WorldWideScience

Sample records for enters large-scale clinical

  1. Leverage hadoop framework for large scale clinical informatics applications.

    Science.gov (United States)

    Dong, Xiao; Bahroos, Neil; Sadhu, Eugene; Jackson, Tommie; Chukhman, Morris; Johnson, Robert; Boyd, Andrew; Hynes, Denise

    2013-01-01

    In this manuscript, we present our experiences using the Apache Hadoop framework for high data volume and computationally intensive applications, and discuss some best practice guidelines in a clinical informatics setting. There are three main aspects in our approach: (a) process and integrate diverse, heterogeneous data sources using standard Hadoop programming tools and customized MapReduce programs; (b) after fine-grained aggregate results are obtained, perform data analysis using the Mahout data mining library; (c) leverage the column oriented features in HBase for patient centric modeling and complex temporal reasoning. This framework provides a scalable solution to meet the rapidly increasing, imperative "Big Data" needs of clinical and translational research. The intrinsic advantage of fault tolerance, high availability and scalability of Hadoop platform makes these applications readily deployable at the enterprise level cluster environment.

  2. How Can the Evidence from Global Large-scale Clinical Trials for Cardiovascular Diseases be Improved?

    Science.gov (United States)

    Sawata, Hiroshi; Tsutani, Kiichiro

    2011-06-29

    Clinical investigations are important for obtaining evidence to improve medical treatment. Large-scale clinical trials with thousands of participants are particularly important for this purpose in cardiovascular diseases. Conducting large-scale clinical trials entails high research costs. This study sought to investigate global trends in large-scale clinical trials in cardiovascular diseases. We searched for trials using clinicaltrials.gov (URL: http://www.clinicaltrials.gov/) using the key words 'cardio' and 'event' in all fields on 10 April, 2010. We then selected trials with 300 or more participants examining cardiovascular diseases. The search revealed 344 trials that met our criteria. Of 344 trials, 71% were randomized controlled trials, 15% involved more than 10,000 participants, and 59% were funded by industry. In RCTs whose results were disclosed, 55% of industry-funded trials and 25% of non-industry funded trials reported statistically significant superiority over control (p = 0.012, 2-sided Fisher's exact test). Our findings highlighted concerns regarding potential bias related to funding sources, and that researchers should be aware of the importance of trial information disclosures and conflicts of interest. We should keep considering management and training regarding information disclosures and conflicts of interest for researchers. This could lead to better clinical evidence and further improvements in the development of medical treatment worldwide.

  3. How Can the Evidence from Global Large-scale Clinical Trials for Cardiovascular Diseases be Improved?

    Directory of Open Access Journals (Sweden)

    Tsutani Kiichiro

    2011-06-01

    Full Text Available Abstract Background Clinical investigations are important for obtaining evidence to improve medical treatment. Large-scale clinical trials with thousands of participants are particularly important for this purpose in cardiovascular diseases. Conducting large-scale clinical trials entails high research costs. This study sought to investigate global trends in large-scale clinical trials in cardiovascular diseases. Findings We searched for trials using clinicaltrials.gov (URL: http://www.clinicaltrials.gov/ using the key words 'cardio' and 'event' in all fields on 10 April, 2010. We then selected trials with 300 or more participants examining cardiovascular diseases. The search revealed 344 trials that met our criteria. Of 344 trials, 71% were randomized controlled trials, 15% involved more than 10,000 participants, and 59% were funded by industry. In RCTs whose results were disclosed, 55% of industry-funded trials and 25% of non-industry funded trials reported statistically significant superiority over control (p = 0.012, 2-sided Fisher's exact test. Conclusions Our findings highlighted concerns regarding potential bias related to funding sources, and that researchers should be aware of the importance of trial information disclosures and conflicts of interest. We should keep considering management and training regarding information disclosures and conflicts of interest for researchers. This could lead to better clinical evidence and further improvements in the development of medical treatment worldwide.

  4. Limited accessibility to designs and results of Japanese large-scale clinical trials for cardiovascular diseases.

    Science.gov (United States)

    Sawata, Hiroshi; Ueshima, Kenji; Tsutani, Kiichiro

    2011-04-14

    Clinical evidence is important for improving the treatment of patients by health care providers. In the study of cardiovascular diseases, large-scale clinical trials involving thousands of participants are required to evaluate the risks of cardiac events and/or death. The problems encountered in conducting the Japanese Acute Myocardial Infarction Prospective (JAMP) study highlighted the difficulties involved in obtaining the financial and infrastructural resources necessary for conducting large-scale clinical trials. The objectives of the current study were: 1) to clarify the current funding and infrastructural environment surrounding large-scale clinical trials in cardiovascular and metabolic diseases in Japan, and 2) to find ways to improve the environment surrounding clinical trials in Japan more generally. We examined clinical trials examining cardiovascular diseases that evaluated true endpoints and involved 300 or more participants using Pub-Med, Ichushi (by the Japan Medical Abstracts Society, a non-profit organization), websites of related medical societies, the University Hospital Medical Information Network (UMIN) Clinical Trials Registry, and clinicaltrials.gov at three points in time: 30 November, 2004, 25 February, 2007 and 25 July, 2009. We found a total of 152 trials that met our criteria for 'large-scale clinical trials' examining cardiovascular diseases in Japan. Of these, 72.4% were randomized controlled trials (RCTs). Of 152 trials, 9.2% of the trials examined more than 10,000 participants, and 42.8% examined between 1,000 and 10,000 participants. The number of large-scale clinical trials markedly increased from 2001 to 2004, but suddenly decreased in 2007, then began to increase again. Ischemic heart disease (39.5%) was the most common target disease. Most of the larger-scale trials were funded by private organizations such as pharmaceutical companies. The designs and results of 13 trials were not disclosed. To improve the quality of clinical

  5. Limited accessibility to designs and results of Japanese large-scale clinical trials for cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Tsutani Kiichiro

    2011-04-01

    Full Text Available Abstract Background Clinical evidence is important for improving the treatment of patients by health care providers. In the study of cardiovascular diseases, large-scale clinical trials involving thousands of participants are required to evaluate the risks of cardiac events and/or death. The problems encountered in conducting the Japanese Acute Myocardial Infarction Prospective (JAMP study highlighted the difficulties involved in obtaining the financial and infrastructural resources necessary for conducting large-scale clinical trials. The objectives of the current study were: 1 to clarify the current funding and infrastructural environment surrounding large-scale clinical trials in cardiovascular and metabolic diseases in Japan, and 2 to find ways to improve the environment surrounding clinical trials in Japan more generally. Methods We examined clinical trials examining cardiovascular diseases that evaluated true endpoints and involved 300 or more participants using Pub-Med, Ichushi (by the Japan Medical Abstracts Society, a non-profit organization, websites of related medical societies, the University Hospital Medical Information Network (UMIN Clinical Trials Registry, and clinicaltrials.gov at three points in time: 30 November, 2004, 25 February, 2007 and 25 July, 2009. Results We found a total of 152 trials that met our criteria for 'large-scale clinical trials' examining cardiovascular diseases in Japan. Of these, 72.4% were randomized controlled trials (RCTs. Of 152 trials, 9.2% of the trials examined more than 10,000 participants, and 42.8% examined between 1,000 and 10,000 participants. The number of large-scale clinical trials markedly increased from 2001 to 2004, but suddenly decreased in 2007, then began to increase again. Ischemic heart disease (39.5% was the most common target disease. Most of the larger-scale trials were funded by private organizations such as pharmaceutical companies. The designs and results of 13 trials were not

  6. Deciphering the clinical effect of drugs through large-scale data integration

    DEFF Research Database (Denmark)

    Kjærulff, Sonny Kim

    . This work demonstrates the power of a strategy that uses clinical data mining in association with chemical biology in order to reduce the search space and aid identification of novel drug actions. The second article described in chapter 3 outlines a high confidence side-effect-drug interaction dataset. We...... demonstrates the importance of using high-confidence drug-side-effect data in deciphering the effect of small molecules in humans. In summary, this thesis presents computational systems chemical biology approaches that can help identify clinical effects of small molecules through large-scale data integration...

  7. Perspectives on Clinical Informatics: Integrating Large-Scale Clinical, Genomic, and Health Information for Clinical Care

    Directory of Open Access Journals (Sweden)

    In Young Choi

    2013-12-01

    Full Text Available The advances in electronic medical records (EMRs and bioinformatics (BI represent two significant trends in healthcare. The widespread adoption of EMR systems and the completion of the Human Genome Project developed the technologies for data acquisition, analysis, and visualization in two different domains. The massive amount of data from both clinical and biology domains is expected to provide personalized, preventive, and predictive healthcare services in the near future. The integrated use of EMR and BI data needs to consider four key informatics areas: data modeling, analytics, standardization, and privacy. Bioclinical data warehouses integrating heterogeneous patient-related clinical or omics data should be considered. The representative standardization effort by the Clinical Bioinformatics Ontology (CBO aims to provide uniquely identified concepts to include molecular pathology terminologies. Since individual genome data are easily used to predict current and future health status, different safeguards to ensure confidentiality should be considered. In this paper, we focused on the informatics aspects of integrating the EMR community and BI community by identifying opportunities, challenges, and approaches to provide the best possible care service for our patients and the population.

  8. Large-scale adenovirus and poxvirus-vectored vaccine manufacturing to enable clinical trials.

    Science.gov (United States)

    Kallel, Héla; Kamen, Amine A

    2015-05-01

    Efforts to make vaccines against infectious diseases and immunotherapies for cancer have evolved to utilize a variety of heterologous expression systems such as viral vectors. These vectors are often attenuated or engineered to safely deliver genes encoding antigens of different pathogens. Adenovirus and poxvirus vectors are among the viral vectors that are most frequently used to develop prophylactic vaccines against infectious diseases as well as therapeutic cancer vaccines. This mini-review describes the trends and processes in large-scale production of adenovirus and poxvirus vectors to meet the needs of clinical applications. We briefly describe the general principles for the production and purification of adenovirus and poxvirus viral vectors. Currently, adenovirus and poxvirus vector manufacturing methods rely on well-established cell culture technologies. Several improvements have been evaluated to increase the yield and to reduce the overall manufacturing cost, such as cultivation at high cell densities and continuous downstream processing. Additionally, advancements in vector characterization will greatly facilitate the development of novel vectored vaccine candidates. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Large scale implementation of clinical medication reviews in Dutch community pharmacies: Drug-related problems and interventions

    NARCIS (Netherlands)

    Kempen, Thomas G. H.; Van De Steeg-Van Gompel, Caroline H. P. A.; Hoogland, Petra; Liu, Yuqian; Bouvy, Marcel L.

    2014-01-01

    Background: Research on the benefits of clinical medication reviews (CMRs) performed by pharmacists has been conducted mostly in controlled settings and has been widely published. Less is known of the effects after large scale implementation in community pharmacies. An online CMR tool enabled the

  10. WHY DO WE STILL NEED LARGE SCALE CLINICAL TRIAL: THE CASE OF N-3 PUFA

    Directory of Open Access Journals (Sweden)

    Roberto eMarchioli

    2012-06-01

    Full Text Available After the first reports about a protective effect on coronary heart disease (CHD published more than 40 years ago, wide interest in the therapeutic use of n-3 polyunsaturated fatty acids (n-3 PUFA aroused. Since then, many studies and meta-analyses have reported a significantly reduced risk of CHD and CV death due to fish and n-3 PUFA intake. Some of the overviews reported a significant reduction of risk of sudden cardiac death (SCD, all-cause death, and nonfatal CV events. On the other side, recent clinical trials had mixed findings, raising concern about the consistency of the evidence on n-3 PUFA. We critically reviewed recent large clinical trials reporting data on the antiarrhythmic effects of n-3 PUFA in different clinical settings, i.e. patients with CHD, heart failure, with implantable cardioverter defibrillator (ICD, and at risk of atrial fibrillation, in order to summarize the results which are available up to date and possibly give substantiated fuel to the debate on the conflicting results of n-3 PUFA.

  11. Large-scale clinical comparison of the lysis-centrifugation and radiometric systems for blood culture

    International Nuclear Information System (INIS)

    Brannon, P.; Kiehn, T.E.

    1985-01-01

    The Isolator 10 lysis-centrifugation blood culture system (E. I. du Pont de Nemours and Co., Inc., Wilmington, Del.) was compared with the BACTEC radiometric method (Johnston Laboratories, Inc., Towson, Md.) with 6B and 7D broth media for the recovery of bacteria and yeasts. From 11,000 blood cultures, 1,174 clinically significant organisms were isolated. The Isolator system recovered significantly more total organisms, members of the family Enterobacteriaceae, Staphylococcus spp., and yeasts. The BACTEC system recovered significantly more Pseudomonas spp., Streptococcus spp., and anaerobes. Of the Isolator colony counts, 87% measured less than 11 CFU/ml of blood. Organisms, on an average, were detected the same day from each of the two culture systems. Only 13 of the 975 BACTEC isolates (0.01%) were recovered by subculture of growth-index-negative bottles, and 12 of the 13 were detected in another broth blood culture taken within 24 h. Contaminants were recovered from 4.8% of the Isolator 10 and 2.3% of the BACTEC cultures

  12. Clinical and nutritional implications of radiation enteritis

    International Nuclear Information System (INIS)

    Beer, W.H.; Fan, A.; Halsted, C.H.

    1985-01-01

    The clinical and nutritional significance of radiation enteritis was assessed in eight patients with chronic diarrhea which followed curative doses of radiotherapy for pelvic malignancies. Steatorrhea, found in seven malnourished patients, was ascribed to ileal disease or previous surgery, or to bacterial contamination of the small intestine. Lactose intolerance, assessed by breath hydrogen excretion after oral lactose and by jejunal lactase levels, was found in six patients. In a subgroup of five patients, the administration of two different defined formula liquid diets by nasoduodenal infusion decreased fecal fluid and energy losses by about one-half. Compared to Vivonex-HN, the infusion of Criticare-HN was associated with greater likelihood of intestinal gas production but a three-fold greater utilization of protein. Intestinal malabsorption and malnutrition in radiation enteritis has diverse etiologies. Whereas nutritional support by liquid diet limits fecal fluid and energy losses, these diets differ significantly in clinical tolerance and biologic value

  13. Clinical and nutritional implications of radiation enteritis

    Energy Technology Data Exchange (ETDEWEB)

    Beer, W.H.; Fan, A.; Halsted, C.H.

    1985-01-01

    The clinical and nutritional significance of radiation enteritis was assessed in eight patients with chronic diarrhea which followed curative doses of radiotherapy for pelvic malignancies. Steatorrhea, found in seven malnourished patients, was ascribed to ileal disease or previous surgery, or to bacterial contamination of the small intestine. Lactose intolerance, assessed by breath hydrogen excretion after oral lactose and by jejunal lactase levels, was found in six patients. In a subgroup of five patients, the administration of two different defined formula liquid diets by nasoduodenal infusion decreased fecal fluid and energy losses by about one-half. Compared to Vivonex-HN, the infusion of Criticare-HN was associated with greater likelihood of intestinal gas production but a three-fold greater utilization of protein. Intestinal malabsorption and malnutrition in radiation enteritis has diverse etiologies. Whereas nutritional support by liquid diet limits fecal fluid and energy losses, these diets differ significantly in clinical tolerance and biologic value.

  14. Large-scale manufacture and characterization of a lentiviral vector produced for clinical ex vivo gene therapy application.

    Science.gov (United States)

    Merten, Otto-Wilhelm; Charrier, Sabine; Laroudie, Nicolas; Fauchille, Sylvain; Dugué, Céline; Jenny, Christine; Audit, Muriel; Zanta-Boussif, Maria-Antonietta; Chautard, Hélène; Radrizzani, Marina; Vallanti, Giuliana; Naldini, Luigi; Noguiez-Hellin, Patricia; Galy, Anne

    2011-03-01

    From the perspective of a pilot clinical gene therapy trial for Wiskott-Aldrich syndrome (WAS), we implemented a process to produce a lentiviral vector under good manufacturing practices (GMP). The process is based on the transient transfection of 293T cells in Cell Factory stacks, scaled up to harvest 50 liters of viral stock per batch, followed by purification of the vesicular stomatitis virus glycoprotein-pseudotyped particles through several membrane-based and chromatographic steps. The process leads to a 200-fold volume concentration and an approximately 3-log reduction in protein and DNA contaminants. An average yield of 13% of infectious particles was obtained in six full-scale preparations. The final product contained low levels of contaminants such as simian virus 40 large T antigen or E1A sequences originating from producer cells. Titers as high as 2 × 10(9) infectious particles per milliliter were obtained, generating up to 6 × 10(11) infectious particles per batch. The purified WAS vector was biologically active, efficiently expressing the genetic insert in WAS protein-deficient B cell lines and transducing CD34(+) cells. The vector introduced 0.3-1 vector copy per cell on average in CD34(+) cells when used at the concentration of 10(8) infectious particles per milliliter, which is comparable to preclinical preparations. There was no evidence of cellular toxicity. These results show the implementation of large-scale GMP production, purification, and control of advanced HIV-1-derived lentiviral technology. Results obtained with the WAS vector provide the initial manufacturing and quality control benchmarking that should be helpful to further development and clinical applications.

  15. Large scale electrolysers

    International Nuclear Information System (INIS)

    B Bello; M Junker

    2006-01-01

    Hydrogen production by water electrolysis represents nearly 4 % of the world hydrogen production. Future development of hydrogen vehicles will require large quantities of hydrogen. Installation of large scale hydrogen production plants will be needed. In this context, development of low cost large scale electrolysers that could use 'clean power' seems necessary. ALPHEA HYDROGEN, an European network and center of expertise on hydrogen and fuel cells, has performed for its members a study in 2005 to evaluate the potential of large scale electrolysers to produce hydrogen in the future. The different electrolysis technologies were compared. Then, a state of art of the electrolysis modules currently available was made. A review of the large scale electrolysis plants that have been installed in the world was also realized. The main projects related to large scale electrolysis were also listed. Economy of large scale electrolysers has been discussed. The influence of energy prices on the hydrogen production cost by large scale electrolysis was evaluated. (authors)

  16. Large scale reflood test

    International Nuclear Information System (INIS)

    Hirano, Kemmei; Murao, Yoshio

    1980-01-01

    The large-scale reflood test with a view to ensuring the safety of light water reactors was started in fiscal 1976 based on the special account act for power source development promotion measures by the entrustment from the Science and Technology Agency. Thereafter, to establish the safety of PWRs in loss-of-coolant accidents by joint international efforts, the Japan-West Germany-U.S. research cooperation program was started in April, 1980. Thereupon, the large-scale reflood test is now included in this program. It consists of two tests using a cylindrical core testing apparatus for examining the overall system effect and a plate core testing apparatus for testing individual effects. Each apparatus is composed of the mock-ups of pressure vessel, primary loop, containment vessel and ECCS. The testing method, the test results and the research cooperation program are described. (J.P.N.)

  17. Overcoming the bottleneck of platelet lysate supply in large-scale clinical expansion of adipose-derived stem cells

    DEFF Research Database (Denmark)

    Glovinski, Peter Viktor; Herly, Mikkel; Mathiasen, Anders B

    2017-01-01

    , we tested PLs prepared via three methods from outdated buffy coat-derived platelet concentrates (PCs) to establish an efficient and feasible expansion of ASCs for clinical use. METHODS: PLs were prepared by the freeze-thaw method from freshly drawn platelets or from outdated buffy coat-derived PCs...

  18. Adolescent Linkage to Care After a Large-scale Transfer From a Hospital-based HIV Clinic to the Public Sector in South Africa.

    Science.gov (United States)

    Ramirez-Avila, Lynn; Regan, Susan; Cloete, Christie; Crankshaw, Tamaryn; Rabideau, Dustin J; Freedberg, Kenneth A; Parker, Robert A; Walensky, Rochelle P; Losina, Elena; Bassett, Ingrid V

    2017-03-01

    HIV clinics formerly supported by the President's Emergency Plan for AIDS Relief are transferring patients to public-sector clinics. We evaluated adolescent linkage to care after a large-scale transfer from a President's Emergency Plan for AIDS Relief-subsidized pediatric HIV clinic in Durban, South Africa. All adolescents (11-18 years) in care at a pediatric state-subsidized, hospital-based clinic (HBC) were transferred, from May to June 2012, to government sites [primary health care (PHC) clinic; community health center (CHC); and HBCs] or private clinics. Caregivers were surveyed 7-8 months after transfer to assess their adolescents' linkage to care and their reports were validated by clinic record audits in a subset of randomly selected clinics. Of the 309 (91%) caregivers reached, only 5 (2%) reported that their adolescent did not link. Of the 304 adolescents who linked, 105 (35%) were referred to a PHC, 73 (24%) to a CHC and 106 (35%) to a HBC. A total of 146 (48%) linked adolescents attended a different clinic than that assigned. Thirty-five (20%) of the 178 who linked and were assigned to a PHC or CHC ultimately attended a HBC. Based on clinic validation, the estimated transfer success was 88% (95% confidence interval: 77%-97%). The large majority of adolescents successfully transferred to a new HIV clinic, although nearly half attended a clinic other than that assigned.

  19. Factors associated with compliance and non-compliance by physicians in a large-scale randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Rahman Mahbubur

    2006-08-01

    Full Text Available Abstract Background In order to minimize the amount of incomplete follow-up data, reducing the non-compliance of participating physicians is one of the key issues for the data coordinating center in a multi-center trial. Identifying the physicians' non-compliance in advance is considered to be an important strategy for more efficient conduct of trials. In this study, we identified physicians' characteristics and factors associated with the need for individual visits to institutions to collect data or to complete information during two years of follow-up in a large Japanese investigator-initiated trial related to cardiovascular disease. Methods We categorized the physicians into two groups, "complier" and "non-complier". Odds ratios and corresponding 95% confidence intervals were calculated for 11 factors related to the characteristics of and compliance by physicians. Multiple logistic regression analysis was also performed. In addition, we evaluated the incremental cost for obtaining additional information of the non-compliant physicians. Results Three factors were identified in multiple logistic regression analysis as being significantly associated with compliance status: 1 prior participation in clinical trials (OR = 0.40 95%CI = 0.21–0.74; 2 physician opinion that the support system for case registration and follow-up was well organized (OR = 0.41 95%CI = 0.22–0.75; and 3 number of patients recruited (OR = 2.25 95%CI = 1.01–5.02. The actual incremental cost was about US $112,000 (14.4% of total routine follow-up costs for the non-compliant physicians during the 2 years, or about US $570 per patient. Conclusion Investigator-initiated clinical trials have recently attracted great interest, but they often suffer from insufficient funding. If trial networks are to be well organized, it is important that trials are conducted more efficiently. We believe that our findings will be useful for reducing the additional burden associated with

  20. Regional enteritis and gluten-free diet. A clinical study

    NARCIS (Netherlands)

    Merwe, Christiaan Frederik van der

    1974-01-01

    The purpose of this clinical study was to determine whether the use of a gluten-free diet influenced the course and prognosis of regional enteritis. Following a few clinical communications in the Dutch medical literature reporting favourable results obtained with the gluten-free diet in the

  1. Large Scale Solar Heating

    DEFF Research Database (Denmark)

    Heller, Alfred

    2001-01-01

    The main objective of the research was to evaluate large-scale solar heating connected to district heating (CSDHP), to build up a simulation tool and to demonstrate the application of the simulation tool for design studies and on a local energy planning case. The evaluation was mainly carried out...... model is designed and validated on the Marstal case. Applying the Danish Reference Year, a design tool is presented. The simulation tool is used for proposals for application of alternative designs, including high-performance solar collector types (trough solar collectors, vaccum pipe collectors......). Simulation programs are proposed as control supporting tool for daily operation and performance prediction of central solar heating plants. Finaly the CSHP technolgy is put into persepctive with respect to alternatives and a short discussion on the barries and breakthrough of the technology are given....

  2. Large scale model testing

    International Nuclear Information System (INIS)

    Brumovsky, M.; Filip, R.; Polachova, H.; Stepanek, S.

    1989-01-01

    Fracture mechanics and fatigue calculations for WWER reactor pressure vessels were checked by large scale model testing performed using large testing machine ZZ 8000 (with a maximum load of 80 MN) at the SKODA WORKS. The results are described from testing the material resistance to fracture (non-ductile). The testing included the base materials and welded joints. The rated specimen thickness was 150 mm with defects of a depth between 15 and 100 mm. The results are also presented of nozzles of 850 mm inner diameter in a scale of 1:3; static, cyclic, and dynamic tests were performed without and with surface defects (15, 30 and 45 mm deep). During cyclic tests the crack growth rate in the elastic-plastic region was also determined. (author). 6 figs., 2 tabs., 5 refs

  3. Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate.

    Science.gov (United States)

    Haack-Sørensen, Mandana; Juhl, Morten; Follin, Bjarke; Harary Søndergaard, Rebekka; Kirchhoff, Maria; Kastrup, Jens; Ekblond, Annette

    2018-04-17

    In vitro expanded adipose-derived stromal cells (ASCs) are a useful resource for tissue regeneration. Translation of small-scale autologous cell production into a large-scale, allogeneic production process for clinical applications necessitates well-chosen raw materials and cell culture platform. We compare the use of clinical-grade human platelet lysate (hPL) and fetal bovine serum (FBS) as growth supplements for ASC expansion in the automated, closed hollow fibre quantum cell expansion system (bioreactor). Stromal vascular fractions were isolated from human subcutaneous abdominal fat. In average, 95 × 10 6 cells were suspended in 10% FBS or 5% hPL medium, and loaded into a bioreactor coated with cryoprecipitate. ASCs (P0) were harvested, and 30 × 10 6 ASCs were reloaded for continued expansion (P1). Feeding rate and time of harvest was guided by metabolic monitoring. Viability, sterility, purity, differentiation capacity, and genomic stability of ASCs P1 were determined. Cultivation of SVF in hPL medium for in average nine days, yielded 546 × 10 6 ASCs compared to 111 × 10 6 ASCs, after 17 days in FBS medium. ASCs P1 yields were in average 605 × 10 6 ASCs (PD [population doublings]: 4.65) after six days in hPL medium, compared to 119 × 10 6 ASCs (PD: 2.45) in FBS medium, after 21 days. ASCs fulfilled ISCT criteria and demonstrated genomic stability and sterility. The use of hPL as a growth supplement for ASCs expansion in the quantum cell expansion system provides an efficient expansion process compared to the use of FBS, while maintaining cell quality appropriate for clinical use. The described process is an obvious choice for manufacturing of large-scale allogeneic ASC products.

  4. Large scale tracking algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Ross L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Love, Joshua Alan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Melgaard, David Kennett [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Karelitz, David B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pitts, Todd Alan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Zollweg, Joshua David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Anderson, Dylan Z. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nandy, Prabal [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Whitlow, Gary L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bender, Daniel A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Byrne, Raymond Harry [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-01-01

    Low signal-to-noise data processing algorithms for improved detection, tracking, discrimination and situational threat assessment are a key research challenge. As sensor technologies progress, the number of pixels will increase signi cantly. This will result in increased resolution, which could improve object discrimination, but unfortunately, will also result in a significant increase in the number of potential targets to track. Many tracking techniques, like multi-hypothesis trackers, suffer from a combinatorial explosion as the number of potential targets increase. As the resolution increases, the phenomenology applied towards detection algorithms also changes. For low resolution sensors, "blob" tracking is the norm. For higher resolution data, additional information may be employed in the detection and classfication steps. The most challenging scenarios are those where the targets cannot be fully resolved, yet must be tracked and distinguished for neighboring closely spaced objects. Tracking vehicles in an urban environment is an example of such a challenging scenario. This report evaluates several potential tracking algorithms for large-scale tracking in an urban environment.

  5. Large-scale STI services in Avahan improve utilization and treatment seeking behaviour amongst high-risk groups in India: an analysis of clinical records from six states

    Directory of Open Access Journals (Sweden)

    Gurung Anup

    2011-12-01

    Full Text Available Abstract Background Avahan, the India AIDS Initiative, implemented a large HIV prevention programme across six high HIV prevalence states amongst high risk groups consisting of female sex workers, high risk men who have sex with men, transgenders and injecting drug users in India. Utilization of the clinical services, health seeking behaviour and trends in syndromic diagnosis of sexually transmitted infections amongst these populations were measured using the individual tracking data. Methods The Avahan clinical monitoring system included individual tracking data pertaining to clinical services amongst high risk groups. All clinic visits were recorded in the routine clinical monitoring system using unique identification numbers at the NGO-level. Visits by individual clinic attendees were tracked from January 2005 to December 2009. An analysis examining the limited variables over time, stratified by risk group, was performed. Results A total of 431,434 individuals including 331,533 female sex workers, 10,280 injecting drug users, 82,293 men who have sex with men, and 7,328 transgenders visited the clinics with a total of 2,700,192 visits. Individuals made an average of 6.2 visits to the clinics during the study period. The number of visits per person increased annually from 1.2 in 2005 to 8.3 in 2009. The proportion of attendees visiting clinics more than four times a year increased from 4% in 2005 to 26% in 2009 (p Conclusions The programme demonstrated that acceptable and accessible services with marginalised and often difficult–to-reach populations can be brought to a very large scale using standardized approaches. Utilization of these services can dramatically improve health seeking behaviour and reduce STI prevalence.

  6. Using large-scale Granger causality to study changes in brain network properties in the Clinically Isolated Syndrome (CIS) stage of multiple sclerosis

    Science.gov (United States)

    Abidin, Anas Z.; Chockanathan, Udaysankar; DSouza, Adora M.; Inglese, Matilde; Wismüller, Axel

    2017-03-01

    Clinically Isolated Syndrome (CIS) is often considered to be the first neurological episode associated with Multiple sclerosis (MS). At an early stage the inflammatory demyelination occurring in the CNS can manifest as a change in neuronal metabolism, with multiple asymptomatic white matter lesions detected in clinical MRI. Such damage may induce topological changes of brain networks, which can be captured by advanced functional MRI (fMRI) analysis techniques. We test this hypothesis by capturing the effective relationships of 90 brain regions, defined in the Automated Anatomic Labeling (AAL) atlas, using a large-scale Granger Causality (lsGC) framework. The resulting networks are then characterized using graph-theoretic measures that quantify various network topology properties at a global as well as at a local level. We study for differences in these properties in network graphs obtained for 18 subjects (10 male and 8 female, 9 with CIS and 9 healthy controls). Global network properties captured trending differences with modularity and clustering coefficient (pdifferences in some regions of the inferior frontal and parietal lobe. We conclude that multivariate analysis of fMRI time-series can reveal interesting information about changes occurring in the brain in early stages of MS.

  7. Characterizing stroke lesions using digital templates and lesion quantification tools in a web-based imaging informatics system for a large-scale stroke rehabilitation clinical trial

    Science.gov (United States)

    Wang, Ximing; Edwardson, Matthew; Dromerick, Alexander; Winstein, Carolee; Wang, Jing; Liu, Brent

    2015-03-01

    Previously, we presented an Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE) imaging informatics system that supports a large-scale phase III stroke rehabilitation trial. The ePR system is capable of displaying anonymized patient imaging studies and reports, and the system is accessible to multiple clinical trial sites and users across the United States via the web. However, the prior multicenter stroke rehabilitation trials lack any significant neuroimaging analysis infrastructure. In stroke related clinical trials, identification of the stroke lesion characteristics can be meaningful as recent research shows that lesion characteristics are related to stroke scale and functional recovery after stroke. To facilitate the stroke clinical trials, we hope to gain insight into specific lesion characteristics, such as vascular territory, for patients enrolled into large stroke rehabilitation trials. To enhance the system's capability for data analysis and data reporting, we have integrated new features with the system: a digital brain template display, a lesion quantification tool and a digital case report form. The digital brain templates are compiled from published vascular territory templates at each of 5 angles of incidence. These templates were updated to include territories in the brainstem using a vascular territory atlas and the Medical Image Processing, Analysis and Visualization (MIPAV) tool. The digital templates are displayed for side-by-side comparisons and transparent template overlay onto patients' images in the image viewer. The lesion quantification tool quantifies planimetric lesion area from user-defined contour. The digital case report form stores user input into a database, then displays contents in the interface to allow for reviewing, editing, and new inputs. In sum, the newly integrated system features provide the user with readily-accessible web-based tools to identify the vascular territory involved, estimate lesion area

  8. Large-Scale Evaluation of Quality of Care in 6 Countries of Eastern Europe and Central Asia Using Clinical Performance and Value Vignettes.

    Science.gov (United States)

    Peabody, John W; DeMaria, Lisa; Smith, Owen; Hoth, Angela; Dragoti, Edmond; Luck, Jeff

    2017-09-27

    challenged by poor performance as measured by clinical care vignettes, but there is potential for provision of high-quality care by a sizable proportion of providers. Large-scale assessments of quality of care have been hampered by the lack of effective measurement tools that provide generalizable and reliable results across diverse economic, cultural, and social settings. The feasibility of quality measurement using CPV vignettes in these 6 countries and the ability to combine results with individual feedback could significantly enhance strategies to improve quality of care, and ultimately population health. © Peabody et al.

  9. Large-scale solar purchasing

    International Nuclear Information System (INIS)

    1999-01-01

    The principal objective of the project was to participate in the definition of a new IEA task concerning solar procurement (''the Task'') and to assess whether involvement in the task would be in the interest of the UK active solar heating industry. The project also aimed to assess the importance of large scale solar purchasing to UK active solar heating market development and to evaluate the level of interest in large scale solar purchasing amongst potential large scale purchasers (in particular housing associations and housing developers). A further aim of the project was to consider means of stimulating large scale active solar heating purchasing activity within the UK. (author)

  10. Large-scale data analytics

    CERN Document Server

    Gkoulalas-Divanis, Aris

    2014-01-01

    Provides cutting-edge research in large-scale data analytics from diverse scientific areas Surveys varied subject areas and reports on individual results of research in the field Shares many tips and insights into large-scale data analytics from authors and editors with long-term experience and specialization in the field

  11. Lupus enteritis: from clinical findings to therapeutic management

    Science.gov (United States)

    2013-01-01

    Lupus enteritis is a rare and poorly understood cause of abdominal pain in patients with systemic lupus erythematosus (SLE). In this study, we report a series of 7 new patients with this rare condition who were referred to French tertiary care centers and perform a systematic literature review of SLE cases fulfilling the revised ACR criteria, with evidence for small bowel involvement, excluding those with infectious enteritis. We describe the characteristics of 143 previously published and 7 new cases. Clinical symptoms mostly included abdominal pain (97%), vomiting (42%), diarrhea (32%) and fever (20%). Laboratory features mostly reflected lupus activity: low complement levels (88%), anemia (52%), leukocytopenia or lymphocytopenia (40%) and thrombocytopenia (21%). Median CRP level was 2.0 mg/dL (range 0–8.2 mg/dL). Proteinuria was present in 47% of cases. Imaging studies revealed bowel wall edema (95%), ascites (78%), the characteristic target sign (71%), mesenteric abnormalities (71%) and bowel dilatation (24%). Only 9 patients (6%) had histologically confirmed vasculitis. All patients received corticosteroids as a first-line therapy, with additional immunosuppressants administered either from the initial episode or only in case of relapse (recurrence rate: 25%). Seven percent developed intestinal necrosis or perforation, yielding a mortality rate of 2.7%. Altogether, lupus enteritis is a poorly known cause of abdominal pain in SLE patients, with distinct clinical and therapeutic features. The disease may evolve to intestinal necrosis and perforation if untreated. Adding with this an excellent steroid responsiveness, timely diagnosis becomes primordial for the adequate management of this rare entity. PMID:23642042

  12. Large-scale grid management

    International Nuclear Information System (INIS)

    Langdal, Bjoern Inge; Eggen, Arnt Ove

    2003-01-01

    The network companies in the Norwegian electricity industry now have to establish a large-scale network management, a concept essentially characterized by (1) broader focus (Broad Band, Multi Utility,...) and (2) bigger units with large networks and more customers. Research done by SINTEF Energy Research shows so far that the approaches within large-scale network management may be structured according to three main challenges: centralization, decentralization and out sourcing. The article is part of a planned series

  13. Large scale structure and baryogenesis

    International Nuclear Information System (INIS)

    Kirilova, D.P.; Chizhov, M.V.

    2001-08-01

    We discuss a possible connection between the large scale structure formation and the baryogenesis in the universe. An update review of the observational indications for the presence of a very large scale 120h -1 Mpc in the distribution of the visible matter of the universe is provided. The possibility to generate a periodic distribution with the characteristic scale 120h -1 Mpc through a mechanism producing quasi-periodic baryon density perturbations during inflationary stage, is discussed. The evolution of the baryon charge density distribution is explored in the framework of a low temperature boson condensate baryogenesis scenario. Both the observed very large scale of a the visible matter distribution in the universe and the observed baryon asymmetry value could naturally appear as a result of the evolution of a complex scalar field condensate, formed at the inflationary stage. Moreover, for some model's parameters a natural separation of matter superclusters from antimatter ones can be achieved. (author)

  14. Enteric duplication in children: clinical presentation and outcome.

    Science.gov (United States)

    Rasool, Naima; Safdar, Chaudhry Aqeel; Ahmad, Asrar; Kanwal, Shehla

    2013-06-01

    Enteric duplication (ED) is an anomaly with varied presentations and possible involvement of the alimentary tract. Once diagnosed, resection of the lesion and the involved part of the gut is usually required. The aim of this study was to evaluate the clinical presentations, diagnostic investigations, management and outcomes of patients with ED. This was a descriptive case study conducted at the Department of Paediatric Surgery, Military Hospital, Rawalpindi, Pakistan, from January 2005 to January 2011. The medical records of all patients diagnosed with ED were retrospectively analysed with respect to age, presentation, investigations, site and type of lesion, surgical procedures, histological findings and complications. A total of nine patients were managed during the study period. The patients' ages ranged from three months to five years. Four out of nine EDs were rectal duplications. Three EDs were of the cystic type, five were of the tubular type and one was a complex mixed anomaly. Patients presented with varied symptoms, with the two most common being the presence of an abdominal mass and bleeding per rectum. Diagnosis was mainly achieved based on magnetic resonance imaging and computed tomography, although Meckel's scan provided accurate diagnosis in three of the nine patients. All the cysts were resected without any major complications, and patients were event-free during the five-year follow-up. EDs should be kept in mind when examining patients with an abdominal mass and bleeding per rectum. Meckel's scan can provide accurate diagnosis of EDs with bleeding. Prompt diagnosis and management results in satisfactory outcomes.

  15. Large-scale solar heat

    Energy Technology Data Exchange (ETDEWEB)

    Tolonen, J.; Konttinen, P.; Lund, P. [Helsinki Univ. of Technology, Otaniemi (Finland). Dept. of Engineering Physics and Mathematics

    1998-12-31

    In this project a large domestic solar heating system was built and a solar district heating system was modelled and simulated. Objectives were to improve the performance and reduce costs of a large-scale solar heating system. As a result of the project the benefit/cost ratio can be increased by 40 % through dimensioning and optimising the system at the designing stage. (orig.)

  16. Japanese large-scale interferometers

    CERN Document Server

    Kuroda, K; Miyoki, S; Ishizuka, H; Taylor, C T; Yamamoto, K; Miyakawa, O; Fujimoto, M K; Kawamura, S; Takahashi, R; Yamazaki, T; Arai, K; Tatsumi, D; Ueda, A; Fukushima, M; Sato, S; Shintomi, T; Yamamoto, A; Suzuki, T; Saitô, Y; Haruyama, T; Sato, N; Higashi, Y; Uchiyama, T; Tomaru, T; Tsubono, K; Ando, M; Takamori, A; Numata, K; Ueda, K I; Yoneda, H; Nakagawa, K; Musha, M; Mio, N; Moriwaki, S; Somiya, K; Araya, A; Kanda, N; Telada, S; Sasaki, M; Tagoshi, H; Nakamura, T; Tanaka, T; Ohara, K

    2002-01-01

    The objective of the TAMA 300 interferometer was to develop advanced technologies for kilometre scale interferometers and to observe gravitational wave events in nearby galaxies. It was designed as a power-recycled Fabry-Perot-Michelson interferometer and was intended as a step towards a final interferometer in Japan. The present successful status of TAMA is presented. TAMA forms a basis for LCGT (large-scale cryogenic gravitational wave telescope), a 3 km scale cryogenic interferometer to be built in the Kamioka mine in Japan, implementing cryogenic mirror techniques. The plan of LCGT is schematically described along with its associated R and D.

  17. Evaluation of the clinical implementation of a large-scale online e-learning program on venous blood specimen collection guideline practices.

    Science.gov (United States)

    Willman, Britta; Grankvist, Kjell; Bölenius, Karin

    2018-05-11

    When performed erroneously, the venous blood specimen collection (VBSC) practice steps patient identification, test request management and test tube labeling are at high risk to jeopardize patient safety. VBSC educational programs with the intention to minimize risk of harm to patients are therefore needed. In this study, we evaluate the efficiency of a large-scale online e-learning program on personnel's adherence to VBSC practices and their experience of the e-learning program. An interprofessional team transformed an implemented traditional VBSC education program to an online e-learning program developed to stimulate reflection with focus on the high-risk practice steps. We used questionnaires to evaluate the effect of the e-learning program on personnel's self-reported adherence to VBSC practices compared to questionnaire surveys before and after introduction of the traditional education program. We used content analysis to evaluate the participants free text experience of the VBSC e-learning program. Adherence to the VBSC guideline high-risk practice steps generally increased following the implementation of a traditional educational program followed by an e-learning program. We however found a negative trend over years regarding participation rates and the practice to always send/sign the request form following the introduction of an electronic request system. The participants were in general content with the VBSC e-learning program. Properly designed e-learning programs on VBSC practices supersedes traditional educational programs in usefulness and functionality. Inclusion of questionnaires in the e-learning program is necessary for follow-up of VBSC participant's practices and educational program efficiency.

  18. Testing Einstein's Gravity on Large Scales

    Science.gov (United States)

    Prescod-Weinstein, Chandra

    2011-01-01

    A little over a decade has passed since two teams studying high redshift Type Ia supernovae announced the discovery that the expansion of the universe was accelerating. After all this time, we?re still not sure how cosmic acceleration fits into the theory that tells us about the large-scale universe: General Relativity (GR). As part of our search for answers, we have been forced to question GR itself. But how will we test our ideas? We are fortunate enough to be entering the era of precision cosmology, where the standard model of gravity can be subjected to more rigorous testing. Various techniques will be employed over the next decade or two in the effort to better understand cosmic acceleration and the theory behind it. In this talk, I will describe cosmic acceleration, current proposals to explain it, and weak gravitational lensing, an observational effect that allows us to do the necessary precision cosmology.

  19. The natural history of clinically established radiation enteritis

    International Nuclear Information System (INIS)

    Galland, R.B.; Spencer, J.

    1985-01-01

    70 patients presenting to a surgical unit with radiation enteritis were followed up. 11 of the 61 who underwent operations died of operation-related causes. The 51 patients who survived for more than 3 months were followed up for up to 12 years (median 12 months). 24 had no further symptoms related to their radiation enteritis. The other 27 patients had persistence of symptoms, post-operative complications, new radiation-related problems, or a combination of these. The twenty new radiation-related problems were stricture (8 patients), malabsorption (5), fistula(1), and miscellaneous(6). These developed in in 12 of 36 patients presenting initially with stricture, compared with 8 of 9 patients presenting with a perforation or fistula (p=0.007 Fisher's exact test) and none whose first symptom was bleeding (p=0.001 vs perforation and fistula combined). 10 of the 27 patients with further problems required operations and 5 of them died. Radiation enteritis is thus a progressive disease, with further complications becoming apparent in about half of those surviving the initial lesion. Perforation or fistula formation indicates a poorer prognosis than does stricture or haemorrhage. (author)

  20. Large scale biomimetic membrane arrays

    DEFF Research Database (Denmark)

    Hansen, Jesper Søndergaard; Perry, Mark; Vogel, Jörg

    2009-01-01

    To establish planar biomimetic membranes across large scale partition aperture arrays, we created a disposable single-use horizontal chamber design that supports combined optical-electrical measurements. Functional lipid bilayers could easily and efficiently be established across CO2 laser micro......-structured 8 x 8 aperture partition arrays with average aperture diameters of 301 +/- 5 mu m. We addressed the electro-physical properties of the lipid bilayers established across the micro-structured scaffold arrays by controllable reconstitution of biotechnological and physiological relevant membrane...... peptides and proteins. Next, we tested the scalability of the biomimetic membrane design by establishing lipid bilayers in rectangular 24 x 24 and hexagonal 24 x 27 aperture arrays, respectively. The results presented show that the design is suitable for further developments of sensitive biosensor assays...

  1. Conference on Large Scale Optimization

    CERN Document Server

    Hearn, D; Pardalos, P

    1994-01-01

    On February 15-17, 1993, a conference on Large Scale Optimization, hosted by the Center for Applied Optimization, was held at the University of Florida. The con­ ference was supported by the National Science Foundation, the U. S. Army Research Office, and the University of Florida, with endorsements from SIAM, MPS, ORSA and IMACS. Forty one invited speakers presented papers on mathematical program­ ming and optimal control topics with an emphasis on algorithm development, real world applications and numerical results. Participants from Canada, Japan, Sweden, The Netherlands, Germany, Belgium, Greece, and Denmark gave the meeting an important international component. At­ tendees also included representatives from IBM, American Airlines, US Air, United Parcel Serice, AT & T Bell Labs, Thinking Machines, Army High Performance Com­ puting Research Center, and Argonne National Laboratory. In addition, the NSF sponsored attendance of thirteen graduate students from universities in the United States and abro...

  2. Large scale nuclear structure studies

    International Nuclear Information System (INIS)

    Faessler, A.

    1985-01-01

    Results of large scale nuclear structure studies are reported. The starting point is the Hartree-Fock-Bogoliubov solution with angular momentum and proton and neutron number projection after variation. This model for number and spin projected two-quasiparticle excitations with realistic forces yields in sd-shell nuclei similar good results as the 'exact' shell-model calculations. Here the authors present results for a pf-shell nucleus 46 Ti and results for the A=130 mass region where they studied 58 different nuclei with the same single-particle energies and the same effective force derived from a meson exchange potential. They carried out a Hartree-Fock-Bogoliubov variation after mean field projection in realistic model spaces. In this way, they determine for each yrast state the optimal mean Hartree-Fock-Bogoliubov field. They apply this method to 130 Ce and 128 Ba using the same effective nucleon-nucleon interaction. (Auth.)

  3. Large-scale river regulation

    International Nuclear Information System (INIS)

    Petts, G.

    1994-01-01

    Recent concern over human impacts on the environment has tended to focus on climatic change, desertification, destruction of tropical rain forests, and pollution. Yet large-scale water projects such as dams, reservoirs, and inter-basin transfers are among the most dramatic and extensive ways in which our environment has been, and continues to be, transformed by human action. Water running to the sea is perceived as a lost resource, floods are viewed as major hazards, and wetlands are seen as wastelands. River regulation, involving the redistribution of water in time and space, is a key concept in socio-economic development. To achieve water and food security, to develop drylands, and to prevent desertification and drought are primary aims for many countries. A second key concept is ecological sustainability. Yet the ecology of rivers and their floodplains is dependent on the natural hydrological regime, and its related biochemical and geomorphological dynamics. (Author)

  4. Reviving large-scale projects

    International Nuclear Information System (INIS)

    Desiront, A.

    2003-01-01

    For the past decade, most large-scale hydro development projects in northern Quebec have been put on hold due to land disputes with First Nations. Hydroelectric projects have recently been revived following an agreement signed with Aboriginal communities in the province who recognized the need to find new sources of revenue for future generations. Many Cree are working on the project to harness the waters of the Eastmain River located in the middle of their territory. The work involves building an 890 foot long dam, 30 dikes enclosing a 603 square-km reservoir, a spillway, and a power house with 3 generating units with a total capacity of 480 MW of power for start-up in 2007. The project will require the use of 2,400 workers in total. The Cree Construction and Development Company is working on relations between Quebec's 14,000 Crees and the James Bay Energy Corporation, the subsidiary of Hydro-Quebec which is developing the project. Approximately 10 per cent of the $735-million project has been designated for the environmental component. Inspectors ensure that the project complies fully with environmental protection guidelines. Total development costs for Eastmain-1 are in the order of $2 billion of which $735 million will cover work on site and the remainder will cover generating units, transportation and financial charges. Under the treaty known as the Peace of the Braves, signed in February 2002, the Quebec government and Hydro-Quebec will pay the Cree $70 million annually for 50 years for the right to exploit hydro, mining and forest resources within their territory. The project comes at a time when electricity export volumes to the New England states are down due to growth in Quebec's domestic demand. Hydropower is a renewable and non-polluting source of energy that is one of the most acceptable forms of energy where the Kyoto Protocol is concerned. It was emphasized that large-scale hydro-electric projects are needed to provide sufficient energy to meet both

  5. Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery.

    Science.gov (United States)

    Zhao, Hongyan; Zhao, Hongying; Wang, Yu; Jing, Huang; Ding, Qian; Xue, Jun

    2013-09-01

    Significant malnutrition exists in a high percentage of patients with gastric cancer. It is, therefore, crucial to establish an effective means to provide nutrition for these patients. This prospective, randomized, double-blinded clinical trial aims to assess the long-term survival of arginine-supplementation enteral nutrition versus standard enteral nutrition in malnourished patients with gastric cancer. The control group (36 cases) received postoperative standard enteral nutrition. Meanwhile, the arginine-supplementation group (37 cases) adopted the same nutrition product but enriched with arginine (9.0 g/L). The primary study objective was overall survival (OS). Secondary endpoints were progression-free survival (PFS); serum parameters including total protein, albumin, proalbumin, and transferrin obtained on preoperative day 1, postoperative day 2, and day 12; CD4(+) and CD8(+) T cells, natural killer (NK) cells, immunoglobulin M (IgM), and immunoglobulin G (IgG) obtained on preoperative day 1 and postoperative day 7. No significant differences in baseline characteristics were observed between groups. The group receiving arginine-enriched nutrition had a significantly better OS (P = 0.03, 41 vs. 30.5 months) and better PFS (P = 0.02, 18 vs. 11.5 months). On postoperative day 7, CD4(+) T cells, NK cells, IgM and IgG levels of the arginine-supplemented group increased prominently and were significantly higher than those of the control group and those on preoperative day 1. There is no significant difference in the serum total protein, albumin, proalbumin, and transferrin levels between the two arms. Arginine-supplemented enteral nutrition significantly improves long-term survival and restores immunity in malnourished gastric cancer.

  6. Large Scale Glazed Concrete Panels

    DEFF Research Database (Denmark)

    Bache, Anja Margrethe

    2010-01-01

    Today, there is a lot of focus on concrete surface’s aesthitic potential, both globally and locally. World famous architects such as Herzog De Meuron, Zaha Hadid, Richard Meyer and David Chippenfield challenge the exposure of concrete in their architecture. At home, this trend can be seen...... in the crinkly façade of DR-Byen (the domicile of the Danish Broadcasting Company) by architect Jean Nouvel and Zaha Hadid’s Ordrupgård’s black curved smooth concrete surfaces. Furthermore, one can point to initiatives such as “Synlig beton” (visible concrete) that can be seen on the website www.......synligbeton.dk and spæncom’s aesthetic relief effects by the designer Line Kramhøft (www.spaencom.com). It is my hope that the research-development project “Lasting large scale glazed concrete formwork,” I am working on at DTU, department of Architectural Engineering will be able to complement these. It is a project where I...

  7. Large scale cluster computing workshop

    International Nuclear Information System (INIS)

    Dane Skow; Alan Silverman

    2002-01-01

    Recent revolutions in computer hardware and software technologies have paved the way for the large-scale deployment of clusters of commodity computers to address problems heretofore the domain of tightly coupled SMP processors. Near term projects within High Energy Physics and other computing communities will deploy clusters of scale 1000s of processors and be used by 100s to 1000s of independent users. This will expand the reach in both dimensions by an order of magnitude from the current successful production facilities. The goals of this workshop were: (1) to determine what tools exist which can scale up to the cluster sizes foreseen for the next generation of HENP experiments (several thousand nodes) and by implication to identify areas where some investment of money or effort is likely to be needed. (2) To compare and record experimences gained with such tools. (3) To produce a practical guide to all stages of planning, installing, building and operating a large computing cluster in HENP. (4) To identify and connect groups with similar interest within HENP and the larger clustering community

  8. Large scale cross hole testing

    International Nuclear Information System (INIS)

    Ball, J.K.; Black, J.H.; Doe, T.

    1991-05-01

    As part of the Site Characterisation and Validation programme the results of the large scale cross hole testing have been used to document hydraulic connections across the SCV block, to test conceptual models of fracture zones and obtain hydrogeological properties of the major hydrogeological features. The SCV block is highly heterogeneous. This heterogeneity is not smoothed out even over scales of hundreds of meters. Results of the interpretation validate the hypothesis of the major fracture zones, A, B and H; not much evidence of minor fracture zones is found. The uncertainty in the flow path, through the fractured rock, causes sever problems in interpretation. Derived values of hydraulic conductivity were found to be in a narrow range of two to three orders of magnitude. Test design did not allow fracture zones to be tested individually. This could be improved by testing the high hydraulic conductivity regions specifically. The Piezomac and single hole equipment worked well. Few, if any, of the tests ran long enough to approach equilibrium. Many observation boreholes showed no response. This could either be because there is no hydraulic connection, or there is a connection but a response is not seen within the time scale of the pumping test. The fractional dimension analysis yielded credible results, and the sinusoidal testing procedure provided an effective means of identifying the dominant hydraulic connections. (10 refs.) (au)

  9. Large-scale pool fires

    Directory of Open Access Journals (Sweden)

    Steinhaus Thomas

    2007-01-01

    Full Text Available A review of research into the burning behavior of large pool fires and fuel spill fires is presented. The features which distinguish such fires from smaller pool fires are mainly associated with the fire dynamics at low source Froude numbers and the radiative interaction with the fire source. In hydrocarbon fires, higher soot levels at increased diameters result in radiation blockage effects around the perimeter of large fire plumes; this yields lower emissive powers and a drastic reduction in the radiative loss fraction; whilst there are simplifying factors with these phenomena, arising from the fact that soot yield can saturate, there are other complications deriving from the intermittency of the behavior, with luminous regions of efficient combustion appearing randomly in the outer surface of the fire according the turbulent fluctuations in the fire plume. Knowledge of the fluid flow instabilities, which lead to the formation of large eddies, is also key to understanding the behavior of large-scale fires. Here modeling tools can be effectively exploited in order to investigate the fluid flow phenomena, including RANS- and LES-based computational fluid dynamics codes. The latter are well-suited to representation of the turbulent motions, but a number of challenges remain with their practical application. Massively-parallel computational resources are likely to be necessary in order to be able to adequately address the complex coupled phenomena to the level of detail that is necessary.

  10. Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: a longitudinal cohort study and validation.

    Science.gov (United States)

    Latourelle, Jeanne C; Beste, Michael T; Hadzi, Tiffany C; Miller, Robert E; Oppenheim, Jacob N; Valko, Matthew P; Wuest, Diane M; Church, Bruce W; Khalil, Iya G; Hayete, Boris; Venuto, Charles S

    2017-11-01

    Better understanding and prediction of progression of Parkinson's disease could improve disease management and clinical trial design. We aimed to use longitudinal clinical, molecular, and genetic data to develop predictive models, compare potential biomarkers, and identify novel predictors for motor progression in Parkinson's disease. We also sought to assess the use of these models in the design of treatment trials in Parkinson's disease. A Bayesian multivariate predictive inference platform was applied to data from the Parkinson's Progression Markers Initiative (PPMI) study (NCT01141023). We used genetic data and baseline molecular and clinical variables from patients with Parkinson's disease and healthy controls to construct an ensemble of models to predict the annual rate of change in combined scores from the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts II and III. We tested our overall explanatory power, as assessed by the coefficient of determination (R 2 ), and replicated novel findings in an independent clinical cohort from the Longitudinal and Biomarker Study in Parkinson's disease (LABS-PD; NCT00605163). The potential utility of these models for clinical trial design was quantified by comparing simulated randomised placebo-controlled trials within the out-of-sample LABS-PD cohort. 117 healthy controls and 312 patients with Parkinson's disease from the PPMI study were available for analysis, and 317 patients with Parkinson's disease from LABS-PD were available for validation. Our model ensemble showed strong performance within the PPMI cohort (five-fold cross-validated R 2 41%, 95% CI 35-47) and significant-albeit reduced-performance in the LABS-PD cohort (R 2 9%, 95% CI 4-16). Individual predictive features identified from PPMI data were confirmed in the LABS-PD cohort. These included significant replication of higher baseline MDS-UPDRS motor score, male sex, and increased age, as well as a novel Parkinson's disease

  11. Systematic review of the global epidemiology, clinical and laboratory profile of enteric fever

    Directory of Open Access Journals (Sweden)

    Asma Azmatullah

    2015-12-01

    Full Text Available Children suffer the highest burden of enteric fever among populations in South Asian countries. The clinical features are non–specific, vary in populations, and are often difficult to distinguish clinically from other febrile illnesses, leading to delayed or inappropriate diagnosis and treatment. We undertook a systematic review to assess the clinical profile and laboratory features of enteric fever across age groups, economic regions, level of care and antibiotic susceptibility patterns.

  12. Large-scale galaxy bias

    Science.gov (United States)

    Desjacques, Vincent; Jeong, Donghui; Schmidt, Fabian

    2018-02-01

    This review presents a comprehensive overview of galaxy bias, that is, the statistical relation between the distribution of galaxies and matter. We focus on large scales where cosmic density fields are quasi-linear. On these scales, the clustering of galaxies can be described by a perturbative bias expansion, and the complicated physics of galaxy formation is absorbed by a finite set of coefficients of the expansion, called bias parameters. The review begins with a detailed derivation of this very important result, which forms the basis of the rigorous perturbative description of galaxy clustering, under the assumptions of General Relativity and Gaussian, adiabatic initial conditions. Key components of the bias expansion are all leading local gravitational observables, which include the matter density but also tidal fields and their time derivatives. We hence expand the definition of local bias to encompass all these contributions. This derivation is followed by a presentation of the peak-background split in its general form, which elucidates the physical meaning of the bias parameters, and a detailed description of the connection between bias parameters and galaxy statistics. We then review the excursion-set formalism and peak theory which provide predictions for the values of the bias parameters. In the remainder of the review, we consider the generalizations of galaxy bias required in the presence of various types of cosmological physics that go beyond pressureless matter with adiabatic, Gaussian initial conditions: primordial non-Gaussianity, massive neutrinos, baryon-CDM isocurvature perturbations, dark energy, and modified gravity. Finally, we discuss how the description of galaxy bias in the galaxies' rest frame is related to clustering statistics measured from the observed angular positions and redshifts in actual galaxy catalogs.

  13. Large-scale galaxy bias

    Science.gov (United States)

    Jeong, Donghui; Desjacques, Vincent; Schmidt, Fabian

    2018-01-01

    Here, we briefly introduce the key results of the recent review (arXiv:1611.09787), whose abstract is as following. This review presents a comprehensive overview of galaxy bias, that is, the statistical relation between the distribution of galaxies and matter. We focus on large scales where cosmic density fields are quasi-linear. On these scales, the clustering of galaxies can be described by a perturbative bias expansion, and the complicated physics of galaxy formation is absorbed by a finite set of coefficients of the expansion, called bias parameters. The review begins with a detailed derivation of this very important result, which forms the basis of the rigorous perturbative description of galaxy clustering, under the assumptions of General Relativity and Gaussian, adiabatic initial conditions. Key components of the bias expansion are all leading local gravitational observables, which include the matter density but also tidal fields and their time derivatives. We hence expand the definition of local bias to encompass all these contributions. This derivation is followed by a presentation of the peak-background split in its general form, which elucidates the physical meaning of the bias parameters, and a detailed description of the connection between bias parameters and galaxy (or halo) statistics. We then review the excursion set formalism and peak theory which provide predictions for the values of the bias parameters. In the remainder of the review, we consider the generalizations of galaxy bias required in the presence of various types of cosmological physics that go beyond pressureless matter with adiabatic, Gaussian initial conditions: primordial non-Gaussianity, massive neutrinos, baryon-CDM isocurvature perturbations, dark energy, and modified gravity. Finally, we discuss how the description of galaxy bias in the galaxies' rest frame is related to clustering statistics measured from the observed angular positions and redshifts in actual galaxy catalogs.

  14. Technology for Large-Scale Translation of Clinical Practice Guidelines: A Pilot Study of the Performance of a Hybrid Human and Computer-Assisted Approach.

    Science.gov (United States)

    Van de Velde, Stijn; Macken, Lieve; Vanneste, Koen; Goossens, Martine; Vanschoenbeek, Jan; Aertgeerts, Bert; Vanopstal, Klaar; Vander Stichele, Robert; Buysschaert, Joost

    2015-10-09

    translation acceptability and adequacy. The average number of words per guideline was 1195 and the mean total translation time was 100.2 minutes/1000 words. No meaningful differences were found in the translation speed for new guidelines. The translation of updated guidelines was 59 minutes/1000 words faster (95% CI 2-115; P=.044) in the computer-aided group. Revisions due to terminology accounted for one third of the overall revisions by the medical proofreader. Use of the hybrid human and computer-aided translation by a non-expert translator makes the translation of updates of clinical practice guidelines faster and cheaper because of the benefits of translation memory. For the translation of new guidelines, there was no apparent benefit in comparison with the efficiency of translation unsupported by translation memory (whether by an expert or non-expert translator).

  15. Overcoming the bottleneck of platelet lysate supply in large-scale clinical expansion of adipose-derived stem cells: A comparison of fresh versus three types of platelet lysates from outdated buffy coat-derived platelet concentrates.

    Science.gov (United States)

    Glovinski, Peter V; Herly, Mikkel; Mathiasen, Anders B; Svalgaard, Jesper D; Borup, Rehannah; Talman, Maj-Lis M; Elberg, Jens J; Kølle, Stig-Frederik T; Drzewiecki, Krzysztof T; Fischer-Nielsen, Anne

    2017-02-01

    Platelet lysates (PL) represent a promising replacement for xenogenic growth supplement for adipose-derived stem cell (ASC) expansions. However, fresh platelets from human blood donors are not clinically feasible for large-scale cell expansion based on their limited supply. Therefore, we tested PLs prepared via three methods from outdated buffy coat-derived platelet concentrates (PCs) to establish an efficient and feasible expansion of ASCs for clinical use. PLs were prepared by the freeze-thaw method from freshly drawn platelets or from outdated buffy coat-derived PCs stored in the platelet additive solution, InterSol. Three types of PLs were prepared from outdated PCs with platelets suspended in either (1) InterSol (not manipulated), (2) InterSol + supplemented with plasma or (3) plasma alone (InterSol removed). Using these PLs, we compared ASC population doubling time, cell yield, differentiation potential and cell surface markers. Gene expression profiles were analyzed using microarray assays, and growth factor concentrations in the cell culture medium were measured using enzyme-linked immunosorbent assay (ELISA). Of the three PL compositions produced from outdated PCs, removal of Intersol and resuspension in plasma prior to the first freezing process was overall the best. This specific outdated PL induced ASC growth kinetics, surface markers, plastic adherence and differentiation potentials comparable with PL from fresh platelets. ASCs expanded in PL from fresh versus outdated PCs exhibited different expressions of 17 overlapping genes, of which 10 were involved in cellular proliferation, although not significantly reflected by cell growth. Only minor differences in growth factor turnover were observed. PLs from outdated platelets may be an efficient and reliable source of human growth supplement allowing for large-scale ASC expansion for clinical use. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights

  16. Permissive or Trophic Enteral Nutrition and Full Enteral Nutrition Had Similar Effects on Clinical Outcomes in Intensive Care: A Systematic Review of Randomized Clinical Trials.

    Science.gov (United States)

    Silva, Camila F A; de Vasconcelos, Simone G; da Silva, Thales A; Silva, Flávia M

    2018-01-26

    The aim of this study was to systematically review the effect of permissive underfeeding/trophic feeding on the clinical outcomes of critically ill patients. A systematic review of randomized clinical trials to evaluate the mortality, length of stay, and mechanical ventilation duration in patients randomized to either hypocaloric or full-energy enteral nutrition was performed. Data sources included PubMed and Scopus and the reference lists of the articles retrieved. Two independent reviewers participated in all phases of this systematic review as proposed by the Cochrane Handbook, and the review was reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 7 randomized clinical trials that included a total of 1,717 patients were reviewed. Intensive care unit length of stay and mechanical ventilation duration were not statistically different between the intervention and control groups in all randomized clinical trials, and mortality rate was also not different between the groups. In conclusion, hypocaloric enteral nutrition had no significantly different effects on morbidity and mortality in critically ill patients when compared with full-energy nutrition. It is still necessary to determine the safety of this intervention in this group of patients, the optimal amount of energy provided, and the duration of this therapy. © 2018 American Society for Parenteral and Enteral Nutrition.

  17. Ethics of large-scale change

    OpenAIRE

    Arler, Finn

    2006-01-01

      The subject of this paper is long-term large-scale changes in human society. Some very significant examples of large-scale change are presented: human population growth, human appropriation of land and primary production, the human use of fossil fuels, and climate change. The question is posed, which kind of attitude is appropriate when dealing with large-scale changes like these from an ethical point of view. Three kinds of approaches are discussed: Aldo Leopold's mountain thinking, th...

  18. Large Scale Computations in Air Pollution Modelling

    DEFF Research Database (Denmark)

    Zlatev, Z.; Brandt, J.; Builtjes, P. J. H.

    Proceedings of the NATO Advanced Research Workshop on Large Scale Computations in Air Pollution Modelling, Sofia, Bulgaria, 6-10 July 1998......Proceedings of the NATO Advanced Research Workshop on Large Scale Computations in Air Pollution Modelling, Sofia, Bulgaria, 6-10 July 1998...

  19. Automating large-scale reactor systems

    International Nuclear Information System (INIS)

    Kisner, R.A.

    1985-01-01

    This paper conveys a philosophy for developing automated large-scale control systems that behave in an integrated, intelligent, flexible manner. Methods for operating large-scale systems under varying degrees of equipment degradation are discussed, and a design approach that separates the effort into phases is suggested. 5 refs., 1 fig

  20. Decentralized Large-Scale Power Balancing

    DEFF Research Database (Denmark)

    Halvgaard, Rasmus; Jørgensen, John Bagterp; Poulsen, Niels Kjølstad

    2013-01-01

    problem is formulated as a centralized large-scale optimization problem but is then decomposed into smaller subproblems that are solved locally by each unit connected to an aggregator. For large-scale systems the method is faster than solving the full problem and can be distributed to include an arbitrary...

  1. Changes and clinical significance of liver function and myocardial zymogram in children with rotavirus enteritis

    Directory of Open Access Journals (Sweden)

    Lan-Ping Yang

    2016-12-01

    Full Text Available Objective: To explore the changes and clinical significance of liver function and myocardial zymogram in children with rotavirus (RV enteritis. Methods: A total of 70 children with RV enteritis who were admitted in our hospital were included in the study and served as the observation group. The liver function and myocardial zymogram before and after treatment were detected. The proportion of RV enteritis children with liver and myocardial damage was calculated. The effect of dehydration on the liver function and myocardial zymogram in children with RV enteritis was analyzed. A total of 65 children with non-RV enteritis who were admitted in our hospital at the same stage were served as the control group. Results: The serum ALT, AST, CK, CK-MB, LDH, and α-HBDH levels, and liver myocardial damage children proportion in the observation group were significantly higher than those in the control group (P<0.05. The serum ALT, AST, CK, CK-MB, LDH, and α-HBDH levels in the observation group were significantly elevated with the acceleration of dehydration degree (P<0.05. In the observation group, 45 children had liver and myocardial damage, whose ALT, AST, CK, CKMB, LDH, and α-HBDH levels after treatment were significantly reduced when compared with before treatment (P<0.05. Conclusions: Early detection of liver function and myocardial zymogram can accurately reflect the condition in children with RV enteritis, which can provide an evidence for the formulation of clinical treatment protocol.

  2. Large scale network-centric distributed systems

    CERN Document Server

    Sarbazi-Azad, Hamid

    2014-01-01

    A highly accessible reference offering a broad range of topics and insights on large scale network-centric distributed systems Evolving from the fields of high-performance computing and networking, large scale network-centric distributed systems continues to grow as one of the most important topics in computing and communication and many interdisciplinary areas. Dealing with both wired and wireless networks, this book focuses on the design and performance issues of such systems. Large Scale Network-Centric Distributed Systems provides in-depth coverage ranging from ground-level hardware issu

  3. Clinical characteristics and oncological outcomes of testicular cancer patients registered in 2005 and 2008: the first large-scale study from the Cancer Registration Committee of the Japanese Urological Association.

    Science.gov (United States)

    Miki, Tsuneharu; Kamoi, Kazumi; Fujimoto, Hiroyuki; Kanayama, Hiro-omi; Ohyama, Chikara; Suzuki, Kazuhiro; Nishiyama, Hiroyuki; Eto, Masatoshi; Naito, Seiji; Fukumori, Tomoharu; Kubota, Yoshinobu; Takahashi, Satoru; Mikami, Kazuya; Homma, Yukio

    2014-08-01

    To describe the clinical and pathological characteristics and oncological outcomes of testicular cancer diagnosed in Japan, we report the results of the testicular cancer registration carried out by the Japanese Urological Association. Testicular cancer survey was conducted by the Japanese Urological Association in 2011 to register newly diagnosed testicular cancers in 2005 and 2008. The survey included details such as age, presenting symptoms, physical examination findings, tumor markers, histopathology, clinical stage, initial treatment and clinical outcomes. We analyzed 1121 cases of testicular primary germ cell tumor among 1157 registered patients. The median age was 37.0 years. Seminomas and non-seminomatous germ cell tumors accounted for 61.9% and 38.1%, respectively. Measurements of tumor markers were documented in 98.6% of the patients; however, there was an unsatisfactory uniform measurement of human chorionic gonadotropin, which made it difficult to evaluate the International Germ Cell Consensus Classification in all patients. The 1- and 3-year overall survival rates from the entire cohort were 98.3% and 96.8%, respectively. According to the International Germ Cell Consensus Classification, 3-year overall survival rates in the good, intermediate, and poor prognosis group were 99.1%, 100% and 79.9%, respectively. The present report is the first large-scale study of the characteristics and survival of testicular cancer patients in Japan based on multi-institutional registry data, and showed a good prognosis even in an advanced stage. The improved survival attributed substantially to accurate diagnosis and effective multimodal treatment. © 2014 The Japanese Urological Association.

  4. Large-scale numerical simulations of plasmas

    International Nuclear Information System (INIS)

    Hamaguchi, Satoshi

    2004-01-01

    The recent trend of large scales simulations of fusion plasma and processing plasmas is briefly summarized. Many advanced simulation techniques have been developed for fusion plasmas and some of these techniques are now applied to analyses of processing plasmas. (author)

  5. Superconducting materials for large scale applications

    International Nuclear Information System (INIS)

    Dew-Hughes, D.

    1975-01-01

    Applications of superconductors capable of carrying large current densities in large-scale electrical devices are examined. Discussions are included on critical current density, superconducting materials available, and future prospects for improved superconducting materials. (JRD)

  6. Large-scale computing with Quantum Espresso

    International Nuclear Information System (INIS)

    Giannozzi, P.; Cavazzoni, C.

    2009-01-01

    This paper gives a short introduction to Quantum Espresso: a distribution of software for atomistic simulations in condensed-matter physics, chemical physics, materials science, and to its usage in large-scale parallel computing.

  7. Large-scale regions of antimatter

    International Nuclear Information System (INIS)

    Grobov, A. V.; Rubin, S. G.

    2015-01-01

    Amodified mechanism of the formation of large-scale antimatter regions is proposed. Antimatter appears owing to fluctuations of a complex scalar field that carries a baryon charge in the inflation era

  8. Large-scale regions of antimatter

    Energy Technology Data Exchange (ETDEWEB)

    Grobov, A. V., E-mail: alexey.grobov@gmail.com; Rubin, S. G., E-mail: sgrubin@mephi.ru [National Research Nuclear University MEPhI (Russian Federation)

    2015-07-15

    Amodified mechanism of the formation of large-scale antimatter regions is proposed. Antimatter appears owing to fluctuations of a complex scalar field that carries a baryon charge in the inflation era.

  9. Large-scale grid management; Storskala Nettforvaltning

    Energy Technology Data Exchange (ETDEWEB)

    Langdal, Bjoern Inge; Eggen, Arnt Ove

    2003-07-01

    The network companies in the Norwegian electricity industry now have to establish a large-scale network management, a concept essentially characterized by (1) broader focus (Broad Band, Multi Utility,...) and (2) bigger units with large networks and more customers. Research done by SINTEF Energy Research shows so far that the approaches within large-scale network management may be structured according to three main challenges: centralization, decentralization and out sourcing. The article is part of a planned series.

  10. Political consultation and large-scale research

    International Nuclear Information System (INIS)

    Bechmann, G.; Folkers, H.

    1977-01-01

    Large-scale research and policy consulting have an intermediary position between sociological sub-systems. While large-scale research coordinates science, policy, and production, policy consulting coordinates science, policy and political spheres. In this very position, large-scale research and policy consulting lack of institutional guarantees and rational back-ground guarantee which are characteristic for their sociological environment. This large-scale research can neither deal with the production of innovative goods under consideration of rentability, nor can it hope for full recognition by the basis-oriented scientific community. Policy consulting knows neither the competence assignment of the political system to make decisions nor can it judge succesfully by the critical standards of the established social science, at least as far as the present situation is concerned. This intermediary position of large-scale research and policy consulting has, in three points, a consequence supporting the thesis which states that this is a new form of institutionalization of science: These are: 1) external control, 2) the organization form, 3) the theoretical conception of large-scale research and policy consulting. (orig.) [de

  11. Clinical and microbiological profile of a retrospective cohort of enteric fever in 2 Spanish tertiary hospitals.

    Science.gov (United States)

    Sánchez-Montalvá, Adrián; Martínez-Pérez, Ángela; Pérez-Molina, José Antonio; González-López, Juan José; Lopez-Vélez, Rogelio; Salvador, Fernando; Sánchez, Irene; Planes, Anna M; Molina, Israel

    2015-05-01

    Enteric fever in high-income countries is diagnosed mainly in patients returning from endemic countries. We assess the clinical, microbiological, and prognosis aspects of enteric fever in 2 Spanish tertiary hospitals. A retrospective observational study was conducted at Vall d'Hebron University Hospital and Ramón y Cajal University Hospital in Spain. We reviewed medical records of all patients who were diagnosed with enteric fever from January 2000 to January 2014 at these hospitals. We identified 47 patients with enteric fever episodes. According to their travel history, 35 (74.5%) patients had travelled to highly endemic countries. Imported enteric fever was acquired mainly in Asia (70.3%). Imported infections were implicated in travelers (48.6%), visiting friends and relatives (40%) and immigrants (11.4%). We found that 12 patients were diagnosed with enteric fever without a travel history (autochthonous infection). The resistance profile of the isolates showed decreased ciprofloxacin susceptibility in 66.7% of the imported group and 8.3% of the autochthonous group (P = 0.001). Salmonella strains from patients returning from Asia had an increased risk of having decreased ciprofloxacin susceptibility (odds ratio, 52.25; 95% confidence interval: 8.6-317.7). Patients with imported enteric fever are at higher risk for having a Salmonella strain with decreased ciprofloxacin susceptibility, especially in patients returning from Asia. Initial treatment with third-generation cephalosporin or azithromycin is strongly recommended until a drug-susceptibility test is available. Prevention strategies such as pretravel counseling and immunization before travel may be beneficial.

  12. Clinical review: optimizing enteral nutrition for critically ill patients - a simple data-driven formula

    Science.gov (United States)

    2011-01-01

    In modern critical care, the paradigm of 'therapeutic nutrition' is replacing traditional 'supportive nutrition'. Standard enteral formulas meet basic macro- and micronutrient needs; therapeutic enteral formulas meet these basic needs and also contain specific pharmaconutrients that may attenuate hyperinflammatory responses, enhance the immune responses to infection, or improve gastrointestinal tolerance. Choosing the right enteral feeding formula may positively affect a patient's outcome; targeted use of therapeutic formulas can reduce the incidence of infectious complications, shorten lengths of stay in the ICU and in the hospital, and lower risk for mortality. In this paper, we review principles of how to feed (enteral, parenteral, or both) and when to feed (early versus delayed start) patients who are critically ill. We discuss what to feed these patients in the context of specific pharmaconutrients in specialized feeding formulations, that is, arginine, glutamine, antioxidants, certain ω-3 and ω-6 fatty acids, hydrolyzed proteins, and medium-chain triglycerides. We summarize current expert guidelines for nutrition in patients with critical illness, and we present specific clinical evidence on the use of enteral formulas supplemented with anti-inflammatory or immune-modulating nutrients, and gastrointestinal tolerance-promoting nutritional formulas. Finally, we introduce an algorithm to help bedside clinicians make data-driven feeding decisions for patients with critical illness. PMID:22136305

  13. Dissecting the large-scale galactic conformity

    Science.gov (United States)

    Seo, Seongu

    2018-01-01

    Galactic conformity is an observed phenomenon that galaxies located in the same region have similar properties such as star formation rate, color, gas fraction, and so on. The conformity was first observed among galaxies within in the same halos (“one-halo conformity”). The one-halo conformity can be readily explained by mutual interactions among galaxies within a halo. Recent observations however further witnessed a puzzling connection among galaxies with no direct interaction. In particular, galaxies located within a sphere of ~5 Mpc radius tend to show similarities, even though the galaxies do not share common halos with each other ("two-halo conformity" or “large-scale conformity”). Using a cosmological hydrodynamic simulation, Illustris, we investigate the physical origin of the two-halo conformity and put forward two scenarios. First, back-splash galaxies are likely responsible for the large-scale conformity. They have evolved into red galaxies due to ram-pressure stripping in a given galaxy cluster and happen to reside now within a ~5 Mpc sphere. Second, galaxies in strong tidal field induced by large-scale structure also seem to give rise to the large-scale conformity. The strong tides suppress star formation in the galaxies. We discuss the importance of the large-scale conformity in the context of galaxy evolution.

  14. Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention

    Directory of Open Access Journals (Sweden)

    Mylonakis ME

    2016-07-01

    Full Text Available Mathios E Mylonakis, Iris Kalli, Timoleon S Rallis Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece  Abstract: Canine parvovirus type 2 is the cause of a highly contagious acute enteritis associated with high morbidity and mortality, with very low survival rates in untreated dogs. Although severe clinical disease typically occurs in dogs younger than 6 months of age, adults with insufficient immunity may potentially be affected. In this article, the current state of knowledge is reviewed regarding the diagnostic aspects of parvoviral enteritis, with special emphasis placed on the clinical relevance of the detection of viral antigens in the feces, detection of viral antibodies in the serum, or the polymerase chain reaction-based amplification of the viral DNA in the feces. In addition, the components of the supportive and symptomatic treatment aiming to optimize the outcome of the disease in the clinical setting are thoroughly reviewed. Immunization guidelines for the prevention of the disease are also updated. Keywords: dog, parvovirus type 2, acute enteritis, treatment, vaccination

  15. Growth Limits in Large Scale Networks

    DEFF Research Database (Denmark)

    Knudsen, Thomas Phillip

    limitations. The rising complexity of network management with the convergence of communications platforms is shown as problematic for both automatic management feasibility and for manpower resource management. In the fourth step the scope is extended to include the present society with the DDN project as its......The Subject of large scale networks is approached from the perspective of the network planner. An analysis of the long term planning problems is presented with the main focus on the changing requirements for large scale networks and the potential problems in meeting these requirements. The problems...... the fundamental technological resources in network technologies are analysed for scalability. Here several technological limits to continued growth are presented. The third step involves a survey of major problems in managing large scale networks given the growth of user requirements and the technological...

  16. Managing large-scale models: DBS

    International Nuclear Information System (INIS)

    1981-05-01

    A set of fundamental management tools for developing and operating a large scale model and data base system is presented. Based on experience in operating and developing a large scale computerized system, the only reasonable way to gain strong management control of such a system is to implement appropriate controls and procedures. Chapter I discusses the purpose of the book. Chapter II classifies a broad range of generic management problems into three groups: documentation, operations, and maintenance. First, system problems are identified then solutions for gaining management control are disucssed. Chapters III, IV, and V present practical methods for dealing with these problems. These methods were developed for managing SEAS but have general application for large scale models and data bases

  17. Accelerating sustainability in large-scale facilities

    CERN Multimedia

    Marina Giampietro

    2011-01-01

    Scientific research centres and large-scale facilities are intrinsically energy intensive, but how can big science improve its energy management and eventually contribute to the environmental cause with new cleantech? CERN’s commitment to providing tangible answers to these questions was sealed in the first workshop on energy management for large scale scientific infrastructures held in Lund, Sweden, on the 13-14 October.   Participants at the energy management for large scale scientific infrastructures workshop. The workshop, co-organised with the European Spallation Source (ESS) and  the European Association of National Research Facilities (ERF), tackled a recognised need for addressing energy issues in relation with science and technology policies. It brought together more than 150 representatives of Research Infrastrutures (RIs) and energy experts from Europe and North America. “Without compromising our scientific projects, we can ...

  18. Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer.

    Science.gov (United States)

    Li, B; Liu, H Y; Guo, S H; Sun, P; Gong, F M; Jia, B Q

    2015-06-29

    The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa-tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group patients received conventional perioperative treatment. Patients' clinical outcomes, post-operative immune function, and nutritional statuses were compared, which revealed that the postoperative fever duration (80.2 ± 6.0 vs 88.1 ± 8.1 h, P 0.05]. At postoperative days 3 and 7, the CD3(+), CD4(+), natural killer cell, albumin, and prealbumin levels and CD4(+)/CD8(+) ra-tio were significantly higher in the experimental group than the control group (all P nutritional status and immune function and promote early recovery of intestinal function in patients with gastric cancer.

  19. Large-Scale Analysis of Art Proportions

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer

    2014-01-01

    While literature often tries to impute mathematical constants into art, this large-scale study (11 databases of paintings and photos, around 200.000 items) shows a different truth. The analysis, consisting of the width/height proportions, shows a value of rarely if ever one (square) and with majo......While literature often tries to impute mathematical constants into art, this large-scale study (11 databases of paintings and photos, around 200.000 items) shows a different truth. The analysis, consisting of the width/height proportions, shows a value of rarely if ever one (square...

  20. The Expanded Large Scale Gap Test

    Science.gov (United States)

    1987-03-01

    NSWC TR 86-32 DTIC THE EXPANDED LARGE SCALE GAP TEST BY T. P. LIDDIARD D. PRICE RESEARCH AND TECHNOLOGY DEPARTMENT ’ ~MARCH 1987 Ap~proved for public...arises, to reduce the spread in the LSGT 50% gap value.) The worst charges, such as those with the highest or lowest densities, the largest re-pressed...Arlington, VA 22217 PE 62314N INS3A 1 RJ14E31 7R4TBK 11 TITLE (Include Security CIlmsilficatiorn The Expanded Large Scale Gap Test . 12. PEIRSONAL AUTHOR() T

  1. Prevalence, risk factors, clinical consequences, and treatment of enteral feed intolerance during critical illness.

    Science.gov (United States)

    Gungabissoon, Usha; Hacquoil, Kimberley; Bains, Chanchal; Irizarry, Michael; Dukes, George; Williamson, Russell; Deane, Adam M; Heyland, Daren K

    2015-05-01

    We aimed to determine the incidence of enteral feed intolerance and factors associated with intolerance and to assess the influence of intolerance on nutrition and clinical outcomes. We conducted a retrospective analysis of data from an international observational cohort study of nutrition practices among 167 intensive care units (ICUs). Data were collected on nutrition adequacy, ventilator-free days (VFDs), ICU stay, and 60-day mortality. Intolerance was defined as interruption of enteral nutrition (EN) due to gastrointestinal (GI) reasons (large gastric residuals, abdominal distension, emesis, diarrhea, or subjective discomfort). Logistic regression was used to determine risk factors for intolerance and their clinical significance. A sensitivity analysis restricted to sites specifying a gastric residual volume ≥200 mL to identify intolerance was also conducted. Data from 1,888 ICU patients were included. The incidence of intolerance was 30.5% and occurred after a median 3 days from EN initiation. Patients remained intolerant for a mean (±SD) duration of 1.9 ± 1.3 days . Intolerance was associated with worse nutrition adequacy vs the tolerant (56% vs 64%, P intolerance remained associated with negative outcomes. Although mortality was greater among the intolerant patients, this was not statistically significant. Intolerance occurs frequently during EN in critically ill patients and is associated with poorer nutrition and clinical outcomes. © 2014 American Society for Parenteral and Enteral Nutrition.

  2. Configuration management in large scale infrastructure development

    NARCIS (Netherlands)

    Rijn, T.P.J. van; Belt, H. van de; Los, R.H.

    2000-01-01

    Large Scale Infrastructure (LSI) development projects such as the construction of roads, rail-ways and other civil engineering (water)works is tendered differently today than a decade ago. Traditional workflow requested quotes from construction companies for construction works where the works to be

  3. Large-scale Motion of Solar Filaments

    Indian Academy of Sciences (India)

    tribpo

    Large-scale Motion of Solar Filaments. Pavel Ambrož, Astronomical Institute of the Acad. Sci. of the Czech Republic, CZ-25165. Ondrejov, The Czech Republic. e-mail: pambroz@asu.cas.cz. Alfred Schroll, Kanzelhöehe Solar Observatory of the University of Graz, A-9521 Treffen,. Austria. e-mail: schroll@solobskh.ac.at.

  4. Sensitivity analysis for large-scale problems

    Science.gov (United States)

    Noor, Ahmed K.; Whitworth, Sandra L.

    1987-01-01

    The development of efficient techniques for calculating sensitivity derivatives is studied. The objective is to present a computational procedure for calculating sensitivity derivatives as part of performing structural reanalysis for large-scale problems. The scope is limited to framed type structures. Both linear static analysis and free-vibration eigenvalue problems are considered.

  5. Ethics of large-scale change

    DEFF Research Database (Denmark)

    Arler, Finn

    2006-01-01

    , which kind of attitude is appropriate when dealing with large-scale changes like these from an ethical point of view. Three kinds of approaches are discussed: Aldo Leopold's mountain thinking, the neoclassical economists' approach, and finally the so-called Concentric Circle Theories approach...

  6. The origin of large scale cosmic structure

    International Nuclear Information System (INIS)

    Jones, B.J.T.; Palmer, P.L.

    1985-01-01

    The paper concerns the origin of large scale cosmic structure. The evolution of density perturbations, the nonlinear regime (Zel'dovich's solution and others), the Gott and Rees clustering hierarchy, the spectrum of condensations, and biassed galaxy formation, are all discussed. (UK)

  7. Large-scale multimedia modeling applications

    International Nuclear Information System (INIS)

    Droppo, J.G. Jr.; Buck, J.W.; Whelan, G.; Strenge, D.L.; Castleton, K.J.; Gelston, G.M.

    1995-08-01

    Over the past decade, the US Department of Energy (DOE) and other agencies have faced increasing scrutiny for a wide range of environmental issues related to past and current practices. A number of large-scale applications have been undertaken that required analysis of large numbers of potential environmental issues over a wide range of environmental conditions and contaminants. Several of these applications, referred to here as large-scale applications, have addressed long-term public health risks using a holistic approach for assessing impacts from potential waterborne and airborne transport pathways. Multimedia models such as the Multimedia Environmental Pollutant Assessment System (MEPAS) were designed for use in such applications. MEPAS integrates radioactive and hazardous contaminants impact computations for major exposure routes via air, surface water, ground water, and overland flow transport. A number of large-scale applications of MEPAS have been conducted to assess various endpoints for environmental and human health impacts. These applications are described in terms of lessons learned in the development of an effective approach for large-scale applications

  8. Large-scale perspective as a challenge

    NARCIS (Netherlands)

    Plomp, M.G.A.

    2012-01-01

    1. Scale forms a challenge for chain researchers: when exactly is something ‘large-scale’? What are the underlying factors (e.g. number of parties, data, objects in the chain, complexity) that determine this? It appears to be a continuum between small- and large-scale, where positioning on that

  9. Computing in Large-Scale Dynamic Systems

    NARCIS (Netherlands)

    Pruteanu, A.S.

    2013-01-01

    Software applications developed for large-scale systems have always been difficult to de- velop due to problems caused by the large number of computing devices involved. Above a certain network size (roughly one hundred), necessary services such as code updating, topol- ogy discovery and data

  10. Learning from large scale neural simulations

    DEFF Research Database (Denmark)

    Serban, Maria

    2017-01-01

    Large-scale neural simulations have the marks of a distinct methodology which can be fruitfully deployed to advance scientific understanding of the human brain. Computer simulation studies can be used to produce surrogate observational data for better conceptual models and new how...

  11. Large-Scale Outflows in Seyfert Galaxies

    Science.gov (United States)

    Colbert, E. J. M.; Baum, S. A.

    1995-12-01

    \\catcode`\\@=11 \\ialign{m @th#1hfil ##hfil \\crcr#2\\crcr\\sim\\crcr}}} \\catcode`\\@=12 Highly collimated outflows extend out to Mpc scales in many radio-loud active galaxies. In Seyfert galaxies, which are radio-quiet, the outflows extend out to kpc scales and do not appear to be as highly collimated. In order to study the nature of large-scale (>~1 kpc) outflows in Seyferts, we have conducted optical, radio and X-ray surveys of a distance-limited sample of 22 edge-on Seyfert galaxies. Results of the optical emission-line imaging and spectroscopic survey imply that large-scale outflows are present in >~{{1} /{4}} of all Seyferts. The radio (VLA) and X-ray (ROSAT) surveys show that large-scale radio and X-ray emission is present at about the same frequency. Kinetic luminosities of the outflows in Seyferts are comparable to those in starburst-driven superwinds. Large-scale radio sources in Seyferts appear diffuse, but do not resemble radio halos found in some edge-on starburst galaxies (e.g. M82). We discuss the feasibility of the outflows being powered by the active nucleus (e.g. a jet) or a circumnuclear starburst.

  12. Stability of large scale interconnected dynamical systems

    International Nuclear Information System (INIS)

    Akpan, E.P.

    1993-07-01

    Large scale systems modelled by a system of ordinary differential equations are considered and necessary and sufficient conditions are obtained for the uniform asymptotic connective stability of the systems using the method of cone-valued Lyapunov functions. It is shown that this model significantly improves the existing models. (author). 9 refs

  13. Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.

    Science.gov (United States)

    Ochoa-Cortes, Fernando; Turco, Fabio; Linan-Rico, Andromeda; Soghomonyan, Suren; Whitaker, Emmett; Wehner, Sven; Cuomo, Rosario; Christofi, Fievos L

    2016-02-01

    The word "glia" is derived from the Greek word "γλoια," glue of the enteric nervous system, and for many years, enteric glial cells (EGCs) were believed to provide mainly structural support. However, EGCs as astrocytes in the central nervous system may serve a much more vital and active role in the enteric nervous system, and in homeostatic regulation of gastrointestinal functions. The emphasis of this review will be on emerging concepts supported by basic, translational, and/or clinical studies, implicating EGCs in neuron-to-glial (neuroglial) communication, motility, interactions with other cells in the gut microenvironment, infection, and inflammatory bowel diseases. The concept of the "reactive glial phenotype" is explored as it relates to inflammatory bowel diseases, bacterial and viral infections, postoperative ileus, functional gastrointestinal disorders, and motility disorders. The main theme of this review is that EGCs are emerging as a new frontier in neurogastroenterology and a potential therapeutic target. New technological innovations in neuroimaging techniques are facilitating progress in the field, and an update is provided on exciting new translational studies. Gaps in our knowledge are discussed for further research. Restoring normal EGC function may prove to be an efficient strategy to dampen inflammation. Probiotics, palmitoylethanolamide (peroxisome proliferator-activated receptor-α), interleukin-1 antagonists (anakinra), and interventions acting on nitric oxide, receptor for advanced glycation end products, S100B, or purinergic signaling pathways are relevant clinical targets on EGCs with therapeutic potential.

  14. Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs.

    Science.gov (United States)

    Lei, Zhixin; Liu, Qianying; Yang, Bing; Xiong, Jincheng; Li, Kun; Ahmed, Saeed; Hong, Liping; Chen, Pin; He, Qigai; Cao, Jiyue

    2017-01-01

    A new, more palatable formulation of 10% enrofloxacin enteric-coated granules was investigated to evaluate the pharmacokinetic effect in plasma, the residue elimination in tissues and the clinical efficacy against Actinobacillus pleuropneumonia (APP) and Mycoplasam suis (MS) in pigs. In this study, the enrofloxacin concentrations in plasma and tissues were detected using high-performance liquid chromatography with phosphate buffer (pH = 3) and acetonitrile. The pharmacokinetics and elimination of enrofloxacin enteric-coated granules were performed after oral administration at a single dose of 10 mg/kg body weight (bw) and 5 mg/kg twice per day for 5 consecutive days, respectively. The in vivo antibacterial efficacy and clinical effectiveness of enrofloxacin enteric-coated granules against APP and MS were assayed at 2.5, 5, 10 mg/kg, compared with tiamulin (8 mg/kg) based on establishment of APP and MS infection models. 56 APP strains were selected and tested for in vitro antibacterial activity of enrofloxacin enteric-coated granules. The main parameters of elimination half-life (t 1/2β ), T max , and area under the curve (AUC) were 14.99 ± 4.19, 3.99 ± 0.10, and 38.93 ± 1.52 μg h/ml, respectively, revealing that the enrofloxacin concentration remained high and with a sustainable distribution in plasma. Moreover, the analysis on the evaluation of enrofloxacin and ciprofloxacin in muscle, fat, liver and kidney showed that the recovery were more than 84% recovery in accordance with the veterinary drug residue guidelines of United States pharmacopeia, and the withdrawal periods were 4.28, 3.81, 4.84, and 3.51 days, respectively, suggesting that the withdrawal period was 5 d after oral administration of 5 mg/kg twice per day. The optimal dosage of enrofloxacin enteric-coated granules against APP and MS was 5 mg/kg, with over 90% efficacy, which was significantly different ( p enrofloxacin enteric-coated granules had significant potential for treating APP and MS

  15. Clinical Efficacy and Residue Depletion of 10% Enrofloxacin Enteric-Coated Granules in Pigs

    Directory of Open Access Journals (Sweden)

    Zhixin Lei

    2017-05-01

    Full Text Available A new, more palatable formulation of 10% enrofloxacin enteric-coated granules was investigated to evaluate the pharmacokinetic effect in plasma, the residue elimination in tissues and the clinical efficacy against Actinobacillus pleuropneumonia (APP and Mycoplasam suis (MS in pigs. In this study, the enrofloxacin concentrations in plasma and tissues were detected using high-performance liquid chromatography with phosphate buffer (pH = 3 and acetonitrile. The pharmacokinetics and elimination of enrofloxacin enteric-coated granules were performed after oral administration at a single dose of 10 mg/kg body weight (bw and 5 mg/kg twice per day for 5 consecutive days, respectively. The in vivo antibacterial efficacy and clinical effectiveness of enrofloxacin enteric-coated granules against APP and MS were assayed at 2.5, 5, 10 mg/kg, compared with tiamulin (8 mg/kg based on establishment of APP and MS infection models. 56 APP strains were selected and tested for in vitro antibacterial activity of enrofloxacin enteric-coated granules. The main parameters of elimination half-life (t1/2β, Tmax, and area under the curve (AUC were 14.99 ± 4.19, 3.99 ± 0.10, and 38.93 ± 1.52 μg h/ml, respectively, revealing that the enrofloxacin concentration remained high and with a sustainable distribution in plasma. Moreover, the analysis on the evaluation of enrofloxacin and ciprofloxacin in muscle, fat, liver and kidney showed that the recovery were more than 84% recovery in accordance with the veterinary drug residue guidelines of United States pharmacopeia, and the withdrawal periods were 4.28, 3.81, 4.84, and 3.51 days, respectively, suggesting that the withdrawal period was 5 d after oral administration of 5 mg/kg twice per day. The optimal dosage of enrofloxacin enteric-coated granules against APP and MS was 5 mg/kg, with over 90% efficacy, which was significantly different (p < 0.05 to the 2.5 mg/kg group, but not to the 10 mg/kg group or the positive

  16. Radiation enteritis

    International Nuclear Information System (INIS)

    Ochsner, S.F.; Head, L.H.

    1973-01-01

    A comprehensive review of radiation enteritis is presented. Experience in clinical radiation therapy has indicated that the small bowel is the segment of the alimentary tract that is most susceptible to radiation damage. (U.S.)

  17. Large-scale structure of the Universe

    International Nuclear Information System (INIS)

    Doroshkevich, A.G.

    1978-01-01

    The problems, discussed at the ''Large-scale Structure of the Universe'' symposium are considered on a popular level. Described are the cell structure of galaxy distribution in the Universe, principles of mathematical galaxy distribution modelling. The images of cell structures, obtained after reprocessing with the computer are given. Discussed are three hypothesis - vortical, entropic, adiabatic, suggesting various processes of galaxy and galaxy clusters origin. A considerable advantage of the adiabatic hypothesis is recognized. The relict radiation, as a method of direct studying the processes taking place in the Universe is considered. The large-scale peculiarities and small-scale fluctuations of the relict radiation temperature enable one to estimate the turbance properties at the pre-galaxy stage. The discussion of problems, pertaining to studying the hot gas, contained in galaxy clusters, the interactions within galaxy clusters and with the inter-galaxy medium, is recognized to be a notable contribution into the development of theoretical and observational cosmology

  18. Emerging large-scale solar heating applications

    International Nuclear Information System (INIS)

    Wong, W.P.; McClung, J.L.

    2009-01-01

    Currently the market for solar heating applications in Canada is dominated by outdoor swimming pool heating, make-up air pre-heating and domestic water heating in homes, commercial and institutional buildings. All of these involve relatively small systems, except for a few air pre-heating systems on very large buildings. Together these applications make up well over 90% of the solar thermal collectors installed in Canada during 2007. These three applications, along with the recent re-emergence of large-scale concentrated solar thermal for generating electricity, also dominate the world markets. This paper examines some emerging markets for large scale solar heating applications, with a focus on the Canadian climate and market. (author)

  19. Emerging large-scale solar heating applications

    Energy Technology Data Exchange (ETDEWEB)

    Wong, W.P.; McClung, J.L. [Science Applications International Corporation (SAIC Canada), Ottawa, Ontario (Canada)

    2009-07-01

    Currently the market for solar heating applications in Canada is dominated by outdoor swimming pool heating, make-up air pre-heating and domestic water heating in homes, commercial and institutional buildings. All of these involve relatively small systems, except for a few air pre-heating systems on very large buildings. Together these applications make up well over 90% of the solar thermal collectors installed in Canada during 2007. These three applications, along with the recent re-emergence of large-scale concentrated solar thermal for generating electricity, also dominate the world markets. This paper examines some emerging markets for large scale solar heating applications, with a focus on the Canadian climate and market. (author)

  20. Challenges for Large Scale Structure Theory

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    I will describe some of the outstanding questions in Cosmology where answers could be provided by observations of the Large Scale Structure of the Universe at late times.I will discuss some of the theoretical challenges which will have to be overcome to extract this information from the observations. I will describe some of the theoretical tools that might be useful to achieve this goal. 

  1. Methods for Large-Scale Nonlinear Optimization.

    Science.gov (United States)

    1980-05-01

    STANFORD, CALIFORNIA 94305 METHODS FOR LARGE-SCALE NONLINEAR OPTIMIZATION by Philip E. Gill, Waiter Murray, I Michael A. Saunden, and Masgaret H. Wright...typical iteration can be partitioned so that where B is an m X m basise matrix. This partition effectively divides the vari- ables into three classes... attention is given to the standard of the coding or the documentation. A much better way of obtaining mathematical software is from a software library

  2. Large scale inhomogeneities and the cosmological principle

    International Nuclear Information System (INIS)

    Lukacs, B.; Meszaros, A.

    1984-12-01

    The compatibility of cosmologic principles and possible large scale inhomogeneities of the Universe is discussed. It seems that the strongest symmetry principle which is still compatible with reasonable inhomogeneities, is a full conformal symmetry in the 3-space defined by the cosmological velocity field, but even in such a case, the standard model is isolated from the inhomogeneous ones when the whole evolution is considered. (author)

  3. Fires in large scale ventilation systems

    International Nuclear Information System (INIS)

    Gregory, W.S.; Martin, R.A.; White, B.W.; Nichols, B.D.; Smith, P.R.; Leslie, I.H.; Fenton, D.L.; Gunaji, M.V.; Blythe, J.P.

    1991-01-01

    This paper summarizes the experience gained simulating fires in large scale ventilation systems patterned after ventilation systems found in nuclear fuel cycle facilities. The series of experiments discussed included: (1) combustion aerosol loading of 0.61x0.61 m HEPA filters with the combustion products of two organic fuels, polystyrene and polymethylemethacrylate; (2) gas dynamic and heat transport through a large scale ventilation system consisting of a 0.61x0.61 m duct 90 m in length, with dampers, HEPA filters, blowers, etc.; (3) gas dynamic and simultaneous transport of heat and solid particulate (consisting of glass beads with a mean aerodynamic diameter of 10μ) through the large scale ventilation system; and (4) the transport of heat and soot, generated by kerosene pool fires, through the large scale ventilation system. The FIRAC computer code, designed to predict fire-induced transients in nuclear fuel cycle facility ventilation systems, was used to predict the results of experiments (2) through (4). In general, the results of the predictions were satisfactory. The code predictions for the gas dynamics, heat transport, and particulate transport and deposition were within 10% of the experimentally measured values. However, the code was less successful in predicting the amount of soot generation from kerosene pool fires, probably due to the fire module of the code being a one-dimensional zone model. The experiments revealed a complicated three-dimensional combustion pattern within the fire room of the ventilation system. Further refinement of the fire module within FIRAC is needed. (orig.)

  4. Large-scale Complex IT Systems

    OpenAIRE

    Sommerville, Ian; Cliff, Dave; Calinescu, Radu; Keen, Justin; Kelly, Tim; Kwiatkowska, Marta; McDermid, John; Paige, Richard

    2011-01-01

    This paper explores the issues around the construction of large-scale complex systems which are built as 'systems of systems' and suggests that there are fundamental reasons, derived from the inherent complexity in these systems, why our current software engineering methods and techniques cannot be scaled up to cope with the engineering challenges of constructing such systems. It then goes on to propose a research and education agenda for software engineering that identifies the major challen...

  5. Large-scale complex IT systems

    OpenAIRE

    Sommerville, Ian; Cliff, Dave; Calinescu, Radu; Keen, Justin; Kelly, Tim; Kwiatkowska, Marta; McDermid, John; Paige, Richard

    2012-01-01

    12 pages, 2 figures This paper explores the issues around the construction of large-scale complex systems which are built as 'systems of systems' and suggests that there are fundamental reasons, derived from the inherent complexity in these systems, why our current software engineering methods and techniques cannot be scaled up to cope with the engineering challenges of constructing such systems. It then goes on to propose a research and education agenda for software engineering that ident...

  6. LAVA: Large scale Automated Vulnerability Addition

    Science.gov (United States)

    2016-05-23

    LAVA: Large-scale Automated Vulnerability Addition Brendan Dolan -Gavitt∗, Patrick Hulin†, Tim Leek†, Fredrich Ulrich†, Ryan Whelan† (Authors listed...released, and thus rapidly become stale. We can expect tools to have been trained to detect bugs that have been released. Given the commercial price tag...low TCN) and dead (low liveness) program data is a powerful one for vulnera- bility injection. The DUAs it identifies are internal program quantities

  7. Large-Scale Transit Signal Priority Implementation

    OpenAIRE

    Lee, Kevin S.; Lozner, Bailey

    2018-01-01

    In 2016, the District Department of Transportation (DDOT) deployed Transit Signal Priority (TSP) at 195 intersections in highly urbanized areas of Washington, DC. In collaboration with a broader regional implementation, and in partnership with the Washington Metropolitan Area Transit Authority (WMATA), DDOT set out to apply a systems engineering–driven process to identify, design, test, and accept a large-scale TSP system. This presentation will highlight project successes and lessons learned.

  8. Economically viable large-scale hydrogen liquefaction

    Science.gov (United States)

    Cardella, U.; Decker, L.; Klein, H.

    2017-02-01

    The liquid hydrogen demand, particularly driven by clean energy applications, will rise in the near future. As industrial large scale liquefiers will play a major role within the hydrogen supply chain, production capacity will have to increase by a multiple of today’s typical sizes. The main goal is to reduce the total cost of ownership for these plants by increasing energy efficiency with innovative and simple process designs, optimized in capital expenditure. New concepts must ensure a manageable plant complexity and flexible operability. In the phase of process development and selection, a dimensioning of key equipment for large scale liquefiers, such as turbines and compressors as well as heat exchangers, must be performed iteratively to ensure technological feasibility and maturity. Further critical aspects related to hydrogen liquefaction, e.g. fluid properties, ortho-para hydrogen conversion, and coldbox configuration, must be analysed in detail. This paper provides an overview on the approach, challenges and preliminary results in the development of efficient as well as economically viable concepts for large-scale hydrogen liquefaction.

  9. The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.

    Directory of Open Access Journals (Sweden)

    Laura M F Kuijpers

    2017-09-01

    Full Text Available Enteric fever remains a major public health problem in low resource settings and antibiotic resistance is increasing. In Asia, an increasing proportion of infections is caused by Salmonella enterica serovar Paratyphi A, which for a long time was assumed to cause a milder clinical syndrome compared to Salmonella enterica serovar Typhi.A retrospective chart review study was conducted of 254 unique cases of blood culture confirmed enteric fever who presented at a referral adult hospital in Phnom Penh, Cambodia between 2008 and 2015. Demographic, clinical and laboratory data were collected from clinical charts and antibiotic susceptibility testing was performed. Whole genome sequence analysis was performed on a subset of 121 isolates.One-hundred-and-ninety unique patients were diagnosed with Salmonella Paratyphi A and 64 with Salmonella Typhi. In the period 2008-2012, Salmonella Paratyphi A comprised 25.5% of 47 enteric fever cases compared to 86.0% of 207 cases during 2013-2015. Presenting symptoms were identical for both serovars but higher median leukocyte counts (6.8 x 109/L vs. 6.3 x 109/L; p = 0.035 and C-reactive protein (CRP values (47.0 mg/L vs. 36 mg/L; p = 0.034 were observed for Salmonella Typhi infections. All but one of the Salmonella Typhi isolates belonged to haplotype H58 associated with multidrug resistance (MDR (i.e. resistance to ampicillin, chloramphenicol and co-trimoxazole.;42.9% actually displayed MDR compared to none of the Salmonella Paratyphi A isolates. Decreased ciprofloxacin susceptibility (DCS was observed in 96.9% (62/64 of Salmonella Typhi isolates versus 11.5% (21/183 of Salmonella Paratyphi A isolates (all but one from 2015. All isolates were susceptible to azithromycin and ceftriaxone.In Phnom Penh, Cambodia, Salmonella Paratyphi A now causes the majority of enteric fever cases and decreased susceptibility against ciprofloxacin is increasing. Overall, Salmonella Typhi was significantly more associated with MDR and

  10. The Software Reliability of Large Scale Integration Circuit and Very Large Scale Integration Circuit

    OpenAIRE

    Artem Ganiyev; Jan Vitasek

    2010-01-01

    This article describes evaluation method of faultless function of large scale integration circuits (LSI) and very large scale integration circuits (VLSI). In the article there is a comparative analysis of factors which determine faultless of integrated circuits, analysis of already existing methods and model of faultless function evaluation of LSI and VLSI. The main part describes a proposed algorithm and program for analysis of fault rate in LSI and VLSI circuits.

  11. RESTRUCTURING OF THE LARGE-SCALE SPRINKLERS

    Directory of Open Access Journals (Sweden)

    Paweł Kozaczyk

    2016-09-01

    Full Text Available One of the best ways for agriculture to become independent from shortages of precipitation is irrigation. In the seventies and eighties of the last century a number of large-scale sprinklers in Wielkopolska was built. At the end of 1970’s in the Poznan province 67 sprinklers with a total area of 6400 ha were installed. The average size of the sprinkler reached 95 ha. In 1989 there were 98 sprinklers, and the area which was armed with them was more than 10 130 ha. The study was conducted on 7 large sprinklers with the area ranging from 230 to 520 hectares in 1986÷1998. After the introduction of the market economy in the early 90’s and ownership changes in agriculture, large-scale sprinklers have gone under a significant or total devastation. Land on the State Farms of the State Agricultural Property Agency has leased or sold and the new owners used the existing sprinklers to a very small extent. This involved a change in crop structure, demand structure and an increase in operating costs. There has also been a threefold increase in electricity prices. Operation of large-scale irrigation encountered all kinds of barriers in practice and limitations of system solutions, supply difficulties, high levels of equipment failure which is not inclined to rational use of available sprinklers. An effect of a vision of the local area was to show the current status of the remaining irrigation infrastructure. The adopted scheme for the restructuring of Polish agriculture was not the best solution, causing massive destruction of assets previously invested in the sprinkler system.

  12. Effect of precipitation on clinic-diagnosed enteric infections in children in Rwanda: an observational study

    Directory of Open Access Journals (Sweden)

    Miles Kirby, PhD

    2018-05-01

    Full Text Available Background: Enteric infections are a major cause of morbidity and mortality in low-income and middle-income countries, particularly among children younger than 5 years. Climate change projections for Rwanda predict increases in average temperature, along with increases in total precipitation and frequency of extreme rainfall events. Previous research in Rwanda has found that extreme rainfall events increase the risk of contaminated drinking water, a substantial contributor to diarrhoea in this setting. Relatively little is known about the effect of precipitation on more severe clinic-diagnosed infections in rural, low-income settings such as Rwanda. In the context of a randomised controlled trial to assess the effect of a national environmental health campaign in Rwanda, we did a substudy to assess the effect of total and extreme rainfall on enteric infections in children younger than 5 years. Methods: For this observational study, we collected data from all government health facilities in Rusizi District, Western Province, for the year 2015. Patient data for children younger than 5 years from 150 study villages were extracted from paper-based registers. Gridded daily precipitation data were downloaded from the Tropical Applications of Meteorology using SATellite and ground based observations (TAMSAT rainfall dataset in addition to local weather station data. We modelled the effect of total rainfall (in mm and occurrence of an extreme rainfall event (95th percentile in the past 2 years on daily health facility visits for enteric symptoms (diarrhoea, gastroenteritis, or vomiting, using Poisson regression with a Newey-West estimator to adjust for serial autocorrelation. We examined total and extreme rainfall within the previous 1, 2, 3, and 4 weeks, controlling for weekend day because we observed a consistent reduction in case counts on weekends. Findings: Data were extracted from 46 facilities, with a study catchment area of approximately 12

  13. Optical interconnect for large-scale systems

    Science.gov (United States)

    Dress, William

    2013-02-01

    This paper presents a switchless, optical interconnect module that serves as a node in a network of identical distribution modules for large-scale systems. Thousands to millions of hosts or endpoints may be interconnected by a network of such modules, avoiding the need for multi-level switches. Several common network topologies are reviewed and their scaling properties assessed. The concept of message-flow routing is discussed in conjunction with the unique properties enabled by the optical distribution module where it is shown how top-down software control (global routing tables, spanning-tree algorithms) may be avoided.

  14. Adaptive visualization for large-scale graph

    International Nuclear Information System (INIS)

    Nakamura, Hiroko; Shinano, Yuji; Ohzahata, Satoshi

    2010-01-01

    We propose an adoptive visualization technique for representing a large-scale hierarchical dataset within limited display space. A hierarchical dataset has nodes and links showing the parent-child relationship between the nodes. These nodes and links are described using graphics primitives. When the number of these primitives is large, it is difficult to recognize the structure of the hierarchical data because many primitives are overlapped within a limited region. To overcome this difficulty, we propose an adaptive visualization technique for hierarchical datasets. The proposed technique selects an appropriate graph style according to the nodal density in each area. (author)

  15. Neutrinos and large-scale structure

    International Nuclear Information System (INIS)

    Eisenstein, Daniel J.

    2015-01-01

    I review the use of cosmological large-scale structure to measure properties of neutrinos and other relic populations of light relativistic particles. With experiments to measure the anisotropies of the cosmic microwave anisotropies and the clustering of matter at low redshift, we now have securely measured a relativistic background with density appropriate to the cosmic neutrino background. Our limits on the mass of the neutrino continue to shrink. Experiments coming in the next decade will greatly improve the available precision on searches for the energy density of novel relativistic backgrounds and the mass of neutrinos

  16. Puzzles of large scale structure and gravitation

    International Nuclear Information System (INIS)

    Sidharth, B.G.

    2006-01-01

    We consider the puzzle of cosmic voids bounded by two-dimensional structures of galactic clusters as also a puzzle pointed out by Weinberg: How can the mass of a typical elementary particle depend on a cosmic parameter like the Hubble constant? An answer to the first puzzle is proposed in terms of 'Scaled' Quantum Mechanical like behaviour which appears at large scales. The second puzzle can be answered by showing that the gravitational mass of an elementary particle has a Machian character (see Ahmed N. Cantorian small worked, Mach's principle and the universal mass network. Chaos, Solitons and Fractals 2004;21(4))

  17. Neutrinos and large-scale structure

    Energy Technology Data Exchange (ETDEWEB)

    Eisenstein, Daniel J. [Daniel J. Eisenstein, Harvard-Smithsonian Center for Astrophysics, 60 Garden St., MS #20, Cambridge, MA 02138 (United States)

    2015-07-15

    I review the use of cosmological large-scale structure to measure properties of neutrinos and other relic populations of light relativistic particles. With experiments to measure the anisotropies of the cosmic microwave anisotropies and the clustering of matter at low redshift, we now have securely measured a relativistic background with density appropriate to the cosmic neutrino background. Our limits on the mass of the neutrino continue to shrink. Experiments coming in the next decade will greatly improve the available precision on searches for the energy density of novel relativistic backgrounds and the mass of neutrinos.

  18. Concepts for Large Scale Hydrogen Production

    OpenAIRE

    Jakobsen, Daniel; Åtland, Vegar

    2016-01-01

    The objective of this thesis is to perform a techno-economic analysis of large-scale, carbon-lean hydrogen production in Norway, in order to evaluate various production methods and estimate a breakeven price level. Norway possesses vast energy resources and the export of oil and gas is vital to the country s economy. The results of this thesis indicate that hydrogen represents a viable, carbon-lean opportunity to utilize these resources, which can prove key in the future of Norwegian energy e...

  19. Stabilization Algorithms for Large-Scale Problems

    DEFF Research Database (Denmark)

    Jensen, Toke Koldborg

    2006-01-01

    The focus of the project is on stabilization of large-scale inverse problems where structured models and iterative algorithms are necessary for computing approximate solutions. For this purpose, we study various iterative Krylov methods and their abilities to produce regularized solutions. Some......-curve. This heuristic is implemented as a part of a larger algorithm which is developed in collaboration with G. Rodriguez and P. C. Hansen. Last, but not least, a large part of the project has, in different ways, revolved around the object-oriented Matlab toolbox MOORe Tools developed by PhD Michael Jacobsen. New...

  20. Large scale phononic metamaterials for seismic isolation

    International Nuclear Information System (INIS)

    Aravantinos-Zafiris, N.; Sigalas, M. M.

    2015-01-01

    In this work, we numerically examine structures that could be characterized as large scale phononic metamaterials. These novel structures could have band gaps in the frequency spectrum of seismic waves when their dimensions are chosen appropriately, thus raising the belief that they could be serious candidates for seismic isolation structures. Different and easy to fabricate structures were examined made from construction materials such as concrete and steel. The well-known finite difference time domain method is used in our calculations in order to calculate the band structures of the proposed metamaterials

  1. Dipolar modulation of Large-Scale Structure

    Science.gov (United States)

    Yoon, Mijin

    For the last two decades, we have seen a drastic development of modern cosmology based on various observations such as the cosmic microwave background (CMB), type Ia supernovae, and baryonic acoustic oscillations (BAO). These observational evidences have led us to a great deal of consensus on the cosmological model so-called LambdaCDM and tight constraints on cosmological parameters consisting the model. On the other hand, the advancement in cosmology relies on the cosmological principle: the universe is isotropic and homogeneous on large scales. Testing these fundamental assumptions is crucial and will soon become possible given the planned observations ahead. Dipolar modulation is the largest angular anisotropy of the sky, which is quantified by its direction and amplitude. We measured a huge dipolar modulation in CMB, which mainly originated from our solar system's motion relative to CMB rest frame. However, we have not yet acquired consistent measurements of dipolar modulations in large-scale structure (LSS), as they require large sky coverage and a number of well-identified objects. In this thesis, we explore measurement of dipolar modulation in number counts of LSS objects as a test of statistical isotropy. This thesis is based on two papers that were published in peer-reviewed journals. In Chapter 2 [Yoon et al., 2014], we measured a dipolar modulation in number counts of WISE matched with 2MASS sources. In Chapter 3 [Yoon & Huterer, 2015], we investigated requirements for detection of kinematic dipole in future surveys.

  2. Internationalization Measures in Large Scale Research Projects

    Science.gov (United States)

    Soeding, Emanuel; Smith, Nancy

    2017-04-01

    Internationalization measures in Large Scale Research Projects Large scale research projects (LSRP) often serve as flagships used by universities or research institutions to demonstrate their performance and capability to stakeholders and other interested parties. As the global competition among universities for the recruitment of the brightest brains has increased, effective internationalization measures have become hot topics for universities and LSRP alike. Nevertheless, most projects and universities are challenged with little experience on how to conduct these measures and make internationalization an cost efficient and useful activity. Furthermore, those undertakings permanently have to be justified with the Project PIs as important, valuable tools to improve the capacity of the project and the research location. There are a variety of measures, suited to support universities in international recruitment. These include e.g. institutional partnerships, research marketing, a welcome culture, support for science mobility and an effective alumni strategy. These activities, although often conducted by different university entities, are interlocked and can be very powerful measures if interfaced in an effective way. On this poster we display a number of internationalization measures for various target groups, identify interfaces between project management, university administration, researchers and international partners to work together, exchange information and improve processes in order to be able to recruit, support and keep the brightest heads to your project.

  3. Large scale integration of photovoltaics in cities

    International Nuclear Information System (INIS)

    Strzalka, Aneta; Alam, Nazmul; Duminil, Eric; Coors, Volker; Eicker, Ursula

    2012-01-01

    Highlights: ► We implement the photovoltaics on a large scale. ► We use three-dimensional modelling for accurate photovoltaic simulations. ► We consider the shadowing effect in the photovoltaic simulation. ► We validate the simulated results using detailed hourly measured data. - Abstract: For a large scale implementation of photovoltaics (PV) in the urban environment, building integration is a major issue. This includes installations on roof or facade surfaces with orientations that are not ideal for maximum energy production. To evaluate the performance of PV systems in urban settings and compare it with the building user’s electricity consumption, three-dimensional geometry modelling was combined with photovoltaic system simulations. As an example, the modern residential district of Scharnhauser Park (SHP) near Stuttgart/Germany was used to calculate the potential of photovoltaic energy and to evaluate the local own consumption of the energy produced. For most buildings of the district only annual electrical consumption data was available and only selected buildings have electronic metering equipment. The available roof area for one of these multi-family case study buildings was used for a detailed hourly simulation of the PV power production, which was then compared to the hourly measured electricity consumption. The results were extrapolated to all buildings of the analyzed area by normalizing them to the annual consumption data. The PV systems can produce 35% of the quarter’s total electricity consumption and half of this generated electricity is directly used within the buildings.

  4. Status: Large-scale subatmospheric cryogenic systems

    International Nuclear Information System (INIS)

    Peterson, T.

    1989-01-01

    In the late 1960's and early 1970's an interest in testing and operating RF cavities at 1.8K motivated the development and construction of four large (300 Watt) 1.8K refrigeration systems. in the past decade, development of successful superconducting RF cavities and interest in obtaining higher magnetic fields with the improved Niobium-Titanium superconductors has once again created interest in large-scale 1.8K refrigeration systems. The L'Air Liquide plant for Tore Supra is a recently commissioned 300 Watt 1.8K system which incorporates new technology, cold compressors, to obtain the low vapor pressure for low temperature cooling. CEBAF proposes to use cold compressors to obtain 5KW at 2.0K. Magnetic refrigerators of 10 Watt capacity or higher at 1.8K are now being developed. The state of the art of large-scale refrigeration in the range under 4K will be reviewed. 28 refs., 4 figs., 7 tabs

  5. Large-scale Intelligent Transporation Systems simulation

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, T.; Canfield, T.; Hannebutte, U.; Levine, D.; Tentner, A.

    1995-06-01

    A prototype computer system has been developed which defines a high-level architecture for a large-scale, comprehensive, scalable simulation of an Intelligent Transportation System (ITS) capable of running on massively parallel computers and distributed (networked) computer systems. The prototype includes the modelling of instrumented ``smart`` vehicles with in-vehicle navigation units capable of optimal route planning and Traffic Management Centers (TMC). The TMC has probe vehicle tracking capabilities (display position and attributes of instrumented vehicles), and can provide 2-way interaction with traffic to provide advisories and link times. Both the in-vehicle navigation module and the TMC feature detailed graphical user interfaces to support human-factors studies. The prototype has been developed on a distributed system of networked UNIX computers but is designed to run on ANL`s IBM SP-X parallel computer system for large scale problems. A novel feature of our design is that vehicles will be represented by autonomus computer processes, each with a behavior model which performs independent route selection and reacts to external traffic events much like real vehicles. With this approach, one will be able to take advantage of emerging massively parallel processor (MPP) systems.

  6. ANTITRUST ISSUES IN THE LARGE-SCALE FOOD DISTRIBUTION SECTOR

    Directory of Open Access Journals (Sweden)

    Enrico Adriano Raffaelli

    2014-12-01

    Full Text Available In light of the slow modernization of the Italian large-scale food distribution sector, of the fragmentation at national level, of the significant roles of the cooperatives at local level and of the alliances between food retail chains, the ICA during the recent years has developed a strong interest in this sector.After having analyzed the peculiarities of the Italian large-scale food distribution sector, this article shows the recent approach taken by the ICA toward the main antitrust issues in this sector.In the analysis of such issues, mainly the contractual relations between the GDO retailers and their suppliers, the introduction of Article 62 of Law no. 27 dated 24th March 2012 is crucial, because, by facilitating and encouraging complaints by the interested parties, it should allow the developing of normal competitive dynamics within the food distribution sector, where companies should be free to enter the market using the tools at their disposal, without undue restrictions.

  7. Enteric fever in Mumbai--clinical profile, sensitivity patterns and response to antimicrobials.

    Science.gov (United States)

    Jog, S; Soman, R; Singhal, T; Rodrigues, C; Mehta, A; Dastur, F D

    2008-04-01

    Enteric fever is endemic in Mumbai and its diagnosis poses several problems. Our main aim was to study the clinical profile, haematological features of culture proven typhoid cases, the antimicrobial susceptibility pattern of the isolates and the time to defervescence with the treatment received. This was a retospective chart review of all cases of culture proven enteric fever carried out at a tertiary care private hospital in Mumbai over the period January 2003 to September 2005. Culture positivity in our study was 52.6%. Sixty one percent of the isolates were Salmonella typhi while 39% were Salmonella paratyphi A. An absolute eosinopenia was seen in 76.9% of the patients. Before being admitted to the hospital, 46.2% received antibiotics. The mean time to defervescence in patients who received prior antibiotics was 4.5 days while that in those who did not receive prior antibiotics was 5.1 days. A high culture positivity despite prior or ongoing antibiotic treatment was seen. Absolute eosinophil count of 0% could be an important marker of typhoid. High prevalence of nalidixic acid resistance, a marker of resistance to fluoroquinolones was observed. Combination treatment was not found to be superior to treatment with a single antibiotic.

  8. Signaling in large-scale neural networks

    DEFF Research Database (Denmark)

    Berg, Rune W; Hounsgaard, Jørn

    2009-01-01

    We examine the recent finding that neurons in spinal motor circuits enter a high conductance state during functional network activity. The underlying concomitant increase in random inhibitory and excitatory synaptic activity leads to stochastic signal processing. The possible advantages of this m......We examine the recent finding that neurons in spinal motor circuits enter a high conductance state during functional network activity. The underlying concomitant increase in random inhibitory and excitatory synaptic activity leads to stochastic signal processing. The possible advantages...... of this metabolically costly organization are analyzed by comparing with synaptically less intense networks driven by the intrinsic response properties of the network neurons....

  9. Radiations: large scale monitoring in Japan

    International Nuclear Information System (INIS)

    Linton, M.; Khalatbari, A.

    2011-01-01

    As the consequences of radioactive leaks on their health are a matter of concern for Japanese people, a large scale epidemiological study has been launched by the Fukushima medical university. It concerns the two millions inhabitants of the Fukushima Prefecture. On the national level and with the support of public funds, medical care and follow-up, as well as systematic controls are foreseen, notably to check the thyroid of 360.000 young people less than 18 year old and of 20.000 pregnant women in the Fukushima Prefecture. Some measurements have already been performed on young children. Despite the sometimes rather low measures, and because they know that some parts of the area are at least as much contaminated as it was the case around Chernobyl, some people are reluctant to go back home

  10. Large-scale digitizer system, analog converters

    International Nuclear Information System (INIS)

    Althaus, R.F.; Lee, K.L.; Kirsten, F.A.; Wagner, L.J.

    1976-10-01

    Analog to digital converter circuits that are based on the sharing of common resources, including those which are critical to the linearity and stability of the individual channels, are described. Simplicity of circuit composition is valued over other more costly approaches. These are intended to be applied in a large-scale processing and digitizing system for use with high-energy physics detectors such as drift-chambers or phototube-scintillator arrays. Signal distribution techniques are of paramount importance in maintaining adequate signal-to-noise ratio. Noise in both amplitude and time-jitter senses is held sufficiently low so that conversions with 10-bit charge resolution and 12-bit time resolution are achieved

  11. Engineering management of large scale systems

    Science.gov (United States)

    Sanders, Serita; Gill, Tepper L.; Paul, Arthur S.

    1989-01-01

    The organization of high technology and engineering problem solving, has given rise to an emerging concept. Reasoning principles for integrating traditional engineering problem solving with system theory, management sciences, behavioral decision theory, and planning and design approaches can be incorporated into a methodological approach to solving problems with a long range perspective. Long range planning has a great potential to improve productivity by using a systematic and organized approach. Thus, efficiency and cost effectiveness are the driving forces in promoting the organization of engineering problems. Aspects of systems engineering that provide an understanding of management of large scale systems are broadly covered here. Due to the focus and application of research, other significant factors (e.g., human behavior, decision making, etc.) are not emphasized but are considered.

  12. Grid sensitivity capability for large scale structures

    Science.gov (United States)

    Nagendra, Gopal K.; Wallerstein, David V.

    1989-01-01

    The considerations and the resultant approach used to implement design sensitivity capability for grids into a large scale, general purpose finite element system (MSC/NASTRAN) are presented. The design variables are grid perturbations with a rather general linking capability. Moreover, shape and sizing variables may be linked together. The design is general enough to facilitate geometric modeling techniques for generating design variable linking schemes in an easy and straightforward manner. Test cases have been run and validated by comparison with the overall finite difference method. The linking of a design sensitivity capability for shape variables in MSC/NASTRAN with an optimizer would give designers a powerful, automated tool to carry out practical optimization design of real life, complicated structures.

  13. Large - scale Rectangular Ruler Automated Verification Device

    Science.gov (United States)

    Chen, Hao; Chang, Luping; Xing, Minjian; Xie, Xie

    2018-03-01

    This paper introduces a large-scale rectangular ruler automated verification device, which consists of photoelectric autocollimator and self-designed mechanical drive car and data automatic acquisition system. The design of mechanical structure part of the device refer to optical axis design, drive part, fixture device and wheel design. The design of control system of the device refer to hardware design and software design, and the hardware mainly uses singlechip system, and the software design is the process of the photoelectric autocollimator and the automatic data acquisition process. This devices can automated achieve vertical measurement data. The reliability of the device is verified by experimental comparison. The conclusion meets the requirement of the right angle test procedure.

  14. Large Scale Landform Mapping Using Lidar DEM

    Directory of Open Access Journals (Sweden)

    Türkay Gökgöz

    2015-08-01

    Full Text Available In this study, LIDAR DEM data was used to obtain a primary landform map in accordance with a well-known methodology. This primary landform map was generalized using the Focal Statistics tool (Majority, considering the minimum area condition in cartographic generalization in order to obtain landform maps at 1:1000 and 1:5000 scales. Both the primary and the generalized landform maps were verified visually with hillshaded DEM and an orthophoto. As a result, these maps provide satisfactory visuals of the landforms. In order to show the effect of generalization, the area of each landform in both the primary and the generalized maps was computed. Consequently, landform maps at large scales could be obtained with the proposed methodology, including generalization using LIDAR DEM.

  15. Constructing sites on a large scale

    DEFF Research Database (Denmark)

    Braae, Ellen Marie; Tietjen, Anne

    2011-01-01

    Since the 1990s, the regional scale has regained importance in urban and landscape design. In parallel, the focus in design tasks has shifted from master plans for urban extension to strategic urban transformation projects. A prominent example of a contemporary spatial development approach...... for setting the design brief in a large scale urban landscape in Norway, the Jaeren region around the city of Stavanger. In this paper, we first outline the methodological challenges and then present and discuss the proposed method based on our teaching experiences. On this basis, we discuss aspects...... is the IBA Emscher Park in the Ruhr area in Germany. Over a 10 years period (1988-1998), more than a 100 local transformation projects contributed to the transformation from an industrial to a post-industrial region. The current paradigm of planning by projects reinforces the role of the design disciplines...

  16. Large scale study of tooth enamel

    International Nuclear Information System (INIS)

    Bodart, F.; Deconninck, G.; Martin, M.T.

    Human tooth enamel contains traces of foreign elements. The presence of these elements is related to the history and the environment of the human body and can be considered as the signature of perturbations which occur during the growth of a tooth. A map of the distribution of these traces on a large scale sample of the population will constitute a reference for further investigations of environmental effects. On hundred eighty samples of teeth were first analyzed using PIXE, backscattering and nuclear reaction techniques. The results were analyzed using statistical methods. Correlations between O, F, Na, P, Ca, Mn, Fe, Cu, Zn, Pb and Sr were observed and cluster analysis was in progress. The techniques described in the present work have been developed in order to establish a method for the exploration of very large samples of the Belgian population. (author)

  17. Large-Scale Astrophysical Visualization on Smartphones

    Science.gov (United States)

    Becciani, U.; Massimino, P.; Costa, A.; Gheller, C.; Grillo, A.; Krokos, M.; Petta, C.

    2011-07-01

    Nowadays digital sky surveys and long-duration, high-resolution numerical simulations using high performance computing and grid systems produce multidimensional astrophysical datasets in the order of several Petabytes. Sharing visualizations of such datasets within communities and collaborating research groups is of paramount importance for disseminating results and advancing astrophysical research. Moreover educational and public outreach programs can benefit greatly from novel ways of presenting these datasets by promoting understanding of complex astrophysical processes, e.g., formation of stars and galaxies. We have previously developed VisIVO Server, a grid-enabled platform for high-performance large-scale astrophysical visualization. This article reviews the latest developments on VisIVO Web, a custom designed web portal wrapped around VisIVO Server, then introduces VisIVO Smartphone, a gateway connecting VisIVO Web and data repositories for mobile astrophysical visualization. We discuss current work and summarize future developments.

  18. Large-scale sequential quadratic programming algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Eldersveld, S.K.

    1992-09-01

    The problem addressed is the general nonlinear programming problem: finding a local minimizer for a nonlinear function subject to a mixture of nonlinear equality and inequality constraints. The methods studied are in the class of sequential quadratic programming (SQP) algorithms, which have previously proved successful for problems of moderate size. Our goal is to devise an SQP algorithm that is applicable to large-scale optimization problems, using sparse data structures and storing less curvature information but maintaining the property of superlinear convergence. The main features are: 1. The use of a quasi-Newton approximation to the reduced Hessian of the Lagrangian function. Only an estimate of the reduced Hessian matrix is required by our algorithm. The impact of not having available the full Hessian approximation is studied and alternative estimates are constructed. 2. The use of a transformation matrix Q. This allows the QP gradient to be computed easily when only the reduced Hessian approximation is maintained. 3. The use of a reduced-gradient form of the basis for the null space of the working set. This choice of basis is more practical than an orthogonal null-space basis for large-scale problems. The continuity condition for this choice is proven. 4. The use of incomplete solutions of quadratic programming subproblems. Certain iterates generated by an active-set method for the QP subproblem are used in place of the QP minimizer to define the search direction for the nonlinear problem. An implementation of the new algorithm has been obtained by modifying the code MINOS. Results and comparisons with MINOS and NPSOL are given for the new algorithm on a set of 92 test problems.

  19. Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence

    Directory of Open Access Journals (Sweden)

    Naess Halvor

    2012-02-01

    Full Text Available Abstract Background A waterborne outbreak of Giardia lamblia gastroenteritis led to a high prevalance of long-lasting fatigue and abdominal symptoms. The aim was to describe the clinical characteristics, disability and employmentloss in a case series of patients with Chronic Fatigue Syndrome (CFS after the infection. Methods Patients who reported persistent fatigue, lowered functional capacity and sickness leave or delayed education after a large community outbreak of giardiasis enteritis in the city of Bergen, Norway were evaluated with the established Centers for Disease Control and Prevention criteria for CFS. Fatigue was self-rated by the Fatigue Severity Scale (FSS. Physical and mental health status and functional impairment was measured by the Medical Outcome Severity Scale-short Form-36 (SF-36. The Hospital Anxiety and Depression Scale (HADS was used to measure co-morbid anxiety and depression. Inability to work or study because of fatigue was determined by sickness absence certified by a doctor. Results A total of 58 (60% out of 96 patients with long-lasting post-infectious fatigue after laboratory confirmed giardiasis were diagnosed with CFS. In all, 1262 patients had laboratory confirmed giardiasis. At the time of referral (mean illness duration 2.7 years 16% reported improvement, 28% reported no change, and 57% reported progressive course with gradual worsening. Mean FSS score was 6.6. A distinctive pattern of impairment was documented with the SF-36. The physical functioning, vitality (energy/fatigue and social functioning were especially reduced. Long-term sickness absence from studies and work was noted in all patients. Conclusion After giardiasis enteritis at least 5% developed clinical characteristics and functional impairment comparable to previously described post-infectious fatigue syndrome.

  20. Detecting differential protein expression in large-scale population proteomics

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Soyoung; Qian, Weijun; Camp, David G.; Smith, Richard D.; Tompkins, Ronald G.; Davis, Ronald W.; Xiao, Wenzhong

    2014-06-17

    Mass spectrometry-based high-throughput quantitative proteomics shows great potential in clinical biomarker studies, identifying and quantifying thousands of proteins in biological samples. However, methods are needed to appropriately handle issues/challenges unique to mass spectrometry data in order to detect as many biomarker proteins as possible. One issue is that different mass spectrometry experiments generate quite different total numbers of quantified peptides, which can result in more missing peptide abundances in an experiment with a smaller total number of quantified peptides. Another issue is that the quantification of peptides is sometimes absent, especially for less abundant peptides and such missing values contain the information about the peptide abundance. Here, we propose a Significance Analysis for Large-scale Proteomics Studies (SALPS) that handles missing peptide intensity values caused by the two mechanisms mentioned above. Our model has a robust performance in both simulated data and proteomics data from a large clinical study. Because varying patients’ sample qualities and deviating instrument performances are not avoidable for clinical studies performed over the course of several years, we believe that our approach will be useful to analyze large-scale clinical proteomics data.

  1. The postoperative clinical outcomes and safety of early enteral nutrition in operated gastric cancer patients.

    Science.gov (United States)

    Li, Bing; Liu, Hong-Yi; Guo, Shao-Hua; Sun, Peng; Gong, Fang-Ming; Jia, Bao-Qing

    2015-01-01

    This study investigated the impact of early enteral nutrition (EEN) on the clinical outcomes of gastric cancer patients after radical gastrectomy. Four hundred gastric cancer patients undergoing radical gastrectomy of any extend with D2 nodal dissection were randomly divided into an experimental and a control group with 200 cases in each group. Patients in the control group received postoperative parenteral nutrition (PN), while patients in the experimental group received postoperative EEN. After treatment, the clinical outcomes, postoperative immune function, and nutritional status of the two groups were evaluated. The postoperative fever time, intestinal function recovery time, anal exhaust time, and the length of hospital stay for patients in the experimental group were significantly shorter than those of the control group. We did not find significant differences in anastomotic leak, postoperative ileus and regurgitation between the two groups. The activities of multiple immune cell types, including CD3⁺, CD4⁺, CD4⁺/CD8⁺, and natural killer (NK) cells, were significantly lower in both groups on postoperative day 1 when compared with the preoperative levels (p0.05). After treatment, levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺, and NK cells in the experimental group patients were 35.6 ± 4.2, 42.2 ± 3.0, 1.7 ± 0.3, and 27.3 ± 5.3%, respectively, on postoperative day 7, which were similar to the preoperative levels. The immune cell levels from the control group patients remained significantly lower when compared with preoperative values; in addition, these values were also significantly lower when compared with the EEN patients (pgastric cancer patients undergoing radical gastrectomy, the clinical outcome, immune function and nutritional status after EEN were significantly improved. These data suggest the widespread use of EEN in clinical practice.

  2. Clinical Onset of Celiac Disease after an Episode of Campylobacter jejuni Enteritis

    Directory of Open Access Journals (Sweden)

    EF Verdu

    2007-01-01

    Full Text Available The present report describes a young woman with no previous gastrointestinal complaints who was initially diagnosed with postinfective irritable bowel syndrome (IBS after a confirmed case of Campylobacter jejuni enteritis. However, because of persistent diarrhea, new-onset bloating and the development of iron and vitamin deficiencies, serological markers for celiac disease (CD were evaluated. A positive tissue transglutaminase immunoglobulin A antibody test and repeat endoscopy with duodenal biopsy showing a Marsh IIIa lesion confirmed the diagnosis of CD. Infectious gastroenteritis is a well-established risk factor for the development of IBS, and there is recent evidence that it could play a role in the initiation and exacerbation of inflammatory bowel disease. The present case suggests that the clinical expression of CD can be unmasked by an acute gastrointestinal infection and supports the hypothesis that environmental factors other than gliadin may play a role in the clinical onset of CD in a genetically susceptible host. The increasing availability of serological testing and upper endoscopy has led to increasingly frequent diagnoses of CD and recognition that it may mimic IBS. The present case findings suggest that CD should be considered in the differential diagnosis of persistent IBS-like symptoms after an episode of infectious gastroenteritis.

  3. High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial.

    Science.gov (United States)

    van Zanten, Arthur R H; Sztark, François; Kaisers, Udo X; Zielmann, Siegfried; Felbinger, Thomas W; Sablotzki, Armin R; De Waele, Jan J; Timsit, Jean-François; Honing, Marina L H; Keh, Didier; Vincent, Jean-Louis; Zazzo, Jean-Fabien; Fijn, Harvey B M; Petit, Laurent; Preiser, Jean-Charles; van Horssen, Peter J; Hofman, Zandrie

    2014-08-06

    Enteral administration of immune-modulating nutrients (eg, glutamine, omega-3 fatty acids, selenium, and antioxidants) has been suggested to reduce infections and improve recovery from critical illness. However, controversy exists on the use of immune-modulating enteral nutrition, reflected by lack of consensus in guidelines. To determine whether high-protein enteral nutrition enriched with immune-modulating nutrients (IMHP) reduces the incidence of infections compared with standard high-protein enteral nutrition (HP) in mechanically ventilated critically ill patients. The MetaPlus study, a randomized, double-blind, multicenter trial, was conducted from February 2010 through April 2012 including a 6-month follow-up period in 14 intensive care units (ICUs) in the Netherlands, Germany, France, and Belgium. A total of 301 adult patients who were expected to be ventilated for more than 72 hours and to require enteral nutrition for more than 72 hours were randomized to the IMHP (n = 152) or HP (n = 149) group and included in an intention-to-treat analysis, performed for the total population as well as predefined medical, surgical, and trauma subpopulations. High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-protein enteral nutrition, initiated within 48 hours of ICU admission and continued during the ICU stay for a maximum of 28 days. The primary outcome measure was incidence of new infections according to the Centers for Disease Control and Prevention (CDC) definitions. Secondary end points included mortality, Sequential Organ Failure Assessment (SOFA) scores, mechanical ventilation duration, ICU and hospital lengths of stay, and subtypes of infections according CDC definitions. There were no statistically significant differences in incidence of new infections between the groups: 53% (95% CI, 44%-61%) in the IMHP group vs 52% (95% CI, 44%-61%) in the HP group (P = .96). No statistically significant differences were

  4. Large-scale stochasticity in Hamiltonian systems

    International Nuclear Information System (INIS)

    Escande, D.F.

    1982-01-01

    Large scale stochasticity (L.S.S.) in Hamiltonian systems is defined on the paradigm Hamiltonian H(v,x,t) =v 2 /2-M cos x-P cos k(x-t) which describes the motion of one particle in two electrostatic waves. A renormalization transformation Tsub(r) is described which acts as a microscope that focusses on a given KAM (Kolmogorov-Arnold-Moser) torus in phase space. Though approximate, Tsub(r) yields the threshold of L.S.S. in H with an error of 5-10%. The universal behaviour of KAM tori is predicted: for instance the scale invariance of KAM tori and the critical exponent of the Lyapunov exponent of Cantori. The Fourier expansion of KAM tori is computed and several conjectures by L. Kadanoff and S. Shenker are proved. Chirikov's standard mapping for stochastic layers is derived in a simpler way and the width of the layers is computed. A simpler renormalization scheme for these layers is defined. A Mathieu equation for describing the stability of a discrete family of cycles is derived. When combined with Tsub(r), it allows to prove the link between KAM tori and nearby cycles, conjectured by J. Greene and, in particular, to compute the mean residue of a torus. The fractal diagrams defined by G. Schmidt are computed. A sketch of a methodology for computing the L.S.S. threshold in any two-degree-of-freedom Hamiltonian system is given. (Auth.)

  5. Large scale molecular simulations of nanotoxicity.

    Science.gov (United States)

    Jimenez-Cruz, Camilo A; Kang, Seung-gu; Zhou, Ruhong

    2014-01-01

    The widespread use of nanomaterials in biomedical applications has been accompanied by an increasing interest in understanding their interactions with tissues, cells, and biomolecules, and in particular, on how they might affect the integrity of cell membranes and proteins. In this mini-review, we present a summary of some of the recent studies on this important subject, especially from the point of view of large scale molecular simulations. The carbon-based nanomaterials and noble metal nanoparticles are the main focus, with additional discussions on quantum dots and other nanoparticles as well. The driving forces for adsorption of fullerenes, carbon nanotubes, and graphene nanosheets onto proteins or cell membranes are found to be mainly hydrophobic interactions and the so-called π-π stacking (between aromatic rings), while for the noble metal nanoparticles the long-range electrostatic interactions play a bigger role. More interestingly, there are also growing evidences showing that nanotoxicity can have implications in de novo design of nanomedicine. For example, the endohedral metallofullerenol Gd@C₈₂(OH)₂₂ is shown to inhibit tumor growth and metastasis by inhibiting enzyme MMP-9, and graphene is illustrated to disrupt bacteria cell membranes by insertion/cutting as well as destructive extraction of lipid molecules. These recent findings have provided a better understanding of nanotoxicity at the molecular level and also suggested therapeutic potential by using the cytotoxicity of nanoparticles against cancer or bacteria cells. © 2014 Wiley Periodicals, Inc.

  6. Large-scale tides in general relativity

    Energy Technology Data Exchange (ETDEWEB)

    Ip, Hiu Yan; Schmidt, Fabian, E-mail: iphys@mpa-garching.mpg.de, E-mail: fabians@mpa-garching.mpg.de [Max-Planck-Institut für Astrophysik, Karl-Schwarzschild-Str. 1, 85741 Garching (Germany)

    2017-02-01

    Density perturbations in cosmology, i.e. spherically symmetric adiabatic perturbations of a Friedmann-Lemaȋtre-Robertson-Walker (FLRW) spacetime, are locally exactly equivalent to a different FLRW solution, as long as their wavelength is much larger than the sound horizon of all fluid components. This fact is known as the 'separate universe' paradigm. However, no such relation is known for anisotropic adiabatic perturbations, which correspond to an FLRW spacetime with large-scale tidal fields. Here, we provide a closed, fully relativistic set of evolutionary equations for the nonlinear evolution of such modes, based on the conformal Fermi (CFC) frame. We show explicitly that the tidal effects are encoded by the Weyl tensor, and are hence entirely different from an anisotropic Bianchi I spacetime, where the anisotropy is sourced by the Ricci tensor. In order to close the system, certain higher derivative terms have to be dropped. We show that this approximation is equivalent to the local tidal approximation of Hui and Bertschinger [1]. We also show that this very simple set of equations matches the exact evolution of the density field at second order, but fails at third and higher order. This provides a useful, easy-to-use framework for computing the fully relativistic growth of structure at second order.

  7. Food appropriation through large scale land acquisitions

    International Nuclear Information System (INIS)

    Cristina Rulli, Maria; D’Odorico, Paolo

    2014-01-01

    The increasing demand for agricultural products and the uncertainty of international food markets has recently drawn the attention of governments and agribusiness firms toward investments in productive agricultural land, mostly in the developing world. The targeted countries are typically located in regions that have remained only marginally utilized because of lack of modern technology. It is expected that in the long run large scale land acquisitions (LSLAs) for commercial farming will bring the technology required to close the existing crops yield gaps. While the extent of the acquired land and the associated appropriation of freshwater resources have been investigated in detail, the amount of food this land can produce and the number of people it could feed still need to be quantified. Here we use a unique dataset of land deals to provide a global quantitative assessment of the rates of crop and food appropriation potentially associated with LSLAs. We show how up to 300–550 million people could be fed by crops grown in the acquired land, should these investments in agriculture improve crop production and close the yield gap. In contrast, about 190–370 million people could be supported by this land without closing of the yield gap. These numbers raise some concern because the food produced in the acquired land is typically exported to other regions, while the target countries exhibit high levels of malnourishment. Conversely, if used for domestic consumption, the crops harvested in the acquired land could ensure food security to the local populations. (letter)

  8. Large Scale EOF Analysis of Climate Data

    Science.gov (United States)

    Prabhat, M.; Gittens, A.; Kashinath, K.; Cavanaugh, N. R.; Mahoney, M.

    2016-12-01

    We present a distributed approach towards extracting EOFs from 3D climate data. We implement the method in Apache Spark, and process multi-TB sized datasets on O(1000-10,000) cores. We apply this method to latitude-weighted ocean temperature data from CSFR, a 2.2 terabyte-sized data set comprising ocean and subsurface reanalysis measurements collected at 41 levels in the ocean, at 6 hour intervals over 31 years. We extract the first 100 EOFs of this full data set and compare to the EOFs computed simply on the surface temperature field. Our analyses provide evidence of Kelvin and Rossy waves and components of large-scale modes of oscillation including the ENSO and PDO that are not visible in the usual SST EOFs. Further, they provide information on the the most influential parts of the ocean, such as the thermocline, that exist below the surface. Work is ongoing to understand the factors determining the depth-varying spatial patterns observed in the EOFs. We will experiment with weighting schemes to appropriately account for the differing depths of the observations. We also plan to apply the same distributed approach to analysis of analysis of 3D atmospheric climatic data sets, including multiple variables. Because the atmosphere changes on a quicker time-scale than the ocean, we expect that the results will demonstrate an even greater advantage to computing 3D EOFs in lieu of 2D EOFs.

  9. Mirror dark matter and large scale structure

    International Nuclear Information System (INIS)

    Ignatiev, A.Yu.; Volkas, R.R.

    2003-01-01

    Mirror matter is a dark matter candidate. In this paper, we reexamine the linear regime of density perturbation growth in a universe containing mirror dark matter. Taking adiabatic scale-invariant perturbations as the input, we confirm that the resulting processed power spectrum is richer than for the more familiar cases of cold, warm and hot dark matter. The new features include a maximum at a certain scale λ max , collisional damping below a smaller characteristic scale λ S ' , with oscillatory perturbations between the two. These scales are functions of the fundamental parameters of the theory. In particular, they decrease for decreasing x, the ratio of the mirror plasma temperature to that of the ordinary. For x∼0.2, the scale λ max becomes galactic. Mirror dark matter therefore leads to bottom-up large scale structure formation, similar to conventional cold dark matter, for x(less-or-similar sign)0.2. Indeed, the smaller the value of x, the closer mirror dark matter resembles standard cold dark matter during the linear regime. The differences pertain to scales smaller than λ S ' in the linear regime, and generally in the nonlinear regime because mirror dark matter is chemically complex and to some extent dissipative. Lyman-α forest data and the early reionization epoch established by WMAP may hold the key to distinguishing mirror dark matter from WIMP-style cold dark matter

  10. Sensitivity technologies for large scale simulation

    International Nuclear Information System (INIS)

    Collis, Samuel Scott; Bartlett, Roscoe Ainsworth; Smith, Thomas Michael; Heinkenschloss, Matthias; Wilcox, Lucas C.; Hill, Judith C.; Ghattas, Omar; Berggren, Martin Olof; Akcelik, Volkan; Ober, Curtis Curry; van Bloemen Waanders, Bart Gustaaf; Keiter, Eric Richard

    2005-01-01

    Sensitivity analysis is critically important to numerous analysis algorithms, including large scale optimization, uncertainty quantification,reduced order modeling, and error estimation. Our research focused on developing tools, algorithms and standard interfaces to facilitate the implementation of sensitivity type analysis into existing code and equally important, the work was focused on ways to increase the visibility of sensitivity analysis. We attempt to accomplish the first objective through the development of hybrid automatic differentiation tools, standard linear algebra interfaces for numerical algorithms, time domain decomposition algorithms and two level Newton methods. We attempt to accomplish the second goal by presenting the results of several case studies in which direct sensitivities and adjoint methods have been effectively applied, in addition to an investigation of h-p adaptivity using adjoint based a posteriori error estimation. A mathematical overview is provided of direct sensitivities and adjoint methods for both steady state and transient simulations. Two case studies are presented to demonstrate the utility of these methods. A direct sensitivity method is implemented to solve a source inversion problem for steady state internal flows subject to convection diffusion. Real time performance is achieved using novel decomposition into offline and online calculations. Adjoint methods are used to reconstruct initial conditions of a contamination event in an external flow. We demonstrate an adjoint based transient solution. In addition, we investigated time domain decomposition algorithms in an attempt to improve the efficiency of transient simulations. Because derivative calculations are at the root of sensitivity calculations, we have developed hybrid automatic differentiation methods and implemented this approach for shape optimization for gas dynamics using the Euler equations. The hybrid automatic differentiation method was applied to a first

  11. GPU-based large-scale visualization

    KAUST Repository

    Hadwiger, Markus

    2013-11-19

    Recent advances in image and volume acquisition as well as computational advances in simulation have led to an explosion of the amount of data that must be visualized and analyzed. Modern techniques combine the parallel processing power of GPUs with out-of-core methods and data streaming to enable the interactive visualization of giga- and terabytes of image and volume data. A major enabler for interactivity is making both the computational and the visualization effort proportional to the amount of data that is actually visible on screen, decoupling it from the full data size. This leads to powerful display-aware multi-resolution techniques that enable the visualization of data of almost arbitrary size. The course consists of two major parts: An introductory part that progresses from fundamentals to modern techniques, and a more advanced part that discusses details of ray-guided volume rendering, novel data structures for display-aware visualization and processing, and the remote visualization of large online data collections. You will learn how to develop efficient GPU data structures and large-scale visualizations, implement out-of-core strategies and concepts such as virtual texturing that have only been employed recently, as well as how to use modern multi-resolution representations. These approaches reduce the GPU memory requirements of extremely large data to a working set size that fits into current GPUs. You will learn how to perform ray-casting of volume data of almost arbitrary size and how to render and process gigapixel images using scalable, display-aware techniques. We will describe custom virtual texturing architectures as well as recent hardware developments in this area. We will also describe client/server systems for distributed visualization, on-demand data processing and streaming, and remote visualization. We will describe implementations using OpenGL as well as CUDA, exploiting parallelism on GPUs combined with additional asynchronous

  12. Attitudes towards industry capitation payments for entering patients into clinical trials

    International Nuclear Information System (INIS)

    Shimm, David S.

    1997-01-01

    PURPOSE: Pharmaceutical companies commonly pay a clinical investigator (CI) for entering patients into a clinical trial. These payments average $3500-$5000, and can be as high as $50,000 per patient, and are rarely disclosed to the clinical research subject (CRS). Capitation payments exceeding direct and indirect expenses present a conflict of interest by posing a temptation for CIs to ignore their fiduciary duty to patients. Since CIs commonly accept such payments, either they do not see, they ignore, or they otherwise manage the conflict of interest posed by accepting this money. This study surveys attitudes towards this practice among students and staff at a university medical center. MATERIALS and METHODS: The survey examined factors which might affect a CI's decision to enroll CRSs into a clinical trial, and attitudes towards financial arrangements between the CI and a study sponsor. Two hundred twenty nine surveys were sent to 75 medical students, 80 housestaff, and 74 attending staff, chosen randomly from personnel rosters. Questionnaires were returned anonymously to conceal the identity of the responder. RESULTS: Eighteen medical students (24%), 13 housestaff (16%), and 24 attending staff (32%) returned questionnaires (overall response rate 24%). Responding MDs represented 13 departments and included 13 primary care MDs. Nineteen (79%) attending staff and 7 (46%) housestaff had conducted clinical research. Responders cited the purpose of the study, potential benefit to the CRS, potential benefit to others, and risk to the CRS as the most important factors that would affect their decision to enter a CRS into a study. Eighteen (75%) attending staff, 12 (92%) housestaff, and 14 (78%) students favored telling CRSs the source of a study's funding. Twenty one (88%) attending staff, all housestaff, and 16 (89%) students favored telling CRSs whether the CI owned stock in the sponsoring company. Sixteen (67%) attendings, all housestaff, and 14 (78%) students favored

  13. Large Scale Self-Organizing Information Distribution System

    National Research Council Canada - National Science Library

    Low, Steven

    2005-01-01

    This project investigates issues in "large-scale" networks. Here "large-scale" refers to networks with large number of high capacity nodes and transmission links, and shared by a large number of users...

  14. Distributed large-scale dimensional metrology new insights

    CERN Document Server

    Franceschini, Fiorenzo; Maisano, Domenico

    2011-01-01

    Focuses on the latest insights into and challenges of distributed large scale dimensional metrology Enables practitioners to study distributed large scale dimensional metrology independently Includes specific examples of the development of new system prototypes

  15. Probes of large-scale structure in the Universe

    International Nuclear Information System (INIS)

    Suto, Yasushi; Gorski, K.; Juszkiewicz, R.; Silk, J.

    1988-01-01

    Recent progress in observational techniques has made it possible to confront quantitatively various models for the large-scale structure of the Universe with detailed observational data. We develop a general formalism to show that the gravitational instability theory for the origin of large-scale structure is now capable of critically confronting observational results on cosmic microwave background radiation angular anisotropies, large-scale bulk motions and large-scale clumpiness in the galaxy counts. (author)

  16. Large scale dynamics of protoplanetary discs

    Science.gov (United States)

    Béthune, William

    2017-08-01

    Planets form in the gaseous and dusty disks orbiting young stars. These protoplanetary disks are dispersed in a few million years, being accreted onto the central star or evaporated into the interstellar medium. To explain the observed accretion rates, it is commonly assumed that matter is transported through the disk by turbulence, although the mechanism sustaining turbulence is uncertain. On the other side, irradiation by the central star could heat up the disk surface and trigger a photoevaporative wind, but thermal effects cannot account for the observed acceleration and collimation of the wind into a narrow jet perpendicular to the disk plane. Both issues can be solved if the disk is sensitive to magnetic fields. Weak fields lead to the magnetorotational instability, whose outcome is a state of sustained turbulence. Strong fields can slow down the disk, causing it to accrete while launching a collimated wind. However, the coupling between the disk and the neutral gas is done via electric charges, each of which is outnumbered by several billion neutral molecules. The imperfect coupling between the magnetic field and the neutral gas is described in terms of "non-ideal" effects, introducing new dynamical behaviors. This thesis is devoted to the transport processes happening inside weakly ionized and weakly magnetized accretion disks; the role of microphysical effects on the large-scale dynamics of the disk is of primary importance. As a first step, I exclude the wind and examine the impact of non-ideal effects on the turbulent properties near the disk midplane. I show that the flow can spontaneously organize itself if the ionization fraction is low enough; in this case, accretion is halted and the disk exhibits axisymmetric structures, with possible consequences on planetary formation. As a second step, I study the launching of disk winds via a global model of stratified disk embedded in a warm atmosphere. This model is the first to compute non-ideal effects from

  17. Large-Scale Spacecraft Fire Safety Tests

    Science.gov (United States)

    Urban, David; Ruff, Gary A.; Ferkul, Paul V.; Olson, Sandra; Fernandez-Pello, A. Carlos; T'ien, James S.; Torero, Jose L.; Cowlard, Adam J.; Rouvreau, Sebastien; Minster, Olivier; hide

    2014-01-01

    An international collaborative program is underway to address open issues in spacecraft fire safety. Because of limited access to long-term low-gravity conditions and the small volume generally allotted for these experiments, there have been relatively few experiments that directly study spacecraft fire safety under low-gravity conditions. Furthermore, none of these experiments have studied sample sizes and environment conditions typical of those expected in a spacecraft fire. The major constraint has been the size of the sample, with prior experiments limited to samples of the order of 10 cm in length and width or smaller. This lack of experimental data forces spacecraft designers to base their designs and safety precautions on 1-g understanding of flame spread, fire detection, and suppression. However, low-gravity combustion research has demonstrated substantial differences in flame behavior in low-gravity. This, combined with the differences caused by the confined spacecraft environment, necessitates practical scale spacecraft fire safety research to mitigate risks for future space missions. To address this issue, a large-scale spacecraft fire experiment is under development by NASA and an international team of investigators. This poster presents the objectives, status, and concept of this collaborative international project (Saffire). The project plan is to conduct fire safety experiments on three sequential flights of an unmanned ISS re-supply spacecraft (the Orbital Cygnus vehicle) after they have completed their delivery of cargo to the ISS and have begun their return journeys to earth. On two flights (Saffire-1 and Saffire-3), the experiment will consist of a flame spread test involving a meter-scale sample ignited in the pressurized volume of the spacecraft and allowed to burn to completion while measurements are made. On one of the flights (Saffire-2), 9 smaller (5 x 30 cm) samples will be tested to evaluate NASAs material flammability screening tests

  18. Large-scale fuel cycle centres

    International Nuclear Information System (INIS)

    Smiley, S.H.; Black, K.M.

    1977-01-01

    The US Nuclear Regulatory Commission (NRC) has considered the nuclear energy centre concept for fuel cycle plants in the Nuclear Energy Centre Site Survey 1975 (NECSS-75) Rep. No. NUREG-0001, an important study mandated by the US Congress in the Energy Reorganization Act of 1974 which created the NRC. For this study, the NRC defined fuel cycle centres as consisting of fuel reprocessing and mixed-oxide fuel fabrication plants, and optional high-level waste and transuranic waste management facilities. A range of fuel cycle centre sizes corresponded to the fuel throughput of power plants with a total capacity of 50,000-300,000MW(e). The types of fuel cycle facilities located at the fuel cycle centre permit the assessment of the role of fuel cycle centres in enhancing the safeguard of strategic special nuclear materials - plutonium and mixed oxides. Siting fuel cycle centres presents a smaller problem than siting reactors. A single reprocessing plant of the scale projected for use in the USA (1500-2000t/a) can reprocess fuel from reactors producing 50,000-65,000MW(e). Only two or three fuel cycle centres of the upper limit size considered in the NECSS-75 would be required in the USA by the year 2000. The NECSS-75 fuel cycle centre evaluation showed that large-scale fuel cycle centres present no real technical siting difficulties from a radiological effluent and safety standpoint. Some construction economies may be achievable with fuel cycle centres, which offer opportunities to improve waste-management systems. Combined centres consisting of reactors and fuel reprocessing and mixed-oxide fuel fabrication plants were also studied in the NECSS. Such centres can eliminate shipment not only of Pu but also mixed-oxide fuel. Increased fuel cycle costs result from implementation of combined centres unless the fuel reprocessing plants are commercial-sized. Development of Pu-burning reactors could reduce any economic penalties of combined centres. The need for effective fissile

  19. Large scale injection test (LASGIT) modelling

    International Nuclear Information System (INIS)

    Arnedo, D.; Olivella, S.; Alonso, E.E.

    2010-01-01

    Document available in extended abstract form only. With the objective of understanding the gas flow processes through clay barriers in schemes of radioactive waste disposal, the Lasgit in situ experiment was planned and is currently in progress. The modelling of the experiment will permit to better understand of the responses, to confirm hypothesis of mechanisms and processes and to learn in order to design future experiments. The experiment and modelling activities are included in the project FORGE (FP7). The in situ large scale injection test Lasgit is currently being performed at the Aespoe Hard Rock Laboratory by SKB and BGS. An schematic layout of the test is shown. The deposition hole follows the KBS3 scheme. A copper canister is installed in the axe of the deposition hole, surrounded by blocks of highly compacted MX-80 bentonite. A concrete plug is placed at the top of the buffer. A metallic lid anchored to the surrounding host rock is included in order to prevent vertical movements of the whole system during gas injection stages (high gas injection pressures are expected to be reached). Hydration of the buffer material is achieved by injecting water through filter mats, two placed at the rock walls and two at the interfaces between bentonite blocks. Water is also injected through the 12 canister filters. Gas injection stages are performed injecting gas to some of the canister injection filters. Since the water pressure and the stresses (swelling pressure development) will be high during gas injection, it is necessary to inject at high gas pressures. This implies mechanical couplings as gas penetrates after the gas entry pressure is achieved and may produce deformations which in turn lead to permeability increments. A 3D hydro-mechanical numerical model of the test using CODE-BRIGHT is presented. The domain considered for the modelling is shown. The materials considered in the simulation are the MX-80 bentonite blocks (cylinders and rings), the concrete plug

  20. Large-scale fuel cycle centers

    International Nuclear Information System (INIS)

    Smiley, S.H.; Black, K.M.

    1977-01-01

    The United States Nuclear Regulatory Commission (NRC) has considered the nuclear energy center concept for fuel cycle plants in the Nuclear Energy Center Site Survey - 1975 (NECSS-75) -- an important study mandated by the U.S. Congress in the Energy Reorganization Act of 1974 which created the NRC. For the study, NRC defined fuel cycle centers to consist of fuel reprocessing and mixed oxide fuel fabrication plants, and optional high-level waste and transuranic waste management facilities. A range of fuel cycle center sizes corresponded to the fuel throughput of power plants with a total capacity of 50,000 - 300,000 MWe. The types of fuel cycle facilities located at the fuel cycle center permit the assessment of the role of fuel cycle centers in enhancing safeguarding of strategic special nuclear materials -- plutonium and mixed oxides. Siting of fuel cycle centers presents a considerably smaller problem than the siting of reactors. A single reprocessing plant of the scale projected for use in the United States (1500-2000 MT/yr) can reprocess the fuel from reactors producing 50,000-65,000 MWe. Only two or three fuel cycle centers of the upper limit size considered in the NECSS-75 would be required in the United States by the year 2000 . The NECSS-75 fuel cycle center evaluations showed that large scale fuel cycle centers present no real technical difficulties in siting from a radiological effluent and safety standpoint. Some construction economies may be attainable with fuel cycle centers; such centers offer opportunities for improved waste management systems. Combined centers consisting of reactors and fuel reprocessing and mixed oxide fuel fabrication plants were also studied in the NECSS. Such centers can eliminate not only shipment of plutonium, but also mixed oxide fuel. Increased fuel cycle costs result from implementation of combined centers unless the fuel reprocessing plants are commercial-sized. Development of plutonium-burning reactors could reduce any

  1. Large-scale assembly of colloidal particles

    Science.gov (United States)

    Yang, Hongta

    This study reports a simple, roll-to-roll compatible coating technology for producing three-dimensional highly ordered colloidal crystal-polymer composites, colloidal crystals, and macroporous polymer membranes. A vertically beveled doctor blade is utilized to shear align silica microsphere-monomer suspensions to form large-area composites in a single step. The polymer matrix and the silica microspheres can be selectively removed to create colloidal crystals and self-standing macroporous polymer membranes. The thickness of the shear-aligned crystal is correlated with the viscosity of the colloidal suspension and the coating speed, and the correlations can be qualitatively explained by adapting the mechanisms developed for conventional doctor blade coating. Five important research topics related to the application of large-scale three-dimensional highly ordered macroporous films by doctor blade coating are covered in this study. The first topic describes the invention in large area and low cost color reflective displays. This invention is inspired by the heat pipe technology. The self-standing macroporous polymer films exhibit brilliant colors which originate from the Bragg diffractive of visible light form the three-dimensional highly ordered air cavities. The colors can be easily changed by tuning the size of the air cavities to cover the whole visible spectrum. When the air cavities are filled with a solvent which has the same refractive index as that of the polymer, the macroporous polymer films become completely transparent due to the index matching. When the solvent trapped in the cavities is evaporated by in-situ heating, the sample color changes back to brilliant color. This process is highly reversible and reproducible for thousands of cycles. The second topic reports the achievement of rapid and reversible vapor detection by using 3-D macroporous photonic crystals. Capillary condensation of a condensable vapor in the interconnected macropores leads to the

  2. A large-scale study of misophonia

    NARCIS (Netherlands)

    Rouw, R.; Erfanian, M.

    2018-01-01

    Objective We aim to elucidate misophonia, a condition in which particular sounds elicit disproportionally strong aversive reactions. Method A large online study extensively surveyed personal, developmental, and clinical characteristics of over 300 misophonics. Results Most participants indicated

  3. Double-Blind Randomized Clinical Trial: Gluten versus Placebo Rechallenge in Patients with Lymphocytic Enteritis and Suspected Celiac Disease.

    Directory of Open Access Journals (Sweden)

    Mercè Rosinach

    Full Text Available The role of gluten as a trigger of symptoms in non-coeliac gluten sensitivity has been questioned.To demonstrate that gluten is the trigger of symptoms in a subgroup of patients fulfilling the diagnostic criteria for non-coeliac gluten sensitivity (NCGS, which presented with lymphocytic enteritis, positive celiac genetics and negative celiac serology.Double-blind randomized clinical trial of gluten vs placebo rechallenge.>18 years of age, HLA-DQ2/8+, negative coeliac serology and gluten-dependent lymphocytic enteritis, and GI symptoms, with clinical and histological remission at inclusion. Eighteen patients were randomised: 11 gluten (20 g/day and 7 placebo. Clinical symptoms, quality of life (GIQLI, and presence of gamma/delta+ cells and transglutaminase deposits were evaluated.91% of patients had clinical relapse during gluten challenge versus 28.5% after placebo (p = 0.01. Clinical scores and GIQLI worsened after gluten but not after placebo (p<0.01. The presence of coeliac tissue markers at baseline biopsy on a gluten-free diet allowed classifying 9 out of the 18 (50% patients as having probable 'coeliac lite' disease.This proof-of-concept study indicates that gluten is the trigger of symptoms in a subgroup of patients fulfilling the diagnostic criteria for NCGS. They were characterized by positive celiac genetics, lymphocytic enteritis, and clinical and histological remission after a gluten-free diet.ClinicalTrials.gov NCT02472704.

  4. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics.

    Science.gov (United States)

    Tonini, M; Cipollina, L; Poluzzi, E; Crema, F; Corazza, G R; De Ponti, F

    2004-02-15

    Antidopaminergic gastrointestinal prokinetics (bromopride, clebopride, domperidone, levosulpiride and metoclopramide) have been exploited clinically for the management of motor disorders of the upper gastrointestinal tract, including functional dyspepsia, gastric stasis of various origins and emesis. The prokinetic effect of these drugs is mediated through the blockade of enteric (neuronal and muscular) inhibitory D2 receptors. The pharmacological profiles of the marketed compounds differ in terms of their molecular structure, affinity at D2 receptors, ability to interact with other receptor systems [5-hydroxytryptamine-3 (5-HT3) and 5-HT4 receptors for metoclopramide; 5-HT4 receptors for levosulpiride) and ability to permeate the blood-brain barrier (compared with the other compounds, domperidone does not easily cross the barrier). It has been suggested that the serotonergic (5-HT4) component of some antidopaminergic prokinetics may enhance their therapeutic efficacy in gastrointestinal disorders, such as functional dyspepsia and diabetic gastroparesis. The antagonism of central D2 receptors may lead to both therapeutic (e.g. anti-emetic effect due to D2 receptor blockade in the area postrema) and adverse (including hyperprolactinaemia and extrapyramidal dystonic reactions) effects. As the pituitary (as well as the area postrema) is outside the blood-brain barrier, hyperprolactinaemia is a side-effect occurring with all antidopaminergic prokinetics, although to different extents. Extrapyramidal reactions are most commonly observed with compounds crossing the blood-brain barrier, although with some differences amongst the various agents. Prokinetics with a high dissociation constant compared with that of dopamine at the D2 receptor (i.e. compounds that bind loosely to D2 receptors in the nigrostriatal pathway) elicit fewer extrapyramidal signs and symptoms. A knowledge of central and peripheral D2 receptor pharmacology can help the clinician to choose between the

  5. Biopolitics problems of large-scale hydraulic engineering construction

    International Nuclear Information System (INIS)

    Romanenko, V.D.

    1997-01-01

    The XX century which will enter in a history as a century of large-scale hydraulic engineering constructions come to the finish. Only on the European continent 517 large reservoirs (more than 1000 million km 3 of water were detained, had been constructed for a period from 1901 till 1985. In the Danube basin a plenty for reservoirs of power stations, navigations, navigating sluices and other hydraulic engineering structures are constructed. Among them more than 40 especially large objects are located along the main bed of the river. A number of hydro-complexes such as Dnieper-Danube and Gabcikovo, Danube-Oder-Labe (project), Danube-Tissa, Danube-Adriatic Sea (project), Danube-Aegean Sea, Danube-Black Sea ones, are entered into operation or are in a stage of designing. Hydraulic engineering construction was especially heavily conducted in Ukraine. On its territory some large reservoirs on Dnieper and Yuzhny Bug were constructed, which have heavily changed the hydrological regime of the rivers. Summarised the results of river systems regulating in Ukraine one can be noted that more than 27 thousand ponds (3 km 3 per year), 1098 reservoirs of total volume 55 km 3 , 11 large channels of total length more than 2000 km and with productivity of 1000 m 2 /s have been created in Ukraine. Hydraulic engineering construction played an important role in development of the industry and agriculture, water-supply of the cities and settlements, in environmental effects, and maintenance of safe navigation in Danube, Dnieper and other rivers. In next part of the paper, the environmental changes after construction of the Karakum Channel on the Aral Sea in the Middle Asia are discussed

  6. Low Triiodothyronine Syndrome in Patients With Radiation Enteritis: Risk Factors and Clinical Outcomes an Observational Study.

    Science.gov (United States)

    Fan, Shengxian; Ni, Xiaodong; Wang, Jian; Zhang, Yongliang; Tao, Shen; Chen, Mimi; Li, Yousheng; Li, Jieshou

    2016-02-01

    The implications of low triiodothyronine syndrome (LT3S) in patients with radiation enteritis (RE) have not been properly investigated. As such, we conducted this cohort study to investigate the association between LT3S and RE, to explore the etiology of LT3S in RE, to evaluate the clinical features and clinical outcomes of LT3S patients, and to inspect the correlation of clinical variables and LT3S in RE.This prospective study included 39 RE patients. Medical records and various laboratory parameters (including thyroidal, tumorous, nutritional, and radiotherapy variables) were collected in all participants.Our results showed that the incidence of LT3S was 84.6% in patients with RE. Total protein (71.7 ± 5.7 vs 63.2 ± 9.6 g/L, P = 0.04) and albumin (ALB, 46.0 ± 4.6 vs 38.7 ± 5.3 g/L, P = 0.01) were significantly lower in LT3S group compared with those in euthyroid group. Standard thyroid-stimulating hormone index (-0.89 ± 2.11 vs -2.39 ± 1.33, P = 0.03) and sum activity of deiodinases (19.74 ± 4.19 vs 12.55 ± 4.32 nmol/L, P = 0.01) were significantly lower in LT3S group. Patients with LT3S suffered longer duration of hospitalization (48.25 ± 23.29 days in LT3S vs 26.75 ± 10.56 days in euthyroid, P = 0.036). Low serum ALB (β = 0.694, 95% CI = 0.007-0.190, P = 0.037) was the only significant predictor of LT3S.LT3S was common in RE patients. A hypodeiodination condition and a potential pituitary-thyrotroph dysfunction might play a role in the pathophysiology of LT3S in RE. Worse nutritional status and clinical outcomes were confirmed in RE patients with LT3S. Furthermore, total protein and ALB were observed as protective and differentiating parameters of LT3S in RE. In summary, this was the 1st investigation to evaluate the clinical correlation between RE and LT3S, investigate the prevalence of LT3S in RE, and explore the pathogenesis of LT3S, despite the limitation of a

  7. Clinical and protein metabolic efficacy of glutamine granules-supplemented enteral nutrition in severely burned patients.

    Science.gov (United States)

    Peng, Xi; Yan, Hong; You, Zhongyi; Wang, Pei; Wang, Shiliang

    2005-05-01

    As an abundant amino acid in the human body, glutamine has many important metabolic roles that may protect or promote tissue integrity and enhance the immune system. A relative deficiency of glutamine in such patients could compromise recovery and result in prolonged illness and an increase in late mortality. The purpose of this clinical study is to observe the effects of enteral supplement with glutamine granules on protein metabolism in severely burned patients. Forty-eight severe burn patients (total burn surface area 30-75%, full thickness burn area 20-58%) who met the requirements of the protocol joined this double-blind randomized controlled clinical trial. Patients were randomly divided into two groups: burn control group (B group, 23 patients) and glutamine treated group (Gln group, 25 patients). There was isonitrogenous and isocaloric intake in both groups, glutamine and B group patents were supplemented with glutamine granules or placebo (glycine) at 0.5 g/kg per day for 14 days with oral feeding or tube feeding, respectively. The level of plasma glutamine, plasma protein content, urine nitrogen and urine 3-methylhistidine (3-MTH) excretion were determined, wound healing rate of the burned area and hospital stay were recorded. The results showed that there were significant reductions in plasma glutamine level and abnormal protein metabolism. After supplement with glutamine granules for 14 days, the plasma glutamine concentration was significantly higher than that in B group (607.86+/-147.25 micromol/L versus 447.63+/-132.38 micromol/L, P0.05). On the other hand, the amount of urine nitrogen and 3-MTH excreted in Gln group were significantly lower than that in B group. In addition, wound healing was faster and hospital stay days were shorter in Gln group than B group (46.59+/-12.98 days versus 55.68+/-17.36 days, P<0.05). These indicated that supplement glutamine granules with oral feeding or tube feeding could abate the degree of glutamine depletion

  8. A Large-Scale Study of Misophonia.

    Science.gov (United States)

    Rouw, Romke; Erfanian, Mercede

    2018-03-01

    We aim to elucidate misophonia, a condition in which particular sounds elicit disproportionally strong aversive reactions. A large online study extensively surveyed personal, developmental, and clinical characteristics of over 300 misophonics. Most participants indicated that their symptoms started in childhood or early teenage years. Severity of misophonic responses increases over time. One third of participants reported having family members with similar symptoms. Half of our participants reported no comorbid clinical conditions, and the other half reported a variety of conditions. Only posttraumatic stress disorder (PTSD) was related to the severity of the misophonic symptoms. Remarkably, half of the participants reported experiencing euphoric, relaxing, and tingling sensations with particular sounds or sights, a relatively unfamiliar phenomenon called autonomous sensory meridian response (ASMR). It is unlikely that another "real" underlying clinical, psychiatric, or psychological disorder can explain away the misophonia. The possible relationship with PTSD and ASMR warrants further investigation. © 2017 Wiley Periodicals, Inc.

  9. Thermal power generation projects ``Large Scale Solar Heating``; EU-Thermie-Projekte ``Large Scale Solar Heating``

    Energy Technology Data Exchange (ETDEWEB)

    Kuebler, R.; Fisch, M.N. [Steinbeis-Transferzentrum Energie-, Gebaeude- und Solartechnik, Stuttgart (Germany)

    1998-12-31

    The aim of this project is the preparation of the ``Large-Scale Solar Heating`` programme for an Europe-wide development of subject technology. The following demonstration programme was judged well by the experts but was not immediately (1996) accepted for financial subsidies. In November 1997 the EU-commission provided 1,5 million ECU which allowed the realisation of an updated project proposal. By mid 1997 a small project was approved, that had been requested under the lead of Chalmes Industriteteknik (CIT) in Sweden and is mainly carried out for the transfer of technology. (orig.) [Deutsch] Ziel dieses Vorhabens ist die Vorbereitung eines Schwerpunktprogramms `Large Scale Solar Heating`, mit dem die Technologie europaweit weiterentwickelt werden sollte. Das daraus entwickelte Demonstrationsprogramm wurde von den Gutachtern positiv bewertet, konnte jedoch nicht auf Anhieb (1996) in die Foerderung aufgenommen werden. Im November 1997 wurden von der EU-Kommission dann kurzfristig noch 1,5 Mio ECU an Foerderung bewilligt, mit denen ein aktualisierter Projektvorschlag realisiert werden kann. Bereits Mitte 1997 wurde ein kleineres Vorhaben bewilligt, das unter Federfuehrung von Chalmers Industriteknik (CIT) in Schweden beantragt worden war und das vor allem dem Technologietransfer dient. (orig.)

  10. Large Scale Experiments on Spacecraft Fire Safety

    Science.gov (United States)

    Urban, David; Ruff, Gary A.; Minster, Olivier; Fernandez-Pello, A. Carlos; Tien, James S.; Torero, Jose L.; Legros, Guillaume; Eigenbrod, Christian; Smirnov, Nickolay; Fujita, Osamu; hide

    2012-01-01

    Full scale fire testing complemented by computer modelling has provided significant knowhow about the risk, prevention and suppression of fire in terrestrial systems (cars, ships, planes, buildings, mines, and tunnels). In comparison, no such testing has been carried out for manned spacecraft due to the complexity, cost and risk associated with operating a long duration fire safety experiment of a relevant size in microgravity. Therefore, there is currently a gap in knowledge of fire behaviour in spacecraft. The entire body of low-gravity fire research has either been conducted in short duration ground-based microgravity facilities or has been limited to very small fuel samples. Still, the work conducted to date has shown that fire behaviour in low-gravity is very different from that in normal gravity, with differences observed for flammability limits, ignition delay, flame spread behaviour, flame colour and flame structure. As a result, the prediction of the behaviour of fires in reduced gravity is at present not validated. To address this gap in knowledge, a collaborative international project, Spacecraft Fire Safety, has been established with its cornerstone being the development of an experiment (Fire Safety 1) to be conducted on an ISS resupply vehicle, such as the Automated Transfer Vehicle (ATV) or Orbital Cygnus after it leaves the ISS and before it enters the atmosphere. A computer modelling effort will complement the experimental effort. Although the experiment will need to meet rigorous safety requirements to ensure the carrier vehicle does not sustain damage, the absence of a crew removes the need for strict containment of combustion products. This will facilitate the possibility of examining fire behaviour on a scale that is relevant to spacecraft fire safety and will provide unique data for fire model validation. This unprecedented opportunity will expand the understanding of the fundamentals of fire behaviour in spacecraft. The experiment is being

  11. A Negative Finding from a Single Center Study Led to Re-Design of a Large-Scale Clinical Trial of Phytotherapy for Benign Prostatic Hyperplasia: the CAMUS study

    Science.gov (United States)

    Lee, Jeannette Y.; Andriole, Gerald; Avins, Andrew; Crawford, E. David; Foster, Harris; Kaplan, Steven; Kreder, Karl; Kusek, John W.; McCullough, Andrew; McVary, Kevin; Meleth, Sreelatha; Naslund, Michael; Nickel, J. Curtis; Nyberg, Leroy M.; Roehrborn, Claus; Williams, O. Dale; Barry, Michael J.

    2010-01-01

    Background Benign prostatic hyperplasia (BPH), a common condition among older men, confers its morbidity through potentially bothersome lower urinary tract symptoms. Treatments for BPH include drugs such as alpha adrenergic receptor blockers and 5-alpha reductase inhibitors, minimally invasive therapies that use heat to damage or destroy prostate tissue, and surgery including transurethral resection of the prostate. Complementary and alternative medicines are gaining popularity in the U.S. Two phytotherapies commonly used for BPH are extracts of the fruit of Serenoa repens, the Saw palmetto dwarf palm that grows in the Southeastern U.S., and extracts of the bark of Pygeum africanum, the African plum tree. Purpose The objective of the Complementary and Alternative Medicines for Urological Symptoms (CAMUS) clinical trial is to determine if phytotherapy is superior to placebo in the treatment of BPH. Methods CAMUS was originally designed as a 3300-participant, four-arm trial of Serenoa repens, Pygeum africanum, an alpha adrenergic blocking drug, and placebo with time to clinical progression of BPH, a measure of long-term efficacy, as the primary endpoint. Before enrollment started, a randomized, double-blind, placebo-controlled, single institution clinical trial showed that Serenoa repens at the usual dose did not demonstrate any benefit over placebo with respect to symptom relief at one year. Consequently, the focus of CAMUS shifted from evaluating long-term efficacy to determining if any short-term (6-18 month) symptom relief could be achieved with increasing doses of Serenoa repens, the phytotherapy most commonly used in the U.S. for BPH. Results Results are anticipated in 2011. Conclusions Trial design occurs in an environment of continually evolving information. In this case, emerging results from another trial suggested that a study of long-term efficacy was premature, and that an effective dose and preparation of Serenoa repens had to be established before

  12. Analysis using large-scale ringing data

    Directory of Open Access Journals (Sweden)

    Baillie, S. R.

    2004-06-01

    survival and recruitment estimates from the French CES scheme to assess the relative contributions of survival and recruitment to overall population changes. He develops a novel approach to modelling survival rates from such multi–site data by using within–year recaptures to provide a covariate of between–year recapture rates. This provided parsimonious models of variation in recapture probabilities between sites and years. The approach provides promising results for the four species investigated and can potentially be extended to similar data from other CES/MAPS schemes. The final paper by Blandine Doligez, David Thomson and Arie van Noordwijk (Doligez et al., 2004 illustrates how large-scale studies of population dynamics can be important for evaluating the effects of conservation measures. Their study is concerned with the reintroduction of White Stork populations to the Netherlands where a re–introduction programme started in 1969 had resulted in a breeding population of 396 pairs by 2000. They demonstrate the need to consider a wide range of models in order to account for potential age, time, cohort and “trap–happiness” effects. As the data are based on resightings such trap–happiness must reflect some form of heterogeneity in resighting probabilities. Perhaps surprisingly, the provision of supplementary food did not influence survival, but it may havehad an indirect effect via the alteration of migratory behaviour. Spatially explicit modelling of data gathered at many sites inevitably results in starting models with very large numbers of parameters. The problem is often complicated further by having relatively sparse data at each site, even where the total amount of data gathered is very large. Both Julliard (2004 and Doligez et al. (2004 give explicit examples of problems caused by needing to handle very large numbers of parameters and show how they overcame them for their particular data sets. Such problems involve both the choice of appropriate

  13. Automatic management software for large-scale cluster system

    International Nuclear Information System (INIS)

    Weng Yunjian; Chinese Academy of Sciences, Beijing; Sun Gongxing

    2007-01-01

    At present, the large-scale cluster system faces to the difficult management. For example the manager has large work load. It needs to cost much time on the management and the maintenance of large-scale cluster system. The nodes in large-scale cluster system are very easy to be chaotic. Thousands of nodes are put in big rooms so that some managers are very easy to make the confusion with machines. How do effectively carry on accurate management under the large-scale cluster system? The article introduces ELFms in the large-scale cluster system. Furthermore, it is proposed to realize the large-scale cluster system automatic management. (authors)

  14. Large scale chromatographic separations using continuous displacement chromatography (CDC)

    International Nuclear Information System (INIS)

    Taniguchi, V.T.; Doty, A.W.; Byers, C.H.

    1988-01-01

    A process for large scale chromatographic separations using a continuous chromatography technique is described. The process combines the advantages of large scale batch fixed column displacement chromatography with conventional analytical or elution continuous annular chromatography (CAC) to enable large scale displacement chromatography to be performed on a continuous basis (CDC). Such large scale, continuous displacement chromatography separations have not been reported in the literature. The process is demonstrated with the ion exchange separation of a binary lanthanide (Nd/Pr) mixture. The process is, however, applicable to any displacement chromatography separation that can be performed using conventional batch, fixed column chromatography

  15. Clinical use of enteral immune nutrition in patients with acute exacerbation of chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Zhi-cheng ZHANG

    2015-06-01

    Full Text Available Objective To investigate the use of enteral immune nutrition preparation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD, regard its efficacy in improving nutritional status, and its influence on immunity and the status of acute inflammatory reaction of the patients. Methods Sixty-two AECOPD patients requiring mechanical ventilation in ICU of our hospital were randomly divided into two groups: immune nutrition group [study group, n=32, receiving Ruineng (a product of Huarui Pharmaceutical Ltd., which contained essential fatty acids, Omega-3 fatty acids, and energy 1.3 kcal/ml] and conventional nutrition group (control group, n=30, receiving the hospital self-made homogenized diet with 1.2 kal/ml. Patients in the two groups took enteral nutrition of equal calorie, and it was given by nasointestinal tube. On the day of admission and the 14th and 18th after admission, venous blood was obtained for the determination of serum albumin, prealbumin, transferrin, C reactive protein (CRP, tumor necrosis factor-α (TNF-α, and interleukin-6 (IL-6. At the same time upper arm muscle circumference (MAMC was measured at the bed side. The 14-day off-respirator rate and mechanical ventilation time within 28 days were compared between the two groups. Results The 14-day off-respirator rate was higher in study group than in control group (P0.05. Conclusions Compared with homogenized diet, immune enteral nutrition could better improve the nutritional status and immune function, lower the acute inflammatory response level, increase the success rate of early off-respirator in AECOPD patients, therefore, enteral immune nutrition preparation is a better nutrition support solution for AECOPD. DOI: 10.11855/j.issn.0577-7402.2015.05.17

  16. Frequency of changing enteral alimentation bags and tubing, and adverse clinical outcomes in patients in a long term care facility.

    Science.gov (United States)

    Graham, S; McIntyre, M; Chicoine, J; Gerard, B; Laughren, R; Cowley, G; Morrison, J; Aoki, F Y; Nicolle, L E

    1993-01-01

    Enteral alimentation, given via nasogastric or gastrostomy tubes, is a well established practice to provide nutrition for patients with significant neurological injury. The frequency with which enteral feeding bags and tubes require change and potential adverse effects associated with bacterial contamination of tube feeds remain controversial. The authors studied different times between enteral feeding bag and tube changes, and the effect on adverse clinical outcomes in residents of a long term care facility. In the first study, residents were randomized to 24 h (n = 2), 48 h (n = 3) or 72 h (n = 6) tube feeding and bag changes with clinical status monitored in a standardized fashion for six months. In the second study, patients were randomized to 24 h (n = 6) or 72 h (n = 6) changes. Patient-days of follow-up were 382, 574 and 1000 for the three arms of the first study period and 556 and 496 for the two arms of the second study. No differences in potential clinical adverse events--including fever, gastrointestinal symptoms or pneumonia--were observed with different durations of tubing change. This study suggests it is appropriate to change alimentation tube and feeding bags every 72 h (rather than every 24 h). The less frequent changes will decrease supply costs and free nursing time for other activities.

  17. [Clinical observation of preoperative administration of enteral nutrition support in gastric cancer patients at risk of malnutrition].

    Science.gov (United States)

    Chen, Bo; Zhou, Yong; Yang, Ping; Qin, Xian-peng; Li, Ning-ning; He, Dan; Feng, Jin-yan; Yan, Chuan-jing; Wu, Xiao-ting

    2013-11-01

    To evaluate safety and efficacy of preoperative administration of enteral nutrition support in gastric cancer patients at risk of malnutrition. A single center randomized controlled clinical trial was performed in 60 gastric cancer patients in West China Hospital from May to October 2012. Thirty patients were given enteral nutrition support(Ensure(R)) manufactured by Abbott Laboratories for ten consecutive days before surgical operation in the treatment group, and 30 patients were given an isocaloric and isonitrogenous homogenized diet in the control group for 10 days as well. The laboratory parameters of nutritional status and hepatorenal function were observed and compared between the two groups on admission, preoperative day 1 and postoperative day 3, respectively. Clinical observations, such as nausea and vomiting, were carried out until patients were discharged. Before the intervention, there were no significant differences in the baseline characteristics between the two groups. The levels of serum albumin [(33.9±5.6) g/L vs. (31.0±5.3) g/L, P0.05). Moreover, two patients with nausea and one with vomiting in each group were found. In clinical observation period, no severe treatment-related adverse event were observed. The enteral supplement with Ensure(R) in gastric cancer patients at risk of malnutrition during preoperative period is effective and safe, which is superior to homogenized diet and an appropriate choice for gastric cancer patients with nutritional risk.

  18. Prospects for large scale electricity storage in Denmark

    DEFF Research Database (Denmark)

    Krog Ekman, Claus; Jensen, Søren Højgaard

    2010-01-01

    In a future power systems with additional wind power capacity there will be an increased need for large scale power management as well as reliable balancing and reserve capabilities. Different technologies for large scale electricity storage provide solutions to the different challenges arising w...

  19. Large-scale matrix-handling subroutines 'ATLAS'

    International Nuclear Information System (INIS)

    Tsunematsu, Toshihide; Takeda, Tatsuoki; Fujita, Keiichi; Matsuura, Toshihiko; Tahara, Nobuo

    1978-03-01

    Subroutine package ''ATLAS'' has been developed for handling large-scale matrices. The package is composed of four kinds of subroutines, i.e., basic arithmetic routines, routines for solving linear simultaneous equations and for solving general eigenvalue problems and utility routines. The subroutines are useful in large scale plasma-fluid simulations. (auth.)

  20. Large-scale Agricultural Land Acquisitions in West Africa | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project will examine large-scale agricultural land acquisitions in nine West African countries -Burkina Faso, Guinea-Bissau, Guinea, Benin, Mali, Togo, Senegal, Niger, and Côte d'Ivoire. ... They will use the results to increase public awareness and knowledge about the consequences of large-scale land acquisitions.

  1. Large-scale synthesis of YSZ nanopowder by Pechini method

    Indian Academy of Sciences (India)

    Administrator

    structure and chemical purity of 99⋅1% by inductively coupled plasma optical emission spectroscopy on a large scale. Keywords. Sol–gel; yttria-stabilized zirconia; large scale; nanopowder; Pechini method. 1. Introduction. Zirconia has attracted the attention of many scientists because of its tremendous thermal, mechanical ...

  2. A comparative clinical study of efficacy of microimmuno assay with WIDAL-test in enteric fever in children

    Directory of Open Access Journals (Sweden)

    Gandarajapura Nagaraj Madhu

    2014-01-01

    Full Text Available The diagnosis of typhoid fever in young children is also a dilemma because of its manifestations and typical presentation may not be seen in all cases. Antibodies to Salmonella typhi antigen are developed in the human body, which can be detected as a diagnostic test for the enteric fever. Objective: This study was undertaken to compare the efficacy of WIDAL-test with micro-immunoassay (dot enzyme immunosorbent assay. Method: 40 cases of clinically suspected enteric fever cases were included in this study. Result: In the present study, nearly 92% were positive for micro immunoassay (dot-enzyme immunosorbent assay by Enterocheck-WB kit, 80% were positive for WIDAL and only 15% were culture positive. Immunoassay positive, but WIDAL negative cases were 20%, whereas WIDAL positive and immunoassay negative cases were only 7.5%. The positive predictivity of micro-immunoassay in diagnosing enteric fever is better than WIDAL both in 1st and 2nd week of illness. Micro-immunoassay done in the study was rapid in diagnosing the case. Conclusion: It is concluded from the present study that the micro-immunoassay (Enterocheck-WB is better than WIDAL-test in the diagnosis of enteric fever in children.

  3. Algorithm 896: LSA: Algorithms for Large-Scale Optimization

    Czech Academy of Sciences Publication Activity Database

    Lukšan, Ladislav; Matonoha, Ctirad; Vlček, Jan

    2009-01-01

    Roč. 36, č. 3 (2009), 16-1-16-29 ISSN 0098-3500 R&D Pro jects: GA AV ČR IAA1030405; GA ČR GP201/06/P397 Institutional research plan: CEZ:AV0Z10300504 Keywords : algorithms * design * large-scale optimization * large-scale nonsmooth optimization * large-scale nonlinear least squares * large-scale nonlinear minimax * large-scale systems of nonlinear equations * sparse pro blems * partially separable pro blems * limited-memory methods * discrete Newton methods * quasi-Newton methods * primal interior-point methods Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 1.904, year: 2009

  4. Large-scale exploration and analysis of drug combinations.

    Science.gov (United States)

    Li, Peng; Huang, Chao; Fu, Yingxue; Wang, Jinan; Wu, Ziyin; Ru, Jinlong; Zheng, Chunli; Guo, Zihu; Chen, Xuetong; Zhou, Wei; Zhang, Wenjuan; Li, Yan; Chen, Jianxin; Lu, Aiping; Wang, Yonghua

    2015-06-15

    Drug combinations are a promising strategy for combating complex diseases by improving the efficacy and reducing corresponding side effects. Currently, a widely studied problem in pharmacology is to predict effective drug combinations, either through empirically screening in clinic or pure experimental trials. However, the large-scale prediction of drug combination by a systems method is rarely considered. We report a systems pharmacology framework to predict drug combinations (PreDCs) on a computational model, termed probability ensemble approach (PEA), for analysis of both the efficacy and adverse effects of drug combinations. First, a Bayesian network integrating with a similarity algorithm is developed to model the combinations from drug molecular and pharmacological phenotypes, and the predictions are then assessed with both clinical efficacy and adverse effects. It is illustrated that PEA can predict the combination efficacy of drugs spanning different therapeutic classes with high specificity and sensitivity (AUC = 0.90), which was further validated by independent data or new experimental assays. PEA also evaluates the adverse effects (AUC = 0.95) quantitatively and detects the therapeutic indications for drug combinations. Finally, the PreDC database includes 1571 known and 3269 predicted optimal combinations as well as their potential side effects and therapeutic indications. The PreDC database is available at http://sm.nwsuaf.edu.cn/lsp/predc.php. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. An Novel Architecture of Large-scale Communication in IOT

    Science.gov (United States)

    Ma, Wubin; Deng, Su; Huang, Hongbin

    2018-03-01

    In recent years, many scholars have done a great deal of research on the development of Internet of Things and networked physical systems. However, few people have made the detailed visualization of the large-scale communications architecture in the IOT. In fact, the non-uniform technology between IPv6 and access points has led to a lack of broad principles of large-scale communications architectures. Therefore, this paper presents the Uni-IPv6 Access and Information Exchange Method (UAIEM), a new architecture and algorithm that addresses large-scale communications in the IOT.

  6. Large scale and big data processing and management

    CERN Document Server

    Sakr, Sherif

    2014-01-01

    Large Scale and Big Data: Processing and Management provides readers with a central source of reference on the data management techniques currently available for large-scale data processing. Presenting chapters written by leading researchers, academics, and practitioners, it addresses the fundamental challenges associated with Big Data processing tools and techniques across a range of computing environments.The book begins by discussing the basic concepts and tools of large-scale Big Data processing and cloud computing. It also provides an overview of different programming models and cloud-bas

  7. Comparison Between Overtopping Discharge in Small and Large Scale Models

    DEFF Research Database (Denmark)

    Helgason, Einar; Burcharth, Hans F.

    2006-01-01

    The present paper presents overtopping measurements from small scale model test performed at the Haudraulic & Coastal Engineering Laboratory, Aalborg University, Denmark and large scale model tests performed at the Largde Wave Channel,Hannover, Germany. Comparison between results obtained from...... small and large scale model tests show no clear evidence of scale effects for overtopping above a threshold value. In the large scale model no overtopping was measured for waveheights below Hs = 0.5m as the water sunk into the voids between the stones on the crest. For low overtopping scale effects...

  8. Probabilistic discrimination between large-scale environments of intensifying and decaying African Easterly Waves

    Energy Technology Data Exchange (ETDEWEB)

    Agudelo, Paula A. [Area Hidrometria e Instrumentacion Carrera, Empresas Publicas de Medellin, Medellin (Colombia); Hoyos, Carlos D.; Curry, Judith A.; Webster, Peter J. [School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA (United States)

    2011-04-15

    About 50-60% of Atlantic tropical cyclones (TCs) including nearly 85% of intense hurricanes have their origins as African Easterly Waves (AEWs). However, predicting the likelihood of AEW intensification remains a difficult task. We have developed a Bayesian diagnostic methodology to understand genesis of North Atlantic TCs spawned by AEWs through the examination of the characteristics of the AEW itself together with the large-scale environment, resulting in a probabilistic discrimination between large-scale environments associated with intensifying and decaying AEWs. The methodology is based on a new objective and automatic AEW tracking scheme used for the period 1980 to 2001 based on spatio-temporally Fourier-filtered relative vorticity and meridional winds at different levels and outgoing long wave radiation. Using the AEW and Hurricane Best Track Files (HURDAT) data sets, probability density functions of environmental variables that discriminate between AEWs that decay, become TCs or become major hurricanes are determined. Results indicate that the initial amplitude of the AEWs is a major determinant for TC genesis, and that TC genesis risk increases when the wave enters an environment characterized by pre-existing large-scale convergence and moist convection. For the prediction of genesis, the most useful variables are column integrated heating, vertical velocity and specific humidity, and a combined form of divergence and vertical velocity and SST. It is also found that the state of the large-scale environment modulates the annual cycle and interannual variability of the AEW intensification efficiency. (orig.)

  9. Large-scale land transformations in Indonesia: The role of ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... enable timely responses to the impacts of large-scale land transformations in Central Kalimantan ... In partnership with UNESCO's Organization for Women in Science for the ... New funding opportunity for gender equality and climate change.

  10. Resolute large scale mining company contribution to health services of

    African Journals Online (AJOL)

    Resolute large scale mining company contribution to health services of Lusu ... in terms of socio economic, health, education, employment, safe drinking water, ... The data were analyzed using Scientific Package for Social Science (SPSS).

  11. Personalized Opportunistic Computing for CMS at Large Scale

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    **Douglas Thain** is an Associate Professor of Computer Science and Engineering at the University of Notre Dame, where he designs large scale distributed computing systems to power the needs of advanced science and...

  12. Bottom-Up Accountability Initiatives and Large-Scale Land ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Corey Piccioni

    fuel/energy, climate, and finance has occurred and one of the most ... this wave of large-scale land acquisitions. In fact, esti- ... Environmental Rights Action/Friends of the Earth,. Nigeria ... map the differentiated impacts (gender, ethnicity,.

  13. Large-scale linear programs in planning and prediction.

    Science.gov (United States)

    2017-06-01

    Large-scale linear programs are at the core of many traffic-related optimization problems in both planning and prediction. Moreover, many of these involve significant uncertainty, and hence are modeled using either chance constraints, or robust optim...

  14. Bottom-Up Accountability Initiatives and Large-Scale Land ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... Security can help increase accountability for large-scale land acquisitions in ... to build decent economic livelihoods and participate meaningfully in decisions ... its 2017 call for proposals to establish Cyber Policy Centres in the Global South.

  15. Amplification of large-scale magnetic field in nonhelical magnetohydrodynamics

    KAUST Repository

    Kumar, Rohit

    2017-08-11

    It is typically assumed that the kinetic and magnetic helicities play a crucial role in the growth of large-scale dynamo. In this paper, we demonstrate that helicity is not essential for the amplification of large-scale magnetic field. For this purpose, we perform nonhelical magnetohydrodynamic (MHD) simulation, and show that the large-scale magnetic field can grow in nonhelical MHD when random external forcing is employed at scale 1/10 the box size. The energy fluxes and shell-to-shell transfer rates computed using the numerical data show that the large-scale magnetic energy grows due to the energy transfers from the velocity field at the forcing scales.

  16. Needs, opportunities, and options for large scale systems research

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, G.L.

    1984-10-01

    The Office of Energy Research was recently asked to perform a study of Large Scale Systems in order to facilitate the development of a true large systems theory. It was decided to ask experts in the fields of electrical engineering, chemical engineering and manufacturing/operations research for their ideas concerning large scale systems research. The author was asked to distribute a questionnaire among these experts to find out their opinions concerning recent accomplishments and future research directions in large scale systems research. He was also requested to convene a conference which included three experts in each area as panel members to discuss the general area of large scale systems research. The conference was held on March 26--27, 1984 in Pittsburgh with nine panel members, and 15 other attendees. The present report is a summary of the ideas presented and the recommendations proposed by the attendees.

  17. Large-Scale 3D Printing: The Way Forward

    Science.gov (United States)

    Jassmi, Hamad Al; Najjar, Fady Al; Ismail Mourad, Abdel-Hamid

    2018-03-01

    Research on small-scale 3D printing has rapidly evolved, where numerous industrial products have been tested and successfully applied. Nonetheless, research on large-scale 3D printing, directed to large-scale applications such as construction and automotive manufacturing, yet demands a great a great deal of efforts. Large-scale 3D printing is considered an interdisciplinary topic and requires establishing a blended knowledge base from numerous research fields including structural engineering, materials science, mechatronics, software engineering, artificial intelligence and architectural engineering. This review article summarizes key topics of relevance to new research trends on large-scale 3D printing, particularly pertaining (1) technological solutions of additive construction (i.e. the 3D printers themselves), (2) materials science challenges, and (3) new design opportunities.

  18. Financing a large-scale picture archival and communication system.

    Science.gov (United States)

    Goldszal, Alberto F; Bleshman, Michael H; Bryan, R Nick

    2004-01-01

    An attempt to finance a large-scale multi-hospital picture archival and communication system (PACS) solely based on cost savings from current film operations is reported. A modified Request for Proposal described the technical requirements, PACS architecture, and performance targets. The Request for Proposal was complemented by a set of desired financial goals-the main one being the ability to use film savings to pay for the implementation and operation of the PACS. Financing of the enterprise-wide PACS was completed through an operating lease agreement including all PACS equipment, implementation, service, and support for an 8-year term, much like a complete outsourcing. Equipment refreshes, both hardware and software, are included. Our agreement also linked the management of the digital imaging operation (PACS) and the traditional film printing, shifting the operational risks of continued printing and costs related to implementation delays to the PACS vendor. An additional optimization step provided the elimination of the negative film budget variances in the beginning of the project when PACS costs tend to be higher than film and film-related expenses. An enterprise-wide PACS has been adopted to achieve clinical workflow improvements and cost savings. PACS financing was solely based on film savings, which included the entire digital solution (PACS) and any residual film printing. These goals were achieved with simultaneous elimination of any over-budget scenarios providing a non-negative cash flow in each year of an 8-year term.

  19. No Large Scale Curvature Perturbations during Waterfall of Hybrid Inflation

    OpenAIRE

    Abolhasani, Ali Akbar; Firouzjahi, Hassan

    2010-01-01

    In this paper the possibility of generating large scale curvature perturbations induced from the entropic perturbations during the waterfall phase transition of standard hybrid inflation model is studied. We show that whether or not appreciable amounts of large scale curvature perturbations are produced during the waterfall phase transition depend crucially on the competition between the classical and the quantum mechanical back-reactions to terminate inflation. If one considers only the clas...

  20. Bayesian hierarchical model for large-scale covariance matrix estimation.

    Science.gov (United States)

    Zhu, Dongxiao; Hero, Alfred O

    2007-12-01

    Many bioinformatics problems implicitly depend on estimating large-scale covariance matrix. The traditional approaches tend to give rise to high variance and low accuracy due to "overfitting." We cast the large-scale covariance matrix estimation problem into the Bayesian hierarchical model framework, and introduce dependency between covariance parameters. We demonstrate the advantages of our approaches over the traditional approaches using simulations and OMICS data analysis.

  1. Benefits of transactive memory systems in large-scale development

    OpenAIRE

    Aivars, Sablis

    2016-01-01

    Context. Large-scale software development projects are those consisting of a large number of teams, maybe even spread across multiple locations, and working on large and complex software tasks. That means that neither a team member individually nor an entire team holds all the knowledge about the software being developed and teams have to communicate and coordinate their knowledge. Therefore, teams and team members in large-scale software development projects must acquire and manage expertise...

  2. Capabilities of the Large-Scale Sediment Transport Facility

    Science.gov (United States)

    2016-04-01

    pump flow meters, sediment trap weigh tanks , and beach profiling lidar. A detailed discussion of the original LSTF features and capabilities can be...ERDC/CHL CHETN-I-88 April 2016 Approved for public release; distribution is unlimited. Capabilities of the Large-Scale Sediment Transport...describes the Large-Scale Sediment Transport Facility (LSTF) and recent upgrades to the measurement systems. The purpose of these upgrades was to increase

  3. Comparative Analysis of Different Protocols to Manage Large Scale Networks

    OpenAIRE

    Anil Rao Pimplapure; Dr Jayant Dubey; Prashant Sen

    2013-01-01

    In recent year the numbers, complexity and size is increased in Large Scale Network. The best example of Large Scale Network is Internet, and recently once are Data-centers in Cloud Environment. In this process, involvement of several management tasks such as traffic monitoring, security and performance optimization is big task for Network Administrator. This research reports study the different protocols i.e. conventional protocols like Simple Network Management Protocol and newly Gossip bas...

  4. Trends in large-scale testing of reactor structures

    International Nuclear Information System (INIS)

    Blejwas, T.E.

    2003-01-01

    Large-scale tests of reactor structures have been conducted at Sandia National Laboratories since the late 1970s. This paper describes a number of different large-scale impact tests, pressurization tests of models of containment structures, and thermal-pressure tests of models of reactor pressure vessels. The advantages of large-scale testing are evident, but cost, in particular limits its use. As computer models have grown in size, such as number of degrees of freedom, the advent of computer graphics has made possible very realistic representation of results - results that may not accurately represent reality. A necessary condition to avoiding this pitfall is the validation of the analytical methods and underlying physical representations. Ironically, the immensely larger computer models sometimes increase the need for large-scale testing, because the modeling is applied to increasing more complex structural systems and/or more complex physical phenomena. Unfortunately, the cost of large-scale tests is a disadvantage that will likely severely limit similar testing in the future. International collaborations may provide the best mechanism for funding future programs with large-scale tests. (author)

  5. Deaths associated with insertion of nasogastric tubes for enteral nutrition in the medical intensive care unit: Clinical and autopsy findings

    Science.gov (United States)

    Smith, Avery L.; Santa Ana, Carol A.; Fordtran, John S.; Guileyardo, Joseph M.

    2018-01-01

    ABSTRACT It is generally assumed that blind insertion of nasogastric tubes for enteral nutrition in patients admitted to medical intensive care units is safe; that is, does not result in life-threatening injury. If death occurs in temporal association with insertion of a nasogastric tube, caregivers typically attribute it to underlying diseases, with little or no consideration of iatrogenic death due to tube insertion. The clinical and autopsy results in three recent cases at Baylor University Medical Center challenge the validity of these notions. PMID:29904295

  6. Clinical study on influences of enteric coated aspirin on blood pressure and blood pressure variability.

    Science.gov (United States)

    Ji, A-L; Chen, W-W; Huang, W-J

    2016-12-01

    We investigated the effects of oral administration of enteric coated aspirin (ASA) on blood pressure and blood pressure variability of hypertension patients before sleep. We observed 150 hypertension cases, classified as Grade 1-2, from September 2006 to March 2008. They are divided into a control group with 30 cases, ASA I group with 60 cases and ASA II group with 60 cases randomly. Subjects in the control group had proper diets, were losing weight, exercising and maintaining a healthy mentality and were taking 30 mg Adalat orally once a day. Based on the treatment of control group, patients in ASA I group were administered 0.1 g Bayaspirin (produced by Bayer Company) at drought in the morning. Also, based on the treatment of control group, patients in ASA II group were administered 0.1 g Bayaspirin at draught before sleep. The course of treatment is 3 months and then after the treatment, decreasing blood pressure and blood pressure variability conditions in three groups will be compared. Through the comparison of ASA II group with the control group, they have differences in terms of systolic blood pressure (SBP), diastolic blood pressure (DBP), decreasing range of blood pressure and blood pressure variability (p sleep has synergistic effects on decreasing blood pressure of hypertension patients and improving blood pressure variability.

  7. Phylogenetic distribution of large-scale genome patchiness

    Directory of Open Access Journals (Sweden)

    Hackenberg Michael

    2008-04-01

    Full Text Available Abstract Background The phylogenetic distribution of large-scale genome structure (i.e. mosaic compositional patchiness has been explored mainly by analytical ultracentrifugation of bulk DNA. However, with the availability of large, good-quality chromosome sequences, and the recently developed computational methods to directly analyze patchiness on the genome sequence, an evolutionary comparative analysis can be carried out at the sequence level. Results The local variations in the scaling exponent of the Detrended Fluctuation Analysis are used here to analyze large-scale genome structure and directly uncover the characteristic scales present in genome sequences. Furthermore, through shuffling experiments of selected genome regions, computationally-identified, isochore-like regions were identified as the biological source for the uncovered large-scale genome structure. The phylogenetic distribution of short- and large-scale patchiness was determined in the best-sequenced genome assemblies from eleven eukaryotic genomes: mammals (Homo sapiens, Pan troglodytes, Mus musculus, Rattus norvegicus, and Canis familiaris, birds (Gallus gallus, fishes (Danio rerio, invertebrates (Drosophila melanogaster and Caenorhabditis elegans, plants (Arabidopsis thaliana and yeasts (Saccharomyces cerevisiae. We found large-scale patchiness of genome structure, associated with in silico determined, isochore-like regions, throughout this wide phylogenetic range. Conclusion Large-scale genome structure is detected by directly analyzing DNA sequences in a wide range of eukaryotic chromosome sequences, from human to yeast. In all these genomes, large-scale patchiness can be associated with the isochore-like regions, as directly detected in silico at the sequence level.

  8. Clinical, hematological, and biochemical findings in puppies with coronavirus and parvovirus enteritis

    Science.gov (United States)

    Castro, Tatiana X.; Cubel Garcia, Rita de Cássia N.; Gonçalves, Luciana P. S.; Costa, Erika M.; Marcello, Gracy C.G.; Labarthe, Norma V.; Mendes-de-Almeida, Flavya

    2013-01-01

    The clinical and laboratory findings in puppies naturally infected with canine coronavirus (CCoV) and/or canine parvovirus (CPV) were compared with findings in uninfected puppies. Lymphopenia was the only parameter related to CCoV infection that was statistically significant; vomiting, anorexia, lethargy, hemorrhagic fluid diarrhea, leukopenia, lymphopenia, thrombocytopenia, hypoglycemia, and hypoproteinemia were correlated with CPV infection. PMID:24155496

  9. Has Modern Biology Entered the Mouth? The Clinical Impact of Biological Research.

    Science.gov (United States)

    Baum, Bruce J.

    1991-01-01

    Three areas of biological research that are beginning to have an impact on clinical medicine are examined, including molecular biology, cell biology, and biotechnology. It is concluded that oral biologists and educators must work cooperatively to bring rapid biological and biomedical advances into dental training in a meaningful way. (MSE)

  10. Women entering clinical psychology: Q-sort narratives of career attraction of female clinical psychology trainees in the UK

    OpenAIRE

    Baker, Martyn; Nash, Jen

    2011-01-01

    The great majority of the UK clinical psychology workforce is female, and this fact prompted an examination of the various ways clinical psychology might be seen as attractive to women – a neglected research topic. Female clinical psychology trainees from a variety of training programmes Q-sorted statements of potential job attractors. The process of analysis is outlined, before most of the article is devoted to explicating the five narratives of attraction generated: making a difference, wai...

  11. Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials.

    Science.gov (United States)

    Koretz, Ronald L; Avenell, Alison; Lipman, Timothy O; Braunschweig, Carol L; Milne, Anne C

    2007-02-01

    Both parenteral nutrition (PN) and enteral nutrition (EN) are widely advocated as adjunctive care in patients with various diseases. A systematic review of 82 randomized controlled trials (RCTs) of PN published in 2001 found little, if any, effect on mortality, morbidity, or duration of hospital stay; in some situations, PN increased infectious complication rates. The objective was to assess the effect of EN or volitional nutrition support (VNS) in individual disease states from available RCTs. We conducted a systematic review. RCTs comparing EN or VNS with untreated controls, or comparing EN with PN, were identified and separated according to the underlying disease state. Meta-analysis was performed when at least three RCTs provided data. The evidence from the RCTs was summarized into one of five grades. A or B, respectively, indicated the presence of strong or weak (low-quality RCTs) evidence supporting the use of the intervention. C indicated a lack of adequate evidence to make any decision about efficacy. D indicated that limited data could not support the intervention. E indicated either that strong data found no effect, or that either strong or weak data suggested that the intervention caused harm. RCTs could include either hospitalized or nonhospitalized patients. The EN or VNS had to be provided as part of a treatment plan for an underlying disease process. The RCT had to compare recipients of either EN or VNS with controls not receiving any type of artificial nutrition or had to compare recipients of EN with recipients of PN. These were mortality, morbidity (disease specific), duration of hospitalization, cost, or interventional complications. SUMMARY OF GRADING: A: No indication was identified. B: EN or VNS in the perioperative patient or in patients with chronic liver disease; EN in critically ill patients or low birth weight infants (trophic feeding); VNS in malnourished geriatric patients. (The low-quality trials found a significant difference in

  12. PKI security in large-scale healthcare networks.

    Science.gov (United States)

    Mantas, Georgios; Lymberopoulos, Dimitrios; Komninos, Nikos

    2012-06-01

    During the past few years a lot of PKI (Public Key Infrastructures) infrastructures have been proposed for healthcare networks in order to ensure secure communication services and exchange of data among healthcare professionals. However, there is a plethora of challenges in these healthcare PKI infrastructures. Especially, there are a lot of challenges for PKI infrastructures deployed over large-scale healthcare networks. In this paper, we propose a PKI infrastructure to ensure security in a large-scale Internet-based healthcare network connecting a wide spectrum of healthcare units geographically distributed within a wide region. Furthermore, the proposed PKI infrastructure facilitates the trust issues that arise in a large-scale healthcare network including multi-domain PKI infrastructures.

  13. Large-Scale Agriculture and Outgrower Schemes in Ethiopia

    DEFF Research Database (Denmark)

    Wendimu, Mengistu Assefa

    , the impact of large-scale agriculture and outgrower schemes on productivity, household welfare and wages in developing countries is highly contentious. Chapter 1 of this thesis provides an introduction to the study, while also reviewing the key debate in the contemporary land ‘grabbing’ and historical large...... sugarcane outgrower scheme on household income and asset stocks. Chapter 5 examines the wages and working conditions in ‘formal’ large-scale and ‘informal’ small-scale irrigated agriculture. The results in Chapter 2 show that moisture stress, the use of untested planting materials, and conflict over land...... commands a higher wage than ‘formal’ large-scale agriculture, while rather different wage determination mechanisms exist in the two sectors. Human capital characteristics (education and experience) partly explain the differences in wages within the formal sector, but play no significant role...

  14. Seismic safety in conducting large-scale blasts

    Science.gov (United States)

    Mashukov, I. V.; Chaplygin, V. V.; Domanov, V. P.; Semin, A. A.; Klimkin, M. A.

    2017-09-01

    In mining enterprises to prepare hard rocks for excavation a drilling and blasting method is used. With the approach of mining operations to settlements the negative effect of large-scale blasts increases. To assess the level of seismic impact of large-scale blasts the scientific staff of Siberian State Industrial University carried out expertise for coal mines and iron ore enterprises. Determination of the magnitude of surface seismic vibrations caused by mass explosions was performed using seismic receivers, an analog-digital converter with recording on a laptop. The registration results of surface seismic vibrations during production of more than 280 large-scale blasts at 17 mining enterprises in 22 settlements are presented. The maximum velocity values of the Earth’s surface vibrations are determined. The safety evaluation of seismic effect was carried out according to the permissible value of vibration velocity. For cases with exceedance of permissible values recommendations were developed to reduce the level of seismic impact.

  15. Balancing modern Power System with large scale of wind power

    DEFF Research Database (Denmark)

    Basit, Abdul; Altin, Müfit; Hansen, Anca Daniela

    2014-01-01

    Power system operators must ensure robust, secure and reliable power system operation even with a large scale integration of wind power. Electricity generated from the intermittent wind in large propor-tion may impact on the control of power system balance and thus deviations in the power system...... frequency in small or islanded power systems or tie line power flows in interconnected power systems. Therefore, the large scale integration of wind power into the power system strongly concerns the secure and stable grid operation. To ensure the stable power system operation, the evolving power system has...... to be analysed with improved analytical tools and techniques. This paper proposes techniques for the active power balance control in future power systems with the large scale wind power integration, where power balancing model provides the hour-ahead dispatch plan with reduced planning horizon and the real time...

  16. The role of large scale motions on passive scalar transport

    Science.gov (United States)

    Dharmarathne, Suranga; Araya, Guillermo; Tutkun, Murat; Leonardi, Stefano; Castillo, Luciano

    2014-11-01

    We study direct numerical simulation (DNS) of turbulent channel flow at Reτ = 394 to investigate effect of large scale motions on fluctuating temperature field which forms a passive scalar field. Statistical description of the large scale features of the turbulent channel flow is obtained using two-point correlations of velocity components. Two-point correlations of fluctuating temperature field is also examined in order to identify possible similarities between velocity and temperature fields. The two-point cross-correlations betwen the velocity and temperature fluctuations are further analyzed to establish connections between these two fields. In addition, we use proper orhtogonal decompotion (POD) to extract most dominant modes of the fields and discuss the coupling of large scale features of turbulence and the temperature field.

  17. Large-Scale Structure and Hyperuniformity of Amorphous Ices

    Science.gov (United States)

    Martelli, Fausto; Torquato, Salvatore; Giovambattista, Nicolas; Car, Roberto

    2017-09-01

    We investigate the large-scale structure of amorphous ices and transitions between their different forms by quantifying their large-scale density fluctuations. Specifically, we simulate the isothermal compression of low-density amorphous ice (LDA) and hexagonal ice to produce high-density amorphous ice (HDA). Both HDA and LDA are nearly hyperuniform; i.e., they are characterized by an anomalous suppression of large-scale density fluctuations. By contrast, in correspondence with the nonequilibrium phase transitions to HDA, the presence of structural heterogeneities strongly suppresses the hyperuniformity and the system becomes hyposurficial (devoid of "surface-area fluctuations"). Our investigation challenges the largely accepted "frozen-liquid" picture, which views glasses as structurally arrested liquids. Beyond implications for water, our findings enrich our understanding of pressure-induced structural transformations in glasses.

  18. Large-scale networks in engineering and life sciences

    CERN Document Server

    Findeisen, Rolf; Flockerzi, Dietrich; Reichl, Udo; Sundmacher, Kai

    2014-01-01

    This edited volume provides insights into and tools for the modeling, analysis, optimization, and control of large-scale networks in the life sciences and in engineering. Large-scale systems are often the result of networked interactions between a large number of subsystems, and their analysis and control are becoming increasingly important. The chapters of this book present the basic concepts and theoretical foundations of network theory and discuss its applications in different scientific areas such as biochemical reactions, chemical production processes, systems biology, electrical circuits, and mobile agents. The aim is to identify common concepts, to understand the underlying mathematical ideas, and to inspire discussions across the borders of the various disciplines.  The book originates from the interdisciplinary summer school “Large Scale Networks in Engineering and Life Sciences” hosted by the International Max Planck Research School Magdeburg, September 26-30, 2011, and will therefore be of int...

  19. Large Scale Processes and Extreme Floods in Brazil

    Science.gov (United States)

    Ribeiro Lima, C. H.; AghaKouchak, A.; Lall, U.

    2016-12-01

    Persistent large scale anomalies in the atmospheric circulation and ocean state have been associated with heavy rainfall and extreme floods in water basins of different sizes across the world. Such studies have emerged in the last years as a new tool to improve the traditional, stationary based approach in flood frequency analysis and flood prediction. Here we seek to advance previous studies by evaluating the dominance of large scale processes (e.g. atmospheric rivers/moisture transport) over local processes (e.g. local convection) in producing floods. We consider flood-prone regions in Brazil as case studies and the role of large scale climate processes in generating extreme floods in such regions is explored by means of observed streamflow, reanalysis data and machine learning methods. The dynamics of the large scale atmospheric circulation in the days prior to the flood events are evaluated based on the vertically integrated moisture flux and its divergence field, which are interpreted in a low-dimensional space as obtained by machine learning techniques, particularly supervised kernel principal component analysis. In such reduced dimensional space, clusters are obtained in order to better understand the role of regional moisture recycling or teleconnected moisture in producing floods of a given magnitude. The convective available potential energy (CAPE) is also used as a measure of local convection activities. We investigate for individual sites the exceedance probability in which large scale atmospheric fluxes dominate the flood process. Finally, we analyze regional patterns of floods and how the scaling law of floods with drainage area responds to changes in the climate forcing mechanisms (e.g. local vs large scale).

  20. Effects of canine parvovirus strain variations on diagnostic test results and clinical management of enteritis in dogs.

    Science.gov (United States)

    Markovich, Jessica E; Stucker, Karla M; Carr, Alaina H; Harbison, Carole E; Scarlett, Janet M; Parrish, Colin R

    2012-07-01

    To estimate the prevalence of canine parvovirus (CPV) strains among dogs with enteritis admitted to a referral hospital in the southwestern United States during an 11-month period and to compare diagnostic test results, disease severity, and patient outcome among CPV strains. Prospective observational study. 72 dogs with histories and clinical signs of parvoviral enteritis. For each dog, a fecal sample or rectal swab specimen was evaluated for CPV antigen via an ELISA. Subsequently, fecal samples (n = 42 dogs) and pharyngeal swab specimens (16) were obtained and tested for CPV antigen via an ELISA and CPV DNA via a PCR assay. For specimens with CPV-positive results via PCR assay, genetic sequencing was performed to identify the CPV strain. 56 dogs tested positive for CPV via ELISA or PCR assay. For 42 fecal samples tested via both ELISA and PCR assay, 27 had positive results via both assays, whereas 6 had positive PCR assay results only. Ten pharyngeal swab specimens yielded positive PCR assay results. Genetic sequencing was performed on 34 fecal or pharyngeal swab specimens that had CPV-positive PCR assay results; 25 (73.5%) were identified as containing CPV type-2c, and 9 (26.5%) were identified as containing CPV type-2b. No association was found between CPV strain and disease severity or clinical outcome. CPV type-2b and CPV type-2c posed similar health risks for dogs; therefore, genetic sequencing of CPV does not appear necessary for clinical management of infected patients. The diagnostic tests used could detect CPV type-2c.

  1. Report of the LASCAR forum: Large scale reprocessing plant safeguards

    International Nuclear Information System (INIS)

    1992-01-01

    This report has been prepared to provide information on the studies which were carried out from 1988 to 1992 under the auspices of the multinational forum known as Large Scale Reprocessing Plant Safeguards (LASCAR) on safeguards for four large scale reprocessing plants operated or planned to be operated in the 1990s. The report summarizes all of the essential results of these studies. The participants in LASCAR were from France, Germany, Japan, the United Kingdom, the United States of America, the Commission of the European Communities - Euratom, and the International Atomic Energy Agency

  2. Large-scale structure observables in general relativity

    International Nuclear Information System (INIS)

    Jeong, Donghui; Schmidt, Fabian

    2015-01-01

    We review recent studies that rigorously define several key observables of the large-scale structure of the Universe in a general relativistic context. Specifically, we consider (i) redshift perturbation of cosmic clock events; (ii) distortion of cosmic rulers, including weak lensing shear and magnification; and (iii) observed number density of tracers of the large-scale structure. We provide covariant and gauge-invariant expressions of these observables. Our expressions are given for a linearly perturbed flat Friedmann–Robertson–Walker metric including scalar, vector, and tensor metric perturbations. While we restrict ourselves to linear order in perturbation theory, the approach can be straightforwardly generalized to higher order. (paper)

  3. Topology Optimization of Large Scale Stokes Flow Problems

    DEFF Research Database (Denmark)

    Aage, Niels; Poulsen, Thomas Harpsøe; Gersborg-Hansen, Allan

    2008-01-01

    This note considers topology optimization of large scale 2D and 3D Stokes flow problems using parallel computations. We solve problems with up to 1.125.000 elements in 2D and 128.000 elements in 3D on a shared memory computer consisting of Sun UltraSparc IV CPUs.......This note considers topology optimization of large scale 2D and 3D Stokes flow problems using parallel computations. We solve problems with up to 1.125.000 elements in 2D and 128.000 elements in 3D on a shared memory computer consisting of Sun UltraSparc IV CPUs....

  4. Fatigue Analysis of Large-scale Wind turbine

    Directory of Open Access Journals (Sweden)

    Zhu Yongli

    2017-01-01

    Full Text Available The paper does research on top flange fatigue damage of large-scale wind turbine generator. It establishes finite element model of top flange connection system with finite element analysis software MSC. Marc/Mentat, analyzes its fatigue strain, implements load simulation of flange fatigue working condition with Bladed software, acquires flange fatigue load spectrum with rain-flow counting method, finally, it realizes fatigue analysis of top flange with fatigue analysis software MSC. Fatigue and Palmgren-Miner linear cumulative damage theory. The analysis result indicates that its result provides new thinking for flange fatigue analysis of large-scale wind turbine generator, and possesses some practical engineering value.

  5. Generation of large-scale vortives in compressible helical turbulence

    International Nuclear Information System (INIS)

    Chkhetiani, O.G.; Gvaramadze, V.V.

    1989-01-01

    We consider generation of large-scale vortices in compressible self-gravitating turbulent medium. The closed equation describing evolution of the large-scale vortices in helical turbulence with finite correlation time is obtained. This equation has the form similar to the hydromagnetic dynamo equation, which allows us to call the vortx genertation effect the vortex dynamo. It is possible that principally the same mechanism is responsible both for amplification and maintenance of density waves and magnetic fields in gaseous disks of spiral galaxies. (author). 29 refs

  6. Enteric glia.

    Science.gov (United States)

    Rühl, A; Nasser, Y; Sharkey, K A

    2004-04-01

    The enteric nervous system is composed of both enteric neurones and enteric glia. Enteric glial cells were first described by Dogiel and are now known to outnumber neurones approximately 4 : 1. In the past, these cells were assumed to subserve a largely supportive role; however, recent evidence indicates that enteric glial cells may play a more active role in the control of gut function. In transgenic mouse models, where enteric glial cells are selectively ablated, the loss of glia results in intestinal inflammation and disruption of the epithelial barrier. Enteric glia are activated specifically by inflammatory insults and may contribute actively to inflammatory pathology via antigen presentation and cytokine synthesis. Enteric glia also express receptors for neurotransmitters and so may serve as intermediaries in enteric neurotransmission. Thus, enteric glia may serve as a link between the nervous and immune systems of the gut and may also have an important role in maintaining the integrity of the mucosal barrier and in other aspects of intestinal homeostasis.

  7. Clinical bioethics in china: the challenge of entering a market economy.

    Science.gov (United States)

    Chen, Xiao-Yang

    2006-02-01

    Over the last quarter-century, China has experienced dramatic changes associated with its development of a market economy. The character of clinical practice is also profoundly influenced by the ways in which reimbursement scales are established in public hospitals. The market distortions that lead to the over-prescription of drugs and the medically unindicated use of more expensive drugs and more costly high-technology diagnostic and therapeutic interventions create the most significant threat to patients. The payment of red packets represents a black-market attempt to circumvent the non-market constraint on physicians' fees for services. These economic and practice pattern changes are taking place as China and many Pacific Rim societies are reconsidering the moral foundations of their professional ethics and their bioethics. The integrity of the medical profession and the trust of patients in physicians can only be restored and protected if the distorting forces of contemporary public policy are altered.

  8. Nutritive utilization of protein and digestive utilization of fat in two commercial diets designed for clinical enteral nutrition.

    Science.gov (United States)

    Alférez, M J; Campos, M S; Barrionuevo, M; López-Aliaga, I

    1990-01-01

    The digestive and metabolic utilization of protein (50% lactoalbumin + 50% casein) and fat (43.0% butter, 29.5% olive oil, 14.7% soy oil, 9.8% MCT and 3.0% lecithin) provided by two commercial diets used in clinical enteral nutrition (normoproteic, 16.1% protein and 20.8% fat, and hyperproteic, 23.1% protein and 14.9% fat), was studied in adult rats (mean body weight 180 g). The diet containing the greater amount of protein improved the digestive utilization of nitrogen, and although nitrogen retention was optimal, it failed to rise further when the dietary protein supply was increased. The digestive utilization of fat in both diets was excellent.

  9. Large-scale Lurgi plant would be uneconomic: study group

    Energy Technology Data Exchange (ETDEWEB)

    1964-03-21

    Gas Council and National Coal Board agreed that building of large scale Lurgi plant on the basis of study is not at present acceptable on economic grounds. The committee considered that new processes based on naphtha offered more economic sources of base and peak load production. Tables listing data provided in contractors' design studies and summary of contractors' process designs are included.

  10. Origin of large-scale cell structure in the universe

    International Nuclear Information System (INIS)

    Zel'dovich, Y.B.

    1982-01-01

    A qualitative explanation is offered for the characteristic global structure of the universe, wherein ''black'' regions devoid of galaxies are surrounded on all sides by closed, comparatively thin, ''bright'' layers populated by galaxies. The interpretation rests on some very general arguments regarding the growth of large-scale perturbations in a cold gas

  11. Large-Scale Systems Control Design via LMI Optimization

    Czech Academy of Sciences Publication Activity Database

    Rehák, Branislav

    2015-01-01

    Roč. 44, č. 3 (2015), s. 247-253 ISSN 1392-124X Institutional support: RVO:67985556 Keywords : Combinatorial linear matrix inequalities * large-scale system * decentralized control Subject RIV: BC - Control Systems Theory Impact factor: 0.633, year: 2015

  12. Identification of low order models for large scale processes

    NARCIS (Netherlands)

    Wattamwar, S.K.

    2010-01-01

    Many industrial chemical processes are complex, multi-phase and large scale in nature. These processes are characterized by various nonlinear physiochemical effects and fluid flows. Such processes often show coexistence of fast and slow dynamics during their time evolutions. The increasing demand

  13. Worldwide large-scale fluctuations of sardine and anchovy ...

    African Journals Online (AJOL)

    Worldwide large-scale fluctuations of sardine and anchovy populations. ... African Journal of Marine Science. Journal Home · ABOUT THIS JOURNAL · Advanced ... Fullscreen Fullscreen Off. http://dx.doi.org/10.2989/AJMS.2008.30.1.13.463.

  14. Worldwide large-scale fluctuations of sardine and anchovy ...

    African Journals Online (AJOL)

    Worldwide large-scale fluctuations of sardine and anchovy populations. ... African Journal of Marine Science. Journal Home · ABOUT THIS JOURNAL · Advanced ... http://dx.doi.org/10.2989/AJMS.2008.30.1.13.463 · AJOL African Journals ...

  15. Large-scale coastal impact induced by a catastrophic storm

    DEFF Research Database (Denmark)

    Fruergaard, Mikkel; Andersen, Thorbjørn Joest; Johannessen, Peter N

    breaching. Our results demonstrate that violent, millennial-scale storms can trigger significant large-scale and long-term changes on barrier coasts, and that coastal changes assumed to take place over centuries or even millennia may occur in association with a single extreme storm event....

  16. Success Factors of Large Scale ERP Implementation in Thailand

    OpenAIRE

    Rotchanakitumnuai; Siriluck

    2010-01-01

    The objectives of the study are to examine the determinants of ERP implementation success factors of ERP implementation. The result indicates that large scale ERP implementation success consist of eight factors: project management competence, knowledge sharing, ERP system quality , understanding, user involvement, business process re-engineering, top management support, organization readiness.

  17. Planck intermediate results XLII. Large-scale Galactic magnetic fields

    DEFF Research Database (Denmark)

    Adam, R.; Ade, P. A. R.; Alves, M. I. R.

    2016-01-01

    Recent models for the large-scale Galactic magnetic fields in the literature have been largely constrained by synchrotron emission and Faraday rotation measures. We use three different but representative models to compare their predicted polarized synchrotron and dust emission with that measured ...

  18. Large Scale Simulations of the Euler Equations on GPU Clusters

    KAUST Repository

    Liebmann, Manfred; Douglas, Craig C.; Haase, Gundolf; Horvá th, Zoltá n

    2010-01-01

    The paper investigates the scalability of a parallel Euler solver, using the Vijayasundaram method, on a GPU cluster with 32 Nvidia Geforce GTX 295 boards. The aim of this research is to enable large scale fluid dynamics simulations with up to one

  19. Breakdown of large-scale circulation in turbulent rotating convection

    NARCIS (Netherlands)

    Kunnen, R.P.J.; Clercx, H.J.H.; Geurts, Bernardus J.

    2008-01-01

    Turbulent rotating convection in a cylinder is investigated both numerically and experimentally at Rayleigh number Ra = $10^9$ and Prandtl number $\\sigma$ = 6.4. In this Letter we discuss two topics: the breakdown under rotation of the domain-filling large-scale circulation (LSC) typical for

  20. Penalized Estimation in Large-Scale Generalized Linear Array Models

    DEFF Research Database (Denmark)

    Lund, Adam; Vincent, Martin; Hansen, Niels Richard

    2017-01-01

    Large-scale generalized linear array models (GLAMs) can be challenging to fit. Computation and storage of its tensor product design matrix can be impossible due to time and memory constraints, and previously considered design matrix free algorithms do not scale well with the dimension...

  1. A Chain Perspective on Large-scale Number Systems

    NARCIS (Netherlands)

    Grijpink, J.H.A.M.

    2012-01-01

    As large-scale number systems gain significance in social and economic life (electronic communication, remote electronic authentication), the correct functioning and the integrity of public number systems take on crucial importance. They are needed to uniquely indicate people, objects or phenomena

  2. Image-based Exploration of Large-Scale Pathline Fields

    KAUST Repository

    Nagoor, Omniah H.

    2014-01-01

    structure in which each pixel contains a list of pathlines segments. With this view-dependent method it is possible to filter, color-code and explore large-scale flow data in real-time. In addition, optimization techniques such as early-ray termination

  3. Temporal Variation of Large Scale Flows in the Solar Interior ...

    Indian Academy of Sciences (India)

    tribpo

    Temporal Variation of Large Scale Flows in the Solar Interior. 355. Figure 2. Zonal and meridional components of the time-dependent residual velocity at a few selected depths as marked above each panel, are plotted as contours of constant velocity in the longitude-latitude plane. The left panels show the zonal component, ...

  4. Facile Large-Scale Synthesis of 5- and 6-Carboxyfluoresceins

    DEFF Research Database (Denmark)

    Hammershøj, Peter; Ek, Pramod Kumar; Harris, Pernille

    2015-01-01

    A series of fluorescein dyes have been prepared from a common precursor through a very simple synthetic procedure, giving access to important precursors for fluorescent probes. The method has proven an efficient access to regioisomerically pure 5- and 6-carboxyfluoresceins on a large scale, in good...

  5. The Large-Scale Structure of Scientific Method

    Science.gov (United States)

    Kosso, Peter

    2009-01-01

    The standard textbook description of the nature of science describes the proposal, testing, and acceptance of a theoretical idea almost entirely in isolation from other theories. The resulting model of science is a kind of piecemeal empiricism that misses the important network structure of scientific knowledge. Only the large-scale description of…

  6. Newton Methods for Large Scale Problems in Machine Learning

    Science.gov (United States)

    Hansen, Samantha Leigh

    2014-01-01

    The focus of this thesis is on practical ways of designing optimization algorithms for minimizing large-scale nonlinear functions with applications in machine learning. Chapter 1 introduces the overarching ideas in the thesis. Chapters 2 and 3 are geared towards supervised machine learning applications that involve minimizing a sum of loss…

  7. Large-Scale Machine Learning for Classification and Search

    Science.gov (United States)

    Liu, Wei

    2012-01-01

    With the rapid development of the Internet, nowadays tremendous amounts of data including images and videos, up to millions or billions, can be collected for training machine learning models. Inspired by this trend, this thesis is dedicated to developing large-scale machine learning techniques for the purpose of making classification and nearest…

  8. Large scale solar district heating. Evaluation, modelling and designing - Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Heller, A.

    2000-07-01

    The appendices present the following: A) Cad-drawing of the Marstal CSHP design. B) Key values - large-scale solar heating in Denmark. C) Monitoring - a system description. D) WMO-classification of pyranometers (solarimeters). E) The computer simulation model in TRNSYS. F) Selected papers from the author. (EHS)

  9. Proceedings of the meeting on large scale computer simulation research

    International Nuclear Information System (INIS)

    2004-04-01

    The meeting to summarize the collaboration activities for FY2003 on the Large Scale Computer Simulation Research was held January 15-16, 2004 at Theory and Computer Simulation Research Center, National Institute for Fusion Science. Recent simulation results, methodologies and other related topics were presented. (author)

  10. Chirping for large-scale maritime archaeological survey

    DEFF Research Database (Denmark)

    Grøn, Ole; Boldreel, Lars Ole

    2014-01-01

    Archaeological wrecks exposed on the sea floor are mapped using side-scan and multibeam techniques, whereas the detection of submerged archaeological sites, such as Stone Age settlements, and wrecks, partially or wholly embedded in sea-floor sediments, requires the application of high-resolution ...... the present state of this technology, it appears well suited to large-scale maritime archaeological mapping....

  11. Large-scale Homogenization of Bulk Materials in Mammoth Silos

    NARCIS (Netherlands)

    Schott, D.L.

    2004-01-01

    This doctoral thesis concerns the large-scale homogenization of bulk materials in mammoth silos. The objective of this research was to determine the best stacking and reclaiming method for homogenization in mammoth silos. For this purpose a simulation program was developed to estimate the

  12. Large Scale Survey Data in Career Development Research

    Science.gov (United States)

    Diemer, Matthew A.

    2008-01-01

    Large scale survey datasets have been underutilized but offer numerous advantages for career development scholars, as they contain numerous career development constructs with large and diverse samples that are followed longitudinally. Constructs such as work salience, vocational expectations, educational expectations, work satisfaction, and…

  13. Large Scale Anomalies of the Cosmic Microwave Background with Planck

    DEFF Research Database (Denmark)

    Frejsel, Anne Mette

    This thesis focuses on the large scale anomalies of the Cosmic Microwave Background (CMB) and their possible origins. The investigations consist of two main parts. The first part is on statistical tests of the CMB, and the consistency of both maps and power spectrum. We find that the Planck data...

  14. Fractals and the Large-Scale Structure in the Universe

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 4. Fractals and the Large-Scale Structure in the Universe - Is the Cosmological Principle Valid? A K Mittal T R Seshadri. General Article Volume 7 Issue 4 April 2002 pp 39-47 ...

  15. LARGE-SCALE COMMERCIAL INVESTMENTS IN LAND: SEEKING ...

    African Journals Online (AJOL)

    extent of large-scale investment in land or to assess its impact on the people in recipient countries. .... favorable lease terms, apparently based on a belief that this is necessary to .... Harm to the rights of local occupiers of land can result from a dearth. 24. ..... applies to a self-identified group based on the group's traditions.

  16. Mixing Metaphors: Building Infrastructure for Large Scale School Turnaround

    Science.gov (United States)

    Peurach, Donald J.; Neumerski, Christine M.

    2015-01-01

    The purpose of this analysis is to increase understanding of the possibilities and challenges of building educational infrastructure--the basic, foundational structures, systems, and resources--to support large-scale school turnaround. Building educational infrastructure often exceeds the capacity of schools, districts, and state education…

  17. Reconsidering Replication: New Perspectives on Large-Scale School Improvement

    Science.gov (United States)

    Peurach, Donald J.; Glazer, Joshua L.

    2012-01-01

    The purpose of this analysis is to reconsider organizational replication as a strategy for large-scale school improvement: a strategy that features a "hub" organization collaborating with "outlet" schools to enact school-wide designs for improvement. To do so, we synthesize a leading line of research on commercial replication to construct a…

  18. First Mile Challenges for Large-Scale IoT

    KAUST Repository

    Bader, Ahmed; Elsawy, Hesham; Gharbieh, Mohammad; Alouini, Mohamed-Slim; Adinoyi, Abdulkareem; Alshaalan, Furaih

    2017-01-01

    The Internet of Things is large-scale by nature. This is not only manifested by the large number of connected devices, but also by the sheer scale of spatial traffic intensity that must be accommodated, primarily in the uplink direction. To that end

  19. VESPA: Very large-scale Evolutionary and Selective Pressure Analyses

    Directory of Open Access Journals (Sweden)

    Andrew E. Webb

    2017-06-01

    Full Text Available Background Large-scale molecular evolutionary analyses of protein coding sequences requires a number of preparatory inter-related steps from finding gene families, to generating alignments and phylogenetic trees and assessing selective pressure variation. Each phase of these analyses can represent significant challenges, particularly when working with entire proteomes (all protein coding sequences in a genome from a large number of species. Methods We present VESPA, software capable of automating a selective pressure analysis using codeML in addition to the preparatory analyses and summary statistics. VESPA is written in python and Perl and is designed to run within a UNIX environment. Results We have benchmarked VESPA and our results show that the method is consistent, performs well on both large scale and smaller scale datasets, and produces results in line with previously published datasets. Discussion Large-scale gene family identification, sequence alignment, and phylogeny reconstruction are all important aspects of large-scale molecular evolutionary analyses. VESPA provides flexible software for simplifying these processes along with downstream selective pressure variation analyses. The software automatically interprets results from codeML and produces simplified summary files to assist the user in better understanding the results. VESPA may be found at the following website: http://www.mol-evol.org/VESPA.

  20. Technologies and challenges in large-scale phosphoproteomics

    DEFF Research Database (Denmark)

    Engholm-Keller, Kasper; Larsen, Martin Røssel

    2013-01-01

    become the main technique for discovery and characterization of phosphoproteins in a nonhypothesis driven fashion. In this review, we describe methods for state-of-the-art MS-based analysis of protein phosphorylation as well as the strategies employed in large-scale phosphoproteomic experiments...... with focus on the various challenges and limitations this field currently faces....

  1. Solving Large Scale Crew Scheduling Problems in Practice

    NARCIS (Netherlands)

    E.J.W. Abbink (Erwin); L. Albino; T.A.B. Dollevoet (Twan); D. Huisman (Dennis); J. Roussado; R.L. Saldanha

    2010-01-01

    textabstractThis paper deals with large-scale crew scheduling problems arising at the Dutch railway operator, Netherlands Railways (NS). NS operates about 30,000 trains a week. All these trains need a driver and a certain number of guards. Some labor rules restrict the duties of a certain crew base

  2. The large scale microwave background anisotropy in decaying particle cosmology

    International Nuclear Information System (INIS)

    Panek, M.

    1987-06-01

    We investigate the large-scale anisotropy of the microwave background radiation in cosmological models with decaying particles. The observed value of the quadrupole moment combined with other constraints gives an upper limit on the redshift of the decay z/sub d/ < 3-5. 12 refs., 2 figs

  3. Dual Decomposition for Large-Scale Power Balancing

    DEFF Research Database (Denmark)

    Halvgaard, Rasmus; Jørgensen, John Bagterp; Vandenberghe, Lieven

    2013-01-01

    Dual decomposition is applied to power balancing of exible thermal storage units. The centralized large-scale problem is decomposed into smaller subproblems and solved locallyby each unit in the Smart Grid. Convergence is achieved by coordinating the units consumption through a negotiation...

  4. Evaluation of Large-scale Public Sector Reforms

    DEFF Research Database (Denmark)

    Breidahl, Karen Nielsen; Gjelstrup, Gunnar; Hansen, Hanne Foss

    2017-01-01

    and more delimited policy areas take place. In our analysis we apply four governance perspectives (rational-instrumental, rational-interest based, institutional-cultural and a chaos perspective) in a comparative analysis of the evaluations of two large-scale public sector reforms in Denmark and Norway. We...

  5. Assessment of climate change impacts on rainfall using large scale ...

    Indian Academy of Sciences (India)

    Many of the applied techniques in water resources management can be directly or indirectly influenced by ... is based on large scale climate signals data around the world. In order ... predictand relationships are often very complex. .... constraints to solve the optimization problem. ..... social, and environmental sustainability.

  6. Factors Influencing Uptake of a Large Scale Curriculum Innovation.

    Science.gov (United States)

    Adey, Philip S.

    Educational research has all too often failed to be implemented on a large-scale basis. This paper describes the multiplier effect of a professional development program for teachers and for trainers in the United Kingdom, and how that program was developed, monitored, and evaluated. Cognitive Acceleration through Science Education (CASE) is a…

  7. ability in Large Scale Land Acquisitions in Kenya

    International Development Research Centre (IDRC) Digital Library (Canada)

    Corey Piccioni

    Kenya's national planning strategy, Vision 2030. Agri- culture, natural resource exploitation, and infrastruc- ... sitions due to high levels of poverty and unclear or in- secure land tenure rights in Kenya. Inadequate social ... lease to a private company over the expansive Yala. Swamp to undertake large-scale irrigation farming.

  8. New Visions for Large Scale Networks: Research and Applications

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — This paper documents the findings of the March 12-14, 2001 Workshop on New Visions for Large-Scale Networks: Research and Applications. The workshops objectives were...

  9. Large-scale silviculture experiments of western Oregon and Washington.

    Science.gov (United States)

    Nathan J. Poage; Paul D. Anderson

    2007-01-01

    We review 12 large-scale silviculture experiments (LSSEs) in western Washington and Oregon with which the Pacific Northwest Research Station of the USDA Forest Service is substantially involved. We compiled and arrayed information about the LSSEs as a series of matrices in a relational database, which is included on the compact disc published with this report and...

  10. Participatory Design and the Challenges of Large-Scale Systems

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2008-01-01

    With its 10th biannual anniversary conference, Participatory Design (PD) is leaving its teens and must now be considered ready to join the adult world. In this article we encourage the PD community to think big: PD should engage in large-scale information-systems development and opt for a PD...

  11. Women entering clinical psychology: Q-sort narratives of career attraction of female clinical psychology trainees in the UK.

    Science.gov (United States)

    Baker, Martyn; Nash, Jen

    2013-01-01

    The great majority of the UK clinical psychology workforce are women, and this fact prompted an examination of the various ways clinical psychology might be seen as attractive to women--a neglected research topic. Female clinical psychology trainees from a variety of training programmes Q-sorted statements of potential job attractors. The process of analysis is outlined before most of the article is devoted to explicating the five narratives of attraction generated: making a difference, waiting for what I want, idealising challenge, identifying with distress and acknowledging power and privilege. Two super-ordinate 'stories' spanning the narratives are suggested--an over-riding attraction to the profession and a rebuttal of the suggestion that this attraction may be based on any overtly gendered grounds. In the absence of previous empirical data of women's attraction to clinical psychology, the small but significant contribution to understanding the profession made by the analysis is acknowledged--as is the need for further research to confirm and develop the findings. Copyright © 2011 John Wiley & Sons, Ltd.

  12. GAIA: A WINDOW TO LARGE-SCALE MOTIONS

    Energy Technology Data Exchange (ETDEWEB)

    Nusser, Adi [Physics Department and the Asher Space Science Institute-Technion, Haifa 32000 (Israel); Branchini, Enzo [Department of Physics, Universita Roma Tre, Via della Vasca Navale 84, 00146 Rome (Italy); Davis, Marc, E-mail: adi@physics.technion.ac.il, E-mail: branchin@fis.uniroma3.it, E-mail: mdavis@berkeley.edu [Departments of Astronomy and Physics, University of California, Berkeley, CA 94720 (United States)

    2012-08-10

    Using redshifts as a proxy for galaxy distances, estimates of the two-dimensional (2D) transverse peculiar velocities of distant galaxies could be obtained from future measurements of proper motions. We provide the mathematical framework for analyzing 2D transverse motions and show that they offer several advantages over traditional probes of large-scale motions. They are completely independent of any intrinsic relations between galaxy properties; hence, they are essentially free of selection biases. They are free from homogeneous and inhomogeneous Malmquist biases that typically plague distance indicator catalogs. They provide additional information to traditional probes that yield line-of-sight peculiar velocities only. Further, because of their 2D nature, fundamental questions regarding vorticity of large-scale flows can be addressed. Gaia, for example, is expected to provide proper motions of at least bright galaxies with high central surface brightness, making proper motions a likely contender for traditional probes based on current and future distance indicator measurements.

  13. Large-scale innovation and change in UK higher education

    Directory of Open Access Journals (Sweden)

    Stephen Brown

    2013-09-01

    Full Text Available This paper reflects on challenges universities face as they respond to change. It reviews current theories and models of change management, discusses why universities are particularly difficult environments in which to achieve large scale, lasting change and reports on a recent attempt by the UK JISC to enable a range of UK universities to employ technology to deliver such changes. Key lessons that emerged from these experiences are reviewed covering themes of pervasiveness, unofficial systems, project creep, opposition, pressure to deliver, personnel changes and technology issues. The paper argues that collaborative approaches to project management offer greater prospects of effective large-scale change in universities than either management-driven top-down or more champion-led bottom-up methods. It also argues that while some diminution of control over project outcomes is inherent in this approach, this is outweighed by potential benefits of lasting and widespread adoption of agreed changes.

  14. Measuring Cosmic Expansion and Large Scale Structure with Destiny

    Science.gov (United States)

    Benford, Dominic J.; Lauer, Tod R.

    2007-01-01

    Destiny is a simple, direct, low cost mission to determine the properties of dark energy by obtaining a cosmologically deep supernova (SN) type Ia Hubble diagram and by measuring the large-scale mass power spectrum over time. Its science instrument is a 1.65m space telescope, featuring a near-infrared survey camera/spectrometer with a large field of view. During its first two years, Destiny will detect, observe, and characterize 23000 SN Ia events over the redshift interval 0.4Destiny will be used in its third year as a high resolution, wide-field imager to conduct a weak lensing survey covering >lo00 square degrees to measure the large-scale mass power spectrum. The combination of surveys is much more powerful than either technique on its own, and will have over an order of magnitude greater sensitivity than will be provided by ongoing ground-based projects.

  15. Volume measurement study for large scale input accountancy tank

    International Nuclear Information System (INIS)

    Uchikoshi, Seiji; Watanabe, Yuichi; Tsujino, Takeshi

    1999-01-01

    Large Scale Tank Calibration (LASTAC) facility, including an experimental tank which has the same volume and structure as the input accountancy tank of Rokkasho Reprocessing Plant (RRP) was constructed in Nuclear Material Control Center of Japan. Demonstration experiments have been carried out to evaluate a precision of solution volume measurement and to establish the procedure of highly accurate pressure measurement for a large scale tank with dip-tube bubbler probe system to be applied to the input accountancy tank of RRP. Solution volume in a tank is determined from substitution the solution level for the calibration function obtained in advance, which express a relation between the solution level and its volume in the tank. Therefore, precise solution volume measurement needs a precise calibration function that is determined carefully. The LASTAC calibration experiments using pure water showed good result in reproducibility. (J.P.N.)

  16. Prototype Vector Machine for Large Scale Semi-Supervised Learning

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Kai; Kwok, James T.; Parvin, Bahram

    2009-04-29

    Practicaldataminingrarelyfalls exactlyinto the supervisedlearning scenario. Rather, the growing amount of unlabeled data poses a big challenge to large-scale semi-supervised learning (SSL). We note that the computationalintensivenessofgraph-based SSLarises largely from the manifold or graph regularization, which in turn lead to large models that are dificult to handle. To alleviate this, we proposed the prototype vector machine (PVM), a highlyscalable,graph-based algorithm for large-scale SSL. Our key innovation is the use of"prototypes vectors" for effcient approximation on both the graph-based regularizer and model representation. The choice of prototypes are grounded upon two important criteria: they not only perform effective low-rank approximation of the kernel matrix, but also span a model suffering the minimum information loss compared with the complete model. We demonstrate encouraging performance and appealing scaling properties of the PVM on a number of machine learning benchmark data sets.

  17. Large-scale influences in near-wall turbulence.

    Science.gov (United States)

    Hutchins, Nicholas; Marusic, Ivan

    2007-03-15

    Hot-wire data acquired in a high Reynolds number facility are used to illustrate the need for adequate scale separation when considering the coherent structure in wall-bounded turbulence. It is found that a large-scale motion in the log region becomes increasingly comparable in energy to the near-wall cycle as the Reynolds number increases. Through decomposition of fluctuating velocity signals, it is shown that this large-scale motion has a distinct modulating influence on the small-scale energy (akin to amplitude modulation). Reassessment of DNS data, in light of these results, shows similar trends, with the rate and intensity of production due to the near-wall cycle subject to a modulating influence from the largest-scale motions.

  18. First Mile Challenges for Large-Scale IoT

    KAUST Repository

    Bader, Ahmed

    2017-03-16

    The Internet of Things is large-scale by nature. This is not only manifested by the large number of connected devices, but also by the sheer scale of spatial traffic intensity that must be accommodated, primarily in the uplink direction. To that end, cellular networks are indeed a strong first mile candidate to accommodate the data tsunami to be generated by the IoT. However, IoT devices are required in the cellular paradigm to undergo random access procedures as a precursor to resource allocation. Such procedures impose a major bottleneck that hinders cellular networks\\' ability to support large-scale IoT. In this article, we shed light on the random access dilemma and present a case study based on experimental data as well as system-level simulations. Accordingly, a case is built for the latent need to revisit random access procedures. A call for action is motivated by listing a few potential remedies and recommendations.

  19. Cosmic ray acceleration by large scale galactic shocks

    International Nuclear Information System (INIS)

    Cesarsky, C.J.; Lagage, P.O.

    1987-01-01

    The mechanism of diffusive shock acceleration may account for the existence of galactic cosmic rays detailed application to stellar wind shocks and especially to supernova shocks have been developed. Existing models can usually deal with the energetics or the spectral slope, but the observed energy range of cosmic rays is not explained. Therefore it seems worthwhile to examine the effect that large scale, long-lived galactic shocks may have on galactic cosmic rays, in the frame of the diffusive shock acceleration mechanism. Large scale fast shocks can only be expected to exist in the galactic halo. We consider three situations where they may arise: expansion of a supernova shock in the halo, galactic wind, galactic infall; and discuss the possible existence of these shocks and their role in accelerating cosmic rays

  20. Efficient algorithms for collaborative decision making for large scale settings

    DEFF Research Database (Denmark)

    Assent, Ira

    2011-01-01

    to bring about more effective and more efficient retrieval systems that support the users' decision making process. We sketch promising research directions for more efficient algorithms for collaborative decision making, especially for large scale systems.......Collaborative decision making is a successful approach in settings where data analysis and querying can be done interactively. In large scale systems with huge data volumes or many users, collaboration is often hindered by impractical runtimes. Existing work on improving collaboration focuses...... on avoiding redundancy for users working on the same task. While this improves the effectiveness of the user work process, the underlying query processing engine is typically considered a "black box" and left unchanged. Research in multiple query processing, on the other hand, ignores the application...

  1. Lagrangian space consistency relation for large scale structure

    International Nuclear Information System (INIS)

    Horn, Bart; Hui, Lam; Xiao, Xiao

    2015-01-01

    Consistency relations, which relate the squeezed limit of an (N+1)-point correlation function to an N-point function, are non-perturbative symmetry statements that hold even if the associated high momentum modes are deep in the nonlinear regime and astrophysically complex. Recently, Kehagias and Riotto and Peloso and Pietroni discovered a consistency relation applicable to large scale structure. We show that this can be recast into a simple physical statement in Lagrangian space: that the squeezed correlation function (suitably normalized) vanishes. This holds regardless of whether the correlation observables are at the same time or not, and regardless of whether multiple-streaming is present. The simplicity of this statement suggests that an analytic understanding of large scale structure in the nonlinear regime may be particularly promising in Lagrangian space

  2. The Large-scale Effect of Environment on Galactic Conformity

    Science.gov (United States)

    Sun, Shuangpeng; Guo, Qi; Wang, Lan; Wang, Jie; Gao, Liang; Lacey, Cedric G.; Pan, Jun

    2018-04-01

    We use a volume-limited galaxy sample from the SDSS Data Release 7 to explore the dependence of galactic conformity on the large-scale environment, measured on ˜ 4 Mpc scales. We find that the star formation activity of neighbour galaxies depends more strongly on the environment than on the activity of their primary galaxies. In under-dense regions most neighbour galaxies tend to be active, while in over-dense regions neighbour galaxies are mostly passive, regardless of the activity of their primary galaxies. At a given stellar mass, passive primary galaxies reside in higher density regions than active primary galaxies, leading to the apparently strong conformity signal. The dependence of the activity of neighbour galaxies on environment can be explained by the corresponding dependence of the fraction of satellite galaxies. Similar results are found for galaxies in a semi-analytical model, suggesting that no new physics is required to explain the observed large-scale conformity.

  3. Electron drift in a large scale solid xenon

    International Nuclear Information System (INIS)

    Yoo, J.; Jaskierny, W.F.

    2015-01-01

    A study of charge drift in a large scale optically transparent solid xenon is reported. A pulsed high power xenon light source is used to liberate electrons from a photocathode. The drift speeds of the electrons are measured using a 8.7 cm long electrode in both the liquid and solid phase of xenon. In the liquid phase (163 K), the drift speed is 0.193 ± 0.003 cm/μs while the drift speed in the solid phase (157 K) is 0.397 ± 0.006 cm/μs at 900 V/cm over 8.0 cm of uniform electric fields. Therefore, it is demonstrated that a factor two faster electron drift speed in solid phase xenon compared to that in liquid in a large scale solid xenon

  4. Active power reserves evaluation in large scale PVPPs

    DEFF Research Database (Denmark)

    Crăciun, Bogdan-Ionut; Kerekes, Tamas; Sera, Dezso

    2013-01-01

    The present trend on investing in renewable ways of producing electricity in the detriment of conventional fossil fuel-based plants will lead to a certain point where these plants have to provide ancillary services and contribute to overall grid stability. Photovoltaic (PV) power has the fastest...... growth among all renewable energies and managed to reach high penetration levels creating instabilities which at the moment are corrected by the conventional generation. This paradigm will change in the future scenarios where most of the power is supplied by large scale renewable plants and parts...... of the ancillary services have to be shared by the renewable plants. The main focus of the proposed paper is to technically and economically analyze the possibility of having active power reserves in large scale PV power plants (PVPPs) without any auxiliary storage equipment. The provided reserves should...

  5. Real-time simulation of large-scale floods

    Science.gov (United States)

    Liu, Q.; Qin, Y.; Li, G. D.; Liu, Z.; Cheng, D. J.; Zhao, Y. H.

    2016-08-01

    According to the complex real-time water situation, the real-time simulation of large-scale floods is very important for flood prevention practice. Model robustness and running efficiency are two critical factors in successful real-time flood simulation. This paper proposed a robust, two-dimensional, shallow water model based on the unstructured Godunov- type finite volume method. A robust wet/dry front method is used to enhance the numerical stability. An adaptive method is proposed to improve the running efficiency. The proposed model is used for large-scale flood simulation on real topography. Results compared to those of MIKE21 show the strong performance of the proposed model.

  6. Some Statistics for Measuring Large-Scale Structure

    OpenAIRE

    Brandenberger, Robert H.; Kaplan, David M.; A, Stephen; Ramsey

    1993-01-01

    Good statistics for measuring large-scale structure in the Universe must be able to distinguish between different models of structure formation. In this paper, two and three dimensional ``counts in cell" statistics and a new ``discrete genus statistic" are applied to toy versions of several popular theories of structure formation: random phase cold dark matter model, cosmic string models, and global texture scenario. All three statistics appear quite promising in terms of differentiating betw...

  7. Foundations of Large-Scale Multimedia Information Management and Retrieval

    CERN Document Server

    Chang, Edward Y

    2011-01-01

    "Foundations of Large-Scale Multimedia Information Management and Retrieval - Mathematics of Perception" covers knowledge representation and semantic analysis of multimedia data and scalability in signal extraction, data mining, and indexing. The book is divided into two parts: Part I - Knowledge Representation and Semantic Analysis focuses on the key components of mathematics of perception as it applies to data management and retrieval. These include feature selection/reduction, knowledge representation, semantic analysis, distance function formulation for measuring similarity, and

  8. PKI security in large-scale healthcare networks

    OpenAIRE

    Mantas, G.; Lymberopoulos, D.; Komninos, N.

    2012-01-01

    During the past few years a lot of PKI (Public Key Infrastructures) infrastructures have been proposed for healthcare networks in order to ensure secure communication services and exchange of data among healthcare professionals. However, there is a plethora of challenges in these healthcare PKI infrastructures. Especially, there are a lot of challenges for PKI infrastructures deployed over large-scale healthcare networks. In this paper, we propose a PKI infrastructure to ensure security in a ...

  9. Experimental simulation of microinteractions in large scale explosions

    Energy Technology Data Exchange (ETDEWEB)

    Chen, X.; Luo, R.; Yuen, W.W.; Theofanous, T.G. [California Univ., Santa Barbara, CA (United States). Center for Risk Studies and Safety

    1998-01-01

    This paper presents data and analysis of recent experiments conducted in the SIGMA-2000 facility to simulate microinteractions in large scale explosions. Specifically, the fragmentation behavior of a high temperature molten steel drop under high pressure (beyond critical) conditions are investigated. The current data demonstrate, for the first time, the effect of high pressure in suppressing the thermal effect of fragmentation under supercritical conditions. The results support the microinteractions idea, and the ESPROSE.m prediction of fragmentation rate. (author)

  10. Large-scale motions in the universe: a review

    International Nuclear Information System (INIS)

    Burstein, D.

    1990-01-01

    The expansion of the universe can be retarded in localised regions within the universe both by the presence of gravity and by non-gravitational motions generated in the post-recombination universe. The motions of galaxies thus generated are called 'peculiar motions', and the amplitudes, size scales and coherence of these peculiar motions are among the most direct records of the structure of the universe. As such, measurements of these properties of the present-day universe provide some of the severest tests of cosmological theories. This is a review of the current evidence for large-scale motions of galaxies out to a distance of ∼5000 km s -1 (in an expanding universe, distance is proportional to radial velocity). 'Large-scale' in this context refers to motions that are correlated over size scales larger than the typical sizes of groups of galaxies, up to and including the size of the volume surveyed. To orient the reader into this relatively new field of study, a short modern history is given together with an explanation of the terminology. Careful consideration is given to the data used to measure the distances, and hence the peculiar motions, of galaxies. The evidence for large-scale motions is presented in a graphical fashion, using only the most reliable data for galaxies spanning a wide range in optical properties and over the complete range of galactic environments. The kinds of systematic errors that can affect this analysis are discussed, and the reliability of these motions is assessed. The predictions of two models of large-scale motion are compared to the observations, and special emphasis is placed on those motions in which our own Galaxy directly partakes. (author)

  11. A Classification Framework for Large-Scale Face Recognition Systems

    OpenAIRE

    Zhou, Ziheng; Deravi, Farzin

    2009-01-01

    This paper presents a generic classification framework for large-scale face recognition systems. Within the framework, a data sampling strategy is proposed to tackle the data imbalance when image pairs are sampled from thousands of face images for preparing a training dataset. A modified kernel Fisher discriminant classifier is proposed to make it computationally feasible to train the kernel-based classification method using tens of thousands of training samples. The framework is tested in an...

  12. Large Scale Visual Recommendations From Street Fashion Images

    OpenAIRE

    Jagadeesh, Vignesh; Piramuthu, Robinson; Bhardwaj, Anurag; Di, Wei; Sundaresan, Neel

    2014-01-01

    We describe a completely automated large scale visual recommendation system for fashion. Our focus is to efficiently harness the availability of large quantities of online fashion images and their rich meta-data. Specifically, we propose four data driven models in the form of Complementary Nearest Neighbor Consensus, Gaussian Mixture Models, Texture Agnostic Retrieval and Markov Chain LDA for solving this problem. We analyze relative merits and pitfalls of these algorithms through extensive e...

  13. Design study on sodium cooled large-scale reactor

    International Nuclear Information System (INIS)

    Murakami, Tsutomu; Hishida, Masahiko; Kisohara, Naoyuki

    2004-07-01

    In Phase 1 of the 'Feasibility Studies on Commercialized Fast Reactor Cycle Systems (F/S)', an advanced loop type reactor has been selected as a promising concept of sodium-cooled large-scale reactor, which has a possibility to fulfill the design requirements of the F/S. In Phase 2, design improvement for further cost reduction of establishment of the plant concept has been performed. This report summarizes the results of the design study on the sodium-cooled large-scale reactor performed in JFY2003, which is the third year of Phase 2. In the JFY2003 design study, critical subjects related to safety, structural integrity and thermal hydraulics which found in the last fiscal year has been examined and the plant concept has been modified. Furthermore, fundamental specifications of main systems and components have been set and economy has been evaluated. In addition, as the interim evaluation of the candidate concept of the FBR fuel cycle is to be conducted, cost effectiveness and achievability for the development goal were evaluated and the data of the three large-scale reactor candidate concepts were prepared. As a results of this study, the plant concept of the sodium-cooled large-scale reactor has been constructed, which has a prospect to satisfy the economic goal (construction cost: less than 200,000 yens/kWe, etc.) and has a prospect to solve the critical subjects. From now on, reflecting the results of elemental experiments, the preliminary conceptual design of this plant will be preceded toward the selection for narrowing down candidate concepts at the end of Phase 2. (author)

  14. Design study on sodium-cooled large-scale reactor

    International Nuclear Information System (INIS)

    Shimakawa, Yoshio; Nibe, Nobuaki; Hori, Toru

    2002-05-01

    In Phase 1 of the 'Feasibility Study on Commercialized Fast Reactor Cycle Systems (F/S)', an advanced loop type reactor has been selected as a promising concept of sodium-cooled large-scale reactor, which has a possibility to fulfill the design requirements of the F/S. In Phase 2 of the F/S, it is planed to precede a preliminary conceptual design of a sodium-cooled large-scale reactor based on the design of the advanced loop type reactor. Through the design study, it is intended to construct such a plant concept that can show its attraction and competitiveness as a commercialized reactor. This report summarizes the results of the design study on the sodium-cooled large-scale reactor performed in JFY2001, which is the first year of Phase 2. In the JFY2001 design study, a plant concept has been constructed based on the design of the advanced loop type reactor, and fundamental specifications of main systems and components have been set. Furthermore, critical subjects related to safety, structural integrity, thermal hydraulics, operability, maintainability and economy have been examined and evaluated. As a result of this study, the plant concept of the sodium-cooled large-scale reactor has been constructed, which has a prospect to satisfy the economic goal (construction cost: less than 200,000yens/kWe, etc.) and has a prospect to solve the critical subjects. From now on, reflecting the results of elemental experiments, the preliminary conceptual design of this plant will be preceded toward the selection for narrowing down candidate concepts at the end of Phase 2. (author)

  15. Large-Scale Optimization for Bayesian Inference in Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Willcox, Karen [MIT; Marzouk, Youssef [MIT

    2013-11-12

    The SAGUARO (Scalable Algorithms for Groundwater Uncertainty Analysis and Robust Optimization) Project focused on the development of scalable numerical algorithms for large-scale Bayesian inversion in complex systems that capitalize on advances in large-scale simulation-based optimization and inversion methods. The project was a collaborative effort among MIT, the University of Texas at Austin, Georgia Institute of Technology, and Sandia National Laboratories. The research was directed in three complementary areas: efficient approximations of the Hessian operator, reductions in complexity of forward simulations via stochastic spectral approximations and model reduction, and employing large-scale optimization concepts to accelerate sampling. The MIT--Sandia component of the SAGUARO Project addressed the intractability of conventional sampling methods for large-scale statistical inverse problems by devising reduced-order models that are faithful to the full-order model over a wide range of parameter values; sampling then employs the reduced model rather than the full model, resulting in very large computational savings. Results indicate little effect on the computed posterior distribution. On the other hand, in the Texas--Georgia Tech component of the project, we retain the full-order model, but exploit inverse problem structure (adjoint-based gradients and partial Hessian information of the parameter-to-observation map) to implicitly extract lower dimensional information on the posterior distribution; this greatly speeds up sampling methods, so that fewer sampling points are needed. We can think of these two approaches as ``reduce then sample'' and ``sample then reduce.'' In fact, these two approaches are complementary, and can be used in conjunction with each other. Moreover, they both exploit deterministic inverse problem structure, in the form of adjoint-based gradient and Hessian information of the underlying parameter-to-observation map, to

  16. NASA: Assessments of Selected Large-Scale Projects

    Science.gov (United States)

    2011-03-01

    REPORT DATE MAR 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Assessments Of Selected Large-Scale Projects...Volatile EvolutioN MEP Mars Exploration Program MIB Mishap Investigation Board MMRTG Multi Mission Radioisotope Thermoelectric Generator MMS Magnetospheric...probes designed to explore the Martian surface, to satellites equipped with advanced sensors to study the earth , to telescopes intended to explore the

  17. Perturbation theory instead of large scale shell model calculations

    International Nuclear Information System (INIS)

    Feldmeier, H.; Mankos, P.

    1977-01-01

    Results of large scale shell model calculations for (sd)-shell nuclei are compared with a perturbation theory provides an excellent approximation when the SU(3)-basis is used as a starting point. The results indicate that perturbation theory treatment in an SU(3)-basis including 2hω excitations should be preferable to a full diagonalization within the (sd)-shell. (orig.) [de

  18. Primordial large-scale electromagnetic fields from gravitoelectromagnetic inflation

    Energy Technology Data Exchange (ETDEWEB)

    Membiela, Federico Agustin [Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, (7600) Mar del Plata (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina)], E-mail: membiela@mdp.edu.ar; Bellini, Mauricio [Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, (7600) Mar del Plata (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina)], E-mail: mbellini@mdp.edu.ar

    2009-04-20

    We investigate the origin and evolution of primordial electric and magnetic fields in the early universe, when the expansion is governed by a cosmological constant {lambda}{sub 0}. Using the gravitoelectromagnetic inflationary formalism with A{sub 0}=0, we obtain the power of spectrums for large-scale magnetic fields and the inflaton field fluctuations during inflation. A very important fact is that our formalism is naturally non-conformally invariant.

  19. Primordial large-scale electromagnetic fields from gravitoelectromagnetic inflation

    Science.gov (United States)

    Membiela, Federico Agustín; Bellini, Mauricio

    2009-04-01

    We investigate the origin and evolution of primordial electric and magnetic fields in the early universe, when the expansion is governed by a cosmological constant Λ0. Using the gravitoelectromagnetic inflationary formalism with A0 = 0, we obtain the power of spectrums for large-scale magnetic fields and the inflaton field fluctuations during inflation. A very important fact is that our formalism is naturally non-conformally invariant.

  20. Primordial large-scale electromagnetic fields from gravitoelectromagnetic inflation

    International Nuclear Information System (INIS)

    Membiela, Federico Agustin; Bellini, Mauricio

    2009-01-01

    We investigate the origin and evolution of primordial electric and magnetic fields in the early universe, when the expansion is governed by a cosmological constant Λ 0 . Using the gravitoelectromagnetic inflationary formalism with A 0 =0, we obtain the power of spectrums for large-scale magnetic fields and the inflaton field fluctuations during inflation. A very important fact is that our formalism is naturally non-conformally invariant.

  1. Rotation invariant fast features for large-scale recognition

    Science.gov (United States)

    Takacs, Gabriel; Chandrasekhar, Vijay; Tsai, Sam; Chen, David; Grzeszczuk, Radek; Girod, Bernd

    2012-10-01

    We present an end-to-end feature description pipeline which uses a novel interest point detector and Rotation- Invariant Fast Feature (RIFF) descriptors. The proposed RIFF algorithm is 15× faster than SURF1 while producing large-scale retrieval results that are comparable to SIFT.2 Such high-speed features benefit a range of applications from Mobile Augmented Reality (MAR) to web-scale image retrieval and analysis.

  2. Concurrent Programming Using Actors: Exploiting Large-Scale Parallelism,

    Science.gov (United States)

    1985-10-07

    ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK* Artificial Inteligence Laboratory AREA Is WORK UNIT NUMBERS 545 Technology Square...D-R162 422 CONCURRENT PROGRMMIZNG USING f"OS XL?ITP TEH l’ LARGE-SCALE PARALLELISH(U) NASI AC E Al CAMBRIDGE ARTIFICIAL INTELLIGENCE L. G AGHA ET AL...RESOLUTION TEST CHART N~ATIONAL BUREAU OF STANDA.RDS - -96 A -E. __ _ __ __’ .,*- - -- •. - MASSACHUSETTS INSTITUTE OF TECHNOLOGY ARTIFICIAL

  3. On a Game of Large-Scale Projects Competition

    Science.gov (United States)

    Nikonov, Oleg I.; Medvedeva, Marina A.

    2009-09-01

    The paper is devoted to game-theoretical control problems motivated by economic decision making situations arising in realization of large-scale projects, such as designing and putting into operations the new gas or oil pipelines. A non-cooperative two player game is considered with payoff functions of special type for which standard existence theorems and algorithms for searching Nash equilibrium solutions are not applicable. The paper is based on and develops the results obtained in [1]-[5].

  4. The Phoenix series large scale LNG pool fire experiments.

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Richard B.; Jensen, Richard Pearson; Demosthenous, Byron; Luketa, Anay Josephine; Ricks, Allen Joseph; Hightower, Marion Michael; Blanchat, Thomas K.; Helmick, Paul H.; Tieszen, Sheldon Robert; Deola, Regina Anne; Mercier, Jeffrey Alan; Suo-Anttila, Jill Marie; Miller, Timothy J.

    2010-12-01

    The increasing demand for natural gas could increase the number and frequency of Liquefied Natural Gas (LNG) tanker deliveries to ports across the United States. Because of the increasing number of shipments and the number of possible new facilities, concerns about the potential safety of the public and property from an accidental, and even more importantly intentional spills, have increased. While improvements have been made over the past decade in assessing hazards from LNG spills, the existing experimental data is much smaller in size and scale than many postulated large accidental and intentional spills. Since the physics and hazards from a fire change with fire size, there are concerns about the adequacy of current hazard prediction techniques for large LNG spills and fires. To address these concerns, Congress funded the Department of Energy (DOE) in 2008 to conduct a series of laboratory and large-scale LNG pool fire experiments at Sandia National Laboratories (Sandia) in Albuquerque, New Mexico. This report presents the test data and results of both sets of fire experiments. A series of five reduced-scale (gas burner) tests (yielding 27 sets of data) were conducted in 2007 and 2008 at Sandia's Thermal Test Complex (TTC) to assess flame height to fire diameter ratios as a function of nondimensional heat release rates for extrapolation to large-scale LNG fires. The large-scale LNG pool fire experiments were conducted in a 120 m diameter pond specially designed and constructed in Sandia's Area III large-scale test complex. Two fire tests of LNG spills of 21 and 81 m in diameter were conducted in 2009 to improve the understanding of flame height, smoke production, and burn rate and therefore the physics and hazards of large LNG spills and fires.

  5. Large scale 2D spectral compressed sensing in continuous domain

    KAUST Repository

    Cai, Jian-Feng

    2017-06-20

    We consider the problem of spectral compressed sensing in continuous domain, which aims to recover a 2-dimensional spectrally sparse signal from partially observed time samples. The signal is assumed to be a superposition of s complex sinusoids. We propose a semidefinite program for the 2D signal recovery problem. Our model is able to handle large scale 2D signals of size 500 × 500, whereas traditional approaches only handle signals of size around 20 × 20.

  6. Large scale 2D spectral compressed sensing in continuous domain

    KAUST Repository

    Cai, Jian-Feng; Xu, Weiyu; Yang, Yang

    2017-01-01

    We consider the problem of spectral compressed sensing in continuous domain, which aims to recover a 2-dimensional spectrally sparse signal from partially observed time samples. The signal is assumed to be a superposition of s complex sinusoids. We propose a semidefinite program for the 2D signal recovery problem. Our model is able to handle large scale 2D signals of size 500 × 500, whereas traditional approaches only handle signals of size around 20 × 20.

  7. Large-scale nuclear energy from the thorium cycle

    International Nuclear Information System (INIS)

    Lewis, W.B.; Duret, M.F.; Craig, D.S.; Veeder, J.I.; Bain, A.S.

    1973-02-01

    The thorium fuel cycle in CANDU (Canada Deuterium Uranium) reactors challenges breeders and fusion as the simplest means of meeting the world's large-scale demands for energy for centuries. Thorium oxide fuel allows high power density with excellent neutron economy. The combination of thorium fuel with organic caloporteur promises easy maintenance and high availability of the whole plant. The total fuelling cost including charges on the inventory is estimated to be attractively low. (author) [fr

  8. Large scale particle image velocimetry with helium filled soap bubbles

    Energy Technology Data Exchange (ETDEWEB)

    Bosbach, Johannes; Kuehn, Matthias; Wagner, Claus [German Aerospace Center (DLR), Institute of Aerodynamics and Flow Technology, Goettingen (Germany)

    2009-03-15

    The application of particle image velocimetry (PIV) to measurement of flows on large scales is a challenging necessity especially for the investigation of convective air flows. Combining helium filled soap bubbles as tracer particles with high power quality switched solid state lasers as light sources allows conducting PIV on scales of the order of several square meters. The technique was applied to mixed convection in a full scale double aisle aircraft cabin mock-up for validation of computational fluid dynamics simulations. (orig.)

  9. Fast, large-scale hologram calculation in wavelet domain

    Science.gov (United States)

    Shimobaba, Tomoyoshi; Matsushima, Kyoji; Takahashi, Takayuki; Nagahama, Yuki; Hasegawa, Satoki; Sano, Marie; Hirayama, Ryuji; Kakue, Takashi; Ito, Tomoyoshi

    2018-04-01

    We propose a large-scale hologram calculation using WAvelet ShrinkAge-Based superpositIon (WASABI), a wavelet transform-based algorithm. An image-type hologram calculated using the WASABI method is printed on a glass substrate with the resolution of 65 , 536 × 65 , 536 pixels and a pixel pitch of 1 μm. The hologram calculation time amounts to approximately 354 s on a commercial CPU, which is approximately 30 times faster than conventional methods.

  10. Evolutionary leap in large-scale flood risk assessment needed

    OpenAIRE

    Vorogushyn, Sergiy; Bates, Paul D.; de Bruijn, Karin; Castellarin, Attilio; Kreibich, Heidi; Priest, Sally J.; Schröter, Kai; Bagli, Stefano; Blöschl, Günter; Domeneghetti, Alessio; Gouldby, Ben; Klijn, Frans; Lammersen, Rita; Neal, Jeffrey C.; Ridder, Nina

    2018-01-01

    Current approaches for assessing large-scale flood risks contravene the fundamental principles of the flood risk system functioning because they largely ignore basic interactions and feedbacks between atmosphere, catchments, river-floodplain systems and socio-economic processes. As a consequence, risk analyses are uncertain and might be biased. However, reliable risk estimates are required for prioritizing national investments in flood risk mitigation or for appraisal and management of insura...

  11. Large scale particle image velocimetry with helium filled soap bubbles

    Science.gov (United States)

    Bosbach, Johannes; Kühn, Matthias; Wagner, Claus

    2009-03-01

    The application of Particle Image Velocimetry (PIV) to measurement of flows on large scales is a challenging necessity especially for the investigation of convective air flows. Combining helium filled soap bubbles as tracer particles with high power quality switched solid state lasers as light sources allows conducting PIV on scales of the order of several square meters. The technique was applied to mixed convection in a full scale double aisle aircraft cabin mock-up for validation of Computational Fluid Dynamics simulations.

  12. Large-scale Health Information Database and Privacy Protection*1

    OpenAIRE

    YAMAMOTO, Ryuichi

    2016-01-01

    Japan was once progressive in the digitalization of healthcare fields but unfortunately has fallen behind in terms of the secondary use of data for public interest. There has recently been a trend to establish large-scale health databases in the nation, and a conflict between data use for public interest and privacy protection has surfaced as this trend has progressed. Databases for health insurance claims or for specific health checkups and guidance services were created according to the law...

  13. Large-scale preparation of hollow graphitic carbon nanospheres

    International Nuclear Information System (INIS)

    Feng, Jun; Li, Fu; Bai, Yu-Jun; Han, Fu-Dong; Qi, Yong-Xin; Lun, Ning; Lu, Xi-Feng

    2013-01-01

    Hollow graphitic carbon nanospheres (HGCNSs) were synthesized on large scale by a simple reaction between glucose and Mg at 550 °C in an autoclave. Characterization by X-ray diffraction, Raman spectroscopy and transmission electron microscopy demonstrates the formation of HGCNSs with an average diameter of 10 nm or so and a wall thickness of a few graphenes. The HGCNSs exhibit a reversible capacity of 391 mAh g −1 after 60 cycles when used as anode materials for Li-ion batteries. -- Graphical abstract: Hollow graphitic carbon nanospheres could be prepared on large scale by the simple reaction between glucose and Mg at 550 °C, which exhibit superior electrochemical performance to graphite. Highlights: ► Hollow graphitic carbon nanospheres (HGCNSs) were prepared on large scale at 550 °C ► The preparation is simple, effective and eco-friendly. ► The in situ yielded MgO nanocrystals promote the graphitization. ► The HGCNSs exhibit superior electrochemical performance to graphite.

  14. Homogenization of Large-Scale Movement Models in Ecology

    Science.gov (United States)

    Garlick, M.J.; Powell, J.A.; Hooten, M.B.; McFarlane, L.R.

    2011-01-01

    A difficulty in using diffusion models to predict large scale animal population dispersal is that individuals move differently based on local information (as opposed to gradients) in differing habitat types. This can be accommodated by using ecological diffusion. However, real environments are often spatially complex, limiting application of a direct approach. Homogenization for partial differential equations has long been applied to Fickian diffusion (in which average individual movement is organized along gradients of habitat and population density). We derive a homogenization procedure for ecological diffusion and apply it to a simple model for chronic wasting disease in mule deer. Homogenization allows us to determine the impact of small scale (10-100 m) habitat variability on large scale (10-100 km) movement. The procedure generates asymptotic equations for solutions on the large scale with parameters defined by small-scale variation. The simplicity of this homogenization procedure is striking when compared to the multi-dimensional homogenization procedure for Fickian diffusion,and the method will be equally straightforward for more complex models. ?? 2010 Society for Mathematical Biology.

  15. Multiresolution comparison of precipitation datasets for large-scale models

    Science.gov (United States)

    Chun, K. P.; Sapriza Azuri, G.; Davison, B.; DeBeer, C. M.; Wheater, H. S.

    2014-12-01

    Gridded precipitation datasets are crucial for driving large-scale models which are related to weather forecast and climate research. However, the quality of precipitation products is usually validated individually. Comparisons between gridded precipitation products along with ground observations provide another avenue for investigating how the precipitation uncertainty would affect the performance of large-scale models. In this study, using data from a set of precipitation gauges over British Columbia and Alberta, we evaluate several widely used North America gridded products including the Canadian Gridded Precipitation Anomalies (CANGRD), the National Center for Environmental Prediction (NCEP) reanalysis, the Water and Global Change (WATCH) project, the thin plate spline smoothing algorithms (ANUSPLIN) and Canadian Precipitation Analysis (CaPA). Based on verification criteria for various temporal and spatial scales, results provide an assessment of possible applications for various precipitation datasets. For long-term climate variation studies (~100 years), CANGRD, NCEP, WATCH and ANUSPLIN have different comparative advantages in terms of their resolution and accuracy. For synoptic and mesoscale precipitation patterns, CaPA provides appealing performance of spatial coherence. In addition to the products comparison, various downscaling methods are also surveyed to explore new verification and bias-reduction methods for improving gridded precipitation outputs for large-scale models.

  16. BILGO: Bilateral greedy optimization for large scale semidefinite programming

    KAUST Repository

    Hao, Zhifeng

    2013-10-03

    Many machine learning tasks (e.g. metric and manifold learning problems) can be formulated as convex semidefinite programs. To enable the application of these tasks on a large-scale, scalability and computational efficiency are considered as desirable properties for a practical semidefinite programming algorithm. In this paper, we theoretically analyze a new bilateral greedy optimization (denoted BILGO) strategy in solving general semidefinite programs on large-scale datasets. As compared to existing methods, BILGO employs a bilateral search strategy during each optimization iteration. In such an iteration, the current semidefinite matrix solution is updated as a bilateral linear combination of the previous solution and a suitable rank-1 matrix, which can be efficiently computed from the leading eigenvector of the descent direction at this iteration. By optimizing for the coefficients of the bilateral combination, BILGO reduces the cost function in every iteration until the KKT conditions are fully satisfied, thus, it tends to converge to a global optimum. In fact, we prove that BILGO converges to the global optimal solution at a rate of O(1/k), where k is the iteration counter. The algorithm thus successfully combines the efficiency of conventional rank-1 update algorithms and the effectiveness of gradient descent. Moreover, BILGO can be easily extended to handle low rank constraints. To validate the effectiveness and efficiency of BILGO, we apply it to two important machine learning tasks, namely Mahalanobis metric learning and maximum variance unfolding. Extensive experimental results clearly demonstrate that BILGO can solve large-scale semidefinite programs efficiently.

  17. Human visual system automatically represents large-scale sequential regularities.

    Science.gov (United States)

    Kimura, Motohiro; Widmann, Andreas; Schröger, Erich

    2010-03-04

    Our brain recordings reveal that large-scale sequential regularities defined across non-adjacent stimuli can be automatically represented in visual sensory memory. To show that, we adopted an auditory paradigm developed by Sussman, E., Ritter, W., and Vaughan, H. G. Jr. (1998). Predictability of stimulus deviance and the mismatch negativity. NeuroReport, 9, 4167-4170, Sussman, E., and Gumenyuk, V. (2005). Organization of sequential sounds in auditory memory. NeuroReport, 16, 1519-1523 to the visual domain by presenting task-irrelevant infrequent luminance-deviant stimuli (D, 20%) inserted among task-irrelevant frequent stimuli being of standard luminance (S, 80%) in randomized (randomized condition, SSSDSSSSSDSSSSD...) and fixed manners (fixed condition, SSSSDSSSSDSSSSD...). Comparing the visual mismatch negativity (visual MMN), an event-related brain potential (ERP) index of memory-mismatch processes in human visual sensory system, revealed that visual MMN elicited by deviant stimuli was reduced in the fixed compared to the randomized condition. Thus, the large-scale sequential regularity being present in the fixed condition (SSSSD) must have been represented in visual sensory memory. Interestingly, this effect did not occur in conditions with stimulus-onset asynchronies (SOAs) of 480 and 800 ms but was confined to the 160-ms SOA condition supporting the hypothesis that large-scale regularity extraction was based on perceptual grouping of the five successive stimuli defining the regularity. 2010 Elsevier B.V. All rights reserved.

  18. Large-scale preparation of hollow graphitic carbon nanospheres

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Jun; Li, Fu [Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061 (China); Bai, Yu-Jun, E-mail: byj97@126.com [Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061 (China); State Key laboratory of Crystal Materials, Shandong University, Jinan 250100 (China); Han, Fu-Dong; Qi, Yong-Xin; Lun, Ning [Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061 (China); Lu, Xi-Feng [Lunan Institute of Coal Chemical Engineering, Jining 272000 (China)

    2013-01-15

    Hollow graphitic carbon nanospheres (HGCNSs) were synthesized on large scale by a simple reaction between glucose and Mg at 550 Degree-Sign C in an autoclave. Characterization by X-ray diffraction, Raman spectroscopy and transmission electron microscopy demonstrates the formation of HGCNSs with an average diameter of 10 nm or so and a wall thickness of a few graphenes. The HGCNSs exhibit a reversible capacity of 391 mAh g{sup -1} after 60 cycles when used as anode materials for Li-ion batteries. -- Graphical abstract: Hollow graphitic carbon nanospheres could be prepared on large scale by the simple reaction between glucose and Mg at 550 Degree-Sign C, which exhibit superior electrochemical performance to graphite. Highlights: Black-Right-Pointing-Pointer Hollow graphitic carbon nanospheres (HGCNSs) were prepared on large scale at 550 Degree-Sign C Black-Right-Pointing-Pointer The preparation is simple, effective and eco-friendly. Black-Right-Pointing-Pointer The in situ yielded MgO nanocrystals promote the graphitization. Black-Right-Pointing-Pointer The HGCNSs exhibit superior electrochemical performance to graphite.

  19. Study of a large scale neutron measurement channel

    International Nuclear Information System (INIS)

    Amarouayache, Anissa; Ben Hadid, Hayet.

    1982-12-01

    A large scale measurement channel allows the processing of the signal coming from an unique neutronic sensor, during three different running modes: impulses, fluctuations and current. The study described in this note includes three parts: - A theoretical study of the large scale channel and its brief description are given. The results obtained till now in that domain are presented. - The fluctuation mode is thoroughly studied and the improvements to be done are defined. The study of a fluctuation linear channel with an automatic commutation of scales is described and the results of the tests are given. In this large scale channel, the method of data processing is analogical. - To become independent of the problems generated by the use of a an analogical processing of the fluctuation signal, a digital method of data processing is tested. The validity of that method is improved. The results obtained on a test system realized according to this method are given and a preliminary plan for further research is defined [fr

  20. Critical thinking, politics on a large scale and media democracy

    Directory of Open Access Journals (Sweden)

    José Antonio IBÁÑEZ-MARTÍN

    2015-06-01

    Full Text Available The first approximation to the social current reality offers us numerous motives for the worry. The spectacle of violence and of immorality can scare us easily. But more worrying still it is to verify that the horizon of conviviality, peace and wellbeing that Europe had been developing from the Treaty of Rome of 1957 has compromised itself seriously for the economic crisis. Today we are before an assault to the democratic politics, which is qualified, on the part of the media democracy, as an exhausted system, which is required to be changed into a new and great politics, a politics on a large scale. The article analyses the concept of a politics on a large scale, primarily attending to Nietzsche, and noting its union with the great philosophy and the great education. The study of the texts of Nietzsche leads us to the conclusion of how in them we often find an interesting analysis of the problems and a misguided proposal for solutions. We cannot think to suggest solutions to all the problems, but we outline various proposals about changes of political activity, that reasonably are defended from the media democracy. In conclusion, we point out that a politics on a large scale requires statesmen, able to suggest modes of life in common that can structure a long-term coexistence.

  1. Geospatial Optimization of Siting Large-Scale Solar Projects

    Energy Technology Data Exchange (ETDEWEB)

    Macknick, Jordan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Quinby, Ted [National Renewable Energy Lab. (NREL), Golden, CO (United States); Caulfield, Emmet [Stanford Univ., CA (United States); Gerritsen, Margot [Stanford Univ., CA (United States); Diffendorfer, Jay [U.S. Geological Survey, Boulder, CO (United States); Haines, Seth [U.S. Geological Survey, Boulder, CO (United States)

    2014-03-01

    Recent policy and economic conditions have encouraged a renewed interest in developing large-scale solar projects in the U.S. Southwest. However, siting large-scale solar projects is complex. In addition to the quality of the solar resource, solar developers must take into consideration many environmental, social, and economic factors when evaluating a potential site. This report describes a proof-of-concept, Web-based Geographical Information Systems (GIS) tool that evaluates multiple user-defined criteria in an optimization algorithm to inform discussions and decisions regarding the locations of utility-scale solar projects. Existing siting recommendations for large-scale solar projects from governmental and non-governmental organizations are not consistent with each other, are often not transparent in methods, and do not take into consideration the differing priorities of stakeholders. The siting assistance GIS tool we have developed improves upon the existing siting guidelines by being user-driven, transparent, interactive, capable of incorporating multiple criteria, and flexible. This work provides the foundation for a dynamic siting assistance tool that can greatly facilitate siting decisions among multiple stakeholders.

  2. Parallel clustering algorithm for large-scale biological data sets.

    Science.gov (United States)

    Wang, Minchao; Zhang, Wu; Ding, Wang; Dai, Dongbo; Zhang, Huiran; Xie, Hao; Chen, Luonan; Guo, Yike; Xie, Jiang

    2014-01-01

    Recent explosion of biological data brings a great challenge for the traditional clustering algorithms. With increasing scale of data sets, much larger memory and longer runtime are required for the cluster identification problems. The affinity propagation algorithm outperforms many other classical clustering algorithms and is widely applied into the biological researches. However, the time and space complexity become a great bottleneck when handling the large-scale data sets. Moreover, the similarity matrix, whose constructing procedure takes long runtime, is required before running the affinity propagation algorithm, since the algorithm clusters data sets based on the similarities between data pairs. Two types of parallel architectures are proposed in this paper to accelerate the similarity matrix constructing procedure and the affinity propagation algorithm. The memory-shared architecture is used to construct the similarity matrix, and the distributed system is taken for the affinity propagation algorithm, because of its large memory size and great computing capacity. An appropriate way of data partition and reduction is designed in our method, in order to minimize the global communication cost among processes. A speedup of 100 is gained with 128 cores. The runtime is reduced from serval hours to a few seconds, which indicates that parallel algorithm is capable of handling large-scale data sets effectively. The parallel affinity propagation also achieves a good performance when clustering large-scale gene data (microarray) and detecting families in large protein superfamilies.

  3. Accelerating large-scale phase-field simulations with GPU

    Directory of Open Access Journals (Sweden)

    Xiaoming Shi

    2017-10-01

    Full Text Available A new package for accelerating large-scale phase-field simulations was developed by using GPU based on the semi-implicit Fourier method. The package can solve a variety of equilibrium equations with different inhomogeneity including long-range elastic, magnetostatic, and electrostatic interactions. Through using specific algorithm in Compute Unified Device Architecture (CUDA, Fourier spectral iterative perturbation method was integrated in GPU package. The Allen-Cahn equation, Cahn-Hilliard equation, and phase-field model with long-range interaction were solved based on the algorithm running on GPU respectively to test the performance of the package. From the comparison of the calculation results between the solver executed in single CPU and the one on GPU, it was found that the speed on GPU is enormously elevated to 50 times faster. The present study therefore contributes to the acceleration of large-scale phase-field simulations and provides guidance for experiments to design large-scale functional devices.

  4. Problems of large-scale vertically-integrated aquaculture

    Energy Technology Data Exchange (ETDEWEB)

    Webber, H H; Riordan, P F

    1976-01-01

    The problems of vertically-integrated aquaculture are outlined; they are concerned with: species limitations (in the market, biological and technological); site selection, feed, manpower needs, and legal, institutional and financial requirements. The gaps in understanding of, and the constraints limiting, large-scale aquaculture are listed. Future action is recommended with respect to: types and diversity of species to be cultivated, marketing, biotechnology (seed supply, disease control, water quality and concerted effort), siting, feed, manpower, legal and institutional aids (granting of water rights, grants, tax breaks, duty-free imports, etc.), and adequate financing. The last of hard data based on experience suggests that large-scale vertically-integrated aquaculture is a high risk enterprise, and with the high capital investment required, banks and funding institutions are wary of supporting it. Investment in pilot projects is suggested to demonstrate that large-scale aquaculture can be a fully functional and successful business. Construction and operation of such pilot farms is judged to be in the interests of both the public and private sector.

  5. Large-scale fracture mechancis testing -- requirements and possibilities

    International Nuclear Information System (INIS)

    Brumovsky, M.

    1993-01-01

    Application of fracture mechanics to very important and/or complicated structures, like reactor pressure vessels, brings also some questions about the reliability and precision of such calculations. These problems become more pronounced in cases of elastic-plastic conditions of loading and/or in parts with non-homogeneous materials (base metal and austenitic cladding, property gradient changes through material thickness) or with non-homogeneous stress fields (nozzles, bolt threads, residual stresses etc.). For such special cases some verification by large-scale testing is necessary and valuable. This paper discusses problems connected with planning of such experiments with respect to their limitations, requirements to a good transfer of received results to an actual vessel. At the same time, an analysis of possibilities of small-scale model experiments is also shown, mostly in connection with application of results between standard, small-scale and large-scale experiments. Experience from 30 years of large-scale testing in SKODA is used as an example to support this analysis. 1 fig

  6. BILGO: Bilateral greedy optimization for large scale semidefinite programming

    KAUST Repository

    Hao, Zhifeng; Yuan, Ganzhao; Ghanem, Bernard

    2013-01-01

    Many machine learning tasks (e.g. metric and manifold learning problems) can be formulated as convex semidefinite programs. To enable the application of these tasks on a large-scale, scalability and computational efficiency are considered as desirable properties for a practical semidefinite programming algorithm. In this paper, we theoretically analyze a new bilateral greedy optimization (denoted BILGO) strategy in solving general semidefinite programs on large-scale datasets. As compared to existing methods, BILGO employs a bilateral search strategy during each optimization iteration. In such an iteration, the current semidefinite matrix solution is updated as a bilateral linear combination of the previous solution and a suitable rank-1 matrix, which can be efficiently computed from the leading eigenvector of the descent direction at this iteration. By optimizing for the coefficients of the bilateral combination, BILGO reduces the cost function in every iteration until the KKT conditions are fully satisfied, thus, it tends to converge to a global optimum. In fact, we prove that BILGO converges to the global optimal solution at a rate of O(1/k), where k is the iteration counter. The algorithm thus successfully combines the efficiency of conventional rank-1 update algorithms and the effectiveness of gradient descent. Moreover, BILGO can be easily extended to handle low rank constraints. To validate the effectiveness and efficiency of BILGO, we apply it to two important machine learning tasks, namely Mahalanobis metric learning and maximum variance unfolding. Extensive experimental results clearly demonstrate that BILGO can solve large-scale semidefinite programs efficiently.

  7. Utilization of Large Scale Surface Models for Detailed Visibility Analyses

    Science.gov (United States)

    Caha, J.; Kačmařík, M.

    2017-11-01

    This article demonstrates utilization of large scale surface models with small spatial resolution and high accuracy, acquired from Unmanned Aerial Vehicle scanning, for visibility analyses. The importance of large scale data for visibility analyses on the local scale, where the detail of the surface model is the most defining factor, is described. The focus is not only the classic Boolean visibility, that is usually determined within GIS, but also on so called extended viewsheds that aims to provide more information about visibility. The case study with examples of visibility analyses was performed on river Opava, near the Ostrava city (Czech Republic). The multiple Boolean viewshed analysis and global horizon viewshed were calculated to determine most prominent features and visibility barriers of the surface. Besides that, the extended viewshed showing angle difference above the local horizon, which describes angular height of the target area above the barrier, is shown. The case study proved that large scale models are appropriate data source for visibility analyses on local level. The discussion summarizes possible future applications and further development directions of visibility analyses.

  8. Photorealistic large-scale urban city model reconstruction.

    Science.gov (United States)

    Poullis, Charalambos; You, Suya

    2009-01-01

    The rapid and efficient creation of virtual environments has become a crucial part of virtual reality applications. In particular, civil and defense applications often require and employ detailed models of operations areas for training, simulations of different scenarios, planning for natural or man-made events, monitoring, surveillance, games, and films. A realistic representation of the large-scale environments is therefore imperative for the success of such applications since it increases the immersive experience of its users and helps reduce the difference between physical and virtual reality. However, the task of creating such large-scale virtual environments still remains a time-consuming and manual work. In this work, we propose a novel method for the rapid reconstruction of photorealistic large-scale virtual environments. First, a novel, extendible, parameterized geometric primitive is presented for the automatic building identification and reconstruction of building structures. In addition, buildings with complex roofs containing complex linear and nonlinear surfaces are reconstructed interactively using a linear polygonal and a nonlinear primitive, respectively. Second, we present a rendering pipeline for the composition of photorealistic textures, which unlike existing techniques, can recover missing or occluded texture information by integrating multiple information captured from different optical sensors (ground, aerial, and satellite).

  9. Image-based Exploration of Large-Scale Pathline Fields

    KAUST Repository

    Nagoor, Omniah H.

    2014-05-27

    While real-time applications are nowadays routinely used in visualizing large nu- merical simulations and volumes, handling these large-scale datasets requires high-end graphics clusters or supercomputers to process and visualize them. However, not all users have access to powerful clusters. Therefore, it is challenging to come up with a visualization approach that provides insight to large-scale datasets on a single com- puter. Explorable images (EI) is one of the methods that allows users to handle large data on a single workstation. Although it is a view-dependent method, it combines both exploration and modification of visual aspects without re-accessing the original huge data. In this thesis, we propose a novel image-based method that applies the concept of EI in visualizing large flow-field pathlines data. The goal of our work is to provide an optimized image-based method, which scales well with the dataset size. Our approach is based on constructing a per-pixel linked list data structure in which each pixel contains a list of pathlines segments. With this view-dependent method it is possible to filter, color-code and explore large-scale flow data in real-time. In addition, optimization techniques such as early-ray termination and deferred shading are applied, which further improves the performance and scalability of our approach.

  10. [A large-scale accident in Alpine terrain].

    Science.gov (United States)

    Wildner, M; Paal, P

    2015-02-01

    Due to the geographical conditions, large-scale accidents amounting to mass casualty incidents (MCI) in Alpine terrain regularly present rescue teams with huge challenges. Using an example incident, specific conditions and typical problems associated with such a situation are presented. The first rescue team members to arrive have the elementary tasks of qualified triage and communication to the control room, which is required to dispatch the necessary additional support. Only with a clear "concept", to which all have to adhere, can the subsequent chaos phase be limited. In this respect, a time factor confounded by adverse weather conditions or darkness represents enormous pressure. Additional hazards are frostbite and hypothermia. If priorities can be established in terms of urgency, then treatment and procedure algorithms have proven successful. For evacuation of causalities, a helicopter should be strived for. Due to the low density of hospitals in Alpine regions, it is often necessary to distribute the patients over a wide area. Rescue operations in Alpine terrain have to be performed according to the particular conditions and require rescue teams to have specific knowledge and expertise. The possibility of a large-scale accident should be considered when planning events. With respect to optimization of rescue measures, regular training and exercises are rational, as is the analysis of previous large-scale Alpine accidents.

  11. Robust large-scale parallel nonlinear solvers for simulations.

    Energy Technology Data Exchange (ETDEWEB)

    Bader, Brett William; Pawlowski, Roger Patrick; Kolda, Tamara Gibson (Sandia National Laboratories, Livermore, CA)

    2005-11-01

    This report documents research to develop robust and efficient solution techniques for solving large-scale systems of nonlinear equations. The most widely used method for solving systems of nonlinear equations is Newton's method. While much research has been devoted to augmenting Newton-based solvers (usually with globalization techniques), little has been devoted to exploring the application of different models. Our research has been directed at evaluating techniques using different models than Newton's method: a lower order model, Broyden's method, and a higher order model, the tensor method. We have developed large-scale versions of each of these models and have demonstrated their use in important applications at Sandia. Broyden's method replaces the Jacobian with an approximation, allowing codes that cannot evaluate a Jacobian or have an inaccurate Jacobian to converge to a solution. Limited-memory methods, which have been successful in optimization, allow us to extend this approach to large-scale problems. We compare the robustness and efficiency of Newton's method, modified Newton's method, Jacobian-free Newton-Krylov method, and our limited-memory Broyden method. Comparisons are carried out for large-scale applications of fluid flow simulations and electronic circuit simulations. Results show that, in cases where the Jacobian was inaccurate or could not be computed, Broyden's method converged in some cases where Newton's method failed to converge. We identify conditions where Broyden's method can be more efficient than Newton's method. We also present modifications to a large-scale tensor method, originally proposed by Bouaricha, for greater efficiency, better robustness, and wider applicability. Tensor methods are an alternative to Newton-based methods and are based on computing a step based on a local quadratic model rather than a linear model. The advantage of Bouaricha's method is that it can use any

  12. Foundational perspectives on causality in large-scale brain networks

    Science.gov (United States)

    Mannino, Michael; Bressler, Steven L.

    2015-12-01

    A profusion of recent work in cognitive neuroscience has been concerned with the endeavor to uncover causal influences in large-scale brain networks. However, despite the fact that many papers give a nod to the important theoretical challenges posed by the concept of causality, this explosion of research has generally not been accompanied by a rigorous conceptual analysis of the nature of causality in the brain. This review provides both a descriptive and prescriptive account of the nature of causality as found within and between large-scale brain networks. In short, it seeks to clarify the concept of causality in large-scale brain networks both philosophically and scientifically. This is accomplished by briefly reviewing the rich philosophical history of work on causality, especially focusing on contributions by David Hume, Immanuel Kant, Bertrand Russell, and Christopher Hitchcock. We go on to discuss the impact that various interpretations of modern physics have had on our understanding of causality. Throughout all this, a central focus is the distinction between theories of deterministic causality (DC), whereby causes uniquely determine their effects, and probabilistic causality (PC), whereby causes change the probability of occurrence of their effects. We argue that, given the topological complexity of its large-scale connectivity, the brain should be considered as a complex system and its causal influences treated as probabilistic in nature. We conclude that PC is well suited for explaining causality in the brain for three reasons: (1) brain causality is often mutual; (2) connectional convergence dictates that only rarely is the activity of one neuronal population uniquely determined by another one; and (3) the causal influences exerted between neuronal populations may not have observable effects. A number of different techniques are currently available to characterize causal influence in the brain. Typically, these techniques quantify the statistical

  13. Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

    DEFF Research Database (Denmark)

    Beier-Holgersen, R; Brandstrup, B

    2012-01-01

    The aim of this study was to discover if the cellular immunological response is different in patients receiving early postoperative enteral nutrition compared to patients who only receive "water".......The aim of this study was to discover if the cellular immunological response is different in patients receiving early postoperative enteral nutrition compared to patients who only receive "water"....

  14. Large-scale control of mosquito vectors of disease

    International Nuclear Information System (INIS)

    Curtis, C.F.; Andreasen, M.H.

    2000-01-01

    By far the most important vector borne disease is malaria transmitted by Anopheles mosquitoes causing an estimated 300-500 million clinical cases per year and 1.4-2.6 million deaths, mostly in tropical Africa (WHO 1995). The second most important mosquito borne disease is lymphatic filariasis, but there are now such effective, convenient and cheap drugs for its treatment that vector control will now have at most a supplementary role (Maxwell et al. 1999a). The only other mosquito borne disease likely to justify large-scale vector control is dengue which is carried in urban areas of Southeast Asia and Latin America by Aedes aegypti L. which was also the urban vector of yellow fever in Latin America. This mosquito was eradicated from most countries of Latin America between the 1930s and 60s but, unfortunately in recent years, it has been allowed to re-infest and cause serious dengue epidemics, except in Cuba where it has been held close to eradication (Reiter and Gubler 1997). In the 1930s and 40s, invasions by An. gambiae Giles s.l., the main tropical African malaria vector, were eradicated from Brazil (Soper and Wilson 1943) and Egypt (Shousha 1947). It is surprising that greatly increased air traffic has not led to more such invasions of apparently climatically suitable areas, e.g., of Polynesia which has no anophelines and therefore no malaria. The above mentioned temporary or permanent eradications were achieved before the advent of DDT, using larvicidal methods (of a kind which would now be considered environmentally unacceptable) carried out by rigorously disciplined teams. MALARIA Between the end of the Second World War and the 1960s, the availability of DDT for spraying of houses allowed eradication of malaria from the Soviet Union, southern Europe, the USA, northern Venezuela and Guyana, Taiwan and the Caribbean Islands, apart from Hispaniola. Its range and intensity were also greatly reduced in China, India and South Africa and, at least temporarily, in

  15. Large-scale compositional heterogeneity in the Earth's mantle

    Science.gov (United States)

    Ballmer, M.

    2017-12-01

    Seismic imaging of subducted Farallon and Tethys lithosphere in the lower mantle has been taken as evidence for whole-mantle convection, and efficient mantle mixing. However, cosmochemical constraints point to a lower-mantle composition that has a lower Mg/Si compared to upper-mantle pyrolite. Moreover, geochemical signatures of magmatic rocks indicate the long-term persistence of primordial reservoirs somewhere in the mantle. In this presentation, I establish geodynamic mechanisms for sustaining large-scale (primordial) heterogeneity in the Earth's mantle using numerical models. Mantle flow is controlled by rock density and viscosity. Variations in intrinsic rock density, such as due to heterogeneity in basalt or iron content, can induce layering or partial layering in the mantle. Layering can be sustained in the presence of persistent whole mantle convection due to active "unmixing" of heterogeneity in low-viscosity domains, e.g. in the transition zone or near the core-mantle boundary [1]. On the other hand, lateral variations in intrinsic rock viscosity, such as due to heterogeneity in Mg/Si, can strongly affect the mixing timescales of the mantle. In the extreme case, intrinsically strong rocks may remain unmixed through the age of the Earth, and persist as large-scale domains in the mid-mantle due to focusing of deformation along weak conveyor belts [2]. That large-scale lateral heterogeneity and/or layering can persist in the presence of whole-mantle convection can explain the stagnation of some slabs, as well as the deflection of some plumes, in the mid-mantle. These findings indeed motivate new seismic studies for rigorous testing of model predictions. [1] Ballmer, M. D., N. C. Schmerr, T. Nakagawa, and J. Ritsema (2015), Science Advances, doi:10.1126/sciadv.1500815. [2] Ballmer, M. D., C. Houser, J. W. Hernlund, R. Wentzcovitch, and K. Hirose (2017), Nature Geoscience, doi:10.1038/ngeo2898.

  16. Large-Scale Traveling Weather Systems in Mars’ Southern Extratropics

    Science.gov (United States)

    Hollingsworth, Jeffery L.; Kahre, Melinda A.

    2017-10-01

    Between late fall and early spring, Mars’ middle- and high-latitude atmosphere supports strong mean equator-to-pole temperature contrasts and an accompanying mean westerly polar vortex. Observations from both the MGS Thermal Emission Spectrometer (TES) and the MRO Mars Climate Sounder (MCS) indicate that a mean baroclinicity-barotropicity supports intense, large-scale eastward traveling weather systems (i.e., transient synoptic-period waves). Such extratropical weather disturbances are critical components of the global circulation as they serve as agents in the transport of heat and momentum, and generalized scalar/tracer quantities (e.g., atmospheric dust, water-vapor and ice clouds). The character of such traveling extratropical synoptic disturbances in Mars' southern hemisphere during late winter through early spring is investigated using a moderately high-resolution Mars global climate model (Mars GCM). This Mars GCM imposes interactively-lifted and radiatively-active dust based on a threshold value of the surface stress. The model exhibits a reasonable "dust cycle" (i.e., globally averaged, a dustier atmosphere during southern spring and summer occurs). Compared to the northern-hemisphere counterparts, the southern synoptic-period weather disturbances and accompanying frontal waves have smaller meridional and zonal scales, and are far less intense. Influences of the zonally asymmetric (i.e., east-west varying) topography on southern large-scale weather are investigated, in addition to large-scale up-slope/down-slope flows and the diurnal cycle. A southern storm zone in late winter and early spring presents in the western hemisphere via orographic influences from the Tharsis highlands, and the Argyre and Hellas impact basins. Geographically localized transient-wave activity diagnostics are constructed that illuminate dynamical differences amongst the simulations and these are presented.

  17. On the Phenomenology of an Accelerated Large-Scale Universe

    Directory of Open Access Journals (Sweden)

    Martiros Khurshudyan

    2016-10-01

    Full Text Available In this review paper, several new results towards the explanation of the accelerated expansion of the large-scale universe is discussed. On the other hand, inflation is the early-time accelerated era and the universe is symmetric in the sense of accelerated expansion. The accelerated expansion of is one of the long standing problems in modern cosmology, and physics in general. There are several well defined approaches to solve this problem. One of them is an assumption concerning the existence of dark energy in recent universe. It is believed that dark energy is responsible for antigravity, while dark matter has gravitational nature and is responsible, in general, for structure formation. A different approach is an appropriate modification of general relativity including, for instance, f ( R and f ( T theories of gravity. On the other hand, attempts to build theories of quantum gravity and assumptions about existence of extra dimensions, possible variability of the gravitational constant and the speed of the light (among others, provide interesting modifications of general relativity applicable to problems of modern cosmology, too. In particular, here two groups of cosmological models are discussed. In the first group the problem of the accelerated expansion of large-scale universe is discussed involving a new idea, named the varying ghost dark energy. On the other hand, the second group contains cosmological models addressed to the same problem involving either new parameterizations of the equation of state parameter of dark energy (like varying polytropic gas, or nonlinear interactions between dark energy and dark matter. Moreover, for cosmological models involving varying ghost dark energy, massless particle creation in appropriate radiation dominated universe (when the background dynamics is due to general relativity is demonstrated as well. Exploring the nature of the accelerated expansion of the large-scale universe involving generalized

  18. Solving large scale structure in ten easy steps with COLA

    Energy Technology Data Exchange (ETDEWEB)

    Tassev, Svetlin [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Princeton, NJ 08544 (United States); Zaldarriaga, Matias [School of Natural Sciences, Institute for Advanced Study, Olden Lane, Princeton, NJ 08540 (United States); Eisenstein, Daniel J., E-mail: stassev@cfa.harvard.edu, E-mail: matiasz@ias.edu, E-mail: deisenstein@cfa.harvard.edu [Center for Astrophysics, Harvard University, 60 Garden Street, Cambridge, MA 02138 (United States)

    2013-06-01

    We present the COmoving Lagrangian Acceleration (COLA) method: an N-body method for solving for Large Scale Structure (LSS) in a frame that is comoving with observers following trajectories calculated in Lagrangian Perturbation Theory (LPT). Unlike standard N-body methods, the COLA method can straightforwardly trade accuracy at small-scales in order to gain computational speed without sacrificing accuracy at large scales. This is especially useful for cheaply generating large ensembles of accurate mock halo catalogs required to study galaxy clustering and weak lensing, as those catalogs are essential for performing detailed error analysis for ongoing and future surveys of LSS. As an illustration, we ran a COLA-based N-body code on a box of size 100 Mpc/h with particles of mass ≈ 5 × 10{sup 9}M{sub s}un/h. Running the code with only 10 timesteps was sufficient to obtain an accurate description of halo statistics down to halo masses of at least 10{sup 11}M{sub s}un/h. This is only at a modest speed penalty when compared to mocks obtained with LPT. A standard detailed N-body run is orders of magnitude slower than our COLA-based code. The speed-up we obtain with COLA is due to the fact that we calculate the large-scale dynamics exactly using LPT, while letting the N-body code solve for the small scales, without requiring it to capture exactly the internal dynamics of halos. Achieving a similar level of accuracy in halo statistics without the COLA method requires at least 3 times more timesteps than when COLA is employed.

  19. Large-Scale Traveling Weather Systems in Mars Southern Extratropics

    Science.gov (United States)

    Hollingsworth, Jeffery L.; Kahre, Melinda A.

    2017-01-01

    Between late fall and early spring, Mars' middle- and high-latitude atmosphere supports strong mean equator-to-pole temperature contrasts and an accompanying mean westerly polar vortex. Observations from both the MGS Thermal Emission Spectrometer (TES) and the MRO Mars Climate Sounder (MCS) indicate that a mean baroclinicity-barotropicity supports intense, large-scale eastward traveling weather systems (i.e., transient synoptic-period waves). Such extratropical weather disturbances are critical components of the global circulation as they serve as agents in the transport of heat and momentum, and generalized scalar/tracer quantities (e.g., atmospheric dust, water-vapor and ice clouds). The character of such traveling extratropical synoptic disturbances in Mars' southern hemisphere during late winter through early spring is investigated using a moderately high-resolution Mars global climate model (Mars GCM). This Mars GCM imposes interactively-lifted and radiatively-active dust based on a threshold value of the surface stress. The model exhibits a reasonable "dust cycle" (i.e., globally averaged, a dustier atmosphere during southern spring and summer occurs). Compared to the northern-hemisphere counterparts, the southern synoptic-period weather disturbances and accompanying frontal waves have smaller meridional and zonal scales, and are far less intense. Influences of the zonally asymmetric (i.e., east-west varying) topography on southern large-scale weather are investigated, in addition to large-scale up-slope/down-slope flows and the diurnal cycle. A southern storm zone in late winter and early spring presents in the western hemisphere via orographic influences from the Tharsis highlands, and the Argyre and Hellas impact basins. Geographically localized transient-wave activity diagnostics are constructed that illuminate dynamical differences amongst the simulations and these are presented.

  20. Nonlinear evolution of large-scale structure in the universe

    International Nuclear Information System (INIS)

    Frenk, C.S.; White, S.D.M.; Davis, M.

    1983-01-01

    Using N-body simulations we study the nonlinear development of primordial density perturbation in an Einstein--de Sitter universe. We compare the evolution of an initial distribution without small-scale density fluctuations to evolution from a random Poisson distribution. These initial conditions mimic the assumptions of the adiabatic and isothermal theories of galaxy formation. The large-scale structures which form in the two cases are markedly dissimilar. In particular, the correlation function xi(r) and the visual appearance of our adiabatic (or ''pancake'') models match better the observed distribution of galaxies. This distribution is characterized by large-scale filamentary structure. Because the pancake models do not evolve in a self-similar fashion, the slope of xi(r) steepens with time; as a result there is a unique epoch at which these models fit the galaxy observations. We find the ratio of cutoff length to correlation length at this time to be lambda/sub min//r 0 = 5.1; its expected value in a neutrino dominated universe is 4(Ωh) -1 (H 0 = 100h km s -1 Mpc -1 ). At early epochs these models predict a negligible amplitude for xi(r) and could explain the lack of measurable clustering in the Lyα absorption lines of high-redshift quasars. However, large-scale structure in our models collapses after z = 2. If this collapse precedes galaxy formation as in the usual pancake theory, galaxies formed uncomfortably recently. The extent of this problem may depend on the cosmological model used; the present series of experiments should be extended in the future to include models with Ω<1

  1. Enteric Duplication.

    Science.gov (United States)

    Jeziorczak, Paul M; Warner, Brad W

    2018-03-01

    Enteric duplications have been described throughout the entire gastrointestinal tract. The usual perinatal presentation is an abdominal mass. Duplications associated with the foregut have associated respiratory symptoms, whereas duplications in the midgut and hindgut can present with obstructive symptoms, perforation, nausea, emesis, hemorrhage, or be asymptomatic, and identified as an incidental finding. These are differentiated from other cystic lesions by the presence of a normal gastrointestinal mucosal epithelium. Enteric duplications are located on the mesenteric side of the native structures and are often singular with tubular or cystic characteristics. Management of enteric duplications often requires operative intervention with preservation of the native blood supply and intestine. These procedures are usually very well tolerated with low morbidity.

  2. Recent Advances in Understanding Large Scale Vapour Explosions

    International Nuclear Information System (INIS)

    Board, S.J.; Hall, R.W.

    1976-01-01

    In foundries, violent explosions occur occasionally when molten metal comes into contact with water. If similar explosions can occur with other materials, hazardous situations may arise for example in LNG marine transportation accidents, or in liquid cooled reactor incidents when molten UO 2 contacts water or sodium coolant. Over the last 10 years a large body of experimental data has been obtained on the behaviour of small quantities of hot material in contact with a vaporisable coolant. Such experiments generally give low energy yields, despite producing fine fragmentation of the molten material. These events have been interpreted in terms of a wide range of phenomena such as violent boiling, liquid entrainment, bubble collapse, superheat, surface cracking and many others. Many of these studies have been aimed at understanding the small scale behaviour of the particular materials of interest. However, understanding the nature of the energetic events which were the original cause for concern may also be necessary to give confidence that violent events cannot occur for these materials in large scale situations. More recently, there has been a trend towards larger experiments and some of these have produced explosions of moderately high efficiency. Although occurrence of such large scale explosions can depend rather critically on initial conditions in a way which is not fully understood, there are signs that the interpretation of these events may be more straightforward than that of the single drop experiments. In the last two years several theoretical models for large scale explosions have appeared which attempt a self contained explanation of at least some stages of such high yield events: these have as their common feature a description of how a propagating breakdown of an initially quasi-stable distribution of materials is induced by the pressure and flow field caused by the energy release in adjacent regions. These models have led to the idea that for a full

  3. Generation Expansion Planning Considering Integrating Large-scale Wind Generation

    DEFF Research Database (Denmark)

    Zhang, Chunyu; Ding, Yi; Østergaard, Jacob

    2013-01-01

    necessitated the inclusion of more innovative and sophisticated approaches in power system investment planning. A bi-level generation expansion planning approach considering large-scale wind generation was proposed in this paper. The first phase is investment decision, while the second phase is production...... optimization decision. A multi-objective PSO (MOPSO) algorithm was introduced to solve this optimization problem, which can accelerate the convergence and guarantee the diversity of Pareto-optimal front set as well. The feasibility and effectiveness of the proposed bi-level planning approach and the MOPSO...

  4. Safeguarding aspects of large-scale commercial reprocessing plants

    International Nuclear Information System (INIS)

    1979-03-01

    The paper points out that several solutions to the problems of safeguarding large-scale plants have been put forward: (1) Increased measurement accuracy. This does not remove the problem of timely detection. (2) Continuous in-process measurement. As yet unproven and likely to be costly. (3) More extensive use of containment and surveillance. The latter appears to be feasible but requires the incorporation of safeguards into plant design and sufficient redundancy to protect the operators interests. The advantages of altering the emphasis of safeguards philosophy from quantitative goals to the analysis of diversion strategies should be considered

  5. Large-Scale Graph Processing Using Apache Giraph

    KAUST Repository

    Sakr, Sherif

    2017-01-07

    This book takes its reader on a journey through Apache Giraph, a popular distributed graph processing platform designed to bring the power of big data processing to graph data. Designed as a step-by-step self-study guide for everyone interested in large-scale graph processing, it describes the fundamental abstractions of the system, its programming models and various techniques for using the system to process graph data at scale, including the implementation of several popular and advanced graph analytics algorithms.

  6. Highly Scalable Trip Grouping for Large Scale Collective Transportation Systems

    DEFF Research Database (Denmark)

    Gidofalvi, Gyozo; Pedersen, Torben Bach; Risch, Tore

    2008-01-01

    Transportation-related problems, like road congestion, parking, and pollution, are increasing in most cities. In order to reduce traffic, recent work has proposed methods for vehicle sharing, for example for sharing cabs by grouping "closeby" cab requests and thus minimizing transportation cost...... and utilizing cab space. However, the methods published so far do not scale to large data volumes, which is necessary to facilitate large-scale collective transportation systems, e.g., ride-sharing systems for large cities. This paper presents highly scalable trip grouping algorithms, which generalize previous...

  7. Large-scale computing techniques for complex system simulations

    CERN Document Server

    Dubitzky, Werner; Schott, Bernard

    2012-01-01

    Complex systems modeling and simulation approaches are being adopted in a growing number of sectors, including finance, economics, biology, astronomy, and many more. Technologies ranging from distributed computing to specialized hardware are explored and developed to address the computational requirements arising in complex systems simulations. The aim of this book is to present a representative overview of contemporary large-scale computing technologies in the context of complex systems simulations applications. The intention is to identify new research directions in this field and

  8. Large-Scale Analysis of Network Bistability for Human Cancers

    Science.gov (United States)

    Shiraishi, Tetsuya; Matsuyama, Shinako; Kitano, Hiroaki

    2010-01-01

    Protein–protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the circuits responsible for this over- or under-expression might persist for as long as the disease state continues. This paper shows how a large-scale analysis of network bistability for various human cancers can identify genes that can potentially serve as drug targets or diagnosis biomarkers. PMID:20628618

  9. Development of Large-Scale Spacecraft Fire Safety Experiments

    DEFF Research Database (Denmark)

    Ruff, Gary A.; Urban, David L.; Fernandez-Pello, A. Carlos

    2013-01-01

    exploration missions outside of low-earth orbit and accordingly, more complex in terms of operations, logistics, and safety. This will increase the challenge of ensuring a fire-safe environment for the crew throughout the mission. Based on our fundamental uncertainty of the behavior of fires in low...... of the spacecraft fire safety risk. The activity of this project is supported by an international topical team of fire experts from other space agencies who conduct research that is integrated into the overall experiment design. The large-scale space flight experiment will be conducted in an Orbital Sciences...

  10. Large scale obscuration and related climate effects open literature bibliography

    International Nuclear Information System (INIS)

    Russell, N.A.; Geitgey, J.; Behl, Y.K.; Zak, B.D.

    1994-05-01

    Large scale obscuration and related climate effects of nuclear detonations first became a matter of concern in connection with the so-called ''Nuclear Winter Controversy'' in the early 1980's. Since then, the world has changed. Nevertheless, concern remains about the atmospheric effects of nuclear detonations, but the source of concern has shifted. Now it focuses less on global, and more on regional effects and their resulting impacts on the performance of electro-optical and other defense-related systems. This bibliography reflects the modified interest

  11. Large Scale Composite Manufacturing for Heavy Lift Launch Vehicles

    Science.gov (United States)

    Stavana, Jacob; Cohen, Leslie J.; Houseal, Keth; Pelham, Larry; Lort, Richard; Zimmerman, Thomas; Sutter, James; Western, Mike; Harper, Robert; Stuart, Michael

    2012-01-01

    Risk reduction for the large scale composite manufacturing is an important goal to produce light weight components for heavy lift launch vehicles. NASA and an industry team successfully employed a building block approach using low-cost Automated Tape Layup (ATL) of autoclave and Out-of-Autoclave (OoA) prepregs. Several large, curved sandwich panels were fabricated at HITCO Carbon Composites. The aluminum honeycomb core sandwich panels are segments of a 1/16th arc from a 10 meter cylindrical barrel. Lessons learned highlight the manufacturing challenges required to produce light weight composite structures such as fairings for heavy lift launch vehicles.

  12. Large Scale Simulations of the Euler Equations on GPU Clusters

    KAUST Repository

    Liebmann, Manfred

    2010-08-01

    The paper investigates the scalability of a parallel Euler solver, using the Vijayasundaram method, on a GPU cluster with 32 Nvidia Geforce GTX 295 boards. The aim of this research is to enable large scale fluid dynamics simulations with up to one billion elements. We investigate communication protocols for the GPU cluster to compensate for the slow Gigabit Ethernet network between the GPU compute nodes and to maintain overall efficiency. A diesel engine intake-port and a nozzle, meshed in different resolutions, give good real world examples for the scalability tests on the GPU cluster. © 2010 IEEE.

  13. Enabling Large-Scale Biomedical Analysis in the Cloud

    Directory of Open Access Journals (Sweden)

    Ying-Chih Lin

    2013-01-01

    Full Text Available Recent progress in high-throughput instrumentations has led to an astonishing growth in both volume and complexity of biomedical data collected from various sources. The planet-size data brings serious challenges to the storage and computing technologies. Cloud computing is an alternative to crack the nut because it gives concurrent consideration to enable storage and high-performance computing on large-scale data. This work briefly introduces the data intensive computing system and summarizes existing cloud-based resources in bioinformatics. These developments and applications would facilitate biomedical research to make the vast amount of diversification data meaningful and usable.

  14. Large-scale structure in the universe: Theory vs observations

    International Nuclear Information System (INIS)

    Kashlinsky, A.; Jones, B.J.T.

    1990-01-01

    A variety of observations constrain models of the origin of large scale cosmic structures. We review here the elements of current theories and comment in detail on which of the current observational data provide the principal constraints. We point out that enough observational data have accumulated to constrain (and perhaps determine) the power spectrum of primordial density fluctuations over a very large range of scales. We discuss the theories in the light of observational data and focus on the potential of future observations in providing even (and ever) tighter constraints. (orig.)

  15. Current status of large-scale cryogenic gravitational wave telescope

    International Nuclear Information System (INIS)

    Kuroda, K; Ohashi, M; Miyoki, S; Uchiyama, T; Ishitsuka, H; Yamamoto, K; Kasahara, K; Fujimoto, M-K; Kawamura, S; Takahashi, R; Yamazaki, T; Arai, K; Tatsumi, D; Ueda, A; Fukushima, M; Sato, S; Nagano, S; Tsunesada, Y; Zhu, Zong-Hong; Shintomi, T; Yamamoto, A; Suzuki, T; Saito, Y; Haruyama, T; Sato, N; Higashi, Y; Tomaru, T; Tsubono, K; Ando, M; Takamori, A; Numata, K; Aso, Y; Ueda, K-I; Yoneda, H; Nakagawa, K; Musha, M; Mio, N; Moriwaki, S; Somiya, K; Araya, A; Kanda, N; Telada, S; Tagoshi, H; Nakamura, T; Sasaki, M; Tanaka, T; Oohara, K; Takahashi, H; Miyakawa, O; Tobar, M E

    2003-01-01

    The large-scale cryogenic gravitational wave telescope (LCGT) project is the proposed advancement of TAMA, which will be able to detect the coalescences of binary neutron stars occurring in our galaxy. LCGT intends to detect the coalescence events within about 240 Mpc, the rate of which is expected to be from 0.1 to several events in a year. LCGT has Fabry-Perot cavities of 3 km baseline and the mirrors are cooled down to a cryogenic temperature of 20 K. It is planned to be built in the underground of Kamioka mine. This paper overviews the revision of the design and the current status of the R and D

  16. Large scale obscuration and related climate effects open literature bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Russell, N.A.; Geitgey, J.; Behl, Y.K.; Zak, B.D.

    1994-05-01

    Large scale obscuration and related climate effects of nuclear detonations first became a matter of concern in connection with the so-called ``Nuclear Winter Controversy`` in the early 1980`s. Since then, the world has changed. Nevertheless, concern remains about the atmospheric effects of nuclear detonations, but the source of concern has shifted. Now it focuses less on global, and more on regional effects and their resulting impacts on the performance of electro-optical and other defense-related systems. This bibliography reflects the modified interest.

  17. Properties of large-scale methane/hydrogen jet fires

    Energy Technology Data Exchange (ETDEWEB)

    Studer, E. [CEA Saclay, DEN, LTMF Heat Transfer and Fluid Mech Lab, 91 - Gif-sur-Yvette (France); Jamois, D.; Leroy, G.; Hebrard, J. [INERIS, F-60150 Verneuil En Halatte (France); Jallais, S. [Air Liquide, F-78350 Jouy En Josas (France); Blanchetiere, V. [GDF SUEZ, 93 - La Plaine St Denis (France)

    2009-12-15

    A future economy based on reduction of carbon-based fuels for power generation and transportation may consider hydrogen as possible energy carrier Extensive and widespread use of hydrogen might require a pipeline network. The alternatives might be the use of the existing natural gas network or to design a dedicated network. Whatever the solution, mixing hydrogen with natural gas will modify the consequences of accidents, substantially The French National Research Agency (ANR) funded project called HYDROMEL focuses on these critical questions Within this project large-scale jet fires have been studied experimentally and numerically The main characteristics of these flames including visible length, radiation fluxes and blowout have been assessed. (authors)

  18. Less is more: regularization perspectives on large scale machine learning

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Deep learning based techniques provide a possible solution at the expanse of theoretical guidance and, especially, of computational requirements. It is then a key challenge for large scale machine learning to devise approaches guaranteed to be accurate and yet computationally efficient. In this talk, we will consider a regularization perspectives on machine learning appealing to classical ideas in linear algebra and inverse problems to scale-up dramatically nonparametric methods such as kernel methods, often dismissed because of prohibitive costs. Our analysis derives optimal theoretical guarantees while providing experimental results at par or out-performing state of the art approaches.

  19. Large-Scale Graph Processing Using Apache Giraph

    KAUST Repository

    Sakr, Sherif; Orakzai, Faisal Moeen; Abdelaziz, Ibrahim; Khayyat, Zuhair

    2017-01-01

    This book takes its reader on a journey through Apache Giraph, a popular distributed graph processing platform designed to bring the power of big data processing to graph data. Designed as a step-by-step self-study guide for everyone interested in large-scale graph processing, it describes the fundamental abstractions of the system, its programming models and various techniques for using the system to process graph data at scale, including the implementation of several popular and advanced graph analytics algorithms.

  20. Multidimensional quantum entanglement with large-scale integrated optics

    DEFF Research Database (Denmark)

    Wang, Jianwei; Paesani, Stefano; Ding, Yunhong

    2018-01-01

    -dimensional entanglement. A programmable bipartite entangled system is realized with dimension up to 15 × 15 on a large-scale silicon-photonics quantum circuit. The device integrates more than 550 photonic components on a single chip, including 16 identical photon-pair sources. We verify the high precision, generality......The ability to control multidimensional quantum systems is key for the investigation of fundamental science and for the development of advanced quantum technologies. We demonstrate a multidimensional integrated quantum photonic platform able to generate, control and analyze high...

  1. Status of large scale wind turbine technology development abroad?

    Institute of Scientific and Technical Information of China (English)

    Ye LI; Lei DUAN

    2016-01-01

    To facilitate the large scale (multi-megawatt) wind turbine development in China, the foreign e?orts and achievements in the area are reviewed and summarized. Not only the popular horizontal axis wind turbines on-land but also the o?shore wind turbines, vertical axis wind turbines, airborne wind turbines, and shroud wind turbines are discussed. The purpose of this review is to provide a comprehensive comment and assessment about the basic work principle, economic aspects, and environmental impacts of turbines.

  2. Cosmological parameters from large scale structure - geometric versus shape information

    CERN Document Server

    Hamann, Jan; Lesgourgues, Julien; Rampf, Cornelius; Wong, Yvonne Y Y

    2010-01-01

    The matter power spectrum as derived from large scale structure (LSS) surveys contains two important and distinct pieces of information: an overall smooth shape and the imprint of baryon acoustic oscillations (BAO). We investigate the separate impact of these two types of information on cosmological parameter estimation, and show that for the simplest cosmological models, the broad-band shape information currently contained in the SDSS DR7 halo power spectrum (HPS) is by far superseded by geometric information derived from the baryonic features. An immediate corollary is that contrary to popular beliefs, the upper limit on the neutrino mass m_\

  3. Test on large-scale seismic isolation elements, 2

    International Nuclear Information System (INIS)

    Mazda, T.; Moteki, M.; Ishida, K.; Shiojiri, H.; Fujita, T.

    1991-01-01

    Seismic isolation test program of Central Research Inst. of Electric Power Industry (CRIEPI) to apply seismic isolation to Fast Breeder Reactor (FBR) plant was started in 1987. In this test program, demonstration test of seismic isolation elements was considered as one of the most important research items. Facilities for testing seismic isolation elements were built in Abiko Research Laboratory of CRIEPI. Various tests of large-scale seismic isolation elements were conducted up to this day. Many important test data to develop design technical guidelines was obtained. (author)

  4. Large scale PV plants - also in Denmark. Project report

    Energy Technology Data Exchange (ETDEWEB)

    Ahm, P [PA Energy, Malling (Denmark); Vedde, J [SiCon. Silicon and PV consulting, Birkeroed (Denmark)

    2011-04-15

    Large scale PV (LPV) plants, plants with a capacity of more than 200 kW, has since 2007 constituted an increasing share of the global PV installations. In 2009 large scale PV plants with cumulative power more that 1,3 GWp were connected to the grid. The necessary design data for LPV plants in Denmark are available or can be found, although irradiance data could be improved. There seems to be very few institutional barriers for LPV projects, but as so far no real LPV projects have been processed, these findings have to be regarded as preliminary. The fast growing number of very large scale solar thermal plants for district heating applications supports these findings. It has further been investigated, how to optimize the lay-out of LPV plants. Under the Danish irradiance conditions with several winter months with very low solar height PV installations on flat surfaces will have to balance the requirements of physical space - and cost, and the loss of electricity production due to shadowing effects. The potential for LPV plants in Denmark are found in three main categories: PV installations on flat roof of large commercial buildings, PV installations on other large scale infrastructure such as noise barriers and ground mounted PV installations. The technical potential for all three categories is found to be significant and in the range of 50 - 250 km2. In terms of energy harvest PV plants will under Danish conditions exhibit an overall efficiency of about 10 % in conversion of the energy content of the light compared to about 0,3 % for biomass. The theoretical ground area needed to produce the present annual electricity consumption of Denmark at 33-35 TWh is about 300 km2 The Danish grid codes and the electricity safety regulations mention very little about PV and nothing about LPV plants. It is expected that LPV plants will be treated similarly to big wind turbines. A number of LPV plant scenarios have been investigated in detail based on real commercial offers and

  5. Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

    International Nuclear Information System (INIS)

    Alvarez, Marcello; Baldauf, T.; Bond, J. Richard; Dalal, N.; Putter, R. D.; Dore, O.; Green, Daniel; Hirata, Chris; Huang, Zhiqi; Huterer, Dragan; Jeong, Donghui; Johnson, Matthew C.; Krause, Elisabeth; Loverde, Marilena; Meyers, Joel; Meeburg, Daniel; Senatore, Leonardo; Shandera, Sarah; Silverstein, Eva; Slosar, Anze; Smith, Kendrick; Zaldarriaga, Matias; Assassi, Valentin; Braden, Jonathan; Hajian, Amir; Kobayashi, Takeshi; Stein, George; Engelen, Alexander van

    2014-01-01

    The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations. Large-scale structure is, however, from where drastic improvements should originate. In this paper, we explain the theoretical motivations for pursuing such measurements and the challenges that lie ahead. In particular, we discuss and identify theoretical targets regarding the measurement of primordial non-Gaussianity. We argue that when quantified in terms of the local (equilateral) template amplitude floc\

  6. Design techniques for large scale linear measurement systems

    International Nuclear Information System (INIS)

    Candy, J.V.

    1979-03-01

    Techniques to design measurement schemes for systems modeled by large scale linear time invariant systems, i.e., physical systems modeled by a large number (> 5) of ordinary differential equations, are described. The techniques are based on transforming the physical system model to a coordinate system facilitating the design and then transforming back to the original coordinates. An example of a three-stage, four-species, extraction column used in the reprocessing of spent nuclear fuel elements is presented. The basic ideas are briefly discussed in the case of noisy measurements. An example using a plutonium nitrate storage vessel (reprocessing) with measurement uncertainty is also presented

  7. How Large-Scale Research Facilities Connect to Global Research

    DEFF Research Database (Denmark)

    Lauto, Giancarlo; Valentin, Finn

    2013-01-01

    Policies for large-scale research facilities (LSRFs) often highlight their spillovers to industrial innovation and their contribution to the external connectivity of the regional innovation system hosting them. Arguably, the particular institutional features of LSRFs are conducive for collaborative...... research. However, based on data on publications produced in 2006–2009 at the Neutron Science Directorate of Oak Ridge National Laboratory in Tennessee (United States), we find that internationalization of its collaborative research is restrained by coordination costs similar to those characterizing other...

  8. Novel algorithm of large-scale simultaneous linear equations

    International Nuclear Information System (INIS)

    Fujiwara, T; Hoshi, T; Yamamoto, S; Sogabe, T; Zhang, S-L

    2010-01-01

    We review our recently developed methods of solving large-scale simultaneous linear equations and applications to electronic structure calculations both in one-electron theory and many-electron theory. This is the shifted COCG (conjugate orthogonal conjugate gradient) method based on the Krylov subspace, and the most important issue for applications is the shift equation and the seed switching method, which greatly reduce the computational cost. The applications to nano-scale Si crystals and the double orbital extended Hubbard model are presented.

  9. Optimization of large scale food production using Lean Manufacturing principles

    DEFF Research Database (Denmark)

    Engelund, Eva Høy; Friis, Alan; Breum, Gitte

    2009-01-01

    This paper discusses how the production principles of Lean Manufacturing (Lean) can be applied in a large-scale meal production. Lean principles are briefly presented, followed by a field study of how a kitchen at a Danish hospital has implemented Lean in the daily production. In the kitchen...... not be negatively affected by the rationalisation of production procedures. The field study shows that Lean principles can be applied in meal production and can result in increased production efficiency and systematic improvement of product quality without negative effects on the working environment. The results...... show that Lean can be applied and used to manage the production of meals in the kitchen....

  10. 5 years of experience with a large-scale mentoring program for medical students

    Directory of Open Access Journals (Sweden)

    Pinilla, Severin

    2015-02-01

    Full Text Available In this paper we present our 5-year-experience with a large-scale mentoring program for undergraduate medical students at the Ludwig Maximilians-Universität Munich (LMU. We implemented a two-tiered program with a peer-mentoring concept for preclinical students and a 1:1-mentoring concept for clinical students aided by a fully automated online-based matching algorithm. Approximately 20-30% of each student cohort participates in our voluntary mentoring program. Defining ideal program evaluation strategies, recruiting mentors from beyond the academic environment and accounting for the mentoring network reality remain challenging. We conclude that a two-tiered program is well accepted by students and faculty. In addition the online-based matching seems to be effective for large-scale mentoring programs.

  11. Beneficial Effects of Early Enteral Nutrition After Major Rectal Surgery: A Possible Role for Conditionally Essential Amino Acids? Results of a Randomized Clinical Trial.

    Science.gov (United States)

    van Barneveld, Kevin W Y; Smeets, Boudewijn J J; Heesakkers, Fanny F B M; Bosmans, Joanna W A M; Luyer, Misha D; Wasowicz, Dareczka; Bakker, Jaap A; Roos, Arnout N; Rutten, Harm J T; Bouvy, Nicole D; Boelens, Petra G

    2016-06-01

    better clinical outcome was observed. We conclude that plasma amino acids do not provide a causal explanation for the observed beneficial effects of early enteral feeding after major rectal surgery.

  12. Topographically Engineered Large Scale Nanostructures for Plasmonic Biosensing

    Science.gov (United States)

    Xiao, Bo; Pradhan, Sangram K.; Santiago, Kevin C.; Rutherford, Gugu N.; Pradhan, Aswini K.

    2016-04-01

    We demonstrate that a nanostructured metal thin film can achieve enhanced transmission efficiency and sharp resonances and use a large-scale and high-throughput nanofabrication technique for the plasmonic structures. The fabrication technique combines the features of nanoimprint and soft lithography to topographically construct metal thin films with nanoscale patterns. Metal nanogratings developed using this method show significantly enhanced optical transmission (up to a one-order-of-magnitude enhancement) and sharp resonances with full width at half maximum (FWHM) of ~15nm in the zero-order transmission using an incoherent white light source. These nanostructures are sensitive to the surrounding environment, and the resonance can shift as the refractive index changes. We derive an analytical method using a spatial Fourier transformation to understand the enhancement phenomenon and the sensing mechanism. The use of real-time monitoring of protein-protein interactions in microfluidic cells integrated with these nanostructures is demonstrated to be effective for biosensing. The perpendicular transmission configuration and large-scale structures provide a feasible platform without sophisticated optical instrumentation to realize label-free surface plasmon resonance (SPR) sensing.

  13. Large-scale hydrogen production using nuclear reactors

    Energy Technology Data Exchange (ETDEWEB)

    Ryland, D.; Stolberg, L.; Kettner, A.; Gnanapragasam, N.; Suppiah, S. [Atomic Energy of Canada Limited, Chalk River, ON (Canada)

    2014-07-01

    For many years, Atomic Energy of Canada Limited (AECL) has been studying the feasibility of using nuclear reactors, such as the Supercritical Water-cooled Reactor, as an energy source for large scale hydrogen production processes such as High Temperature Steam Electrolysis and the Copper-Chlorine thermochemical cycle. Recent progress includes the augmentation of AECL's experimental capabilities by the construction of experimental systems to test high temperature steam electrolysis button cells at ambient pressure and temperatures up to 850{sup o}C and CuCl/HCl electrolysis cells at pressures up to 7 bar and temperatures up to 100{sup o}C. In parallel, detailed models of solid oxide electrolysis cells and the CuCl/HCl electrolysis cell are being refined and validated using experimental data. Process models are also under development to assess options for economic integration of these hydrogen production processes with nuclear reactors. Options for large-scale energy storage, including hydrogen storage, are also under study. (author)

  14. The effective field theory of cosmological large scale structures

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco, John Joseph M. [Stanford Univ., Stanford, CA (United States); Hertzberg, Mark P. [Stanford Univ., Stanford, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States); Senatore, Leonardo [Stanford Univ., Stanford, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2012-09-20

    Large scale structure surveys will likely become the next leading cosmological probe. In our universe, matter perturbations are large on short distances and small at long scales, i.e. strongly coupled in the UV and weakly coupled in the IR. To make precise analytical predictions on large scales, we develop an effective field theory formulated in terms of an IR effective fluid characterized by several parameters, such as speed of sound and viscosity. These parameters, determined by the UV physics described by the Boltzmann equation, are measured from N-body simulations. We find that the speed of sound of the effective fluid is c2s ≈ 10–6c2 and that the viscosity contributions are of the same order. The fluid describes all the relevant physics at long scales k and permits a manifestly convergent perturbative expansion in the size of the matter perturbations δ(k) for all the observables. As an example, we calculate the correction to the power spectrum at order δ(k)4. As a result, the predictions of the effective field theory are found to be in much better agreement with observation than standard cosmological perturbation theory, already reaching percent precision at this order up to a relatively short scale k ≃ 0.24h Mpc–1.

  15. Systematic renormalization of the effective theory of Large Scale Structure

    International Nuclear Information System (INIS)

    Abolhasani, Ali Akbar; Mirbabayi, Mehrdad; Pajer, Enrico

    2016-01-01

    A perturbative description of Large Scale Structure is a cornerstone of our understanding of the observed distribution of matter in the universe. Renormalization is an essential and defining step to make this description physical and predictive. Here we introduce a systematic renormalization procedure, which neatly associates counterterms to the UV-sensitive diagrams order by order, as it is commonly done in quantum field theory. As a concrete example, we renormalize the one-loop power spectrum and bispectrum of both density and velocity. In addition, we present a series of results that are valid to all orders in perturbation theory. First, we show that while systematic renormalization requires temporally non-local counterterms, in practice one can use an equivalent basis made of local operators. We give an explicit prescription to generate all counterterms allowed by the symmetries. Second, we present a formal proof of the well-known general argument that the contribution of short distance perturbations to large scale density contrast δ and momentum density π(k) scale as k 2 and k, respectively. Third, we demonstrate that the common practice of introducing counterterms only in the Euler equation when one is interested in correlators of δ is indeed valid to all orders.

  16. Evaluating Unmanned Aerial Platforms for Cultural Heritage Large Scale Mapping

    Science.gov (United States)

    Georgopoulos, A.; Oikonomou, C.; Adamopoulos, E.; Stathopoulou, E. K.

    2016-06-01

    When it comes to large scale mapping of limited areas especially for cultural heritage sites, things become critical. Optical and non-optical sensors are developed to such sizes and weights that can be lifted by such platforms, like e.g. LiDAR units. At the same time there is an increase in emphasis on solutions that enable users to get access to 3D information faster and cheaper. Considering the multitude of platforms, cameras and the advancement of algorithms in conjunction with the increase of available computing power this challenge should and indeed is further investigated. In this paper a short review of the UAS technologies today is attempted. A discussion follows as to their applicability and advantages, depending on their specifications, which vary immensely. The on-board cameras available are also compared and evaluated for large scale mapping. Furthermore a thorough analysis, review and experimentation with different software implementations of Structure from Motion and Multiple View Stereo algorithms, able to process such dense and mostly unordered sequence of digital images is also conducted and presented. As test data set, we use a rich optical and thermal data set from both fixed wing and multi-rotor platforms over an archaeological excavation with adverse height variations and using different cameras. Dense 3D point clouds, digital terrain models and orthophotos have been produced and evaluated for their radiometric as well as metric qualities.

  17. IP over optical multicasting for large-scale video delivery

    Science.gov (United States)

    Jin, Yaohui; Hu, Weisheng; Sun, Weiqiang; Guo, Wei

    2007-11-01

    In the IPTV systems, multicasting will play a crucial role in the delivery of high-quality video services, which can significantly improve bandwidth efficiency. However, the scalability and the signal quality of current IPTV can barely compete with the existing broadcast digital TV systems since it is difficult to implement large-scale multicasting with end-to-end guaranteed quality of service (QoS) in packet-switched IP network. China 3TNet project aimed to build a high performance broadband trial network to support large-scale concurrent streaming media and interactive multimedia services. The innovative idea of 3TNet is that an automatic switched optical networks (ASON) with the capability of dynamic point-to-multipoint (P2MP) connections replaces the conventional IP multicasting network in the transport core, while the edge remains an IP multicasting network. In this paper, we will introduce the network architecture and discuss challenges in such IP over Optical multicasting for video delivery.

  18. Power suppression at large scales in string inflation

    Energy Technology Data Exchange (ETDEWEB)

    Cicoli, Michele [Dipartimento di Fisica ed Astronomia, Università di Bologna, via Irnerio 46, Bologna, 40126 (Italy); Downes, Sean; Dutta, Bhaskar, E-mail: mcicoli@ictp.it, E-mail: sddownes@physics.tamu.edu, E-mail: dutta@physics.tamu.edu [Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX, 77843-4242 (United States)

    2013-12-01

    We study a possible origin of the anomalous suppression of the power spectrum at large angular scales in the cosmic microwave background within the framework of explicit string inflationary models where inflation is driven by a closed string modulus parameterizing the size of the extra dimensions. In this class of models the apparent power loss at large scales is caused by the background dynamics which involves a sharp transition from a fast-roll power law phase to a period of Starobinsky-like slow-roll inflation. An interesting feature of this class of string inflationary models is that the number of e-foldings of inflation is inversely proportional to the string coupling to a positive power. Therefore once the string coupling is tuned to small values in order to trust string perturbation theory, enough e-foldings of inflation are automatically obtained without the need of extra tuning. Moreover, in the less tuned cases the sharp transition responsible for the power loss takes place just before the last 50-60 e-foldings of inflation. We illustrate these general claims in the case of Fibre Inflation where we study the strength of this transition in terms of the attractor dynamics, finding that it induces a pivot from a blue to a redshifted power spectrum which can explain the apparent large scale power loss. We compute the effects of this pivot for example cases and demonstrate how magnitude and duration of this effect depend on model parameters.

  19. Mapping spatial patterns of denitrifiers at large scales (Invited)

    Science.gov (United States)

    Philippot, L.; Ramette, A.; Saby, N.; Bru, D.; Dequiedt, S.; Ranjard, L.; Jolivet, C.; Arrouays, D.

    2010-12-01

    Little information is available regarding the landscape-scale distribution of microbial communities and its environmental determinants. Here we combined molecular approaches and geostatistical modeling to explore spatial patterns of the denitrifying community at large scales. The distribution of denitrifrying community was investigated over 107 sites in Burgundy, a 31 500 km2 region of France, using a 16 X 16 km sampling grid. At each sampling site, the abundances of denitrifiers and 42 soil physico-chemical properties were measured. The relative contributions of land use, spatial distance, climatic conditions, time and soil physico-chemical properties to the denitrifier spatial distribution were analyzed by canonical variation partitioning. Our results indicate that 43% to 85% of the spatial variation in community abundances could be explained by the measured environmental parameters, with soil chemical properties (mostly pH) being the main driver. We found spatial autocorrelation up to 739 km and used geostatistical modelling to generate predictive maps of the distribution of denitrifiers at the landscape scale. Studying the distribution of the denitrifiers at large scale can help closing the artificial gap between the investigation of microbial processes and microbial community ecology, therefore facilitating our understanding of the relationships between the ecology of denitrifiers and N-fluxes by denitrification.

  20. State-of-the-art of large scale biogas plants

    International Nuclear Information System (INIS)

    Prisum, J.M.; Noergaard, P.

    1992-01-01

    A survey of the technological state of large scale biogas plants in Europe treating manure is given. 83 plants are in operation at present. Of these, 16 are centralised digestion plants. Transport costs at centralised digestion plants amounts to between 25 and 40 percent of the total operational costs. Various transport equipment is used. Most large scale digesters are CSTRs, but serial, contact, 2-step, and plug-flow digesters are also found. Construction materials are mostly steel and concrete. Mesophilic digestion is most common (56%), thermophilic digestion is used in 17% of the plants, combined mesophilic and thermophilic digestion is used in 28% of the centralised plants. Mixing of digester content is performed with gas injection, propellers, and gas-liquid displacement. Heating is carried out using external or internal heat exchangers. Heat recovery is only used in Denmark. Gas purification equipment is commonplace, but not often needed. Several plants use separation of the digested manure, often as part of a post-treatment/-purification process or for the production of 'compost'. Screens, sieve belt separaters, centrifuges and filter presses are employed. The use of biogas varies considerably. In some cases, combined heat and power stations are supplying the grid and district heating systems. Other plants use only either the electricity or heat. (au)

  1. Exploiting Data Sparsity for Large-Scale Matrix Computations

    KAUST Repository

    Akbudak, Kadir; Ltaief, Hatem; Mikhalev, Aleksandr; Charara, Ali; Keyes, David E.

    2018-01-01

    Exploiting data sparsity in dense matrices is an algorithmic bridge between architectures that are increasingly memory-austere on a per-core basis and extreme-scale applications. The Hierarchical matrix Computations on Manycore Architectures (HiCMA) library tackles this challenging problem by achieving significant reductions in time to solution and memory footprint, while preserving a specified accuracy requirement of the application. HiCMA provides a high-performance implementation on distributed-memory systems of one of the most widely used matrix factorization in large-scale scientific applications, i.e., the Cholesky factorization. It employs the tile low-rank data format to compress the dense data-sparse off-diagonal tiles of the matrix. It then decomposes the matrix computations into interdependent tasks and relies on the dynamic runtime system StarPU for asynchronous out-of-order scheduling, while allowing high user-productivity. Performance comparisons and memory footprint on matrix dimensions up to eleven million show a performance gain and memory saving of more than an order of magnitude for both metrics on thousands of cores, against state-of-the-art open-source and vendor optimized numerical libraries. This represents an important milestone in enabling large-scale matrix computations toward solving big data problems in geospatial statistics for climate/weather forecasting applications.

  2. Fuel pin integrity assessment under large scale transients

    International Nuclear Information System (INIS)

    Dutta, B.K.

    2006-01-01

    The integrity of fuel rods under normal, abnormal and accident conditions is an important consideration during fuel design of advanced nuclear reactors. The fuel matrix and the sheath form the first barrier to prevent the release of radioactive materials into the primary coolant. An understanding of the fuel and clad behaviour under different reactor conditions, particularly under the beyond-design-basis accident scenario leading to large scale transients, is always desirable to assess the inherent safety margins in fuel pin design and to plan for the mitigation the consequences of accidents, if any. The severe accident conditions are typically characterized by the energy deposition rates far exceeding the heat removal capability of the reactor coolant system. This may lead to the clad failure due to fission gas pressure at high temperature, large- scale pellet-clad interaction and clad melting. The fuel rod performance is affected by many interdependent complex phenomena involving extremely complex material behaviour. The versatile experimental database available in this area has led to the development of powerful analytical tools to characterize fuel under extreme scenarios

  3. Large Scale Community Detection Using a Small World Model

    Directory of Open Access Journals (Sweden)

    Ranjan Kumar Behera

    2017-11-01

    Full Text Available In a social network, small or large communities within the network play a major role in deciding the functionalities of the network. Despite of diverse definitions, communities in the network may be defined as the group of nodes that are more densely connected as compared to nodes outside the group. Revealing such hidden communities is one of the challenging research problems. A real world social network follows small world phenomena, which indicates that any two social entities can be reachable in a small number of steps. In this paper, nodes are mapped into communities based on the random walk in the network. However, uncovering communities in large-scale networks is a challenging task due to its unprecedented growth in the size of social networks. A good number of community detection algorithms based on random walk exist in literature. In addition, when large-scale social networks are being considered, these algorithms are observed to take considerably longer time. In this work, with an objective to improve the efficiency of algorithms, parallel programming framework like Map-Reduce has been considered for uncovering the hidden communities in social network. The proposed approach has been compared with some standard existing community detection algorithms for both synthetic and real-world datasets in order to examine its performance, and it is observed that the proposed algorithm is more efficient than the existing ones.

  4. Dose monitoring in large-scale flowing aqueous media

    International Nuclear Information System (INIS)

    Kuruca, C.N.

    1995-01-01

    The Miami Electron Beam Research Facility (EBRF) has been in operation for six years. The EBRF houses a 1.5 MV, 75 KW DC scanned electron beam. Experiments have been conducted to evaluate the effectiveness of high-energy electron irradiation in the removal of toxic organic chemicals from contaminated water and the disinfection of various wastewater streams. The large-scale plant operates at approximately 450 L/min (120 gal/min). The radiation dose absorbed by the flowing aqueous streams is estimated by measuring the difference in water temperature before and after it passes in front of the beam. Temperature measurements are made using resistance temperature devices (RTDs) and recorded by computer along with other operating parameters. Estimated dose is obtained from the measured temperature differences using the specific heat of water. This presentation will discuss experience with this measurement system, its application to different water presentation devices, sources of error, and the advantages and disadvantages of its use in large-scale process applications

  5. Large scale CMB anomalies from thawing cosmic strings

    Energy Technology Data Exchange (ETDEWEB)

    Ringeval, Christophe [Centre for Cosmology, Particle Physics and Phenomenology, Institute of Mathematics and Physics, Louvain University, 2 Chemin du Cyclotron, 1348 Louvain-la-Neuve (Belgium); Yamauchi, Daisuke; Yokoyama, Jun' ichi [Research Center for the Early Universe (RESCEU), Graduate School of Science, The University of Tokyo, Tokyo 113-0033 (Japan); Bouchet, François R., E-mail: christophe.ringeval@uclouvain.be, E-mail: yamauchi@resceu.s.u-tokyo.ac.jp, E-mail: yokoyama@resceu.s.u-tokyo.ac.jp, E-mail: bouchet@iap.fr [Institut d' Astrophysique de Paris, UMR 7095-CNRS, Université Pierre et Marie Curie, 98bis boulevard Arago, 75014 Paris (France)

    2016-02-01

    Cosmic strings formed during inflation are expected to be either diluted over super-Hubble distances, i.e., invisible today, or to have crossed our past light cone very recently. We discuss the latter situation in which a few strings imprint their signature in the Cosmic Microwave Background (CMB) Anisotropies after recombination. Being almost frozen in the Hubble flow, these strings are quasi static and evade almost all of the previously derived constraints on their tension while being able to source large scale anisotropies in the CMB sky. Using a local variance estimator on thousand of numerically simulated Nambu-Goto all sky maps, we compute the expected signal and show that it can mimic a dipole modulation at large angular scales while being negligible at small angles. Interestingly, such a scenario generically produces one cold spot from the thawing of a cosmic string loop. Mixed with anisotropies of inflationary origin, we find that a few strings of tension GU = O(1) × 10{sup −6} match the amplitude of the dipole modulation reported in the Planck satellite measurements and could be at the origin of other large scale anomalies.

  6. Literature Review: Herbal Medicine Treatment after Large-Scale Disasters.

    Science.gov (United States)

    Takayama, Shin; Kaneko, Soichiro; Numata, Takehiro; Kamiya, Tetsuharu; Arita, Ryutaro; Saito, Natsumi; Kikuchi, Akiko; Ohsawa, Minoru; Kohayagawa, Yoshitaka; Ishii, Tadashi

    2017-01-01

    Large-scale natural disasters, such as earthquakes, tsunamis, volcanic eruptions, and typhoons, occur worldwide. After the Great East Japan earthquake and tsunami, our medical support operation's experiences suggested that traditional medicine might be useful for treating the various symptoms of the survivors. However, little information is available regarding herbal medicine treatment in such situations. Considering that further disasters will occur, we performed a literature review and summarized the traditional medicine approaches for treatment after large-scale disasters. We searched PubMed and Cochrane Library for articles written in English, and Ichushi for those written in Japanese. Articles published before 31 March 2016 were included. Keywords "disaster" and "herbal medicine" were used in our search. Among studies involving herbal medicine after a disaster, we found two randomized controlled trials investigating post-traumatic stress disorder (PTSD), three retrospective investigations of trauma or common diseases, and seven case series or case reports of dizziness, pain, and psychosomatic symptoms. In conclusion, herbal medicine has been used to treat trauma, PTSD, and other symptoms after disasters. However, few articles have been published, likely due to the difficulty in designing high quality studies in such situations. Further study will be needed to clarify the usefulness of herbal medicine after disasters.

  7. Development of large-scale functional brain networks in children.

    Directory of Open Access Journals (Sweden)

    Kaustubh Supekar

    2009-07-01

    Full Text Available The ontogeny of large-scale functional organization of the human brain is not well understood. Here we use network analysis of intrinsic functional connectivity to characterize the organization of brain networks in 23 children (ages 7-9 y and 22 young-adults (ages 19-22 y. Comparison of network properties, including path-length, clustering-coefficient, hierarchy, and regional connectivity, revealed that although children and young-adults' brains have similar "small-world" organization at the global level, they differ significantly in hierarchical organization and interregional connectivity. We found that subcortical areas were more strongly connected with primary sensory, association, and paralimbic areas in children, whereas young-adults showed stronger cortico-cortical connectivity between paralimbic, limbic, and association areas. Further, combined analysis of functional connectivity with wiring distance measures derived from white-matter fiber tracking revealed that the development of large-scale brain networks is characterized by weakening of short-range functional connectivity and strengthening of long-range functional connectivity. Importantly, our findings show that the dynamic process of over-connectivity followed by pruning, which rewires connectivity at the neuronal level, also operates at the systems level, helping to reconfigure and rebalance subcortical and paralimbic connectivity in the developing brain. Our study demonstrates the usefulness of network analysis of brain connectivity to elucidate key principles underlying functional brain maturation, paving the way for novel studies of disrupted brain connectivity in neurodevelopmental disorders such as autism.

  8. Development of large-scale functional brain networks in children.

    Science.gov (United States)

    Supekar, Kaustubh; Musen, Mark; Menon, Vinod

    2009-07-01

    The ontogeny of large-scale functional organization of the human brain is not well understood. Here we use network analysis of intrinsic functional connectivity to characterize the organization of brain networks in 23 children (ages 7-9 y) and 22 young-adults (ages 19-22 y). Comparison of network properties, including path-length, clustering-coefficient, hierarchy, and regional connectivity, revealed that although children and young-adults' brains have similar "small-world" organization at the global level, they differ significantly in hierarchical organization and interregional connectivity. We found that subcortical areas were more strongly connected with primary sensory, association, and paralimbic areas in children, whereas young-adults showed stronger cortico-cortical connectivity between paralimbic, limbic, and association areas. Further, combined analysis of functional connectivity with wiring distance measures derived from white-matter fiber tracking revealed that the development of large-scale brain networks is characterized by weakening of short-range functional connectivity and strengthening of long-range functional connectivity. Importantly, our findings show that the dynamic process of over-connectivity followed by pruning, which rewires connectivity at the neuronal level, also operates at the systems level, helping to reconfigure and rebalance subcortical and paralimbic connectivity in the developing brain. Our study demonstrates the usefulness of network analysis of brain connectivity to elucidate key principles underlying functional brain maturation, paving the way for novel studies of disrupted brain connectivity in neurodevelopmental disorders such as autism.

  9. Some ecological guidelines for large-scale biomass plantations

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, W.; Cook, J.H.; Beyea, J. [National Audubon Society, Tavernier, FL (United States)

    1993-12-31

    The National Audubon Society sees biomass as an appropriate and necessary source of energy to help replace fossil fuels in the near future, but is concerned that large-scale biomass plantations could displace significant natural vegetation and wildlife habitat, and reduce national and global biodiversity. We support the development of an industry large enough to provide significant portions of our energy budget, but we see a critical need to ensure that plantations are designed and sited in ways that minimize ecological disruption, or even provide environmental benefits. We have been studying the habitat value of intensively managed short-rotation tree plantations. Our results show that these plantations support large populations of some birds, but not all of the species using the surrounding landscape, and indicate that their value as habitat can be increased greatly by including small areas of mature trees within them. We believe short-rotation plantations can benefit regional biodiversity if they can be deployed as buffers for natural forests, or as corridors connecting forest tracts. To realize these benefits, and to avoid habitat degradation, regional biomass plantation complexes (e.g., the plantations supplying all the fuel for a powerplant) need to be planned, sited, and developed as large-scale units in the context of the regional landscape mosaic.

  10. Large Scale Cosmological Anomalies and Inhomogeneous Dark Energy

    Directory of Open Access Journals (Sweden)

    Leandros Perivolaropoulos

    2014-01-01

    Full Text Available A wide range of large scale observations hint towards possible modifications on the standard cosmological model which is based on a homogeneous and isotropic universe with a small cosmological constant and matter. These observations, also known as “cosmic anomalies” include unexpected Cosmic Microwave Background perturbations on large angular scales, large dipolar peculiar velocity flows of galaxies (“bulk flows”, the measurement of inhomogenous values of the fine structure constant on cosmological scales (“alpha dipole” and other effects. The presence of the observational anomalies could either be a large statistical fluctuation in the context of ΛCDM or it could indicate a non-trivial departure from the cosmological principle on Hubble scales. Such a departure is very much constrained by cosmological observations for matter. For dark energy however there are no significant observational constraints for Hubble scale inhomogeneities. In this brief review I discuss some of the theoretical models that can naturally lead to inhomogeneous dark energy, their observational constraints and their potential to explain the large scale cosmic anomalies.

  11. Glass badge dosimetry system for large scale personal monitoring

    International Nuclear Information System (INIS)

    Norimichi Juto

    2002-01-01

    Glass Badge using silver activated phosphate glass dosemeter was specially developed for large scale personal monitoring. And dosimetry systems such as an automatic leader and a dose equipment calculation algorithm were developed at once to achieve reasonable personal monitoring. In large scale personal monitoring, both of precision for dosimetry and confidence for lot of personal data handling become very important. The silver activated phosphate glass dosemeter has basically excellent characteristics for dosimetry such as homogeneous and stable sensitivity, negligible fading and so on. Glass Badge was designed to measure 10 keV - 10 MeV range of photon. 300 keV - 3 MeV range of beta, and 0.025 eV - 15 MeV range of neutron by included SSNTD. And developed Glass Badge dosimetry system has not only these basic characteristics but also lot of features to keep good precision for dosimetry and data handling. In this presentation, features of Glass Badge dosimetry systems and examples for practical personal monitoring systems will be presented. (Author)

  12. Extending SME to Handle Large-Scale Cognitive Modeling.

    Science.gov (United States)

    Forbus, Kenneth D; Ferguson, Ronald W; Lovett, Andrew; Gentner, Dedre

    2017-07-01

    Analogy and similarity are central phenomena in human cognition, involved in processes ranging from visual perception to conceptual change. To capture this centrality requires that a model of comparison must be able to integrate with other processes and handle the size and complexity of the representations required by the tasks being modeled. This paper describes extensions to Structure-Mapping Engine (SME) since its inception in 1986 that have increased its scope of operation. We first review the basic SME algorithm, describe psychological evidence for SME as a process model, and summarize its role in simulating similarity-based retrieval and generalization. Then we describe five techniques now incorporated into the SME that have enabled it to tackle large-scale modeling tasks: (a) Greedy merging rapidly constructs one or more best interpretations of a match in polynomial time: O(n 2 log(n)); (b) Incremental operation enables mappings to be extended as new information is retrieved or derived about the base or target, to model situations where information in a task is updated over time; (c) Ubiquitous predicates model the varying degrees to which items may suggest alignment; (d) Structural evaluation of analogical inferences models aspects of plausibility judgments; (e) Match filters enable large-scale task models to communicate constraints to SME to influence the mapping process. We illustrate via examples from published studies how these enable it to capture a broader range of psychological phenomena than before. Copyright © 2016 Cognitive Science Society, Inc.

  13. Exploiting Data Sparsity for Large-Scale Matrix Computations

    KAUST Repository

    Akbudak, Kadir

    2018-02-24

    Exploiting data sparsity in dense matrices is an algorithmic bridge between architectures that are increasingly memory-austere on a per-core basis and extreme-scale applications. The Hierarchical matrix Computations on Manycore Architectures (HiCMA) library tackles this challenging problem by achieving significant reductions in time to solution and memory footprint, while preserving a specified accuracy requirement of the application. HiCMA provides a high-performance implementation on distributed-memory systems of one of the most widely used matrix factorization in large-scale scientific applications, i.e., the Cholesky factorization. It employs the tile low-rank data format to compress the dense data-sparse off-diagonal tiles of the matrix. It then decomposes the matrix computations into interdependent tasks and relies on the dynamic runtime system StarPU for asynchronous out-of-order scheduling, while allowing high user-productivity. Performance comparisons and memory footprint on matrix dimensions up to eleven million show a performance gain and memory saving of more than an order of magnitude for both metrics on thousands of cores, against state-of-the-art open-source and vendor optimized numerical libraries. This represents an important milestone in enabling large-scale matrix computations toward solving big data problems in geospatial statistics for climate/weather forecasting applications.

  14. Large-scale impact cratering on the terrestrial planets

    International Nuclear Information System (INIS)

    Grieve, R.A.F.

    1982-01-01

    The crater densities on the earth and moon form the basis for a standard flux-time curve that can be used in dating unsampled planetary surfaces and constraining the temporal history of endogenic geologic processes. Abundant evidence is seen not only that impact cratering was an important surface process in planetary history but also that large imapact events produced effects that were crucial in scale. By way of example, it is noted that the formation of multiring basins on the early moon was as important in defining the planetary tectonic framework as plate tectonics is on the earth. Evidence from several planets suggests that the effects of very-large-scale impacts go beyond the simple formation of an impact structure and serve to localize increased endogenic activity over an extended period of geologic time. Even though no longer occurring with the frequency and magnitude of early solar system history, it is noted that large scale impact events continue to affect the local geology of the planets. 92 references

  15. Large scale and performance tests of the ATLAS online software

    International Nuclear Information System (INIS)

    Alexandrov; Kotov, V.; Mineev, M.; Roumiantsev, V.; Wolters, H.; Amorim, A.; Pedro, L.; Ribeiro, A.; Badescu, E.; Caprini, M.; Burckhart-Chromek, D.; Dobson, M.; Jones, R.; Kazarov, A.; Kolos, S.; Liko, D.; Lucio, L.; Mapelli, L.; Nassiakou, M.; Schweiger, D.; Soloviev, I.; Hart, R.; Ryabov, Y.; Moneta, L.

    2001-01-01

    One of the sub-systems of the Trigger/DAQ system of the future ATLAS experiment is the Online Software system. It encompasses the functionality needed to configure, control and monitor the DAQ. Its architecture is based on a component structure described in the ATLAS Trigger/DAQ technical proposal. Regular integration tests ensure its smooth operation in test beam setups during its evolutionary development towards the final ATLAS online system. Feedback is received and returned into the development process. Studies of the system behavior have been performed on a set of up to 111 PCs on a configuration which is getting closer to the final size. Large scale and performance test of the integrated system were performed on this setup with emphasis on investigating the aspects of the inter-dependence of the components and the performance of the communication software. Of particular interest were the run control state transitions in various configurations of the run control hierarchy. For the purpose of the tests, the software from other Trigger/DAQ sub-systems has been emulated. The author presents a brief overview of the online system structure, its components and the large scale integration tests and their results

  16. A convex optimization approach for solving large scale linear systems

    Directory of Open Access Journals (Sweden)

    Debora Cores

    2017-01-01

    Full Text Available The well-known Conjugate Gradient (CG method minimizes a strictly convex quadratic function for solving large-scale linear system of equations when the coefficient matrix is symmetric and positive definite. In this work we present and analyze a non-quadratic convex function for solving any large-scale linear system of equations regardless of the characteristics of the coefficient matrix. For finding the global minimizers, of this new convex function, any low-cost iterative optimization technique could be applied. In particular, we propose to use the low-cost globally convergent Spectral Projected Gradient (SPG method, which allow us to extend this optimization approach for solving consistent square and rectangular linear system, as well as linear feasibility problem, with and without convex constraints and with and without preconditioning strategies. Our numerical results indicate that the new scheme outperforms state-of-the-art iterative techniques for solving linear systems when the symmetric part of the coefficient matrix is indefinite, and also for solving linear feasibility problems.

  17. The combustion behavior of large scale lithium titanate battery

    Science.gov (United States)

    Huang, Peifeng; Wang, Qingsong; Li, Ke; Ping, Ping; Sun, Jinhua

    2015-01-01

    Safety problem is always a big obstacle for lithium battery marching to large scale application. However, the knowledge on the battery combustion behavior is limited. To investigate the combustion behavior of large scale lithium battery, three 50 Ah Li(NixCoyMnz)O2/Li4Ti5O12 batteries under different state of charge (SOC) were heated to fire. The flame size variation is depicted to analyze the combustion behavior directly. The mass loss rate, temperature and heat release rate are used to analyze the combustion behavior in reaction way deeply. Based on the phenomenon, the combustion process is divided into three basic stages, even more complicated at higher SOC with sudden smoke flow ejected. The reason is that a phase change occurs in Li(NixCoyMnz)O2 material from layer structure to spinel structure. The critical temperatures of ignition are at 112–121°C on anode tab and 139 to 147°C on upper surface for all cells. But the heating time and combustion time become shorter with the ascending of SOC. The results indicate that the battery fire hazard increases with the SOC. It is analyzed that the internal short and the Li+ distribution are the main causes that lead to the difference. PMID:25586064

  18. DEMNUni: massive neutrinos and the bispectrum of large scale structures

    Science.gov (United States)

    Ruggeri, Rossana; Castorina, Emanuele; Carbone, Carmelita; Sefusatti, Emiliano

    2018-03-01

    The main effect of massive neutrinos on the large-scale structure consists in a few percent suppression of matter perturbations on all scales below their free-streaming scale. Such effect is of particular importance as it allows to constraint the value of the sum of neutrino masses from measurements of the galaxy power spectrum. In this work, we present the first measurements of the next higher-order correlation function, the bispectrum, from N-body simulations that include massive neutrinos as particles. This is the simplest statistics characterising the non-Gaussian properties of the matter and dark matter halos distributions. We investigate, in the first place, the suppression due to massive neutrinos on the matter bispectrum, comparing our measurements with the simplest perturbation theory predictions, finding the approximation of neutrinos contributing at quadratic order in perturbation theory to provide a good fit to the measurements in the simulations. On the other hand, as expected, a linear approximation for neutrino perturbations would lead to Script O(fν) errors on the total matter bispectrum at large scales. We then attempt an extension of previous results on the universality of linear halo bias in neutrino cosmologies, to non-linear and non-local corrections finding consistent results with the power spectrum analysis.

  19. On the measurements of large scale solar velocity fields

    International Nuclear Information System (INIS)

    Andersen, B.N.

    1985-01-01

    A general mathematical formulation for the correction of the scattered light influence on solar Doppler shift measurements has been developed. This method has been applied to the straylight correction of measurements of solar rotation, limb effect, large scale flows and oscillations. It is shown that neglecting the straylight errors may cause spurious large scale velocity fields, oscillations and erronous values for the solar rotation and limb effect. The influence of active regions on full disc velocity measurements has been studied. It is shown that a 13 day periodicity in the global velocity signal will be introduced by the passage of sunspots over the solar disc. With different types of low resolution apertures, other periodicities may be introduced. Accurate measurements of the center-to-limb velocity shift are presented for a set of magnetic insensitive lines well suited for solar velocity measurements. The absolute wavelenght shifts are briefly discussed. The stronger lines have a ''supergravitational'' shift of 300-400 m/s at the solar limb. The results may be explained by the presence of a 20-25 m/s poleward meridional flow and a latitudinal dependence of the granular parameters. Using a simple model it is shown that the main properites of the observations are explained by a 5% increase in the granular size with latitude. Data presented indicate that the resonance line K I, 769.9 nm has a small but significant limb effect of 125 m/s from center to limb

  20. Nearly incompressible fluids: Hydrodynamics and large scale inhomogeneity

    International Nuclear Information System (INIS)

    Hunana, P.; Zank, G. P.; Shaikh, D.

    2006-01-01

    A system of hydrodynamic equations in the presence of large-scale inhomogeneities for a high plasma beta solar wind is derived. The theory is derived under the assumption of low turbulent Mach number and is developed for the flows where the usual incompressible description is not satisfactory and a full compressible treatment is too complex for any analytical studies. When the effects of compressibility are incorporated only weakly, a new description, referred to as 'nearly incompressible hydrodynamics', is obtained. The nearly incompressible theory, was originally applied to homogeneous flows. However, large-scale gradients in density, pressure, temperature, etc., are typical in the solar wind and it was unclear how inhomogeneities would affect the usual incompressible and nearly incompressible descriptions. In the homogeneous case, the lowest order expansion of the fully compressible equations leads to the usual incompressible equations, followed at higher orders by the nearly incompressible equations, as introduced by Zank and Matthaeus. With this work we show that the inclusion of large-scale inhomogeneities (in this case time-independent and radially symmetric background solar wind) modifies the leading-order incompressible description of solar wind flow. We find, for example, that the divergence of velocity fluctuations is nonsolenoidal and that density fluctuations can be described to leading order as a passive scalar. Locally (for small lengthscales), this system of equations converges to the usual incompressible equations and we therefore use the term 'locally incompressible' to describe the equations. This term should be distinguished from the term 'nearly incompressible', which is reserved for higher-order corrections. Furthermore, we find that density fluctuations scale with Mach number linearly, in contrast to the original homogeneous nearly incompressible theory, in which density fluctuations scale with the square of Mach number. Inhomogeneous nearly

  1. Nutrient removal from Chinese coastal waters by large-scale seaweed aquaculture

    KAUST Repository

    Xiao, Xi; Agusti, Susana; Lin, Fang; Li, Ke; Pan, Yaoru; Yu, Yan; Zheng, Yuhan; Wu, Jiaping; Duarte, Carlos M.

    2017-01-01

    China is facing intense coastal eutrophication. Large-scale seaweed aquaculture in China is popular, now accounting for over 2/3's of global production. Here, we estimate the nutrient removal capability of large-scale Chinese seaweed farms to determine its significance in mitigating eutrophication. We combined estimates of yield and nutrient concentration of Chinese seaweed aquaculture to quantify that one hectare of seaweed aquaculture removes the equivalent nutrient inputs entering 17.8 ha for nitrogen and 126.7 ha for phosphorus of Chinese coastal waters, respectively. Chinese seaweed aquaculture annually removes approximately 75,000 t nitrogen and 9,500 t phosphorus. Whereas removal of the total N inputs to Chinese coastal waters requires a seaweed farming area 17 times larger than the extant area, one and a half times more of the seaweed area would be able to remove close to 100% of the P inputs. With the current growth rate of seaweed aquaculture, we project this industry will remove 100% of the current phosphorus inputs to Chinese coastal waters by 2026. Hence, seaweed aquaculture already plays a hitherto unrealized role in mitigating coastal eutrophication, a role that may be greatly expanded with future growth of seaweed aquaculture.

  2. Nutrient removal from Chinese coastal waters by large-scale seaweed aquaculture

    KAUST Repository

    Xiao, Xi

    2017-04-21

    China is facing intense coastal eutrophication. Large-scale seaweed aquaculture in China is popular, now accounting for over 2/3\\'s of global production. Here, we estimate the nutrient removal capability of large-scale Chinese seaweed farms to determine its significance in mitigating eutrophication. We combined estimates of yield and nutrient concentration of Chinese seaweed aquaculture to quantify that one hectare of seaweed aquaculture removes the equivalent nutrient inputs entering 17.8 ha for nitrogen and 126.7 ha for phosphorus of Chinese coastal waters, respectively. Chinese seaweed aquaculture annually removes approximately 75,000 t nitrogen and 9,500 t phosphorus. Whereas removal of the total N inputs to Chinese coastal waters requires a seaweed farming area 17 times larger than the extant area, one and a half times more of the seaweed area would be able to remove close to 100% of the P inputs. With the current growth rate of seaweed aquaculture, we project this industry will remove 100% of the current phosphorus inputs to Chinese coastal waters by 2026. Hence, seaweed aquaculture already plays a hitherto unrealized role in mitigating coastal eutrophication, a role that may be greatly expanded with future growth of seaweed aquaculture.

  3. Randomised clinical trial: enteral nutrition does not improve the long-term outcome of alcoholic cirrhotic patients with jaundice.

    Science.gov (United States)

    Dupont, B; Dao, T; Joubert, C; Dupont-Lucas, C; Gloro, R; Nguyen-Khac, E; Beaujard, E; Mathurin, P; Vastel, E; Musikas, M; Ollivier, I; Piquet, M-A

    2012-05-01

    Malnutrition and jaundice are independent prognostic factors in cirrhosis. To assess the impact of enteral nutrition on the survival of alcoholic cirrhotic patients with jaundice but without acute alcoholic hepatitis. The study was a multicentre prospective randomised controlled trial comparing effects of enteral nutrition vs. a symptomatic support in patients with alcoholic cirrhosis and jaundice (bilirubin ≥51 µmol/L) but without severe acute alcoholic hepatitis. A total of 99 patients were randomised to receive either the conventional symptomatic treatment (55 patients) or the symptomatic support associated with 35 kcal/Kg/day of enteral nutrition during 4 weeks followed by an oral nutritional support during 2 months (44 patients). Randomisation was stratified on nutritional status. One-year survival curves were compared using the Kaplan-Meier method and Logrank test. Populations in both arms were similar. One-year survival was similar in the overall population (27/44 patients (61.4%) in the enteral nutrition arm vs. 36/55 (65.5%) in the control arm; Logrank P = 0.60) and in the subgroup suffering from malnutrition [18/29 patients (62.1%) in the enteral nutrition arm vs. 20/32 (62.5%) in the control arm; Logrank P = 0.99]. There was no statistical difference for bilirubin, prothrombin rate, Child-Pugh score, albumin or nutritional assessment. Complications during treatment (bleeding, encephalopathy, infection) occurred in 23% of patients in the enteral nutrition group (10/44) vs. 16% (9/55) of the control patients (P = 0.59). Enteral nutrition does not improve the survival and hepatic or nutritional parameters of cirrhotic patients with jaundice. © 2012 Blackwell Publishing Ltd.

  4. Large scale Brownian dynamics of confined suspensions of rigid particles

    Science.gov (United States)

    Sprinkle, Brennan; Balboa Usabiaga, Florencio; Patankar, Neelesh A.; Donev, Aleksandar

    2017-12-01

    We introduce methods for large-scale Brownian Dynamics (BD) simulation of many rigid particles of arbitrary shape suspended in a fluctuating fluid. Our method adds Brownian motion to the rigid multiblob method [F. Balboa Usabiaga et al., Commun. Appl. Math. Comput. Sci. 11(2), 217-296 (2016)] at a cost comparable to the cost of deterministic simulations. We demonstrate that we can efficiently generate deterministic and random displacements for many particles using preconditioned Krylov iterative methods, if kernel methods to efficiently compute the action of the Rotne-Prager-Yamakawa (RPY) mobility matrix and its "square" root are available for the given boundary conditions. These kernel operations can be computed with near linear scaling for periodic domains using the positively split Ewald method. Here we study particles partially confined by gravity above a no-slip bottom wall using a graphical processing unit implementation of the mobility matrix-vector product, combined with a preconditioned Lanczos iteration for generating Brownian displacements. We address a major challenge in large-scale BD simulations, capturing the stochastic drift term that arises because of the configuration-dependent mobility. Unlike the widely used Fixman midpoint scheme, our methods utilize random finite differences and do not require the solution of resistance problems or the computation of the action of the inverse square root of the RPY mobility matrix. We construct two temporal schemes which are viable for large-scale simulations, an Euler-Maruyama traction scheme and a trapezoidal slip scheme, which minimize the number of mobility problems to be solved per time step while capturing the required stochastic drift terms. We validate and compare these schemes numerically by modeling suspensions of boomerang-shaped particles sedimented near a bottom wall. Using the trapezoidal scheme, we investigate the steady-state active motion in dense suspensions of confined microrollers, whose

  5. The Effect of Large Scale Salinity Gradient on Langmuir Turbulence

    Science.gov (United States)

    Fan, Y.; Jarosz, E.; Yu, Z.; Jensen, T.; Sullivan, P. P.; Liang, J.

    2017-12-01

    Langmuir circulation (LC) is believed to be one of the leading order causes of turbulent mixing in the upper ocean. It is important for momentum and heat exchange across the mixed layer (ML) and directly impact the dynamics and thermodynamics in the upper ocean and lower atmosphere including the vertical distributions of chemical, biological, optical, and acoustic properties. Based on Craik and Leibovich (1976) theory, large eddy simulation (LES) models have been developed to simulate LC in the upper ocean, yielding new insights that could not be obtained from field observations and turbulent closure models. Due its high computational cost, LES models are usually limited to small domain sizes and cannot resolve large-scale flows. Furthermore, most LES models used in the LC simulations use periodic boundary conditions in the horizontal direction, which assumes the physical properties (i.e. temperature and salinity) and expected flow patterns in the area of interest are of a periodically repeating nature so that the limited small LES domain is representative for the larger area. Using periodic boundary condition can significantly reduce computational effort in problems, and it is a good assumption for isotropic shear turbulence. However, LC is anisotropic (McWilliams et al 1997) and was observed to be modulated by crosswind tidal currents (Kukulka et al 2011). Using symmetrical domains, idealized LES studies also indicate LC could interact with oceanic fronts (Hamlington et al 2014) and standing internal waves (Chini and Leibovich, 2005). The present study expands our previous LES modeling investigations of Langmuir turbulence to the real ocean conditions with large scale environmental motion that features fresh water inflow into the study region. Large scale gradient forcing is introduced to the NCAR LES model through scale separation analysis. The model is applied to a field observation in the Gulf of Mexico in July, 2016 when the measurement site was impacted by

  6. Self-* and Adaptive Mechanisms for Large Scale Distributed Systems

    Science.gov (United States)

    Fragopoulou, P.; Mastroianni, C.; Montero, R.; Andrjezak, A.; Kondo, D.

    Large-scale distributed computing systems and infrastructure, such as Grids, P2P systems and desktop Grid platforms, are decentralized, pervasive, and composed of a large number of autonomous entities. The complexity of these systems is such that human administration is nearly impossible and centralized or hierarchical control is highly inefficient. These systems need to run on highly dynamic environments, where content, network topologies and workloads are continuously changing. Moreover, they are characterized by the high degree of volatility of their components and the need to provide efficient service management and to handle efficiently large amounts of data. This paper describes some of the areas for which adaptation emerges as a key feature, namely, the management of computational Grids, the self-management of desktop Grid platforms and the monitoring and healing of complex applications. It also elaborates on the use of bio-inspired algorithms to achieve self-management. Related future trends and challenges are described.

  7. Complex modular structure of large-scale brain networks

    Science.gov (United States)

    Valencia, M.; Pastor, M. A.; Fernández-Seara, M. A.; Artieda, J.; Martinerie, J.; Chavez, M.

    2009-06-01

    Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large scale (voxel level) extracted from functional magnetic resonance imaging signals. By using a random-walk-based method, we unveil the modularity of brain webs and show modules with a spatial distribution that matches anatomical structures with functional significance. The functional role of each node in the network is studied by analyzing its patterns of inter- and intramodular connections. Results suggest that the modular architecture constitutes the structural basis for the coexistence of functional integration of distant and specialized brain areas during normal brain activities at rest.

  8. Participatory Design of Large-Scale Information Systems

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2008-01-01

    into a PD process model that (1) emphasizes PD experiments as transcending traditional prototyping by evaluating fully integrated systems exposed to real work practices; (2) incorporates improvisational change management including anticipated, emergent, and opportunity-based change; and (3) extends initial...... design and development into a sustained and ongoing stepwise implementation that constitutes an overall technology-driven organizational change. The process model is presented through a largescale PD experiment in the Danish healthcare sector. We reflect on our experiences from this experiment......In this article we discuss how to engage in large-scale information systems development by applying a participatory design (PD) approach that acknowledges the unique situated work practices conducted by the domain experts of modern organizations. We reconstruct the iterative prototyping approach...

  9. Large-scale additive manufacturing with bioinspired cellulosic materials.

    Science.gov (United States)

    Sanandiya, Naresh D; Vijay, Yadunund; Dimopoulou, Marina; Dritsas, Stylianos; Fernandez, Javier G

    2018-06-05

    Cellulose is the most abundant and broadly distributed organic compound and industrial by-product on Earth. However, despite decades of extensive research, the bottom-up use of cellulose to fabricate 3D objects is still plagued with problems that restrict its practical applications: derivatives with vast polluting effects, use in combination with plastics, lack of scalability and high production cost. Here we demonstrate the general use of cellulose to manufacture large 3D objects. Our approach diverges from the common association of cellulose with green plants and it is inspired by the wall of the fungus-like oomycetes, which is reproduced introducing small amounts of chitin between cellulose fibers. The resulting fungal-like adhesive material(s) (FLAM) are strong, lightweight and inexpensive, and can be molded or processed using woodworking techniques. We believe this first large-scale additive manufacture with ubiquitous biological polymers will be the catalyst for the transition to environmentally benign and circular manufacturing models.

  10. Large-scale experience with biological treatment of contaminated soil

    International Nuclear Information System (INIS)

    Schulz-Berendt, V.; Poetzsch, E.

    1995-01-01

    The efficiency of biological methods for the cleanup of soil contaminated with total petroleum hydrocarbons (TPH) and polycyclic aromatic hydrocarbons (PAH) was demonstrated by a large-scale example in which 38,000 tons of TPH- and PAH-polluted soil was treated onsite with the TERRAFERM reg-sign degradation system to reach the target values of 300 mg/kg TPH and 5 mg/kg PAH. Detection of the ecotoxicological potential (Microtox reg-sign assay) showed a significant decrease during the remediation. Low concentrations of PAH in the ground were treated by an in situ technology. The in situ treatment was combined with mechanical measures (slurry wall) to prevent the contamination from dispersing from the site

  11. Large scale sodium interactions. Part 1. Test facility design

    International Nuclear Information System (INIS)

    King, D.L.; Smaardyk, J.E.; Sallach, R.A.

    1977-01-01

    During the design of the test facility for large scale sodium interaction testing, an attempt was made to keep the system as simple and yet versatile as possible; therefore, a once through design was employed as opposed to any type of conventional sodium ''loop.'' The initial series of tests conducted at the facility call for rapidly dropping from 20 kg to 225 kg of sodium at temperatures from 825 0 K to 1125 0 K into concrete crucibles. The basic system layout is described. A commercial drum heater is used to melt the sodium which is in 55 gallon drums and then a slight argon pressurization is used to force the liquid sodium through a metallic filter and into a dump tank. Then the sodium dump tank is heated to the desired temperature. A diaphragm is mechanically ruptured and the sodium is dumped into a crucible that is housed inside a large steel test chamber

  12. Structural Quality of Service in Large-Scale Networks

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup

    , telephony and data. To meet the requirements of the different applications, and to handle the increased vulnerability to failures, the ability to design robust networks providing good Quality of Service is crucial. However, most planning of large-scale networks today is ad-hoc based, leading to highly...... complex networks lacking predictability and global structural properties. The thesis applies the concept of Structural Quality of Service to formulate desirable global properties, and it shows how regular graph structures can be used to obtain such properties.......Digitalization has created the base for co-existence and convergence in communications, leading to an increasing use of multi service networks. This is for example seen in the Fiber To The Home implementations, where a single fiber is used for virtually all means of communication, including TV...

  13. Performance Health Monitoring of Large-Scale Systems

    Energy Technology Data Exchange (ETDEWEB)

    Rajamony, Ram [IBM Research, Austin, TX (United States)

    2014-11-20

    This report details the progress made on the ASCR funded project Performance Health Monitoring for Large Scale Systems. A large-­scale application may not achieve its full performance potential due to degraded performance of even a single subsystem. Detecting performance faults, isolating them, and taking remedial action is critical for the scale of systems on the horizon. PHM aims to develop techniques and tools that can be used to identify and mitigate such performance problems. We accomplish this through two main aspects. The PHM framework encompasses diagnostics, system monitoring, fault isolation, and performance evaluation capabilities that indicates when a performance fault has been detected, either due to an anomaly present in the system itself or due to contention for shared resources between concurrently executing jobs. Software components called the PHM Control system then build upon the capabilities provided by the PHM framework to mitigate degradation caused by performance problems.

  14. Large-scale patterns in Rayleigh-Benard convection

    International Nuclear Information System (INIS)

    Hardenberg, J. von; Parodi, A.; Passoni, G.; Provenzale, A.; Spiegel, E.A.

    2008-01-01

    Rayleigh-Benard convection at large Rayleigh number is characterized by the presence of intense, vertically moving plumes. Both laboratory and numerical experiments reveal that the rising and descending plumes aggregate into separate clusters so as to produce large-scale updrafts and downdrafts. The horizontal scales of the aggregates reported so far have been comparable to the horizontal extent of the containers, but it has not been clear whether that represents a limitation imposed by domain size. In this work, we present numerical simulations of convection at sufficiently large aspect ratio to ascertain whether there is an intrinsic saturation scale for the clustering process when that ratio is large enough. From a series of simulations of Rayleigh-Benard convection with Rayleigh numbers between 10 5 and 10 8 and with aspect ratios up to 12π, we conclude that the clustering process has a finite horizontal saturation scale with at most a weak dependence on Rayleigh number in the range studied

  15. Hydrogen-combustion analyses of large-scale tests

    International Nuclear Information System (INIS)

    Gido, R.G.; Koestel, A.

    1986-01-01

    This report uses results of the large-scale tests with turbulence performed by the Electric Power Research Institute at the Nevada Test Site to evaluate hydrogen burn-analysis procedures based on lumped-parameter codes like COMPARE-H2 and associated burn-parameter models. The test results: (1) confirmed, in a general way, the procedures for application to pulsed burning, (2) increased significantly our understanding of the burn phenomenon by demonstrating that continuous burning can occur, and (3) indicated that steam can terminate continuous burning. Future actions recommended include: (1) modification of the code to perform continuous-burn analyses, which is demonstrated, (2) analyses to determine the type of burning (pulsed or continuous) that will exist in nuclear containments and the stable location if the burning is continuous, and (3) changes to the models for estimating burn parameters

  16. Hydrogen-combustion analyses of large-scale tests

    International Nuclear Information System (INIS)

    Gido, R.G.; Koestel, A.

    1986-01-01

    This report uses results of the large-scale tests with turbulence performed by the Electric Power Research Institute at the Nevada Test Site to evaluate hydrogen burn-analysis procedures based on lumped-parameter codes like COMPARE-H2 and associated burn-parameter models. The test results (a) confirmed, in a general way, the procedures for application to pulsed burning, (b) increased significantly our understanding of the burn phenomenon by demonstrating that continuous burning can occur and (c) indicated that steam can terminate continuous burning. Future actions recommended include (a) modification of the code to perform continuous-burn analyses, which is demonstrated, (b) analyses to determine the type of burning (pulsed or continuous) that will exist in nuclear containments and the stable location if the burning is continuous, and (c) changes to the models for estimating burn parameters

  17. Deep Feature Learning and Cascaded Classifier for Large Scale Data

    DEFF Research Database (Denmark)

    Prasoon, Adhish

    from data rather than having a predefined feature set. We explore deep learning approach of convolutional neural network (CNN) for segmenting three dimensional medical images. We propose a novel system integrating three 2D CNNs, which have a one-to-one association with the xy, yz and zx planes of 3D......This thesis focuses on voxel/pixel classification based approaches for image segmentation. The main application is segmentation of articular cartilage in knee MRIs. The first major contribution of the thesis deals with large scale machine learning problems. Many medical imaging problems need huge...... amount of training data to cover sufficient biological variability. Learning methods scaling badly with number of training data points cannot be used in such scenarios. This may restrict the usage of many powerful classifiers having excellent generalization ability. We propose a cascaded classifier which...

  18. Towards large-scale plasma-assisted synthesis of nanowires

    Science.gov (United States)

    Cvelbar, U.

    2011-05-01

    Large quantities of nanomaterials, e.g. nanowires (NWs), are needed to overcome the high market price of nanomaterials and make nanotechnology widely available for general public use and applications to numerous devices. Therefore, there is an enormous need for new methods or routes for synthesis of those nanostructures. Here plasma technologies for synthesis of NWs, nanotubes, nanoparticles or other nanostructures might play a key role in the near future. This paper presents a three-dimensional problem of large-scale synthesis connected with the time, quantity and quality of nanostructures. Herein, four different plasma methods for NW synthesis are presented in contrast to other methods, e.g. thermal processes, chemical vapour deposition or wet chemical processes. The pros and cons are discussed in detail for the case of two metal oxides: iron oxide and zinc oxide NWs, which are important for many applications.

  19. Large-scale visualization system for grid environment

    International Nuclear Information System (INIS)

    Suzuki, Yoshio

    2007-01-01

    Center for Computational Science and E-systems of Japan Atomic Energy Agency (CCSE/JAEA) has been conducting R and Ds of distributed computing (grid computing) environments: Seamless Thinking Aid (STA), Information Technology Based Laboratory (ITBL) and Atomic Energy Grid InfraStructure (AEGIS). In these R and Ds, we have developed the visualization technology suitable for the distributed computing environment. As one of the visualization tools, we have developed the Parallel Support Toolkit (PST) which can execute the visualization process parallely on a computer. Now, we improve PST to be executable simultaneously on multiple heterogeneous computers using Seamless Thinking Aid Message Passing Interface (STAMPI). STAMPI, we have developed in these R and Ds, is the MPI library executable on a heterogeneous computing environment. The improvement realizes the visualization of extremely large-scale data and enables more efficient visualization processes in a distributed computing environment. (author)

  20. Divergence of perturbation theory in large scale structures

    Science.gov (United States)

    Pajer, Enrico; van der Woude, Drian

    2018-05-01

    We make progress towards an analytical understanding of the regime of validity of perturbation theory for large scale structures and the nature of some non-perturbative corrections. We restrict ourselves to 1D gravitational collapse, for which exact solutions before shell crossing are known. We review the convergence of perturbation theory for the power spectrum, recently proven by McQuinn and White [1], and extend it to non-Gaussian initial conditions and the bispectrum. In contrast, we prove that perturbation theory diverges for the real space two-point correlation function and for the probability density function (PDF) of the density averaged in cells and all the cumulants derived from it. We attribute these divergences to the statistical averaging intrinsic to cosmological observables, which, even on very large and "perturbative" scales, gives non-vanishing weight to all extreme fluctuations. Finally, we discuss some general properties of non-perturbative effects in real space and Fourier space.

  1. BigSUR: large-scale structured urban reconstruction

    KAUST Repository

    Kelly, Tom; Femiani, John; Wonka, Peter; Mitra, Niloy J.

    2017-01-01

    The creation of high-quality semantically parsed 3D models for dense metropolitan areas is a fundamental urban modeling problem. Although recent advances in acquisition techniques and processing algorithms have resulted in large-scale imagery or 3D polygonal reconstructions, such data-sources are typically noisy, and incomplete, with no semantic structure. In this paper, we present an automatic data fusion technique that produces high-quality structured models of city blocks. From coarse polygonal meshes, street-level imagery, and GIS footprints, we formulate a binary integer program that globally balances sources of error to produce semantically parsed mass models with associated facade elements. We demonstrate our system on four city regions of varying complexity; our examples typically contain densely built urban blocks spanning hundreds of buildings. In our largest example, we produce a structured model of 37 city blocks spanning a total of 1,011 buildings at a scale and quality previously impossible to achieve automatically.

  2. Measuring large-scale social networks with high resolution.

    Directory of Open Access Journals (Sweden)

    Arkadiusz Stopczynski

    Full Text Available This paper describes the deployment of a large-scale study designed to measure human interactions across a variety of communication channels, with high temporal resolution and spanning multiple years-the Copenhagen Networks Study. Specifically, we collect data on face-to-face interactions, telecommunication, social networks, location, and background information (personality, demographics, health, politics for a densely connected population of 1000 individuals, using state-of-the-art smartphones as social sensors. Here we provide an overview of the related work and describe the motivation and research agenda driving the study. Additionally, the paper details the data-types measured, and the technical infrastructure in terms of both backend and phone software, as well as an outline of the deployment procedures. We document the participant privacy procedures and their underlying principles. The paper is concluded with early results from data analysis, illustrating the importance of multi-channel high-resolution approach to data collection.

  3. Large scale particle simulations in a virtual memory computer

    International Nuclear Information System (INIS)

    Gray, P.C.; Million, R.; Wagner, J.S.; Tajima, T.

    1983-01-01

    Virtual memory computers are capable of executing large-scale particle simulations even when the memory requirements exceeds the computer core size. The required address space is automatically mapped onto slow disc memory the the operating system. When the simulation size is very large, frequent random accesses to slow memory occur during the charge accumulation and particle pushing processes. Assesses to slow memory significantly reduce the excecution rate of the simulation. We demonstrate in this paper that with the proper choice of sorting algorithm, a nominal amount of sorting to keep physically adjacent particles near particles with neighboring array indices can reduce random access to slow memory, increase the efficiency of the I/O system, and hence, reduce the required computing time. (orig.)

  4. Policy Driven Development: Flexible Policy Insertion for Large Scale Systems.

    Science.gov (United States)

    Demchak, Barry; Krüger, Ingolf

    2012-07-01

    The success of a software system depends critically on how well it reflects and adapts to stakeholder requirements. Traditional development methods often frustrate stakeholders by creating long latencies between requirement articulation and system deployment, especially in large scale systems. One source of latency is the maintenance of policy decisions encoded directly into system workflows at development time, including those involving access control and feature set selection. We created the Policy Driven Development (PDD) methodology to address these development latencies by enabling the flexible injection of decision points into existing workflows at runtime , thus enabling policy composition that integrates requirements furnished by multiple, oblivious stakeholder groups. Using PDD, we designed and implemented a production cyberinfrastructure that demonstrates policy and workflow injection that quickly implements stakeholder requirements, including features not contemplated in the original system design. PDD provides a path to quickly and cost effectively evolve such applications over a long lifetime.

  5. Towards a 'standard model' of large scale structure formation

    International Nuclear Information System (INIS)

    Shafi, Q.

    1994-01-01

    We explore constraints on inflationary models employing data on large scale structure mainly from COBE temperature anisotropies and IRAS selected galaxy surveys. In models where the tensor contribution to the COBE signal is negligible, we find that the spectral index of density fluctuations n must exceed 0.7. Furthermore the COBE signal cannot be dominated by the tensor component, implying n > 0.85 in such models. The data favors cold plus hot dark matter models with n equal or close to unity and Ω HDM ∼ 0.2 - 0.35. Realistic grand unified theories, including supersymmetric versions, which produce inflation with these properties are presented. (author). 46 refs, 8 figs

  6. Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, Marcello [Univ. of Toronto, ON (Canada); Baldauf, T. [Inst. of Advanced Studies, Princeton, NJ (United States); Bond, J. Richard [Univ. of Toronto, ON (Canada); Canadian Inst. for Advanced Research, Toronto, ON (Canada); Dalal, N. [Univ. of Illinois, Urbana-Champaign, IL (United States); Putter, R. D. [Jet Propulsion Lab., Pasadena, CA (United States); California Inst. of Technology (CalTech), Pasadena, CA (United States); Dore, O. [Jet Propulsion Lab., Pasadena, CA (United States); California Inst. of Technology (CalTech), Pasadena, CA (United States); Green, Daniel [Univ. of Toronto, ON (Canada); Canadian Inst. for Advanced Research, Toronto, ON (Canada); Hirata, Chris [The Ohio State Univ., Columbus, OH (United States); Huang, Zhiqi [Univ. of Toronto, ON (Canada); Huterer, Dragan [Univ. of Michigan, Ann Arbor, MI (United States); Jeong, Donghui [Pennsylvania State Univ., University Park, PA (United States); Johnson, Matthew C. [York Univ., Toronto, ON (Canada); Perimeter Inst., Waterloo, ON (Canada); Krause, Elisabeth [Stanford Univ., CA (United States); Loverde, Marilena [Univ. of Chicago, IL (United States); Meyers, Joel [Univ. of Toronto, ON (Canada); Meeburg, Daniel [Univ. of Toronto, ON (Canada); Senatore, Leonardo [Stanford Univ., CA (United States); Shandera, Sarah [Pennsylvania State Univ., University Park, PA (United States); Silverstein, Eva [Stanford Univ., CA (United States); Slosar, Anze [Brookhaven National Lab. (BNL), Upton, NY (United States); Smith, Kendrick [Perimeter Inst., Waterloo, Toronto, ON (Canada); Zaldarriaga, Matias [Univ. of Toronto, ON (Canada); Assassi, Valentin [Cambridge Univ. (United Kingdom); Braden, Jonathan [Univ. of Toronto, ON (Canada); Hajian, Amir [Univ. of Toronto, ON (Canada); Kobayashi, Takeshi [Perimeter Inst., Waterloo, Toronto, ON (Canada); Univ. of Toronto, ON (Canada); Stein, George [Univ. of Toronto, ON (Canada); Engelen, Alexander van [Univ. of Toronto, ON (Canada)

    2014-12-15

    The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations. Large-scale structure is, however, from where drastic improvements should originate. In this paper, we explain the theoretical motivations for pursuing such measurements and the challenges that lie ahead. In particular, we discuss and identify theoretical targets regarding the measurement of primordial non-Gaussianity. We argue that when quantified in terms of the local (equilateral) template amplitude f$loc\\atop{NL}$ (f$eq\\atop{NL}$), natural target levels of sensitivity are Δf$loc, eq\\atop{NL}$ ≃ 1. We highlight that such levels are within reach of future surveys by measuring 2-, 3- and 4-point statistics of the galaxy spatial distribution. This paper summarizes a workshop held at CITA (University of Toronto) on October 23-24, 2014.

  7. Multidimensional quantum entanglement with large-scale integrated optics.

    Science.gov (United States)

    Wang, Jianwei; Paesani, Stefano; Ding, Yunhong; Santagati, Raffaele; Skrzypczyk, Paul; Salavrakos, Alexia; Tura, Jordi; Augusiak, Remigiusz; Mančinska, Laura; Bacco, Davide; Bonneau, Damien; Silverstone, Joshua W; Gong, Qihuang; Acín, Antonio; Rottwitt, Karsten; Oxenløwe, Leif K; O'Brien, Jeremy L; Laing, Anthony; Thompson, Mark G

    2018-04-20

    The ability to control multidimensional quantum systems is central to the development of advanced quantum technologies. We demonstrate a multidimensional integrated quantum photonic platform able to generate, control, and analyze high-dimensional entanglement. A programmable bipartite entangled system is realized with dimensions up to 15 × 15 on a large-scale silicon photonics quantum circuit. The device integrates more than 550 photonic components on a single chip, including 16 identical photon-pair sources. We verify the high precision, generality, and controllability of our multidimensional technology, and further exploit these abilities to demonstrate previously unexplored quantum applications, such as quantum randomness expansion and self-testing on multidimensional states. Our work provides an experimental platform for the development of multidimensional quantum technologies. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  8. Distributed system for large-scale remote research

    International Nuclear Information System (INIS)

    Ueshima, Yutaka

    2002-01-01

    In advanced photon research, large-scale simulations and high-resolution observations are powerfull tools. In numerical and real experiments, the real-time visualization and steering system is considered as a hopeful method of data analysis. This approach is valid in the typical analysis at one time or low cost experiment and simulation. In research of an unknown problem, it is necessary that the output data be analyzed many times because conclusive analysis is difficult at one time. Consequently, output data should be filed to refer and analyze at any time. To support research, we need the automatic functions, transporting data files from data generator to data storage, analyzing data, tracking history of data handling, and so on. The supporting system will be a functionally distributed system. (author)

  9. Large-scale dynamic compaction of natural salt

    International Nuclear Information System (INIS)

    Hansen, F.D.; Ahrens, E.H.

    1996-01-01

    A large-scale dynamic compaction demonstration of natural salt was successfully completed. About 40 m 3 of salt were compacted in three, 2-m lifts by dropping a 9,000-kg weight from a height of 15 m in a systematic pattern to achieve desired compaction energy. To enhance compaction, 1 wt% water was added to the relatively dry mine-run salt. The average compacted mass fractional density was 0.90 of natural intact salt, and in situ nitrogen permeabilities averaged 9X10 -14 m 2 . This established viability of dynamic compacting for placing salt shaft seal components. The demonstration also provided compacted salt parameters needed for shaft seal system design and performance assessments of the Waste Isolation Pilot Plant

  10. Large Scale GW Calculations on the Cori System

    Science.gov (United States)

    Deslippe, Jack; Del Ben, Mauro; da Jornada, Felipe; Canning, Andrew; Louie, Steven

    The NERSC Cori system, powered by 9000+ Intel Xeon-Phi processors, represents one of the largest HPC systems for open-science in the United States and the world. We discuss the optimization of the GW methodology for this system, including both node level and system-scale optimizations. We highlight multiple large scale (thousands of atoms) case studies and discuss both absolute application performance and comparison to calculations on more traditional HPC architectures. We find that the GW method is particularly well suited for many-core architectures due to the ability to exploit a large amount of parallelism across many layers of the system. This work was supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division, as part of the Computational Materials Sciences Program.

  11. Large-scale quantitative analysis of painting arts.

    Science.gov (United States)

    Kim, Daniel; Son, Seung-Woo; Jeong, Hawoong

    2014-12-11

    Scientists have made efforts to understand the beauty of painting art in their own languages. As digital image acquisition of painting arts has made rapid progress, researchers have come to a point where it is possible to perform statistical analysis of a large-scale database of artistic paints to make a bridge between art and science. Using digital image processing techniques, we investigate three quantitative measures of images - the usage of individual colors, the variety of colors, and the roughness of the brightness. We found a difference in color usage between classical paintings and photographs, and a significantly low color variety of the medieval period. Interestingly, moreover, the increment of roughness exponent as painting techniques such as chiaroscuro and sfumato have advanced is consistent with historical circumstances.

  12. Possible implications of large scale radiation processing of food

    International Nuclear Information System (INIS)

    Zagorski, Z.P.

    1990-01-01

    Large scale irradiation has been discussed in terms of the participation of processing cost in the final value of the improved product. Another factor has been taken into account and that is the saturation of the market with the new product. In the case of successful projects the participation of irradiation cost is low, and the demand for the better product is covered. A limited availability of sources makes the modest saturation of the market difficult with all food subjected to correct radiation treatment. The implementation of the preservation of food needs a decided selection of these kinds of food which comply to all conditions i.e. of acceptance by regulatory bodies, real improvement of quality and economy. The last condition prefers the possibility of use of electron beams of low energy. The best fulfilment of conditions for successful processing is observed in the group of dry food, in expensive spices in particular. (author)

  13. Bonus algorithm for large scale stochastic nonlinear programming problems

    CERN Document Server

    Diwekar, Urmila

    2015-01-01

    This book presents the details of the BONUS algorithm and its real world applications in areas like sensor placement in large scale drinking water networks, sensor placement in advanced power systems, water management in power systems, and capacity expansion of energy systems. A generalized method for stochastic nonlinear programming based on a sampling based approach for uncertainty analysis and statistical reweighting to obtain probability information is demonstrated in this book. Stochastic optimization problems are difficult to solve since they involve dealing with optimization and uncertainty loops. There are two fundamental approaches used to solve such problems. The first being the decomposition techniques and the second method identifies problem specific structures and transforms the problem into a deterministic nonlinear programming problem. These techniques have significant limitations on either the objective function type or the underlying distributions for the uncertain variables. Moreover, these ...

  14. Automatic Installation and Configuration for Large Scale Farms

    CERN Document Server

    Novák, J

    2005-01-01

    Since the early appearance of commodity hardware, the utilization of computers rose rapidly, and they became essential in all areas of life. Soon it was realized that nodes are able to work cooperatively, in order to solve new, more complex tasks. This conception got materialized in coherent aggregations of computers called farms and clusters. Collective application of nodes, being efficient and economical, was adopted in education, research and industry before long. But maintainance, especially in large scale, appeared as a problem to be resolved. New challenges needed new methods and tools. Development work has been started to build farm management applications and frameworks. In the first part of the thesis, these systems are introduced. After a general description of the matter, a comparative analysis of different approaches and tools illustrates the practical aspects of the theoretical discussion. CERN, the European Organization of Nuclear Research is the largest Particle Physics laboratory in the world....

  15. Preliminary design study of a large scale graphite oxidation loop

    International Nuclear Information System (INIS)

    Epel, L.G.; Majeski, S.J.; Schweitzer, D.G.; Sheehan, T.V.

    1979-08-01

    A preliminary design study of a large scale graphite oxidation loop was performed in order to assess feasibility and to estimate capital costs. The nominal design operates at 50 atmospheres helium and 1800 F with a graphite specimen 30 inches long and 10 inches in diameter. It was determined that a simple single walled design was not practical at this time because of a lack of commercially available thick walled high temperature alloys. Two alternative concepts, at reduced operating pressure, were investigated. Both were found to be readily fabricable to operate at 1800 F and capital cost estimates for these are included. A design concept, which is outside the scope of this study, was briefly considered

  16. Possible implications of large scale radiation processing of food

    Science.gov (United States)

    Zagórski, Z. P.

    Large scale irradiation has been discussed in terms of the participation of processing cost in the final value of the improved product. Another factor has been taken into account and that is the saturation of the market with the new product. In the case of succesful projects the participation of irradiation cost is low, and the demand for the better product is covered. A limited availability of sources makes the modest saturation of the market difficult with all food subjected to correct radiation treatment. The implementation of the preservation of food needs a decided selection of these kinds of food which comply to all conditions i.e. of acceptance by regulatory bodies, real improvement of quality and economy. The last condition prefers the possibility of use of electron beams of low energy. The best fullfilment of conditions for succesful processing is observed in the group of dry food, in expensive spices in particular.

  17. Coordinated SLNR based Precoding in Large-Scale Heterogeneous Networks

    KAUST Repository

    Boukhedimi, Ikram; Kammoun, Abla; Alouini, Mohamed-Slim

    2017-01-01

    This work focuses on the downlink of large-scale two-tier heterogeneous networks composed of a macro-cell overlaid by micro-cell networks. Our interest is on the design of coordinated beamforming techniques that allow to mitigate the inter-cell interference. Particularly, we consider the case in which the coordinating base stations (BSs) have imperfect knowledge of the channel state information. Under this setting, we propose a regularized SLNR based precoding design in which the regularization factor is used to allow better resilience with respect to the channel estimation errors. Based on tools from random matrix theory, we provide an analytical analysis of the SINR and SLNR performances. These results are then exploited to propose a proper setting of the regularization factor. Simulation results are finally provided in order to validate our findings and to confirm the performance of the proposed precoding scheme.

  18. BigSUR: large-scale structured urban reconstruction

    KAUST Repository

    Kelly, Tom

    2017-11-22

    The creation of high-quality semantically parsed 3D models for dense metropolitan areas is a fundamental urban modeling problem. Although recent advances in acquisition techniques and processing algorithms have resulted in large-scale imagery or 3D polygonal reconstructions, such data-sources are typically noisy, and incomplete, with no semantic structure. In this paper, we present an automatic data fusion technique that produces high-quality structured models of city blocks. From coarse polygonal meshes, street-level imagery, and GIS footprints, we formulate a binary integer program that globally balances sources of error to produce semantically parsed mass models with associated facade elements. We demonstrate our system on four city regions of varying complexity; our examples typically contain densely built urban blocks spanning hundreds of buildings. In our largest example, we produce a structured model of 37 city blocks spanning a total of 1,011 buildings at a scale and quality previously impossible to achieve automatically.

  19. Coordinated SLNR based Precoding in Large-Scale Heterogeneous Networks

    KAUST Repository

    Boukhedimi, Ikram

    2017-03-06

    This work focuses on the downlink of large-scale two-tier heterogeneous networks composed of a macro-cell overlaid by micro-cell networks. Our interest is on the design of coordinated beamforming techniques that allow to mitigate the inter-cell interference. Particularly, we consider the case in which the coordinating base stations (BSs) have imperfect knowledge of the channel state information. Under this setting, we propose a regularized SLNR based precoding design in which the regularization factor is used to allow better resilience with respect to the channel estimation errors. Based on tools from random matrix theory, we provide an analytical analysis of the SINR and SLNR performances. These results are then exploited to propose a proper setting of the regularization factor. Simulation results are finally provided in order to validate our findings and to confirm the performance of the proposed precoding scheme.

  20. Planning under uncertainty solving large-scale stochastic linear programs

    Energy Technology Data Exchange (ETDEWEB)

    Infanger, G. [Stanford Univ., CA (United States). Dept. of Operations Research]|[Technische Univ., Vienna (Austria). Inst. fuer Energiewirtschaft

    1992-12-01

    For many practical problems, solutions obtained from deterministic models are unsatisfactory because they fail to hedge against certain contingencies that may occur in the future. Stochastic models address this shortcoming, but up to recently seemed to be intractable due to their size. Recent advances both in solution algorithms and in computer technology now allow us to solve important and general classes of practical stochastic problems. We show how large-scale stochastic linear programs can be efficiently solved by combining classical decomposition and Monte Carlo (importance) sampling techniques. We discuss the methodology for solving two-stage stochastic linear programs with recourse, present numerical results of large problems with numerous stochastic parameters, show how to efficiently implement the methodology on a parallel multi-computer and derive the theory for solving a general class of multi-stage problems with dependency of the stochastic parameters within a stage and between different stages.

  1. Challenges and options for large scale integration of wind power

    International Nuclear Information System (INIS)

    Tande, John Olav Giaever

    2006-01-01

    Challenges and options for large scale integration of wind power are examined. Immediate challenges are related to weak grids. Assessment of system stability requires numerical simulation. Models are being developed - validation is essential. Coordination of wind and hydro generation is a key for allowing more wind power capacity in areas with limited transmission corridors. For the case study grid depending on technology and control the allowed wind farm size is increased from 50 to 200 MW. The real life example from 8 January 2005 demonstrates that existing marked based mechanisms can handle large amounts of wind power. In wind integration studies it is essential to take account of the controllability of modern wind farms, the power system flexibility and the smoothing effect of geographically dispersed wind farms. Modern wind farms contribute to system adequacy - combining wind and hydro constitutes a win-win system (ml)

  2. Hierarchical optimal control of large-scale nonlinear chemical processes.

    Science.gov (United States)

    Ramezani, Mohammad Hossein; Sadati, Nasser

    2009-01-01

    In this paper, a new approach is presented for optimal control of large-scale chemical processes. In this approach, the chemical process is decomposed into smaller sub-systems at the first level, and a coordinator at the second level, for which a two-level hierarchical control strategy is designed. For this purpose, each sub-system in the first level can be solved separately, by using any conventional optimization algorithm. In the second level, the solutions obtained from the first level are coordinated using a new gradient-type strategy, which is updated by the error of the coordination vector. The proposed algorithm is used to solve the optimal control problem of a complex nonlinear chemical stirred tank reactor (CSTR), where its solution is also compared with the ones obtained using the centralized approach. The simulation results show the efficiency and the capability of the proposed hierarchical approach, in finding the optimal solution, over the centralized method.

  3. Experimental Investigation of Large-Scale Bubbly Plumes

    Energy Technology Data Exchange (ETDEWEB)

    Zboray, R.; Simiano, M.; De Cachard, F

    2004-03-01

    Carefully planned and instrumented experiments under well-defined boundary conditions have been carried out on large-scale, isothermal, bubbly plumes. The data obtained is meant to validate newly developed, high-resolution numerical tools for 3D transient, two-phase flow modelling. Several measurement techniques have been utilised to collect data from the experiments: particle image velocimetry, optical probes, electromagnetic probes, and visualisation. Bubble and liquid velocity fields, void-fraction distributions, bubble size and interfacial-area-concentration distributions have all been measured in the plume region, as well as recirculation velocities in the surrounding pool. The results obtained from the different measurement techniques have been compared. In general, the two-phase flow data obtained from the different techniques are found to be consistent, and of high enough quality for validating numerical simulation tools for 3D bubbly flows. (author)

  4. Lightweight computational steering of very large scale molecular dynamics simulations

    International Nuclear Information System (INIS)

    Beazley, D.M.

    1996-01-01

    We present a computational steering approach for controlling, analyzing, and visualizing very large scale molecular dynamics simulations involving tens to hundreds of millions of atoms. Our approach relies on extensible scripting languages and an easy to use tool for building extensions and modules. The system is extremely easy to modify, works with existing C code, is memory efficient, and can be used from inexpensive workstations and networks. We demonstrate how we have used this system to manipulate data from production MD simulations involving as many as 104 million atoms running on the CM-5 and Cray T3D. We also show how this approach can be used to build systems that integrate common scripting languages (including Tcl/Tk, Perl, and Python), simulation code, user extensions, and commercial data analysis packages

  5. Geophysical mapping of complex glaciogenic large-scale structures

    DEFF Research Database (Denmark)

    Høyer, Anne-Sophie

    2013-01-01

    This thesis presents the main results of a four year PhD study concerning the use of geophysical data in geological mapping. The study is related to the Geocenter project, “KOMPLEKS”, which focuses on the mapping of complex, large-scale geological structures. The study area is approximately 100 km2...... data types and co-interpret them in order to improve our geological understanding. However, in order to perform this successfully, methodological considerations are necessary. For instance, a structure indicated by a reflection in the seismic data is not always apparent in the resistivity data...... information) can be collected. The geophysical data are used together with geological analyses from boreholes and pits to interpret the geological history of the hill-island. The geophysical data reveal that the glaciotectonic structures truncate at the surface. The directions of the structures were mapped...

  6. Large-scale transport across narrow gaps in rod bundles

    Energy Technology Data Exchange (ETDEWEB)

    Guellouz, M.S.; Tavoularis, S. [Univ. of Ottawa (Canada)

    1995-09-01

    Flow visualization and how-wire anemometry were used to investigate the velocity field in a rectangular channel containing a single cylindrical rod, which could be traversed on the centreplane to form gaps of different widths with the plane wall. The presence of large-scale, quasi-periodic structures in the vicinity of the gap has been demonstrated through flow visualization, spectral analysis and space-time correlation measurements. These structures are seen to exist even for relatively large gaps, at least up to W/D=1.350 (W is the sum of the rod diameter, D, and the gap width). The above measurements appear to compatible with the field of a street of three-dimensional, counter-rotating vortices, whose detailed structure, however, remains to be determined. The convection speed and the streamwise spacing of these vortices have been determined as functions of the gap size.

  7. Using Large Scale Test Results for Pedagogical Purposes

    DEFF Research Database (Denmark)

    Dolin, Jens

    2012-01-01

    The use and influence of large scale tests (LST), both national and international, has increased dramatically within the last decade. This process has revealed a tension between the legitimate need for information about the performance of the educational system and teachers to inform policy......, and the teachers’ and students’ use of this information for pedagogical purposes in the classroom. We know well how the policy makers interpret and use the outcomes of such tests, but we know less about how teachers make use of LSTs to inform their pedagogical practice. An important question is whether...... there is a contradiction between the political system’s use of LST and teachers’ (possible) pedagogical use of LST. And if yes: What is a contradiction based on? This presentation will give some results from a systematic review on how tests have influenced the pedagogical practice. The research revealed many of the fatal...

  8. Including investment risk in large-scale power market models

    DEFF Research Database (Denmark)

    Lemming, Jørgen Kjærgaard; Meibom, P.

    2003-01-01

    Long-term energy market models can be used to examine investments in production technologies, however, with market liberalisation it is crucial that such models include investment risks and investor behaviour. This paper analyses how the effect of investment risk on production technology selection...... can be included in large-scale partial equilibrium models of the power market. The analyses are divided into a part about risk measures appropriate for power market investors and a more technical part about the combination of a risk-adjustment model and a partial-equilibrium model. To illustrate...... the analyses quantitatively, a framework based on an iterative interaction between the equilibrium model and a separate risk-adjustment module was constructed. To illustrate the features of the proposed modelling approach we examined how uncertainty in demand and variable costs affects the optimal choice...

  9. Optimal Wind Energy Integration in Large-Scale Electric Grids

    Science.gov (United States)

    Albaijat, Mohammad H.

    The major concern in electric grid operation is operating under the most economical and reliable fashion to ensure affordability and continuity of electricity supply. This dissertation investigates the effects of such challenges, which affect electric grid reliability and economic operations. These challenges are: 1. Congestion of transmission lines, 2. Transmission lines expansion, 3. Large-scale wind energy integration, and 4. Phaser Measurement Units (PMUs) optimal placement for highest electric grid observability. Performing congestion analysis aids in evaluating the required increase of transmission line capacity in electric grids. However, it is necessary to evaluate expansion of transmission line capacity on methods to ensure optimal electric grid operation. Therefore, the expansion of transmission line capacity must enable grid operators to provide low-cost electricity while maintaining reliable operation of the electric grid. Because congestion affects the reliability of delivering power and increases its cost, the congestion analysis in electric grid networks is an important subject. Consequently, next-generation electric grids require novel methodologies for studying and managing congestion in electric grids. We suggest a novel method of long-term congestion management in large-scale electric grids. Owing to the complication and size of transmission line systems and the competitive nature of current grid operation, it is important for electric grid operators to determine how many transmission lines capacity to add. Traditional questions requiring answers are "Where" to add, "How much of transmission line capacity" to add, and "Which voltage level". Because of electric grid deregulation, transmission lines expansion is more complicated as it is now open to investors, whose main interest is to generate revenue, to build new transmission lines. Adding a new transmission capacity will help the system to relieve the transmission system congestion, create

  10. Electric vehicles and large-scale integration of wind power

    DEFF Research Database (Denmark)

    Liu, Wen; Hu, Weihao; Lund, Henrik

    2013-01-01

    with this imbalance and to reduce its high dependence on oil production. For this reason, it is interesting to analyse the extent to which transport electrification can further the renewable energy integration. This paper quantifies this issue in Inner Mongolia, where the share of wind power in the electricity supply...... was 6.5% in 2009 and which has the plan to develop large-scale wind power. The results show that electric vehicles (EVs) have the ability to balance the electricity demand and supply and to further the wind power integration. In the best case, the energy system with EV can increase wind power...... integration by 8%. The application of EVs benefits from saving both energy system cost and fuel cost. However, the negative consequences of decreasing energy system efficiency and increasing the CO2 emission should be noted when applying the hydrogen fuel cell vehicle (HFCV). The results also indicate...

  11. Experimental Investigation of Large-Scale Bubbly Plumes

    International Nuclear Information System (INIS)

    Zboray, R.; Simiano, M.; De Cachard, F.

    2004-01-01

    Carefully planned and instrumented experiments under well-defined boundary conditions have been carried out on large-scale, isothermal, bubbly plumes. The data obtained is meant to validate newly developed, high-resolution numerical tools for 3D transient, two-phase flow modelling. Several measurement techniques have been utilised to collect data from the experiments: particle image velocimetry, optical probes, electromagnetic probes, and visualisation. Bubble and liquid velocity fields, void-fraction distributions, bubble size and interfacial-area-concentration distributions have all been measured in the plume region, as well as recirculation velocities in the surrounding pool. The results obtained from the different measurement techniques have been compared. In general, the two-phase flow data obtained from the different techniques are found to be consistent, and of high enough quality for validating numerical simulation tools for 3D bubbly flows. (author)

  12. Complex Formation Control of Large-Scale Intelligent Autonomous Vehicles

    Directory of Open Access Journals (Sweden)

    Ming Lei

    2012-01-01

    Full Text Available A new formation framework of large-scale intelligent autonomous vehicles is developed, which can realize complex formations while reducing data exchange. Using the proposed hierarchy formation method and the automatic dividing algorithm, vehicles are automatically divided into leaders and followers by exchanging information via wireless network at initial time. Then, leaders form formation geometric shape by global formation information and followers track their own virtual leaders to form line formation by local information. The formation control laws of leaders and followers are designed based on consensus algorithms. Moreover, collision-avoiding problems are considered and solved using artificial potential functions. Finally, a simulation example that consists of 25 vehicles shows the effectiveness of theory.

  13. Safeguarding of large scale reprocessing and MOX plants

    International Nuclear Information System (INIS)

    Howsley, R.; Burrows, B.; Longevialle, H. de; Kuroi, H.; Izumi, A.

    1997-01-01

    In May 97, the IAEA Board of Governors approved the final measures of the ''93+2'' safeguards strengthening programme, thus improving the international non-proliferation regime by enhancing the effectiveness and efficiency of safeguards verification. These enhancements are not however, a revolution in current practices, but rather an important step in the continuous evolution of the safeguards system. The principles embodied in 93+2, for broader access to information and increased physical access already apply, in a pragmatic way, to large scale reprocessing and MOX fabrication plants. In these plants, qualitative measures and process monitoring play an important role in addition to accountancy and material balance evaluations in attaining the safeguard's goals. This paper will reflect on the safeguards approaches adopted for these large bulk handling facilities and draw analogies, conclusions and lessons for the forthcoming implementation of the 93+2 Programme. (author)

  14. Magnetic Properties of Large-Scale Nanostructured Graphene Systems

    DEFF Research Database (Denmark)

    Gregersen, Søren Schou

    The on-going progress in two-dimensional (2D) materials and nanostructure fabrication motivates the study of altered and combined materials. Graphene—the most studied material of the 2D family—displays unique electronic and spintronic properties. Exceptionally high electron mobilities, that surpass...... those in conventional materials such as silicon, make graphene a very interesting material for high-speed electronics. Simultaneously, long spin-diffusion lengths and spin-life times makes graphene an eligible spin-transport channel. In this thesis, we explore fundamental features of nanostructured...... graphene systems using large-scale modeling techniques. Graphene perforations, or antidots, have received substantial interest in the prospect of opening large band gaps in the otherwise gapless graphene. Motivated by recent improvements of fabrication processes, such as forming graphene antidots and layer...

  15. Segmentation by Large Scale Hypothesis Testing - Segmentation as Outlier Detection

    DEFF Research Database (Denmark)

    Darkner, Sune; Dahl, Anders Lindbjerg; Larsen, Rasmus

    2010-01-01

    a microscope and we show how the method can handle transparent particles with significant glare point. The method generalizes to other problems. THis is illustrated by applying the method to camera calibration images and MRI of the midsagittal plane for gray and white matter separation and segmentation......We propose a novel and efficient way of performing local image segmentation. For many applications a threshold of pixel intensities is sufficient but determine the appropriate threshold value can be difficult. In cases with large global intensity variation the threshold value has to be adapted...... locally. We propose a method based on large scale hypothesis testing with a consistent method for selecting an appropriate threshold for the given data. By estimating the background distribution we characterize the segment of interest as a set of outliers with a certain probability based on the estimated...

  16. A large-scale computer facility for computational aerodynamics

    International Nuclear Information System (INIS)

    Bailey, F.R.; Balhaus, W.F.

    1985-01-01

    The combination of computer system technology and numerical modeling have advanced to the point that computational aerodynamics has emerged as an essential element in aerospace vehicle design methodology. To provide for further advances in modeling of aerodynamic flow fields, NASA has initiated at the Ames Research Center the Numerical Aerodynamic Simulation (NAS) Program. The objective of the Program is to develop a leading-edge, large-scale computer facility, and make it available to NASA, DoD, other Government agencies, industry and universities as a necessary element in ensuring continuing leadership in computational aerodynamics and related disciplines. The Program will establish an initial operational capability in 1986 and systematically enhance that capability by incorporating evolving improvements in state-of-the-art computer system technologies as required to maintain a leadership role. This paper briefly reviews the present and future requirements for computational aerodynamics and discusses the Numerical Aerodynamic Simulation Program objectives, computational goals, and implementation plans

  17. Exploiting large-scale correlations to detect continuous gravitational waves.

    Science.gov (United States)

    Pletsch, Holger J; Allen, Bruce

    2009-10-30

    Fully coherent searches (over realistic ranges of parameter space and year-long observation times) for unknown sources of continuous gravitational waves are computationally prohibitive. Less expensive hierarchical searches divide the data into shorter segments which are analyzed coherently, then detection statistics from different segments are combined incoherently. The novel method presented here solves the long-standing problem of how best to do the incoherent combination. The optimal solution exploits large-scale parameter-space correlations in the coherent detection statistic. Application to simulated data shows dramatic sensitivity improvements compared with previously available (ad hoc) methods, increasing the spatial volume probed by more than 2 orders of magnitude at lower computational cost.

  18. Large scale intender test program to measure sub gouge displacements

    Energy Technology Data Exchange (ETDEWEB)

    Been, Ken; Lopez, Juan [Golder Associates Inc, Houston, TX (United States); Sancio, Rodolfo [MMI Engineering Inc., Houston, TX (United States)

    2011-07-01

    The production of submarine pipelines in an offshore environment covered with ice is very challenging. Several precautions must be taken such as burying the pipelines to protect them from ice movement caused by gouging. The estimation of the subgouge displacements is a key factor in pipeline design for ice gouged environments. This paper investigated a method to measure subgouge displacements. An experimental program was implemented in an open field to produce large scale idealized gouges on engineered soil beds (sand and clay). The horizontal force required to produce the gouge, the subgouge displacements in the soil and the strain imposed by these displacements were monitored on a buried model pipeline. The results showed that for a given keel, the gouge depth was inversely proportional to undrained shear strength in clay. The subgouge displacements measured did not show a relationship with the gouge depth, width or soil density in sand and clay tests.

  19. Cosmological perturbations from quantum fluctuations to large scale structure

    International Nuclear Information System (INIS)

    Bardeen, J.M.

    1988-01-01

    Classical perturbation theory is developed from the 3 + 1 form of the Einstein equations. A somewhat unusual form of the perturbation equations in the synchronous gauge is recommended for carrying out computations, but interpretation is based on certain hypersurface-invariant combinations of the variables. The formalism is used to analyze the origin of density perturbations from quantum fluctuations during inflation, with particular emphasis on dealing with 'double inflation' and deviations from the Zel'dovich spectrum. The evolution of the density perturbation to the present gives the final density perturbation power spectrum, whose relationship to observed large scale structure is discussed in the context of simple cold-dark-matter biasing schemes. 86 refs

  20. Large-scale Ising-machines composed of magnetic neurons

    Science.gov (United States)

    Mizushima, Koichi; Goto, Hayato; Sato, Rie

    2017-10-01

    We propose Ising-machines composed of magnetic neurons, that is, magnetic bits in a recording track. In large-scale machines, the sizes of both neurons and synapses need to be reduced, and neat and smart connections among neurons are also required to achieve all-to-all connectivity among them. These requirements can be fulfilled by adopting magnetic recording technologies such as race-track memories and skyrmion tracks because the area of a magnetic bit is almost two orders of magnitude smaller than that of static random access memory, which has normally been used as a semiconductor neuron, and the smart connections among neurons are realized by using the read and write methods of these technologies.

  1. Large scale computing in theoretical physics: Example QCD

    International Nuclear Information System (INIS)

    Schilling, K.

    1986-01-01

    The limitations of the classical mathematical analysis of Newton and Leibniz appear to be more and more overcome by the power of modern computers. Large scale computing techniques - which resemble closely the methods used in simulations within statistical mechanics - allow to treat nonlinear systems with many degrees of freedom such as field theories in nonperturbative situations, where analytical methods do fail. The computation of the hadron spectrum within the framework of lattice QCD sets a demanding goal for the application of supercomputers in basic science. It requires both big computer capacities and clever algorithms to fight all the numerical evils that one encounters in the Euclidean world. The talk will attempt to describe both the computer aspects and the present state of the art of spectrum calculations within lattice QCD. (orig.)

  2. SIMON: Remote collaboration system based on large scale simulation

    International Nuclear Information System (INIS)

    Sugawara, Akihiro; Kishimoto, Yasuaki

    2003-01-01

    Development of SIMON (SImulation MONitoring) system is described. SIMON aims to investigate many physical phenomena of tokamak type nuclear fusion plasma by simulation and to exchange information and to carry out joint researches with scientists in the world using internet. The characteristics of SIMON are followings; 1) decrease load of simulation by trigger sending method, 2) visualization of simulation results and hierarchical structure of analysis, 3) decrease of number of license by using command line when software is used, 4) improvement of support for using network of simulation data output by use of HTML (Hyper Text Markup Language), 5) avoidance of complex built-in work in client part and 6) small-sized and portable software. The visualization method of large scale simulation, remote collaboration system by HTML, trigger sending method, hierarchical analytical method, introduction into three-dimensional electromagnetic transportation code and technologies of SIMON system are explained. (S.Y.)

  3. Large-scale demonstration of waste solidification in saltstone

    International Nuclear Information System (INIS)

    McIntyre, P.F.; Oblath, S.B.; Wilhite, E.L.

    1988-05-01

    The saltstone lysimeters are a large scale demonstration of a disposal concept for decontaminated salt solution resulting from in-tank processing of defense waste. The lysimeter experiment has provided data on the leaching behavior of large saltstone monoliths under realistic field conditions. The results also will be used to compare the effect of capping the wasteform on contaminant release. Biweekly monitoring of sump leachate from three lysimeters has continued on a routine basis for approximately 3 years. An uncapped lysimeter has shown the highest levels of nitrate and 99 Tc release. Gravel and clay capped lysimeters have shown levels equivalent to or slightly higher than background rainwater levels. Mathematical model predictions have been compared to lysimeter results. The models will be applied to predict the impact of saltstone disposal on groundwater quality. 9 refs., 5 figs., 3 tabs

  4. Combined process automation for large-scale EEG analysis.

    Science.gov (United States)

    Sfondouris, John L; Quebedeaux, Tabitha M; Holdgraf, Chris; Musto, Alberto E

    2012-01-01

    Epileptogenesis is a dynamic process producing increased seizure susceptibility. Electroencephalography (EEG) data provides information critical in understanding the evolution of epileptiform changes throughout epileptic foci. We designed an algorithm to facilitate efficient large-scale EEG analysis via linked automation of multiple data processing steps. Using EEG recordings obtained from electrical stimulation studies, the following steps of EEG analysis were automated: (1) alignment and isolation of pre- and post-stimulation intervals, (2) generation of user-defined band frequency waveforms, (3) spike-sorting, (4) quantification of spike and burst data and (5) power spectral density analysis. This algorithm allows for quicker, more efficient EEG analysis. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Decomposition of residual oil by large scale HSC plant

    Energy Technology Data Exchange (ETDEWEB)

    Washimi, Koichi; Ogata, Yoshitaka; Limmer, H.; Schuetter, H. (Toyo Engineering Corp., funabashi, Japan VEB Petrolchemisches Kombinat Schwedt, Schwedt (East Germany))

    1989-07-01

    Regarding large scale and high decomposition ratio visbreaker HSC, characteristic points and operation conditions of a new plant in East Germany were introduced. As for the characteristics of the process, high decomposition ratio and stable decpmposed oil, availability of high sulfur content oil or even decomposed residuum of visbreaker, stableness of produced light oil with low content of unsaturated components, low investment with low running cost, were indicated. For the realization of high decomposition ratio, designing for suppressing the decomposition in heating furnace and accelaration of it in soaking drum, high space velocity of gas phase for better agitation, were raised. As the main subject of technical development, design of soaking drum was indicated with main dimensions for the designing. Operation conditions of the process in East Germany using residual oil supplied from already working visbreaker for USSR crude oil were introduced. 6 refs., 4 figs., 2 tabs.

  6. Matrix Sampling of Items in Large-Scale Assessments

    Directory of Open Access Journals (Sweden)

    Ruth A. Childs

    2003-07-01

    Full Text Available Matrix sampling of items -' that is, division of a set of items into different versions of a test form..-' is used by several large-scale testing programs. Like other test designs, matrixed designs have..both advantages and disadvantages. For example, testing time per student is less than if each..student received all the items, but the comparability of student scores may decrease. Also,..curriculum coverage is maintained, but reporting of scores becomes more complex. In this paper,..matrixed designs are compared with more traditional designs in nine categories of costs:..development costs, materials costs, administration costs, educational costs, scoring costs,..reliability costs, comparability costs, validity costs, and reporting costs. In choosing among test..designs, a testing program should examine the costs in light of its mandate(s, the content of the..tests, and the financial resources available, among other considerations.

  7. Nuclear-pumped lasers for large-scale applications

    International Nuclear Information System (INIS)

    Anderson, R.E.; Leonard, E.M.; Shea, R.F.; Berggren, R.R.

    1989-05-01

    Efficient initiation of large-volume chemical lasers may be achieved by neutron induced reactions which produce charged particles in the final state. When a burst mode nuclear reactor is used as the neutron source, both a sufficiently intense neutron flux and a sufficiently short initiation pulse may be possible. Proof-of-principle experiments are planned to demonstrate lasing in a direct nuclear-pumped large-volume system; to study the effects of various neutron absorbing materials on laser performance; to study the effects of long initiation pulse lengths; to demonstrate the performance of large-scale optics and the beam quality that may be obtained; and to assess the performance of alternative designs of burst systems that increase the neutron output and burst repetition rate. 21 refs., 8 figs., 5 tabs

  8. Large-scale biophysical evaluation of protein PEGylation effects

    DEFF Research Database (Denmark)

    Vernet, Erik; Popa, Gina; Pozdnyakova, Irina

    2016-01-01

    PEGylation is the most widely used method to chemically modify protein biopharmaceuticals, but surprisingly limited public data is available on the biophysical effects of protein PEGylation. Here we report the first large-scale study, with site-specific mono-PEGylation of 15 different proteins...... of PEGylation on the thermal stability of a protein based on data generated by circular dichroism (CD), differential scanning calorimetry (DSC), or differential scanning fluorimetry (DSF). In addition, DSF was validated as a fast and inexpensive screening method for thermal unfolding studies of PEGylated...... proteins. Multivariate data analysis revealed clear trends in biophysical properties upon PEGylation for a subset of proteins, although no universal trends were found. Taken together, these findings are important in the consideration of biophysical methods and evaluation of second...

  9. Optimization of large-scale fabrication of dielectric elastomer transducers

    DEFF Research Database (Denmark)

    Hassouneh, Suzan Sager

    Dielectric elastomers (DEs) have gained substantial ground in many different applications, such as wave energy harvesting, valves and loudspeakers. For DE technology to be commercially viable, it is necessary that any large-scale production operation is nondestructive, efficient and cheap. Danfoss......-strength laminates to perform as monolithic elements. For the front-to-back and front-to-front configurations, conductive elastomers were utilised. One approach involved adding the cheap and conductive filler, exfoliated graphite (EG) to a PDMS matrix to increase dielectric permittivity. The results showed that even...... as conductive adhesives were rejected. Dielectric properties below the percolation threshold were subsequently investigated, in order to conclude the study. In order to avoid destroying the network structure, carbon nanotubes (CNTs) were used as fillers during the preparation of the conductive elastomers...

  10. Large scale oil lease automation and electronic custody transfer

    International Nuclear Information System (INIS)

    Price, C.R.; Elmer, D.C.

    1995-01-01

    Typically, oil field production operations have only been automated at fields with long term production profiles and enhanced recovery. The automation generally consists of monitoring and control at the wellhead and centralized facilities. However, Union Pacific Resources Co. (UPRC) has successfully implemented a large scale automation program for rapid-decline primary recovery Austin Chalk wells where purchasers buy and transport oil from each individual wellsite. This project has resulted in two significant benefits. First, operators are using the system to re-engineer their work processes. Second, an inter-company team created a new electronic custody transfer method. This paper will describe: the progression of the company's automation objectives in the area; the field operator's interaction with the system, and the related benefits; the research and development of the new electronic custody transfer method

  11. USE OF RFID AT LARGE-SCALE EVENTS

    Directory of Open Access Journals (Sweden)

    Yuusuke KAWAKITA

    2005-01-01

    Full Text Available Radio Frequency Identification (RFID devices and related technologies have received a great deal of attention for their ability to perform non-contact object identification. Systems incorporating RFID have been evaluated from a variety of perspectives. The authors constructed a networked RFID system to support event management at NetWorld+Interop 2004 Tokyo, an event that received 150,000 visitors. The system used multiple RFID readers installed at the venue and RFID tags carried by each visitor to provide a platform for running various management and visitor support applications. This paper presents the results of this field trial of RFID readability rates. It further addresses the applicability of RFID systems to visitor management, a problematic aspect of large-scale events.

  12. Modeling of large-scale oxy-fuel combustion processes

    DEFF Research Database (Denmark)

    Yin, Chungen

    2012-01-01

    Quite some studies have been conducted in order to implement oxy-fuel combustion with flue gas recycle in conventional utility boilers as an effective effort of carbon capture and storage. However, combustion under oxy-fuel conditions is significantly different from conventional air-fuel firing......, among which radiative heat transfer under oxy-fuel conditions is one of the fundamental issues. This paper demonstrates the nongray-gas effects in modeling of large-scale oxy-fuel combustion processes. Oxy-fuel combustion of natural gas in a 609MW utility boiler is numerically studied, in which...... calculation of the oxy-fuel WSGGM remarkably over-predicts the radiative heat transfer to the furnace walls and under-predicts the gas temperature at the furnace exit plane, which also result in a higher incomplete combustion in the gray calculation. Moreover, the gray and non-gray calculations of the same...

  13. Large scale gas chromatographic demonstration system for hydrogen isotope separation

    International Nuclear Information System (INIS)

    Cheh, C.H.

    1988-01-01

    A large scale demonstration system was designed for a throughput of 3 mol/day equimolar mixture of H,D, and T. The demonstration system was assembled and an experimental program carried out. This project was funded by Kernforschungszentrum Karlsruhe, Canadian Fusion Fuel Technology Projects and Ontario Hydro Research Division. Several major design innovations were successfully implemented in the demonstration system and are discussed in detail. Many experiments were carried out in the demonstration system to study the performance of the system to separate hydrogen isotopes at high throughput. Various temperature programming schemes were tested, heart-cutting operation was evaluated, and very large (up to 138 NL/injection) samples were separated in the system. The results of the experiments showed that the specially designed column performed well as a chromatographic column and good separation could be achieved even when a 138 NL sample was injected

  14. Integral criteria for large-scale multiple fingerprint solutions

    Science.gov (United States)

    Ushmaev, Oleg S.; Novikov, Sergey O.

    2004-08-01

    We propose the definition and analysis of the optimal integral similarity score criterion for large scale multmodal civil ID systems. Firstly, the general properties of score distributions for genuine and impostor matches for different systems and input devices are investigated. The empirical statistics was taken from the real biometric tests. Then we carry out the analysis of simultaneous score distributions for a number of combined biometric tests and primary for ultiple fingerprint solutions. The explicit and approximate relations for optimal integral score, which provides the least value of the FRR while the FAR is predefined, have been obtained. The results of real multiple fingerprint test show good correspondence with the theoretical results in the wide range of the False Acceptance and the False Rejection Rates.

  15. Traffic assignment models in large-scale applications

    DEFF Research Database (Denmark)

    Rasmussen, Thomas Kjær

    the potential of the method proposed and the possibility to use individual-based GPS units for travel surveys in real-life large-scale multi-modal networks. Congestion is known to highly influence the way we act in the transportation network (and organise our lives), because of longer travel times...... of observations of actual behaviour to obtain estimates of the (monetary) value of different travel time components, thereby increasing the behavioural realism of largescale models. vii The generation of choice sets is a vital component in route choice models. This is, however, not a straight-forward task in real......, but the reliability of the travel time also has a large impact on our travel choices. Consequently, in order to improve the realism of transport models, correct understanding and representation of two values that are related to the value of time (VoT) are essential: (i) the value of congestion (VoC), as the Vo...

  16. Isolating relativistic effects in large-scale structure

    Science.gov (United States)

    Bonvin, Camille

    2014-12-01

    We present a fully relativistic calculation of the observed galaxy number counts in the linear regime. We show that besides the density fluctuations and redshift-space distortions, various relativistic effects contribute to observations at large scales. These effects all have the same physical origin: they result from the fact that our coordinate system, namely the galaxy redshift and the incoming photons’ direction, is distorted by inhomogeneities in our Universe. We then discuss the impact of the relativistic effects on the angular power spectrum and on the two-point correlation function in configuration space. We show that the latter is very well adapted to isolate the relativistic effects since it naturally makes use of the symmetries of the different contributions. In particular, we discuss how the Doppler effect and the gravitational redshift distortions can be isolated by looking for a dipole in the cross-correlation function between a bright and a faint population of galaxies.

  17. Risk Management Challenges in Large-scale Energy PSS

    DEFF Research Database (Denmark)

    Tegeltija, Miroslava; Oehmen, Josef; Kozin, Igor

    2017-01-01

    Probabilistic risk management approaches have a long tradition in engineering. A large variety of tools and techniques based on the probabilistic view of risk is available and applied in PSS practice. However, uncertainties that arise due to lack of knowledge and information are still missing...... adequate representations. We focus on a large-scale energy company in Denmark as one case of current product/servicesystems risk management best practices. We analyze their risk management process and investigate the tools they use in order to support decision making processes within the company. First, we...... identify the following challenges in the current risk management practices that are in line with literature: (1) current methods are not appropriate for the situations dominated by weak knowledge and information; (2) quality of traditional models in such situations is open to debate; (3) quality of input...

  18. Large Scale Simulation Platform for NODES Validation Study

    Energy Technology Data Exchange (ETDEWEB)

    Sotorrio, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Qin, Y. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Min, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-04-27

    This report summarizes the Large Scale (LS) simulation platform created for the Eaton NODES project. The simulation environment consists of both wholesale market simulator and distribution simulator and includes the CAISO wholesale market model and a PG&E footprint of 25-75 feeders to validate the scalability under a scenario of 33% RPS in California with additional 17% of DERS coming from distribution and customers. The simulator can generate hourly unit commitment, 5-minute economic dispatch, and 4-second AGC regulation signals. The simulator is also capable of simulating greater than 10k individual controllable devices. Simulated DERs include water heaters, EVs, residential and light commercial HVAC/buildings, and residential-level battery storage. Feeder-level voltage regulators and capacitor banks are also simulated for feeder-level real and reactive power management and Vol/Var control.

  19. Cosmological streaming velocities and large-scale density maxima

    International Nuclear Information System (INIS)

    Peacock, J.A.; Lumsden, S.L.; Heavens, A.F.

    1987-01-01

    The statistical testing of models for galaxy formation against the observed peculiar velocities on 10-100 Mpc scales is considered. If it is assumed that observers are likely to be sited near maxima in the primordial field of density perturbations, then the observed filtered velocity field will be biased to low values by comparison with a point selected at random. This helps to explain how the peculiar velocities (relative to the microwave background) of the local supercluster and the Rubin-Ford shell can be so similar in magnitude. Using this assumption to predict peculiar velocities on two scales, we test models with large-scale damping (i.e. adiabatic perturbations). Allowed models have a damping length close to the Rubin-Ford scale and are mildly non-linear. Both purely baryonic universes and universes dominated by massive neutrinos can account for the observed velocities, provided 0.1 ≤ Ω ≤ 1. (author)

  20. Engineering large-scale agent-based systems with consensus

    Science.gov (United States)

    Bokma, A.; Slade, A.; Kerridge, S.; Johnson, K.

    1994-01-01

    The paper presents the consensus method for the development of large-scale agent-based systems. Systems can be developed as networks of knowledge based agents (KBA) which engage in a collaborative problem solving effort. The method provides a comprehensive and integrated approach to the development of this type of system. This includes a systematic analysis of user requirements as well as a structured approach to generating a system design which exhibits the desired functionality. There is a direct correspondence between system requirements and design components. The benefits of this approach are that requirements are traceable into design components and code thus facilitating verification. The use of the consensus method with two major test applications showed it to be successful and also provided valuable insight into problems typically associated with the development of large systems.

  1. Future hydrogen markets for large-scale hydrogen production systems

    International Nuclear Information System (INIS)

    Forsberg, Charles W.

    2007-01-01

    The cost of delivered hydrogen includes production, storage, and distribution. For equal production costs, large users (>10 6 m 3 /day) will favor high-volume centralized hydrogen production technologies to avoid collection costs for hydrogen from widely distributed sources. Potential hydrogen markets were examined to identify and characterize those markets that will favor large-scale hydrogen production technologies. The two high-volume centralized hydrogen production technologies are nuclear energy and fossil energy with carbon dioxide sequestration. The potential markets for these technologies are: (1) production of liquid fuels (gasoline, diesel and jet) including liquid fuels with no net greenhouse gas emissions and (2) peak electricity production. The development of high-volume centralized hydrogen production technologies requires an understanding of the markets to (1) define hydrogen production requirements (purity, pressure, volumes, need for co-product oxygen, etc.); (2) define and develop technologies to use the hydrogen, and (3) create the industrial partnerships to commercialize such technologies. (author)

  2. Large Scale Emerging Properties from Non Hamiltonian Complex Systems

    Directory of Open Access Journals (Sweden)

    Marco Bianucci

    2017-06-01

    Full Text Available The concept of “large scale” depends obviously on the phenomenon we are interested in. For example, in the field of foundation of Thermodynamics from microscopic dynamics, the spatial and time large scales are order of fraction of millimetres and microseconds, respectively, or lesser, and are defined in relation to the spatial and time scales of the microscopic systems. In large scale oceanography or global climate dynamics problems the time scales of interest are order of thousands of kilometres, for space, and many years for time, and are compared to the local and daily/monthly times scales of atmosphere and ocean dynamics. In all the cases a Zwanzig projection approach is, at least in principle, an effective tool to obtain class of universal smooth “large scale” dynamics for few degrees of freedom of interest, starting from the complex dynamics of the whole (usually many degrees of freedom system. The projection approach leads to a very complex calculus with differential operators, that is drastically simplified when the basic dynamics of the system of interest is Hamiltonian, as it happens in Foundation of Thermodynamics problems. However, in geophysical Fluid Dynamics, Biology, and in most of the physical problems the building block fundamental equations of motions have a non Hamiltonian structure. Thus, to continue to apply the useful projection approach also in these cases, we exploit the generalization of the Hamiltonian formalism given by the Lie algebra of dissipative differential operators. In this way, we are able to analytically deal with the series of the differential operators stemming from the projection approach applied to these general cases. Then we shall apply this formalism to obtain some relevant results concerning the statistical properties of the El Niño Southern Oscillation (ENSO.

  3. Investigation of the large scale regional hydrogeological situation at Ceberg

    International Nuclear Information System (INIS)

    Boghammar, A.; Grundfelt, B.; Hartley, L.

    1997-11-01

    The present study forms part of the large-scale groundwater flow studies within the SR 97 project. The site of interest is Ceberg. Within the present study two different regional scale groundwater models have been constructed, one large regional model with an areal extent of about 300 km 2 and one semi-regional model with an areal extent of about 50 km 2 . Different types of boundary conditions have been applied to the models. Topography driven pressures, constant infiltration rates, non-linear infiltration combined specified pressure boundary conditions, and transfer of groundwater pressures from the larger model to the semi-regional model. The present model has shown that: -Groundwater flow paths are mainly local. Large-scale groundwater flow paths are only seen below the depth of the hypothetical repository (below 500 meters) and are very slow. -Locations of recharge and discharge, to and from the site area are in the close vicinity of the site. -The low contrast between major structures and the rock mass means that the factor having the major effect on the flowpaths is the topography. -A sufficiently large model, to incorporate the recharge and discharge areas to the local site is in the order of kilometres. -A uniform infiltration rate boundary condition does not give a good representation of the groundwater movements in the model. -A local site model may be located to cover the site area and a few kilometers of the surrounding region. In order to incorporate all recharge and discharge areas within the site model, the model will be somewhat larger than site scale models at other sites. This is caused by the fact that the discharge areas are divided into three distinct areas to the east, south and west of the site. -Boundary conditions may be supplied to the site model by means of transferring groundwater pressures obtained with the semi-regional model

  4. Hydrogen combustion modelling in large-scale geometries

    International Nuclear Information System (INIS)

    Studer, E.; Beccantini, A.; Kudriakov, S.; Velikorodny, A.

    2014-01-01

    Hydrogen risk mitigation issues based on catalytic recombiners cannot exclude flammable clouds to be formed during the course of a severe accident in a Nuclear Power Plant. Consequences of combustion processes have to be assessed based on existing knowledge and state of the art in CFD combustion modelling. The Fukushima accidents have also revealed the need for taking into account the hydrogen explosion phenomena in risk management. Thus combustion modelling in a large-scale geometry is one of the remaining severe accident safety issues. At present day there doesn't exist a combustion model which can accurately describe a combustion process inside a geometrical configuration typical of the Nuclear Power Plant (NPP) environment. Therefore the major attention in model development has to be paid on the adoption of existing approaches or creation of the new ones capable of reliably predicting the possibility of the flame acceleration in the geometries of that type. A set of experiments performed previously in RUT facility and Heiss Dampf Reactor (HDR) facility is used as a validation database for development of three-dimensional gas dynamic model for the simulation of hydrogen-air-steam combustion in large-scale geometries. The combustion regimes include slow deflagration, fast deflagration, and detonation. Modelling is based on Reactive Discrete Equation Method (RDEM) where flame is represented as an interface separating reactants and combustion products. The transport of the progress variable is governed by different flame surface wrinkling factors. The results of numerical simulation are presented together with the comparisons, critical discussions and conclusions. (authors)

  5. Iodine oxides in large-scale THAI tests

    International Nuclear Information System (INIS)

    Funke, F.; Langrock, G.; Kanzleiter, T.; Poss, G.; Fischer, K.; Kühnel, A.; Weber, G.; Allelein, H.-J.

    2012-01-01

    Highlights: ► Iodine oxide particles were produced from gaseous iodine and ozone. ► Ozone replaced the effect of ionizing radiation in the large-scale THAI facility. ► The mean diameter of the iodine oxide particles was about 0.35 μm. ► Particle formation was faster than the chemical reaction between iodine and ozone. ► Deposition of iodine oxide particles was slow in the absence of other aerosols. - Abstract: The conversion of gaseous molecular iodine into iodine oxide aerosols has significant relevance in the understanding of the fission product iodine volatility in a LWR containment during severe accidents. In containment, the high radiation field caused by fission products released from the reactor core induces radiolytic oxidation into iodine oxides. To study the characteristics and the behaviour of iodine oxides in large scale, two THAI tests Iod-13 and Iod-14 were performed, simulating radiolytic oxidation of molecular iodine by reaction of iodine with ozone, with ozone injected from an ozone generator. The observed iodine oxides form submicron particles with mean volume-related diameters of about 0.35 μm and show low deposition rates in the THAI tests performed in the absence of other nuclear aerosols. Formation of iodine aerosols from gaseous precursors iodine and ozone is fast as compared to their chemical interaction. The current approach in empirical iodine containment behaviour models in severe accidents, including the radiolytic production of I 2 -oxidizing agents followed by the I 2 oxidation itself, is confirmed by these THAI tests.

  6. Large-Scale Structure Behind The Milky Way with ALFAZOA

    Science.gov (United States)

    Sanchez Barrantes, Monica; Henning, Patricia A.; Momjian, Emmanuel; McIntyre, Travis; Minchin, Robert F.

    2018-06-01

    The region of the sky behind the Milky Way (the Zone of Avoidance; ZOA) is not well studied due to high obscuration from gas and dust in our galaxy as well as stellar confusion, which results in low detection rate of galaxies in this region. Because of this, little is known about the distribution of galaxies in the ZOA, and other all sky redshift surveys have incomplete maps (e.g. the 2MASS Redshift survey in NIR has a gap of 5-8 deg around the Galactic plane). There is still controversy about the dipole anisotropy calculated from the comparison between the CMB and galaxy and redshift surveys, in part due to the incomplete sky mapping and redshift depth of these surveys. Fortunately, there is no ZOA at radio wavelengths because such wavelengths can pass unimpeded through dust and are not affected by stellar confusion. Therefore, we can detect and make a map of the distribution of obscured galaxies that contain the 21cm neutral hydrogen emission line, and trace the large-scale structure across the Galactic plane. The Arecibo L-Band Feed Array Zone of Avoidance (ALFAZOA) survey is a blind HI survey for galaxies behind the Milky Way that covers more than 1000 square degrees of the sky, conducted in two phases: shallow (completed) and deep (ongoing). We show the results of the finished shallow phase of the survey, which mapped a region between the galactic longitude l=30-75 deg, and latitude b <|10 deg|, and detected 418 galaxies to about 12,000 km/s, including galaxy properties and mapped large-scale structure. We do the same for new results from the deep phase, which is ongoing and covers 30 < l < 75 deg and b < |2| deg for the inner galaxy and 175 < l < 207 deg, with -2 < b < 1 for the outer galaxy.

  7. In situ vitrification large-scale operational acceptance test analysis

    International Nuclear Information System (INIS)

    Buelt, J.L.; Carter, J.G.

    1986-05-01

    A thermal treatment process is currently under study to provide possible enhancement of in-place stabilization of transuranic and chemically contaminated soil sites. The process is known as in situ vitrification (ISV). In situ vitrification is a remedial action process that destroys solid and liquid organic contaminants and incorporates radionuclides into a glass-like material that renders contaminants substantially less mobile and less likely to impact the environment. A large-scale operational acceptance test (LSOAT) was recently completed in which more than 180 t of vitrified soil were produced in each of three adjacent settings. The LSOAT demonstrated that the process conforms to the functional design criteria necessary for the large-scale radioactive test (LSRT) to be conducted following verification of the performance capabilities of the process. The energy requirements and vitrified block size, shape, and mass are sufficiently equivalent to those predicted by the ISV mathematical model to confirm its usefulness as a predictive tool. The LSOAT demonstrated an electrode replacement technique, which can be used if an electrode fails, and techniques have been identified to minimize air oxidation, thereby extending electrode life. A statistical analysis was employed during the LSOAT to identify graphite collars and an insulative surface as successful cold cap subsidence techniques. The LSOAT also showed that even under worst-case conditions, the off-gas system exceeds the flow requirements necessary to maintain a negative pressure on the hood covering the area being vitrified. The retention of simulated radionuclides and chemicals in the soil and off-gas system exceeds requirements so that projected emissions are one to two orders of magnitude below the maximum permissible concentrations of contaminants at the stack

  8. Disinformative data in large-scale hydrological modelling

    Directory of Open Access Journals (Sweden)

    A. Kauffeldt

    2013-07-01

    Full Text Available Large-scale hydrological modelling has become an important tool for the study of global and regional water resources, climate impacts, and water-resources management. However, modelling efforts over large spatial domains are fraught with problems of data scarcity, uncertainties and inconsistencies between model forcing and evaluation data. Model-independent methods to screen and analyse data for such problems are needed. This study aimed at identifying data inconsistencies in global datasets using a pre-modelling analysis, inconsistencies that can be disinformative for subsequent modelling. The consistency between (i basin areas for different hydrographic datasets, and (ii between climate data (precipitation and potential evaporation and discharge data, was examined in terms of how well basin areas were represented in the flow networks and the possibility of water-balance closure. It was found that (i most basins could be well represented in both gridded basin delineations and polygon-based ones, but some basins exhibited large area discrepancies between flow-network datasets and archived basin areas, (ii basins exhibiting too-high runoff coefficients were abundant in areas where precipitation data were likely affected by snow undercatch, and (iii the occurrence of basins exhibiting losses exceeding the potential-evaporation limit was strongly dependent on the potential-evaporation data, both in terms of numbers and geographical distribution. Some inconsistencies may be resolved by considering sub-grid variability in climate data, surface-dependent potential-evaporation estimates, etc., but further studies are needed to determine the reasons for the inconsistencies found. Our results emphasise the need for pre-modelling data analysis to identify dataset inconsistencies as an important first step in any large-scale study. Applying data-screening methods before modelling should also increase our chances to draw robust conclusions from subsequent

  9. On soft limits of large-scale structure correlation functions

    International Nuclear Information System (INIS)

    Sagunski, Laura

    2016-08-01

    Large-scale structure surveys have the potential to become the leading probe for precision cosmology in the next decade. To extract valuable information on the cosmological evolution of the Universe from the observational data, it is of major importance to derive accurate theoretical predictions for the statistical large-scale structure observables, such as the power spectrum and the bispectrum of (dark) matter density perturbations. Hence, one of the greatest challenges of modern cosmology is to theoretically understand the non-linear dynamics of large-scale structure formation in the Universe from first principles. While analytic approaches to describe the large-scale structure formation are usually based on the framework of non-relativistic cosmological perturbation theory, we pursue another road in this thesis and develop methods to derive generic, non-perturbative statements about large-scale structure correlation functions. We study unequal- and equal-time correlation functions of density and velocity perturbations in the limit where one of their wavenumbers becomes small, that is, in the soft limit. In the soft limit, it is possible to link (N+1)-point and N-point correlation functions to non-perturbative 'consistency conditions'. These provide in turn a powerful tool to test fundamental aspects of the underlying theory at hand. In this work, we first rederive the (resummed) consistency conditions at unequal times by using the so-called eikonal approximation. The main appeal of the unequal-time consistency conditions is that they are solely based on symmetry arguments and thus are universal. Proceeding from this, we direct our attention to consistency conditions at equal times, which, on the other hand, depend on the interplay between soft and hard modes. We explore the existence and validity of equal-time consistency conditions within and beyond perturbation theory. For this purpose, we investigate the predictions for the soft limit of the

  10. On soft limits of large-scale structure correlation functions

    Energy Technology Data Exchange (ETDEWEB)

    Sagunski, Laura

    2016-08-15

    Large-scale structure surveys have the potential to become the leading probe for precision cosmology in the next decade. To extract valuable information on the cosmological evolution of the Universe from the observational data, it is of major importance to derive accurate theoretical predictions for the statistical large-scale structure observables, such as the power spectrum and the bispectrum of (dark) matter density perturbations. Hence, one of the greatest challenges of modern cosmology is to theoretically understand the non-linear dynamics of large-scale structure formation in the Universe from first principles. While analytic approaches to describe the large-scale structure formation are usually based on the framework of non-relativistic cosmological perturbation theory, we pursue another road in this thesis and develop methods to derive generic, non-perturbative statements about large-scale structure correlation functions. We study unequal- and equal-time correlation functions of density and velocity perturbations in the limit where one of their wavenumbers becomes small, that is, in the soft limit. In the soft limit, it is possible to link (N+1)-point and N-point correlation functions to non-perturbative 'consistency conditions'. These provide in turn a powerful tool to test fundamental aspects of the underlying theory at hand. In this work, we first rederive the (resummed) consistency conditions at unequal times by using the so-called eikonal approximation. The main appeal of the unequal-time consistency conditions is that they are solely based on symmetry arguments and thus are universal. Proceeding from this, we direct our attention to consistency conditions at equal times, which, on the other hand, depend on the interplay between soft and hard modes. We explore the existence and validity of equal-time consistency conditions within and beyond perturbation theory. For this purpose, we investigate the predictions for the soft limit of the

  11. Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

    Directory of Open Access Journals (Sweden)

    Els Torreele

    2010-12-01

    , 30% in rats, and 10% in dogs. Furthermore, fexinidazole is rapidly metabolised in vivo to at least two biologically active metabolites (a sulfoxide and a sulfone derivative that likely account for a significant portion of the therapeutic effect. Key pharmacokinetic parameter after oral absorption in mice for fexinidazole and its sulfoxide and sulfone metabolites are a C(max of 500, 14171 and 13651 ng/mL respectively, and an AUC₀₋₂₄ of 424, 45031 and 96286 h.ng/mL respectively. Essentially similar PK profiles were observed in rats and dogs. Toxicology studies (including safety pharmacology and 4-weeks repeated-dose toxicokinetics in rat and dog have shown that fexinidazole is well tolerated. The No Observed Adverse Event Levels in the 4-weeks repeated dose toxicity studies in rats and dogs was 200 mg/kg/day in both species, with no issues of concern identified for doses up to 800 mg/kg/day. While fexinidazole, like many nitroheterocycles, is mutagenic in the Ames test due to bacterial specific metabolism, it is not genotoxic to mammalian cells in vitro or in vivo as assessed in an in vitro micronucleus test on human lymphocytes, an in vivo mouse bone marrow micronucleus test, and an ex vivo unscheduled DNA synthesis test in rats.The results of the preclinical pharmacological and safety studies indicate that fexinidazole is a safe and effective oral drug candidate with no untoward effects that would preclude evaluation in man. The drug has entered first-in-human phase I studies in September 2009. Fexinidazole is the first new clinical drug candidate with the potential for treating advanced-stage sleeping sickness in thirty years.

  12. A large-scale peer teaching programme - acceptance and benefit.

    Science.gov (United States)

    Schuetz, Elisabeth; Obirei, Barbara; Salat, Daniela; Scholz, Julia; Hann, Dagmar; Dethleffsen, Kathrin

    2017-08-01

    The involvement of students in the embodiment of university teaching through peer-assisted learning formats is commonly applied. Publications on this topic exclusively focus on strictly defined situations within the curriculum and selected target groups. This study, in contrast, presents and evaluates a large-scale structured and quality-assured peer teaching programme, which offers diverse and targeted courses throughout the preclinical part of the medical curriculum. The large-scale peer teaching programme consists of subject specific and interdisciplinary tutorials that address all scientific, physiological and anatomic subjects of the preclinical curriculum as well as tutorials with contents exceeding the formal curriculum. In the study year 2013/14 a total of 1,420 lessons were offered as part of the programme. Paper-based evaluations were conducted over the full range of courses. Acceptance and benefit of this peer teaching programme were evaluated in a retrospective study covering the period 2012 to 2014. Usage of tutorials by students who commenced their studies in 2012/13 (n=959) was analysed from 2012 till 2014. Based on the results of 13 first assessments in the preclinical subjects anatomy, biochemistry and physiology, the students were assigned to one of five groups. These groups were compared according to participation in the tutorials. To investigate the benefit of tutorials of the peer teaching programme, the results of biochemistry re-assessments of participants and non-participants of tutorials in the years 2012 till 2014 (n=188, 172 and 204, respectively) were compared using Kolmogorov-Smirnov- and Chi-square tests as well as the effect size Cohen's d. Almost 70 % of the students attended the voluntary additional programme during their preclinical studies. The students participating in the tutorials had achieved different levels of proficiency in first assessments. The acceptance of different kinds of tutorials appears to correlate with their

  13. Updating Geospatial Data from Large Scale Data Sources

    Science.gov (United States)

    Zhao, R.; Chen, J.; Wang, D.; Shang, Y.; Wang, Z.; Li, X.; Ai, T.

    2011-08-01

    In the past decades, many geospatial databases have been established at national, regional and municipal levels over the world. Nowadays, it has been widely recognized that how to update these established geo-spatial database and keep them up to date is most critical for the value of geo-spatial database. So, more and more efforts have been devoted to the continuous updating of these geospatial databases. Currently, there exist two main types of methods for Geo-spatial database updating: directly updating with remote sensing images or field surveying materials, and indirectly updating with other updated data result such as larger scale newly updated data. The former method is the basis because the update data sources in the two methods finally root from field surveying and remote sensing. The later method is often more economical and faster than the former. Therefore, after the larger scale database is updated, the smaller scale database should be updated correspondingly in order to keep the consistency of multi-scale geo-spatial database. In this situation, it is very reasonable to apply map generalization technology into the process of geo-spatial database updating. The latter is recognized as one of most promising methods of geo-spatial database updating, especially in collaborative updating environment in terms of map scale, i.e , different scale database are produced and maintained separately by different level organizations such as in China. This paper is focused on applying digital map generalization into the updating of geo-spatial database from large scale in the collaborative updating environment for SDI. The requirements of the application of map generalization into spatial database updating are analyzed firstly. A brief review on geospatial data updating based digital map generalization is then given. Based on the requirements analysis and review, we analyze the key factors for implementing updating geospatial data from large scale including technical

  14. Reconstructing Information in Large-Scale Structure via Logarithmic Mapping

    Science.gov (United States)

    Szapudi, Istvan

    We propose to develop a new method to extract information from large-scale structure data combining two-point statistics and non-linear transformations; before, this information was available only with substantially more complex higher-order statistical methods. Initially, most of the cosmological information in large-scale structure lies in two-point statistics. With non- linear evolution, some of that useful information leaks into higher-order statistics. The PI and group has shown in a series of theoretical investigations how that leakage occurs, and explained the Fisher information plateau at smaller scales. This plateau means that even as more modes are added to the measurement of the power spectrum, the total cumulative information (loosely speaking the inverse errorbar) is not increasing. Recently we have shown in Neyrinck et al. (2009, 2010) that a logarithmic (and a related Gaussianization or Box-Cox) transformation on the non-linear Dark Matter or galaxy field reconstructs a surprisingly large fraction of this missing Fisher information of the initial conditions. This was predicted by the earlier wave mechanical formulation of gravitational dynamics by Szapudi & Kaiser (2003). The present proposal is focused on working out the theoretical underpinning of the method to a point that it can be used in practice to analyze data. In particular, one needs to deal with the usual real-life issues of galaxy surveys, such as complex geometry, discrete sam- pling (Poisson or sub-Poisson noise), bias (linear, or non-linear, deterministic, or stochastic), redshift distortions, pro jection effects for 2D samples, and the effects of photometric redshift errors. We will develop methods for weak lensing and Sunyaev-Zeldovich power spectra as well, the latter specifically targetting Planck. In addition, we plan to investigate the question of residual higher- order information after the non-linear mapping, and possible applications for cosmology. Our aim will be to work out

  15. Alignment between galaxies and large-scale structure

    International Nuclear Information System (INIS)

    Faltenbacher, A.; Li Cheng; White, Simon D. M.; Jing, Yi-Peng; Mao Shude; Wang Jie

    2009-01-01

    Based on the Sloan Digital Sky Survey DR6 (SDSS) and the Millennium Simulation (MS), we investigate the alignment between galaxies and large-scale structure. For this purpose, we develop two new statistical tools, namely the alignment correlation function and the cos(2θ)-statistic. The former is a two-dimensional extension of the traditional two-point correlation function and the latter is related to the ellipticity correlation function used for cosmic shear measurements. Both are based on the cross correlation between a sample of galaxies with orientations and a reference sample which represents the large-scale structure. We apply the new statistics to the SDSS galaxy catalog. The alignment correlation function reveals an overabundance of reference galaxies along the major axes of red, luminous (L ∼ * ) galaxies out to projected separations of 60 h- 1 Mpc. The signal increases with central galaxy luminosity. No alignment signal is detected for blue galaxies. The cos(2θ)-statistic yields very similar results. Starting from a MS semi-analytic galaxy catalog, we assign an orientation to each red, luminous and central galaxy, based on that of the central region of the host halo (with size similar to that of the stellar galaxy). As an alternative, we use the orientation of the host halo itself. We find a mean projected misalignment between a halo and its central region of ∼ 25 deg. The misalignment decreases slightly with increasing luminosity of the central galaxy. Using the orientations and luminosities of the semi-analytic galaxies, we repeat our alignment analysis on mock surveys of the MS. Agreement with the SDSS results is good if the central orientations are used. Predictions using the halo orientations as proxies for central galaxy orientations overestimate the observed alignment by more than a factor of 2. Finally, the large volume of the MS allows us to generate a two-dimensional map of the alignment correlation function, which shows the reference

  16. Food security through large scale investments in agriculture

    Science.gov (United States)

    Rulli, M.; D'Odorico, P.

    2013-12-01

    Most of the human appropriation of freshwater resources is for food production. There is some concern that in the near future the finite freshwater resources available on Earth might not be sufficient to meet the increasing human demand for agricultural products. In the late 1700s Malthus argued that in the long run the humanity would not have enough resources to feed itself. Malthus' analysis, however, did not account for the emergence of technological innovations that could increase the rate of food production. The modern and contemporary history has seen at least three major technological advances that have increased humans' access to food, namely, the industrial revolution, the green revolution, and the intensification of global trade. Here we argue that a fourth revolution has just started to happen. It involves foreign direct investments in agriculture, which intensify the crop yields of potentially highly productive agricultural lands by introducing the use of more modern technologies. The increasing demand for agricultural products and the uncertainty of international food markets has recently drawn the attention of governments and agribusiness firms toward investments in productive agricultural land, mostly in the developing world. The targeted countries are typically located in regions that have remained only marginally utilized because of lack of modern technology. It is expected that in the long run large scale land acquisitions for commercial farming will bring the technology required to close the existing yield gaps. While the extent of the acquired land and the associated appropriation of freshwater resources have been investigated in detail, the amount of food this land can produce and the number of people it could feed still need to be quantified. Here we use a unique dataset of verified land deals to provide a global quantitative assessment of the rates of crop and food appropriation potentially associated with large scale land acquisitions. We

  17. Large-Scale Spray Releases: Additional Aerosol Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, Richard C.; Gauglitz, Phillip A.; Burns, Carolyn A.; Fountain, Matthew S.; Shimskey, Rick W.; Billing, Justin M.; Bontha, Jagannadha R.; Kurath, Dean E.; Jenks, Jeromy WJ; MacFarlan, Paul J.; Mahoney, Lenna A.

    2013-08-01

    One of the events postulated in the hazard analysis for the Waste Treatment and Immobilization Plant (WTP) and other U.S. Department of Energy (DOE) nuclear facilities is a breach in process piping that produces aerosols with droplet sizes in the respirable range. The current approach for predicting the size and concentration of aerosols produced in a spray leak event involves extrapolating from correlations reported in the literature. These correlations are based on results obtained from small engineered spray nozzles using pure liquids that behave as a Newtonian fluid. The narrow ranges of physical properties on which the correlations are based do not cover the wide range of slurries and viscous materials that will be processed in the WTP and in processing facilities across the DOE complex. To expand the data set upon which the WTP accident and safety analyses were based, an aerosol spray leak testing program was conducted by Pacific Northwest National Laboratory (PNNL). PNNL’s test program addressed two key technical areas to improve the WTP methodology (Larson and Allen 2010). The first technical area was to quantify the role of slurry particles in small breaches where slurry particles may plug the hole and prevent high-pressure sprays. The results from an effort to address this first technical area can be found in Mahoney et al. (2012a). The second technical area was to determine aerosol droplet size distribution and total droplet volume from prototypic breaches and fluids, including sprays from larger breaches and sprays of slurries for which literature data are mostly absent. To address the second technical area, the testing program collected aerosol generation data at two scales, commonly referred to as small-scale and large-scale testing. The small-scale testing and resultant data are described in Mahoney et al. (2012b), and the large-scale testing and resultant data are presented in Schonewill et al. (2012). In tests at both scales, simulants were used

  18. Large scale solar district heating. Evaluation, modelling and designing

    Energy Technology Data Exchange (ETDEWEB)

    Heller, A.

    2000-07-01

    The main objective of the research was to evaluate large-scale solar heating connected to district heating (CSDHP), to build up a simulation tool and to demonstrate the application of the tool for design studies and on a local energy planning case. The evaluation of the central solar heating technology is based on measurements on the case plant in Marstal, Denmark, and on published and unpublished data for other, mainly Danish, CSDHP plants. Evaluations on the thermal, economical and environmental performances are reported, based on the experiences from the last decade. The measurements from the Marstal case are analysed, experiences extracted and minor improvements to the plant design proposed. For the detailed designing and energy planning of CSDHPs, a computer simulation model is developed and validated on the measurements from the Marstal case. The final model is then generalised to a 'generic' model for CSDHPs in general. The meteorological reference data, Danish Reference Year, is applied to find the mean performance for the plant designs. To find the expectable variety of the thermal performance of such plants, a method is proposed where data from a year with poor solar irradiation and a year with strong solar irradiation are applied. Equipped with a simulation tool design studies are carried out spreading from parameter analysis over energy planning for a new settlement to a proposal for the combination of plane solar collectors with high performance solar collectors, exemplified by a trough solar collector. The methodology of utilising computer simulation proved to be a cheap and relevant tool in the design of future solar heating plants. The thesis also exposed the demand for developing computer models for the more advanced solar collector designs and especially for the control operation of CSHPs. In the final chapter the CSHP technology is put into perspective with respect to other possible technologies to find the relevance of the application

  19. Coupled radiative gasdynamic interaction and non-equilibrium dissociation for large-scale returned space vehicles

    International Nuclear Information System (INIS)

    Surzhikov, S.

    2012-01-01

    Graphical abstract: It has been shown that different coupled vibrational dissociation models, being applied for solving coupled radiative gasdynamic problems for large size space vehicles, exert noticeable effect on radiative heating of its surface at orbital entry on high altitudes (h ⩾ 70 km). This influence decreases with decreasing the space vehicles sizes. Figure shows translational (solid lines) and vibrational (dashed lines) temperatures in shock layer with (circle markers) and without (triangles markers) radiative-gasdynamic interaction for one trajectory point of entering space vehicle. Highlights: ► Nonequilibrium dissociation processes exert effect on radiation heating of space vehicles (SV). ► The radiation gas dynamic interaction enhances this influence. ► This influence increases with increasing the SV sizes. - Abstract: Radiative aerothermodynamics of large-scale space vehicles is considered for Earth orbital entry at zero angle of attack. Brief description of used radiative gasdynamic model of physically and chemically nonequilibrium, viscous, heat conductive and radiative gas of complex chemical composition is presented. Radiation gasdynamic (RadGD) interaction in high temperature shock layer is studied by means of numerical experiment. It is shown that radiation–gasdynamic coupling for orbital space vehicles of large size is important for high altitude part of entering trajectory. It is demonstrated that the use of different models of coupled vibrational dissociation (CVD) in conditions of RadGD interaction gives rise temperature variation in shock layer and, as a result, leads to significant variation of radiative heating of space vehicle.

  20. LEMON - LHC Era Monitoring for Large-Scale Infrastructures

    International Nuclear Information System (INIS)

    Babik, Marian; Hook, Nicholas; Lansdale, Thomas Hector; Lenkes, Daniel; Siket, Miroslav; Waldron, Denis; Fedorko, Ivan

    2011-01-01

    At the present time computer centres are facing a massive rise in virtualization and cloud computing as these solutions bring advantages to service providers and consolidate the computer centre resources. However, as a result the monitoring complexity is increasing. Computer centre management requires not only to monitor servers, network equipment and associated software but also to collect additional environment and facilities data (e.g. temperature, power consumption, cooling efficiency, etc.) to have also a good overview of the infrastructure performance. The LHC Era Monitoring (Lemon) system is addressing these requirements for a very large scale infrastructure. The Lemon agent that collects data on every client and forwards the samples to the central measurement repository provides a flexible interface that allows rapid development of new sensors. The system allows also to report on behalf of remote devices such as switches and power supplies. Online and historical data can be visualized via a web-based interface or retrieved via command-line tools. The Lemon Alarm System component can be used for notifying the operator about error situations. In this article, an overview of the Lemon monitoring is provided together with a description of the CERN LEMON production instance. No direct comparison is made with other monitoring tool.