Topical Meeting on Optics in Adverse Environments

Science.gov (United States)

1987-10-31

The energy required for this process is quite low, on the order of the band gap, and accounts for observed effects induced by radiacions with energy...environment containing the combined effects of solar ultraviolet light, energetic protons, and electrons. 1 By eliminating the metal-enhancing layer

How are topics born? Understanding the research dynamics preceding the emergence of new areas

Directory of Open Access Journals (Sweden)

Angelo A. Salatino

2017-06-01

Full Text Available The ability to promptly recognise new research trends is strategic for many stakeholders, including universities, institutional funding bodies, academic publishers and companies. While the literature describes several approaches which aim to identify the emergence of new research topics early in their lifecycle, these rely on the assumption that the topic in question is already associated with a number of publications and consistently referred to by a community of researchers. Hence, detecting the emergence of a new research area at an embryonic stage, i.e., before the topic has been consistently labelled by a community of researchers and associated with a number of publications, is still an open challenge. In this paper, we begin to address this challenge by performing a study of the dynamics preceding the creation of new topics. This study indicates that the emergence of a new topic is anticipated by a significant increase in the pace of collaboration between relevant research areas, which can be seen as the ‘parents’ of the new topic. These initial findings (i confirm our hypothesis that it is possible in principle to detect the emergence of a new topic at the embryonic stage, (ii provide new empirical evidence supporting relevant theories in Philosophy of Science, and also (iii suggest that new topics tend to emerge in an environment in which weakly interconnected research areas begin to cross-fertilise.

Draft statement by the Watt Committee on Safety and related topics as respects nuclear power

Energy Technology Data Exchange (ETDEWEB)

1982-03-01

The following topics are examined, with particular reference to nuclear power: the nature of risk; waste disposal to the environment (ecological damage and radiation damage due to nuclear plants and fossil-fuel plants); the benefits of nuclear power (including discussion of the following matters: need to conserve fossil fuels; safety; and possibility of diversion to nuclear weapons).

The World Trade Organization and the environment

International Nuclear Information System (INIS)

Rao, P.K.

2000-09-01

This book explains the role and limitations of liberalized international trade on the global environment and sustainable development. A distinguishing feature of this book is an integration of trade, environment and development perspectives for operationally meaningful policy purposes. The topics explored include an analysis of the global trade regimes, their interrelationships with the existing multilateral environmental agreements, institutional mechanisms governed by the World Trade Organization, and a framework for pragmatic reforms. (author)

Numerical simulation on the screw pinch by 2-D MHD pinch code 'topics' including impurities and neutrals effects

International Nuclear Information System (INIS)

Nagata, A.; Ashida, H.; Okamoto, M.; Hirano, K.

1981-03-01

Two dimentional fluid simulation code ''TOPICS'' is developed for the STP-2, the shock heated screw pinch at Nagoya. It involves the effects of impurity ions and neutral atoms. In order to estimate the radiation losses, the impurity continuity equations with ionizations and recombinations are solved simultaneously with the plasma fluid equations. The results are compared with the coronal equilibrium model. It is found that the coronal equilibrium model underestimates the radiation losses from shock heated pinch plasmas in its initial dynamic phase. The present calculations including impurities and neutrals show the importance of the radiation losses from the plasma of the STP-2. Introducing the anomalous resistivity caused by the ion acoustic instability, the observed magnetic field penetration is explained fairly well. (author)

Topics and topic prominence in two sign languages

NARCIS (Netherlands)

Kimmelman, V.

2015-01-01

In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and

Aerodynamics of wind turbines emerging topics

CERN Document Server

Amano, R S

2014-01-01

Focusing on Aerodynamics of Wind Turbines with topics ranging from Fundamental to Application of horizontal axis wind turbines, this book presents advanced topics including: Basic Theory for Wind turbine Blade Aerodynamics, Computational Methods, and Special Structural Reinforcement Technique for Wind Turbine Blades.

New seismic instrumentation packaged for all terrestrial environments (including the quietest observatories!).

Science.gov (United States)

Parker, Tim; Devanney, Peter; Bainbridge, Geoff; Townsend, Bruce

2017-04-01

The march to make every type of seismometer, weak to strong motion, reliable and economically deployable in any terrestrial environment continues with the availability of three new sensors and seismic systems including ones with over 200dB of dynamic range. Until recently there were probably 100 pier type broadband sensors for every observatory type pier, not the types of deployments geoscientists are needing to advance science and monitoring capability. Deeper boreholes are now the recognized quieter environments for best observatory class instruments and these same instruments can now be deployed in direct burial environments which is unprecedented. The experiences of facilities in large deployments of broadband seismometers in continental scale rolling arrays proves the utility of packaging new sensors in corrosion resistant casings and designing in the robustness needed to work reliably in temporary deployments. Integrating digitizers and other sensors decreases deployment complexity, decreases acquisition and deployment costs, increases reliability and utility. We'll discuss the informed evolution of broadband pier instruments into the modern integrated field tools that enable economic densification of monitoring arrays along with supporting new ways to approach geoscience research in a field environment.

Getting Started with Topic Modeling and MALLET

Directory of Open Access Journals (Sweden)

Shawn Graham

2012-09-01

Full Text Available In this lesson you will first learn what topic modeling is and why you might want to employ it in your research. You will then learn how to install and work with the MALLET natural language processing toolkit to do so. MALLET involves modifying an environment variable (essentially, setting up a short-cut so that your computer always knows where to find the MALLET program and working with the command line (ie, by typing in commands manually, rather than clicking on icons or menus. We will run the topic modeller on some example files, and look at the kinds of outputs that MALLET installed. This will give us a good idea of how it can be used on a corpus of texts to identify topics found in the documents without reading them individually.

Animated movies and cartoons in teaching science topics

OpenAIRE

Jeraj, Tina; Susman, Katarina

2016-01-01

Children meet cartoons in their early childhood in their home environment and afterwards also in their school environment. Cartoons and animated movies in teaching process strongly motivates and evoke good learning processes through watching, discussing and active participation in accompanying classroom activities. In this contribution, the survey about the presence of science topics and science sli-ups (errors, in contrary with reality) in selected cartoons is presented. In the research, ten...

Optical techniques for sensing and measurement in hostile environments

International Nuclear Information System (INIS)

Gillespie, C.H.; Greenwell, R.A.

1987-01-01

These proceedings collect papers on optical sensing and measurement in hostile environments. Topic include: nuclear waste storage facility monitoring, monitoring of nuclear and chemical explosions, exhaust gas monitoring, fiber-optic monitoring, temperature and radiation effects on optical fibers, and interferometers

Pesticides and the Environment

Science.gov (United States)

; Environment Human Health Animal Health Safe Use Practices Food Safety Environment Air Water Soil Wildlife Home Page Pesticides and the Environment Related Topics: What Happens to Pesticides Released into the Environment? Pesticide Storage Pesticide Disposal Pesticide Products Integrated Pest Management (IPM) How Safe

The environment and the university - On purpose of the development pattern and of the rural sector in Colombia

International Nuclear Information System (INIS)

Sanchez Acosta, Jairo

2001-01-01

The author in his report includes topics of environmental politics and the rural problem and the violence, the environment and the development pattern, the investigation and the environment among others

Space Environments and Effects Concept: Transitioning Research to Operations and Applications

Science.gov (United States)

Edwards, David L.; Spann, James; Burns, Howard D.; Schumacher, Dan

2012-01-01

The National Aeronautics and Space Administration (NASA) is embarking on a course to expand human presence beyond Low Earth Orbit (LEO) while expanding its mission to explore the solar system. Destinations such as Near Earth Asteroids (NEA), Mars and its moons, and the outer planets are but a few of the mission targets. NASA has established numerous offices specializing in specific space environments disciplines that will serve to enable these missions. To complement these existing discipline offices, a concept focusing on the development of space environment and effects application is presented. This includes space climate, space weather, and natural and induced space environments. This space environment and effects application is composed of 4 topic areas; characterization and modeling, engineering effects, prediction and operation, and mitigation and avoidance. These topic areas are briefly described below. Characterization and modeling of space environments will primarily focus on utilization during Program mission concept, planning, and design phases. Engineering effects includes materials testing and flight experiments producing data to be used in mission planning and design phases. Prediction and operation pulls data from existing sources into decision-making tools and empirical data sets to be used during the operational phase of a mission. Mitigation and avoidance will develop techniques and strategies used in the design and operations phases of the mission. The goal of this space environment and effects application is to develop decision-making tools and engineering products to support the mission phases of mission concept through operations by focusing on transitioning research to operations. Products generated by this space environments and effects application are suitable for use in anomaly investigations. This paper will outline the four topic areas, describe the need, and discuss an organizational structure for this space environments and effects

Review on phytoremediation of uranium-contaminated environment

International Nuclear Information System (INIS)

Zhang Xueli; Wang Erqi

2008-01-01

Phytoremediation, a promising technology using plants to remove radioactive contaminants from the environment or to render them harmless, has become a hot topic in current research. Studies on phytoremediation of uranium-contaminated environment are reviewed with special focuses on several subsets including types of phytoremediation of uranium (such as phytoextraction, rhizofiltration and phytostabilization), influencing factors (such as plant species, soil properties, microorganism, soil amendments, fertilization and uranium speciation) of uranium accumulation by plants, cases studies and trend in phytoremediation of uranium. (authors)

Bare quantifier fronting as contrastive topicalization

Directory of Open Access Journals (Sweden)

Ion Giurgea

2015-11-01

Full Text Available I argue that indefinites (in particular bare quantifiers such as ‘something’, ‘somebody’, etc. which are neither existentially presupposed nor in the restriction of a quantifier over situations, can undergo topicalization in a number of Romance languages (Catalan, Italian, Romanian, Spanish, but only if the sentence contains “verum” focus, i.e. focus on a high degree of certainty of the sentence. I analyze these indefinites as contrastive topics, using Büring’s (1999 theory (where the term ‘S-topic’ is used for what I call ‘contrastive topic’. I propose that the topic is evaluated in relation to a scalar set including generalized quantifiers such as {lP $x P(x, lP MANYx P(x, lP MOSTx P(x, lP “xP(x} or {lP $xP(x, lP P(a, lP P(b …}, and that the contrastive topic is the weakest generalized quantifier in this set. The verum focus, which is part of the “comment” that co-occurs with the “Topic”, introduces a set of alternatives including degrees of certainty of the assertion. The speaker asserts that his claim is certainly true or highly probable, contrasting it with stronger claims for which the degree of probability is unknown. This explains the observation that in downward entailing contexts, the fronted quantified DPs are headed by ‘all’ or ‘many’, whereas ‘some’, small numbers or ‘at least n’ appear in upward entailing contexts. Unlike other cases of non-specific topics, which are property topics, these are quantifier topics: the topic part is a generalized quantifier, the comment is a property of generalized quantifiers. This explains the narrow scope of the fronted quantified DP.

Topical Antibacterials and Global Challenges on Resistance ...

African Journals Online (AJOL)

skin infections can be easily treated with topical antibacterial medication that is available over the counter or by ... infection in minor cut or burn, eyes and ear infection [5]. .... Sensitive/dry skin ... includes both oral and topical antibiotics, but.

Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents.

Science.gov (United States)

Scheinfeld, Noah

2014-07-15

Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n-methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS . Doxepin is available in a 3% or 3.3% concentration (which causes less drowsiness) from compounding pharmacies and can be used in compounded analgesic preparations with positive effect. Topical doxepin is preferred over use of topical amitriptyline because topical doxepin is more effective. Nevertheless, topical amitriptyline increase of the tactile and mechanical nociceptive thresholds and can be used for topical pain control in compound mixture of analgesics . Gabapentin and pregablin can also be used compounded with other agents in topical analgesic preparations with positive topical anesthetic effect. Capsaicin is not useful for topical treatment of the pain of HS. Sometimes compounded of anesthetics medications such as ketamine 10%, bupivacaine 1%, diclofenac 3%, doxepin 3% or 3.3%, and gabapentin 6% can extend the duration of effect so that medication only needs to be used 2 or 3 times a day. Still in my experience the easiest to get and most patient requested agent is topical diclonefac 1% gel.

International symposium on energy, environment and economics: Transactions

International Nuclear Information System (INIS)

Colville, E.J.

1995-01-01

The conference deals with a comprehensive range of topics on energy sources and technologies, the economic impacts of energy use and production, and environmental issues. The papers are grouped into chapters covering environmental policy, environment education, environment economics, new and renewable energy sources, utilities, electricity and planning software, domestic energy, commercial energy, heat pumps and cogeneration, and transport. A number of un-presented papers and abstracts of contributions are included. Relevant papers are individually indexed/abstracted. Tabs. figs., refs

Topics in modern differential geometry

CERN Document Server

Verstraelen, Leopold

2017-01-01

A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

Key Topics in Sports Medicine

OpenAIRE

2006-01-01

Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

Exploring the Relationship Between Distributed Training, Integrated Learning Environments, and Immersive Training Environments

Science.gov (United States)

2007-01-01

educating and training (O’Keefe IV & McIntyre III, 2006). Topics vary widely from standard educational topics such as teaching kids physics, mechanics...Winn, W., & Yu, R. (1997). The Impact of Three Dimensional Immersive Virtual Environments on Modern Pedagogy : Global Change, VR and Learning

“An Environment Built to Include Rather than Exclude Me”: Creating Inclusive Environments for Human Well-Being

Directory of Open Access Journals (Sweden)

Natasha A. Layton

2015-09-01

Full Text Available Contemporary discourses which challenge the notion of health as the “absence of disease” are prompting changes in health policy and practice. People with disability have been influential in progressing our understanding of the impact of contextual factors in individual and population health, highlighting the impact of environmental factors on functioning and inclusion. The World Health Organization’s (WHO more holistic definition of health as “wellbeing” is now applied in frameworks and legislation, and has long been understood in occupational therapy theory. In practice, however, occupational therapists and other professionals often address only local and individual environmental factors to promote wellbeing, within systems and societies that limit equity in population health and restrict inclusion in communities. This paper presents an in-depth analysis of the supports and accommodations identified by a cohort of individuals (n-100 living with disability. A range of environmental facilitators and barriers were identified in peoples’ experience of “inclusive community environs” and found to influence inclusion and wellbeing. The roles and responsibilities of individuals, professionals, and society to enact change in environments are discussed in light of these findings. Recommendations include a focus on the subjective experience of environments, and application of theory from human rights and inclusive economics to address the multiple dimensions and levels of environments in working towards inclusion and wellbeing.

Development and Evaluation of Topical Gabapentin Formulations

Science.gov (United States)

Alcock, Natalie; Hiom, Sarah; Birchall, James C.

2017-01-01

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. PMID:28867811

Topics in quantum theory

International Nuclear Information System (INIS)

Yuille, A.L.

1980-11-01

Topics in the Yang-Mills theories of strong interactions and the quantum theories of gravity are examined, using the path integral approach, including; Yang-Mills instantons in curved spacetimes, Israel-Wilson metrics, Kaehler spacetimes, instantons and anti-instantons. (U.K.)

Armenian media coverage of science topics

Science.gov (United States)

Mkhitaryan, Marie

2016-12-01

The article discusses features and issues of Armenian media coverage on scientific topics and provides recommendations on how to promote scientific topics in media. The media is more interested in social or public reaction rather than in scientific information itself. Medical science has a large share of the global media coverage. It is followed by articles about environment, space, technology, physics and other areas. Armenian media mainly tends to focus on a scientific topic if at first sight it contains something revolutionary. Media primarily reviews whether that scientific study can affect the Armenian economy and only then decides to refer to it. Unfortunately, nowadays the perception of science is a little distorted in media. We can often see headlines of news where is mentioned that the scientist has made "an invention". Nowadays it is hard to see the border between a scientist and an inventor. In fact, the technological term "invention" attracts the media by making illusionary sensation and ensuring large audience. The report also addresses the "Gitamard" ("A science-man") special project started in 2016 in Mediamax that tells about scientists and their motivations.

Topical tags vs non-topical tags : Towards a bipartite classification?

NARCIS (Netherlands)

Basile, Valerio; Peroni, Silvio; Tamburini, Fabio; Vitali, Fabio

2015-01-01

In this paper we investigate whether it is possible to create a computational approach that allows us to distinguish topical tags (i.e. talking about the topic of a resource) and non-topical tags (i.e. describing aspects of a resource that are not related to its topic) in folksonomies, in a way that

Potential Allergens in Disposable Diaper Wipes, Topical Diaper Preparations, and Disposable Diapers: Under-recognized Etiology of Pediatric Perineal Dermatitis.

Science.gov (United States)

Yu, JiaDe; Treat, James; Chaney, Keri; Brod, Bruce

2016-01-01

Allergic contact dermatitis in young children may be an under-recognized cause of perineal dermatitis. The diapered infant skin is uniquely susceptible to allergic contact dermatitis because of more permeable neonatal skin, a moist environment, frequent contact with irritants and resultant skin barrier breakdown, and exposure to topical products such as diaper wipes, diaper preparations, and disposable diapers. To our knowledge, potential allergens in these products have not been thoroughly catalogued or studied. We explore and review potential allergenic ingredients in diaper wipes, topical diaper preparations, and disposable diapers. We analyzed 63 diaper wipes, 41 topical diaper preparations, and the 3 top selling diaper brands available from two of the largest retailers in the United States. Each potential allergen is discussed, and epidemiologic studies of rates of sensitization to potential allergens in children are also reported. Botanical extracts, including members of the Compositae family, were the most commonly represented potential allergen in both diaper wipes and topical preparations. Other potential allergens identified with high frequency include α-tocopherol, fragrances, propylene glycol, parabens, iodopropynyl butylcarbamate, and lanolin. Frequent culprits such as formaldehyde releasers and methylchloroisothiazolinone/methylisothiazolinone were not prevalent in our analyzed products.

Topics in millimeter wave technology

CERN Document Server

Button, Kenneth

1988-01-01

Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

Quantum mechanics II advanced topics

CERN Document Server

Rajasekar, S

2015-01-01

Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

Role of physics in the role in the development and protection of environment. V.2

International Nuclear Information System (INIS)

1992-01-01

This is volume 2 of the proceedings of the 1992 National Physics Conference held in Cairo Egypt. It contains papers on the role that the physics currently plays in the development and protection of the environment. Some of the topics covered include (1) nuclear power production and the environment, (2) solar power and the environment, (3) crystallography and the environment and (4) hazardous effects of nonionising radiations from household equipment

Post-genomic approaches to understanding interactions between fungi and their environment.

Science.gov (United States)

de Vries, Ronald P; Benoit, Isabelle; Doehlemann, Gunther; Kobayashi, Tetsuo; Magnuson, Jon K; Panisko, Ellen A; Baker, Scott E; Lebrun, Marc-Henri

2011-06-01

Fungi inhabit every natural and anthropogenic environment on Earth. They have highly varied life-styles including saprobes (using only dead biomass as a nutrient source), pathogens (feeding on living biomass), and symbionts (co-existing with other organisms). These distinctions are not absolute as many species employ several life styles (e.g. saprobe and opportunistic pathogen, saprobe and mycorrhiza). To efficiently survive in these different and often changing environments, fungi need to be able to modify their physiology and in some cases will even modify their local environment. Understanding the interaction between fungi and their environments has been a topic of study for many decades. However, recently these studies have reached a new dimension. The availability of fungal genomes and development of post-genomic technologies for fungi, such as transcriptomics, proteomics and metabolomics, have enabled more detailed studies into this topic resulting in new insights. Based on a Special Interest Group session held during IMC9, this paper provides examples of the recent advances in using (post-)genomic approaches to better understand fungal interactions with their environments.

Alive and inseparable : British Columbia's coastal environment : 2006

International Nuclear Information System (INIS)

Gilkeson, L.; Bonner, L.; Brown, R.; Francis, K.; Johanneson, D.; Canessa, R.; Paynter, R.

2006-01-01

The coastal population of British Columbia is projected to increase by a million people over the next 20 years. Population growth in the region will increase pressure on the environment through land-use changes and water demand, and the discharge of wastes and pollutants. Changes to the environment will have an impact on industries such as forestry, fishing, and tourism that depend on healthy ecosystems. Six technical papers were presented in this volume as part of a project reporting on the coastal environment of British Columbia. The volume was compiled to help in the future-decision making processes in the province. Reporting for the project focused on a region extending westward from the height of the Coast Mountains, and included the marine area within Canada's 200-mile limit. Papers were presented on the following topics: (1) population and economic activity; (2) climate change; (3) industrial contaminants; (4) ecosystem protection; (5) bio-diversity; and (6) fisheries. Each of the 6 papers provided an overview of issues related to their topic, a set of indicators, and a summary of results. refs., tabs., figs

Development and Evaluation of Topical Gabapentin Formulations

Directory of Open Access Journals (Sweden)

Christopher J. Martin

2017-08-01

Full Text Available Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w gabapentin 0.75% (w/w Carbopol® hydrogels containing 5% (w/w DMSO or 70% (w/w ethanol and a compounded 10% (w/w gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations.

Task-Driven Comparison of Topic Models.

Science.gov (United States)

Alexander, Eric; Gleicher, Michael

2016-01-01

Topic modeling, a method of statistically extracting thematic content from a large collection of texts, is used for a wide variety of tasks within text analysis. Though there are a growing number of tools and techniques for exploring single models, comparisons between models are generally reduced to a small set of numerical metrics. These metrics may or may not reflect a model's performance on the analyst's intended task, and can therefore be insufficient to diagnose what causes differences between models. In this paper, we explore task-centric topic model comparison, considering how we can both provide detail for a more nuanced understanding of differences and address the wealth of tasks for which topic models are used. We derive comparison tasks from single-model uses of topic models, which predominantly fall into the categories of understanding topics, understanding similarity, and understanding change. Finally, we provide several visualization techniques that facilitate these tasks, including buddy plots, which combine color and position encodings to allow analysts to readily view changes in document similarity.

Topical cyclosporine for atopic keratoconjunctivitis.

Science.gov (United States)

González-López, Julio J; López-Alcalde, Jesús; Morcillo Laiz, Rafael; Fernández Buenaga, Roberto; Rebolleda Fernández, Gema

2012-09-12

Ophthalmologica Europaea from 2005 to July 2011. We included randomised controlled trials only. Two review authors independently extracted data. Due to the small number of studies and the diversity of outcome measures, interventions and participants, we presented results narratively. We found three RCTs with a total of 58 participants that were eligible for inclusion. There was significant variability between the trials in interventions, methodology and outcome measures and therefore we did not perform meta-analysis.One study reported on the use of 2% CsA in maize oil and two on the use of a commercial emulsion of 0.05% CsA. Of these three studies, one showed a beneficial effect of topical CsA in controlling signs and symptoms of AKC, one in controlling signs of AKC and one did not show evidence of an improvement. Only two studies analysed the effect of topical CsA in reducing topical steroid use; one showed a significant reduction in topical steroid use with CsA, but the other did not show evidence of this improvement. No serious adverse events were reported in the trials. This systematic review highlights the relative scarcity of controlled clinical trials assessing the efficacy of topical CsA therapy in AKC and suggests that evidence on the efficacy and safety of topical CsA treatment in patients with CsA remains limited. However, the data suggest that topical CsA may provide clinical and symptomatic relief in AKC and may help to reduce topical steroid use in patients with steroid-dependent or steroid-resistant AKC. No serious adverse events were reported. Reported adverse events in patients treated with topical CsA include intense stinging and eyelid skin maceration. One patient in the placebo group developed a severe allergic response to maize antigens. However, the total number of patients in the trials was too small to assess the safety of this treatment.Additional well-designed and powered RCTs of topical CsA in AKC are needed. Ideal study designs should include adequate

Chemistry for protection of the environment, Eight international conference: Proceedings

International Nuclear Information System (INIS)

Lacy, W.J.; Pawlowski, L.; Dlugosz, J.J.

1991-01-01

This report presents research programs from the International Conference on the Chemistry For Protection of the Environment. Topics covered include environmental transport, waste minimization, pollution control and prevention, waste management, soil remediation, and health concerns associated with environmental contamination. Individual projects are processed separately for the data bases

Influence of number of topics, topic duration, and curricular focus on biology achievement of Population 3 TIMSS countries

Science.gov (United States)

Hodges, Eddie Louis

The purposes of this study were to determine if a relationship exists between biology achievement and (1) number of topics, (2) topic duration, (3) curricular focus, and (4) science achievement using TIMSS data from Population 3---the final year of secondary school. Students included in this study were subsets of the 55,675 students from 22 countries who participated in the science literacy portion of TIMSS at the Population 3 level (IEA, 1997). The sample included in this study for the four research questions were comprised of between (1) 17,769 and 37,794 students from 15 countries, (2) 17,769 and 37,794 students from 15 countries, (3) 21,715 and 46,458 students from 18 countries, and (4) 19,518 and 46,458 students from 18 countries, respectively. A Pearson's product moment correlation was used to determine whether a relationship exists between the number of biology topics addressed by intended national science curricula and mean student achievement on selected items by country. No statistically significant correlation was found by country between biology achievement and number of topics. To determine whether a relationship exists between the topic duration of biology topics addressed by released, biology-oriented, Population 3 Science Literacy items and student achievement on those items, a Pearson's product moment correlation was also used. A statistically significant correlation between biology achievement and topic duration for only one topic (Interdependence of Life) was found at the .05 level of significance. A possible relationship between the degree of curricular focus of Population 3 TIMSS countries and student achievement on selected items by country was evaluated using a Pearson's product moment correlation. No statistically significant correlation by country between biology achievement and degree of curricular focus was found. A Pearson's product moment correlation was used to determine whether a relationship exists between science literacy

Selected topics in e+e- physics

International Nuclear Information System (INIS)

Sau Lan Wu

1981-01-01

Selected topics of recent experimental results from the high-energy electron-positron storage rings are presented. The topics include some of the tau and charm physics from SPEAR, the upsilon physics from DORIS and CESR, and the γγ physics and quark and gluon physics from the PLUTO and TASSO Collaborations at PETRA. Related data from the JADE and MARK J Collaborations at PETRA are discussed in separated papers at this school. (orig.)

SETI: A good introductory physics topic

Science.gov (United States)

Hobson, Art

1997-04-01

If America is to achieve the science literacy that is essential to industrialized democracy, all students must study such topics as scientific methodology, pseudoscience, ozone depletion, and global warming. My large-enrollment liberal-arts physics course covers the great principles of physics along with several such philosophical and societal topics. It is easy to include the interdisciplinary context of physics in courses for non-scientists, because these courses are flexible, conceptual, and taught to students whose interests span a broad range. Students find these topics relevant and fascinating, leading to large enrollments by non-scientists even in courses labeled ''physics.'' I will discuss my approach to teaching the search for extra-terrestrial intelligence (SETI), a topic with lots of good physics and with connections to scientific methodology and pseudoscience. A textbook for this kind of course has been published, Physics: Concepts and Connections (Prentice-Hall, 1995).

Neutron spectrometry and dosimetry in the environment and at workplaces

International Nuclear Information System (INIS)

Alevra, A.V.; Klein, H.; Knauf, K.; Wittstock, J.; Wolber, G.

1998-01-01

Results obtained in diverse environments (including workplaces) using both spectrometric and dosimetric instrumentation were compared. The following topics are included: PTB Bonner sphere spectrometers; natural cosmic ray-induced neutron background; neutron fields at the Dukovany nuclear power plant (Czech Republic); neutron fields at the isochronous cyclotron of the German Cancer Research center in Heidelberg; and accuracy of the integral results obtained with Bonner spheres. (P.A.)

Integrated model of port oil piping transportation system safety including operating environment threats

Directory of Open Access Journals (Sweden)

Kołowrocki Krzysztof

2017-06-01

Full Text Available The paper presents an integrated general model of complex technical system, linking its multistate safety model and the model of its operation process including operating environment threats and considering variable at different operation states its safety structures and its components safety parameters. Under the assumption that the system has exponential safety function, the safety characteristics of the port oil piping transportation system are determined.

Integrated model of port oil piping transportation system safety including operating environment threats

OpenAIRE

Kołowrocki, Krzysztof; Kuligowska, Ewa; Soszyńska-Budny, Joanna

2017-01-01

The paper presents an integrated general model of complex technical system, linking its multistate safety model and the model of its operation process including operating environment threats and considering variable at different operation states its safety structures and its components safety parameters. Under the assumption that the system has exponential safety function, the safety characteristics of the port oil piping transportation system are determined.

Topical phenytoin for treating pressure ulcers.

Science.gov (United States)

Hao, Xiang Yong; Li, Hong Ling; Su, He; Cai, Hui; Guo, Tian Kang; Liu, Ruifeng; Jiang, Lei; Shen, Yan Fei

2017-02-22

Pressure ulcers are common in clinical practice and pose a significant health problem worldwide. Apart from causing suffering to patients, they also result in longer hospital stays and increase the cost of health care. A variety of methods are used for treating pressure ulcers, including pressure relief, patient repositioning, biophysical strategies, nutritional supplementation, debridement, topical negative pressure, and local treatments including dressings, ointments and creams such as bacitracin, silver sulphadiazine, neomycin, and phenytoin. Phenytoin is a drug more commonly used in the treatment of epilepsy, but may play an important role in accelerating ulcer healing. To assess the effects of topical phenytoin on the rate of healing of pressure ulcers of any grade, in any care setting. In September 2016, we searched the following electronic databases to identify relevant randomized clinical trials: the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library); Ovid MEDLINE; Ovid Embase; and EBSCO CINAHL Plus. We handsearched conference proceedings from the European Pressure Ulcer Advisory Panel, European Wound Management Association and the Tissue Viability Society for all available years. We searched the references of the retrieved trials to identify further relevant trials. We also searched clinical trials registries to identify ongoing and unpublished studies. There were no restrictions with respect to language, date of publication or study setting. We included all randomized controlled trials (RCTs) addressing the effects (both benefits and harms) of topical phenytoin on the healing of pressure ulcers of any grade compared with placebo or alternative treatments or no therapy, irrespective of blinding, language, and publication status. Two review authors independently selected studies, extracted information on participants, interventions, methods and results and assessed risk of bias using

E-Learning Systems, Environments and Approaches

OpenAIRE

Isaias, P.; Spector, J.M.; Ifenthaler, D.; Sampson, D.G.

2015-01-01

The volume consists of twenty-five chapters selected from among peer-reviewed papers presented at the CELDA (Cognition and Exploratory Learning in the Digital Age) 2013 Conference held in Fort Worth, Texas, USA, in October 2013 and also from world class scholars in e-learning systems, environments and approaches. The following sub-topics are included: Exploratory Learning Technologies (Part I), e-Learning social web design (Part II), Learner communities through e-Learning implementations (Par...

Topical problems of nuclear law viewed internationally

International Nuclear Information System (INIS)

Bischof, W.

1978-01-01

The International Nuclear Law Association, on its 3rd Congress Nuclear Inter Jura from October 2-5, 1977 in Italy, dealt with a number of topical problems of nuclear law, in particular aspects concerning agreements in connection with the construction of nuclear facilities, the influence of nuclear energy on the environment and the public acceptance, third party liability, and nuclear insurance, radiation protection law and international judicial problems. (orig.) [de

Interviews concerning topical questions in nuclear technology

International Nuclear Information System (INIS)

Segatz, U.; Schatz, A.; Stephany, M.; Michaelis, H.

1978-01-01

On the occasion of the Nuclex meeting, October 3-7, 1978, Basle/Switzerland, the editorial department of 'Atom und Strom' questioned some leading scientists in nuclear technology on particularly relevant topics. The following subjects were discussed: - How long can we do without nuclear energy, - Modern technology for nuclear power plants, - Nuclear fuel cycle and environment, - Nuclear energy and European Communities, - Nuclear energy and its risks (reflections on incidents). (orig./UA) [de

Open access in the critical care environment.

Science.gov (United States)

South, Tabitha; Adair, Brigette

2014-12-01

Open access has become an important topic in critical care over the last 3 years. In the past, critical care had restricted access and set visitation guidelines to protect patients. This article provides a review of the literature related to open access in the critical care environment, including the impact on patients, families, and health care providers. The ultimate goal is to provide care centered on patients and families and to create a healing environment to ensure safe passage of patients through their hospital stays. This outcome could lead to increased patient/family satisfaction. Copyright © 2014 Elsevier Inc. All rights reserved.

Changing the Topic. Topic Position in Ancient Greek Word Order

NARCIS (Netherlands)

Allan, R.J.

2014-01-01

Ancient Greek, topics can be expressed as intra-clausal constituents but they can also precede or follow the main clause as extra-clausal constituents. Together, these various topic expressions constitute a coherent system of complementary pragmatic functions. For a comprehensive account of topic

topicmodels: An R Package for Fitting Topic Models

Directory of Open Access Journals (Sweden)

Bettina Grun

2011-05-01

Full Text Available Topic models allow the probabilistic modeling of term frequency occurrences in documents. The fitted model can be used to estimate the similarity between documents as well as between a set of specified keywords using an additional layer of latent variables which are referred to as topics. The R package topicmodels provides basic infrastructure for fitting topic models based on data structures from the text mining package tm. The package includes interfaces to two algorithms for fitting topic models: the variational expectation-maximization algorithm provided by David M. Blei and co-authors and an algorithm using Gibbs sampling by Xuan-Hieu Phan and co-authors.

Challenges for Life Support Systems in Space Environments, Including Food Production

Science.gov (United States)

Wheeler, Raymond M.

2012-01-01

Environmental Control and Life Support Systems (ECLSS) refer to the technologies needed to sustain human life in space environments. Histor ically these technologies have focused on providing a breathable atmo sphere, clean water, food, managing wastes, and the associated monitoring capabilities. Depending on the space agency or program, ELCSS has sometimes expanded to include other aspects of managing space enviro nments, such as thermal control, radiation protection, fire detection I suppression, and habitat design. Other times, testing and providing these latter technologies have been associated with the vehicle engi neering. The choice of ECLSS technologies is typically driven by the mission profile and their associated costs and reliabilities. These co sts are largely defined by the mass, volume, power, and crew time req uirements. For missions close to Earth, e.g., low-Earth orbit flights, stowage and resupply of food, some 0 2, and some water are often the most cost effective option. But as missions venture further into spa ce, e.g., transit missions to Mars or asteroids, or surface missions to Moon or Mars, the supply line economics change and the need to clos e the loop on life support consumables increases. These are often ref erred to as closed loop or regenerative life support systems. Regardless of the technologies, the systems must be capable of operating in a space environment, which could include micro to fractional g setting s, high radiation levels, and tightly closed atmospheres, including perhaps reduced cabin pressures. Food production using photosynthetic o rganisms such as plants by nature also provides atmospheric regenerat ion (e.g., CO2 removal and reduction, and 0 2 production), yet to date such "bioregenerative" technologies have not been used due largely t o the high power requirements for lighting. A likely first step in te sting bioregenerative capabilities will involve production of small a mounts of fresh foods to supplement to crew

Human-Computer Interaction in Smart Environments

Science.gov (United States)

Paravati, Gianluca; Gatteschi, Valentina

2015-01-01

Here, we provide an overview of the content of the Special Issue on “Human-computer interaction in smart environments”. The aim of this Special Issue is to highlight technologies and solutions encompassing the use of mass-market sensors in current and emerging applications for interacting with Smart Environments. Selected papers address this topic by analyzing different interaction modalities, including hand/body gestures, face recognition, gaze/eye tracking, biosignal analysis, speech and activity recognition, and related issues.

Environment stakes and policies

International Nuclear Information System (INIS)

Tronquoy, Ph.

2002-01-01

This document devoted to the environment discusses on the following topics: the environmental policies, the threats for the environment (climatic change, water management and risks), the deforestation, the sustainable development of cities, the safety first principle, the energy challenge, the international cooperation, the North-South relations. (A.L.B.)

Topical antifungal agents: an update.

Science.gov (United States)

Diehl, K B

1996-10-01

So many topical antifungal agents have been introduced that it has become very difficult to select the proper agent for a given infection. Nonspecific agents have been available for many years, and they are still effective in many situations. These agents include Whitfield's ointment, Castellani paint, gentian violet, potassium permanganate, undecylenic acid and selenium sulfide. Specific antifungal agents include, among others, the polyenes (nystatin, amphotericin B), the imidazoles (metronidazole, clotrimazole) and the allylamines (terbinafine, naftifine). Although the choice of an antifungal agent should be based on an accurate diagnosis, many clinicians believe that topical miconazole is a relatively effective agent for the treatment of most mycotic infections. Terbinafine and other newer drugs have primary fungicidal effects. Compared with older antifungal agents, these newer drugs can be used in lower concentrations and shorter therapeutic courses. Studies are needed to evaluate the clinical efficacies and cost advantages of both newer and traditional agents.

Nuclear Energy and the Environment.

Science.gov (United States)

International Atomic Energy Agency, Vienna (Austria).

"Nuclear Energy and the Environment" is a pocket folder of removable leaflets concerned with two major topics: Nuclear energy and Nuclear Techniques. Under Nuclear Energy, leaflets concerning the topics of "Radiation--A Fact of Life,""The Impact of a Fact: 1963 Test Ban Treaty,""Energy Needs and Nuclear Power,""Power Reactor Safety,""Transport,"…

Mitigation of pollutants for clean environment: proceedings of the fifteenth national symposium on environment

International Nuclear Information System (INIS)

Puranik, V.D.; Pandit, G.G.; Ramachandran, T.V.; Tripathi, R.M.; Saradhi, I.V.; Hegde, A.G.

2007-01-01

The main theme of this volume is mitigation of pollutants for clean environment. The topics covered are technologies for clean environment, monitoring and modeling of pollutants and their transport, environmental radioactivity, environmental awareness, education and regulatory aspects. Papers relevant to INIS are indexed separately

An overview of topical treatment for atopic eczema | Motswaledi ...

African Journals Online (AJOL)

... on the elbows and knees in younger children, and the cubital and popliteal fossae in older children and adults. Treatment modalities include emollients, topical corticosteroids, calcineurin inhibitors, phototherapy and immunosuppressive therapy. This article provides a brief overview of topical treatments for atopic eczema.

Learning environment, learning styles and conceptual understanding

Science.gov (United States)

Ferrer, Lourdes M.

1990-01-01

In recent years there have been many studies on learners developing conceptions of natural phenomena. However, so far there have been few attempts to investigate how the characteristics of the learners and their environment influence such conceptions. This study began with an attempt to use an instrument developed by McCarthy (1981) to describe learners in Malaysian primary schools. This proved inappropriate as Asian primary classrooms do not provide the same kind of environment as US classrooms. It was decided to develop a learning style checklist to suit the local context and which could be used to describe differences between learners which teachers could appreciate and use. The checklist included four dimensions — perceptual, process, self-confidence and motivation. The validated instrument was used to determine the learning style preferences of primary four pupils in Penang, Malaysia. Later, an analysis was made regarding the influence of learning environment and learning styles on conceptual understanding in the topics of food, respiration and excretion. This study was replicated in the Philippines with the purpose of investigating the relationship between learning styles and achievement in science, where the topics of food, respiration and excretion have been taken up. A number of significant relationships were observed in these two studies.

Radiation risks -a possible teaching topic

International Nuclear Information System (INIS)

Howes, R.W.

1975-01-01

Radiation risks has been the subject of hot debate since 1969 due in main to the energy crisis and the switch to nuclear power. Topics of this debate including; the controversy concerned with the late radiobiological effects of low level radiation, the social responsibility of modern scientists, the sometimes acrimonious discussion which has taken place over many years concerning radiation standards, and present day misgivings over the environmental aspect of the nuclear power programme, are discussed and suggestions are made of ways in which the topics could be introduced into teaching courses. (U.K.)

Human-Computer Interaction in Smart Environments

Directory of Open Access Journals (Sweden)

Gianluca Paravati

2015-08-01

Full Text Available Here, we provide an overview of the content of the Special Issue on “Human-computer interaction in smart environments”. The aim of this Special Issue is to highlight technologies and solutions encompassing the use of mass-market sensors in current and emerging applications for interacting with Smart Environments. Selected papers address this topic by analyzing different interaction modalities, including hand/body gestures, face recognition, gaze/eye tracking, biosignal analysis, speech and activity recognition, and related issues.

Aquatic and Terrestrial Environment 2004

DEFF Research Database (Denmark)

Andersen, J. M.; Boutrup, S.; Bijl, L. van der

This report presents the 2004 results of the Danish National Monitoring and Assess-ment Programme for the Aquatic and Terrestrial Environments (NOVANA). 2004 was the first year in which terrestrial nature was included in the monitoring pro-gramme. The report reviews the state of the groundwater......, watercourses, lakes and marine waters and the pressures upon them and reviews the monitoring of terrestrial natural habitats and selected plants and animals. The report is based on the annual reports prepared for each subprogramme by the Topic Centres. The latter reports are mainly based on data collected...

Gastrointestinal Bleeding: MedlinePlus Health Topic

Science.gov (United States)

... are many possible causes of GI bleeding, including hemorrhoids , peptic ulcers , tears or inflammation in the esophagus, ... blood Show More Show Less Related Health Topics Hemorrhoids Peptic Ulcer National Institutes of Health The primary ...

Evaluating topic models with stability

CSIR Research Space (South Africa)

De Waal, A

2008-11-01

Full Text Available Topic models are unsupervised techniques that extract likely topics from text corpora, by creating probabilistic word-topic and topic-document associations. Evaluation of topic models is a challenge because (a) topic models are often employed...

Topical report review status

International Nuclear Information System (INIS)

1997-08-01

This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review schedules, of all topical reports currently accepted for review by the NRC. This report will be published annually. Each sponsoring organization with one or more topical reports accepted for review copies

Environment: General; Grammar & Usage; Money Management; Music History; Web Page Creation & Design.

Science.gov (United States)

Web Feet, 2001

2001-01-01

Describes Web site resources for elementary and secondary education in the topics of: environment, grammar, money management, music history, and Web page creation and design. Each entry includes an illustration of a sample page on the site and an indication of the grade levels for which it is appropriate. (AEF)

Topics in field theory

CERN Document Server

Karpilovsky, G

1989-01-01

This monograph gives a systematic account of certain important topics pertaining to field theory, including the central ideas, basic results and fundamental methods.Avoiding excessive technical detail, the book is intended for the student who has completed the equivalent of a standard first-year graduate algebra course. Thus it is assumed that the reader is familiar with basic ring-theoretic and group-theoretic concepts. A chapter on algebraic preliminaries is included, as well as a fairly large bibliography of works which are either directly relevant to the text or offer supplementary material of interest.

Recent advances and perspectives in topical oral anesthesia.

Science.gov (United States)

Franz-Montan, Michelle; Ribeiro, Lígia Nunes de Morais; Volpato, Maria Cristina; Cereda, Cintia Maria Saia; Groppo, Francisco Carlos; Tofoli, Giovana Randomille; de Araújo, Daniele Ribeiro; Santi, Patrizia; Padula, Cristina; de Paula, Eneida

2017-05-01

Topical anesthesia is widely used in dentistry to reduce pain caused by needle insertion and injection of the anesthetic. However, successful anesthesia is not always achieved using the formulations that are currently commercially available. As a result, local anesthesia is still one of the procedures that is most feared by dental patients. Drug delivery systems (DDSs) provide ways of improving the efficacy of topical agents. Areas covered: An overview of the structure and permeability of oral mucosa is given, followed by a review of DDSs designed for dental topical anesthesia and their related clinical trials. Chemical approaches to enhance permeation and anesthesia efficacy, or to promote superficial anesthesia, include nanostructured carriers (liposomes, cyclodextrins, polymeric nanoparticle systems, solid lipid nanoparticles, and nanostructured lipid carriers) and different pharmaceutical dosage forms (patches, bio- and mucoadhesive systems, and hydrogels). Physical methods include pre-cooling, vibration, iontophoresis, and microneedle arrays. Expert opinion: The combination of different chemical and physical methods is an attractive option for effective topical anesthesia in oral mucosa. This comprehensive review should provide the readers with the most relevant options currently available to assist pain-free dental anesthesia. The findings should be considered for future clinical trials.

Syntacticized topics in Kurmuk

DEFF Research Database (Denmark)

Andersen, Torben

2015-01-01

This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct....... The grammatical relation of the topic is expressed by a voice-like inflection of the verb, here called orientation. While subject-orientation is morphologically unmarked, object-oriented and adjunct-oriented verbs are marked by a subject suffix or by a suffix indicating that the topic is not subject, and adjunct......-orientation differs from object-orientation by a marked tone pattern. Topic choice largely reflects information structure by indicating topic continuity. The topic also plays a crucial role in relative clauses and in clauses with contrastive constituent focus, in that objects and adjuncts can only be relativized...

Health-related hot topic detection in online communities using text clustering.

Directory of Open Access Journals (Sweden)

Yingjie Lu

Full Text Available Recently, health-related social media services, especially online health communities, have rapidly emerged. Patients with various health conditions participate in online health communities to share their experiences and exchange healthcare knowledge. Exploring hot topics in online health communities helps us better understand patients' needs and interest in health-related knowledge. However, the statistical topic analysis employed in previous studies is becoming impractical for processing the rapidly increasing amount of online data. Automatic topic detection based on document clustering is an alternative approach for extracting health-related hot topics in online communities. In addition to the keyword-based features used in traditional text clustering, we integrate medical domain-specific features to represent the messages posted in online health communities. Three disease discussion boards, including boards devoted to lung cancer, breast cancer and diabetes, from an online health community are used to test the effectiveness of topic detection. Experiment results demonstrate that health-related hot topics primarily include symptoms, examinations, drugs, procedures and complications. Further analysis reveals that there also exist some significant differences among the hot topics discussed on different types of disease discussion boards.

Topical Session on Materials Management

International Nuclear Information System (INIS)

2002-01-01

At its second meeting, in Paris, 5-7 December 2001, the WPDD held two topical sessions on the D and D Safety Case and on the Management of Materials from D and D, respectively. This report documents the topical session on the management of materials. Presentations during the topical session covered key aspects of the management of materials and meant to provide an exchange of information and experience, including: Experience and lessons learnt from VLLW and non-radioactive material management in Spain and Germany with special attention to recycling (How specific solutions came about? Are there 'generic' examples for wider adoption?); Risk assessment of recycling and non-recycling: a CPD study; Waste acceptance issues within different national contexts (What constraints are there on the waste receiving body and what flexibility can the latter have? What constraints does this impose on D and D implementers? What about wastes are without current solution? What needs to be done? What about large items and 'difficult' waste in general?); Radiological characterisation of materials during decommissioning, particularly difficult situations - large volumes, large items,.. wastes, heterogeneous streams (What examples of established practice? What are the approaches or aspects that set the regulatory requirements? How can the flow rates be large but the answers acceptable? How much is needed to be known for later action, e. g., disposal, release, protection of worker, etc.); Radiological characterisation of buildings as they stand, in order to allow conventional demolition (What are strategies for optimisation of characterisation? How much needs to be known to take action later? e.g. for storage, disposal, release, cost estimation and ALARA? What needs to be done in advance and after decommissioning/dismantling?). At the end of each presentation time was allotted for discussion of the paper. Integral to the Topical Session was a facilitated plenary discussion on the topical

Conference on Stochastic Analysis and Related Topics

CERN Document Server

Peterson, Jonathon

2017-01-01

The articles in this collection are a sampling of some of the research presented during the conference “Stochastic Analysis and Related Topics”, held in May of 2015 at Purdue University in honor of the 60th birthday of Rodrigo Bañuelos. A wide variety of topics in probability theory is covered in these proceedings, including heat kernel estimates, Malliavin calculus, rough paths differential equations, Lévy processes, Brownian motion on manifolds, and spin glasses, among other topics.

Advances in Small Remotely Piloted Aircraft Communications and Remote Sensing in Maritime Environments including the Arctic

Science.gov (United States)

McGillivary, P. A.; Borges de Sousa, J.; Wackowski, S.; Walker, G.

2011-12-01

Small remotely piloted aircraft have recently been used for maritime remote sensing, including launch and retrieval operations from land, ships and sea ice. Such aircraft can also function to collect and communicate data from other ocean observing system platforms including moorings, tagged animals, drifters, autonomous surface vessels (ASVs), and autonomous underwater vessels (AUVs). The use of small remotely piloted aircraft (or UASs, unmanned aerial systems) with a combination of these capabilities will be required to monitor the vast areas of the open ocean, as well as in harsh high-latitude ecosystems. Indeed, these aircraft are a key component of planned high latitude maritime domain awareness environmental data collection capabilities, including use of visible, IR and hyperspectral sensors, as well as lidar, meteorological sensors, and interferometric synthetic aperture radars (ISARs). We here first describe at-sea demonstrations of improved reliability and bandwidth of communications from ocean sensors on autonomous underwater vehicles to autonomous surface vessels, and then via remotely piloted aircraft to shore, ships and manned aircraft using Delay and Disruption Tolerant (DTN) communication protocols. DTN enables data exchange in communications-challenged environments, such as remote regions of the ocean including high latitudes where low satellite angles and auroral disturbances can be problematic. DTN provides a network architecture and application interface structured around optionally-reliable asynchronous message forwarding, with limited expectations of end-to-end connectivity and node resources. This communications method enables aircraft and surface vessels to function as data mules to move data between physically disparate nodes. We provide examples of the uses of this communication protocol for environmental data collection and data distribution with a variety of different remotely piloted aircraft in a coastal ocean environment. Next, we

Topical Drugs for Pain Relief

Directory of Open Access Journals (Sweden)

Anjali Srinivasan

2015-03-01

Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

Environment, safety and health

International Nuclear Information System (INIS)

Luzianovich, L.Ch.; Fardeau, J.C.; Darras, M.

2000-01-01

Environment, safety and health were the three topics discussed by the WOC 8 working group of the worldwide gas congress. Environment protection has become a major preoccupation and constraint for natural gas industry at the dawn of the new millennium. It is closely linked with the safety of installation and with the health of workmen who exploit or use natural gas energy: methane emissions, health and safety in gas industry, environment management and evaluation. (J.S.)

Periorbital muscle atrophy associated with topical bimatoprost therapy

OpenAIRE

Wang, Priscilla Xinhui; Koh, Victor Teck Chang; Cheng, Jin Fong

2014-01-01

Priscilla Xinhui Wang, Victor Teck Chang Koh, Jin Fong ChengDepartment of Ophthalmology, National University Health System, SingaporeAbstract: Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocular hyperaemia, ocular pruritus, and periocular and iris pigmentary changes. Perioribital lipodystrophy is another well-documented outcome associated with chronic use of topical bimatoprost, which re...

Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch.

Science.gov (United States)

Lionberger, David R; Brennan, Michael J

2010-11-10

The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP) in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs), diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978-2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5-1.9). In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs). The physical-chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions.

EMaCC: FY-1978 topical area report

International Nuclear Information System (INIS)

1979-04-01

Materials research and development in the energy program are briefly described. Topics reviewed include joining of materials, elastomers, catalysts and catalytic effect, radiation effects, superconductivity, cement, concrete, and alternate materials

Topical report review status

International Nuclear Information System (INIS)

1982-08-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

Topical report review status

International Nuclear Information System (INIS)

1983-01-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch

Directory of Open Access Journals (Sweden)

David R Lionberger

2010-11-01

Full Text Available David R Lionberger1, Michael J Brennan21Southwest Orthopedic Group, Houston, TX, USA; 2Department of Medicine, Bridgeport Hospital, Bridgeport, CT, USAAbstract: The objective of this article is to review published clinical data on diclofenac epolamine topical patch 1.3% (DETP in the treatment of acute soft tissue injuries, such as strains, sprains, and contusions. Review of published literature on topical nonsteroidal anti-inflammatory drugs (NSAIDs, diclofenac, and DETP in patients with acute soft tissue injuries was included. Relevant literature was identified on MEDLINE using the search terms topical NSAIDs, diclofenac, diclofenac epolamine, acute pain, sports injury, soft tissue injury, strain, sprain, and contusion, and from citations in retrieved articles covering the years 1978–2008. Review of published, randomized clinical trials and meta-analyses shows that topical NSAIDs are significantly more effective than placebo in relieving acute pain; the pooled average relative benefit was 1.7 (95% confidence interval, 1.5–1.9. In a limited number of comparisons, topical and oral NSAIDs provided comparable pain relief, but the use of topical agents produced lower plasma drug concentrations and fewer systemic adverse events (AEs. The physical–chemical properties of diclofenac epolamine make it well suited for topical use. In patients with acute soft tissue injuries treated with DETP, clinical data report an analgesic benefit within hours of the first application, and significant pain relief relative to placebo within 3 days. Moreover, DETP displayed tolerability comparable with placebo; the most common AEs were pruritus and other application site reactions. Review of published literature suggests that DETP is generally safe and well tolerated, clinically efficacious, and a rational treatment option for patients experiencing acute pain associated with strains, sprains, and contusions, and other localized painful conditions

75 FR 26647 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

Science.gov (United States)

2010-05-12

.... FDA-2010-N-0002] Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution... are treated with a topical solution of ivermectin. DATES: This rule is effective May 12, 2010. FOR... ANADA 200-340 for PRIVERMECTIN (ivermectin), a topical solution used on cattle to control infestations...

Women's Health Topics

Science.gov (United States)

... Information by Audience For Women Women's Health Topics Women's Health Topics Share Tweet Linkedin Pin it More sharing options Linkedin Pin it Email Print National Women's Health Week May 13 - 19, 2018 Join us ...

Learning Tools for Knowledge Nomads: Using Personal Digital Assistants (PDAs) in Web-based Learning Environments.

Science.gov (United States)

Loh, Christian Sebastian

2001-01-01

Examines how mobile computers, or personal digital assistants (PDAs), can be used in a Web-based learning environment. Topics include wireless networks on college campuses; online learning; Web-based learning technologies; synchronous and asynchronous communication via the Web; content resources; Web connections; and collaborative learning. (LRW)

Health and environment: social science perspectives

NARCIS (Netherlands)

Kopnina, H.; Keune, H.

2010-01-01

In this new book the authors examine the contribution of social scientists to the topics of health and environment. They present diverse perspectives on classical and contemporary debates by focusing on social scientific framing of environment and health, as well as on the potential contribution of

Discrepancies between parent and adolescent beliefs about daily life topics and performance on an emotion recognition task.

Science.gov (United States)

De Los Reyes, Andres; Lerner, Matthew D; Thomas, Sarah A; Daruwala, Samantha; Goepel, Katherine

2013-08-01

Parents and children and adolescents commonly disagree in their perceptions of a variety of behaviors, including the family relationship and environment, and child and adolescent psychopathology. To this end, numerous studies have examined to what extent increased discrepant perceptions-particularly with regard to perceptions of the family relationship and environment-predict increased child and adolescent psychopathology. Parents' and children and adolescents' abilities to decode and identify others' emotions (i.e., emotion recognition) may play a role in the link between discrepant perceptions and child and adolescent psychopathology. We examined parents' and adolescents' emotion recognition abilities in relation to discrepancies between parent and adolescent perceptions of daily life topics. In a sample of 50 parents and adolescents ages 14-to-17 years (M = 15.4 years, 20 males, 54 % African-American), parents and adolescents were each administered a widely used performance-based measure of emotion recognition. Parents and adolescents were also administered a structured interview designed to directly assess each of their perceptions of the extent to which discrepancies existed in their beliefs about daily life topics (e.g., whether adolescents should complete their homework and carry out household chores). Interestingly, lower parent and adolescent emotion recognition performance significantly related to greater parent and adolescent perceived discrepant beliefs about daily life topics. We observed this relation whilst accounting for adolescent age and gender and levels of parent-adolescent conflict. These findings have important implications for understanding and using informant discrepancies in both basic developmental psychopathology research and applied research in clinic settings (e.g., discrepant views on therapeutic goals).

How the Physical Work Environment Can Affect Individual Productivity

OpenAIRE

Johannsdottir, Thordis; Hansen, Rebecca

2017-01-01

Master's thesis in Strategic Management The topic of this thesis is about how the physical work environment affects individual productivity, and with focus on productivity through the well-being aspect of individuals. The thesis has a theoretical approach with a pilot-exercise including a pilot experiment and questionnaire. This approach was chosen as the research question is comprehensive, and with the timeframe to complete this thesis. A theoretical approach gives the possibility to furt...

Retail food environments research in Canada: A scoping review.

Science.gov (United States)

Minaker, Leia M; Shuh, Alanna; Olstad, Dana L; Engler-Stringer, Rachel; Black, Jennifer L; Mah, Catherine L

2016-06-09

The field of retail food environments research is relatively new in Canada. The objective of this scoping review is to provide an overview of retail food environments research conducted before July 2015 in Canada. Specifically, this review describes research foci and key findings, identifies knowledge gaps and suggests future directions for research. A search of published literature concerning Canadian investigations of retail food environment settings (food stores, restaurants) was conducted in July 2015 using PubMed, Web of Science, Scopus, PsychInfo and ERIC. Studies published in English that reported qualitative or quantitative data on any aspect of the retail food environment were included, as were conceptual papers and commentaries. Eighty-eight studies were included in this review and suggest that the field of retail food environments research is rapidly expanding in Canada. While only 1 paper was published before 2005, 66 papers were published between 2010 and 2015. Canadian food environments research typically assessed either the socio-economic patterning of food environments (n = 28) or associations between retail food environments and diet, anthropometric or health outcomes (n = 33). Other papers profiled methodological research, qualitative studies, intervention research and critical commentaries (n = 27). Key gaps in the current literature include measurement inconsistency among studies and a lack of longitudinal and intervention studies. Retail food environments are a growing topic of research, policy and program development in Canada. Consistent methods (where appropriate), longitudinal and intervention research, and close partnerships between researchers and key stakeholders would greatly advance the field of retail food environments research in Canada.

Quark-gluon plasma (Selected Topics)

International Nuclear Information System (INIS)

Zakharov, V. I.

2012-01-01

Introductory lectures to the theory of (strongly interacting) quark-gluon plasma given at the Winter School of Physics of ITEP (Moscow, February 2010). We emphasize theoretical issues highlighted by the discovery of the low viscosity of the plasma. The topics include relativistic hydrodynamics, manifestations of chiral anomaly in hydrodynamics, superfluidity, relativistic superfluid hydrodynamics, effective stringy scalars, holographic models of Yang-Mills theories.

Human-competitive automatic topic indexing

CERN Document Server

Medelyan, Olena

2009-01-01

Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

Selected topics from classical bacterial genetics.

Science.gov (United States)

Raleigh, Elisabeth A; Elbing, Karen; Brent, Roger

2002-08-01

Current cloning technology exploits many facts learned from classical bacterial genetics. This unit covers those that are critical to understanding the techniques described in this book. Topics include antibiotics, the LAC operon, the F factor, nonsense suppressors, genetic markers, genotype and phenotype, DNA restriction, modification and methylation and recombination.

Context updating during sentence comprehension: the effect of aboutness topic.

Science.gov (United States)

Burmester, Juliane; Spalek, Katharina; Wartenburger, Isabell

2014-10-01

To communicate efficiently, speakers typically link their utterances to the discourse environment and adapt their utterances to the listener's discourse representation. Information structure describes how linguistic information is packaged within a discourse to optimize information transfer. The present study investigates the nature and time course of context integration (i.e., aboutness topic vs. neutral context) on the comprehension of German declarative sentences with either subject-before-object (SO) or object-before-subject (OS) word order using offline comprehensibility judgments and online event-related potentials (ERPs). Comprehensibility judgments revealed that the topic context selectively facilitated comprehension of stories containing OS (i.e., non-canonical) sentences. In the ERPs, the topic context effect was reflected in a less pronounced late positivity at the sentence-initial object. In line with the Syntax-Discourse Model, we argue that these context-induced effects are attributable to reduced processing costs for updating the current discourse model. The results support recent approaches of neurocognitive models of discourse processing. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Topical therapy for facial allergic dermatoses

Directory of Open Access Journals (Sweden)

Y. S. Kondratyeva

2015-01-01

Full Text Available The research goal is to assess clinical dynamics and morphofunctional skin parameters of patients with facial allergic dermatoses on the background of combined topical therapy. Materials and methods. 45 patients with various facial allergic dermatoses in dry and sensitive skin took part in the research. The methods included anamnesis taking, poll, objective examination and assessment of morphofunctional parameters of skin, as well as estimation of life quality dynamic index (LQDI. Main results. After a course of treatment with 0,05% solution of alclometasone dipropionate inflammation of dermatosis ceased in 45 (100% patients, itching and pains in 39 (86,7% patients, but complaints about dryness and peeling of facial skin remained in 41 (91,1% and 40 (88,8% patients respectively. On the background of therapy including emollient Aflocream the above mentioned symptoms did not appear in 43 (95,6% patients, wherein maximum effect was achieved in patients with allergic contact dermatitis - 14 (93,3%. After a course of topical therapy all patients showed statistically significant increase of epidermal moisture level, alongside with reduction of skin relief and degree of keratinization. During the assessment of LQDI a tendency to reduction of proportion of patients on whom the disease has a strong and extremely strong impact was noted in 10 patients (i.e. 22,2%, moderate influence - in 5 of them (11,45%, insignificant influence or its absence - in 30 (66,7% people. Conclusion. Combined therapy including the use of a topical corticosteroid Afloderm and an emollient Aflocream showed good clinical efficiency in patients with facial allergic dermatoses. The efficiency is also confirmed with improvements in morphofunctional characteristics of patients’ skin on the background of therapy.

Topics in computational linear optimization

DEFF Research Database (Denmark)

Hultberg, Tim Helge

2000-01-01

Linear optimization has been an active area of research ever since the pioneering work of G. Dantzig more than 50 years ago. This research has produced a long sequence of practical as well as theoretical improvements of the solution techniques avilable for solving linear optimization problems...... of high quality solvers and the use of algebraic modelling systems to handle the communication between the modeller and the solver. This dissertation features four topics in computational linear optimization: A) automatic reformulation of mixed 0/1 linear programs, B) direct solution of sparse unsymmetric...... systems of linear equations, C) reduction of linear programs and D) integration of algebraic modelling of linear optimization problems in C++. Each of these topics is treated in a separate paper included in this dissertation. The efficiency of solving mixed 0-1 linear programs by linear programming based...

A system of UAV application in indoor environment

DEFF Research Database (Denmark)

Khosiawan, Yohanes; Nielsen, Izabela Ewa

2016-01-01

In recent years, there has been an increased demand in the use of multiple unmanned aerial vehicles (UAVs) in indoor environments such as material handling task in a manufacturing environment and plant/environment monitoring task in a greenhouse. However, there is a lack of work reported on this ......In recent years, there has been an increased demand in the use of multiple unmanned aerial vehicles (UAVs) in indoor environments such as material handling task in a manufacturing environment and plant/environment monitoring task in a greenhouse. However, there is a lack of work reported...... on this topic. This paper presents a detailed study on several UAV systems and UAV scheduling systems. It is followed by a proposed system of UAV application in indoor environment, which comprises components of UAV system addressed in detail; focused on scheduler as the heart of operations. Consequently, system...... architecture of UAV scheduling system is presented and the framework of scheduler component is included. Scheduler component works in a phased manner to provide a systematic abstraction and achieve an efficient computation time. This study serves as a reference guide for UAV application in indoor environment....

Topic Visualization and Survival Analysis

OpenAIRE

Wang, Ping Jr

2017-01-01

Latent semantic structure in a text collection is called a topic. In this thesis, we aim to visualize topics in the scientific literature and detect active or inactive research areas based on their lifetime. Topics were extracted from over 1 million abstracts from the arXiv.org database using Latent Dirichlet Allocation (LDA). Hellinger distance measures similarity between two topics. Topics are determined to be relevant if their pairwise distances are smaller than the threshold of Hellinger ...

Efficacy, tolerability and consumer acceptability of terbinafine topical spray versus terbinafine topical solution: a phase IIa, randomised, observer-blind, comparative study.

Science.gov (United States)

Brown, Marc; Evans, Charles; Muddle, Andrew; Turner, Rob; Lim, Sian; Reed, Jessica; Traynor, Matt

2013-10-01

Tinea pedis is one of the world's most prevalent dermatophyte infections. MedSpray™ tinea pedis 1 % w/w (topical spray) is a novel, easy-to-use propellant-based spray formulation containing 1 % w/w terbinafine, requiring no manipulation at the site of infection. This is in contrast to the only formulation currently approved in Europe for single application (none are approved in the USA for single use), which is Lamisil(®) Once 1 % w/w (topical solution), containing 1 % w/w terbinafine hydrochloride, which requires manipulation on the affected area. The aim of this study was to evaluate the efficacy, tolerability and consumer acceptability of a topical spray versus a topical solution in the treatment of tinea pedis. This study is a phase IIa, randomised, observer-blind, non-inferiority comparative study of the topical spray compared with the topical solution over a 12-week study period. The study was conducted at Bioskin GmbH, Hamburg and Berlin. Patients (n = 120) who presented with the presence of interdigital tinea pedis caused by dermatophytes on one or both feet were enrolled in the study. Patients were randomly assigned between the two treatment groups. Either the topical spray or the topical solution was administered by the study nurse and consisted of a single application (equivalent to 20 mg of terbinafine per foot) on day 1 of the study. No further applications were made for the duration of the study. The hypothesis formulated before commencement of the study was that the topical spray would prove to be non-inferior to the topical solution. Efficacy assessments, including clinical signs and symptoms, mycology and microscopy were performed at baseline and 1, 6 and 12 weeks after treatment. The rate of mycological cure at week 1 was statistically equivalent for both treatments. There was a significant reduction in the overall clinical score as assessed by the Physician's Global Assessment of signs and symptoms for both treatment groups. The topical

GeneTopics - interpretation of gene sets via literature-driven topic models

Science.gov (United States)

2013-01-01

Background Annotation of a set of genes is often accomplished through comparison to a library of labelled gene sets such as biological processes or canonical pathways. However, this approach might fail if the employed libraries are not up to date with the latest research, don't capture relevant biological themes or are curated at a different level of granularity than is required to appropriately analyze the input gene set. At the same time, the vast biomedical literature offers an unstructured repository of the latest research findings that can be tapped to provide thematic sub-groupings for any input gene set. Methods Our proposed method relies on a gene-specific text corpus and extracts commonalities between documents in an unsupervised manner using a topic model approach. We automatically determine the number of topics summarizing the corpus and calculate a gene relevancy score for each topic allowing us to eliminate non-specific topics. As a result we obtain a set of literature topics in which each topic is associated with a subset of the input genes providing directly interpretable keywords and corresponding documents for literature research. Results We validate our method based on labelled gene sets from the KEGG metabolic pathway collection and the genetic association database (GAD) and show that the approach is able to detect topics consistent with the labelled annotation. Furthermore, we discuss the results on three different types of experimentally derived gene sets, (1) differentially expressed genes from a cardiac hypertrophy experiment in mice, (2) altered transcript abundance in human pancreatic beta cells, and (3) genes implicated by GWA studies to be associated with metabolite levels in a healthy population. In all three cases, we are able to replicate findings from the original papers in a quick and semi-automated manner. Conclusions Our approach provides a novel way of automatically generating meaningful annotations for gene sets that are directly

Effects of solar electromagnetic radiation on the terrestrial environment

International Nuclear Information System (INIS)

Dickinson, R.E.

1986-01-01

The general intent of this essay is to discuss the effect of solar electromagnetic radiation on the terrestrial environment. Instead of giving a systematic approach considering all environment processes where solar emission is the primary energy source and all important materials which have been generated by solar driven processes, the author sketches an impression of the range of the effects of solar radiation on the environment by surveying a number of topics of particular current interest, in varying levels of detail. These include atmospheric chemistry, some aspects of the transfer of radiation within the atmosphere, global energy balance and climate feedbacks, especially those due to clouds, impacts of fossil fuel energy use, evolution of early life processes, photosynthesis and plant productivity as it relates to photosynthesis and the global carbon cycle. (Auth.)

The role of quantum information in thermodynamics—a topical review

International Nuclear Information System (INIS)

Goold, John; Huber, Marcus; Riera, Arnau; Skrzypczyk, Paul; Rio, Lídia del

2016-01-01

This topical review article gives an overview of the interplay between quantum information theory and thermodynamics of quantum systems. We focus on several trending topics including the foundations of statistical mechanics, resource theories, entanglement in thermodynamic settings, fluctuation theorems and thermal machines. This is not a comprehensive review of the diverse field of quantum thermodynamics; rather, it is a convenient entry point for the thermo-curious information theorist. Furthermore this review should facilitate the unification and understanding of different interdisciplinary approaches emerging in research groups around the world. (topical review)

Radiological protection of the environment, including non-human species-views from the global nuclear industry

International Nuclear Information System (INIS)

Saint-Pierre, S.; RPWG

2008-01-01

This paper updates the WNA key messages on the RP of the environment. This paper shows that the chronology of views (2000-2008) leads to a recognition that the current RP system has provided adequate protection of people and of the environment. In early 2000s, doubts were raised on the adequacy of the RP system. Next (2002-2005), the international community forged the view that the current RP system has in practice provided appropriate standards of environmental protection, but also acknowledged that the system needs further development to fill a 'conceptual gap'. In 2005, the IAEA plan of activities on the RP of the environment formalized international developments and conditioned the future revision (if any) of current standards. During 2006-2008, ICRP issued new guidance on RP of non-human species which offers little on an assessment framework of practical use and on a compelling case for such assessments. This guidance, based on the new ICRP concept of Reference Animals and Plants, falls short in terms of environmental protection approach. A milestone study on the RP of non-human species is the SENES independent overview (2007) which 'confirmed that both people and nature have been adequately protected from radioactive releases from all kinds of nuclear sites, old and new'. This overview covers case studies for nuclear sites including some that had experienced major accidents. It derives that the earlier acknowledgement on the 'conceptual gap' appears no longer valid or at the very least, that the gap (if any) is extremely small. The RP of the environment is part of the on-going revision of the current IAEA Basic Safety Standards (BSS). We emphasize that the recently published BSS draft 1.0 in July 2008 covers (with adequacy) RP of the environment through general provisions (free of provisions to non-human species) on the assessment of environmental impact. (author)

Topical and transdermal drug delivery: principles and practice

National Research Council Canada - National Science Library

Benson, Heather A. E; Watkinson, Adam C

2012-01-01

.... Providing an overview of the current science in drug and cosmetic application to and through the skin, Topical and Transdermal Drug Delivery includes treatment of skin conditions, skin permeation...

Theory of the talkative action and the environment

International Nuclear Information System (INIS)

Aguirre Munoz, Alfonso

1997-01-01

This essay treat about the theory of the talkative action of Jurgen Habermas (1987), with relationship to the environment, to explore its bonds and to try to associate them to the perception and the current attitudes on the ecological topic. The positions are revised by the own Habermas (1993), as answer to the comments of several authors, and to elaborate freely, referring them when it is pertinent. A summary is made on the fundamental concepts, to my to understand, of the theory of the talkative action. The excellent elements of Habermas are revised for a discussion on the environmental particular topic. At the end it is tried to make an original discussion, integrating as central axis of the Habermas positions, at the same time of others authors related with the environment topic

Topical Session on the Decommissioning and Dismantling Safety Case

International Nuclear Information System (INIS)

2002-01-01

Set up by the Radioactive Waste Management Committee (RWMC), the WPDD brings together senior representatives of national organisations who have a broad overview of Decommissioning and Dismantling (D and D) issues through their work as regulators, implementers, R and D experts or policy makers. These include representatives from regulatory authorities, industrial decommissioners from the NEA Cooperative Programme on Exchange of Scientific and Technical Information on Nuclear Installation Decommissioning Projects (CPD), and cross-representation from the NEA Committee on Nuclear Regulatory Activities, the Committee on Radiation Protection and Public Health, and the RWMC. The EC is a member of the WPDD and the IAEA also participates. This ensures co-ordination amongst activities in these international programmes. Participation from civil society organisations is considered on a case by case basis, and has already taken place through the active involvement of the Group of Municipalities with Nuclear Installations at the first meeting of the WPDD At its second meeting, in Paris, 5-7 December 2001, the WPDD held two topical sessions on the D and D Safety Case and on the Management of Materials from D and D, respectively. This report documents the topical session on the safety case. The topical session was meant to provide an exchange of information and experience on the following issues: What topics should be included in a safety case? Of what should it consist? Is there sufficient and complete guidance nationally and internationally? How do practices differ internationally? Main boundary condition to this session was that it would deal with plants where spent fuel has been removed. Also the topical sessions was kept at a level that makes the most of the varied constituency of the WPDD. Namely, interface issues are important, and issue-identification and discussion was the immediate goal. There was less interest in examining areas where variability amongst national

Topical review of the Finnish forest sector 1996

International Nuclear Information System (INIS)

Kuuluvainen, K.

1996-01-01

The present report is e review of the Finnish forest sector, made by several authors. The topics reviewed are: Economic trends of forest sector; The operational conditions of the forest sector; Development of the forest sector; Conjuncture reviews; Special topics including the certification of the forests, the forest reserves in Finland, the financial support forest economy, export prices of sawn timber and cellulose, raw-wood markets, forests and forest industry shares as targets for investments, recreational use of the state owned areas. (8 refs.)

Elephant logging and environment

International Nuclear Information System (INIS)

Tin-Aung-Hla

1995-01-01

The natural environment comprises non-biological elements such as air, water, light, heat and biological elements of animal and plant life; all interact with each other to create an ecosystem. Human activities like over-exploitation of forest results in deforestation and desertification. This consequently changes ecological balance. Topics on: (1) history of elephants utilization; (2) elephant logging; (3) classification of elephants; (4) dragging gear; (5) elephant power; (6) elephant logging and environment, are discussed

Natural radiation environment

International Nuclear Information System (INIS)

Vohra, K.G.; Mishra, U.C.; Pillai, K.C.; Sadasivan, S.

1982-01-01

The volume presented contains papers presented at the Second Special Symposium on Natural Radiation Environment held at Bombay, India, during January 1981. The papers deal with such topics as : 1)high natural radiation background areas; 2)environmental natural radioactivity; 3)measurement techniques; 4)technologically enhanced radioactivity; 5)indoor radiation environment; 6)radon and daughters in ambient air, and 7)applications in Geosciences. Each of the 87 papers presented has been abstracted and indexed for the U.S. Department of Energy Technical Information Center's Energy Data Base

[Environmental behavior of graphene and its effect on the transport and fate of pollutants in environment].

Science.gov (United States)

Ren, Wen-Jie; Teng, Ying

2014-09-01

Graphene is one of the most popular research topics in carbon nanomaterials. Because of its special physical and chemical properties, graphene will have wide applications. As the production and application amount is increasing, graphene will be inevitably released to the environment, resulting in risks of ecological environment and human health. It is of very vital significance for evaluating environmental risks of graphene scientifically and objectively to understand its environmental behavior and fate and explore its effect on the environmental behaviors of pollutants. This paper reviewed the environmental behavior of graphene, such as colloid properties and its stability in the aqueous environment and its transport through porous media. Additionally, the paper reviewed the effect of graphene on the transport and fate of pollutants. The interactions between graphene and heavy metals or organic compounds were especially discussed. Important topics should be explored including sorption mechanisms, interactions between graphene and soil components, influence of graphene on the transport and bioavailability of pollutants in environment, as well as approaches to quantifying graphene. The review might identify potential new ideas for further research in applications of graphene.

Natural radiation environment III

International Nuclear Information System (INIS)

Gesell, T.F.; Lowder, W.M.

1980-01-01

Separate abstracts were prepared for the 52 research papers presented at this symposium in April 1978. The major topics in this volume deal with penetrating radiation measurements, radiation surveys and population exposure, radioactivity in the indoor environment, and technologically enhanced natural radioactivity

Topical ganciclovir in the treatment of acute herpetic keratitis.

Science.gov (United States)

Tabbara, Khalid F; Al Balushi, Noorjehan

2010-08-19

Herpetic keratitis is caused by herpes simplex virus (HSV) and is a common cause of corneal blindness. Following a primary ocular herpetic infection, latency of the virus occurs, followed by subsequent recurrences of herpetic keratitis. Such recurrences may lead to structural damage of the cornea. Recurrent herpetic keratitis is a common indication for corneal transplantation. Recurrences of herpetic keratitis in the corneal graft may lead to corneal graft rejection. Several antiviral agents for HSV are available, including the thymidine analogs. Prolonged use of thymidine analogs may lead to toxicity of the ocular surface, including epithelial keratitis, corneal ulcers, follicular conjunctivitis, and punctal occlusions. Availability of topical antiviral agents that are safe and effective in the treatment and prophylaxis of herpetic keratitis is highly desirable. Ganciclovir is a potent inhibitor of members of the herpes virus family. The drug has been used systemically for the treatment of cytomegalovirus (CMV) retinitis. Its hematologic toxicity secondary to systemic administration led to its limited use in herpetic infections. On the other hand, topical ganciclovir has been shown to be as safe and effective as acyclovir in the treatment of herpetic epithelial keratitis. Furthermore, topical ganciclovir can reach therapeutic levels in the cornea and aqueous humor following topical application. Several clinical trials have shown that topical ganciclovir 0.15% ophthalmic gel is safe and effective in the treatment and prophylaxis of herpetic epithelial disease. Long-term use of ganciclovir ophthalmic gel in patients with penetrating keratoplasty following herpetic keratitis has prevented recurrences of the disease. Topical ganciclovir ophthalmic gel is well tolerated, does not cause toxic effects on the ocular surface, and does not cause hematologic abnormalities. Clinical studies have underscored the potential role of ganciclovir ophthalmic gel in the treatment and

Properties of structural materials in liquid metal environment

International Nuclear Information System (INIS)

Borgstedt, H.U.

1991-12-01

The proceedings contain 16 contributions to the following topics: 1. Creep-Rupture Behaviour of Structural Materials in Liquid Metal Environment; 2. Behaviour of Materials in Liquid Metal Environment under Off-Normal Conditions; 3. Fatigue and Creep-Fatigue of Structural Materials in Liquid Metal Environment; and 4. Crack Propagation in Liquid Sodium. (MM)

Incorporating Topic Assignment Constraint and Topic Correlation Limitation into Clinical Goal Discovering for Clinical Pathway Mining

Directory of Open Access Journals (Sweden)

Xiao Xu

2017-01-01

Full Text Available Clinical pathways are widely used around the world for providing quality medical treatment and controlling healthcare cost. However, the expert-designed clinical pathways can hardly deal with the variances among hospitals and patients. It calls for more dynamic and adaptive process, which is derived from various clinical data. Topic-based clinical pathway mining is an effective approach to discover a concise process model. Through this approach, the latent topics found by latent Dirichlet allocation (LDA represent the clinical goals. And process mining methods are used to extract the temporal relations between these topics. However, the topic quality is usually not desirable due to the low performance of the LDA in clinical data. In this paper, we incorporate topic assignment constraint and topic correlation limitation into the LDA to enhance the ability of discovering high-quality topics. Two real-world datasets are used to evaluate the proposed method. The results show that the topics discovered by our method are with higher coherence, informativeness, and coverage than the original LDA. These quality topics are suitable to represent the clinical goals. Also, we illustrate that our method is effective in generating a comprehensive topic-based clinical pathway model.

Preservice Teachers' Perspectives on 'Appropriate' K-8 Climate Change and Environmental Science Topics

Science.gov (United States)

Ford, D. J.

2013-12-01

With the release of the Next Generation Science Standards (NRC, 2013), climate change and related environmental sciences will now receive greater emphasis within science curricula at all grade levels. In grades K-8, preparation in foundational content (e.g., weather and climate, natural resources, and human impacts on the environment) and the nature of scientific inquiry will set the groundwork for later learning of climate change in upper middle and high school. These rigorous standards increase pressure on elementary and middle school teachers to possess strong science content knowledge, as well as experience supporting children to develop scientific ideas through the practices of science. It also requires a set of beliefs - about children and the science that is appropriate for them - that is compatible with the goals set out in the standards. Elementary teachers in particular, who often have minimal preparation in the earth sciences (NSF, 2007), and entrenched beliefs about how particular topics ought to be taught (Holt- Reynolds, 1992; Pajares, 1992), including climate change (Bryce & Day, 2013; Lambert & Bleicher, 2013), may face unique challenges in adjusting to the new standards. If teachers hold beliefs about climate change as controversial, for example, they may not consider it an appropriate topic for children, despite its inclusion in the standards. On the other hand, those who see a role for children in efforts to mitigate human impacts on the environment may be more enthusiastic about the new standards. We report on a survey of preservice K-8 teachers' beliefs about the earth and environmental science topics that they consider to be appropriate and inappropriate for children in grades K-3, 4-5, and 6-8. Participants were surveyed on a variety of standards-based topics using terminology that signals publicly and scientifically neutral (e.g. weather, ecosystems) to overtly controversial (evolution, global warming) science. Results from pilot data

Panel discussion: Which severe accident chemistry topics most deserve further research?

International Nuclear Information System (INIS)

Bergeron, K.D.

1988-01-01

A severe accident would involve so many species and chemical environments within the plant that detailed description of all the chemical reactions and chemistry-related processes is currently not practical or even possible. Thus it is necessary to select for consideration those phenomena which might be most important. The panel will discuss which severe accident chemistry topics most deserve further research

Solid-State Lighting 2017 Suggested Research Topics

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-09-29

A 2017 update to the Solid-State Lighting R&D Plan that is divided into two documents. The first document describes a list of suggested SSL priority research topics and the second document provides context and background, including information drawn from technical, market, and economic studies. Widely referenced by industry and government both here and abroad, these documents reflect SSL stakeholder inputs on key R&D topics that will improve efficacy, reduce cost, remove barriers to adoption, and add value for LED and OLED lighting solutions over the next three to five years, and discuss those applications that drive and prioritize the specific R&D.

Environment and Medical Sciences Division Progress Report

International Nuclear Information System (INIS)

Hainge, W.M.

1980-06-01

The 1979 annual progress report of the UKAEA Environmental and Medical Sciences Division covers both radiological and non-nuclear research programmes in the environmental and toxicological fields. The specific topics were 1) 'atmospheric pollution' which included the analysis of atmospheric trace gases by gas chromatography/mass spectrometry, the life cycle of atmospheric sulphur compounds, photochemical pollution, studies on stratospheric reactions, stratospheric ozone and the effects of pollutants, upper air sampling and monitoring gaseous atmospheric pollutants with passive samplers; 2) miscellaneous 'environmental safety projects'; 3) 'radiation physics' projects concerning a) radioactive fallout, b) studies of stable trace elements in the atmospheric environment and studies of radioactivity in the environment, c) various aspects of dosimetry research including radiation biophysics, d) personnel dosimetry, e) applied radiation spectrometry and f) data systems; 5) 'aerosol and metabolic studies' including whole body counting studies; 6) 'inhalation toxicology and radionuclide analysis' studies including actinide inhalation, cytotoxicity and fibrogenicity of non-radioactive dusts, asbestos and glass fibre research, a Qauntimet 720 image analysis service and radionuclide analysis in biological materials; and 7) 'analytical services' used in relation to 'environmental safety and chemical analysis' projects. (U.K.)

"You're Moving a Frickin' Big Ship": The Challenges of Addressing LGBTQ Topics in Public Schools

Science.gov (United States)

Fredman, Amy J.; Schultz, Nicole J.; Hoffman, Mary F.

2015-01-01

Scholars have become more attentive to lesbian/gay/bisexual/transsexual/queer/questioning (LGBTQ) topics as queer perspectives become increasingly prevalent in middle and high school environments. This study examines how educators navigate social and academic environments in order to incorporate inclusive pedagogical practices and cultivate safe…

Health Topic XML File Description

Science.gov (United States)

... this page: https://medlineplus.gov/xmldescription.html Health Topic XML File Description: MedlinePlus To use the sharing ... information categories assigned. Example of a Full Health Topic Record A record for a MedlinePlus health topic ...

Topical medication instillation techniques for glaucoma.

Science.gov (United States)

Xu, Li; Wang, Xuemei; Wu, Meijing

2017-02-20

Glaucoma is a leading cause of irreversible blindness worldwide and the second most common cause of blindness after cataracts. The primary treatment for glaucoma aims to lower intraocular pressure (IOP) with the use of topical medicines. Topical medication instillation techniques, such as eyelid closure and nasolacrimal occlusion when instilling drops, have been proposed as potential methods to increase ocular absorption and decrease systemic absorption of the drops. To investigate the effectiveness of topical medication instillation techniques compared with usual care or another method of instillation of topical medication in the management of glaucoma or ocular hypertension. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 12), MEDLINE Ovid (1946 to 8 December 2016), Embase Ovid (1947 to 8 December 2016), PubMed (1948 to 8 December 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 8 December 2016), International Pharmaceutical Abstracts Database (1970 to 8 December 2016), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched 13 May 2013), ClinicalTrials.gov (www.clinicaltrials.gov) (searched 8 December 2016) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en) (searched 8 December 2016). We did not use any date or language restrictions in the electronic searches for trials. We included randomized controlled trials which had compared any topical medication instillation technique with usual care or a different method of instillation of topical medication. Two review authors independently screened records from the searches for eligibility, assessed the risk of bias, and extracted data. We followed methods recommended by Cochrane. We identified two trials (122 eyes of 61 participants) that had evaluated a topical medication instillation technique. We

Canadian Environments: Essays in Culture, Politics and History

DEFF Research Database (Denmark)

Responding to the comprehensive topic 'Old Environments - New Environments', scholars from a variety of disciplines reflect the various connotations that the term 'environment' carries in a Canadian context. Whether moving within the realm of foreign policy, visual arts, constitutional questions...

Pavement-Watering for Cooling the Built Environment: A Review

OpenAIRE

Hendel , Martin

2016-01-01

Pavement-watering is being considered by decision-makers in many cities as a means of cooling the built environment and of adapting to rising extreme heat events due to climate change. In this article we review the existing literature on the topic of pavement-watering. We first focus on the methodological choices made in the literature, including study approach and scale, watering methods used as well as how results are analyzed. We then discuss the cooling effects reported, separating micro-...

Selected papers on analysis and related topics

CERN Document Server

2008-01-01

This volume contains translations of papers that originally appeared in the Japanese journal Sūgaku. The papers range over a variety of topics, including operator algebras, analysis, and statistics. This volume is suitable for graduate students and research mathematicians interested in analysis and its applications.

Topics in Finance: Part II--Financial Analysis

Science.gov (United States)

Laux, Judy

2010-01-01

The second article in a series designed to supplement the introductory financial management course, this essay addresses financial statement analysis, including its impact on stock valuation, disclosure, and managerial behavior. [For "Topics in Finance Part I--Introduction and Stockholder Wealth Maximization," see EJ1060345.

Including the Consumer and Environment in Occupational Therapy Treatment Planning.

Science.gov (United States)

Brown, Catana; Bowen, Robin E.

1998-01-01

Occupational therapists (n=29) completed treatment plans based on case study data. Analysis indicated they often identified goals not addressed by the consumer/client. They significantly selected more simulated than real activities and more activities designed to change the person rather than the environment. (SK)

Identifying Topics in Microblogs Using Wikipedia.

Science.gov (United States)

Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

2016-01-01

Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

Hot Topics/New Initiatives | Drinking Water in New England ...

Science.gov (United States)

2017-07-06

Information on Drinking Water in New England. Major Topics covered include: Conservation, Private Wells, Preventing Contamination, Drinking Water Sources, Consumer Confidence Reports, and Drinking Water Awards.

Adaptive Dialogue Systems for Assistive Living Environments

Science.gov (United States)

Papangelis, Alexandros

2013-01-01

Adaptive Dialogue Systems (ADS) are intelligent systems, able to interact with users via multiple modalities, such as speech, gestures, facial expressions and others. Such systems are able to make conversation with their users, usually on a specific, narrow topic. Assistive Living Environments are environments where the users are by definition not…

Identifying Topics in Microblogs Using Wikipedia.

Directory of Open Access Journals (Sweden)

Ahmet Yıldırım

Full Text Available Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA, propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision and other observations from the study are discussed in detail.

Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

International Nuclear Information System (INIS)

Nguyen, H T P; Munnier, E; Souce, M; Perse, X; David, S; Bonnier, F; Cohen-Jonathan, S; Chourpa, I; Vial, F; Yvergnaux, F; Perrier, T

2015-01-01

The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients with chronic skin disease. The aim of this work is to design a novel nanocarrier of hydrophobic active molecules and to determine its potential as an ingredient of a topical form. The nanocarrier consists of an oily core surrounded by a protective shell of alginate, a natural polysaccharide isolated from brown algae. These calcium alginate-based nanocarriers (CaANCs) were prepared at room temperature and without the use of organic solvent by an accelerated nanoemulsification-polymer crosslinking method. The size (hydrodynamic diameter ∼200 nm) and surface charge (zeta potential ∼ − 30 mV) of the CaANCs are both compatible with their application on skin. CaANCs loaded with a fluorescent label were stable in model hydrophilic galenic forms under different storage conditions. Curcumin was encapsulated in CaANCs with an efficiency of ∼95%, fully retaining its antioxidant activity. The application of the curcumin-loaded CaANCs on excised human skin led to a significant accumulation of the active molecules in the upper layers of the skin, asserting the potential of these nanocarriers in active pharmaceutical and cosmetic ingredients topical delivery. (paper)

Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

Science.gov (United States)

Nguyen, H. T. P.; Munnier, E.; Souce, M.; Perse, X.; David, S.; Bonnier, F.; Vial, F.; Yvergnaux, F.; Perrier, T.; Cohen-Jonathan, S.; Chourpa, I.

2015-06-01

The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients with chronic skin disease. The aim of this work is to design a novel nanocarrier of hydrophobic active molecules and to determine its potential as an ingredient of a topical form. The nanocarrier consists of an oily core surrounded by a protective shell of alginate, a natural polysaccharide isolated from brown algae. These calcium alginate-based nanocarriers (CaANCs) were prepared at room temperature and without the use of organic solvent by an accelerated nanoemulsification-polymer crosslinking method. The size (hydrodynamic diameter ˜200 nm) and surface charge (zeta potential ˜ - 30 mV) of the CaANCs are both compatible with their application on skin. CaANCs loaded with a fluorescent label were stable in model hydrophilic galenic forms under different storage conditions. Curcumin was encapsulated in CaANCs with an efficiency of ˜95%, fully retaining its antioxidant activity. The application of the curcumin-loaded CaANCs on excised human skin led to a significant accumulation of the active molecules in the upper layers of the skin, asserting the potential of these nanocarriers in active pharmaceutical and cosmetic ingredients topical delivery.

Using Technology to Support Discussions on Sensitive Topics in the Study of Business Ethics

Directory of Open Access Journals (Sweden)

Michelle WL Fong

2015-06-01

Full Text Available There is a dearth of research into teaching strategies and learning approaches for units involving sensitive topics that can provoke an emotional response in students. In a business ethics unit, attempts to strike a balance between conceptual knowledge and theory and skills training can be challenging because the unit can involve personal, sensitive or controversial topics. When engaging in deep and meaningful face-to-face discussion, students may unknowingly divulge personal opinions that they later regret or become identified with by other students over time. Value-laden topics may also lead to clashes between students if face-to-face discussions are not managed properly. This paper considers the use of technology in blended learning to provide an optimal learning environment for student discussion on sensitive topics via role-play and simulation in a first-year business ethics unit. The Audience Response System (ARS, online discussion boards and blogs, and wikis are assessed for their suitability in supporting online role-play and simulation. Among these online tools, asynchronous online discussion boards and blogs are the ideal tools for supporting student discussion on sensitive topics in online role-play and simulation.

Differential Topic Models.

Science.gov (United States)

Chen, Changyou; Buntine, Wray; Ding, Nan; Xie, Lexing; Du, Lan

2015-02-01

In applications we may want to compare different document collections: they could have shared content but also different and unique aspects in particular collections. This task has been called comparative text mining or cross-collection modeling. We present a differential topic model for this application that models both topic differences and similarities. For this we use hierarchical Bayesian nonparametric models. Moreover, we found it was important to properly model power-law phenomena in topic-word distributions and thus we used the full Pitman-Yor process rather than just a Dirichlet process. Furthermore, we propose the transformed Pitman-Yor process (TPYP) to incorporate prior knowledge such as vocabulary variations in different collections into the model. To deal with the non-conjugate issue between model prior and likelihood in the TPYP, we thus propose an efficient sampling algorithm using a data augmentation technique based on the multinomial theorem. Experimental results show the model discovers interesting aspects of different collections. We also show the proposed MCMC based algorithm achieves a dramatically reduced test perplexity compared to some existing topic models. Finally, we show our model outperforms the state-of-the-art for document classification/ideology prediction on a number of text collections.

Topic Model for Graph Mining.

Science.gov (United States)

Xuan, Junyu; Lu, Jie; Zhang, Guangquan; Luo, Xiangfeng

2015-12-01

Graph mining has been a popular research area because of its numerous application scenarios. Many unstructured and structured data can be represented as graphs, such as, documents, chemical molecular structures, and images. However, an issue in relation to current research on graphs is that they cannot adequately discover the topics hidden in graph-structured data which can be beneficial for both the unsupervised learning and supervised learning of the graphs. Although topic models have proved to be very successful in discovering latent topics, the standard topic models cannot be directly applied to graph-structured data due to the "bag-of-word" assumption. In this paper, an innovative graph topic model (GTM) is proposed to address this issue, which uses Bernoulli distributions to model the edges between nodes in a graph. It can, therefore, make the edges in a graph contribute to latent topic discovery and further improve the accuracy of the supervised and unsupervised learning of graphs. The experimental results on two different types of graph datasets show that the proposed GTM outperforms the latent Dirichlet allocation on classification by using the unveiled topics of these two models to represent graphs.

Teaching Millennials to Engage THE Environment Instead of Their Environment: A Pedagogical Analysis

Science.gov (United States)

Stevens, J. Richard; Crow, Deserai Anderson

2016-01-01

This article examines the difficulty in teaching contemporary students of journalism (those in the much-discussed Millennial Generation) to report on complex topics like science and the environment. After examining contemporary literature, the authors subjected 120 undergraduate students to a strategy that combined visual representations of…

Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

OpenAIRE

Sung-Chien Lin

2014-01-01

In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results ...

Topics in the Foundations of General Relativity and Newtonian Gravitation Theory

CERN Document Server

Malament, David B

2012-01-01

In Topics in the Foundations of General Relativity and Newtonian Gravitation Theory, David B. Malament presents the basic logical-mathematical structure of general relativity and considers a number of special topics concerning the foundations of general relativity and its relation to Newtonian gravitation theory. These special topics include the geometrized formulation of Newtonian theory (also known as Newton-Cartan theory), the concept of rotation in general relativity, and Gödel spacetime. One of the highlights of the book is a no-go theorem that can be understood to show that there is

Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

Directory of Open Access Journals (Sweden)

Sung-Chien Lin

2014-07-01

Full Text Available In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results of this study show that when the number of topics was set to 10, the topic model has the smallest perplexity. Although data scopes and analysis methodsare different to previous studies, the generating topics of this study are consistent with those results produced by analyses of experts. Empirical case studies and measurements of bibliometric indicators were concerned important in every year during the whole analytic period, and the field was increasing stability. Both the two core journals broadly paid more attention to all of the topics in the field of Informetrics. The Journal of Informetricsput particular emphasis on construction and applications ofbibliometric indicators and Scientometrics focused on the evaluation and the factors of productivity of countries, institutions, domains, and journals.

Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis.

Science.gov (United States)

Shoughy, Samir S; Tabbara, Khalid F

2017-09-01

To evaluate the efficacy of topical tacrloimus eye drops in the treatment of keratitis associated with autoimmune polyglandular syndrome (APS)-1. This is a retrospective review of 10 patients with APS-1. The patients were treated with topical tacrolimus 0.01% solution at The Eye Center, between 1 March 2012 and 30 April 2016. The outcome measures included improvement in visual acuity, photophobia and keratitis following treatment. Clinical assessment was carried out before, during and on the last visit following initiation of therapy. A total of 10 patients were included. There were five male and five female patients. The mean age was 11 years with age range of 3-42 years. The mean duration of treatment with topical tacrolimus was 26 months (range 8-46 months). There was improvement of photophobia in 7 out of 10 patients following therapy with topical tacrolimus. In three patients, the photophobia was persistent. There was no clinically detectable improvement in the severity of keratitis in all patients. The mean best corrected visual acuity was 0.1 before and following therapy. Topical tacrolimus is effective in reducing the photophobia in patients with APS-1-associated keratitis, but showed no effects on the severity of keratitis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

User Participation and Participatory Design: Topics in Computing Education.

Science.gov (United States)

Kautz, Karlheinz

1996-01-01

Discusses user participation and participatory design in the context of formal education for computing professionals. Topics include the current curriculum debate; mathematical- and engineering-based education; traditional system-development training; and an example of a course program that includes computers and society, and prototyping. (53…

The environment, a social question; L'environnement, une question sociale

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-10-01

The French ministry of environment has requested since several years some reflexion studies to independent research centers about some topics falling under its competences. Some of these studies, because of their excellent quality, merited to become publicly available. This book brings together 31 contributions of sociologists, jurists, economists and philosophers. They are grouped according to three topics. The first one concerns the environment representation which appears as a landscape management problem. The second topic deals with the environmental defense actors: associations, non-governmental organizations, pressure groups, ecologists movements etc.. The third topic concerns the major risks: nuclear, prion diseases, greenhouse effect etc.. All these reflexions are organized in two parts, one concerns the sustainable development which combines economy and ecology, and the other concerns the precaution principle and the rights of the future generations. (J.S.)

The Attorney-Client Relationship as a Business Law-Legal Environment Topic

Science.gov (United States)

Levin, Murray S.

2004-01-01

Business school law courses should promote understanding of legal processes affecting business, help students learn to recognize legal issues and manage legal risks, increase ethical sensitivity, and help students to develop critical thinking skills. To this end, business law and legal environment textbooks tend to focus on ethical and legal…

Topical anti-infective sinonasal irrigations: update and literature review.

Science.gov (United States)

Lee, Jivianne T; Chiu, Alexander G

2014-01-01

Sinonasal anti-infective irrigations have emerged as a promising therapeutic modality in the comprehensive management of chronic rhinosinusitis (CRS), particularly in the context of recalcitrant disease. The purpose of this article was to delineate the current spectrum of topical anti-infective therapies available and evaluate their role in the treatment of CRS. A systematic literature review was performed on all studies investigating the use of topical antimicrobial solutions in the medical therapy of CRS. Anti-infective irrigations were stratified into topical antibacterial, antifungal, and additive preparations according to their composition and respective microbicidal properties. The use of topical antibiotic irrigations has been supported by low-level studies in the treatment of refractory CRS, with optimal results achieved in patients who have undergone prior functional endoscopic sinus surgery and received culture-directed therapy. Multiple evidence-based reviews have not established any clinical benefit with the administration of topical antifungals, and their use is not currently recommended in the management of routine CRS. Topical additives including surfactants may be beneficial as adjunctive treatment for recalcitrant CRS, but additional research is needed to investigate their efficacy in comparison with other agents and establish safety profiles. Topical anti-infective solutions are not recommended as first-line therapy for routine CRS but may be considered as a potential option for patients with refractory CRS who have failed traditional medical and surgical intervention. Additional research is necessary to determine which patient populations would derive the most benefit from each respective irrigation regimen and identify potential toxicities associated with prolonged use.

A framework for extracting and representing project knowledge contexts using topic models and dynamic knowledge maps

Science.gov (United States)

Xu, Jin; Li, Zheng; Li, Shuliang; Zhang, Yanyan

2015-07-01

There is still a lack of effective paradigms and tools for analysing and discovering the contents and relationships of project knowledge contexts in the field of project management. In this paper, a new framework for extracting and representing project knowledge contexts using topic models and dynamic knowledge maps under big data environments is proposed and developed. The conceptual paradigm, theoretical underpinning, extended topic model, and illustration examples of the ontology model for project knowledge maps are presented, with further research work envisaged.

Sub-Tenon's anaesthesia versus topical anaesthesia for cataract surgery.

Science.gov (United States)

Guay, Joanne; Sales, Karl

2015-08-27

Local anaesthesia for cataract surgery can be provided by sub-Tenon's or topical anaesthesia. Both techniques offer possible advantages. This review, which originally was published in 2007 and was updated in 2014, was undertaken to compare these two anaesthetic techniques. Our objectives were to compare the effectiveness of topical anaesthesia (with or without intracameral local anaesthetic) versus sub-Tenon's anaesthesia in providing pain relief during cataract surgery. We reviewed pain during administration of anaesthesia, postoperative pain, surgical satisfaction with operating conditions and patient satisfaction with pain relief provided, and we looked at associated complications. We searched the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE (last search in November 2014) and the reference lists of published articles. We looked for conferences abstracts and trials in progress and placed no constraints on language or publication status. We included all randomized studies that compared sub-Tenon's anaesthesia versus topical anaesthesia for cataract surgery. We assessed trial quality and extracted data in the format allowing maximal data inclusion. We included eight studies in this updated review but could retain in the analysis only seven studies on 742 operated eyes of 617 participants. Two cross-over trials included 125 participants, and five parallel trials included 492 participants. These studies were published between 1997 and 2005. The mean age of participants varied from 71.5 years to 83.5 years. The female proportion of participants varied from 54% to 76%. Compared with sub-Tenon's anaesthesia, topical anaesthesia (with or without intracameral injection) for cataract surgery increases intraoperative pain but decreases postoperative pain at 24 hours. The amplitude of the effect (equivalent to 1.1 on a score from 0 to 10 for intraoperative pain, and to 0.2 on the same scale for postoperative pain at 24 hours), although statistically

Preclinical Medical Student Hematology/Oncology Education Environment.

Science.gov (United States)

Zumberg, Marc S; Broudy, Virginia C; Bengtson, Elizabeth M; Gitlin, Scott D

2015-12-01

To better prepare medical students to care for patients in today's changing health-care environment as they transition to continuing their education as residents, many US medical schools have been reviewing and modifying their curricula and are considering integration of newer adult learning techniques, including team-based learning, flipped classrooms, and other active learning approaches (Assoc Am Med Coll. 2014). Directors of hematology/oncology (H/O) courses requested an assessment of today's H/O education environment to help them respond to the ongoing changes in the education content and environment that will be necessary to meet this goal. Several recommendations for the improvement of cancer education resulted from American Association for Cancer Education's (ACCE's) "Cancer Education Survey II" including a call for medical schools to evaluate the effectiveness of current teaching methods in achieving cancer education objectives (Chamberlain et al. J Cancer Educ 7(2):105-114.2014). To understand the current environment and resources used in medical student preclinical H/O courses, an Internet-based, Survey Monkey®-formatted, questionnaire focusing on nine topic areas was distributed to 130 United States Hematology/Oncology Course Directors (HOCDs). HOCDs represent a diverse group of individuals who work in variably supportive environments and who are variably satisfied with their position. Several aspects of these courses remain relatively unchanged from previous assessments, including a predominance of traditional lectures, small group sessions, and examinations that are either written or computer-based. Newer technology, including web-based reproduction of lectures, virtual microscopes, and availability of additional web-based content has been introduced into these courses. A variety of learner evaluation and course assessment approaches are used. The ultimate effectiveness and impact of these changes needs to be determined.

Probabilistic analysis and related topics

CERN Document Server

Bharucha-Reid, A T

1983-01-01

Probabilistic Analysis and Related Topics, Volume 3 focuses on the continuity, integrability, and differentiability of random functions, including operator theory, measure theory, and functional and numerical analysis. The selection first offers information on the qualitative theory of stochastic systems and Langevin equations with multiplicative noise. Discussions focus on phase-space evolution via direct integration, phase-space evolution, linear and nonlinear systems, linearization, and generalizations. The text then ponders on the stability theory of stochastic difference systems and Marko

Topical steroid-damaged skin

Directory of Open Access Journals (Sweden)

Anil Abraham

2014-01-01

Full Text Available Topical steroids, commonly used for a wide range of skin disorders, are associated with side effects both systemic and cutaneous. This article aims at bringing awareness among practitioners, about the cutaneous side effects of easily available, over the counter, topical steroids. This makes it important for us as dermatologists to weigh the usefulness of topical steroids versus their side effects, and to make an informed decision regarding their use in each individual based on other factors such as age, site involved and type of skin disorder.

Mental Mechanisms for Topics Identification

Directory of Open Access Journals (Sweden)

Louis Massey

2014-01-01

Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

Advanced verification topics

CERN Document Server

Bhattacharya, Bishnupriya; Hall, Gary; Heaton, Nick; Kashai, Yaron; Khan Neyaz; Kirshenbaum, Zeev; Shneydor, Efrat

2011-01-01

The Accellera Universal Verification Methodology (UVM) standard is architected to scale, but verification is growing and in more than just the digital design dimension. It is growing in the SoC dimension to include low-power and mixed-signal and the system integration dimension to include multi-language support and acceleration. These items and others all contribute to the quality of the SOC so the Metric-Driven Verification (MDV) methodology is needed to unify it all into a coherent verification plan. This book is for verification engineers and managers familiar with the UVM and the benefits it brings to digital verification but who also need to tackle specialized tasks. It is also written for the SoC project manager that is tasked with building an efficient worldwide team. While the task continues to become more complex, Advanced Verification Topics describes methodologies outside of the Accellera UVM standard, but that build on it, to provide a way for SoC teams to stay productive and profitable.

Investigating Online Destination Images Using a Topic-Based Sentiment Analysis Approach

Directory of Open Access Journals (Sweden)

Gang Ren

2017-09-01

Full Text Available With the development of Web 2.0, many studies have tried to analyze tourist behavior utilizing user-generated contents. The primary purpose of this study is to propose a topic-based sentiment analysis approach, including a polarity classification and an emotion classification. We use the Latent Dirichlet Allocation model to extract topics from online travel review data and analyze the sentiments and emotions for each topic with our proposed approach. The top frequent words are extracted for each topic from online reviews on Ctrip.com. By comparing the relative importance of each topic, we conclude that many tourists prefer to provide “suggestion” reviews. In particular, we propose a new approach to classify the emotions of online reviews at the topic level utilizing an emotion lexicon, focusing on specific emotions to analyze customer complaints. The results reveal that attraction “management” obtains most complaints. These findings may provide useful insights for the development of attractions and the measurement of online destination image. Our proposed method can be used to analyze reviews from many online platforms and domains.

The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

LENUS (Irish Health Repository)

McHugh, S M

2011-04-01

Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

LENUS (Irish Health Repository)

McHugh, S M

2012-02-01

Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

Efficient Time-Domain Ray-Tracing Technique for the Analysis of Ultra-Wideband Indoor Environments including Lossy Materials and Multiple Effects

Directory of Open Access Journals (Sweden)

F. Saez de Adana

2009-01-01

Full Text Available This paper presents an efficient application of the Time-Domain Uniform Theory of Diffraction (TD-UTD for the analysis of Ultra-Wideband (UWB mobile communications for indoor environments. The classical TD-UTD formulation is modified to include the contribution of lossy materials and multiple-ray interactions with the environment. The electromagnetic analysis is combined with a ray-tracing acceleration technique to treat realistic and complex environments. The validity of this method is tested with measurements performed inside the Polytechnic building of the University of Alcala and shows good performance of the model for the analysis of UWB propagation.

Exposure to topical chloramphenicol during pregnancy and the risk of congenital malformations

DEFF Research Database (Denmark)

Thomseth, Vilde; Cejvanovic, Vanja; Jimenez-Solem, Espen

2015-01-01

PURPOSE: To investigate whether exposure to topical chloramphenicol in the first trimester of pregnancy is associated with congenital malformations. METHODS: The authors conducted a nationwide cohort study including all women giving live birth between 1997 and 2011 in Denmark. All women redeeming...... included. A total of 6024 women were exposed to topical chloramphenicol in the first trimester. The rate of congenital malformations was 3.50% among offspring of exposed mothers and 3.49% among unexposed. Exposure to topical chloramphenicol in the first trimester was not associated with major congenital...... of chloramphenicol eye drops or eye ointment in the first trimester of pregnancy and major congenital malformations. This is in accordance with a previous study analysing the risk of systemic chloramphenicol....

Illicit Drugs and the Environment

Science.gov (United States)

Beginning in the 1970s, the range of chemicals recognized as contributing to widespread contamination of the environment began to be extended to pharmaceuticals, with the topic beginning to attract broader scientific attention around the mid-1990s (Daughton 2009a). Occurring gen...

Remifentanil: A help in topical strabismus surgery.

Science.gov (United States)

Sánchez-Guillén, I; López, R; Calle, M A; Diez-Lobo, A B

2017-12-01

To analyze the analgesic effect of remifentanil, side effects and complications in topical strabismus surgery. To study the results of strabismus surgery with this type of anesthesia. Retrospective descriptive study. We included 39 patients undergoing strabismus surgery with topical anesthesia and analgesia-based sedation with remifentanil. The data of the anesthetic and surgical technique, surgical results and stability of the deviation angle were analyzed. Thirty nine patients (54% women) were included, the average age was 37,4years old. The mean follow-up was 24,5months. The preoperative diagnoses were exotropia (21 patients), esotropia (12), paresis strabismus (4) and Duane's Syndrome (2). 15% patients had preoperative diplopia and 13 had received previous treatments. The dose range of remifentanil used was 0.05 to 0.2μg/kg/min. The side effects presented were 2 cases of vomit and one of bad collaboration during the intraoperative adjustment, one of the patient reported pain and one case of thoracic rigidity was reported. 79% of the patients obtained a good surgical result and 82% reported being satisfied with the results. The reintervention rate was 5%. Analgesia-based sedation with remifentanil is an useful complement to topical strabismus surgery because it reduces pain during surgery and allows the patient to collaborate during intraoperative adjustment due to its pharmacokinetic characteristics. Copyright © 2017 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

Constructing topic models of Internet of Things for information processing.

Science.gov (United States)

Xin, Jie; Cui, Zhiming; Zhang, Shukui; He, Tianxu; Li, Chunhua; Huang, Haojing

2014-01-01

Internet of Things (IoT) is regarded as a remarkable development of the modern information technology. There is abundant digital products data on the IoT, linking with multiple types of objects/entities. Those associated entities carry rich information and usually in the form of query records. Therefore, constructing high quality topic hierarchies that can capture the term distribution of each product record enables us to better understand users' search intent and benefits tasks such as taxonomy construction, recommendation systems, and other communications solutions for the future IoT. In this paper, we propose a novel record entity topic model (RETM) for IoT environment that is associated with a set of entities and records and a Gibbs sampling-based algorithm is proposed to learn the model. We conduct extensive experiments on real-world datasets and compare our approach with existing methods to demonstrate the advantage of our approach.

Constructing Topic Models of Internet of Things for Information Processing

Science.gov (United States)

Xin, Jie; Cui, Zhiming; Zhang, Shukui; He, Tianxu; Li, Chunhua; Huang, Haojing

2014-01-01

Internet of Things (IoT) is regarded as a remarkable development of the modern information technology. There is abundant digital products data on the IoT, linking with multiple types of objects/entities. Those associated entities carry rich information and usually in the form of query records. Therefore, constructing high quality topic hierarchies that can capture the term distribution of each product record enables us to better understand users' search intent and benefits tasks such as taxonomy construction, recommendation systems, and other communications solutions for the future IoT. In this paper, we propose a novel record entity topic model (RETM) for IoT environment that is associated with a set of entities and records and a Gibbs sampling-based algorithm is proposed to learn the model. We conduct extensive experiments on real-world datasets and compare our approach with existing methods to demonstrate the advantage of our approach. PMID:25110737

Capture gamma-ray spectroscopy and related topics, 1984. AIP conference proceedings No. 125

International Nuclear Information System (INIS)

Raman, S.

1985-01-01

The main topics discussed at the symposium were nuclear models and theory, photon-induced reactions, neutron-induced reactions, charged-particle-induced reactions, applications, including nucleosynthesis, and related topics. Separate entries were prepared for the data base for the papers presented

Correlated Topic Vector for Scene Classification.

Science.gov (United States)

Wei, Pengxu; Qin, Fei; Wan, Fang; Zhu, Yi; Jiao, Jianbin; Ye, Qixiang

2017-07-01

Scene images usually involve semantic correlations, particularly when considering large-scale image data sets. This paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. Oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., Fisher vector, but do exist in scene images. It is expected that the involvement of correlations can increase the discriminative capability of the learned generative model and consequently improve the recognition accuracy. Incorporated with the Fisher kernel method, correlated topic vector inherits the advantages of Fisher vector. The contributions to the topics of visual words have been further employed by incorporating the Fisher kernel framework to indicate the differences among scenes. Combined with the deep convolutional neural network (CNN) features and Gibbs sampling solution, correlated topic vector shows great potential when processing large-scale and complex scene image data sets. Experiments on two scene image data sets demonstrate that correlated topic vector improves significantly the deep CNN features, and outperforms existing Fisher kernel-based features.

Proceedings of the topical session on stakeholder involvement in decommissioning projects

International Nuclear Information System (INIS)

Santiago, Juan Luis; Chandler, Steve; Metcalfe, Doug; Le Bars, Yves

2006-01-01

Set up by the Radioactive Waste Management Committee (RWMC), the WPDD brings together senior representatives of national organisations who have a broad overview of Decommissioning and Dismantling (D and D) issues through their work as regulators, implementers, R and D experts or policy makers. These include representatives from regulatory authorities, industrial decommissioners from the NEA Co-operative Programme on Exchange of Scientific and Technical Information on Nuclear Installation Decommissioning Projects (CPD), and cross-representation from the other NEA Committees. The EC is a member of the WPDD and the IAEA is participating as an observer. This broad participation provides good possibilities for the co-ordination efforts amongst activities in the international programmes. At its sixth meeting, in Paris, 14-16 November 2005, the WPDD held a topical session on the 'Stakeholder Involvement in Decommissioning Projects'. The topical session was jointly planned and run with members of the NEA Forum on Stakeholder Confidence (FSC). This report documents the topical session. The main text summarises the lessons learnt and includes the rapporteurs reports. Appendix 1 and 2 provide the agenda of the topical session and all contributed papers respectively. The Topical session also provided a stimuli to review all the contributions in the area of stakeholder involvement that the WPDD has received since its inception. A list of references is provided in Appendix 3. The topical session was meant to provide an exchange of information and experience on the following issues: - Views from Stakeholders Regarding Stakeholder Involvement and Their Own Role. - Case Studies on Stakeholders Confidence. At the end of each session time was allotted for a plenary discussion. The Rapporteur reviewed the main points and the lessons learnt at the end of the whole Topical Session. (authors)

Skin penetration and tissue permeation after topical administration of diclofenac.

Science.gov (United States)

Hagen, Martina; Baker, Mark

2017-09-01

Topical delivery of drugs is an alternative to oral administration, often with similar efficacy but potentially a more favorable tolerability profile. However, topical formulations need to be able to penetrate the skin and permeate to the target areas in quantities sufficient to exert a therapeutic effect. Many factors can affect this process, including the physicochemical properties of the drug, the formulation used, and the site and mode of application. It is believed that measurement of drug concentrations at the sites of action may be an indicator of their likely efficacy. This review addresses these issues, with reference to topically administered diclofenac in osteoarthritis. Articles relevant to this review were identified after a systematic search of Medline and Embase, using the key words "diclofenac", "topical administration" and "osteoarthritis" in the search strategy. The sparse data available indicate that topical diclofenac can penetrate and permeate to deeper tissues, with a lower plasma to tissue ratio than oral diclofenac. The tissue diclofenac levels after topical delivery are sustained over time (at least several hours). However, there is not enough data to establish how diclofenac levels in the joint compare with IC 50 levels (50% of the maximum inhibition of prostaglandin synthesis) established following oral administration. After topical application, diclofenac can penetrate the skin and permeate to deeper tissues, where it reaches a concentration that appears to be sufficient to exert a therapeutic effect. More robust methods are required for in vivo characterization to better estimate the clinical efficacy of topically applied drugs.

Topical treatment of psoriasis: questionnaire results on topical therapy accessibility and influence of body surface area on usage.

Science.gov (United States)

Iversen, L; Lange, M M; Bissonette, R; Carvalho, A V E; van de Kerkhof, P C; Kirby, B; Kleyn, C E; Lynde, C W; van der Walt, J M; Wu, J J

2017-07-01

Topical treatment of mild to moderate psoriasis is first-line treatment and exhibits varying degrees of success across patient groups. Key factors influencing treatment success are physician topical treatment choice (high efficacy, low adverse events) and strict patient adherence. Currently, no formalized, international consensus guidelines exist to direct optimal topical treatment, although many countries have national guidelines. To describe and analyse cross-regional variations in the use and access of psoriasis topical therapies. The study was conducted as an observational cross-sectional study. A survey was distributed to dermatologists from the International Psoriasis Council (IPC) to assess topical therapy accessibility in 26 countries and to understand how body surface area (BSA) categories guide clinical decisions on topical use. Variation in the availability of tars, topical retinoids, dithranol and balneotherapy was reported. The vast majority of respondents (100% and 88.4%) used topical therapy as first-line monotherapy in situations with BSA 10%, the number of respondents who prescribe topical therapy decreased considerably. In addition, combination therapy of a topical drug and a systemic drug was frequently reported when BSA measured >10%. This physician survey provides new evidence on topical access and the influence of disease severity on topical usage in an effort to improve treatment strategies on a global level. © 2017 European Academy of Dermatology and Venereology.

Designing Environment for Teaching Internet of Things

Science.gov (United States)

Simic, Konstantin; Vujin, Vladimir; Labus, Aleksandra; Stepanic, Ðorde; Stevanovic, Mladen

2014-01-01

One of the new topics taught at technical universities is Internet of Things. In this paper, a workshop for organizing a lab in academic environment for the subject Internet of Things is described. The architecture of the platform, scenario and a description of components used for creating the environment for learning Internet of things are also…

Advanced topics in the arithmetic of elliptic curves

CERN Document Server

Silverman, Joseph H

1994-01-01

In the introduction to the first volume of The Arithmetic of Elliptic Curves (Springer-Verlag, 1986), I observed that "the theory of elliptic curves is rich, varied, and amazingly vast," and as a consequence, "many important topics had to be omitted." I included a brief introduction to ten additional topics as an appendix to the first volume, with the tacit understanding that eventually there might be a second volume containing the details. You are now holding that second volume. it turned out that even those ten topics would not fit Unfortunately, into a single book, so I was forced to make some choices. The following material is covered in this book: I. Elliptic and modular functions for the full modular group. II. Elliptic curves with complex multiplication. III. Elliptic surfaces and specialization theorems. IV. Neron models, Kodaira-Neron classification of special fibers, Tate's algorithm, and Ogg's conductor-discriminant formula. V. Tate's theory of q-curves over p-adic fields. VI. Neron's theory of can...

Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application

Directory of Open Access Journals (Sweden)

Fabien Havas

2018-01-01

Full Text Available The colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes and in human plasma, internal tissues, and skin. Being naturally present in common foods, their intake at dietary levels is not expected to present a safety concern. However, since the interest in these compounds in the context of many applications is expanding, it is important to conduct studies aimed at assessing their safety. We present here results of in vitro cytotoxicity and genotoxicity studies, revealing no significant cytotoxic or genotoxic potential and of short- and long-term human in vivo skin compatibility studies with phytoene- and phytofluene-rich tomato and Dunaliella salina alga extracts, showing a lack of irritancy or sensitization reactions. These results support the safe use of phytoene- and phytofluene-rich products in human topical applications.

13th International Conference on Man-Machine-Environment System Engineering

CERN Document Server

Dhillon, Balbir

2014-01-01

The integrated and advanced science research topic Man-Machine-Environment System Engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science and technology in China!”   MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, “man” refers to people in the workplace (e.g. operators, decision-makers); “ machine” is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and “environment” describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of Man-Machine-Environment system...

14th International Conference on Man-Machine-Environment System Engineering

CERN Document Server

Dhillon, Balbir

2015-01-01

The integrated and advanced science research topic man-machine-environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science and technology in China!”   MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, “man” refers to people in the workplace (e.g. operators, decision-makers); “ machine” is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and “environment” describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of man-machine-environment system...

Model to predict the radiological consequences of transportation of radioactive material through an urban environment

International Nuclear Information System (INIS)

Taylor, J.M.; Daniel, S.L.; DuCharme, A.R.; Finley, N.N.

1977-01-01

A model has been developed which predicts the radiological consequences of the transportation of radioactive material in and around urban environments. This discussion of the model includes discussion of the following general topics: health effects from radiation exposure, urban area characterization, computation of dose resulting from normal transportation, computation of dose resulting from vehicular accidents or sabotage, and preliminary results and conclusions

Atomic Processes in Plasmas: Tenth Topical Conference. Proceedings

International Nuclear Information System (INIS)

Osterheld, A.L.; Goldstein, W.H.

1997-01-01

These proceedings contain the papers presented at the 10th topical conference on atomic processes in plasmas held in San Francisco, California. This conference series provides a forum for those whose research overlaps atomic and plasma physics. The topics discussed included tokamak plasmas, x-ray sources and x-ray lasers, dense plasmas, laser plasmas, radiative opacity and atomic databases. Among the sponsors of this conference were the Office of Fusion Energy and the Office of Energy Research of the U.S. department of Energy and Lawrence Livermore National Laboratory. There were 30 papers presented and 28 have been abstracted for the Energy Science and Technology database

Topics on Japanese aseismic design for nuclear installations

International Nuclear Information System (INIS)

Nakamura, Masahiko

2002-01-01

Major items of of Japanese anti-seismic design for nuclear installations involve three topics: earthquakes and ground motion; seismic design and safety evaluation. The first topic deal with: improvement of geological survey technology, evaluation of ground motion from active faults, and characterisation of earthquake from individual faults. Seismic design involves: evaluation of design ground motion (spectra), classification of structures, systems and components (SSCs) based on the seismic importance, and seismic design criteria and critical loads. Safety evaluation of seismic PSA is dependent on the consistency of the the two previous items. Seismic hazard evaluation methodology, database and examples of analysis are described. Analysis method using fault model is included

Topical botulinum toxin.

Science.gov (United States)

Collins, Ashley; Nasir, Adnan

2010-03-01

Nanotechnology is a rapidly growing discipline that capitalizes on the unique properties of matter engineered on the nanoscale. Vehicles incorporating nanotechnology have led to great strides in drug delivery, allowing for increased active ingredient stability, bioavailability, and site-specific targeting. Botulinum toxin has historically been used for the correction of neurological and neuromuscular disorders, such as torticollis, blepharospasm, and strabismus. Recent dermatological indications have been for the management of axillary hyperhydrosis and facial rhytides. Traditional methods of botulinum toxin delivery have been needle-based. These have been associated with increased pain and cost. Newer methods of botulinum toxin formulation have yielded topical preparations that are bioactive in small pilot clinical studies. While there are some risks associated with topical delivery, the refinement and standardization of delivery systems and techniques for the topical administration of botulinum toxin using nanotechnology is anticipated in the near future.

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers.

Science.gov (United States)

Yang, Deng-Fu; Lee, Jeng-Woei; Chen, Hsin-Ming; Hsu, Yih-Chih

2014-09-01

Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT on hamster buccal pouch precancerous lesions. Twenty hamster buccal pouch precancerous lesions were treated with either topical ALA-PDT with topical MTX pretreatment (topical MTX-ALA-PDT group, n = 10) or topical ALA-PDT alone (topical ALA-PDT group, n = 10). The intracellular protoporphyrin IX (PpIX) level in another 12 precancerous lesions (n = 6 for either the topical MTX-ALA or topical ALA group) was monitored by fluorescence spectroscopy. The intracellular PpIX reached its peak level in precancerous lesions 6.5 hours and 2.5 hours after topical ALA application for the topical MTX-ALA group (5.63-fold higher in the lesion than in the normal mucosa) and topical ALA group (2.42-fold higher in the lesion than in the normal mucosa), respectively. The complete response rate of precancerous lesions was 80% for the topical MTX-ALA-PDT group and 70% for the topical ALA-PDT group. In addition, the topical MTX-ALA-PDT group required a significantly lower mean treatment number (2.1 ± 0.6) to achieve complete response than the topical ALA-PDT group (4.4 ± 1.3, p topical MTX-ALA-PDT group had a lower recurrence rate (12.5%) than the topical ALA-PDT group (28.6%). We conclude that topical MTX-pretreatment can increase intracellular PpIX production in hamster buccal pouch precancerous lesions and significantly improves the outcomes of the precancerous lesions treated with topical ALA-PDT. Copyright © 2014. Published by Elsevier B.V.

Active Learning Environment with Lenses in Geometric Optics

Science.gov (United States)

Tural, Güner

2015-01-01

Geometric optics is one of the difficult topics for students within physics discipline. Students learn better via student-centered active learning environments than the teacher-centered learning environments. So this study aimed to present a guide for middle school teachers to teach lenses in geometric optics via active learning environment…

The upper atmosphere and solar-terrestrial relations - An introduction to the aerospace environment

International Nuclear Information System (INIS)

Hargreaves, J.K.

1979-01-01

A theoretical and observational overview of earth's aerospace environment is presented in this book. Emphasis is placed on the principles and observed phenomena of the neutral upper atmosphere, particularly in relation to solar activity. Topics include the structure of the ionosphere and magnetosphere, waves in the magnetosphere, solar flares and solar protons, and storms and other disturbance phenomena, while applications to communications, navigation and space technology are also discussed

Energy use and the environment

International Nuclear Information System (INIS)

Winteringham, F.P.W.

1992-01-01

A global review is presented with particular reference to energy use, society, environment, resources and the future. The text has been prepared as a course of lectures in scientifically accurate but nontechnical language for the student in general education. The first chapters cover the nature of energy, energy use in the global context and energy technologies, resources and uses. A chapter is devoted to each of the different energy types including fossil-carbon based energy, biomass fuels, alternative energies such as solar, wind, geothermal and water, and nuclear based power. After covering the technical basics, the author moves on to the socioeconomic and environmental impacts of energy use. Topics discussed include: energy, agriculture, forestry and fisheries; global trends, problems and needs; sustainable agriculture, food, water, and environmental quality; and energy use, attitudes, and conservation. Finally, the author looks to the future in discussions on education and peaceful planetary management

Dressings and topical agents for preventing pressure ulcers.

Science.gov (United States)

Moore, Zena E H; Webster, Joan

2013-08-18

Pressure ulcers, which are localised injury to the skin, or underlying tissue or both, occur when people are unable to reposition themselves to relieve pressure on bony prominences. Pressure ulcers are often difficult to heal, painful and impact negatively on the individual's quality of life. The cost implications of pressure ulcer treatment are considerable, compounding the challenges in providing cost effective, efficient health services. Efforts to prevent the development of pressure ulcers have focused on nutritional support, pressure redistributing devices, turning regimes and the application of various topical agents and dressings designed to maintain healthy skin, relieve pressure and prevent shearing forces. Although products aimed at preventing pressure ulcers are widely used, it remains unclear which, if any, of these approaches are effective in preventing the development of pressure ulcers. To evaluate the effects of dressings and topical agents on the prevention of pressure ulcers, in people of any age without existing pressure ulcers, but considered to be at risk of developing a pressure ulcer, in any healthcare setting. In February 2013 we searched the following electronic databases to identify reports of relevant randomised clinical trials (RCTs): the Cochrane Wounds Group Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Database of Abstracts of Reviews of Effects (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. We included RCTs evaluating the use of dressings, topical agents, or topical agents with dressings, compared with a different dressing, topical agent, or combined topical agent and dressing, or no intervention or standard care, with the aim of preventing the development of a pressure ulcer. We assessed trials for their appropriateness for inclusion and for their risk of bias. This was done by two review

Topical issues in nuclear, radiation and radioactive waste safety. Contributed papers

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-08-01

The IAEA International Conference on Topical Issues in Nuclear, Radiation and Radioactive Waste Safety was held in Vienna, Austria, 30 August - 4 September 1998 with the objective to foster the exchange of information on topical issues in nuclear, radiation and radioactive waste safety, with the aim of consolidating an international consensus on: the present status of these issues; priorities for future work; and needs for strengthening international co-operation, including recommendations for the IAEA`s future activities. The document includes 43 papers presented at the Conference dealing with the following topical issues: Safety Management; Backfitting, Upgrading and Modernization of NPPs; Regulatory Strategies; Occupational Radiation Protection: Trends and Developments; Situations of Chronic Exposure to Residual Radioactive Materials: Decommissioning and Rehabilitation and Reclamation of Land; Radiation Safety in the Far Future: The Issue of Long Term Waste Disposal. A separate abstract and indexing were provided for each paper. Refs, figs, tabs

Topical issues in nuclear, radiation and radioactive waste safety. Contributed papers

International Nuclear Information System (INIS)

1998-08-01

The IAEA International Conference on Topical Issues in Nuclear, Radiation and Radioactive Waste Safety was held in Vienna, Austria, 30 August - 4 September 1998 with the objective to foster the exchange of information on topical issues in nuclear, radiation and radioactive waste safety, with the aim of consolidating an international consensus on: the present status of these issues; priorities for future work; and needs for strengthening international co-operation, including recommendations for the IAEA's future activities. The document includes 43 papers presented at the Conference dealing with the following topical issues: Safety Management; Backfitting, Upgrading and Modernization of NPPs; Regulatory Strategies; Occupational Radiation Protection: Trends and Developments; Situations of Chronic Exposure to Residual Radioactive Materials: Decommissioning and Rehabilitation and Reclamation of Land; Radiation Safety in the Far Future: The Issue of Long Term Waste Disposal. A separate abstract and indexing were provided for each paper

Topical corticosteroids as adjunctive therapy for bacterial keratitis

Science.gov (United States)

Herretes, Samantha; Wang, Xue; Reyes, Johann MG

2014-01-01

Background Bacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma, and previous ocular or eyelid surgery. Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis, whereas the use of topical corticosteroids as an adjunctive therapy to antibiotics remains controversial. Topical corticosteroids are usually used to control inflammation using the smallest amount of the drug. Their use requires optimal timing, concomitant antibiotics, and careful follow-up. Objectives The objective of the review was to assess the effectiveness and safety of corticosteroids as adjunctive therapy for bacterial keratitis. Secondary objectives included evaluation of health economic outcomes and quality of life outcomes. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 6), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to July 2014), EMBASE (January 1980 to July 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to July 2014), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 14 July 2014. We also searched the Science Citation Index to identify additional studies that had cited the only trial included in the original version of this review, reference lists of included trials, earlier reviews, and the American Academy of Ophthalmology guidelines. We also contacted experts to identify any unpublished and

Handbook of the Solar-Terrestrial Environment

CERN Document Server

Kamide, Y

2007-01-01

The Handbook of the Solar-Terrestrial Environment is a unique compendium. Recognized international leaders in their field contribute chapters on basic topics of solar physics, space plasmas and the Earth's magnetosphere, and on applied topics like the aurora, magnetospheric storms, space weather, space climatology and planetary science. This book will be of highest value as a reference for researchers working in the area of planetary and space science. However, it is also written in a style accessible to graduate students majoring in those fields.

On the Presentation of Pre-Calculus and Calculus Topics: An Alternate View

Science.gov (United States)

Davydov, Aleksandr; Sturm-Beiss, Rachel

2008-01-01

The orders of presentation of pre-calculus and calculus topics, and the notation used, deserve careful study as they affect clarity and ultimately students' level of understanding. We introduce an alternate approach to some of the topics included in this sequence. The suggested alternative is based on years of teaching in colleges within and…

The Effect of Testosterone Topical Solution in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel.

Science.gov (United States)

Burns, Patrick R; Kim, Edward D; Ruff, Dustin D; Seftel, Allen D

2018-05-01

This study evaluated the effect of axillary administration of a 2% testosterone solution (Axiron ® ) in hypogonadal (HGN) men who had had a suboptimal response to treatment with a commercially available topical testosterone gel. HGN men averaging 57 years old, with a mean body mass index of 31.9 kg/m 2 and median baseline testosterone level (T-level) of 185.2 ng/dL, who had failed to reach normal T-levels with a topical testosterone gel (Androgel 1.62%, Androgel, Testim, or Fortesta) were treated with a 2% testosterone solution until T-levels reached a normal range (from ≥300 to ≤1,050 ng/dL) or for up to 9 weeks. Outcomes included the cumulative percentage of men with a serum T-level in the normal range during treatment with Axiron and improvement in symptoms of low energy level and low sexual drive. During the study, 95% of HGN men (72/78) attained a T-level in the normal range. The median T-level at endpoint was 495.7 ng/dL, a threefold increase over baseline, p levels within the first 2 weeks of treatment. In a post hoc analysis, all subjects with baseline body mass indexes >35 kg/m 2 ( n = 19) achieved T-levels in the normal range. Prior to treatment, over 61% of subjects (48/78) reported impairment in either energy level or sexual drive. After treatment (or testosterone normalization), energy level improved in 75% of subjects and sexual drive improved in 70%. Topical 2% testosterone solution is a safe and effective treatment for HGN men who have had a suboptimal response to previous treatment with topical testosterone gels.

Chemistry {ampersand} Materials Science progress report summary of selected research and development topics, FY97

Energy Technology Data Exchange (ETDEWEB)

Newkirk, L.

1997-12-01

This report contains summaries of research performed in the Chemistry and Materials Science division. Topics include Metals and Ceramics, High Explosives, Organic Synthesis, Instrument Development, and other topics.

Topics in mathematical biology

CERN Document Server

Hadeler, Karl Peter

2017-01-01

This book analyzes the impact of quiescent phases on biological models. Quiescence arises, for example, when moving individuals stop moving, hunting predators take a rest, infected individuals are isolated, or cells enter the quiescent compartment of the cell cycle. In the first chapter of Topics in Mathematical Biology general principles about coupled and quiescent systems are derived, including results on shrinking periodic orbits and stabilization of oscillations via quiescence. In subsequent chapters classical biological models are presented in detail and challenged by the introduction of quiescence. These models include delay equations, demographic models, age structured models, Lotka-Volterra systems, replicator systems, genetic models, game theory, Nash equilibria, evolutionary stable strategies, ecological models, epidemiological models, random walks and reaction-diffusion models. In each case we find new and interesting results such as stability of fixed points and/or periodic orbits, excitability...

Music for All: Including young people with intellectual disability in a university environment.

Science.gov (United States)

Rickson, Daphne; Warren, Penny

2017-01-01

We investigated a continuing education course in creative music making, initiated to promote the inclusion of young people with intellectual disability in a university setting. Despite organizers' attempts to foster diversity within the student cohort, enrolments were almost exclusively from students who had intellectual disability. Being in the university environment, and in a place of higher learning, seemed to be valued by some. However, students' main focus was on group musicking in a dedicated music room rather than interacting with the wider university community. Those who did not identify as disabled believed it was important to continue to address the barriers to wider inclusion. While acknowledging the risks around mediating the social interactions of young people with intellectual disability, we argue that future courses should include activities specifically designed to bring them to classes with typical students and to the wider activities of the university.

Recent advances in topical anesthesia

Science.gov (United States)

2016-01-01

Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics. Recently, new products with modified ingredients and application methods have been introduced into the market. These products may be used for mild pain during periodontal treatment, such as scaling. Dentists should be aware that topical anesthetics, although rare, might induce allergic reactions or side effects as a result of an overdose. Topical anesthetics are useful aids during dental treatment, as they reduce dental phobia, especially in children, by mitigating discomfort and pain. PMID:28879311

Discriminative Relational Topic Models.

Science.gov (United States)

Chen, Ning; Zhu, Jun; Xia, Fei; Zhang, Bo

2015-05-01

Relational topic models (RTMs) provide a probabilistic generative process to describe both the link structure and document contents for document networks, and they have shown promise on predicting network structures and discovering latent topic representations. However, existing RTMs have limitations in both the restricted model expressiveness and incapability of dealing with imbalanced network data. To expand the scope and improve the inference accuracy of RTMs, this paper presents three extensions: 1) unlike the common link likelihood with a diagonal weight matrix that allows the-same-topic interactions only, we generalize it to use a full weight matrix that captures all pairwise topic interactions and is applicable to asymmetric networks; 2) instead of doing standard Bayesian inference, we perform regularized Bayesian inference (RegBayes) with a regularization parameter to deal with the imbalanced link structure issue in real networks and improve the discriminative ability of learned latent representations; and 3) instead of doing variational approximation with strict mean-field assumptions, we present collapsed Gibbs sampling algorithms for the generalized relational topic models by exploring data augmentation without making restricting assumptions. Under the generic RegBayes framework, we carefully investigate two popular discriminative loss functions, namely, the logistic log-loss and the max-margin hinge loss. Experimental results on several real network datasets demonstrate the significance of these extensions on improving prediction performance.

Topical ganciclovir in the treatment of acute herpetic keratitis

Directory of Open Access Journals (Sweden)

Khalid F Tabbara

2010-08-01

Full Text Available Khalid F Tabbara1,2,3, Noorjehan Al Balushi11The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, 2Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3The Wilmer Ophthalmological Institute of The Johns Hopkins University School of Medicine, Baltimore, Maryland, USAAbstract: Herpetic keratitis is caused by herpes simplex virus (HSV and is a common cause of corneal blindness. Following a primary ocular herpetic infection, latency of the virus occurs, followed by subsequent recurrences of herpetic keratitis. Such recurrences may lead to structural damage of the cornea. Recurrent herpetic keratitis is a common indication for corneal transplantation. Recurrences of herpetic keratitis in the corneal graft may lead to corneal graft rejection. Several antiviral agents for HSV are available, including the thymidine analogs. Prolonged use of thymidine analogs may lead to toxicity of the ocular surface, including epithelial keratitis, corneal ulcers, follicular conjunctivitis, and punctal occlusions. Availability of topical antiviral agents that are safe and effective in the treatment and prophylaxis of herpetic keratitis is highly desirable. Ganciclovir is a potent inhibitor of members of the herpes virus family. The drug has been used systemically for the treatment of cytomegalovirus (CMV retinitis. Its hematologic toxicity secondary to systemic administration led to its limited use in herpetic infections. On the other hand, topical ganciclovir has been shown to be as safe and effective as acyclovir in the treatment of herpetic epithelial keratitis. Furthermore, topical ganciclovir can reach therapeutic levels in the cornea and aqueous humor following topical application. Several clinical trials have shown that topical ganciclovir 0.15% ophthalmic gel is safe and effective in the treatment and prophylaxis of herpetic epithelial disease. Long-term use of ganciclovir ophthalmic

Topical anesthesia

Directory of Open Access Journals (Sweden)

Mritunjay Kumar

2015-01-01

Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

Irradiation environment and materials behavior

International Nuclear Information System (INIS)

Ishino, Shiori

1992-01-01

Irradiation environment is unique for materials used in a nuclear energy system. Material itself as well as irradiation and environmental conditions determine the material behaviour. In this review, general directions of research and development of materials in an irradiation environment together with the role of materials science are discussed first, and then recent materials problems are described for energy systems which are already existing (LWR), under development (FBR) and to be realized in the future (CTR). Topics selected are (1) irradiation embrittlement of pressure vessel steels for LWRs, (2) high fluence performance of cladding and wrapper materials for fuel subassemblies of FBRs and (3) high fluence irradiation effects in the first wall and blanket structural materials of a fusion reactor. Several common topics in those materials issues are selected and discussed. Suggestions are made on some elements of radiation effects which might be purposely utilized in the process of preparing innovative materials. (J.P.N.) 69 refs

Problematic topic transitions in dysarthric conversation.

Science.gov (United States)

Bloch, Steven; Saldert, Charlotta; Ferm, Ulrika

2015-01-01

This study examined the nature of topic transition problems associated with acquired progressive dysarthric speech in the everyday conversation of people with motor neurone disease. Using conversation analytic methods, a video collection of five naturally occurring problematic topic transitions was identified, transcribed and analysed. These were extracted from a main collection of over 200 other-initiated repair sequences and a sub-set of 15 problematic topic transition sequences. The sequences were analysed with reference to how the participants both identified and resolved the problems. Analysis revealed that topic transition by people with dysarthria can prove problematic. Conversation partners may find transitions problematic not only because of speech intelligibility but also because of a sequential disjuncture between the dysarthric speech turn and whatever topic has come prior. In addition the treatment of problematic topic transition as a complaint reveals the potential vulnerability of people with dysarthria to judgements of competence. These findings have implications for how dysarthria is conceptualized and how specific actions in conversation, such as topic transition, might be suitable targets for clinical intervention.

Traditional Persian topical medications for gastrointestinal diseases

Directory of Open Access Journals (Sweden)

Laleh Dehghani Tafti

2017-03-01

Full Text Available Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI ailments in Traditional Persian Medicine (TPM. TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study is to survey the topical GI remedies and plant species used as ingredients for these remedies in TPM. In addition, pharmacological activities of the mentioned plants have been discussed. For this, we searched major TPM textbooks to find plants used to cure GI problems in topical use. Additionally, scientific databases were searched to obtain pharmacological data supporting the use of TPM plants in GI diseases. Rosa × damascena, Pistacia lentiscus, Malus domestica, Olea europaea and Artemisia absinthium are among the most frequently mentioned ingredients of TPM remedies. β-asarone, amygdalin, boswellic acids, guggulsterone, crocin, crocetin, isomasticadienolic acid, and cyclotides are the most important phytochemicals present in TPM plants with GI-protective activities. Pharmacological studies demonstrated GI activities for TPM plants supporting their extensive traditional use. These plants play pivotal role in alleviating GI disorders through exhibiting numerous activities including antispasmodic, anti-ulcer, anti-secretory, anti-colitis, anti-diarrheal, antibacterial and anthelmintic properties. Several mechanisms underlie these activities including the alleviation of oxidative stress, exhibiting cytoprotective activity, down-regulation of the inflammatory cytokines, suppression of the cellular signaling pathways of inflammatory responses, improving re-epithelialization and angiogenesis, down-regulation of anti-angiogenic factors, blocking activity of acetylcholine, etc.

76 FR 81806 - Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution

Science.gov (United States)

2011-12-29

.... FDA-2011-N-0003] Ophthalmic and Topical Dosage Form New Animal Drugs; Ivermectin Topical Solution... solution of ivermectin. DATES: This rule is effective December 29, 2011. FOR FURTHER INFORMATION CONTACT... ANADA 200-318 for [[Page 81807

Main technical topics in 1999

International Nuclear Information System (INIS)

2000-01-01

This Safety Authority annual report strives to present current organizational provisions and future trends in nuclear safety supervision in France and to describe the most outstanding occurrences during the past year. A first part presents nine documents concerning the main topics of 1999: aging of nuclear installations, the Offsite Emergency Plans (PPI), the impact of nuclear activities on man and the environment, the criticality hazards, EDF in 1999, the EPR project, the Andra in 1999, the transport incidents, the nuclear safety in eastern Europe. The second part presents the missions and actions of the Nuclear Installations Safety in the domains of the liabilities, the organization of the nuclear safety control, the regulations of the INB, the public information, the international relations, the crisis management, the radioactive materials transportation, the radioactive wastes. The equipment, the radiation protection and the exploitation of the pressurized water reactors are also treated just as the experimental reactors, the fuel cycle installations and the the nuclear installations dismantling. (A.L.B.)

Optical systems for synchrotron radiation. Lecture 1. Introductory topics. Revision

International Nuclear Information System (INIS)

Howells, M.R.

1986-02-01

Various fundamental topics are considered which underlie the design and use of optical systems for synchrotron radiation. The point of view of linear system theory is chosen which acts as a unifying concept throughout the series. In this context the important optical quantities usually appear as either impulse response functions (Green's functions) or frequency transfer functions (Fourier Transforms of the Green's functions). Topics include the damped harmonic oscillator, free-space optical field propagation, optical properties of materials, dispersion, and the Kramers-Kronig relations

Report of the 2014 Programming Models and Environments Summit

Energy Technology Data Exchange (ETDEWEB)

Heroux, Michael [US Dept. of Energy, Washington, DC (United States); Lethin, Richard [US Dept. of Energy, Washington, DC (United States)

2016-09-19

Programming models and environments play the essential roles in high performance computing of enabling the conception, design, implementation and execution of science and engineering application codes. Programmer productivity is strongly influenced by the effectiveness of our programming models and environments, as is software sustainability since our codes have lifespans measured in decades, so the advent of new computing architectures, increased concurrency, concerns for resilience, and the increasing demands for high-fidelity, multi-physics, multi-scale and data-intensive computations mean that we have new challenges to address as part of our fundamental R&D requirements. Fortunately, we also have new tools and environments that make design, prototyping and delivery of new programming models easier than ever. The combination of new and challenging requirements and new, powerful toolsets enables significant synergies for the next generation of programming models and environments R&D. This report presents the topics discussed and results from the 2014 DOE Office of Science Advanced Scientific Computing Research (ASCR) Programming Models & Environments Summit, and subsequent discussions among the summit participants and contributors to topics in this report.

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

OpenAIRE

Deng-Fu Yang; Jeng-Woei Lee; Hsin-Ming Chen; Yih-Chih Hsu

2014-01-01

Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT on hamster buccal pouch precancerous lesions. Methods: Twenty hamster buccal pouch precancerous lesions were treated with either topical ALA-PDT with topical MTX pretreatment (topical MTX-ALA-PDT group, n = 10) or topical A...

Topical vs. systemic treatments for acute otitis media.

Science.gov (United States)

Thornton, Kathy; Parrish, Francie; Swords, Christine

2011-01-01

Acute otitis media (AOM) is a common condition in children that is often treated with systemic antibiotic therapy; however, research suggests that non-complicated AOM will resolve spontaneously using only eardrops. To determine best practice for the use of systematic antibiotics compared to topical treatment of AOM, a systematic review of evidence was conducted. Cochrane, Medline, CINAHL, and other databases were searched. Inclusion criteria were studies published from 1995-2010 that included children with AOM and were randomized controlled trials (RCTs). Five systematic reviews and five RCTs were included in the review. Current evidence recommends using topical and other alternative approaches for treating non-complicated AOM in children 2 years of age or older; however, many practitioners are not currently following these recommendations for various reasons. Additional research to address these reasons may help determine how to improve practitioner adherence to best practice evidence and guidelines to help reduce the unnecessary use of systemic antibiotics.

Topical immunomodulators in dermatology

Directory of Open Access Journals (Sweden)

Khandpur Sujay

2004-04-01

Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

Sharing health information online in South Korea: motives, topics, and antecedents.

Science.gov (United States)

Kye, S Y; Shim, M; Kim, Y C; Park, K

2017-10-11

This study aimed to examine the motives, topics and antecedents for sharing health information online among Korean Internet users. Eight hundred adults completed a web-based survey exploring the motives; topics; physical, cognitive, affective and environmental factors; and experiences relating to sharing health information online. The motives for not sharing information included information absence and inappropriateness. The most preferred topic was disease. Good subjective health was significantly associated with frequent information sharing while individuals with a history of disease involving themselves or family members were more likely to share health information than were those without such a history. Further, a higher level of depressed mood was related to a higher level of sharing. Internet-related self-efficacy and trust in information delivery channels were positively related to sharing. Future research could extend the factors related to information sharing to include the evaluation of shared information. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Examination of the Topic-Specific Nature of Pedagogical Content Knowledge in Teaching Electrochemical Cells and Nuclear Reactions

Science.gov (United States)

Aydin, Sevgi; Friedrichsen, Patricia M.; Boz, Yezdan; Hanuscin, Deborah L.

2014-01-01

The purpose of this study was to examine experienced chemistry teachers' pedagogical content knowledge (PCK) for two different topics in chemistry to better understand how PCK is specific to topic, including whether all components of PCK are topic-specific and to what degree. To explore the topic-specific nature of PCK, we examined two experienced…

Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas.

Science.gov (United States)

Dalla Costa, Renata; Prindaville, Brea; Wiss, Karen

2018-03-01

Topical timolol maleate has recently gained popularity as a treatment for superficial infantile hemangiomas, but calculating a safe dose of timolol can be time consuming, which may limit the medication's use in fast-paced clinical environments. This report offers a simplified calculation of the maximum daily safe dosage as 1 drop of medication per kilogram of body weight. © 2018 Wiley Periodicals, Inc.

Topics from the theory of numbers

CERN Document Server

Grosswald, Emil

1984-01-01

Many of the important and creative developments in modern mathematics resulted from attempts to solve questions that originate in number theory. The publication of Emil Grosswald’s classic text presents an illuminating introduction to number theory. Combining the historical developments with the analytical approach, Topics from the Theory of Numbers offers the reader a diverse range of subjects to investigate, including: * divisibility * congruences * the Riemann zeta function * Diophantine equations and Fermat’s conjecture * the theory of partitions Comprehensive in nature, Topics from the Theory of Numbers is an ideal text for advanced undergraduates and graduate students alike. "In my opinion it is excellent. It is carefully written and represents clearly a work of a scholar who loves and understands his subject. One can only wish more authors would take such pains and would be as good and honest expositors as Grosswald." — Marc Kac "This book is designed for use in a first course in number theory at...

Machine Learning-Based Classification of 38 Years of Spine-Related Literature Into 100 Research Topics.

Science.gov (United States)

Sing, David C; Metz, Lionel N; Dudli, Stefan

2017-06-01

Retrospective review. To identify the top 100 spine research topics. Recent advances in "machine learning," or computers learning without explicit instructions, have yielded broad technological advances. Topic modeling algorithms can be applied to large volumes of text to discover quantifiable themes and trends. Abstracts were extracted from the National Library of Medicine PubMed database from five prominent peer-reviewed spine journals (European Spine Journal [ESJ], The Spine Journal [SpineJ], Spine, Journal of Spinal Disorders and Techniques [JSDT], Journal of Neurosurgery: Spine [JNS]). Each abstract was entered into a latent Dirichlet allocation model specified to discover 100 topics, resulting in each abstract being assigned a probability of belonging in a topic. Topics were named using the five most frequently appearing terms within that topic. Significance of increasing ("hot") or decreasing ("cold") topic popularity over time was evaluated with simple linear regression. From 1978 to 2015, 25,805 spine-related research articles were extracted and classified into 100 topics. Top two most published topics included "clinical, surgeons, guidelines, information, care" (n = 496 articles) and "pain, back, low, treatment, chronic" (424). Top two hot trends included "disc, cervical, replacement, level, arthroplasty" (+0.05%/yr, P < 0.001), and "minimally, invasive, approach, technique" (+0.05%/yr, P < 0.001). By journal, the most published topics were ESJ-"operative, surgery, postoperative, underwent, preoperative"; SpineJ-"clinical, surgeons, guidelines, information, care"; Spine-"pain, back, low, treatment, chronic"; JNS- "tumor, lesions, rare, present, diagnosis"; JSDT-"cervical, anterior, plate, fusion, ACDF." Topics discovered through latent Dirichlet allocation modeling represent unbiased meaningful themes relevant to spine care. Topic dynamics can provide historical context and direction for future research for aspiring investigators and trainees

Possibilities for a constitutional embodiment of environment protection

International Nuclear Information System (INIS)

Hattenberger, D.

1991-03-01

The main topic is the question of adequacy and desirability of a constitutional rule for the protection of the environment with regard to the specific Austrian situation and the extensive discussion about this topic in German. As variants are discussed a human right of environment, objective categories of constitutional rules (constitutional aims of state's policy) and procedural or organisational rules. It begins with an explanation of the general responsibility of states in the field of environment protection and a determination of the term 'environment '. In respect of a human right first already guaranteed rights are examined for their relevance in the field of conservation with regard to the change in the understanding of human rights. Then arguments pro and against a specific right to environment are mentioned and appraised. With regard to the counter-arguments a subjective right should not be incorporated. A revision of the present concept of human rights would be necessary. Similar arguments are mentioned against the constitution of an objective norm in respect of some judicial decisions of the Austrian Constitutional Court. The problem of the protection of the environment will not be solved with a constitutional rule. It would raise new problems, which would damage the constitution as a fundamental order of human living together. (author)

Perfume dermatitis in children sensitized to balsam of Peru in topical agents.

Science.gov (United States)

Fisher, A A

1990-01-01

Hjorth in his classic monogram "Eczematous Allergy to Balsams" emphasized that sensitization to balsam of Peru is most important since secondary allergens such as "fragrances" are ubiquitous. The application of a topical medication containing balsam of Peru to the skin of an infant, particularly in the occluded diaper area, seems a great way to sensitize the infant not only to balsam of Peru but also to our fragrant environment.

Topics in theoretical and applied statistics

CERN Document Server

Giommi, Andrea

2016-01-01

This book highlights the latest research findings from the 46th International Meeting of the Italian Statistical Society (SIS) in Rome, during which both methodological and applied statistical research was discussed. This selection of fully peer-reviewed papers, originally presented at the meeting, addresses a broad range of topics, including the theory of statistical inference; data mining and multivariate statistical analysis; survey methodologies; analysis of social, demographic and health data; and economic statistics and econometrics.

Topic Modeling of Hierarchical Corpora /

OpenAIRE

Kim, Do-kyum

2014-01-01

The sizes of modern digital libraries have grown beyond our capacity to comprehend manually. Thus we need new tools to help us in organizing and browsing large corpora of text that do not require manually examining each document. To this end, machine learning researchers have developed topic models, statistical learning algorithms for automatic comprehension of large collections of text. Topic models provide both global and local views of a corpus; they discover topics that run through the co...

[Multicenter study comparing the efficacy and tolerance of topical ciprofloxacin (0.3%) versus topical gentamicin (0.3%) in the treatment of simple, non-cholesteatomaous chronic otitis media in the suppurative phase].

Science.gov (United States)

Lorente, J; Sabater, F; Maristany, M; Jiménez, R; Menem, J; Viñas, J; Quesada, P; Traserra, J; Dicenta, M; Abelló, P

1995-01-01

A multicentre double-blind randomized study was carried out to compare topical ciprofloxacin and topical gentamicin in the treatment of simple non-cholesteatomatous purulent chronic otitis media. Three hundred and eight patients were included in the study, 159 treated with ciprofloxacin and 149 treated with gentamicin. The percentage of clinical success (elimination of otorrhoea) was 95% with ciprofloxacin and 94% with gentamicin (ns). Likewise, the percentage of bacteriological erradication was 96% with ciprofloxacin and 93% with gentamicin. Both drugs were well tolerated, without changes in the audiometric values. In these patients, topical ciprofloxacin shows the same efficacy as topical gentamicin without any potential ototoxic effect.

Testosterone Topical

Science.gov (United States)

... not apply any testosterone topical products to your penis or scrotum or to skin that has sores, ... are severe or do not go away: breast enlargement and/or pain decreased sexual desire acne depression ...

Credibility improves topical blog post retrieval

NARCIS (Netherlands)

Weerkamp, W.; de Rijke, M.

2008-01-01

Topical blog post retrieval is the task of ranking blog posts with respect to their relevance for a given topic. To improve topical blog post retrieval we incorporate textual credibility indicators in the retrieval process. We consider two groups of indicators: post level (determined using

Topic prominence in Chinese EFL learners’ interlanguage

Directory of Open Access Journals (Sweden)

Shaopeng Li

2014-01-01

Full Text Available The present study aims to investigate the general characteristics of topicprominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspective. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004. The research target are the topic chain, which is the main topic-prominent structure in Chinese discourse, and zero anaphora, which is the most common topic anaphora in the topic chain. Two important findings emerged from the present study. First, the characteristics of Chinese topic chains are transferrable to the interlanguage of Chinese EFL learners, thus resulting in overgeneralization of the zero anaphora. Second, the interlanguage discourse of Chinese EFL learners reflects a change of the second language acquisition process from topic-prominence to subject-prominence, thus lending support to the discourse transfer hypothesis.

Agenda trending: reciprocity and the predictive capacity of social networking sites in intermedia agenda setting across topics over time

OpenAIRE

Groshek, Jacob; Groshek, Megan Clough

2013-01-01

In the contemporary converged media environment, agenda setting is being transformed by the dramatic growth of audiences that are simultaneously media users and producers. The study reported here addresses related gaps in the literature by first comparing the topical agendas of two leading traditional media outlets (New York Times and CNN) with the most frequently shared stories and trending topics on two widely popular Social Networking Sites (Facebook and Twitter). Time-series analyses of t...

Natural radiation environment III. [Lead Abstract

Energy Technology Data Exchange (ETDEWEB)

Gesell, T.F.; Lowder, W.M. (eds.)

1980-01-01

Separate abstracts were prepared for the 52 research papers presented at this symposium in April 1978. The major topics in this volume deal with penetrating radiation measurements, radiation surveys and population exposure, radioactivity in the indoor environment, and technologically enhanced natural radioactivity. (KRM)

Predictors of Foreign Language Reading Comprehension in a Hypermedia Reading Environment

Science.gov (United States)

Akbulut, Yavuz

2008-01-01

This study investigated factors affecting second/foreign language (L2) reading comprehension in a hypermedia environment within the theoretical framework of dual coding and cognitive load theories, and interactive models of L2 reading. The independent variables were reading ability, topic interest, prior topical knowledge, and the number of times…

Topical corticosteroid-induced rosacea-like dermatitis: A clinical study of 110 cases

Directory of Open Access Journals (Sweden)

Sanjay K Rathi

2011-01-01

Full Text Available Background: Prolonged and continuous use of topical steroids leads to rosacea-like dermatitis with variable clinical presentations. Aims: To study the various clinical presentations of patients with topical corticosteroid-induced rosacea-like dermatitis (TCIRD, who had a history of prolonged and repeated use of topical steroids for reasons other than the known disease entities. Methods: A total of 110 patients were enrolled for the study over a period of 2 years, excluding all those with the known disease entity in which topical steroids were commonly used. Detailed history which also included the source and the type of topical steroid use was taken along with clinical examination. Results: There were 12 males and 98 females with their age ranging from 18 to 54 years. The duration of topical steroid use ranged from 4 months to 20 years. The most common clinical presentation was diffuse erythema of the face. Most of the patients had rebound phenomenon on discontinuation of the steroid. The most common topical steroid used was Betamethasone valerate, which could be due to its easy availability and low cost. Conclusion: Varied clinical presentations are seen with prolonged and continuous use of topical steroids. The treatment of this dermatitis is difficult, requiring complete cessation of the offending steroid, usually done in a tapering fashion.

Topical report review status: Volume 10

International Nuclear Information System (INIS)

1996-03-01

This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review by the NRC. This report is published annually

Chiropractic: MedlinePlus Health Topic

Science.gov (United States)

... for back pain (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Chiropractic updates by ... ENCYCLOPEDIA Chiropractic care for back pain Related Health Topics Back Pain Complementary and Integrative Medicine National Institutes ...

Diets: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Mediterranean diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diets updates by ... foods Diet-busting foods Mediterranean diet Related Health Topics Child Nutrition DASH Eating Plan Diabetic Diet Nutrition ...

Colonoscopy: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Virtual colonoscopy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Colonoscopy updates by ... Colonoscopy Colonoscopy discharge Sigmoidoscopy Virtual colonoscopy Related Health Topics Colonic Diseases Colonic Polyps Colorectal Cancer National Institutes ...

Dialysis: MedlinePlus Health Topic

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... access for hemodialysis (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Dialysis updates by ... for hemodialysis Show More Show Less Related Health Topics Creatinine Kidney Cysts Kidney Failure Peritoneal Disorders National ...

Menopause: MedlinePlus Health Topic

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... Spanish What is Menopause? (National Institute on Aging) Topic Image MedlinePlus Email Updates Get Menopause updates by ... test Menopause Types of hormone therapy Related Health Topics Hormone Replacement Therapy Menstruation Premature Ovarian Failure National ...

Vaginitis: MedlinePlus Health Topic

Science.gov (United States)

... Spanish Vulvovaginitis - overview (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Vaginitis updates by ... Vaginitis test - wet mount Vulvovaginitis - overview Related Health Topics Trichomoniasis Vaginal Diseases Yeast Infections Other Languages Find ...

"Two Cultures" Topics for General Studies Science Courses.

Science.gov (United States)

Larson, James H.

1982-01-01

Theses proposed in C. P. Snow's book "The Two Cultures," including uncommunicative scientific and literary groups, gap between rich and poor, overpopulation, and nuclear war remain viable topics. Discusses the scientific and literary cultural gap and what can be done in general studies science courses to ameliorate the condition.…

Topical amitriptyline and ketamine for the treatment of neuropathic pain.

Science.gov (United States)

Mercadante, Sebastiano

2015-01-01

A neuropathy is a disturbance of function or pathological change in nerves. In some cases, peripheral neuropathic pain may occur due to a lesion or disease of the peripheral somatosensory nervous system. Efficacy of different agents for peripheral neuropathic pain conditions is less than optimal. The administration of topical analgesics might be an option, due to the potential of reduced adverse effects and increased patient compliance. There is major interest in compounding topical analgesics for peripheral neuropathic pain, but several challenges remain for this approach. Topical analgesics have the potential to be a valuable additional approach for the management of peripheral neuropathic pain. Topical amitriptyline-ketamine combination (AK) is a promising agent for peripheral neuropathic pain conditions. Some studies have shown its efficacy in neuropathic pain conditions. However, this data was not uniformely obtained and its role remains still controversial. Efficacy may depend on many factors, including the choice of the vehicle, the concentration, the pain site, and specific diseases. More studies are necessary to support the use of AK in clinical practice.

Topical Acne Treatments and Pregnancy

Science.gov (United States)

Topical Acne Treatments In every pregnancy, a woman starts out with a 3-5% chance of having a baby ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

Symbiosis: Rich, Exciting, Neglected Topic

Science.gov (United States)

Rowland, Jane Thomas

1974-01-01

Argues that the topic of symbiosis has been greatly neglected and underemphasized in general-biology textbooks. Discusses many types and examples of symbiosis, and provides an extensive bibliography of the literature related to this topic. (JR)

Comparison of topical capsaicin and topical turpentine oil for treatment of painful diabetic neuropathy

International Nuclear Information System (INIS)

Musharraf, M.U.; Ahmed, Z.

2017-01-01

Background: Diabetes Mellitus is a pandemic of the modern era owing to our rapidly deteriorating lifestyle. Painful diabetic neuropathy is one of the costliest and disabling complications of diabetes mellitus. No single treatment exists to prevent or reverse neuropathic changes or to provide total pain relief. Topical Capsaicin and Turpentine Oil are found to be effective in treatment of painful diabetic neuropathy. Methods: Patients of either gender with ages between 18 and 70 years having painful diabetic neuropathy already taking one oral drug for painful neuropathy and treatment for diabetes mellitus and an HbA1C less than 8.5% were included while Pregnant or lactating mothers, patients with chronic liver disease and patients with renal insufficiency (creatinine >3.0 mg/dl) and peripheral arterial disease were excluded from study. Patients were randomly divided into two groups (A and B) using computer generated random number table. Group A was given topical application of capsaicin while Group B was given topical application of commercially available turpentine oil over painful site on feet. Results: 300 patients were equally divided in two groups. The patients in group A had a Visual Analog Pain Score of 7.91±5.10 at baseline and 5.10±1.343 after 3 months of treatment (p-value 0.0001). The patients in group B had a Visual Analog Pain Score of 7.83±1.012 at baseline and 5.20±1.187 after 3 months of treatment (p-value 0.0001). Chi Square test was applied to compare efficacy of both groups. It was noted that 71 (53%) had efficacy in group A and 63 (47%) had efficacy in the group B but the difference was not statistically significant. (p-value=0.399). Conclusion: It has been concluded that turpentine oil is effective in managing diabetic neuropathic pain similar to capsaicin cream.

Programming Not Required: Skills and Knowledge for the Digital Library Environment

Science.gov (United States)

Howard, Katherine

2010-01-01

Education for Library and Information professionals in managing the digital environment has been a key topic for discussion within the LIS environment for some time. However, before designing and implementing a program for digital library education, it is prudent to ensure that the skills and knowledge required to work in this environment are…

Prediabetes:MedlinePlus Health Topic

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... in Spanish Prediabetes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Prediabetes updates by ... Glucose tolerance test - non-pregnant Prediabetes Related Health Topics A1C Diabetes Diabetes in Children and Teens Diabetes ...

Diabetes: MedlinePlus Health Topic

Science.gov (United States)

... High blood sugar (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diabetes updates by ... ketones test Show More Show Less Related Health Topics A1C Blood Sugar Diabetes and Pregnancy Diabetes Complications ...

Tracking topic birth and death in LDA.

Energy Technology Data Exchange (ETDEWEB)

Wilson, Andrew T.; Robinson, David Gerald

2011-09-01

Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

Hot topics in Modern Cosmology - SW9 - Slides of the presentations

International Nuclear Information System (INIS)

Berezhiani, Z.; Sigl, G.; Biondi, R.; Volkov, M.; Noller, J.; Starobinsky, A.; Toporensky, A.; Renaux, S.; Pilo, L.; Comelli, D.; Slagter, R.; Novello, M.; Padilla, A.; Antunes, V.; Kamenshchik, A.; Vernieri, D.; Kaloper, N.; Denkiewics, T.; Gohar, H.; Zahariade, G.; Frusciante, N.; Von Strauss, M.

2016-01-01

This 9. Spontaneous Workshop (SW9) brought together specialists on recent insights in Particle Physics, Astrophysics and Cosmology. The aim was to stimulate debate on common topics in views of providing us with innovating ideas. SW9 topics includes: 1) Cosmological parameters - Anomalies in CMB (Cosmic Microwave Background); 2) Dark matter and neutrinos; 3) Gravity - Dark energy; 4) Singular universes; and 5) Cosmological Large Scale Structures - Magnetic Fields; This document is made up of the slides of the presentations

Evaluation of Topical Gel Bases Formulated with Various Essential ...

African Journals Online (AJOL)

Evaluation of Topical Gel Bases Formulated with Various Essential Oils for Antibacterial Activity against Methicillin- Resistant Staphylococcus Aureus. ... Lemon grass and thyme oils were chosen for further studies, including analysis of their composition by gas chromatography–mass spectrometry (GC/MS). Gels were ...

Topics in b-physics

International Nuclear Information System (INIS)

Bjorken, J.D.

1988-09-01

We discuss a few issues in the burgeoning field of physics of hadrons containing the b-quark. These include: A simple parameterization of the Kobayashi-Maskawa matrix featuring a triangle in the complex plane, a review of B/sub s/ and B/sub d/ mixing with special attention given to width-mixing and the CP-violating same-sign dilepton asymmetry, a discussion of the CP-violating decay B/sub d/ → /psi/π + π/sup /minus//, and a discussion of Cp-violating rate asymmetries in the two-body decays Λ/sub b/ → pπ/sup /minus// and Λ/sub b/ → pK/sup /minus//. The concluding discussion concerns generalizations beyond these specific topics. 22 refs., 6 figs

Topics in lightwave transmission systems

CERN Document Server

Li, Tingye

1991-01-01

Topics in Lightwave Transmission Systems is a second volume of a treatise on optical fiber communications that is devoted to the science, engineering, and application of information transmission via optical fibers. The first volume, published in 1985, dealt exclusively with fiber fabrication. The present volume contains topics that pertain to subsystems and systems. The book contains five chapters and begins with discussions of transmitters and receivers, which are basic to systems now operating in the field. Subsequent chapters cover topics relating to coherent systems: frequency and phase m

Non-adherence to topical treatments for actinic keratosis

Directory of Open Access Journals (Sweden)

Shergill B

2013-12-01

Full Text Available Bav Shergill,1 Simon Zokaie,2 Alison J Carr3 1Department of Dermatology, Brighton and Sussex University Hospitals, Elm Grove, Brighton, UK; 2Leo Pharma, Princes Risborough, 3Hamell, London, UK Background: There is limited information on the patterns of use, adherence rates, and factors that impact adherence with topical treatments for actinic keratosis (AK. Objectives: To establish patterns of use and adherence with topical treatments for AK and to identify treatment-related factors that impact on adherence. Methods: A community-based, cross-sectional study was performed using a standardized questionnaire completed online or via telephone interview. Patients were stratified according to the presence of AK lesions on the scalp and/or other extremities; and presence of scarring resulting from treatment. Results: This study included 305 patients with AK who were currently using a patient-applied topical therapy for AK or had used one within the previous 12 months. In total, 88% (n = 268/305 of patients were either non-adherent, non-persistent or both non-adherent and non-persistent to topical therapy. Duration of treatment was associated with increasing rates of non-adherence (adjusted odds ratio [OR]; for treatment durations greater than 4 weeks, 2.2, P < 0.01: 52% of patients were non-adherent with 3–4 week treatment duration; 69% of patients with 4–8 week treatment duration; and 71% of patients with 6–12 week treatment duration. There were similar increases in non-persistence with increasing treatment duration (adjusted OR; for treatment durations greater than 4 weeks, 2.1, P < 0.05. Conclusion: This study found high rates of non-adherence and non-persistence in patients with AK. Duration of treatment was a significant factor contributing to non-adherence and non-persistence to topical treatments. Patient-applied topical therapies that require less frequent application and have shorter treatment duration may be associated with improved

International Conference on Advances of Fractals and Related Topics

CERN Document Server

Lau, Ka-Sing

2014-01-01

This volume collects thirteen expository or survey articles on topics including Fractal Geometry, Analysis of Fractals, Multifractal Analysis, Ergodic Theory and Dynamical Systems, Probability and Stochastic Analysis, written by the leading experts in their respective fields. The articles are based on papers presented at the International Conference on Advances on Fractals and Related Topics, held on December 10-14, 2012 at the Chinese University of Hong Kong. The volume offers insights into a number of exciting, cutting-edge developments in the area of fractals, which has close ties to and applications in other areas such as analysis, geometry, number theory, probability and mathematical physics.   

Environment

International Nuclear Information System (INIS)

McIntyre, A.D.; Turnbull, R.G.H.

1992-01-01

The development of the hydrocarbon resources of the North Sea has resulted in both offshore and onshore environmental repercussions, involving the existing physical attributes of the sea and seabed, the coastline and adjoining land. The social and economic repercussions of the industry were equally widespread. The dramatic and speedy impact of the exploration and exploitation of the northern North Sea resources in the early 1970s, on the physical resources of Scotland was quickly realised together with the concern that any environmental and social damage to the physical and social fabric should be kept to a minimum. To this end, a wide range of research and other activities by central and local government, and other interested agencies was undertaken to extend existing knowledge on the marine and terrestrial environments that might be affected by the oil and gas industry. The outcome of these activities is summarized in this paper. The topics covered include a survey of the marine ecosystems of the North Sea, the fishing industry, the impact of oil pollution on seabirds and fish stocks, the ecology of the Scottish coastline and the impact of the petroleum industry on a selection of particular sites. (author)

Preface. Forest ecohydrological processes in a changing environment.

Science.gov (United States)

Xiaohua Wei; Ge Sun; James Vose; Kyoichi Otsuki; Zhiqiang Zhang; Keith Smetterm

2011-01-01

The papers in this issue are a selection of the presentations made at the second International Conference on Forests and Water in a Changing Environment. This special issue ‘Forest Ecohydrological Processes in a Changing Environment’ covers the topics regarding the effects of forest, land use and climate changes on ecohydrological processes across forest stand,...

International conference on topical issues in nuclear installation safety: Continuous improvement of nuclear safety in a changing world. Book of contributed papers

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

Papers presented at this conference where devoted to the following NPP safety related topical issues: Changing environments - coping with diversity and globalisation; Operating experience - managing changes effectively; Regulatory management systems - adapting to changes in the environment; Long term operations - maintaining safety margins while extending plant lifetime.

Environment, sustainability, and education policy research

DEFF Research Database (Denmark)

McKenzie, Marcia; Rickinson, Mark; Bengtssen, Stefan

Introduction: This session is a two part symposium on the topic of environment and sustainability in relation to educational policy development, enactment, and analysis. This format is modeled on similar formats used in other international conferences, such as the Association of American...... and methodological approaches to policy and policy research. Some key questions to be addressed include:- What kinds of understandings of policy and policy research are informing work in environmental and sustainability education?- Are there interdisiplinary approaches to policy research that can be useful...... for furthering critical education policy analysis?- What are the relationships between policy development and its enactment or implementation? - To what extent has the environmental education field researched policy development and/or enactment?- What might environmental education research have to offer...

16th International Conference on Man-Machine-Environment System Engineering

CERN Document Server

Dhillon, Balbir

2016-01-01

This research topic was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: “You have created a very important modern science subject and technology in China!” MMESE primarily focuses on the relationship between Man, Machine and Environment, studying the optimum combination of man-machine-environment systems. In this system, “Man” refers to working people as the subject in the workplace (e.g. operators, decision-makers); “Machine” is the general name for any object controlled by Man (including tools, machinery, computers, systems and technologies), and “Environment” describes the specific working conditions under which Man and Machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization are to ensure "Safety, High efficiency and Economy" of man-machine-environment systems. These...

Mass Media: The Invisible Environment.

Science.gov (United States)

Glessing, Robert J.; White, William P.

This anthology for students of media consists of essays and articles grouped under four topics: media forms, media content, media environments, and "the last word." Media forms deals with the nature of these kinds of media: electronic, print, film, music, and comics, graffiti, and clothing. Media content contains articles on the news, advertising,…

Update on the Systemic Risks of Superpotent Topical Steroids.

Science.gov (United States)

Nakamura, Mio; Abrouk, Michael; Zhu, Henry; Farahnik, Benjamin; Koo, John; Bhutani, Tina

2017-07-01

INTRODUCTION: The potential for systemic effects due to percutaneous absorption of superpotent topical steroids has been a longstanding concern. The Food and Drug Administration currently recommends limiting the use of superpotent topical steroids to 50g per week for 2 or 4 consecutive weeks depending on the formulation, which is mostly based on the exact duration with which phase 3 clinical trials were allowed to be conducted per the FDA. This article reviews all published clinical incidence of adrenal adverse effects in the medical literature, specifically Cushing's syndrome (CS) and pathologic adrenal suppression (PAAS), to try to ascertain a more realistic limit for the safe use of superpotent topical steroids as it pertains to its potential systemic effects. METHODS: Literature search was conducted using PubMed. Only cases of CS and PAAS secondary to the use of Class I superpotent topical steroids were included. Pediatric cases and full articles unavailable in English were excluded. RESULTS: There were a total of 14 cases of CS and 5 cases of subsequent PAAS found in the current literature. DISCUSSION: From our review of these cases, if the amount used per week is within FDA guidelines, it appears that patients needed to use superpotent topical steroids for far greater than 2 or 4 weeks to develop CS or PAAS. CS did not necessarily predict occurrence of PAAS, but in all cases CS appeared to be a prerequisite for developing PAAS. All cases of CS and all but one case of PAAS were reversible. If excessive amount of greater than 50g per week is avoided, it appears that superpotent topical steroids may be safe to use consecutively for months, perhaps even years, without causing systemic effects. J Drugs Dermatol. 2017;16(7):643-648..

Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

NARCIS (Netherlands)

Koeneman, M. M.; Kruse, Arnold-Jan; Kooreman, L. F. S.; zur Hausen, Axel; Hopman, Anton H N; Sep, S. J. S.; Van Gorp, T.; Slangen, B. F. M.; van Beekhuizen, H. J.; de Sande, Michiel A. J. van; Gerestein, Cornelis G.; Nijman, H. W.; Kruitwagen, R. F. M. P.

2017-01-01

The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia

Topical Nano and Microemulsions for Skin Delivery

Directory of Open Access Journals (Sweden)

Christofori M. R. R. Nastiti

2017-09-01

Full Text Available Nanosystems such as microemulsions (ME and nanoemulsions (NE offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.

Deep Unfolding for Topic Models.

Science.gov (United States)

Chien, Jen-Tzung; Lee, Chao-Hsi

2018-02-01

Deep unfolding provides an approach to integrate the probabilistic generative models and the deterministic neural networks. Such an approach is benefited by deep representation, easy interpretation, flexible learning and stochastic modeling. This study develops the unsupervised and supervised learning of deep unfolded topic models for document representation and classification. Conventionally, the unsupervised and supervised topic models are inferred via the variational inference algorithm where the model parameters are estimated by maximizing the lower bound of logarithm of marginal likelihood using input documents without and with class labels, respectively. The representation capability or classification accuracy is constrained by the variational lower bound and the tied model parameters across inference procedure. This paper aims to relax these constraints by directly maximizing the end performance criterion and continuously untying the parameters in learning process via deep unfolding inference (DUI). The inference procedure is treated as the layer-wise learning in a deep neural network. The end performance is iteratively improved by using the estimated topic parameters according to the exponentiated updates. Deep learning of topic models is therefore implemented through a back-propagation procedure. Experimental results show the merits of DUI with increasing number of layers compared with variational inference in unsupervised as well as supervised topic models.

Topical diclofenac in the treatment of osteoarthritis of the knee

Directory of Open Access Journals (Sweden)

Niklas Schuelert

2011-02-01

Full Text Available Niklas Schuelert, Fiona A Russell, Jason J McDougallDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaAbstract: Osteoarthritis (OA is a common disease that affects millions of people worldwide. As there is no cure for OA, drug treatment to relieve symptoms is the main form of management. Nonsteroidal anti-inflammatory drugs (NSAIDs such as diclofenac are the most commonly used drugs to treat knee OA pain. Unfortunately, these agents are associated with gastrointestinal and cardiovascular risks, which limit their chronic use. Topical NSAIDs are emerging as a viable alternative for managing OA pain. Because a pharmacologically effective dose can be restricted to the site of pain, there is superfluous systemic absorption, and the risk of related adverse effects is minimized. This article reviews the currently available preclinical and clinical information on topical diclofenac for the treatment of OA pain, including data from recently published randomized controlled trials regarding the efficacy and safety of topical diclofenac. Most studies confirm topical diclofenac to be as effective as oral diclofenac with significantly reduced side effects; however, the efficacy of NSAIDs is far from optimal, and more research needs to be done to investigate the underlying mechanisms of OA in order to improve treatment options, especially for patients with NSAID-resistant OA pain.Keywords: osteoarthritis, topical diclofenac, NSAID, joint pain 

Bimatoprost Topical

Science.gov (United States)

... not use a cotton swab or any other brush or applicator to apply topical bimatoprost.To use the solution, follow these steps: Wash your hands and face thoroughly with soap and water. Be sure that all makeup is removed. Do not let the tip of ...

Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib.

Science.gov (United States)

Rothstein, Brooke; Joshipura, Deep; Saraiya, Ami; Abdat, Rana; Ashkar, Huda; Turkowski, Yana; Sheth, Vaneeta; Huang, Victor; Au, Shiu Chung; Kachuk, Courtney; Dumont, Nicole; Gottlieb, Alice B; Rosmarin, David

2017-06-01

Existing therapies for vitiligo are limited in efficacy and can be associated with undesirable side effects. Topical Janus kinase inhibitors may offer a new therapeutic option for vitiligo. We sought to assess the role of topical ruxolitinib 1.5% cream, a Janus kinase inhibitor, in vitiligo treatment. This 20-week, open-label, proof-of-concept trial of twice-daily topical ruxolitinib 1.5% cream was conducted in 12 patients with a minimum of 1% affected body surface area of vitiligo. The primary outcome was percent improvement in Vitiligo Area Scoring Index from baseline to week 20. Of 12 patients screened, 11 were enrolled and 9 completed the study (54.5% men; mean age, 52 years). Four patients with significant facial involvement at baseline had a 76% improvement in facial Vitiligo Area Scoring Index scores at week 20 (95% confidence interval, 53-99%; P = .001). A 23% improvement in overall Vitiligo Area Scoring Index scores was observed in all enrolled patients at week 20 (95% confidence interval, 4-43%; P = .02). Three of 8 patients responded on body surfaces and 1 of 8 patients responded on acral surfaces. Adverse events were minor, including erythema, hyperpigmentation, and transient acne. Limitations of the study include the small sample size and open-label study design. Topical ruxolitinib 1.5% cream provided significant repigmentation in facial vitiligo and may offer a valuable new treatment for vitiligo. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Topics in quantum field theory

NARCIS (Netherlands)

Dams, C.J.F.

2006-01-01

In this PhD-thesis some topics in quantum field theory are considered. The first chapter gives a background to these topics. The second chapter discusses renormalization. In particular it is shown how loop calculations can be performed when using the axial gauge fixing. Fermion creation and

Fifth topical meeting on the technology of fusion energy

International Nuclear Information System (INIS)

1983-04-01

Abstracts are presented of the approximately 250 papers that were presented at the conference. Some of the main topics included the following: (1) next-generation devices, (2) tritium, (3) hybrids, (4) alternate fuels, (5) materials engineering, (6) blanket and first wall engineering, and (7) inertial confinement

The influence of included minerals on the intrinsic reactivity of chars prepared under N{sub 2} and CO{sub 2} environment

Energy Technology Data Exchange (ETDEWEB)

Zhang, Hong; Li, Huan; Chen, Jiabao; Zhao, Bo; Hu, Guangzhou [China Univ. of Mining and Technology, Jiangsu (China). School of Chemical Engineering

2013-07-01

Oxy-fuel technology could be successfully used to retrofit existing coal-fired power plants or alternatively be used to design and build new coal-fired power plants with almost zero emissions. Char reactivity under oxy-fuel conditions will have a significant impact on the coal burnout. In this paper, two fractions, representing organic-rich particles and organic particles with included minerals, were separated from each of three Chinese coals of different rank. They were then devolatilized at 1,450 C in a drop tube furnace (DTF) under N{sub 2} and CO{sub 2} environment, respectively. The chars were subjected to nitrogen adsorption study, thermogravimetric analysis and XRD analysis. It was found that char reactivity of all three pairs of chars were increased under CO{sub 2} environment as compared with that under N{sub 2} environment, but with differing trend. For the organic-rich samples the reactivity difference is increased with decreasing rank. On the contrary, for the samples of organic particles with included minerals, the reactivity difference is decreased with decreasing rank. Mechanism analysis showed that they are resulted not from gasification, but from a combination of changes in surface area and in the orderness of carbon structure in the chars, both of which, in turn, are resulted from the higher heat capacity of CO{sub 2} and the interaction between metastable liquid phase and the included minerals.

Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.

Science.gov (United States)

Mathers, Alicia R; Carey, Cara D; Killeen, Meaghan E; Salvatore, Sonia R; Ferris, Laura K; Freeman, Bruce A; Schopfer, Francisco J; Falo, Louis D

2018-02-01

Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO 2 ), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation. To accomplish this, the effect of topically applied OA-NO 2 on skin inflammation was evaluated using established murine models of contact hypersensitivity (CHS). In contrast to the effects of subcutaneously injected OA-NO 2 , topical OA-NO 2 potentiated hapten-dependent inflammation inducing a sustained neutrophil-dependent inflammatory response characterized by psoriasiform histological features, increased angiogenesis, and an inflammatory infiltrate that included neutrophils, inflammatory monocytes, and γδ T cells. Consistent with these results, HPLC-MS/MS analysis of skin from psoriasis patients displayed a 56% increase in nitro-conjugated linoleic acid (CLA-NO 2 ) levels in lesional skin compared to non-lesional skin. These results suggest that nitro-fatty acids in the skin microenvironment are products of cutaneous inflammatory responses and, in high local concentrations, may exacerbate inflammatory skin diseases. Copyright © 2017 Elsevier Inc. All rights reserved.

Linear algebra and matrices topics for a second course

CERN Document Server

Shapiro, Helene

2015-01-01

Linear algebra and matrix theory are fundamental tools for almost every area of mathematics, both pure and applied. This book combines coverage of core topics with an introduction to some areas in which linear algebra plays a key role, for example, block designs, directed graphs, error correcting codes, and linear dynamical systems. Notable features include a discussion of the Weyr characteristic and Weyr canonical forms, and their relationship to the better-known Jordan canonical form; the use of block cyclic matrices and directed graphs to prove Frobenius's theorem on the structure of the eigenvalues of a nonnegative, irreducible matrix; and the inclusion of such combinatorial topics as BIBDs, Hadamard matrices, and strongly regular graphs. Also included are McCoy's theorem about matrices with property P, the Bruck-Ryser-Chowla theorem on the existence of block designs, and an introduction to Markov chains. This book is intended for those who are familiar with the linear algebra covered in a typical first c...

Learning topic models by belief propagation.

Science.gov (United States)

Zeng, Jia; Cheung, William K; Liu, Jiming

2013-05-01

Latent Dirichlet allocation (LDA) is an important hierarchical Bayesian model for probabilistic topic modeling, which attracts worldwide interest and touches on many important applications in text mining, computer vision and computational biology. This paper represents the collapsed LDA as a factor graph, which enables the classic loopy belief propagation (BP) algorithm for approximate inference and parameter estimation. Although two commonly used approximate inference methods, such as variational Bayes (VB) and collapsed Gibbs sampling (GS), have gained great success in learning LDA, the proposed BP is competitive in both speed and accuracy, as validated by encouraging experimental results on four large-scale document datasets. Furthermore, the BP algorithm has the potential to become a generic scheme for learning variants of LDA-based topic models in the collapsed space. To this end, we show how to learn two typical variants of LDA-based topic models, such as author-topic models (ATM) and relational topic models (RTM), using BP based on the factor graph representations.

The speciation of iodine in the environment

International Nuclear Information System (INIS)

Bulman, R.A.

1986-01-01

The speciation of iodine in the environment is discussed under the following topics: (i) sea surface to atmosphere, (ii) chemistry in bulk seawater, (iii) iodine in rocks, (iv) iodine in soils, (v) iodine in plants and (vi) iodine in solidified wastes. (author)

Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis.

Science.gov (United States)

Hultsch, Thomas; Kapp, Alexander; Spergel, Jonathan

2005-01-01

Atopic dermatitis (AD) is a chronic or chronically relapsing inflammatory skin condition that primarily affects children. Topical corticosteroids have been the mainstay of treatment since the late 1950s. While providing excellent short-term efficacy, topical corticosteroid usage is limited by potential adverse effects, including impairment of the function and viability of Langerhans cells/dendritic cells. The recently introduced topical calcineurin inhibitors pimecrolimus cream 1% (Elidel) and tacrolimus ointment 0.03 and 0.1% (Protopic) exhibit a more selective mechanism of action and do not affect Langerhans cells/dendritic cells. For the immune system of young children 'learning' to mount a balanced Th1/Th2 response, this selective effect has particular benefits. In clinical experience, topical calcineurin inhibitors have been shown to be a safe and effective alternative to topical corticosteroids in almost 7 million patients (>5 million on pimecrolimus; >1.7 million on tacrolimus). Topical pimecrolimus is primarily used in children with mild and moderate AD, whereas tacrolimus is used preferentially in more severe cases. None of the topical calcineurin inhibitors have been associated with systemic immunosuppression-related malignancies known to occur following long-term sustained systemic immunosuppression with oral immunosuppressants (e.g., tacrolimus, cyclosporine A, and corticosteroids) in transplant patients. Preclinical and clinical data suggest a greater skin selectivity and larger safety margin for topical pimecrolimus. (c) 2005 S. Karger AG, Basel

PREFACE: CEWQO Topical Issue CEWQO Topical Issue

Science.gov (United States)

Bozic, Mirjana; Man'ko, Margarita

2009-09-01

demonstrated. Dodonov derives a formula which predicts a photon generation rate in a cavity due to strong variations of the complex dielectric function in a thin layer near an ideally conducting wall (simulation of the dynamic Casimir effect). Skenderovic reports how photons from two femptosecond laser pulses prepare a large molecule in a coherent superposition of vibrational states. The time evolution of this state is interrogated with a third (delayed) pulse which creates a fourth wave, the signal, giving information on the molecular dynamics. Dimitrova et al present lecture demonstrations of interference and quantum erasing with single photons. By considering electromagnetic energy flow lines as photon paths Davidovic et al explain the emergence of an interference pattern in the process of the accumulation of single photon events behind an interference grating. Atoms in a cavity, atom-atom interactions, interactions of atoms with photons and macroscopic bodies is the next important topic in this topical issue. Khanbekyan et al deal with the problem of the spontaneous emission of an excited atom in a high-Q cavity and investigate the regime when the emitted photon belongs to a wave packet simultaneously located inside and outside the cavity. Sambale et al study the resonant Casimir-Polder potential of an excited atom in front of meta-material half-space and show that for long distances it exhibits attenuated oscillations, while close to the surface the potential becomes attractive or repulsive. Buhmann et al study the nonequilibrium Casimir-Polder force on an atom prepared in an incoherent superposition of internal energy-eigenstates, which is placed in a magnetoelectric environment of nonuniform temperature. Lazarou et al discuss how two atoms, interacting with a single cavity, can be coherently evolved into an entangled state when they are controlled by a sequence of Gaussian pulses, named frequency chirps. Bougouffa et al report on field quantization between two parallel

Daily life activity routine discovery in hemiparetic rehabilitation patients using topic models.

Science.gov (United States)

Seiter, J; Derungs, A; Schuster-Amft, C; Amft, O; Tröster, G

2015-01-01

Monitoring natural behavior and activity routines of hemiparetic rehabilitation patients across the day can provide valuable progress information for therapists and patients and contribute to an optimized rehabilitation process. In particular, continuous patient monitoring could add type, frequency and duration of daily life activity routines and hence complement standard clinical scores that are assessed for particular tasks only. Machine learning methods have been applied to infer activity routines from sensor data. However, supervised methods require activity annotations to build recognition models and thus require extensive patient supervision. Discovery methods, including topic models could provide patient routine information and deal with variability in activity and movement performance across patients. Topic models have been used to discover characteristic activity routine patterns of healthy individuals using activity primitives recognized from supervised sensor data. Yet, the applicability of topic models for hemiparetic rehabilitation patients and techniques to derive activity primitives without supervision needs to be addressed. We investigate, 1) whether a topic model-based activity routine discovery framework can infer activity routines of rehabilitation patients from wearable motion sensor data. 2) We compare the performance of our topic model-based activity routine discovery using rule-based and clustering-based activity vocabulary. We analyze the activity routine discovery in a dataset recorded with 11 hemiparetic rehabilitation patients during up to ten full recording days per individual in an ambulatory daycare rehabilitation center using wearable motion sensors attached to both wrists and the non-affected thigh. We introduce and compare rule-based and clustering-based activity vocabulary to process statistical and frequency acceleration features to activity words. Activity words were used for activity routine pattern discovery using topic models

Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.

Science.gov (United States)

Williamson, Deborah A; Carter, Glen P; Howden, Benjamin P

2017-07-01

Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infections can involve application of a topical antimicrobial, which may be an antibiotic (such as mupirocin or fusidic acid) or an antiseptic (such as chlorhexidine or alcohol). However, there is limited evidence to support the widespread prophylactic or therapeutic use of topical agents. Challenges involved in the use of topical antimicrobials include increasing rates of bacterial resistance, local hypersensitivity reactions (particularly to older agents, such as bacitracin), and concerns about the indiscriminate use of antiseptics potentially coselecting for antibiotic resistance. We review the evidence for the major clinical uses of topical antibiotics and antiseptics. In addition, we review the mechanisms of action of common topical agents and define the clinical and molecular epidemiology of antimicrobial resistance in these agents. Moreover, we review the potential use of newer and emerging agents, such as retapamulin and ebselen, and discuss the role of antiseptic agents in preventing bacterial skin infections. A comprehensive understanding of the clinical efficacy and drivers of resistance to topical agents will inform the optimal use of these agents to preserve their activity in the future. Copyright © 2017 American Society for Microbiology.

Evaluation of contact sensitivity to topical drugs in patients with contact dermatitis

Directory of Open Access Journals (Sweden)

Bilge Bülbül Şen

2013-03-01

Full Text Available Background and Design: Topical drugs are an important group of contact allergens. The present study aimed to evaluate contact sensitivity to topical drugs in patients with contact dermatitis. Materials and Methods: Between 2003 and 2008, 129 patients were followed up at the Department of Dermatology at Ankara University School of Medicine with clinically suspected contact sensitivity to topical drugs. In this study, the patch test reactions to the European Standard Battery and topical drugs used by the patients and medicament patch test results were evaluated. Results: Positive patch test reaction to one or more allergens was found in 80 (62.0% of 129 patients included in the study. Sixty-one of the 80 patients (61/129, 47.3% had positive patch test reaction to medicaments. Medicament sensitivity was detected in 37.9% (49/129 of subjects. Nitrofurazone was found to be the most common allergen (18.6%. Discussion: The present study showed that topical drugs are a frequent cause of allergic contact dermatitis. Therefore, the probability of contact sensitivity to topical drugs should also be considered in patients with the clinical diagnosis of allergic contact dermatitis and, suspected cases should be evaluated further with patch testing in order to find the responsible allergens.

Geotechnical support and topical studies for nuclear waste geologic repositories

International Nuclear Information System (INIS)

1989-01-01

The present report lists the technical reviews and comments made during the fiscal year 1988 and summarizes the technical progress of the topical studies. In the area of technical assistance, there were numerous activities detailed in the next section. These included 24 geotechnical support activities, including reviews of 6 Study Plans (SP) and participation in 6 SP Review Workshops, review of one whole document Site Characterization Plan (SCP) and participation in the Assembled Document SCP Review Workshops by 6 LBL reviewers; the hosting of a DOE program review, the rewriting of the project statement of work, 2 trips to technical and planning meetings; preparation of proposed work statements for two new topics for DOE, and 5 instances of technical assistance to DOE. These activities are described in a Table in the following section entitled ''Geoscience Technical Support for Nuclear Waste Geologic Repositories.''

A Topic Space Oriented User Group Discovering Scheme in Social Network: A Trust Chain Based Interest Measuring Perspective

Directory of Open Access Journals (Sweden)

Wang Dong

2016-01-01

Full Text Available Currently, user group has become an effective platform for information sharing and communicating among users in social network sites. In present work, we propose a single topic user group discovering scheme, which includes three phases: topic impact evaluation, interest degree measurement, and trust chain based discovering, to enable selecting influential topic and discovering users into a topic oriented group. Our main works include (1 an overview of proposed scheme and its related definitions; (2 topic space construction method based on topic relatedness clustering and its impact (influence degree and popularity degree evaluation; (3 a trust chain model to take user relation network topological information into account with a strength classification perspective; (4 an interest degree (user explicit and implicit interest degree evaluation method based on trust chain among users; and (5 a topic space oriented user group discovering method to group core users according to their explicit interest degrees and to predict ordinary users under implicit interest and user trust chain. Finally, experimental results are given to explain effectiveness and feasibility of our scheme.

Resources for Topics in Architecture.

Science.gov (United States)

Van Noate, Judith, Comp.

This guide for conducting library research on topics in architecture or on the work of a particular architect presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and series list (PASL). Two topics are researched as examples: the contemporary architect Richard Meier, and…

Web directories as topical context

NARCIS (Netherlands)

Kaptein, R.; Kamps, J.; Aly, R.; Hauff, C.; den Hamer, I.; Hiemstra, D.; Huibers, T.; de Jong, F.

2009-01-01

In this paper we explore whether the Open Directory (or DMOZ) can be used to classify queries into topical categories on different levels and whether we can use this topical context to improve retrieval performance. We have set up a user study to let test persons explicitly classify queries into

Aqueous Humor Antimicrobial Activity: In Vitro Analysis after Topical 0.5% Chloramphenicol Application.

Science.gov (United States)

Cagini, Carlo; Dragoni, Annalisa; Orsolini, Giampaolo; Fiore, Tito; Beccasio, Alfredo; Spadea, Leopoldo; Moretti, Amedeo; Mencacci, Antonella

2017-06-01

To assess aqueous humor antimicrobial activity in vitro after topical 0.5% chloramphenicol application. This investigation included 63 eyes from 65 cataract surgery patients. The study group of 48 eyes received preoperatively four topical applications of 0.5% chloramphenicol. The control group of 15 eyes was given no topical applications. Aqueous humor samples were collected for in vitro antimicrobial analysis using Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Pasteurella multocida organisms by means of disk diffusion test. No inhibition halo was observed around all aqueous humor samples from all chloramphenicol-treated patients, irrespective of the sample quantity added to the paper disks, with no significant difference from aqueous humor from untreated control patients. Aqueous humor displayed no bactericidal effect against any of the microorganisms evaluated after topical 0.5% chloramphenicol application.

World Resources: A guide to the Global Environment, 1992-1993

International Nuclear Information System (INIS)

Anon.

1993-01-01

This book, produced in collaboration with the U.N., is a basic information source on the impact humans have had on the earth's environment, with a theme of sustainable development. Part I is an essay on sustainable development, examined in the contest of industrial, industrializing, and non-industrial countries. Part II is a description of the environmental devastation in central Europe. Part III examines global environmental conditions and trends, and part IV consists of tables, each with an interductory text and citations, including such topics as population, development, land cover, food, forests, wildlife, habitats, energy, water, atmosphere, and climate

Link-topic model for biomedical abbreviation disambiguation.

Science.gov (United States)

Kim, Seonho; Yoon, Juntae

2015-02-01

The ambiguity of biomedical abbreviations is one of the challenges in biomedical text mining systems. In particular, the handling of term variants and abbreviations without nearby definitions is a critical issue. In this study, we adopt the concepts of topic of document and word link to disambiguate biomedical abbreviations. We newly suggest the link topic model inspired by the latent Dirichlet allocation model, in which each document is perceived as a random mixture of topics, where each topic is characterized by a distribution over words. Thus, the most probable expansions with respect to abbreviations of a given abstract are determined by word-topic, document-topic, and word-link distributions estimated from a document collection through the link topic model. The model allows two distinct modes of word generation to incorporate semantic dependencies among words, particularly long form words of abbreviations and their sentential co-occurring words; a word can be generated either dependently on the long form of the abbreviation or independently. The semantic dependency between two words is defined as a link and a new random parameter for the link is assigned to each word as well as a topic parameter. Because the link status indicates whether the word constitutes a link with a given specific long form, it has the effect of determining whether a word forms a unigram or a skipping/consecutive bigram with respect to the long form. Furthermore, we place a constraint on the model so that a word has the same topic as a specific long form if it is generated in reference to the long form. Consequently, documents are generated from the two hidden parameters, i.e. topic and link, and the most probable expansion of a specific abbreviation is estimated from the parameters. Our model relaxes the bag-of-words assumption of the standard topic model in which the word order is neglected, and it captures a richer structure of text than does the standard topic model by considering

Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review.

Science.gov (United States)

Farahnik, Benjamin; Sharma, Divya; Alban, Joseph; Sivamani, Raja K

2017-08-01

Patients with psoriasis often enquire about the use of numerous botanical therapeutics. It is important for dermatologists to be aware of the current evidence regarding these agents. We conducted a systematic literature search using the PubMed, MEDLINE, and EMBASE databases for controlled and uncontrolled clinical trials that assessed the use of topical botanical therapeutics for psoriasis. The search included the following keywords: 'psoriasis' and 'plant' or 'herbal' or 'botanical'. We also reviewed citations within articles to identify additional relevant sources. We then further refined the results by route of administration and the topical botanical agents are reviewed herein. A total of 27 controlled and uncontrolled clinical trials addressing the use of topical botanical agents for psoriasis were assessed in this review. We found that the most highly studied and most efficacious topical botanical therapeutics were Mahonia aquifolium, indigo naturalis, aloe vera, and, to a lesser degree, capsaicin. The most commonly reported adverse effects were local skin irritation, erythema, pruritus, burning, and pain. However, the overall evidence for these therapeutics remains limited in quantity and quality. The literature addresses a large number of studies in regard to botanicals for the treatment of psoriasis. While most agents appear to be safe, further research is necessary before topical botanical agents can be consistently recommended to patients.

Unsupervised topic discovery by anomaly detection

OpenAIRE

Cheng, Leon

2013-01-01

Approved for public release; distribution is unlimited With the vast amount of information and public comment available online, it is of increasing interest to understand what is being said and what topics are trending online. Government agencies, for example, want to know what policies concern the public without having to look through thousands of comments manually. Topic detection provides automatic identification of topics in documents based on the information content and enhances many ...

21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Laryngotracheal topical anesthesia applicator. 868... topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used to apply topical anesthetics to a patient's laryngotracheal area. (b) Classification. Class...

CERN and the environment

CERN Multimedia

Corinne Pralavorio

2016-01-01

New webpages answer common questions about CERN and the environment.   One of the new public webpages dedicated to CERN and the environment. Do your neighbours ever ask you about CERN’s environmental impact? And about radiation in particular? If so, the answers to those questions can now be found online on a new set of public webpages dedicated to CERN and the environment. These pages, put together by the Occupational Health, Safety and Environmental Protection (HSE) unit and the groups responsible for CERN's site maintenance, contain a wealth of information on topics linked to the environment, such as biodiversity at CERN, waste management, ionising radiation, and water and electricity consumption. “CERN forms part of the local landscape, with its numerous sites and scientific activities. It’s understandable that people living nearby have questions about the impact of these activities and it’s important that we respond with complete transp...

Topical therapy of atopic dermatitis: controversies from Hippocrates to topical immunomodulators.

Science.gov (United States)

Tilles, Gérard; Wallach, Daniel; Taïeb, Alain

2007-02-01

Although atopic dermatitis can be treated efficiently, there is still much controversy about the risk/benefit ratio of both topical corticosteroids and topical immunomodulators. Conflicting data may be found about the usefulness of bathing, diet regulation, and other therapeutic interventions. These controversies result in part from the persistence of Hippocratic doctrines in modern medical thinking. Humoralist and diathetic doctrines, as they pertain to eczema, are reviewed. The paradoxical worsening of oozing and the deadly hazards of hospitalization before the era of antibiotics are brought to mind. We hope that this historical review will improve the understanding of current controversies and help dermatologists to manage patients with atopic dermatitis and other chronic skin diseases.

Modelling Virtual Environments for Geovisualization

DEFF Research Database (Denmark)

Bodum, Lars

2005-01-01

The use of virtual environments in geovisualization has become a major topic within the last few years. The main reason for this interest in the growing use of 3D models and visual realizations in a wide range of applications concerned with the geographic element of information. The implementation...... within the geographic domain. A categorization of the virtual environments is offered through which the differences between them are highlighted. It is possible to achieve this categorization in many ways from many perspectives since this is not and will not be research of a purely positive nature...

Energy, ecology, and the environment

CERN Document Server

Wilson, Richard F

1974-01-01

Energy, Ecology, and the Environment discusses how our need for energy and the different means required to obtain it affect the environment and the harnessing of different natural resources. The book also aims to show more efficient ways to use and generate energy. The book, after a brief introduction to the concept of energy, covers topics such as the different energy resources and the demands, costs, and policies regarding energy. The book also discusses the problems brought about by the production of energy such as the hazards to nature and man; environmental problems and pollution; and

KEY TOPICS IN SPORTS MEDICINE

Directory of Open Access Journals (Sweden)

Amir Ali Narvani

2006-12-01

Full Text Available Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1 Sports injuries, rehabilitation and injury prevention, 2 Exercise physiology, fitness testing and training, 3 Drugs in sport, 4 Exercise and health promotion, 5 Sport and exercise for special and clinical populations, 6 The psychology of performance and injury. PURPOSE The Key Topics format provides extensive, concise information in an accessible, easy-to-follow manner. AUDIENCE The book is targeted the students and specialists in sports medicine and rehabilitation, athletic training, physiotherapy and orthopaedic surgery. The editors are authorities in their respective fields and this handbook depends on their extensive experience and knowledge accumulated over the years. FEATURES The book contains the information for clinical guidance, rapid access to concise details and facts. It is composed of 99 topics which present the information in an order that is considered logical and progressive as in most texts. Chapter headings are: 1. Functional Anatomy, 2. Training Principles / Development of Strength and Power, 3. Biomechanical Principles, 4. Biomechanical Analysis, 5. Physiology of Training, 6. Monitoring of Training Progress, 7. Nutrition, 8. Hot and Cold Climates, 9. Altitude, 10. Sport and Travelling, 11. Principles of Sport Injury Diagnosis, 12. Principles of Sport and Soft Tissue Management, 13. Principles of Physical Therapy and Rehabilitation, 14. Principles of Sport Injury Prevention, 15. Sports Psychology, 16. Team Sports, 17. Psychological Aspects of Injury in Sport, 18. Injury Repair Process, 19. Basic Biomechanics of Tissue Injury, 20. Plain Film Radiography in Sport, 21. Nuclear Medicine, 22. Diagnostic Ultrasound, 23. MRI Scan, 24. Other Imaging, 5. Head Injury, 26. Eye

Primate dental ecology: How teeth respond to the environment.

Science.gov (United States)

Cuozzo, Frank P; Ungar, Peter S; Sauther, Michelle L

2012-06-01

Teeth are central for the study of ecology, as teeth are at the direct interface between an organism and its environment. Recent years have witnessed a rapid growth in the use of teeth to understand a broad range of topics in living and fossil primate biology. This in part reflects new techniques for assessing ways in which teeth respond to, and interact with, an organism's environment. Long-term studies of wild primate populations that integrate dental analyses have also provided a new context for understanding primate interactions with their environments. These new techniques and long-term field studies have allowed the development of a new perspective-dental ecology. We define dental ecology as the broad study of how teeth respond to, or interact with, the environment. This includes identifying patterns of dental pathology and tooth use-wear, as they reflect feeding ecology, behavior, and habitat variation, including areas impacted by anthropogenic disturbance, and how dental development can reflect environmental change and/or stress. The dental ecology approach, built on collaboration between dental experts and ecologists, holds the potential to provide an important theoretical and practical framework for inferring ecology and behavior of fossil forms, for assessing environmental change in living populations, and for understanding ways in which habitat impacts primate growth and development. This symposium issue brings together experts on dental morphology, growth and development, tooth wear and health, primate ecology, and paleontology, to explore the broad application of dental ecology to questions of how living and fossil primates interact with their environments. Copyright © 2012 Wiley Periodicals, Inc.

Healing gardens: design processes and realizations of beneficial environments

Directory of Open Access Journals (Sweden)

Clare Cooper Marcus

2015-04-01

Full Text Available Having defined the topic and its related management effects in the healthcare environment, this paper reports considerations of specific design processes, including evidence-based design, Integrated Healthcare Strategies, participatory practices and post occupancy evaluation. Landscape of Italian examples follows before a case study of three Californian healing gardens dedicated to cancer patients, linked to a survey of this category of users’ needs in such spaces. Conclusions report the reflection of practical implications deriving from studying North American examples, underlining the opportunity for audit and certification of therapeutic gardens, as well as the chance to export them outside health infrastructures for social needs.

Topic Time Series Analysis of Microblogs

Science.gov (United States)

2014-10-01

may be distributed more globally. Tweets on a specific topic that cluster spatially, temporally or both might be of interest to analysts, marketers ...of $ and @, with the latter only in the case that it is the only character in the token (the @ symbol is significant in its usage by Instagram in...is generated by Instagram . Topic 80, Distance: 143.2101 Top words: 1. rawr 2. ˆ0ˆ 3. kill 4. jurassic 5. dinosaur Analysis: This topic is quite

Classical mechanics including an introduction to the theory of elasticity

CERN Document Server

Hentschke, Reinhard

2017-01-01

This textbook teaches classical mechanics as one of the foundations of physics. It describes the mechanical stability and motion in physical systems ranging from the molecular to the galactic scale. Aside from the standard topics of mechanics in the physics curriculum, this book includes an introduction to the theory of elasticity and its use in selected modern engineering applications, e.g. dynamic mechanical analysis of viscoelastic materials. The text also covers many aspects of numerical mechanics, ranging from the solution of ordinary differential equations, including molecular dynamics simulation of many particle systems, to the finite element method. Attendant Mathematica programs or parts thereof are provided in conjunction with selected examples. Numerous links allow the reader to connect to related subjects and research topics. Among others this includes statistical mechanics (separate chapter), quantum mechanics, space flight, galactic dynamics, friction, and vibration spectroscopy. An introductory...

Topic modelling in the information warfare domain

CSIR Research Space (South Africa)

De Waal, A

2013-11-01

Full Text Available for interesting and relevant topics. The objectives of this paper is to describe topic modelling, put it in context as a useful IW technique and illustrate its use with two examples. They discuss several applications of topic modelling in the safety and security...

US Support Program Topical Meetings 1999 to 2008

Energy Technology Data Exchange (ETDEWEB)

Pepper,S.

2008-06-10

In 1999, the International Safeguards Project Office began organizing topical workshops to explore technical issues facing the International Atomic Energy Agency's Department of Safeguards. Representatives from IAEA member states including the United States, national laboratories and companies were invited to the workshops to discuss the technical issues. In some cases professional facilitators were hired to lead the discussions and in some cases business gaming techniques were employed. Since 1999, the following topics have been addressed Data Communication Technologies (1999), Information Security (2000), Design and Testing for High Reliability (2001), Standardization and Integration of Unattended and Remote Monitoring Systems (2002), Roadmapping: Surveillance (2003), IAEA Seals Technology Roadmapping Workshop (2004), Turning Information Into Knowledge (2004), Safeguards Tools of the Future (2005), and Advanced Sensors for Safeguards (2007). This paper will review the scope of the workshops and summarize their results.

Topical steroid addiction in atopic dermatitis

Directory of Open Access Journals (Sweden)

Fukaya M

2014-10-01

Full Text Available Mototsugu Fukaya,1 Kenji Sato,2 Mitsuko Sato,3 Hajime Kimata,4 Shigeki Fujisawa,5 Haruhiko Dozono,6 Jun Yoshizawa,7 Satoko Minaguchi8 1Tsurumai Kouen Clinic, Nagoya, 2Department of Dermatology, Hannan Chuo Hospital, Osaka, 3Sato Pediatric Clinic, Osaka, 4Kimata Hajime Clinic, Osaka, 5Fujisawa Dermatology Clinic, Tokyo, 6Dozono Medical House, Kagoshima, 7Yoshizawa Dermatology Clinic, Yokohama, 8Department of Dermatology, Kounosu Kyousei Hospital, Saitama, Japan Abstract: The American Academy of Dermatology published a new guideline regarding topical therapy in atopic dermatitis in May 2014. Although topical steroid addiction or red burning skin syndrome had been mentioned as possible side effects of topical steroids in a 2006 review article in the Journal of the American Academy of Dermatology, no statement was made regarding this illness in the new guidelines. This suggests that there are still controversies regarding this illness. Here, we describe the clinical features of topical steroid addiction or red burning skin syndrome, based on the treatment of many cases of the illness. Because there have been few articles in the medical literature regarding this illness, the description in this article will be of some benefit to better understand the illness and to spur discussion regarding topical steroid addiction or red burning skin syndrome. Keywords: topical steroid addiction, atopic dermatitis, red burning skin syndrome, rebound, corticosteroid, eczema

A mathematics sampler topics for the liberal arts

CERN Document Server

Berlinghoff, William P; Skrien, Dale

2001-01-01

Now in its fifth edition, A Mathematics Sampler presents mathematics as both science and art, focusing on the historical role of mathematics in our culture. It uses selected topics from modern mathematics-including computers, perfect numbers, and four-dimensional geometry-to exemplify the distinctive features of mathematics as an intellectual endeavor, a problem-solving tool, and a way of thinking about the rapidly changing world in which we live. A Mathematics Sampler also includes unique LINK sections throughout the book, each of which connects mathematical concepts with areas of interest th

The Topical Factors of Development of the National Competitive Advantages

Directory of Open Access Journals (Sweden)

Kolomiets Ganna M.

2017-01-01

Full Text Available The article considers the qualitative changes of the national competitive advantages as derivatives of the evolution of technological modes in the global business environment; the role of both the formal and the informal institutions in their development and implementation has been analyzed. With this in mind, topical in the development of competitive advantages will be improving the formal institutions in conjunction with the informal: recognition and use of the positive potential of the national values and attitudes. High adaptatibility towards turbulence of the economic environment, desire and capability to master new knowledge, technologies, fulfill one’s own abilities in the native country, should define the focus and content of transformations of the formal institutions. Results of the analysis show that nowadays a value shift is going on, attitudes are being changed, which suggests that there’s a necessity to understand that disposition of power institutions, mistrust to authorities can significantly slow down transformations in the direction of «competitive advantages – competitiveness»

Simulation-Visualization and Self-Assessment Modules' Capabilities in Structural Analysis Course Including Survey Analysis Results

Science.gov (United States)

Kadiam, Subhash Chandra Bose S. V.; Mohammed, Ahmed Ali; Nguyen, Duc T.

2010-01-01

In this paper, we describe an approach to analyze 2D truss/Frame/Beam structures under Flash-based environment. Stiffness Matrix Method (SMM) module was developed as part of ongoing projects on a broad topic "Students' Learning Improvements in Science, Technology, Engineering and Mathematics (STEM) Related Areas" at Old Dominion…

Eye Wear: MedlinePlus Health Topic

Science.gov (United States)

... When You Exercise (National Institute on Aging) - PDF Topic Image MedlinePlus Email Updates Get Eye Wear updates by email What's this? GO Related Health Topics Refractive Errors National Institutes of Health The primary ...

21 CFR 524.1193 - Ivermectin topical solution.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ivermectin topical solution. 524.1193 Section 524...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS OPHTHALMIC AND TOPICAL DOSAGE FORM NEW ANIMAL DRUGS § 524.1193 Ivermectin topical solution. (a) Specifications. Each milliliter (mL) of solution contains 5 milligrams of...

A study of topics for distance education-A survey of U.S. Fish and Wildlife Service employees

Science.gov (United States)

Ratz, Joan M.; Schuster, Rudy M.; Marcy, Ann H.

2011-01-01

The purpose of this study was to identify training topics and distance education technologies preferred by U.S. Fish and Wildlife Service employees. This study was conducted on behalf of the National Conservation Training Center to support their distance education strategy planning and implementation. When selecting survey recipients, we focused on employees in positions involving conservation and environmental education and outreach programming. We conducted the study in two phases. First, we surveyed 72 employees to identify useful training topics. The response rate was 61 percent; respondents were from all regions and included supervisors and nonsupervisors. Five topics for training were identified: creating and maintaining partnerships (partnerships), technology, program planning and development (program planning), outreach methods to engage the community (outreach methods), and evaluation methods. In the second phase, we surveyed 1,488 employees to assess preferences for training among the five topics identified in the first survey and preferences among six distance education technologies: satellite television, video conferencing, audio conferencing, computer mediated training, written resources, and audio resources. Two types of instructor-led training were included on the survey to compare to the technology options. Respondents were asked what types of information, such as basic facts or problem solving skills, were needed for each of the five topics. The adjusted response rate was 64 percent; respondents were from all regions and included supervisors and nonsupervisors. The results indicated clear preferences among respondents for certain training topics and technologies. All five training topics were valued, but the topics of partnerships and technology were given equal value and were valued more than the other three topics. Respondents indicated a desire for training on the topics of partnerships, technology, program planning, and outreach methods. For

Eosinophilic Esophagitis: MedlinePlus Health Topic

Science.gov (United States)

... Esophagitis (EoE) (American Academy of Allergy, Asthma, and Immunology) Also in Spanish Latest News Eosinophilic Esophagitis May ... Pediatric and Adolescent Patients (American College of Gastroenterology) Topic Image Related Health Topics Eosinophilic Disorders Esophagus Disorders ...

Female Infertility: MedlinePlus Health Topic

Science.gov (United States)

... Prolactin blood test (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Female Infertility updates ... Serum progesterone Show More Show Less Related Health Topics Assisted Reproductive Technology Infertility Male Infertility National Institutes ...

Mobility Aids: MedlinePlus Health Topic

Science.gov (United States)

... Mobility Problems (AGS Foundation for Health in Aging) Topic Image MedlinePlus Email Updates Get Mobility Aids updates ... standing and walking Using a cane Related Health Topics Assistive Devices Other Languages Find health information in ...

Genetic Testing: MedlinePlus Health Topic

Science.gov (United States)

... Your Family's Health (National Institutes of Health) - PDF Topic Image MedlinePlus Email Updates Get Genetic Testing updates ... testing and your cancer risk Karyotyping Related Health Topics Birth Defects Genetic Counseling Genetic Disorders Newborn Screening ...

Folic Acid: MedlinePlus Health Topic

Science.gov (United States)

... acid in diet (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Folic Acid updates ... acid - test Folic acid in diet Related Health Topics Vitamins National Institutes of Health The primary NIH ...

Pneumococcal Infections: MedlinePlus Health Topic

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... Prevention, Immunization Action Coalition) - PDF Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumococcal Infections updates ... ray Meningitis - pneumococcal Sputum gram stain Related Health Topics Meningitis Pneumonia Sepsis Sinusitis Streptococcal Infections National Institutes ...

Wilms' Tumor: MedlinePlus Health Topic

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... Spanish Wilms tumor (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Wilms Tumor updates ... ENCYCLOPEDIA After chemotherapy - discharge Wilms tumor Related Health Topics Kidney Cancer National Institutes of Health The primary ...

Child Safety: MedlinePlus Health Topic

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... injuries in children (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Child Safety updates ... safety Preventing head injuries in children Related Health Topics Infant and Newborn Care Internet Safety Motor Vehicle ...

Pneumocystis Infections: MedlinePlus Health Topic

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... Pneumocystis jiroveci pneumonia (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumocystis Infections updates ... GO MEDICAL ENCYCLOPEDIA Pneumocystis jiroveci pneumonia Related Health Topics HIV/AIDS HIV/AIDS and Infections Pneumonia National ...

Collapsed Lung: MedlinePlus Health Topic

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... Spanish Pneumothorax - infants (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Collapsed Lung updates ... Lung surgery Pneumothorax - slideshow Pneumothorax - infants Related Health Topics Chest Injuries and Disorders Lung Diseases Pleural Disorders ...

Male Infertility: MedlinePlus Health Topic

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... Spanish Testicular biopsy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Male Infertility updates ... analysis Sperm release pathway Testicular biopsy Related Health Topics Assisted Reproductive Technology Female Infertility Infertility National Institutes ...

Healthy Aging: MedlinePlus Health Topic

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... Aging National Institute on Aging Also in Spanish Topic Image MedlinePlus Email Updates Get Healthy Aging updates ... 65 Health screening - women - over 65 Related Health Topics Exercise for Seniors Nutrition for Seniors Seniors' Health ...

Psoriatic Arthritis: MedlinePlus Health Topic

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... Handouts Psoriatic arthritis (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Psoriatic Arthritis updates ... this? GO MEDICAL ENCYCLOPEDIA Psoriatic arthritis Related Health Topics Arthritis Psoriasis National Institutes of Health The primary ...

Hip Replacement: MedlinePlus Health Topic

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... invasive hip replacement (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hip Replacement updates ... replacement - precautions Minimally invasive hip replacement Related Health Topics Hip Injuries and Disorders National Institutes of Health ...

Platelet Disorders: MedlinePlus Health Topic

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... Thromobocytopenia - drug-induced (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Platelet Disorders updates ... Willebrand disease Show More Show Less Related Health Topics Bleeding Disorders Blood Clots Blood Count Tests Blood ...

Cardiac Rehabilitation: MedlinePlus Health Topic

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... in Spanish Electrocardiogram (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cardiac Rehabilitation updates ... How to take your pulse Pulse Related Health Topics Heart Attack Heart Diseases How to Prevent Heart ...

Cardiac Arrest: MedlinePlus Health Topic

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... Handouts Cardiac arrest (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Cardiac Arrest updates ... this? GO MEDICAL ENCYCLOPEDIA Cardiac arrest Related Health Topics Arrhythmia CPR Pacemakers and Implantable Defibrillators National Institutes ...

Kawasaki Disease: MedlinePlus Health Topic

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... Spanish Kawasaki disease (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Kawasaki Disease updates ... GO MEDICAL ENCYCLOPEDIA Electrocardiogram Kawasaki disease Related Health Topics Vasculitis National Institutes of Health The primary NIH ...

Diabetic Diet: MedlinePlus Health Topic

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... Sweeteners - sugar substitutes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Diabetic Diet updates ... you have diabetes Sweeteners - sugar substitutes Related Health Topics Blood Sugar Diabetes Diabetes in Children and Teens ...

Infection Control: MedlinePlus Health Topic

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... Staph infections - hospital (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Infection Control updates ... infections when visiting Staph infections - hospital Related Health Topics Hepatitis HIV/AIDS MRSA National Institutes of Health ...

Hearing Aids: MedlinePlus Health Topic

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... for hearing loss (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hearing Aids updates ... MEDICAL ENCYCLOPEDIA Devices for hearing loss Related Health Topics Cochlear Implants Hearing Disorders and Deafness National Institutes ...

Kidney Tests: MedlinePlus Health Topic

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... Spanish Total protein (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Kidney Tests updates ... hour volume Show More Show Less Related Health Topics Kidney Cancer Kidney Diseases National Institutes of Health ...

Ischemic Stroke: MedlinePlus Health Topic

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... Spanish Thrombolytic therapy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Ischemic Stroke updates ... cardiogenic embolism Stroke - slideshow Thrombolytic therapy Related Health Topics Hemorrhagic Stroke Stroke Stroke Rehabilitation National Institutes of ...

Pulmonary Rehabilitation: MedlinePlus Health Topic

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... Handouts Postural drainage (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pulmonary Rehabilitation updates ... this? GO MEDICAL ENCYCLOPEDIA Postural drainage Related Health Topics Lung Diseases National Institutes of Health The primary ...

Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials.

Science.gov (United States)

Deng, Zhen-Han; Zeng, Chao; Yang, Ye; Li, Yu-Sheng; Wei, Jie; Yang, Tuo; Li, Hui; Lei, Guang-Hua

2016-05-01

The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (OA). A meta-analysis of randomized controlled trials was conducted. A comprehensive literature search, covering the databases of Medline, the Cochrane Central Register of Controlled Trials, and EMBASE, was conducted in September 2014 to identify the randomized controlled trials which adopted the topical diclofenac therapy for OA. A total of nine papers were included in this meta-analysis. Topical diclofenac appears to be effective in both pain relief (standard mean differences (SMD) = 0.40; 95 % confidence interval (CI) 0.19 to 0.62; P = 0.0003) and function improvement (SMD = 0.23; 95 % CI 0.03 to 0.43; P = 0.03) when compared with the control group. The sensitivity analysis and subgroup analysis showed that the result of pain intensity was stable and reliable, while the result of physical function improvement was vague. With respect to safety, topical diclofenac demonstrated a higher incidence of adverse events such as dry skin, rash, dermatitis, neck pain, and withdrawal. Topical diclofenac is effective in pain relief as a treatment of OA. It may also have a potential effect in function improvement, which needs further studies to be explored. Although, some adverse effects were observed in the application of topical diclofenac, none of them was serious.

Topical oxygen therapy results in complete wound healing in diabetic foot ulcers.

Science.gov (United States)

Yu, Janelle; Lu, Suzanne; McLaren, Ann-Marie; Perry, Julie A; Cross, Karen M

2016-11-01

Diabetic foot ulcers (DFUs) are a significant problem in an aging population. Fifteen percent of diabetics develop a DFU over their lifetime, which can lead to potential amputation. The 5-year survival rate after amputation is 31%, which is greater than the lifetime risk of mortality from cancer. Topical oxygen is a promising technique for the adjunctive therapy of chronic wounds including DFUs, but few controlled studies exist to support its clinical adoption. The aim of this study was to compare a portable topical oxygen delivery system in patients with nonhealing DFUs to standard best practice. Twenty patients were randomized into a topical oxygen group (n = 10), and a nonplacebo control group with regular dressings and standard care (n = 10), and attended the diabetic foot clinic once weekly for 8 weeks. Ulcer surface area over time was analyzed using standardized digital imaging software. DFUs were present without healing for a mean duration of 76 weeks prior to the study. They found a significant difference in healing rate between patients receiving topical oxygen and those receiving standard care. Topical oxygen, therefore, represents a potentially exciting new technology to shorten healing time in patients with nonhealing DFUs. More prospective randomized and powered studies are needed to determine the benefits of topical oxygen, but our current results are very promising. © 2016 by the Wound Healing Society.

Topical herbal therapies for treating osteoarthritis.

Science.gov (United States)

Cameron, Melainie; Chrubasik, Sigrun

2013-05-31

Before extraction and synthetic chemistry were invented, musculoskeletal complaints were treated with preparations from medicinal plants. They were either administered orally or topically. In contrast to the oral medicinal plant products, topicals act in part as counterirritants or are toxic when given orally. To update the previous Cochrane review of herbal therapy for osteoarthritis from 2000 by evaluating the evidence on effectiveness for topical medicinal plant products. Databases for mainstream and complementary medicine were searched using terms to include all forms of arthritis combined with medicinal plant products. We searched electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, AMED, CINAHL, ISI Web of Science, World Health Organization Clinical Trials Registry Platform) to February 2013, unrestricted by language. We also searched the reference lists from retrieved trials. Randomised controlled trials of herbal interventions used topically, compared with inert (placebo) or active controls, in people with osteoarthritis were included. Two review authors independently selected trials for inclusion, assessed the risk of bias of included studies and extracted data. Seven studies (six different medicinal plant interventions; 785 participants) were included. Single studies (five studies) and non-comparable studies (two studies) precluded pooling of results.Moderate evidence from a single study of 174 people with hand osteoarthritis indicated that treatment with Arnica extract gel probably results in similar benefits as treatment with ibuprofen (non-steroidal anti-inflammatory drug) with a similar number of adverse events. Mean pain in the ibuprofen group was 44.2 points on a 100 point scale; treatment with Arnica gel reduced the pain by 4 points after three weeks: mean difference (MD) -3.8 points (95% confidence intervals (CI) -10.1 to 2.5), absolute reduction 4% (10% reduction to 3% increase). Hand function was 7

A comparison of evaluation metrics for biomedical journals, articles, and websites in terms of sensitivity to topic.

Science.gov (United States)

Fu, Lawrence D; Aphinyanaphongs, Yindalon; Wang, Lily; Aliferis, Constantin F

2011-08-01

Evaluating the biomedical literature and health-related websites for quality are challenging information retrieval tasks. Current commonly used methods include impact factor for journals, PubMed's clinical query filters and machine learning-based filter models for articles, and PageRank for websites. Previous work has focused on the average performance of these methods without considering the topic, and it is unknown how performance varies for specific topics or focused searches. Clinicians, researchers, and users should be aware when expected performance is not achieved for specific topics. The present work analyzes the behavior of these methods for a variety of topics. Impact factor, clinical query filters, and PageRank vary widely across different topics while a topic-specific impact factor and machine learning-based filter models are more stable. The results demonstrate that a method may perform excellently on average but struggle when used on a number of narrower topics. Topic-adjusted metrics and other topic robust methods have an advantage in such situations. Users of traditional topic-sensitive metrics should be aware of their limitations. Copyright © 2011 Elsevier Inc. All rights reserved.

A Comparison of Evaluation Metrics for Biomedical Journals, Articles, and Websites in Terms of Sensitivity to Topic

Science.gov (United States)

Fu, Lawrence D.; Aphinyanaphongs, Yindalon; Wang, Lily; Aliferis, Constantin F.

2011-01-01

Evaluating the biomedical literature and health-related websites for quality are challenging information retrieval tasks. Current commonly used methods include impact factor for journals, PubMed’s clinical query filters and machine learning-based filter models for articles, and PageRank for websites. Previous work has focused on the average performance of these methods without considering the topic, and it is unknown how performance varies for specific topics or focused searches. Clinicians, researchers, and users should be aware when expected performance is not achieved for specific topics. The present work analyzes the behavior of these methods for a variety of topics. Impact factor, clinical query filters, and PageRank vary widely across different topics while a topic-specific impact factor and machine learning-based filter models are more stable. The results demonstrate that a method may perform excellently on average but struggle when used on a number of narrower topics. Topic adjusted metrics and other topic robust methods have an advantage in such situations. Users of traditional topic-sensitive metrics should be aware of their limitations. PMID:21419864

Topology of real algebraic varieties and related topics

CERN Document Server

Kharlamov, V M; Polotovskiĭ, G M; Viro, Oleg Ya

1996-01-01

This volume is dedicated to the memory of the Russian mathematician D. A. Gudkov. It contains papers written by his friends, students, and collaborators and is devoted mainly to the areas where D. A. Gudkov made important contributions. The main topic is the topology of real algebraic varieties. Several papers include new results on the topology of real plane algebraic curves (the Hilbert 16th problem).

Antibiotic Resistance: MedlinePlus Health Topic

Science.gov (United States)

... GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home → Health Topics → Antibiotic Resistance URL of this page: https://medlineplus.gov/antibioticresistance. ...

A systematic review of the evidence for topical use of ginger.

Science.gov (United States)

Ding, Mingshuang; Leach, Matthew J; Bradley, Helen

2013-01-01

The use of ginger as a topical intervention is widely advocated in the popular media. However, there has been no attempt to date to synthesize the evidence for topically administered ginger. To systematically review and synthesize the best available evidence of effectiveness for topical ginger in any condition. CAM on PubMed, CINAHL, Google Scholar, MEDLINE, National Library of Australia, The Cochrane Library, TRIP, pertinent texts, and bibliographies of relevant papers. Data sources were systematically searched for studies investigating the clinical effectiveness of topical ginger, in any form and for any condition, regardless of study design. Studies were limited to those published between 1980 and 2010, and published in English, Mandarin, Cantonese, or Taiwanese. Data were extracted by two authors, independently, using standardized templates. Four studies met the inclusion criteria, including three randomized controlled trials and one non-randomized controlled trial. All studies differed in terms of study population, outcome measures, comparative interventions, and dose and form of ginger used, and thus, were not amenable to meta-analysis. Findings from all trials favored usage of ginger for most outcomes. However, the small sample sizes and inadequate methodological reporting indicate a high risk of bias and the need for caution when interpreting these results. Few studies have investigated the effectiveness of topically administered ginger for any condition. Until the findings of these studies are corroborated by more robust research, and the safety of ginger is adequately established, clinicians should remain cautious about using topical ginger in clinical practice. © 2013 Elsevier Inc. All rights reserved.

Water Fountains in Environment Transformation Correcting

Science.gov (United States)

Sidorenko, M. Yu; Ponomareva, Zh V.

2017-11-01

The article provides information on the means and principles for adjusting the process of the urban environment transformation. The interest in the topic is caused by the fact that the surrounding artificial environment is turning into a dangerous factor in the mechanism of human visual perception which requires immediate, effective intervention in the adjustment of the existing modern buildings. The paper considers The correction with the help of new dominants, small architectural forms, in particular, water fountains. Fountains are an important part of the measures to create a comfortable, environmentally friendly urban human environment. Their planning and functional links with the system of streets, squares, traffic arteries can create the urban plan basis.

Study on phytoremediation in the uranium contaminated environment

International Nuclear Information System (INIS)

Huang Dejuan; Zhu Yean; Hua Rong; Yu Yue; Luo Mingbiao; Liu Qingcheng; Huang Dechao

2012-01-01

Mechanisms of phytoremediation in the uranium contaminated environment are described, and a worldwide overview of the content and progress of the related research topics is provided. Based on the analysis, it is pointed out that we should strengthen the research of plant-microbial coexistence system as well as the research of the related molecular biology and genetic engineering in order to enhance the phytoremediation's efficiency in the uranium contaminated environment. (authors)

Agenda Trending: Reciprocity and the Predictive Capacity of Social Networking Sites in Intermedia Agenda Setting across Topics over Time

Directory of Open Access Journals (Sweden)

Jacob Groshek

2013-08-01

Full Text Available In the contemporary converged media environment, agenda setting is being transformed by the dramatic growth of audiences that are simultaneously media users and producers. The study reported here addresses related gaps in the literature by first comparing the topical agendas of two leading traditional media outlets (New York Times and CNN with the most frequently shared stories and trending topics on two widely popular Social Networking Sites (Facebook and Twitter. Time-series analyses of the most prominent topics identify the extent to which traditional media sets the agenda for social media as well as reciprocal agenda-setting effects of social media topics entering traditional media agendas. In addition, this study examines social intermedia agenda setting topically and across time within social networking sites, and in so doing, adds a vital understanding of where traditional media, online uses, and social media content intersect around instances of focusing events, particularly elections. Findings identify core differences between certain traditional and social media agendas, but also within social media agendas that extend from uses examined here. Additional results further suggest important topical and event-oriented limitations upon the predictive capacit of social networking sites to shape traditional media agendas over time.

Use of a Latent Topic Model for Characteristic Extraction from Health Checkup Questionnaire Data.

Science.gov (United States)

Hatakeyama, Y; Miyano, I; Kataoka, H; Nakajima, N; Watabe, T; Yasuda, N; Okuhara, Y

2015-01-01

When patients complete questionnaires during health checkups, many of their responses are subjective, making topic extraction difficult. Therefore, the purpose of this study was to develop a model capable of extracting appropriate topics from subjective data in questionnaires conducted during health checkups. We employed a latent topic model to group the lifestyle habits of the study participants and represented their responses to items on health checkup questionnaires as a probability model. For the probability model, we used latent Dirichlet allocation to extract 30 topics from the questionnaires. According to the model parameters, a total of 4381 study participants were then divided into groups based on these topics. Results from laboratory tests, including blood glucose level, triglycerides, and estimated glomerular filtration rate, were compared between each group, and these results were then compared with those obtained by hierarchical clustering. If a significant (p topic model and hierarchical clustering grouping revealed that, in the latent topic model method, a small group of participants who reported having subjective signs of urinary disorder were allocated to a single group. The latent topic model is useful for extracting characteristics from a small number of groups from questionnaires with a large number of items. These results show that, in addition to chief complaints and history of past illness, questionnaire data obtained during medical checkups can serve as useful judgment criteria for assessing the conditions of patients.

Process monitoring with optical fibers and harsh environment sensors

International Nuclear Information System (INIS)

Marcus, M.A.; Wang, A.

1999-01-01

This volume contains 35 papers presented at the symposium. Some of the topics covered are: sensors for the energy industry; sensors for materials evaluation and structural monitoring; sensors for engine industry; and other harsh environments sensors

Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach.

Science.gov (United States)

Darlenski, R; Surber, C; Fluhr, J W

2010-12-01

Skin, being exposed directly to the environment, represents a unique model for demonstrating the synergistic effects of intrinsic and extrinsic factors on the ageing process. Ultraviolet radiation (UVR) is the major factor among exogenous stressors responsible for premature skin ageing. The problem of skin ageing has captured public attention and has an important social impact. Different therapeutic approaches have been developed to treat cutaneous ageing and to diminish or prevent the negative effects of UVR. Topical retinoids represent an important and powerful class of molecules in the dermatologist's hands for the treatment of photodamaged skin. Since their introduction more than 20 years ago, topical retinoids have shown beneficial efficacy and good safety profiles in the management of photodamaged skin, and as therapeutic anti-ageing agents. This review provides a brief retrospective of the development of topical retinoids in the treatment of photodamaged skin, elucidates their mechanism of action, delineates their use and addresses clinical, pharmaceutical and regulatory issues in connection with their intended use. © 2010 The Authors. BJD © 2010 British Association of Dermatologists.

Systemic and Topical Use of Tranexamic Acid in Spinal Surgery: A Systematic Review

Science.gov (United States)

Winter, Sebastian F.; Santaguida, Carlo; Wong, Jean; Fehlings, Michael G.

2015-01-01

Study Design Combination of narrative and systematic literature reviews. Objectives Massive perioperative blood loss in complex spinal surgery often requires blood transfusions and can negatively affect patient outcome. Systemic use of the antifibrinolytic agent tranexamic acid (TXA) has become widely used in the management of surgical bleeding. We review the clinical evidence for the use of intravenous TXA as a hemostatic agent in spinal surgery and discuss the emerging role for its complementary use as a topical agent to reduce perioperative blood loss from the surgical site. Through a systematic review of published and ongoing investigations on topical TXA for spinal surgery, we wish to make spine practitioners aware of this option and to suggest opportunities for further investigation in the field. Methods A narrative review of systemic TXA in spinal surgery and topical TXA in surgery was conducted. Furthermore, a systematic search (using PRISMA guidelines) of PubMed (MEDLINE), EMBASE, and Cochrane CENTRAL databases as well as World Health Organization International Clinical Trials Registry Platform, ClinicalTrials.gov (National Institutes of Health), and International Standard Randomized Controlled Trial Number registries was conducted to identify both published literature and ongoing clinical trials on topical TXA in spinal surgery. Results Of 1,631 preliminary search results, 2 published studies were included in the systematic review. Out of 285 ongoing clinical trials matching the search criteria, a total of 4 relevant studies were included and reviewed. Conclusion Intravenous TXA is established as an efficacious hemostatic agent in spinal surgery. Use of topical TXA in surgery suggests similar hemostatic efficacy and potentially improved safety as compared with intravenous TXA. For spinal surgery, the literature on topical TXA is sparse but promising, warranting further clinical investigation and consideration as a clinical option in cases with

Topical anesthetic versus lidocaine infiltration in arteriovenous fistula cannulation

Directory of Open Access Journals (Sweden)

Anisha George

2014-01-01

Full Text Available Background: End stage renal disease (ESRD patients on maintenance hemodialysis undergo arterio-venous fistula (AVF cannulation prior to each hemodialysis session for blood access. Prior to cannulation lidocaine infiltration is done, which is often perceived as painful. Eutectic mixture of local anesthetic (EMLA has been found to significantly reduce pain associated with radial artery cannulation compared with lidocaine infiltration. Aims: To evaluate the efficacy of EMLA compared to infiltration of lidocaine in hemodialysis patients for AVF cannulation. Materials and Methods: A single-centre, crossover study of patients with an AVF on regular maintenance hemodialysis was performed in the dialysis unit of a tertiary care teaching hospital. The site of AVF, number of attempts for AVF cannulation and cannula insertion time were recorded. The patients were asked about the acceptability of application of the anesthetic, delay between anesthetic and cannulation and to score the pain on cannulation. Results: Fifty patients were included in the study. With the visual analog scale, pain score on infiltration was 4.8. Pain score on cannulation after topical application was 2.9 and after infiltration, 2.0. The number of attempts for cannulation and the cannula insertion time were similar. Anesthesia was more stressful in the injectable group rather than the topical group (P < 0.001. Delay between anesthetic and cannulation was unacceptable in the topical group (P < 0.001. Patient compliance was better during infiltration compared to topical (P < 0.005. Mean pain score during infiltration of anesthetic was significantly higher than cannulation pain after either anesthetic, although pain on cannulation was higher in the topical group (P < 0.001. Conclusions: EMLA offers a suitable alternative to lidocaine infiltration for patients using AVF for blood access.

Atom probe field ion microscopy and related topics: A bibliography 1989

International Nuclear Information System (INIS)

Miller, M.K.; Hawkins, A.R.; Russell, K.F.

1990-12-01

This bibliography includes references related to the following topics: atom probe field ion microscopy (APFIM), field ion spectroscopy (FIM), field emission microscopy (FEM), liquid metal ion sources (LMIS), scanning tunneling microscopy (STM), and theory. Technique-orientated studies and applications are included. This bibliography covers the period 1989. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications

Characterization data on the topical carrier DDC642

Directory of Open Access Journals (Sweden)

Eline Desmet

2016-06-01

Full Text Available This article contains original data, figures and methods used in the characterization of the liposomal carrier ‘DDC642’ for topical applications, described in “An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis” (Desmet et al., 2016 [1]. Several elastic liposomal formulations have been evaluated for their ability to encapsulate and deliver RNA interference (RNAi molecules to cultured primary skin cells. The efficiency and effectiveness of these liposomes were compared to that of our previously characterized liposomes, the ‘SECosomes’ (SEC (Geusens et al., 2010 [2]. After selection of a potential superior carrier, based on encapsulation and transfection efficiency data (Desmet et al., 2016 [1], the selected DDC642 liposomes were characterized more in-depth. Herein, a detailed characterization of the DDC642 liposome and RNAi-loaded lipoplexes is given, including the matching protocols.

Large-Scale Topic Detection and Language Model Adaptation

National Research Council Canada - National Science Library

Seymore, Kristie

1997-01-01

.... We have developed a language model adaptation scheme that takes apiece of text, chooses the most similar topic clusters from a set of over 5000 elemental topics, and uses topic specific language...

Properties of structural materials in liquid metal environment. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Borgstedt, H U [ed.

1991-12-15

The International Working Group on Fast Reactors (IWGFR) Specialists Meeting on Properties of Structural Materials in Liquid Metal Environment was held during June 18 to June 20, 1991, at the Nuclear Research Centre (Kernforschungszentrum) in Karlsruhe, Germany. The Specialists Meeting was divided into five technical sessions which addressed topics as follows: Creep-Rupture Behaviour of Structural Materials in Liquid Metal Environment; Behaviour of Materials in Liquid Metal Environments under Off-Normal Conditions;Fatigue and Creep-Fatigue of Structural Materials in Liquid Metal Environment; Crack Propagation in Liquid Sodium; and Conclusions and recommendations. Individual papers have been cataloged separately.

Topical application of hemostatic paste

Directory of Open Access Journals (Sweden)

Mohammad Mizanur Rahman

2017-02-01

Full Text Available As a measure to control minor surgical bleeding, surgeons usually depend on a number of hemostatic aids. Topical use of bovine thrombin is a widely used procedure to arrest such minor bleeding. A 35 year old male sergeant of Bangladesh Air Force presented with repeated development of hematoma in his left thigh without any history of trauma or previous history of bleeding. Critical analysis of the patient’s history, routine and sophisticated hematological investigations revealed that the patient developed anti-thrombin antibody following the application of hemostatic paste in the tooth socket five years back during minor dental procedure to stop ignorable bleeding episodes. Therefore, topical use of hemostatic glue/paste or bovine thrombin should be avoided to desist minor bleeding as recombinant human thrombin is now available for topical use.

Developing topic-specific search filters for PubMed with click-through data.

Science.gov (United States)

Li, J; Lu, Z

2013-01-01

Search filters have been developed and demonstrated for better information access to the immense and ever-growing body of publications in the biomedical domain. However, to date the number of filters remains quite limited because the current filter development methods require significant human efforts in manual document review and filter term selection. In this regard, we aim to investigate automatic methods for generating search filters. We present an automated method to develop topic-specific filters on the basis of users' search logs in PubMed. Specifically, for a given topic, we first detect its relevant user queries and then include their corresponding clicked articles to serve as the topic-relevant document set accordingly. Next, we statistically identify informative terms that best represent the topic-relevant document set using a background set composed of topic irrelevant articles. Lastly, the selected representative terms are combined with Boolean operators and evaluated on benchmark datasets to derive the final filter with the best performance. We applied our method to develop filters for four clinical topics: nephrology, diabetes, pregnancy, and depression. For the nephrology filter, our method obtained performance comparable to the state of the art (sensitivity of 91.3%, specificity of 98.7%, precision of 94.6%, and accuracy of 97.2%). Similarly, high-performing results (over 90% in all measures) were obtained for the other three search filters. Based on PubMed click-through data, we successfully developed a high-performance method for generating topic-specific search filters that is significantly more efficient than existing manual methods. All data sets (topic-relevant and irrelevant document sets) used in this study and a demonstration system are publicly available at http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/CQ_filter/

Quantum mechanics new approaches to selected topics

CERN Document Server

Lipkin, Harry Jeannot

1973-01-01

Acclaimed as ""excellent"" (Nature) and ""very original and refreshing"" (Physics Today), this collection of self-contained studies is geared toward advanced undergraduates and graduate students. Its broad selection of topics includes the Mössbauer effect, many-body quantum mechanics, scattering theory, Feynman diagrams, and relativistic quantum mechanics.Author Harry J. Lipkin, a well-known teacher at Israel's Weizmann Institute, takes an unusual approach by introducing many interesting physical problems and mathematical techniques at a much earlier point than in conventional texts. This meth

Transport phenomena an introduction to advanced topics

CERN Document Server

Glasgow, Larry A

2010-01-01

Enables readers to apply transport phenomena principles to solve advanced problems in all areas of engineering and science This book helps readers elevate their understanding of, and their ability to apply, transport phenomena by introducing a broad range of advanced topics as well as analytical and numerical solution techniques. Readers gain the ability to solve complex problems generally not addressed in undergraduate-level courses, including nonlinear, multidimensional transport, and transient molecular and convective transport scenarios. Avoiding rote memorization, the author em

Expanding Health Technology Assessments to Include Effects on the Environment

DEFF Research Database (Denmark)

Marsh, Kevin; Ganz, Michael Lee; Hsu, John

2016-01-01

decision makers. Health care is an important and sizable sector of the economy that could warrant closer policy attention to its impact on the environment. Considerable work is needed to track decision makers' demands, augment the environmental evidence base, and develop robust methods for capturing......There is growing awareness of the impact of human activity on the climate and the need to stem this impact. Public health care decision makers from Sweden and the United Kingdom have started examining environmental impacts when assessing new technologies. This article considers the case...... and objectives extending beyond health care. Two types of challenges hinder this process. First, the nascent evidence base is insufficient to support the accurate comparison of technologies' environmental impacts. Second, cost-utility analysis, which is favored by many HTA agencies, could capture some...

Affinity between information retrieval system and search topic

International Nuclear Information System (INIS)

Ebinuma, Yukio

1979-01-01

Ten search profiles are tested on the INIS system at the Japan Atomic Energy Research Institute. The results are plotted on recall-precision chart ranging from 100% recall to 100% precision. The curves are not purely systems-dependent nor search-dependent, and are determined substantially by the ''affinity'' between the system and the search topic. The curves are named ''Affinity curves of search topics with information retrieval systems'', and hence retrieval affinity factors are derived. They are obtained not only for individual search topics but also for averages in the system. By such a quantitative examination, the difference of affinity among search topics in a given system, that of the same search topic among various systems, and that of systems to the same group of search topics can be compared reasonably. (author)

Analyzing the history of Cognition using Topic Models.

Science.gov (United States)

Cohen Priva, Uriel; Austerweil, Joseph L

2015-02-01

Very few articles have analyzed how cognitive science as a field has changed over the last six decades. We explore how Cognition changed over the last four decades using Topic Models. Topic Models assume that every word in every document is generated by one of a limited number of topics. Words that are likely to co-occur are likely to be generated by a single topic. We find a number of significant historical trends: the rise of moral cognition, eyetracking methods, and action, the fall of sentence processing, and the stability of development. We introduce the notion of framing topics, which frame content, rather than present the content itself. These framing topics suggest that over time Cognition turned from abstract theorizing to more experimental approaches. Copyright © 2014 Elsevier B.V. All rights reserved.

Efficacy of Topical Alpha Ointment (Containing Natural Henna Compared to Topical Hydrocortisone (1% in the Healing of Radiation-Induced Dermatitis in Patients with Breast Cancer: A Randomized Controlled Clinical Trial

Directory of Open Access Journals (Sweden)

Mansour Ansari

2013-12-01

Full Text Available Background: This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1% in the healing of radiation-induced dermatitis in breast cancer patients. Methods: The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy] and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30 or topical hydrocortisone cream (1% (control arm, n=30 immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. Results: The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm2 in the control arm and 17.02 cm2 in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1% (P=0.001. This effect was significant in the second week (P=0.007. In addition, Alpha ointment decreased the patients’ complaints such as pain (P<0.001, pruritus (P=0.009, and discharge (P=0.010 effectively and meaningfully. Conclusion: Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1% in our patients with breast cancer. Trial Registration Numbers: IRCT201206099979N1 ACTRN12612000837820

Efficacy of topical alpha ointment (containing natural henna) compared to topical hydrocortisone (1%) in the healing of radiation-induced dermatitis in patients with breast cancer: a randomized controlled clinical trial.

Science.gov (United States)

Ansari, Mansour; Farzin, Dehsara; Mosalaei, Ahmad; Omidvari, Shapour; Ahmadloo, Niloofar; Mohammadianpanah, Mohammad

2013-12-01

This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1%) in the healing of radiation-induced dermatitis in breast cancer patients. The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy]) and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30) or topical hydrocortisone cream (1%) (control arm, n=30) immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm(2) in the control arm and 17.02 cm(2) in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) (P=0.001). This effect was significant in the second week (P=0.007). In addition, Alpha ointment decreased the patients' complaints such as pain (P<0.001), pruritus (P=0.009), and discharge (P=0.010) effectively and meaningfully. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) in our patients with breast cancer. IRCT201206099979N1, ACTRN12612000837820.

Topics of Bioengineering in Wikipedia

Directory of Open Access Journals (Sweden)

Vassia Atanassova

2009-10-01

Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

Natural and artificial radionuclides in our environment

International Nuclear Information System (INIS)

Neu, Alfred; Bayer, Anton; Steinkopff, Thomas

2010-01-01

The conference proceedings cover contributions and posters concerning the following topics: emission control and monitoring, environmental radioactivity and radiation exposure; radon in the environment; radioecology and modeling: radioecology and tracer for environmental processes, modeling in environmental monitoring, environmental and geostatistics; physical metrology and radiochemical methods; regulations, regulatory standards and quality assurance.

Long-term management of radioactive waste. Ethics and the environment

International Nuclear Information System (INIS)

Pescatore, C.

1999-01-01

The protection of the environment and the ethical issues that it raises are important topics in the debate on the long-term management of radioactive waste. An overview of the general ethical principles developed in the wider context of the debate on the environment is presented and the specific case of the management of long-lived radioactive waste is addressed. (author)

Landscape sensitivity in a dynamic environment

Science.gov (United States)

Lin, Jiun-Chuan; Jen, Chia-Horn

2010-05-01

Landscape sensitivity at different scales and topics is presented in this study. Methodological approach composed most of this paper. According to the environmental records in the south eastern Asia, the environment change is highly related with five factors, such as scale of influence area, background of environment characters, magnitude and frequency of events, thresholds of occurring hazards and influence by time factor. This paper tries to demonstrate above five points from historical and present data. It is found that landscape sensitivity is highly related to the degree of vulnerability of the land and the processes which put on the ground including human activities. The scale of sensitivity and evaluation of sensitivities is demonstrated in this paper by the data around east Asia. The methods of classification are mainly from the analysis of environmental data and the records of hazards. From the trend of rainfall records, rainfall intensity and change of temperature, the magnitude and frequency of earthquake, dust storm, days of draught, number of hazards, there are many coincidence on these factors with landscape sensitivities. In conclusion, the landscape sensitivities could be classified as four groups: physical stable, physical unstable, unstable, extremely unstable. This paper explain the difference.

Updates of Topical and Local Anesthesia Agents.

Science.gov (United States)

Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

2016-04-01

As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. Copyright © 2016 Elsevier Inc. All rights reserved.

Factors related to the design and implementation of an 'design for environment' process

DEFF Research Database (Denmark)

Skelton, Kristen; Knitl, Teresa

2013-01-01

In the last two decades, Siemens AG has systematically built up the topic of environmental protection within its core functions. The company is currently expanding its focus by including additional product and supply related environmental activities to enable strategic and inclusive decisions. Most...... recently, the Energy Sector of Siemens AG developed a Design for Environment (DfE) process based on ISO/TR 14062 to integrate environmental issues into product design and development. This paper briefly presents the DfE process and the feedback that was gathered from engineers as input to improve...

Sea-floor morphology and sedimentary environments in southern Narragansett Bay, Rhode Island

Science.gov (United States)

McMullen, Katherine Y.; Poppe, Lawrence J.; Blackwood, Dann S.; Nardi, Matthew J.; Andring, Matthew A.

2015-09-09

Multibeam echosounder data collected by the National Oceanic and Atmospheric Administration along with sediment samples and still and video photography of the sea floor collected by the U.S. Geological Survey were used to interpret sea-floor features and sedimentary environments in southern Narragansett Bay, Rhode Island, as part of a long-term effort to map the sea floor along the northeastern coast of the United States. Sea-floor features include rocky areas and scour depressions in high-energy environments characterized by erosion or nondeposition, and sand waves and megaripples in environments characterized by coarse-grained bedload transport. Two shipwrecks are also located in the study area. Much of the sea floor is relatively featureless within the resolution of the multibeam data; sedimentary environments in these areas are characterized by processes associated with sorting and reworking. This report releases bathymetric data from the multibeam echosounder, grain-size analyses of sediment samples, and photographs of the sea floor and interpretations of the sea-floor features and sedimentary environments. It provides base maps that can be used for resource management and studies of topics such as benthic ecology, contaminant inventories, and sediment transport.

Anesthesia: A Topic for Interdisciplinary Study.

Science.gov (United States)

Labianca, Dominick A.; Reeves, William J.

1977-01-01

Describes an interdisciplinary approach for teaching the topic of anesthesia as one aspect of a chemistry-oriented course for nonscience majors which focuses on timely topics such as the energy crisis and drugs. Historical treatment with the examination of literature is emphasized in teaching. (HM)

Sensory Media: Multidisciplinary Approaches in Designing a Situated & Mobile Learning Environment for Past Topics

Directory of Open Access Journals (Sweden)

Terje Rasmussen

2012-07-01

Full Text Available Handheld digital devices are rapidly increasing their sensory capabilities for registering multiple types of input, such as movement, orientation, position and touch, as well as light and sound. Mobile Augmented Rreality is one of the emerging forms of representation and expression that exploits these sensory media. In the following text we will present and discuss a type of indirect augmented reality, which we call situated simulations. In a situated simulation there is approximate identity between the 3D environment displayed on the screen and the user's real perspective on a given location. This makes it possible to create simulations of relevant objects and environments related to a specific place, for example, interpretations of its past. We present a situated simulation

Assessment of the effectiveness of topical propranolol 4% gel for infantile hemangiomas.

Science.gov (United States)

Mashiah, Jacob; Kutz, Ana; Rabia, Smail Hadj; Ilan, Efrat Bar; Goldberg, Ilan; Sprecher, Eli; Harel, Avikam

2017-02-01

Infantile hemangiomas (IHs) are the most common vascular tumors in children. Because of their benign character and natural involution, the vast majority of IHs do not require any treatment. In the past few years, topical beta blockers have been reported to be an effective treatment of superficial IHs. We sought to evaluate the clinical effectiveness and safety profile of topical propranolol 4% gel for the treatment of IHs. A retrospective study of all cases of IHs treated with topical propranolol 4% gel between 2013 and 2015 was performed. All patients were evaluated in a pediatric dermatology unit of a tertiary medical center. Epidemiologic, clinical, and treatment data, including effectiveness score and safety, were reviewed. The study included 63 patients with a total of 75 IHs. Of the total number of IHs, 43 (57.3%) showed a good response to treatment, 19 (25.3%) a partial response, and 13 (17.33%) poor or no response, thus 62 (82.6%) had good or partial response to treatment. Age at treatment initiation, treatment time, thickness of the superficial component, and size of the lesions were shown to predict response to therapy. Out of the entire examined group, only two patients reported minor local side effects manifested by irritation, redness, and scaling of the treated area. No systemic adverse effects were reported. This is an uncontrolled retrospective study. Propranolol 4% gel is a safe and efficient topical therapy for IH. © 2017 The International Society of Dermatology.

Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments.

Science.gov (United States)

Yasukochi, Yumi; Nakahara, Takeshi; Abe, Takeru; Kido-Nakahara, Makiko; Kohda, Futoshi; Takeuchi, Satoshi; Hagihara, Akihito; Furue, Masutaka

2014-09-01

Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients with atopic dermatitis (AD) and sensitively reflect short-term changes in skin conditions. The main treatment for AD is topical agent application. This study investigated the relationship between serum TARC levels and the dosage of topical agents, including corticosteroids and/or tacrolimus, in patients with AD. The serum TARC levels of 56 AD patients and the amounts of topical agents prescribed to them were investigated retrospectively. The weekly reduction in serum TARC levels and weekly dosage of topical agents among AD patients were compared and their associations were evaluated. The dosage of topical agents was closely related to serum TARC levels. One gram of strong rank steroid or the equivalent amount of steroid/tacrolimus is required to reduce serum TARC levels by 9.94 pg/mL weekly in moderate to severe AD patients. Higher initial TARC levels require more topical agent, which results in a more rapid decrease in TARC levels. The serum TARC levels and eosinophil numbers in peripheral blood are significantly correlated. Serum TARC level improvement and topical agent dosage are strongly correlated. TARC and eosinophil numbers are significantly correlated, but the wider range of TARC levels seems to be clinically more useful for monitoring AD severity. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD.

Studies of volatiles and organic materials in early terrestrial and present-day outer solar system environments

Science.gov (United States)

Sagan, Carl; Thompson, W. Reid; Chyba, Christopher F.; Khare, B. N.

1991-01-01

A review and partial summary of projects within several areas of research generally involving the origin, distribution, chemistry, and spectral/dielectric properties of volatiles and organic materials in the outer solar system and early terrestrial environments are presented. The major topics covered include: (1) impact delivery of volatiles and organic compounds to the early terrestrial planets; (2) optical constants measurements; (3) spectral classification, chemical processes, and distribution of materials; and (4) radar properties of ice, hydrocarbons, and organic heteropolymers.

The Greening of Pesticide–Environment Interactions: Some Personal Observations

Science.gov (United States)

2012-01-01

Background: Pesticide–environment interactions are bidirectional. The environment alters pesticides by metabolism and photodegradation, and pesticides in turn change the environment through nontarget or secondary effects. Objectives: Approximately 900 currently used commercial pesticides of widely diverse structures act by nearly a hundred mechanisms to control insects, weeds, and fungi, usually with minimal disruption of nature’s equilibrium. Here I consider some aspects of the discovery, development, and use of ecofriendly or green pesticides (i.e., pesticides that are safe, effective, and biodegradable with minimal adverse secondary effects on the environment). Emphasis is given to research in my laboratory. Discussion: The need for understanding and improving pesticide–environment interactions began with production of the first major insecticide approximately 150 years ago: The arsenical poison Paris Green was green in color but definitely not ecofriendly. Development and use of other pesticides has led to a variety of problems. Topics considered here include the need for high purity [e.g., hexachlorocyclohexane and polychloroborane isomers and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)], environmental degradation and the bioactivity of resulting photoproducts and metabolites, pesticide photochemistry (including the use of structural optimization, photostabilizers, and photosensitizers to achieve suitable persistence), the presence of multiple active ingredients in botanical insecticides, the need to consider compounds with common mechanisms of action, issues related to primary and secondary targets, and chemically induced or genetically modified changes in plant biochemistry. Many insecticides are bird, fish, and honeybee toxicants, whereas herbicides and fungicides pose fewer environmental problems. Conclusion: Six factors have contributed to the greening of pesticide–environment interactions: advances in pesticide chemistry and toxicology, banning

An Analysis of Research Topics within a Community : the Example of Knowledge Science

OpenAIRE

NIE, Kun; JI, Zhe; NAKAMORI, Yoshiteru

2007-01-01

This Paper presents a new approach how to analyze research topics within a given research community. Under the guidance of the I-system methodology, this paper conducts both top-down and bottom-up analysis. For the bottom-up analysis, similarity measurement and hierarchical clustering are applied to obtain a tree-like dendrogram structure of research topics; for the top-down analysis, the experts' knowledge is included. Then resulting from the iterative dialogue between the above two stages o...

Topical Session on Liabilities identification and long-term management at national level - Topical Session held during the 36. Meeting of the RWMC

International Nuclear Information System (INIS)

2003-01-01

These proceedings cover a topical session that was held at the March 2003 meeting of the Radioactive Waste Management Committee. The topical session focused on liability assessment and management for decommissioning of all types of nuclear installations, including decontamination of historic sites and waste management, as applicable. The presentations covered the current, national situations. The first oral presentation, from Switzerland, set the scene by providing a broad coverage of the relevant issues. The subsequent presentations - five from Member countries and one from the EC - described additional national positions and the evolving EC proposed directives. Each oral presentation was followed by a brief period of Q and As for clarification only. A plenary discussion took place on the ensemble of presentations and a Rapporteur provided a report on points made and lessons learnt. Additionally, written contributions were provided by RWMC delegates from several other countries. These are included in the proceedings as are the papers from the oral sessions, and the Rapporteur's report. These papers are not intended to be exhaustive, but to give an informed glimpse of NEA countries' approaches to liability identification and management in the context of nuclear facilities decommissioning and dismantling

Topical thrombin-related corneal calcification.

Science.gov (United States)

Kiratli, Hayyam; Irkeç, Murat; Alaçal, Sibel; Söylemezoğlu, Figen

2006-09-01

To report a highly unusual case of corneal calcification after brief intraoperative use of topical thrombin. A 44-year-old man underwent sclerouvectomy for ciliochoroidal leiomyoma, during which 35 UNIH/mL lyophilized bovine thrombin mixed with 9 mL of diluent containing 1500 mmol/mL calcium chloride was used. From the first postoperative day, corneal and anterior lenticular capsule calcifications developed, and corneal involvement slightly enlarged thereafter. A year later, 2 corneal punch biopsies confirmed calcification mainly in the Bowman layer. Topical treatment with 1.5% ethylenediaminetetraacetic acid significantly restored corneal clarity. Six months later, a standard extracapsular cataract extraction with intraocular lens placement improved visual acuity to 20/60. This case suggests that topical thrombin drops with elevated calcium concentrations may cause acute corneal calcification in Bowman layer and on the anterior lens capsule.

Multi Canister Overpack (MCO) Topical Report [SEC 1 THRU 6

International Nuclear Information System (INIS)

GARVIN, L.J.

2002-01-01

In February 1995, the US. Department of Energy (DOE) approved the Spent Nuclear Fuel (SNF) Project's ''Path Forward'' recommendation for resolution of the safety and environmental concerns associated with the deteriorating SNF stored in the Hanford Site's K Basins (Hansen 1995). The recommendation included an aggressive series of projects to design, construct, and operate systems and facilities to permit the safe retrieval, packaging, transport, conditioning, and interim storage of the K Basins' SNF. The facilities are the Cold Vacuum Drying Facility (CVDF) in the 100 K Area of the Hanford Site and the Canister Storage Building (CSB) in the 200 East Area. The K Basins' SNF is to be cleaned, repackaged in multi-canister overpacks (MCOs), removed from the K Basins, and transported to the CVDF for drying. The MCOs would then be moved to the CSB and weld sealed (Loscoe 1996) for interim storage (about 40 years). One of the major tasks associated with the initial Path Forward activities is the development and maintenance of the safety documentation. In addition to meeting the construction needs for new structures, the safety documentation for each must be generated. A common thread that was identified among the structures was the MCO. Each structure exists for the specific purpose of treating or storing the MCO and its contents. Normally, an extensive amount of MCO-related documentation would be generated for each of the facility safety analysis reports. However, the expedited schedule for removing spent fuel from the K Basins requires that the documentation effort be minimized and repetitious activities be eliminated. Therefore, this topical report has been prepared to address those aspects of the MCO that will be common to the facilities. The MCO will be included in each facility's safety documentation by reference to this topical report. By capturing the design of the MCO and its safety evaluation in a single document, repetition, inconsistency, and duplication of

Web-Scale Discovery Services Retrieve Relevant Results in Health Sciences Topics Including MEDLINE Content

Directory of Open Access Journals (Sweden)

Elizabeth Margaret Stovold

2017-06-01

Full Text Available A Review of: Hanneke, R., & O’Brien, K. K. (2016. Comparison of three web-scale discovery services for health sciences research. Journal of the Medical Library Association, 104(2, 109-117. http://dx.doi.org/10.3163/1536-5050.104.2.004 Abstract Objective – To compare the results of health sciences search queries in three web-scale discovery (WSD services for relevance, duplicate detection, and retrieval of MEDLINE content. Design – Comparative evaluation and bibliometric study. Setting – Six university libraries in the United States of America. Subjects – Three commercial WSD services: Primo, Summon, and EBSCO Discovery Service (EDS. Methods – The authors collected data at six universities, including their own. They tested each of the three WSDs at two data collection sites. However, since one of the sites was using a legacy version of Summon that was due to be upgraded, data collected for Summon at this site were considered obsolete and excluded from the analysis. The authors generated three questions for each of six major health disciplines, then designed simple keyword searches to mimic typical student search behaviours. They captured the first 20 results from each query run at each test site, to represent the first “page” of results, giving a total of 2,086 total search results. These were independently assessed for relevance to the topic. Authors resolved disagreements by discussion, and calculated a kappa inter-observer score. They retained duplicate records within the results so that the duplicate detection by the WSDs could be compared. They assessed MEDLINE coverage by the WSDs in several ways. Using precise strategies to generate a relevant set of articles, they conducted one search from each of the six disciplines in PubMed so that they could compare retrieval of MEDLINE content. These results were cross-checked against the first 20 results from the corresponding query in the WSDs. To aid investigation of overall

Nurse burnout and the working environment.

Science.gov (United States)

O'Mahony, Nuria

2011-09-01

This article examines levels of burnout experienced by emergency nurses and the characteristics of their work environment to determine if there is a relationship between the two. A literature review of recent articles on emergency nurses' burnout and contributing factors was undertaken. A quantitative study, in which nurses were asked to indicate the extent of their agreement with a series of statements on burnout and the working environment, was then undertaken, and the results were analysed to ascertain the extent to which the two topic are related. The results indicate that 52 per cent of nurses in an emergency department in Ireland experience high levels of emotional exhaustion and depersonalisation, which are significantly related to the nature of their work environment. Improvements to the environment and to education are required to reduce the risk of nurses developing burnout in the future.

Hazardous materials in aquatic environments of the Mississippi River Basin. Quarterly project status report, July 1, 1994--September 30, 1994

International Nuclear Information System (INIS)

1994-01-01

This document references information pertaining to the presence of hazardous materials in the Mississippi River Basin. Topics discussed include: The biological fate, transport, and ecotoxicity of toxic and hazardous wastes; biological uptake and metabolism; sentinels of aquatic contamination; bioremediation; microorganisms; biomarkers of exposure and ecotoxicity; expert geographical information systems for assessing hazardous wastes in aquatic environments; and enhancement of environmental education at Tulane and Xavier

Quality of the working environment and productivity : research findings and case studies

NARCIS (Netherlands)

Greef, M. de; Broek, K. van den; Jongkind, R.; Kenny, L.; Shechtman, O.; Kuhn, K.

2004-01-01

The purpose of this working paper, prepared by the Topic Centre on Research - Work and Health of the European Agency for Safety and Health at Work, is to look at the link between a good working environment and productivity. A better understanding of positive effects of a good working environment

Topics in the Journal of Counseling Psychology, 1963-2015.

Science.gov (United States)

Oh, JungSu; Stewart, Alan E; Phelps, Rosemary E

2017-11-01

Historical trends in a scientific field should be apparent in the changing content of journal articles over time. Using a topic modeling approach, a statistical method for quantifying the thematic content of text, 70 topics were extracted from the abstracts of 3,603 articles published in the Journal of Counseling Psychology from 1963 to 2015. After examining interpretability of 70 topics derived from the model, 64 meaningful topics and their trends were named. In addition, the authors also classified some of the related topics into 4 categories-counseling process and outcome, multiculturalism, research methodology, and vocational psychology. Counseling process and outcome related topics have decreased recently, while topics relating to multiculturalism and diversity have shown increasing trends. The authors also discussed trends that were observed and tried to account for the changing frequencies of some important research topics within these categories. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Topics in Bayesian statistics and maximum entropy

International Nuclear Information System (INIS)

Mutihac, R.; Cicuttin, A.; Cerdeira, A.; Stanciulescu, C.

1998-12-01

Notions of Bayesian decision theory and maximum entropy methods are reviewed with particular emphasis on probabilistic inference and Bayesian modeling. The axiomatic approach is considered as the best justification of Bayesian analysis and maximum entropy principle applied in natural sciences. Particular emphasis is put on solving the inverse problem in digital image restoration and Bayesian modeling of neural networks. Further topics addressed briefly include language modeling, neutron scattering, multiuser detection and channel equalization in digital communications, genetic information, and Bayesian court decision-making. (author)

Computer-based Role Playing Game Environment for Analogue Electronics

Directory of Open Access Journals (Sweden)

Lachlan M MacKinnon

2009-02-01

Full Text Available An implementation of a design for a game based virtual learning environment is described. The game is developed for a course in analogue electronics, and the topic is the design of a power supply. This task can be solved in a number of different ways, with certain constraints, giving the students a certain amount of freedom, although the game is designed not to facilitate trial-and-error approach. The use of storytelling and a virtual gaming environment provides the student with the learning material in a MMORPG environment.

Extracting Hot spots of Topics from Time Stamped Documents

Science.gov (United States)

Chen, Wei; Chundi, Parvathi

2011-01-01

Identifying time periods with a burst of activities related to a topic has been an important problem in analyzing time-stamped documents. In this paper, we propose an approach to extract a hot spot of a given topic in a time-stamped document set. Topics can be basic, containing a simple list of keywords, or complex. Logical relationships such as and, or, and not are used to build complex topics from basic topics. A concept of presence measure of a topic based on fuzzy set theory is introduced to compute the amount of information related to the topic in the document set. Each interval in the time period of the document set is associated with a numeric value which we call the discrepancy score. A high discrepancy score indicates that the documents in the time interval are more focused on the topic than those outside of the time interval. A hot spot of a given topic is defined as a time interval with the highest discrepancy score. We first describe a naive implementation for extracting hot spots. We then construct an algorithm called EHE (Efficient Hot Spot Extraction) using several efficient strategies to improve performance. We also introduce the notion of a topic DAG to facilitate an efficient computation of presence measures of complex topics. The proposed approach is illustrated by several experiments on a subset of the TDT-Pilot Corpus and DBLP conference data set. The experiments show that the proposed EHE algorithm significantly outperforms the naive one, and the extracted hot spots of given topics are meaningful. PMID:21765568

Karoo biome: a preliminary sythesis. Part 1 - physical environment

CSIR Research Space (South Africa)

Cowling, RM

1986-01-01

Full Text Available . It is a multi-authored publication covering a wide range of topics. This first volume summarizes what is currently known on the physical environment of the biome; namely geology, soils, climate, hydrology, geohydrology and soil erosion. Other aspects...

The role of imagination in experiencing natural environments

Science.gov (United States)

Herbert. Schroeder

2010-01-01

The experience of natural environments and places is multifaceted, involving psychological functions such as perception, cognition, memory, emotion, and imagination. Environmental perception and cognition were key topics in early research in environmental psychology. More recently, attention has also been directed to affective dimensions of environmental experience,...

Topics in supergravity and string theory

International Nuclear Information System (INIS)

Eastaugh, A.G.

1987-01-01

The first topic covered in this dissertation concerns the harmonic expansion technique and its application to the dimensional compactification of higher dimensional supergravity. A simple example is given to explain the method and then the method is applied to the problem of obtaining the mass spectrum of the squashed seven-sphere compactification of eleven dimensional supergravity. The second topic concerns the application of Fujikawa's method of anomaly calculation to the calculation of the critical dimension of various string models. The third topic is a study and explicit calculation of the Fock space representation of the vertex in Witten's formulation of the interacting open bosonic string field theory

The impacts of fracking on the environment: A total environmental study paradigm.

Science.gov (United States)

Meng, Qingmin

2017-02-15

Fracking has become a hot topic in the media and public discourse not only because of its economic benefit but also its environmental impacts. Recently, scientists have investigated the environmental impacts of fracking, and most studies focus on its air and ground water pollution. A systematic research structure and an overall evaluation of fracking's impacts on the environment are needed, because fracking does not only influence ground water but most environmental elements including but not limited to air, water, soil, rock, vegetation, wildlife, human, and many other ecosystem components. From the standpoint of the total environment, this communication assesses the overall impacts of fracking on the environment and then designs a total environmental study paradigm that effectively examines the complicated relationship among the total environment. Fracking dramatically changes the anthroposphere, which in turn significantly impacts the atmosphere, hydrosphere, lithosphere, and biosphere through the significant input or output of water, air, liquid or solid waste disposals, and the complex chemical components in fracking fluids. The proposed total environment study paradigm of fracking can be applied to other significant human activities that have dramatic impacts on the environment, such as mountain top coal mining or oil sands for environmental studies. Copyright © 2016 Elsevier B.V. All rights reserved.

Salicylic Acid Topical

Science.gov (United States)

... the package label for more information.Apply a small amount of the salicylic acid product to one or two small areas you want to treat for 3 days ... know that children and teenagers who have chicken pox or the flu should not use topical salicylic ...

Efficacy and safety of combinations of first-line topical treatments in chronic plaque psoriasis: a systematic literature review

NARCIS (Netherlands)

Hendriks, A.G.M.; Keijsers, R.R.M.C.; Jong, E.M.G.J. de; Seyger, M.M.B.; Kerkhof, P.C.M. van de

2013-01-01

Background Most psoriasis patients suffering from mild to moderate disease are treated with first-line topical treatments, including corticosteroids, vitamin D analogues, topical retinoids and calcineurin inhibitors. Although evidence-based guidelines on combinations are lacking, the majority of

Microplastics in aquatic environments: Implications for Canadian ecosystems.

Science.gov (United States)

Anderson, Julie C; Park, Bradley J; Palace, Vince P

2016-11-01

Microplastics have been increasingly detected and quantified in marine and freshwater environments, and there are growing concerns about potential effects in biota. A literature review was conducted to summarize the current state of knowledge of microplastics in Canadian aquatic environments; specifically, the sources, environmental fate, behaviour, abundance, and toxicological effects in aquatic organisms. While we found that research and publications on these topics have increased dramatically since 2010, relatively few studies have assessed the presence, fate, and effects of microplastics in Canadian water bodies. We suggest that efforts to determine aquatic receptors at greatest risk of detrimental effects due to microplastic exposure, and their associated contaminants, are particularly warranted. There is also a need to address the gaps identified, with a particular focus on the species and conditions found in Canadian aquatic systems. These gaps include characterization of the presence of microplastics in Canadian freshwater ecosystems, identifying key sources of microplastics to these systems, and evaluating the presence of microplastics in Arctic waters and biota. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

COMPARATIVE STUDY OF TOPICAL MOMETASONE FUROATE 0.1%, TOPICAL 0.03% TACROLIMUS, TOPICAL BASIC FIBROBLAST GROWTH FACTOR (bFGF IN CHILDHOOD VITILIGO

Directory of Open Access Journals (Sweden)

Kavitha S. B

2017-08-01

Full Text Available BACKGROUND Vitiligo, the commonest of all pigmentary disorders, is an idiopathic, acquired cutaneous achromia, characterised by circumscribed, chalky white macules. It may also involve the pigment epithelium of the eyes, the inner ear and the leptomeninges. Although, vitiligo can begin at any age, it develops before the age of 20 years in 50% of the patients and before the age of 10 years in 25% of patients. MATERIALS AND METHODS The study was conducted for a period of one year with 6 months active intervention. A group of 60 consecutive children attending the outpatient Department of Dermatology were included in this study. The same patients were acting as controls. RESULTS Grade 4 response was seen in 12 cases (60% who were on mometasone (VV-20%, focal-30%, segmental-10%, in 10 cases (50% on tacrolimus (VV-20%, focal-30% and in 4 cases (20% on bFGF (focal. Lesions on the face and neck showed grade 4 response in 16 cases (mometasone-8, tacrolimus-6 and bFGF-2, extremities in 6 cases. On the whole grade, 4 response was observed more with mometasone (60% followed by tacrolimus (50%. Grade 3 response was observed with bFGF (30%. CONCLUSION Topical mometasone was very effective among the 3 drugs used in childhood vitiligo showing grade 4 repigmentation in all types of vitiligo except mucosal vitiligo. Tacrolimus proved almost as effective as mometasone to restore skin colour in lesions of vitiligo in children. Because it does not produce atrophy or other adverse effects, tacrolimus may be very useful for younger patients, and for sensitive areas of the skin such as eyelids, it should be considered in other skin disorders currently treated with topical steroids for prolonged periods. Topical basic fibroblast growth factor though less effective than mometasone and tacrolimus, but can be tried as initial therapy in resistant cases such as segmental vitiligo as initial therapy of small vitiligo patches when physicians may not like to initiate high risk

The efficacy of topical tranexamic acid in total hip arthroplasty: a meta-analysis.

Science.gov (United States)

Chen, Shubiao; Wu, Kezhou; Kong, Gengbin; Feng, Weili; Deng, Zhihua; Wang, Hu

2016-02-16

Topical tranexamic acid (TXA) has been shown to be effective in reducing blood loss and the need for transfusion after total knee arthroplasty. However, the effectiveness of topical TXA use in total hip arthroplasty (THA) still remains unclear. The purpose of this meta-analysis is to examine the safety and efficacy of topical use of TXA following THA. Topical TXA reduces blood loss and transfusion rates without increasing risk of deep vein thrombosis in patients with THA. An electronic literature search of PubMed, Embase, the Cochrane Library, Web of Science and Chinese Biomedical Database was performed, to identify studies published before February 2015. All randomized controlled trials and cohort studies evaluating the efficacy of topical TXA during THA were included. Two independent authors identified the eligible studies, assessed their methodological quality, and extracted data. The data were using fixed-effects or random-effects models with (standard) mean differences and risk ratios for continuous and dichotomous variables, respectively. Data were analysed using RevMan 5.3 software. Fourteen studies encompassing 2594 patients met the inclusion criteria for our meta-analysis. Our meta-analysis indicated that when compared with the placebo group, topical use of TXA significantly reduced total blood loss (MD = -297.65 ml, 95 % CI -371.68 ml, 116.08 ml; P level (SMD = -0.66, 95 % CI -0.91, -0.41; P Topical TXA could significantly reduce total blood loss, drainage loss, transfusion rates and decrease haemoglobin level following THA, without increasing risk of venous thromboembolisms.

Using Facebook as an informal learning environment.

Science.gov (United States)

Cain, Jeff; Policastri, Anne

2011-12-15

To create, implement, and assess the effectiveness of an optional Facebook activity intended to expose students to contemporary business issues not covered in the core content of a pharmacy management and leadership course and to perspectives of experts and thought leaders external to their university. An informal learning strategy was used to create a Facebook group page and guest experts were identified and invited to submit posts pertaining to business-related topics. Students were given instructions for joining the Facebook group but informed that participation was optional. A mixed-methods approach using a student questionnaire, results on examination questions, and a student focus group was used to assess this activity. The informal design with no posting guidelines and no participation requirement was well received by students, who appreciated the unique learning environment and exposure to external experts. Facebook provides an informal learning environment for presenting contemporary topics and the thoughts of guest experts not affiliated with a college or school, thereby exposing students to relevant "real world" issues.

Topical report review status. Volume 9, No. 1

International Nuclear Information System (INIS)

1995-02-01

This report provides industry with procedures for submitting topical reports, guidance on how the US Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review by the NRC. This report is published semiannually

Topic models: A novel method for modeling couple and family text data

Science.gov (United States)

Atkins, David C.; Rubin, Tim N.; Steyvers, Mark; Doeden, Michelle A.; Baucom, Brian R.; Christensen, Andrew

2012-01-01

Couple and family researchers often collect open-ended linguistic data – either through free response questionnaire items or transcripts of interviews or therapy sessions. Because participant's responses are not forced into a set number of categories, text-based data can be very rich and revealing of psychological processes. At the same time it is highly unstructured and challenging to analyze. Within family psychology analyzing text data typically means applying a coding system, which can quantify text data but also has several limitations, including the time needed for coding, difficulties with inter-rater reliability, and defining a priori what should be coded. The current article presents an alternative method for analyzing text data called topic models (Steyvers & Griffiths, 2006), which has not yet been applied within couple and family psychology. Topic models have similarities with factor analysis and cluster analysis in that topic models identify underlying clusters of words with semantic similarities (i.e., the “topics”). In the present article, a non-technical introduction to topic models is provided, highlighting how these models can be used for text exploration and indexing (e.g., quickly locating text passages that share semantic meaning) and how output from topic models can be used to predict behavioral codes or other types of outcomes. Throughout the article a collection of transcripts from a large couple therapy trial (Christensen et al., 2004) is used as example data to highlight potential applications. Practical resources for learning more about topic models and how to apply them are discussed. PMID:22888778

School environment and school type as correlates of secondary ...

African Journals Online (AJOL)

Indiscipline among secondary school students has been the topic of most intellectual debates worldwide because it's adverse effects on educational achievement and performance. This research therefore examines the influence of school types and school environment (facilities) on students' disciplinary behavior in some ...

Yearly scientific meeting: chemistry in human health and environment protection. Bialystok'92

International Nuclear Information System (INIS)

1992-01-01

The conference has been divided into 12 sections devoted to following topics: analytical chemistry; environmental chemistry; chemistry of natural compounds; chemistry of pharmaceutics and toxic compounds; chemistry in medicine; electrochemistry; young scientists forum; didactics and history of chemistry; chemistry and industry - technologies environment friendly; new trends in polymer science; crystallochemistry; pro-ecological actions in leather industry. Different analytical methods for determination of heavy methods and rare earths have been presented. Some of them have been successfully applied for the examination of environmental and biological materials. The basic chemical and physico-chemical studies including thermodynamic, crystal structure, coordination chemistry, sorption properties etc. have been extensively resented. The existence of radioactive elements in environment has been also investigated, especially in respect to municipal and industrial wastes and products of their processing. The radiation effects for different materials have been reported and discussed as well

Preface to Special Topic: Marine Renewable Energy

Energy Technology Data Exchange (ETDEWEB)

Pinto, F. T.; Iglesias, G.; Santos, P. R.; Deng, Zhiqun

2015-12-30

Marine renewable energy (MRE) is generates from waves, currents, tides, and thermal resources in the ocean. MRE has been identified as a potential commercial-scale source of renewable energy. This special topic presents a compilation of works selected from the 3rd IAHR Europe Congress, held in Porto, Portugal, in 2014. It covers different subjects relevant to MRE, including resource assessment, marine energy sector policies, energy source comparisons based on levelized cost, proof-of-concept and new-technology development for wave and tidal energy exploitation, and assessment of possible inference between wave energy converters (WEC).

Quercetin topical application, from conventional dosage forms to nanodosage forms.

Science.gov (United States)

Hatahet, T; Morille, M; Hommoss, A; Devoisselle, J M; Müller, R H; Bégu, S

2016-11-01

Skin is a multifunctional organ with activities in protection, metabolism and regulation. Skin is in a continuous exposure to oxidizing agents and inflammogens from the sun and from the contact with the environment. These agents may overload the skin auto-defense capacity. To strengthen skin defense mechanisms against oxidation and inflammation, supplementation of exogenous antioxidants is a promising strategy. Quercetin is a flavonoid with very pronounced effective antioxidant and antiinflammatory activities, and thus a candidate of first choice for such skin supplementation. Quercetin showed interesting actions in cellular and animal based models, ranging from protecting cells from UV irradiation to support skin regeneration in wound healing. However, due to its poor solubility, quercetin has limited skin penetration ability, and various formulation approaches were taken to increase its dermal penetration. In this article, the quercetin antioxidant and antiinflammatory activities in wound healing and supporting skin against aging are discussed in detail. In addition, quercetin topical formulations from conventional emulsions to novel nanoformulations in terms of skin penetration enhancement are also presented. This article gives a comprehensive review of quercetin for topical application from biological effects to pharmaceutical formulation design for the last 25 years of research. Copyright © 2016 Elsevier B.V. All rights reserved.

Proceedings of the Topical Session on Applying Decommissioning Experience to the Design and Operation of New Nuclear Power Plants. Topical Session of the 9. Meeting of the WPDD Held in Senec, Slovak Republic 12-13 November 2008

International Nuclear Information System (INIS)

Noviello, Luigi; O'Sullivan, Patrick; Laurent, Gerard; Tuomisto, Harri; Metcalfe, Doug; Duncan, Allan

2009-01-01

At its ninth meeting, the WPDD held a topical session on Applying Decommissioning Experience to the Design and Operation of New Plants. In preparation for this, a survey was issued to reactor design organisations, electricity producers and safety authorities and responses were compiled into a summary report that provided a basis for discussion at the topical session. This report is in two parts: Part A documents the topical session, summarising the main points from the presentations and discussions and including the rapporteurs' reports. Part B provides a summary compilation of the responses received to the survey undertaken prior to the topical session. The topical session facilitated an exchange of information and experience between policy makers, regulators, electricity producers, design organisations and decommissioners on approaches and experiences to taking account of decommissioning considerations in the design of third generation reactor systems

Topical treatment of psoriasis: questionnaire results on topical therapy accessibility and influence of body surface area on usage

NARCIS (Netherlands)

Iversen, L.; Lange, M.M. De; Bissonette, R.; Carvalho, A.V.E.; Kerkhof, P.C.M. van de; Kirby, B.; Kleyn, C.E.; Lynde, C.W.; Walt, J.M. van der; Wu, J.J.

2017-01-01

BACKGROUND: Topical treatment of mild to moderate psoriasis is first-line treatment and exhibits varying degrees of success across patient groups. Key factors influencing treatment success are physician topical treatment choice (high efficacy, low adverse events) and strict patient adherence.

Hot topics: Signal processing in acoustics

Science.gov (United States)

Gaumond, Charles F.

2005-09-01

Signal processing in acoustics is a multidisciplinary group of people that work in many areas of acoustics. We have chosen two areas that have shown exciting new applications of signal processing to acoustics or have shown exciting and important results from the use of signal processing. In this session, two hot topics are shown: the use of noiselike acoustic fields to determine sound propagation structure and the use of localization to determine animal behaviors. The first topic shows the application of correlation on geo-acoustic fields to determine the Greens function for propagation through the Earth. These results can then be further used to solve geo-acoustic inverse problems. The first topic also shows the application of correlation using oceanic noise fields to determine the Greens function through the ocean. These results also have utility for oceanic inverse problems. The second topic shows exciting results from the detection, localization, and tracking of marine mammals by two different groups. Results from detection and localization of bullfrogs are shown, too. Each of these studies contributed to the knowledge of animal behavior. [Work supported by ONR.

Topical Valproate Solution for Hair Growth

Directory of Open Access Journals (Sweden)

Anil Kakunje

2018-05-01

Full Text Available Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis and off label in many other conditions. Alopecia or hair loss is cosmetic side effect of oral valproate administration. Hair loss with valproate is diffused, non-scarring and dose related. A large number of drugs may interfere with the hair cycle and produce hair loss. We have only a few drugs like Minoxidil, Finasteride used for hair regeneration and both have its own side effects and limitations. In contrast to oral ingestions of valproate causing hair loss, early experiments with topical Valproic acid cream showed hair regeneration. Valproic acid cream is currently unavailable in the market, alternatively, we do have valproate and divalproex solutions available in various strengths which have a potential to be used topically for hair regeneration. The side effects and cost of topical valproate solution could be much less than the available options in the market. Valproate solution topically has the potential to be used for hair growth.

NATO Advanced Study Institute on Optical Waveguide Sensing and Imaging in Medicine, Environment, Security and Defence

CERN Document Server

Bock, Wojtek J; Tanev, Stoyan

2008-01-01

The book explores various aspects of existing and emerging fiber and waveguide optics sensing and imaging technologies including recent advances in nanobiophotonics. The focus is both on fundamental and applied research as well as on applications in civil engineering, biomedical sciences, environment, security and defence. The main goal of the multi-disciplinarry team of Editors was to provide an useful reference of state-of-the-art overviews covering a variety of complementary topics on the interface of engineering and biomedical sciences.

Evaluating topic model interpretability from a primary care physician perspective.

Science.gov (United States)

Arnold, Corey W; Oh, Andrea; Chen, Shawn; Speier, William

2016-02-01

Probabilistic topic models provide an unsupervised method for analyzing unstructured text. These models discover semantically coherent combinations of words (topics) that could be integrated in a clinical automatic summarization system for primary care physicians performing chart review. However, the human interpretability of topics discovered from clinical reports is unknown. Our objective is to assess the coherence of topics and their ability to represent the contents of clinical reports from a primary care physician's point of view. Three latent Dirichlet allocation models (50 topics, 100 topics, and 150 topics) were fit to a large collection of clinical reports. Topics were manually evaluated by primary care physicians and graduate students. Wilcoxon Signed-Rank Tests for Paired Samples were used to evaluate differences between different topic models, while differences in performance between students and primary care physicians (PCPs) were tested using Mann-Whitney U tests for each of the tasks. While the 150-topic model produced the best log likelihood, participants were most accurate at identifying words that did not belong in topics learned by the 100-topic model, suggesting that 100 topics provides better relative granularity of discovered semantic themes for the data set used in this study. Models were comparable in their ability to represent the contents of documents. Primary care physicians significantly outperformed students in both tasks. This work establishes a baseline of interpretability for topic models trained with clinical reports, and provides insights on the appropriateness of using topic models for informatics applications. Our results indicate that PCPs find discovered topics more coherent and representative of clinical reports relative to students, warranting further research into their use for automatic summarization. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Topics on continua

CERN Document Server

Macias, Sergio

2005-01-01

Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

Microemulsion and Microemulsion-Based Gels for Topical Antifungal Therapy with Phytochemicals.

Science.gov (United States)

Boonme, Prapaporn; Kaewbanjong, Jarika; Amnuaikit, Thanaporn; Andreani, Tatiana; Silva, Amélia M; Souto, Eliana B

2016-01-01

Skin fungal infections are regular injuries suffered by people living in tropical areas. Most common pathogens are Trichophyton, Microsporum and Epidermophyton which can cause skin lesions in many parts of body. Topical antifungal phytochemicals are commonly used to avoid systemic adverse events and are more convenient for patient application than those administered by other routes. However, the effectiveness of topical treatments in eradicating fungal infection is more limited since the stratum corneum acts as the skin barrier, resulting in long treatment duration and low patient's compliance. The goal of this work is to identify optimized drug delivery systems to improve topic clinical efficacy. Microemulsions i.e. liquid dispersions of oil and water stabilized with an interfacial film of surfactant are well known drug delivery systems. A thickening agent may be included to form microemulsion-based gels to increase skin adhesion. Microemulsions and microemulsion-based gels can be loaded with several hydrophilic and lipophilic drugs because they are composed of both water and oil phases. Microemulsions and microemulsion-based gels can also be used for the delivery of many drugs including antifungal drugs through stratum corneum due to their capacity to act as skin penetration enhancement. In addition to a comprehensive review of microemulsion and microemulsion-based gels as suitable carriers for skin delivery of various antifungal drugs, this review also aims to discuss the delivery of antifungal phytochemicals.

15th International Conference on Man–Machine–Environment System Engineering

CERN Document Server

Dhillon, Balbir

2015-01-01

This research topic was first established in China by Professor ShengZhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, XueSen Qian. In a letter to ShengZhao Long from October 22nd, 1993, XueSen Qian wrote: “You have created a very important modern science subject and technology in China!” MMESE primarily focuses on the relationship between Man, Machine and Environment, studying the optimum combination of man-machine-environment systems. In this system, “Man” refers to working people as the subject in the workplace (e.g. operators, decision-makers); “Machine” is the general name for any object controlled by Man (including tools, machinery, computers, systems and technologies), and “Environment” describes the specific working conditions under which Man and Machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization are to ensure safety, efficiency and economy. These proceedings are an academic showcase of t...

EDITORIAL: International Workshop on Current Topics in Monte Carlo Treatment Planning

Science.gov (United States)

Verhaegen, Frank; Seuntjens, Jan

2005-03-01

The use of Monte Carlo particle transport simulations in radiotherapy was pioneered in the early nineteen-seventies, but it was not until the eighties that they gained recognition as an essential research tool for radiation dosimetry, health physics and later on for radiation therapy treatment planning. Since the mid-nineties, there has been a boom in the number of workers using MC techniques in radiotherapy, and the quantity of papers published on the subject. Research and applications of MC techniques in radiotherapy span a very wide range from fundamental studies of cross sections and development of particle transport algorithms, to clinical evaluation of treatment plans for a variety of radiotherapy modalities. The International Workshop on Current Topics in Monte Carlo Treatment Planning took place at Montreal General Hospital, which is part of McGill University, halfway up Mount Royal on Montreal Island. It was held from 3-5 May, 2004, right after the freezing winter has lost its grip on Canada. About 120 workers attended the Workshop, representing 18 countries. Most of the pioneers in the field were present but also a large group of young scientists. In a very full programme, 41 long papers were presented (of which 12 were invited) and 20 posters were on display during the whole meeting. The topics covered included the latest developments in MC algorithms, statistical issues, source modelling and MC treatment planning for photon, electron and proton treatments. The final day was entirely devoted to clinical implementation issues. Monte Carlo radiotherapy treatment planning has only now made a slow entrée in the clinical environment, taking considerably longer than envisaged ten years ago. Of the twenty-five papers in this dedicated special issue, about a quarter deal with this topic, with probably many more studies to follow in the near future. If anything, we hope the Workshop served as an accelerator for more clinical evaluation of MC applications. The

Topical cholesterol in clofazimine induced ichthyosis

Directory of Open Access Journals (Sweden)

Pandey S

1994-01-01

Full Text Available Topical application of 10% cholesterol in petrolatum significantly (P< 0.05 controlled the development of ichthyosis in 62 patients taking 100 mg clofazimine daily for a period of 3 months. However, topical cholesterol application did not affect the lowering of serum cholesterol induced by oral clofazimine. Probable mechanism of action is being discussed.

Topical antibiotic monotherapy prescribing practices in acne vulgaris.

Science.gov (United States)

Hoover, William D; Davis, Scott A; Fleischer, Alan B; Feldman, Steven R

2014-04-01

The aim of this study is to evaluate the frequency of dosing topical antibiotics as monotherapy in the treatment of acne vulgaris, and physician specialty prescribing these medications. This study is a retrospective review of all visits with a sole diagnosis of acne vulgaris (ICD-9-CM code 706.1) found on the National Ambulatory Medical Care Survey (NAMCS) in 1993-2010. We recorded the number of visits surveyed where acne vulgaris was the sole diagnosis, number of visits where topical antibiotics were the only treatment prescribed, and the specialty of physician in each encounter. Topical erythromycin or clindamycin were the sole medication prescribed in 0.81% of the visits recorded, with 60% of these prescriptions arising from dermatologists and 40% from non-dermatologists. The trend of prescribing topical antibiotic monotherapy is declining (p acnes to topical antibiotic regimens has led to the need to re-evaluate the use of topical antibiotics in the treatment of acne vulgaris. While the rate of topical antibiotic monotherapy is declining, their use should be reserved for situations where the direct need for antibiotics arises. If a clinician feels that antibiotics are a necessary component to acne therapy, they should be used as part of a combination regimen.

Topical tacrolimus for atopic dermatitis.

Science.gov (United States)

Cury Martins, Jade; Martins, Ciro; Aoki, Valeria; Gois, Aecio F T; Ishii, Henrique A; da Silva, Edina M K

2015-07-01

Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they can be associated with significant adverse effects when used chronically. Tacrolimus ointment (in its 2 manufactured strengths of 0.1% and 0.03%) might be an alternative treatment. Tacrolimus, together with pimecrolimus, are drugs called topical calcineurin inhibitors (TCIs). To assess the efficacy and safety of topical tacrolimus for moderate and severe atopic dermatitis compared with other active treatments. We searched the following databases up to 3 June 2015: the Cochrane Skin Group Specialised Register, CENTRAL in the Cochrane Library (Issue 5, 2015), MEDLINE (from 1946), EMBASE (from 1974), LILACS (from 1982), and the Global Resource of Eczema Trials (GREAT database). We searched six trials registers and checked the bibliographies of included studies for further references to relevant trials. We contacted specialists in the field for unpublished data.A separate search for adverse effects of topical tacrolimus was undertaken in MEDLINE and EMBASE on 30 July 2013. We also scrutinised the U.S. Food and Drug Administration (FDA) websites for adverse effects information. All randomised controlled trials (RCTs) of participants with moderate to severe atopic dermatitis (both children and adults) using topical tacrolimus at any dose, course duration, and follow-up time compared with other active treatments. Two authors independently screened and examined the full text of selected studies for compliance with eligibility criteria, risk of bias, and data extraction. Our three prespecified primary outcomes were physician's assessment, participant's self-assessment of improvement, and adverse effects. Our secondary outcomes included assessment of improvement of the disease by validated or objective measures, such as

Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial.

Science.gov (United States)

Bissonnette, R; Papp, K A; Poulin, Y; Gooderham, M; Raman, M; Mallbris, L; Wang, C; Purohit, V; Mamolo, C; Papacharalambous, J; Ports, W C

2016-11-01

Despite unmet need, 15 years have passed since a topical therapy with a new mechanism of action for atopic dermatitis (AD) has been approved. Janus kinase (JAK) inhibitor treatment effect via topical application in patients with AD is unknown. Tofacitinib, a small-molecule JAK inhibitor, was investigated for the topical treatment of AD. In this 4-week, phase IIa, randomized, double-blind, vehicle-controlled study (NCT02001181), 69 adults with mild-to-moderate AD were randomized 1:1 to 2% tofacitinib or vehicle ointment twice daily. Percentage change from baseline (CFB) in Eczema Area and Severity Index (EASI) score at week 4 was the primary end point. Secondary efficacy end points included percentage CFB in body surface area (BSA), CFB in EASI Clinical Signs Severity Sum Score, proportion of patients with Physician's Global Assessment (PGA) response and CFB in patient-reported pruritus. Safety, local tolerability and pharmacokinetics were monitored. The mean percentage CFB at week 4 in EASI score was significantly greater (P tofacitinib (-81·7%) vs. vehicle (-29·9%). Patients treated with tofacitinib showed significant (P tofacitinib. Tofacitinib ointment showed significantly greater efficacy vs. vehicle across end points, with early onset of effect and comparable safety/local tolerability to vehicle. JAK inhibition through topical delivery is potentially a promising therapeutic target for AD. © 2016 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.

Baby Health Checkup: MedlinePlus Health Topic

Science.gov (United States)

... Know (Centers for Disease Control and Prevention) - PDF Topic Image MedlinePlus Email Updates Get Baby Health Checkup ... GO MEDICAL ENCYCLOPEDIA Well-child visits Related Health Topics Childhood Immunization Common Infant and Newborn Problems Infant ...

Laser Eye Surgery: MedlinePlus Health Topic

Science.gov (United States)

... corneal surgery - discharge (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Laser Eye Surgery ... surgery - what to ask your doctor Related Health Topics Refractive Errors National Institutes of Health The primary ...

Child Mental Health: MedlinePlus Health Topic

Science.gov (United States)

... events and children (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Child Mental Health ... in childhood Traumatic events and children Related Health Topics Bullying Child Behavior Disorders Mental Disorders Mental Health ...

Bone Marrow Transplantation: MedlinePlus Health Topic

Science.gov (United States)

... marrow transplant - discharge (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Bone Marrow Transplantation ... transplant - slideshow Graft-versus-host disease Related Health Topics Bone Marrow Diseases Stem Cells National Institutes of ...

Nutrition for Seniors: MedlinePlus Health Topic

Science.gov (United States)

... America) National Institute on Aging Also in Spanish Topic Image MedlinePlus Email Updates Get Nutrition for Seniors updates by email What's this? GO Related Health Topics Nutrition Seniors' Health National Institutes of Health The ...

Blood Count Tests: MedlinePlus Health Topic

Science.gov (United States)

... Spanish WBC count (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Blood Count Tests ... WBC count Show More Show Less Related Health Topics Bleeding Disorders Blood Laboratory Tests National Institutes of ...

Hormone Replacement Therapy: MedlinePlus Health Topic

Science.gov (United States)

... of hormone therapy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Hormone Replacement Therapy ... Estrogen overdose Types of hormone therapy Related Health Topics Menopause National Institutes of Health The primary NIH ...

Atom probe field ion microscopy and related topics: A bibliography 1993

Energy Technology Data Exchange (ETDEWEB)

Godfrey, R.D.; Miller, M.K.; Russell, K.F.

1994-10-01

This bibliography, covering the period 1993, includes references related to the following topics: atom probe field ion microscopy (APFIM), field emission (FE), and field ion microscopy (FIM). Technique-oriented studies and applications are included. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications. To reduce the length of this document, the references have been reduced to the minimum necessary to locate the articles. The references are listed alphabetically by authors, an Addendum of references missed in previous bibliographies is included.

Atom probe field ion microscopy and related topics: A bibliography 1993

International Nuclear Information System (INIS)

Godfrey, R.D.; Miller, M.K.; Russell, K.F.

1994-10-01

This bibliography, covering the period 1993, includes references related to the following topics: atom probe field ion microscopy (APFIM), field emission (FE), and field ion microscopy (FIM). Technique-oriented studies and applications are included. The references contained in this document were compiled from a variety of sources including computer searches and personal lists of publications. To reduce the length of this document, the references have been reduced to the minimum necessary to locate the articles. The references are listed alphabetically by authors, an Addendum of references missed in previous bibliographies is included

Experimental model of the burn wound topical treatment

Directory of Open Access Journals (Sweden)

Amra Čabaravdić

2003-11-01

Full Text Available AbstractBACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burninducement and effects of the ointment containing natural plants on the process of burn healing.MATERIAL AND METHODS:Burn wounds were experimentally induced in two species of experimental animals which were treated with topically applied herbal preparation with concomitant monitoring of the healing process. Experimental groups (1 of 15 animals each (mice and rats, while control group (2 of 10 animals each (mice and rats that were not being treated with herbal ointment. After the hair removal, burn was induced on the back of animals by heated brass seal. Different clinical symptoms including oedema of surrounding tissue, redness, exudation, size of the burn surface, histological and microbiological findings were monitored on the days 1, 3, 7, 14 and 21. A statistically significant difference was observed throughout descriptive statistics and paired Student's t-test.CONCLUSION:Physiological healing processes of the acute burn wound following the topical application of herbal preparation can be monitored on the utilized animal model. A three-week treatment resulted in the 90% of completed epithelization in both animal species, indicating the effectiveness of topically applied herbal preparation.

Composition for the treatment of radiation sickness and topical bacterial infections

International Nuclear Information System (INIS)

Gaffin, S.L.

1985-01-01

A therapeutic composition for the theatment of radiation sickness comprises a carrier medium including one or more antibodies specific to gram negative bacteria chosen from the group Klebsiella, Pseudomoneas, Shigella, Salmonella and Escherichia species is discussed. The composition may by formed for oral administration or topical application

Editorial: Advancing the Debate on Architecture, Planning, and Built Environment Research

Directory of Open Access Journals (Sweden)

Ashraf M. Salama

2015-07-01

This edition of IJAR: volume 9, issue 2, July 2015 includes debates on a wide spectrum of issues, explorations and investigations in various settings. The issue encompasses sixteen papers addressing cities, settlements, and projects in Europe, South East Asia, and the Middle East. Papers involve international collaborations evidenced by joint contributions and come from scholars in universities, academic institutions, and practices in Belgium; Egypt; Greece; Italy; Jordan; Malaysia; Palestine; Qatar; Saudi Arabia; Serbia; Spain; Turkey; and the United Kingdom. In this editorial I briefly outline the key issues presented in these papers, which include topics relevant to social housing, multigenerational dwelling, practice-based research, sustainable design and biomimetic models, learning environments and learning styles, realism and the post modern condition, development and planning, urban identity, contemporary landscapes, and cultural values and traditions.

Kinematic/Dynamic Characteristics for Visual and Kinesthetic Virtual Environments

Science.gov (United States)

Bortolussi, Michael R. (Compiler); Adelstein, B. D.; Gold, Miriam

1996-01-01

Work was carried out on two topics of principal importance to current progress in virtual environment research at NASA Ames and elsewhere. The first topic was directed at maximizing the temporal dynamic response of visually presented Virtual Environments (VEs) through reorganization and optimization of system hardware and software. The final results of this portion of the work was a VE system in the Advanced Display and Spatial Perception Laboratory at NASA Ames capable of updating at 60 Hz (the maximum hardware refresh rate) with latencies approaching 30 msec. In the course of achieving this system performance, specialized hardware and software tools for measurement of VE latency and analytic models correlating update rate and latency for different system configurations were developed. The second area of activity was the preliminary development and analysis of a novel kinematic architecture for three Degree Of Freedom (DOF) haptic interfaces--devices that provide force feedback for manipulative interaction with virtual and remote environments. An invention disclosure was filed on this work and a patent application is being pursued by NASA Ames. Activities in these two areas are expanded upon below.

Energy, society and environment. Technology for a sustainable future

International Nuclear Information System (INIS)

Elliott, D.

1997-04-01

Energy, Society and Environment examines energy and energy use, and the interactions between technology, society and the environment. The book is clearly structured to examine; Key environmental issues, and the harmful impacts of energy use; New technological solutions to environmental problems; Implementation of possible solutions, and Implications for society in developing a sustainable approach to energy use. Social processes and strategic solutions to problems are located within a clear, technological context with topical case studies. (UK)

The Impact of Topic Interest, L2 Proficiency, and Gender on EFL Incidental Vocabulary Acquisition through Reading

Science.gov (United States)

Lee, Sunjung; Pulido, Diana

2017-01-01

This study investigated the impact of topic interest, alongside L2 proficiency and gender, on L2 vocabulary acquisition through reading. A repeated-measures design was used with 135 Korean EFL students. Control variables included topic familiarity, prior target-word knowledge, and target-word difficulty (word length, class, and concreteness).…

Topical report review status. Volume 7, No. 2

International Nuclear Information System (INIS)

1984-11-01

Purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the NRC staff review has been completed and those which are under review and to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions are deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility

Does topical tranexamic acid reduce postcoronary artery bypass graft bleeding?

Directory of Open Access Journals (Sweden)

Amir Mirmohammadsadeghi

2018-01-01

Full Text Available Background: Postoperative bleeding is a common problem in cardiac surgery. We tried to evaluate the effect of topical tranexamic acid (TA on reducing postoperative bleeding of patients undergoing on-pump coronary artery bypass graft (CABG surgery. Materials and Methods: One hundred and twenty-six isolated primary CABG patients were included in this clinical trial. They were divided blindly into two groups; Group 1, patients receiving 1 g TA diluted in 100 ml normal saline poured into mediastinal cavity before closing the chest and Group 2, patients receiving 100 ml normal saline at the end of operation. First 24 and 48 h chest tube drainage, hemoglobin decrease and packed RBC transfusion needs were compared. Results: Both groups were the same in baseline characteristics including gender, age, body mass index, ejection fraction, clamp time, bypass time, and operation length. During the first 24 h postoperatively, mean chest tube drainage in intervention group was 567 ml compared to 564 ml in control group (P = 0.89. Mean total chest tube drainage was 780 ml in intervention group and 715 ml in control group (P = 0.27. There was no significant difference in both mean hemoglobin decrease (P = 0.26 and packed RBC transfusion (P = 0.7. Topical application of 1 g TA diluted in 100 ml normal saline does not reduce postoperative bleeding of isolated on-pump CABG surgery. Conclusion: We do not recommend topical usage of 1 g TA diluted in 100 ml normal saline for decreasing blood loss in on-pump CABG patients.

Selected topics in nuclear structure

Energy Technology Data Exchange (ETDEWEB)

Solov` ev, V G; Gromov, K Ya; Malov, L A; Shilov, V M

1994-12-31

The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles). heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and {beta}-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei.

Topics in current aerosol research

CERN Document Server

Hidy, G M

1971-01-01

Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

Selected topics in nuclear structure

International Nuclear Information System (INIS)

Solov'ev, V.G.; Gromov, K.Ya.; Malov, L.A.; Shilov, V.M.

1994-01-01

The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles. heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and β-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei

The Physics of Semiconductors An Introduction Including Devices and Nanophysics

CERN Document Server

Grundmann, Marius

2006-01-01

The Physics of Semiconductors provides material for a comprehensive upper-level-undergrauate and graduate course on the subject, guiding readers to the point where they can choose a special topic and begin supervised research. The textbook provides a balance between essential aspects of solid-state and semiconductor physics, on the one hand, and the principles of various semiconductor devices and their applications in electronic and photonic devices, on the other. It highlights many practical aspects of semiconductors such as alloys, strain, heterostructures, nanostructures, that are necessary in modern semiconductor research but typically omitted in textbooks. For the interested reader some additional advanced topics are included, such as Bragg mirrors, resonators, polarized and magnetic semiconductors are included. Also supplied are explicit formulas for many results, to support better understanding. The Physics of Semiconductors requires little or no prior knowledge of solid-state physics and evolved from ...

Environment and energy

International Nuclear Information System (INIS)

Wirkner, H.; Kneller, P.

1981-01-01

FACIT is a periodical intended to provide the reader with a survey of outstanding publications on topical subjects. At the same time, it offers a first insight into the subject field, enabling the reader to select among the literature cited the publications he may need to enhance his knowledge and information. The periodical is aimed at serving as a guide to the complex variety of publications in a subject field, and to offer information in brief. Vol. 1, Environment and Energy, cites representative statements and samples from the German-language literature in this field and gives hints for further reading. (orig./HSCH) [de

Application of computational fluid dynamics in building performance simulation for the outdoor environment: an overview

NARCIS (Netherlands)

Blocken, B.J.E.; Stathopoulos, T.; Carmeliet, J.; Hensen, J.L.M.

2011-01-01

This paper provides an overview of the application of CFD in building performance simulation for the outdoor environment, focused on four topics: (1) pedestrian wind environment around buildings, (2) wind-driven rain on building facades, (3) convective heat transfer coefficients at exterior building

Dressings and topical agents for treating pressure ulcers.

Science.gov (United States)

Westby, Maggie J; Dumville, Jo C; Soares, Marta O; Stubbs, Nikki; Norman, Gill

2017-06-22

Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many options to choose from including alginate, hydrocolloid and protease-modulating dressings. Topical agents have also been used as alternatives to dressings in order to promote healing.A clear and current overview of all the evidence is required to facilitate decision-making regarding the use of dressings or topical agents for the treatment of pressure ulcers. Such a review would ideally help people with pressure ulcers and health professionals assess the best treatment options. This review is a network meta-analysis (NMA) which assesses the probability of complete ulcer healing associated with alternative dressings and topical agents. To assess the effects of dressings and topical agents for healing pressure ulcers in any care setting. We aimed to examine this evidence base as a whole, determining probabilities that each treatment is the best, with full assessment of uncertainty and evidence quality. In July 2016 we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta-analyses, guidelines and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting. Published or unpublished randomised controlled trials (RCTs) comparing the effects of at least one of the following interventions with any other intervention in the treatment of pressure ulcers (Stage 2 or above): any dressing, or any topical agent applied directly

Topics in atomic physics

CERN Document Server

Burkhardt, Charles E

2006-01-01

The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

Game controller modification for fMRI hyperscanning experiments in a cooperative virtual reality environment.

Science.gov (United States)

Trees, Jason; Snider, Joseph; Falahpour, Maryam; Guo, Nick; Lu, Kun; Johnson, Douglas C; Poizner, Howard; Liu, Thomas T

2014-01-01

Hyperscanning, an emerging technique in which data from multiple interacting subjects' brains are simultaneously recorded, has become an increasingly popular way to address complex topics, such as "theory of mind." However, most previous fMRI hyperscanning experiments have been limited to abstract social interactions (e.g. phone conversations). Our new method utilizes a virtual reality (VR) environment used for military training, Virtual Battlespace 2 (VBS2), to create realistic avatar-avatar interactions and cooperative tasks. To control the virtual avatar, subjects use a MRI compatible Playstation 3 game controller, modified by removing all extraneous metal components and replacing any necessary ones with 3D printed plastic models. Control of both scanners' operation is initiated by a VBS2 plugin to sync scanner time to the known time within the VR environment. Our modifications include:•Modification of game controller to be MRI compatible.•Design of VBS2 virtual environment for cooperative interactions.•Syncing two MRI machines for simultaneous recording.

Topics in Finance Part VII--Dividend Policy

Science.gov (United States)

Laux, Judy

2011-01-01

This series inspects the major topics in finance, reviewing the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts. The current article, devoted to dividend policy, also reviews the topic as presented in textbooks and the literature.

Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study.

Science.gov (United States)

Thomas, Kim S; Ormerod, Anthony D; Craig, Fiona E; Greenlaw, Nicola; Norrie, John; Mitchell, Eleanor; Mason, James M; Johnston, Graham A; Wahie, Shyamal; Williams, Hywel C

2016-11-01

Pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. We sought to estimate the effectiveness of topical therapies in the treatment of patients with PG. This was a prospective cohort study of UK secondary care patients with a clinical diagnosis of PG that was suitable for topical treatment (recruited between July 2009 and June 2012). Participants received topical therapy after normal clinical practice (primarily topical corticosteroids [classes I-III] and tacrolimus 0.03% or 0.1%). The primary outcome was speed of healing at 6 weeks. Secondary outcomes included the following: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality of life; treatment failure; and recurrence. Sixty-six patients (22-85 years of age) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28 of 66 (43.8%) ulcers healed by 6 months. The median time to healing was 145 days (95% confidence interval, 96 days to ∞). Initial ulcer size was a significant predictor of time to healing (hazard ratio, 0.94 [95% confidence interval, 0.88-1.00); P = .043). Four patients (15%) had a recurrence. Our study did not include a randomized comparator. Topical therapy is potentially an effective first-line treatment for PG that avoids the possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Topics in Nuclear Astrophysics

International Nuclear Information System (INIS)

Chung, K.C.

1982-01-01

Some topics in nuclear astrophysics are discussed, e.g.: highly evolved stellar cores, stellar evolution (through the temperature analysis of stellar surface), nucleosynthesis and finally the solar neutrino problem. (L.C.) [pt

TASS code topical report. V.1 TASS code technical manual

International Nuclear Information System (INIS)

Sim, Suk K.; Chang, W. P.; Kim, K. D.; Kim, H. C.; Yoon, H. Y.

1997-02-01

TASS 1.0 code has been developed at KAERI for the initial and reload non-LOCA safety analysis for the operating PWRs as well as the PWRs under construction in Korea. TASS code will replace various vendor's non-LOCA safety analysis codes currently used for the Westinghouse and ABB-CE type PWRs in Korea. This can be achieved through TASS code input modifications specific to each reactor type. The TASS code can be run interactively through the keyboard operation. A simimodular configuration used in developing the TASS code enables the user easily implement new models. TASS code has been programmed using FORTRAN77 which makes it easy to install and port for different computer environments. The TASS code can be utilized for the steady state simulation as well as the non-LOCA transient simulations such as power excursions, reactor coolant pump trips, load rejections, loss of feedwater, steam line breaks, steam generator tube ruptures, rod withdrawal and drop, and anticipated transients without scram (ATWS). The malfunctions of the control systems, components, operator actions and the transients caused by the malfunctions can be easily simulated using the TASS code. This technical report describes the TASS 1.0 code models including reactor thermal hydraulic, reactor core and control models. This TASS code models including reactor thermal hydraulic, reactor core and control models. This TASS code technical manual has been prepared as a part of the TASS code manual which includes TASS code user's manual and TASS code validation report, and will be submitted to the regulatory body as a TASS code topical report for a licensing non-LOCA safety analysis for the Westinghouse and ABB-CE type PWRs operating and under construction in Korea. (author). 42 refs., 29 tabs., 32 figs

Knowledge Sharing Practice in a Play-Like Learning Environment

DEFF Research Database (Denmark)

Benjaminsen, Nana

2007-01-01

The topic of this paper is play-like learning as it occurs when technology based learning environments is invited into the classroom. Observations of 5th grade classes playing with Lego Robolab, is used to illustrate that different ways of learning becomes visible when digital technology...

Educational Technology Research Journals: "Interactive Learning Environments," 2004-2013

Science.gov (United States)

Christensen, Steven S.; Andrews, Carolyn; Harris, Scott P.; Lloyd, Adam; Turley, Chad; West, Richard E.

2015-01-01

This study examined the journal "Interactive Learning Environments" to discover trends from 2004-2013. The authors looked at trends in article topics, research methods, authorship, citations, keyword frequencies, phrase counts of article abstracts, and article citations according to Google Scholar. Evidence is provided of the journal's…

INFLUENCE OF MARKETING ENVIRONMENT ON THE TOY MARKET

Directory of Open Access Journals (Sweden)

Violeta A. ANDREIANA (Mihaescu

2014-04-01

Full Text Available Along with the passage of time, parents have manifested a different attitude towards their children, trying to offer them everything they wanted in what concerns the toys. Therefore, the toy market is constantly expending, and the tough competition leads to the quality improvement of the toys and enforces certain standards on the market. The originality and topicality of the theme consist in the change in the toy consumers’ and users’ preferences which required greater attention to be paid to the influence manifested by the marketing environment on this market. The case study identifies the occurred problems and the toy influence factors by an analysis over the marketing environment components, i.e.: marketing internal environment, micro-environment and macro-environment. The study ends with the recommendation of several solutions for the improvement of the current situation.

Case Of Iatrogenic Cushing's Syndrome By Topical Triamcinolone.

Science.gov (United States)

Zil-E-Ali, Ahsan; Janjua, Omer Hanif; Latif, Aiza; Aadil, Muhammad

2018-01-01

Cushing's syndrome is a collection of signs and symptoms due to hypercortisolism. Prolong use of topical steroid may cause this syndrome and suppression of hypothalamic and pituitary function, however such events are more common with oral and parenteral route. There are very few cases of Cushing's syndrome with a topical application amongst which triamcinolone is the rarest drug. We report a case of 11-year-old boy is presented who developed Cushing's disease by topical application. The child had body rashes for which the caregiver consulted a local quack, a topical cream of triamcinolone was prescribed. After application for three months, the patient became obese and developed a moon-like face. A thorough biochemical workup and diagnostic test for Cushing's disease was done to confirm. The following case report a dramatic example of development of the syndrome from chronic topical application of the least potent corticosteroid.

Interpretable Topic Features for Post-ICU Mortality Prediction.

Science.gov (United States)

Luo, Yen-Fu; Rumshisky, Anna

2016-01-01

Electronic health records provide valuable resources for understanding the correlation between various diseases and mortality. The analysis of post-discharge mortality is critical for healthcare professionals to follow up potential causes of death after a patient is discharged from the hospital and give prompt treatment. Moreover, it may reduce the cost derived from readmissions and improve the quality of healthcare. Our work focused on post-discharge ICU mortality prediction. In addition to features derived from physiological measurements, we incorporated ICD-9-CM hierarchy into Bayesian topic model learning and extracted topic features from medical notes. We achieved highest AUCs of 0.835 and 0.829 for 30-day and 6-month post-discharge mortality prediction using baseline and topic proportions derived from Labeled-LDA. Moreover, our work emphasized the interpretability of topic features derived from topic model which may facilitates the understanding and investigation of the complexity between mortality and diseases.

Gathering by the Red Sea highlights links between environment and epigenetics

KAUST Repository

Li, Mo; Borrelli, Emiliana; Magistretti, Pierre J.; Izpisua Belmonte, Juan Carlos; Sassone-Corsi, Paolo; Orlando, Valerio

2017-01-01

, and how the environment may impinge on epigenetic control, are topics of growing debate. Those themes were the focus of the inaugural international King Abdullah University of Science and Technology (KAUST) Research Conference on Environmental Epigenetics

Exploring Topic Structure: Coherence, Diversity and Relatedness

NARCIS (Netherlands)

J. He (Jiyin)

2011-01-01

htmlabstractThe use of topical information has long been studied in the context of information retrieval. For example, grouping search results into topical categories enables more effective information presentation to users, while grouping documents in a collection can lead to efficient information

Selected Translated Abstracts of Chinese-Language Climate Change Publications; TOPICAL

International Nuclear Information System (INIS)

Cushman, R.M.; Burtis, M.D.

1999-01-01

This report contains English-translated abstracts of important Chinese-language literature concerning global climate change for the years 1995-1998. This body of literature includes the topics of adaptation, ancient climate change, climate variation, the East Asia monsoon, historical climate change, impacts, modeling, and radiation and trace-gas emissions. In addition to the biological citations and abstracts translated into English, this report presents the original citations and abstracts in Chinese. Author and title indexes are included to assist the reader in locating abstracts of particular interest

Topical Research: Africa.

Science.gov (United States)

Lynn, Karen

This lesson plan can be used in social studies, language arts, or library research. The instructional objective is for students to select a topic of study relating to Africa, write a thesis statement, collect information from media sources, and develop a conclusion. The teacher may assign the lesson for written or oral evaluation. The teacher…

Topic structure affects semantic integration: evidence from event-related potentials.

Science.gov (United States)

Yang, Xiaohong; Chen, Xuhai; Chen, Shuang; Xu, Xiaoying; Yang, Yufang

2013-01-01

This study investigated whether semantic integration in discourse context could be influenced by topic structure using event-related brain potentials. Participants read discourses in which the last sentence contained a critical word that was either congruent or incongruent with the topic established in the first sentence. The intervening sentences between the first and the last sentence of the discourse either maintained or shifted the original topic. Results showed that incongruent words in topic-maintained discourses elicited an N400 effect that was broadly distributed over the scalp while those in topic-shifted discourses elicited an N400 effect that was lateralized to the right hemisphere and localized over central and posterior areas. Moreover, a late positivity effect was only elicited by incongruent words in topic-shifted discourses, but not in topic-maintained discourses. This suggests an important role for discourse structure in semantic integration, such that compared with topic-maintained discourses, the complexity of discourse structure in topic-shifted condition reduces the initial stage of semantic integration and enhances the later stage in which a mental representation is updated.

Changes seen in the environment report from Uusimaa Regional Environment Centre

International Nuclear Information System (INIS)

Enckell, E.; Airola, H.; Tornivaara-Ruikka, R.; Villa, L.; Salasto, R.

2002-05-01

This publication describes the environmental changes and the influencing factors occurring within the administrative regions of the Uusimaa Regional Environment Centre. The quality of the environment can be judged as satisfying in regards to both the mental and physical health of humans. Areas have a steady trend of a relatively high growth in population density, while the efficiency of land use in new settlements is low. Traffic and the travel distances are on the rise. A considerable part of the population lives in areas where the noise standards are violated, despite control measures. Waste management, water distribution and sewage networks are under continuous development. In regards to the nature, the situation in some parts is of great concern. The manifold of the nature, cultural landscapes and culturally valuable buildings and sites are threatened. The living space of flora and fauna is continuing to decrease and change. The risks caused by human activities in groundwater areas are increasing. For these reasons the implementation of protection programs is important. Emissions from point sources to the water and air have significantly decreased. Yet, the impacts of air quality deprivation can still be seen in some cities and in the vicinity of some industrial sites. The eutrophication have essentially changed the ecology and fishstocks; however, the water quality has improved in many places. Regarding the above issues, as well as some other topics, included in the report are 16 theme maps 66 pictures. However, the report states that the monitoring and reporting of the environmental quality should be improved. (orig.)

Internal environment analysis and its improvement in company Ltd "German Products Baltics"

OpenAIRE

Štekels, Jānis

2012-01-01

The topic of the Bachelors work is „Internal environment analysis and its improvment in company Ltd „German Products Baltics””. The objective of Bachelors work is to explore and analyze the internal environment and to develop proposals for its improvement. Subject of the work is actual, because each company before starting its business or to change something in companies work, should understood the companies strength and weaknesses by analyzing internal environment. Bachelor work consists of ...

Uses of technology in lower secondary mathematics education : a concise topical survey

NARCIS (Netherlands)

Drijvers, P.H.M.; Ball, Lynda; Barzel, Barbel; Heid, M. Kathleen; Cao, Yiming; Maschietto, Michela

2016-01-01

This topical survey provides an overview of the current state of the art in technology use in mathematics education, including both practice-oriented experiences and research-based evidence, as seen from an international perspective. Three core themes are discussed: Evidence of effectiveness;

Diclofenac Topical (osteoarthritis pain)

Science.gov (United States)

... gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining ... Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a ...

Diclofenac Topical (actinic keratosis)

Science.gov (United States)

... topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by ... The way diclofenac gel works to treat actinic keratosis is not known.Diclofenac is also available as ...

Advances in energy and environment. Vol. 1: Energy

International Nuclear Information System (INIS)

El-Sharkawy, A.L.; Kummler, R.H.

1996-01-01

The 5th conference of energy and environment was held on 3-6 June 1996 in Cairo. The specialists discussed the effects of advances in energy and environment. The applications of solar energy, heat transfer, thermal application, storage and bio-conversion, fuels, energy and development. Studies were discussed at the meeting and more than 1000 papers were presented. This first volume covers papers presented on the following topics: solar thermal, heat transfer and thermal applications, storage and bio-conversion, refrigeration and iar conditioning, combustion, fuels and engines, energy and development. tabs., figs

Energy, Transport, & the Environment Addressing the Sustainable Mobility Paradigm

CERN Document Server

King, Sir

2012-01-01

Sustainable mobility is a highly complex problem as it is affected by the interactions between socio-economic, environmental, technological and political issues. Energy, Transport, & the Environment: Addressing the Sustainable Mobility Paradigm brings together leading figures from business, academia and governments to address the challenges and opportunities involved in working towards sustainable mobility. Key thinkers and decision makers approach topics and debates including:   ·         energy security and resource scarcity ·         greenhouse gas and pollutant emissions ·         urban planning, transport systems and their management ·         governance and finance of transformation ·         the threats of terrorism and climate change to our transport systems.   Introduced by a preface from U.S. Secretary Steven Chu and an outline by the editors, Dr Oliver Inderwildi and Sir David King, Energy, Transport, & the Environment is divided into six secti...

Current State of Nanomedicines in the Treatment of Topical Infectious Disorders.

Science.gov (United States)

Thakur, Kanika; Sharma, Gajanand; Singh, Bhupinder; Chhibber, Sanjay; Katare, Om Prakash

2018-05-28

Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives. The application of nanotechnology to medicine, or nanomedicine, is rapidly becoming a major driving force behind ongoing changes in the anti-infective field because of its interaction at the sub-atomic level with the skin tissue. The latter, in the current scenario, points towards vesicular carriers like liposomes, lipidic nanoparticles and silver nanoparticles etc. as the most promising drug delivery solutions for topical infection disorders. These have exhibited immense significance owing to their uniqueness to facilitate the interactions at interfaces with the barrier membranes. The present review summarizes the emerging efforts in combating topical infections particularly using nanomedicine based delivery systems as new tools to tackle the current challenges in treating infectious diseases. Besides, compiling various research reports, this article also includes formulation considerations, mechanisms of penetration and patents reported. Despite the new emerging technologies and delivery systems, efforts are still needed in the right direction to combat this global challenge. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Effect of Topical Cyclosporine in grading of Vernal keratoconjunctivitis.

Directory of Open Access Journals (Sweden)

Dr Krupali Raol

2017-06-01

Full Text Available Background & Objective: To evaluate efficacy of topical aqueous solution of 0.05% cyclosporine in first time diagnosed vernal keratoconjunctivitis (VKC including palpebral, bulbar and mixed form. Methods: 25 patients of VKC received CsA 0.05% aqueous ophthalmic solution in a dosage of one drop every 12 hours in both eyes for 6 months. Follow up visits (day 1, 2 weeks, 1 month, 2 months, 3 months and 6 months. Five symptoms were evaluated and six clinical signs were charted. Total objective score of 13 or more over atleast 3 variables was included (CART – scoring system. Results: Comparison of 1st Day with 2 weeks score showed no significant effect in the score value (t=0.90, df = 24, p<0.1. 1st Day with 3rd month score showed maximum effect in the score value (t = 35.76, df = 24, p<0.0001. 3rd month with 6th month score showed sustained effect of cyclosporine showing no major change in the score line (t test, t = 1.80, df = 24, p <0.05. Conclusion: Topical application of a 0.05% CsA aqueous solution has been shown to be effective in the treatment of patients with VKC. CsA could be an important alternative to steroid treatment.

iVFTs - immersive virtual field trips for interactive learning about Earth's environment.

Science.gov (United States)

Bruce, G.; Anbar, A. D.; Semken, S. C.; Summons, R. E.; Oliver, C.; Buxner, S.

2014-12-01

Innovations in immersive interactive technologies are changing the way students explore Earth and its environment. State-of-the-art hardware has given developers the tools needed to capture high-resolution spherical content, 360° panoramic video, giga-pixel imagery, and unique viewpoints via unmanned aerial vehicles as they explore remote and physically challenging regions of our planet. Advanced software enables integration of these data into seamless, dynamic, immersive, interactive, content-rich, and learner-driven virtual field explorations, experienced online via HTML5. These surpass conventional online exercises that use 2-D static imagery and enable the student to engage in these virtual environments that are more like games than like lectures. Grounded in the active learning of exploration, inquiry, and application of knowledge as it is acquired, users interact non-linearly in conjunction with an intelligent tutoring system (ITS). The integration of this system allows the educational experience to be adapted to each individual student as they interact within the program. Such explorations, which we term "immersive virtual field trips" (iVFTs), are being integrated into cyber-learning allowing science teachers to take students to scientifically significant but inaccessible environments. Our team and collaborators are producing a diverse suite of freely accessible, iVFTs to teach key concepts in geology, astrobiology, ecology, and anthropology. Topics include Early Life, Biodiversity, Impact craters, Photosynthesis, Geologic Time, Stratigraphy, Tectonics, Volcanism, Surface Processes, The Rise of Oxygen, Origin of Water, Early Civilizations, Early Multicellular Organisms, and Bioarcheology. These diverse topics allow students to experience field sites all over the world, including, Grand Canyon (USA), Flinders Ranges (Australia), Shark Bay (Australia), Rainforests (Panama), Teotihuacan (Mexico), Upheaval Dome (USA), Pilbara (Australia), Mid-Atlantic Ridge

Solid-State Lighting 2017 Suggested Research Topics Supplement: Technology and Market Context

Energy Technology Data Exchange (ETDEWEB)

None, None

2017-09-29

A 2017 update to the Solid-State Lighting R&D Plan that is divided into two documents. The first document describes a list of suggested SSL priority research topics and the second document provides context and background, including information drawn from technical, market, and economic studies. Widely referenced by industry and government both here and abroad, these documents reflect SSL stakeholder inputs on key R&D topics that will improve efficacy, reduce cost, remove barriers to adoption, and add value for LED and OLED lighting solutions over the next three to five years, and discuss those applications that drive and prioritize the specific R&D.

The 90s - The decade of the environment meeting the training challenge

International Nuclear Information System (INIS)

Worley, T.

1991-01-01

The decade of the 90s is the Decade of the Environment--you see it on TV, in papers, magazines... everywhere. Protection of the environment and compliance with new and ever-changing regulations are a must for companies to be successful. Like all other industries, utilities must meet this challenge head on. The nuclear industry has always been aware of the need for training on nuclear issues such as handling nuclear materials and wastes and responding to nuclear emergencies; but to meet the challenges of tomorrow, we must now provide quality training on environmental regulations. This paper outlines the process Duke Power is using to meet the challenge of providing consistent, accurate, relevant training on EPA, OSHA, and DOT regulations. Training programs discussed in this paper include: general employee environmental overview training; RCRA specific training topics; OSHA emergency response team training; and department of transportation training

Analysis of the Research Status and Topics on the Radionuclide Migration and Retardation in Natural Barriers

International Nuclear Information System (INIS)

Baik, Min Hoon; Park, Chung Kyun; Kim, Seung Soo; Lee, Seung Yeop; Lee, Jae Kwang

2008-12-01

In this report, recent research status for major developed countries in the high-level radioactive waste disposal including international organizations was investigated and analyzed in research topics for the radionuclide migration and retardation in natural barriers. Besides, recent research trends and future prospects were investigated for selected major 10 topics about the radionuclide migration and retardation processes. Based upon these investigations and analyses, future research goals and topics to be concentrated were presented. This report will be helpful for understanding our current research status and technical position and establishing future research direction and topics by analyzing domestic and foreign research status and trends. The results will also be utilized as basic information for establishing future policy and plans of the government for the high-level radioactive waste disposal

Analysis of the Research Status and Topics on the Radionuclide Migration and Retardation in Natural Barriers

Energy Technology Data Exchange (ETDEWEB)

Baik, Min Hoon; Park, Chung Kyun; Kim, Seung Soo; Lee, Seung Yeop; Lee, Jae Kwang [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-12-15

In this report, recent research status for major developed countries in the high-level radioactive waste disposal including international organizations was investigated and analyzed in research topics for the radionuclide migration and retardation in natural barriers. Besides, recent research trends and future prospects were investigated for selected major 10 topics about the radionuclide migration and retardation processes. Based upon these investigations and analyses, future research goals and topics to be concentrated were presented. This report will be helpful for understanding our current research status and technical position and establishing future research direction and topics by analyzing domestic and foreign research status and trends. The results will also be utilized as basic information for establishing future policy and plans of the government for the high-level radioactive waste disposal.

Digital Social Network Mining for Topic Discovery

Science.gov (United States)

Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.

Antimicrobial topical agents used in the vagina.

Science.gov (United States)

Frey Tirri, Brigitte

2011-01-01

Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effective against bacteria, fungi, viruses and protozoa. Topical treatments can be prescribed for a wide variety of vaginal infections. Many bacterial infections, such as bacterial vaginosis, desquamative inflammatory vaginitis or, as some European authors call it, aerobic vaginitis as well as infection with Staphylococcus aureus or group A streptococci, may be treated in this way. Candida vulvovaginitis is a fungal infection that is very amenable to topical treatment. The most common viral infections which can be treated with topical medications are condylomata acuminata and herpes simplex. The most often encountered protozoal vaginitis, which is caused by Trichomonas vaginalis, may be susceptible to topical medications, although this infection is treated systemically. This chapter covers the wide variety of commonly used topical antimicrobial agents for these diseases and focuses on the individual therapeutic agents and their clinical efficacy. In addition, potential difficulties that can occur in practice, as well as the usage of these medications in the special setting of pregnancy, are described in this chapter. Copyright © 2011 S. Karger AG, Basel.

Knowing and Using Your Environment. Environmental Education Curriculum.

Science.gov (United States)

Topeka Public Schools, KS.

This unit is intended to help students become aware of overall relationships and interactions that exist between the various segments of the environment. The unit consists of four topics: (1) Geology--The geological history of the earth as illustrated by fossils; (2) Plants and Animals--the role and interactions of plants and animals in the…

Efficacy and safety of topical tranexamic acid in knee arthroplasty.

Science.gov (United States)

López-Hualda, Álvaro; Dauder-Gallego, Cristina; Ferreño-Márquez, David; Martínez-Martín, Javier

2018-02-26

Tranexamic acid (TXA) is commonly used to control postoperative blood loss in total knee arthroplasty. In order to avoid adverse effects associated with intravenous administration, topical use has been proposed as an alternative. Our aim was to evaluate the efficacy and safety of topical TXA in total knee arthroplasty. A total of 90 patients scheduled for unilateral total knee arthroplasty were included in a prospective randomised study. All surgeries were performed under spinal anaesthesia, tourniquet and the same postoperative protocol. Patients were allocated to one of the 3 groups according to the application of TXA: group A (n=30) 1g of topical TXA; group B (n=30) 1g of TXA intravenous and in group C or the control group (n=30) no drug was administrated. Parameters related to blood loss and drain outputs were compared between the 3 groups. The results revealed that post-operative decrease in haemoglobin level was significantly lower in group A (1.95g/dL) than group B (2.25g/dL) and group C (2.96g/dL), P<.01. Total postoperative blood loss was lower in group A (195mL) than group B (466mL) and group C (718mL), P<.01. There was no significant difference in complications and allogenic blood transfusion rate between the 3 groups. According to the results, topical application of 1g TXA significantly reduced blood loss in patients undergoing total knee arthroplasty more than intravenous or no administration of TXA. Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures.

Science.gov (United States)

Ipema, Heather J; Tanzi, Maria G

2012-01-01

To evaluate the literature describing topical use of tranexamic acid or aminocaproic acid for prevention of postoperative bleeding after major surgical procedures. Literature was retrieved through MEDLINE (1946-September 2011) and International Pharmaceutical Abstracts (1970-September 2011) using the terms tranexamic acid, aminocaproic acid, antifibrinolytic, topical, and surgical. In addition, reference citations from publications identified were reviewed. All identified articles in English were evaluated. Clinical trials, case reports, and meta-analyses describing topical use of tranexamic acid or aminocaproic acid to prevent postoperative bleeding were included. A total of 16 publications in the setting of major surgical procedures were included; the majority of data were for tranexamic acid. For cardiac surgery, 4 trials used solutions containing tranexamic acid (1-2.5 g in 100-250 mL of 0.9% NaCl), and 1 trial assessed a solution containing aminocaproic acid (24 g in 250 mL of 0.9% NaCl). These solutions were poured into the chest cavity before sternotomy closure. For orthopedic procedures, all of the data were for topical irrigation solutions containing tranexamic acid (500 mg-3 g in 50-100 mL of 0.9% NaCl) or for intraarticular injections of tranexamic acid (250 mg to 2 g in 20-50 mL of 0.9% sodium chloride, with or without carbazochrome sodium sulfate). Overall, use of topical tranexamic acid or aminocaproic acid reduced postoperative blood loss; however, few studies reported a significant reduction in the number of packed red blood cell transfusions or units given, intensive care unit stay, or length of hospitalization. Topical application of tranexamic acid and aminocaproic acid to decrease postsurgical bleeding after major surgical procedures is a promising strategy. Further data are needed regarding the safety of this hemostatic approach.

Virtual reality and telepresence control of robots used in hazardous environments

International Nuclear Information System (INIS)

Bronisz, L.E.; Pittman, P.C.

1996-01-01

The purpose of this project was to explore the application of teleoperation and telepresence control to robots in hazardous environments at Los Alamos. The primary use of this technology would be in a glove-box type operation potentially allowing operators to work on hazardous materials while being completely removed from the danger of exposure in situations that are difficult to completely automate due to the highly unstructured environments or off-normal conditions. This project focused on determining the most appropriate tools and methods that could be applied in the near future resulting in a reasonably inexpensive working teleoperation or telepresence control system for industrial robots used in the handling of hazardous materials. Several topics had to be addressed to perform this task including input devices, control systems, robot manipulators, and simulation techniques or packages. Much of the work is still in the developmental stage and hardware will follow -- providing a usable tool for glove box robot control

Influence of input matrix representation on topic modelling performance

CSIR Research Space (South Africa)

De Waal, A

2010-11-01

Full Text Available Topic models explain a collection of documents with a small set of distributions over terms. These distributions over terms define the topics. Topic models ignore the structure of documents and use a bag-of-words approach which relies solely...

Agriculture 2008. The critical agrarian report. Main topic 2008: Agriculture as an energy producer; Landwirtschaft 2008. Der kritische Agrarbericht. Schwerpunkt 2008: Landwirtschaft als Energieerzeuger

Energy Technology Data Exchange (ETDEWEB)

Schneider, M.; Fink-Kessler, A.; Stodieck, F. (comps.)

2008-01-15

The focus of the critical agrarian report in this year is the topic 'agriculture as an energy producer'. In 44 contributions, the agrarian events of the year 2007 are analyzed and the setting the points for the future are discussed. The topics of this report are: Agricultural policy and social situation, world trade and nutrition, ecological agriculture, production and market, regional market, regional development, nature and environment, forest, animal protection and animal husbandry, genetic engineering, agrarian culture, consumer and nourishing culture.

The Relationship of Scaffolding on Cognitive Load in an Online Self-Regulated Learning Environment

Science.gov (United States)

Danilenko, Eugene Paul

2010-01-01

Scaffolding learners in self-regulated learning environments is a topic of increasing importance as implementation of online learning grows. Since cognitive overload in hypermedia environments can be a problem for some learners, instructional design strategies can be used to decrease extraneous load or encourage germane load in order to help…

Efficacy of topical cysteamine in nephropathic cystinosis.

Science.gov (United States)

Al-Hemidan, Amal; Shoughy, Samir S; Kozak, Igor; Tabbara, Khalid F

2017-09-01

The aim of this study is to evaluate the efficacy of topical cysteamine 0.55% eye drops in the treatment of corneal cystine crystal deposits in patients with nephropathic cystinosis. Thirty-two patients with nephropathic cystinosis were prospectively included in the study. Patients with corneal cystinosis were treated with topical cysteamine 0.55% eye drops. They were examined before treatment, on each monthly visit and after treatment at the last follow-up. Photophobia was classified as grade 0 (none) for no photophobia, grade 1 (mild) for photophobia in bright light, grade 2 (moderate) for photophobia in room light and grade 3 (severe) for photophobia in dim light. Corneal cystine crystals were graded as grade 0=none, grade 1=1-10 crystals/mm 2 , grade 2=11-50 crystals/mm 2 , grade 3=more than 50 crystals/mm 2 . The main outcome measure was evaluation of photophobia and resolution of corneal cystine crystals. There were 13 male and 19 female patients. The mean age was 8 years with an age range of 8 months to 19 years. The mean follow-up period was 4.1 years with a range of 2-8 years. Improvement of photophobia was not clinically significant in symptomatic patients. Patients displayed statistically significant worsening of corneal cystine deposits during the follow-up period. This study has shown that topical 0.55% cysteamine eye drops may have limited effects in decreasing the corneal cystine deposits in patients with severe forms of nephropathic cystinosis. NCT02766855, Results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Cost Utility Analysis of Topical Steroids Compared With Dietary Elimination for Treatment of Eosinophilic Esophagitis.

Science.gov (United States)

Cotton, Cary C; Erim, Daniel; Eluri, Swathi; Palmer, Sarah H; Green, Daniel J; Wolf, W Asher; Runge, Thomas M; Wheeler, Stephanie; Shaheen, Nicholas J; Dellon, Evan S

2017-06-01

Topical corticosteroids or dietary elimination are recommended as first-line therapies for eosinophilic esophagitis, but data to directly compare these therapies are scant. We performed a cost utility comparison of topical corticosteroids and the 6-food elimination diet (SFED) in treatment of eosinophilic esophagitis, from the payer perspective. We used a modified Markov model based on current clinical guidelines, in which transition between states depended on histologic response simulated at the individual cohort-member level. Simulation parameters were defined by systematic review and meta-analysis to determine the base-case estimates and bounds of uncertainty for sensitivity analysis. Meta-regression models included adjustment for differences in study and cohort characteristics. In the base-case scenario, topical fluticasone was about as effective as SFED but more expensive at a 5-year time horizon ($9261.58 vs $5719.72 per person). SFED was more effective and less expensive than topical fluticasone and topical budesonide in the base-case scenario. Probabilistic sensitivity analysis revealed little uncertainty in relative treatment effectiveness. There was somewhat greater uncertainty in the relative cost of treatments; most simulations found SFED to be less expensive. In a cost utility analysis comparing topical corticosteroids and SFED for first-line treatment of eosinophilic esophagitis, the therapies were similar in effectiveness. SFED was on average less expensive, and more cost effective in most simulations, than topical budesonide and topical fluticasone, from a payer perspective and not accounting for patient-level costs or quality of life. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

Directory of Open Access Journals (Sweden)

Deng-Fu Yang

2014-09-01

Conclusion: We conclude that topical MTX-pretreatment can increase intracellular PpIX production in hamster buccal pouch precancerous lesions and significantly improves the outcomes of the precancerous lesions treated with topical ALA-PDT.