Pigs

    OpenAIRE

    Hafner, L. M.; Rush, C. M.; Timms, P.

    2011-01-01

    The vaginae of four guinea pigs were swabbed and samples cultured aerobically on horse blood agar, in 5 per cent carbon dioxide on MRS agar or anaerobically on anaerobic horse blood agar. Vaginal microbiota consisted almost exclusively of gram-positive bacteria including Corynebacterium, Streptococcus, Enterococcus, Staphylococcus and Lactobacillus species.Keywords: guinea pigs, vaginal microbiota, vaginal vaccines.

  5. African Journals Online: Papua New Guinea

    African Journals Online (AJOL)

    African Journals Online: Papua New Guinea. Home > African Journals Online: Papua New Guinea. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Browse By Category · Browse Alphabetically · Browse By Country · List All Titles · Free to read Titles This Journal is ...

  6. Guinea Pigs: Versatile Animals for the Classroom

    Science.gov (United States)

    Barman, Charles R.

    1977-01-01

    Guinea pigs are presented as versatile classroom animals. Suggestions for animal behavior and genetics studies are given. Also included is information concerning sex determination and the breeding of guinea pigs, and hints on keeping these animals in the classroom. References and illustrations complete the article. (MA)

  7. Endocrine tumours in the guinea pig.

    Science.gov (United States)

    Künzel, Frank; Mayer, Jörg

    2015-12-01

    Functional endocrine tumours have long been thought to be rare in guinea pigs, although conditions such as hyperthyroidism and hyperadrenocorticism have been documented with increasing frequency so the prevalence of hormonal disorders may have been underestimated. Both the clinical signs and diagnosis of hyperthyroidism in guinea pigs appear to be very similar to those described in feline hyperthyroidism, and methimazole has been proven to be a practical therapy option. Hyperadrenocorticism has been confirmed in several guinea pigs with an adrenocorticotropic hormone stimulation test using saliva as a non-invasive sample matrix; trilostane has been successfully used to treat a guinea pig with hyperadrenocorticism. Insulinomas have only rarely been documented in guinea pigs and one animal was effectively treated with diazoxide. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Adenocarcinoma of the gallbladder in guinea pigs

    International Nuclear Information System (INIS)

    Hoch-Ligeti, C.; Congdon, C.C.; Deringer, M.K.; Stewart, H.L.

    1979-01-01

    Adenocarcinoma of the gallbladder developed in 17 of 68 untreated and in 26 of 83 irradiated guinea pigs of inbred strains 2 and 13. The carcinomas spread widely by direct extension and through lymphatic and blood vessels to lymph nodes, mesenteries, omenta, abdominal wall, liver, lungs, bones, and spleen. Whole-body exposure to gamma or x radiation increased both the number of tumors and metastases in male inbred guinea pigs but not in females. Significantly fewer (9 of 98) noninbred than inbred guinea pigs developed gallbladder carcinomas after irradiation. In 9 untreated noninbred guinea pigs gallbladder carcinomas were not found. Inasmuch as the effect of irradiation was not dose-dependent, an indirect systemic effect of irradiation was postulated. This is the first report on the occurrence of spontaneous gallbladder adenocarcinomas in guinea pigs

  9. Continuous day-time time series of E-region equatorial electric fields derived from ground magnetic observatory data

    Science.gov (United States)

    Alken, P.; Chulliat, A.; Maus, S.

    2012-12-01

    The day-time eastward equatorial electric field (EEF) in the ionospheric E-region plays an important role in equatorial ionospheric dynamics. It is responsible for driving the equatorial electrojet (EEJ) current system, equatorial vertical ion drifts, and the equatorial ionization anomaly (EIA). Due to its importance, there is much interest in accurately measuring and modeling the EEF. However, there are limited sources of direct EEF measurements with full temporal and spatial coverage of the equatorial ionosphere. In this work, we propose a method of estimating a continuous day-time time series of the EEF at any longitude, provided there is a pair of ground magnetic observatories in the region which can accurately track changes in the strength of the EEJ. First, we derive a climatological unit latitudinal current profile from direct overflights of the CHAMP satellite and use delta H measurements from the ground observatory pair to determine the magnitude of the current. The time series of current profiles is then inverted for the EEF by solving the governing electrodynamic equations. While this method has previously been applied and validated in the Peruvian sector, in this work we demonstrate the method using a pair of magnetometers in Africa (Samogossoni, SAM, 0.18 degrees magnetic latitude and Tamanrasset, TAM, 11.5 degrees magnetic latitude) and validate the resulting EEF values against the CINDI ion velocity meter (IVM) instrument on the C/NOFS satellite. We find a very good 80% correlation with C/NOFS IVM measurements and a root-mean-square difference of 9 m/s in vertical drift velocity. This technique can be extended to any pair of ground observatories which can capture the day-time strength of the EEJ. We plan to apply this work to more observatory pairs around the globe and distribute real-time equatorial electric field values to the community.

  10. 9 CFR 113.38 - Guinea pig safety test.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Guinea pig safety test. 113.38 Section... Standard Procedures § 113.38 Guinea pig safety test. The guinea pig safety test provided in this section... be injected either intramuscularly or subcutaneously into each of two guinea pigs and the animals...

  11. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig

    DEFF Research Database (Denmark)

    Hansen, Rie Schultz; Olesen, Søren-Peter; Rønn, Lars Christian B

    2008-01-01

    to examining the in vivo effects of NS3623. Injection of 30 mg/kg NS3623 shortened the corrected QT interval by 25 +/- 4% in anaesthetized guinea pigs. Accordingly, 50 mg/kg of NS3623 shortened the QT interval by 30 +/- 6% in conscious guinea pigs. Finally, pharmacologically induced QT prolongation by a h......ERG channel antagonist (0.15 mg/kg E-4031) could be reverted by injection of NS3623 (50 mg/kg) in conscious guinea pigs. In conclusion, the present in vivo study demonstrates that injection of the hERG channel agonist NS3623 results in shortening of the QTc interval as well as reversal of a pharmacologically...... induced QT prolongation in both anaesthetized and conscious guinea pigs....

  12. Guinea pig for meat production: A systematic review of factors affecting the production, carcass and meat quality.

    Science.gov (United States)

    Sánchez-Macías, Davinia; Barba-Maggi, Lida; Morales-delaNuez, Antonio; Palmay-Paredes, Julio

    2018-09-01

    In developing countries, interest in guinea pig farming is growing exponentially because it provides a regular source of high quality animal protein for domestic consumption. Guinea pigs (Cavia porcellus) are prolific animals, grow and are capable of reproduction on a flexible diet, and are adaptable to a wide range of climates. This article mainly reviews findings on guinea pig meat production, including factors affecting raising guinea pigs, carcass and meat quality. We also present some studies that describe biological and pathologic effects on carcass component composition. During the last decades no standard procedure has been established for guinea pig carcass evaluation, which makes very difficult any comparison of results with other studies around the world. Herein we highlight a variety of factors that significantly affect carcass and meat quality. Some of these factors are production systems, environmental and genetic factors, management systems, the diet and health status, age, sex and reproductive management. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. Equatorial wave activity during 2007 over Gadanki, a tropical station

    Indian Academy of Sciences (India)

    been used to investigate the wave activity in the troposphere and lower stratosphere. Waves in the ...... Oltmans S J 2001 Water vapor control at the tropopause by equatorial Kelvin .... observed in UARS microwave limb sounder temperature.

  14. An overview on the equatorial electrojet theoretical grounds

    International Nuclear Information System (INIS)

    Zamlutti, C.J.; Sobral, J.H.A.; Abdu, M.A.

    1988-01-01

    The grounds on which the equatorial electrojet theory is based are reexamined in a way as to suggest specific additional implementations in the existing electrodynamical modeling of this phenomena, making use of now existing improved computer processing speeds. (author) [pt

  15. ITER L 6 equatorial maintenance duct remote handling study

    International Nuclear Information System (INIS)

    Millard, J.

    1996-09-01

    The status and conclusions of a preliminary study of equatorial maintenance duct remote handling is reported. Due to issues with the original duct design a significant portion of the study had to be refocused on equatorial duct layout studies. The study gives an overview of some of the options for design of these ducts and the impact of the design on the equipment to work in the duct. To develop a remote handling concept for creating access through the ducts the following design tasks should be performed: define the operations sequences for equatorial maintenance duct opening and closing; review the remote handling requirements for equatorial maintenance duct opening and closing; design concept for door and pipe handling equipment and to propose preliminary procedures for material handling outsides the duct. 35 figs

  16. Modelling the development of mixing height in near equatorial region

    Energy Technology Data Exchange (ETDEWEB)

    Samah, A.A. [Univ. of Malaya, Air Pollution Research Unit, Kuala Lumpur (Malaysia)

    1997-10-01

    Most current air pollution models were developed for mid-latitude conditions and as such many of the empirical parameters used were based on observations taken in the mid-latitude boundary layer which is physically different from that of the equatorial boundary layer. In the equatorial boundary layer the Coriolis parameter f is small or zero and moisture plays a more important role in the control of stability and the surface energy balance. Therefore air pollution models such as the OMLMULTI or the ADMS which were basically developed for mid-latitude conditions must be applied with some caution and would need some adaptation to properly simulate the properties of equatorial boundary layer. This work elucidates some of the problems of modelling the evolution of mixing height in the equatorial region. The mixing height estimates were compared with routine observations taken during a severe air pollution episodes in Malaysia. (au)

  17. Experimental aerosolized guinea pig-adapted Zaire ebolavirus (variant: Mayinga) causes lethal pneumonia in guinea pigs.

    Science.gov (United States)

    Twenhafel, N A; Shaia, C I; Bunton, T E; Shamblin, J D; Wollen, S E; Pitt, L M; Sizemore, D R; Ogg, M M; Johnston, S C

    2015-01-01

    Eight guinea pigs were aerosolized with guinea pig-adapted Zaire ebolavirus (variant: Mayinga) and developed lethal interstitial pneumonia that was distinct from lesions described in guinea pigs challenged subcutaneously, nonhuman primates challenged by the aerosol route, and natural infection in humans. Guinea pigs succumbed with significant pathologic changes primarily restricted to the lungs. Intracytoplasmic inclusion bodies were observed in many alveolar macrophages. Perivasculitis was noted within the lungs. These changes are unlike those of documented subcutaneously challenged guinea pigs and aerosolized filoviral infections in nonhuman primates and human cases. Similar to findings in subcutaneously challenged guinea pigs, there were only mild lesions in the liver and spleen. To our knowledge, this is the first report of aerosol challenge of guinea pigs with guinea pig-adapted Zaire ebolavirus (variant: Mayinga). Before choosing this model for use in aerosolized ebolavirus studies, scientists and pathologists should be aware that aerosolized guinea pig-adapted Zaire ebolavirus (variant: Mayinga) causes lethal pneumonia in guinea pigs. © The Author(s) 2014.

  18. An equatorial temperature and wind anomaly (ETWA)

    International Nuclear Information System (INIS)

    Raghavarao, R.; Wharton, L.E.; Mayr, H.G.; Brace, L.H.; Spencer, N.W.

    1991-01-01

    Data obtained from the WATS (Wind and Temperature Spectrometer) and LP (Langmuir Probe) experiments on board DE-2 (Dynamic Explorer) during high solar activity show evidence of anomalous latitudinal variations in the zonal winds and temperature at low latitudes. The zonal winds exhibit a broad maximum centered around the dip equator, flanked by minima on either side around 25 degrees; while the temperature exhibits a pronounced bowl-shaped minimum at the dip equator which is flanked by maxima. The two minima in the zonal winds and the corresponding maxima in the temperature are nearly collocated with the crests of the well known Equatorial Ionization Anomaly (EIA). The maximum in the zonal winds and the minimum in the gas temperature are collected with the trough of the EIA. The differences between the maxima and minima in temperature and zonal winds, on many occasions, are observed to exceed 100 K and 100 m/s, respectively. The characteristics of this new phenomenon have eluded present day empirical models of thermospheric temperature and winds. The connection among these variables can be understood from the ion-neutral drag effect on the motions of the neutrals that in turn affect their energy balance

  19. Water-soluble elements in atmospheric particulate matter over tropical and equatorial Atlantic

    International Nuclear Information System (INIS)

    Buat-Menard, Patrick; Morelli, Jacques; Chesselet, Roger

    1974-01-01

    Samples of water-soluble atmospheric particulate matter collected from R/V ''Jean Charcot'' (May to October 1971) and R/V ''James Gilliss'' (October 1972) over Tropical and Equatorial Atlantic were analyzed for Na, Mg, K and Ca by atomic absorption and for Cl and S as SO 4 by colorimetry. Data shows a strong geographical dependence of K and Ca enrichment relative to their elemental ratio to Na in sea-water. Ca enrichment is related to presence of identified soluble calcium minerals in continental dust originating from African deserts (Sahara-Kalahari). This dust does not influence amounts of K in the water-soluble phase. When observed, strong K enrichment appears tightly associated with high concentrations of surface-active organic material in the microlayer derived from high biological activity (Gulf of Guinea). Observed in same samples, SO 4 enrichment could also be controlled by the same source. This SO 4 enrichment balances the observed Cl loss in aerosols accordingly with gaseous HCl formation processes in marine atmosphere [fr

  20. Equatorial night-time spread-F characteristics observed from stations in the Western Pacific

    International Nuclear Information System (INIS)

    Huang Tianxi

    1985-01-01

    A comparative study of the ionospheric spread-F observed at an equatorial station. Port Moresby (9 0 24.5'S, 147 0 9.9'E; magn. Dip lat. 18 0 S), Papua new Guinea, with corresponding data from the East Asian stations during a period 27 May-19 Jun 1983, as well as the same periods for 1981 and 1982, is presented. The Port Moresby spread-F condition is particularly outstanding and persistent at night and the occurrence of spread-F between 23 LT and 05 LT near June solstice is very high, reaching 100% of all observed nights. The latitudinal variation of nocturnal spread-F, its duration and connection with sunspot number are analyzed. The relationship between long-term variation of night-time spread-F occurrence and solar activity during June and December solstices from 1954 up to 1984 at a typical lower magnetic latitudinal station. Wuhan (30 0 32.7'N, 114 0 21.5'E; magn. dip lat. 26 0 N), is also investigated. (author)

  1. Equatorial ionospheric electric fields during the November 2004 magnetic storm

    OpenAIRE

    Fejer, Bela G.; Jensen, J. W.; Kikuchi, T.; Abdu, M. A.; Chau, J. L.

    2007-01-01

    [1] We use radar measurements from the Jicamarca Radio Observatory, magnetometer observations from the Pacific sector and ionosonde data from Brazil to study equatorial ionospheric electric fields during the November 2004 geomagnetic storm. Our data show very large eastward and westward daytime electrojet current perturbations with lifetimes of about an hour (indicative of undershielding and overshielding prompt penetration electric fields) in the Pacific equatorial region during the November...

  2. [Arbovirus circulation in the Republic of Guinea].

    Science.gov (United States)

    Butenko, A M

    1996-01-01

    In 1978-1991 the USSR-Guinea Virological and Microbiological Laboratory functioned in Kindia, the Republic of Guinea. Arbovirus activity in this country was studied by a number of virologists and other specialists. Their personal contribution and achievements in this collaboration are reflected in the present paper. About 74,000 mosquitoes, 100,000 Ixodidae ticks, 1,500 wild birds, 2,700 bats, 106 monkeys, and 308 other mammals, 927 blood samples collected from febrile patients were examined in 1978-1989, using inoculation of new-born white mice. As a result of this work 127 strains of the following arboviruses were isolated: Chikungunia (1 strain), Dengue 2 (4), Saboya (7), Wesselsbron (1), Bunyamwera (4), M'Poko (5), Rift Valley Fever (6), CHF-Congo (9), Dugbe (22), Bhanja (6), Forecariah (2), Jos (26), Abadina (15), Kindia (2), Ark 6956 (1), Fomede (2), Bluetongue (9), Mossuril (2), AnK 6009 (1), and Kolente (2). Dengue 2, Wesselsbron, Bunyamwera, M'Poko, Kindia, Mossuril viruses were isolated from mosquitoes. Ixodidae ticks were sources for isolation of Chikungunia, Saboya, CCHF, Dugbe, Bhanja, Forecaciah, Jos, Abadina, Kindia, Ark 6956, Fomede, Bluetongue, and Kolente viruses. Saboya, RVF, Fomede, Kolente, AnK 6909 were isolated from bats (Chiroptera); Saboya, Abadina, and Bluetongue viruses from birds. One strain of Dugbe virus was originated from the brain of Cercopithecus patas. Bunyamwera and Abadina viruses were isolated from the blood of two febrile patients. Serological identification of many strains was kindly conducted at the Pasteur Institute, Dakar (J. P.Digoutte) and some at the YARU, USA (R. Shope). Kindia and Ark 6956 (Reovirus, gr. Palyam), Fomede (gr. Chobar Gorge), Forecariah (Bunyavirus, gr. Bhanja), Kolente (Rhabdovirus) were identified as an original type of Lagos bat virus. The results of seroepidemiological surveys are also presented.

  3. A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs

    International Nuclear Information System (INIS)

    Zhuang Wenquan; Tan Guosheng; Guo Wenbo; Yang Jianyong

    2012-01-01

    Objective: This study was designed to establish guinea pigs as an animal model for uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM). Methods: Twenty-five female adult guinea pigs were randomly divided into two groups, including a uterine artery casting mould group (n = 10) and a UAE group (n = 15). Pelvic angiography and vascular casting mould were performed in the first group. The anatomical characters of the pelvic cavity in guinea pigs were described. In the second group, the technical feasibility of performing UAE with TAGM in guinea pigs was investigated. The histopathological slides of the uterus of guinea pigs after UAE were examined to inspect the outcomes of UAE. Results: The uterine artery springs from the internal iliac artery, ascends tortuously along the cervix, and gives off vertically 8–10 branches to the cervix uteri and uterine horns. The diameters of the trunk of the uterine artery and its first branch were 0.32 ± 0.027 mm and 0.14 ± 0.01 mm, respectively. For UAE animals, the dosages of 40–120 and 100–300 μm TAGM were 0.033 ± 0.003 ml and 0.015 ± 0.002 ml, respectively. On histopathological slides, embosphere particles were found in the first branches of the uterine artery, the subserous arteries, and the intramural arteries. Inflammatory reactions in the uterus were common in guinea pigs after UAE. Local or dispersed areas of necrosis in uterus also were observed in a few guinea pigs. Conclusions: Guinea pigs are an appropriate and feasible model for UAE with TAGM.

  4. Anti-anaphylactic action of nordihydroguaiaretic acid in antigen sensitized guinea pigs.

    Science.gov (United States)

    Bergren, Dale R; Valentine, Jimmie L

    2016-12-01

    Therapeutic natural products and medicinal herbs has gained popularity. The anti-antigenic action of the plant alkaloid nordihydroguaiaretic acid (NDGA) was studied in ovalbumin (OA)-sensitized guinea pigs. In one series of experiments conscious, non-sedated guinea pigs were challenged with OA aerosol. Specific airway resistance (SR AW ) was monitored using a two-chambered whole-body plethysmograph. OA aerosol increased SR AW above that produced by vehicle administration. Prior NDGA administration by a 1min 0.9% aerosol (w/vol) attenuated the increase in SR AW resulting from OA challenge. In the anesthetized guinea pig pretreated with indomethacin, pyrilamine and propranolol, intravenous OA injection increased intra-tracheal pressure above vehicle injection. Intravenous NDGA administration (5mg/kg) reduced the intra-tracheal pressure increases. In a third series of experiments plasma leukotriene C 4 was measured by radio-immunoassay in 3 groups challenged with OA aerosol: vehicle-treated OA-sensitized, OA-sensitized receiving NDGA and vehicle treated guinea pigs. NDGA pretreatment reduced plasma LTC 4 in response to OA challenge in OA sensitized guinea pigs. This study demonstrates that NDGA is an effective antigenic agent when given by aerosol or intravenous injection in either conscious or anesthetized guinea pigs, respectively. The mechanism of action of NDGA is presumed primarily be due to the blockage of 5-lipoxygenase and therefore the synthesis of leukotrienes. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Increased Severity of Tuberculosis in Guinea Pigs with Type 2 Diabetes

    Science.gov (United States)

    Podell, Brendan K.; Ackart, David F.; Obregon-Henao, Andres; Eck, Sarah P.; Henao-Tamayo, Marcela; Richardson, Michael; Orme, Ian M.; Ordway, Diane J.; Basaraba, Randall J.

    2015-01-01

    Impaired glucose tolerance and type 2 diabetes were induced in guinea pigs to model the emerging comorbidity of Mycobacterium tuberculosis infection in diabetic patients. Type 2 diabetes mellitus was induced by low-dose streptozotocin in guinea pigs rendered glucose intolerant by first feeding a high-fat, high-carbohydrate diet before M. tuberculosis exposure. M. tuberculosis infection of diabetic guinea pigs resulted in severe and rapidly progressive tuberculosis (TB) with a shortened survival interval, more severe pulmonary and extrapulmonary pathology, and a higher bacterial burden compared with glucose-intolerant and nondiabetic controls. Compared with nondiabetics, diabetic guinea pigs with TB had an exacerbated proinflammatory response with more severe granulocytic inflammation and higher gene expression for the cytokines/chemokines interferon-γ, IL-17A, IL-8, and IL-10 in the lung and for interferon-γ, tumor necrosis factor-α, IL-8, and monocyte chemoattractant protein-1 in the spleen. TB disease progression in guinea pigs with impaired glucose tolerance was similar to that of nondiabetic controls in the early stages of infection but was more severe by day 90. The guinea pig model of type 2 diabetes–TB comorbidity mimics important features of the naturally occurring disease in humans. This model will be beneficial in understanding the complex pathogenesis of TB in diabetic patients and to test new strategies to improve TB and diabetes control when the two diseases occur together. PMID:24492198

  6. Serial histopathological changes in irradiated guinea pig lung receiving conventional fractionated and hyperfractionated irradiation

    International Nuclear Information System (INIS)

    Itoh, Satoshi; Inomata, Taisuke; Ogawa, Yasuhiro; Yoshida, Shoji; Sonobe, Hiroshi; Ohtsuki, Yuji

    1999-01-01

    The purpose of this study is to determine serial histopathological differences in guinea pig lungs receiving the same total dose as clinically used between conventional fractionated and hyperfractionated irradiation. The guinea pigs received 80 Gy in 40 daily fractions of 2 Gy each (conventional fractionation), 80 Gy in 80 fractions of 1 Gy each twice a day (hyperfractionation), 81 Gy in 27 daily fractions of 3 Gy each (conventional fractionation), or 81 Gy in 54 fractions of 1.5 Gy each twice a day (hyperfractionation). We evaluated the histopathological changes of irradiated guinea pig lungs at 1, 2, 3, 6, 9, and 12 months after irradiation. The guinea pig lungs that received 81 Gy in 27 daily fractions showed histopathological changes of inflammation including formation of lymph follicles after 6 months. The lungs which received 81 Gy in 54 fractions showed similar but slightly less pronounced changes than those that received 81 Gy in 27 daily fractions. The guinea pig lungs of other groups showed no histopathological changes during the observation period. In hyperfractionated irradiation the damage to the guinea pig lung is quantitatively less than that occurring as a result of conventional fractionated irradiation of the same total dose. (author)

  7. Serial histopathological changes in irradiated guinea pig lung receiving conventional fractionated and hyperfractionated irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Satoshi; Inomata, Taisuke; Ogawa, Yasuhiro; Yoshida, Shoji; Sonobe, Hiroshi; Ohtsuki, Yuji [Kochi Medical School, Nankoku (Japan)

    1999-05-01

    The purpose of this study is to determine serial histopathological differences in guinea pig lungs receiving the same total dose as clinically used between conventional fractionated and hyperfractionated irradiation. The guinea pigs received 80 Gy in 40 daily fractions of 2 Gy each (conventional fractionation), 80 Gy in 80 fractions of 1 Gy each twice a day (hyperfractionation), 81 Gy in 27 daily fractions of 3 Gy each (conventional fractionation), or 81 Gy in 54 fractions of 1.5 Gy each twice a day (hyperfractionation). We evaluated the histopathological changes of irradiated guinea pig lungs at 1, 2, 3, 6, 9, and 12 months after irradiation. The guinea pig lungs that received 81 Gy in 27 daily fractions showed histopathological changes of inflammation including formation of lymph follicles after 6 months. The lungs which received 81 Gy in 54 fractions showed similar but slightly less pronounced changes than those that received 81 Gy in 27 daily fractions. The guinea pig lungs of other groups showed no histopathological changes during the observation period. In hyperfractionated irradiation the damage to the guinea pig lung is quantitatively less than that occurring as a result of conventional fractionated irradiation of the same total dose. (author)

  8. Peat in the mountains of New Guinea

    Directory of Open Access Journals (Sweden)

    G.S. Hope

    2015-11-01

    Full Text Available Peatlands are common in montane areas above 1,000 m in New Guinea and become extensive above 3,000 m in the subalpine zone. In the montane mires, swamp forests and grass or sedge fens predominate on swampy valley bottoms. These mires may be 4–8 m in depth and up to 30,000 years in age. In Papua New Guinea (PNG there is about 2,250 km2 of montane peatland, and Papua Province (the Indonesian western half of the island probably contains much more. Above 3,000 m, peat soils form under blanket bog on slopes as well as on valley floors. Vegetation types include cushion bog, grass bog and sedge fen. Typical peat depths are 0.5‒1 m on slopes, but valley floors and hollows contain up to 10 m of peat. The estimated total extent of mountain peatland is 14,800 km2 with 5,965 km2 in PNG and about 8,800 km2 in Papua Province. The stratigraphy, age structure and vegetation histories of 45 peatland or organic limnic sites above 750 m have been investigated since 1965. These record major vegetation shifts at 28,000, 17,000‒14,000 and 9,000 years ago and a variable history of human disturbance from 14,000 years ago with extensive clearance by the mid-Holocene at some sites. While montane peatlands were important agricultural centres in the Holocene, the introduction of new dryland crops has resulted in the abandonment of some peatlands in the last few centuries. Despite several decades of research, detailed knowledge of the mountain peatlands is poor and this is an obstacle to scientific management.

  9. Authigenic Uranium in Eastern Equatorial Pacific Sediments

    Science.gov (United States)

    Marcantonio, F.; Lyle, M. W.; Loveley, M. R.; Ibrahim, R.

    2014-12-01

    Authigenic U concentrations have been used as an indicator of redox state in marine sediments. Soluble U(VI) in porewaters is reduced to insoluble U(IV) under suboxic conditions setting up a diffusion gradient through which U in bottom waters is supplied to reducing sediments. Researchers have used sedimentary redox enrichment of U as a tool to identify past redox changes, which may be caused by changes in organic carbon rain rates and/or bottom water oxygen levels. Differentiating between these two explanations is important, as the former is tied to the use of authigenic U as a paleoproductivity proxy. We examined sediments from 4 sediment cores retrieved from two different localities in the Panama Basin in the eastern equatorial Pacific. Two cores were retrieved from the northern Panama basin at the Cocos Ridge, (4JC at 5° 44.7'N 85° 45.5' W, 1730 m depth; 8JC at 6° 14.0'N 86° 2.6' W, 1993 m depth), and two were retrieved from the south at the Carnegie Ridge, (11JC at 0° 41.6'S 85° 20.0' W, 2452 m depth; 17JC at 0° 10.8'S 85° 52.0' W, 2846 m depth). Using 230Th systematics and seismic profiling at each of the sites, we've identified significant sediment winnowing (4JC and 11JC) and focusing (8JC and 17JC). At all sites, we believe that changes in age-model-derived sand (i.e., >63µm) mass accumulation rates (MAR) best represent changes in rain rates. Glacial rain rates are higher than those in the Holocene by a factor of 2-3 at both sites. Peak Mn levels (>1%), the brown-to-green color transition (which likely represents the oxic/post-oxic boundary), and peak U concentrations all appear in the same order with increasing depth down core. At the Carnegie sites, where MARs are greater than those at the Cocos sites, increases in authigenic U (up to 4 ppm) occur during the mid- to late Holocene at depths of 10-15 cm. At the Cocos sites, increases in authigenic U (up to 12 ppm) occur lower in the sediment column (25-30 cm) during the late glacial. The decrease

  10. Equatorial spread F studies using SAMI3 with two-dimensional and three-dimensional electrostatics

    Directory of Open Access Journals (Sweden)

    H. C. Aveiro

    2013-12-01

    Full Text Available This letter presents a study of equatorial F region irregularities using the NRL SAMI3/ESF model, comparing results using a two-dimensional (2-D and a three-dimensional (3-D electrostatic potential solution. For the 3-D potential solution, two cases are considered for parallel plasma transport: (1 transport based on the parallel ambipolar field, and (2 transport based on the parallel electric field. The results show that the growth rate of the generalized Rayleigh–Taylor instability is not affected by the choice of the potential solution. However, differences are observed in the structures of the irregularities between the 2-D and 3-D solutions. Additionally, the plasma velocity along the geomagnetic field computed using the full 3-D solution shows complex structures that are not captured by the simplified model. This points out that only the full 3-D model is able to fully capture the complex physics of the equatorial F region.

  11. Transfer of radiobismuth to the fetus in guinea-pigs

    International Nuclear Information System (INIS)

    Richardson, R.B.

    1992-01-01

    A small animal study was carried out in guinea-pigs to measure uptake of radiobismuth ( 207 BiCl 3 ) in fetal organs after intravenous administration to the mother. In this study, little activity was found to cross the placental barrier with 214 Bi across the placenta, is considered to result in a negligible dose from radon short-lived daughters to fetal organs. (author)

  12. Beam-Beam Simulations with GUINEA-PIG

    CERN Document Server

    Schulte, Daniel

    1998-01-01

    While the bunches in a linear collider cross only once, due to their small size they experience a strong beam-beam effect. GUINEA-PIG is a code to simulate the impact of this effect on luminosity and back ground. A short overview of the program is given with examples of its application to the back ground strudies for TESLA, the top quark threshold scan and a possible luminosity monitor, as well as some results for CLIC.

  13. Nonlinear bounce resonances between magnetosonic waves and equatorially mirroring electrons

    Science.gov (United States)

    Chen, Lunjin; Maldonado, Armando; Bortnik, Jacob; Thorne, Richard M.; Li, Jinxing; Dai, Lei; Zhan, Xiaoya

    2015-08-01

    Equatorially mirroring energetic electrons pose an interesting scientific problem, since they generally cannot resonate with any known plasma waves and hence cannot be scattered down to lower pitch angles. Observationally it is well known that the flux of these equatorial particles does not simply continue to build up indefinitely, and so a mechanism must necessarily exist that transports these particles from an equatorial pitch angle of 90° down to lower values. However, this mechanism has not been uniquely identified yet. Here we investigate the mechanism of bounce resonance with equatorial noise (or fast magnetosonic waves). A test particle simulation is used to examine the effects of monochromatic magnetosonic waves on the equatorially mirroring energetic electrons, with a special interest in characterizing the effectiveness of bounce resonances. Our analysis shows that bounce resonances can occur at the first three harmonics of the bounce frequency (nωb, n = 1, 2, and 3) and can effectively reduce the equatorial pitch angle to values where resonant scattering by whistler mode waves becomes possible. We demonstrate that the nature of bounce resonance is nonlinear, and we propose a nonlinear oscillation model for characterizing bounce resonances using two key parameters, effective wave amplitude à and normalized wave number k~z. The threshold for higher harmonic resonance is more strict, favoring higher à and k~z, and the change in equatorial pitch angle is strongly controlled by k~z. We also investigate the dependence of bounce resonance effects on various physical parameters, including wave amplitude, frequency, wave normal angle and initial phase, plasma density, and electron energy. It is found that the effect of bounce resonance is sensitive to the wave normal angle. We suggest that the bounce resonant interaction might lead to an observed pitch angle distribution with a minimum at 90°.

  14. DEMETER Observations of Equatorial Plasma Depletions and Related Ionospheric Phenomena

    Science.gov (United States)

    Berthelier, J.; Malingre, M.; Pfaff, R.; Jasperse, J.; Parrot, M.

    2008-12-01

    DEMETER, the first micro-satellite of the CNES MYRIAD program, was launched from Baikonour on June 29, 2004 on a nearly circular, quasi helio-synchronous polar orbit at ~ 715 km altitude. The DEMETER mission focuses primarily on the search for a possible coupling between seismic activity and ionospheric disturbances as well as on the effects of natural phenomena such as tropospheric thunderstorms and man-made activities on the ionosphere. The scientific payload provides fairly complete measurements of the ionospheric plasma, energetic particles above ~ 70 keV, and plasma waves, up to 20 kHz for the magnetic and 3.3 MHz for the electric components. Several studies related to space weather and ionospheric physics have been conducted over the past years. Following a brief description of the payload and the satellite modes of operation, this presentation will focus on a set of results that provide a new insight into the physics of instabilities in the night-time equatorial ionosphere. The observations were performed during the major magnetic storm of November 2004. Deep plasma depletions were observed on several night-time passes at low latitudes characterized by the decrease of the plasma density by nearly 3 orders of magnitude relative to the undisturbed plasma, and a significant abundance of molecular ions. These features can be best interpreted as resulting from the rise of the F-layer above the satellite altitude over an extended region of the ionosphere. In one of the passes, DEMETER was operated in the Burst mode and the corresponding high resolution data allowed for the discovery of two unexpected phenomena. The first one is the existence of high intensity monochromatic wave packets at the LH frequency that develop during the decay phase of intense bursts of broadband LH turbulence. The broadband LH turbulence is triggered by whistlers emitted by lightning from atmospheric thunderstorms beneath the satellite. The second unexpected feature is the detection of a

  15. The prospection of uranium and thorium ores in desert country and in equatorial forest regions of the Union Francaise

    International Nuclear Information System (INIS)

    Lecoq, J.J.; Bigotte, G.; Hinault, J.; Leconte, J.R.

    1958-01-01

    Since it was founded, the D.R.E.M. has carried out important prospection work in the overseas territories which now make up the Communaute Francaise. This work, now involving almost a million km 2 , represents an experiment scarcely equalled throughout the world. Research in these territories presents both general and technical difficulties, which are especially severe in countries with extreme climates: deserts or dense equatorial forests. The adaptation of various methods of radioactive ore prospection to these regions is described, and also the results obtained. Three particular examples are given in detail: - general exploration in the Hoggar, and reconnoitring of particular indications; - general exploration in the equatorial forest of French Guyana; - detailed study of a sign of uraniferous occurrences and its surroundings in the equatorial zone (Mounana deposit near Franceville (Gabon)). (author) [fr

  16. Asymptotic approach for the nonlinear equatorial long wave interactions

    International Nuclear Information System (INIS)

    Ramirez Gutierrez, Enver; Silva Dias, Pedro L; Raupp, Carlos

    2011-01-01

    In the present work we use an asymptotic approach to obtain the long wave equations. The shallow water equation is put as a function of an external parameter that is a measure of both the spatial scales anisotropy and the fast to slow time ratio. The values given to the external parameters are consistent with those computed using typical values of the perturbations in tropical dynamics. Asymptotically, the model converge toward the long wave model. Thus, it is possible to go toward the long wave approximation through intermediate realizable states. With this approach, the resonant nonlinear wave interactions are studied. To simplify, the reduced dynamics of a single resonant triad is used for some selected equatorial trios. It was verified by both theoretical and numerical results that the nonlinear energy exchange period increases smoothly as we move toward the long wave approach. The magnitude of the energy exchanges is also modified, but in this case depends on the particular triad used and also on the initial energy partition among the triad components. Some implications of the results for the tropical dynamics are discussed. In particular, we discuss the implications of the results for El Nino and the Madden-Julian in connection with other scales of time and spatial variability.

  17. An annotated checklist of the chondrichthyans of Papua New Guinea.

    Science.gov (United States)

    White, William T; Ko'ou, Alfred

    2018-04-19

    An annotated checklist of the chondrichthyan fishes (sharks, rays, and chimaeras) of Papua New Guinean waters is herein presented. The checklist is the result of a large biodiversity study on the chondrichthyan fauna of Papua New Guinea between 2013 and 2017. The chondrichthyan fauna of Papua New Guinea has historically been very poorly known due to a lack of baseline information and limited deepwater exploration. A total of 131 species, comprising 36 families and 68 genera, were recorded. The most speciose families are the Carcharhinidae with 29 species and the Dasyatidae with 23 species. Verified voucher material from various biological collections around the world are provided, with a total of 687 lots recorded comprising 574 whole specimens, 128 sets of jaws and 21 sawfish rostra. This represents the first detailed, verified checklist of chondrichthyans from Papua New Guinean waters.

  18. C-Kit expression in the gallbladder of guinea pig with chronic calculous cholecystitis and the effect of Artemisia capillaris Thunb on interstitial cells of Cajal.

    Science.gov (United States)

    Feng, Hua; Wang, Fang; Wang, Changmiao

    2016-07-01

    To study the c-Kit expression in the gallbladder of cholesterol lithogenic guinea pig model and the effect of Artemisia capillaris Thunb on interstitial cells of Cajal (ICCs). A total of 45 guinea pigs were randomly assigned into three groups: the control group (guinea pigs fed a standard diet, normal group); the model group (guinea pigs fed a cholesterol gallstone-inducing diet); and the Chinese medicine group (guinea pigs fed the cholesterol gallstone-inducing diet and treated with A. capillaris through intragastric administration, therapy group). Each group had 15 guinea pigs. The gallbladders of the guinea pigs were harvested after 8 weeks. C-Kit expression was detected using an immunohistochemistry staining, real-time PCR, and Western blot analyses. The effect of A. capillaris on ICCs was evaluated by muscle strip contraction experiments. C-Kit expression significantly decreased in the gallbladder of model group, but increased in the Chinese medicine group. The Contractility of guinea pig gallbladder muscle strip significantly improved in the Chinese medicine group. Our results indicated that A. capillaris improves gallbladder impairment by up-regulating c-Kit expression, and it also can improve the contractile response of in vitro guinea pig gallbladder muscle strips.

  19. Seasonal influence of ENSO on the Atlantic ITCZ and equatorial South America

    Science.gov (United States)

    Münnich, M.; Neelin, J. D.

    2005-11-01

    In late boreal spring, especially May, a strong relationship exists in observations among precipitation anomalies over equatorial South America and the Atlantic intertropical convergence zone (ITCZ), and eastern equatorial Pacific and central equatorial Atlantic sea surface temperature anomalies (SSTA). A chain of correlations of equatorial Pacific SSTA, western equatorial Atlantic wind stress (WEA), equatorial Atlantic SSTA, sea surface height, and precipitation supports a causal chain in which El Niño/Southern Oscillation (ENSO) induces WEA stress anomalies, which in turn affect Atlantic equatorial ocean dynamics. These correlations show strong seasonality, apparently arising within the atmospheric links of the chain. This pathway and the influence of equatorial Atlantic SSTA on South American rainfall in May appear independent of that of the northern tropical Atlantic. Brazil's Nordeste is affected by the northern tropical Atlantic. The equatorial influence lies further to the north over the eastern Amazon and the Guiana Highlands.

  20. Sensitivity of population smoke exposure to fire locations in Equatorial Asia

    Science.gov (United States)

    Kim, Patrick S.; Jacob, Daniel J.; Mickley, Loretta J.; Koplitz, Shannon N.; Marlier, Miriam E.; DeFries, Ruth S.; Myers, Samuel S.; Chew, Boon Ning; Mao, Yuhao H.

    2015-02-01

    High smoke concentrations in Equatorial Asia, primarily from land conversion to oil palm plantations, affect a densely populated region and represent a serious but poorly quantified air quality concern. Continued expansion of the oil palm industry is expected but the resulting population exposure to smoke is highly dependent on where this expansion takes place. We use the adjoint of the GEOS-Chem chemical transport model to map the sensitivity of smoke concentrations in major Equatorial Asian cities, and for the population-weighted region, to the locations of the fires. We find that fires in southern Sumatra are particularly detrimental, and that a land management policy protecting peatswamp forests in Southeast Sumatra would be of great air quality benefit. Our adjoint sensitivities can be used to immediately infer population exposure to smoke for any future fire emission scenario.

  1. Excitation of electromagnetic proton cyclotron instability by parallel electric field in the equatorial magnetosphere

    International Nuclear Information System (INIS)

    Dixit, S.K.; Azif, Z.A.; Gwal, A.K.

    1994-01-01

    The characteristics of the growth rate of electromagnetic ion cyclotron (EMIC) instability is investigated in a mixture of cold species of ions and warm proton in the presence of weak parallel static electric field. An attempt has been made to explain the excitation of EMIC waves through linear wave-particle (W-P) interaction in the equatorial magnetospheric region. The proton cyclotron instability is modified in presence of weak parallel electric field and the growth rate is computed for equatorial magnetospheric plasma parameters. The results of theoretical investigations of the growth rate are used to explain the excitation mechanism of extremely low frequency/very low frequency (ELF/VLF) waves as observed by satellites. (author). 29 refs., 4 figs

  2. Spatial correlation of the ionsphere total electron content at the equatorial anomaly crest

    International Nuclear Information System (INIS)

    Huang, Y.

    1984-01-01

    The spatial correlation of the ionospheric total electron content (TEC) at the equatorial anomaly crest was studied by recording Faraday rotation angle of the ETS-II geostationary satellite at Lunping and Kaohsiung whose subionospheric points are located at 23.0 0 N, 121.0 0 N, and 20.9 0 N, 121.1 0 E, respectively, and are about 280 km apart. The results show that the spatial correlation of TEC at the equatorial crest region is smaller than that at other places. The day-to-day variabilities of TEC differences between two subionospheric points are quite large. The day-to-day variabilities of the fountain effect seem to play an important role

  3. An Analysis of Unseasonal Equatorial Plasma Bubbles in July 2014

    Science.gov (United States)

    Carter, B. A.; Currie, J. L.; Pradipta, R.; Groves, K. M.; Caton, R. G.; Yokoyama, T.

    2017-12-01

    In the equatorial ionosphere, the Raleigh-Taylor (RT) plasma instability in the post sunset region is known to cause plasma depletions, known as equatorial plasma bubbles (EPBs). These EPBs can have adverse effects on satellite-reliant technologies by causing scintillations in the phase and amplitude of Global Navigation Satellite System (GNSS) signals. The effect of EPBs on satellite-reliant technologies highlights a need for reliable forecasting of EPBs in the low-latitude regions, which requires a solid understanding of their climatology and daily variability. The climatology of EPB occurrence is known to correlate with the angle between the magnetic field and solar terminator. This angle controls the longitudinal E-region conductivity gradient across the day-night terminator, which influences the strength of the pre-reversal enhancement in the upward plasma drift, a dominant term in the linear RT growth rate. This relationship is well established from ground-based GNSS and satellite-based studies. However, reliable forecasts have not been developed by space weather forecasting agencies due to the lack of understanding of EPB daily variability. During July, EPB occurrence is small in the South-East Asia longitude sector due to the relatively large angle between the magnetic field and solar terminator. As a result, the pre-reversal enhancement in the upward plasma drift is typically low during this period, creating less favourable conditions for EPB growth. However, despite the typically low pre-reversal enhancement strength, this analysis reveals that July 2014 is not devoid of EPB events above South-East Asia. These unseasonal EPB events during July 2014 are studied in the context of the prevalently low solar and geomagnetic activity conditions. Given the lack of solar and geomagnetic control, the influence of the lower atmosphere on EPB generation (e.g., via atmospheric gravity wave seeding) is explored. These events provide a unique opportunity to investigate

  4. Snowball Earth termination by destabilization of equatorial permafrost methane clathrate.

    Science.gov (United States)

    Kennedy, Martin; Mrofka, David; von der Borch, Chris

    2008-05-29

    The start of the Ediacaran period is defined by one of the most severe climate change events recorded in Earth history--the recovery from the Marinoan 'snowball' ice age, approximately 635 Myr ago (ref. 1). Marinoan glacial-marine deposits occur at equatorial palaeolatitudes, and are sharply overlain by a thin interval of carbonate that preserves marine carbon and sulphur isotopic excursions of about -5 and +15 parts per thousand, respectively; these deposits are thought to record widespread oceanic carbonate precipitation during postglacial sea level rise. This abrupt transition records a climate system in profound disequilibrium and contrasts sharply with the cyclical stratigraphic signal imparted by the balanced feedbacks modulating Phanerozoic deglaciation. Hypotheses accounting for the abruptness of deglaciation include ice albedo feedback, deep-ocean out-gassing during post-glacial oceanic overturn or methane hydrate destabilization. Here we report the broadest range of oxygen isotope values yet measured in marine sediments (-25 per thousand to +12 per thousand) in methane seeps in Marinoan deglacial sediments underlying the cap carbonate. This range of values is likely to be the result of mixing between ice-sheet-derived meteoric waters and clathrate-derived fluids during the flushing and destabilization of a clathrate field by glacial meltwater. The equatorial palaeolatitude implies a highly volatile shelf permafrost pool that is an order of magnitude larger than that of the present day. A pool of this size could have provided a massive biogeochemical feedback capable of triggering deglaciation and accounting for the global postglacial marine carbon and sulphur isotopic excursions, abrupt unidirectional warming, cap carbonate deposition, and a marine oxygen crisis. Our findings suggest that methane released from low-latitude permafrost clathrates therefore acted as a trigger and/or strong positive feedback for deglaciation and warming. Methane hydrate

  5. Vestibular morphology in the German Waltzing guinea pig.

    Science.gov (United States)

    Kawaguchi, Sachie; Hultcrantz, Malou; Jin, Zhe; Ulfendahl, Mats; Suzuki, Mamoru

    2010-04-01

    The German waltzing guinea pig is a special strain of animal with a recessively inherited inner ear defect, resulting in deafness and a severe vestibular dysfunction. The hearing loss in the cochlea of the German strain is a result of a collapse of the Reissner membrane and the absence of scala media. The vestibular organ has not yet been described. German waltzing guinea pigs (homozygote and heterozygote) of different ages ranging from embryologic age 25 days to adulthood were investigated. The living animals were tested with four different vestibular tests, and the fetuses were controlled according to breeding. The morphology of the vestibular parts (ampulla, saccule, and utricle) was observed by using the light and transmission electron microscopy. Collapse of the membranous labyrinth was found already at embryologic age 50 days and progressed over time. Vestibular dysfunction was noted already from birth. Vestibular atelectasis has been shown to have the same morphology as the reported vestibular dysfunction in the German waltzing guinea pig. Owing to this similarity, this animal can be a good model for vestibular research.

  6. The growth and decay of equatorial backscatter plumes

    Science.gov (United States)

    Tsunoda, R. T.

    1980-02-01

    During the past three years, a series of rocket experiments from the Kwajalein Atoll, Marshall Islands, were conducted to investigate the character of intense, scintillation-producing irregularities that occur in the nighttime equatorial ionosphere. Because the source mechanism of equatorial irregularities, believed to be the Rayleigh-Taylor instability, is analogous to that which generates plasma-density striations in a nuclear-induced environment, there is considerable interest in the underlying physics that controls the characteristics of these irregularities. A primary objective of ALTAIR investigations of equatorial irregularities is to seek an understanding of the underlying physics by establishing the relationship between meter-scale irregularities (detected by ALTAIR), and the large-scale plasma-density depletions (or 'bubbles') that contain the kilometer-scale, scintillation-producing irregularities. We describe the time evolution of backscatter 'plumes' produced by one meter equatorial field-aligned irregularities. Using ALTAIR, a fully steerable backscatter radar, to repeatedly map selected plumes, we characterize the dynamic behavior of plumes in terms of growth and a decay phase. Most of the observed characteristics are found to be consistent with equatorial-irregularity generation predicted by current theories of Rayleigh-Taylor and gradient-drift instabilities. However, other characteristics have been found that suggest key roles played by the eastward neutral wind and by altitude-modulation of the bottomside F layer in establishing the initial conditions for plume growth.

  7. Polysaccharide prodigiosan therapy of irradiated guinea pigs

    International Nuclear Information System (INIS)

    Chertkov, K.S.; Mosina, Z.M.; Khramchenkova, S.P.

    1976-01-01

    In the experiments with irradiated guinea-pigs, a therapeutic action of prodigiosan has been detected. A parenteral administration of the preparation (125 to 500 μg/kg) within the interval from 15 min to 6 hours after a short-term exposure increased the survival of animals to 50%. Prodigiosan administered to guinea-pigs given prolonged irradiation failed to affect the survival rate

  8. Polar and equatorial coronal hole winds at solar minima: From the heliosphere to the inner corona

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, L.; Landi, E., E-mail: lzh@umich.edu [Department of Atmospheric, Oceanic, and Space Sciences, University of Michigan, Ann Arbor, MI 48105 (United States)

    2014-02-01

    Fast solar wind can be accelerated from at least two different sources: polar coronal holes and equatorial coronal holes. Little is known about the relationship between the wind coming from these two different latitudes and whether these two subcategories of fast wind evolve in the same way during the solar cycle. Nineteen years of Ulysses observations, from 1990 to 2009, combined with ACE observations from 1998 to the present provide us with in situ measurements of solar wind properties that span two entire solar cycles. These missions provide an ideal data set to study the properties and evolution of the fast solar wind originating from equatorial and polar holes. In this work, we focus on these two types of fast solar wind during the minima between solar cycles 22 and 23 and 23 and 24. We use data from SWICS, SWOOPS, and VHM/FGM on board Ulysses and SWICS, SWEPAM, and MAG on board ACE to analyze the proton kinetic, thermal, and dynamic characteristics, heavy ion composition, and magnetic field properties of these two fast winds. The comparison shows that: (1) their kinetic, thermal, compositional, and magnetic properties are significantly different at any time during the two minima and (2) they respond differently to the changes in solar activity from cycle 23 to 24. These results indicate that equatorial and polar fast solar wind are two separate subcategories of fast wind. We discuss the implications of these results and relate them to remote-sensing measurements of the properties of polar and equatorial coronal holes carried out in the inner corona during these two solar minima.

  9. Deglacial Western Equatorial Pacific pCO2 Reconstruction Using Boron Isotopes of Planktonic Foraminiferas

    Science.gov (United States)

    Kubota, K.; Yokoyama, Y.; Ishikawa, T.; Sagawa, T.; Ikehara, M.; Yamazaki, T.

    2017-12-01

    During the last deglaciation (ca. 19 - 11 ka), partial pressure of CO2 (pCO2) of the atmosphere increased by 80 μatm. Many paleoceanographers point out that the ocean had played an important role in atmospheric CO2 rise, since the ocean have 60 times larger capacity to store carbon compared to the atmosphere. However, evidence on where carbon was transferred from the ocean to the atmosphere is still lacking, hampering our understanding of global carbon cycles in glacial-interglacial timescales. Boron isotope of skeletons of marine calcifying organisms such as corals and foraminiferas can pin down where CO2 source/sink existed, because boron isotopes of marine calcium carbonates is dependent on seawater pH, from which pCO2 of the past seawater can be reconstructed. In previous studies using the boron isotope teqnique, Martinez-Boti et al. (2015, Nature) and Kubota et al. (2014, Scientific Reports) revealed that central and eastern parts of the equatorial Pacific acted as a CO2 source (i.e., CO2 emission) during the last deglaciation, suggesting the equatorial Pacific's contribution to atmospheric CO2 rise. However, some conflicting results have been confirmed in a marine sediment record from the western part of the equatorial Pacific (Palmer & Pearson, 2003, Science), making the conclusion elusive. In this presentation, we will show new results of Mg/Ca, oxygen isotope, and boron isotope measurements during the last 35 ka on two species of surface dwelling foraminiferas (Globigerinoides ruber and G. sacculifer) which was hand-picked separatedly from a well-dated marine sediment core recovered from the West Caroline Basin (KR05-15 PC01) (Yamazaki et al., 2008, GRL). From the new records, we will discuss how the equatorial Pacific behaved during the last deglaciation and how it related to the global carbon cycles.

  10. ENSO-driven nutrient variability recorded by central equatorial Pacific corals

    Science.gov (United States)

    LaVigne, M.; Nurhati, I. S.; Cobb, K. M.; McGregor, H. V.; Sinclair, D. J.; Sherrell, R. M.

    2012-12-01

    Recent evidence for shifts in global ocean primary productivity suggests that surface ocean nutrient availability is a key link between global climate and ocean carbon cycling. Time-series records from satellite, in situ buoy sensors, and bottle sampling have documented the impact of the El Niño Southern Oscillation (ENSO) on equatorial Pacific hydrography and broad changes in biogeochemistry since the late 1990's, however, data are sparse prior to this. Here we use a new paleoceanographic nutrient proxy, coral P/Ca, to explore the impact of ENSO on nutrient availability in the central equatorial Pacific at higher-resolution than available from in situ nutrient data. Corals from Christmas (157°W 2°N) and Fanning (159°W 4°N) Islands recorded a well-documented decrease in equatorial upwelling as a ~40% decrease in P/Ca during the 1997-98 ENSO cycle, validating the application of this proxy to Pacific Porites corals. We compare the biogeochemical shifts observed through the 1997-98 event with two pre-TOGA-TAO ENSO cycles (1982-83 and 1986-87) reconstructed from a longer Christmas Island core. All three corals revealed ~30-40% P/Ca depletions during ENSO warming as a result of decreased regional wind stress, thermocline depth, and equatorial upwelling velocity. However, at the termination of each El Niño event, surface nutrients did not return to pre-ENSO levels for ~4-12 months after, SST as a result of increased biological draw down of surface nutrients. These records demonstrate the utility of high-resolution coral nutrient archives for understanding the impact of tropical Pacific climate on the nutrient and carbon cycling of this key region.

  11. Polar and equatorial coronal hole winds at solar minima: From the heliosphere to the inner corona

    International Nuclear Information System (INIS)

    Zhao, L.; Landi, E.

    2014-01-01

    Fast solar wind can be accelerated from at least two different sources: polar coronal holes and equatorial coronal holes. Little is known about the relationship between the wind coming from these two different latitudes and whether these two subcategories of fast wind evolve in the same way during the solar cycle. Nineteen years of Ulysses observations, from 1990 to 2009, combined with ACE observations from 1998 to the present provide us with in situ measurements of solar wind properties that span two entire solar cycles. These missions provide an ideal data set to study the properties and evolution of the fast solar wind originating from equatorial and polar holes. In this work, we focus on these two types of fast solar wind during the minima between solar cycles 22 and 23 and 23 and 24. We use data from SWICS, SWOOPS, and VHM/FGM on board Ulysses and SWICS, SWEPAM, and MAG on board ACE to analyze the proton kinetic, thermal, and dynamic characteristics, heavy ion composition, and magnetic field properties of these two fast winds. The comparison shows that: (1) their kinetic, thermal, compositional, and magnetic properties are significantly different at any time during the two minima and (2) they respond differently to the changes in solar activity from cycle 23 to 24. These results indicate that equatorial and polar fast solar wind are two separate subcategories of fast wind. We discuss the implications of these results and relate them to remote-sensing measurements of the properties of polar and equatorial coronal holes carried out in the inner corona during these two solar minima.

  12. Studies of guinea pig immunoglobulin isotype, idiotype and antiidiotype

    International Nuclear Information System (INIS)

    Tirrell, S.M.

    1988-01-01

    Immunization of Guinea pigs with diphtheria toxoid generated antibodies of the IgG class that were capable of neutralizing native toxin in vivo. Sera from these animals were used to affinity purify idiotypic antibodies (AB1). AB1 vaccines derived from the IgG1 class and from F(ab') 2 of IgG1 + IgG2 (IgG1/2) classes were effective in inducing a syngeneic anti-idiotype (AB2) response. Animals immunized with AB1 consisting of both IgG1/2 did not elicit a detectable AB2 response. Binding of homologous 125 I-F(ab') 2 (AB1) to the antiidiotype was inhibited 90% in the presence of DT.F(ab') 2 derived from preimmune serum or had no inhibitory effects on the idiotype-antiidiotype interactions. Two groups of outbred guinea pigs were vaccinated with alum absorbed F(ab') 2 of anti-idiotype IgG1/2 (AB2). Of the ten animals inoculated with AB2, three tested positive by RIA against 125 I-DT. Two of the RIA positive sera contained antibodies that neutralized diphtheria toxin in a rabbit intracutaneous assay. Purification of guinea pig IgG by protein A-Sepharose affinity chromatography resulted in the separation of three distinct IgG populations

  13. Genetic factors of Ebola virus virulence in guinea pigs.

    Science.gov (United States)

    Subbotina, Ekaterina; Dadaeva, Alexandra; Kachko, Alla; Chepurnov, Alexander

    2010-10-01

    Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in primates, whereas in guinea pigs it induces a nonlethal infection with a mild fever and subsequent recovery. We performed 7 selective passages in guinea pigs resulted in obtaining of guinea pig-adapted strain (GPA-P7) strain. By the 7th passage, the infection with EBOV induced a lethal disease in animals accompanied by the characteristic hematological changes: leukocytosis (primarily due to neutrophilia) as well as pronounced deficiencies in platelets, lymphocytes, monocytes and significant decrease of blood neutrophils phagocytic capacity. Increasing of virulence correlated with appearance of several nucleotide substitutions: in the genes NP, A2166G (N566S), VP24, U10784C (L147P), G10557A (M71I), G10805U (R154L), and L, G12286A (V236I). It has been theoretically calculated that the mutations associated with an increase in EBOV virulence can confer characteristic secondary structure on the proteins NP (C-terminal region) and full-sized VP24. (c) 2010 Elsevier B.V. All rights reserved.

  14. The strategy of the key players in the African oil sector (the Gulf of Guinea)?

    International Nuclear Information System (INIS)

    Copinsch, Ph.

    2001-01-01

    The African oil industry, (particularly in the deep water offshore fields of the Gulf of Guinea), is symbolic of the new balance of power taking shape in the oil industry between the international companies and the host state on the one hand, and between the petrol companies themselves on the other. In an area rich in potential and which has become highly competitive, the traditional players in the region's oil development sector (Shell, Chevron and TotalFinaElf) which have for so long been sheltered from genuine competition in their respective areas of activity, must now face up to the renewed ambitions of new 'Super Majors' (in particular ExxonMobil), not to mention those of many independent companies seeking to internationalize their business. Several reasons explain this change. Firstly, the main developments are now taking place offshore with deep water drilling, and financial solidity and technological competence have replaced the closeness of political links as key factors of success. In these conditions, the risk of long term marginalization for the medium-sized companies is considerable. Secondly, the need to achieve profitability stressed by the major petrol groups is opening the door to the independents who are operating a niche policy (based on marginal or mature fields which no longer interest the majors). This type of competition tends to promote activity and to open up new countries to exploration and production (in particular Equatorial Guinea). (author)

  15. English and Tok Pisin (New Guinea Pidgin English) in Papua New Guinea.

    Science.gov (United States)

    Romaine, Suzanne

    1989-01-01

    Tok Pisin, New Guinea Pidgin English, is becoming increasingly important as a "lingua franca" in Papua New Guinea, even though English is the country's official language. Urban versus rural and spoken versus written varieties of the pidgin are examined, and the influence of English on Tok Pisin is investigated. 73 references. (Author/CB)

  16. Equatorial segment of the mid-atlantic ridge

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The Equatorial Segment of the Mid-Atlantic Ridge is a part of this mid-oceanic ridge limited by a cluster of fracture zones - Cape Verde, Marathon, Mercury, Vema, Doldrums, Vernadsky and Sierra Leone - in the North, and a similar cluster of fracture zones - St Paul, Romanche and Chain - in the South. During recent decades, following the publication of the 5. edition of the General Bathymetric Chart of the Oceans (GEBCO), there has been a great deal of geological-geophysical research and mapping of the World Ocean. The results have led to the development of a number of theories concerning the essential heterogeneity of the structure of the ocean floor and, in particular, the heterogeneity of the structure and segmentation of mid-oceanic ridges. Research on the nature of such segmentation is of great importance for an understanding of the processes of development of such ridges and oceanic basins as a whole. Chapter 20 is dedicated to the study of the atlantic ocean mantle by using (Th.U)Th, (Th/U)pb and K/Ti systematics 380 refs.

  17. Equatorial segment of the mid-atlantic ridge

    International Nuclear Information System (INIS)

    1996-01-01

    The Equatorial Segment of the Mid-Atlantic Ridge is a part of this mid-oceanic ridge limited by a cluster of fracture zones - Cape Verde, Marathon, Mercury, Vema, Doldrums, Vernadsky and Sierra Leone - in the North, and a similar cluster of fracture zones - St Paul, Romanche and Chain - in the South. During recent decades, following the publication of the 5. edition of the General Bathymetric Chart of the Oceans (GEBCO), there has been a great deal of geological-geophysical research and mapping of the World Ocean. The results have led to the development of a number of theories concerning the essential heterogeneity of the structure of the ocean floor and, in particular, the heterogeneity of the structure and segmentation of mid-oceanic ridges. Research on the nature of such segmentation is of great importance for an understanding of the processes of development of such ridges and oceanic basins as a whole. Chapter 20 is dedicated to the study of the atlantic ocean mantle by using (Th.U)Th, (Th/U)pb and K/Ti systematics

  18. A mantle plume model for the Equatorial Highlands of Venus

    Science.gov (United States)

    Kiefer, Walter S.; Hager, Bradford H.

    1991-01-01

    The possibility that the Equatorial Highlands are the surface expressions of hot upwelling mantle plumes is considered via a series of mantle plume models developed using a cylindrical axisymmetric finite element code and depth-dependent Newtonian rheology. The results are scaled by assuming whole mantle convection and that Venus and the earth have similar mantle heat flows. The best model fits are for Beta and Atla. The common feature of the allowed viscosity models is that they lack a pronounced low-viscosity zone in the upper mantle. The shape of Venus's long-wavelength admittance spectrum and the slope of its geoid spectrum are also consistent with the lack of a low-viscosity zone. It is argued that the lack of an asthenosphere on Venus is due to the mantle of Venus being drier than the earth's mantle. Mantle plumes may also have contributed to the formation of some smaller highland swells, such as the Bell and Eistla regions and the Hathor/Innini/Ushas region.

  19. Improved design of an ITER equatorial EC launcher

    International Nuclear Information System (INIS)

    Takahashi, K.; Kajiwara, K.; Kobayashi, N.; Kasugai, A.; Sakamoto, K.

    2008-01-01

    New design improvements for an ITER equatorial EC launcher are described. A design of the front shield modules was evaluated analytically. The results indicate that these modules can withstand the electromagnetic forces induced by plasma disruption and vertical plasma motion. The steering mirror mock-up including the spiral cooling tubes was fabricated based on the present design with application of the hot isostatic pressing technique to bond the copper alloy mirror body and the embedded stainless steel cooling tubes. The test of water flow was carried out and the expected flow rate was successfully obtained. A quasi-optical (QO) transmission layout has been proposed instead of the waveguide lines. The advantage of this option is possibly to increase the reliability in terms of fabrication and refurbishment. According to the beam propagation analysis, it is verified that transmission loss at the QO region is 1.1%-2.2%, which is comparable to the reference design. The peak heat load on the steering mirror surface could be reduced by 55%, which relaxes the mirror design

  20. Equatorial segment of the mid-atlantic ridge

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The Equatorial Segment of the Mid-Atlantic Ridge is a part of this mid-oceanic ridge limited by a cluster of fracture zones - Cape Verde, Marathon, Mercury, Vema, Doldrums, Vernadsky and Sierra Leone - in the North, and a similar cluster of fracture zones - St Paul, Romanche and Chain - in the South. During recent decades, following the publication of the 5. edition of the General Bathymetric Chart of the Oceans (GEBCO), there has been a great deal of geological-geophysical research and mapping of the World Ocean. The results have led to the development of a number of theories concerning the essential heterogeneity of the structure of the ocean floor and, in particular, the heterogeneity of the structure and segmentation of mid-oceanic ridges. Research on the nature of such segmentation is of great importance for an understanding of the processes of development of such ridges and oceanic basins as a whole. Chapter 20 is dedicated to the study of the atlantic ocean mantle by using (Th.U)Th, (Th/U)pb and K/Ti systematics 380 refs.

  1. GENETIC CONTROL IN GUINEA PIGS OF IMMUNE RESPONSE TO CONJUGATES OF HAPTENS AND POLY-L-LYSINE.

    Science.gov (United States)

    LEVINE, B B; BENACERRAF, B

    1965-01-29

    Random-bred Hartley strain guinea pigs which do not respond immunologically to conjugates of hapten and poly-L-lysine mere mated with heterozygous guinea pigs which do. These responders were considered heterozygous for this trait since their mating resulted in at least one nonresponder offspring. Of 31 offspring from 10 breeding pairs (nonresponder x heterozygous responder) 14 were responders. There was no evidence that this trait is sex-linked. This finding confirms the view that, in guinea pigs, development of an immune response to the aforementioned conjugates is a genetically transmitted autosomal, unigenic Mendelian dominant trait.

  2. Expression Profile of the Integrin Receptor Subunits in the Guinea Pig Sclera.

    Science.gov (United States)

    Wang, Kevin K; Metlapally, Ravikanth; Wildsoet, Christine F

    2017-06-01

    The ocular dimensional changes in myopia reflect increased scleral remodeling, and in high myopia, loss of scleral integrity leads to biomechanical weakening and continued scleral creep. As integrins, a type of cell surface receptors, have been linked to scleral remodeling, they represent potential targets for myopia therapies. As a first step, this study aimed to characterize the integrin subunits at the messenger RNA level in the sclera of the guinea pig, a more recently added but increasingly used animal model for myopia research. Primers for α and β integrin subunits were designed using NCBI/UCSC Genome Browser and Primer3 software tools. Total RNA was extracted from normal scleral tissue and isolated cultured scleral fibroblasts, as well as liver and lung, as reference tissues, all from guinea pig. cDNA was produced by reverse transcription, PCR was used to amplify products of predetermined sizes, and products were sequenced using standard methods. Guinea pig scleral tissue expressed all known integrin alpha subunits except αD and αE. The latter integrin subunits were also not expressed by cultured guinea pig scleral fibroblasts; however, their expression was confirmed in guinea pig liver. In addition, isolated cultured fibroblasts did not express integrin subunits αL, αM, and αX. This difference between results for cultured cells and intact sclera presumably reflects the presence in the latter of additional cell types. Both guinea pig scleral tissue and isolated scleral fibroblasts expressed all known integrin beta subunits. All results were verified through sequencing. The possible contributions of integrins to scleral remodeling make them plausible targets for myopia prevention. Data from this study will help guide future ex vivo and in vitro studies directed at understanding the relationship between scleral integrins and ocular growth regulation in the guinea pig model for myopia.

  3. Large-scale shifts in phytoplankton groups in the Equatorial Pacific during ENSO cycles

    Directory of Open Access Journals (Sweden)

    I. Masotti

    2011-03-01

    Full Text Available The El Niño Southern Oscillation (ENSO drives important changes in the marine productivity of the Equatorial Pacific, in particular during major El Niño/La Niña transitions. Changes in environmental conditions associated with these climatic events also likely impact phytoplankton composition. In this work, the distribution of four major phytoplankton groups (nanoeucaryotes, Prochlorococcus, Synechococcus, and diatoms was examined between 1996 and 2007 by applying the PHYSAT algorithm to the ocean color data archive from the Ocean Color and Temperature Sensor (OCTS and Sea-viewing Wide Field-of-view Sensor (SeaWiFS. Coincident with the decrease in chlorophyll concentrations, a large-scale shift in the phytoplankton composition of the Equatorial Pacific, that was characterized by a decrease in Synechococcus and an increase in nanoeucaryote dominance, was observed during the early stages of both the strong El Niño of 1997 and the moderate El Niño of 2006. A significant increase in diatoms dominance was observed in the Equatorial Pacific during the 1998 La Niña and was associated with elevated marine productivity. An analysis of the environmental variables using a coupled physical-biogeochemical model (NEMO-PISCES suggests that the Synechococcus dominance decrease during the two El Niño events was associated with an abrupt decline in nutrient availability (−0.9 to −2.5 μM NO3 month−1. Alternatively, increased nutrient availability (3 μM NO3 month−1 during the 1998 La Niña resulted in Equatorial Pacific dominance diatom increase. Despite these phytoplankton community shifts, the mean composition is restored after a few months, which suggests resilience in community structure.

  4. Range expansion drives dispersal evolution in an equatorial three-species symbiosis.

    Directory of Open Access Journals (Sweden)

    Guillaume Léotard

    Full Text Available Recurrent climatic oscillations have produced dramatic changes in species distributions. This process has been proposed to be a major evolutionary force, shaping many life history traits of species, and to govern global patterns of biodiversity at different scales. During range expansions selection may favor the evolution of higher dispersal, and symbiotic interactions may be affected. It has been argued that a weakness of climate fluctuation-driven range dynamics at equatorial latitudes has facilitated the persistence there of more specialized species and interactions. However, how much the biology and ecology of species is changed by range dynamics has seldom been investigated, particularly in equatorial regions.We studied a three-species symbiosis endemic to coastal equatorial rainforests in Cameroon, where the impact of range dynamics is supposed to be limited, comprised of two species-specific obligate mutualists--an ant-plant and its protective ant--and a species-specific ant parasite of this mutualism. We combined analyses of within-species genetic diversity and of phenotypic variation in a transect at the southern range limit of this ant-plant system. All three species present congruent genetic signatures of recent gradual southward expansion, a result compatible with available regional paleoclimatic data. As predicted, this expansion has been accompanied by the evolution of more dispersive traits in the two ant species. In contrast, we detected no evidence of change in lifetime reproductive strategy in the tree, nor in its investment in food resources provided to its symbiotic ants.Despite the decreasing investment in protective workers and the increasing investment in dispersing females by both the mutualistic and the parasitic ant species, there was no evidence of destabilization of the symbiosis at the colonization front. To our knowledge, we provide here the first evidence at equatorial latitudes that biological traits associated

  5. Range expansion drives dispersal evolution in an equatorial three-species symbiosis.

    Science.gov (United States)

    Léotard, Guillaume; Debout, Gabriel; Dalecky, Ambroise; Guillot, Sylvain; Gaume, Laurence; McKey, Doyle; Kjellberg, Finn

    2009-01-01

    Recurrent climatic oscillations have produced dramatic changes in species distributions. This process has been proposed to be a major evolutionary force, shaping many life history traits of species, and to govern global patterns of biodiversity at different scales. During range expansions selection may favor the evolution of higher dispersal, and symbiotic interactions may be affected. It has been argued that a weakness of climate fluctuation-driven range dynamics at equatorial latitudes has facilitated the persistence there of more specialized species and interactions. However, how much the biology and ecology of species is changed by range dynamics has seldom been investigated, particularly in equatorial regions. We studied a three-species symbiosis endemic to coastal equatorial rainforests in Cameroon, where the impact of range dynamics is supposed to be limited, comprised of two species-specific obligate mutualists--an ant-plant and its protective ant--and a species-specific ant parasite of this mutualism. We combined analyses of within-species genetic diversity and of phenotypic variation in a transect at the southern range limit of this ant-plant system. All three species present congruent genetic signatures of recent gradual southward expansion, a result compatible with available regional paleoclimatic data. As predicted, this expansion has been accompanied by the evolution of more dispersive traits in the two ant species. In contrast, we detected no evidence of change in lifetime reproductive strategy in the tree, nor in its investment in food resources provided to its symbiotic ants. Despite the decreasing investment in protective workers and the increasing investment in dispersing females by both the mutualistic and the parasitic ant species, there was no evidence of destabilization of the symbiosis at the colonization front. To our knowledge, we provide here the first evidence at equatorial latitudes that biological traits associated with dispersal are

  6. Seasonal cycle of cross-equatorial flow in the central Indian Ocean

    Science.gov (United States)

    Wang, Yi; McPhaden, Michael J.

    2017-05-01

    This study investigates the seasonal cycle of meridional currents in the upper layers of central equatorial Indian Ocean using acoustic Doppler current profiler (ADCP) and other data over the period 2004-2013. The ADCP data set collected along 80.5°E is the most comprehensive collection of direct velocity measurements in the central Indian Ocean to date, providing new insights into the meridional circulation in this region. We find that mean volume transport is southward across the equator in the central Indian Ocean in approximate Sverdrup balance with the wind stress curl. In addition, mean westerly wind stress near the equator drives convergent Ekman flow in the surface layer and subsurface divergent geostrophic flow in the thermocline at 50-150 m depths. In response to a mean northward component of the surface wind stress, the maximum surface layer convergence is shifted off the equator to between 0.5° and 1°N. Evidence is also presented for the existence of a shallow equatorial roll consisting of a northward wind-driven surface drift overlaying the southward directed subsurface Sverdrup transport. Seasonal variations are characterized by cross-equatorial transports flowing from the summer to the winter hemisphere in quasi-steady Sverdrup balance with the wind stress curl. In addition, semiannually varying westerly monsoon transition winds lead to semiannual enhancements of surface layer Ekman convergence and geostrophic divergence in the thermocline. These results quantify expectations from ocean circulation theories for equatorial Indian Ocean meridional circulation patterns with a high degree of confidence given the length of the data records.

  7. Deciphering Equatorial Pacific Deep Sea Sediment Transport Regimes by Core-Log-Seismic Integration

    Science.gov (United States)

    Ortiz, E.; Tominaga, M.; Marcantonio, F.

    2017-12-01

    Investigating deep-sea sediment transportation and deposition regimes is a key to accurately understand implications from geological information recorded by pelagic sediments, e.g. climate signals. However, except for physical oceanographic particle trap experiments, geochemical analyses of in situsediments, and theoretical modeling of the relation between the bottom currents and sediment particle flux, it has remained a challenging task to document the movement of deep sea sediments, that takes place over time. We utilized high-resolution, multichannel reflection seismic data from the eastern equatorial Pacific region with drilling and logging results from two Integrated Ocean Drilling Program (IODP) sites, the Pacific Equatorial Age Transect (PEAT) 7 (Site U1337) and 8 (Site U1338), to characterize sediment transportation regimes on 18-24 Ma oceanic crust. Site U1337, constructed by a series of distinct abyssal hills and abyssal basins; Site U1338, located 570 km SE from Site U1337 site and constructed by a series of ridges, seamounts, and abyssal hills. These sites are of particular interest due to their proximity to the equatorial productivity zone, areas with high sedimentation rates and preservation of carbonate-bearing sediment that provide invaluable insights on equatorial Pacific ecosystems and carbon cycle. We integrate downhole geophysical logging data as well as geochemistry and physical properties measurements on recovered cores from IODP Sites U1337 and U1338 to comprehensively examine the mobility of deep-sea sediments and sediment diagenesis over times in a quasi-3D manner. We also examine 1100 km of high resolution underway seismic surveys from site survey lines in between PEAT 7 and 8 in order to investigate changes in sediment transportation between both sites. Integrating detailed seismic interpretations, high resolution core data, and 230Th flux measurements we aim to create a detailed chronological sedimentation and sediment diagenesis history

  8. Repeated Storage of Respired Carbon in the Equatorial Pacific Ocean Over the Last Three Glacial Cycles

    Science.gov (United States)

    Jacobel, A. W.; McManus, J. F.; Anderson, R. F.; Winckler, G.

    2017-12-01

    As the largest reservoir of carbon actively exchanging with the atmosphere on glacial-interglacial timescales, the deep ocean has been implicated as the likely location of carbon dioxide sequestration during Pleistocene glaciations. Despite strong theoretical underpinnings for this expectation, it has been challenging to identify unequivocal evidence for respired carbon storage in the paleoceanographic record. Data on the rate of ocean ventilation derived from paired planktonic-benthic foraminifera radiocarbon ages conflict across the equatorial Pacific, and different proxy reconstructions contradict one another about the depth and origin of the watermass containing the respired carbon. Because any change in the storage of respiratory carbon must be accompanied by corresponding changes in dissolved oxygen concentrations, proxy data reflecting bottom water oxygenation are of value in addressing these apparent inconsistencies. We present new records of the redox sensitive metal uranium from the central equatorial Pacific to qualitatively identify intervals associated with respiratory carbon storage over the past 350 kyr. Our data reveal periods of deep ocean authigenic uranium deposition in association with each of the last three glacial maxima. Equatorial Pacific export productivity data show intervals with abundant authigenic uranium are not associated with local productivity increases, indicating episodic precipitation of authigenic uranium does not directly reflect increases in situ microbial respiration, but rather occurs in response to basin-wide decreases in deep water oxygen concentrations. We combine our new data with previously published results to propose a picture of glacial carbon storage and equatorial Pacific watermass structure that is internally consistent. We conclude that respired carbon storage in the Pacific was a persistent feature of Pleistocene glaciations.

  9. Equatorial Scintillation Study at Ilorin and Nsukka, Nigeria during Year 2011-2012

    Science.gov (United States)

    Akala, A.

    2017-12-01

    This study presents GNSS scintillations over Ilorin (8.48 oN, 4.54 oE, and mag lat: 1.83oS) and Nsukka (6.84 oN, 7.37 oE, and mag lat: 2.94oS), Nigeria during year 2011-2012. The two stations are located within the inner flank of the equatorial ionization anomaly. Firstly, we investigated the climatology of equatorial scintillations at the two stations. We suppressed multipath effects on the data by imposing a 300 elevation masking on the data. In addition, we investigated scintillation occurrences at the two locations on a satellite-by-satellite basis at varying elevation angles. The source of scintillation records at low-elevation angle is attributed to multipath, while that at high-elevation angle is attributed to ionospheric irregularities. Seasonally, scintillations recorded highest occurrences during March equinox, and the least during June solstice. The trend of scintillations, at both low- and high-elevation angles at the two stations were almost the same. EGNOS satellites signals scintillated at the two locations during the time intervals when GPS satellites signals experienced scintillations. These results could support the development of scintillation models for equatorial Africa, and could also be of benefit to GPS and EGNOS service providers and designers, with a view to providing robust services for GNSS user community in Africa.

  10. Population exposure to hazardous air quality due to the 2015 fires in Equatorial Asia.

    Science.gov (United States)

    Crippa, P; Castruccio, S; Archer-Nicholls, S; Lebron, G B; Kuwata, M; Thota, A; Sumin, S; Butt, E; Wiedinmyer, C; Spracklen, D V

    2016-11-16

    Vegetation and peatland fires cause poor air quality and thousands of premature deaths across densely populated regions in Equatorial Asia. Strong El-Niño and positive Indian Ocean Dipole conditions are associated with an increase in the frequency and intensity of wildfires in Indonesia and Borneo, enhancing population exposure to hazardous concentrations of smoke and air pollutants. Here we investigate the impact on air quality and population exposure of wildfires in Equatorial Asia during Fall 2015, which were the largest over the past two decades. We performed high-resolution simulations using the Weather Research and Forecasting model with Chemistry based on a new fire emission product. The model captures the spatio-temporal variability of extreme pollution episodes relative to space- and ground-based observations and allows for identification of pollution sources and transport over Equatorial Asia. We calculate that high particulate matter concentrations from fires during Fall 2015 were responsible for persistent exposure of 69 million people to unhealthy air quality conditions. Short-term exposure to this pollution may have caused 11,880 (6,153-17,270) excess mortalities. Results from this research provide decision-relevant information to policy makers regarding the impact of land use changes and human driven deforestation on fire frequency and population exposure to degraded air quality.

  11. Assessing and Optimizing Argo profile mapping : An example in the Equatorial Pacific

    Science.gov (United States)

    Gasparin, Florent; Roemmich, Dean; Gilson, John; Sprintall, Janet

    2014-05-01

    Estimation of subsurface temperature, salinity and velocity has been revolutionized over the last decade as a result of development and deployment of the Argo Program. Argo products have become one of the major observational tools in Oceanography, used in a wide range of basic research, operational models, and education applications. To assess the skill of Argo in estimating oceanic conditions at different scales of variability in the Equatorial Pacific, we optimize Argo profile mapping by focusing on the covariance function. Decorrelation scales are discussed as well as impacts of several different interpolation schemes. The optimization is based on three points 1) Functional representation of the Argo sampled covariance, 2) Realism/Accuracy of the mapping errors and 3) Comparison with independent data such as TAO moorings and sea surface height. The last points show that Argo can represent more than 90% of the total TAO variance and around 80% of the intraseasonal TAO variability (between 10 and 100 days) at the Equator. As an illustration of the improvement, we show how Argo profiles can reveal the vertical structure and vertical phase propagation corresponding to the steric height annual cycle. We also discuss how this unique equatorial wave phenomena is modified during El Nino/La Nina events. This work anticipates a field experiment beginning in early 2014 and can be used for assessing and adapting the equatorial observational network.

  12. Observations in equatorial anomaly region of total electron content enhancements and depletions

    Directory of Open Access Journals (Sweden)

    N. Dashora

    2005-10-01

    Full Text Available A GSV 4004A GPS receiver has been operational near the crest of the equatorial anomaly at Udaipur, India for some time now. The receiver provides the line-of-sight total electron content (TEC, the phase and amplitude scintillation index, σφ and S4, respectively. This paper presents the first results on the nighttime TEC depletions associated with the equatorial spread F in the Indian zone. The TEC depletions are found to be very well correlated with the increased S4 index. A new feature of low-latitude TEC is also reported, concerning the observation of isolated and localized TEC enhancements in the nighttime low-latitude ionosphere. The TEC enhancements are not correlated with the S4 index. The TEC enhancements have also been observed along with the TEC depletions. The TEC enhancements have been interpreted as the manifestation of the plasma density enhancements reported by Le et al. (2003.

    Keywords. Ionosphere (Equatorial ionosphere; Ionospheric irregularities

  13. The magnetic field of the equatorial magnetotail from 10 to 40 earth radii

    Science.gov (United States)

    Fairfield, D. H.

    1986-01-01

    A statistical study of IMP 6, 7, and 8 magnetotail magnetic field measurements near the equatorial plane reveals new information about various aspects of magnetospheric structure. More magnetic flux crosses the equatorial plane on the dawn and dusk flanks of the tail than near midnight, but no evidence is found for a dependence on the interplanetary magnetic field sector polarity. Field magnitudes within 3 earth radii of the equatorial plane near dawn are more than twice as large as those near dusk for Xsm = -20 to -10 earth radii. The frequency of occurrence of southward fields is greatest near midnight, and such fields are seen almost twice as often for Xsm = -20 to -10 earth radii as for Xsm beyond -20 earth radii. This latter result supports the idea that the midnight region of the tail between 10 and 20 is a special location where neutral lines are particularly apt to form. Such a neutral line will approach nearest the earth in the midnight and premidnight region, where substorms are thought to have their onset.

  14. Population exposure to hazardous air quality due to the 2015 fires in Equatorial Asia

    Science.gov (United States)

    Crippa, P.; Castruccio, S.; Archer-Nicholls, S.; Lebron, G. B.; Kuwata, M.; Thota, A.; Sumin, S.; Butt, E.; Wiedinmyer, C.; Spracklen, D. V.

    2016-11-01

    Vegetation and peatland fires cause poor air quality and thousands of premature deaths across densely populated regions in Equatorial Asia. Strong El-Niño and positive Indian Ocean Dipole conditions are associated with an increase in the frequency and intensity of wildfires in Indonesia and Borneo, enhancing population exposure to hazardous concentrations of smoke and air pollutants. Here we investigate the impact on air quality and population exposure of wildfires in Equatorial Asia during Fall 2015, which were the largest over the past two decades. We performed high-resolution simulations using the Weather Research and Forecasting model with Chemistry based on a new fire emission product. The model captures the spatio-temporal variability of extreme pollution episodes relative to space- and ground-based observations and allows for identification of pollution sources and transport over Equatorial Asia. We calculate that high particulate matter concentrations from fires during Fall 2015 were responsible for persistent exposure of 69 million people to unhealthy air quality conditions. Short-term exposure to this pollution may have caused 11,880 (6,153-17,270) excess mortalities. Results from this research provide decision-relevant information to policy makers regarding the impact of land use changes and human driven deforestation on fire frequency and population exposure to degraded air quality.

  15. Longitudinal Variation and Waves in Jupiter's South Equatorial Wind Jet

    Science.gov (United States)

    Simon-Miller, A. A.; Rogers, John H.; Gierasch, Peter J.; Choi, David; Allison, Michael; Adamoli, Gianluigi; Mettig, Hans-Joerg

    2012-01-01

    We have conducted a detailed study of the cloud features in the strong southern equatorial wind jet near 7.5 S planetographic latitude. To understand the apparent variations in average zonal wind jet velocity at this latitude [e.g.. 1,2,3], we have searched for variations iIi both feature latitude and velocity with longitude and time. In particular, we focused on the repetitive chevron-shaped dark spots visible on most dates and the more transient large anticyclonic system known as the South Equatorial Disturbance (SED). These small dark spots are interpreted as cloud holes, and are often used as material tracers of the wind field.

  16. Instability of equatorial protons in Jupiter's mid-magnetosphere

    International Nuclear Information System (INIS)

    Northrop, T.G.; Schardt, A.W.

    1980-01-01

    Two different models for the distribution function are fit to the Jovian protons seen by Pioneer 10 inbound. The models reproduce the observed energy and angular distributions. These models are then used to assess the collisionless mirror instability. Because of the pancake proton angular distributions in the equatorial ring current region, the ring current particle population appears to be mirror unstable at times, with instability growth rates of approx.10 min. Such a time is consistent with observed proton flux autocorrelation times. An instability such as this (there are other candidates) may be responsible for the previously established proton flux flowing parallel to the magnetic field away from the equatorial region

  17. Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs.

    Science.gov (United States)

    Cheng, Yan-Mei; Cao, Ai-Li; Zheng, Jian-Pu; Wang, Hong-Wei; Sun, Yong-Shun; Liu, Chun-Fang; Zhang, Bei-Bei; Wang, Yi; Zhu, Sheng-Liang; Wu, Da-Zheng

    2014-11-01

    Gastroesophageal reflux is a common disorder closely related to chronic airway diseases, such as chronic cough, asthma, chronic bronchitis, and chronic obstructive disease. Indeed, gastroesophageal acid reflux into the respiratory tract causes bronchoconstriction, but the underlying mechanisms have still not been clarified. This study aimed to elucidate functional changes of bronchial smooth muscles (BSMs) isolated from guinea pigs in an animal model of gastroesophageal reflux. The marked airway inflammation, hyperresponsiveness and remodeling were observed after guinea pigs were exposed to intraesophageal HCl infusion for 14 days. In addition, contractile responses to acetylcholine (ACh), KCl, electrical field stimulation, and extracellular Ca(2+) were greater in guinea pigs infused with HCl compared with control groups. The L-type voltage-dependent Ca(2+) channels (L-VDCC) blocker, nicardipine, significantly inhibited ACh- and Ca(2+)-enhanced BSM contractions in guinea pigs infused with HCl. The Rho-kinase inhibitor, Y27632, attenuated ACh-enhanced BSM contractions in guinea pigs infused with HCl. Moreover, mRNA and protein expressions for muscarinic M2 and M3 receptors, RhoA, and L-VDCC in BSM were detected by real-time PCR and Western blot. Expressions of mRNA and protein for muscarinic M3 receptors, RhoA, and L-VDCC were greater than in BSM of HCl-infused guinea pigs, whereas levels of muscarinic M2 receptors were unchanged. We demonstrate that acid infusion to the lower esophagus and, subsequently, microaspiration into the respiratory tract in guinea pigs leads to airway hyperresponsiveness and overactive BSM. Functional and molecular results indicate that overactive BSM is the reason for enhancement of extracellular Ca(2+) influx via L-VDCC and Ca(2+) sensitization through Rho-kinase signaling.

  18. An Assessment of Language Needs for Technical Communication in a Multilingual Speech Community: Implications for Teaching LSP in Papua New Guinea.

    Science.gov (United States)

    Moody, James

    A survey of 98 Papua New Guinea technical university graduates in the applied sciences, engineering fields, and forestry investigated their language skill use and language needs in the workplace. Results indicate that, as in Papua New Guinea society in general, English and Tok Pisin are the two most important languages for technical communication…

  19. Redox Conditions and Related Color Change in Eastern Equatorial Pacific Sediments: IODP Site U1334

    Science.gov (United States)

    Kordesch, W. E.; Gussone, N. C.; Hathorne, E. C.; Kimoto, K.; Delaney, M. L.

    2011-12-01

    This study was prompted by a 65 m thick brown-green color change in deep-sea sediments of IODP Site U1334 (0-38 Ma, 4799 m water depth) that corresponds to its equatorial crossing (caused by the Northward movement of the pacific plate). Green sediment is a visual indicator of reducing conditions in sediment due to enhanced organic matter deposition and burial. Here we use geochemical redox indicators to characterize the effect of equatorial upwelling on bottom water. The modern redox signal is captured in porewater profiles (nitrate, manganese, iron, sulfate) while trace metal Enrichment Factors (EF) in bulk sediment (manganese, uranium, molybdenum, rhenium) normalized to the detrital component (titanium) record redox state at burial. To measure export productivity we also measure biogenic barium. Porewater profiles reveal suboxic diagenesis; profiles follow the expected sequence of nitrate, manganese oxide, and iron oxide reduction with increasing depth. Constant sulfate (~28 μM) implies anoxia has not occurred. Bulk sediment Mn EF are enriched (EF > 1) throughout the record (Mn EF = 15-200) while U and Mo enrichment corresponds to green color and equatorial proximity (U EF = 4-19; Mo EF = 0-7). Constant Mn enrichment implies continuous oxygenation. Uranium and Mo enrichment near the equator represents suboxic conditions also seen in the porewater. Low Re concentrations (below detection) provide additional evidence against anoxia. A comparison of Mn EF from total digestions to samples treated with an additional reductive cleaning step distinguishes between Mn-oxides and Mn-carbonates, indicating oxygenated and reducing conditions respectively. Mn-carbonate occurrence agrees with U and Mo EF; conditions were more reducing near the equator. Bio-Ba shows significant variability over this interval (22-99 mmol g-1). Our geochemical results indicate that bottom waters became suboxic at the equator as a result of equatorial upwelling-influenced increases in organic

  20. Upper ocean circulation modulation by phytoplankton concentration in the Equatorial Pacific and the Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Nakamoto, S.; PrasannaKumar, S.; Oberhuber, J.M.; Sammarco, P.; Muneyama, K.; Sato, T.; AjoyKumar, A.; Frouin, R.

    gradient in the upper ocean. This strengthens the geostrophically balanced westward currents in both side of the equatorial wave-guide (within 5 degree bands). Once these currents reach the western Pacific coast, they feed the Equatorial undercurrent (EUC...

  1. The guinea pig as an animal model for developmental and reproductive toxicology studies.

    Science.gov (United States)

    Rocca, Meredith S; Wehner, Nancy G

    2009-04-01

    Regulatory guidelines for developmental and reproductive toxicology (DART) studies require selection of "relevant" animal models as determined by kinetic, pharmacological, and toxicological data. Traditionally, rats, mice, and rabbits are the preferred animal models for these studies. However, for test articles that are pharmacologically inactive in the traditional animal models, the guinea pig may be a viable option. This choice should not be made lightly, as guinea pigs have many disadvantages compared to the traditional species, including limited historical control data, variability in pregnancy rates, small and variable litter size, long gestation, relative maturity at birth, and difficulty in dosing and breeding. This report describes methods for using guinea pigs in DART studies and provides results of positive and negative controls. Standard study designs and animal husbandry methods were modified to allow mating on the postpartum estrus in fertility studies and were used for producing cohorts of pregnant females for developmental studies. A positive control study with the pregnancy-disrupting agent mifepristone resulted in the anticipated failure of embryo implantation and supported the use of the guinea pig model. Control data for reproductive endpoints collected from 5 studies are presented. In cases where the traditional animal models are not relevant, the guinea pig can be used successfully for DART studies. (c) 2009 Wiley-Liss, Inc.

  2. Ocean dynamics, not dust, have controlled equatorial Pacific productivity over the past 500,000 years

    OpenAIRE

    Winckler, Gisela; Anderson, Robert F.; Jaccard, Samuel L.; Marcantonio, Franco

    2016-01-01

    Biological productivity in the equatorial Pacific is relatively high compared with other low latitude regimes especially east of the dateline where divergence driven by the trade winds brings nutrient rich waters of the Equatorial Undercurrent to the surface. The equatorial Pacific is one of the three principal high nutrient low chlorophyll ocean regimes where biological utilization of nitrate and phosphate is limited in part by the availability of iron. Throughout most of the equatorial Paci...

  3. Development of a Guinea Pig Lung Deposition Model

    Science.gov (United States)

    2016-01-01

    Development of a Guinea Pig Lung Deposition Model Distribution Statement A. Approved for public release; distribution is unlimited. January...4 Figure 2. Particle deposition in the lung of the guinea pig via endotracheal breathing...Particle deposition in the lungs of guinea pigs via nasal breathing. ......................................... 12 v PREFACE The research work

  4. Equatorial E Region Electric Fields and Sporadic E Layer Responses to the Recovery Phase of the November 2004 Geomagnetic Storm

    Science.gov (United States)

    Moro, J.; Resende, L. C. A.; Denardini, C. M.; Xu, J.; Batista, I. S.; Andrioli, V. F.; Carrasco, A. J.; Batista, P. P.; Schuch, N. J.

    2017-12-01

    Equatorial E region electric fields (EEFs) inferred from coherent radar data, sporadic-E (Es) layers observed from a digital ionosonde data, and modeling results are used to study the responses of the equatorial E region over São Luís (SLZ, 2.3°S, 44.2°W, -7° dip angle), Brazil, during the super storm of November 2004. The EEF is presented in terms of the zonal (Ey) and vertical (Ez) components in order to analyze the corresponding characteristics of different types of Es seen in ionograms and simulated with the E region ionospheric model. We bring out the variabilities of Ey and Ez components with storm time changes in the equatorial E region. In addition, some aspects of the electric fields and Es behavior in three cases of weak, very weak, and strong Type II occurrences during the recovery phase of the geomagnetic storm are discussed. The connection between the enhanced occurrence and suppressions of the Type II irregularities and the q-type Es (Esq) controlled by electric fields, with the development or disruption of the blanketing sporadic E (Esb) layers produced by wind shear mechanism, is also presented. The mutual presence of Esq along with the Esb occurrences is a clear indicator of the secular drift of the magnetic equator and hence that of the equatorial electrojet (EEJ) over SLZ. The results show evidence about the EEJ and Es layer electrodynamics and coupling during geomagnetic disturbance time electric fields.

  5. Wild genius - domestic fool? Spatial learning abilities of wild and domestic guinea pigs

    Directory of Open Access Journals (Sweden)

    Sachser Norbert

    2010-03-01

    Full Text Available Abstract Background Domestic animals and their wild relatives differ in a wide variety of aspects. The process of domestication of the domestic guinea pig (Cavia aperea f. porcellus, starting at least 4500 years ago, led to changes in the anatomy, physiology, and behaviour compared with their wild relative, the wild cavy, Cavia aperea. Although domestic guinea pigs are widely used as a laboratory animal, learning and memory capabilities are often disregarded as being very scarce. Even less is known about learning and memory of wild cavies. In this regard, one striking domestic trait is a reduction in relative brain size, which in the domesticated form of the guinea pig amounts to 13%. However, the common belief, that such a reduction of brain size in the course of domestication of different species is accomplished by less learning capabilities is not at all very well established in the literature. Indeed, domestic animals might also even outperform their wild conspecifics taking advantage of their adaptation to a man-made environment. In our study we compared the spatial learning abilities of wild and domestic guinea pigs. We expected that the two forms are different regarding their learning performance possibly related to the process of domestication. Therefore wild cavies as well as domestic guinea pigs of both sexes, aged 35 to 45 days, were tested in the Morris water maze to investigate their ability of spatial learning. Results Both, wild cavies and domestic guinea pigs were able to learn the task, proving the water maze to be a suitable test also for wild cavies. Regarding the speed of learning, male as well as female domestic guinea pigs outperformed their wild conspecifics significantly. Interestingly, only domestic guinea pigs showed a significant spatial association of the platform position, while other effective search strategies were used by wild cavies. Conclusion The results demonstrate that domestic guinea pigs do not at all

  6. Iron sources and pathways into the Pacific Equatorial Undercurrent

    NARCIS (Netherlands)

    Qin, Xuerong; Menviel, Laurie; Sen Gupta, Alex; van Sebille, Erik

    2016-01-01

    Using a novel observationally constrained Lagrangian iron model forced by outputs from an eddy-resolving biogeochemical ocean model, we examine the sensitivity of the Equatorial Undercurrent (EUC) iron distribution to EUC source region iron concentrations. We find that elevated iron concentrations

  7. Equatorial electrojet in the Indian region during the geomagnetic ...

    Indian Academy of Sciences (India)

    1998-11-14

    Nov 14, 1998 ... In the recovery phase of the storm, the electric field due to shielding layer penetrates to equatorial latitudes as an overshielding electric field with opposite polarity, westward during day- side and eastward during night side (Kelley et al. 1979). In addition to the prompt penetration elec- tric fields, there are ...

  8. Climate regulation of fire emissions and deforestation in equatorial Asia

    NARCIS (Netherlands)

    van der Werf, G. R.; Dempewolf, J.; Trigg, S. N.; Randerson, J. T.; Kasibhatla, P. S.; Giglio, L.; Murdiyarso, D.; Peters, W.; Morton, D. C.; Collatz, G. J.; Dolman, A. J.; Defries, R. S.

    2008-01-01

    Drainage of peatlands and deforestation have led to large-scale fires in equatorial Asia, affecting regional air quality and global concentrations of greenhouse gases. Here we used several sources of satellite data with biogeochemical and atmospheric modeling to better understand and constrain fire

  9. Characterisation of tectonic lineaments in the Central Equatorial ...

    African Journals Online (AJOL)

    Characterisation of tectonic lineaments in the Central Equatorial Atlantic region of Africa using Bouguer anomaly gravity data. ... Ife Journal of Science ... 3-D standard Euler deconvolution analysis was carried out on Bouguer anomaly gravity data for configuration definition and approximate depth estimate of tectonic ...

  10. Planktonic foraminifera from core tops of western equatorial Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Naidu, P.D.; Guptha, M.V.S.

    distributional pattern showing upward trend in its abundance from 38 per cent at 21 degrees S latitude to 0.8 per cent at 6 degrees N latitude. Sub-tropical fauna is sparsely distributed in the Equatorial Indian Ocean. Based on these studies it is interpreted...

  11. equatorial electrojet strength in the african sector during high

    African Journals Online (AJOL)

    Preferred Customer

    shown to be consistent with the earlier similar work carried out for the American and ... reference to the quiet day night time level of H, ... February and July, and shifts equator ward to 27°N ... effect of the equatorial electrojet along this line is.

  12. Radar observation of the equatorial counter-electrojet

    International Nuclear Information System (INIS)

    Hanuise, C.; Crochet, M.; Gouin, P.; Ogubazghi, Ghebrebrhan

    1979-01-01

    Electron drift velocity in the equatorial electrojet has been measured for a few years by coherent radar techniques in Africa. For the first time such measurements were performed during a strong reversal of the ionospheric current dubbed 'counter-electrojet'. These observations agree with the theories of the plasma instabilities at the origin of the electron density irregularities giving the radar echoes

  13. Characterization of the effect of penehyclidine hydrochloride on muscarinic receptor subtypes mediating the contraction of guinea-pig isolated gastrointestinal smooth muscle.

    Science.gov (United States)

    Xiao, Hong-Tao; Liao, Zhi; Meng, Xian-Min; Yan, Xiao-Yan; Chen, Shu-Jie; Mo, Zheng-Ji

    2009-07-01

    The aim was to characterize the effect of penehyclidine hydrochloride, which mediates the relaxation of guinea-pig isolated gastrointestinal smooth muscle, on muscarinic receptor subtypes. Radioimmune assay was used to determine cAMP levels in isolated guinea-pig gastrointestinal smooth muscle to compare the selective effects of penehyclidine hydrochloride on muscarinic receptor subtypes. The results indicated that the relaxing effect of penehyclidine hydrochloride on isolated gastrointestinal smooth muscle contraction induced by acetylcholine was stronger than that of atropine (based on PA2 values). In the radioimmune assay, penehyclidine hydrochloride increased the cAMP content in isolated guinea-pig stomach smooth muscle and decreased the cAMP content in isolated guinea-pig intestinal smooth muscle, but the difference was not statistically significant at a dose of 10 mumol/l. The results suggest that penehyclidine hydrochloride has little or no effect on M2 receptor subtypes in guinea-pig gastrointestinal smooth muscle.

  14. Organic sediments of the equatorial east Atlantic: Effects of origin, transport, diagenesis, and climate

    International Nuclear Information System (INIS)

    Westerhausen, L.

    1992-01-01

    The origins and diagenesis of organic matter in recent sediments of the equatorial Eastern Atlantic are assessed on the basis of the 13 C/ 12 C composition of the organic carbon (δ 13 C TOC ), the C/N ratio, and molecular biomarkers from terrigenic and marine sources. Also investigated was the effect of global climate on the 13 C/ 12 C ratios of marine organic carbon and on the origins of organic matter on sedimentary cores. The terrigenic fraction of organic carbon is calculated using a binary δ 13 C TOC mixing model. To begin with, the δ 13 C TOC values were standardized to a uniform surface water temperature and water depth. The calculated terrigenic TOC fractions amount to more than 60% for shelf sediments off the coast of Eastern Liberia, Ivory Coast, and the continental shelf of Gabun. The higher terrigenic TOC fractions of up to 20% in recent sediments on the continental shelf along the coast of Guinea to Ivory Coast are interpreted in terms of a transport of terrigenic substances in down hill direction and parallel to the coast. The effects of the global climate on the TOC accumulation rates and on the 13 C/ 12 C ratio of organic carbon were investigated in a pelogic sedimentary core (M16772) from the tropical Eastern Atlantic. Prior to this, the δ 13 C TOC values were standardized to a uniform surface temperature and a uniform 13 C/ 12 C ratio of the dissolved inorganic carbon using the UK 37 index and the δ 13 C values of G.ruber. During the cold periods the export production increases, which - together with the low CO 2 partial pressure in the atmosphere, and thus also in the surface water -induces 13 C accumulation in the marine organic carbon. There is nothing to suggest an effect of 13 C-accumulating phytoplancton, e.g. dinoflagellats, on the 13 C/ 12 C ratio. (orig./KW). 32 figs., 8 tabs [de

  15. Malignant transformation of guinea pig cells after exposure to ultraviolet-irradiated guinea pig cytomegalovirus

    International Nuclear Information System (INIS)

    Isom, H.C.; Mummaw, J.; Kreider, J.W.

    1983-01-01

    Guinea pig cells were malignantly transformed in vitro by ultraviolet (uv)-irradiated guinea pig cytomegalovirus (GPCMV). When guinea pig hepatocyte monolayers were infected with uv-irradiated GPCMV, three continuous epithelioid cell lines which grew in soft agarose were established. Two independently derived GPCMV-transformed liver cells and a cell line derived from a soft agarose clone of one of these lines induced invasive tumors when inoculated subcutaneously or intraperitoneally into nude mice. The tumors were sarcomas possibly derived from hepatic stroma or sinusoid. Transformed cell lines were also established after infection of guinea pig hepatocyte monolayers with human cytomegalovirus (HCMV) or simian virus 40 (SV40). These cell lines also formed colonies in soft agarose and induced sarcomas in nude mice. It is concluded that (i) GPCMV can malignantly transform guinea pig cells; (ii) cloning of GPCMV-transformed cells in soft agarose produced cells that induced tumors with a shorter latency period but with no alteration in growth rate or final tumor size; and (iii) the tumors produced by GPCMV-and HCMV-transformed guinea pig cells were more similar to each other in growth rate than to those induced by SV40-transformed guinea pig cells

  16. Effect of fructo-oligosaccharide on nitrogen utilization in guinea pigs.

    Science.gov (United States)

    Kawasaki, Kiyonori; Min, Xiao; Nishiyama, Ai; Sakaguchi, Ei

    2013-04-01

    The present study was conducted to determine the effects of fructo-oligosaccharide (FOS) on the nitrogen (N) utilization and digestibilities of dietary nutrients through cecotrophy in guinea pigs. Adult male guinea pigs that were housed or not housed in wooden frames to prevent cecotrophy were fed a commercial pellet diet (50 g/day) with 3% and 5% glucose or FOS for 8 days in individual metabolism cages. In the guinea pigs allowed cecotrophy, addition of FOS to the diet had no significant effects on body weight gain or apparent digestibility of N, but showed significantly lower value for the urinary N excretion and acid-detergent fiber digestibility (P guinea pigs prevented from cecotrophy, FOS had no effect on N retention, but showed tendencies toward a higher value for fecal N excretion and a lower value for urinary N excretion. These results suggest that FOS stimulates cecal microbial proliferation, thereby improving N utilization in guinea pigs. © 2012 Japanese Society of Animal Science.

  17. Effects of Changing to Individually Ventilated Caging on Guinea Pigs (Cavia porcellus).

    Science.gov (United States)

    Giral, Marta; Armengol, Clara; Sánchez-Gómez, Sonia; Gavaldà, Amadeu

    2015-05-01

    The goal of this study was to evaluate the effect of changing to IVC housing on guinea pigs by recording several physiologic parameters in guinea pigs housed sequentially in open-top cages (OTC) and IVC. To register heart rate and locomotor activity, 10 male Dunkin-Hartley guinea pigs implanted with telemetric transmitters were moved from OTC to new, freshly prepared OTC or IVC and subsequently monitored by telemetry during the 4 d after the first cage change. Body weight and food consumption were measured twice during the study. Comparison of data from OTC- and IVC-housed guinea pigs showed no relevant differences in heart rate (mean ± 1 SD; 213 ± 10 bpm and 207 ± 9 bpm, respectively) at any time point. In contrast, locomotor activity varied: whereas activity during the first 4 h after the change of cage type was greater in IVC-housed animals, that during the following 24 h was greater in OTC but was similar between groups thereafter. Animals housed in OTC consumed more food than did those in IVC and, under both conditions, consumption was statistically related to body weight changes. Together, these results show that a change to IVC housing induced only transient increases in locomotor activity in guinea pigs without a marked increase in heart rate but with a decrease in food consumption. Because decreased food consumption was the only stress-associated sign during the 4-d observation, longer studies are needed to ascertain the importance of this finding.

  18. Spontaneous occurrence of a potentially night blinding disorder in guinea pigs.

    Science.gov (United States)

    Racine, Julie; Behn, Darren; Simard, Eric; Lachapelle, Pierre

    2003-07-01

    Several hereditary retinal disorders such as retinitis pigmentosa and congenital stationary night blindness compromise, sometimes exclusively, the activity of the rod pathway. Unfortunately, there are few animal models of these disorders that could help us better understand the pathophysiological processes involved. The purpose of this report is to present a pedigree of guinea pigs where, as a result of a consanguineous mating and subsequent selective breeding, we developed a new and naturally occurring animal model of a rod disorder. Analysis of the retinal function with the electroretinogram reveals that the threshold for rod-mediated electroretinograms (ERGs) is significantly increased by more than 2 log-units compared to that of normal guinea pigs. Furthermore, in response to a suprathreshold stimulus, also delivered under scotopic condition, which yield a mixed cone-rod response in normal guinea pigs, the ERG waveform in our mutant guinea pigs is almost identical (amplitude and timing of a- and b-waves) to that evoked in photopic condition. The above would thus suggest either a structural (abnormal development or absence) or a functional deficiency of the rod photoreceptors. We believe that our pedigree possibly represents a new animal model of a night blinding disorder, and that this condition is inherited as anautosomal recessive trait in the guinea pig population.

  19. The gastrointestinal absorption and retention of niobium in adult and newborn guinea pigs

    International Nuclear Information System (INIS)

    Harrison, J.D.; Haines, J.W.; Popplewell, D.S.

    1990-01-01

    The gastrointestinal absorption of 95 Nb ingested in milk by adult guinea pigs on a milk-supplemented diet was estimated as 0.8±0.2% (SEM; n=4) and a value of 1.4±0.2% obtained for guinea pigs fasted for 24 h before and 2 h after oral administration of 95 Nb in a citrate solution. The absorption in 2-day-old animals given the 95 Nb-citrate solution was estimated as 1.5±0.2% (SEM; n=3). These results support the values currently used for radiological protection purposes to calculate doses from the ingestion of niobium isotopes; these are 1% for adults and 2% for infants in the first year of life. Intestinal retention of niobium in newborn guinea pigs was low, unlike retention in other species, but consistent with observations of the retention of other elements in guinea pigs. It is considered that retention in human neonates is likely to be most similar to that in guinea pigs. (author)

  20. Levels of protein hydroperoxides and carbonyl groups in guinea pigs native of high altitudes (Huancavelica, 3660 m)

    OpenAIRE

    Huayta, Roxana; Zúñiga, Haydée; Esquerre, Cynthia; Hernández, Luz; Carranza, Elizabeth

    2014-01-01

    The influence of hypobaric hypoxia on protein oxidation in lungs, heart, liver, kidneys and testicles of high altitude native guinea pigs (Huancavelica, 3660 m) in comparison to sea level (Lima, 150 m) native guinea pigs was evaluated. The concentration of protein hydroperoxides (POOH) and carbonyl groups (GC) as markers of protein oxidation, as well as total thiols (TT) concentration, powerful reducing agents that act as live antioxidants were determined. The results showed low concentration...

  1. Oxidative DNA damage in vitamin C-supplemented guinea pigs after intratracheal instillation of diesel exhaust particles

    DEFF Research Database (Denmark)

    Moller, P.; Daneshvar, B.; Loft, S.

    2003-01-01

    . The concentrations of ascorbate in liver, lung, and plasma were unaltered by the DEP exposure. The results indicate that in guinea pigs DEP causes oxidative DNA damage rather than bulky DNA adducts in the lung. Guinea pigs, which are similar to humans with respect to vitamin C metabolism, may serve as a new model...... for the study of oxidative damage induced by particulate matter. (C) 2003 Elsevier Science (USA). All rights reserved....

  2. Determination of stimulation effective dose of gamma ray on guinea pig to be used for antibody production

    International Nuclear Information System (INIS)

    Arifin, Muchson; Soewarsono, M.

    1983-01-01

    The experiment has been performed on guinea pigs which were irradiated by gamma rays with doses of 0, 150, 300 and 600 rad. Observations were carried out on peripheral blood in regard to red blood cell, white blood cell and haemoglobine, every week after irradiation. +he result obtained showed that 150 rad was the optimal stimulation effective dose for antibody production in guinea pigs. (author)

  3. Determination of stimulation effective dose of gamma ray on guinea pig to be used for antibody production

    Energy Technology Data Exchange (ETDEWEB)

    Arifin, M; Soewarsono, M [National Atomic Energy Agency, Jakarta (Indonesia). Pasar Djumat Research Centre

    1983-04-01

    The experiment has been performed on guinea pigs which were irradiated by gamma rays with doses of 0, 150, 300 and 600 rad. Observations were carried out on peripheral blood in regard to red blood cell, white blood cell and haemoglobine, every week after irradiation. The result obtained showed that 150 rad was the optimal stimulation effective dose for antibody production in guinea pigs. 10 refs.

  4. Post-midnight occurrence of equatorial plasma bubbles

    Science.gov (United States)

    Ajith, K. K.; Otsuka, Yuichi; Yamamoto, Mamoru; Yokoyama, Tatsuhiro; Tulasiram, S.

    2016-07-01

    The equatorial plasma bubbles (EPBs)/equatorial spread F (ESF) irregularities are an important topic of space weather interest because of their impact on transionospheric radio communications, satellite-based navigation and augmentation systems. This local plasma depleted structures develop at the bottom side F layer through Rayleigh-Taylor instability and rapidly grow to topside ionosphere via polarization electric fields within them. The steep vertical gradients due to quick loss of bottom side ionization and rapid uplift of equatorial F layer via prereversal enhancement (PRE) of zonal electric field makes the post-sunset hours as the most preferred local time for the formation of EPBs. However, there is a different class of irregularities that occurs during the post-midnight hours of June solstice reported by the previous studies. The occurrence of these post-midnight EPBs maximize during the low solar activity periods. The growth characteristics and the responsible mechanism for the formation of these post-midnight EPBs are not yet understood. Using the rapid beam steering ability of 47 MHz Equatorial Atmosphere Radar (EAR) at Kototabang (0.2°S geographic latitude, 100.3°E geographic longitude, and 10.4°S geomagnetic latitude), Indonesia, the spatial and temporal evolution of equatorial plasma bubbles (EPBs) were examined to classify the evolutionary-type EPBs from those which formed elsewhere and drifted into the field of view of radar. The responsible mechanism for the genesis of summer time post-midnight EPBs were discussed in light of growth rate of Rayleigh-Taylor instability using SAMI2 model.

  5. Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig

    Energy Technology Data Exchange (ETDEWEB)

    Nakashima, Y; Sanada, H; Suzue, R; Kawada, S [National Inst. of Nutrition, Tokyo (Japan)

    1976-10-01

    The decrease of tyrosine hydroxylase activity in adrenal homogenate in scurvy was recovered after the administration of ascorbic acid. The causes of the increase in the enzyme activity after the administration of ascorbic acid have been studied. 1. No significant elevation in the enzyme activity was observed after the administration of reserpine to the scorbutic guinea pig. 2. A dose of metal chelating agent, ..cap alpha.., ..cap alpha..'-dipyridyl, prevented the ascorbic acid-induced or reserpine-induced increase in enzyme activity in the scorbutic and the nonscorbutic guinea pigs, respectively. 3. Tyrosine hydroxylase activity was partially recovered by the administration of FeSO/sub 4/ to the scorbutic guinea pig. From these results, it became clear that the induction of tyrosine hydroxylase which was not observed in scurvy was due to the deficiency of Fe/sup 2 +/. These results suggested that ascorbic acid affected the induction of this enzyme via Fe/sup 2 +/.

  6. Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig

    International Nuclear Information System (INIS)

    Nakashima, Yoko; Sanada, Hiroo; Suzue, Ryokuero; Kawada, Shoji

    1976-01-01

    The decrease of tyrosine hydroxylase activity in adrenal homogenate in scurvy was recovered after the administration of ascorbic acid. The causes of the increase in the enzyme activity after the administration of ascorbic acid have been studied. 1. No significant elevation in the enzyme activity was observed after the administration of reserpine to the scorbutic guinea pig. 2. A dose of metal chelating agent, α, α'-dipyridyl, prevented the ascorbic acid-induced or reserpine-induced increase in enzyme activity in the scorbutic and the nonscorbutic guinea pigs, respectively. 3. Tyrosine hydroxylase activity was partially recovered by the administration of FeSO 4 to the scorbutic guinea pig. From these results, it became clear that the induction of tyrosine hydroxylase which was not observed in scurvy was due to the deficiency of Fe 2+ . These results suggested that ascorbic acid affected the induction of this enzyme via Fe 2+ . (auth.)

  7. Wild genius - domestic fool? Spatial learning abilities of wild and domestic guinea pigs.

    Science.gov (United States)

    Lewejohann, Lars; Pickel, Thorsten; Sachser, Norbert; Kaiser, Sylvia

    2010-03-25

    Domestic animals and their wild relatives differ in a wide variety of aspects. The process of domestication of the domestic guinea pig (Cavia aperea f. porcellus), starting at least 4500 years ago, led to changes in the anatomy, physiology, and behaviour compared with their wild relative, the wild cavy, Cavia aperea. Although domestic guinea pigs are widely used as a laboratory animal, learning and memory capabilities are often disregarded as being very scarce. Even less is known about learning and memory of wild cavies. In this regard, one striking domestic trait is a reduction in relative brain size, which in the domesticated form of the guinea pig amounts to 13%. However, the common belief, that such a reduction of brain size in the course of domestication of different species is accomplished by less learning capabilities is not at all very well established in the literature. Indeed, domestic animals might also even outperform their wild conspecifics taking advantage of their adaptation to a man-made environment.In our study we compared the spatial learning abilities of wild and domestic guinea pigs. We expected that the two forms are different regarding their learning performance possibly related to the process of domestication. Therefore wild cavies as well as domestic guinea pigs of both sexes, aged 35 to 45 days, were tested in the Morris water maze to investigate their ability of spatial learning. Both, wild cavies and domestic guinea pigs were able to learn the task, proving the water maze to be a suitable test also for wild cavies. Regarding the speed of learning, male as well as female domestic guinea pigs outperformed their wild conspecifics significantly. Interestingly, only domestic guinea pigs showed a significant spatial association of the platform position, while other effective search strategies were used by wild cavies. The results demonstrate that domestic guinea pigs do not at all perform worse than their wild relatives in tests of spatial

  8. Effects of intranasal corticosteroids on radiated nasal mucosa of guinea pig

    International Nuclear Information System (INIS)

    Zhu Xinhua; Liu Yuehui

    2009-01-01

    Objective: To investigate a mechanism protected radiation-induce injure for radiated guinea pigs'nasal mucosa treated with intranasal corticosteroids(fluticasone nasal cavity spray). Methods: 50 health guinea pigs were divided into 2 groups randomly: the irradiated group (control group) with 25 guinea pigs and the administration group after irradiation (test group)with 25 guinea pigs. The nasal part of all guinea pigs were performed irradiation by the 6 MV X-ray with single 5 Gy, one time each week for three weeks. The guinea pigs of test group received intranasal corticosteroids with one time every day and one spray each side nasal cavity on the second day after three weeks irradiation. Five guinea pigs in each group were sacrificed randomly at 1 week, 1 month, 2 months, 3 months and 4 months after irradiation, and the histopathologic changes were observed under optical microscope and electron microscope. At the same time, blood were drawn from the heart and the concentration of IL-1, IL-6 and TNF-α in serum were measured by ELISA. Results: The early nasal mucosa inflammatory reaction of the test group was less than the control group. The coverage rate of cilia of the test group was much than that of the control group (72.9% vs 50.2%) at four months after irradiation. The atrophy of submucosal glandular organ was lessened and they displayed some extent secretory function. The concentration of IL-1 in serum was increased very much in the test group compared with the control group after irradiation and kept higher level in the first two months. After two months, it began to decrease; on four months, it still kept equivalency level with the control group. The concentration of IL-6 and TNF-α in serum were reduced all the while. Conclusions: The intranasal corticosteroids with fluticasone nasal cavity spray can reduce radiation- induced injury of guinea pigs' nasal mucosa. The concentration change of IL-1, IL-6 and TNF-α in serum may be one of mechanism protected

  9. Isolation and characterisation of a dinucleotide microsatellite set for a parentage and biodiversity study in domestic guinea pig (Cavia porcellus

    Directory of Open Access Journals (Sweden)

    Diana Aviles

    2015-10-01

    Full Text Available The domestic guinea pig is a valuable genetic resource because it is part of local folklore and food tradition in many South American countries. The economic importance of the guinea pig is due to its high feed efficiency and the quality of animal protein produced. For these reasons, our study is aimed to design a complete dinucleotide microsatellite marker set following international recommendation to assess the genetic diversity and genealogy management of guinea pigs. We selected a total of 20 microsatellites, looking for laboratory efficiency and good statistical parameters. The set was tested in 100 unrelated individuals of guinea pigs from Ecuador, Peru, Colombia, Bolivia and Spain. Our results show a high degree of polymorphisms with a total of 216 alleles and a mean number of 10.80±3.49 for markers with a combined exclusion probability of 0.99.

  10. Lack of effect of ivermectin on prepatent guinea-worm

    DEFF Research Database (Denmark)

    Issaka-Tinorgah, A.; Magnussen, P.; Bloch, P.

    1994-01-01

    The effect of ivermectin on prepatent guinea-worm was tested in a single-blind placebo-controlled trial; 400 adults were randomly allocated to a single dose of ivermectin (150 µg/kg) or placebo. Fifty-four of the 385 participants who were followed for 15 months developed a total of 69 emergent...... guinea-worms. There was no significant differencein the proportion of persons with emergent guinea-worms between the 2 treatment groups; 58% appeared in males. 80% of emergent guinea-worms were located below the knee. Migration of guinea-worms in the tissues was not affected. It is concluded...

  11. Coral settlement on a highly disturbed equatorial reef system.

    Science.gov (United States)

    Bauman, Andrew G; Guest, James R; Dunshea, Glenn; Low, Jeffery; Todd, Peter A; Steinberg, Peter D

    2015-01-01

    Processes occurring early in the life stages of corals can greatly influence the demography of coral populations, and successful settlement of coral larvae that leads to recruitment is a critical life history stage for coral reef ecosystems. Although corals in Singapore persist in one the world's most anthropogenically impacted reef systems, our understanding of the role of coral settlement in the persistence of coral communities in Singapore remains limited. Spatial and temporal patterns of coral settlement were examined at 7 sites in the southern islands of Singapore, using settlement tiles deployed and collected every 3 months from 2011 to 2013. Settlement occurred year round, but varied significantly across time and space. Annual coral settlement was low (~54.72 spat m(-2) yr(-1)) relative to other equatorial regions, but there was evidence of temporal variation in settlement rates. Peak settlement occurred between March-May and September-November, coinciding with annual coral spawning periods (March-April and October), while the lowest settlement occurred from December-February during the northeast monsoon. A period of high settlement was also observed between June and August in the first year (2011/12), possibly due to some species spawning outside predicted spawning periods, larvae settling from other locations or extended larval settlement competency periods. Settlement rates varied significantly among sites, but spatial variation was relatively consistent between years, suggesting the strong effects of local coral assemblages or environmental conditions. Pocilloporidae were the most abundant coral spat (83.6%), while Poritidae comprised only 6% of the spat, and Acroporidae coral spat. These results indicate that current settlement patterns are reinforcing the local adult assemblage structure ('others'; i.e. sediment-tolerant coral taxa) in Singapore, but that the replenishment capacity of Singapore's reefs appears relatively constrained, which could lead

  12. Ocean Color and the Equatorial Annual Cycle in the Pacific

    Science.gov (United States)

    Hammann, A. C.; Gnanadesikan, A.

    2012-12-01

    The presence of chlorophyll, colored dissolved organic matter (CDOM) and other scatterers in ocean surface waters affect the flux divergence of solar radiation and thus the vertical distribution of radiant heating of the ocean. While this may directly alter the local mixed-layer depth and temperature (Martin 1985; Strutton & Chavez 2004), non-local changes are propagated through advection (Manizza et al. 2005; Murtugudde et al. 2002; Nakamoto et al. 2001; Sweeny et al. 2005). In and coupled feedbacks (Lengaigne et al. 2007; Marzeion & Timmermann 2005). Anderson et al. (2007), Anderson et al. (2009) and Gnanadesikan & Anderson (2009) have performed a series of experiments with a fully coupled climate model which parameterizes the e-folding depth of solar irradiance in terms of surface chlorophyll-a concentration. The results have so far been discussed with respect to the climatic mean state and ENSO variability in the tropical Pacific. We extend the discussion here to the Pacific equatorial annual cycle. The focus of the coupled experiments has been the sensitivity of the coupled system to regional differences in chlorophyll concentration. While runs have been completed with realistic SeaWiFS-derived monthly composite chlorophyll ('green') and with a globally chlorophyll-free ocean ('blue'), the concentrations in two additional runs have been selectively set to zero in specific regions: the oligotrophic subtropical gyres ('gyre') in one case and the mesotrophic gyre margins ('margin') in the other. The annual cycle of ocean temperatures exhibits distinctly reduced amplitudes in the 'blue' and 'margin' experiments, and a slight reduction in 'gyre' (while ENSO variability almost vanishes in 'blue' and 'gyre', but amplifies in 'margin' - thus the frequently quoted inverse correlation between ENSO and annual amplitudes holds only for the 'green' / 'margin' comparison). It is well-known that on annual time scales, the anomalous divergence of surface currents and vertical

  13. Nonlinear oscillation regime of electromagnetic disturbances in the equatorial F region

    International Nuclear Information System (INIS)

    Sazonov, S.V.

    1990-01-01

    Nonlinear oscillation regime of electromagnetic dicturbances within equatorial ionosphere F-region resulted from Rayleigh-Taylor instability, gradient-drift instability and recombination processes is investigated on the basis of two-liquid quasihydrodynamics equations. It is shown, that at positive linear increment the oscillations are developing in regime with aggregation and are terminated by increment the effect of threshold destabilization, when under certain initial conditions underlgoes oscillation nonlinear swinging, resulting, as well, in bubble formation in contrast to small damping oscillations, is detected

  14. Inhibition of gastric secretion in guinea pig by relatively low dose ionizing radiation

    International Nuclear Information System (INIS)

    Batzri, S.; Catravas, G.

    1988-01-01

    We evaluated the effect of a single dose of ionizing radiation on gastric secretion in awake guinea pigs equipped with a permanent gastric cannula. Changes in gastric secretion were measured using a dye dilution technique. Infusion of histamine increased acid and fluid output and there was a positive correlation (r = 0.93) between the two. Total body irradiation with 400 cGy, like cimetidine, suppressed acid and fluid secretion under basal conditions and during histamine stimulation by 50-90%. Recovery from the radiation damage was only partial after one week. Irradiation inhibited the rise in gastric juice volume during histamine stimulation and also reduced the normal gain in body weight of the guinea pig. These results demonstrate that ionizing radiations have an immediate and long lasting effects on the gastric mucosal function of the guinea pig

  15. Prolactin family of the guinea pig, Cavia porcellus.

    Science.gov (United States)

    Alam, S M Khorshed; Konno, Toshihiro; Rumi, M A Karim; Dong, Yafeng; Weiner, Carl P; Soares, Michael J

    2010-08-01

    Prolactin (PRL) is a multifunctional hormone with prominent roles in regulating growth and reproduction. The guinea pig (Cavia porcellus) has been extensively used in endocrine and reproduction research. Thus far, the PRL cDNA and protein have not been isolated from the guinea pig. In the present study, we used information derived from the public guinea pig genome database as a tool for identifying guinea pig PRL and PRL-related proteins. Guinea pig PRL exhibits prominent nucleotide and amino acid sequence differences when compared with PRLs of other eutherian mammals. In contrast, guinea pig GH is highly conserved. Expression of PRL and GH in the guinea pig is prominent in the anterior pituitary, similar to known expression patterns of PRL and GH for other species. Two additional guinea pig cDNAs were identified and termed PRL-related proteins (PRLRP1, PRLRP2). They exhibited a more distant relationship to PRL and their expression was restricted to the placenta. Recombinant guinea pig PRL protein was generated and shown to be biologically active in the PRL-responsive Nb2 lymphoma cell bioassay. In contrast, recombinant guinea pig PRLRP1 protein did not exhibit PRL-like bioactivity. In summary, we have developed a new set of research tools for investigating the biology of the PRL family in an important animal model, the guinea pig.

  16. Role of the magnetospheric and ionospheric currents in the generation of the equatorial scintillations during geomagnetic storms

    Directory of Open Access Journals (Sweden)

    L. Z. Biktash

    2004-09-01

    Full Text Available The equatorial ionosphere parameters, Kp, Dst, AU and AL indices characterized contribution of different magnetospheric and ionospheric currents to the H-component of geomagnetic field are examined to test the geomagnetic activity effect on the generation of ionospheric irregularities producing VLF scintillations. According to the results of the current statistical studies, one can predict near 70% of scintillations from Aarons' criteria using the Dst index, which mainly depicts the magnetospheric ring current field. To amplify Aarons' criteria or to propose new criteria for predicting scintillation characteristics is the question. In the present phase of the experimental investigations of electron density irregularities in the ionosphere new ways are opened up because observations in the interaction between the solar wind - magnetosphere - ionosphere during magnetic storms have progressed greatly. According to present view, the intensity of the electric fields and currents at the polar regions, as well as the magnetospheric ring current intensity, are strongly dependent on the variations of the interplanetary magnetic field. The magnetospheric ring current cannot directly penetrate the equatorial ionosphere and because of this difficulties emerge in explaining its relation to scintillation activity. On the other hand, the equatorial scintillations can be observed in the absence of the magnetospheric ring current. It is shown that in addition to Aarons' criteria for the prediction of the ionospheric scintillations, models can be used to explain the relationship between the equatorial ionospheric parameters, h'F, foF2, and the equatorial geomagnetic variations with the polar ionosphere currents and the solar wind.

  17. Evidence for a non-opioid sigma binding site din the guinea-pig myenteric plexus

    International Nuclear Information System (INIS)

    Roman, F.; Pascaud, X.; Vauche, D.; Junien, J.

    1988-01-01

    The presence of a binding site to (+)-( 3 H)SKF 10,047 was demonstrated in a guinea-pig myenteric plexus (MYP) membrane preparation. Specific binding to this receptor was saturable, reversible, linear with protein concentration and consisted of two components, a high affinity site and a low affinity site. Morphine and naloxone 10 -4 M were unable to displace (+)-( 3 H)SKF 10,047 binding. Haloperidol, imipramine, ethylketocyclazocine and propranolol were among the most potent compounds to inhibit this specific binding. These results suggest the presence of a non-opioid haloperidol sensitive sigma receptor in the MYP of the guinea-pig

  18. Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs.

    Science.gov (United States)

    Yang, Susan Q; DeGuire, Jason R; Lavery, Paula; Mak, Ivy L; Weiler, Hope A; Santosa, Sylvia

    2016-05-01

    We hypothesize that conjugated linoleic acid (CLA) may be effective in preventing the changes in total and regional body composition and increases in interleukin (IL) 6 that occur as a result of hypogonadism. Male guinea pigs (n = 40, 70- to 72-week retired breeders) were block randomized by weight into 4 groups: (1) sham surgery (SHAM)/control (CTRL) diet, (2) SHAM/conjugated linoleic acid (CLA) diet (1%), (3) orchidectomy (ORX)/CTRL diet, and (4) ORX/CLA diet. Dual-energy x-ray absorptiometry scans were performed at baseline and week 16 to assess body composition. Serum IL-6 was analyzed using an enzyme-linked immune sorbent assay. Fatty acids (FAs) from visceral and subcutaneous adipose tissue were analyzed using gas chromatography. In ORX/CTRL guinea pigs, percent total body fat increased by 6.1%, and percent lean mass decreased by 6.7% over the 16-week treatment period, whereas no changes were observed for either parameter in ORX/CLA guinea pigs. Guinea pigs fed the CLA diet gained less percent total, upper, and lower body fat than those fed the CTRL diet regardless of surgical treatment. Regional adipose tissue FA composition was reflective of dietary FAs. Serum IL-6 concentrations were not different among groups. In this study, we observed that, in male guinea pigs, hypogonadism resulted in increased fat mass and decreased lean mass. In addition, CLA was effective in reducing gains in body fat and maintaining lean mass in both hypogonadal and intact guinea pigs. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Mechanism of resveratrol-induced relaxation of the guinea pig fundus.

    Science.gov (United States)

    Tsai, Ching-Chung; Tey, Shu-Leei; Lee, Ming-Che; Liu, Ching-Wen; Su, Yu-Tsun; Huang, Shih-Che

    2018-04-01

    Resveratrol is a polyphenolic compound that can be isolated from plants and also is a constituent of red wine. Resveratrol induces relaxation of vascular smooth muscle and may prevent cardiovascular diseases. Impaired gastric accommodation plays an important role in functional dyspepsia and fundic relaxation and is a therapeutic target of functional dyspepsia. Although drugs for fundic relaxation have been developed, these types of drugs are still rare. The purpose of this study was to investigate the relaxant effects of resveratrol in the guinea pig fundus. We studied the relaxant effects of resveratrol in the guinea pig fundus. In addition, we investigated the mechanism of resveratrol-induced relaxation on the guinea pig fundus by using tetraethylammonium (a non-selective potassium channel blocker), apamine (a selective inhibitor of the small conductance calcium-activated potassium channel), iberiotoxin (an inhibitor of large conductance calcium-activated potassium channels), glibenclamide (an ATP-sensitive potassium channel blocker), KT 5720 (a cAMP-dependent protein kinase A inhibitor), KT 5823 (a cGMP-dependent protein kinase G inhibitor), NG-nitro-L-arginine (a competitive inhibitor of nitric oxide synthase), tetrodotoxin (a selective neuronal Na + channel blocker), ω-conotoxin GVIA (a selective neuronal Ca 2+ channel blocker) and G-15 (a G-protein coupled estrogen receptor antagonist). The results of this study showed that resveratrol has potent and dose-dependent relaxant effects on the guinea pig fundic muscle. In addition, the results showed that resveratrol-induced relaxation of the guinea pig fundus occurs through nitric oxide and ATP-sensitive potassium channels. This study provides the first evidence concerning the relaxant effects of resveratrol in the guinea pig fundic muscle strips. Furthermore, resveratrol may be a potential drug to relieve gastrointestinal dyspepsia. Copyright © 2018 Elsevier GmbH. All rights reserved.

  20. Prostaglandin release from in vitro guinea-pig gallbladder.

    Science.gov (United States)

    Booker, M L; LaMorte, W W

    1983-02-01

    In order to study prostaglandin release from guinea pig gallbladder, full thickness tissue sections were incubated for one hour in Krebs solution. Extraction and two dimensional chromatography of incubation media obtained in the presence of radio-labelled arachidonic acid demonstrated the presence of PGE2, PGF2 alpha, 6-keto-PGF1 alpha and thromboxane B2. These results were supported by radioimmunoassay of incubations conducted in the absence of exogenous arachidonate and in the presence of varying concentrations of unlabelled exogenous arachidonate. The previously reported predominance of PGE2 was only seen at high concentrations of exogenous arachidonate.

  1. Helicopter-supported drilling operation in Papua New Guinea

    International Nuclear Information System (INIS)

    Wagner, E.R.; Juneau, M.S.

    1991-01-01

    This paper reports on drilling cost per foot of Chevron's helilift drilling operation in the remote Southern Highlands of Papua New Guinea, reduced from 1360 to 267 S/ft (4462 to 876$/m) during the period from 1985 to 1989. The operation provides many challenges, as it is thousands of miles from major oil-field supply centers. This requires advanced will-planning and logistical management of drilling materials so that they arrive at the drilling rig in a timely manner. The wells are also drilled into structurally complex geology without the aid of seismic data which can lead to unexpected results

  2. Global mode of Pi2 waves in the equatorial region

    International Nuclear Information System (INIS)

    Kitamura, Tai-ichi; Saka, Ousuke; Shimoizumi, Masashi

    1988-01-01

    Fluxgate magnetometers with accurate timing data logger were set up at two equatorial stations (Garous-Marous and Huancayo), and also at a middle latitude station (Kuju). The phase of Pi2 waves is compared among these stations. It is found that 1) Pi2 pulsations in low and equatorial latitudes are linearly polarized approximately along the magnetic meridian, 2) phase difference of the H component of Pi2 waves at different stations is much less than 1 - 10 of the pulsation period despite a large longitudinal separation (∼ 90 deg) of the stations, showing the so-called azimuthal wave number, m, to be much less than unity and 3) phase difference of the D component at different stations is variable. (author)

  3. Bottomside sinusoidal irregularities in the equatorial F region

    Science.gov (United States)

    Valladares, C. E.; Hanson, W. B.; Mcclure, J. P.; Cragin, B. L.

    1983-01-01

    By using the Ogo 6 satellite, McClure and Hanson (1973) have discovered sinusoidal irregularities in the equatorial F region ion number density. In the present investigation, a description is provided of the properties of a distinct category of sinusoidal irregularities found in equatorial data from the AE-C and AE-E satellites. The observed scale sizes vary from about 300 m to 3 km in the direction perpendicular to B, overlapping with and extending the range observed by using Ogo 6. Attention is given to low and high resolution data, a comparison with Huancayo ionograms, the confinement of 'bottomside sinusoidal' (BSS) irregularities essentially to the bottomside of the F layer, spectral characteristics, and BSS, scintillation, and ionosonde observations.

  4. Nonlinearly coupled dynamics of irregularities in the equatorial electrojet

    Energy Technology Data Exchange (ETDEWEB)

    Atul, J.K., E-mail: jkatulphysics@gmail.com [Department of Physics, College of Commerce under Magadh University, Patna 800020 (India); Sarkar, S. [FCIPT, Institute for Plasma Research, Gandhinagar 382428 (India); Singh, S.K. [Department of Physics, College of Commerce under Magadh University, Patna 800020 (India)

    2016-04-01

    Kinetic wave description is used to study the nonlinear influence of background Farley Buneman (FB) modes on the Gradient Drift (GD) modes in the equatorial electrojet ionosphere. The dominant nonlinearity is mediated through the electron flux term in the governing fluid equation which further invokes a turbulent current into the system. Electron dynamics reveals the modification in electron collision frequency and inhomogeneity scale length. It is seen that the propagation and growth rate of GD modes get modified by the background FB modes. Also, a new quasimode gets excited through the quadratic dispersion relation. Physical significance of coupled dynamics between the participating modes is also discussed. - Highlights: • Nonlinear influence of Farley Buneman mode on the Gradient drift mode, is investigated. • Electron collision frequency and density gradient scale length get modified. • A new quasimode gets excited due to the competition between these modes. • It seems to be important for modelling of Equatorial Electrojet current system.

  5. Equatorial enhancement of the nighttime OH mesospheric infrared airglow

    International Nuclear Information System (INIS)

    Baker, D J; Thurgood, B K; Harrison, W K; Mlynczak, M G; Russell, J M

    2007-01-01

    Global measurements of the hydroxyl mesospheric airglow over an extended period of time have been made possible by the NASA SABER infrared sensor aboard the TIMED satellite which has been functioning since December of 2001. The orbital mission has continued over a significant portion of a solar cycle. Experimental data from SABER for several years have exhibited equatorial enhancements of the nighttime mesospheric OH (Δv=2) airglow layer consistent with the high average diurnal solar flux. The brightening of the OH airglow typically means more H+O 3 is being reacted. At both the spring and autumn seasonal equinoxes when the equatorial solar UV irradiance mean is greatest, the peak volume emission rate (VER) of the nighttime Meinel infrared airglow typically appears to be both significantly brighter plus lower in altitude by several kilometres at low latitudes compared with midlatitude findings

  6. Nonlinearly coupled dynamics of irregularities in the equatorial electrojet

    International Nuclear Information System (INIS)

    Atul, J.K.; Sarkar, S.; Singh, S.K.

    2016-01-01

    Kinetic wave description is used to study the nonlinear influence of background Farley Buneman (FB) modes on the Gradient Drift (GD) modes in the equatorial electrojet ionosphere. The dominant nonlinearity is mediated through the electron flux term in the governing fluid equation which further invokes a turbulent current into the system. Electron dynamics reveals the modification in electron collision frequency and inhomogeneity scale length. It is seen that the propagation and growth rate of GD modes get modified by the background FB modes. Also, a new quasimode gets excited through the quadratic dispersion relation. Physical significance of coupled dynamics between the participating modes is also discussed. - Highlights: • Nonlinear influence of Farley Buneman mode on the Gradient drift mode, is investigated. • Electron collision frequency and density gradient scale length get modified. • A new quasimode gets excited due to the competition between these modes. • It seems to be important for modelling of Equatorial Electrojet current system.

  7. Picture Communication in Papua New Guinea.

    Science.gov (United States)

    Cook, Bruce L.

    1980-01-01

    Reports the major findings of a study that investigated the effectiveness of using pictures of different art styles (stick figures, faceless outline drawings, detailed black-and-white, detailed black-and-white with watercolor wash, and black-and-white photographs) with 423 new readers in Papua New Guinea. (JD)

  8. The Papua and New Guinea Herbarium

    NARCIS (Netherlands)

    Womersley, J.S.; Botanist, Forest

    1951-01-01

    A short account of the establishment of the Herbarium of the Department of Forests, Papua and New Guinea appeared on p. 61, no 3, volume I of Flora Malesiana Bulletin. This Herbarium has now been firmly established and is constantly receiving collections of plants from various parts of Papua and New

  9. Piraatlus Guinea lahes ja Nigeerias / Eero Tepp

    Index Scriptorium Estoniae

    Tepp, Eero

    2013-01-01

    Guinea lahes lokkava piraatluse põhjused ja tegurid, mis seda soodustavad: seaduselüngad, looduslikud tingimused, ebapädev korrakaitse, poliitiline olustik, kultuuriline vastuvõetavus, majanduslik tasuvus. Sõjalised ja mittesõjalised meetmetest, mida rakendatakse piraatlusevastases võitluses

  10. Iinformation accessibility and farmers manageriability of guinea ...

    African Journals Online (AJOL)

    The study examined the farmers' access to information and their manageriability of the intervention programme in the study area. To achieve the objective, there was need to determine farmers' information accessibility and manageriability of guinea worm intervention package; then determine farmers satisfaction with the ...

  11. Magnetic activity effect on equatorial spread-F under high and low solar activity conditions

    Energy Technology Data Exchange (ETDEWEB)

    Subbarao, K S.V.; Somayajulu, V V; Krishna Murthy, B V

    1986-08-01

    The effect of magnetic activity on spread-F at two equatorial stations, Trivandrum and Huancayo, separated in longitude by about 150 deg, under high and low solar activity conditions has been investigated. Magnetic activity produces strong inhibition effect on spread-F at Huancayo compared to that at Trivandrum especially during high solar activity period. This results in a decrease of spread-F with solar activity at Huancayo in contrast to Trivandrum. These findings are explained in terms of F-region electrodynamics and Rayleigh-Taylor instability mechanism for spread-F.

  12. Wideband satellite phase coherent beacon observations at auroral and equatorial latitudes - A review

    International Nuclear Information System (INIS)

    Rino, C.L.; Livingston, R.C.; Cousins, M.D.; Fair, B.C.

    1978-01-01

    This paper presents a brief review of some of the principal results from the first two years of operation of the Wideband satellite which transmits phase-coherent signals from S-band to VHF. The auroral zone data show narrow regions of enhanced scintillation well equatorward of the discrete aurora. Such enhancements can be explained as a purely geometrical effect if the irregularities within the major precipitation regions have a sheet-like structure. Evidence of a localized irregularity source at the poleward boundary of the plasma trough is also found. Model computations are discussed and applied to the interpretation of equatorial data

  13. Blow-up of solutions to the rotation b-family system modeling equatorial water waves

    Directory of Open Access Journals (Sweden)

    Min Zhu

    2018-03-01

    Full Text Available We consider the blow-up mechanism to the periodic generalized rotation b-family system (R-b-family system. This model can be derived from the f-plane governing equations for the geographical water waves with a constant underlying current in the equatorial water waves with effect of the Coriolis force. When b=2, it is a rotation two-component Camassa-Holm (R2CH system. We consider the periodic R2CH system when linear dispersion is absent (which model is called r2CH system and derive two finite-time blow-up results.

  14. Geochronological correlation of the late Precambrian sequences on and around the stable zones of Equatorial Africa

    International Nuclear Information System (INIS)

    Cahen, L.

    1982-01-01

    Very few radiometric age determinations have a bearing on the late Precambrian sequences of the stable zones of Equatorial Africa. A geochronological correlation of these sequences must therefore rest upon a compilation of ages from these stable zones and the corresponding mobile zones. About 15 ages of varying precision more or less well tied up with the stratigraphical sequences, together with results of the study of stromatolite assemblages allow a provisional correlation to be made. One conclusion of this correlation is that most mixtites surrounding the Congo basin are in a 950 +- 50 Ma age bracket and are presumably to be correlated. (Auth.)

  15. A step forward for understanding the morbidity burden in Guinea: a national descriptive study

    Directory of Open Access Journals (Sweden)

    Hu Guoqing

    2011-06-01

    Full Text Available Abstract Background Little evidence on the burden of disease has been reported about Guinea. This study was conducted to demonstrate the morbidity burden in Guinea and provide basic evidence for setting health priorities. Methods A retrospective descriptive study was designed to present the morbidity burden of Guinea. Morbidity data were extracted from the National Health Statistics Report of Guinea of 2008. The data are collected based on a pyramid of facilities which includes two national hospitals (teaching hospitals, seven regional hospitals, 26 prefectural hospitals, 8 communal medical centers, 390 health centers, and 628 health posts. Morbidity rates were calculated to measure the burden of non-fatal diseases. The contributions of the 10 leading diseases were presented by sex and age group. Results In 2008, a total of 3,936,599 cases occurred. The morbidity rate for males was higher than for females, 461 versus 332 per 1,000 population. Malaria, respiratory infections, diarrheal diseases, helminthiases, and malnutrition ranked in the first 5 places and accounted for 74% of the total burden, respectively having a rate of 148, 64, 33, 32, and 14 per 1,000 population. The elderly aged 65+ had the highest morbidity rate (611 per 1,000 population followed by working-age population (458 per 1,000 population and children (396 per 1,000 population while the working-age population aged 25-64 contributed the largest part (39% to total cases. The sex- and age-specific spectrum of morbidity burden showed a similar profile except for small variations. Conclusion Guinea has its unique morbidity burden. The ten leading causes of morbidity burden, especially for malaria, respiratory infections, diarrheal diseases, helminthiases, and malnutrition, need to be prioritized in Guinea.

  16. Asymmetric Response of the Equatorial Pacific SST to Climate Warming and Cooling

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Fukai [Physical Oceanography Laboratory/Qingdao Collaborative Innovation Center of Marine Science and Technology, Ocean University of China, and Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Luo, Yiyong [Physical Oceanography Laboratory/Qingdao Collaborative Innovation Center of Marine Science and Technology, Ocean University of China, and Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Lu, Jian [Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory, Richland, Washington; Garuba, Oluwayemi [Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory, Richland, Washington; Wan, Xiuquan [Physical Oceanography Laboratory/Qingdao Collaborative Innovation Center of Marine Science and Technology, Ocean University of China, and Qingdao National Laboratory for Marine Science and Technology, Qingdao, China

    2017-09-01

    The response of the equatorial Pacific Ocean to heat fluxes of equal amplitude but opposite sign is investigated using the Community Earth System Model (CESM). Results show a strong asymmetry in SST changes. In the eastern equatorial Pacific (EEP), the warming responding to the positive forcing exceeds the cooling to the negative forcing; while in the western equatorial Pacific (WEP), it is the other way around and the cooling surpasses the warming. This leads to a zonal dipole asymmetric structure, with positive values in the east and negative values in the west. A surface heat budget analysis suggests that the SST asymmetry is mainly resulted from the oceanic horizontal advection and vertical entrainment, with both of their linear and nonlinear components playing a role. For the linear component, its change appears to be more significant over the EEP (WEP) in the positive (negative) forcing scenario, favoring the seesaw pattern of the SST asymmetry. For the nonlinear component, its change acts to warm (cool) the EEP (WEP) in both scenarios, also favorable for the development of the SST asymmetry. Additional experiments with a slab ocean confirm the dominant role of ocean dynamical processes for this SST asymmetry. The net surface heat flux, in contrast, works to reduce the SST asymmetry through its shortwave radiation and latent heat flux components, with the former being related to the nonlinear relationship between SST and convection, and the latter being attributable to Newtonian damping and air-sea stability effects. The suppressing effect of shortwave radiation on SST asymmetry is further verified by partially coupled overriding experiments.

  17. Meteorology of Jupiter's Equatorial Hot Spots and Plumes from Cassini

    Science.gov (United States)

    Choi, David Sanghun; Showman, Adam P.; Vasavada, Ashwin R.; Simon-Miller, Amy A.

    2013-01-01

    We present an updated analysis of Jupiter's equatorial meteorology from Cassini observations. For two months preceding the spacecraft's closest approach, the Imaging Science Subsystem (ISS) onboard regularly imaged the atmosphere. We created time-lapse movies from this period in order to analyze the dynamics of equatorial hot spots and their interactions with adjacent latitudes. Hot spots are relatively cloud-free regions that emit strongly at 5 lm; improved knowledge of these features is crucial for fully understanding Galileo probe measurements taken during its descent through one. Hot spots are quasistable, rectangular dark areas on visible-wavelength images, with defined eastern edges that sharply contrast with surrounding clouds, but diffuse western edges serving as nebulous boundaries with adjacent equatorial plumes. Hot spots exhibit significant variations in size and shape over timescales of days and weeks. Some of these changes correspond with passing vortex systems from adjacent latitudes interacting with hot spots. Strong anticyclonic gyres present to the south and southeast of the dark areas appear to circulate into hot spots. Impressive, bright white plumes occupy spaces in between hot spots. Compact cirrus-like 'scooter' clouds flow rapidly through the plumes before disappearing within the dark areas. These clouds travel at 150-200 m/s, much faster than the 100 m/s hot spot and plume drift speed. This raises the possibility that the scooter clouds may be more illustrative of the actual jet stream speed at these latitudes. Most previously published zonal wind profiles represent the drift speed of the hot spots at their latitude from pattern matching of the entire longitudinal image strip. If a downward branch of an equatorially-trapped Rossby wave controls the overall appearance of hot spots, however, the westward phase velocity of the wave leads to underestimates of the true jet stream speed.

  18. Equatorial noise emissions with quasiperiodic modulation of wave intensity

    Czech Academy of Sciences Publication Activity Database

    Němec, F.; Santolík, Ondřej; Hrbáčková, Zuzana; Pickett, J. S.; Cornilleau-Wehrlin, N.

    2015-01-01

    Roč. 120, č. 4 (2015), s. 2649-2661 ISSN 2169-9380 R&D Projects: GA MŠk(CZ) LH11122 Institutional support: RVO:68378289 Keywords : equatorial noise * magnetosonic waves * quasiperiodic modulation Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.318, year: 2015 http://onlinelibrary.wiley.com/doi/10.1002/2014JA020816/full

  19. Increases of equatorial total electron content (TEC) during magnetic storms

    International Nuclear Information System (INIS)

    Yeboah-Amankwah, D.

    1976-01-01

    This paper is a report on the analysis of equatorial electron content, TEC, during magnetic storms. Storms between 1969 and 1972 have been examined as part of an on-going study of TEC morphology during magnetically disturbed days. The published magnetic Ksup(p) indices and TEC data from the Legon abservatory have been employed. The general picture arising from the analysis is that the total electron content of the ionosphere is significantly enhanced during magnetic storms. (author)

  20. Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs

    Science.gov (United States)

    Clay, Emlyn; Patacchini, Riccardo; Trevisani, Marcello; Preti, Delia; Branà, Maria Pia; Spina, Domenico

    2016-01-01

    Cough remains a major unmet clinical need, and preclinical animal models are not predictive for new antitussive agents. We have investigated the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses in rabbits and guinea pigs. Ozone induced a significant increase in cough frequency and a decrease in time to first cough to inhaled citric acid in both conscious guinea pigs and rabbits. This response was inhibited by the established antitussive drugs codeine and levodropropizine. In contrast to the guinea pig, hypertussive responses in the rabbit were not inhibited by bronchodilator drugs (β2 agonists or muscarinic receptor antagonists), suggesting that the observed hypertussive state was not secondary to bronchoconstriction in this species. The ozone-induced hypertussive response in the rabbit was inhibited by chronic pretreatment with capsaicin, suggestive of a sensitization of airway sensory nerve fibers. However, we could find no evidence for a role of TRPA1 in this response, suggesting that ozone was not sensitizing airway sensory nerves via activation of this receptor. Whereas the ozone-induced hypertussive response was accompanied by a significant influx of neutrophils into the airway, the hypertussive response was not inhibited by the anti-inflammatory phosphodiesterase 4 inhibitor roflumilast at a dose that clearly exhibited anti-inflammatory activity. In summary, our results suggest that ozone-induced hypertussive responses to citric acid may provide a useful model for the investigation of novel drugs for the treatment of cough, but some important differences were noted between the two species with respect to sensitivity to bronchodilator drugs. PMID:26837703

  1. Replication and Transmission of the Novel Bovine Influenza D Virus in a Guinea Pig Model.

    Science.gov (United States)

    Sreenivasan, Chithra; Thomas, Milton; Sheng, Zizhang; Hause, Ben M; Collin, Emily A; Knudsen, David E B; Pillatzki, Angela; Nelson, Eric; Wang, Dan; Kaushik, Radhey S; Li, Feng

    2015-12-01

    Influenza D virus (FLUDV) is a novel influenza virus that infects cattle and swine. The goal of this study was to investigate the replication and transmission of bovine FLUDV in guinea pigs. Following direct intranasal inoculation of animals, the virus was detected in nasal washes of infected animals during the first 7 days postinfection. High viral titers were obtained from nasal turbinates and lung tissues of directly inoculated animals. Further, bovine FLUDV was able to transmit from the infected guinea pigs to sentinel animals by means of contact and not by aerosol dissemination under the experimental conditions tested in this study. Despite exhibiting no clinical signs, infected guinea pigs developed seroconversion and the viral antigen was detected in lungs of animals by immunohistochemistry. The observation that bovine FLUDV replicated in the respiratory tract of guinea pigs was similar to observations described previously in studies of gnotobiotic calves and pigs experimentally infected with bovine FLUDV but different from those described previously in experimental infections in ferrets and swine with a swine FLUDV, which supported virus replication only in the upper respiratory tract and not in the lower respiratory tract, including lung. Our study established that guinea pigs could be used as an animal model for studying this newly emerging influenza virus. Influenza D virus (FLUDV) is a novel emerging pathogen with bovine as its primary host. The epidemiology and pathogenicity of the virus are not yet known. FLUDV also spreads to swine, and the presence of FLUDV-specific antibodies in humans could indicate that there is a potential for zoonosis. Our results showed that bovine FLUDV replicated in the nasal turbinate and lungs of guinea pigs at high titers and was also able to transmit from an infected animal to sentinel animals by contact. The fact that bovine FLUDV replicated productively in both the upper and lower respiratory tracts of guinea pigs

  2. Evidence of late Palaeocene-early Eocene equatorial rain forest refugia in southern Western Ghats, India.

    Science.gov (United States)

    Prasad, V; Farooqui, A; Tripathi, S K M; Garg, R; Thakur, B

    2009-11-01

    Equatorial rain forests that maintain a balance between speciation and extinction are hot-spots for studies of biodiversity. Western Ghats in southern India have gained attention due to high tropical biodiversity and endemism in their southern most area. We attempted to track the affinities of the pollen fl ora of the endemic plants of Western Ghat area within the fossil palynoflora of late Palaeocene-early Eocene (approximately 55-50 Ma) sedimentary deposits of western and northeastern Indian region. The study shows striking similarity of extant pollen with twenty eight most common fossil pollen taxa of the early Palaeogene. Widespread occurrences of coal and lignite deposits during early Palaeogene provide evidence of existence of well diversified rain forest community and swampy vegetation in the coastal low lying areas all along the western and northeastern margins of the Indian subcontinent. Prevalence of excessive humid climate during this period has been seen as a result of equatorial positioning of Indian subcontinent, superimposed by a long term global warming phase (PETM and EECO) during the early Palaeogene. The study presents clear evidence that highly diversifi ed equatorial rain forest vegetation once widespread in the Indian subcontinent during early Palaeogene times, are now restricted in a small area as a refugia in the southernmost part of the Western Ghat area. High precipitation and shorter periods of dry months seem to have provided suitable environment to sustain lineages of ancient tropical vegetation in this area of Western Ghats in spite of dramatic climatic changes subsequent to the post India-Asia collision and during the Quaternary and Recent times.

  3. Japan contribution to studies of low-latitude and equatorial ionosphere over Southeast Asia

    Science.gov (United States)

    Yamamoto, M.; Ishii, M.; Otsuka, Y.; Shiokawa, K.; Saito, A.; Tsuda, T.; Fukao, S.

    2008-12-01

    A dense observation network to study ionosphere is deployed over Southeast Asian countries of Indonesia, Thailand, and Vietnam. The Equatorial Atmosphere Radar (EAR) at Kototabang, Indonesia is the center facility, and supporting instruments, i.e., an ionosonde, a VHF ionosphere radar, an optical imager, a GPS scintillation receiver, a magnetometer, a meteor radar, etc. are collocated. NICT operates the ionosonde network SEALION (South East Asian Low-latitude IOnosonde Network) that meridionally extends from the EAR site to Chumphong and Chiang Mai in Thailand, and two more sites (Baq Liu and Phy Thuy) in Vietnam. Additional facilities are an MF radar at Pameungpeuk, Indonesia, and an optical imager at Darwin, Australia. We have been observing plasma bubbles since 2001, that, for example, contributed clarification of time- spatial structures of the phenomena, their relationship to the pre-reversal enhancement, control of bubble occurrence by the meridional winds, etc. We are starting studies of their seeding by means of atmospheric waves that propages from the lower atmosphere, too. In 2008, Nagoya University will soon install three Fabry-Perot interferometers at the EAR site, Chiang Mai, and Darwin. We also have a plan to install digital beacon receivers in some of these sites. Next research program that follows CPEA (Coupling Processes in the Equatorial Atmosphere, 2001-2007) is under planning now. Our main facilities cover ± 10° of geomagnetic latitude, where the magnetic declination is relatively small, and the geomagnetic equator is in the geographic northern hemisphere. We will review our achievements, and show on-going efforts and future plans. Collaboration with the C/NOFS satellite, and comparisons to results from the American sector should be beneficial for global-scale understanding of the equatorial ionosphere/atmosphere.

  4. OH Airglow and Equatorial Variations Observed by ISUAL Instrument on Board the FORMOSAT 2 Satellite

    Directory of Open Access Journals (Sweden)

    Jan-Bai Nee

    2010-01-01

    Full Text Available OH airglow observed by the ISUAL (Imager of Sprites and Upper Atmospheric Lightning instrument on board the FORMOSAT 2 satellite is reported in this paper. The satellite is sun-synchronous and it returns to the same orbit at the same local time daily. By using this property, we can study the upper atmosphere in detail. With a CCD camera, ISUAL has measured the emission layers of OH Meinel band at 630 nm for several two-week periods in 2004 and 2007 in equatorial regions. ISUAL images are snapshots of the atmosphere 250 km (height ¡_ 1200 km (horizontal distance. These images of OH airglow are analyzed to derive its peak height and latitudinal variations. ISUAL observation is unique in its capability of continuous observation of the upper atmosphere as the satellite travels from south to north along a specific orbit. However, 630 nm filter also measured O(1D at 200 km, and there are interferences between O(1D and OH airglows as as observed from a distance in space. We have studied the overlap of two airglows by simulations, and our final analyses show that OH airglow can be correctly derived with its average peak height of 89 ¡_ 2.1 km usually lying within ¡_10¢X latitude about the equator. ISUAL data reveal detailed structures of equatorial OH airglow such as the existences of a few secondary maxima within the equatorial regions, and the oscillations of the peak latitudes. These results are discussed and compared with previous reports.

  5. A near-infrared, optical, and ultraviolet polarimetric and timing investigation of complex equatorial dusty structures

    Science.gov (United States)

    Marin, F.; Rojas Lobos, P. A.; Hameury, J. M.; Goosmann, R. W.

    2018-05-01

    Context. From stars to active galactic nuclei, many astrophysical systems are surrounded by an equatorial distribution of dusty material that is, in a number of cases, spatially unresolved even with cutting edge facilities. Aims: In this paper, we investigate if and how one can determine the unresolved and heterogeneous morphology of dust distribution around a central bright source using time-resolved polarimetric observations. Methods: We used polarized radiative transfer simulations to study a sample of circumnuclear dusty morphologies. We explored a grid of geometrically variable models that are uniform, fragmented, and density stratified in the near-infrared, optical, and ultraviolet bands, and we present their distinctive time-dependent polarimetric signatures. Results: As expected, varying the structure of the obscuring equatorial disk has a deep impact on the inclination-dependent flux, polarization degree and angle, and time lags we observe. We find that stratified media are distinguishable by time-resolved polarimetric observations, and that the expected polarization is much higher in the infrared band than in the ultraviolet. However, because of the physical scales imposed by dust sublimation, the average time lags of months to years between the total and polarized fluxes are important; these time lags lengthens the observational campaigns necessary to break more sophisticated, and therefore also more degenerated, models. In the ultraviolet band, time lags are slightly shorter than in the infrared or optical bands, and, coupled to lower diluting starlight fluxes, time-resolved polarimetry in the UV appears more promising for future campaigns. Conclusions: Equatorial dusty disks differ in terms of inclination-dependent photometric, polarimetric, and timing observables, but only the coupling of these different markers can lead to inclination-independent constraints on the unresolved structures. Even though it is complex and time consuming, polarized

  6. Guest investigator program study: Physics of equatorial plasma bubbles

    Science.gov (United States)

    Tsunoda, Roland T.

    1994-01-01

    Plasma bubbles are large-scale (10 to 100 km) depletions in plasma density found in the night-time equatorial ionosphere. Their formation has been found to entail the upward transport of plasma over hundreds of kilometers in altitude, suggesting that bubbles play significant roles in the physics of many of the diverse and unique features found in the low-latitude ionosphere. In the simplest scenario, plasma bubbles appear first as perturbations in the bottomside F layer, which is linearly unstable to the gravitationally driven Rayleigh-Taylor instability. Once initiated, bubbles develop upward through the peak of the F layer into its topside (sometimes to altitudes in excess of 1000 km), a behavior predicted by the nonlinear form of the same instability. While good general agreement has been found between theory and observations, little is known about the detailed physics associated with plasma bubbles. Our research activity centered around two topics: the shape of plasma bubbles and associated electric fields, and the day-to-day variability in the occurrence of plasma bubbles. The first topic was pursued because of a divergence in view regarding the nonlinear physics associated with plasma bubble development. While the development of perturbations in isodensity contours in the bottomside F layer into plasma bubbles is well accepted, some believed bubbles to be cylinder-like closed regions of depleted plasma density that floated upward leaving a turbulent wake behind them (e.g., Woodman and LaHoz, 1976; Ott, 1978; Kelley and Ott, 1978). Our results, summarized in a paper submitted to the Journal of Geophysical Research, consisted of incoherent scatter radar measurements that showed unambiguously that the depleted region is wedgelike and not cylinderlike, and a case study and modeling of SM-D electric field instrument (EFI) measurements that showed that the absence of electric-field perturbations outside the plasma-depleted region is a distinct signature of wedge

  7. Microbial flora of odontogenic abscesses in pet guinea pigs.

    Science.gov (United States)

    Minarikova, A; Hauptman, K; Knotek, Z; Jekl, V

    2016-10-01

    Abscesses of odontogenic origin in guinea pigs pose a serious health problem and need to be treated with a combination of surgical and medical therapy. The aim of this prospective study was to describe the microbial flora of odontogenic abscesses associated with osteomyelitis in 24 pet guinea pigs, to perform antibiotic sensitivity testing, and to make recommendations for practitioners on the antibiotics of first choice. Inclusion criteria for the study included the animal being diagnosed with an odontogenic abscess which underwent surgery and was not pre-treated with an antibiotic. Inclusion criteria matched for 24 guinea pigs. Samples (pus, capsule and affected tooth/bone) for bacteriological examination were collected under sterile conditions during the surgical procedure. The most commonly isolated bacteria from abscesses of odontogenic origin were Bacteroides fragilis in 12.8 per cent (6/47) of cases, Pasteurella multocida in 10.6 per cent (5/47) and Peptostreptococcus anaerobius in 8.5 per cent (4/47). Aerobic bacterial species only were isolated in 29.2 per cent (7/24) of cases, anaerobic bacteria only were isolated in 33.3 per cent (8/24), and mixed infection with anaerobic and aerobic bacterial species was seen in 37.5 per cent (9/24). Aerobes (n=20) were sensitive to enrofloxacin and marbofloxacin in 100 per cent of samples, benzylpenicillin potassium (penicillin G, PNCG) in 90 per cent, cephalotin in 85 per cent, amoxicillin-clavulanate in 75 per cent, doxycycline in 70 per cent, gentamicin in 65 per cent and trimethoprim-sulfamethoxazole in 55 per cent. Anaerobes (n=27) were sensitive to amoxicillin-clavulanate in 100 per cent of cases, clindamycin in 96.3 per cent, metronidazole in 92.6 per cent, PNCG in 92.6 per cent and cephalotin in 74.1 per cent. As guinea pigs are strictly herbivorous animals, based on the results of this study the recommended antibiotic treatment for odontogenic abscesses is a combination of fluoroquinolones and metronidazole

  8. Gravitational self-force correction to the innermost stable circular equatorial orbit of a Kerr black hole.

    Science.gov (United States)

    Isoyama, Soichiro; Barack, Leor; Dolan, Sam R; Le Tiec, Alexandre; Nakano, Hiroyuki; Shah, Abhay G; Tanaka, Takahiro; Warburton, Niels

    2014-10-17

    For a self-gravitating particle of mass μ in orbit around a Kerr black hole of mass M ≫ μ, we compute the O(μ/M) shift in the frequency of the innermost stable circular equatorial orbit due to the conservative piece of the gravitational self-force acting on the particle. Our treatment is based on a Hamiltonian formulation of the dynamics in terms of geodesic motion in a certain locally defined effective smooth spacetime. We recover the same result using the so-called first law of binary black-hole mechanics. We give numerical results for the innermost stable circular equatorial orbit frequency shift as a function of the black hole's spin amplitude, and compare with predictions based on the post-Newtonian approximation and the effective one-body model. Our results provide an accurate strong-field benchmark for spin effects in the general-relativistic two-body problem.

  9. The invasion of Piper aduncum in Papua New Guinea: friend or foe?

    NARCIS (Netherlands)

    Hartemink, A.E.

    2002-01-01

    About 75% of the land mass of Papua New Guinea is covered by primary forest which is assumed to have a high biodiversity. Overall there has been little decrease in the area under primary forest although some has resulted from logging activities and expansion of plantation agriculture. Shifting

  10. Secondary Infections with Ebola Virus in Rural Communities, Liberia and Guinea, 2014–2015

    Science.gov (United States)

    Nyenswah, Tolbert; Keita, Sakoba; Diallo, Boubakar; Kateh, Francis; Amoah, Aurora; Nagbe, Thomas K.; Raghunathan, Pratima; Neatherlin, John C.; Kinzer, Mike; Pillai, Satish K.; Attfield, Kathleen R.; Hajjeh, Rana; Dweh, Emmanuel; Painter, John; Barradas, Danielle T.; Williams, Seymour G.; Blackley, David J.; Kirking, Hannah L.; Patel, Monita R.; Dea, Monica; Massoudi, Mehran S.; Barskey, Albert E.; Zarecki, Shauna L. Mettee; Fomba, Moses; Grube, Steven; Belcher, Lisa; Broyles, Laura N.; Maxwell, T. Nikki; Hagan, Jose E.; Yeoman, Kristin; Westercamp, Matthew; Mott, Joshua; Mahoney, Frank; Slutsker, Laurence; DeCock, Kevin M.; Marston, Barbara; Dahl, Benjamin

    2016-01-01

    Persons who died of Ebola virus disease at home in rural communities in Liberia and Guinea resulted in more secondary infections than persons admitted to Ebola treatment units. Intensified monitoring of contacts of persons who died of this disease in the community is an evidence-based approach to reduce virus transmission in rural communities. PMID:27268508

  11. Secondary Infections with Ebola Virus in Rural Communities, Liberia and Guinea, 2014-2015.

    Science.gov (United States)

    Lindblade, Kim A; Nyenswah, Tolbert; Keita, Sakoba; Diallo, Boubakar; Kateh, Francis; Amoah, Aurora; Nagbe, Thomas K; Raghunathan, Pratima; Neatherlin, John C; Kinzer, Mike; Pillai, Satish K; Attfield, Kathleen R; Hajjeh, Rana; Dweh, Emmanuel; Painter, John; Barradas, Danielle T; Williams, Seymour G; Blackley, David J; Kirking, Hannah L; Patel, Monita R; Dea, Monica; Massoudi, Mehran S; Barskey, Albert E; Zarecki, Shauna L Mettee; Fomba, Moses; Grube, Steven; Belcher, Lisa; Broyles, Laura N; Maxwell, T Nikki; Hagan, Jose E; Yeoman, Kristin; Westercamp, Matthew; Mott, Joshua; Mahoney, Frank; Slutsker, Laurence; DeCock, Kevin M; Marston, Barbara; Dahl, Benjamin

    2016-09-01

    Persons who died of Ebola virus disease at home in rural communities in Liberia and Guinea resulted in more secondary infections than persons admitted to Ebola treatment units. Intensified monitoring of contacts of persons who died of this disease in the community is an evidence-based approach to reduce virus transmission in rural communities.

  12. Evaluating the Professional Learning for "Cultural Mathematics" in Papua New Guinea's Elementary Schools

    Science.gov (United States)

    Bino, Vagi; Sakopa, Priscilla; Tau, Kila; Kull, Martha

    2014-01-01

    Qualitative and quantitative data are both being used to evaluate a large project in remote areas of Papua New Guinea. Results from teacher and student questionnaires are yet to be evaluated. The responses from teachers participating in the project workshops are reported here to be extremely positive towards the content and delivery of the…

  13. The influence of starvation upon hepatic drug metabolism in rats, mice, and guinea pigs.

    Science.gov (United States)

    Furner, R. L.; Feller, D. D.

    1971-01-01

    Male rats, mice, and guinea pigs were starved for 1, 2, or 3 days, and the metabolism of ethylmorphine, p-nitroanisole, and aniline was studied. Results suggest that the oxidative enzyme systems studied are not interdependent, and the pathways studied appear to be species dependent.

  14. Positive Streptobacillus moniliformis PCR in guinea pigs likely due to Leptotrichia spp.

    Science.gov (United States)

    Boot, Ron; Van de Berg, Lia; Reubsaet, Frans A G; Vlemminx, Maurice J

    2008-04-30

    Streptobacillus moniliformis is a zoonotic bacterium. We obtained positive S. moniliformis PCR results in oral swab samples from guinea pigs from an experimental colony and the breeding colony of origin. Comparison of the DNA sequence of an amplicon with deposited 16S rDNA sequences revealed that Leptotrichia sp. can be the source of a false positive S. moniliformis PCR outcome.

  15. The value and limitations of rechallenge in the guinea pig maximization test

    DEFF Research Database (Denmark)

    Frankild, S; Basketter, D A; Andersen, Klaus Ejner

    1996-01-01

    The guinea pig maximization test (GPMT) has played a primary rôle in the evaluation of potential skin contact sensitizers for 25 years. In the OECD Guideline 406 from 1993, it is specifically suggested that equivocal results from the initial challenge in the GPMT should be evaluated further...

  16. Frequency response for electromotility of isolated outer hair cells of the guinea pig

    NARCIS (Netherlands)

    Wit, HP; vanDijk, P; Segenhout, HM

    1996-01-01

    Frequency and impulse responses were determined for isolated guinea pig outer hair cells by electrically stimulating the cells between two wire electrodes with white noise. Cells were attached to the bottom of a small culture dish at one end while the other end was freely moving. Results have the

  17. Equatorial modes observed in atmospheric variables

    Indian Academy of Sciences (India)

    Weather Forecasting) ERA-40 reanalysis (Uppala et al 2005). NCEP does not give divergence as a product (it can be computed), whereas diver- gence is one of .... study is robust and gives results consistent with those based on FFT. This has provided the confi- dence that the FFT-wavelet method can be used to study the ...

  18. The response of the equatorial Pacific Ocean to a westerly wind burst in May 1986

    Science.gov (United States)

    McPhaden, Michael J.; Freitag, H. Paul; Hayes, Stanley P.; Taft, Bruce A.; Chen, Zeshi; Wyrtki, Klaus

    1988-09-01

    Western Pacific westerly wind bursts of 1- to 3-week duration are potentially important in triggering and sustaining El Niño-Southern Oscillation events. One such burst of 10-day duration and maximum speeds of greater than 10 m s-1 occurred in May 1986 west of the date line. The response to this westerly wind burst is documented from equatorial current meter moorings, thermistor chain moorings, and sea level and hydrographic data. At 0°, 165°E in the western Pacific the thermocline was depressed by 25 m, sea surface temperature dropped by 0.3°-0.4°C, and sea level rose by 10-15 cm a few days after the maximum in westerly wind speed. Likewise, the South Equatorial Current rapidly accelerated eastward and attained speeds in excess of 100 cm s-1. Vertical shear in an approximately 100 m deep surface layer reversed within a few days of the winds, consistent with a simple model of equatorial mixed layer dynamics in which vertical eddy viscosities are inferred to be O(100 cm2 s-1). A sharp Kelvin wavelike pulse in sea level propagated out of the directly forced region into the central and eastern Pacific. The pulse took 45 days to travel from Tarawa (1°N, 173°E) to La Libertad (2°S, 81°W) on the South American coast, at an average phase speed of about 300 cm s-1. This is of the same order of magnitude as, but significantly higher than, the phase speed of a first baroclinic mode Kelvin wave and is probably the result of Doppler shifting by the Equatorial Undercurrent. A rise in sea surface temperature of about 1°C in 2 days occurred at 0°N, 110°W with the passage of the pulse. However, coincidental meridional advection of a sharp sea surface temperature front, rather than zonal advection of downwelling associated with the pulse, appears to be responsible for this warming. The relevance of this wind-forced pulse to the subsequent evolution of the 1986-1987 El Niño-Southern Oscillation event is discussed in the light of these observations.

  19. Sub-kilometer Simulation of Equatorial Plasma Bubble and Comparison with Satellite Observations

    Science.gov (United States)

    Yokoyama, T.; Pfaff, R. F., Jr.; Stolle, C.; Su, S. Y.

    2016-12-01

    Equatorial plasma bubble (EPB) is a well-known phenomenon in the equatorial ionospheric F region. As it causes severe scintillation in the amplitude and phase of radio signals, it is important to understand and forecast the occurrence of EPB from a space weather point of view. The development of EPB is presently believed as an evolution of the generalized Rayleigh-Taylor instability. We have already developed a 3D high-resolution bubble (HIRB) model with a grid spacing of as small as 1 km and presented nonlinear growth of EPB which shows very turbulent internal structures such as bifurcation and pinching. Recent upgrade of the HIRB model has made it possible to conduct the simulation with sub-kilometer grid spacing. The simulation results can be compared with various in situ satellite observations such as plasma drift velocity, plasma density, magnetic field, and their structures and power spectra, e.g. from the C/NOFS, ROCSAT, CHAMP, or Swarm missions. Our initial results show encouraging agreement between model results and observational data.

  20. Reflection of equatorial Kelvin waves at eastern ocean boundaries Part II: Pacific and Atlantic Oceans

    Directory of Open Access Journals (Sweden)

    J. Soares

    1999-06-01

    Full Text Available The effect of viscosity, non linearities, incident wave period and realistic eastern coastline geometry on energy fluxes are investigated using a shallow water model with a spatial resolution of 1/4 degree in both meridional and zonal directions. Equatorial and mid-latitude responses are considered. It is found that (1 the influence of the coastline geometry and the incident wave period is more important for the westward energy flux than for the poleward flux, and (2 the effect of the inclination of the eastern ocean boundary on the poleward energy flux, for the Pacific and Atlantic Oceans, decline as the period of the incident wave increases. Furthermore, the model simulations suggest that the poleward energy fluxes from meridional boundaries give plausible results for motions of seasonal and annual periods. For comparatively shorter periods, a realistic coastline geometry has to be included for more accurate results. It is recommended that any numerical model involving the reflection of baroclinic Rossby waves (of intraseasonal, seasonal or annual periods on the eastern Pacific or Atlantic Oceans, should consider the effect of the coastline geometry in order to improve the accuracy of the results.Key words. Oceanography: general (climate and interannual variability; equatorial oceanography. Oceanography: physical (eastern boundary currents.

  1. A diagnostic model for equatorial spread F. 2. The effect of magnetic activity

    International Nuclear Information System (INIS)

    Kelley, M.C.; Maruyama, Takashi

    1992-01-01

    By using a numerical model the authors have studied electric field effects on the generation of equatorial spread F (ESF) in the postmidnight hours. Equatorial electric fields are zonally westward during late evening and postmidnight hours on normal days, while they sometimes reverse to eastward in magnetically disturbed days. The quiet time westward configuration and typical low altitude of the layer results in stable bottomside gradient or at most one with a very low generalized Rayleigh-Taylor growth rate. The model calculation shows that the growth rate becomes significant when the electric field reverses to eastward and may remain so even when the electric field disturbance weakens due to the upward altitude excursion of the layer. These results account for the correlation of ESF occurrence penetration of magnetospheric electric fields during such magnetic activity. The results also show the crucial role of layer height in the physics. They have calculated the growth rates for specific nights in which perturbation of electric fields and plumes were observed at Jicamarca. These case studies suggest that a quantitative requirement for the generation of plumes is that about 10 e-folding times of the linear instability growth occur. They also suggest that a statistical study using ionosonde data could be very valuable in a testing whether a local version of this quantitative measure of event intensity could be useful in predicting plume activity

  2. Radiolabelled soman binding to sera from Rats, Guinea Pigs and Monkeys.

    Science.gov (United States)

    Lenz, David E; Cerasoli, Douglas; Maxwell, Donald M

    2018-02-01

    Soman is a highly toxic organophosphorus chemical warfare compound that binds rapidly and irreversibility to a variety of serine active enzymes, i.e., butyryl- and acetyl-cholinesterases and carboxylesterase. The in vivo toxicity of soman has been reported to vary significantly in different animal species, such as rats and guinea pigs or non-human primates. This species variation makes it difficult to identify appropriate animal models for therapeutic drug development under the US Food and Drug Administration (FDA) Animal Rule. Since species variation in soman toxicity has been correlated with species variation in serum carboxylesterase, we undertook to determine if serum from guinea pigs, rats and non-human primates bound different levels of soman in vitro in the presence of equimolar concentrations of soman. Our results demonstrated that the amount of soman bound in the serum of rats was 4 uM, but essentially null in guinea pigs or non-human primates. The results strongly correlate with the presence or absence of carboxylesterase in the serum of animals and the difference in the toxic dose of soman in various species. Our results support prior suggestions that guinea pigs and non-human primates may be better animal models for the development of antidotes under the FDA Animal Rule. Published by Elsevier B.V.

  3. Streptomycin action to the mammalian inner ear vestibular organs: comparison between pigmented guinea pigs and rats.

    Science.gov (United States)

    Meza, Graciela; Aguilar-Maldonado, Beatriz

    2007-01-01

    Streptomycin is the antibiotic of choice to treat tuberculosis and other infectious diseases but it causes vestibular malfunction and hipoacusia. Rodents are usually employed as models of drug action to the inner ear and results are extrapolated to what happens in humans. In rats, streptomycin destroys macular sensory cells and does not affect cochlear ones, whereas in guinea pigs the contrary is true. Action on the vestibular cristae cells involved in vestibulo-ocular reflex integrity is less clear. Thus, we compared this response in both pigmented guinea pigs (Cavia cobaya) and rats (Rattus norvegicus) after parallel streptomycin chronic treatment. In guinea pigs, the reflex was obliterated along treatment time; in rats this behavior was not observed, suggesting that the end organ target was diverse. In recent studies, streptidine, a streptomycin derivative found in the blood of humans and rats treated with streptomycin, was the actual ototoxic agent. The putative streptomycin vestibular organ target observed in humans corresponds with the guinea pig observations. Results observed in rats are controversial: streptidine did not cause any damage either to vestibular cristae nor auditory cells. We hypothesize differential drug metabolism and distribution and conclude that results in laboratory animals may not always be applicable in the human situation.

  4. Geochemistry of coral from Papua New Guinea as a proxy for ENSO ocean-atmosphere interactions in the Pacific Warm Pool

    Science.gov (United States)

    Ayliffe, Linda K.; Bird, Michael I.; Gagan, Michael K.; Isdale, Peter J.; Scott-Gagan, Heather; Parker, Bruce; Griffin, David; Nongkas, Michael; McCulloch, Malcolm T.

    2004-12-01

    A Porites sp. coral growing offshore from the Sepik and Ramu Rivers in equatorial northern Papua New Guinea has yielded an accurate 20-year history (1977-1996) of sea surface temperature (SST), river discharge, and wind-induced mixing of the upper water column. Depressions in average SSTs of about 0.5-1.0 °C (indicated by coral Sr/Ca) and markedly diminished freshwater runoff to the coastal ocean (indicated by coral δ18O, δ13C and UV fluorescence) are evident during the El Niño - Southern Oscillation (ENSO) events of 1982-1983, 1987 and 1991-1993. The perturbations recorded by the coral are in good agreement with changes in instrumental SST and river discharge/precipitation records, which are known to be diagnostic of the response of the Pacific Warm Pool ocean-atmosphere system to El Niño. Consideration of coastal ocean dynamics indicates that the establishment of northwest monsoon winds promotes mixing of near-surface waters to greater depths in the first quarter of most years, making the coral record sensitive to changes in the Asian-Australian monsoon cycle. Sudden cooling of SSTs by ˜1°C following westerly wind episodes, as indicated by the coral Sr/Ca, is consistent with greater mixing in the upper water column at these times. Furthermore, the coral UV fluorescence and oxygen isotope data indicate minimal contribution of river runoff to surface ocean waters at the beginning of most years, during the time of maximum discharge. This abrupt shift in flood-plume behaviour appears to reflect the duration and magnitude of northwest monsoon winds, which tend to disperse flood plume waters to a greater extent in the water column when wind-mixing is enhanced. Our results suggest that a multi-proxy geochemical approach to the production of long coral records should provide comprehensive reconstructions of tropical paleoclimate processes operating on interannual timescales.

  5. Heterogeneity of Opioid Binding Sites in Guinea Pig Spinal Cord

    Science.gov (United States)

    1984-11-30

    MEDICAL CENTER WILFORD HALL AIR FORCE MEDICAL CENTER Title of Thesis: "Heterogeneity of Opioid Binding Sites in Guinea Pig Spinal Cord" Name of...that the use of any copyrighted material in the dissertation manuscript entitled: "Heterogeneity of Opioid Binding Sites in Guinea Pig Spinal Cord...University of the Health Sciences 11 Abstract Title of Thesis: Heterogenity of Opioid Binding Sites In Guinea Pig Spinal Cord Gary Dean Zarr MAJ/ANC

  6. Vertical and longitudinal electron density structures of equatorial E- and F-regions

    Directory of Open Access Journals (Sweden)

    P. S. Brahmanandam

    2011-01-01

    Full Text Available From global soundings of ionospheric electron density made with FORMOSAT 3/COSMIC satellites for September 2006–August 2009, day-night variations in vertical and longitudinal structures of the electron densities in equatorial E- and F-regions for different seasons are investigated for the first time. The results reveal that the wavenumber-3 and wavenumber-4 patterns dominated the nighttime (22:00–04:00 LT F-region longitudinal structures in solstice and in equinox seasons, respectively. In daytime (08:00–18:00 LT F-region, the wavenumber-4 patterns governed the longitudinal structures in the September equinox and December solstice, and wavenumber-3 in March equinox and June solstice respectively. A comparison of the daytime and nighttime longitudinal electron density structures indicates that they are approximately 180° out of phase with each other. It is believed that this out of phase relation is very likely the result of the opposite phase relation between daytime and nighttime nonmigrating diurnal tidal winds that modulate background E-region dynamo electric field at different places, leading to the day-night change in the locations of the equatorial plasma fountains that are responsible for the formation of the F-region longitudinal structures. Further, a good consistency between the locations of the density structures in the same seasons of the different years for both daytime and nighttime epochs has been noticed indicating that the source mechanism for these structures could be the same.

  7. The intermediate layers and associated tidal motions observed by a digisonde in the equatorial anomaly region

    Directory of Open Access Journals (Sweden)

    C.-C. Lee

    2003-04-01

    Full Text Available This investigation presents an initial attempt to analyze a full year of daily ionosonde observations relevant to the determination of plasma densities, tidal structures, and ion transports in the equatorial anomaly region of the lower ionosphere. Particular focus is on the intermediate layers, their seasonal and diurnal variations, and cause-effect relationships. The ionogram database was recorded using a digisonde portable sounder (DPS at National Central University (NCU, 24 °58' N, 121°11' E during 1996. Statistical results indicate that the intermediate layers appear primarily during the daytime of the spring/winter months. The monthly median height characteristics reveal that the layers descend from high to low altitudes and different tidal motions control the layers in different months. Generally, the semi-diurnal and quarter-diurnal tides, which cause ionization convergence, are mainly in the spring/winter and summer/autumn months, respectively. Variations in the electron densities of the layers also indicate that the density increases could result from a great number of molecular and metallic ions. Furthermore, a novel approach to ionogram presentation is introduced to investigate the intermediate layers. This approach allows the DPS to characterize the detailed daily information of the intermediate layers.Key words. Ionosphere (equatorial ionosphere; ionosphere-atmosphere interactions; ionospheric irregularities

  8. Vestido, identidad y folklore. La invención de un vestido nacional de Guinea Ecuatorial

    Directory of Open Access Journals (Sweden)

    Valenciano-Mañé, Alba

    2012-06-01

    Full Text Available Focussing on clothing viewed as a body practice, this paper attempts to provide an ethnographic overview through the examination of the creation of the national dress of Equatorial Guinea. With a discussion of the importance of the personal motivation of its promoters, the reasons for its alleged failure and the recent attempts in current fashion shows in Malabo to (reproduce identity discourses, this paper also seeks to demonstrate the capacity of dress as a tool for social control, resistance and identity (recreation.

    Situando el vestido como práctica corporal en el centro de la reflexión, el artículo efectúa un recorrido etnográfico por el proceso de creación de un vestido nacional de Guinea Ecuatorial. Se presentará la importancia de la ecuación personal de sus impulsores, los motivos de su fracaso y las recientes tentativas de (reproducción de discursos identitarios en los actuales fashion shows de Malabo. De este modo, se pretende demostrar el potencial del vestido como herramienta de control social, resistencia y (recreación identitaria.

  9. Adaptation of H9N2 AIV in guinea pigs enables efficient transmission by direct contact and inefficient transmission by respiratory droplets

    Science.gov (United States)

    Sang, Xiaoyu; Wang, Airong; Ding, Jie; Kong, Huihui; Gao, Xiaolong; Li, Lin; Chai, Tongjie; Li, Yuanguo; Zhang, Kun; Wang, Chengyu; Wan, Zhonghai; Huang, Geng; Wang, Tiecheng; Feng, Na; Zheng, Xuexing; Wang, Hualei; Zhao, Yongkun; Yang, Songtao; Qian, Jun; Hu, Guixue; Gao, Yuwei; Xia, Xianzhu

    2015-01-01

    H9N2 avian influenza viruses circulate worldwide in poultry and have sporadically infected humans, raising concern whether H9N2 viruses have pandemic potential. Here, we use a guinea pig model to examine whether serial passage results in adaptive viral changes that confer a transmissible phenotype to a wild-type H9N2 virus. After nine serial passages of an H9N2 virus through guinea pigs, productive transmission by direct contact occurred in 2/3 guinea pig pairs. The efficiency of transmission by direct contact increased following the fifteenth passage and occurred in 3/3 guinea pig pairs. In contrast, airborne transmission of the passaged virus was less efficient and occurred in 1/6 guinea pig pairs and 0/6 ferret pairs after the fifteenth passage. Three amino acid substitutions, HA1-Q227P, HA2-D46E, and NP-E434K, were sufficient for contact transmission in guinea pigs (2/3 pairs). The two HA amino acid substitutions enhanced receptor binding to α2,3-linked sialic acid receptors. Additionally, the HA2-D46E substitution increased virus thermostability whereas the NP-E434K mutation enhanced viral RNA polymerase activity in vitro. Our findings suggest that adaptive changes that enhance viral receptor binding, thermostability, and replicative capacity in mammalian cells can collectively enhance the transmissibility of H9N2 AIVs by direct contact in the guinea pig model. PMID:26552719

  10. [Effect of down-regulation of IKs repolarization-reserve on ventricular arrhythmogenesis in a guinea pig model of cardiac hypertrophy].

    Science.gov (United States)

    Wang, Hegui; Huang, Ting; Wang, Zheng; Ge, Nannan; Ke, Yongsheng

    2018-04-28

    To observe the changes of rapidly activated delayed rectifier potassium channel (IKr) and slowly activated delayed rectifier potassium channel (IKs) in cardiac hypertrophy and to evaluate the effects of IKr and IKs blocker on the incidence of ventricular arrhythmias in guinea pigs with left ventricular hypertrophy (LVH).
 Methods: Guinea pigs were divided into a sham operation group and a left ventricular hypertrophy (LVH) group. LVH model was prepared. Whole cell patch-clamp technique was used to record IKr and IKs tail currents in a guinea pig model with LVH. The changes of QTc and the incidence rate of ventricular arrhythmias in LVH guinea pigs were observed by using the IKr and IKs blockers.
 Results: Compared with cardiac cells in the control group, the interventricular septal thickness at end systole (IVSs), left ventricular posterior wall thickness at end systole (LVPWs), QTc interval and cell capacitance in guinea pigs with LVH were significantly increased (Pguinea pigs with LVH compared with the control guinea pigs. In contrast, IKs blocker produced modest increase in QTc interval in guinea pigs of control group with no increase in LVH animals. IKs blocker did not induce ventricular arrhythmias incidence in either control or LVH animals.
 Conclusion: The cardiac hypertrophy-induced arrhythmogenesis is due to the down-regulation 
of IKs.

  11. Case Report of a Satin Guinea Pig with Fibrous Osteodystrophy That Resembles Human Pseudohypoparathyroidism

    Directory of Open Access Journals (Sweden)

    Miguel Gallego

    2017-01-01

    Full Text Available A case report of a 2-year-old female satin guinea pig with a history of dental overgrowth and lameness and radiological lesions of fibrous osteodystrophy is presented. The most relevant clinical findings were bone demineralization, high level of parathyroid hormone (PTH, normophosphatemia, normal ionized calcium, and low total thyroxine (tT4 with a normal renal function. Long-term treatment was based on teeth coronal reduction and maintaining a balanced diet. PTH measurement was performed with a kit suitable for rats to test 4 different paired samples of guinea pigs and resulted in similar results for each pair of measurements. Two kits routinely employed in dogs and cats failed in measuring PTH in guinea pig serum samples. The ionized calcium, PTH, and tT4 values, not previously reported in similar cases, were obtained. The determination of tT4 could be useful in the diagnosis of fibrous osteodystrophy in guinea pigs. The observed findings show similarity with human pseudohypoparathyroidism type Ia, a disease caused by an inactivating heterozygous mutation of the stimulatory G protein α subunit from the maternal genome that induces multiple hormone resistance and that courses with a syndrome called Albright hereditary osteodystrophy. Naturally occurring pseudohypoparathyroidism in animals has been reported previously only in a ferret.

  12. Exploring the Pregnant Guinea Pig as a Model for Group B Streptococcus Intrauterine Infection.

    Science.gov (United States)

    Harrell, Maria I; Burnside, Kellie; Whidbey, Christopher; Vornhagen, Jay; Adams Waldorf, Kristina M; Rajagopal, Lakshmi

    2017-09-01

    Infection of the amniotic cavity remains a major cause of preterm birth, stillbirth, fetal injury and early onset, fulminant infections in newborns. Currently, there are no effective therapies to prevent in utero infection and consequent co-morbidities. This is in part due to the lack of feasible and appropriate animal models to understand mechanisms that lead to in utero infections. Use of mouse and rat models do not fully recapitulate human pregnancy, while pregnant nonhuman primate models are limited by ethical considerations, technical constraints, and cost. Given these limitations, the guinea pig is an attractive animal model for studying pregnancy infections, particularly as the placental structure is quite similar to the human placenta. Here, we describe our studies that explored the pregnant guinea pig as a model to study in utero Group B Streptococci (GBS) infections. We observed that intrauterine inoculation of wild type GBS in pregnant guinea pigs resulted in bacterial invasion and dissemination to the placenta, amniotic fluid and fetal organs. Also, hyperhemolytic GBS such as those lacking the hemolysin repressor CovR/S showed increased dissemination into the amniotic fluid and fetal organs such as the fetal lung and brain. These results are similar to those observed in mouse and non-human primate models of in utero infection, and support use of the guinea pig as a model for studying GBS infections in pregnancy.

  13. The Longitudinal Evolution of Equatorial Coronal Holes

    Science.gov (United States)

    Krista, Larisza D.; McIntosh, Scott W.; Leamon, Robert J.

    2018-04-01

    In 2011, three satellites—the Solar-Terrestrial RElations Observatory A & B, and the Solar Dynamics Observatory (SDO)—were in a unique spatial alignment that allowed a 360° view of the Sun. This alignment lasted until 2014, the peak of solar cycle 24. Using extreme ultraviolet images and Hovmöller diagrams, we studied the lifetimes and propagation characteristics of coronal holes (CHs) in longitude over several solar rotations. Our initial results show at least three distinct populations of “low-latitude” or “equatorial” CHs (below 65^\\circ latitude). One population rotates in retrograde direction and coincides with a group of long-lived (over sixty days) CHs in each hemisphere. These are typically located between 30° and 55^\\circ , and display velocities of ∼55 m s‑1 slower than the local differential rotation rate. A second, smaller population of CHs rotate prograde, with velocities between ∼20 and 45 m s‑1. This population is also long-lived, but observed ±10° from the solar equator. A third population of CHs are short-lived (less than two solar rotations), and they appear over a wide range of latitudes (±65°) and exhibit velocities between ‑140 and 80 m s‑1. The CH “butterfly diagram” we developed shows a systematic evolution of the longer-lived holes; however, the sample is too short in time to draw conclusions about possible connections to dynamo-related phenomena. An extension of the present work to the 22 years of the combined SOHO–SDO archives is necessary to understand the contribution of CHs to the decadal-scale evolution of the Sun.

  14. New experiences on the time required for the appearance of fluoric cachexia in the guinea pig following ingestion of various fluorine salts

    Energy Technology Data Exchange (ETDEWEB)

    Cristiani, H; Chausse, P

    1926-01-01

    Experiments were performed to compare the time it took guinea pigs to develop cachexia after being given sodium fluosilicate or sodium fluoride. Results indicate that a dose-response relationship existed following the ingestion of the fluorine salts in relation to the time it took to produce cachexia. In addition, sodium fluosilicate was found to be more toxic than sodium fluoride. In guinea pigs which were given approximately 1/30 to 1/36 of the lethal dose, cachexia was produced from 44 to 70 days later. In guinea pigs given even smaller doses, cachexia did not appear for one to two years.

  15. Ca(2+)-dependent nonspecific permeability of the inner membrane of liver mitochondria in the guinea fowl (Numida meleagris).

    Science.gov (United States)

    Vedernikov, Aleksander A; Dubinin, Mikhail V; Zabiakin, Vladimir A; Samartsev, Victor N

    2015-06-01

    This comparative study presents the results of the induction of Ca(2+)-dependent nonspecific permeability of the inner membrane (pore opening) of rat and guinea fowl liver mitochondria by mechanisms that are both sensitive and insensitive to cyclosporin A (CsA). It was established that energized rat and guinea fowl liver mitochondria incubated with 1 mM of inorganic phosphate (Pi) are capable of swelling upon addition of at least 125 and 875 nmol of CaCl2 per 1 mg protein, respectively. Under these conditions, the Ca(2+) release from the mitochondria of these animals and a drop in Δψ are observed. All of these processes are inhibited by 1 μM of CsA. FCCP, causing organelle de-energization, induces pore opening in rat and guinea fowl liver mitochondria upon addition of 45 и 625 nmol of CaCl2 per 1 mg protein, respectively. These results suggest the existence of a CsA-sensitive mechanism for the induction of Ca(2+)-dependent pores in guinea fowl liver mitochondria, which has been reported in rat liver mitochondria. However, guinea fowl liver mitochondria have a significantly greater resistance to Ca(2+) as a pore inducer compared to rat liver mitochondria. It was found that the addition of α,ω-hexadecanedioic acid (HDA) to rat and guinea fowl liver mitochondria incubated with CsA and loaded with Ca(2+) causes organelle swelling and Ca(2+) release from the matrix. It is assumed that in contrast to the CsA-sensitive pore, the CsA-insensitive pore induced by HDA in the inner membrane of guinea fowl liver mitochondria, as well as in rat liver mitochondria, is lipid in nature.

  16. results

    Directory of Open Access Journals (Sweden)

    Salabura Piotr

    2017-01-01

    Full Text Available HADES experiment at GSI is the only high precision experiment probing nuclear matter in the beam energy range of a few AGeV. Pion, proton and ion beams are used to study rare dielectron and strangeness probes to diagnose properties of strongly interacting matter in this energy regime. Selected results from p + A and A + A collisions are presented and discussed.

  17. A contrastive analysis of laser heating between the human and guinea pig cochlea by numerical simulations.

    Science.gov (United States)

    Zhang, Kaiyin; Zhang, Yulong; Li, Ji; Wang, Qiuling

    2016-05-23

    The photo-thermal effect has been hypothesised to be one of the most possible biophysical mechanisms for laser-cochlea stimulation. However, there is a lack of studies to date for direct assessing laser heating in humans due to the large body of evidence required to demonstrate safety and efficacy. Instead, the majority focus on animals like the guinea pig, from which a number of valuable results have been gained. However, in light of the increasing need to improve laser safety, it has became necessary to find out whether studies on animals can shed light on safe laser parameters in the human cochlea. Hence, we conducted this contrastive analysis of laser heating between the human and guinea pig cochlea with the aim of assisting further investigations in this field. In this work, a 3D symmetrical model was adopted to simplify the spiraled cochlea. With attention focused on the effect of heat conduction, the time-dependent heat equation was solved using finite element method with the COMSOL Script. In the simulations, cochleae with different sizes and various boundary thermal conditions were utilized. Laser heating in both cochleae has a similar trend. In the first stage, or at the beginning of the laser heating, both cochleae increased their temperatures rapidly. In the second stage in which the laser heating reached a quasi-steady stage, the peak temperatures began to rise slowly as more laser pulses were applied. However, three differences of the laser heating were observed. The first is regarding the temperature rise. The results show that laser heating in guinea pig is higher than that in human under the same laser parameters. The second difference is the fluctuation of temperature rise at the center of the modiolus. There is a larger fluctuation of temperature rise in the guinea pig cochlea, compared with that in the human cochlea. The third one is the time for reaching a steady thermal state. The results show that the guinea pig cochlea takes longer time to

  18. ACTION OF DIPHTHERIA TOXIN IN THE GUINEA PIG

    Science.gov (United States)

    Baseman, Joel B.; Pappenheimer, A. M.; Gill, D. M.; Harper, Annabel A.

    1970-01-01

    The blood clearance and distribution in the tissues of 125I after intravenous injection of small doses (1.5–5 MLD or 0.08–0.25 µg) of 125I-labeled diphtheria toxin has been followed in guinea pigs and rabbits and compared with the fate of equivalent amounts of injected 125I-labeled toxoid and bovine serum albumin. Toxoid disappeared most rapidly from the blood stream and label accumulated and was retained in liver, spleen, and especially in kidney. Both toxin and BSA behaved differently. Label was found widely distributed among all the organs except the nervous system and its rate of disappearance from the tissues paralleled its disappearance from the circulation. There was no evidence for any particular affinity of toxin for muscle tissue or for a "target" organ. Previous reports by others that toxin causes specific and selective impairment of protein synthesis in muscle tissue were not confirmed. On the contrary, both in guinea pigs and rabbits, a reduced rate of protein synthesis was observed in all tissues that had taken up the toxin label. In tissues removed from intoxicated animals of both species there was an associated reduction in aminoacyl transferase 2 content. It is concluded that the primary action of diphtheria toxin in the living animal is to effect the inactivation of aminoacyl transferase 2. The resulting inhibition in rate of protein synthesis leads to morphologic damage in all tissues reached by the toxin and ultimately to death of the animal. PMID:5511567

  19. Bambuterol: uptake and metabolism in guinea pig isolated lungs

    International Nuclear Information System (INIS)

    Ryrfeldt, A.; Nilsson, E.; Tunek, A.; Svensson, L.A.

    1988-01-01

    The lung uptake and biotransformation of 3 H-bambuterol, a prodrug to terbutaline, were studied using isolated perfused and ventilated guinea pig lungs. 14 C-Sucrose was used as an extracellular marker. The lung uptake of bambuterol was significantly (0.05 greater than or equal to P greater than or equal to 0.001) higher than that found for sucrose in single-pass perfusion experiments. High-performance liquid chromatographic (HPLC) analysis showed that 95.6 +/- 3.6% of the effluent 3 H radioactivity was attributable to bambuterol. In recirculating experiments (120 min) the lung biotransformation of 3 H-bambuterol (8.5 pmol/ml) was studied. Both oxidative and hydrolytic metabolism took place. The dominating metabolites were hydroxylated bambuterol and the monocarbamate derivative which is a product of hydrolysis of bambuterol. Traces of terbutaline were also formed. The results show that bambuterol has a certain affinity to lung tissue and that the drug is, to some extent, biotransformed in the guinea pig lung

  20. Spasmolytic effect of traditional herbal formulation on guinea pig ileum

    Directory of Open Access Journals (Sweden)

    Dushyant Kumar

    2015-01-01

    Full Text Available Background: The herbal formulation consisting of Andrographis paniculata Nees., Cassia fistula L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic abdominal pain. Objective: The present study was undertaken to evaluate safety and spasmolytic effect of poly-herbal formulation. Materials and Methods: Acute toxicity studies were carried out in Swiss mice, as per the Organization for Economic Co-operation and Development (OECD guidelines. The spasmolytic activity of the formulation was studied in isolated guinea pig ileum model using histamine and acetylcholine as agonists. The data were analyzed by one-way ANOVA, followed by Dunnetts post-hoc test and P ≤ 0.05 was considered as significant. Results: The formulation did not show any adverse toxic effects and found to be safe. It also showed significant (P < 0.05 relaxation in different agonist like histamine and acetylcholine-induced contractions in guinea pig ileum. Conclusions: Antispasmodic activity of the herbal formulation can be attributed to its atropine-like activity. The present findings, therefore, support its utility in spasmodic abdominal pain.

  1. Placental transfer of ruthenium in rat and guinea-pig

    International Nuclear Information System (INIS)

    Levack, V.M.; Pottinger, H.; Harrison, J.D.

    1994-01-01

    Ruthenium-106 in citrate solution was administered intravenously to rat at different stages of pregnancy and to guinea-pig either before conception or in late pregnancy. The results for rat showed that retention in the embryo/foetus measured at 3-5 days after administration increased from about 0.0002% of injected activity per embryo/foetus on day 12 of gestation to about 0.05% at birth. The relative concentrations of 106 Ru in embryo/foetus and mother (C f /C m ratio) were about 0.1 in each case. Concentrations in the yolk sac on day 12 were about 1% g -1 compared with 0.01% g -1 kin the foetus/ Retention in the guinea-pig foetus in late gestation at 7 days after administration (days 50-57) was about 0.2% injected activity per foetus, corresponding to a C f /C m = 0.2. Retention in each foetoplacental unit was 2% of injected 106 Ru with 50% in the yolk sac, 35% in the placenta and 10% in the foetus. For administration 4 weeks prior to conception, the level of 106 Ru retained in the foetus on day 57 of gestation was two orders of magnitude lower than after short-term administration, with a C f /C m about 0.004. (author)

  2. Effects of radiation on nasal mucosa of guinea pig

    International Nuclear Information System (INIS)

    Xiao Mang; Hu Sunhong; Liu Yuehui

    2004-01-01

    Objective: To study histopathological changes in nasal mucosa of guinea pigs following a series of irradiation. Methods: A total of 60 healthy guinea pigs were divided into two groups randomly: the irradiation group (n=30) and the control group (n=30). The animals of the irradiation group were exposed nasally to linear accelerator X-rays at 5.0 Gy once a week for three weeks. At 1 d, 1 w, 2 w, 4 w, 10 w and half year after X-irradiation five animals per one group were sacrificed randomly, at each time point. Their middle nasal turbinate mucosa was observed under optical microscope and electron microscope, and were analysed by image analysis for histopathological transformation. Results: In the irradiation group, the early histopathological transformation was acute inflammatory reaction, at the fourth week the mucosa began to repair, which ended at the sixth month. But after repaired, some parts of the repaired mucosa were lined with squamous epithelium instead of the normal nasal mucosa. The rate of the cilia-covered area was only 52.9% at the sixth month. Conclusion: The nasal mucosa injury and the squamous metaplasia could form a pathological basis of dysfunction after irradiation

  3. Morphogenesis in guinea grass pastures under rotational grazing strategies

    Directory of Open Access Journals (Sweden)

    Denise Baptaglin Montagner

    2012-04-01

    Full Text Available This study was conducted in order to evaluate the morphogenetic and structural characteristics of guinea grass cv. Mombasa under three post-grazing heights (intense - 30 cm, lenient - 50 cm and variable - 50 in spring-summer and 30 cm in autumn-winter when sward light interception reached 95% during regrowth. Post-grazing heights were allocated to experimental units (0.25 ha in a completely randomized block design with three replications. Post-grazing heights affected only leaf elongation rate and the number of live leaves. Pastures managed with variable post-grazing height showed higher leaf elongation rate in the summer of 2007. This management strategy also resulted in a higher number of live leaves. During the spring of 2006, plants showed lower leaf elongation rate, leaf appearance rate and number of live leaves, and greater phyllochron and leaf lifespan. In contrast, during the summer of 2007, the leaf appearance rate, leaf elongation rate, number of live leaves, and final leaf length were greater while phyllochron, stem elongation rate, and leaf senescence rate were lower. The management of the guinea grass cv. Mombasa with intense or variable post-grazing height throughout the year seems to represent an interesting management target, in terms of leaf appearance rate and number of live leaves.

  4. Huon Terrace IIa1, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  5. Laing Island, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  6. Huon Terrace VIIa3, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  7. Huon Terrace IIa3, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  8. Huon Terrace IIIb, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  9. Huon Terrace VIIa1, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  10. Huon Terrace VII1, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  11. Madang Lagoon, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  12. Huon Terrace V, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  13. Madang Terrace, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  14. Huon Terrace IIa2, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  15. Huon Terrace VII3, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  16. Laing Terrace, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  17. Huon Terrace VIIa2, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  18. Huon Peninsula, Papua New Guinea Fossil and Living Coral Isotope (delta 18O) Data for 130,000 years BP to Present

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Results of analysis of cores collected from 'fossil' massive Porites corals exposed in the raised reefs of the Huon Peninsula, Papua New Guinea (see below for age...

  19. Spontaneous reproductive pathology in female guinea pigs.

    Science.gov (United States)

    Veiga-Parga, Tamara; La Perle, Krista M D; Newman, Shelley J

    2016-11-01

    Reproductive pathology of domestic guinea pigs is underreported to date. To provide a comprehensive review of uterine disease in guinea pigs, we performed a retrospective study of the pathology archives of the University of Tennessee, College of Veterinary Medicine. By histology, 13 of 37 uterine lesions in 23 animals were neoplastic; the other 24 nonneoplastic lesions included cystic endometrial hyperplasia (16 of 24), endometrial hemorrhage (3 of 24), pyometra (2 of 24), polyp (2 of 24), and mucometra (1 of 24). The most common guinea pig uterine neoplasms were uterine leiomyomas (6 of 13), followed by adenomas (3 of 13) and leiomyosarcomas (1 of 13). Other neoplasms included anaplastic tumors of unknown origin (2 of 13) and choriocarcinoma (1 of 13). Both anaplastic tumors and the choriocarcinoma were positive for vimentin. The choriocarcinoma was positive for HSD83B1, indicating a trophoblastic origin and its final diagnosis. All were negative for cytokeratin and smooth muscle. In multiple animals, more than 1 tumor or lesion was reported. Estrogen receptor and progesterone receptor expression was nearly 100% in uterine neoplasms. Nearly all animals for which data were available had cystic rete ovarii (18 of 19); the animal with no cystic rete ovarii had paraovarian cysts. In our study, female pet guinea pigs had a tendency to develop cystic endometrial hyperplasia and uterine neoplasia. Factors for the development of these lesions could be cystic rete ovarii, hormone dysregulation, and/or age. Other factors could contribute to the development of uterine lesions. As in other species, early ovariohysterectomy could decrease the prevalence of uterine lesions. © 2016 The Author(s).

  20. Oil and gas in Papua New Guinea

    International Nuclear Information System (INIS)

    Owen, A.D.; Lattimore, J.C.

    1998-01-01

    This paper documents the current status of oil and gas reserves and production in Papua New Guinea. It then provides an assessment of future prospects for the industry in the context of both the international market for oil and gas and local constraints on the industry's growth. Finally, an estimate of the impact of the industry's development on the economy of PNG is presented. (author)

  1. [Experiences with cage combinations for guinea pigs].

    Science.gov (United States)

    von Zychlinski, J

    1989-01-01

    Special cage units described in 1982 for guinea pigs have been used either as cages for small groups of breeding animals or for caging of growing animals. By using these cages the following advantages have been noted; the cage size can be adapted to number, age and body weight of the animals; aggression and panic are avoided by corners, walls and tunnels; economic use of breeding males by mating with more females.

  2. Elastase-induced emphysema in guinea pigs

    International Nuclear Information System (INIS)

    Loscutoff, S.M.

    1979-01-01

    Pulmonary function changes measured in guinea pigs 4 to 5 wk following intratracheal instillation of crystalline porcine pancreatic elastase resembled comparable changes in humans with moderately severe pulmonary emphysema. Compared with saline-treated controls, elastase-treated animals had increased values for all divisions of lung volume, increased static compliance and prolonged time constants. Since humans with emphysema are especially sensitive to air pollutants, elastase-treated animals may be useful as sensitive animal models in inhalatio toxicology

  3. Longitudinal Variation of the Lunar Tide in the Equatorial Electrojet

    Science.gov (United States)

    Yamazaki, Yosuke; Stolle, Claudia; Matzka, Jürgen; Siddiqui, Tarique A.; Lühr, Hermann; Alken, Patrick

    2017-12-01

    The atmospheric lunar tide is one known source of ionospheric variability. The subject received renewed attention as recent studies found a link between stratospheric sudden warmings and amplified lunar tidal perturbations in the equatorial ionosphere. There is increasing evidence from ground observations that the lunar tidal influence on the ionosphere depends on longitude. We use magnetic field measurements from the CHAMP satellite during July 2000 to September 2010 and from the two Swarm satellites during November 2013 to February 2017 to determine, for the first time, the complete seasonal-longitudinal climatology of the semidiurnal lunar tidal variation in the equatorial electrojet intensity. Significant longitudinal variability is found in the amplitude of the lunar tidal variation, while the longitudinal variability in the phase is small. The amplitude peaks in the Peruvian sector (˜285°E) during the Northern Hemisphere winter and equinoxes, and in the Brazilian sector (˜325°E) during the Northern Hemisphere summer. There are also local amplitude maxima at ˜55°E and ˜120°E. The longitudinal variation is partly due to the modulation of ionospheric conductivities by the inhomogeneous geomagnetic field. Another possible cause of the longitudinal variability is neutral wind forcing by nonmigrating lunar tides. A tidal spectrum analysis of the semidiurnal lunar tidal variation in the equatorial electrojet reveals the dominance of the westward propagating mode with zonal wave number 2 (SW2), with secondary contributions by westward propagating modes with zonal wave numbers 3 (SW3) and 4 (SW4). Eastward propagating waves are largely absent from the tidal spectrum. Further study will be required for the relative importance of ionospheric conductivities and nonmigrating lunar tides.

  4. New Measurements Of Jupiter's Equatorial Region In Visible Wavelengths

    Science.gov (United States)

    Rojas, Jose; Arregi, J.; García-Melendo, E.; Barrado-Izagirre, N.; Hueso, R.; Gómez-Forrellad, J. M.; Pérez-Hoyos, S.; Sanz-Requena, J. F.; Sánchez-Lavega, A.

    2010-10-01

    We have studied the equatorial region of Jupiter, between 15ºS and 15ºN, on Cassini ISS images obtained during the Jupiter flyby at the end of 2000 and on HST images acquired in May and July 2008. We have found significant longitudinal variations in the intensity of the 6ºN eastward jet, up to 60 m s-1 in Cassini and HST observations. In the HST case we found that these longitudinal variations are associated to different cloud morphology. Photometric and radiative transfer analysis of the cloud features used as tracers in HST images shows that there is only a small height difference, no larger than 0.5 - 1 scale heights at most, between the slow ( 100 m s-1) and fast ( 150 m s-1) moving features. This suggests that speed variability at 6ºN is not dominated by vertical wind shears and we propose that Rossby wave activity is the responsible for the zonal variability. After removing this variability we found that Jupiter's equatorial jet is actually symmetric relative to the equator with two peaks of 140 - 150 m s-1 located at latitudes 6ºN and 6ºS and at a similar pressure level. We also studied a large, long-lived feature called the White Spot (WS) located at 6ºS that turns to form and desapear. The internal flow field in the White Spot indicates that it is a weakly rotating quasi-equatorial anticyclone relative to the ambient meridionally sheared flow. Acknowledgements: This work was supported by the Spanish MICIIN AYA2009-10701 with FEDER and Grupos Gobierno Vasco IT-464-07.

  5. Discovery Of A Rossby Wave In Jupiter's South Equatorial Region

    Science.gov (United States)

    Simon-Miller, Amy A.; Choi, D. S.; Rogers, J. H.; Gierasch, P. J.

    2012-01-01

    A detailed study of the chevron-shaped dark spots on the strong southern equatorial wind jet near 7.5 deg S planetographic latitude shows variations in velocity with longitude and time. The chevrons move with velocities near the maximum wind jet velocity of approx.140 m/s, as deduced by the history of velocities at this latitude and the magnitude of the symmetric wind jet near 7 deg N latitude. Their repetitive nature is consistent with an inertia-gravity wave (n = 75-100) with phase speed up to 25 m/s, relative to the local flow, but the identity of this wave mode is not well constrained. However, high spatial resolution movies from Cassini images show that the chevrons oscillate in latitude with a approx.7-day period. This oscillating motion has a wavelength of approx.20 deg and a speed of approx.100 m/s, following a pattern similar to that seen in the Rossby wave plumes of the North Equatorial Zone, and possibly reinforced by it, though they are not perfectly in phase. The transient anticyclonic South Equatorial Disturbance (SED) may be a similar wave feature, but moves at slower velocity. All data show chevron latitude variability, but it is unclear if this Rossby wave is present during other epochs, without time series movies that fully delineate it. In the presence of multiple wave modes, the difference in dominant cloud appearance between 7 deg N and 7.5 deg S may be due to the presence of the Great Red Spot, either through changes in stratification and stability or by acting as a wave boundary.

  6. Regulation of primary productivity rate in the equatorial Pacific

    International Nuclear Information System (INIS)

    Barber, R.T.; Chavez, F.P.

    1991-01-01

    Analysis of the Chl-specific rate of primary productivity (P B ) as a function of subsurface nutrient concentration at >300 equatorial stations provides an answer to the question: What processes regulate primary productivity rate in the high-nutrient, low-chlorophyll waters of the equatorial Pacific? In the western Pacific where there is a gradient in 60-m [NO 3 ] from 0 to ∼12 μM, the productivity rate is a linear function of nutrient concentration; in the eastern Pacific where the gradient is from 12 to 28 μM, the productivity rate is independent of nutrient concentration and limited to ∼36 mg C(mg Chl) -1 d -1 , or a mean euphotic zone C-specific growth rate (μ) of 0.47 d -1 . However, rates downstream of the Galapagos Islands are not limited; they are 46.4 mg C(mg Chl) -1 d -1 and μ = 0.57 d -1 , very close to the predicted nutrient-regulated rates in the absence of other limitation. This pattern of rate regulation can be accounted for by a combination of eolian Fe, subsurface nutrients, and sedimentary Fe derived from the Galapagos platform. In the low-nutrient western Pacific the eolian supply of Fe is adequate to allow productivity rate to be set by subsurface nutrient concentration. In the nutrient-rich easter equatorial region eolian Fe is inadequate to support productivity rates proportional to the higher nutrient concentrations, so in this region eolian Fe is rate limiting. Around the Galapagos Islands productivity rates reach levels consistent with nutrient concentrations; sedimentary Fe from the Galapagos platform seems adequate to support increased nutrient-regulated productivity rates in this region

  7. Equatorial storm sudden commencements and interplanetary magnetic field

    International Nuclear Information System (INIS)

    Rastogi, R.G.

    1980-01-01

    A comparison is made of the signatures of interplanetary (IP) shocks in the B and theta plots of interplanetary magnetic field (IMF) data of satellites Explorer 33, 34 and 35 and in the H magnetograms at ground observatories within the equatorial electrojet belt, Huancayo, Addis Ababa and Trivandrum associated with major storm sudden commencements during 1967-70. The IP shocks showing sudden increase of the scalar value of IMF, i.e. B without any change of the latitude theta or with the southward turning of theta, were followed by a purely positive sudden increase of H, at any of the magnetic observatories, either on the dayside or the nightside of the earth. The IP shocks identified by a sudden increase of B and with the northward turning of the latitude theta (positive ΔBsub(z)) were associated with purely positive sudden commencement (SC) at the observatories in the nightside, but at the equatorial observatories in the dayside of the earth the signature of the shock was a SC in H with a preliminary negative impulse followed by the main positive excursion (SC-+). It is suggested that the SCs in H at low latitudes are composed of two effects, viz. (i) one due to hydromagnetic pressure on the magnetosphere by the solar plasma and (ii) the other due to the induced electric field associated with the solar wind velocity, V and the Z-component of the IP magnetic field (E = - V x Bsub(z)). The effect of magnetosphere electric field is faster than the effect due to the compression of the magnetosphere by the impinging solar plasma. The negative impulse of SC-+ at low latitude is seen at stations close to the dip equator and only during daytime due to the existence of high ionospheric conductivities in the equatorial electrojet region. (author)

  8. The Effect of the Equatorial Environment on Oxo-Group Silylation of the Uranyl Dication: A Computational Study

    International Nuclear Information System (INIS)

    Yahia, A.; Maron, L.; Yahia, A.; Arnold, P.L.; Love, J.B.

    2010-01-01

    A theoretical investigation of the reductive oxo-group silylation reaction of the uranyl dication held in a Pacman macrocyclic environment has been carried out. The effect of the modeling of the Pacman ligand on the reaction profiles is found to be important, with the dipotassiation of a single oxo group identified as a key component in promoting the reaction between the Si-X and uranium-oxo bonds. This reductive silylation reaction is also proposed to occur in an aqueous environment but was found not to operate on bare ions; in this latter case, substitution of a ligand in the equatorial plane was the most likely reaction. These results demonstrate the importance of the presence but not the identity of the equatorial ligands upon the silylation of the uranyl U-O bond. (authors)

  9. Daily observations of the development of the ionospheric equatorial anomaly by means of differential Doppler shift method

    International Nuclear Information System (INIS)

    Huang, Y.N.; Cheng, K.; Chen, S.W.

    1987-01-01

    The differential Doppler frequency shifts observed by receiving coherent radio signals at frequencies of 150 and 400 MHz transmitted from the polar orbiting satellites of U.S. Navy Navigation Satellite System have been used to deduce the latitudinal variations of the ionospheric total electron content (TEC) near the ionospheric equatorial anomaly crest region. All latitudinal variations of TEC thus obtained for each passage of an NNSS satellite are used to construct daily contour plots of TEC in a latitude versus local time coordinates. It has been shown that these contour plot of TEC can be used to investigate the behavior of TEC around equatorial anomaly crest region. Some results are presented and discussed. 18 references

  10. Electromagnetic analysis of ITER diagnostic equatorial port plugs during plasma disruptions

    International Nuclear Information System (INIS)

    Zhai, Y.; Feder, R.; Brooks, A.; Ulrickson, M.; Pitcher, C.S.; Loesser, G.D.

    2013-01-01

    Highlights: ► Disruption loads on ITER diagnostic equatorial port plugs are extracted. ► Upward major disruption produces the largest radial moment and radial force on diagnostic first walls and diagnostic shield modules. ► Large eddy currents on supporting rails, keys and water pipes are observed during disruption. -- Abstract: ITER diagnostic port plugs perform many functions including structural support of diagnostic systems under high electromagnetic loads while allowing for diagnostic access to the plasma. The design of diagnostic equatorial port plugs (EPP) are largely driven by electromagnetic loads and associate responses of EPP structure during plasma disruptions and VDEs. This paper summarizes results of transient electromagnetic analysis using Opera 3d in support of the design activities for ITER diagnostic EPP. A complete distribution of disruption loads on the diagnostic first walls (DFWs), diagnostic shield modules (DSMs) and the EPP structure, as well as impact on the system design integration due to electrical contact among various EPP structural components are discussed

  11. Radar Observations of 8.3-m scale equatorial spread F irregularities over Trivandrum

    Directory of Open Access Journals (Sweden)

    D. Tiwari

    2004-03-01

    Full Text Available In this paper, we present observations of equatorial spread F (ESF irregularities made using a newly installed 18MHz radar located at Trivandrum. We characterize the morphology and the spectral parameters of the 8.3-m ESF irregularities which are found to be remarkably different from that observed so extensively at the 3-m scale size. We also present statistical results of the irregularities in the form of percentage occurrence of the echoes and spectral parameters (SNR, Doppler velocity, Spectral width. The Doppler spectra are narrower, less structured and less variable in time as compared to those observed for 3-m scale size. We have never observed the ESF irregularity velocities to be supersonic here unlike those at Jicamarca, and the velocities are found to be within ±200ms–1. The spectral widths are found to be less than 150ms–1. Hence, the velocities and spectral width both are smaller than those reported for 3-m scale size. The velocities and spectral widths are further found to be much smaller than those of the American sector. These observations are compared with those reported elsewhere and discussed in the light of present understanding on the ESF irregularities at different wavelengths.

    Key words. Ionoshphere (equatorial ionosphere, plasma waves and instabilities; ionospheric irregularities

  12. Radar Observations of 8.3-m scale equatorial spread F irregularities over Trivandrum

    Directory of Open Access Journals (Sweden)

    D. Tiwari

    2004-03-01

    Full Text Available In this paper, we present observations of equatorial spread F (ESF irregularities made using a newly installed 18MHz radar located at Trivandrum. We characterize the morphology and the spectral parameters of the 8.3-m ESF irregularities which are found to be remarkably different from that observed so extensively at the 3-m scale size. We also present statistical results of the irregularities in the form of percentage occurrence of the echoes and spectral parameters (SNR, Doppler velocity, Spectral width. The Doppler spectra are narrower, less structured and less variable in time as compared to those observed for 3-m scale size. We have never observed the ESF irregularity velocities to be supersonic here unlike those at Jicamarca, and the velocities are found to be within ±200ms–1. The spectral widths are found to be less than 150ms–1. Hence, the velocities and spectral width both are smaller than those reported for 3-m scale size. The velocities and spectral widths are further found to be much smaller than those of the American sector. These observations are compared with those reported elsewhere and discussed in the light of present understanding on the ESF irregularities at different wavelengths. Key words. Ionoshphere (equatorial ionosphere, plasma waves and instabilities; ionospheric irregularities

  13. Growth rates, grazing, sinking, and iron limitation of equatorial Pacific phytoplankton

    International Nuclear Information System (INIS)

    Chavez, F.P.; Buck, K.R.; Coale, K.H.; Martin, J.H.; DiTullio, G.R.; Welschmeyer, N.A.; Barber, R.T.; Jacobson, A.C.

    1991-01-01

    Concentrations of phytoplankton and NO 3 are consistently low and high in surface waters of the oceanic eastern and central equatorial Pacific, and phytoplankton populations are dominated by small solitary phytoplankton. Growth rates of natural phytoplankton populations, needed to assess the relative importance of many of the processes considered in the equatorial Pacific, were estimated by several methods. The growth rates of natural phytoplankton populations were found to be ∼0.7 d -1 or 1 biomass doubling d -1 and were similar for all methods. To keep this system in its observed balance requires that loss rates approximate observed growth rates. Grazing rates, measured with a dilution grazing experiment, were high, accounting for a large fraction of the daily production. Additions of various forms of Fe to 5-7-d incubations utilizing ultraclean techniques resulted in significant shifts in autotrophic and heterotrophic assemblages between initial samples, controls, and Fe enrichments, which were presumably due to Fe, grazing by both protistan and metazoan components, and incubation artifacts. Estimated growth rates of small pennate diatoms showed increases in Fe enrichments with respect to controls. The growth rates of the pennate diatoms were similar to those estimated for the larger size fraction of the natural populations

  14. An Analysis of Cassini Observations Regarding the Structure of Jupiter's Equatorial Atmosphere

    Science.gov (United States)

    Choi, David S.; Simon-Miller, Amy A.

    2012-01-01

    A variety of intriguing atmospheric phenomena reside on both sides of Jupiter's equator. 5-micron bright hot spots and opaque plumes prominently exhibit dynamic behavior to the north, whereas compact, dark chevron-shaped features and isolated anticyclonic disturbances periodically occupy the southern equatorial latitudes. All of these phenomena are associated with the vertical and meridional perturbations of Rossby waves disturbing the mean atmospheric state. As previous observational analysis and numerical simulations have investigated the dynamics of the region, an examination of the atmosphere's vertical structure though radiative transfer analysis is necessary for improved understanding of this unique environment. Here we present preliminary analysis of a multispectral Cassini imaging data set acquired during the spacecraft's flyby of Jupiter in 2000. We evaluated multiple methane and continuum spectral channels at available viewing angles to improve constraints on the vertical structure of the haze and cloud layers comprising these interesting features. Our preliminary results indicate distinct differences in the structure for both hemispheres. Upper troposphere hazes and cloud layers are prevalent in the northern equatorial latitudes, but are not present in corresponding southern latitudes. Continued analysis will further constrain the precise structure present in these phenomena and the differences between them.

  15. Contribution of storm time substorms to the prompt electric field disturbances in the equatorial ionosphere

    International Nuclear Information System (INIS)

    Hui, Debrup; Chakrabarty, D.; Sekar, R.; Reeves, G. D.

    2017-01-01

    This study tries to bring out the fact that storm time substorms can compete and at times significantly contribute to the geomagnetically disturbed time prompt penetration electric field effects on low and equatorial latitudes. Observations of unusual equatorial plasma drift data from Jicamarca Unattended Long-term Investigations of the Ionosphere and Atmosphere during two space weather events show that substorms can induce both eastward and westward penetration electric fields under steady southward interplanetary magnetic field (IMF B z ) conditions. During the first event on 2 January 2005, the enhancement of the daytime eastward electric field over Jicamarca due to substorm is found to be comparable with the Sq and interplanetary electric field (IEFy) generated electric fields combined. During the second event on 19 August 2006, the substorm is seen to weaken the daytime eastward field thereby inducing a westward field in spite of the absence of northward turning of IMF B z (overshielding). The westward electric field perturbation in the absence of any overshielding events is observationally sparse and contrary to the earlier results. Further, the substorm-induced field is found to be strong enough to compete or almost nullify the effects of storm time IEFy fields. This study also shows quantitatively that at times substorm contribution to the disturbed time prompt electric fields can be significant and thus should be taken into consideration in evaluating penetration events over low latitudes.

  16. The evolution of the equatorial thermocline and the early Pliocene El Padre mean state

    Science.gov (United States)

    Ford, Heather L.; Ravelo, A. Christina; Dekens, Petra S.; LaRiviere, Jonathan P.; Wara, Michael W.

    2015-06-01

    The tropical Pacific thermocline strength, depth, and tilt are critical to tropical mean state and variability. During the early Pliocene (~3.5 to 4.5 Ma), the Eastern Equatorial Pacific (EEP) thermocline was deeper and the cold tongue was warmer than today, which resulted in a mean state with a reduced zonal sea surface temperature gradient or El Padre. However, it is unclear whether the deep thermocline was a local feature of the EEP or a basin-wide condition with global implications. Our measurements of Mg/Ca of Globorotalia tumida in a western equatorial Pacific site indicate Pliocene subsurface temperatures warmer than today; thus, El Padre included a basin-wide thermocline that was relatively warm, deep, and weakly tilted. At ~4 Ma, thermocline steepening was coupled to cooling of the cold tongue. Since ~4 Ma, the basin-wide thermocline cooled/shoaled gradually, with implications for thermocline feedbacks in tropical dynamics and the interpretation of TEX86-derived temperatures.

  17. Variabilities of mesospheric tides and equatorial electrojet strength during major stratospheric warming events

    Directory of Open Access Journals (Sweden)

    S. Sridharan

    2009-11-01

    Full Text Available The present study demonstrates the relationship between the high latitude northern hemispheric major sudden stratospheric warming (SSW events and the reversal in the afternoon equatorial electrojet (EEJ, often called the counter-electrojet (CEJ, during the winter months of 1998–1999, 2001–2002, 2003–2004 and 2005–2006. As the EEJ current system is driven by tidal winds, an investigation of tidal variabilities in the MF radar observed zonal winds during the winters of 1998–1999 and 2005–2006 at 88 km over Tirunelveli, a site close to the magnetic equator, shows that there is an enhancement of semi-diurnal tidal amplitude during the days of a major SSW event and a suppression of the same immediately after the event. The significance of the present results lies in demonstrating the latitudinal coupling between the high latitude SSW phenomenon and the equatorial ionospheric current system with clear evidence for major SSW events influencing the day-to-day variability of the CEJ.

  18. Equatorial Precession Drove Mid-Latitude Changes in ENSO-Scale Variation in the Earliest Miocene

    Science.gov (United States)

    Fox, B.; D'Andrea, W. J.; Lee, D. E.; Wilson, G. S.

    2014-12-01

    Foulden Maar is an annually laminated lacustrine diatomite deposit from the South Island of New Zealand. The deposit was laid down over ~100 kyr of the latest Oligocene and earliest Miocene, during the peak and deglaciation phase of the Mi-1 Antarctic glaciation event. At this time, New Zealand was located at approximately the same latitude as today (~45°S). Evidence from organic geochemical proxies (δD, δ13C) and physical properties (density, colour) indicates the presence of an 11-kyr cycle at the site. Although it is known that 11-kyr insolation (half-precession) cycles occur between the Tropics, this cycle is rarely seen in sedimentary archives deposited outside the immediate vicinity of the Equator. Records from Foulden Maar correlate well with the amplitude and phase of the modelled equatorial half-precession cycle for the earliest Miocene. High-resolution (50 µm) colour intensity measurements and lamina thickness measurements both indicate the presence of significant ENSO-like (2-8 year) variation in the Foulden Maar sediments. Early results from targeted lamina thickness measurements suggest that ENSO-band variation is modulated by the 11-kyr cycle, with power in the ENSO band increasing during periods of increased insolation at the Equator. This implies that equatorial half-precession had a significant effect on ENSO-like variation in the early Miocene, and that this effect was felt as far afield as the mid-latitudes of the Southern Hemisphere.

  19. Electromagnetic analysis of ITER generic equatorial port plug designs during three plasma current disruption cases

    International Nuclear Information System (INIS)

    Guirao, J.; Rodríguez, E.; Ordieres, J.; Cabanas, M.F.; García, C.H. Rojas

    2012-01-01

    Highlights: ► Electromagnetic transient performance evaluation of the GEPP structure. ► Three different plasma current disruption cases: MD UP LIN36, VDE UP LIN36 and VDE DW LIN36 were analyzed. ► Three DSM-First Wall (FW) designs (horizontal and vertical drawers and monoblock) were compared. - Abstract: Electromagnetic phenomena due to plasma current disruptions are the cause for the main mechanical operation loads over the ITER equatorial level port plug structures. This paper presents a detailed finite element simulation and analysis of the transient electromagnetic effects of three different plasma current disruption cases over three designs of diagnostic shielding module (DSM) structure. The DSMs are contained into and supported by the generic equatorial port plug (GEPP) analyzed structure. The three plasma disruption cases studied were: major disruption upwards linear decay in 36 ms (MD UP LIN36), vertical displacements events, upwards and downwards linear decay in 36 ms (VDE UP LIN36 and VDE DW LIN36). A detailed analysis for GEPP structure and three DSM-first wall (FW) designs (horizontal and vertical drawers and monoblock) is also presented in order to extract the Eddy current distribution on these devices and thus the resultant electromagnetic forces and moments acting on them.

  20. Filamentary Alfvénic structures excited at the edges of equatorial plasma bubbles

    Directory of Open Access Journals (Sweden)

    R. Pottelette

    2007-11-01

    Full Text Available Recent observations performed by the French DEMETER satellite at altitudes of about 710 km suggest that the generation of equatorial plasma bubbles correlates with the presence of filamentary structures of field aligned currents carried by Alfvén waves. These localized structures are located at the bubble edges. We study the dynamics of the equatorial plasma bubbles, taking into account that their motion is dictated by gravity driven and displacement currents. Ion-polarization currents appear to be crucial for the accurate description of the evolution of plasma bubbles in the high altitude ionosphere. During their eastward/westward motion the bubbles intersect gravity driven currents flowing transversely with respect to the background magnetic field. The circulation of these currents is prohibited by large density depressions located at the bubble edges acting as perfect insulators. As a result, in these localized regions the transverse currents have to be locally closed by field aligned currents. Such a physical process generates kinetic Alfvén waves which appear to be stationary in the plasma bubble reference frame. Using a two-dimensional model and "in situ" wave measurements on board the DEMETER spacecraft, we give estimates for the magnitude of the field aligned currents and the associated Alfvén fields.

  1. Variability in equatorial B0 and B1

    International Nuclear Information System (INIS)

    Adeniyi, J.O.; Radicella, S.M.

    2002-01-01

    Variability of ionospheric profile parameters B0 and B1, below the F2 peak is investigated for an equatorial station at two levels of solar activities. The whole 24 hours of the day and the four seasons of the year are covered. Absolute and relative variability indices were utilized in the study. Some evidences of correlations of variability index and profiles parameters were observed. Daytime values of relative variability in B1 at solar minimum were found to be greater than those of solar maximum. (author)

  2. Hypervitaminosis D and Metastatic Calcification in a Colony of Inbred Strain 13 Guinea Pigs, Cavia porcellus.

    Science.gov (United States)

    Holcombe, H; Parry, N M; Rick, M; Brown, D E; Albers, T M; Refsal, K R; Morris, J; Kelly, R; Marko, S T

    2015-07-01

    A commercial diet fed to a colony of inbred strain 13 guinea pigs for approximately 6 weeks was subsequently recalled for excessive levels of vitamin D. Twenty-one of 62 animals exhibited clinical signs, including anorexia, lethargy, and poor body condition. Nine affected and 4 clinically normal animals were euthanized for further evaluation, including serum chemistry, urinalysis, and gross and/or histopathology. Macroscopic findings included white discoloration in multiple organs in 8 animals, and microscopic evaluation confirmed multiorgan mineralization in tissues from 7 animals. Serum 25-hydroxyvitamin D levels were elevated in 10 animals. Serum inorganic phosphorus and alkaline phosphatase levels were increased in all exposed animals; however, total calcium and ionized calcium levels were not significantly higher in exposed animals than in control strain 13 guinea pigs from a different institution. The data support a diagnosis of hypervitaminosis D with metastatic calcification. Following the diet recall, the remaining guinea pigs increased their food intake and regained body condition. Diagnostic testing of 8 animals euthanized approximately 3 months after returning to a normal diet demonstrated that serum parathyroid hormone remained significantly lower, and ionized calcium and ionized magnesium were significantly higher, in recovered animals compared to controls and exposed animals. These results indicate that diagnostic tests other than serum calcium are necessary for a diagnosis of hypervitaminosis D in guinea pigs. © The Author(s) 2014.

  3. Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs.

    Science.gov (United States)

    Kozan, Günay; Aktan, Bülent; Sakat, Muhammed Sedat; Kurt, Sezgin; Öner, Fatih; Kara, Adem

    2015-01-01

    The results of the study showed that clarithromycin has anti-inflammatory and antioxidant effects and, when it is combined with prednisolone, those effects gain strength. The present study aims to investigate the effects that the antioxidant and anti-inflammatory activities of clarithromycin and/or prednisolone have on experimental otitis media in effusion-induced guinea-pigs. In this study, 35-male guinea pigs were randomly divided into five-groups. For the experimental otitis media, intra-tympanic histamine (0.1 ml) was injected into the guinea pigs in all of the groups except the control group. Then, 24-h after the intra-tympanic injections, clarithromycin (15 mg/kg/day) and/or prednisolone (1 mg/kg/day) were applied intraperitoneally to the guinea-pigs for 7-days. The biochemical analysis showed an increase in antioxidant capacity and a decrease in oxidant status and malondialdehyde (MDA) levels in the clarithromycin group and the prednisolone group and especially in the clarithromycin+prednisolone group, as compared to the experimental group (p < 0.05). In the cytokine analysis, lower levels of interleukin (IL)-6 and IL-17A and higher IL-10 were found in the clarithromycin, prednisolone, and clarithromycin+prednisolone groups than in the experimental group (p < 0.05). Furthermore, the histologic analyses showed histopathologic changes in the middle ear mucosa of the experimental group, but comparatively fewer-histopathologic changes were observed in the clarithromycin, prednisolone, and clarithromycin+prednisolone groups.

  4. Use of a Far-Infrared Active Warming Device in Guinea Pigs (Cavia porcellus).

    Science.gov (United States)

    Zarndt, Bethany S; Buchta, Jessica N; Garver, Lindsey S; Davidson, Silas A; Rowton, Edgar D; Despain, Kenneth E

    2015-11-01

    Small mammals have difficulty maintaining body temperature under anesthesia. This hypothermia is a potential detriment not only to the health and comfort of the animal but also to the integrity of any treatment given or data gathered during the anesthetic period. Using an external warming device to assist with temperature regulation can mitigate these effects. In this study, we investigated the ability of an advanced warming device that uses far-infrared (FIR) heating and responds to real-time core temperature monitoring to maintain a normothermic core temperature in guinea pigs. Body temperatures were measured during 30 min of ketamine-xylazine general anesthesia with and without application of the heating device. The loss of core body heat from anesthetized guinea pigs under typical (unwarmed) conditions was significant, and this loss was almost completely mitigated by application of the FIR heating pad. The significant difference between the temperatures of the actively warmed guinea pigs as compared with the control group began as early as 14 min after anesthetic administration, leading to a 2.6 °C difference at 30 min. Loss of core body temperature was not correlated with animals' body weight; however, weight influences the efficiency of FIR warming slightly. These study results show that the FIR heating device accurately controls core body temperature in guinea pigs, therefore potentially alleviating the effects of body heat loss on animal physiology.

  5. Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs.

    Science.gov (United States)

    Tate, Alan D; Antonelli, Patrick J; Hannabass, Kyle R; Dirain, Carolyn O

    2017-03-01

    Objective To determine if mitoquinone (MitoQ) attenuates cisplatin-induced hearing loss in guinea pigs. Study Design Prospective and controlled animal study. Setting Academic, tertiary medical center. Subjects and Methods Guinea pigs were injected subcutaneously with either 5 mg/kg MitoQ (n = 9) or normal saline (control, n = 9) for 7 days and 1 hour before receiving a single dose of 10 mg/kg cisplatin. Auditory brainstem response thresholds were measured before MitoQ or saline administration and 3 to 4 days after cisplatin administration. Results Auditory brainstem response threshold shifts after cisplatin treatment were smaller by 28 to 47 dB in guinea pigs injected with MitoQ compared with those in the control group at all tested frequencies (4, 8, 16, and 24 kHz, P = .0002 to .04). Scanning electron microscopy of cochlear hair cells showed less outer hair cell loss and damage in the MitoQ group. Conclusion MitoQ reduced cisplatin-induced hearing loss in guinea pigs. MitoQ appears worthy of further investigation as a means of preventing cisplatin ototoxicity in humans.

  6. Biodiversity inventories and conservation of the marine fishes of Bootless Bay, Papua New Guinea

    Science.gov (United States)

    2012-01-01

    Background The effective management and conservation of biodiversity is predicated on clearly defined conservation targets. Species number is frequently used as a metric for conservation prioritization and monitoring changes in ecosystem health. We conducted a series of synoptic surveys focusing on the fishes of the Bootless Bay region of Papua New Guinea to generate a checklist of fishes of the region. Bootless Bay lies directly south of Port Moresby, the capital of Papua New Guinea, and experiences the highest human population density of any marine area in the country. Our checklist will set a baseline against which future environmental changes can be tracked. Results We generated a checklist of 488 fish species in 72 families found in Bootless Bay during a two-week sampling effort. Using incident-based methods of species estimation, we extrapolate there to be approximately 940 fish species in Bootless Bay, one of the lowest reported numbers in Papua New Guinea. Conclusions Our data suggest that the Bootless Bay ecosystem of Papua New Guinea, while diverse in absolute terms, has lower fish biodiversity compared to other shallow marine areas within the country. These differences in faunal diversity are most likely a combination of unequal sampling effort as well as biophysical factors within Bootless Bay compounded by historical and/or contemporary anthropogenic disturbances. PMID:22849436

  7. Biodiversity inventories and conservation of the marine fishes of Bootless Bay, Papua New Guinea

    Directory of Open Access Journals (Sweden)

    Drew Joshua A

    2012-08-01

    Full Text Available Abstract Background The effective management and conservation of biodiversity is predicated on clearly defined conservation targets. Species number is frequently used as a metric for conservation prioritization and monitoring changes in ecosystem health. We conducted a series of synoptic surveys focusing on the fishes of the Bootless Bay region of Papua New Guinea to generate a checklist of fishes of the region. Bootless Bay lies directly south of Port Moresby, the capital of Papua New Guinea, and experiences the highest human population density of any marine area in the country. Our checklist will set a baseline against which future environmental changes can be tracked. Results We generated a checklist of 488 fish species in 72 families found in Bootless Bay during a two-week sampling effort. Using incident-based methods of species estimation, we extrapolate there to be approximately 940 fish species in Bootless Bay, one of the lowest reported numbers in Papua New Guinea. Conclusions Our data suggest that the Bootless Bay ecosystem of Papua New Guinea, while diverse in absolute terms, has lower fish biodiversity compared to other shallow marine areas within the country. These differences in faunal diversity are most likely a combination of unequal sampling effort as well as biophysical factors within Bootless Bay compounded by historical and/or contemporary anthropogenic disturbances.

  8. Modeling production functions and economic weights in intensive meat production of guinea pigs.

    Science.gov (United States)

    Pascual, Mariam; Cruz, Danny Julio; Blasco, Agustín

    2017-10-01

    A profit function for a typical commercial farm of intensive guinea pig production was designed. The simulated farm contained 86 cages with a ratio of 7:1 females/males, with continuous mating. Kits were weaned at 15 days of age and slaughtered for meat production at 90 days of age. The absolute (EW) and relative economic weights of the main traits were calculated. The highest EW were kits produced per kindling (US$25), kits weaned per kindling (US$22), kits born alive per kindling (US$20), and the number of kindlings per female and year (US$12). Profit, returns, and costs per female and year were US$15, 68, and 53, respectively. Returns came from the production of young guinea pigs and discarded reproductive adults for meat production, 90 and 10% of the total returns. The highest costs were feeding and labor, 44 and 23% of the total cost. The EW and profit did not substantially change when simulating variations of ±20% in the prices of kilograms of fattening feed and kilograms of live weight of guinea pig, showing their robustness to future variations in market prices or to variations in prices between countries. The results obtained highlight the importance of the feeding costs in the guinea pig meat production.

  9. Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis.

    Science.gov (United States)

    Brozmanova, M; Plevkova, J; Tatar, M; Kollarik, M

    2008-12-01

    Increased cough reflex sensitivity is found in patients with allergic rhinitis and may contribute to cough caused by rhinitis. We have reported that cough to citric acid is enhanced in the guinea pig model of allergic rhinitis. Here we address the hypothesis that the cough reflex sensitivity is increased in this model. The data from our previous studies were analyzed for the cough reflex sensitivity. The allergic inflammation in the nose was induced by repeated intranasal instillations of ovalbumin in the ovalbumin-sensitized guinea pigs. Cough was induced by inhalation of doubling concentrations of citric acid (0.05-1.6 M). Cough threshold was defined as the lowest concentration of citric acid causing two coughs (C2, expressed as geometric mean [95% confidence interval]). We found that the cough threshold was reduced in animals with allergic rhinitis. C2 was 0.5 M [0.36-0.71 M] and 0.15 M [0.1-0.23 M] prior and after repeated intranasal instillations of ovalbumin, respectively, Preflex sensitivity. C2 was reduced in animals with allergic rhinitis treated orally with vehicle (0.57 M [0.28-1.1] vs. 0.09 M [0.04-0.2 M], Preflex sensitivity is increased in the guinea pig model of allergic rhinitis. Our results suggest that guinea pig is a suitable model for mechanistic studies of increased cough reflex sensitivity in rhinitis.

  10. Effects of single dose X-irradiation on the guinea-pig spinal cord

    Energy Technology Data Exchange (ETDEWEB)

    Knowles, J F [Medical Research Council, Harwell (UK). Radiobiological Research Unit

    1981-09-01

    Lumbar or cervical regions of the guinea-pig spinal cord were irradiated with a single dose of 250 kV X-rays. The latency for paralysis, whether of hind- or fore-limbs, and the histopathology of the radiation-induced cord lesions depended critically on the radiation dose. There were definite but only minor differences between the reactions of lumbar and cervical cord to the same radiation dose. After 30 or 40 Gy there was white matter necrosis but after 20 Gy widespread demyelination associated with vacuolar spaces occurred. After irradiation of the lumbar cord with 30-40 Gy, the lesions in the guinea-pig differed from those reported in the rat. White-matter necrosis in the guinea-pig cord was only occasionally associated with spinal nerve root necrosis, whereas in the rat, nerve-root necrosis with sparing of the white matter was the main lesion. After 20 Gy to the cervical or lumbar cord the guinea-pig showed widespread demyelination and vacuolation whereas in rats vascular lesions were the main result.

  11. High-dose ascorbic acid decreases cholesterolemic factors of an atherogenic diet in guinea pigs.

    Science.gov (United States)

    Filis, Konstantinos; Anastassopoulou, Aikaterini; Sigala, Fragiska; Theodorou, Dimitrios; Manouras, Andreas; Leandros, Emanouel; Sigalas, Panagiotis; Hepp, Wolfgang; Bramis, John

    2007-03-01

    The study evaluates the effect of a high supplemental dose of ascorbic acid (AA) on plasma concentrations of total cholesterol (TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions high-density, very-low-density-, and low-density lipoprotein (HDL, VLDL, LDL) in guinea pigs fed with atherogenic diet. Group I consisted of 5 normally fed guinea pigs plus a low dose of AA (1 mg/100 g/day), group II consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a low dose of AA (1 mg/100 g/day), and group III consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a high dose of AA (30 mg/100 g/day). Cholesterolemic factors concentrations were determined after nine weeks. Concentrations of TC, TG, TL, LDL, and VLDL were increased in group II compared to group I (p < 0.01 for all differences). Supplementation with a high dose of AA resulted in decreased concentrations of TC (p < 0.01), TG (p < 0.01), TL (p < 0.01), and LDL (p < 0.01) in group III compared to group II. Additionally, concentration of HDL was increased in group III compared to group II (p < 0.01). High-dose AA supplementation to an atherogenic diet decreases concentrations of TC, TG, TL, and LDL and increases concentration of HDL compared to low-dose AA.

  12. Catecholamine secretion by chemical hypoxia in guinea-pig, but not rat, adrenal medullary cells: differences in mitochondria.

    Science.gov (United States)

    Harada, K; Endo, Y; Warashina, A; Inoue, M

    2015-08-20

    The effects of mitochondrial inhibitors (CN(-), a complex IV inhibitor and CCCP, protonophore) on catecholamine (CA) secretion and mitochondrial function were explored functionally and biochemically in rat and guinea-pig adrenal chromaffin cells. Guinea-pig chromaffin cells conspicuously secreted CA in response to CN(-) or CCCP, but rat cells showed a little, if any, secretory response to either of them. The resting metabolic rates in rat adrenal medullae did not differ from those in guinea-pig adrenal medullae. On the other hand, the time course of depolarization of the mitochondrial membrane potential (ΔΨm) in guinea-pig chromaffin cells in response to CN(-) was slower than that in rat chromaffin cells, and this difference was abolished by oligomycin, an F1F0-ATPase inhibitor. The extent of CCCP-induced decrease in cellular ATP in guinea-pig chromaffin cells, which was indirectly measured using a Mg(2+) indicator, was smaller than that in rat chromaffin cells. Relative expression levels of F1F0-ATPase inhibitor factor in guinea-pig adrenal medullae were smaller than in rat adrenal medullae, and the opposite was true for F1F0-ATPase α subunit. The present results indicate that guinea-pig chromaffin cells secrete more CA in response to a mitochondrial inhibitor than rat chromaffin cells and this higher susceptibility in the former is accounted for by a larger extent of reversed operation of F1F0-ATPase with the consequent decrease in ATP under conditions where ΔΨm is depolarized. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  13. Biogeography and potential exchanges among the atlantic Equatorial belt cold-seep faunas.

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    Karine Olu

    2010-08-01

    Full Text Available Like hydrothermal vents along oceanic ridges, cold seeps are patchy and isolated ecosystems along continental margins, extending from bathyal to abyssal depths. The Atlantic Equatorial Belt (AEB, from the Gulf of Mexico to the Gulf of Guinea, was one focus of the Census of Marine Life ChEss (Chemosynthetic Ecosystems program to study biogeography of seep and vent fauna. We present a review and analysis of collections from five seep regions along the AEB: the Gulf of Mexico where extensive faunal sampling has been conducted from 400 to 3300 m, the Barbados accretionary prism, the Blake ridge diapir, and in the Eastern Atlantic from the Congo and Gabon margins and the recently explored Nigeria margin. Of the 72 taxa identified at the species level, a total of 9 species or species complexes are identified as amphi-Atlantic. Similarity analyses based on both Bray Curtis and Hellinger distances among 9 faunal collections, and principal component analysis based on presence/absence of megafauna species at these sites, suggest that within the AEB seep megafauna community structure is influenced primarily by depth rather than by geographic distance. Depth segregation is observed between 1000 and 2000 m, with the middle slope sites either grouped with those deeper than 2000 m or with the shallower sites. The highest level of community similarity was found between the seeps of the Florida escarpment and Congo margin. In the western Atlantic, the highest degree of similarity is observed between the shallowest sites of the Barbados prism and of the Louisiana slope. The high number of amphi-atlantic cold-seep species that do not cluster according to biogeographic regions, and the importance of depth in structuring AEB cold-seep communities are the major conclusions of this study. The hydrothermal vent sites along the Mid Atlantic Ridge (MAR did not appear as "stepping stones" for dispersal of the AEB seep fauna, however, the south MAR and off axis regions

  14. The influence of tidal winds in the formation of blanketing sporadic e-layer over equatorial Brazilian region

    Science.gov (United States)

    Resende, Laysa Cristina Araujo; Batista, Inez Staciarini; Denardini, Clezio Marcos; Batista, Paulo Prado; Carrasco, Alexander José; Andrioli, Vânia Fátima; Moro, Juliano

    2018-06-01

    This work analysis the blanketing sporadic layers (Esb) behavior over São Luís, Brazil (2° 31‧ S, 44° 16‧ W, dip: -4.80) which is classified as a transition region between equatorial and low-latitude. Hence, some peculiarities can appear as Esb occurrence instead of the common Esq, which is a non-blanketing irregularity layer. The analysis presented here was obtained using a modified version of a theoretical model for the E region (MIRE), which computes the densities of the metallic ions (Fe+ and Mg+) and the densities of the main molecular ions (NO+, O2+, N2+) by solving the continuity and momentum equations for each one of them. In that model, the Es layer physics driven by both diurnal and semidiurnal tidal winds are taken into account and it was extended in height coverage by adding a novel neutral wind model derived from the all-sky meteor radar measurements. Thus, we provide more trustworthy results related to the Es layer formation in the equatorial region. We verified the contribution of each tidal wind component to the Esb layer formation in this equatorial region. Additionally, we compared the Es layer electron density computed by MIRE with the data obtained by using the blanketing frequency parameter (fbEs) deduced from ionograms. The results show that the diurnal component of the tidal wind is more important in the Esb layer formation whereas the semidiurnal component has a little contribution in our simulations. Finally, it was verified that the modified MIRE presented here can be used to study the Esb layers occurrence over the equatorial region in the Brazilian sector.

  15. Vertical Rise Velocity of Equatorial Plasma Bubbles Estimated from Equatorial Atmosphere Radar Observations and High-Resolution Bubble Model Simulations

    Science.gov (United States)

    Yokoyama, T.; Ajith, K. K.; Yamamoto, M.; Niranjan, K.

    2017-12-01

    Equatorial plasma bubble (EPB) is a well-known phenomenon in the equatorial ionospheric F region. As it causes severe scintillation in the amplitude and phase of radio signals, it is important to understand and forecast the occurrence of EPBs from a space weather point of view. The development of EPBs is presently believed as an evolution of the generalized Rayleigh-Taylor instability. We have already developed a 3D high-resolution bubble (HIRB) model with a grid spacing of as small as 1 km and presented nonlinear growth of EPBs which shows very turbulent internal structures such as bifurcation and pinching. As EPBs have field-aligned structures, the latitude range that is affected by EPBs depends on the apex altitude of EPBs over the dip equator. However, it was not easy to observe the apex altitude and vertical rise velocity of EPBs. Equatorial Atmosphere Radar (EAR) in Indonesia is capable of steering radar beams quickly so that the growth phase of EPBs can be captured clearly. The vertical rise velocities of the EPBs observed around the midnight hours are significantly smaller compared to those observed in postsunset hours. Further, the vertical growth of the EPBs around midnight hours ceases at relatively lower altitudes, whereas the majority of EPBs at postsunset hours found to have grown beyond the maximum detectable altitude of the EAR. The HIRB model with varying background conditions are employed to investigate the possible factors that control the vertical rise velocity and maximum attainable altitudes of EPBs. The estimated rise velocities from EAR observations at both postsunset and midnight hours are, in general, consistent with the nonlinear evolution of EPBs from the HIRB model.

  16. Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress

    Directory of Open Access Journals (Sweden)

    Mykhailo Stepanovych Reheda

    2017-11-01

    Full Text Available We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde and antioxidant (superoxide dismutase, ceruloplasmin, catalase systems in guinea pigs’ lungs  under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs ( control, II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd  day of experiment;IV- group of animals on 34th day of experimental model of IS. The results of our experimental work showed  a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods ( on 1st, 2nd and 34th days of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin. disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.

  17. Preface: The International Reference Ionosphere (IRI) at equatorial latitudes

    Science.gov (United States)

    Reinisch, Bodo; Bilitza, Dieter

    2017-07-01

    This issue of Advances in Space Research includes papers that report and discuss improvements of the International Reference Ionosphere (IRI). IRI is the international standard for the representation of the plasma in Earth's ionosphere and recognized as such by the Committee on Space Research (COSPAR), the International Union of Radio Science (URSI), the International Telecommunication Union (ITU), and the International Standardization Organization (ISO). As requested, particularly by COSPAR and URSI, IRI is an empirical model relying on most of the available and reliable ground and space observations of the ionosphere. As new data become available and as older data sources are fully exploited the IRI model undergoes improvement cycles to stay as close to the existing data record as possible. The latest episode of this process is documented in the papers included in this issue using data from the worldwide network of ionosondes, from a few of the incoherent scatter radars, from the Alouette and ISIS topside sounders, and from the Global Navigation Satellite Systems (GNSS). The focus of this issue is on the equatorial and low latitude region that is of special importance for ionospheric physics because it includes the largest densities and steep density gradients in the double hump latitudinal structure, the Equatorial Ionization Anomaly (EIA), which is characteristic for this region.

  18. The rôle of the complete Coriolis force in cross-equatorial flow of abyssal ocean currents

    Science.gov (United States)

    Stewart, A. L.; Dellar, P. J.

    Ocean currents flowing close to or across the equator are strongly constrained by the change in sign of f, the locally vertical component of the Earth's rotation vector, across the equator. We investigate these currents using a shallow water model that includes both the locally vertical and locally horizontal components of the Earth's rotation vector, thus accounting for the complete Coriolis force. We therefore avoid making the so-called "traditional approximation" that retains only the part of the Coriolis force associated with the locally vertical component of the rotation vector. Including the complete Coriolis force contributes an additional term to the fluid's potential vorticity, which may partially balance the change in sign of f as fluid crosses the equator over suitably shaped bathymetry. We focus on the Antarctic Bottom Water, which crosses the equator northwards in the western Atlantic ocean where the local bathymetry forms an almost-zonal channel. We show that this bathymetry facilitates the current's equatorial crossing via the action of the "non-traditional" component of the Coriolis force. We illustrate this process using both analytical and numerical solutions for flow of an abyssal current over idealised equatorial topography. We also consider the one-dimensional geostrophic adjustment of a body of fluid across the equator, and show that the "non-traditional" contribution to the fluid's angular momentum permits a larger cross-equatorial transport. These results underline the importance of including the complete Coriolis force in studies of the equatorial ocean, particularly in the weakly-stratified abyssal ocean where the non-traditional component is most pronounced.

  19. Pathogenesis of a genotype C strain of bovine parainfluenza virus type 3 infection in albino guinea pigs.

    Science.gov (United States)

    Shi, Hong-Fei; Zhu, Yuan-Mao; Dong, Xiu-Mei; Cai, Hong; Ma, Lei; Wang, Shu; Yan, Hao; Wang, Xue-Zhi; Xue, Fei

    2014-08-08

    Bovine parainfluenza virus type 3 (BPIV3) is one of the most important of the known viral respiratory tract agents of both young and adult cattle and widespread among cattle around the world. Up to present, three genotypes A, B and C of BPIV3 have been described on the basis of genetic and phylogenetic analysis and only limited studies on the pathogenesis of the genotype A of BPIV3 infection in calves and laboratory animals have been performed. The report about experimental infections of the genotypes B and C of BPIV3 in laboratory animals and calves was scant. Therefore, an experimental infection of guinea pigs with the Chinese BPIV3 strain SD0835 of the genotype C was performed. Sixteen guinea pigs were intranasally inoculated with the suspension of SD0835, while eight control guinea pigs were also intranasally inoculated with the same volume of supernatant from uninfected MDBK cells. The virus-inoculated guinea pigs displayed a few observable clinical signs that were related to the respiratory tract disease and two of the sixteen experimentally infected guinea pigs died at 2 and 3 days post inoculation (PI), respectively, and apparent gross pneumonic lesions were observed at necropsy. The gross pneumonic lesions in guinea pigs inoculated with SD0835 consisted of dark red, slightly depressed, irregular areas of consolidation in the lung lobes from the second to 9th day of infection at necropsy, and almost complete consolidation and atelectasis of the lung lobes were seen at 7 days PI. Histopathological changes including alveoli septa thickening and focal cellulose pneumonia were also observed in the lungs of guinea pigs experimentally infected with SD0835. Viral replication was detectable by virus isolation and titration, real-time RT-PCR and immunohistochemistry (IHC) staining in the respiratory tissues of guinea pigs as early as 24h after intranasal inoculation with SD0835. The results of virus isolation and titration showed that guinea pigs were permissive for

  20. Sporadic-E associated with the Leonid meteor shower event of November 1998 over low and equatorial latitudes

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    H. Chandra

    2001-01-01

    Full Text Available Rapid radio soundings were made over Ahmedabad, a low latitude station during the period 16–20 November 1998 to study the sporadic-E layer associated with the Leonid shower activity using the KEL Aerospace digital ionosonde. Hourly ionograms for the period 11 November to 24 November were also examined during the years from 1994 to 1998. A distinct increase in sporadic-E layer occurrence is noticed on 17, 18 and 19 November from 1996 to 1998. The diurnal variations  of  f0Es and fbEs also show significantly enhanced values for the morning hours of 18 and 19 November 1998. The ionograms clearly show strong sporadic-E reflections at times of peak shower activity with multiple traces in the altitude range of 100–140 km in few ionograms. Sporadic-E layers with multiple structures in altitude are also seen in some of the ionograms (quarter hourly at Thumba, situated near the magnetic equator. Few of ionograms recorded at Kodaikanal, another equatorial station, also show sporadic- E reflections in spite of the transmitter power being significantly lower. These new results highlighting the effect of intense meteor showers in the equatorial and low latitude E-region are presented.Key words. Ionosphere (equatorial ionosphere – Radio science (ionospheric physics

  1. Sporadic-E associated with the Leonid meteor shower event of November 1998 over low and equatorial latitudes

    Directory of Open Access Journals (Sweden)

    H. Chandra

    Full Text Available Rapid radio soundings were made over Ahmedabad, a low latitude station during the period 16–20 November 1998 to study the sporadic-E layer associated with the Leonid shower activity using the KEL Aerospace digital ionosonde. Hourly ionograms for the period 11 November to 24 November were also examined during the years from 1994 to 1998. A distinct increase in sporadic-E layer occurrence is noticed on 17, 18 and 19 November from 1996 to 1998. The diurnal variations 
    of  f0Es and fbEs also show significantly enhanced values for the morning hours of 18 and 19 November 1998. The ionograms clearly show strong sporadic-E reflections at times of peak shower activity with multiple traces in the altitude range of 100–140 km in few ionograms. Sporadic-E layers with multiple structures in altitude are also seen in some of the ionograms (quarter hourly at Thumba, situated near the magnetic equator. Few of ionograms recorded at Kodaikanal, another equatorial station, also show sporadic- E reflections in spite of the transmitter power being significantly lower. These new results highlighting the effect of intense meteor showers in the equatorial and low latitude E-region are presented.

    Key words. Ionosphere (equatorial ionosphere – Radio science (ionospheric physics

  2. Dynamical diagnostics of the SST annual cycle in the eastern equatorial Pacific: part I a linear coupled framework

    Science.gov (United States)

    Chen, Ying-Ying; Jin, Fei-Fei

    2018-03-01

    The eastern equatorial Pacific has a pronounced westward propagating SST annual cycle resulting from ocean-atmosphere interactions with equatorial semiannual solar forcing and off-equatorial annual solar forcing conveyed to the equator. In this two-part paper, a simple linear coupled framework is proposed to quantify the internal dynamics and external forcing for a better understanding of the linear part of the dynamics annual cycle. It is shown that an essential internal dynamical factor is the SST damping rate which measures the coupled stability in a similar way as the Bjerknes instability index for the El Niño-Southern Oscillation. It comprises three major negative terms (dynamic damping due to the Ekman pumping feedback, mean circulation advection, and thermodynamic feedback) and two positive terms (thermocline feedback and zonal advection). Another dynamical factor is the westward-propagation speed that is mainly determined by the thermodynamic feedback, the Ekman pumping feedback, and the mean circulation. The external forcing is measured by the annual and semiannual forcing factors. These linear internal and external factors, which can be estimated from data, determine the amplitude of the annual cycle.

  3. Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs

    International Nuclear Information System (INIS)

    Olson, J.R.

    1986-01-01

    Marked interspecies variability exists in the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), with the guinea pig being the mammalian species most sensitive to the acute toxicity of TCDD. The metabolism and disposition of TCDD was investigated in guinea pigs for 45 days following a single exposure to purified [ 3 H]TCDD (0.56 microgram/kg, ip). Guinea pigs included in the toxicokinetic study gained body weight, maintained a normal relative body composition, and exhibited no gross signs of toxicity during the 45-day study. Approximately 36% of the dose of TCDD-derived 3 H remained in the adipose tissue at 45 days following exposure to [ 3 H]TCDD, while the liver, pelt, and skeletal muscle and carcass each contained about 7% of the administered dose. Although most of the TCDD-derived radioactivity in liver, kidney, perirenal adipose tissue, and skeletal muscle represented unchanged TCDD, from 4 to 28% of the 3 H was associated with metabolites of TCDD. This unexpected finding suggests that TCDD metabolites are not efficiently excreted from guinea pigs. The urinary and fecal excretion of TCDD-derived radioactivity followed apparent first-order kinetics, with an elimination half-life of 93.7 +/- 15.5 days (mean +/- SD). HPLC analysis of urine and bile from [ 3 H]TCDD-treated guinea pigs showed that all of the radioactivity represented metabolites of TCDD, indicating that these routes of elimination are dependent on prior metabolism of TCDD. However, 70 to 90% of the radioactivity in fecal samples was found to represent unmetabolized TCDD throughout the 45-day excretion study. The presence of TCDD in feces and its absence in bile suggest that the fecal excretion of unchanged TCDD resulted from the direct intestinal elimination of the lipophilic toxin

  4. Antagonist profile of ibodutant at the tachykinin NK2 receptor in guinea pig isolated bronchi.

    Science.gov (United States)

    Santicioli, Paolo; Meini, Stefania; Giuliani, Sandro; Lecci, Alessandro; Maggi, Carlo Alberto

    2013-10-24

    In this study we have characterized the pharmacological profile of the non-peptide tachykinin NK 2 receptor antagonist ibodutant (MEN15596) in guinea pig isolated main bronchi contractility. The antagonist potency of ibodutant was evaluated using the selective NK 2 receptor agonist [βAla 8 ]NKA(4-10)-mediated contractions of guinea pig isolated main bronchi. In this assay ibodutant (30, 100 and 300nM) induced a concentration-dependent rightward shift of the [βAla 8 ]NKA(4-10) concentration-response curves without affecting the maximal contractile effect. The analysis of the results yielded a Schild-plot linear regression with a slope not different from unity (0.95, 95% c.l. 0.65-1.25), thus indicating a surmountable behaviour. The calculated apparent antagonist potency as pK B value was 8.31±0.05. Ibodutant (0.3-100nM), produced a concentration-dependent inhibition of the nonadrenergic-noncholinergic (NANC) contractile response induced by electrical field stimulation (EFS) of intrinsic airway nerves in guinea pig isolated main bronchi. At the highest concentration tested (100nM) ibodutant almost abolished the EFS-induced bronchoconstriction (95±4% inhibition), the calculated IC 50 value was 2.98nM (95% c.l. 1.73-5.16nM). In bronchi from ovalbumin (OVA) sensitized guinea pigs ibodutant (100nM) did not affect the maximal contractile response to OVA, but completely prevented the slowing in the fading of the motor response induced by phosphoramidon pretreatment linked to the endogenous neurokinin A release. Altogether, the present study demonstrate that ibodutant is a potent NK 2 receptor antagonist in guinea pig airways. © 2013 Published by Elsevier B.V.

  5. Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic.

    Science.gov (United States)

    Simon-Loriere, Etienne; Faye, Ousmane; Faye, Oumar; Koivogui, Lamine; Magassouba, Nfaly; Keita, Sakoba; Thiberge, Jean-Michel; Diancourt, Laure; Bouchier, Christiane; Vandenbogaert, Matthias; Caro, Valérie; Fall, Gamou; Buchmann, Jan P; Matranga, Christan B; Sabeti, Pardis C; Manuguerra, Jean-Claude; Holmes, Edward C; Sall, Amadou A

    2015-08-06

    An epidemic of Ebola virus disease of unprecedented scale has been ongoing for more than a year in West Africa. As of 29 April 2015, there have been 26,277 reported total cases (of which 14,895 have been laboratory confirmed) resulting in 10,899 deaths. The source of the outbreak was traced to the prefecture of Guéckédou in the forested region of southeastern Guinea. The virus later spread to the capital, Conakry, and to the neighbouring countries of Sierra Leone, Liberia, Nigeria, Senegal and Mali. In March 2014, when the first cases were detected in Conakry, the Institut Pasteur of Dakar, Senegal, deployed a mobile laboratory in Donka hospital to provide diagnostic services to the greater Conakry urban area and other regions of Guinea. Through this process we sampled 85 Ebola viruses (EBOV) from patients infected from July to November 2014, and report their full genome sequences here. Phylogenetic analysis reveals the sustained transmission of three distinct viral lineages co-circulating in Guinea, including the urban setting of Conakry and its surroundings. One lineage is unique to Guinea and closely related to the earliest sampled viruses of the epidemic. A second lineage contains viruses probably reintroduced from neighbouring Sierra Leone on multiple occasions, while a third lineage later spread from Guinea to Mali. Each lineage is defined by multiple mutations, including non-synonymous changes in the virion protein 35 (VP35), glycoprotein (GP) and RNA-dependent RNA polymerase (L) proteins. The viral GP is characterized by a glycosylation site modification and mutations in the mucin-like domain that could modify the outer shape of the virion. These data illustrate the ongoing ability of EBOV to develop lineage-specific and potentially phenotypically important variation.

  6. Morphometrical Study of the Temporal Bone and Auditory Ossicles in Guinea Pig

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    Ahmadali Mohammadpour

    2011-03-01

    Full Text Available In this research, anatomical descriptions of the structure of the temporal bone and auditory ossicles have been performed based on dissection of ten guinea pigs. The results showed that, in guinea pig temporal bone was similar to other animals and had three parts; squamous, tympanic and petrous .The tympanic part was much better developed and consisted of oval shaped tympanic bulla with many recesses in tympanic cavity. The auditory ossicles of guinea pig concluded of three small bones; malleus, incus and stapes but the head of the malleus and the body of incus were fused and forming a malleoincudal complex. The average of morphometric parameters showed that the malleus was 3.53 ± 0.22 mm in total length. In addition to head and handle, the malleus had two distinct process; lateral and muscular. The incus had a total length 1.23 ± 0.02mm. It had long and short crus although the long crus was developed better than short crus. The lenticular bone was a round bone that articulated with the long crus of incus. The stapes had a total length 1.38 ± 0.04mm. The anterior crus(0.86 ± 0.08mm was larger than posterior crus (0.76 ± 0.08mm. It is concluded that, in the guinea pig, the malleus and the incus are fused, forming a junction called incus-malleus, while in the other animals these are separate bones. The stapes is larger and has a triangular shape and the anterior and posterior crus are thicker than other rodents. Therefore, for otological studies, the guinea pig is a good lab animal.

  7. Generation and characterization of induced pluripotent stem cells from guinea pig fetal fibroblasts

    Science.gov (United States)

    Wu, Yuehong; Li, Ouyang; He, Chengwen; Li, Yong; Li, Min; Liu, Xiaoming; Wang, Yujiong; He, Yulong

    2017-01-01

    Induced pluripotent stem cells (iPS) represent an important tool to develop disease-modeling assays, drug testing assays and cell-based replacement therapies. The application of iPS in these fields requires the development of suitable animal models. Of the suitable species, guinea pigs are particularly important and offer significant advantages. Successful iPS generation has been accomplished in a number of species; however, it has not been reported in the guinea pig. The present study successfully generated iPS from guinea pigs (giPS) using single polycistronic virus transduction with mouse octamer-binding transcription factor 4 (Oct4), sex determining region Y-box 2 (Sox2), Kruppel-like factor 4 and c-Myc. The giPS cell lines were cultured in media containing leukemia inhibitory factor and guinea pig fibroblast cells were used as feeder cells. These cultures were expanded under feeder-free culture conditions using ESGRO Complete Plus Clonal Grade medium containing 15% fetal bovine serum on gelatin-coated dishes. The resultant cells had a normal karyotype, exhibited alkaline phosphatase activity and expressed the pluripotency markers Oct4, Sox2 and Nanog. The cells differentiated in vivo to form teratomas that contained all three germ layers of the tissue cells. The generation of giPS may facilitate future studies investigating the mechanisms underlying innate immunity, particularly for tuberculosis. These experiments provide proof of principle that iPS technology may be adapted to use the guinea pig as a model of human diseases. PMID:28393187

  8. Developmental expression of Toll‑like receptors in the guinea pig lung.

    Science.gov (United States)

    Ma, Lingjie; Yang, Jiali; Yang, Li; Shi, Juan; Xue, Jing; Li, Yong; Liu, Xiaoming

    2017-03-01

    The guinea pig is a useful model for investigating infectious and non‑infectious lung diseases due to the sensitivity of its respiratory system and susceptibility to infectious agents. Toll‑like receptors (TLRs) are important components of the innate immune response and are critical for lung immune function. In the present study, the differentiation of epithelial cells in the guinea pig lung was examined during gestation by studying anatomic morphology and the major epithelial cell types using cell type‑specific markers. The developmental expression of all 9 TLRs and the TLR signaling adaptors myeloid differentiation factor 88 (MyD88) and tumor necrosis factor receptor associated factor 6 (TRAF‑6) were investigated by reverse transcription‑quantitative polymerase chain reaction and western blotting analysis. The formation of lung lobes in guinea pigs was observed at 45 days of gestation (dGA), along with the expression of the basal cell marker keratin 14 and the alveolar type II cell marker pro‑surfactant protein. However, the cube cell marker secretoglobin family1A member 1 and ciliated cell marker b‑tubulin IV were only detected in the lungs from 52 dGA onward. The expression levels of all TLRs, MyD88 and TRAF‑6 were determined in lung tissues harvested from embryos, newborn, postnatal and adult animals. The expression levels of all TLR signaling components displayed similar dynamic expression patterns with gestation age and postnatal maturation time, except for TLR‑4 and TLR‑7. mRNA expression levels of TLR components were significantly increased in the lungs at 45 and 52 dGA, compared with later developmental stages. These results suggest that TLR expression in the guinea pig lung is developmentally regulated, enhancing the understanding of lung biology in guinea pig models.

  9. Generation and characterization of induced pluripotent stem cells from guinea pig fetal fibroblasts.

    Science.gov (United States)

    Wu, Yuehong; Li, Ouyang; He, Chengwen; Li, Yong; Li, Min; Liu, Xiaoming Liu; Wang, Yujiong; He, Yulong

    2017-06-01

    Induced pluripotent stem cells (iPS) represent an important tool to develop disease‑modeling assays, drug testing assays and cell‑based replacement therapies. The application of iPS in these fields requires the development of suitable animal models. Of the suitable species, guinea pigs are particularly important and offer significant advantages. Successful iPS generation has been accomplished in a number of species; however, it has not been reported in the guinea pig. The present study successfully generated iPS from guinea pigs (giPS) using single polycistronic virus transduction with mouse octamer‑binding transcription factor 4 (Oct4), sex determining region Y‑box 2 (Sox2), Kruppel‑like factor 4 and c‑Myc. The giPS cell lines were cultured in media containing leukemia inhibitory factor and guinea pig fibroblast cells were used as feeder cells. These cultures were expanded under feeder‑free culture conditions using ESGRO Complete Plus Clonal Grade medium containing 15% fetal bovine serum on gelatin‑coated dishes. The resultant cells had a normal karyotype, exhibited alkaline phosphatase activity and expressed the pluripotency markers Oct4, Sox2 and Nanog. The cells differentiated in vivo to form teratomas that contained all three germ layers of the tissue cells. The generation of giPS may facilitate future studies investigating the mechanisms underlying innate immunity, particularly for tuberculosis. These experiments provide proof of principle that iPS technology may be adapted to use the guinea pig as a model of human diseases.

  10. An annotated ornithological bibliography of Guinea-Bissau

    NARCIS (Netherlands)

    Hazevoet, C.J.

    1995-01-01

    Guinea-Bissau, a former Portuguese colony, is a small country (36,125 km²) in West Africa bordered by Senegal in the north and Guinea (Conakry) in the east and south. Little is known about the country’s ornithology and comparatively few papers on its birds have been published. The following is an

  11. CHARACTERIZATION OF MUSCARINIC RECEPTORS IN GUINEA-PIG UTERUS

    NARCIS (Netherlands)

    DOODS, HN; WILLIM, KD; BODDEKE, HWGM; ENTZEROTH, M

    1993-01-01

    To characterize the muscarinic receptor present in guinea-pig uterus smooth muscle the affinities of a series of 27 muscarinic receptor antagonists for M1 (rat cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (transfected in CHO cells) and muscarinic binding sites in guinea-pig uterus

  12. Heterogeneous infectiousness in guinea pigs experimentally infected with Trypanosoma cruzi.

    Science.gov (United States)

    Castillo-Neyra, Ricardo; Borrini Mayorí, Katty; Salazar Sánchez, Renzo; Ancca Suarez, Jenny; Xie, Sherrie; Náquira Velarde, Cesar; Levy, Michael Z

    2016-02-01

    Guinea pigs are important reservoirs of Trypanosoma cruzi, the causative parasite of Chagas disease, and in the Southern Cone of South America, transmission is mediated mainly by the vector Triatoma infestans. Interestingly, colonies of Triatoma infestans captured from guinea pig corrals sporadically have infection prevalence rates above 80%. Such high values are not consistent with the relatively short 7-8 week parasitemic period that has been reported for guinea pigs in the literature. We experimentally measured the infectious periods of a group of T. cruzi-infected guinea pigs by performing xenodiagnosis and direct microscopy each week for one year. Another group of infected guinea pigs received only direct microscopy to control for the effect that inoculation by triatomine saliva may have on parasitemia in the host. We observed infectious periods longer than those previously reported in a number of guinea pigs from both the xenodiagnosis and control groups. While some guinea pigs were infectious for a short time, other "super-shedders" were parasitemic up to 22 weeks after infection, and/or positive by xenodiagnosis for a year after infection. This heterogeneity in infectiousness has strong implications for T. cruzi transmission dynamics and control, as super-shedder guinea pigs may play a disproportionate role in pathogen spread. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  13. Epidemiological evidence of listeriosis in guinea pigs fed with ...

    African Journals Online (AJOL)

    Listeria monocytogenes is a bacterium that infects livestock and humans. We report the first outbreak of invasive listeriosis caused by L. monocytogenes in a guinea pig breeding colony. Eighty to 100% mortality rate was recorded in the colony of 80 guinea pigs within four weeks outbreak. On epidemiologic investigation ...

  14. Quality Attributes Of Two Species Of Indigenous Guinea Fowl Meat ...

    African Journals Online (AJOL)

    As the duration of storage of the guinea fowl meats increased percentage of weight loss, cooking loss, pH, and tenderness scores increased (P < 0.05). Prepackaging or salting of guinea fowl meats reduced (P< 0.05) percentages of weight loss, cooking loss and increased (P < 0.05) pH, water holding Capacity and sensory ...

  15. Piper (Piperaceae) in New Guinea: the climbing species

    NARCIS (Netherlands)

    Gardner, R.O.

    2012-01-01

    Sixteen climbing Piper species are accepted for New Guinea. The three endemics, P. arfakianum, P. subcanirameum and P. versteegii, are fully described. Eight taxa of unclear circumscription are noted. A new variety of P. macropiper, endemic to Morobe Province of Papua New Guinea, is described. The

  16. Transplacental absorption of 238Pu in rats and guinea pigs

    International Nuclear Information System (INIS)

    Sullivan, M.F.

    1980-01-01

    Pregnant rats and guinea pigs were injected intravenously with 238 Pu citrate to determine if the potential for in utero accumulation of 238 Pu by these two species is related to the stage of development at which immunity is gained. Although guinea pigs retained more 238 Pu after birth than rats, the difference was not significant

  17. Crossed Looks: Globalisations and Curriculum in Guinea-Bissau

    Science.gov (United States)

    da Silva, Rui; dos Santos, Júlio Gonçalves; Pacheco, José Augusto

    2015-01-01

    This article focuses on education in Guinea-Bissau in the context of globalisations, examining the concept of globalisation and its relation to education and the curriculum. It focuses on the relatively neglected area of national education policies in Guinea-Bissau, comparing differences and common points of interference/influence of multilateral…

  18. Briti eliit üritas kukutada Ekvatoriaal-Guinea valitsust

    Index Scriptorium Estoniae

    2004-01-01

    Ekvatoriaal-Guineas ja Zimbabwes on vahistatud kümneid inimesi, keda süüdistatakse riigipöördekatses Ekvatoriaal-Guineas. Suurbritannia endise peaministri Margaret Thatcher'i poega Mark Thatcher'it süüdistatakse riigipöördekatse rahastamisele kaasaaitamises

  19. A 2-D guinea pig lung proteome map

    Science.gov (United States)

    Guinea pigs represent an important model for a number of infectious and non-infectious pulmonary diseases. The guinea pig genome has recently been sequenced to full coverage, opening up new research avenues using genomics, transcriptomics and proteomics techniques in this species. In order to furth...

  20. RELATIONSHIP BETWEEN BEHAVIORAL AND AUTONOMIC THERMOREGULATION IN THE GUINEA PIG

    Science.gov (United States)

    The study was conducted to correlate the preferred thermal environment of the unrestrained guinea pig with the activity of its thermoregulatory effectors when maintained under a wide range of ambient temperatures (Ta). Eight male guinea pigs were used in a series of experiments o...

  1. The Guinea Pigs of a Problem-Based Learning Curriculum

    Science.gov (United States)

    Reddy, Sarasvathie; McKenna, Sioux

    2016-01-01

    Participants in a study on learning the clinical aspects of medicine in a problem-based learning (PBL) curriculum repeatedly referred to themselves as "Guinea pigs" at the mercy of a curriculum experiment. This article interrogates and problematises the "Guinea pig" identity ascribed to and assumed by the first cohort of…

  2. An Analysis Of Guinea Worm Infection On Yam Productivity In ...

    African Journals Online (AJOL)

    Guinea worm infection has been reported to be one of the external diseconomies factors that limit agricultural productivity of the rural farm households. The study examined the determinants of farmers' vulnerability to guineaworm infection and the effect of guinea worm infection on yam yield in the study area. A stratified ...

  3. Confinement lowers fertility rate of helmeted guinea fowl ( Numida ...

    African Journals Online (AJOL)

    ... common game bird in Africa and there have been efforts to domesticate it for use as a source of human food. An important obstacle in successful domestication of guinea fowl is their low fertility rate.We studied the effects of semi-confinement on the fertility rates of helmeted guinea fowl by comparing egg fertility, hatch rate ...

  4. Extraction and application of dyestuffs from the leaves of guinea ...

    African Journals Online (AJOL)

    This research work is aimed at assessing the dyeing and colouring potentials of ethanol extracts from the leaves of guinea corn and the skin of onion. It is intended to apply the purified dye extracts on textile, drink and food. The leaves of guinea corn (Sorghum bicolor) and the skin of onion (Allium cepa) were collected, ...

  5. First records in Guinea Bissau of Adamawa Turtle Dove Streptopelia ...

    African Journals Online (AJOL)

    There are no confirmed records of the Adamawa Turtle Dove Streptopelia hypopyrrha in north-eastern Guinea Bissau and there is very little information available on the biology of the species. Eight individuals of the Adamawa Turtle Dove were identified from the game bags of sport hunters in north-eastern Guinea Bissau, ...

  6. PLUMEX II: A second set of coincident radar and rocket observations of equatorial spread-F

    International Nuclear Information System (INIS)

    Szuszczewicz, E.P.; Tsunoda, R.T.; Narcisi, R.; Holmes, J.C.

    1981-01-01

    PLUMEX II, the second rocket in a two-rocket operation that successfully executed coincident rocket and radar measurements of backscatter plumes and plasma depletions, was launched into the mid-phase of well-developed equatorial spread-F. In contrast with the first operation, the PLUMEX II results show large scale F-region irregularities only on the bottomside gradient with smaller scale irregularities (i.e., small scale structure imbedded in larger scale features) less intense than corresponding observations in PLUMEX I. The latter result could support current interpretations of east-west plume asymmetry which suggests that during initial upwelling the western wall of a plume (the PLUMEX I case) is more unstable than its eastern counterpart (the PLUMEX II case). In addition, ion mass spectrometer results are found to provide further support for an ion transport model which ''captures'' bottomside ions in an upwelling bubble and transports them to high altitudes

  7. Transmission of Influenza B Viruses in the Guinea Pig

    Science.gov (United States)

    Pica, Natalie; Chou, Yi-Ying; Bouvier, Nicole M.

    2012-01-01

    Epidemic influenza is typically caused by infection with viruses of the A and B types and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses can replicate in the upper respiratory tract of the guinea pig and that viruses of the two main lineages can be transmitted with 100% efficiency between inoculated and naïve animals in both contact and noncontact models. Our results also indicate that, like in the case for influenza A virus, transmission of influenza B viruses is enhanced at colder temperatures, providing an explanation for the seasonality of influenza epidemics in temperate climates. We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission. PMID:22301149

  8. Comparison of hepatotoxicity and metabolism of butyltin compounds in the liver of mice, rats and guinea pigs

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Shunji; Kashimoto, Takashige; Susa, Nobuyuki; Ishii, Masamitsu; Chiba, Toshikazu [Laboratory of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, 034-8628, Towada-shi, Aomori (Japan); Mutoh, Ken-ichiro [Laboratory of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, 034-8628, Towada-shi, Aomori (Japan); School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, 034-8628, Towada-shi, Aomori (Japan); Hoshi, Fumio [Laboratory of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato University, Higashi 23-35-1, 034-8628, Towada-shi, Aomori (Japan); Suzuki, Takashi [Laboratory of Environmental Health and Toxicology, Kyoto Prefectural University, Hangi-cho, Shimogamo, Sakyo-ku, 606-5822, Kyoto (Japan); Sugiyama, Masayasu [Sugiyama Pharmacy, 1335-1 Shimotama, Tamagawa-cho, 759-3112, Yamaguchi (Japan)

    2003-03-01

    the liver at 3 h after the administration showed that the levels of DBTC in the nuclear, microsomal and mitochondrial fractions of mice hepatocytes were relatively higher than in those of rats, which were greater than in those of guinea pigs. These results suggest differences in the sensitivity of mice, rats and guinea pigs to hepatotoxicity caused by butyltin compounds and demonstrate that the difference in the sensitivity of these animals to the hepatotoxicity induced by TBTC and DBTC may be partly due to differences in hepatic metabolism of TBTC and in the distribution of DBTC within cell organelles, respectively. (orig.)

  9. Gastric volvulus in guinea pigs: comparison with other species.

    Science.gov (United States)

    Dudley, Emily S; Boivin, Gregory P

    2011-07-01

    Gastric volvulus has been documented in several species of animals and is associated with high morbidity and mortality. We report 2 cases of gastric volvulus in guinea pigs that died without detection of prior clinical signs. Both guinea pigs were adult female guinea pigs in a breeding colony and had given birth to multiple litters; one was pregnant at the time of death. Gastric rotations of 540° and 360° were identified at necropsy examination. These cases include the first known report of gastric rotation greater than 360° in any species. Although gastric volvulus has been reported to occur in guinea pigs, little is known about its risk factors, etiology, and pathogenesis. We conducted a literature review to compare gastric volvulus between guinea pigs and other species. Copyright 2011 by the American Association for Laboratory Animal Science

  10. Variability in the origins and pathways of Pacific Equatorial Undercurrent water

    NARCIS (Netherlands)

    Qin, Xuerong; Sen Gupta, Alex; Van Sebille, Erik

    2015-01-01

    The Pacific Equatorial Undercurrent (EUC) transports water originating from a number of distinct source regions, eastward across the Pacific Ocean. It is responsible for supplying nutrients to the productive eastern Equatorial Pacific Ocean. Of particular importance is the transport of iron by the

  11. Influence of biomass burning emissions on precipitation chemistry in the equatorial forests of Africa

    International Nuclear Information System (INIS)

    Lacaux, J.P.; Lefeivre, B.; Delmas, R.A.; Cros, B.; Andreae, M.O.

    1991-01-01

    As part of the DESCAFE program (Dynamics and Chemistry of the Atmosphere in Equatorial Forest), measurements of precipitation chemistry were made at two sampling sites of the equatorial forest in the Republic of Congo. The measurements were made in order to identify and compare atmospheric sources of gases and particles (mainly biogenic sources and emissions from burning vegetation)

  12. Aristotle, alive and well in Papua New Guinea science classrooms

    Science.gov (United States)

    Boeha, Beno B.

    1990-09-01

    National High School students from Papua New Guinea were interviewed about two situations; the results of their Aristotle-like views regarding `forced' and `natural' motion are presented and discussed. Twenty-one National High School Students were interviewed about two situations similarly used elsewhere (Osborne and Gibert 1979, 1980, Osborne 1980a) and the results of these Aristotle-like views possessed by students have been presented and discussed above. With each of the six summary statements some extracts have been provided from interviews conducted by the author with students who had come from various parts of Pupua New Guinea. Students' views have been compiled to give a composite picture of the Aristotle-like ideas. Some impression of the commonality of the ideas/beliefs has been provided by reference to the work of others who have reported similar tendencies in testing and interviewing physics students. Throughout the study, students' Aristotlean-like views have been given a respected status that reflects their widespread use, their internal coherence and their tenacity in the face of classroom teaching in a Pupua New Guinea National High School. In analysing individual interview transcripits, attempts were made to construct ideas/beliefs that can account for statements by each student in a manner that statements are consistent with each other. The assumption that all of a student's statements are logically compatible to a listener or reader is difficult to maintain. However, it is one that has to be made as a hypothesis to work with, otherwise it is too easy to discount sections of a student's discourse that seem inconsistent with understandable parts. The aims of this part of the study have been to provide science educationalists with a repertoire of common Aristolean-like beliefs which have persisted in students. These views differ in some ways from the orthodox physics views. By better understanding of the students' beliefs and commitments about

  13. Quasi-biennial variation of equatorial waves as seen in satellite remote sensing data

    Science.gov (United States)

    Chen, Zeyu

    The quasi-biennial oscillation (QBO) in zonal winds in the lower stratosphere at the Equator is the most prominent inter-annual variation signal in the middle atmosphere. Theoretically, it is driven by the drag from the damping of equatorial waves including the equatorially trapped planetary scale waves, such as Kelvin waves propagating eastward and Rossby-gravity waves propagating westward, inertio-gravity waves and gravity waves. In current research, the tem-perature data collected by the SABER/TIMED mission in 2002-2009 are used to investigate the equatorial waves activities. The Fast Fourier Synoptic Mapping (FFSM) method is applied to delineate planetary wave components with the zonal wavenumber spanning over -6 to +6, hereby, positive (negative) wavenumber is assigned to westward (eastward) propagating waves. Limited by the SABER/TIMED sampling scheme, only the waves with periods longer than one day can be resolved. Focusing on the height region 70-10 hPa where the QBO signal is most significant, it is clearly observed that the composite activity of all the eastward waves exhibit QBO like variation. Specifically, for each QBO cycle, the activity at 50 hPa level is characterized by the occurrence of a substantially clear minimum that coincides to the fast downward propagation of the westerly phase, the typical pattern of the QBO phenomenon. Phase speed spectra are derived by using the FFSM analysis results. And vertical shear of the zonal wind is derived by using the rawinsonde data at Singapore. Comparison of the phase speed spectra and the wind shear indicates that the minimum is due to the westerly shear below 30 hPa. Between the minimum, significant wave activities emerge, thus the property for the components are investigated. Results show that in height range 70-10 hPa, both wave 1 to wave 3 are prominent during the inter-minimum period for each QBO cycle. At 50 hPa level, wave 1 component exhibits amplitude spectral peak at three kinds of period, 8, 11

  14. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

    Science.gov (United States)

    Ramamoorthy, Sripriya; Zhang, Yuan; Petrie, Tracy; Fridberger, Anders; Ren, Tianying; Wang, Ruikang; Jacques, Steven L.; Nuttall, Alfred L.

    2015-02-01

    In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 - 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.

  15. Pharmacokinetics of activated protein C in guinea pigs

    International Nuclear Information System (INIS)

    Berger, H. Jr.; Kirstein, C.G.; Orthner, C.L.

    1991-01-01

    Protein C is a vitamin K-dependent zymogen of the serine protease, activated protein C (APC), an important regulatory enzyme in hemostasis. In view of the potential of human APC as an anticoagulant and profibrinolytic agent, the pharmacokinetics and tissue distribution of APC were studied in guinea pigs. The plasma elimination of a trace dose of 125 I-APC was biphasic following an initial rapid elimination of approximately 15% of the injected dose within 1 to 2 minutes. This rapid removal of 125 I-APC from the circulation was found to be a result of an association with the liver regardless of the route of injection. Essentially identical results were obtained with active site-blocked forms of APC generated with either diisopropylfluorophosphate or D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, which indicates that the active site was not essential for the liver association. Accumulation of all three forms of APC in the liver peaked at 30 minutes and then declined as increasing amounts of degraded radiolabeled material appeared in the gastrointestinal tract and urine. Removal of the gamma-carboxyglutamic acid (gla) domain of diisopropylphosphoryl-APC resulted in a 50% reduction in the association with liver and an accumulation in the kidneys. Protein C and protein S were cleared from the circulation at rates approximately one-half and one-fourth, respectively, that of APC. Both in vitro and in vivo, APC was found to form complexes with protease inhibitors present in guinea pig plasma. Complex formation resulted in a more rapid disappearance of the enzymatic activity of APC than elimination of the protein moiety. These findings indicate two distinct mechanisms for the elimination of APC. One mechanism involves reaction with plasma protease inhibitors and subsequent elimination by specific hepatic receptors. (Abstract Truncated)

  16. Unilateral flank ovariohysterectomy in guinea pigs (Cavia porcellus).

    Science.gov (United States)

    Rozanska, D; Rozanski, P; Orzelski, M; Chlebicka, N; Putowska, K

    2016-11-01

    To describe a simple, minimally invasive method of ovariohysterectomy via a unilateral flank approach in guinea pigs, for use in routine desexing of healthy female guinea pigs or treatment of ovarian cysts. The subjects of this retrospective study were 41 client-owned guinea pigs submitted for routine desexing or treatment of ovarian cysts. They included 16 healthy female guinea pigs aged 8-12 months (Group 1), and 15 females aged from 9 months to 3 years (Group 2), and 10 females aged from 3 to 7 years (Group 3) with different-sized ovarian cysts. Prior to surgery, the animals received clinical examination, blood testing (complete blood count and serum biochemistry profile) and examination of the abdomen using ultrasonography, to assess the condition of the reproductive tract and ensure the guinea pigs were fit for surgery. Ovariohysterectomy was performed via a unilateral flank incision made close to the erector spinae muscle starting approximately 1 cm caudal to the last rib. Both ovaries, uterine horns, and the uterine cervix were localised, ligated, and dissected through this unilateral retroperitoneal incision. Ovariohysterectomy was successfully completed via a single flank incision in 38/41 (93%) guinea pigs. Three guinea pigs with ovarian cysts from Group 3, which were >6 years old died during surgery due to circulatory and respiratory failure under anaesthesia. In the remaining 38 cases, surgery proceeded without complications. A further two guinea pigs from Group 3 were reluctant to move or eat for the first 3 days after surgery but recovered after provision of supportive care. All 38 animals fully recovered and wound healing was normal. This is the first report of ovariohysterectomy via a unilateral flank incision in guinea pigs. This approach is a simple, minimally invasive and safe alternative to the midline or bilateral flank approaches currently used for surgery of the reproductive tract in guinea pigs.

  17. Magnetization modeling in the north and equatorial Atlantic Ocean using MAGSAT data

    Science.gov (United States)

    Hayling, K. L.; Harrison, C. G. A.

    1986-01-01

    Magsat 2 x 2-deg scalar anomalous-magnetic-field data (Langel et al., 1982) for the northern and equatorial Atlantic are inverted and combined with physiographic data and laboratory results on the magnetization of oceanic rocks and the oceanic crust to construct models explaining the shorter-wavelength component of the anomalies. An annihilator is applied to the inversion results to eliminate reverse-magnetized sources and facilitate comparisons of areas inverted separately, and a latitude effect on source spacing is tentatively attributed to greater noise contamination at lower latitudes. It is found that remanent magnetization combined with considerable crustal thickening can best explain the high intensity levels observed, although viscous magnetization or contamination of the data by noncrustal sources must also be considered.

  18. Spread F – an old equatorial aeronomy problem finally resolved?

    Directory of Open Access Journals (Sweden)

    R. F. Woodman

    2009-05-01

    Full Text Available One of the oldest scientific topics in Equatorial Aeronomy is related to Spread-F. It includes all our efforts to understand the physical mechanisms responsible for the existence of ionospheric F-region irregularities, the spread of the traces in a night-time equatorial ionogram – hence its name – and all other manifestations of the same. It was observed for the first time as an abnormal ionogram in Huancayo, about 70 years ago. But only recently are we coming to understand the physical mechanisms responsible for its occurrence and its capricious day to day variability. Several additional techniques have been used to reveal the spatial and temporal characteristics of the F-region irregularities responsible for the phenomenon. Among them we have, in chronological order, radio star scintillations, trans-equatorial radio propagation, satellite scintillations, radar backscatter, satellite and rocket in situ measurements, airglow, total electron content techniques using the propagation of satellite radio signals and, recently, radar imaging techniques. Theoretical efforts are as old as the observations. Nevertheless, 32 years after their discovery, Jicamarca radar observations showed that none of the theories that had been put forward could explain them completely. The observations showed that irregularities were detected at altitudes that were stable according to the mechanisms proposed. A breakthrough came a few years later, again from Jicamarca, by showing that some of the "stable" regions had become unstable by the non-linear propagation of the irregularities from the unstable to the stable region of the ionosphere in the form of bubbles of low density plasma. A problem remained, however; the primary instability mechanism proposed, an extended (generalized Rayleigh-Taylor instability, was too slow to explain the rapid development seen by the observations. Gravity waves in the neutral background have been proposed as a seeding mechanism to

  19. Leukotriene B4 receptors on guinea pig alveolar eosinophils

    International Nuclear Information System (INIS)

    Maghni, K.; de Brum-Fernandes, A.J.; Foeldes-Filep, E.G.; Gaudry, M.; Borgeat, P.; Sirois, P.

    1991-01-01

    The existence of receptors for LTB4 on highly purified guinea pig alveolar eosinophils was investigated. Massive infiltration of eosinophils in alveolar spaces was induced in guinea pigs by i.v. injections of Sephadex beads G50 (16 mg/kg). Alveolar eosinophils (50 x 10(6) cells) were purified to approximately 98% by Percoll continuous density gradient centrifugation. The binding studies indicated that alveolar eosinophils bind LTB4 in a saturable, reversible and specific manner. Scatchard analysis indicated the existence of high-affinity binding sites (Kd1 = 1.00 ± 0.22 nM; Bmax1 = 966 ± 266 sites/cell) and low-affinity binding sites (Kd2 = 62.5 ± 8.9 nM; Bmax2 = 5557 ± 757 sites/cell). The metabolism of LTB4 by alveolar eosinophils in binding conditions was assessed by RP-HPLC and no significant degradation of [3H]LTB4 was observed. LTB4 dose-dependently stimulated eosinophil migration in both chemokinesis and chemotaxis assays with an EC50 value of 1.30 ± 0.14 and 18.14 ± 1.57 nM, respectively. LTB4 caused a dose-dependent increase in the production of superoxide anion with an apparent EC50 value of 50 x 10(-9) M in the authors experimental conditions. LTB4 also induced a dose-dependent increase in the generation of TxA2 with an EC50 value of 46.2 x 10(-9) M. Taken together, their results demonstrated that guinea pig alveolar eosinophils express two classes of specific receptors for LTB4. The high-affinity binding sites seem associated to chemokinesis and chemotaxis whereas the low-affinity binding sites seem associated to superoxide anion production and generation of TxA2. The existence of LTB4 receptors in eosinophils could explain the presence of these cells in hypersensitivity reactions

  20. Immunogenicity, protective efficacy, and non-replicative status of the HSV-2 vaccine candidate HSV529 in mice and guinea pigs.

    Science.gov (United States)

    Bernard, Marie-Clotilde; Barban, Véronique; Pradezynski, Fabrine; de Montfort, Aymeric; Ryall, Robert; Caillet, Catherine; Londono-Hayes, Patricia

    2015-01-01

    HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29) has demonstrated promising efficacy in animal models of genital herpes. However, the immunogenicity, protective efficacy, and non-replicative status of the highly purified clinical vaccine candidate (HSV529) derived from dl5-29 have not been evaluated. Humoral and cellular immune responses were measured in mice and guinea pigs immunized with HSV529. Protection against acute and recurrent genital herpes, mortality, latent infection, and viral shedding after vaginal HSV-2 infection was determined in mice or in naïve and HSV-1 seropositive guinea pigs. HSV529 replication and pathogenicity were investigated in three sensitive models of virus replication: severe combined immunodeficient (SCID/Beige) mice inoculated by the intramuscular route, suckling mice inoculated by the intracranial route, and vaginally-inoculated guinea pigs. HSV529 immunization induced HSV-2-neutralizing antibody production in mice and guinea pigs. In mice, it induced production of specific HSV-2 antibodies and splenocytes secreting IFNγ or IL-5. Immunization effectively prevented HSV-2 infection in all three animal models by reducing mortality, acute genital disease severity and frequency, and viral shedding. It also reduced ganglionic viral latency and recurrent disease in naïve and HSV-1 seropositive guinea pigs. HSV529 replication/propagation was not detected in the muscles of SCID/Beige mice, in the brains of suckling mice, or in vaginal secretions of inoculated guinea pigs. These results confirm the non-replicative status, as well as its immunogenicity and efficacy in mice and guinea pigs, including HSV-1 seropositive guinea pigs. In mice, HSV529 produced Th1/Th2 characteristic immune response thought to be necessary for an effective vaccine. These results further support the clinical investigation of HSV529 in human subjects as a prophylactic vaccine.

  1. Immunogenicity, protective efficacy, and non-replicative status of the HSV-2 vaccine candidate HSV529 in mice and guinea pigs.

    Directory of Open Access Journals (Sweden)

    Marie-Clotilde Bernard

    Full Text Available HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29 has demonstrated promising efficacy in animal models of genital herpes. However, the immunogenicity, protective efficacy, and non-replicative status of the highly purified clinical vaccine candidate (HSV529 derived from dl5-29 have not been evaluated. Humoral and cellular immune responses were measured in mice and guinea pigs immunized with HSV529. Protection against acute and recurrent genital herpes, mortality, latent infection, and viral shedding after vaginal HSV-2 infection was determined in mice or in naïve and HSV-1 seropositive guinea pigs. HSV529 replication and pathogenicity were investigated in three sensitive models of virus replication: severe combined immunodeficient (SCID/Beige mice inoculated by the intramuscular route, suckling mice inoculated by the intracranial route, and vaginally-inoculated guinea pigs. HSV529 immunization induced HSV-2-neutralizing antibody production in mice and guinea pigs. In mice, it induced production of specific HSV-2 antibodies and splenocytes secreting IFNγ or IL-5. Immunization effectively prevented HSV-2 infection in all three animal models by reducing mortality, acute genital disease severity and frequency, and viral shedding. It also reduced ganglionic viral latency and recurrent disease in naïve and HSV-1 seropositive guinea pigs. HSV529 replication/propagation was not detected in the muscles of SCID/Beige mice, in the brains of suckling mice, or in vaginal secretions of inoculated guinea pigs. These results confirm the non-replicative status, as well as its immunogenicity and efficacy in mice and guinea pigs, including HSV-1 seropositive guinea pigs. In mice, HSV529 produced Th1/Th2 characteristic immune response thought to be necessary for an effective vaccine. These results further support the clinical investigation of HSV529 in human subjects as a

  2. Taxonomy Icon Data: Guinea baboon [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available Guinea baboon Papio papio Chordata/Vertebrata/Mammalia/Theria/Eutheria/Primate Papio_papio_L.png Papio_papi...o_NL.png Papio_papio_S.png Papio_papio_NS.png http://biosciencedbc.jp/taxonomy_icon/icon.cgi?i=Papio+papi...o&t=L http://biosciencedbc.jp/taxonomy_icon/icon.cgi?i=Papio+papio&t=NL http://bioscien...cedbc.jp/taxonomy_icon/icon.cgi?i=Papio+papio&t=S http://biosciencedbc.jp/taxonomy_icon/icon.cgi?i=Papio+papio&t=NS ...

  3. Resveratrol anti-ultraviolet-induced guinea pig skin injury

    International Nuclear Information System (INIS)

    Li Wenxing; Zhao Ying

    2014-01-01

    Objective: To Estimate on the protection effect of Stilbene on skin damage induced by ultraviolet radiation. Methods: After the normal skin in guinea pig under the intervene of Resveratrol was irradiated with over- dose of ultraviolet rays (UVB and UVA), the samples in every group were matched and compared. Results: The skin tissue in the Resveratrol intervene group irradiated by ultraviolet rays didn't change obviously as compared with that in the self-control group. But, the damage skin tissue in the control group irradiated by ultraviolet did change significantly as compared with that in the Stilbene intervene group. Conclusion: Resveratrol is a good material to protect the skin from damage effect by ultraviolet radiation. (authors)

  4. Changing pattern of malaria in Bissau, Guinea Bissau

    DEFF Research Database (Denmark)

    Rodrigues, Amabelia; Schellenberg, Joanna Armstrong; Kofoed, Poul-Erik

    2008-01-01

    OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country. METHODS: From May 2003 to May 2004, surveillance for malaria was conducted among children less than 5 years of age at three health centres...... covering the study area of the Bandim Health Project (BHP) and at the outpatient clinic of the national hospital in Bissau. Cross-sectional surveys were conducted in the community in different malaria seasons. RESULTS: Malaria was overdiagnosed in both health centres and hospital. Sixty-four per cent...... of the children who presented at a health centre were clinically diagnosed with malaria, but only 13% of outpatient children who tested for malaria had malaria parasitaemia. Only 44% (963/2193) of children admitted to hospital with a diagnosis of malaria had parasitaemia. The proportion of positive cases...

  5. Assessing Zika virus replication and the development of Zika-specific antibodies after a mid-gestation viral challenge in guinea pigs.

    Science.gov (United States)

    Bierle, Craig J; Fernández-Alarcón, Claudia; Hernandez-Alvarado, Nelmary; Zabeli, Jason C; Janus, Bradley C; Putri, Dira S; Schleiss, Mark R

    2017-01-01

    Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. Animal models that accurately recapitulate congenital Zika syndrome are urgently needed for vaccine development and for the study of ZIKV pathogenesis. As guinea pigs have successfully been used to model transplacental infections by cytomegalovirus, syphilis, and Listeria monocytogenes, we sought to test whether ZIKV could productively infect guinea pigs and whether viral transmission with attendant fetal pathology would occur after a mid-gestation viral challenge. We found that guinea pig cells supported ZIKV replication in vitro. Experimental infection of non-pregnant animals did not result in overt disease but low-level, detectable viremia was observed. When pregnant guinea pigs were challenged with ZIKV at between 18 and 21 days gestational age, ZIKV was not detected in maternal or pup blood, plasma, or tissues and no significant differences in maternal weight gain or pup size were observed following challenge. Nonetheless, a robust antibody response against ZIKV was detected in both the pups and dams. These results suggest that, while guinea pigs can model aspects of the immune response to ZIKV infection during pregnancy, naturally circulating ZIKV strains are not pathogenic during the pregnancy of immunocompetent guinea pigs and do not interfere with normal pup development.

  6. Assessing Zika virus replication and the development of Zika-specific antibodies after a mid-gestation viral challenge in guinea pigs.

    Directory of Open Access Journals (Sweden)

    Craig J Bierle

    Full Text Available Primary Zika virus (ZIKV infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. Animal models that accurately recapitulate congenital Zika syndrome are urgently needed for vaccine development and for the study of ZIKV pathogenesis. As guinea pigs have successfully been used to model transplacental infections by cytomegalovirus, syphilis, and Listeria monocytogenes, we sought to test whether ZIKV could productively infect guinea pigs and whether viral transmission with attendant fetal pathology would occur after a mid-gestation viral challenge. We found that guinea pig cells supported ZIKV replication in vitro. Experimental infection of non-pregnant animals did not result in overt disease but low-level, detectable viremia was observed. When pregnant guinea pigs were challenged with ZIKV at between 18 and 21 days gestational age, ZIKV was not detected in maternal or pup blood, plasma, or tissues and no significant differences in maternal weight gain or pup size were observed following challenge. Nonetheless, a robust antibody response against ZIKV was detected in both the pups and dams. These results suggest that, while guinea pigs can model aspects of the immune response to ZIKV infection during pregnancy, naturally circulating ZIKV strains are not pathogenic during the pregnancy of immunocompetent guinea pigs and do not interfere with normal pup development.

  7. Multistation digisonde observations of equatorial spread F in South America

    Directory of Open Access Journals (Sweden)

    B. W. Reinisch

    2004-09-01

    Full Text Available Directional ionogram and F-region drift observations were conducted at seven digisonde stations in South America during the COPEX campaign from October to December 2002. Five stations in Brazil, one in Argentina, and one in Peru, monitored the ionosphere across the continent to study the onset and development of F-region density depletions that cause equatorial spread F (ESF. New ionosonde techniques quantitatively describe the prereversal uplifting of the F layer at the magnetic equator and the eastward motion of the depletions over the stations. Three of the Brazilian stations were located along a field line with a 350-km apex over the equator to investigate the relation of the occurrence of ESF and the presence of sporadic E-layers at the two E-region intersections of the field line. No simple correlation was found.

  8. Seeding and layering of equatorial spread F by gravity waves

    International Nuclear Information System (INIS)

    Hysell, D.L.; Kelley, M.C.; Swartz, W.E.; Woodman, R.F.

    1990-01-01

    Studies dating back more than 15 years have presented evidence that atmospheric gravity waves play a role in initiating nighttime equatorial F region instabilities. This paper analyzes a spectabular spread F event that for the first time demonstrates a layering which, the authors argue, is controlled by a gravity wave effect. The 50-km vertical wavelength of a gravity wave which they have found is related theoretically to a plasma layering irregularity that originated at low altitudes and then was convected, intact, to higher altitudes. Gravity waves also seem to have determined bottomside intermediate scale undulations, although this fact is not as clear in the data. The neutral wind dynamo effect yields wave number conditions on the gravity wave's ability to modulate the Rayleigh-Taylor instaiblity process. Finally, after evaluating the gravity wave dispersion relation and spatial resonance conditions, we estimate the properties of the seeding wave

  9. Solar cycle signatures in the NCEP equatorial annual oscillation

    Science.gov (United States)

    Mayr, H. G.; Mengel, J. G.; Huang, F. T.; Nash, E. R.

    2009-08-01

    Our analysis of temperature and zonal wind data (1958 to 2006) from the National Center for Atmospheric Research (NCAR) reanalysis (Re-1), supplied by the National Centers for Environmental Prediction (NCEP), shows that the hemispherically symmetric 12-month equatorial annual oscillation (EAO) contains spectral signatures with periods around 11 years. Moving windows of 44 years show that, below 20 km, the 11-year modulation of the EAO is phase locked to the solar cycle (SC). The spectral features from the 48-year data record reveal modulation signatures of 9.6 and 12 years, which produce EAO variations that mimic in limited altitude regimes the varying maxima and minima of the 10.7 cm flux solar index. Above 20 km, the spectra also contain modulation signatures with periods around 11 years, but the filtered variations are too irregular to suggest that systematic SC forcing is the principal agent.

  10. Solar cycle signatures in the NCEP equatorial annual oscillation

    Directory of Open Access Journals (Sweden)

    H. G. Mayr

    2009-08-01

    Full Text Available Our analysis of temperature and zonal wind data (1958 to 2006 from the National Center for Atmospheric Research (NCAR reanalysis (Re-1, supplied by the National Centers for Environmental Prediction (NCEP, shows that the hemispherically symmetric 12-month equatorial annual oscillation (EAO contains spectral signatures with periods around 11 years. Moving windows of 44 years show that, below 20 km, the 11-year modulation of the EAO is phase locked to the solar cycle (SC. The spectral features from the 48-year data record reveal modulation signatures of 9.6 and 12 years, which produce EAO variations that mimic in limited altitude regimes the varying maxima and minima of the 10.7 cm flux solar index. Above 20 km, the spectra also contain modulation signatures with periods around 11 years, but the filtered variations are too irregular to suggest that systematic SC forcing is the principal agent.

  11. Combined radar observations of equatorial electrojet irregularities at Jicamarca

    Directory of Open Access Journals (Sweden)

    D. L. Hysell

    2007-03-01

    Full Text Available Daytime equatorial electrojet plasma irregularities were investigated using five distinct radar diagnostics at Jicamarca including range-time-intensity (RTI mapping, Faraday rotation, radar imaging, oblique scattering, and multiple-frequency scattering using the new AMISR prototype UHF radar. Data suggest the existence of plasma density striations separated by 3–5 km and propagating slowly downward. The striations may be caused by neutral atmospheric turbulence, and a possible scenario for their formation is discussed. The Doppler shifts of type 1 echoes observed at VHF and UHF frequencies are compared and interpreted in light of a model of Farley Buneman waves based on kinetic ions and fluid electrons with thermal effects included. Finally, the up-down and east-west asymmetries evident in the radar observations are described and quantified.

  12. The earth's equatorial principal axes and moments of inertia

    Science.gov (United States)

    Liu, H. S.; Chao, B. F.

    1991-01-01

    The earth's equatorial principal moments of inertia are given as A and B, where A is less than B, and the corresponding principal axes are given as a and b. Explicit formulas are derived for determining the orientation of a and b axes and the difference B - A using C(22) and S(22), the two gravitational harmonic coefficients of degree 2 and order 2. For the earth, the a axis lies along the (14.93 deg W, 165.07 deg E) diameter, and the b axis lies perpendicular to it along the (75.07 deg E, 104.93 deg W) diameter. The difference B - A is 7.260 x 10 to the -6th MR2. These quantities for other planets are contrasted, and geophysical implications are discussed.

  13. Equatorial origin for Lower Jurassic radiolarian chert in the Franciscan Complex, San Rafael Mountains, southern California

    Science.gov (United States)

    Hagstrum, J.T.; Murchey, B.L.; Bogar, R.S.

    1996-01-01

    Lower Jurassic radiolarian chert sampled at two localities in the San Rafael Mountains of southern California (???20 km north of Santa Barbara) contains four components of remanent magnetization. Components A, B???, and B are inferred to represent uplift, Miocene volcanism, and subduction/accretion overprint magnetizations, respectively. The fourth component (C), isolated between 580?? and 680??C, shows a magnetic polarity stratigraphy and is interpreted as a primary magnetization acquired by the chert during, or soon after, deposition. Both sequences are late Pliensbachian to middle Toarcian in age, and an average paleolatitude calculated from all tilt-corrected C components is 1?? ?? 3?? north or south. This result is consistent with deposition of the cherts beneath the equatorial zone of high biologic productivity and is similar to initial paleolatitudes determined for chert blocks in northern California and Mexico. This result supports our model in which deep-water Franciscan-type cherts were deposited on the Farallon plate as it moved eastward beneath the equatorial productivity high, were accreted to the continental margin at low paleolatitudes, and were subsequently distributed northward by strike-slip faulting associated with movements of the Kula, Farallon, and Pacific plates. Upper Cretaceous turbidites of the Cachuma Formation were sampled at Agua Caliente Canyon to determine a constraining paleolatitude for accretion of the Jurassic chert sequences. These apparently unaltered rocks, however, were found to be completely overprinted by the A component of magnetization. Similar in situ directions and demagnetization behaviors observed in samples of other Upper Cretaceous turbidite sequences in southern and Baja California imply that these rocks might also give unreliable results.

  14. Search Results | Page 634 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 6331 - 6340 of 9601 ... West African Platform for HIV Intervention Research (WAPHIR) ... Cheikh Anta Diop), the Gambia (Medical Research Council) and Guinea B ... Improving Food Security in the Highlands of Ethiopia through Improved ...

  15. Search Results | Page 2 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 11 - 20 of 32 ... Conference report on the Regulation of the Private Security Sector in Africa, ... West African Platform for HIV Intervention Research (WAPHIR) ... Cheikh Anta Diop), the Gambia (Medical Research Council) and Guinea B.

  16. The Equatorial Scintillations and Space Weather Effects on its Generation during Geomagnetic Storms

    Science.gov (United States)

    Biktash, Lilia

    Great diversity of the ionospheric phenomena leads to a variety of irregularity types with spatial size from many thousands of kilometers to few centimeters and lifetimes from days to fractions of second. Since the ionosphere strongly influences the propagation of radio waves, signal distortions caused by these irregularities affect short-wave transmissions on Earth, transiono-spheric satellite communications and navigation. In this work the solar wind and the equatorial ionosphere parameters, Kp, Dst, AU, AL indices characterized contribution of different mag-netospheric and ionospheric currents to the H-component of geomagnetic field are examined to test the space weather effect on the generation of ionospheric irregularities producing VLF scintillations. According to the results of the current statistical studies, one can predict scintil-lations from Aarons' criteria using the Dst index, which mainly depicts the magnetospheric ring current field. To amplify Aarons' criteria or to propose new criteria for predicting scintillation characteristics is the question. In the present phase of the experimental investigations of elec-tron density irregularities in the ionosphere new ways are opened up because observations in the interaction between the solar wind -magnetosphere -ionosphere during magnetic storms have progressed greatly. We have examined scintillation relation to magnetospheric and ionospheric currents and show that the factor, which presents during magnetic storms to fully inhibit scin-tillation, is the positive Bz-component of the IMF. During the positive Bz IMF F layer cannot raise altitude where scintillations are formed. The auroral indices and Kp do better for the prediction of the ionospheric scintillations at the equator. The interplanetary magnetic field data and models can be used to explain the relationship between the equatorial ionospheric parameters, h'F, foF2, and the equatorial geomagnetic variations with the polar ionosphere cur-rents and

  17. Evidence for a continuous spectrum of equatorial waves in the Indian Ocean

    Science.gov (United States)

    Eriksen, Charles C.

    1980-06-01

    Seven-month records of current and temperature measurements from a moored array centered at 53°E on the equator in the Indian Ocean are consistent with a continuous spectrum of equatorially trapped internal inertial-gravity, mixed Rossby-gravity, and Kelvin waves. A model spectrum of free linear waves analogous to those for mid-latitude internal gravity waves is used to compute spectra of observed quantities at depths greater than about 2000 m. Model parameters are adjusted to fit general patterns in the observed spectra over periods from roughly 2 days to 1 month. Measurements at shallower depths presumably include forced motions which we have not attempted to model. This `straw-person' spectrum is consistent with the limited data available. The model spectru Ē (n, m, ω) = K · B(m) · C(n, ω), where Ē is an average local energy density in the equatorial wave guide which has amplitude K, wave number shape B(m) ∝ (1 + m/m*)-3, where m is vertical mode number and the bandwidth parameter m* is between 4 and 8, and frequency shape C(n, ω) ∝ [(2n + 1 + s2)½ · σ3]-1 where n is meridional mode number, and s and σ are dimensionless zonal wave number and frequency related by the usual dispersion relation. The scales are (β/cm)½ and (β · cm)½ for horizontal wave number and frequency, where cm is the Kelvin wave speed of the vertical mode m. At each frequency and vertical wave number, energy is partitioned equally among the available inertial gravity modes so that the field tends toward horizontal isotropy at high frequency. The transition between Kelvin and mixed Rossby-gravity motion at low frequency and inertial-gravity motion at high frequency occurs at a period of roughly 1 week. At periods in the range 1-3 weeks, the model spectrum which fits the observations suggests that mixed Rossby-gravity motion dominates; at shorter periods gravity motion dominates. The model results are consistent with the low vertical coherence lengths observed (roughly 80 m

  18. Characteristics of Volcanic Stratospheric Aerosol Layer Observed by CALIOP and Ground Based Lidar at Equatorial Atmosphere Radar Site

    Science.gov (United States)

    Abo, Makoto; Shibata, Yasukuni; Nagasawa, Chikao

    2018-04-01

    We investigated the relation between major tropical volcanic eruptions in the equatorial region and the stratospheric aerosol data, which have been collected by the ground based lidar observations at at Equatorial Atmosphere Radar site between 2004 and 2015 and the CALIOP observations in low latitude between 2006 and 2015. We found characteristic dynamic behavior of volcanic stratospheric aerosol layers over equatorial region.

  19. Ecological dispersal barrier across the equatorial Atlantic in a migratory planktonic copepod

    Science.gov (United States)

    Goetze, Erica; Hüdepohl, Patricia T.; Chang, Chantel; Van Woudenberg, Lauren; Iacchei, Matthew; Peijnenburg, Katja T. C. A.

    2017-11-01

    Resolving the large-scale genetic structure of plankton populations is important to understanding their responses to climate change. However, few studies have reported on the presence and geographic extent of genetically distinct populations of marine zooplankton at ocean-basin scales. Using mitochondrial sequence data (mtCOI, 718 animals) from 18 sites across a basin-scale Atlantic transect (39°N-40°S), we show that populations of the dominant migratory copepod, Pleuromamma xiphias, are genetically subdivided across subtropical and tropical waters (global FST = 0.15, global ΦST = 0.21, both P marine plankton, and we suggest that this may be a dominant mechanism driving the large-scale genetic structure of zooplankton species. Our results also demonstrate the potential importance of the Atlantic equatorial province as a region of evolutionary novelty for the holoplankton.

  20. The optical properties of equatorial cirrus in the pilot radiation observation experiment

    Energy Technology Data Exchange (ETDEWEB)

    Platt, C.M.R.; Young, S.A.; Manson, P.; Patterson, G.R. [CSIRO, Victoria (Australia)] [and others

    1996-04-01

    The development of a sensitive filter radiometer for the Atmospheric Radiation Measurement (ARM) Program has been reported. The aim was to develop a reliable and fast instrument that could be used alongside a lidar to obtain near realtime optical properties of clouds, particularly high ice clouds, as they drifted over an ARM Cloud and Radiation Testbed (CART) site allowing calculation of the radiation divergence in the atmosphere over the site. Obtaining cloud optical properties by the lidar/radiometer, or LIRAD, method was described by Platt et al.; the latter paper also describes a year`s data on mid-latitude cirrus. The optical properties of equatorial cirrus (i.e., cirrus within a few degrees of the equator) have hardly been studied at all. The same is true of tropical cirrus, although a few observations have been reported by Davis and Platt et al.This paper describes obersvations performed on cirrus clouds, analysis methods used, and results.