Space Processing Applications rocket project SPAR III. Final report

International Nuclear Information System (INIS)

Reeves, F.

1978-01-01

This document presents the engineering report and science payload III test report and summarizes the experiment objectives, design/operational concepts, and final results of each of five scientific experiments conducted during the third Space Processing Applications Rocket (SPAR) flight flown by NASA in December 1976. The five individual SPAR experiments, covering a wide and varied range of scientific materials processing objectives, were entitled: Liquid Mixing, Interaction of Bubbles with Solidification Interfaces, Epitaxial Growth of Single Crystal Film, Containerless Processing of Beryllium, and Contact and Coalescence of Viscous Bodies

The development and application of CFD technology in mechanical engineering

Science.gov (United States)

Wei, Yufeng

2017-12-01

Computational Fluid Dynamics (CFD) is an analysis of the physical phenomena involved in fluid flow and heat conduction by computer numerical calculation and graphical display. The numerical method simulates the complexity of the physical problem and the precision of the numerical solution, which is directly related to the hardware speed of the computer and the hardware such as memory. With the continuous improvement of computer performance and CFD technology, it has been widely applied to the field of water conservancy engineering, environmental engineering and industrial engineering. This paper summarizes the development process of CFD, the theoretical basis, the governing equations of fluid mechanics, and introduces the various methods of numerical calculation and the related development of CFD technology. Finally, CFD technology in the mechanical engineering related applications are summarized. It is hoped that this review will help researchers in the field of mechanical engineering.

New off-road engines for TIER 4 final; Neue Offroad-Motoren fuer Tier 4 final

Energy Technology Data Exchange (ETDEWEB)

Adt, Hans-Ulrich; Lehmann, Henrik [MTU Friedrichshafen GmbH, Friedrichshafen (Germany); Herter, Yvonne; Weidler, Alexander [Daimler AG, Stuttgart (Germany). Baureihe 1000

2013-03-15

To meet the off-road emission standards EU IV and EPA Tier 4 final, as of 2014 the Tognum Group will be offering newly developed engines of the Series 1000 to 1500. These MTU brand diesel engines deliver outputs ranging from 100 to 460 kW and are designed to power agricultural and forestry machinery and construction as well as special-purpose machinery. (orig.)

Engineering Adaptive Applications

DEFF Research Database (Denmark)

Dolog, Peter

for a domain.In this book, we propose a new domain engineering framework which extends a development process of Web applications with techniques required when designing such adaptive customizable Web applications. The framework is provided with design abstractions which deal separately with information served...

What Do Final Year Engineering Students Know about Sustainable Development?

Science.gov (United States)

Nicolaou, I.; Conlon, E.

2012-01-01

This paper presents data from a project that aims to determine the level of knowledge and understanding of engineering students about sustainable development (SD). The data derive from a survey completed by final year engineering students in three Irish Higher Education Institutions. This paper is part of a larger study that examines the…

Master on Nuclear Engineering and Applications (MINA): instrument of knowledge management in the nuclear sector

International Nuclear Information System (INIS)

Herranz, L. E.; Garcia Cuesta, J. C.; Falcon, S.; Casas, J. A.

2013-01-01

Knowledge Management in nuclear industry is indespensable to ensure excellence in performance and safety of nuclear installations. The Master on Nuclear Engineering and Applications (MINA) is a Spanish education venture which foundations and evolution have meant and adaptation to the European Education system and to the domestic and international changes occured in the nuclear environment. This paper summarizes the most relevant aspects of such transformation, its motivation and the final outcome. Finally, it discusses the potential benefit of a closer collaboration among the existing national education ventures in the frame of Nuclear Engineering. (Author)

Catastrophe theory and its application status in mechanical engineering

Directory of Open Access Journals (Sweden)

Jinge LIU

Full Text Available Catastrophe theory is a kind of mathematical method which aims to apply and interpret the discontinuous phenomenon. Since its emergence, it has been widely used to explain a variety of emergent phenomena in the fields of natural science, social science, management science and some other science and technology fields. Firstly, this paper introduces the theory of catastrophe in several aspects, such as its generation, radical principle, basic characteristics and development. Secondly, it summarizes the main applications of catastrophe theory in the field of mechanical engineering, focusing on the research progress of catastrophe theory in revealing catastrophe of rotor vibration state, analyzing friction and wear failure, predicting metal fracture, and so on. Finally, it advises that later development of catastrophe theory should pay more attention to the combination of itself with other traditional nonlinear theories and methods. This paper provides a beneficial reference to guide the application of catastrophe theory in mechanical engineering and related fields for later research.

Advances in Computer Science, Engineering & Applications : Proceedings of the Second International Conference on Computer Science, Engineering & Applications

CERN Document Server

Zizka, Jan; Nagamalai, Dhinaharan

2012-01-01

The International conference series on Computer Science, Engineering & Applications (ICCSEA) aims to bring together researchers and practitioners from academia and industry to focus on understanding computer science, engineering and applications and to establish new collaborations in these areas. The Second International Conference on Computer Science, Engineering & Applications (ICCSEA-2012), held in Delhi, India, during May 25-27, 2012 attracted many local and international delegates, presenting a balanced mixture of  intellect and research both from the East and from the West. Upon a strenuous peer-review process the best submissions were selected leading to an exciting, rich and a high quality technical conference program, which featured high-impact presentations in the latest developments of various areas of computer science, engineering and applications research.

Advances in Computer Science, Engineering & Applications : Proceedings of the Second International Conference on Computer Science, Engineering & Applications

CERN Document Server

Zizka, Jan; Nagamalai, Dhinaharan

2012-01-01

The International conference series on Computer Science, Engineering & Applications (ICCSEA) aims to bring together researchers and practitioners from academia and industry to focus on understanding computer science, engineering and applications and to establish new collaborations in these areas. The Second International Conference on Computer Science, Engineering & Applications (ICCSEA-2012), held in Delhi, India, during May 25-27, 2012 attracted many local and international delegates, presenting a balanced mixture of  intellect and research both from the East and from the West. Upon a strenuous peer-review process the best submissions were selected leading to an exciting, rich and a high quality technical conference program, which featured high-impact presentations in the latest developments of various areas of computer science, engineering and applications research.  

Recent applications of synthetic biology tools for yeast metabolic engineering

DEFF Research Database (Denmark)

Jensen, Michael Krogh; Keasling, Jay

2015-01-01

to engineer microbial chemical factories has steadily decreased, improvement is still needed. Through the development of synthetic biology tools for key microbial hosts, it should be possible to further decrease the development times and improve the reliability of the resulting microorganism. Together...... with continuous decreases in price and improvements in DNA synthesis, assembly and sequencing, synthetic biology tools will rationalize time-consuming strain engineering, improve control of metabolic fluxes, and diversify screening assays for cellular metabolism. This review outlines some recently developed...... synthetic biology tools and their application to improve production of chemicals and fuels in yeast. Finally, we provide a perspective for the challenges that lie ahead....

Engineering applications of soft computing

CERN Document Server

Díaz-Cortés, Margarita-Arimatea; Rojas, Raúl

2017-01-01

This book bridges the gap between Soft Computing techniques and their applications to complex engineering problems. In each chapter we endeavor to explain the basic ideas behind the proposed applications in an accessible format for readers who may not possess a background in some of the fields. Therefore, engineers or practitioners who are not familiar with Soft Computing methods will appreciate that the techniques discussed go beyond simple theoretical tools, since they have been adapted to solve significant problems that commonly arise in such areas. At the same time, the book will show members of the Soft Computing community how engineering problems are now being solved and handled with the help of intelligent approaches. Highlighting new applications and implementations of Soft Computing approaches in various engineering contexts, the book is divided into 12 chapters. Further, it has been structured so that each chapter can be read independently of the others.

Nonlinear Approaches in Engineering Applications

CERN Document Server

Jazar, Reza

2012-01-01

Nonlinear Approaches in Engineering Applications focuses on nonlinear phenomena that are common in the engineering field. The nonlinear approaches described in this book provide a sound theoretical base and practical tools to design and analyze engineering systems with high efficiency and accuracy and with less energy and downtime. Presented here are nonlinear approaches in areas such as dynamic systems, optimal control and approaches in nonlinear dynamics and acoustics. Coverage encompasses a wide range of applications and fields including mathematical modeling and nonlinear behavior as applied to microresonators, nanotechnologies, nonlinear behavior in soil erosion,nonlinear population dynamics, and optimization in reducing vibration and noise as well as vibration in triple-walled carbon nanotubes. This book also: Provides a complete introduction to nonlinear behavior of systems and the advantages of nonlinearity as a tool for solving engineering problems Includes applications and examples drawn from the el...

Final report : evaluation of microcomputer applications in transportation engineering.

Science.gov (United States)

1984-01-01

This study investigated areas where microcomputers can aid in the effectiveness of transportation engineering at state and local levels. A survey of the microcomputer needs of transportation professionals in state and local agencies in Virginia was c...

In situ and ex situ modifications of bacterial cellulose for applications in tissue engineering.

Science.gov (United States)

Stumpf, Taisa Regina; Yang, Xiuying; Zhang, Jingchang; Cao, Xudong

2018-01-01

Bacterial cellulose (BC) is secreted by a few strains of bacteria and consists of a cellulose nanofiber network with unique characteristics. Because of its excellent mechanical properties, outstanding biocompatibilities, and abilities to form porous structures, BC has been studied for a variety of applications in different fields, including the use as a biomaterial for scaffolds in tissue engineering. To extend its applications in tissue engineering, native BC is normally modified to enhance its properties. Generally, BC modifications can be made by either in situ modification during cell culture or ex situ modification of existing BC microfibers. In this review we will first provide a brief introduction of BC and its attributes; this will set the stage for in-depth and up-to-date discussions on modified BC. Finally, the review will focus on in situ and ex situ modifications of BC and its applications in tissue engineering, particularly in bone regeneration and wound dressing. Copyright © 2016. Published by Elsevier B.V.

Nonlinear approaches in engineering applications 2

CERN Document Server

Jazar, Reza N

2013-01-01

Provides updated principles and applications of the nonlinear approaches in solving engineering and physics problems Demonstrates how nonlinear approaches may open avenues to better, safer, cheaper systems with less energy consumption Has a strong emphasis on the application, physical meaning, and methodologies of nonlinear approaches in different engineering and science problems

Microwave power engineering applications

CERN Document Server

Okress, Ernest C

2013-01-01

Microwave Power Engineering, Volume 2: Applications introduces the electronics technology of microwave power and its applications. This technology emphasizes microwave electronics for direct power utilization and transmission purposes. This volume presents the accomplishments with respect to components, systems, and applications and their prevailing limitations in the light of knowledge of the microwave power technology. The applications discussed include the microwave heating and other processes of materials, which utilize the magnetron predominantly. Other applications include microwave ioni

Fuzzy logic applications in engineering science

CERN Document Server

Harris, J

2006-01-01

Fuzzy logic is a relatively new concept in science applications. Hitherto, fuzzy logic has been a conceptual process applied in the field of risk management. Its potential applicability is much wider than that, however, and its particular suitability for expanding our understanding of processes and information in science and engineering in our post-modern world is only just beginning to be appreciated. Written as a companion text to the author's earlier volume "An Introduction to Fuzzy Logic Applications", the book is aimed at professional engineers and students and those with an interest in exploring the potential of fuzzy logic as an information processing kit with a wide variety of practical applications in the field of engineering science and develops themes and topics introduced in the author's earlier text.

Rock engineering applications, 1991

International Nuclear Information System (INIS)

Franklin, J.A.; Dusseault, M.B.

1991-01-01

This book demonstrates how to apply the theories and principles of rock engineering to actual engineering and construction tasks. It features insights on geology for mining and tunnelling applications. It is practical resource that focuses on the latest technological innovation and examines up-to-date procedures used by engineers for coping with complex rock conditions. The authors also discuss question related to underground space, from design approaches to underground housing and storage. And they cover the monitoring of storage caverns for liquid and gaseous products or toxic and radioactive wastes

Biocatalysts: application and engineering for industrial purposes.

Science.gov (United States)

Jemli, Sonia; Ayadi-Zouari, Dorra; Hlima, Hajer Ben; Bejar, Samir

2016-01-01

Enzymes are widely applied in various industrial applications and processes, including the food and beverage, animal feed, textile, detergent and medical industries. Enzymes screened from natural origins are often engineered before entering the market place because their native forms do not meet the requirements for industrial application. Protein engineering is concerned with the design and construction of novel enzymes with tailored functional properties, including stability, catalytic activity, reaction product inhibition and substrate specificity. Two broad approaches have been used for enzyme engineering, namely, rational design and directed evolution. The powerful and revolutionary techniques so far developed for protein engineering provide excellent opportunities for the design of industrial enzymes with specific properties and production of high-value products at lower production costs. The present review seeks to highlight the major fields of enzyme application and to provide an updated overview on previous protein engineering studies wherein natural enzymes were modified to meet the operational conditions required for industrial application.

Engineering β-sheet peptide assemblies for biomedical applications.

Science.gov (United States)

Yu, Zhiqiang; Cai, Zheng; Chen, Qiling; Liu, Menghua; Ye, Ling; Ren, Jiaoyan; Liao, Wenzhen; Liu, Shuwen

2016-03-01

Hydrogels have been widely studied in various biomedical applications, such as tissue engineering, cell culture, immunotherapy and vaccines, and drug delivery. Peptide-based nanofibers represent a promising new strategy for current drug delivery approaches and cell carriers for tissue engineering. This review focuses on the recent advances in the use of self-assembling engineered β-sheet peptide assemblies for biomedical applications. The applications of peptide nanofibers in biomedical fields, such as drug delivery, tissue engineering, immunotherapy, and vaccines, are highlighted. The current challenges and future perspectives for self-assembling peptide nanofibers in biomedical applications are discussed.

ELECTRICAL TECHNIQUES FOR ENGINEERING APPLICATIONS.

Science.gov (United States)

Bisdorf, Robert J.

1985-01-01

Surface electrical geophysical methods have been used in such engineering applications as locating and delineating shallow gravel deposits, depth to bedrock, faults, clay zones, and other geological phenomena. Other engineering applications include determining water quality, tracing ground water contaminant plumes and locating dam seepages. Various methods and electrode arrays are employed to solve particular geological problems. The sensitivity of a particular method or electrode array depends upon the physics on which the method is based, the array geometry, the electrical contrast between the target and host materials, and the depth to the target. Each of the available electrical methods has its own particular advantages and applications which the paper discusses.

ZnO Nanostructures for Tissue Engineering Applications

Directory of Open Access Journals (Sweden)

Marco Laurenti

2017-11-01

Full Text Available This review focuses on the most recent applications of zinc oxide (ZnO nanostructures for tissue engineering. ZnO is one of the most investigated metal oxides, thanks to its multifunctional properties coupled with the ease of preparing various morphologies, such as nanowires, nanorods, and nanoparticles. Most ZnO applications are based on its semiconducting, catalytic and piezoelectric properties. However, several works have highlighted that ZnO nanostructures may successfully promote the growth, proliferation and differentiation of several cell lines, in combination with the rise of promising antibacterial activities. In particular, osteogenesis and angiogenesis have been effectively demonstrated in numerous cases. Such peculiarities have been observed both for pure nanostructured ZnO scaffolds as well as for three-dimensional ZnO-based hybrid composite scaffolds, fabricated by additive manufacturing technologies. Therefore, all these findings suggest that ZnO nanostructures represent a powerful tool in promoting the acceleration of diverse biological processes, finally leading to the formation of new living tissue useful for organ repair.

Underground engineering applications

International Nuclear Information System (INIS)

Nordyke, M.D.

1969-01-01

Developments of any underground engineering application utilizing nuclear explosives involve answering the same questions one encounters in any new area of technology: What are the characteristics of the new tool? How is it applicable to the job to be done? Is it safe to use? and, most importantly, is its use economically acceptable? The many facets of the answers to these questions will be explored. The general types of application presently under consideration will also be reviewed, with particular emphasis on those specific projects actively being worked on by commercial interests and by the U.S. Atomic Energy Commission. (author)

Underground engineering applications

Energy Technology Data Exchange (ETDEWEB)

Nordyke, M D [Lawrence Radiation Laboratory, Livermore, CA (United States)

1969-07-01

Developments of any underground engineering application utilizing nuclear explosives involve answering the same questions one encounters in any new area of technology: What are the characteristics of the new tool? How is it applicable to the job to be done? Is it safe to use? and, most importantly, is its use economically acceptable? The many facets of the answers to these questions will be explored. The general types of application presently under consideration will also be reviewed, with particular emphasis on those specific projects actively being worked on by commercial interests and by the U.S. Atomic Energy Commission. (author)

Redox cofactor engineering in industrial microorganisms: strategies, recent applications and future directions.

Science.gov (United States)

Liu, Jiaheng; Li, Huiling; Zhao, Guangrong; Caiyin, Qinggele; Qiao, Jianjun

2018-05-01

NAD and NADP, a pivotal class of cofactors, which function as essential electron donors or acceptors in all biological organisms, drive considerable catabolic and anabolic reactions. Furthermore, they play critical roles in maintaining intracellular redox homeostasis. However, many metabolic engineering efforts in industrial microorganisms towards modification or introduction of metabolic pathways, especially those involving consumption, generation or transformation of NAD/NADP, often induce fluctuations in redox state, which dramatically impede cellular metabolism, resulting in decreased growth performance and biosynthetic capacity. Here, we comprehensively review the cofactor engineering strategies for solving the problematic redox imbalance in metabolism modification, as well as their features, suitabilities and recent applications. Some representative examples of in vitro biocatalysis are also described. In addition, we briefly discuss how tools and methods from the field of synthetic biology can be applied for cofactor engineering. Finally, future directions and challenges for development of cofactor redox engineering are presented.

Cognitive engineering in aerospace applications

Science.gov (United States)

Woods, David D.

1993-01-01

The progress that was made with respect to the objectives and goals of the research that is being carried out in the Cognitive Systems Engineering Laboratory (CSEL) under a Cooperative Agreement with NASA Ames Research Center is described. The major objective of this project is to expand the research base in Cognitive Engineering to be able to support the development and human-centered design of automated systems for aerospace applications. This research project is in support of the Aviation Safety/Automation Research plan and related NASA research goals in space applications.

Biomedical applications of control engineering

CERN Document Server

Hacısalihzade, Selim S

2013-01-01

Biomedical Applications of Control Engineering is a lucidly written textbook for graduate control engin­eering and biomedical engineering students as well as for medical prac­ti­tioners who want to get acquainted with quantitative methods. It is based on decades of experience both in control engineering and clinical practice.   The book begins by reviewing basic concepts of system theory and the modeling process. It then goes on to discuss control engineering application areas like ·         Different models for the human operator, ·         Dosage and timing optimization in oral drug administration, ·         Measuring symptoms of and optimal dopaminergic therapy in Parkinson’s disease, ·         Measure­ment and control of blood glucose le­vels both naturally and by means of external controllers in diabetes, and ·         Control of depth of anaesthesia using inhalational anaesthetic agents like sevoflurane using both fuzzy and state feedback controllers....

DESIGN QUALITY IN MECHANICAL ENGINEERING APPLICATION

Directory of Open Access Journals (Sweden)

Ayşegül Akdogan Eker

2010-09-01

Full Text Available There is a close relationship between material chose and quality in mechanical engineering application like there is in all the other engineering applications. If this relation is balanced then engineering success increases. Material chose comes to fore in the design process most of the time. The two most important responsibilities of the design engineer in here is to chose suitable material and to know the production processes about design. The chose of material of a design that will fulfill the needs all through its life has great importance. It is needed to limit the material applicants by choosing the most suitable ones among variable material. Choosing materials that were examined before and whose behavior is well known provides the designer to feel confident. However since using highly successful materials would increase the competitive power of the designs; designers should follow the developments in materials and know the features of new materials. The description of these features can be interpreted within quality. Quality from the point of engineer is the total fulfillment of expectations.Engineer today are faced with very important problems such as fast technological innovations, a dynamic socio-economical environment, global rivalry. One of the life buoys they stick while trying to solve these problems is total method of quality control. Total Quality model which can provide higher competitive power compared to classical management model brings success only when applied with its whole components. "Approach toward prevention" and "measurement and statistics" have an important place among these elements. The first step of the approach toward prevention composes of design quality and Quality Function Deployment (QFD, or in other words The House of Quality method that will provide this. In this paper; considering the quality function deployment, how the chose of material are done in mechanical engineering applications will be explained.

Specification framework for engineering adaptive web applications

NARCIS (Netherlands)

Frasincar, F.; Houben, G.J.P.M.; Vdovják, R.

2002-01-01

The growing demand for data-driven Web applications has led to the need for a structured and controlled approach to the engineering of such applications. Both designers and developers need a framework that in all stages of the engineering process allows them to specify the relevant aspects of the

Industrial and Systems Engineering Applications in NASA

Science.gov (United States)

Shivers, Charles H.

2006-01-01

A viewgraph presentation on the many applications of Industrial and Systems Engineering used for safe NASA missions is shown. The topics include: 1) NASA Information; 2) Industrial Engineering; 3) Systems Engineering; and 4) Major NASA Programs.

Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications.

Science.gov (United States)

Ostrovidov, Serge; Hosseini, Vahid; Ahadian, Samad; Fujie, Toshinori; Parthiban, Selvakumar Prakash; Ramalingam, Murugan; Bae, Hojae; Kaji, Hirokazu; Khademhosseini, Ali

2014-10-01

Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two decades after the introduction of SMTE, the engineering of functional skeletal muscle in the laboratory still remains a great challenge, and numerous techniques for growing functional muscle tissues are constantly being developed. This article reviews the recent findings regarding the methodology and various technical aspects of SMTE, including cell alignment and differentiation. We describe the structure and organization of muscle and discuss the methods for myoblast alignment cultured in vitro. To better understand muscle formation and to enhance the engineering of skeletal muscle, we also address the molecular basics of myogenesis and discuss different methods to induce myoblast differentiation into myotubes. We then provide an overview of different coculture systems involving skeletal muscle cells, and highlight major applications of engineered skeletal muscle tissues. Finally, potential challenges and future research directions for SMTE are outlined.

Lithium-polymer batteries for EV applications. Final report

Energy Technology Data Exchange (ETDEWEB)

Thomas, J.O. [Uppsala Univ. (Sweden). Dept. of Inorganic Chemistry

2000-05-01

The project initially held a strong 'battery materials' profile, but has moved in its final year into more 'battery engineering' aspects; the performances of a range of potential materials have been screened, and candidates have emerged. It is noteworthy that these same materials have also now become 'best-choice' materials in commercial Japanese Li-ion batteries for mobile-phone, lap-top and, more recently, even electric-vehicle (EV) applications. It is now clear that the Li-ion (polymer) battery offers a genuinely viable option in electric and electric-hybrid vehicle concepts. Specifically, our work has involved synthetic, structural, morphological and electrochemical studies of lithium insertion mechanisms in TMO-based cathodes (LiMn{sub 2}O{sub 4}, V{sub 6}O{sub 13}, LiCoO{sub 2}, LiFePO{sub 4}, etc) and graphitic carbon anodes. Performance has been optimised from cell capacity, power, shelf-life and safety viewpoints. Cost has also emerged as a critical variable. Novel methods have been developed within the project for elevated-temperature battery studies (up to 80 deg C); they have become widely applied internationally. The electrode materials which have been developed have subsequently been incorporated into laboratory-scale lithium-ion battery prototypes, whose performance has then been evaluated. The final phase of the project has focussed on a new cathode material (LiFePO{sub 4}) not in current commercial use and yet ideally suited to EV application by virtue of its cheapness, high capacity (ca 170 mAh/g), high voltage vs. Li (3.5V), and extremely flat discharge curve. This could well prove to be the 'best compromise' Li-ion battery cathode for EV applications in the future.

Direct heat applications of geothermal energy in The Geysers/Clear Lake region. Volume I. Geotechnical assessment, agribusiness applications, socioeconomic assessment, engineering assessment. Final report

Energy Technology Data Exchange (ETDEWEB)

1977-08-01

The different uses to which geothermal heat and fluids could be applied as a direct utilization of resource or as heat utilization are explored. The following aspects are covered: geotechnical assessment, agricultural and industrial applications, socioeconomic assessment, and engineering assessment. (MHR)

The impact of improved sparse linear solvers on industrial engineering applications

Energy Technology Data Exchange (ETDEWEB)

Heroux, M. [Cray Research, Inc., Eagan, MN (United States); Baddourah, M.; Poole, E.L.; Yang, Chao Wu

1996-12-31

There are usually many factors that ultimately determine the quality of computer simulation for engineering applications. Some of the most important are the quality of the analytical model and approximation scheme, the accuracy of the input data and the capability of the computing resources. However, in many engineering applications the characteristics of the sparse linear solver are the key factors in determining how complex a problem a given application code can solve. Therefore, the advent of a dramatically improved solver often brings with it dramatic improvements in our ability to do accurate and cost effective computer simulations. In this presentation we discuss the current status of sparse iterative and direct solvers in several key industrial CFD and structures codes, and show the impact that recent advances in linear solvers have made on both our ability to perform challenging simulations and the cost of those simulations. We also present some of the current challenges we have and the constraints we face in trying to improve these solvers. Finally, we discuss future requirements for sparse linear solvers on high performance architectures and try to indicate the opportunities that exist if we can develop even more improvements in linear solver capabilities.

Intelligent techniques in engineering management theory and applications

CERN Document Server

Onar, Sezi

2015-01-01

This book presents recently developed intelligent techniques with applications and theory in the area of engineering management. The involved applications of intelligent techniques such as neural networks, fuzzy sets, Tabu search, genetic algorithms, etc. will be useful for engineering managers, postgraduate students, researchers, and lecturers. The book has been written considering the contents of a classical engineering management book but intelligent techniques are used for handling the engineering management problem areas. This comprehensive characteristics of the book makes it an excellent reference for the solution of complex problems of engineering management. The authors of the chapters are well-known researchers with their previous works in the area of engineering management.

Aloe Vera for Tissue Engineering Applications

Directory of Open Access Journals (Sweden)

Shekh Rahman

2017-02-01

Full Text Available Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

Aloe Vera for Tissue Engineering Applications.

Science.gov (United States)

Rahman, Shekh; Carter, Princeton; Bhattarai, Narayan

2017-02-14

Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

Engineering Stem Cells for Biomedical Applications

Science.gov (United States)

Yin, Perry T.; Han, Edward

2018-01-01

Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recently, efforts have focused on engineering stem cells in order to further enhance their innate abilities as well as to confer them with new functionalities, which can then be used in various biomedical applications. These engineered stem cells can take on a number of forms. For instance, engineered stem cells encompass the genetic modification of stem cells as well as the use of stem cells for gene delivery, nanoparticle loading and delivery, and even small molecule drug delivery. The present Review gives an in-depth account of the current status of engineered stem cells, including potential cell sources, the most common methods used to engineer stem cells, and the utilization of engineered stem cells in various biomedical applications, with a particular focus on tissue regeneration, the treatment of immunodeficiency diseases, and cancer. PMID:25772134

Engineering Stem Cells for Biomedical Applications.

Science.gov (United States)

Yin, Perry T; Han, Edward; Lee, Ki-Bum

2016-01-07

Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recently, efforts have focused on engineering stem cells in order to further enhance their innate abilities as well as to confer them with new functionalities, which can then be used in various biomedical applications. These engineered stem cells can take on a number of forms. For instance, engineered stem cells encompass the genetic modification of stem cells as well as the use of stem cells for gene delivery, nanoparticle loading and delivery, and even small molecule drug delivery. The present Review gives an in-depth account of the current status of engineered stem cells, including potential cell sources, the most common methods used to engineer stem cells, and the utilization of engineered stem cells in various biomedical applications, with a particular focus on tissue regeneration, the treatment of immunodeficiency diseases, and cancer. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recent advances in electrical engineering and control applications

CERN Document Server

Bououden, Sofiane; Zelinka, Ivan

2017-01-01

This book of proceedings includes papers presenting the state of art in electrical engineering and control theory as well as their applications. The topics focus on classical as well as modern methods for modeling, control, identification and simulation of complex systems with applications in science and engineering. The papers were selected from the hottest topic areas, such as control and systems engineering, renewable energy, faults diagnosis—faults tolerant control, large-scale systems, fractional order systems, unconventional algorithms in control engineering, signals and communications. The control and design of complex systems dynamics, analysis and modeling of its behavior and structure is vitally important in engineering, economics and in science generally science today. Examples of such systems can be seen in the world around us and are a part of our everyday life. Application of modern methods for control, electronics, signal processing and more can be found in our mobile phones, car engines, hom...

A review of free-piston engine history and applications

Energy Technology Data Exchange (ETDEWEB)

Mikalsen, R.; Roskilly, A.P. [School of Marine Science and Technology, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU (United Kingdom)

2007-10-15

This document reviews the history of free-piston internal combustion engines, from the air compressors and gas generators used in the mid-20th century through to recent free-piston hydraulic engines and linear electric generators. Unique features of the free-piston engine are presented and their effects on engine operation are discussed, along with potential advantages and disadvantages compared to conventional engines. The paper focuses mainly on developed engines where operational data has been reported. Finally, the potential of the free-piston engine is evaluated and the most promising designs identified. (author)

An historical perspective of the NERVA nuclear rocket engine technology program. Final Report

International Nuclear Information System (INIS)

Robbins, W.H.; Finger, H.B.

1991-07-01

Nuclear rocket research and development was initiated in the United States in 1955 and is still being pursued to a limited extent. The major technology emphasis occurred in the decade of the 1960s and was primarily associated with the Rover/NERVA Program where the technology for a nuclear rocket engine system for space application was developed and demonstrated. The NERVA (Nuclear Engine for Rocket Vehicle Application) technology developed twenty years ago provides a comprehensive and viable propulsion technology base that can be applied and will prove to be valuable for application to the NASA Space Exploration Initiative (SEI). This paper, which is historical in scope, provides an overview of the conduct of the NERVA Engine Program, its organization and management, development philosophy, the engine configuration, and significant accomplishments

Applications of sliding mode control in science and engineering

CERN Document Server

Lien, Chang-Hua

2017-01-01

Gathering 20 chapters contributed by respected experts, this book reports on the latest advances in and applications of sliding mode control in science and engineering. The respective chapters address applications of sliding mode control in the broad areas of chaos theory, robotics, electrical engineering, physics, chemical engineering, memristors, mechanical engineering, environmental engineering, finance, and biology. Special emphasis has been given to papers that offer practical solutions, and which examine design and modeling involving new types of sliding mode control such as higher order sliding mode control, terminal sliding mode control, super-twisting sliding mode control, and integral sliding mode control. This book serves as a unique reference guide to sliding mode control and its recent applications for graduate students and researchers with a basic knowledge of electrical and control systems engineering.

Optimization strategies for complex engineering applications

Energy Technology Data Exchange (ETDEWEB)

Eldred, M.S.

1998-02-01

LDRD research activities have focused on increasing the robustness and efficiency of optimization studies for computationally complex engineering problems. Engineering applications can be characterized by extreme computational expense, lack of gradient information, discrete parameters, non-converging simulations, and nonsmooth, multimodal, and discontinuous response variations. Guided by these challenges, the LDRD research activities have developed application-specific techniques, fundamental optimization algorithms, multilevel hybrid and sequential approximate optimization strategies, parallel processing approaches, and automatic differentiation and adjoint augmentation methods. This report surveys these activities and summarizes the key findings and recommendations.

Protein engineering and its applications in food industry.

Science.gov (United States)

Kapoor, Swati; Rafiq, Aasima; Sharma, Savita

2017-07-24

Protein engineering is a young discipline that has been branched out from the field of genetic engineering. Protein engineering is based on the available knowledge about the proteins structure/function(s), tools/instruments, software, bioinformatics database, available cloned gene, knowledge about available protein, vectors, recombinant strains and other materials that could lead to change in the protein backbone. Protein produced properly from genetic engineering process means a protein that is able to fold correctly and to do particular function(s) efficiently even after being subjected to engineering practices. Protein is modified through its gene or chemically. However, modification of protein through gene is easier. There is no specific limitation of Protein Engineering tools; any technique that can lead to change the protein constituent of amino acid and result in the modification of protein structure/function is in the frame of Protein Engineering. Meanwhile, there are some common tools used to reach a specific target. More active industrial and pharmaceutical based proteins have been invented by the field of Protein Engineering to introduce new function as well as to change its interaction with surrounding environment. A variety of protein engineering applications have been reported in the literature. These applications range from biocatalysis for food and industry to environmental, medical and nanobiotechnology applications. Successful combinations of various protein engineering methods had led to successful results in food industries and have created a scope to maintain the quality of finished product after processing.

Application and Evaluation of Control Modes for Risk-Based Engine Performance Enhancements

Science.gov (United States)

Liu, Yuan; Litt, Jonathan S.; Sowers, T. Shane; Owen, A. Karl; Guo, Ten-Huei

2015-01-01

The engine control system for civil transport aircraft imposes operational limits on the propulsion system to ensure compliance with safety standards. However, during certain emergency situations, aircraft survivability may benefit from engine performance beyond its normal limits despite the increased risk of failure. Accordingly, control modes were developed to improve the maximum thrust output and responsiveness of a generic high-bypass turbofan engine. The algorithms were designed such that the enhanced performance would always constitute an elevation in failure risk to a consistent predefined likelihood. This paper presents an application of these risk-based control modes to a combined engine/aircraft model. Through computer and piloted simulation tests, the aim is to present a notional implementation of these modes, evaluate their effects on a generic airframe, and demonstrate their usefulness during emergency flight situations. Results show that minimal control effort is required to compensate for the changes in flight dynamics due to control mode activation. The benefits gained from enhanced engine performance for various runway incursion scenarios are investigated. Finally, the control modes are shown to protect against potential instabilities during propulsion-only flight where all aircraft control surfaces are inoperable.

International conference on Information Engineering and Applications (IEA) 2012

CERN Document Server

2013-01-01

Information engineering and applications is the field of study concerned with constructing information computing, intelligent systems, mathematical models, numerical solution techniques, and using computers and other electronic devices to analyze and solve natural scientific, social scientific and engineering problems.   Information engineering is an important underpinning for techniques used in information and computational science and there are many unresolved problems worth studying. The Proceedings of the 2nd International Conference on Information Engineering and Applications (IEA 2012), which was held in Chongqing, China, from October 26-28, 2012, discusses the most innovative research and developments including technical challenges and social, legal, political, and economic issues.   A forum for engineers and scientists in academia, industry, and government, the Proceedings of the 2nd International Conference on Information Engineering and Applications presents ideas, results, works in progress, and ...

Parallel science and engineering applications the Charm++ approach

CERN Document Server

Kale, Laxmikant V

2016-01-01

Developed in the context of science and engineering applications, with each abstraction motivated by and further honed by specific application needs, Charm++ is a production-quality system that runs on almost all parallel computers available. Parallel Science and Engineering Applications: The Charm++ Approach surveys a diverse and scalable collection of science and engineering applications, most of which are used regularly on supercomputers by scientists to further their research. After a brief introduction to Charm++, the book presents several parallel CSE codes written in the Charm++ model, along with their underlying scientific and numerical formulations, explaining their parallelization strategies and parallel performance. These chapters demonstrate the versatility of Charm++ and its utility for a wide variety of applications, including molecular dynamics, cosmology, quantum chemistry, fracture simulations, agent-based simulations, and weather modeling. The book is intended for a wide audience of people i...

Engineered Nanoparticles and Their Applications

International Nuclear Information System (INIS)

Matsoukas, T.; Desai, T.; Lee, K.

2015-01-01

Nanoparticles engineered for shape, size, and surface properties impart special functionalities including catalytic behavior, improved strength, enhanced thermal and electrical conductivity, and controlled release of host molecules. These advances have opened up applications in biomedicine, nano energetic materials, and functional nano composites. This special issue highlights successes in developing nanoparticles for a number of diverse applications.

Surface electromyography physiology, engineering and applications

CERN Document Server

Farina, Dario

2016-01-01

The book presents a quantitative approach to the study and use of noninvasively detected electromyographic (EMG) signals, as well as their numerous applications in various aspects of the life sciences. Surface Electromyography: Physiology, Engineering, and Applications is an update of Electromyography: Physiology, Engineering, and Noninvasive Applications (Wiley-IEEE Press, 2004) and focuses on the developments that have taken place over the last decade. The first nine chapters deal with the generation, detection, understanding, interpretation, and modeling of EMG signals. Detection technology, with particular focus on EMG imaging techniques that are based on two-dimensional electrode arrays are also included in the first half of the book. The latter 11 chapters deal with applications, which range fro monitoring muscle fatigue, electrically elicited contractions, posture analysis, prevention of work-related and child-delivery-related neuromuscular disorders, ergonomics, movement analysis, physical therapy, ex...

Applications of human factors engineering to LNG release prevention and control

Energy Technology Data Exchange (ETDEWEB)

Shikiar, R.; Rankin, W.L.; Rideout, T.B.

1982-06-01

The results of an investigation of human factors engineering and human reliability applications to LNG release prevention and control are reported. The report includes a discussion of possible human error contributions to previous LNG accidents and incidents, and a discussion of generic HF considerations for peakshaving plants. More specific recommendations for improving HF practices at peakshaving plants are offered based on visits to six facilities. The HF aspects of the recently promulgated DOT regulations are reviewed, and recommendations are made concerning how these regulations can be implemented utilizing standard HF practices. Finally, the integration of HF considerations into overall system safety is illustrated by a presentation of human error probabilities applicable to LNG operations and by an expanded fault tree analysis which explicitly recognizes man-machine interfaces.

46 CFR 113.35-15 - Mechanical engine order telegraph systems; application.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Mechanical engine order telegraph systems; application...) ELECTRICAL ENGINEERING COMMUNICATION AND ALARM SYSTEMS AND EQUIPMENT Engine Order Telegraph Systems § 113.35-15 Mechanical engine order telegraph systems; application. If a mechanical engine order telegraph...

Engine testing of ceramic cam-roller followers. Final report

Energy Technology Data Exchange (ETDEWEB)

Kalish, Y. [Detroit Diesel Corp., MI (United States)

1992-04-01

For several years, DDC has been developing monolithic ceramic heat engine components. One of the components, developed for an application in our state-of-the-art on-highway, heavy-duty diesel engine, the Series 60, is a silicon nitride cam-roller follower. Prior to starting this program, each valve train component in the Series 60 was considered for conversion to a ceramic material. Many advantages and disadvantages (benefits and risks) were considered. From this effort, one component was selected, the cam-roller follower. Using a system design approach, a ceramic cam-roller follower offered functional improvement at a reasonable cost. The purpose of the project was to inspect and test 100 domestically produced silicon nitride cam-roller followers built to the requirements of the DDC series 60 engine.

Engineering development of advanced froth flotation. Volume 2, Final report

Energy Technology Data Exchange (ETDEWEB)

Ferris, D.D.; Bencho, J.R.; Torak, E.R. [ICF Kaiser Engineers, Inc., Pittsburgh, PA (United States)

1995-03-01

This report is an account of findings related to the Engineering and Development of Advanced Froth Flotation project. The results from benchscale and proof-of-concept (POC) level testing are presented and the important results from this testing are used to refine a conceptual design and cost estimate for a 20 TPH Semi-Works Facility incorporating the final proposed technology.

Analytical benchmarks for nuclear engineering applications. Case studies in neutron transport theory

International Nuclear Information System (INIS)

2008-01-01

The developers of computer codes involving neutron transport theory for nuclear engineering applications seldom apply analytical benchmarking strategies to ensure the quality of their programs. A major reason for this is the lack of analytical benchmarks and their documentation in the literature. The few such benchmarks that do exist are difficult to locate, as they are scattered throughout the neutron transport and radiative transfer literature. The motivation for this benchmark compendium, therefore, is to gather several analytical benchmarks appropriate for nuclear engineering applications under one cover. We consider the following three subject areas: neutron slowing down and thermalization without spatial dependence, one-dimensional neutron transport in infinite and finite media, and multidimensional neutron transport in a half-space and an infinite medium. Each benchmark is briefly described, followed by a detailed derivation of the analytical solution representation. Finally, a demonstration of the evaluation of the solution representation includes qualified numerical benchmark results. All accompanying computer codes are suitable for the PC computational environment and can serve as educational tools for courses in nuclear engineering. While this benchmark compilation does not contain all possible benchmarks, by any means, it does include some of the most prominent ones and should serve as a valuable reference. (author)

Practical Application of Sociology in Systems Engineering

Science.gov (United States)

Watson, Michael D.; Andrews, James G.; Eckley, Jeri Cassel; Culver, Michael L.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, who often have different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated will all relevant information informing system decisions. The practical application of the sociology in systems engineering brings in various organizational development concepts including the principles of planned renegotiation and the application of principles to address information barriers created by organizational culture. Concepts such as specification of ignorance, consistent terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that help address the organizational social structure (culture). In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, and insider-outsider behavior. Unintended consequences can result when these social issues are present. These issues can occur when localized subcultures shift from the overarching organizational culture, or when the organizational culture prevents achievement of system goals. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information and provides key sociological barriers to information flow through the organization. This paper will discuss the practical application of sociological principles to systems engineering.

Optoisolation circuits nonlinearity applications in engineering : optoisolation nonlinear dynamics and chaos, application in engineering

CERN Document Server

Aluf, Ofer

2012-01-01

This book describes a new concept in analyzing circuits, which includes optoisolation elements. The analysis is based on nonlinear dynamics and chaos models and shows comprehensive benefits and results. All conceptual optoisolation circuits are innovative and can be broadly implemented in engineering applications. The dynamics of optoisolation circuits provides several ways to use them in a variety of applications covering wide areas. The presentation fills the gap of analytical methods for optoisolation circuits analysis, concrete examples, and geometric examples. The optoisolation circuits analysis is developed systematically, starting with basic optoisolation circuits differential equations and their bifurcations, followed by Fixed points analysis, limit cycles and their bifurcations. Optoisolation circuits can be characterized as Lorenz equations, chaos, iterated maps, period doubling and attractors. This book is aimed at electrical and electronic engineers, students and researchers in physics as well. A ...

Engineering derivatives from biological systems for advanced aerospace applications

Science.gov (United States)

Winfield, Daniel L.; Hering, Dean H.; Cole, David

1991-01-01

The present study consisted of a literature survey, a survey of researchers, and a workshop on bionics. These tasks produced an extensive annotated bibliography of bionics research (282 citations), a directory of bionics researchers, and a workshop report on specific bionics research topics applicable to space technology. These deliverables are included as Appendix A, Appendix B, and Section 5.0, respectively. To provide organization to this highly interdisciplinary field and to serve as a guide for interested researchers, we have also prepared a taxonomy or classification of the various subelements of natural engineering systems. Finally, we have synthesized the results of the various components of this study into a discussion of the most promising opportunities for accelerated research, seeking solutions which apply engineering principles from natural systems to advanced aerospace problems. A discussion of opportunities within the areas of materials, structures, sensors, information processing, robotics, autonomous systems, life support systems, and aeronautics is given. Following the conclusions are six discipline summaries that highlight the potential benefits of research in these areas for NASA's space technology programs.

Handbook of bioplastics and biocomposites engineering applications

National Research Council Canada - National Science Library

Pilla, Srikanth

2011-01-01

"The Handbook of Bioplastics & Biocomposites Engineering Applications brings together scientists, from academia and industries, to report on current research and applications, in the bioplastics and biocomposites arena...

Biomedical applications engineering tasks

Science.gov (United States)

Laenger, C. J., Sr.

1976-01-01

The engineering tasks performed in response to needs articulated by clinicians are described. Initial contacts were made with these clinician-technology requestors by the Southwest Research Institute NASA Biomedical Applications Team. The basic purpose of the program was to effectively transfer aerospace technology into functional hardware to solve real biomedical problems.

Stirling Space Engine Program. Volume 1; Final Report

Science.gov (United States)

Dhar, Manmohan

1999-01-01

The objective of this program was to develop the technology necessary for operating Stirling power converters in a space environment and to demonstrate this technology in full-scale engine tests. Hardware development focused on the Component Test Power Converter (CTPC), a single cylinder, 12.5-kWe engine. Design parameters for the CTPC were 150 bar operating pressure, 70 Hz frequency, and hot-and cold-end temperatures of 1050 K and 525 K, respectively. The CTPC was also designed for integration with an annular sodium heat pipe at the hot end, which incorporated a unique "Starfish" heater head that eliminated highly stressed brazed or weld joints exposed to liquid metal and used a shaped-tubed electrochemical milling process to achieve precise positional tolerances. Selection of materials that could withstand high operating temperatures with long life were another focus. Significant progress was made in the heater head (Udimet 700 and Inconel 718 and a sodium-filled heat pipe); the alternator (polyimide-coated wire with polyimide adhesive between turns and a polyimide-impregnated fiberglass overwrap and samarium cobalt magnets); and the hydrostatic gas bearings (carbon graphite and aluminum oxide for wear couple surfaces). Tests on the CTPC were performed in three phases: cold end testing (525 K), engine testing with slot radiant heaters, and integrated heat pipe engine system testing. Each test phase was successful, with the integrated engine system demonstrating a power level of 12.5 kWe and an overall efficiency of 22 percent in its maiden test. A 1500-hour endurance test was then successfully completed. These results indicate the significant achievements made by this program that demonstrate the viability of Stirling engine technology for space applications.

Programmable lithography engine (ProLE) grid-type supercomputer and its applications

Science.gov (United States)

Petersen, John S.; Maslow, Mark J.; Gerold, David J.; Greenway, Robert T.

2003-06-01

There are many variables that can affect lithographic dependent device yield. Because of this, it is not enough to make optical proximity corrections (OPC) based on the mask type, wavelength, lens, illumination-type and coherence. Resist chemistry and physics along with substrate, exposure, and all post-exposure processing must be considered too. Only a holistic approach to finding imaging solutions will accelerate yield and maximize performance. Since experiments are too costly in both time and money, accomplishing this takes massive amounts of accurate simulation capability. Our solution is to create a workbench that has a set of advanced user applications that utilize best-in-class simulator engines for solving litho-related DFM problems using distributive computing. Our product, ProLE (Programmable Lithography Engine), is an integrated system that combines Petersen Advanced Lithography Inc."s (PAL"s) proprietary applications and cluster management software wrapped around commercial software engines, along with optional commercial hardware and software. It uses the most rigorous lithography simulation engines to solve deep sub-wavelength imaging problems accurately and at speeds that are several orders of magnitude faster than current methods. Specifically, ProLE uses full vector thin-mask aerial image models or when needed, full across source 3D electromagnetic field simulation to make accurate aerial image predictions along with calibrated resist models;. The ProLE workstation from Petersen Advanced Lithography, Inc., is the first commercial product that makes it possible to do these intensive calculations at a fraction of a time previously available thus significantly reducing time to market for advance technology devices. In this work, ProLE is introduced, through model comparison to show why vector imaging and rigorous resist models work better than other less rigorous models, then some applications of that use our distributive computing solution are shown

Final Rule for Nonconformance Penalties for On-Highway Heavy-Duty Diesel Engines

Science.gov (United States)

EPA is taking final action to establish nonconformance penalties (NCPs) for manufacturers of heavy heavy-duty diesel engines (HHDDE) in model years 2012 and later for emissions of oxides of nitrogen (NOX) because we have found the criteria for NCPs.

NASA Applications and Lessons Learned in Reliability Engineering

Science.gov (United States)

Safie, Fayssal M.; Fuller, Raymond P.

2011-01-01

Since the Shuttle Challenger accident in 1986, communities across NASA have been developing and extensively using quantitative reliability and risk assessment methods in their decision making process. This paper discusses several reliability engineering applications that NASA has used over the year to support the design, development, and operation of critical space flight hardware. Specifically, the paper discusses several reliability engineering applications used by NASA in areas such as risk management, inspection policies, components upgrades, reliability growth, integrated failure analysis, and physics based probabilistic engineering analysis. In each of these areas, the paper provides a brief discussion of a case study to demonstrate the value added and the criticality of reliability engineering in supporting NASA project and program decisions to fly safely. Examples of these case studies discussed are reliability based life limit extension of Shuttle Space Main Engine (SSME) hardware, Reliability based inspection policies for Auxiliary Power Unit (APU) turbine disc, probabilistic structural engineering analysis for reliability prediction of the SSME alternate turbo-pump development, impact of ET foam reliability on the Space Shuttle System risk, and reliability based Space Shuttle upgrade for safety. Special attention is given in this paper to the physics based probabilistic engineering analysis applications and their critical role in evaluating the reliability of NASA development hardware including their potential use in a research and technology development environment.

Refresher Course on Tensors and their Applications in Engineering ...

Indian Academy of Sciences (India)

Applications in Engineering Sciences. Department of Mechanical Engineering, Indian Institute of Science, Bangalore. December 11-23,2006 sponsored by Indian Academy of Sciences, Bangalore in collaboration with Indian Institute of Science, Bangalore. Applications are invited from University/College teachers, Research ...

Ceramics for Turbine Engine Applications.

Science.gov (United States)

1980-03-01

permet de travailler en compression. 2 - LES TURBINES CONTRAROTATIVES Connues depuis plus de 50 ans dsns lea turbines A vapeur (A grilles radiales) lea...AD-AO87 594 ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT--ETC F/6 11/2 CERAMICS FOR TURBINE ENGINE APPICATIONS.(U) MAR 8G H M GURTE, J...for Turbine Engine Applications ( X.,, ~LAJ DISTRIBUTION AND AVAILABILITY Ths ai’-t~ ~ru O ACK COVER forp"~ ~So’ 8 6 0 40 NORTH ATLANTIC TREATY

Final report of the ITER EDA. Final report of the ITER Engineering Design Activities. Prepared by the ITER Council

International Nuclear Information System (INIS)

2001-01-01

This is the Final Report by the ITER Council on work carried out by ITER participating countries on cooperation in the Engineering Design Activities (EDA) for the ITER. In this report the main ITER EDA technical objectives, the scope of ITER EDA, its organization and resources, engineering design of ITER tokamak and its main parameters are presented. This Report also includes safety and environmental assessments, site requirements and proposed schedule and estimates of manpower and cost as well as proposals on approaches to joint implementation of the project

Mathematical modeling and computational intelligence in engineering applications

CERN Document Server

Silva Neto, Antônio José da; Silva, Geraldo Nunes

2016-01-01

This book brings together a rich selection of studies in mathematical modeling and computational intelligence, with application in several fields of engineering, like automation, biomedical, chemical, civil, electrical, electronic, geophysical and mechanical engineering, on a multidisciplinary approach. Authors from five countries and 16 different research centers contribute with their expertise in both the fundamentals and real problems applications based upon their strong background on modeling and computational intelligence. The reader will find a wide variety of applications, mathematical and computational tools and original results, all presented with rigorous mathematical procedures. This work is intended for use in graduate courses of engineering, applied mathematics and applied computation where tools as mathematical and computational modeling, numerical methods and computational intelligence are applied to the solution of real problems.

Nuclear engineering career - Phase 2 Argentina. Final report

International Nuclear Information System (INIS)

1993-01-01

The objective of the project was to consolidate and extend the conditions necessary for the development of nuclear technology, and to observe the problems posed by the application of the nuclear energy through the increase and improvement of the scientific and technical infrastructure. The immediate objective of the project was to complete the advancement of research and development activities in nuclear engineering at the Centro Atomico Bariloche and Instituto Balseiro

Survey on Recent Research and Implementation of Ant Colony Optimization in Various Engineering Applications

Directory of Open Access Journals (Sweden)

Mohan B. Chandra

2011-08-01

Full Text Available Ant colony optimization (ACO takes inspiration from the foraging behaviour of real ant species. This ACO exploits a similar mechanism for solving optimization problems for the various engineering field of study. Many successful implementations using ACO are now available in many applications. This paper reviewing varies systematic approach on recent research and implementation of ACO. Finally it presents the experimental result of ACO which is applied for routing problem and compared with existing algorithms.

Engineering Adaptive Web Applications

DEFF Research Database (Denmark)

Dolog, Peter

2007-01-01

suit the user profile the most. This paper summarizes the domain engineering framework for such adaptive web applications. The framework provides guidelines to develop adaptive web applications as members of a family. It suggests how to utilize the design artifacts as knowledge which can be used......Information and services on the web are accessible for everyone. Users of the web differ in their background, culture, political and social environment, interests and so on. Ambient intelligence was envisioned as a concept for systems which are able to adapt to user actions and needs....... With the growing amount of information and services, the web applications become natural candidates to adopt the concepts of ambient intelligence. Such applications can deal with divers user intentions and actions based on the user profile and can suggest the combination of information content and services which...

Advances in polymeric systems for tissue engineering and biomedical applications.

Science.gov (United States)

Ravichandran, Rajeswari; Sundarrajan, Subramanian; Venugopal, Jayarama Reddy; Mukherjee, Shayanti; Ramakrishna, Seeram

2012-03-01

The characteristics of tissue engineered scaffolds are major concerns in the quest to fabricate ideal scaffolds for tissue engineering applications. The polymer scaffolds employed for tissue engineering applications should possess multifunctional properties such as biocompatibility, biodegradability and favorable mechanical properties as it comes in direct contact with the body fluids in vivo. Additionally, the polymer system should also possess biomimetic architecture and should support stem cell adhesion, proliferation and differentiation. As the progress in polymer technology continues, polymeric biomaterials have taken characteristics more closely related to that desired for tissue engineering and clinical needs. Stimuli responsive polymers also termed as smart biomaterials respond to stimuli such as pH, temperature, enzyme, antigen, glucose and electrical stimuli that are inherently present in living systems. This review highlights the exciting advancements in these polymeric systems that relate to biological and tissue engineering applications. Additionally, several aspects of technology namely scaffold fabrication methods and surface modifications to confer biological functionality to the polymers have also been discussed. The ultimate objective is to emphasize on these underutilized adaptive behaviors of the polymers so that novel applications and new generations of smart polymeric materials can be realized for biomedical and tissue engineering applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Applications of metaheuristic optimization algorithms in civil engineering

CERN Document Server

Kaveh, A

2017-01-01

The book presents recently developed efficient metaheuristic optimization algorithms and their applications for solving various optimization problems in civil engineering. The concepts can also be used for optimizing problems in mechanical and electrical engineering.

Incorporating unnatural amino acids to engineer biocatalysts for industrial bioprocess applications.

Science.gov (United States)

Ravikumar, Yuvaraj; Nadarajan, Saravanan Prabhu; Hyeon Yoo, Tae; Lee, Chong-Soon; Yun, Hyungdon

2015-12-01

The bioprocess engineering with biocatalysts broadly spans its development and actual application of enzymes in an industrial context. Recently, both the use of bioprocess engineering and the development and employment of enzyme engineering techniques have been increasing rapidly. Importantly, engineering techniques that incorporate unnatural amino acids (UAAs) in vivo has begun to produce enzymes with greater stability and altered catalytic properties. Despite the growth of this technique, its potential value in bioprocess applications remains to be fully exploited. In this review, we explore the methodologies involved in UAA incorporation as well as ways to synthesize these UAAs. In addition, we summarize recent efforts to increase the yield of UAA engineered proteins in Escherichia coli and also the application of this tool in enzyme engineering. Furthermore, this protein engineering tool based on the incorporation of UAA can be used to develop immobilized enzymes that are ideal for bioprocess applications. Considering the potential of this tool and by exploiting these engineered enzymes, we expect the field of bioprocess engineering to open up new opportunities for biocatalysis in the near future. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Applications of the discrete element method in mechanical engineering

International Nuclear Information System (INIS)

Fleissner, Florian; Gaugele, Timo; Eberhard, Peter

2007-01-01

Compared to other fields of engineering, in mechanical engineering, the Discrete Element Method (DEM) is not yet a well known method. Nevertheless, there is a variety of simulation problems where the method has obvious advantages due to its meshless nature. For problems where several free bodies can collide and break after having been largely deformed, the DEM is the method of choice. Neighborhood search and collision detection between bodies as well as the separation of large solids into smaller particles are naturally incorporated in the method. The main DEM algorithm consists of a relatively simple loop that basically contains the three substeps contact detection, force computation and integration. However, there exists a large variety of different algorithms to choose the substeps to compose the optimal method for a given problem. In this contribution, we describe the dynamics of particle systems together with appropriate numerical integration schemes and give an overview over different types of particle interactions that can be composed to adapt the method to fit to a given simulation problem. Surface triangulations are used to model complicated, non-convex bodies in contact with particle systems. The capabilities of the method are finally demonstrated by means of application examples

Engineering noble metal nanomaterials for environmental applications

Science.gov (United States)

Li, Jingguo; Zhao, Tingting; Chen, Tiankai; Liu, Yanbiao; Ong, Choon Nam; Xie, Jianping

2015-04-01

Besides being valuable assets in our daily lives, noble metals (namely, gold, silver, and platinum) also feature many intriguing physical and chemical properties when their sizes are reduced to the nano- or even subnano-scale; such assets may significantly increase the values of the noble metals as functional materials for tackling important societal issues related to human health and the environment. Among which, designing/engineering of noble metal nanomaterials (NMNs) to address challenging issues in the environment has attracted recent interest in the community. In general, the use of NMNs for environmental applications is highly dependent on the physical and chemical properties of NMNs. Such properties can be readily controlled by tailoring the attributes of NMNs, including their size, shape, composition, and surface. In this feature article, we discuss recent progress in the rational design and engineering of NMNs with particular focus on their applications in the field of environmental sensing and catalysis. The development of functional NMNs for environmental applications is highly interdisciplinary, which requires concerted efforts from the communities of materials science, chemistry, engineering, and environmental science.

Engineering noble metal nanomaterials for environmental applications.

Science.gov (United States)

Li, Jingguo; Zhao, Tingting; Chen, Tiankai; Liu, Yanbiao; Ong, Choon Nam; Xie, Jianping

2015-05-07

Besides being valuable assets in our daily lives, noble metals (namely, gold, silver, and platinum) also feature many intriguing physical and chemical properties when their sizes are reduced to the nano- or even subnano-scale; such assets may significantly increase the values of the noble metals as functional materials for tackling important societal issues related to human health and the environment. Among which, designing/engineering of noble metal nanomaterials (NMNs) to address challenging issues in the environment has attracted recent interest in the community. In general, the use of NMNs for environmental applications is highly dependent on the physical and chemical properties of NMNs. Such properties can be readily controlled by tailoring the attributes of NMNs, including their size, shape, composition, and surface. In this feature article, we discuss recent progress in the rational design and engineering of NMNs with particular focus on their applications in the field of environmental sensing and catalysis. The development of functional NMNs for environmental applications is highly interdisciplinary, which requires concerted efforts from the communities of materials science, chemistry, engineering, and environmental science.

Application of value engineering technique in construction project

International Nuclear Information System (INIS)

Chen Changbing

2003-01-01

The author introduces how to apply the theories and methods of the value engineering in construction project. In the construction of a test device of the thermal hydrodynamic process, the authors have greatly reduced the construction cost and shortened the construction period by using the value engineering analyzing method. The application of value engineering in the project management is innovative. This practice indicates that the value engineering is important in many construction projects

Photonics Applications and Web Engineering: WILGA 2017

Science.gov (United States)

Romaniuk, Ryszard S.

2017-08-01

XLth Wilga Summer 2017 Symposium on Photonics Applications and Web Engineering was held on 28 May-4 June 2017. The Symposium gathered over 350 participants, mainly young researchers active in optics, optoelectronics, photonics, modern optics, mechatronics, applied physics, electronics technologies and applications. There were presented around 300 oral and poster papers in a few main topical tracks, which are traditional for Wilga, including: bio-photonics, optical sensory networks, photonics-electronics-mechatronics co-design and integration, large functional system design and maintenance, Internet of Things, measurement systems for astronomy, high energy physics experiments, and other. The paper is a traditional introduction to the 2017 WILGA Summer Symposium Proceedings, and digests some of the Symposium chosen key presentations. This year Symposium was divided to the following topical sessions/conferences: Optics, Optoelectronics and Photonics, Computational and Artificial Intelligence, Biomedical Applications, Astronomical and High Energy Physics Experiments Applications, Material Research and Engineering, and Advanced Photonics and Electronics Applications in Research and Industry.

In situ vitrification application to buried waste: Final report of intermediate field tests at Idaho National Engineering Laboratory

International Nuclear Information System (INIS)

Callow, R.A.; Weidner, J.R.; Loehr, C.A.; Bates, S.O.; Thompson, L.E.; McGrail, B.P.

1991-08-01

This report describes two in situ vitrification field tests conducted on simulated buried waste pits during June and July 1990 at the Idaho National Engineering Laboratory. In situ vitrification, an emerging technology for in place conversion of contaminated soils into a durable glass and crystalline waste form, is being investigated as a potential remediation technology for buried waste. The overall objective of the two tests was to access the general suitability of the process to remediate waste structures representative of buried waste found at Idaho National Engineering Laboratory. In particular, these tests, as part of a treatability study, were designed to provide essential information on the field performance of the process under conditions of significant combustible and metal wastes and to test a newly developed electrode feed technology. The tests were successfully completed, and the electrode feed technology successfully processed the high metal content waste. Test results indicate the process is a feasible technology for application to buried waste. 33 refs., 109 figs., 39 tabs

Statistics and probability with applications for engineers and scientists

CERN Document Server

Gupta, Bhisham C

2013-01-01

Introducing the tools of statistics and probability from the ground up An understanding of statistical tools is essential for engineers and scientists who often need to deal with data analysis over the course of their work. Statistics and Probability with Applications for Engineers and Scientists walks readers through a wide range of popular statistical techniques, explaining step-by-step how to generate, analyze, and interpret data for diverse applications in engineering and the natural sciences. Unique among books of this kind, Statistics and Prob

Application of systems engineering: An acquisition agent perspective

CSIR Research Space (South Africa)

Niken, A

2014-10-01

Full Text Available This article covers a descriptive case study on the application of systems engineering and systems engineering management at Armscor. The report also covers the investigation into development methods used and the how the requirements changes...

Application of systems engineering: An acquisition agent perspective

CSIR Research Space (South Africa)

Niken, A

2014-09-01

Full Text Available This article covers a descriptive case study on the application of systems engineering and systems engineering management at Armscor. The report also covers the investigation into development methods used and the how the requirements changes...

Neutrons and synchrotron radiation in engineering materials science from fundamentals to applications

CERN Document Server

Schreyer, Andreas; Clemens, Helmut; Mayer, Svea

2017-01-01

Retaining its proven concept, the second edition of this ready reference specifically addresses the need of materials engineers for reliable, detailed information on modern material characterization methods. As such, it provides a systematic overview of the increasingly important field of characterization of engineering materials with the help of neutrons and synchrotron radiation. The first part introduces readers to the fundamentals of structure-property relationships in materials and the radiation sources suitable for materials characterization. The second part then focuses on such characterization techniques as diffraction and scattering methods, as well as direct imaging and tomography. The third part presents new and emerging methods of materials characterization in the field of 3D characterization techniques like three-dimensional X-ray diffraction microscopy. The fourth and final part is a collection of examples that demonstrate the application of the methods introduced in the first parts to probl...

Covalent and non-covalent chemical engineering of actin for biotechnological applications.

Science.gov (United States)

Kumar, Saroj; Mansson, Alf

2017-11-15

The cytoskeletal filaments are self-assembled protein polymers with 8-25nm diameters and up to several tens of micrometres length. They have a range of pivotal roles in eukaryotic cells, including transportation of intracellular cargoes (primarily microtubules with dynein and kinesin motors) and cell motility (primarily actin and myosin) where muscle contraction is one example. For two decades, the cytoskeletal filaments and their associated motor systems have been explored for nanotechnological applications including miniaturized sensor systems and lab-on-a-chip devices. Several developments have also revolved around possible exploitation of the filaments alone without their motor partners. Efforts to use the cytoskeletal filaments for applications often require chemical or genetic engineering of the filaments such as specific conjugation with fluorophores, antibodies, oligonucleotides or various macromolecular complexes e.g. nanoparticles. Similar conjugation methods are also instrumental for a range of fundamental biophysical studies. Here we review methods for non-covalent and covalent chemical modifications of actin filaments with focus on critical advantages and challenges of different methods as well as critical steps in the conjugation procedures. We also review potential uses of the engineered actin filaments in nanotechnological applications and in some key fundamental studies of actin and myosin function. Finally, we consider possible future lines of investigation that may be addressed by applying chemical conjugation of actin in new ways. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Recent Advances in Application of Biosensors in Tissue Engineering

Science.gov (United States)

Paul, Arghya; Lee, Yong-kyu; Jaffa, Ayad A.

2014-01-01

Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications. PMID:25165697

Recent Advances in Application of Biosensors in Tissue Engineering

Directory of Open Access Journals (Sweden)

Anwarul Hasan

2014-01-01

Full Text Available Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.

An Approach to Developing Independent Learning and Non-Technical Skills Amongst Final Year Mining Engineering Students

Science.gov (United States)

Knobbs, C. G.; Grayson, D. J.

2012-01-01

There is mounting evidence to show that engineers need more than technical skills to succeed in industry. This paper describes a curriculum innovation in which so-called "soft" skills, specifically inter-personal and intra-personal skills, were integrated into a final year mining engineering course. The instructional approach was…

Applications of Statistics and Probability in Civil Engineering

DEFF Research Database (Denmark)

Faber, Michael Havbro

contains the proceedings of the 11th International Conference on Applications of Statistics and Probability in Civil Engineering (ICASP11, Zürich, Switzerland, 1-4 August 2011). The book focuses not only on the more traditional technical issues, but also emphasizes the societal context...... and reliability in engineering; to professionals and engineers, including insurance and consulting companies working with natural hazards, design, operation and maintenance of civil engineering and industrial facilities; and to decision makers and professionals in the public sector, including nongovernmental...

Final Report on the Audit of Architect-Engineer Contracting at the Officer in Charge of Construction, Naval Facilities Engineering Command Contracts, Mediterranean, Madrid, Spain

Science.gov (United States)

1990-11-30

This is our final report on the audit of Architect-Engineer Contracting for the Officer in Charge of Construction, Naval Facilities Engineering...Command Contracts, Mediterranean, for your information and use. This is the fourth in a series of reports issued as part of the audit of architect-engineer...A-E) contracting. The Contract Management Directorate made the audit from August 1989 through July 1990. When we expanded the audit scope to include

Engineered Proteins: Redox Properties and Their Applications

Science.gov (United States)

Prabhulkar, Shradha; Tian, Hui; Wang, Xiaotang; Zhu, Jun-Jie

2012-01-01

Abstract Oxidoreductases and metalloproteins, representing more than one third of all known proteins, serve as significant catalysts for numerous biological processes that involve electron transfers such as photosynthesis, respiration, metabolism, and molecular signaling. The functional properties of the oxidoreductases/metalloproteins are determined by the nature of their redox centers. Protein engineering is a powerful approach that is used to incorporate biological and abiological redox cofactors as well as novel enzymes and redox proteins with predictable structures and desirable functions for important biological and chemical applications. The methods of protein engineering, mainly rational design, directed evolution, protein surface modifications, and domain shuffling, have allowed the creation and study of a number of redox proteins. This review presents a selection of engineered redox proteins achieved through these methods, resulting in a manipulation in redox potentials, an increase in electron-transfer efficiency, and an expansion of native proteins by de novo design. Such engineered/modified redox proteins with desired properties have led to a broad spectrum of practical applications, ranging from biosensors, biofuel cells, to pharmaceuticals and hybrid catalysis. Glucose biosensors are one of the most successful products in enzyme electrochemistry, with reconstituted glucose oxidase achieving effective electrical communication with the sensor electrode; direct electron-transfer-type biofuel cells are developed to avoid thermodynamic loss and mediator leakage; and fusion proteins of P450s and redox partners make the biocatalytic generation of drug metabolites possible. In summary, this review includes the properties and applications of the engineered redox proteins as well as their significance and great potential in the exploration of bioelectrochemical sensing devices. Antioxid. Redox Signal. 17, 1796–1822. PMID:22435347

Microwave RF antennas and circuits nonlinearity applications in engineering

CERN Document Server

Aluf, Ofer

2017-01-01

This book describes a new concept for analyzing RF/microwave circuits, which includes RF/microwave antennas. The book is unique in its emphasis on practical and innovative microwave RF engineering applications. The analysis is based on nonlinear dynamics and chaos models and shows comprehensive benefits and results. All conceptual RF microwave circuits and antennas are innovative and can be broadly implemented in engineering applications. Given the dynamics of RF microwave circuits and antennas, they are suitable for use in a broad range of applications. The book presents analytical methods for microwave RF antennas and circuit analysis, concrete examples, and geometric examples. The analysis is developed systematically, starting with basic differential equations and their bifurcations, and subsequently moving on to fixed point analysis, limit cycles and their bifurcations. Engineering applications include microwave RF circuits and antennas in a variety of topological structures, RFID ICs and antennas, micros...

An engineering method to estimate the junction temperatures of light-emitting diodes in multiple LED application

International Nuclear Information System (INIS)

Fu, Xing; Hu, Run; Luo, Xiaobing

2014-01-01

Acquiring the junction temperature of light emitting diode (LED) is essential for performance evaluation. But it is hard to get in the multiple LED applications. In this paper, an engineering method is presented to estimate the junction temperatures of LEDs in multiple LED applications. This method is mainly based on an analytical model, and it can be easily applied with some simple measurements. Simulations and experiments were conducted to prove the feasibility of the method, and the deviations among the results obtained by the present method with those by simulation as well as experiments are less than 2% and 3%, respectively. In the final part of this study, the engineering method was used to analyze the thermal resistances of a street lamp. The material of lead frame was found to affect the system thermal resistance mostly, and the choice of solder material strongly depended on the material of the lead frame.

NTRCI Legacy Engine Research and Development Project Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Smith-Holbert, Connie [National Transportation Research Center, Inc., Knoxville, TN (United States); Petrolino, Joseph [National Transportation Research Center, Inc., Knoxville, TN (United States); Watkins, Bart [Power Source Technologies Inc., Corvallis, OR (United States); Irick, David [Power Source Technologies Inc., Corvallis, OR (United States)

2011-12-31

The Legacy engine is a completely new design, transitional diesel engine, replacing the reciprocating engine with a rotary engine. The Legacy engine offers significant advances over conventional internal combustion engines in 1) power to weight ratio; 2) multiple fuel acceptance; 3) fuel economy; and 4) environmental compliance. These advances are achieved through a combination of innovative design geometry, rotary motion, aspiration simplicity, and manufacturing/part simplicity. The key technical challenge to the Legacy engine's commercialization, and the focus of this project, was the development of a viable roton tip seal. The PST concept for the roton tip seal was developed into a manufacturable design. The design was evaluated using a custom designed and fabricated seal test fixture and further refined. This design was incorporated into the GEN2.5A prototype and tested for achievable compression pressure. The Decision Point at the end of Phase 1 of the project (described below) was to further optimize the existing tip seal design. Enhancements to the tip seal design were incorporated into the GEN2.5B prototype and tested and evaluated using the iterative research strategy described below. Compression pressures adequate for compression ignition of diesel fuel were achieved, although not consistently in all combustion volumes. The variation in compression pressures was characterized versus design features. As the roton tip seal performance was improved, results pointed toward inadequate performance of the housing side seals. Enhancement of the housing side seal system was accomplished using a custom designed side seal test fixture. The design enhancements developed with the test fixture were also incorporated into the GEN2.5B prototype and tested and evaluated using the iterative research strategy described below. Finally, to simplify the requirements for the roton tip seals and to enhance the introduction and combustion of fuel, a flush-mount fuel injector

International Conference on Soft Computing Techniques and Engineering Application

CERN Document Server

Li, Xiaolong

2014-01-01

The main objective of ICSCTEA 2013 is to provide a platform for researchers, engineers and academicians from all over the world to present their research results and development activities in soft computing techniques and engineering application. This conference provides opportunities for them to exchange new ideas and application experiences face to face, to establish business or research relations and to find global partners for future collaboration.

Demonstration of diesel fired coolant heaters in school bus applications : final report.

Science.gov (United States)

2010-04-01

Engine block pre-heating can reduce fuel consumption, decrease pollution, extend engine life, and it is often necessary for reliably starting diesel engines in cold climates. This report describes the application and experience of applying 36 diesel ...

Preparation of Laponite Bioceramics for Potential Bone Tissue Engineering Applications

Science.gov (United States)

Li, Kai; Ju, Yaping; Li, Jipeng; Zhang, Yongxing; Li, Jinhua; Liu, Xuanyong; Shi, Xiangyang; Zhao, Qinghua

2014-01-01

We report a facile approach to preparing laponite (LAP) bioceramics via sintering LAP powder compacts for bone tissue engineering applications. The sintering behavior and mechanical properties of LAP compacts under different temperatures, heating rates, and soaking times were investigated. We show that LAP bioceramic with a smooth and porous surface can be formed at 800°C with a heating rate of 5°C/h for 6 h under air. The formed LAP bioceramic was systematically characterized via different methods. Our results reveal that the LAP bioceramic possesses an excellent surface hydrophilicity and serum absorption capacity, and good cytocompatibility and hemocompatibility as demonstrated by resazurin reduction assay of rat mesenchymal stem cells (rMSCs) and hemolytic assay of pig red blood cells, respectively. The potential bone tissue engineering applicability of LAP bioceramic was explored by studying the surface mineralization behavior via soaking in simulated body fluid (SBF), as well as the surface cellular response of rMSCs. Our results suggest that LAP bioceramic is able to induce hydroxyapatite deposition on its surface when soaked in SBF and rMSCs can proliferate well on the LAP bioceramic surface. Most strikingly, alkaline phosphatase activity together with alizarin red staining results reveal that the produced LAP bioceramic is able to induce osteoblast differentiation of rMSCs in growth medium without any inducing factors. Finally, in vivo animal implantation, acute systemic toxicity test and hematoxylin and eosin (H&E)-staining data demonstrate that the prepared LAP bioceramic displays an excellent biosafety and is able to heal the bone defect. Findings from this study suggest that the developed LAP bioceramic holds a great promise for treating bone defects in bone tissue engineering. PMID:24955961

Radioactivity source terms for underground engineering application

Energy Technology Data Exchange (ETDEWEB)

Tewes, H A [Lawrence Radiation Laboratory, Livermore, CA (United States)

1969-07-01

The constraints on nuclide production are usually very similar in any underground engineering application of nuclear explosives. However, in some applications the end product could be contaminated unless the proper nuclear device is used. This fact can be illustrated from two underground engineering experiments-Gasbuggy and Sloop. In the Gasbuggy experiment, appreciable tritium has been shown to be present in the gas currently being produced. However, in future gas stimulation applications (as distinct from experiments), a minimum production of tritium by the explosive is desirable since product contamination by this nuclide may place severe limitations on the use of the tritiated gas. In Sloop, where production of copper is the goal of the experiment, product contamination would not be caused by tritium but could result from other nuclides: Thus, gas stimulation could require the use of fission explosives while the lower cost per kiloton of thermonuclear explosives could make them attractive for ore-crushing applications. Because of this consideration, radionuclide production calculations must be made for both fission and for thermonuclear explosives in the underground environment. Such activation calculations materials of construction are performed in a manner similar to that described in another paper, but radionuclide production in the environment must be computed using both fission neutron and 14-MeV neutron sources in order to treat the 'source term' problem realistically. In making such computations, parameter studies including the effects of environmental temperature, neutron shielding, and rock types have been carried out. Results indicate the importance of carefully evaluating the radionuclide production for each individual underground engineering application. (author)

Radioactivity source terms for underground engineering application

International Nuclear Information System (INIS)

Tewes, H.A.

1969-01-01

The constraints on nuclide production are usually very similar in any underground engineering application of nuclear explosives. However, in some applications the end product could be contaminated unless the proper nuclear device is used. This fact can be illustrated from two underground engineering experiments-Gasbuggy and Sloop. In the Gasbuggy experiment, appreciable tritium has been shown to be present in the gas currently being produced. However, in future gas stimulation applications (as distinct from experiments), a minimum production of tritium by the explosive is desirable since product contamination by this nuclide may place severe limitations on the use of the tritiated gas. In Sloop, where production of copper is the goal of the experiment, product contamination would not be caused by tritium but could result from other nuclides: Thus, gas stimulation could require the use of fission explosives while the lower cost per kiloton of thermonuclear explosives could make them attractive for ore-crushing applications. Because of this consideration, radionuclide production calculations must be made for both fission and for thermonuclear explosives in the underground environment. Such activation calculations materials of construction are performed in a manner similar to that described in another paper, but radionuclide production in the environment must be computed using both fission neutron and 14-MeV neutron sources in order to treat the 'source term' problem realistically. In making such computations, parameter studies including the effects of environmental temperature, neutron shielding, and rock types have been carried out. Results indicate the importance of carefully evaluating the radionuclide production for each individual underground engineering application. (author)

Stirling engine alternatives for the terrestrial solar application

Science.gov (United States)

Stearns, J.

1985-01-01

The first phase of the present study of Stirling engine alternatives for solar thermal-electric generation has been completed. Development risk levels are considered to be high for all engines evaluated. Free-piston type and Ringbom-type Stirling engine-alternators are not yet developed for the 25 to 50-kW electrical power range, although smaller machines have demonstrated the inherent robustness of the machines. Kinematic-type Stirling engines are presently achieving a 3500 hr lifetime or longer on critical components, and lifetime must still be further extended for the solar application. Operational and technical characteristics of all types of Stirling engines have been reviewed with engine developers. Technical work of merit in progress in each engine development organization should be recognized and supported in an appropriate manner.

Introduction to Plasma Technology Science, Engineering and Applications

CERN Document Server

Harry, John Ernest

2011-01-01

Written by a university lecturer with more than forty years experience in plasma technology, this book adopts a didactic approach in its coverage of the theory, engineering and applications of technological plasmas. The theory is developed in a unified way to enable brevity and clarity, providing readers with the necessary background to assess the factors that affect the behavior of plasmas under different operating conditions. The major part of the book is devoted to the applications of plasma technology and their accompanying engineering aspects, classified by the various pressure and densit

Ramgen Power Systems-Supersonic Component Technology for Military Engine Applications

National Research Council Canada - National Science Library

Sohn, Chang W; Holcomb, Franklin H; Baldwin, Peter; Lawlor, Shawn; Steele, Robert C; Belshaw, Karen; Tamm, Gunnar

2006-01-01

...) a unique configuration that minimizes flow stream turning losses throughout the engine. The RPS engine concept can be configured as a high-pressure ratio simple-cycle design for propulsion applications or as a low-pressure ratio recuperated engine...

Electron microscopy for Engineers

International Nuclear Information System (INIS)

Jones, I P

2009-01-01

This paper reviews the application of (mainly) Transmission Electron Microscopy (TEM) in an engineering context. The first two sections are TEM and chemical in nature; the final three sections are more general and include aspects of Scanning Electron Microscopy (SEM).

Different methods of dentin processing for application in bone tissue engineering: A systematic review.

Science.gov (United States)

Tabatabaei, Fahimeh Sadat; Tatari, Saeed; Samadi, Ramin; Moharamzadeh, Keyvan

2016-10-01

Dentin has become an interesting potential biomaterial for tissue engineering of oral hard tissues. It can be used as a scaffold or as a source of growth factors in bone tissue engineering. Different forms of dentin have been studied for their potential use as bone substitutes. Here, we systematically review different methods of dentin preparation and the efficacy of processed dentin in bone tissue engineering. An electronic search was carried out in PubMed and Scopus databases for articles published from 2000 to 2016. Studies on dentin preparation for application in bone tissue engineering were selected. The initial search yielded a total of 1045 articles, of which 37 were finally selected. Review of studies showed that demineralization was the most commonly used dentin preparation process for use in tissue engineering. Dentin extract, dentin particles (tooth ash), freeze-dried dentin, and denatured dentin are others method of dentin preparation. Based on our literature review, we can conclude that preparation procedure and the size and shape of dentin particles play an important role in its osteoinductive and osteoconductive properties. Standardization of these methods is important to draw a conclusion in this regard. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2616-2627, 2016. © 2016 Wiley Periodicals, Inc.

Design and rapid prototyping of DLC coated fractal surfaces for tissue engineering applications

International Nuclear Information System (INIS)

Diaz-Lantada, A; Mosquera, A; Endrino, J L; Lafont, P

2010-01-01

Several medical devices (both implantable and for in vitro diagnosis) benefit greatly from having microtextured surfaces that help to improve and promote phenomena such as osteointegracion and cell / tissue growth on the surface of a device. Normally, the use of abrasives or chemical attacks are employed for obtaining such surface microtextures, however, it is sometimes difficult to precisely control the final surface characteristics (porosity, roughness, among others) and consequently the related biological aspects. In this work, we propose an alternative process based on the use of fractal surface models for designing special surfaces, which helps controlling the desired contact properties (from the design stage) in multiple applications within biomedical engineering, especially regarding tissue engineering tasks. Manufacturing can be directly accomplished by means of rapid prototyping technologies. This method supposes a focus change from a conventional 'top-down' to a more versatile 'bottom-up' approach. Finally, in order to improve the possible biological response, the surfaces of the designed devices were coated with hydrogen-free amorphous carbon (a-C) thin films, known to be highly biocompatible materials. The films were deposited at room temperature using the vacuum filter cathodic arc technique. Our first prototypes have helped verify the viability of the approach and to validate the design, manufacturing and coating processes.

Design and rapid prototyping of DLC coated fractal surfaces for tissue engineering applications

Energy Technology Data Exchange (ETDEWEB)

Diaz-Lantada, A; Mosquera, A; Endrino, J L; Lafont, P, E-mail: adiaz@etsii.upm.es

2010-11-01

Several medical devices (both implantable and for in vitro diagnosis) benefit greatly from having microtextured surfaces that help to improve and promote phenomena such as osteointegracion and cell / tissue growth on the surface of a device. Normally, the use of abrasives or chemical attacks are employed for obtaining such surface microtextures, however, it is sometimes difficult to precisely control the final surface characteristics (porosity, roughness, among others) and consequently the related biological aspects. In this work, we propose an alternative process based on the use of fractal surface models for designing special surfaces, which helps controlling the desired contact properties (from the design stage) in multiple applications within biomedical engineering, especially regarding tissue engineering tasks. Manufacturing can be directly accomplished by means of rapid prototyping technologies. This method supposes a focus change from a conventional 'top-down' to a more versatile 'bottom-up' approach. Finally, in order to improve the possible biological response, the surfaces of the designed devices were coated with hydrogen-free amorphous carbon (a-C) thin films, known to be highly biocompatible materials. The films were deposited at room temperature using the vacuum filter cathodic arc technique. Our first prototypes have helped verify the viability of the approach and to validate the design, manufacturing and coating processes.

An integrator final exam at the end of the engineering degrees to evaluate the acquired competences

Science.gov (United States)

Perdigones, A.; Sánchez, E.; Valiño, V.; Tarquis, A. M.

2010-05-01

In the last decade strong changes in the design of university degrees have occurred in Spain, affecting real competences acquired by graduates. The new degrees often provide students greater freedom in shaping their curriculum which results in many cases in a problem for their training. In engineering degrees of Spain, the final project, that allows to know the integrated skills of the students in engineering subjects, is not compulsory anymore; it can be substituted for other specific types of work that often do not involve skills valued by the companies of the industrial sector. This situation may create doubts about the real competences of the graduates. In the present study, a final exam (voluntary) has been carried out during three years to assess competences in engineering students in the last course of the degree in agricultural engineering (diploma of five years) and agricultural technical engineering (diploma of three years) at the Polytechnic University of Madrid (Spain). They took part 132 students in the years 2006, 2007 and 2008. The exam had a common format, with three parts assessing skills in construction, machinery and electrical installations. The results showed the evolution in the training of students, and the relationship between skills acquired and late differences in the learning process. The most important conclusions were that the attainment levels was lower than expected, but generally consistent with the training received by each group of students. In particular, the low number of hours of subjects in electrical installations in certain groups of students was evident when evaluating the skills acquired. The results indicated that they aim to increase the number of hours in certain subjects and groups of students, if a graduate is to get qualified. The authors recommend an examination similar to the raised, integrator type, in all programs that do not have any overall final assessment in order to conduct a quality control of graduates

Application of L.D.A. to measure instantaneous flow velocity field in the exhaust of a combustion engine

International Nuclear Information System (INIS)

Boutrif, M.S.; Thelliez, M.

1993-01-01

We present experimental results of instantaneous velocity measurement, which were obtained by application of the laser Doppler anemometry (L.D.A.) at the exhaust pipe of a reciprocating engine under real working conditions. First of all, we show that the instantaneous velocity is monodimensional along a straight exhaust pipe, and that the boundary layer develops within a 2 mm thickness. We also show that the cylinder discharges in two phases: the blow down period and the final part of exhaust stroke. We also make obvious, that the flow escapes very quickly: its velocity varies betwen -100 m/s and 200 m/s within a period shorter than 1 ms; thereby, we do record the acoustic resonance phenomenon, when the engine speed is greater than 3 000 rpm. Finally, we show that in the exhaust pipe the apparent fluctuation - i.e. the cyclic dispersion and the actual turbulence - may reach 15%. (orig.)

3D-Printed Biopolymers for Tissue Engineering Application

Directory of Open Access Journals (Sweden)

Xiaoming Li

2014-01-01

Full Text Available 3D printing technology has recently gained substantial interest for potential applications in tissue engineering due to the ability of making a three-dimensional object of virtually any shape from a digital model. 3D-printed biopolymers, which combine the 3D printing technology and biopolymers, have shown great potential in tissue engineering applications and are receiving significant attention, which has resulted in the development of numerous research programs regarding the material systems which are available for 3D printing. This review focuses on recent advances in the development of biopolymer materials, including natural biopolymer-based materials and synthetic biopolymer-based materials prepared using 3D printing technology, and some future challenges and applications of this technology are discussed.

The development and testing of ceramic components in piston engines. Final report

Energy Technology Data Exchange (ETDEWEB)

McEntire, B.J. [Norton Co., Northboro, MA (United States). Advanced Ceramics Div.; Willis, R.W.; Southam, R.E. [TRW, Inc., Cleveland, OH (United States)

1994-10-01

Within the past 10--15 years, ceramic hardware has been fabricated and tested in a number of piston engine applications including valves, piston pins, roller followers, tappet shims, and other wear components. It has been shown that, with proper design and installation, ceramics improve performance, fuel economy, and wear and corrosion resistance. These results have been obtained using rig and road tests on both stock and race engines. Selected summaries of these tests are presented in this review paper.

Android Application Protection against Static Reverse Engineering based on Multidexing

Directory of Open Access Journals (Sweden)

Nak Young Kim

2016-11-01

Full Text Available DEX files are executable files of Android applications. Since DEX files are in the format of Java bytecodes, their Java source codes can be easily obtained using static reverse engineering tools. This results in numerous Android application thefts. There are some tools (e.g. bangcle, ijiami, liapp that protect Android applications against static reverse engineering utilizing dynamic code loading. These tools usually encrypt classes.dex in an APK file. When the application is launched, the encrypted classes.dex file is decrypted and dynamically loaded. However, these tools fail to protect multidex APKs, which include more than one DEX files (classes2.dex, classes3.dex, ... to accommodate large-sized execution codes. In this paper, we propose a technique that protects multidex Android applications against static reverse engineering. The technique can encrypt/decrypt multiple DEX files in APK files and dynamically load them. The experimental results show that the proposed technique can effiectively protect multidex APKs.

Engineering Evaluation/Cost Analysis for Power Burst Facility (PER-620) Final End State and PBF Vessel Disposal

Energy Technology Data Exchange (ETDEWEB)

B. C. Culp

2007-05-01

Preparation of this engineering evaluation/cost analysis is consistent with the joint U.S. Department of Energy and U.S. Environmental Protection Agency Policy on Decommissioning of Department of Energy Facilities Under the Comprehensive Environmental Response, Compensation, and Liability Act, (DOE and EPA 1995) which establishes the Comprehensive Environmental, Response, Compensation, and Liability Act non-time critical removal action process as an approach for decommissioning. The scope of this engineering evaluation/cost analysis is to evaluate alternatives and recommend a preferred alternative for the final end state of the PBF and the final disposal location for the PBF vessel.

Teaching learning based optimization algorithm and its engineering applications

CERN Document Server

Rao, R Venkata

2016-01-01

Describing a new optimization algorithm, the “Teaching-Learning-Based Optimization (TLBO),” in a clear and lucid style, this book maximizes reader insights into how the TLBO algorithm can be used to solve continuous and discrete optimization problems involving single or multiple objectives. As the algorithm operates on the principle of teaching and learning, where teachers influence the quality of learners’ results, the elitist version of TLBO algorithm (ETLBO) is described along with applications of the TLBO algorithm in the fields of electrical engineering, mechanical design, thermal engineering, manufacturing engineering, civil engineering, structural engineering, computer engineering, electronics engineering, physics and biotechnology. The book offers a valuable resource for scientists, engineers and practitioners involved in the development and usage of advanced optimization algorithms.

Engineering mechanical microenvironment of macrophage and its biomedical applications.

Science.gov (United States)

Li, Jing; Li, Yuhui; Gao, Bin; Qin, Chuanguang; He, Yining; Xu, Feng; Yang, Hui; Lin, Min

2018-03-01

Macrophages are the most plastic cells in the hematopoietic system and can be widely found in almost all tissues. Recently studies have shown that mechanical cues (e.g., matrix stiffness and stress/strain) can significantly affect macrophage behaviors. Although existing reviews on the physical and mechanical cues that regulate the macrophage's phenotype are available, engineering mechanical microenvironment of macrophages in vitro as well as a comprehensive overview and prospects for their biomedical applications (e.g., tissue engineering and immunotherapy) has yet to be summarized. Thus, this review provides an overview on the existing methods for engineering mechanical microenvironment of macrophages in vitro and then a section on their biomedical applications and further perspectives are presented.

Fast radial basis functions for engineering applications

CERN Document Server

Biancolini, Marco Evangelos

2017-01-01

This book presents the first “How To” guide to the use of radial basis functions (RBF). It provides a clear vision of their potential, an overview of ready-for-use computational tools and precise guidelines to implement new engineering applications of RBF. Radial basis functions (RBF) are a mathematical tool mature enough for useful engineering applications. Their mathematical foundation is well established and the tool has proven to be effective in many fields, as the mathematical framework can be adapted in several ways. A candidate application can be faced considering the features of RBF:  multidimensional space (including 2D and 3D), numerous radial functions available, global and compact support, interpolation/regression. This great flexibility makes RBF attractive – and their great potential has only been partially discovered. This is because of the difficulty in taking a first step toward RBF as they are not commonly part of engineers’ cultural background, but also due to the numerical complex...

Building information modelling review with potential applications in tunnel engineering of China

Science.gov (United States)

Zhou, Weihong; Qin, Haiyang; Qiu, Junling; Fan, Haobo; Lai, Jinxing; Wang, Ke; Wang, Lixin

2017-08-01

Building information modelling (BIM) can be applied to tunnel engineering to address a number of problems, including complex structure, extensive design, long construction cycle and increased security risks. To promote the development of tunnel engineering in China, this paper combines actual cases, including the Xingu mountain tunnel and the Shigu Mountain tunnel, to systematically analyse BIM applications in tunnel engineering in China. The results indicate that BIM technology in tunnel engineering is currently mainly applied during the design stage rather than during construction and operation stages. The application of BIM technology in tunnel engineering covers many problems, such as a lack of standards, incompatibility of different software, disorganized management, complex combination with GIS (Geographic Information System), low utilization rate and poor awareness. In this study, through summary of related research results and engineering cases, suggestions are introduced and an outlook for the BIM application in tunnel engineering in China is presented, which provides guidance for design optimization, construction standards and later operation maintenance.

English Language Writing Anxiety among Final Year Engineering Undergraduates in University Putra Malaysia

Science.gov (United States)

Min, Lau Sing; Rahmat, Nurhazlini

2014-01-01

Second Language Writing Anxiety (SLWA) is considered one of the most crucial factors affecting all second language learning. This study focused on a group of final year Engineering students' English Language writing anxiety (N = 93) in relation to their gender, race and MUET results. The findings showed that the male gender, Chinese and MUET band…

The Application of Tissue Engineering Procedures to Repair the Larynx

Science.gov (United States)

Ringel, Robert L.; Kahane, Joel C.; Hillsamer, Peter J.; Lee, Annie S.; Badylak, Stephen F.

2006-01-01

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

Micro-/nano-engineered cellular responses for soft tissue engineering and biomedical applications.

Science.gov (United States)

Tay, Chor Yong; Irvine, Scott Alexander; Boey, Freddy Y C; Tan, Lay Poh; Venkatraman, Subbu

2011-05-23

The development of biomedical devices and reconstruction of functional ex vivo tissues often requires the need to fabricate biomimetic surfaces with features of sub-micrometer precision. This can be achieved with the advancements in micro-/nano-engineering techniques, allowing researchers to manipulate a plethora of cellular behaviors at the cell-biomaterial interface. Systematic studies conducted on these 2D engineered surfaces have unraveled numerous novel findings that can potentially be integrated as part of the design consideration for future 2D and 3D biomaterials and will no doubt greatly benefit tissue engineering. In this review, recent developments detailing the use of micro-/nano-engineering techniques to direct cellular orientation and function pertinent to soft tissue engineering will be highlighted. Particularly, this article aims to provide valuable insights into distinctive cell interactions and reactions to controlled surfaces, which can be exploited to understand the mechanisms of cell growth on micro-/nano-engineered interfaces, and to harness this knowledge to optimize the performance of 3D artificial soft tissue grafts and biomedical applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Optimized application of systems engineering to nuclear waste repository projects

International Nuclear Information System (INIS)

Miskimin, P.A.; Shepard, M.

1986-01-01

The purpose of this presentation is to describe a fully optimized application of systems engineering methods and philosophy to the management of a large nuclear waste repository project. Knowledge gained from actual experience with the use of the systems approach on two repository projects is incorporated in the material presented. The projects are currently evaluating the isolation performance of different geologic settings and are in different phases of maturity. Systems engineering methods were applied by the principal author at the Waste Isolation Pilot Plant (WIPP) in the form of a functional analysis. At the Basalt Waste Isolation Project (BWIP), the authors assisted the intergrating contractor with the development and application of systems engineering methods. Based on this experience and that acquired from other waste management projects, an optimized plan for applying systems engineering techniques was developed. The plan encompasses the following aspects: project organization, developing and defining requirements, assigning work responsibilities, evaluating system performance, quality assurance, controlling changes, enhancing licensability, optimizing project performance, and addressing regulatory issues. This information is presented in the form of a roadmap for the practical application of system engineering principles to a nuclear waste repository project

System Engineering of Photonic Systems for Space Application

Science.gov (United States)

Watson, Michael D.; Pryor, Jonathan E.

2014-01-01

The application of photonics in space systems requires tight integration with the spacecraft systems to ensure accurate operation. This requires some detailed and specific system engineering to properly incorporate the photonics into the spacecraft architecture and to guide the spacecraft architecture in supporting the photonics devices. Recent research in product focused, elegant system engineering has led to a system approach which provides a robust approach to this integration. Focusing on the mission application and the integration of the spacecraft system physics incorporation of the photonics can be efficiently and effectively accomplished. This requires a clear understanding of the driving physics properties of the photonics device to ensure proper integration with no unintended consequences. The driving physics considerations in terms of optical performance will be identified for their use in system integration. Keywords: System Engineering, Optical Transfer Function, Optical Physics, Photonics, Image Jitter, Launch Vehicle, System Integration, Organizational Interaction

Modern mechanical engineering research, development and education

CERN Document Server

2014-01-01

This book covers modern subjects of mechanical engineering such as nanomechanics and nanotechnology, mechatronics and robotics, computational mechanics, biomechanics, alternative energies, sustainability as well as all aspects related with mechanical engineering education. The chapters help enhance the understanding of both the fundamentals of mechanical engineering and its application to the solution of problems in modern industry. This book is suitable for students, both in final undergraduate mechanical engineering courses or at the graduate level. It also serves as a useful reference for academics, mechanical engineering researchers, mechanical, materials and manufacturing engineers, professionals in related with mechanical engineering.

The history and evolution of optically accessible research engines and their impact on our understanding of engine combustion

Energy Technology Data Exchange (ETDEWEB)

Miles, Paul C. [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

2015-03-01

The development and application of optically accessible engines to further our understanding of in-cylinder combustion processes is reviewed, spanning early efforts in simplified engines to the more recent development of high-pressure, high-speed engines that retain the geometric complexities of modern production engines. Limitations of these engines with respect to the reproduction of realistic metal test engine characteristics and performance are identified, as well as methods that have been used to overcome these limitations. Finally, the role of the work performed in these engines on clarifying the fundamental physical processes governing the combustion process and on laying the foundation for predictive engine simulation is summarized.

Fuzzy Sets Applications in Civil Engineering Basic Areas

Directory of Open Access Journals (Sweden)

Latif Onur UĞUR

2016-01-01

Full Text Available Civil engineering is a professional engineering discipline that deals with the design, construction, and maintenance of the physical and naturally built environment, including works like roads, bridges, canals, dams, and buildings. This paper presents some Fuzzy Logic (FL applications in civil engeering discipline and shows the potential of facilities of FL in this area. The potential role of fuzzy sets in analysing system and human uncertainty is investigated in the paper. The main finding of this inquiry is FL applications used in different areas of civil engeering discipline with success. Once developed, the fuzzy logic models can be used for further monitoring activities, as a management tool.

GLobal Integrated Design Environment (GLIDE): A Concurrent Engineering Application

Science.gov (United States)

McGuire, Melissa L.; Kunkel, Matthew R.; Smith, David A.

2010-01-01

The GLobal Integrated Design Environment (GLIDE) is a client-server software application purpose-built to mitigate issues associated with real time data sharing in concurrent engineering environments and to facilitate discipline-to-discipline interaction between multiple engineers and researchers. GLIDE is implemented in multiple programming languages utilizing standardized web protocols to enable secure parameter data sharing between engineers and researchers across the Internet in closed and/or widely distributed working environments. A well defined, HyperText Transfer Protocol (HTTP) based Application Programming Interface (API) to the GLIDE client/server environment enables users to interact with GLIDE, and each other, within common and familiar tools. One such common tool, Microsoft Excel (Microsoft Corporation), paired with its add-in API for GLIDE, is discussed in this paper. The top-level examples given demonstrate how this interface improves the efficiency of the design process of a concurrent engineering study while reducing potential errors associated with manually sharing information between study participants.

Fundamentals of reliability engineering applications in multistage interconnection networks

CERN Document Server

Gunawan, Indra

2014-01-01

This book presents fundamentals of reliability engineering with its applications in evaluating reliability of multistage interconnection networks. In the first part of the book, it introduces the concept of reliability engineering, elements of probability theory, probability distributions, availability and data analysis.  The second part of the book provides an overview of parallel/distributed computing, network design considerations, and more.  The book covers a comprehensive reliability engineering methods and its practical aspects in the interconnection network systems. Students, engineers, researchers, managers will find this book as a valuable reference source.

ESPACE - a geodetic Master's program for the education of Satellite Application Engineers

Science.gov (United States)

Hedman, K.; Kirschner, S.; Seitz, F.

2012-04-01

In the last decades there has been a rapid development of new geodetic and other Earth observation satellites. Applications of these satellites such as car navigation systems, weather predictions, and, digital maps (such as Google Earth or Google Maps) play a more and more important role in our daily life. For geosciences, satellite applications such as remote sensing and precise positioning/navigation have turned out to be extremely useful and are meanwhile indispensable. Today, researchers within geodesy, climatology, oceanography, meteorology as well as within Earth system science are all dependent on up-to-date satellite data. Design, development and handling of these missions require experts with knowledge not only in space engineering, but also in the specific applications. That gives rise to a new kind of engineers - satellite application engineers. The study program for these engineers combines parts of different classical disciplines such as geodesy, aerospace engineering or electronic engineering. The satellite application engineering program Earth Oriented Space Science and Technology (ESPACE) was founded in 2005 at the Technische Universität München, mainly from institutions involved in geodesy and aerospace engineering. It is an international, interdisciplinary Master's program, and is open to students with a BSc in both Science (e.g. Geodesy, Mathematics, Informatics, Geophysics) and Engineering (e.g. Aerospace, Electronical and Mechanical Engineering). The program is completely conducted in English. ESPACE benefits from and utilizes its location in Munich with its unique concentration of expertise related to space science and technology. Teaching staff from 3 universities (Technische Universität München, Ludwig-Maximilian University, University of the Federal Armed Forces), research institutions (such as the German Aerospace Center, DLR and the German Geodetic Research Institute, DGFI) and space industry (such as EADS or Kayser-Threde) are

Engineered cell manipulation for biomedical application

CERN Document Server

Akashi, Misturu; Matsusaki, Michiya

2014-01-01

This book is the first to summarize new technologies for engineered cell manipulation. The contents focus on control of cellular functions by nanomaterials and control of three-dimensional cell-cell interactions. Control of cellular functions is important for cell differentiation, maturation, and activation, which generally are controlled by the addition of soluble cytokines or growth factors into cell culture dishes. Target antigen molecules can be efficiently delivered to the cytosol of the dendritic cells using the nanoparticle technique described here, and cellular functions such as dendritic cell maturation can be controlled easily and with precision. This book describes basic preparation of the nanoparticles, activation control of dendritic cells, immune function control, and in vivo application for various vaccination systems. The second type of control,that of cell-cell interaction, is important for tissue engineering in order to develop three-dimensional cellular constructs. To achieve in vitro engin...

Ion engine auxiliary propulsion applications and integration study

Science.gov (United States)

Zafran, S. (Editor)

1977-01-01

The benefits derived from application of the 8-cm mercury electron bombardment ion thruster were assessed. Two specific spacecraft missions were studied. A thruster was tested to provide additional needed information on its efflux characteristics and interactive effects. A Users Manual was then prepared describing how to integrate the thruster for auxiliary propulsion on geosynchronous satellites. By incorporating ion engines on an advanced communications mission, the weight available for added payload increases by about 82 kg (181 lb) for a 100 kg (2200 lb) satellite which otherwise uses electrothermal hydrazine. Ion engines can be integrated into a high performance propulsion module that is compatible with the multimission modular spacecraft and can be used for both geosynchronous and low earth orbit applications. The low disturbance torques introduced by the ion engines permit accurate spacecraft pointing with the payload in operation during thrusting periods. The feasibility of using the thruster's neutralizer assembly for neutralization of differentially charged spacecraft surfaces at geosynchronous altitude was demonstrated during the testing program.

Practical applications of soft computing in engineering

CERN Document Server

2001-01-01

Soft computing has been presented not only with the theoretical developments but also with a large variety of realistic applications to consumer products and industrial systems. Application of soft computing has provided the opportunity to integrate human-like vagueness and real-life uncertainty into an otherwise hard computer program. This book highlights some of the recent developments in practical applications of soft computing in engineering problems. All the chapters have been sophisticatedly designed and revised by international experts to achieve wide but in-depth coverage. Contents: Au

Engineering growth factors for regenerative medicine applications.

Energy Technology Data Exchange (ETDEWEB)

Mitchell, Aaron C.; Briquez, Priscilla S.; Hubbell, Jeffrey A.; Cochran, Jennifer R.

2016-01-15

Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in regenerative medicine applications, translation of growth factors into clinical treatments has been hindered by limitations including poor protein stability, low recombinant expression yield, and suboptimal efficacy. This review highlights current tools, technologies, and approaches to design integrated and effective growth factor-based therapies for regenerative medicine applications. The first section describes rational and combinatorial protein engineering approaches that have been utilized to improve growth factor stability, expression yield, biodistribution, and serum half-life, or alter their cell trafficking behavior or receptor binding affinity. The second section highlights elegant biomaterial-based systems, inspired by the natural extracellular matrix milieu, that have been developed for effective spatial and temporal delivery of growth factors to cell surface receptors. Although appearing distinct, these two approaches are highly complementary and involve principles of molecular design and engineering to be considered in parallel when developing optimal materials for clinical applications.

Application of diagnostic system for diesel engine

International Nuclear Information System (INIS)

Yoshinaga, Takeshi; Hayashi, Haruji; Usui, Hiromi; Tsuruzono, Atsuya; Matsuda, Takafumi

2008-01-01

The Japan Atomic Power Company (JAPC) began to implement Condition Based Maintenance (CBM) for rotating components (pumps, fans and electric motors) from 1999 and, also has begun to apply diesel engine diagnostic techniques at our three nuclear power plants since 2004. This paper provides a description of the CBM methods used for diesel engines in nuclear standby service, a summary of the procedures to introduce these diagnostic techniques to our nuclear power plants, and experience with the application of these methods to JAPC nuclear power plants. (author)

Selected engineering properties and applications of EPS geofoam

Science.gov (United States)

Elragi, Ahmed Fouad

Expanded polystyrene (EPS) geofoam is a lightweight material that has been used in engineering applications since at least the 1950s. Its density is about a hundredth of that of soil. It has good thermal insulation properties with stiffness and compression strength comparable to medium clay. It is utilized in reducing settlement below embankments, sound and vibration damping, reducing lateral pressure on substructures, reducing stresses on rigid buried conduits and related applications. This study starts with an overview on EPS geofoam. EPS manufacturing processes are described followed by a review of engineering properties found in previous research work done so far. Standards and design manuals applicable to EPS are presented. Selected EPS geofoam-engineering applications are discussed with examples. State-of-the-art of experimental work is done on different sizes of EPS specimens under different loading rates for better understanding of the behavior of the material. The effects of creep, sample size, strain rate and cyclic loading on the stress strain response are studied. Equations for the initial modulus and the strength of the material under compression for different strain rates are presented. The initial modulus and Poisson's ratio are discussed in detail. Sample size effect on creep behavior is examined. Three EPS projects are shown in this study. The creep behavior of the largest EPS geofoam embankment fill is shown. Results from laboratory tests, mathematical modeling and field records are compared to each other. Field records of a geofoam-stabilized slope are compared to finite difference analysis results. Lateral stress reduction on an EPS backfill retaining structure is analyzed. The study ends with a discussion on two promising properties of EPS geofoam. These are the damping ability and the compressibility of this material. Finite element analysis, finite difference analysis and lab results are included in this discussion. The discussion with the

Magnetic Nanoparticles: Material Engineering and Emerging Applications in Lithography and Biomedicine

Science.gov (United States)

Bao, Yuping; Wen, Tianlong; Samia, Anna Cristina S.; Khandhar, Amit; Krishnan, Kannan M.

2015-01-01

We present an interdisciplinary overview of material engineering and emerging applications of iron oxide nanoparticles. We discuss material engineering of nanoparticles in the broadest sense, emphasizing size and shape control, large-area self-assembly, composite/hybrid structures, and surface engineering. This is followed by a discussion of several non-traditional, emerging applications of iron oxide nanoparticles, including nanoparticle lithography, magnetic particle imaging, magnetic guided drug delivery, and positive contrast agents for magnetic resonance imaging. We conclude with a succinct discussion of the pharmacokinetics pathways of iron oxide nanoparticles in the human body –– an important and required practical consideration for any in vivo biomedical application, followed by a brief outlook of the field. PMID:26586919

Application of plasma technology to nuclear engineering fields

International Nuclear Information System (INIS)

Suzuki, Masaaki; Akatsuka, Hiroshi

1996-01-01

In order to discuss about the application of the plasma technology to nuclear engineering fields, we mention two subjects, the oxygenation of metal chloride waste by oxygen plasma and the characterization of fine particles generated in the plasma process. Through the experimental results of two subjects, both of the advantage and the disadvantage of the plasma technology and their characteristics are shown and discussed. The following conclusions are obtained. The reactive plasma is effective to oxygenate the chloride wastes. The particle generation which is one of the disadvantages must not be specialized and its characteristics can be estimated. Consequently, the plasma technology should be applicable to nuclear engineering fields adopting its advantage and overcoming its disadvantage. (author)

Engineering Pseudomonas for phenazine biosynthesis, regulation, and biotechnological applications: a review.

Science.gov (United States)

Bilal, Muhammad; Guo, Shuqi; Iqbal, Hafiz M N; Hu, Hongbo; Wang, Wei; Zhang, Xuehong

2017-10-03

Pseudomonas strains are increasingly attracting considerable attention as a valuable bacterial host both for basic and applied research. It has been considered as a promising candidate to produce a variety of bioactive secondary metabolites, particularly phenazines. Apart from the biotechnological perspective, these aromatic compounds have the notable potential to inhibit plant-pathogenic fungi and thus are useful in controlling plant diseases. Nevertheless, phenazines production is quite low by the wild-type strains that necessitated its yield improvement for large-scale agricultural applications. Metabolic engineering approaches with the advent of plentiful information provided by systems-level genomic and transcriptomic analyses enabled the development of new biological agents functioning as potential cell factories for producing the desired level of value-added bioproducts. This study presents an up-to-date overview of recombinant Pseudomonas strains as the preferred choice of host organisms for the biosynthesis of natural phenazines. The biosynthetic pathway and regulatory mechanism involved in the phenazine biosynthesis are comprehensively discussed. Finally, a summary of biological functionalities and biotechnological applications of the phenazines is also provided.

Irreversible thermodynamic analysis and application for molecular heat engines

Science.gov (United States)

Lucia, Umberto; Açıkkalp, Emin

2017-09-01

Is there a link between the macroscopic approach to irreversibility and microscopic behaviour of the systems? Consumption of free energy keeps the system away from a stable equilibrium. Entropy generation results from the redistribution of energy, momentum, mass and charge. This concept represents the essence of the thermodynamic approach to irreversibility. Irreversibility is the result of the interaction between systems and their environment. The aim of this paper is to determine lost works in a molecular engine and compare results with macro (classical) heat engines. Firstly, irreversible thermodynamics are reviewed for macro and molecular cycles. Secondly, irreversible thermodynamics approaches are applied for a quantum heat engine with -1/2 spin system. Finally, lost works are determined for considered system and results show that macro and molecular heat engines obey same limitations. Moreover, a quantum thermodynamic approach is suggested in order to explain the results previously obtained from an atomic viewpoint.

Towards evolution-guided microbial engineering - tools development and applications

DEFF Research Database (Denmark)

Genee, Hans Jasper

is thedevelopment of highly robust biosensor-based synthetic selection systemsthat enable high-throughput functional interrogation of complexphenotypic libraries. Using the model organism Escherichia coli as a host, Ideploy these systems to i) perform metagenome wide sequenceindependentidentification of novel...... for microbial engineering anddemonstrates direct applications to gene discovery, protein engineering andcell factory development....

Engineering applications of discrete-time optimal control

DEFF Research Database (Denmark)

Vidal, Rene Victor Valqui; Ravn, Hans V.

1990-01-01

Many problems of design and operation of engineering systems can be formulated as optimal control problems where time has been discretisized. This is also true even if 'time' is not involved in the formulation of the problem, but rather another one-dimensional parameter. This paper gives a review...... of some well-known and new results in discrete time optimal control methods applicable to practical problem solving within engineering. Emphasis is placed on dynamic programming, the classical maximum principle and generalized versions of the maximum principle for optimal control of discrete time systems...

Advances in fractional calculus theoretical developments and applications in physics and engineering

CERN Document Server

Sabatier, J; Machado, J A Teneiro

2007-01-01

Fractional Calculus is a new growing field. Up to this point, researchers, scientists, and engineers have been reluctant to accept the fact that Fractional Calculus can be used in the analysis and design of many systems of practical interests, whereas in similar applications the traditional calculus either fails or provides poor solutionsMany engineers, scientists, and applied mathematicians are looking for books that can provide many applications of Fractional Calculus. This book will provide a partial solution to this problem. Since it covers recent applications of Fractional Calculus, it will be attractive to many engineers, scientists, and applied mathematicians.

A review of optimization techniques used in the design of fibre composite structures for civil engineering applications

International Nuclear Information System (INIS)

Awad, Ziad K.; Aravinthan, Thiru; Zhuge, Yan; Gonzalez, Felipe

2012-01-01

Highlights: → We reviewed existing optimization techniques of fibre composite structures. → Proposed an improved methodology for design optimization. → Comparison showed the MRDO is most suitable. -- Abstract: Fibre composite structures have become the most attractive candidate for civil engineering applications. Fibre reinforced plastic polymer (FRP) composite materials have been used in the rehabilitation and replacement of the old degrading traditional structures or build new structures. However, the lack of design standards for civil infrastructure limits their structural applications. The majority of the existing applications have been designed based on the research and guidelines provided by the fibre composite manufacturers or based on the designer's experience. It has been a tendency that the final structure is generally over-designed. This paper provides a review on the available studies related to the design optimization of fibre composite structures used in civil engineering such as; plate, beam, box beam, sandwich panel, bridge girder, and bridge deck. Various optimization methods are presented and compared. In addition, the importance of using the appropriate optimization technique is discussed. An improved methodology, which considering experimental testing, numerical modelling, and design constrains, is proposed in the paper for design optimization of composite structures.

Electromyography physiology engineering and noninvasive applications

CERN Document Server

Parker, Philip; John Wiley & Sons

2004-01-01

"Featuring contributions from key innovators working in the field today, Electromyography reveals the broad applications of EMG data in areas as diverse as neurology, ergonomics, exercise physiology, rehabilitation, movement analysis, biofeedback, and myoelectric control of prostheses." "Electromyography offers physiologists, medical professionals, and students in biomedical engineering a new window into the possibilities of this technology."--Jacket.

Application of engineering surveying in engineering industry

Directory of Open Access Journals (Sweden)

Lucia Forgáčová

2005-11-01

Full Text Available This is a presentation of the application of surveying principles used in a process of building the electrolytic tinning line at the U.S.Steel s.r.o. Kosice. The work involved is setting up a new network of measuring points, as well as the effective implementation of suitable methodologies, instruments and measuring tools. All of these were focal points for the survey, required during the installation of machinery units for the new tinning line. The coil producing technology utilised on the line entails a high speed movement. In this context all methods and final measurements were adapted to a very high standard of precision in order to ensure a safe working environment and exclude the risk of malfunctions in the final production stage. The smallest variations in the positioning of machinery units, compared with technical drawings, could rise a danger of coil breakdown, line malfunction or personal injury.

Transcription control engineering and applications in synthetic biology

Directory of Open Access Journals (Sweden)

Michael D. Engstrom

2017-09-01

Full Text Available In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. One of these practical applications is control of the flow of genetic information (from nucleic acid to protein, a.k.a. gene regulation. Regulation is critical for optimizing protein (and therefore activity levels and the subsequent levels of metabolites and other cellular properties. The central dogma of molecular biology posits that information flow commences with transcription, and accordingly, regulatory tools targeting transcription have received the most attention in synthetic biology. In this mini-review, we highlight many past successes and summarize the lessons learned in developing tools for controlling transcription. In particular, we focus on engineering studies where promoters and transcription terminators (cis-factors were directly engineered and/or isolated from DNA libraries. We also review several well-characterized transcription regulators (trans-factors, giving examples of how cis- and trans-acting factors have been combined to create digital and analogue switches for regulating transcription in response to various signals. Last, we provide examples of how engineered transcription control systems have been used in metabolic engineering and more complicated genetic circuits. While most of our mini-review focuses on the well-characterized bacterium Escherichia coli, we also provide several examples of the use of transcription control engineering in non-model organisms. Similar approaches have been applied outside the bacterial kingdom indicating that the lessons learned from bacterial studies may be generalized for other organisms.

Transcription control engineering and applications in synthetic biology.

Science.gov (United States)

Engstrom, Michael D; Pfleger, Brian F

2017-09-01

In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. One of these practical applications is control of the flow of genetic information (from nucleic acid to protein), a.k.a. gene regulation. Regulation is critical for optimizing protein (and therefore activity) levels and the subsequent levels of metabolites and other cellular properties. The central dogma of molecular biology posits that information flow commences with transcription, and accordingly, regulatory tools targeting transcription have received the most attention in synthetic biology. In this mini-review, we highlight many past successes and summarize the lessons learned in developing tools for controlling transcription. In particular, we focus on engineering studies where promoters and transcription terminators ( cis -factors) were directly engineered and/or isolated from DNA libraries. We also review several well-characterized transcription regulators ( trans- factors), giving examples of how cis- and trans -acting factors have been combined to create digital and analogue switches for regulating transcription in response to various signals. Last, we provide examples of how engineered transcription control systems have been used in metabolic engineering and more complicated genetic circuits. While most of our mini-review focuses on the well-characterized bacterium Escherichia coli , we also provide several examples of the use of transcription control engineering in non-model organisms. Similar approaches have been applied outside the bacterial kingdom indicating that the lessons learned from bacterial studies may be generalized for other organisms.

11th International Conference on Software Engineering Research, Management and Applications

CERN Document Server

2014-01-01

The purpose of the 11th International Conference on Software Engineering Research, Management and Applications (SERA 2013) held on August 7 - 9, 2012 in Prague, Czech Republic was to bring together scientists, engineers, computer users, and students to share their experiences and exchange new ideas and research results about all aspects (theory, applications and tools) of Software Engineering Research, Management and Applications, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them.   The conference organizers selected 17 outstanding papers from those papers accepted for presentation at the conference in order to publish them in this volume.  The papers were chosen based on review scores submitted by members of the program committee, and further rigorous rounds of review.

Advance elements of optoisolation circuits nonlinearity applications in engineering

CERN Document Server

Aluf, Ofer

2017-01-01

This book on advanced optoisolation circuits for nonlinearity applications in engineering addresses two separate engineering and scientific areas, and presents advanced analysis methods for optoisolation circuits that cover a broad range of engineering applications. The book analyzes optoisolation circuits as linear and nonlinear dynamical systems and their limit cycles, bifurcation, and limit cycle stability by using Floquet theory. Further, it discusses a broad range of bifurcations related to optoisolation systems: cusp-catastrophe, Bautin bifurcation, Andronov-Hopf bifurcation, Bogdanov-Takens (BT) bifurcation, fold Hopf bifurcation, Hopf-Hopf bifurcation, Torus bifurcation (Neimark-Sacker bifurcation), and Saddle-loop or Homoclinic bifurcation. Floquet theory helps as to analyze advance optoisolation systems. Floquet theory is the study of the stability of linear periodic systems in continuous time. Another way to describe Floquet theory, it is the study of linear systems of differential equations with p...

Effect of translucence of engineering ceramics on heat transfer in diesel engines. Final report

Energy Technology Data Exchange (ETDEWEB)

Wahiduzzaman, S.; Morel, T. [Integral Technologies, Inc., Westmont, IL (United States)

1992-04-01

This report describes the experimental portion of a broader study undertaken to assess the effects of translucence of ceramic materials used as thermal barrier coatings in diesel engines. In an earlier analytical work a parametric study was performed, varying several radiative properties over ranges typical of engineering ceramics, thereby identifying the most important radiative properties and their impact on in-cylinder heat transfer. In the current study these properties were experimentally determined for several specific zirconia coatings considered for thermal barrier applications in diesel engines. The methodology of this study involved formulation of a model capable of describing radiative transfer through a semitransparent medium as a function of three independent model parameters, ie, absorption coefficient, scattering coefficient and refractive index. For the zirconia-based ceramics investigated in this study, it was concluded that for usual coating thicknesses (1.5--2.5 mm) these ceramics are optically thick and hence, are effective as radiative heat transfer barriers. These ceramics possess high scattering coefficients and low absorption coefficients causing them to be highly reflective (60-80%) in the spectral region where thermal radiation is important. The performance of the investigated ceramics and the mechanism of heat transfer were found to depend on surface condition, specifically on soot deposition. Thus, to insure the optimum thermal barrier operation for either clean or heavily sooted surfaces, a ceramic material with high scattering coefficient provides the best choice.

Gentic engineering for practical application.

Science.gov (United States)

Klingmüller, W

1979-04-01

Genetic engineering has ushered in a new era in biology. Although many problems are still to be solved, there are examples that point to a possible later application for the benefit of mankind: Bacteria can be manipulated to degrade crude-oil spillages, to produce human insulin and to bind nitrogen from the air. If all the bacteria that are indigenous to agricultural soils could be made to bind nitrogen, an increase in soil fertility might well result.

Gentic engineering for practical application

Energy Technology Data Exchange (ETDEWEB)

Klingmuller, W.

1979-04-01

Genetic engineering has ushered in a new era in biology. Although many problems are still to be solved, there are examples that point to a possible later application for the benefit of mankind: Bacteria can be manipulated to degrade crude-oil spillages, to produce human insulin and to bind nitrogen from the air. If all the bacteria that are indigenous to agricultural soils could be made to bind nitrogen, and increase in soil fertility might well result.

Nonlinear approaches in engineering applications applied mechanics, vibration control, and numerical analysis

CERN Document Server

Jazar, Reza

2015-01-01

This book focuses on the latest applications of nonlinear approaches in different disciplines of engineering. For each selected topic, detailed concept development, derivations, and relevant knowledge are provided for the convenience of the readers. The topics range from dynamic systems and control to optimal approaches in nonlinear dynamics. The volume includes invited chapters from world class experts in the field. The selected topics are of great interest in the fields of engineering and physics and this book is ideal for engineers and researchers working in a broad range of practical topics and approaches. This book also: ·         Explores the most up-to-date applications and underlying principles of nonlinear approaches to problems in engineering and physics, including sections on analytic nonlinearity and practical nonlinearity ·         Enlightens readers to the conceptual significance of nonlinear approaches with examples of applications in scientific and engineering problems from v...

Introduction to plasma engineering

International Nuclear Information System (INIS)

Roth, J.R.

1988-01-01

The author has begun writing a textbook entitled Introduction to Plasma Engineering, which is intended for upper division undergraduates or professionals who are entering the field. This paper features a detailed topical outline of all 20 chapters of the book. The text is organized so that the first five chapters cover plasma physics and basic principles; the next 13 chapters cover the most important engineering applications of plasmas, in order of increasing plasma energy/number density; and two final chapters cover plasma diagnostics and magnetic coil design

[Flexible print circuit technology application in biomedical engineering].

Science.gov (United States)

Jiang, Lihua; Cao, Yi; Zheng, Xiaolin

2013-06-01

Flexible print circuit (FPC) technology has been widely applied in variety of electric circuits with high precision due to its advantages, such as low-cost, high specific fabrication ability, and good flexibility, etc. Recently, this technology has also been used in biomedical engineering, especially in the development of microfluidic chip and microelectrode array. The high specific fabrication can help making microelectrode and other micro-structure equipment. And good flexibility allows the micro devices based on FPC technique to be easily packaged with other parts. In addition, it also reduces the damage of microelectrodes to the tissue. In this paper, the application of FPC technology in biomedical engineering is introduced. Moreover, the important parameters of FPC technique and the development trend of prosperous applications is also discussed.

English Language Writing Anxiety among Final Year Engineering Undergraduates in University Putra Malaysia

Directory of Open Access Journals (Sweden)

Lau Sing Min

2014-08-01

Full Text Available Second Language Writing Anxiety (SLWA is considered one of the most crucial factors affecting all second language learning. This study focused on a group of final year Engineering students’ English Language writing anxiety (N=93 in relation to their gender, race and MUET results. The findings showed that the the male gender, Chinese and MUET band 4 participants faced higher levels of anxiety as compared to the other groups respectively. Somatic anxiety was recorded to be the highest subscale of anxiety faced by most of the participants. The findings of this study can help in making suitable amendments in the engineering programme course structure, especially in determining the suitable English papers to be offered to the students.

Electrospun polyurethane membranes for Tissue Engineering applications

Energy Technology Data Exchange (ETDEWEB)

Gabriel, Laís P., E-mail: lagabriel@gmail.com [National Institute of Biofabrication, Campinas (Brazil); Department of Chemical Engineering, University of Campinas, Campinas (Brazil); Rodrigues, Ana Amélia [National Institute of Biofabrication, Campinas (Brazil); Department of Medical Sciences, University of Campinas, Campinas (Brazil); Macedo, Milton; Jardini, André L.; Maciel Filho, Rubens [National Institute of Biofabrication, Campinas (Brazil); Department of Chemical Engineering, University of Campinas, Campinas (Brazil)

2017-03-01

Tissue Engineering proposes, among other things, tissue regeneration using scaffolds integrated with biological molecules, growth factors or cells for such regeneration. In this research, polyurethane membranes were prepared using the electrospinning technique in order to obtain membranes to be applied in Tissue Engineering, such as epithelial, drug delivery or cardiac applications. The influence of fibers on the structure and morphology of the membranes was studied using scanning electron microscopy (SEM), the structure was evaluated by Fourier transform infrared spectroscopy (FT-IR), and the thermal stability was analyzed by thermogravimetry analysis (TGA). In vitro cells attachment and proliferation was investigated by SEM, and in vitro cell viability was studied by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays and Live/Dead® assays. It was found that the membranes present an homogeneous morphology, high porosity, high surface area/volume ratio, it was also observed a random fiber network. The thermal analysis showed that the membrane degradation started at 254 °C. In vitro evaluation of fibroblasts cells showed that fibroblasts spread over the membrane surface after 24, 48 and 72 h of culture. This study supports the investigation of electrospun polyurethane membranes as biocompatible scaffolds for Tissue Engineering applications and provides some guidelines for improved biomaterials with desired properties.

Application engineering for process computer systems

International Nuclear Information System (INIS)

Mueller, K.

1975-01-01

The variety of tasks for process computers in nuclear power stations necessitates the centralization of all production stages from the planning stage to the delivery of the finished process computer system (PRA) to the user. This so-called 'application engineering' comprises all of the activities connected with the application of the PRA: a) establishment of the PRA concept, b) project counselling, c) handling of offers, d) handling of orders, e) internal handling of orders, f) technical counselling, g) establishing of parameters, h) monitoring deadlines, i) training of customers, j) compiling an operation manual. (orig./AK) [de

76 FR 37085 - Applications for New Awards; Rehabilitation Engineering Research Centers (RERCs)

Science.gov (United States)

2011-06-24

... DEPARTMENT OF EDUCATION Applications for New Awards; Rehabilitation Engineering Research Centers...)--Disability and Rehabilitation Research Projects and Centers Program--Rehabilitation Engineering Research... (Rehabilitation Act). Rehabilitation Engineering Research Centers Program (RERCs) The purpose of the RERC program...

Connecting NASA science and engineering with earth science applications

Science.gov (United States)

The National Research Council (NRC) recently highlighted the dual role of NASA to support both science and applications in planning Earth observations. This Editorial reports the efforts of the NASA Soil Moisture Active Passive (SMAP) mission to integrate applications with science and engineering i...

Nuclear Engine System Simulation (NESS). Volume 1: Program user's guide. Final Report

International Nuclear Information System (INIS)

Pelaccio, D.G.; Scheil, C.M.; Petrosky, L.J.

1993-03-01

A Nuclear Thermal Propulsion (NTP) engine system design analysis tool is required to support current and future Space Exploration Initiative (SEI) propulsion and vehicle design studies. Currently available NTP engine design models are those developed during the NERVA program in the 1960's and early 1970's and are highly unique to that design or are modifications of current liquid propulsion system design models. To date, NTP engine-based liquid design models lack integrated design of key NTP engine design features in the areas of reactor, shielding, multi-propellant capability, and multi-redundant pump feed fuel systems. Additionally, since the SEI effort is in the initial development stage, a robust, verified NTP analysis design tool could be of great use to the community. This effort developed an NTP engine system design analysis program (tool), known as the Nuclear Engine System Simulation (NESS) program, to support ongoing and future engine system and stage design study efforts. In this effort, Science Applications International Corporation's (SAIC) NTP version of the Expanded Liquid Engine Simulation (ELES) program was modified extensively to include Westinghouse Electric Corporation's near-term solid-core reactor design model. The ELES program has extensive capability to conduct preliminary system design analysis of liquid rocket systems and vehicles. The program is modular in nature and is versatile in terms of modeling state-of-the-art component and system options as discussed. The Westinghouse reactor design model, which was integrated in the NESS program, is based on the near-term solid-core ENABLER NTP reactor design concept. This program is now capable of accurately modeling (characterizing) a complete near-term solid-core NTP engine system in great detail, for a number of design options, in an efficient manner

Manipulation of mechanical compliance of elastomeric PGS by incorporation of halloysite nanotubes for soft tissue engineering applications.

Science.gov (United States)

Chen, Qi-Zhi; Liang, Shu-Ling; Wang, Jiang; Simon, George P

2011-11-01

Poly (glycerol sebacate) (PGS) is a promising elastomer for use in soft tissue engineering. However, it is difficult to achieve with PGS a satisfactory balance of mechanical compliance and degradation rate that meet the requirements of soft tissue engineering. In this work, we have synthesised a new PGS nanocomposite system filled with halloysite nanotubes, and mechanical properties, as well as related chemical characters, of the nanocomposites were investigated. It was found that the addition of nanotubular halloysite did not compromise the extensibility of material, compared with the pure PGS counterpart; instead the elongation at rupture was increased from 110 (in the pure PGS) to 225% (in the 20 wt% composite). Second, Young's modulus and resilience of 3-5 wt% composites were ∼0.8 MPa and >94% respectively, remaining close to the level of pure PGS which is desired for applications in soft tissue engineering. Third, an important feature of the 1-5 wt% composites was their stable mechanical properties over an extended period, which could allow the provision of reliable mechanical support to damaged tissues during the lag phase of the healing process. Finally, the in vitro study indicated that the addition of halloysite slowed down the degradation rate of the composites. In conclusion, the good compliance, enhanced stretchability, stable mechanical behavior over an extended period, and reduced degradation rates make the 3-5 wt% composites promising candidates for application in soft tissue engineering. Copyright © 2011 Elsevier Ltd. All rights reserved.

Experiences in the application of human factors engineering to human-system interface modernization

International Nuclear Information System (INIS)

Trueba Alonso, Pedro; Illobre, Luis Fernandez; Ortega Pascual, Fernando

2014-01-01

Almost all the existing Nuclear Power Plants (NPPs) include plans to modernize their existing Instrumentation and Control (I and C) systems and associated Human System Interfaces (HSIs), due to obsolescence problems. Tecnatom, S.A. has been participating in modernization programs in NPPs to help them to plan, specify, design and implement the modernization of control rooms and associated I and C and HSIs. The application of Human Factors Engineering (HFE) in modernization programs is nowadays unavoidable. This is because is becoming a regulatory requirement, and also because it is needed to ensure that any plant modification, involving the modernization of I and C and HSI, is well designed to improve overall plant operations, reliability, and safety. This paper shows some experiences obtained during the application of HFE to the modernization of these HSIs. The experience applying HFE in modernizations and design modifications show a positive effect, improving the associated HSIs, with the acceptability of the final user. (authors)

Experiences in the application of human factors engineering to human-system interface modernization

International Nuclear Information System (INIS)

Trueba Alonso, Pedro; Fernandez Illobre, Luis; Ortega Pascual, Fernando

2015-01-01

Almost all the existing Nuclear Power Plants (NPPs) include plans to modernize their existing Instrumentation and Control (I and C) systems and associated Human System Interfaces (HSIs), due to obsolescence problems. Tecnatom, S.A. has been participating in modernization programs in NPPs to help them to plan, specify, design and implement the modernization of control rooms and associated I and C and HSIs. The application of Human Factors Engineering (HFE) in modernization programs is nowadays unavoidable. This is because is becoming a regulatory requirement, and also because it is needed to ensure that any plant modification, involving the modernization of I and C and HSI, is well designed to improve overall plant operations, reliability, and safety. This paper shows some experiences obtained during the application of HFE to the modernization of these HSIs. The experience applying HFE in modernizations and design modifications show a positive effect, improving the associated HSIs, with the acceptability of the final user.

Experiences in the application of human factors engineering to human-system interface modernization

Energy Technology Data Exchange (ETDEWEB)

Trueba Alonso, Pedro; Fernandez Illobre, Luis; Ortega Pascual, Fernando [Tecnatom S.A., San Sebastian de los Reyes (Spain). Simulation and Control Rooms Div.

2015-07-15

Almost all the existing Nuclear Power Plants (NPPs) include plans to modernize their existing Instrumentation and Control (I and C) systems and associated Human System Interfaces (HSIs), due to obsolescence problems. Tecnatom, S.A. has been participating in modernization programs in NPPs to help them to plan, specify, design and implement the modernization of control rooms and associated I and C and HSIs. The application of Human Factors Engineering (HFE) in modernization programs is nowadays unavoidable. This is because is becoming a regulatory requirement, and also because it is needed to ensure that any plant modification, involving the modernization of I and C and HSI, is well designed to improve overall plant operations, reliability, and safety. This paper shows some experiences obtained during the application of HFE to the modernization of these HSIs. The experience applying HFE in modernizations and design modifications show a positive effect, improving the associated HSIs, with the acceptability of the final user.

Final Technical Report; NUCLEAR ENGINEERING RECRUITMENT EFFORT

Energy Technology Data Exchange (ETDEWEB)

Kerrick, Sharon S.; Vincent, Charles D.

2007-07-02

This report provides the summary of a project whose purpose was to support the costs of developing a nuclear engineering awareness program, an instruction program for teachers to integrate lessons on nuclear science and technology into their existing curricula, and web sites for the exchange of nuclear engineering career information and classroom materials. The specific objectives of the program were as follows: OBJECTIVE 1: INCREASE AWARENESS AND INTEREST OF NUCLEAR ENGINEERING; OBJECTIVE 2: INSTRUCT TEACHERS ON NUCLEAR TOPICS; OBJECTIVE 3: NUCLEAR EDUCATION PROGRAMS WEB-SITE; OBJECTIVE 4: SUPPORT TO UNIVERSITY/INDUSTRY MATCHING GRANTS AND REACTOR SHARING; OBJECTIVE 5: PILOT PROJECT; OBJECTIVE 6: NUCLEAR ENGINEERING ENROLLMENT SURVEY AT UNIVERSITIES

Thermal barrier coatings application in diesel engines

Science.gov (United States)

Fairbanks, J. W.

1995-01-01

Commercial use of thermal barrier coatings in diesel engines began in the mid 70's by Dr. Ingard Kvernes at the Central Institute for Industrial Research in Oslo, Norway. Dr. Kvernes attributed attack on diesel engine valves and piston crowns encountered in marine diesel engines in Norwegian ships as hot-corrosion attributed to a reduced quality of residual fuel. His solution was to coat these components to reduce metal temperature below the threshold of aggressive hot-corrosion and also provide protection. Roy Kamo introduced thermal barrier coatings in his 'Adiabatic Diesel Engine' in the late 70's. Kamo's concept was to eliminate the engine block water cooling system and reduce heat losses. Roy reported significant performance improvements in his thermally insulated engine at the SAE Congress in 1982. Kamo's work stimulates major programs with insulated engines, particularly in Europe. Most of the major diesel engine manufacturers conducted some level of test with insulated combustion chamber components. They initially ran into increased fuel consumption. The German engine consortium had Prof. Woschni of the Technical Institute in Munich. Woschni conducted testing with pistons with air gaps to provide the insulation effects. Woschni indicated the hot walls of the insulated engine created a major increase in heat transfer he refers to as 'convection vive.' Woschni's work was a major factor in the abrupt curtailment of insulated diesel engine work in continental Europe. Ricardo in the UK suggested that combustion should be reoptimized for the hot-wall effects of the insulated combustion chamber and showed under a narrow range of conditions fuel economy could be improved. The Department of Energy has supported thermal barrier coating development for diesel engine applications. In the Clean Diesel - 50 Percent Efficient (CD-50) engine for the year 2000, thermal barrier coatings will be used on piston crowns and possibly other components. The primary purpose of the

Development and engineering application of rotating drum acid-curing equipment in uranium mills

International Nuclear Information System (INIS)

Liu Wenhua

2006-01-01

The development and engineering application of rotating drum acid-curing equipment for 'strong acid-curing and ferri-trickle leaching' process are introduced, including the design of main structure, problems appeared in the development and engineering application, and methods solved. (authors)

Engineering of Droplet Manipulation in Tertiary Junction Microfluidic Channels

Science.gov (United States)

2017-06-30

mechanics point-of-view, the larger motivation to carry out this research work derives from its application in biomedical engineering for sorting CTCs...AFRL-AFOSR-JP-TR-2017-0055 Engineering of Droplet Manipulation in Tertiary Junction Microfluidic Channels Shalini Gupta INDIAN INSTITUTE OF...2017 2. REPORT TYPE Final 3. DATES COVERED (From - To) 14 May 2015 to 13 Nov 2016 4. TITLE AND SUBTITLE Engineering of Droplet Manipulation in

Applications of artificial intelligence in engineering problems. Vol. 1 and 2. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Sriram, D; Adey, R [eds.

1986-01-01

The purpose of the first international conference on the application of AI to engineering problems is to provide a forum for engineers all over the world to present their work on these applications. The interest being shown in the engineering community is evident by the large number of papers from the conference that are compiled into these volumes. The topics span various engineering disciplines. These topics are grouped into the following categories: - Knowledge representation and acquisition. Robotics. Natural language processing. Inexact inference techniques. General design methodologies. Constraints. Design strategies specific to a particular domain. Diagnostic systems. Intelligent front ends. Tools and techniques for building expert systems. Most of the papers deal with knowledge-based expert systems. In addition to the regular sessions, two sessions discussing a number of ongoing projects were also included in the conference. A panel on the future of AI in the engineering industry and another panel on networking were scheduled. Distinguished invited speakers from academia and industry presented lectures on their experiences with the application of AI.

Advanced materials and protective coatings in aero-engines application

OpenAIRE

M. Hetmańczyk; L. Swadźba; B. Mendala

2007-01-01

Purpose: The following article demonstrates the characteristics of the materials applied as parts of aircraft engine turbines and the stationary gas turbines. The principal technologies for manufacturing the heat resistant coatings and the erosion and corrosion resistant coatings were characterized. Sample applications for the aforementioned coatings are presented: on turbine blades, compressor blades and on parts of combustion chambers of aircraft engines.Design/methodology/approach: The nic...

Customizing CAD system and its application for engineering design

International Nuclear Information System (INIS)

Shin, Jeong Ho; Kwak, Byung Man

2003-01-01

The computer is an important tool to design an engineering system and CAD systems are widely used for various design practice. To meet the market requirements, the old mass production system is being changed into the mass customization system. As for CAD systems, it is increasingly required to extend, automate, and customize a wide range of functionality. This article describes the state-of-the-art of the principal technologies for customizing CAD systems. And we have implemented an application that enables the parametric design by directly inputting numerical values of parameters for a CAD model. Based on this application, we have developed another system that makes it possible sharing of part family data between SolidEdge and Pro/Engineer. Through customization of CAD systems, it is possible to improve the product quality using external knowledge-based systems or to integrate with external system such as CAE tools. This paper can be a guide for engineering designers who want to customize CAD systems

Search Engine Liability for Copyright Infringement

Science.gov (United States)

Fitzgerald, B.; O'Brien, D.; Fitzgerald, A.

The chapter provides a broad overview to the topic of search engine liability for copyright infringement. In doing so, the chapter examines some of the key copyright law principles and their application to search engines. The chapter also provides a discussion of some of the most important cases to be decided within the courts of the United States, Australia, China and Europe regarding the liability of search engines for copyright infringement. Finally, the chapter will conclude with some thoughts for reform, including how copyright law can be amended in order to accommodate and realise the great informative power which search engines have to offer society.

48 CFR 836.606-73 - Application of 6 percent architect-engineer fee limitation.

Science.gov (United States)

2010-10-01

... architect-engineer fee limitation. 836.606-73 Section 836.606-73 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 836.606-73 Application of 6 percent architect-engineer fee limitation...

Mechanical Engineering Senior Design Project Final Presentations | College

Science.gov (United States)

Engineering Research Computational Mechanics Laboratory Environmental Engineering Laboratory Geotechnical of Engineering & Applied Science A B C D E F G H I J K L M N O P Q R S T U V W X Y Z D2L Programs Concentration in Biomedical Engineering Concentration on Ergonomics M.S. Program in Computer

The application of human engineering in control room of HFETR

International Nuclear Information System (INIS)

Yang Shuchun; Shan Songlin

2003-01-01

The human-machine system for improving the working environment in the control room of HFETR is described. The reliability of the equipment, instruments and operation by human engineering is increased. The relations between human engineering and lowering human failure in HFETR are also discussed. It is concluded that the further application of human engineering can increase interaction of the human and machine in the control room and provide assurances for the safe and reliable operation of reactor. (authors)

The application of human engineering in control room of HFETR

Energy Technology Data Exchange (ETDEWEB)

Shuchun, Yang; Songlin, Shan [Nuclear Power Inst. of China, Chengdu (China)

2003-07-01

The human-machine system for improving the working environment in the control room of HFETR is described. The reliability of the equipment, instruments and operation by human engineering is increased. The relations between human engineering and lowering human failure in HFETR are also discussed. It is concluded that the further application of human engineering can increase interaction of the human and machine in the control room and provide assurances for the safe and reliable operation of reactor. (authors)

Computer, Network, Software, and Hardware Engineering with Applications

CERN Document Server

Schneidewind, Norman F

2012-01-01

There are many books on computers, networks, and software engineering but none that integrate the three with applications. Integration is important because, increasingly, software dominates the performance, reliability, maintainability, and availability of complex computer and systems. Books on software engineering typically portray software as if it exists in a vacuum with no relationship to the wider system. This is wrong because a system is more than software. It is comprised of people, organizations, processes, hardware, and software. All of these components must be considered in an integr

Advanced FDTD methods parallelization, acceleration, and engineering applications

CERN Document Server

Yu, Wenhua

2011-01-01

The finite-difference time-domain (FDTD) method has revolutionized antenna design and electromagnetics engineering. Here's a cutting-edge book that focuses on the performance optimization and engineering applications of FDTD simulation systems. Covering the latest developments in this area, this unique resource offer you expert advice on the FDTD method, hardware platforms, and network systems. Moreover the book offers guidance in distinguishing between the many different electromagnetics software packages on the market today. You also find a complete chapter dedicated to large multi-scale pro

Master on Nuclear Engineering and Applications (MINA): instrument of knowledge management in the nuclear sector; Master en Ingenieria Nuclear y Aplicaciones (MINA): instrumento de gestion del conocimiento en el sector nuclear espanol

Energy Technology Data Exchange (ETDEWEB)

Herranz, L. E.; Garcia Cuesta, J. C.; Falcon, S.; Casas, J. A.

2013-03-01

Knowledge Management in nuclear industry is indispensable to ensure excellence in performance and safety of nuclear installations. The Master on Nuclear Engineering and Applications (MINA) is a Spanish education venture which foundations and evolution have meant and adaptation to the European Education system and to the domestic and international changes occurred in the nuclear environment. This paper summarizes the most relevant aspects of such transformation, its motivation and the final outcome. Finally, it discusses the potential benefit of a closer collaboration among the existing national education ventures in the frame of Nuclear Engineering. (Author)

Piezoelectric polymers as biomaterials for tissue engineering applications.

Science.gov (United States)

Ribeiro, Clarisse; Sencadas, Vítor; Correia, Daniela M; Lanceros-Méndez, Senentxu

2015-12-01

Tissue engineering often rely on scaffolds for supporting cell differentiation and growth. Novel paradigms for tissue engineering include the need of active or smart scaffolds in order to properly regenerate specific tissues. In particular, as electrical and electromechanical clues are among the most relevant ones in determining tissue functionality in tissues such as muscle and bone, among others, electroactive materials and, in particular, piezoelectric ones, show strong potential for novel tissue engineering strategies, in particular taking also into account the existence of these phenomena within some specific tissues, indicating their requirement also during tissue regeneration. This referee reports on piezoelectric materials used for tissue engineering applications. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and a start point for novel research pathways in the most relevant and challenging open questions. Copyright © 2015 Elsevier B.V. All rights reserved.

Genome-scale modeling for metabolic engineering.

Science.gov (United States)

Simeonidis, Evangelos; Price, Nathan D

2015-03-01

We focus on the application of constraint-based methodologies and, more specifically, flux balance analysis in the field of metabolic engineering, and enumerate recent developments and successes of the field. We also review computational frameworks that have been developed with the express purpose of automatically selecting optimal gene deletions for achieving improved production of a chemical of interest. The application of flux balance analysis methods in rational metabolic engineering requires a metabolic network reconstruction and a corresponding in silico metabolic model for the microorganism in question. For this reason, we additionally present a brief overview of automated reconstruction techniques. Finally, we emphasize the importance of integrating metabolic networks with regulatory information-an area which we expect will become increasingly important for metabolic engineering-and present recent developments in the field of metabolic and regulatory integration.

Engineering applications of heuristic multilevel optimization methods

Science.gov (United States)

Barthelemy, Jean-Francois M.

1989-01-01

Some engineering applications of heuristic multilevel optimization methods are presented and the discussion focuses on the dependency matrix that indicates the relationship between problem functions and variables. Coordination of the subproblem optimizations is shown to be typically achieved through the use of exact or approximate sensitivity analysis. Areas for further development are identified.

Nano-Engineered Hierarchical Advanced Composite Materials for Space Applications

Data.gov (United States)

National Aeronautics and Space Administration — Composites are widely used throughout aerospace engineering and in numerous other applications where structures that possess high strength and toughness properties...

10 CFR 52.157 - Contents of applications; technical information in final safety analysis report.

Science.gov (United States)

2010-01-01

...; technical information in final safety analysis report. The application must contain a final safety analysis... 10 Energy 2 2010-01-01 2010-01-01 false Contents of applications; technical information in final safety analysis report. 52.157 Section 52.157 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES...

10 CFR 52.79 - Contents of applications; technical information in final safety analysis report.

Science.gov (United States)

2010-01-01

...; technical information in final safety analysis report. (a) The application must contain a final safety... 10 Energy 2 2010-01-01 2010-01-01 false Contents of applications; technical information in final safety analysis report. 52.79 Section 52.79 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES...

Deformation and fracture of solid-state materials field theoretical approach and engineering applications

CERN Document Server

Yoshida, Sanichiro

2015-01-01

This book introduces a comprehensive theory of deformation and fracture to engineers and applied scientists. The author explains the gist of local symmetry (gauge invariance) intuitively so that engineers and applied physicists can digest it easily, rather than describing physical or mathematical details of the principle. Applications of the theory to practical engineering are also described, such as nondestructive testing, in particular, with the use of an optical interferometric technique called ESPI (Electronic Speckle-Pattern Interferometry). The book provides information on how to apply physical concepts to engineering applications. This book also: ·         Describes a highly original way to reveal loading hysteresis of a given specimen ·         Presents a fundamentally new approach to deformation and fracture, which offers potential for new applications ·         Introduces the unique application of Electric Speckle-Pattern Interferometry—reading fringe patterns to connect...

English Language Writing Anxiety among Final Year Engineering Undergraduates in University Putra Malaysia

OpenAIRE

Lau Sing Min; Nurhazlini Rahmat

2014-01-01

Second Language Writing Anxiety (SLWA) is considered one of the most crucial factors affecting all second language learning. This study focused on a group of final year Engineering students’ English Language writing anxiety (N=93) in relation to their gender, race and MUET results. The findings showed that the the male gender, Chinese and MUET band 4 participants faced higher levels of anxiety as compared to the other groups respectively. Somatic anxiety was recorded to be the highest subscal...

Heat transfer applications for the practicing engineer

CERN Document Server

Theodore, Louis

2011-01-01

This book serves as a training tool for individuals in industry and academia involved with heat transfer applications. Although the literature is inundated with texts emphasizing theory and theoretical derivations, the goal of this book is to present the subject of heat transfer from a strictly pragmatic point of view. The book is divided into four Parts: Introduction, Principles, Equipment Design Procedures and Applications, and ABET-related Topics. The first Part provides a series of chapters concerned with introductory topics that are required when solving most engineering problems, inclu

CRISPR Mediated Genome Engineering and its Application in Industry.

Science.gov (United States)

Kaboli, Saeed; Babazada, Hasan

2018-01-01

The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated nuclease 9) method has been dramatically changing the field of genome engineering. It is a rapid, highly efficient and versatile tool for precise modification of genome that uses a guide RNA (gRNA) to target Cas9 to a specific sequence. This novel RNA-guided genome-editing technique has become a revolutionary tool in biomedical science and has many innovative applications in different fields. In this review, we briefly introduce the Cas9-mediated genome-editing tool, summarize the recent advances in CRISPR/Cas9 technology to engineer the genomes of a wide variety of organisms, and discuss their applications to treatment of fungal and viral disease. We also discuss advantageous of CRISPR/Cas9 technology to drug design, creation of animal model, and to food, agricultural and energy sciences. Adoption of the CRISPR/Cas9 technology in biomedical and biotechnological researches would create innovative applications of it not only for breeding of strains exhibiting desired traits for specific industrial and medical applications, but also for investigation of genome function.

Enzymatically biomineralized chitosan scaffolds for tissue-engineering applications.

NARCIS (Netherlands)

Dash, M.; Samal, S.K.; Douglas, T.E.L.; Schaubroeck, D.; Leeuwenburgh, S.C.G.; Voort, P. van der; Declercq, H.A.; Dubruel, P.

2017-01-01

Porous biodegradable scaffolds represent promising candidates for tissue-engineering applications because of their capability to be preseeded with cells. We report an uncrosslinked chitosan scaffold designed with the aim of inducing and supporting enzyme-mediated formation of apatite minerals in the

Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.

Science.gov (United States)

Nae, S; Bordeianu, I; Stăncioiu, A T; Antohi, N

2013-01-01

Recent researches have demonstrated that the most effective repair system of the body is represented by stem cells - unspecialized cells, capable of self-renewal through successive mitoses, which have also the ability to transform into different cell types through differentiation. The discovery of adult stem cells represented an important step in regenerative medicine because they no longer raises ethical or legal issues and are more accessible. Only in 2002, stem cells isolated from adipose tissue were described as multipotent stem cells. Adipose tissue stem cells benefits in tissue engineering and regenerative medicine are numerous. Development of adipose tissue engineering techniques offers a great potential in surpassing the existing limits faced by the classical approaches used in plastic and reconstructive surgery. Adipose tissue engineering clinical applications are wide and varied, including reconstructive, corrective and cosmetic procedures. Nowadays, adipose tissue engineering is a fast developing field, both in terms of fundamental researches and medical applications, addressing issues related to current clinical pathology or trauma management of soft tissue injuries in different body locations.

Rapid prototyping technology and its application in bone tissue engineering.

Science.gov (United States)

Yuan, Bo; Zhou, Sheng-Yuan; Chen, Xiong-Sheng

Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.

Rapid prototyping technology and its application in bone tissue engineering*

Science.gov (United States)

YUAN, Bo; ZHOU, Sheng-yuan; CHEN, Xiong-sheng

2017-01-01

Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects. PMID:28378568

Implementation of Scientific Computing Applications on the Cell Broadband Engine

Directory of Open Access Journals (Sweden)

Guochun Shi

2009-01-01

Full Text Available The Cell Broadband Engine architecture is a revolutionary processor architecture well suited for many scientific codes. This paper reports on an effort to implement several traditional high-performance scientific computing applications on the Cell Broadband Engine processor, including molecular dynamics, quantum chromodynamics and quantum chemistry codes. The paper discusses data and code restructuring strategies necessary to adapt the applications to the intrinsic properties of the Cell processor and demonstrates performance improvements achieved on the Cell architecture. It concludes with the lessons learned and provides practical recommendations on optimization techniques that are believed to be most appropriate.

Probability with applications to investments, insurance, and engineering

CERN Document Server

Bean, Michael A

2009-01-01

This book covers the basic probability of distributions with an emphasis on applications from the areas of investments, insurance, and engineering. Written by a Fellow of the Casualty Actuarial Society and the Society of Actuaries with many years of experience as a university professor and industry practitioner, the book is suitable as a text for senior undergraduate and beginning graduate students in mathematics, statistics, actuarial science, finance, or engineering as well as a reference for practitioners in these fields. The book is particularly well suited for students preparing for profe

Electrospinning of Nanofibers for Tissue Engineering Applications

Directory of Open Access Journals (Sweden)

Haifeng Liu

2013-01-01

Full Text Available Electrospinning is a method in which materials in solution are formed into nano- and micro-sized continuous fibers. Recent interest in this technique stems from both the topical nature of nanoscale material fabrication and the considerable potential for use of these nanoscale fibres in a range of applications including, amongst others, a range of biomedical applications processes such as drug delivery and the use of scaffolds to provide a framework for tissue regeneration in both soft and hard tissue applications systems. The objectives of this review are to describe the theory behind the technique, examine the effect of changing the process parameters on fiber morphology, and discuss the application and impact of electrospinning on the fields of vascular, neural, bone, cartilage, and tendon/ligament tissue engineering.

Vision systems for scientific and engineering applications

International Nuclear Information System (INIS)

Chadda, V.K.

2009-01-01

Human performance can get degraded due to boredom, distraction and fatigue in vision-related tasks such as measurement, counting etc. Vision based techniques are increasingly being employed in many scientific and engineering applications. Notable advances in this field are emerging from continuing improvements in the fields of sensors and related technologies, and advances in computer hardware and software. Automation utilizing vision-based systems can perform repetitive tasks faster and more accurately, with greater consistency over time than humans. Electronics and Instrumentation Services Division has developed vision-based systems for several applications to perform tasks such as precision alignment, biometric access control, measurement, counting etc. This paper describes in brief four such applications. (author)

The System Concept and Its Application to Engineering

CERN Document Server

Aslaksen, Erik W

2013-01-01

Systems engineering is a mandatory approach in some industries, and is gaining wider acceptance for complex projects in general. However, under the imperative of delivering these projects on time and within budget, the focus has been mainly on the management aspects, with less attention to improving the core engineering activity – design. This book addresses the application of the system concept to design in several ways: by developing a deeper understanding of the system concept, by defining design and its characteristics within the process of engineering, and by applying the system concept to the early stage of design, where it has the greatest impact.   A central theme of the book is that the purpose of engineering is to be useful in meeting the needs of society, and that therefore the ultimate measure of the benefit of applying the system concept should be the extent to which it advances the achievement of that purpose. Consequently, any consistent, top-down development of the functionality required of...

LCCP Desktop Application v1.0 Engineering Reference

Energy Technology Data Exchange (ETDEWEB)

Beshr, Mohamed [Univ. of Maryland, College Park, MD (United States); Aute, Vikrant [Univ. of Maryland, College Park, MD (United States)

2014-04-01

This Life Cycle Climate Performance (LCCP) Desktop Application Engineering Reference is divided into three parts. The first part of the guide, consisting of the LCCP objective, literature review, and mathematical background, is presented in Sections 2-4. The second part of the guide (given in Sections 5-10) provides a description of the input data required by the LCCP desktop application, including each of the input pages (Application Information, Load Information, and Simulation Information) and details for interfacing the LCCP Desktop Application with the VapCyc and EnergyPlus simulation programs. The third part of the guide (given in Section 11) describes the various interfaces of the LCCP code.

Applications of synchrotron radiation to Chemical Engineering Science: Workshop report

International Nuclear Information System (INIS)

1991-07-01

This report contains extended abstracts that summarize presentations made at the Workshop on Applications of Synchrotron Radiation to Chemical Engineering Science held at Argonne National Laboratory (ANL), Argonne, IL, on April 22--23, 1991. The talks emphasized the application of techniques involving absorption fluorescence, diffraction, and reflection of synchrotron x-rays, with a focus on problems in applied chemistry and chemical engineering, as well as on the use of x-rays in topographic, tomographic, and lithographic procedures. The attendees at the workshop included experts in the field of synchrotron science, scientists and engineers from ANL, other national laboratories, industry, and universities; and graduate and undergraduate students who were enrolled in ANL educational programs at the time of the workshop. Talks in the Plenary and Overview Session described the status of and special capabilities to be offered by the Advanced Photon Source (APS), as well as strategies and opportunities for utilization of synchrotron radiation to solve science and engineering problems. Invited talks given in subsequent sessions covered the use of intense infrared, ultraviolet, and x-ray photon beams (as provided by synchrotrons) in traditional and nontraditional areas of chemical engineering research related to electrochemical and corrosion science, catalyst development and characterization, lithography and imaging techniques, and microanalysis

Applications of synchrotron radiation to Chemical Engineering Science: Workshop report

Energy Technology Data Exchange (ETDEWEB)

1991-07-01

This report contains extended abstracts that summarize presentations made at the Workshop on Applications of Synchrotron Radiation to Chemical Engineering Science held at Argonne National Laboratory (ANL), Argonne, IL, on April 22--23, 1991. The talks emphasized the application of techniques involving absorption fluorescence, diffraction, and reflection of synchrotron x-rays, with a focus on problems in applied chemistry and chemical engineering, as well as on the use of x-rays in topographic, tomographic, and lithographic procedures. The attendees at the workshop included experts in the field of synchrotron science, scientists and engineers from ANL, other national laboratories, industry, and universities; and graduate and undergraduate students who were enrolled in ANL educational programs at the time of the workshop. Talks in the Plenary and Overview Session described the status of and special capabilities to be offered by the Advanced Photon Source (APS), as well as strategies and opportunities for utilization of synchrotron radiation to solve science and engineering problems. Invited talks given in subsequent sessions covered the use of intense infrared, ultraviolet, and x-ray photon beams (as provided by synchrotrons) in traditional and nontraditional areas of chemical engineering research related to electrochemical and corrosion science, catalyst development and characterization, lithography and imaging techniques, and microanalysis.

Applications of computational modeling in metabolic engineering of yeast

DEFF Research Database (Denmark)

Kerkhoven, Eduard J.; Lahtvee, Petri-Jaan; Nielsen, Jens

2015-01-01

a preferred flux distribution. These methods point to strategies for altering gene expression; however, fluxes are often controlled by post-transcriptional events. Moreover, GEMs are usually not taking into account metabolic regulation, thermodynamics and enzyme kinetics. To facilitate metabolic engineering......, it is necessary to expand the modeling of metabolism to consider kinetics of individual processes. This review will give an overview about models available for metabolic engineering of yeast and discusses their applications....

Rational engineering of physicochemical properties of nanomaterials for biomedical applications with nanotoxicological perspectives.

Science.gov (United States)

Navya, P N; Daima, Hemant Kumar

2016-01-01

Innovative engineered nanomaterials are at the leading edge of rapidly emerging fields of nanobiotechnology and nanomedicine. Meticulous synthesis, unique physicochemical properties, manifestation of chemical or biological moieties on the surface of materials make engineered nanostructures suitable for a variety of biomedical applications. Besides, tailored nanomaterials exhibit entirely novel therapeutic applications with better functionality, sensitivity, efficiency and specificity due to their customized unique physicochemical and surface properties. Additionally, such designer made nanomaterials has potential to generate series of interactions with various biological entities including DNA, proteins, membranes, cells and organelles at nano-bio interface. These nano-bio interactions are driven by colloidal forces and predominantly depend on the dynamic physicochemical and surface properties of nanomaterials. Nevertheless, recent development and atomic scale tailoring of various physical, chemical and surface properties of nanomaterials is promising to dictate their interaction in anticipated manner with biological entities for biomedical applications. As a result, rationally designed nanomaterials are in extensive demand for bio-molecular detection and diagnostics, therapeutics, drug and gene delivery, fluorescent labelling, tissue engineering, biochemical sensing and other pharmaceuticals applications. However, toxicity and risk associated with engineered nanomaterials is rather unclear or not well understood; which is gaining considerable attention and the field of nanotoxicology is evolving promptly. Therefore, this review explores current knowledge of articulate engineering of nanomaterials for biomedical applications with special attention on potential toxicological perspectives.

Chemical Reaction Engineering Applications in Non-traditional Technologies. A Textbook Supplement.

Science.gov (United States)

Savage, Phillip E.; Blaine, Steven

1991-01-01

A set of educational materials that have been developed which deal with chemical engineering applications in emerging technologies is described. The organization and the content of the supplemental textbook materials and how they can be integrated into an undergraduate reaction engineering course are discussed. (KR)

Molecular and multiscale modeling: review on the theories and applications in chemical engineering

International Nuclear Information System (INIS)

Morales M, Giovanni; Martinez R, Ramiro

2010-01-01

We call molecular modeling to the application of suitable laws in the analysis of phenomena occurred at scales less than those accounted for by the macroscopic world. Such different scales (including micro-, meso- and macro scales), can be linked and integrated in order to improve understanding and predictions of complex physical chemistry phenomena, thus originating a global or multi scale analysis. A considerable amount of chemical engineering phenomena are complex due to the interrelation among these different realms of length and time. Multi scale modeling rises as an alternative for an outstanding mathematical and conceptual representation of such phenomena. This adequate representation may help to design and optimize chemical and petrochemical processes from a microscopic point of view. Herein we present a brief introduction to both molecular and multi scale modeling methods. We also comment and examine opportunities for applying the different levels of modeling to the analysis of industrial problems. The fundamental mathematical machinery of the molecular modelling theories is presented in order to motivate the study of these new engineering tools. Finally, we show a classification of different strategies for applying multilevel analysis, illustrating various examples of each methodology.

Metabolic engineering of Yarrowia lipolytica for industrial applications.

Science.gov (United States)

Zhu, Quinn; Jackson, Ethel N

2015-12-01

Yarrowia lipolytica is a safe and robust yeast that has a history of industrial applications. Its physiological, metabolic and genomic characteristics have made it a superior host for metabolic engineering. The results of optimizing internal pathways and introducing new pathways have demonstrated that Y. lipolytica can be a platform cell factory for cost-effective production of chemicals and fuels derived from fatty acids, lipids and acetyl-CoA. Two products have been commercialized from metabolically engineered Y. lipolytica strains producing high amounts of omega-3 eicosapentaenoic acid, and more products are on the way to be produced at industrial scale. Here we review recent progress in metabolic engineering of Y. lipolytica for production of biodiesel fuel, functional fatty acids and carotenoids. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Computational Modeling in Tissue Engineering

CERN Document Server

2013-01-01

One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in:  (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each...

4th International Conference in Software Engineering for Defence Applications

CERN Document Server

Sillitti, Alberto; Succi, Giancarlo; Messina, Angelo

2016-01-01

This book presents high-quality original contributions on new software engineering models, approaches, methods, and tools and their evaluation in the context of defence and security applications. In addition, important business and economic aspects are discussed, with a particular focus on cost/benefit analysis, new business models, organizational evolution, and business intelligence systems. The contents are based on presentations delivered at SEDA 2015, the 4th International Conference in Software Engineering for Defence Applications, which was held in Rome, Italy, in May 2015. This conference series represents a targeted response to the growing need for research that reports and debates the practical implications of software engineering within the defence environment and also for software performance evaluation in real settings through controlled experiments as well as case and field studies. The book will appeal to all with an interest in modeling, managing, and implementing defence-related software devel...

Inequalities with applications to engineering

CERN Document Server

Cloud, Michael J; Lebedev, Leonid P

2014-01-01

This book offers a concise introduction to mathematical inequalities for graduate students and researchers in the fields of engineering and applied mathematics. It begins by reviewing essential facts from algebra and calculus and proceeds with a presentation of the central inequalities of applied analysis, illustrating a wide variety of practical applications. The text provides a gentle introduction to abstract spaces, such as metric, normed, and inner product spaces. It also provides full coverage of the central inequalities of applied analysis, such as Young's inequality, the inequality of the means, Hölder's inequality, Minkowski's inequality, the Cauchy–Schwarz inequality, Chebyshev's inequality, Jensen's inequality, and the triangle inequality. The second edition features extended coverage of applications, including continuum mechanics and interval analysis. It also includes many additional examples and exercises with hints and full solutions that may appeal to upper-level undergraduate and graduate...

Institute for Computer Applications in Science and Engineering (ICASE)

Science.gov (United States)

1984-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis and computer science during the period April 1, 1983 through September 30, 1983 is summarized.

Application of Crushed Concrete in Geotechnical Engineering - Selected Issues

Science.gov (United States)

Kawalec, Jacek; Kwiecien, Slawomir; Pilipenko, Anton; Rybak, Jarosław

2017-12-01

The reuse of building materials becomes an important issue in sustainable engineering. As the technical requirements for civil engineering structures changes with time and the life time is limited, the need of building new objects meets the necessity of recycling of the existing ones. In the case of steel structures, the possibility of recycling is obvious, also in the case of wooden constructions, the possibility of “burning” solves the problem. The concrete waste is generated mainly as a result of the demolition and reconstruction of residential and industrial buildings. These types of waste are basically made from crushed rocks and cement minerals and contain non-hydrated cement particles in its composition. Concrete poses a lot of problems mainly for two reasons. It is difficult to crush, heavy and hard to transport and demanding in reuse. Different fractions (particle sizes) may be used for different purposes. Starting from very fine particles which can be used in concrete production, through regular 16-300 mm fractions used to form new fills and fill the mats, up to very irregular mixtures used to form stone columns by means of Impulse Compaction or in Dynamic Replacement. The presented study juxtaposes authors experience with crushed concrete used in civil engineering, mainly in geotechnical projects. Authors’ experiences comprise the application of crushed concrete in the new concrete production in Russia, changing pulverized bridge into the fill of mesh sacks, or mattresses used as an effective way to protect the shoreline and the New Orleans East land bridge after Katrina storm (forming a new shoreline better able to withstand wave actions), and finally the use of very irregular concrete fractions to form stone columns in week soils on the example of railway and road projects in Poland. Selected case studies are presented and summarized with regard to social, technical and economic issues including energy consumption needed for proposed technologies

Reverse Engineering and Software Products Reuse to Teach Collaborative Web Portals: A Case Study with Final-Year Computer Science Students

Science.gov (United States)

Medina-Dominguez, Fuensanta; Sanchez-Segura, Maria-Isabel; Mora-Soto, Arturo; Amescua, Antonio

2010-01-01

The development of collaborative Web applications does not follow a software engineering methodology. This is because when university students study Web applications in general, and collaborative Web portals in particular, they are not being trained in the use of software engineering techniques to develop collaborative Web portals. This paper…

A study of the Armstrong Whitworth swing beam engine for automotive application

Science.gov (United States)

1983-01-01

The introduction of ceramics to those parts suffering high thermal loading was successfully demonstrated, and there is no question that the 100 kw (134 hp) naturally aspirated engine of the future will be developed to produce up to 300 kw (402 hp) by the application of turbocharging or its equivalent. However, at the 60 - 80 kw (80 - 107 hp) size needed for the economic automotive engine, scaling down the 300 kw (402 hp) is beset by the laws of scale. The conventional four stroke diesel was not shown to be successful at the small high speed engine size. The opposed piston two stroke engine does not suffer the same laws of scale and engines in the low power range have already been marketed successfully. The half liter/cylinder Armstrong Whitworth Swing Beam Engine is the latest to be designed with the automotive market in mind. Its low noise structure and balanced linkage system coupled with advantages for easy start and potential use of low grade fuels, derived from its variable compression ratio and slow piston motion, qualifies it for the application.

Development of improved processing and evaluation methods for high reliability structural ceramics for advanced heat engine applications, Phase 1. Final report

Energy Technology Data Exchange (ETDEWEB)

Pujari, V.K.; Tracey, D.M.; Foley, M.R.; Paille, N.I.; Pelletier, P.J.; Sales, L.C.; Wilkens, C.A.; Yeckley, R.L. [Norton Co., Northboro, MA (United States)

1993-08-01

The program goals were to develop and demonstrate significant improvements in processing methods, process controls and non-destructive evaluation (NDE) which can be commercially implemented to produce high reliability silicon nitride components for advanced heat engine applications at temperatures to 1,370{degrees}C. The program focused on a Si{sub 3}N{sub 4}-4% Y{sub 2}O{sub 3} high temperature ceramic composition and hot-isostatic-pressing as the method of densification. Stage I had as major objectives: (1) comparing injection molding and colloidal consolidation process routes, and selecting one route for subsequent optimization, (2) comparing the performance of water milled and alcohol milled powder and selecting one on the basis of performance data, and (3) adapting several NDE methods to the needs of ceramic processing. The NDE methods considered were microfocus X-ray radiography, computed tomography, ultrasonics, NMR imaging, NMR spectroscopy, fluorescent liquid dye penetrant and X-ray diffraction residual stress analysis. The colloidal consolidation process route was selected and approved as the forming technique for the remainder of the program. The material produced by the final Stage II optimized process has been given the designation NCX 5102 silicon nitride. According to plan, a large number of specimens were produced and tested during Stage III to establish a statistically robust room temperature tensile strength database for this material. Highlights of the Stage III process demonstration and resultant database are included in the main text of the report, along with a synopsis of the NCX-5102 aqueous based colloidal process. The R and D accomplishments for Stage I are discussed in Appendices 1--4, while the tensile strength-fractography database for the Stage III NCX-5102 process demonstration is provided in Appendix 5. 4 refs., 108 figs., 23 tabs.

Applications and issues of GIS as tool for civil engineering modeling

Science.gov (United States)

Miles, S.B.; Ho, C.L.

1999-01-01

A tool that has proliferated within civil engineering in recent years is geographic information systems (GIS). The goal of a tool is to supplement ability and knowledge that already exists, not to serve as a replacement for that which is lacking. To secure the benefits and avoid misuse of a burgeoning tool, engineers must understand the limitations, alternatives, and context of the tool. The common benefits of using GIS as a supplement to engineering modeling are summarized. Several brief case studies of GIS modeling applications are taken from popular civil engineering literature to demonstrate the wide use and varied implementation of GIS across the discipline. Drawing from the case studies, limitations regarding traditional GIS data models find the implementation of civil engineering models within current GIS are identified and countered by discussing the direction of the next generation of GIS. The paper concludes by highlighting the potential for the misuse of GIS in the context of engineering modeling and suggests that this potential can be reduced through education and awareness. The goal of this paper is to promote awareness of the issues related to GIS-based modeling and to assist in the formulation of questions regarding the application of current GIS. The technology has experienced much publicity of late, with many engineers being perhaps too excited about the usefulness of current GIS. An undoubtedly beneficial side effect of this, however, is that engineers are becoming more aware of GIS and, hopefully, the associated subtleties. Civil engineers must stay informed of GIS issues and progress, but more importantly, civil engineers must inform the GIS community to direct the technology development optimally.

Neutrons and synchrotron radiation in engineering materials science. From fundamentals to applications. 2. ed.

Energy Technology Data Exchange (ETDEWEB)

Staron, Peter [Helmholtz-Zentrum Geesthacht, Zentrum fuer Material- und Kuestenforschung GmbH, Geesthacht (Germany). Inst. of Materials Research; Schreyer, Andreas [European Spallation Source ERIC, Lund (Sweden); Clemens, Helmut; Mayer, Svea (eds.) [Montanuniv. Leoben (Austria). Dept. of Physical Metallurgy and Materials Testing

2017-07-01

This book provides a systematic overview of the increasingly important field of characterization of engineering materials with the help of neutrons and synchrotron radiation. The first part introduces readers to the fundamentals of structure-property relationships in materials and the radiation sources suitable for materials characterization. The second part then focuses on such characterization techniques as diffraction and scattering methods, as well as direct imaging and tomography. The third part presents new and emerging methods of materials characterization in the field of 3D characterization techniques like three-dimensional X-ray diffraction microscopy. The fourth and final part is a collection of examples that demonstrate the application of the methods introduced in the first parts to problems in materials science.

Claims Procedure for Plans Providing Disability Benefits; 90-Day Delay of Applicability Date. Final rule; delay of applicability

Science.gov (United States)

2017-11-29

This document delays for ninety (90) days--through April 1, 2018--the applicability of a final rule amending the claims procedure requirements applicable to ERISA-covered employee benefit plans that provide disability benefits (Final Rule). The Final Rule was published in the Federal Register on December 19, 2016, became effective on January 18, 2017, and was scheduled to become applicable on January 1, 2018. The delay announced in this document is necessary to enable the Department of Labor to carefully consider comments and data as part of its effort, pursuant to Executive Order 13777, to examine regulatory alternatives that meet its objectives of ensuring the full and fair review of disability benefit claims while not imposing unnecessary costs and adverse consequences.

Application of local area network technology in an engineering environment

International Nuclear Information System (INIS)

Powell, A.D.; Sokolowski, M.A.

1990-01-01

This paper reports on the application of local area network technology in an engineering environment. Mobil Research and Development Corporation Engineering, Dallas, texas has installed a local area network (LAN) linking over 85 microcomputers. This network, which has been in existence for more than three years, provides common access by all engineers to quality output devices such as laser printers and multi-color pen plotters; IBM mainframe connections; electronic mail and file transfer; and common engineering program. The network has been expanded via a wide area ethernet network to link the Dallas location with a functionally equivalent LAN of over 400 microcomputers in Princeton, N.J. Additionally, engineers on assignment at remote areas in Europe, U.S., Africa and project task forces have dial-in access to the network via telephone lines

Engineering applications of fpgas chaotic systems, artificial neural networks, random number generators, and secure communication systems

CERN Document Server

Tlelo-Cuautle, Esteban; de la Fraga, Luis Gerardo

2016-01-01

This book offers readers a clear guide to implementing engineering applications with FPGAs, from the mathematical description to the hardware synthesis, including discussion of VHDL programming and co-simulation issues. Coverage includes FPGA realizations such as: chaos generators that are described from their mathematical models; artificial neural networks (ANNs) to predict chaotic time series, for which a discussion of different ANN topologies is included, with different learning techniques and activation functions; random number generators (RNGs) that are realized using different chaos generators, and discussions of their maximum Lyapunov exponent values and entropies. Finally, optimized chaotic oscillators are synchronized and realized to implement a secure communication system that processes black and white and grey-scale images. In each application, readers will find VHDL programming guidelines and computer arithmetic issues, along with co-simulation examples with Active-HDL and Simulink. Readers will b...

State of radiotracer application at the Division of Environmental Engineering, CDTN, NUCLEBRAS

International Nuclear Information System (INIS)

Aun, P.E.; Castro, J.O.N.M. de; Moreira, R.M.; Bandeira, J.V.

1984-01-01

The history and working phylosophy of the NUCLEBRAS division of environmental engineering are reported. Some aspects of tracer applications and of the tasks performed by the division of environmental engineering are described. (M.A.C.) [pt

Application of a Systems Engineering Approach to Support Space Reactor Development

International Nuclear Information System (INIS)

Wold, Scott

2005-01-01

In 1992, approximately 25 Russian and 12 U.S. engineers and technicians were involved in the transport, assembly, inspection, and testing of over 90 tons of Russian equipment associated with the Thermionic System Evaluation Test (TSET) Facility. The entire Russian Baikal Test Stand, consisting of a 5.79 m tall vacuum chamber and related support equipment, was reassembled and tested at the TSET facility in less than four months. In November 1992, the first non-nuclear operational test of a complete thermionic power reactor system in the U.S. was accomplished three months ahead of schedule and under budget. A major factor in this accomplishment was the application of a disciplined top-down systems engineering approach and application of a spiral development model to achieve the desired objectives of the TOPAZ International Program (TIP). Systems Engineering is a structured discipline that helps programs and projects conceive, develop, integrate, test and deliver products and services that meet customer requirements within cost and schedule. This paper discusses the impact of Systems Engineering and a spiral development model on the success of the TOPAZ International Program and how the application of a similar approach could help ensure the success of future space reactor development projects

Developing 3D microstructures for tissue engineering

DEFF Research Database (Denmark)

Mohanty, Soumyaranjan

casting process to generate various large scale tissue engineering constructs with single pore geometry with the desired mechanical stiffness and porosity. In addition, a new technique was developed to fa bricate dual-pore scaffolds for various tissue-engineering applications where 3D printing...... materials have been developed and tested for enhancing the differentiation of hiPSC-derived hepatocytes and fabricating biodegradable scaffolds for in-vivo tissue engineering applications. Along with various scaffolds fabrication methods we finally presented an optimized study of hepatic differentiation...... of hiPSC-derived DE cells cultured for 25 days in a 3D perfusion bioreactor system with an array of 16 small-scale tissue-bioreactors with integrated dual-pore pore scaffolds and flow rates. Hepatic differentiation and functionality of hiPSC-derived hepatocytes were successfully assessed and compared...

Applications of computational tools in biosciences and medical engineering

CERN Document Server

Altenbach, Holm

2015-01-01

 This book presents the latest developments and applications of computational tools related to the biosciences and medical engineering. It also reports the findings of different multi-disciplinary research projects, for example, from the areas of scaffolds and synthetic bones, implants and medical devices, and medical materials. It is also shown that the application of computational tools often requires mathematical and experimental methods. Computational tools such as the finite element methods, computer-aided design and optimization as well as visualization techniques such as computed axial tomography open up completely new research fields that combine the fields of engineering and bio/medical. Nevertheless, there are still hurdles since both directions are based on quite different ways of education. Often even the “language” can vary from discipline to discipline.

Design engineer perceptions and attitudes regarding human factors application to nuclear power plant design

International Nuclear Information System (INIS)

Ma, R.; Jones, J. M.

2006-01-01

With the renewed interest in nuclear power and the possibility of constructing new reactors within the next decade in the U.S., there are several challenges for the regulators, designers, and vendors. One challenge is to ensure that Human Factors Engineering (HFE) is involved, and correctly applied in the life-cycle design of the Nuclear Power Plant (NPP). As an important part of the effort, people would ask: 'is the system-design engineer effectively incorporating HFE in the NPPs design?' The present study examines the sagacity of Instrumentation and Control design engineers on issues relating to awareness, attitude, and application of HFE in NPP design. A questionnaire was developed and distributed, focusing on the perceptions and attitudes of the design engineers. The responses revealed that, while the participants had a relatively high positive attitude about HFE, their awareness and application of HFE were moderate. The results also showed that senior engineers applied HFE more frequently in their design work than young engineers. This study provides some preliminary results and implications for improved HFE education and application in NPP design. (authors)

Application of Formal Methods in Software Engineering

Directory of Open Access Journals (Sweden)

Adriana Morales

2011-12-01

Full Text Available The purpose of this research work is to examine: (1 why are necessary the formal methods for software systems today, (2 high integrity systems through the methodology C-by-C –Correctness-by-Construction–, and (3 an affordable methodology to apply formal methods in software engineering. The research process included reviews of the literature through Internet, in publications and presentations in events. Among the Research results found that: (1 there is increasing the dependence that the nations have, the companies and people of software systems, (2 there is growing demand for software Engineering to increase social trust in the software systems, (3 exist methodologies, as C-by-C, that can provide that level of trust, (4 Formal Methods constitute a principle of computer science that can be applied software engineering to perform reliable process in software development, (5 software users have the responsibility to demand reliable software products, and (6 software engineers have the responsibility to develop reliable software products. Furthermore, it is concluded that: (1 it takes more research to identify and analyze other methodologies and tools that provide process to apply the Formal Software Engineering methods, (2 Formal Methods provide an unprecedented ability to increase the trust in the exactitude of the software products and (3 by development of new methodologies and tools is being achieved costs are not more a disadvantage for application of formal methods.

Advantages and Disadvantages of Using MATLAB/ode45 for Solving Differential Equations in Engineering Applications

OpenAIRE

Waleed K. Ahmed

2013-01-01

The present paper demonstrates the route used for solving differential equations for the engineering applications at UAEU. Usually students at the Engineering Requirements Unit (ERU) stage of the Faculty of Engineering at the UAEU must enroll in a course of Differential Equations and Engineering Applications (MATH 2210) as a prerequisite for the subsequent stages of their study. Mainly, one of the objectives of this course is that the students practice MATLAB software package during the cours...

Engineered nonviral nanocarriers for intracellular gene delivery applications

International Nuclear Information System (INIS)

Ojea-Jiménez, Isaac; Puntes, Victor F; Tort, Olivia; Lorenzo, Julia

2012-01-01

The efficient delivery of nucleic acids into mammalian cells is a central aspect of cell biology and of medical applications, including cancer therapy and tissue engineering. Non-viral chemical methods have been received with great interest for transfecting cells. However, further development of nanocarriers that are biocompatible, efficient and suitable for clinical applications is still required. In this paper, the different material platforms for gene delivery are comparatively addressed, and the mechanisms of interaction with biological systems are discussed carefully. (paper)

Applications of Green's functions in science and engineering

CERN Document Server

Greenberg, Michael D

2015-01-01

Concise and highly regarded, this treatment of Green's functions and their applications in science and engineering is geared toward undergraduate and graduate students with only a moderate background in ordinary differential equations and partial differential equations. The text also includes a wealth of information of a more general nature on boundary value problems, generalized functions, eigenfunction expansions, partial differential equations, and acoustics. The two-part treatment begins with an overview of applications to ordinary differential equations. Topics include the adjoint operato

Applications of Ecological Engineering Remedies for Uranium Processing Sites, USA

Energy Technology Data Exchange (ETDEWEB)

Waugh, William [Navarro Research and Engineering

2016-05-23

The U.S. Department of Energy (USDOE) is responsible for remediation of environmental contamination and long-term stewardship of sites associated with the legacy of nuclear weapons production during the Cold War in the United States. Protection of human health and the environment will be required for hundreds or even thousands of years at many legacy sites. USDOE continually evaluates and applies advances in science and technology to improve the effectiveness and sustainability of surface and groundwater remedies (USDOE 2011). This paper is a synopsis of ecological engineering applications that USDOE is evaluating to assess the effectiveness of remedies at former uranium processing sites in the southwestern United States. Ecological engineering remedies are predicated on the concept that natural ecological processes at legacy sites, once understood, can be beneficially enhanced or manipulated. Advances in tools for characterizing key processes and for monitoring remedy performance are demonstrating potential. We present test cases for four ecological engineering remedies that may be candidates for international applications.

Application of particle swarm optimization in gas turbine engine fuel controller gain tuning

Science.gov (United States)

Montazeri-Gh, M.; Jafari, S.; Ilkhani, M. R.

2012-02-01

This article presents the application of particle swarm optimization (PSO) for gain tuning of the gas turbine engine (GTE) fuel controller. For this purpose, the structure of a fuel controller is firstly designed based on the GTE control requirements and constraints. The controller gains are then tuned by PSO where the tuning process is formulated as an engineering optimization problem. In this study, the response time during engine acceleration and deceleration as well as the engine fuel consumption are considered as the objective functions. A computer simulation is also developed to evaluate the objective values for a single spool GTE. The GTE model employed for the simulation is a Wiener model, the parameters of which are extracted from experimental tests. In addition, the effect of neighbour acceleration on PSO results is studied. The results show that the neighbour acceleration factor has a considerable effect on the convergence rate of the PSO process. The PSO results are also compared with the results obtained through a genetic algorithm (GA) to show the relative merits of PSO. Moreover, the PSO results are compared with the results obtained from the dynamic programming (DP) method in order to illustrate the ability of proposed method in finding the global optimal solution. Furthermore, the objective function is also defined in multi-objective manner and the multi-objective particle swarm optimization (MOPSO) is applied to find the Pareto-front for the problem. Finally, the results obtained from the simulation of the optimized controller confirm the effectiveness of the proposed approach to design an optimal fuel controller resulting in an improved GTE performance as well as protection against the physical limitations.

Gas Turbine Engine Starting Applicated on TV2-117 Turboshaft

Directory of Open Access Journals (Sweden)

R. M. Catana

2017-10-01

Full Text Available The paper presents the examination of two different types of engine starting configurations, applicated on TV2-117A turboshaft, running into the test bench. The first type of starting configuration is a normal starting, with the engine connected to the dynamometer which controls the free turbine speed by the dynamometer load. The second type of starting is a different one, the engine is not connected with the dynamometer, therefore it results that there is no control of the free turbine speed from the dynamometer, only from the engine but in particular conditions. To achieve the starting phase an instrumentation scheme is created, to control and monitor the engine, and a starting sequence with all the parameters, confirmations and commands that are involved into the starting phase. The engine starting is performed by the test bench operating system, composed of an acquisition system and a programmable controller, wherewith is running the starting sequence.

Pulmonary applications and toxicity of engineered nanoparticles

OpenAIRE

Card, Jeffrey W.; Zeldin, Darryl C.; Bonner, James C.; Nestmann, Earle R.

2008-01-01

Because of their unique physicochemical properties, engineered nanoparticles have the potential to significantly impact respiratory research and medicine by means of improving imaging capability and drug delivery, among other applications. These same properties, however, present potential safety concerns, and there is accumulating evidence to suggest that nanoparticles may exert adverse effects on pulmonary structure and function. The respiratory system is susceptible to injury resulting from...

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications.

Science.gov (United States)

Han, Ya-Hui; Kankala, Ranjith Kumar; Wang, Shi-Bin; Chen, Ai-Zheng

2018-05-24

In recent times, photo-induced therapeutics have attracted enormous interest from researchers due to such attractive properties as preferential localization, excellent tissue penetration, high therapeutic efficacy, and minimal invasiveness, among others. Numerous photosensitizers have been considered in combination with light to realize significant progress in therapeutics. Along this line, indocyanine green (ICG), a Food and Drug Administration (FDA)-approved near-infrared (NIR, >750 nm) fluorescent dye, has been utilized in various biomedical applications such as drug delivery, imaging, and diagnosis, due to its attractive physicochemical properties, high sensitivity, and better imaging view field. However, ICG still suffers from certain limitations for its utilization as a molecular imaging probe in vivo, such as concentration-dependent aggregation, poor in vitro aqueous stability and photodegradation due to various physicochemical attributes. To overcome these limitations, much research has been dedicated to engineering numerous multifunctional polymeric composites for potential biomedical applications. In this review, we aim to discuss ICG-encapsulated polymeric nanoconstructs, which are of particular interest in various biomedical applications. First, we emphasize some attractive properties of ICG (including physicochemical characteristics, optical properties, metabolic features, and other aspects) and some of its current limitations. Next, we aim to provide a comprehensive overview highlighting recent reports on various polymeric nanoparticles that carry ICG for light-induced therapeutics with a set of examples. Finally, we summarize with perspectives highlighting the significant outcome, and current challenges of these nanocomposites.

Grouting applications in civil engineering. Volume I and II

International Nuclear Information System (INIS)

Einstein, H.H.; Barvenik, M.J.

1975-01-01

A comprehensive description of grouting applications in civil engineering is presented that can serve as a basis for the selection of grouting methods in the borehole sealing problem. The breadth and depth of the study was assured by conducting the main part of the review, the collection and evaluation of information, without specifically considering the borehole sealing problem (but naturally incorporating any aspect of civil engineering applications that could be of potential use). Grouting is very much an art and not a science. In most cases, it is a trial and error procedure where an inexpensive method is initially tried and then a more expensive one is used until the desired results are obtained. Once a desired effect is obtained, it is difficult to credit any one procedure with the success because the results are due to the summation of all the methods used. In many cases, the method that proves successful reflects a small abnormality in the ground or structure rather than its overall characteristics. Hence, successful grouting relies heavily on good engineering judgement and experience, and not on a basic set of standard correlations or equations. 800 references

Applicability of advanced automotive heat engines to solar thermal power

Science.gov (United States)

Beremand, D. G.; Evans, D. G.; Alger, D. L.

The requirements of a solar thermal power system are reviewed and compared with the predicted characteristics of automobile engines under development. A good match is found in terms of power level and efficiency when the automobile engines, designed for maximum powers of 65-100 kW (87 to 133 hp) are operated to the nominal 20-40 kW electric output requirement of the solar thermal application. At these reduced power levels it appears that the automotive gas turbine and Stirling engines have the potential to deliver the 40+ percent efficiency goal of the solar thermal program.

Paraffin-based hybrid rocket engines applications: A review and a market perspective

Science.gov (United States)

Mazzetti, Alessandro; Merotto, Laura; Pinarello, Giordano

2016-09-01

Hybrid propulsion technology for aerospace applications has received growing attention in recent years due to its important advantages over competitive solutions. Hybrid rocket engines have a great potential for several aeronautics and aerospace applications because of their safety, reliability, low cost and high performance. As a consequence, this propulsion technology is feasible for a number of innovative missions, including space tourism. On the other hand, hybrid rocket propulsion's main drawback, i.e. the difficulty in reaching high regression rate values using standard fuels, has so far limited the maturity level of this technology. The complex physico-chemical processes involved in hybrid rocket engines combustion are of major importance for engine performance prediction and control. Therefore, further investigation is ongoing in order to achieve a more complete understanding of such phenomena. It is well known that one of the most promising solutions for overcoming hybrid rocket engines performance limits is the use of liquefying fuels. Such fuels can lead to notably increased solid fuel regression rate due to the so-called "entrainment phenomenon". Among liquefying fuels, paraffin-based formulations have great potentials as solid fuels due to their low cost, availability (as they can be derived from industrial waste), low environmental impact and high performance. Despite the vast amount of literature available on this subject, a precise focus on market potential of paraffins for hybrid propulsion aerospace applications is lacking. In this work a review of hybrid rocket engines state of the art was performed, together with a detailed analysis of the possible applications of such a technology. A market study was carried out in order to define the near-future foreseeable development needs for hybrid technology application to the aforementioned missions. Paraffin-based fuels are taken into account as the most promising segment for market development

Artificial neural network applications in the calibration of spark-ignition engines: An overview

Directory of Open Access Journals (Sweden)

Richard Fiifi Turkson

2016-09-01

Full Text Available Emission legislation has become progressively tighter, making the development of new internal combustion engines very challenging. New engine technologies for complying with these regulations introduce an exponential dependency between the number of test combinations required for obtaining optimum results and the time and cost outlays. This makes the calibration task very expensive and virtually impossible to carry out. The potential use of trained neural networks in combination with Design of Experiments (DoE methods for engine calibration has been a subject of research activities in recent times. This is because artificial neural networks, compared with other data-driven modeling techniques, perform better in satisfying a majority of the modeling requirements for engine calibration including the curse of dimensionality; the use of DoE for obtaining few measurements as practicable, with the aim of reducing engine calibration costs; the required flexibility that allows model parameters to be optimized to avoid overfitting; and the facilitation of automated online optimization during the engine calibration process that eliminates the need for user intervention. The purpose of this review is to give an overview of the various applications of neural networks in the calibration of spark-ignition engines. The identified and discussed applications include system identification for rapid prototyping, virtual sensing, use of neural networks as look-up table surrogates, emerging control strategies and On-Board Diagnostic (OBD applications. The demerits of neural networks, future possibilities and alternatives were also discussed.

Penerapan Reverse Engineering Dalam Penentuan Pola Interaksi Sequence Diagram Pada Sampel Aplikasi Android

Directory of Open Access Journals (Sweden)

Vierdy Sulfianto Rahmadani

2015-04-01

Full Text Available The purpose of this research is to apply the application of reverse engineering to determine interaction patterns of the Sequence diagram that can be used by system analysts as a template for designing UML sequence diagrams. Sample applications from android are used as dataset for reverse engineering and pattern identification. The first step is collecting application datasets. The next stage is identifying the features and applications activity, reverse engineering to obtain a sequence diagram model, and then synthesize all of the models into an interaction pattern of sequence diagram. The final step is to test the patterns by implementing it in an application development case stud. The evaluation results concludes that interaction patterns of sequence diagram designs obtained in reverse engineering steps is able to be implemented in software development that contained similar features with the obtained features in this research.

Advanced Artificial Science. The development of an artificial science and engineering research infrastructure to facilitate innovative computational modeling, analysis, and application to interdisciplinary areas of scientific investigation.

Energy Technology Data Exchange (ETDEWEB)

Saffer, Shelley (Sam) I.

2014-12-01

This is a final report of the DOE award DE-SC0001132, Advanced Artificial Science. The development of an artificial science and engineering research infrastructure to facilitate innovative computational modeling, analysis, and application to interdisciplinary areas of scientific investigation. This document describes the achievements of the goals, and resulting research made possible by this award.

Biocompatibility of hydrogel-based scaffolds for tissue engineering applications.

Science.gov (United States)

Naahidi, Sheva; Jafari, Mousa; Logan, Megan; Wang, Yujie; Yuan, Yongfang; Bae, Hojae; Dixon, Brian; Chen, P

2017-09-01

Recently, understanding of the extracellular matrix (ECM) has expanded rapidly due to the accessibility of cellular and molecular techniques and the growing potential and value for hydrogels in tissue engineering. The fabrication of hydrogel-based cellular scaffolds for the generation of bioengineered tissues has been based on knowledge of the composition and structure of ECM. Attempts at recreating ECM have used either naturally-derived ECM components or synthetic polymers with structural integrity derived from hydrogels. Due to their increasing use, their biocompatibility has been questioned since the use of these biomaterials needs to be effective and safe. It is not surprising then that the evaluation of biocompatibility of these types of biomaterials for regenerative and tissue engineering applications has been expanded from being primarily investigated in a laboratory setting to being applied in the multi-billion dollar medicinal industry. This review will aid in the improvement of design of non-invasive, smart hydrogels that can be utilized for tissue engineering and other biomedical applications. In this review, the biocompatibility of hydrogels and design criteria for fabricating effective scaffolds are examined. Examples of natural and synthetic hydrogels, their biocompatibility and use in tissue engineering are discussed. The merits and clinical complications of hydrogel scaffold use are also reviewed. The article concludes with a future outlook of the field of biocompatibility within the context of hydrogel-based scaffolds. Copyright © 2017 Elsevier Inc. All rights reserved.

Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications.

Science.gov (United States)

Vedadghavami, Armin; Minooei, Farnaz; Mohammadi, Mohammad Hossein; Khetani, Sultan; Rezaei Kolahchi, Ahmad; Mashayekhan, Shohreh; Sanati-Nezhad, Amir

2017-10-15

Hydrogels have been recognized as crucial biomaterials in the field of tissue engineering, regenerative medicine, and drug delivery applications due to their specific characteristics. These biomaterials benefit from retaining a large amount of water, effective mass transfer, similarity to natural tissues and the ability to form different shapes. However, having relatively poor mechanical properties is a limiting factor associated with hydrogel biomaterials. Controlling the biomechanical properties of hydrogels is of paramount importance. In this work, firstly, mechanical characteristics of hydrogels and methods employed for characterizing these properties are explored. Subsequently, the most common approaches used for tuning mechanical properties of hydrogels including but are not limited to, interpenetrating polymer networks, nanocomposites, self-assembly techniques, and co-polymerization are discussed. The performance of different techniques used for tuning biomechanical properties of hydrogels is further compared. Such techniques involve lithography techniques for replication of tissues with complex mechanical profiles; microfluidic techniques applicable for generating gradients of mechanical properties in hydrogel biomaterials for engineering complex human tissues like intervertebral discs, osteochondral tissues, blood vessels and skin layers; and electrospinning techniques for synthesis of hybrid hydrogels and highly ordered fibers with tunable mechanical and biological properties. We finally discuss future perspectives and challenges for controlling biomimetic hydrogel materials possessing proper biomechanical properties. Hydrogels biomaterials are essential constituting components of engineered tissues with the applications in regenerative medicine and drug delivery. The mechanical properties of hydrogels play crucial roles in regulating the interactions between cells and extracellular matrix and directing the cells phenotype and genotype. Despite

Heavy Truck Engine Program

Energy Technology Data Exchange (ETDEWEB)

Nelson, Christopher

2009-01-08

The Heavy Duty Truck Engine Program at Cummins embodied three significant development phases. All phases of work strove to demonstrate a high level of diesel engine efficiency in the face of increasingly stringent emission requirements. Concurrently, aftertreatment system development and refinement was pursued in support of these efficiency demonstrations. The program's first phase focused on the demonstration in-vehicle of a high level of heavy duty diesel engine efficiency (45% Brake Thermal Efficiency) at a typical cruise condition while achieving composite emissions results which met the 2004 U.S. EPA legislated standards. With a combination of engine combustion calibration tuning and the development and application of Urea-based SCR and particulate aftertreatment, these demonstrations were successfully performed by Q4 of 2002. The second phase of the program directed efforts towards an in-vehicle demonstration of an engine system capable of meeting 2007 U.S. EPA legislated emissions requirements while achieving 45% Brake Thermal Efficiency at cruise conditions. Through further combustion optimization, the refinement of Cummins Cooled EGR architecture, the application of a high pressure common rail fuel system and the incorporation of optimized engine parasitics, Cummins Inc. successfully demonstrated these deliverables in Q2 of 2004. The program's final phase set a stretch goal of demonstrating 50% Brake Thermal Efficiency from a heavy duty diesel engine system capable of meeting 2010 U.S. EPA legislated emissions requirements. Cummins chose to pursue this goal through further combustion development and refinement of the Cooled EGR system architecture and also applied a Rankine cycle Waste Heat Recovery technique to convert otherwise wasted thermal energy to useful power. The engine and heat recovery system was demonstrated to achieve 50% Brake Thermal Efficiency while operating at a torque peak condition in second quarter, 2006. The 50% efficient

Introduction to the application of genetic algorithms in engineering

Directory of Open Access Journals (Sweden)

I. S. Shaw

1998-07-01

Full Text Available Genetic algorithms constitute a new research area in the field of artificial intelligence. This work is aimed at their application in specific areas of engineering where good results have already been achieved. The purpose of this work is to provide a basic introduction for students as well as experienced engineers who wish to upgrade their knowledge. A distinctive feature of artificial intelligence is that instead of mathematical models, either direct human experience or certain functions of the human brain for the modelling of physical phenomena are used.

Engineering artificial machines from designable DNA materials for biomedical applications.

Science.gov (United States)

Qi, Hao; Huang, Guoyou; Han, Yulong; Zhang, Xiaohui; Li, Yuhui; Pingguan-Murphy, Belinda; Lu, Tian Jian; Xu, Feng; Wang, Lin

2015-06-01

Deoxyribonucleic acid (DNA) emerges as building bricks for the fabrication of nanostructure with complete artificial architecture and geometry. The amazing ability of DNA in building two- and three-dimensional structures raises the possibility of developing smart nanomachines with versatile controllability for various applications. Here, we overviewed the recent progresses in engineering DNA machines for specific bioengineering and biomedical applications.

76 FR 10213 - Special Conditions: Embraer Model EMB-135BJ (Legacy 650) Airplanes, Limit Engine Torque Loads for...

Science.gov (United States)

2011-02-24

... Torque Loads for Sudden Engine Stoppage AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final... torque load imposed by sudden engine-stoppage conditions. The applicable airworthiness regulations do not... incorporate novel or unusual design features involving engine size and the potential torque load imposed by...

Photonics applications and web engineering: WILGA Summer 2016

Science.gov (United States)

Romaniuk, Ryszard S.

2016-09-01

Wilga Summer 2016 Symposium on Photonics Applications and Web Engineering was held on 29 May - 06 June. The Symposium gathered over 350 participants, mainly young researchers active in optics, optoelectronics, photonics, electronics technologies and applications. There were presented around 300 presentations in a few main topical tracks including: bio-photonics, optical sensory networks, photonics-electronics-mechatronics co-design and integration, large functional system design and maintenance, Internet of Thins, and other. The paper is an introduction the 2016 WILGA Summer Symposium Proceedings, and digests some of the Symposium chosen key presentations.

Photonics applications and web engineering: WILGA Summer 2015

Science.gov (United States)

Romaniuk, Ryszard S.

2015-09-01

Wilga Summer 2015 Symposium on Photonics Applications and Web Engineering was held on 23-31 May. The Symposium gathered over 350 participants, mainly young researchers active in optics, optoelectronics, photonics, electronics technologies and applications. There were presented around 300 presentations in a few main topical tracks including: bio-photonics, optical sensory networks, photonics-electronics-mechatronics co-design and integration, large functional system design and maintenance, Internet of Thins, and other. The paper is an introduction the 2015 WILGA Summer Symposium Proceedings, and digests some of the Symposium chosen key presentations.

Electromechanical properties of superconductors for DOE/OFE applications. Final report

International Nuclear Information System (INIS)

Ekin, J.W.; Bray, S.L.

1998-01-01

In many superconductor applications, especially large magnets, the superconductor is required to perform while under the influence of strong mechanical forces. These forces are commonly due to residual fabrication stress, differential thermal contraction of dissimilar materials, and electromagnetic forces generated within an energized magnet coil. Thorough knowledge of a superconductor's electrical performance under the influence of these forces (electromechanical properties) is required for successful magnet engineering. This report presents results of research conducted during the period from august 1993 through March 1997 on the electromechanical properties of superconductors for DOE/OFE fusion applications

15 CFR 301.7 - Final disposition of an application.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Final disposition of an application. 301.7 Section 301.7 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS INSTRUMENTS...

CAD/CAM/CAI Application for High-Precision Machining of Internal Combustion Engine Pistons

Directory of Open Access Journals (Sweden)

V. V. Postnov

2014-07-01

Full Text Available CAD/CAM/CAI application solutions for internal combustion engine pistons machining was analyzed. Low-volume technology of internal combustion engine pistons production was proposed. Fixture for CNC turning center was designed.

Sandia National Laboratories ASCI Applications Software Quality Engineering Practices; TOPICAL

International Nuclear Information System (INIS)

ZEPPER, JOHN D.; ARAGON, KATHRYN MARY; ELLIS, MOLLY A.; BYLE, KATHLEEN A.; EATON, DONNA SUE

2002-01-01

This document provides a guide to the deployment of the software verification activities, software engineering practices, and project management principles that guide the development of Accelerated Strategic Computing Initiative (ASCI) applications software at Sandia National Laboratories (Sandia). The goal of this document is to identify practices and activities that will foster the development of reliable and trusted products produced by the ASCI Applications program. Document contents include an explanation of the structure and purpose of the ASCI Quality Management Council, an overview of the software development lifecycle, an outline of the practices and activities that should be followed, and an assessment tool. These sections map practices and activities at Sandia to the ASCI Software Quality Engineering: Goals, Principles, and Guidelines, a Department of Energy document

Developing games with Magic Playground: a gesture-based game engine

OpenAIRE

Dehanov, Juana; Dias, José Miguel Salles; Bastos, Rafael; Cabral, Carolina

2005-01-01

ACE 134 This paper presents Magic Playground, a game engine that enables the development of entertainment applications with realtime gesture-based Human-Computer Interaction (HCI). We describe the main architectural elements of our system and provide a guideline on how to program the engine in order to create games. Finally, we present usability evaluation results of a game, which emulates the known Tetris game1.

The Application of V&V within Reuse-Based Software Engineering

Science.gov (United States)

Addy, Edward

1996-01-01

Verification and Validation (V&V) is performed during application development for many systems, especially safety-critical and mission-critical systems. The V&V process is intended to discover errors as early as possible during the development process. Early discovery is important in order to minimize the cost and other impacts of correcting these errors. In reuse-based software engineering, decisions on the requirements, design and even implementation of domain assets can can be made prior to beginning development of a specific system. in order to bring the effectiveness of V&V to bear within reuse-based software engineering. V&V must be incorporated within the domain engineering process.

Electronics Engineering Research. Final report, FY 1979

International Nuclear Information System (INIS)

Weissenberger, S.

1980-01-01

Accomplishments in Electronics Engineering Research (EER) during FY79 spanned a broad range of technologies, from high-speed microelectronics to digital image enhancement; from underground probing with electromagnetic waves to detecting neutrons with a small solid-state device; and from computer systems to aid engineers, to software tools to aid programmers. This report describes the overall EER program and its objectives, summarizes progress made in FY79, and outlines plans for FY80

Council of Energy Engineering Research. Final Report

Energy Technology Data Exchange (ETDEWEB)

Goldstein, Richard J.

2003-08-22

The Engineering Research Program, a component program of the DOE Office of Basic Energy Sciences (BES), was established in 1979 to aid in resolving the numerous engineering issues arising from efforts to meet U.S. energy needs. The major product of the program became part of the body of knowledge and data upon which the applied energy technologies are founded; the product is knowledge relevant to energy exploration, production, conversion and use.

Complex Adaptive System of Systems (CASoS) Engineering Applications. Version 1.0.

Energy Technology Data Exchange (ETDEWEB)

Linebarger, John Michael; Maffitt, S. Louise (New Mexico Institute of Mining and Technology, Albuquerque, NM); Glass, Robert John, Jr.; Beyeler, Walter Eugene; Brown, Theresa Jean; Ames, Arlo Leroy

2011-10-01

Complex Adaptive Systems of Systems, or CASoS, are vastly complex eco-socio-economic-technical systems which we must understand to design a secure future for the nation and the world. Perturbations/disruptions in CASoS have the potential for far-reaching effects due to highly-saturated interdependencies and allied vulnerabilities to cascades in associated systems. The Phoenix initiative approaches this high-impact problem space as engineers, devising interventions (problem solutions) that influence CASoS to achieve specific aspirations. CASoS embody the world's biggest problems and greatest opportunities: applications to real world problems are the driving force of our effort. We are developing engineering theory and practice together to create a discipline that is grounded in reality, extends our understanding of how CASoS behave, and allows us to better control those behaviors. Through application to real-world problems, Phoenix is evolving CASoS Engineering principles while growing a community of practice and the CASoS engineers to populate it.

3rd International Conference on Advanced Engineering : Theory and Applications 2016

CERN Document Server

Dao, Tran; Kim, Sang; Tien, Nguyen; Zelinka, Ivan

2017-01-01

These lecture notes present selected topics concerning a wide range of electrical and electronics applications, highlighting innovative approaches and offering state-of-the-art overviews. The book is divided into 14 topical areas, including e.g. telecommunication, power systems, robotics, control systems, renewable energy, mechanical engineering, computer science and more. Readers will find revealing papers on the design and implementation of control algorithms for automobiles and electrohydraulic systems, efficient protocols for vehicular ad hoc networks and motor control, and energy-saving methods that can be applied in various fields of electrical engineering. The book offers a valuable resource for all practitioners who want to apply the topics discussed to solve real-world problems in their challenging applications. Offering insights into common and related subjects in the research fields of modern electrical, electronic and related technologies, it will also benefit all scientists and engineers working ...

Recent advances in engineering microparticles and their nascent utilization in biomedical delivery and diagnostic applications.

Science.gov (United States)

Choi, Andrew; Seo, Kyoung Duck; Kim, Do Wan; Kim, Bum Chang; Kim, Dong Sung

2017-02-14

Complex microparticles (MPs) bearing unique characteristics such as well-tailored sizes, various morphologies, and multi-compartments have been attempted to be produced by many researchers in the past decades. However, a conventionally used method of fabricating MPs, emulsion polymerization, has a limitation in achieving the aforementioned characteristics and several approaches such as the microfluidics-assisted (droplet-based microfluidics and flow lithography-based microfluidics), electrohydrodynamics (EHD)-based, centrifugation-based, and template-based methods have been recently suggested to overcome this limitation. The outstanding features of complex MPs engineered through these suggested methods have provided new opportunities for MPs to be applied in a wider range of applications including cell carriers, drug delivery agents, active pigments for display, microsensors, interface stabilizers, and catalyst substrates. Overall, the engineered MPs expose their potential particularly in the field of biomedical engineering as the increased complexity in the engineered MPs fulfills well the requirements of the high-end applications. This review outlines the current trends of newly developed techniques used for engineered MPs fabrication and focuses on the current state of engineered MPs in biomedical applications.

Application of wireless monitoring and communication systems in the power engineering

Directory of Open Access Journals (Sweden)

Grechikhin V. A.

2012-06-01

Full Text Available The article describes some achievements of modern radio electronics, which prove a huge potential of modern wireless engineering for using in the fuel-energy complex. Wireless corporation communication systems, application of short-range radar measuring systems on the power engineering objects, prospects of laser measuring systems, methods of radio thermography and radio spectroscopy, wireless acoustic-electronic sensors are discussed.

Analytical and experimental evaluation of joining silicon nitride to metal and silicon carbide to metal for advanced heat engine applications. Final report

Energy Technology Data Exchange (ETDEWEB)

Kang, S.; Selverian, J.H.; O`Neil, D.; Kim, H. [GTE Labs., Inc., Waltham, MA (US); Kim, K. [Brown Univ., Providence, RI (US). Div. of Engineering

1993-05-01

This report summarizes the results of Phase 2 of Analytical and Experimental Evaluation of Joining Silicon Nitride to Metal and Silicon Carbide to Metal for Advanced Heat Engine Applications. A general methodology was developed to optimize the joint geometry and material systems for 650{degrees}C applications. Failure criteria were derived to predict the fracture of the braze and ceramic. Extensive finite element analyses (FEA) were performed to examine various joint geometries and to evaluate the affect of different interlayers on the residual stress state. Also, material systems composed of coating materials, interlayers, and braze alloys were developed for the program based on the chemical stability and strength of the joints during processing, and service. The FEA results were compared with experiments using two methods: (1) an idealized strength relationship of the ceramic, and (2) a probabilistic analysis of the ceramic strength (NASA CARES). The results showed that the measured strength of the joint reached 30--80% of the strength predicted by FEA. Also, potential high-temperature braze alloys were developed and evaluated for the high-temperature application of ceramic-metal joints. 38 tabs, 29 figs, 20 refs.

Engineering thermal engine rocket adventurer for space nuclear application

International Nuclear Information System (INIS)

Nam, Seung H.; Suh, Kune Y.; Kang, Seong G.

2008-01-01

The conceptual design for the first-of-a-kind engineering of Thermal Engine Rocket Adventure (TERA) is described. TERA comprising the Battery Omnibus Reactor Integral System (BORIS) as the heat resource and the Space Propulsion Reactor Integral System (SPRIS) as the propulsion system, is one of the advanced Nuclear Thermal Rocket (NTR) engine utilizing hydrogen (H 2 ) propellant being developed at present time. BORIS in this application is an open cycle high temperature gas cooled reactor that has eighteen fuel elements for propulsion and one fuel element for electricity generation and propellant pumping. Each fuel element for propulsion has its own small nozzle. The nineteen fuel elements are arranged into hexagonal prism shape in the core and surrounded by outer Be reflector. The TERA maximum power is 1,000 MW th , specific impulse 1,000 s, thrust 250,000 N, and the total mass is 550 kg including the reactor, turbo pump and auxiliaries. Each fuel element comprises the fuel assembly, moderators, pressure tube and small nozzle. The TERA fuel assembly is fabricated of 93% enriched 1.5 mm (U, Zr, Nb)C wafers in 25.3% voided Square Lattice Honeycomb (SLHC). The H 2 propellant passes through these flow channels. This study is concerned with thermohydrodynamic analysis of the fuel element for propulsion with hypothetical axial power distribution because nuclear analysis of TERA has not been performed yet. As a result, when the power distribution of INSPI's M-SLHC is applied to the fuel assembly, the local heat concentration of fuel is more serious and the pressure of the initial inlet H 2 is higher than those of constant average power distribution applied. This means the fuel assembly geometry of 1.5 mm fuel wafers and 25.3% voided SLHC needs to be changed in order to reduce thermal and mechanical shocks. (author)

Chitosan for gene delivery and orthopedic tissue engineering applications.

Science.gov (United States)

Raftery, Rosanne; O'Brien, Fergal J; Cryan, Sally-Ann

2013-05-15

Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated with viral and synthetic non-viral gene delivery approaches. One natural polymer which has generated interest as a gene delivery vector is chitosan. Chitosan is biodegradable, biocompatible and non-toxic. Much of the appeal of chitosan is due to the presence of primary amine groups in its repeating units which become protonated in acidic conditions. This property makes it a promising candidate for non-viral gene delivery. Chitosan-based vectors have been shown to transfect a number of cell types including human embryonic kidney cells (HEK293) and human cervical cancer cells (HeLa). Aside from its use in gene delivery, chitosan possesses a range of properties that show promise in tissue engineering applications; it is biodegradable, biocompatible, has anti-bacterial activity, and, its cationic nature allows for electrostatic interaction with glycosaminoglycans and other proteoglycans. It can be used to make nano- and microparticles, sponges, gels, membranes and porous scaffolds. Chitosan has also been shown to enhance mineral deposition during osteogenic differentiation of MSCs in vitro. The purpose of this review is to critically discuss the use of chitosan as a gene delivery vector with emphasis on its application in orthopedic tissue engineering.

Engineering Application Way of Faults Knowledge Discovery Based on Rough Set Theory

International Nuclear Information System (INIS)

Zhao Rongzhen; Deng Linfeng; Li Chao

2011-01-01

For the knowledge acquisition puzzle of intelligence decision-making technology in mechanical industry, to use the Rough Set Theory (RST) as a kind of tool to solve the puzzle was researched. And the way to realize the knowledge discovery in engineering application is explored. A case extracting out the knowledge rules from a concise data table shows out some important information. It is that the knowledge discovery similar to the mechanical faults diagnosis is an item of complicated system engineering project. In where, first of all-important tasks is to preserve the faults knowledge into a table with data mode. And the data must be derived from the plant site and should also be as concise as possible. On the basis of the faults knowledge data obtained so, the methods and algorithms to process the data and extract the knowledge rules from them by means of RST can be processed only. The conclusion is that the faults knowledge discovery by the way is a process of rising upward. But to develop the advanced faults diagnosis technology by the way is a large-scale knowledge engineering project for long time. Every step in which should be designed seriously according to the tool's demands firstly. This is the basic guarantees to make the knowledge rules obtained have the values of engineering application and the studies have scientific significance. So, a general framework is designed for engineering application to go along the route developing the faults knowledge discovery technology.

Lead-free bearing alloys for engine applications

Science.gov (United States)

Ratke, Lorenz; Ågren, John; Ludwig, Andreas; Tonn, Babette; Gránásy, László; Mathiesen, Ragnvald; Arnberg, Lars; Anger, Gerd; Reifenhäuser, Bernd; Lauer, Michael; Garen, Rune; Gust, Edgar

2005-10-01

Recent developments to reduce the fuel consumption, emission and air pollution, size and weight of engines for automotive, truck, ship propulsion and electrical power generation lead to temperature and load conditions within the engines that cannot be borne by conventional bearings. Presently, only costly multilayer bearings with electroplated or sputtered surface coatings can cope with the load/speed combinations required. Ecological considerations in recent years led to a ban by the European Commission on the use of lead in cars a problem for the standard bronze-lead bearing material. This MAP project is therefore developing an aluminium-based lead-free bearing material with sufficient hardness, wear and friction properties and good corrosion resistance. Only alloys made of components immiscible in the molten state can meet the demanding requirements. Space experimentation plays a crucial role in optimising the cast microstructure for such applications.

Real cases study through computer applications for futures Agricultural Engineers

Science.gov (United States)

Moratiel, R.; Durán, J. M.; Tarquis, A. M.

2010-05-01

One of the huge concerns on the higher engineer education is the lag of real cases study that the future professionals need in the work and corporation market. This concern was reflected in Bologna higher education system including recommendations in this respect. The knowhow as why this or other methodology is one of the keys to resolve this problem. In the last courses given in Department of Crop Production, at the Agronomy Engineer School of Madrid (Escuela Técnica Superior de Ingenieros Agrónomos, UPM) we have developed more than one hundred applications in Microsoft Excel®. Our aim was to show different real scenarios which the future Agronomic Engineers can be found in their professional life and with items related to crop production field. In order to achieve our target, each application in Excel presents a file text in which is explained the theoretical concepts and the objectives, as well as some resources used from Excel syntax. In this way, the student can understand and use of such application, even they can modify and customize it for a real case presented in their context and/or master project. This electronic monograph gives an answer to the need to manage data in several real scenarios showed in lectures, calculus resolution, information analysis and manage worksheets in a professional and student level.

Plant cell engineering: current research, application and future prospects

International Nuclear Information System (INIS)

Wang Xunqing; Liu Luxiang

2008-01-01

This paper reviewed the current status of basic research in plant cell engineering, highlighted the application of embryo culture, double haploid (DH) technology, protoplast culture and somatic hybridization, somaclonal variation, rapid propagation, and bio-products production of plant-origin, and t he prospects. (authors)

A comprehensive review of cryogels and their roles in tissue engineering applications.

Science.gov (United States)

Hixon, Katherine R; Lu, Tracy; Sell, Scott A

2017-10-15

The extracellular matrix is fundamental in providing an appropriate environment for cell interaction and signaling to occur. Replicating such a matrix is advantageous in the support of tissue ingrowth and regeneration through the field of tissue engineering. While scaffolds can be fabricated in many ways, cryogels have recently become a popular approach due to their macroporous structure and durability. Produced through the crosslinking of gel precursors followed by a subsequent controlled freeze/thaw cycle, the resulting cryogel provides a unique, sponge-like structure. Therefore, cryogels have proven advantageous for many tissue engineering applications including roles in bioreactor systems, cell separation, and scaffolding. Specifically, the matrix has been demonstrated to encourage the production of various molecules, such as antibodies, and has also been used for cryopreservation. Cryogels can pose as a bioreactor for the expansion of cell lines, as well as a vehicle for cell separation. Lastly, this matrix has shown excellent potential as a tissue engineered scaffold, encouraging regrowth at numerous damaged tissue sites in vivo. This review will briefly discuss the fabrication of cryogels, with an emphasis placed on their application in various facets of tissue engineering to provide an overview of this unique scaffold's past and future roles. Cryogels are unique scaffolds produced through the controlled freezing and thawing of a polymer solution. There is an ever-growing body of literature that demonstrates their applicability in the realm of tissue engineering as extracellular matrix analogue scaffolds; with extensive information having been provided regarding the fabrication, porosity, and mechanical integrity of the scaffolds. Additionally, cryogels have been reviewed with respect to their role in bioseparation and as cellular incubators. This all-inclusive view of the roles that cryogels can play is critical to advancing the technology and expanding its

2D modelling and its applications in engineering

International Nuclear Information System (INIS)

Altinbalik, M. Tahir; İRSEL, Gürkan

2013-01-01

A model, in computer aided engineering applications, may be created by either using a two- dimensional or a three-dimensional design depending on the purpose of design. What matters most in this regard is the selection of a right method to meet system solution requirements in the most economical way. Manufacturability of a design that is developed by utilising computer aided engineering is important, but usability of the data obtained in the course of design works in the production is also equally important. In the applications consisting of such production operations as CNC or plasma cutting, two-dimensional designs can be directly used in production. These machines are equipped with interfaces which converts two-dimensional drawings into codes. In this way, a design can be directly transferred to production, and any arrangements during production process can be synchronously evaluated. As a result of this, investment expenses will be lowered, and thus the costs can be reduced to some extent. In the presented study, we have studied two-dimensional design applications and requirements. We created a two-dimensional design for a part for which a three-dimensional model have previously been generated, and then, we transferred this design to plasma cutting machine, and thus, the operation has been realized experimentally. Key words: Plasma Cutting, 2D modelling, flexibility

2D modelling and its applications in engineering

Energy Technology Data Exchange (ETDEWEB)

Altinbalik, M. Tahir; İRSEL, Gürkan [Trakya University, Faculty of Engineering and Architecture Mechanical Engineering Department, Edİrne (Turkey)

2013-07-01

A model, in computer aided engineering applications, may be created by either using a two- dimensional or a three-dimensional design depending on the purpose of design. What matters most in this regard is the selection of a right method to meet system solution requirements in the most economical way. Manufacturability of a design that is developed by utilising computer aided engineering is important, but usability of the data obtained in the course of design works in the production is also equally important. In the applications consisting of such production operations as CNC or plasma cutting, two-dimensional designs can be directly used in production. These machines are equipped with interfaces which converts two-dimensional drawings into codes. In this way, a design can be directly transferred to production, and any arrangements during production process can be synchronously evaluated. As a result of this, investment expenses will be lowered, and thus the costs can be reduced to some extent. In the presented study, we have studied two-dimensional design applications and requirements. We created a two-dimensional design for a part for which a three-dimensional model have previously been generated, and then, we transferred this design to plasma cutting machine, and thus, the operation has been realized experimentally. Key words: Plasma Cutting, 2D modelling, flexibility.

Advanced Low-Cost O2/H2 Engines for the SSTO Application

Science.gov (United States)

Goracke, B. David; Levack, Daniel J. H.; Nixon, Robert F.

1994-01-01

The recent NASA Access to Space study examined future Earth to orbit (ETO) transportation needs and fleets out to 2030. The baseline in the option 3 assessment was a single stage to orbit (SSTO) vehicle. A study was conducted to assess the use of new advanced low cost O2/H2 engines for this SSTO application. The study defined baseline configurations and ground rules and defined six engine cycles to explore engine performance. The cycles included an open cycle, and a series of closed cycles with varying abilities to extract energy from the propellants to power he turbomachinery. The cycles thus varied in the maximum chamber pressure they could reach and in their weights at any given chamber pressure. The weight of each cycle was calculated for two technology levels versus chamber pressure up to the power limit of the cycle. The performance in the SSTO mission was then modeled using the resulting engine weights and specific impulse performance using the Access to Space option 3 vehicle. The results showed that new O2/H2 engines are viable and competitive candidates for the SSTO application using chamber pressures of 4,000 psi.

Nonlinear approaches in engineering applications advanced analysis of vehicle related technologies

CERN Document Server

Dai, Liming

2016-01-01

This book looks at the broad field of engineering science through the lens of nonlinear approaches. Examples focus on issues in vehicle technology, including vehicle dynamics, vehicle-road interaction, steering, and control for electric and hybrid vehicles. Also included are discussions on train and tram systems, aerial vehicles, robot-human interaction, and contact and scratch analysis at the micro/nanoscale. Chapters are based on invited contributions from world-class experts in the field who advance the future of engineering by discussing the development of more optimal, accurate, efficient, and cost and energy effective systems. This book is appropriate for researchers, students, and practicing engineers who are interested in the applications of nonlinear approaches to solving engineering and science problems.

A review on chitosan centred scaffolds and their applications in tissue engineering.

Science.gov (United States)

Ahmed, Shakeel; Annu; Sheikh, Javed; Ali, Akbar

2018-05-03

The diversity and availability of biopolymer and increased clinical demand for safe scaffolds lead to an increased interest in fabricating scaffolds in order to achieve fruitful progress in tissue engineering. Due to biocompatibility, biodegradability, inherent antimicrobial character, chitosan has drawn ample consideration in recent years. Chitosan is a biopolymer obtained by de-acetylation of chitin extracted from shells of crustaceans and fungi. Due to the presence of reactive functionality in the molecular chain chitosan can be modified either chemically or physically to fabricate the tailor-made scaffolds having desired properties for tissue engineering centered applications. In this review chitosan, its properties and role either virgin, chemically or physically modified, 2D or 3D scaffolds for tissue engineering application have been highlighted. Copyright © 2017. Published by Elsevier B.V.

Linear algebra and linear operators in engineering with applications in Mathematica

CERN Document Server

Davis, H Ted

2000-01-01

Designed for advanced engineering, physical science, and applied mathematics students, this innovative textbook is an introduction to both the theory and practical application of linear algebra and functional analysis. The book is self-contained, beginning with elementary principles, basic concepts, and definitions. The important theorems of the subject are covered and effective application tools are developed, working up to a thorough treatment of eigenanalysis and the spectral resolution theorem. Building on a fundamental understanding of finite vector spaces, infinite dimensional Hilbert spaces are introduced from analogy. Wherever possible, theorems and definitions from matrix theory are called upon to drive the analogy home. The result is a clear and intuitive segue to functional analysis, culminating in a practical introduction to the functional theory of integral and differential operators. Numerous examples, problems, and illustrations highlight applications from all over engineering and the physical ...

Coupled dynamic-multidimensional modelling of free-piston engine combustion

International Nuclear Information System (INIS)

Mikalsen, R.; Roskilly, A.P.

2009-01-01

Free-piston engines are under investigation by a number of research groups worldwide, as an alternative to conventional technology in applications such as electric and hydraulic power generation. The piston dynamics of the free-piston engine differ significantly from those of conventional engines, and this may influence in-cylinder gas motion, combustion and emissions formation. Due to the complex interaction between mechanics and thermodynamics, the modelling of free-piston engines is not straight-forward. This paper presents a novel approach to the modelling of free-piston engines through the introduction of solution-dependent mesh motion in an engine CFD code. The particular features of free-piston engines are discussed, and the model for engine dynamics implemented in the CFD code is described. Finally, the coupled solver is demonstrated through the modelling of a spark ignited free-piston engine generator

Coupled dynamic-multidimensional modelling of free-piston engine combustion

Energy Technology Data Exchange (ETDEWEB)

Mikalsen, R. [Sir Joseph Swan Institute for Energy Research, Newcastle University, Newcastle upon Tyne NE1 7RU (United Kingdom); Roskilly, A.P. [Sir Joseph Swan Institute for Energy Research, Newcastle University, Newcastle upon Tyne NE1 7RU (United Kingdom)], E-mail: tony.roskilly@ncl.ac.uk

2009-01-15

Free-piston engines are under investigation by a number of research groups worldwide, as an alternative to conventional technology in applications such as electric and hydraulic power generation. The piston dynamics of the free-piston engine differ significantly from those of conventional engines, and this may influence in-cylinder gas motion, combustion and emissions formation. Due to the complex interaction between mechanics and thermodynamics, the modelling of free-piston engines is not straight-forward. This paper presents a novel approach to the modelling of free-piston engines through the introduction of solution-dependent mesh motion in an engine CFD code. The particular features of free-piston engines are discussed, and the model for engine dynamics implemented in the CFD code is described. Finally, the coupled solver is demonstrated through the modelling of a spark ignited free-piston engine generator.

Repurposing Mass-produced Internal Combustion Engines Quantifying the Value and Use of Low-cost Internal Combustion Piston Engines for Modular Applications in Energy and Chemical Engineering Industries

Science.gov (United States)

L'Heureux, Zara E.

This thesis proposes that internal combustion piston engines can help clear the way for a transformation in the energy, chemical, and refining industries that is akin to the transition computer technology experienced with the shift from large mainframes to small personal computers and large farms of individually small, modular processing units. This thesis provides a mathematical foundation, multi-dimensional optimizations, experimental results, an engine model, and a techno-economic assessment, all working towards quantifying the value of repurposing internal combustion piston engines for new applications in modular, small-scale technologies, particularly for energy and chemical engineering systems. Many chemical engineering and power generation industries have focused on increasing individual unit sizes and centralizing production. This "bigger is better" concept makes it difficult to evolve and incorporate change. Large systems are often designed with long lifetimes, incorporate innovation slowly, and necessitate high upfront investment costs. Breaking away from this cycle is essential for promoting change, especially change happening quickly in the energy and chemical engineering industries. The ability to evolve during a system's lifetime provides a competitive advantage in a field dominated by large and often very old equipment that cannot respond to technology change. This thesis specifically highlights the value of small, mass-manufactured internal combustion piston engines retrofitted to participate in non-automotive system designs. The applications are unconventional and stem first from the observation that, when normalized by power output, internal combustion engines are one hundred times less expensive than conventional, large power plants. This cost disparity motivated a look at scaling laws to determine if scaling across both individual unit size and number of units produced would predict the two order of magnitude difference seen here. For the first

Transcription Activator-Like Effectors (TALEs) Hybrid Nucleases for Genome Engineering Application

KAUST Repository

Wibowo, Anjar

2011-06-06

Gene targeting is a powerful genome engineering tool that can be used for a variety of biotechnological applications. Genomic double-strand DNA breaks generated by engineered site-specific nucleases can stimulate gene targeting. Hybrid nucleases are composed of DNA binding module and DNA cleavage module. Zinc Finger Nucleases were used to generate double-strand DNA breaks but it suffers from failures and lack of reproducibility. The transcription activator–like effectors (TALEs) from plant pathogenic Xanthomonas contain a unique type of DNA-binding domain that bind specific DNA targets. The purpose of this study is to generate novel sequence specific nucleases by fusing a de novo engineered Hax3 TALE-based DNA binding domain to a FokI cleavage domain. Our data show that the de novo engineered TALE nuclease can bind to its target sequence and create double-strand DNA breaks in vitro. We also show that the de novo engineered TALE nuclease is capable of generating double-strand DNA breaks in its target sequence in vivo, when transiently expressed in Nicotiana benthamiana leaves. In conclusion, our data demonstrate that TALE-based hybrid nucleases can be tailored to bind a user-selected DNA sequence and generate site-specific genomic double-strand DNA breaks. TALE-based hybrid nucleases hold much promise as powerful molecular tools for gene targeting applications.

Electro-spun PLA-PEG-yarns for tissue engineering applications

NARCIS (Netherlands)

Kruse, Magnus; Greuel, Marc; Kreimendahl, Franziska; Schneiders, Thomas; Bauer, Benedict; Gries, Thomas; Jockenhoevel, Stefan

2018-01-01

Electro-spinning is widely used in tissue-engineered applications mostly in form of non-woven structures. The development of e-spun yarn opens the door for textile fabrics which combine the micro to nanoscale dimension of electro-spun filaments with three-dimensional (3D) drapable textile fabrics.

Free-piston Stirling engine system considerations for various space power applications

International Nuclear Information System (INIS)

Dochat, G.R.; Dhar, M.

1991-01-01

The U.S. Government is evaluating power requirements for future space applications. As power requirements increase solar or nuclear dynamic systems become increasingly attractive. Free-Piston Stirling Engines (FPSE) have the potential to provide high reliability, long life, and efficient operation. Therefore, they are excellent candidates for the dynamic power conversion module of a space-based, power-generating system. FPSE can be coupled with many potential heat sources (radioisotope, solar, or nuclear reactor), various heat input systems (pumped loop, heat pipe), heat rejection (pumped loop or heat pipe), and various power management and distribution systems (AC, DC, high or low voltage, and fixed or variable load). This paper will review potential space missions that can be met using free-piston Stirling engines and discusses options of various system integration approaches. Currently free-piston Stirling engine technology for space power applications is being developed under contract with NASA-Lewis Research Center. This paper will also briefly outline the program and recent progress

Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine Applications

Science.gov (United States)

2015-09-01

well as engine ef- ficiency. Similar trends are also found in other applications such as rocket propulsion systems and gas turbine engines. This has...state representation near the critical point (Miller et al. 2001). The cubic state equation is written as, p = RT V − Bm − Am V2 + 2VBm + B2m , (2.1...injection for liquid rockets and their implications. Int. J. Aerosp. Eng. 2012. Chung, T. H., Ajlan, M., Lee, L. L. & Starling, K. E. 1988 Generalized

Situational Requirements Engineering for the Development of Content Management System-based Web Applications

NARCIS (Netherlands)

Souer, J.; van de Weerd, I.; Versendaal, J.M.; Brinkkemper, S.

2005-01-01

Web applications are evolving towards strong content-centered Web applications. The development processes and implementation of these applications are unlike the development and implementation of traditional information systems. In this paper we propose WebEngineering Method; a method for developing

Graphene directed architecture of fine engineered nanostructures with electrochemical applications

DEFF Research Database (Denmark)

Hou, Chengyi; Zhang, Minwei; Halder, Arnab

2017-01-01

, and polymers has led to the possibility to create new electroactive and multifunctional nanostructures, which can serve as promising material platforms for electrochemical purposes. However, the precise control and fine-tuning of material structures and properties are still challenging and in demand...... classified nanostructures, including metallic nanostructures, self-assembled organic and supramolecular structures, and fine engineered metal oxides. In these cases, graphene templates either sacrificed during templating synthesis or retained as support for final products. We also discuss remained challenges....... In this review, we aim to highlight some recent efforts devoted to rational design, assembly and fine engineering of electrochemically active nanostructures using graphene or/and its derivatives as soft templates for controlled synthesis and directed growth. We organize the contents according to the chemically...

Handbook of power systems engineering with power electronics applications

CERN Document Server

Hase, Yoshihide

2012-01-01

Formerly known as Handbook of Power System Engineering, this second edition provides rigorous revisions to the original treatment of systems analysis together with a substantial new four-chapter section on power electronics applications. Encompassing a whole range of equipment, phenomena, and analytical approaches, this handbook offers a complete overview of power systems and their power electronics applications, and presents a thorough examination of the fundamental principles, combining theories and technologies that are usually treated in separate specialised fields, in a single u

Metabolic engineering of volatile isoprenoids in plants and microbes.

Science.gov (United States)

Vickers, Claudia E; Bongers, Mareike; Liu, Qing; Delatte, Thierry; Bouwmeester, Harro

2014-08-01

The chemical properties and diversity of volatile isoprenoids lends them to a broad variety of biological roles. It also lends them to a host of biotechnological applications, both by taking advantage of their natural functions and by using them as industrial chemicals/chemical feedstocks. Natural functions include roles as insect attractants and repellents, abiotic stress protectants in pathogen defense, etc. Industrial applications include use as pharmaceuticals, flavours, fragrances, fuels, fuel additives, etc. Here we will examine the ways in which researchers have so far found to exploit volatile isoprenoids using biotechnology. Production and/or modification of volatiles using metabolic engineering in both plants and microorganisms are reviewed, including engineering through both mevalonate and methylerythritol diphosphate pathways. Recent advances are illustrated using several case studies (herbivores and bodyguards, isoprene, and monoterpene production in microbes). Systems and synthetic biology tools with particular utility for metabolic engineering are also reviewed. Finally, we discuss the practical realities of various applications in modern biotechnology, explore possible future applications, and examine the challenges of moving these technologies forward so that they can deliver tangible benefits. While this review focuses on volatile isoprenoids, many of the engineering approaches described here are also applicable to non-isoprenoid volatiles and to non-volatile isoprenoids. © 2014 John Wiley & Sons Ltd.

Space tug applications. Final report

International Nuclear Information System (INIS)

1996-01-01

This article is the final report of the conceptual design efforts for a 'space tug'. It includes preliminary efforts, mission analysis, configuration analysis, impact analysis, and conclusions. Of the several concepts evaluated, the nuclear bimodal tug was one of the top candidates, with the two options being the NEBA-1 and NEBA-3 systems. Several potential tug benefits were identified during the mission analysis. The tug enables delivery of large (>3,500 kg) payloads to the outer planets and it increases the GSO delivery capability by 20% relative to current systems. By providing end of life disposal, the tug can be used to extend the life of existing space assets. It can also be used to reboost satellites which were not delivered to their final orbit by the launch system. A specific mission model is the key to validating the tug concept. Once a mission model can be established, mission analysis can be used to determine more precise propellant quantities and burn times. In addition, the specific payloads can be evaluated for mass and volume capability with the launch systems. Results of the economic analysis will be dependent on the total years of operations and the number of missions in the mission model. The mission applications evaluated during this phase drove the need for large propellant quantities and thus did not allow the payloads to step down to smaller and less expensive launch systems

Conformal geometry computational algorithms and engineering applications

CERN Document Server

Jin, Miao; He, Ying; Wang, Yalin

2018-01-01

This book offers an essential overview of computational conformal geometry applied to fundamental problems in specific engineering fields. It introduces readers to conformal geometry theory and discusses implementation issues from an engineering perspective.  The respective chapters explore fundamental problems in specific fields of application, and detail how computational conformal geometric methods can be used to solve them in a theoretically elegant and computationally efficient way. The fields covered include computer graphics, computer vision, geometric modeling, medical imaging, and wireless sensor networks. Each chapter concludes with a summary of the material covered and suggestions for further reading, and numerous illustrations and computational algorithms complement the text.  The book draws on courses given by the authors at the University of Louisiana at Lafayette, the State University of New York at Stony Brook, and Tsinghua University, and will be of interest to senior undergraduates, gradua...

Lot-sizing algorithms with applications to engineering and economics

DEFF Research Database (Denmark)

Vidal, Rene Victor Valqui; Ferreira, Jose S.

1984-01-01

of time-varying parameters. A comparison of the efficiency of the new solution procedures with well-known methods is developed. New applications of the techniques described within the fields of engineering (optimal design of a pump-pipe system) and economics (a model for import-planning) are referred to...

Hydraulic modeling development and application in water resources engineering

Science.gov (United States)

Simoes, Francisco J.; Yang, Chih Ted; Wang, Lawrence K.

2015-01-01

The use of modeling has become widespread in water resources engineering and science to study rivers, lakes, estuaries, and coastal regions. For example, computer models are commonly used to forecast anthropogenic effects on the environment, and to help provide advanced mitigation measures against catastrophic events such as natural and dam-break floods. Linking hydraulic models to vegetation and habitat models has expanded their use in multidisciplinary applications to the riparian corridor. Implementation of these models in software packages on personal desktop computers has made them accessible to the general engineering community, and their use has been popularized by the need of minimal training due to intuitive graphical user interface front ends. Models are, however, complex and nontrivial, to the extent that even common terminology is sometimes ambiguous and often applied incorrectly. In fact, many efforts are currently under way in order to standardize terminology and offer guidelines for good practice, but none has yet reached unanimous acceptance. This chapter provides a view of the elements involved in modeling surface flows for the application in environmental water resources engineering. It presents the concepts and steps necessary for rational model development and use by starting with the exploration of the ideas involved in defining a model. Tangible form of those ideas is provided by the development of a mathematical and corresponding numerical hydraulic model, which is given with a substantial amount of detail. The issues of model deployment in a practical and productive work environment are also addressed. The chapter ends by presenting a few model applications highlighting the need for good quality control in model validation.

Engineering Thermostable Microbial Xylanases Toward its Industrial Applications.

Science.gov (United States)

Kumar, Vishal; Dangi, Arun Kumar; Shukla, Pratyoosh

2018-03-01

Xylanases are one of the important hydrolytic enzymes which hydrolyze the β-1, 4 xylosidic linkage of the backbone of the xylan polymeric chain which consists of xylose subunits. Xylanases are mainly found in plant cell walls and are produced by several kinds of microorganisms such as fungi, bacteria, yeast, and some protozoans. The fungi are considered as most potent xylanase producers than that of yeast and bacteria. There is a broad series of industrial applications for the thermostable xylanase as an industrial enzyme. Thermostable xylanases have been used in a number of industries such as paper and pulp industry, biofuel industry, food and feed industry, textile industry, etc. The present review explores xylanase-substrate interactions using gene-editing tools toward the comprehension in improvement in industrial stability of xylanases. The various protein-engineering and metabolic-engineering methods have also been explored to improve operational stability of xylanase. Thermostable xylanases have also been used for improvement in animal feed nutritional value. Furthermore, they have been used directly in bakery and breweries, including a major use in paper and pulp industry as a biobleaching agent. This present review envisages some of such applications of thermostable xylanases for their bioengineering.

Functionalized Ormosil Scaffolds Processed by Direct Laser Polymerization for Application in Tissue Engineering

DEFF Research Database (Denmark)

Matei, A.; Schou, Jørgen; Canulescu, Stela

The N,N’-(methacryloyloxyethyl triehtoxy silyl propyl carbamoyl-oxyhexyl)-urea hybrid methacrylate for applications in tissue engineering was synthesized and afterwards polymerized by direct laser polymerization using femtosecond laser pulses with the aim of using it for further applications...... in tissue engineering. The as-obtained scaffolds were modified either by low pressure argon plasma treatment or by using two different proteins (lysozyme, fibrinogen). For improved adhesion, the proteins were deposited by matrix assisted pulsed laser evaporation. The functionalized structures were tested...

Final Rule for Control of Air Pollution From New Motor Vehicles and New Motor Vehicle Engines; Non-Conformance Penalties for 2004 and later Model Year Emission Standards for Heavy-Duty Diesel Engines and Heavy-Duty Diesel Vehicles

Science.gov (United States)

Final Rule for Control of Air Pollution From New Motor Vehicles and New Motor Vehicle Engines; Non-Conformance Penalties for 2004 and later Model Year Emission Standards for Heavy-Duty Diesel Engines and Heavy-Duty Diesel Vehicles

Application of human engineering to design of central control room and evaluation

International Nuclear Information System (INIS)

Tani, Mamoru

1986-01-01

The central control room of a nuclear power station is the center of the operation control, monitoring and management of the plant, therefore, the design by the application of human engineering has been performed on the basis of the experience and achievement in thermal power stations and other industries. In this report, the application of human engineering to the development of the new control boards for PWRs and the evaluation are described. In a nuclear power station, the number of the machinery and equipment composing it is large, and the interrelation among them is complex, accordingly, in the information processing system for operation monitoring and control, the man-machine interface works with high density. The concept of multiple protection design requires to show numerous plant parameters on a central control board, and this also complicates the man-machine interface. The introduction of human engineering was seriously studied after the TMI accident. In order to increase the safety and reliability of a plant, the new central control and monitoring system aims at facilitating operation and monitoring, and lightening burden and preventing mistakes in handling and judgement. The operational sequence diagram and mock-up varification, the application of human engineering and the evaluation, the synthetic real-time verification at the time of abnormality and accident, and the evaluation of the reliability improvement of men are reported. (Kako, I.)

AIMES Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Katz, Daniel S [Univ. of Illinois, Urbana-Champaign, IL (United States). National Center for Supercomputing Applications (NCSA); Jha, Shantenu [Rutgers Univ., New Brunswick, NJ (United States); Weissman, Jon [Univ. of Minnesota, Minneapolis, MN (United States); Turilli, Matteo [Rutgers Univ., New Brunswick, NJ (United States)

2017-01-31

This is the final technical report for the AIMES project. Many important advances in science and engineering are due to large-scale distributed computing. Notwithstanding this reliance, we are still learning how to design and deploy large-scale production Distributed Computing Infrastructures (DCI). This is evidenced by missing design principles for DCI, and an absence of generally acceptable and usable distributed computing abstractions. The AIMES project was conceived against this backdrop, following on the heels of a comprehensive survey of scientific distributed applications. AIMES laid the foundations to address the tripartite challenge of dynamic resource management, integrating information, and portable and interoperable distributed applications. Four abstractions were defined and implemented: skeleton, resource bundle, pilot, and execution strategy. The four abstractions were implemented into software modules and then aggregated into the AIMES middleware. This middleware successfully integrates information across the application layer (skeletons) and resource layer (Bundles), derives a suitable execution strategy for the given skeleton and enacts its execution by means of pilots on one or more resources, depending on the application requirements, and resource availabilities and capabilities.

Constructing an Efficient Self-Tuning Aircraft Engine Model for Control and Health Management Applications

Science.gov (United States)

Armstrong, Jeffrey B.; Simon, Donald L.

2012-01-01

Self-tuning aircraft engine models can be applied for control and health management applications. The self-tuning feature of these models minimizes the mismatch between any given engine and the underlying engineering model describing an engine family. This paper provides details of the construction of a self-tuning engine model centered on a piecewise linear Kalman filter design. Starting from a nonlinear transient aerothermal model, a piecewise linear representation is first extracted. The linearization procedure creates a database of trim vectors and state-space matrices that are subsequently scheduled for interpolation based on engine operating point. A series of steady-state Kalman gains can next be constructed from a reduced-order form of the piecewise linear model. Reduction of the piecewise linear model to an observable dimension with respect to available sensed engine measurements can be achieved using either a subset or an optimal linear combination of "health" parameters, which describe engine performance. The resulting piecewise linear Kalman filter is then implemented for faster-than-real-time processing of sensed engine measurements, generating outputs appropriate for trending engine performance, estimating both measured and unmeasured parameters for control purposes, and performing on-board gas-path fault diagnostics. Computational efficiency is achieved by designing multidimensional interpolation algorithms that exploit the shared scheduling of multiple trim vectors and system matrices. An example application illustrates the accuracy of a self-tuning piecewise linear Kalman filter model when applied to a nonlinear turbofan engine simulation. Additional discussions focus on the issue of transient response accuracy and the advantages of a piecewise linear Kalman filter in the context of validation and verification. The techniques described provide a framework for constructing efficient self-tuning aircraft engine models from complex nonlinear

The development and application of engineered proteins for bioremediation

Energy Technology Data Exchange (ETDEWEB)

Trewhella, J. [ed.

1995-09-26

Clean up of the toxic legacy of the Cold War is projected to be the most expensive domestic project the nation has yet undertaken. Remediation of the Department of Energy and Department of Defense toxic waste sites alone are projected to cost {approximately}$1 trillion over a 20-30 year period. New, cost effective technologies are needed to attack this enormous problem. Los Alamos has put together a cross-divisional team of scientist to develop science based bioremediation technology to work toward this goal. In the team we have expertise in: (1) molecular, ecosystem and transport modeling; (2) genetic and protein engineering; (3) microbiology and microbial ecology; (4) structural biology; and (5) bioinorganic chemistry. This document summarizes talks at a workshop of different aspects of bioremediation technology including the following: Introducing novel function into a Heme enzyme: engineering by excavation; cytochrome P-450: ideal systems for bioremediation?; selection and development of bacterial strains for in situ remediation of cholorinated solvents; genetic analysis and preparation of toluene ortho-monooxygenase for field application in remediation of trichloroethylene; microbial ecology and diversity important to bioremediation; engineering haloalkane dehalogenase for bioremediation; enzymes for oxidative biodegradation; indigenous bacteria as hosts for engineered proteins; performance of indigenous bacterial, hosting engineered proteins in microbial communities.

Osteochondral tissue engineering: scaffolds, stem cells and applications

Science.gov (United States)

Nooeaid, Patcharakamon; Salih, Vehid; Beier, Justus P; Boccaccini, Aldo R

2012-01-01

Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self-repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral tissue engineering, which are focused on the application of various materials forming bilayered composite scaffolds, including polymers and ceramics, discussing the variety of scaffold designs and fabrication methods being developed. Additionally, cell sources and biological protein incorporation methods are discussed, addressing their interaction with scaffolds and highlighting the potential for creating a new generation of bilayered composite scaffolds that can mimic the native interfacial tissue properties, and are able to adapt to the biological environment. PMID:22452848

Amended Final Report - Antibodies to Radionuclides. Engineering by Surface Display for Immunosensors

Energy Technology Data Exchange (ETDEWEB)

Blake, Diane A. [Tulane Univ., New Orleans, LA (United States)

2013-06-14

The relatively new techniques of antibody display, which permit molecular engineering of antibody structure and function, have the potential to revolutionize the way scientists generate binding proteins for specific applications. However, the skills required to efficiently use antibody display techniques have proven difficult for other laboratories to acquire without hands-on training and exchange of laboratory personnel. This research project is designed bring important expertise in antibody display to the State of Louisiana while pursuing a project with direct relevance to the DOE’s EM program.

Generating Southern Africa Precipitation Forecast Using the FEWS Engine, a New Application for the Google Earth Engine

Science.gov (United States)

Landsfeld, M. F.; Hegewisch, K.; Daudert, B.; Morton, C.; Husak, G. J.; Friedrichs, M.; Funk, C. C.; Huntington, J. L.; Abatzoglou, J. T.; Verdin, J. P.

2016-12-01

The Famine Early Warning Systems Network (FEWS NET) focuses on food insecurity in developing nations and provides objective, evidence-based analysis to help government decision-makers and relief agencies plan for and respond to humanitarian emergencies. The network of FEWS NET analysts and scientists require flexible, interactive tools to aid in their monitoring and research efforts. Because they often work in bandwidth-limited regions, lightweight Internet tools and services that bypass the need for downloading massive datasets are preferred for their work. To support food security analysis FEWS NET developed a custom interface for the Google Earth Engine (GEE). GEE is a platform developed by Google to support scientific analysis of environmental data in their cloud computing environment. This platform allows scientists and independent researchers to mine massive collections of environmental data, leveraging Google's vast computational resources for purposes of detecting changes and monitoring the Earth's surface and climate. GEE hosts an enormous amount of satellite imagery and climate archives, one of which is the Climate Hazards Group Infrared Precipitation with Stations dataset (CHIRPS). CHIRPS precipitation dataset is a key input for FEWS NET monitoring and forecasting efforts. In this talk we introduce the FEWS Engine interface. We present an application that highlights the utility of FEWS Engine for forecasting the upcoming seasonal precipitation of southern Africa. Specifically, the current state of ENSO is assessed and used to identify similar historical seasons. The FEWS Engine compositing tool is used to examine rainfall and other environmental data for these analog seasons. The application illustrates the unique benefits of using FEWS Engine for on-the-fly food security scenario development.

Final report: Compiled MPI. Cost-Effective Exascale Application Development

Energy Technology Data Exchange (ETDEWEB)

Gropp, William Douglas [Univ. of Illinois, Urbana-Champaign, IL (United States)

2015-12-21

This is the final report on Compiled MPI: Cost-Effective Exascale Application Development, and summarizes the results under this project. The project investigated runtime enviroments that improve the performance of MPI (Message-Passing Interface) programs; work at Illinois in the last period of this project looked at optimizing data access optimizations expressed with MPI datatypes.

Orthogonal polarization in lasers physical phenomena and engineering applications

CERN Document Server

Zhang, Shulian

2013-01-01

This practical book summarizes the latest research results of orthogonally polarized lasers, birefringence laser cavities, and their applications. Coverage ranges from basic principles and technologies to the characteristics of different cavities and lasers to various measurement techniques. A number of figures, experimental designs, and measurement curves are included, helping readers gain a thorough understanding of the many applications in modern engineering and start their own projects. Many types of relevant lasers (Helium/Neon lasers, Nd:YAG lasers, laser diodes, etc.) are also discussed

A Review on Atomization and Sprays of Biofuels for IC Engine Applications

Directory of Open Access Journals (Sweden)

Prasad Boggavarapu

2013-06-01

Full Text Available Ever increasing energy requirements, environmental concerns and energy security needs are strongly influencing engine researchers to consider renewable biofuels as alternatives to fossil fuels. Spray process being important in IC engine combustion, existing literature on various biofuel sprays is reviewed and summarized. Both experimental and computational research findings are reviewed in a detailed manner for compression ignition (CI engine sprays and briefly for spark ignition (SI engine sprays. The physics of basic atomization process of sprays from various injectors is included to highlight the most recent research findings followed by discussion highlighting the effect of physico-chemical properties on spray atomization for both biofuels and fossil fuels. Biodiesel sprays are found to penetrate faster and have narrow spray plume angle and larger droplet sizes compared to diesel. Results of analytical and computational models are shown to be useful in shedding light on the actual process of atomization. However, further studies on understanding primary atomization and the effect of fuel properties on primary atomization are required. As far as secondary atomization is concerned, changes in regimes are observed to occur at higher air-jet velocities for biodiesel compared to those of diesel. Evaporating sprays revealed that the liquid length is longer for biodiesel. Pure plant oil sprays with potential use in CI engines may require alternative injector technology due to slower breakup as compared to diesel. Application of ethanol to gasoline engines may be feasible without any modifications to port fuel injection (PFI engines. More studies are required on the application of alternative fuels to high pressure sprays used in Gasoline Direct Injection (GDI engines.

Application of some ideas from the axiomatic design principles for construction of a learning management system in Romanian higher engineering education

Directory of Open Access Journals (Sweden)

Iliescu Dragoş

2017-01-01

Full Text Available In education, the communication processes are critical. The result of education process depends on a significant manner by the quality of the incurred communication. To enhance learning in higher engineering education, an application of axiomatic design for the construction of a Learning Management System is proposed. The clients of such a system are identified, and their expectations were gathered as well. Functional requirements and design parameters to be designed are compiled regarding the two principles of axiomatic design. Finally, we investigate four design options to select the optimal design solution.

Protein engineering of enzymes for process applications

DEFF Research Database (Denmark)

Woodley, John M

2013-01-01

opportunities will be targeted on modification to enable process application. This article discusses the challenges involved in enzyme modification focused on process requirements, such as the need to fulfill reaction thermodynamics, specific activity under the required conditions, kinetics at required...... concentrations, and stability. Finally, future research directions are discussed, including the integration of biocatalysis with neighboring chemical steps....

Application of polarization OCT in tissue engineering

Science.gov (United States)

Yang, Ying; Ahearne, Mark; Bagnaninchi, Pierre O.; Hu, Bin; Hampson, Karen; El Haj, Alicia J.

2008-02-01

For tissue engineering of load-bearing tissues, such as bone, tendon, cartilage, and cornea, it is critical to generate a highly organized extracellular matrix. The major component of the matrix in these tissues is collagen, which usually forms a highly hierarchical structure with increasing scale from fibril to fiber bundles. These bundles are ordered into a 3D network to withstand forces such as tensile, compressive or shear. To induce the formation of organized matrix and create a mimic body environment for tissue engineering, in particular, tendon tissue engineering, we have fabricated scaffolds with features to support the formation of uniaxially orientated collagen bundles. In addition, mechanical stimuli were applied to stimulate tissue formation and matrix organization. In parallel, we seek a nondestructive tool to monitor the changes within the constructs in response to these external stimulations. Polarizationsensitive optical coherence tomography (PSOCT) is a non-destructive technique that provides functional imaging, and possesses the ability to assess in depth the organization of tissue. In this way, an engineered tissue construct can be monitored on-line, and correlated with the application of different stimuli by PSOCT. We have constructed a PSOCT using a superluminescent diode (FWHM 52nm) in this study and produced two types of tendon constructs. The matrix structural evolution under different mechanical stimulation has been evaluated by the PSOCT. The results in this study demonstrate that PSOCT was a powerful tool enabling us to monitor non-destructively and real time the progressive changes in matrix organization and assess the impact of various stimuli on tissue orientation and growth.

Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering.

Science.gov (United States)

Zhao, Wen; Li, Jiaojiao; Jin, Kaixiang; Liu, Wenlong; Qiu, Xuefeng; Li, Chenrui

2016-02-01

Electrospun PLGA-based scaffolds have been applied extensively in biomedical engineering, such as tissue engineering and drug delivery system. Due to lack of the recognition sites on cells, hydropholicity and single-function, the applications of PLGA fibrous scaffolds are limited. In order to tackle these issues, many works have been done to obtain functional PLGA-based scaffolds, including surface modifications, the fabrication of PLGA-based composite scaffolds and drug-loaded scaffolds. The functional PLGA-based scaffolds have significantly improved cell adhesion, attachment and proliferation. Moreover, the current study has summarized the applications of functional PLGA-based scaffolds in wound dressing, vascular and bone tissue engineering area as well as drug delivery system. Copyright © 2015 Elsevier B.V. All rights reserved.

Development of Desktop Computing Applications and Engineering Tools on GPUs

DEFF Research Database (Denmark)

Sørensen, Hans Henrik Brandenborg; Glimberg, Stefan Lemvig; Hansen, Toke Jansen

(GPUs) for high-performance computing applications and software tools in science and engineering, inverse problems, visualization, imaging, dynamic optimization. The goals are to contribute to the development of new state-of-the-art mathematical models and algorithms for maximum throughout performance...

Final Technical Report and management: NUCLEAR ENGINEERING RECRUITMENT EFFORT

International Nuclear Information System (INIS)

Kerrick, Sharon S.; Vincent, Charles D.

2007-01-01

This report provides the summary of a project whose purpose was to support the costs of developing a nuclear engineering awareness program, an instruction program for teachers to integrate lessons on nuclear science and technology into their existing curricula, and web sites for the exchange of nuclear engineering career information and classroom materials. The specific objectives of the program were as follows: Objective 1--Increase awareness and interest of nuclear engineering; Objective 2--Instruct Teachers on nuclear topics; Objective 3--Nuclear education programs web-site; Objective 4--Support to university/industry matching grants and reactor sharing; Objective 5--Pilot project; and Objective 6--Nuclear engineering enrollment survey at universities

Workshop on the applications of new computer tools to thermal engineering; Applications a la thermique des nouveaux outils informatiques

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

This workshop on the applications of new computer tools to thermal engineering has been organized by the French society of thermal engineers. Seven papers have been presented, from which two papers dealing with thermal diffusivity measurements in materials and with the optimization of dryers have been selected for ETDE. (J.S.)

Evaluation of undeveloped rocket engine cycle applications to advanced transportation

Science.gov (United States)

1990-01-01

Undeveloped pump-fed, liquid propellant rocket engine cycles were assessed and evaluated for application to Next Manned Transportation System (NMTS) vehicles, which would include the evolving Space Transportation System (STS Evolution), the Personnel Launch System (PLS), and the Advanced Manned Launch System (AMLS). Undeveloped engine cycles selected for further analysis had potential for increased reliability, more maintainability, reduced cost, and improved (or possibly level) performance when compared to the existing SSME and proposed STME engines. The split expander (SX) cycle, the full flow staged combustion (FFSC) cycle, and a hybrid version of the FFSC, which has a LOX expander drive for the LOX pump, were selected for definition and analysis. Technology requirements and issues were identified and analyses of vehicle systems weight deltas using the SX and FFSC cycles in AMLS vehicles were performed. A strawman schedule and cost estimate for FFSC subsystem technology developments and integrated engine system demonstration was also provided.

Design, Optimization and Application of Small Molecule Biosensor in Metabolic Engineering.

Science.gov (United States)

Liu, Yang; Liu, Ye; Wang, Meng

2017-01-01

The development of synthetic biology and metabolic engineering has painted a great future for the bio-based economy, including fuels, chemicals, and drugs produced from renewable feedstocks. With the rapid advance of genome-scale modeling, pathway assembling and genome engineering/editing, our ability to design and generate microbial cell factories with various phenotype becomes almost limitless. However, our lack of ability to measure and exert precise control over metabolite concentration related phenotypes becomes a bottleneck in metabolic engineering. Genetically encoded small molecule biosensors, which provide the means to couple metabolite concentration to measurable or actionable outputs, are highly promising solutions to the bottleneck. Here we review recent advances in the design, optimization and application of small molecule biosensor in metabolic engineering, with particular focus on optimization strategies for transcription factor (TF) based biosensors.

[Application of silk-based tissue engineering scaffold for tendon / ligament regeneration].

Science.gov (United States)

Hu, Yejun; Le, Huihui; Jin, Zhangchu; Chen, Xiao; Yin, Zi; Shen, Weiliang; Ouyang, Hongwei

2016-03-01

Tendon/ligament injury is one of the most common impairments in sports medicine. The traditional treatments of damaged tissue repair are unsatisfactory, especially for athletes, due to lack of donor and immune rejection. The strategy of tissue engineering may break through these limitations, and bring new hopes to tendon/ligament repair, even regeneration. Silk is a kind of natural biomaterials, which has good biocompatibility, wide range of mechanical properties and tunable physical structures; so it could be applied as tendon/ligament tissue engineering scaffolds. The silk-based scaffold has robust mechanical properties; combined with other biological ingredients, it could increase the surface area, promote more cell adhesion and improve the biocompatibility. The potential clinical application of silk-based scaffold has been confirmed by in vivo studies on tendon/ligament repairing, such as anterior cruciate ligament, medial collateral ligament, achilles tendon and rotator cuff. To develop novel biomechanically stable and host integrated tissue engineered tendon/ligament needs more further micro and macro studies, combined with product development and clinical application, which will give new hope to patients with tendon/ligament injury.

Application of wear resistant spraying for diesel engine; Diesel kikan eno taimamo yosha no tekiyo

Energy Technology Data Exchange (ETDEWEB)

Kitajima, Y. [Mitsui Engineering and Shipbuliding Co. Ltd., Tokyo (Japan)

1999-03-31

Diesel engines used widely as propelling engines of ships have increasingly been provided with a high output and a high thermal efficiency; their structural members, particularly, the component parts for combustion chambers are therefore used under severe conditions, giving rise to the need of surface treatment and surface reforming of the members. Parts for marine diesel engines are huge, so that the technology applicable to the surface treatment and reforming are limited in point of facility and cost; therefore, most suitable is thermal spraying. This paper primarily discusses, among marine diesel engines, a 2-cycle low-speed engine with a 260-980mm bore used for the main engine of a merchant ship such as a container ship, bulk carrier or a tanker, and a 4-cycle medium-speed engine with a 300-420mm bore used for the main engine of a naval vessel; the paper explains the application status of a thermal spraying technology which is in progress to cope with the high output and high thermal efficiency of the diesel engines, explaining particularly the story of the development and the technological features of the wear resistant thermal spraying, which has been put to practical use, on the cylinder liner and the piston ring of the 4-cycle medium-speed engine. (NEDO)

Nanofibrous silk fibroin/reduced graphene oxide scaffolds for tissue engineering and cell culture applications.

Science.gov (United States)

Nalvuran, Hande; Elçin, Ayşe Eser; Elçin, Yaşar Murat

2018-03-16

Graphene and silk fibroin (SF) have been extensively investigated in the literature. Hybrid scaffolds of SF and graphene combine the properties of both of the materials and provide promising applications for tissue engineering purposes. In this study, reduced graphene oxide (RGO) (0.5%, 1.0% and 2.0% (w/v)) was incorporated into SF and fabricated into composite nanofibers through electrospinning. The fibers were characterized and analyzed by SEM, XRD, FTIR, TGA, circular dichroism analysis, contact angle measurements and tensile tests. Here, we document that the presence of RGO increases intermolecular forces between RGO and SF molecular chains in the SF matrix, which results in an increased silk II content. Upon the incorporation of RGO, thermal stability and mechanical properties of the fibers significantly improved. Furthermore, in-vitro findings showed that composite nanofibers supported cell viability and were hemocompatible. Finally, bone marrow mesenchymal stem cells were induced osteogenically on electrospun SF/RGO mats for 30days, which showed that the substrate supported osteogenic differentiation. In this study, a feasible method is proposed to generate biocompatible and versatile SF/RGO-composite nanofibers that can influence biomedical applications. Copyright © 2018. Published by Elsevier B.V.

Electric utility engineer`s FGD manual -- Volume 1: FGD process design. Final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-04

Part 1 of the Electric Utility Engineer`s Flue Gas Desulfurization (FGD) Manual emphasizes the chemical and physical processes that form the basis for design and operation of lime- and limestone-based FGD systems applied to coal- or oil-fired steam electric generating stations. The objectives of Part 1 are: to provide a description of the chemical and physical design basis for lime- and limestone-based wet FGD systems; to identify and discuss the various process design parameters and process options that must be considered in developing a specification for a new FGD system; and to provide utility engineers with process knowledge useful for operating and optimizing a lime- or limestone-based wet FGD system.

Tissue Engineering Applications of Three-Dimensional Bioprinting.

Science.gov (United States)

Zhang, Xiaoying; Zhang, Yangde

2015-07-01

Recent advances in tissue engineering have adapted the additive manufacturing technology, also known as three-dimensional printing, which is used in several industrial applications, for the fabrication of bioscaffolds and viable tissue and/or organs to overcome the limitations of other in vitro conventional methods. 3D bioprinting technology has gained enormous attention as it enabled 3D printing of a multitude of biocompatible materials, different types of cells and other supporting growth factors into complex functional living tissues in a 3D format. A major advantage of this technology is its ability for simultaneously 3D printing various cell types in defined spatial locations, which makes this technology applicable to regenerative medicine to meet the need for suitable for transplantation suitable organs and tissues. 3D bioprinting is yet to successfully overcome the many challenges related to building 3D structures that closely resemble native organs and tissues, which are complex structures with defined microarchitecture and a variety of cell types in a confined area. An integrated approach with a combination of technologies from the fields of engineering, biomaterials science, cell biology, physics, and medicine is required to address these complexities. Meeting this challenge is being made possible by directing the 3D bioprinting to manufacture biomimetic-shaped 3D structures, using organ/tissue images, obtained from magnetic resonance imaging and computerized tomography, and employing computer-aided design and manufacturing technologies. Applications of 3D bioprinting include the generation of multilayered skin, bone, vascular grafts, heart valves, etc. The current 3D bioprinting technologies need to be improved with respect to the mechanical strength and integrity in the manufactured constructs as the presently used biomaterials are not of optimal viscosity. A better understanding of the tissue/organ microenvironment, which consists of multiple types of

Activities of the Institute for Computer Applications in Science and Engineering

Science.gov (United States)

1985-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, numerical analysis, and computer science during the period April 1, 1985 through October 2, 1985 is summarized.

Development of Synthetic and Natural Materials for Tissue Engineering Applications Using Adipose Stem Cells

Directory of Open Access Journals (Sweden)

Yunfan He

2016-01-01

Full Text Available Adipose stem cells have prominent implications in tissue regeneration due to their abundance and relative ease of harvest from adipose tissue and their abilities to differentiate into mature cells of various tissue lineages and secrete various growth cytokines. Development of tissue engineering techniques in combination with various carrier scaffolds and adipose stem cells offers great potential in overcoming the existing limitations constraining classical approaches used in plastic and reconstructive surgery. However, as most tissue engineering techniques are new and highly experimental, there are still many practical challenges that must be overcome before laboratory research can lead to large-scale clinical applications. Tissue engineering is currently a growing field of medical research; in this review, we will discuss the progress in research on biomaterials and scaffolds for tissue engineering applications using adipose stem cells.

Laser ignition - Spark plug development and application in reciprocating engines

Science.gov (United States)

Pavel, Nicolaie; Bärwinkel, Mark; Heinz, Peter; Brüggemann, Dieter; Dearden, Geoff; Croitoru, Gabriela; Grigore, Oana Valeria

2018-03-01

Combustion is one of the most dominant energy conversion processes used in all areas of human life, but global concerns over exhaust gas pollution and greenhouse gas emission have stimulated further development of the process. Lean combustion and exhaust gas recirculation are approaches to improve the efficiency and to reduce pollutant emissions; however, such measures impede reliable ignition when applied to conventional ignition systems. Therefore, alternative ignition systems are a focus of scientific research. Amongst others, laser induced ignition seems an attractive method to improve the combustion process. In comparison with conventional ignition by electric spark plugs, laser ignition offers a number of potential benefits. Those most often discussed are: no quenching of the combustion flame kernel; the ability to deliver (laser) energy to any location of interest in the combustion chamber; the possibility of delivering the beam simultaneously to different positions, and the temporal control of ignition. If these advantages can be exploited in practice, the engine efficiency may be improved and reliable operation at lean air-fuel mixtures can be achieved, making feasible savings in fuel consumption and reduction in emission of exhaust gasses. Therefore, laser ignition can enable important new approaches to address global concerns about the environmental impact of continued use of reciprocating engines in vehicles and power plants, with the aim of diminishing pollutant levels in the atmosphere. The technology can also support increased use of electrification in powered transport, through its application to ignition of hybrid (electric-gas) engines, and the efficient combustion of advanced fuels. In this work, we review the progress made over the last years in laser ignition research, in particular that aimed towards realizing laser sources (or laser spark plugs) with dimensions and properties suitable for operating directly on an engine. The main envisaged

Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs

DEFF Research Database (Denmark)

Pedde, R. Daniel; Mirani, Bahram; Navaei, Ali

2017-01-01

, outlines the use of common biomaterials and advanced hybrid scaffolds, and describes several design considerations including the structural, physical, biological, and economical parameters that are crucial for the fabrication of functional, complex, engineered tissues. Finally, the applications...... of these biofabrication strategies in neural, skin, connective, and muscle tissue engineering are explored.......The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing...

Effects of sterilization and storage on the properties of ALP-grafted biomaterials for prosthetic and bone tissue engineering applications

International Nuclear Information System (INIS)

Ferraris, S; Pan, G; Vernè, E; Spriano, S; Cassinelli, C; Mazzucco, L

2012-01-01

Grafting of the biomaterial surfaces with biomolecules is nowadays a challenging research field for prosthetic and bone tissue engineering applications. On the other hand, very few research works investigate the effect of the sterilization processes on the properties of functionalized biomaterials. In this study, the effects of different sterilization techniques (e.g. gamma and electron beam irradiation, ethylene oxide) on the enzymatic activity of bioactive glasses and Ti6Al4V grafted with alkaline phosphatase (ALP) have been analyzed. Sterility maintenance and in vitro bioactivity of the sterilized surfaces have also been investigated. Finally the effect of packaging and storage conditions has been considered. (paper)

Performance Engineering Research Institute SciDAC-2 Enabling Technologies Institute Final Report

Energy Technology Data Exchange (ETDEWEB)

Hall, Mary [University of Utah

2014-09-19

Enhancing the performance of SciDAC applications on petascale systems has high priority within DOE SC. As we look to the future, achieving expected levels of performance on high-end com-puting (HEC) systems is growing ever more challenging due to enormous scale, increasing archi-tectural complexity, and increasing application complexity. To address these challenges, PERI has implemented a unified, tripartite research plan encompassing: (1) performance modeling and prediction; (2) automatic performance tuning; and (3) performance engineering of high profile applications. The PERI performance modeling and prediction activity is developing and refining performance models, significantly reducing the cost of collecting the data upon which the models are based, and increasing model fidelity, speed and generality. Our primary research activity is automatic tuning (autotuning) of scientific software. This activity is spurred by the strong user preference for automatic tools and is based on previous successful activities such as ATLAS, which has automatically tuned components of the LAPACK linear algebra library, and other re-cent work on autotuning domain-specific libraries. Our third major component is application en-gagement, to which we are devoting approximately 30% of our effort to work directly with Sci-DAC-2 applications. This last activity not only helps DOE scientists meet their near-term per-formance goals, but also helps keep PERI research focused on the real challenges facing DOE computational scientists as they enter the Petascale Era.

Pretreatment Engineering Platform Phase 1 Final Test Report

Energy Technology Data Exchange (ETDEWEB)

Kurath, Dean E.; Hanson, Brady D.; Minette, Michael J.; Baldwin, David L.; Rapko, Brian M.; Mahoney, Lenna A.; Schonewill, Philip P.; Daniel, Richard C.; Eslinger, Paul W.; Huckaby, James L.; Billing, Justin M.; Sundar, Parameshwaran S.; Josephson, Gary B.; Toth, James J.; Yokuda, Satoru T.; Baer, Ellen BK; Barnes, Steven M.; Golovich, Elizabeth C.; Rassat, Scot D.; Brown, Christopher F.; Geeting, John GH; Sevigny, Gary J.; Casella, Amanda J.; Bontha, Jagannadha R.; Aaberg, Rosanne L.; Aker, Pamela M.; Guzman-Leong, Consuelo E.; Kimura, Marcia L.; Sundaram, S. K.; Pires, Richard P.; Wells, Beric E.; Bredt, Ofelia P.

2009-12-23

Pacific Northwest National Laboratory (PNNL) was tasked by Bechtel National Inc. (BNI) on the River Protection Project, Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to conduct testing to demonstrate the performance of the WTP Pretreatment Facility (PTF) leaching and ultrafiltration processes at an engineering-scale. In addition to the demonstration, the testing was to address specific technical issues identified in Issue Response Plan for Implementation of External Flowsheet Review Team (EFRT) Recommendations - M12, Undemonstrated Leaching Processes.( ) Testing was conducted in a 1/4.5-scale mock-up of the PTF ultrafiltration system, the Pretreatment Engineering Platform (PEP). Parallel laboratory testing was conducted in various PNNL laboratories to allow direct comparison of process performance at an engineering-scale and a laboratory-scale. This report presents and discusses the results of those tests.

Pretreatment Engineering Platform Phase 1 Final Test Report

International Nuclear Information System (INIS)

Kurath, Dean E.; Hanson, Brady D.; Minette, Michael J.; Baldwin, David L.; Rapko, Brian M.; Mahoney, Lenna A.; Schonewill, Philip P.; Daniel, Richard C.; Eslinger, Paul W.; Huckaby, James L.; Billing, Justin M.; Sundar, Parameshwaran S.; Josephson, Gary B.; Toth, James J.; Yokuda, Satoru T.; Baer, Ellen B.K.; Barnes, Steven M.; Golovich, Elizabeth C.; Rassat, Scot D.; Brown, Christopher F.; Geeting, John G.H.; Sevigny, Gary J.; Casella, Amanda J.; Bontha, Jagannadha R.; Aaberg, Rosanne L.; Aker, Pamela M.; Guzman-Leong, Consuelo E.; Kimura, Marcia L.; Sundaram, S.K.; Pires, Richard P.; Wells, Beric E.; Bredt, Ofelia P.

2009-01-01

Pacific Northwest National Laboratory (PNNL) was tasked by Bechtel National Inc. (BNI) on the River Protection Project, Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to conduct testing to demonstrate the performance of the WTP Pretreatment Facility (PTF) leaching and ultrafiltration processes at an engineering-scale. In addition to the demonstration, the testing was to address specific technical issues identified in Issue Response Plan for Implementation of External Flowsheet Review Team (EFRT) Recommendations - M12, Undemonstrated Leaching Processes. Testing was conducted in a 1/4.5-scale mock-up of the PTF ultrafiltration system, the Pretreatment Engineering Platform (PEP). Parallel laboratory testing was conducted in various PNNL laboratories to allow direct comparison of process performance at an engineering-scale and a laboratory-scale. This report presents and discusses the results of those tests.

Application of an engineering inviscid-boundary layer method to slender three-dimensional vehicle forebodies

Science.gov (United States)

Riley, Christopher J.

1993-01-01

An engineering inviscid-boundary layer method has been modified for application to slender three-dimensional (3-D) forebodies which are characteristic of transatmospheric vehicles. An improved shock description in the nose region has been added to the inviscid technique which allows the calculation of a wider range of body geometries. The modified engineering method is applied to the perfect gas solution over a slender 3-D configuration at angle of attack. The method predicts surface pressures and laminar heating rates on the windward side of the vehicle that compare favorably with numerical solutions of the thin-layer Navier-Stokes equations. These improvements extend the 3-D capabilities of the engineering method and significantly increase its design applications.

Development of improved processing and evaluation methods for high reliability structural ceramics for advanced heat engine applications Phase II. Final report

Energy Technology Data Exchange (ETDEWEB)

Pujari, V.J.; Tracey, D.M.; Foley, M.R. [and others

1996-02-01

The research program had as goals the development and demonstration of significant improvements in processing methods, process controls, and nondestructive evaluation (NDE) which can be commercially implemented to produce high reliability silicon nitride components for advanced heat engine applications at temperatures to 1370{degrees}C. In Phase I of the program a process was developed that resulted in a silicon nitride - 4 w% yttria HIP`ed material (NCX 5102) that displayed unprecedented strength and reliability. An average tensile strength of 1 GPa and a strength distribution following a 3-parameter Weibull distribution were demonstrated by testing several hundred buttonhead tensile specimens. The Phase II program focused on the development of methodology for colloidal consolidation producing green microstructure which minimizes downstream process problems such as drying, shrinkage, cracking, and part distortion during densification. Furthermore, the program focused on the extension of the process to gas pressure sinterable (GPS) compositions. Excellent results were obtained for the HIP composition processed for minimal density gradients, both with respect to room-temperature strength and high-temperature creep resistance. Complex component fabricability of this material was demonstrated by producing engine-vane prototypes. Strength data for the GPS material (NCX-5400) suggest that it ranks very high relative to other silicon nitride materials in terms of tensile/flexure strength ratio, a measure of volume quality. This high quality was derived from the closed-loop colloidal process employed in the program.

Optical Measurement Techniques for Rocket Engine Testing and Component Applications: Digital Image Correlation and Dynamic Photogrammetry

Science.gov (United States)

Gradl, Paul

2016-01-01

NASA Marshall Space Flight Center (MSFC) has been advancing dynamic optical measurement systems, primarily Digital Image Correlation, for extreme environment rocket engine test applications. The Digital Image Correlation (DIC) technology is used to track local and full field deformations, displacement vectors and local and global strain measurements. This technology has been evaluated at MSFC through lab testing to full scale hotfire engine testing of the J-2X Upper Stage engine at Stennis Space Center. It has been shown to provide reliable measurement data and has replaced many traditional measurement techniques for NASA applications. NASA and AMRDEC have recently signed agreements for NASA to train and transition the technology to applications for missile and helicopter testing. This presentation will provide an overview and progression of the technology, various testing applications at NASA MSFC, overview of Army-NASA test collaborations and application lessons learned about Digital Image Correlation.

Near net shape, low cost ceramic valves for advanced engine applications

Energy Technology Data Exchange (ETDEWEB)

Pidria, M.; Merlone, E.; Parussa, F. [Fiat Research Centre, Orbassano (Italy); Handelsman, J.; Gorodnev, A. [Ceracom Materials Ltd., Yavneh (Israel)

2003-07-01

Future gasoline and diesel engines with electro-hydraulic or electro-mechanical valve control systems require the development of lighter valves to achieve the best results in terms of increased performances, lower fuel consumption and overall efficiency. Ceramic materials can adequately satisfy the required mechanical and thermal properties, nevertheless they still lack as far as manufacturing costs are concerned. Objective of the work was the development of a low-cost forming and sintering process, to produce near-net shape ceramic valves thus requiring very low finishing operations and significantly minimizing material waste. Between available technical ceramic materials, silicon nitride has been chosen to replace conventional steels and Ni-based alloys for the exhaust valves application. The work was then devoted to (i) the selection of the best starting materials composition, taking into account the requirements of a cost effective and high volume production, (ii) the development of an innovative pressure-injection molding process to produce near-net shape parts via a thermosetting feedstock and (iii) the optimization of a proper pressure-less sintering route to obtain cost-competitive, real scale components with adequate final density and mechanical properties. (orig.)

Engineering the Surface/Interface Structures of Titanium Dioxide Micro and Nano Architectures towards Environmental and Electrochemical Applications

DEFF Research Database (Denmark)

Wang, Xiaoliang; Zhao, Yanyan; Mølhave, Kristian

2017-01-01

advances in the surface and interface engineering and applications in environmental and electrochemical applications. We analyze the advantages of surface/interface engineered TiO₂ micro and nano structures, and present the principles and growth mechanisms of TiO₂ nanostructures via different strategies...

A Review of Distributed Optical Fiber Sensors for Civil Engineering Applications

Science.gov (United States)

Barrias, António; Casas, Joan R.; Villalba, Sergi

2016-01-01

The application of structural health monitoring (SHM) systems to civil engineering structures has been a developing studied and practiced topic, that has allowed for a better understanding of structures’ conditions and increasingly lead to a more cost-effective management of those infrastructures. In this field, the use of fiber optic sensors has been studied, discussed and practiced with encouraging results. The possibility of understanding and monitor the distributed behavior of extensive stretches of critical structures it’s an enormous advantage that distributed fiber optic sensing provides to SHM systems. In the past decade, several R & D studies have been performed with the goal of improving the knowledge and developing new techniques associated with the application of distributed optical fiber sensors (DOFS) in order to widen the range of applications of these sensors and also to obtain more correct and reliable data. This paper presents, after a brief introduction to the theoretical background of DOFS, the latest developments related with the improvement of these products by presenting a wide range of laboratory experiments as well as an extended review of their diverse applications in civil engineering structures. PMID:27223289

A Review of Distributed Optical Fiber Sensors for Civil Engineering Applications.

Science.gov (United States)

Barrias, António; Casas, Joan R; Villalba, Sergi

2016-05-23

The application of structural health monitoring (SHM) systems to civil engineering structures has been a developing studied and practiced topic, that has allowed for a better understanding of structures' conditions and increasingly lead to a more cost-effective management of those infrastructures. In this field, the use of fiber optic sensors has been studied, discussed and practiced with encouraging results. The possibility of understanding and monitor the distributed behavior of extensive stretches of critical structures it's an enormous advantage that distributed fiber optic sensing provides to SHM systems. In the past decade, several R & D studies have been performed with the goal of improving the knowledge and developing new techniques associated with the application of distributed optical fiber sensors (DOFS) in order to widen the range of applications of these sensors and also to obtain more correct and reliable data. This paper presents, after a brief introduction to the theoretical background of DOFS, the latest developments related with the improvement of these products by presenting a wide range of laboratory experiments as well as an extended review of their diverse applications in civil engineering structures.

A Review of Distributed Optical Fiber Sensors for Civil Engineering Applications

Directory of Open Access Journals (Sweden)

António Barrias

2016-05-01

Full Text Available The application of structural health monitoring (SHM systems to civil engineering structures has been a developing studied and practiced topic, that has allowed for a better understanding of structures’ conditions and increasingly lead to a more cost-effective management of those infrastructures. In this field, the use of fiber optic sensors has been studied, discussed and practiced with encouraging results. The possibility of understanding and monitor the distributed behavior of extensive stretches of critical structures it’s an enormous advantage that distributed fiber optic sensing provides to SHM systems. In the past decade, several R & D studies have been performed with the goal of improving the knowledge and developing new techniques associated with the application of distributed optical fiber sensors (DOFS in order to widen the range of applications of these sensors and also to obtain more correct and reliable data. This paper presents, after a brief introduction to the theoretical background of DOFS, the latest developments related with the improvement of these products by presenting a wide range of laboratory experiments as well as an extended review of their diverse applications in civil engineering structures.

Introduction to tissue engineering and application for cartilage engineering.

Science.gov (United States)

de Isla, N; Huseltein, C; Jessel, N; Pinzano, A; Decot, V; Magdalou, J; Bensoussan, D; Stoltz, J-F

2010-01-01

Tissue engineering is a multidisciplinary field that applies the principles of engineering, life sciences, cell and molecular biology toward the development of biological substitutes that restore, maintain, and improve tissue function. In Western Countries, tissues or cells management for clinical uses is a medical activity governed by different laws. Three general components are involved in tissue engineering: (1) reparative cells that can form a functional matrix; (2) an appropriate scaffold for transplantation and support; and (3) bioreactive molecules, such as cytokines and growth factors that will support and choreograph formation of the desired tissue. These three components may be used individually or in combination to regenerate organs or tissues. Thus the growing development of tissue engineering needs to solve four main problems: cells, engineering development, grafting and safety studies.

Nonparametric statistics with applications to science and engineering

CERN Document Server

Kvam, Paul H

2007-01-01

A thorough and definitive book that fully addresses traditional and modern-day topics of nonparametric statistics This book presents a practical approach to nonparametric statistical analysis and provides comprehensive coverage of both established and newly developed methods. With the use of MATLAB, the authors present information on theorems and rank tests in an applied fashion, with an emphasis on modern methods in regression and curve fitting, bootstrap confidence intervals, splines, wavelets, empirical likelihood, and goodness-of-fit testing. Nonparametric Statistics with Applications to Science and Engineering begins with succinct coverage of basic results for order statistics, methods of categorical data analysis, nonparametric regression, and curve fitting methods. The authors then focus on nonparametric procedures that are becoming more relevant to engineering researchers and practitioners. The important fundamental materials needed to effectively learn and apply the discussed methods are also provide...

Sound engineering for diesel engines; Sound Engineering an Dieselmotoren

Energy Technology Data Exchange (ETDEWEB)

Enderich, A.; Fischer, R. [MAHLE Filtersysteme GmbH, Stuttgart (Germany)

2006-07-01

The strong acceptance for vehicles powered by turbo-charged diesel engines encourages several manufacturers to think about sportive diesel concepts. The approach of suppressing unpleasant noise by the application of distinctive insulation steps is not adequate to satisfy sportive needs. The acoustics cannot follow the engine's performance. This report documents, that it is possible to give diesel-powered vehicles a sportive sound characteristic by using an advanced MAHLE motor-sound-system with a pressure-resistant membrane and an integrated load controlled flap. With this the specific acoustic disadvantages of the diesel engine, like the ''diesel knock'' or a rough engine running can be masked. However, by the application of a motor-sound-system you must not negate the original character of the diesel engine concept, but accentuate its strong torque characteristic in the middle engine speed range. (orig.)

[Progress of research on genetic engineering antibody and its application in prevention and control of parasitic diseases].

Science.gov (United States)

Yao, Yuan; Yu, Chuan-xin

2013-08-01

Antibody has extensive application prospects in the biomedical field. The inherent disadvantages of traditional polyclonal antibody and monoclonal antibody limit their application values. The humanized and fragmented antibody remodeling has given a rise to a series of genetic engineered antibody variant. This paper reviews the progress of research on genetic engineering antibody and its application in prevention and control of parasitic diseases.

Knowledge and Technology Transfer in Materials Science and Engineering in Europe

OpenAIRE

Bressler, Patrick; Dürig, Urs; González-Elipe, Agustin; Quandt, Eckhard; Ritschkoff, Anne-Christine; Vahlas, Constantin

2015-01-01

Advanced Materials is one of the Key Enabling 3 Technologies identified by the European Commission1. Together with Advanced Manufacturing it underpins almost all other Key Enabling and Industrial Technologies. The basic science and engineering research that results in the development of Advanced Materials lies within the field of Materials Science and Engineering (MSE). The transfer of knowledge from basic research into final products and applications in the field of MSE involves certain MSE-...

Review of the Space Mapping Approach to Engineering Optimization and Modeling

DEFF Research Database (Denmark)

Bakr, M. H.; Bandler, J. W.; Madsen, Kaj

2000-01-01

We review the Space Mapping (SM) concept and its applications in engineering optimization and modeling. The aim of SM is to avoid computationally expensive calculations encountered in simulating an engineering system. The existence of less accurate but fast physically-based models is exploited. S......-based Modeling (SMM). These include Space Derivative Mapping (SDM), Generalized Space Mapping (GSM) and Space Mapping-based Neuromodeling (SMN). Finally, we address open points for research and future development....

Development and application of laser techniques for studying fuel dynamics and NO formation in engines

Energy Technology Data Exchange (ETDEWEB)

Andersson, Oeivind

2000-11-01

In this work a number of laser techniques have been applied in new ways for combustion diagnostics in engines. The applications cover small two-stroke engines, ordinary spark ignition (SI) engines, direct-injection spark ignition (DISI) engines, and heavy-duty diesel truck engines. In an investigation of unmodified two-stroke engines running at high engine speed, it has been shown that cycle-resolved laser diagnostics are applicable to real-world engines. The emission of unburned fuel was detected at the exhaust port with successful discrimination against other unburned hydrocarbons. Although a few problems remain to be solved in order to get quantitative concentration data, valuable information can nonetheless be attained using this technique. The technique would benefit from the use of a non-fluorescing lubricant, as that would decrease the background fluorescence. Laser-based techniques also provide a useful tool for studying the fuel dynamics inside the cylinder. In the development of DISI engines it is of particular importance to acquire knowledge about the distribution of fuel around the spark plug. Numerical computer codes are often used as design tools in these applications. Laser techniques are capable of yielding instantaneous multi-point concentration information with high spatial and temporal resolution, making them ideal both for validation of CFD simulations and for testing designs. The feasibility of using laser diagnostics in the development of DISI engines has been shown. Future research should be aimed at simplifying the procedure for quantifying the data, since a fairly simple and reliable technique would be an important asset for the industry. In a more fundamental study, it has been shown that it is possible to simultaneously detect a substance in both liquid and vapour phase. Water was used in the study since it is easily produced in both phases. Liquid drops were detected using spontaneous Raman scattering, whereas the vapour surrounding them

Development and application of laser techniques for studying fuel dynamics and NO formation in engines

Energy Technology Data Exchange (ETDEWEB)

Andersson, Oeivind

2000-11-01

In this work a number of laser techniques have been applied in new ways for combustion diagnostics in engines. The applications cover small two-stroke engines, ordinary spark ignition (SI) engines, direct-injection spark ignition (DISI) engines, and heavy-duty diesel truck engines. In an investigation of unmodified two-stroke engines running at high engine speed, it has been shown that cycle-resolved laser diagnostics are applicable to real-world engines. The emission of unburned fuel was detected at the exhaust port with successful discrimination against other unburned hydrocarbons. Although a few problems remain to be solved in order to get quantitative concentration data, valuable information can nonetheless be attained using this technique. The technique would benefit from the use of a non-fluorescing lubricant, as that would decrease the background fluorescence. Laser-based techniques also provide a useful tool for studying the fuel dynamics inside the cylinder. In the development of DISI engines it is of particular importance to acquire knowledge about the distribution of fuel around the spark plug. Numerical computer codes are often used as design tools in these applications. Laser techniques are capable of yielding instantaneous multi-point concentration information with high spatial and temporal resolution, making them ideal both for validation of CFD simulations and for testing designs. The feasibility of using laser diagnostics in the development of DISI engines has been shown. Future research should be aimed at simplifying the procedure for quantifying the data, since a fairly simple and reliable technique would be an important asset for the industry. In a more fundamental study, it has been shown that it is possible to simultaneously detect a substance in both liquid and vapour phase. Water was used in the study since it is easily produced in both phases. Liquid drops were detected using spontaneous Raman scattering, whereas the vapour surrounding them

Introduction to Integral Calculus Systematic Studies with Engineering Applications for Beginners

CERN Document Server

Rohde, Ulrich L; Poddar, Ajay K; Ghosh, A K

2011-01-01

An accessible introduction to the fundamentals of calculus needed to solve current problems in engineering and the physical sciences I ntegration is an important function of calculus, and Introduction to Integral Calculus combines fundamental concepts with scientific problems to develop intuition and skills for solving mathematical problems related to engineering and the physical sciences. The authors provide a solid introduction to integral calculus and feature applications of integration, solutions of differential equations, and evaluation methods. With logical organization coupled with cle

Use of neural networks in process engineering. Thermodynamics, diffusion, and process control and simulation applications

International Nuclear Information System (INIS)

Otero, F

1998-01-01

This article presents the current status of the use of Artificial Neural Networks (ANNs) in process engineering applications where common mathematical methods do not completely represent the behavior shown by experimental observations, results, and plant operating data. Three examples of the use of ANNs in typical process engineering applications such as prediction of activity in solvent-polymer binary systems, prediction of a surfactant self-diffusion coefficient of micellar systems, and process control and simulation are shown. These examples are important for polymerization applications, enhanced-oil recovery, and automatic process control

The Application of Hardware in the Loop Testing for Distributed Engine Control

Science.gov (United States)

Thomas, George L.; Culley, Dennis E.; Brand, Alex

2016-01-01

The essence of a distributed control system is the modular partitioning of control function across a hardware implementation. This type of control architecture requires embedding electronics in a multitude of control element nodes for the execution of those functions, and their integration as a unified system. As the field of distributed aeropropulsion control moves toward reality, questions about building and validating these systems remain. This paper focuses on the development of hardware-in-the-loop (HIL) test techniques for distributed aero engine control, and the application of HIL testing as it pertains to potential advanced engine control applications that may now be possible due to the intelligent capability embedded in the nodes.

Engineering and Application of Zinc Finger Proteins and TALEs for Biomedical Research.

Science.gov (United States)

Kim, Moon-Soo; Kini, Anu Ganesh

2017-08-01

Engineered DNA-binding domains provide a powerful technology for numerous biomedical studies due to their ability to recognize specific DNA sequences. Zinc fingers (ZF) are one of the most common DNA-binding domains and have been extensively studied for a variety of applications, such as gene regulation, genome engineering and diagnostics. Another novel DNA-binding domain known as a transcriptional activator-like effector (TALE) has been more recently discovered, which has a previously undescribed DNA-binding mode. Due to their modular architecture and flexibility, TALEs have been rapidly developed into artificial gene targeting reagents. Here, we describe the methods used to design these DNA-binding proteins and their key applications in biomedical research.

Software engineering processes principles and applications

CERN Document Server

Wang, Yingxu

2000-01-01

Fundamentals of the Software Engineering ProcessIntroductionA Unified Framework of the Software Engineering ProcessProcess AlgebraProcess-Based Software EngineeringSoftware Engineering Process System ModelingThe CMM ModelThe ISO 9001 ModelThe BOOTSTRAP ModelThe ISO/IEC 15504 (SPICE) ModelThe Software Engineering Process Reference Model: SEPRMSoftware Engineering Process System AnalysisBenchmarking the SEPRM ProcessesComparative Analysis of Current Process ModelsTransformation of Capability Levels Between Current Process ModelsSoftware Engineering Process EstablishmentSoftware Process Establish

9th International Conference on Software Engineering Research, Management and Applications(SERA 2011)

CERN Document Server

Software Engineering Research, Management and Applications 2011

2012-01-01

The purpose of the 9th International Conference on Software Engineering Research, Management and Applications(SERA 2011) held on August 10-12, 2011 in Baltimore, Maryland was to bring together scientists, engineers, computer users, and students to share their experiences and exchange new ideas and research results about all aspects (theory, applications and tools) of computer and information sciences, and to discuss the practical challenges encountered along the way and the solutions adopted to solve them.   The conference organizers selected 12 outstanding papers from SERA 2011, all of which you will find in this volume of Springer’s Studies in Computational Intelligence.

Tissue engineering in dentistry.

Science.gov (United States)

Abou Neel, Ensanya Ali; Chrzanowski, Wojciech; Salih, Vehid M; Kim, Hae-Won; Knowles, Jonathan C

2014-08-01

of this review is to inform practitioners with the most updated information on tissue engineering and its potential applications in dentistry. The authors used "PUBMED" to find relevant literature written in English and published from the beginning of tissue engineering until today. A combination of keywords was used as the search terms e.g., "tissue engineering", "approaches", "strategies" "dentistry", "dental stem cells", "dentino-pulp complex", "guided tissue regeneration", "whole tooth", "TMJ", "condyle", "salivary glands", and "oral mucosa". Abstracts and full text articles were used to identify causes of craniofacial tissue loss, different approaches for craniofacial reconstructions, how the tissue engineering emerges, different strategies of tissue engineering, biomaterials employed for this purpose, the major attempts to engineer different dental structures, finally challenges and future of tissue engineering in dentistry. Only those articles that dealt with the tissue engineering in dentistry were selected. There have been a recent surge in guided tissue engineering methods to manage periodontal diseases beyond the traditional approaches. However, the predictable reconstruction of the innate organisation and function of whole teeth as well as their periodontal structures remains challenging. Despite some limited progress and minor successes, there remain distinct and important challenges in the development of reproducible and clinically safe approaches for oral tissue repair and regeneration. Clearly, there is a convincing body of evidence which confirms the need for this type of treatment, and public health data worldwide indicates a more than adequate patient resource. The future of these therapies involving more biological approaches and the use of dental tissue stem cells is promising and advancing. Also there may be a significant interest of their application and wider potential to treat disorders beyond the craniofacial region. Considering the

Engineering Metal Nanostructure for SERS Application

Directory of Open Access Journals (Sweden)

Yanqin Cao

2013-01-01

Full Text Available Surface-enhanced Raman scattering (SERS has attracted great attention due to its remarkable enhancement and excellent selectivity in the detection of various molecules. Noble metal nanomaterials have usually been employed for producing substrates that can be used in SERS because of their unique local plasma resonance. As the SERS enhancement of signals depends on parameters such as size, shape, morphology, arrangement, and dielectric environment of the nanostructure, there have been a number of studies on tunable nanofabrication and synthesis of noble metals. In this work, we will illustrate progress in engineering metallic nanostructures with various morphologies using versatile methods. We also discuss their SERS applications in different fields and the challenges.

Implementation of knowledge-based engineering methodology in hydraulic generator design

Directory of Open Access Journals (Sweden)

Wei Guo

2015-05-01

Full Text Available Hydraulic generator design companies are always being exhorted to become more competitive by reducing the lead time and costs for their products for survival. Knowledge-based engineering technology is a rapidly developing technology with competitive advantage for design application to reduce time and cost in product development. This article addresses the structure of the hydraulic generator design system based on the knowledge-based engineering technology in detail. The system operates by creating a unified knowledge base to store the scattered knowledge among the whole life of the design process, which was contained in the expert’s brain and technical literature. It helps designers to make appropriate decisions by supplying necessary information at the right time through query and inference engine to represent the knowledge within the knowledge-based engineering application framework. It also integrates the analysis tools into one platform to help achieve global optimum solutions. Finally, an example of turbine-type selection was given to illustrate the operation process and prove its validity.

Advancing metabolic engineering through systems biology of industrial microorganisms

DEFF Research Database (Denmark)

Dai, Zongjie; Nielsen, Jens

2015-01-01

resources. The objective of systems biology is to gain a comprehensive and quantitative understanding of living cells and can hereby enhance our ability to characterize and predict cellular behavior. Systems biology of industrial microorganisms is therefore valuable for metabolic engineering. Here we review......Development of sustainable processes to produce bio-based compounds is necessary due to the severe environmental problems caused by the use of fossil resources. Metabolic engineering can facilitate the development of highly efficient cell factories to produce these compounds from renewable...... the application of systems biology tools for the identification of metabolic engineering targets which may lead to reduced development time for efficient cell factories. Finally, we present some perspectives of systems biology for advancing metabolic engineering further....

Engineering Support for Handling Controller Conflicts in Energy Storage Systems Applications

Directory of Open Access Journals (Sweden)

Claudia Zanabria

2017-10-01

Full Text Available Energy storage systems will play a major role in the decarbonization of future sustainable electric power systems, allowing a high penetration of distributed renewable energy sources and contributing to the distribution network stability and reliability. To accomplish this, a storage system is required to provide multiple services such as self-consumption, grid support, peak-shaving, etc. The simultaneous activation of controllers operation may lead to conflicts, as a consequence the execution of committed services is not guaranteed. This paper presents and discusses a solution to the exposed issue by developing an engineering support approach to semi-automatically detect and handle conflicts for multi-usage storage systems applications. To accomplish that an ontology is developed and exploited by model-driven engineering mechanisms. The proposed approach is evaluated by implementing a use case example, where detection of conflicts is automatically done at an early design stage. Besides this, exploitable source code for conflicts resolution is generated and used during the design and prototype stages of controllers development. Thus, the proposed engineering support enhances the design and development of storage system controllers, especially for multi-usage applications.

Grouting applications in civil engineering. Volume I and II. [800 references

Energy Technology Data Exchange (ETDEWEB)

Einstein, H.H.; Barvenik, M.J.

1975-01-01

A comprehensive description of grouting applications in civil engineering is presented that can serve as a basis for the selection of grouting methods in the borehole sealing problem. The breadth and depth of the study was assured by conducting the main part of the review, the collection and evaluation of information, without specifically considering the borehole sealing problem (but naturally incorporating any aspect of civil engineering applications that could be of potential use). Grouting is very much an art and not a science. In most cases, it is a trial and error procedure where an inexpensive method is initially tried and then a more expensive one is used until the desired results are obtained. Once a desired effect is obtained, it is difficult to credit any one procedure with the success because the results are due to the summation of all the methods used. In many cases, the method that proves successful reflects a small abnormality in the ground or structure rather than its overall characteristics. Hence, successful grouting relies heavily on good engineering judgement and experience, and not on a basic set of standard correlations or equations. 800 references. (JRD)

Finally, nuclear engineering textbooks with a Canadian flavour!

International Nuclear Information System (INIS)

Bonin, H.W.

2002-01-01

The need for nuclear engineering textbooks more appropriate to the Canadian nuclear industry context and the CANDU nuclear reactor program has long been felt not only among the universities offering nuclear engineering programs at the graduate level, but also within the Canadian nuclear industry itself. Coverage of the CANDU reactor system in the textbooks presently supporting teaching is limited to a brief description of the concept. Course instructors usually complement these textbooks with course notes written from their personal experience from past employment within the nuclear industry and from their research interests In the last ten years, the Canadian nuclear industry has been involved on an increasing basis with the issue of the technology transfer to foreign countries which have purchased CANDU reactors or have been in the process of purchasing one or several CANDUs. For some of these countries, the 'turn key' approach is required, in which the Canadian nuclear industry looks after everything up to the commissioning of the nuclear power plant, including the education and training of local nuclear engineers and plant personnel. Atomic Energy of Canada Limited (AECL) in particular has dispatched some personnel tasked to prepare and give short courses on some specific aspects of CANDU design and operation, but a lack of consistency was observed as different persons prepared and gave the courses rather independently. To address the many problems tied with nuclear engineering education, the CANTEACH program was set up involving major partners of the Canadian nuclear industry. Parts of the activities foreseen by CANTEACH consist in the writing of nuclear engineering textbooks and associated computer-based pedagogical material. The present paper discusses the main parts of two textbooks being produced, one in reactor physics at steady state and the other on nuclear fuel management. (author)

Applications of computational modeling in metabolic engineering of yeast.

Science.gov (United States)

Kerkhoven, Eduard J; Lahtvee, Petri-Jaan; Nielsen, Jens

2015-02-01

Generally, a microorganism's phenotype can be described by its pattern of metabolic fluxes. Although fluxes cannot be measured directly, inference of fluxes is well established. In biotechnology the aim is often to increase the capacity of specific fluxes. For this, metabolic engineering methods have been developed and applied extensively. Many of these rely on balancing of intracellular metabolites, redox, and energy fluxes, using genome-scale models (GEMs) that in combination with appropriate objective functions and constraints can be used to predict potential gene targets for obtaining a preferred flux distribution. These methods point to strategies for altering gene expression; however, fluxes are often controlled by post-transcriptional events. Moreover, GEMs are usually not taking into account metabolic regulation, thermodynamics and enzyme kinetics. To facilitate metabolic engineering, tools from synthetic biology have emerged, enabling integration and assembly of naturally nonexistent, but well-characterized components into a living organism. To describe these systems kinetic models are often used and to integrate these systems with the standard metabolic engineering approach, it is necessary to expand the modeling of metabolism to consider kinetics of individual processes. This review will give an overview about models available for metabolic engineering of yeast and discusses their applications. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

Teaching-Learning-Based Optimization with Learning Enthusiasm Mechanism and Its Application in Chemical Engineering

Directory of Open Access Journals (Sweden)

Xu Chen

2018-01-01

Full Text Available Teaching-learning-based optimization (TLBO is a population-based metaheuristic search algorithm inspired by the teaching and learning process in a classroom. It has been successfully applied to many scientific and engineering applications in the past few years. In the basic TLBO and most of its variants, all the learners have the same probability of getting knowledge from others. However, in the real world, learners are different, and each learner’s learning enthusiasm is not the same, resulting in different probabilities of acquiring knowledge. Motivated by this phenomenon, this study introduces a learning enthusiasm mechanism into the basic TLBO and proposes a learning enthusiasm based TLBO (LebTLBO. In the LebTLBO, learners with good grades have high learning enthusiasm, and they have large probabilities of acquiring knowledge from others; by contrast, learners with bad grades have low learning enthusiasm, and they have relative small probabilities of acquiring knowledge from others. In addition, a poor student tutoring phase is introduced to improve the quality of the poor learners. The proposed method is evaluated on the CEC2014 benchmark functions, and the computational results demonstrate that it offers promising results compared with other efficient TLBO and non-TLBO algorithms. Finally, LebTLBO is applied to solve three optimal control problems in chemical engineering, and the competitive results show its potential for real-world problems.

The use of application-specific performance targets and engineering considerations to guide hydrogen storage materials development

Energy Technology Data Exchange (ETDEWEB)

Stetson, Ned T., E-mail: ned.stetson@ee.doe.gov [U.S. Department of Energy, 1000 Independence Ave., SW, EE-2H, Washington, DC 20585 (United States); Ordaz, Grace; Adams, Jesse; Randolph, Katie [U.S. Department of Energy, 1000 Independence Ave., SW, EE-2H, Washington, DC 20585 (United States); McWhorter, Scott [Savannah River National Laboratory, Aiken, SC 29808 (United States)

2013-12-15

Highlights: •Portable power and material handling equipment as early market technology pathways. •Engineering based system-level storage-materials requirements. •Application based targets. -- Abstract: The Hydrogen and Fuel Cells Technologies Office, carried out through the DOE Office of Energy Efficiency and Renewable Energy, maintains a broad portfolio of activities to enable the commercialization of fuel cells across a range of near, mid and long-term applications. Improved, advanced hydrogen storage technologies are seen as a critical need for successful implementation of hydrogen fuel cells in many of these applications. To guide and focus materials development efforts, the DOE develops system performance targets for the specific applications of interest, and carries out system engineering analyses to determine the system-level performance delivered when the materials are incorporated into a complete system. To meet the needs of applications, it is important to consider the system-level performance, not just the material-level properties. An overview of the DOE’s hydrogen storage efforts in developing application-specific performance targets and systems engineering to guide hydrogen storage materials identification and development is herein provided.

The use of application-specific performance targets and engineering considerations to guide hydrogen storage materials development

International Nuclear Information System (INIS)

Stetson, Ned T.; Ordaz, Grace; Adams, Jesse; Randolph, Katie; McWhorter, Scott

2013-01-01

Highlights: •Portable power and material handling equipment as early market technology pathways. •Engineering based system-level storage-materials requirements. •Application based targets. -- Abstract: The Hydrogen and Fuel Cells Technologies Office, carried out through the DOE Office of Energy Efficiency and Renewable Energy, maintains a broad portfolio of activities to enable the commercialization of fuel cells across a range of near, mid and long-term applications. Improved, advanced hydrogen storage technologies are seen as a critical need for successful implementation of hydrogen fuel cells in many of these applications. To guide and focus materials development efforts, the DOE develops system performance targets for the specific applications of interest, and carries out system engineering analyses to determine the system-level performance delivered when the materials are incorporated into a complete system. To meet the needs of applications, it is important to consider the system-level performance, not just the material-level properties. An overview of the DOE’s hydrogen storage efforts in developing application-specific performance targets and systems engineering to guide hydrogen storage materials identification and development is herein provided

Elements of quantum computing history, theories and engineering applications

CERN Document Server

Akama, Seiki

2015-01-01

A quantum computer is a computer based on a computational model which uses quantum mechanics, which is a subfield of physics to study phenomena at the micro level. There has been a growing interest on quantum computing in the 1990's, and some quantum computers at the experimental level were recently implemented. Quantum computers enable super-speed computation, and can solve some important problems whose solutions were regarded impossible or intractable with traditional computers. This book provides a quick introduction to quantum computing for readers who have no backgrounds of both theory of computation and quantum mechanics. “Elements of Quantum Computing” presents the history, theories, and engineering applications of quantum computing. The book is suitable to computer scientists, physicist, and software engineers.

Application of smart transmitter technology in nuclear engineering measurements

International Nuclear Information System (INIS)

Kang, Hyun Gook; Seong, Poong Hyun

1993-01-01

By making use of the microprocessor technology, instrumentation system becomes intelligent. In this study a programmable smart transmitter is designed and applied to the nuclear engineering measurements. In order to apply the smart transmitter technology to nuclear engineering measurements, the digital time delay compensation function and water level change detection function are developed and applied in this work. The time compensation function compensates effectively the time delay of the measured signal, but it is found that the characteristics of the compensation function should be considered through its application. It is also found that the water level change detection function reduces the detection time to about 7 seconds by the signal processing which has the time constant of over 250 seconds and which has the heavy noise. (Author)

Application of integrated computer-aided engineering for design, construction and operation of nuclear power plant

International Nuclear Information System (INIS)

Kyung-shick Min; Byung-hun Lee

1987-01-01

Computer-aided-engineering (CAE) is an essential tool for modern nuclear power plant engineering. It greatly varies in definition, application, and technology from project to project and company to company. Despite the fast growing technologies and applications of CAE, its complexty and variety have thrown aonther puzzle to management of a nuclear project. Without due consideration of an integrated CAE system in early planning stage, the overall efficiency of a nuclear project would slow down due to the inefficiency in data flow. In this paper, practices and perspectives of CAE appliation are discussed under the Korea Power Engineering Company (KOPEC) philosophy in CAE approach. (author)

Current progress of targetron technology: development, improvement and application in metabolic engineering.

Science.gov (United States)

Liu, Ya-Jun; Zhang, Jie; Cui, Gu-Zhen; Cui, Qiu

2015-06-01

Targetrons are mobile group II introns that can recognize their DNA target sites by base-pairing RNA-DNA interactions with the aid of site-specific binding reverse transcriptases. Targetron technology stands out from recently developed gene targeting methods because of the flexibility, feasibility, and efficiency, and is particularly suitable for the genetic engineering of difficult microorganisms, including cellulolytic bacteria that are considered promising candidates for biomass conversion via consolidated bioprocessing. Along with the development of the thermotargetron method for thermophiles, targetron technology becomes increasingly important for the metabolic engineering of industrial microorganisms aiming at biofuel/chemical production. To summarize the current progress of targetron technology and provide new insights on the use of the technology, this paper reviews the retrohoming mechanisms of both mesophilic and thermophilic targetron methods based on various group II introns, investigates the improvement of targetron tools for high target efficiency and specificity, and discusses the current applications in the metabolic engineering for bacterial producers. Although there are still intellectual property and technical restrictions in targetron applications, we propose that targetron technology will contribute to both biochemistry research and the metabolic engineering for industrial productions. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

High Pressure Reverse Flow APS Engine

Science.gov (United States)

Senneff, J. M.

1972-01-01

A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

Bio-engineering for land stabilization : final report.

Science.gov (United States)

2010-06-01

As part of the Ohio Department of Transportations (ODOTs) ongoing effort to solve engineering problems for the Ohio : transportation system through research, The Ohio State University has undertaken a study entitled Bioengineering for : Land...

TMI-2 instrumentation and electrical program final evaluation report

International Nuclear Information System (INIS)

Mayo, C.W.; Huzdovich, J.W.; Roby, A.R.; Test, L.D.

1986-11-01

This report presents the authors collective opinions on the value to the nuclear industry of the various investigations performed at TMI-2 by the Instrumentation and Electrical Program. The authors demonstrate that more attention must be given to the prevention of moisture intrusion during design, construction, operation, and maintenance of a nuclear power plant. They also point out that, while basic engineering designs of instruments are more than adequate, the applications engineering and specifications could be improved. Finally, they show that advanced testing technology, exemplified by the Electrical Circuit Characterization and Diagnostics (ECCAD) System, may be very useful as a diagnostic tool when used as part of the testing or maintenance program in a nuclear power plant

Applications of laser diagnostics to thermal power plants and engines

International Nuclear Information System (INIS)

Deguchi, Y.; Kamimoto, T.; Wang, Z.Z.; Yan, J.J.; Liu, J.P.; Watanabe, H.; Kurose, R.

2014-01-01

The demands for lowering the burdens on the environment will continue to grow steadily. It is important to monitor controlling factors in order to improve the operation of industrial thermal systems. In engines, exhaust gas temperature and concentration distributions are important factors in nitrogen oxides (NO x ), total hydrocarbon (THC) and particulate matter (PM) emissions. Coal and fly ash contents are parameters which can be used for the control of coal-fired thermal power plants. Monitoring of heavy metals such as Hg is also important for pollution control. In this study, the improved laser measurement techniques using computed tomography-tunable diode laser absorption spectroscopy (CT-TDLAS), low pressure laser-induced breakdown spectroscopy (LIBS), and laser breakdown time-of-flight mass spectrometry (LB-TOFMS) have been developed and applied to measure 2D temperature and species concentrations in engine exhausts, coal and fly ash contents, and trace species measurement. The 2D temperature and NH 3 concentration distributions in engine exhausts were successfully measured using CT-TDLAS. The elemental contents of size-segregated particles were measured and the signal stability increased using LIBS with the temperature correction method. The detection limit of trace species measurement was enhanced using low pressure LIBS and LB-TOFMS. The detection limit of Hg can be enhanced to 3.5 ppb when employing N 2 as the buffer gas using low pressure LIBS. Hg detection limit was about 0.82 ppb using 35 ps LB-TOFMS. Compared to conventional measurement methods laser diagnostics has high sensitivity, high response and non-contact features for actual industrial systems. With these engineering developments, transient phenomena such as start-ups in thermal systems can be evaluated to improve the efficiency of these thermal processes. - Highlights: • Applicability of newly developed laser diagnostics was demonstrated for the improvement of thermal power plants and

Analytical and experimental evaluation of joining silicon carbide to silicon carbide and silicon nitride to silicon nitride for advanced heat engine applications Phase 2. Final report

Energy Technology Data Exchange (ETDEWEB)

Sundberg, G.J.; Vartabedian, A.M.; Wade, J.A.; White, C.S. [Norton Co., Northboro, MA (United States). Advanced Ceramics Div.

1994-10-01

The purpose of joining, Phase 2 was to develop joining technologies for HIP`ed Si{sub 3}N{sub 4} with 4wt% Y{sub 2}O{sub 3} (NCX-5101) and for a siliconized SiC (NT230) for various geometries including: butt joins, curved joins and shaft to disk joins. In addition, more extensive mechanical characterization of silicon nitride joins to enhance the predictive capabilities of the analytical/numerical models for structural components in advanced heat engines was provided. Mechanical evaluation were performed by: flexure strength at 22 C and 1,370 C, stress rupture at 1,370 C, high temperature creep, 22 C tensile testing and spin tests. While the silicon nitride joins were produced with sufficient integrity for many applications, the lower join strength would limit its use in the more severe structural applications. Thus, the silicon carbide join quality was deemed unsatisfactory to advance to more complex, curved geometries. The silicon carbide joining methods covered within this contract, although not entirely successful, have emphasized the need to focus future efforts upon ways to obtain a homogeneous, well sintered parent/join interface prior to siliconization. In conclusion, the improved definition of the silicon carbide joining problem obtained by efforts during this contract have provided avenues for future work that could successfully obtain heat engine quality joins.

HCCI Combustion Engines Final Report CRADA No. TC02032.0

Energy Technology Data Exchange (ETDEWEB)

Aceves, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lyford-Pike, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-09-08

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Livermore National Laboratory (LLNL) and Cummins Engine Company (Cwnmins), to advance the state of the art on HomogeneousCharge Compression-Ignition (HCCI) engines, resulting in a clean, high-efficiency alternative to diesel engines.

Synthetic scaffolds based on biodegradable, functionalized polyesters for tissue engineering applications

NARCIS (Netherlands)

Seyednejad, S.H.

2012-01-01

The aim of this thesis was to investigate the possibility of using a novel hydroxyl-functionalized polyester [poly(hydroxymethylglycolide-co-ε-caprolactone), pHMGCL] (Fig.9) to fabricate scaffolds for tissue engineering applications. Degradable polymers that are frequently used for tissue

Unmanned Aerial Aircraft Systems for transportation engineering: Current practice and future challenges

Directory of Open Access Journals (Sweden)

Emmanouil N. Barmpounakis

2016-10-01

Full Text Available Acquiring and processing video streams from static cameras has been proposed as one of the most efficient tools for visualizing and gathering traffic information. With the latest advances in technology and visual media, combined with the increased needs in dealing with congestion more effectively and directly, the use of Unmanned Aerial Aircraft Systems (UAS has emerged in the field of traffic engineering. In this paper, we review studies and applications that incorporate UAS in transportation research and practice with the aim to set the grounds from the proper understanding and implementation of UAS related surveillance systems in transportation and traffic engineering. The studies reviewed are categorized in different transportation engineering areas. Additional significant applications from other research fields are also referenced to identify other promising applications. Finally, issues and emerging challenges in both a conceptual and methodological level are revealed and discussed.

Photoreconfigurable polymers for biomedical applications: chemistry and macromolecular engineering.

Science.gov (United States)

Zhu, Congcong; Ninh, Chi; Bettinger, Christopher J

2014-10-13

Stimuli-responsive polymers play an important role in many biomedical technologies. Light responsive polymers are particularly desirable because the parameters of irradiated light and diverse photoactive chemistries produce a large number of combinations between functional materials and associated stimuli. This Review summarizes recent advances in utilizing photoactive chemistries in macromolecules for prospective use in biomedical applications. Special focus is granted to selection criterion when choosing photofunctional groups. Synthetic strategies to incorporate these functionalities into polymers and networks with different topologies are also highlighted herein. Prospective applications of these materials are discussed including programmable matrices for controlled release, dynamic scaffolds for tissue engineering, and functional coatings for medical devices. The article concludes by summarizing the state of the art in photoresponsive polymers for biomedical applications including current challenges and future opportunities.

Application of Plagiarism Screening Software in the Chemical Engineering Curriculum

Science.gov (United States)

Cooper, Matthew E.; Bullard, Lisa G.

2014-01-01

Plagiarism is an area of increasing concern for written ChE assignments, such as laboratory and design reports, due to ease of access to text and other materials via the internet. This study examines the application of plagiarism screening software to four courses in a university chemical engineering curriculum. The effectiveness of plagiarism…

SKB's safety case for a final repository license application

International Nuclear Information System (INIS)

Hedin, Allan; Andersson, Johan

2014-01-01

The safety assessment SR-Site is a main component in SKB's license application, submitted in March 2011, to construct and operate a final repository for spent nuclear fuel at Forsmark in the municipality of Oesthammar, Sweden. Its role in the application is to demonstrate long-term safety for a repository at Forsmark. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. The principal regulatory acceptance criterion, issued by the Swedish Radiation Safety Authority (SSM), requires that the annual risk of harmful effects after closure not exceed 10 -6 for a representative individual in the group exposed to the greatest risk. SSM's regulations also imply that the assessment time for a repository of this type is one million years after closure. The licence applied for is one in a stepwise series of permits, each requiring a safety report. The next step concerns a permit to start excavation of the repository and requires a preliminary safety assessment report (PSAR) covering both operational and post-closure safety. Later steps include permission to commence trial operation, to commence regular operation and to close the final repository. (authors)

Applications of super - high intensity lasers in nuclear engineering

International Nuclear Information System (INIS)

Salomaa, R.; Hakola, A.; Santala, M.

2007-01-01

Laser-plasma interactions arising when a super intense ultrashort laser pulse impinges a solid target creates intense partly collimated and energy resolved photons, high energy electron and protons and neutrons. In addition the plasma plume can generate huge magnetic and electric fields. Also ultra short X-ray pulses are created. We have participated in some of such experiments at Rutherford and Max-Planck Institute and assessed the applications of such kind as laser-driven accelerators. This paper discusses applications in nuclear engineering (neutron sources, isotope separation, fast ignition and transmutation, etc). In particular the potential for extreme time resolution and to partial energy resolution are assessed

GPR applications in Civil Engineering in Spain - state-of-the-art

Science.gov (United States)

Pérez Gracia, Vega; Solla, Mercedes; Santos-Assunçao, Sonia; Lorenzo, Henrique

2014-05-01

GPR was introduced in Spain in 1990, and the first significant work was the PhD thesis of H. Lorenzo in 1994. Due to its versatile applicability, the employ has been increased and actually, GPR is extensively used in detection of pipes, wiring and urban services mainly. During the last years, this method was also widely utilized in the detection of graves from the civil war and in forensic studies, with irregular results. It was also commonly applied in archaeology. Actually exists more than 20 private companies offering geotechnical services by means of GPR. Also, several public institutions as Universities and Research Institutes base part of their research in GPR or in GPR applications. Notwithstanding, no training courses of specific formation on GPR is offered, but in several doctorate programs it is possible to work with GPR. Also, in many schools, GPR is part of the geophysical formation of graduate students. However, no national guidelines and rules exist, and each company defines the investigation protocols. Nevertheless, one of the aims of the Comisión Española de Geodesia y Geofísica (Spanish Committee for Geodesy and Geophysics) is to define guidelines for the GPR studies. Probably, the existence of national guidelines or perhaps European guidelines could be the most effective way to promote the responsible use of GPR in different domains. On the other hand, perhaps recommendations on the use of combined methodologies could be a practical way to persuade in the application of geophysical non-destructive technologies. The CEDEX, Centro de Estudios y Experimentación de Obras Públicas (Center for Studies and Experimentation in Civil Engineering), which is a civil engineering research agency in Spain, offers different test sites to calibrate and evaluate the method. It is an autonomous organization, organically ascribed at present to the Ministry of Fomento, and functionally ascribed to the Ministries of Fomento and Medioambiente of Spain, giving

Geothermal engineering fundamentals and applications

CERN Document Server

Watson, Arnold

2013-01-01

This book explains the engineering required to bring geothermal resources into use. The book covers specifically engineering aspects that are unique to geothermal engineering, such as measurements in wells and their interpretation, transport of near-boiling water through long pipelines, turbines driven by fluids other than steam, and project economics. The explanations are reinforced by drawing comparisons with other energy industries.

Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering.

Science.gov (United States)

Singh, Milind; Berkland, Cory; Detamore, Michael S

2008-12-01

From embryonic development to wound repair, concentration gradients of bioactive signaling molecules guide tissue formation and regeneration. Moreover, gradients in cellular and extracellular architecture as well as in mechanical properties are readily apparent in native tissues. Perhaps tissue engineers can take a cue from nature in attempting to regenerate tissues by incorporating gradients into engineering design strategies. Indeed, gradient-based approaches are an emerging trend in tissue engineering, standing in contrast to traditional approaches of homogeneous delivery of cells and/or growth factors using isotropic scaffolds. Gradients in tissue engineering lie at the intersection of three major paradigms in the field-biomimetic, interfacial, and functional tissue engineering-by combining physical (via biomaterial design) and chemical (with growth/differentiation factors and cell adhesion molecules) signal delivery to achieve a continuous transition in both structure and function. This review consolidates several key methodologies to generate gradients, some of which have never been employed in a tissue engineering application, and discusses strategies for incorporating these methods into tissue engineering and implant design. A key finding of this review was that two-dimensional physicochemical gradient substrates, which serve as excellent high-throughput screening tools for optimizing desired biomaterial properties, can be enhanced in the future by transitioning from two dimensions to three dimensions, which would enable studies of cell-protein-biomaterial interactions in a more native tissue-like environment. In addition, biomimetic tissue regeneration via combined delivery of graded physical and chemical signals appears to be a promising strategy for the regeneration of heterogeneous tissues and tissue interfaces. In the future, in vivo applications will shed more light on the performance of gradient-based mechanical integrity and signal delivery

Activities of the Institute for Computer Applications in Science and Engineering (ICASE)

Science.gov (United States)

1988-01-01

This report summarizes research conducted at the Institute for Computer Applications Science and Engineering in applied mathematics, numerical analysis, and computer science during the period October 2, 1987 through March 31, 1988.

[Research Conducted at the Institute for Computer Applications in Science and Engineering

Science.gov (United States)

1997-01-01

This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, fluid mechanics, and computer science during the period 1 Oct. 1996 - 31 Mar. 1997.

Remote sensing applications for transportation and traffic engineering studies: A review of the literature

Science.gov (United States)

Epps, J. W.

1973-01-01

Current references were surveyed for the application of remote sensing to traffic and transportation studies. The major problems are presented that concern traffic engineers and transportation managers, and the literature references that discuss remote sensing applications are summarized.

Generalized Linear Models with Applications in Engineering and the Sciences

CERN Document Server

Myers, Raymond H; Vining, G Geoffrey; Robinson, Timothy J

2012-01-01

Praise for the First Edition "The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities."-Technometrics Generalized Linear Models: With Applications in Engineering and the Sciences, Second Edition continues to provide a clear introduction to the theoretical foundations and key applications of generalized linear models (GLMs). Ma

Application and Network-Cognizant Proxies - Final Report

Energy Technology Data Exchange (ETDEWEB)

Antonio Ortega; Daniel C. Lee

2003-03-24

OAK B264 Application and Network-Cognizant Proxies - Final Report. Current networks show increasing heterogeneity both in terms of their bandwidths/delays and the applications they are required to support. This is a trend that is likely to intensify in the future, as real-time services, such as video, become more widely available and networking access over wireless links becomes more widespread. For this reason they propose that application-specific proxies, intermediate network nodes that broker the interactions between server and client, will become an increasingly important network element. These proxies will allow adaptation to changes in network characteristics without requiring a direct intervention of either server or client. Moreover, it will be possible to locate these proxies strategically at those points where a mismatch occurs between subdomains (for example, a proxy could be placed so as to act as a bridge between a reliable network domain and an unreliable one). This design philosophy favors scalability in the sense that the basic network infrastructure can remain unchanged while new functionality can be added to proxies, as required by the applications. While proxies can perform numerous generic functions, such as caching or security, they concentrate here on media-specific, and in particular video-specific, tasks. The goal of this project was to demonstrate that application- and network-specific knowledge at a proxy can improve overall performance especially under changing network conditions. They summarize below the work performed to address these issues. Particular effort was spent in studying caching techniques and on video classification to enable DiffServ delivery. other work included analysis of traffic characteristics, optimized media scheduling, coding techniques based on multiple description coding, and use of proxies to reduce computation costs. This work covered much of what was originally proposed but with a necessarily reduced scope.

Decomposition techniques in mathematical programming engineering and science applications

CERN Document Server

Conejo, Antonio J; Minguez, Roberto; Garcia-Bertrand, Raquel

2006-01-01

Optimization plainly dominates the design, planning, operation, and c- trol of engineering systems. This is a book on optimization that considers particular cases of optimization problems, those with a decomposable str- ture that can be advantageously exploited. Those decomposable optimization problems are ubiquitous in engineering and science applications. The book considers problems with both complicating constraints and complicating va- ables, and analyzes linear and nonlinear problems, with and without in- ger variables. The decomposition techniques analyzed include Dantzig-Wolfe, Benders, Lagrangian relaxation, Augmented Lagrangian decomposition, and others. Heuristic techniques are also considered. Additionally, a comprehensive sensitivity analysis for characterizing the solution of optimization problems is carried out. This material is particularly novel and of high practical interest. This book is built based on many clarifying, illustrative, and compu- tional examples, which facilitate the learning p...

Knowledge Engineering Aspects of Affective Bi-Modal Educational Applications

Science.gov (United States)

Alepis, Efthymios; Virvou, Maria; Kabassi, Katerina

This paper analyses the knowledge and software engineering aspects of educational applications that provide affective bi-modal human-computer interaction. For this purpose, a system that provides affective interaction based on evidence from two different modes has been developed. More specifically, the system's inferences about students' emotions are based on user input evidence from the keyboard and the microphone. Evidence from these two modes is combined by a user modelling component that incorporates user stereotypes as well as a multi criteria decision making theory. The mechanism that integrates the inferences from the two modes has been based on the results of two empirical studies that were conducted in the context of knowledge engineering of the system. The evaluation of the developed system showed significant improvements in the recognition of the emotional states of users.

Mobile Timekeeping Application Built on Reverse-Engineered JPL Infrastructure

Science.gov (United States)

Witoff, Robert J.

2013-01-01

Every year, non-exempt employees cumulatively waste over one man-year tracking their time and using the timekeeping Web page to save those times. This app eliminates this waste. The innovation is a native iPhone app. Libraries were built around a reverse- engineered JPL API. It represents a punch-in/punch-out paradigm for timekeeping. It is accessible natively via iPhones, and features ease of access. Any non-exempt employee can natively punch in and out, as well as save and view their JPL timecard. This app is built on custom libraries created by reverse-engineering the standard timekeeping application. Communication is through custom libraries that re-route traffic through BrowserRAS (remote access service). This has value at any center where employees track their time.

Application of integrated computer-aided engineering for design, construction and operation of nuclear power plant: practice and prospects

International Nuclear Information System (INIS)

Min, K.S.; Lee, B.H.

1988-01-01

Computer-aided-engineering (CAE) is an essential tool for modern nuclear power plant engineering. It greatly varies in definition, application, and technology from project to project and company to company. Despite the fast growing technologies and applications of CAE, its complexity and variety have thrown another puzzle to management of a nuclear project. Without due consideration of an integrated CAE system in early planning stage, the overall efficiency of a nuclear project would slow down due to the inefficiency in data flow. In this application are discussed under the Korea Power engineering Company philosophy in CAE approach

Computational modeling for eco engineering: Making the connections between engineering and ecology (Invited)

Science.gov (United States)

Bowles, C.

2013-12-01

Ecological engineering, or eco engineering, is an emerging field in the study of integrating ecology and engineering, concerned with the design, monitoring, and construction of ecosystems. According to Mitsch (1996) 'the design of sustainable ecosystems intends to integrate human society with its natural environment for the benefit of both'. Eco engineering emerged as a new idea in the early 1960s, and the concept has seen refinement since then. As a commonly practiced field of engineering it is relatively novel. Howard Odum (1963) and others first introduced it as 'utilizing natural energy sources as the predominant input to manipulate and control environmental systems'. Mtisch and Jorgensen (1989) were the first to define eco engineering, to provide eco engineering principles and conceptual eco engineering models. Later they refined the definition and increased the number of principles. They suggested that the goals of eco engineering are: a) the restoration of ecosystems that have been substantially disturbed by human activities such as environmental pollution or land disturbance, and b) the development of new sustainable ecosystems that have both human and ecological values. Here a more detailed overview of eco engineering is provided, particularly with regard to how engineers and ecologists are utilizing multi-dimensional computational models to link ecology and engineering, resulting in increasingly successful project implementation. Descriptions are provided pertaining to 1-, 2- and 3-dimensional hydrodynamic models and their use at small- and large-scale applications. A range of conceptual models that have been developed to aid the in the creation of linkages between ecology and engineering are discussed. Finally, several case studies that link ecology and engineering via computational modeling are provided. These studies include localized stream rehabilitation, spawning gravel enhancement on a large river system, and watershed-wide floodplain modeling of

Application of carbon fiber reinforced carbon composite to nuclear engineering

International Nuclear Information System (INIS)

Ishihara, Masahiro

2003-01-01

Carbon fiber reinforced carbon matrix composite (C/C composite) is thought to be one of promising structural materials with high temperature resistivity in the nuclear engineering field. In the high temperature gas-cooled reactors with gas outlet temperature maximum around 1000degC, high performance core internal structures, such as control rod sheath, core restraint mechanism, will be expected to achieve by the C/C composite application. Moreover, in the fusion reactors, plasma facing structures having high temperature with high neutron irradiation and particle collision will be expected to achieve by the C/C composite application. In this paper, current research and development studies of the C/C composite application on both reactors are reviewed and vista of the future on the C/C composite application is mentioned. (author)

Trends in high power laser applications in civil engineering

Science.gov (United States)

Wignarajah, Sivakumaran; Sugimoto, Kenji; Nagai, Kaori

2005-03-01

This paper reviews the research and development efforts made on the use of lasers for material processing in the civil engineering industry. Initial investigations regarding the possibility of using lasers in civil engineering were made in the 1960s and '70s, the target being rock excavation. At that time however, the laser powers available were too small for any practical application utilization. In the 1980's, the technology of laser surface cleaning of historically important structures was developed in Europe. In the early 1990s, techniques of laser surface modification, including glazing and coloring of concrete, roughening of granite stones, carbonization of wood were pursued, mainly in Japan. In the latter part of the decade, techniques of laser decontamination of concrete surfaces in nuclear facilities were developed in many countries, and field tests were caried out in Japan. The rapid advances in development of diode lasers and YAG lasers with high power outputs and efficiencies since the late 1990's have led to a revival of worldwide interest in the use of lasers for material processing in civil engineering. The authors believe that, in the next 10 years or so, the advent of compact high power lasers is likely to lead to increased use of lasers of material processing in the field of civil engineering.

Advancing metabolic engineering through systems biology of industrial microorganisms.

Science.gov (United States)

Dai, Zongjie; Nielsen, Jens

2015-12-01

Development of sustainable processes to produce bio-based compounds is necessary due to the severe environmental problems caused by the use of fossil resources. Metabolic engineering can facilitate the development of highly efficient cell factories to produce these compounds from renewable resources. The objective of systems biology is to gain a comprehensive and quantitative understanding of living cells and can hereby enhance our ability to characterize and predict cellular behavior. Systems biology of industrial microorganisms is therefore valuable for metabolic engineering. Here we review the application of systems biology tools for the identification of metabolic engineering targets which may lead to reduced development time for efficient cell factories. Finally, we present some perspectives of systems biology for advancing metabolic engineering further. Copyright © 2015 Elsevier Ltd. All rights reserved.

Medical applications of membranes: Drug delivery, artificial organs and tissue engineering

NARCIS (Netherlands)

Stamatialis, Dimitrios; Papenburg, B.J.; Girones nogue, Miriam; Saiful, S.; Bettahalli Narasimha, M.S.; Schmitmeier, Stephanie; Wessling, Matthias

2008-01-01

This paper covers the main medical applications of artificial membranes. Specific attention is given to drug delivery systems, artificial organs and tissue engineering which seem to dominate the interest of the membrane community this period. In all cases, the materials, methods and the current

Magnetic Resonance Imaging and Velocity Mapping in Chemical Engineering Applications.

Science.gov (United States)

Gladden, Lynn F; Sederman, Andrew J

2017-06-07

This review aims to illustrate the diversity of measurements that can be made using magnetic resonance techniques, which have the potential to provide insights into chemical engineering systems that cannot readily be achieved using any other method. Perhaps the most notable advantage in using magnetic resonance methods is that both chemistry and transport can be followed in three dimensions, in optically opaque systems, and without the need for tracers to be introduced into the system. Here we focus on hydrodynamics and, in particular, applications to rheology, pipe flow, and fixed-bed and gas-solid fluidized bed reactors. With increasing development of industrially relevant sample environments and undersampling data acquisition strategies that can reduce acquisition times to chemical engineering research.

Computational engineering

CERN Document Server

2014-01-01

The book presents state-of-the-art works in computational engineering. Focus is on mathematical modeling, numerical simulation, experimental validation and visualization in engineering sciences. In particular, the following topics are presented: constitutive models and their implementation into finite element codes, numerical models in nonlinear elasto-dynamics including seismic excitations, multiphase models in structural engineering and multiscale models of materials systems, sensitivity and reliability analysis of engineering structures, the application of scientific computing in urban water management and hydraulic engineering, and the application of genetic algorithms for the registration of laser scanner point clouds.

Application of chitosan scaffolds on vascular endothelial growth factor and fibroblast growth factor 2 expressions in tissue engineering principles

Directory of Open Access Journals (Sweden)

Ariyati Retno Pratiwi

2015-12-01

Full Text Available Background: Tissue engineering has given satisfactory results as biological tissue substitutes to restore, replace, or regenerate tissues that have a defect. Chitosan is an organic biomaterial often used in the biomedical field. Chitosan has biocompatible, antifungal, and antibacterial properties. Chitosan is osteoconductive, suitable for bone regeneration applications. Bone defect healing begins with inflammatory phase as a response to the presence of vascular injury, so new vascularization is required. Vascular endothelial growth factor (VEGF and basic fibroblast growth factor-2 (FGF2 are indicators of the beginning of bone regeneration process, playing an important role in angiogenesis. Purpose: This research was aimed to determine the effects of chitosan scaffold application on the expressions of VEGF and FGF2 in tissue engineering principles. Method: Chitosan was dissolved in CH3COOH and NaOH to form a gel. Chitosan gel was then printed in mould to freeze dry for 24 hours. Those rats with defected bones were divided into two groups. Group 1 was the control group which defected bones were not administrated with chitosan scaffolds. Group 2 was the treatment group which defected bones were administrated with chitosan scaffolds. Those rats were sacrificed on day 14. Tissue preparations were made, and then immunohistochemical staining was conducted. Finally, a statistical analysis was conducted using Kruskal Wallis test. Result: There was no significant difference in the expressions of VEGF and FGF2 between the control group and the treatment group (p>0.05. Conclusion: Chitosan scaffolds do not affect the expressions of VEGF and FGF2 during bone regeneration process on day 14 in tissue engineering principles

Engineering evaluation of selective ion-exchange radioactive waste processing at Susquehanna Nuclear Power Plant: Final report

International Nuclear Information System (INIS)

Vance, J.N.

1989-01-01

This final report describes the work performed of an engineering feasibility evaluation of the use and benefits of a selective ion exchange treatment process in the Susquehanna radwaste system. The evaluation addressed operability and processing capability concerns, radiological impacts of operating in the radwaste discharge mode, required hardware modifications to the radwaste and plant make-up systems, impacts on plant water quality limits and impacts on higher waste classifications. An economic analysis is also reported showing the economic benefit of the use of selective ion exchange. 1 ref., 4 figs., 13 tabs

First-year Engineering Education with the Creative Electrical Engineering Laboratory

Science.gov (United States)

Tsukamoto, Takehiko; Sugito, Tetsumasa; Ozeki, Osamu; Ushiroda, Sumio

The Department of Electrical and Electronic Engineering in Toyota National College of Technology has put great emphasis on fundamental subjects. We introduced the creative electrical engineering laboratory into the first-year engineering education since 1998. The laboratory concentrates on the practice exercise. The final questionnaire of students showed that our first-year education is very effective to promote students motivation and their scholastic ability in engineering.

Recent developments in turbomachinery component materials and manufacturing challenges for aero engine applications

Science.gov (United States)

Srinivas, G.; Raghunandana, K.; Satish Shenoy, B.

2018-02-01

In the recent years the development of turbomachinery materials performance enhancement plays a vital role especially in aircraft air breathing engines like turbojet engine, turboprop engine, turboshaft engine and turbofan engines. Especially the transonic flow engines required highly sophisticated materials where it can sustain the entire thrust which can create by the engine. The main objective of this paper is to give an overview of the present cost-effective and technological capabilities process for turbomachinery component materials. Especially the main focus is given to study the Electro physical, Photonic additive removal process and Electro chemical process for turbomachinery parts manufacture. The aeronautical propulsion based technologies are reviewed thoroughly where in surface reliability, geometrical precession, and material removal and highly strengthened composite material deposition rates usually difficult to cut dedicated steels, Titanium and Nickel based alloys. In this paper the past aeronautical and propulsion mechanical based manufacturing technologies, current sophisticated technologies and also future challenging material processing techniques are covered. The paper also focuses on the brief description of turbomachinery components of shaping process and coating in aeromechanical applications.

Fall meeting 2004: information conference on engines. Final and interim reports of the research centres; Herbsttagung 2004: Informationstagung Motoren. Abschluss- und Zwischenberichte der Forschungsstellen

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

The Proceedings (volume R526, 2004) of the Information Conference on Engines which has been held on the 23rd September 2004 in Pforzheim/Germany, contains ten final and interim reports. The subjects of the contributions presented were as follow: particulate filter with NOx storage coating; cause study on damage-relevant knocking combustion; spray wall interaction; binaural transfer path analysis synthesis; acoustical optimized sealing-systems on engine acoustics; working process caused gas exchange noise; knowledge based diesel engine optimization; frontal press fit assemblies; case hardening and autofrettage; oil condition sensor (orig.)

Analogical Reasoning in the Engineering Design Process and Technology Education Applications

Science.gov (United States)

Daugherty, Jenny; Mentzer, Nathan

2008-01-01

This synthesis paper discusses the research exploring analogical reasoning, the role of analogies in the engineering design process, and educational applications for analogical reasoning. Researchers have discovered that analogical reasoning is often a fundamental cognitive tool in design problem solving. Regarding the possible role of analogical…

Nastran's Application in Agricultural Engineering

Science.gov (United States)

Vanwicklen, G. L.

1985-01-01

Finite element analysis has been recognized as a valuable solution method by agricultural engineers. NASTRAN has been obtained by the Agricultural Engineering Department at the University of Georgia. The NASTRAN Thermal Analyzer has been used in the teaching program for an undergraduate course in heat transfer and will be used for a new graduate course in finite element analysis. The NASTRAN Thermal Analyzer has also been applied to several research problems in the Agricultural Engineering Department.

Overview of free-piston Stirling engine technology for space power application

International Nuclear Information System (INIS)

Slaby, J.G.

1987-01-01

An overview is presented of the National Aeronautics and Space Administration (NASA) Lewis Research Center (LeRC) free-piston Stirling engine activities directed toward space-power application. Free-piston Stirling technology is applicable for both solar and nuclear powered systems. As such, the NASA Lewis Research Center serves as the project office to manage the newly initiated SP-100 Advanced Technology program. This program provides the technology push for providing significant component and subsystem options for increased efficiency, reliability and survivability, and power output growth at reduced specific mass. One of the major elements of the program is the development of advanced power conversion of which the Stirling cycle is a viable candidate. Under this program the status of the 25 kWe opposed-piston Space Power Demonstrator Engine (SPDE) is presented. Included in the SPDE discussion are initial differences between predicted and experimental power outputs and power output influenced by variations in regenerators

Soft computing techniques in engineering applications

CERN Document Server

Zhong, Baojiang

2014-01-01

The Soft Computing techniques, which are based on the information processing of biological systems are now massively used in the area of pattern recognition, making prediction & planning, as well as acting on the environment. Ideally speaking, soft computing is not a subject of homogeneous concepts and techniques; rather, it is an amalgamation of distinct methods that confirms to its guiding principle. At present, the main aim of soft computing is to exploit the tolerance for imprecision and uncertainty to achieve tractability, robustness and low solutions cost. The principal constituents of soft computing techniques are probabilistic reasoning, fuzzy logic, neuro-computing, genetic algorithms, belief networks, chaotic systems, as well as learning theory. This book covers contributions from various authors to demonstrate the use of soft computing techniques in various applications of engineering.  

Fuzzy commutative algebra and its application in mechanical engineering

International Nuclear Information System (INIS)

Han, J.; Song, H.

1996-01-01

Based on literature data, this paper discusses the whole mathematical structure about point-fuzzy number set F(R). By introducing some new operations about addition, subtraction, multiplication, division and scalar multiplication, we prove that F(R) can form fuzzy linear space, fuzzy commutative ring, fuzzy commutative algebra in order. Furthermore, we get that A is fuzzy commutative algebra for any fuzzy subset. At last, we give an application of point-fuzzy number to mechanical engineering

Thermodynamic model to study a solar collector for its application to Stirling engines

International Nuclear Information System (INIS)

Abdollahpour, Amir; Ahmadi, Mohammad H.; Mohammadi, Amir H.

2014-01-01

Highlights: • A thermodynamic model is presented to study a solar collector for its application to Stirling engines. • The parabolic collector is analyzed based on optical and thermal. • Effects of changing some conditions and parameters are studied. - Abstract: Energy production through clean and green sources has been paid attention over the last decades owing to high energy consumption and environmental emission. Solar energy is one of the most useful energy sources. Due to high investment cost of centralized generation of electricity and considerable loss in the network, it is necessary to look forward to decentralized electricity generation technologies. Stirling engines have high efficiency and are able to be coupled with solar energy which cannot be applied in internal combustion engines. Solar Stirling engines can be commercialized and used to generate decentralized electricity in small to medium levels. One of the most important steps to set up an efficient solar Stirling engine is choosing and designing the collector. In this study, a solar parabolic collector with 3500 W of power for its application to Stirling engines was designed and analyzed (It is the thermal inlet power for a Stirling engine). We studied the parabolic collector based on optical and thermal analysis. In this case, solar energy is focused by a concentrating mirror and transferred to a pipe containing fluid. MATLAB software was used for obtaining the parameters of the collector, with respect to the geographic, temporal, and environmental conditions, fluid inlet temperature and some other considerations. After obtaining the results of the design, we studied the effects of changing some conditions and parameters such as annular space pressure, type of the gas, wind velocity, environment temperature and absorber pipe coating

A study on the 0D phenomenological model for diesel engine simulation: Application to combustion of Neem methyl esther biodiesel

International Nuclear Information System (INIS)

Ngayihi Abbe, Claude Valery; Nzengwa, Robert; Danwe, Raidandi; Ayissi, Zacharie Merlin; Obonou, Marcel

2015-01-01

Highlights: • We elaborate a 0D model for prediction of diesel engine operating parameters. • We implement the model for Neem methyl ester biodiesel combustion. • We show methyl butanoate and butyrate can be used as surrogates for biodiesel. • The model predicts fuel spray, in cylinder gaseous state and NOx emissions. • We show the model can be effective both in accuracy and computational speed. - Abstract: The design and monitoring of modern diesel engines running on alternative fuels require reliable models that can validly substitute experimental tests and predict their operating characteristics under different load conditions. Although there exists a multitude of models for diesel engines, 0D phenomenological models present the advantages of giving fast and accurate computed results. These models are useful for predicting fuel spray characteristics and instantaneous gas state. However, there are few reported studies on the application of 0D phenomenological models on biodiesel fuel combustion in diesel engines. This work reports the elaboration, validation and application on Neem methyl ester biodiesel (NMEB) combustion of a 0D phenomenological model for diesel engine simulation. The model addresses some specific aspects of diesel engine modeling found in previous studies such as the compromise between computers cost, accurateness and model simplicity, the reduction of the number of empirical fitting constant, the prediction of combustion kinetics with reduction of the need of experimental curve fitting, the ability to simultaneously predict under various loads engine thermodynamic and spray parameters as well as emission characteristics and finally the ability to simulate diesel engine parameters when fueled by alternative fuels. The proposed model predicts fuel spray behavior, in cylinder combustion and nitric oxides (NOx) emissions. The model is implemented through a Matlab code. The model is mainly based on Razlejtsev’s spray evaporation model

Business | College of Engineering & Applied Science

Science.gov (United States)

& Environmental Engineering TA Online Application Civil & Environmental Engineering Research in Computer Science - FAQ's Computer Science TA Online Application Ph.D. Program in Computer Science Electrical Engineering Electrical Engineering TA Online Application Electrical Engineering Research

78 FR 5710 - Airworthiness Directives; Engine Alliance Turbofan Engines

Science.gov (United States)

2013-01-28

... Airworthiness Directives; Engine Alliance Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT... all Engine Alliance GP7270 and GP7277 turbofan engines. This AD requires initial and repetitive...) Applicability This AD applies to all Engine Alliance GP7270 and GP7277 turbofan engines with a high-pressure...

Bio-based materials with novel characteristics for tissue engineering applications - A review.

Science.gov (United States)

Bedian, Luis; Villalba-Rodríguez, Angel M; Hernández-Vargas, Gustavo; Parra-Saldivar, Roberto; Iqbal, Hafiz M N

2017-05-01

Recently, a wider spectrum of bio-based materials and materials-based novel constructs and systems has been engineered with high interests. The key objective is to help for an enhanced/better quality of life in a secure way by avoiding/limiting various adverse effects of some in practice traditional therapies. In this context, different methodological approaches including in vitro, in vivo, and ex vivo techniques have been exploited, so far. Among them, bio-based therapeutic constructs are of supreme interests for an enhanced and efficient delivery in the current biomedical sector of the modern world. The development of new types of novel, effective and highly reliable materials-based novel constructs for multipurpose applications is essential and a core demand to tackle many human health related diseases. Bio-based materials possess several complementary functionalities, e.g. unique chemical structure, bioactivity, non-toxicity, biocompatibility, biodegradability, recyclability, etc. that position them well in the modern world's materials sector. In this context, the utilization of biomaterials provides extensive opportunities for experimentation in the field of interdisciplinary and multidisciplinary scientific research. With an aim to address the global dependence on petroleum-based polymers, researchers have been redirecting their interests to the engineering of biological materials for targeted applications in different industries including cosmetics, pharmaceuticals, and other biotechnological or biomedical applications. Herein, we reviewed biotechnological advancements at large and tissue engineering from a biomaterials perspective in particular and envision directions of future developments. Copyright © 2017 Elsevier B.V. All rights reserved.

Engineering of systems for application of scientific computing in industry

OpenAIRE

Loeve, W.; Loeve,　W.

1992-01-01

Mathematics software is of growing importance for computer simulation in industrial computer aided engineering. To be applicable in industry the mathematics software and supporting software must be structured in such a way that functions and performance can be maintained easily. In the present paper a method is described for development of mathematics software in such a way that this requirement can be met.

The application of microfluidic-based technologies in the cycle of metabolic engineering

Directory of Open Access Journals (Sweden)

Xiaoyan Ma

2016-09-01

Full Text Available The process of metabolic engineering consists of multiple cycles of design, build, test and learn, which is typically laborious and time-consuming. To increase the efficiency and the rate of success of strain engineering, novel instrumentation must be applied. Microfluidics, the control of liquid flow in microstructures, has enabled flexible, accurate, automatic, and high-throughput manipulation of cells in liquid at picoliter to nanoliter scale. These attributes hold great promise in advancing metabolic engineering in terms of the phases of design, build, test and learn. To promote the application of microfluidic-based technologies in strain improvement, this review addressed the potentials of microfluidics and the related approaches in DNA assembly, transformation, strain screening, genotyping and phenotyping, and highlighted their adaptations for single-cell analysis. As a result, this facilitates in-depth understanding of the metabolic network, which in turn promote efficient optimization in the following cycles of strain engineering. Taken together, microfluidic-based technologies enable on-chip workflow, and could greatly accelerate the turnaround of metabolic engineering.

The application of computer image analysis in life sciences and environmental engineering

Science.gov (United States)

Mazur, R.; Lewicki, A.; Przybył, K.; Zaborowicz, M.; Koszela, K.; Boniecki, P.; Mueller, W.; Raba, B.

2014-04-01

The main aim of the article was to present research on the application of computer image analysis in Life Science and Environmental Engineering. The authors used different methods of computer image analysis in developing of an innovative biotest in modern biomonitoring of water quality. Created tools were based on live organisms such as bioindicators Lemna minor L. and Hydra vulgaris Pallas as well as computer image analysis method in the assessment of negatives reactions during the exposition of the organisms to selected water toxicants. All of these methods belong to acute toxicity tests and are particularly essential in ecotoxicological assessment of water pollutants. Developed bioassays can be used not only in scientific research but are also applicable in environmental engineering and agriculture in the study of adverse effects on water quality of various compounds used in agriculture and industry.

Technical support document for land application of sewage sludge. Volume 1. Final report

International Nuclear Information System (INIS)

Jones, A.; Beyer, L.; Rookwood, M.; Pacenka, J.; Bergin, J.

1992-11-01

The document provides the technical background and justification for the U.S. Environmental Protection Agency's (EPA) final regulation (40 CFR Part 503) covering the land application of sewage sludge. The document summarizes current practices in land application and presents data supporting the risk assessment methodology used to derive human health and environmental risk-based limits for contaminants in land applied sewage sludge. The management practices associated with land application are outlined and the different pathways by which contaminants reach highly-exposed individuals (HEIs) through land application are discussed

Applications of Systems Engineering to the Research, Design, and Development of Wind Energy Systems

Energy Technology Data Exchange (ETDEWEB)

Dykes, K.; Meadows, R.; Felker, F.; Graf, P.; Hand, M.; Lunacek, M.; Michalakes, J.; Moriarty, P.; Musial, W.; Veers, P.

2011-12-01

development. To address these challenges, NREL has embarked on an initiative to evaluate how methods of systems engineering can be applied to the research, design and development of wind energy systems. Systems engineering is a field within engineering with a long history of research and application to complex technical systems in domains such as aerospace, automotive, and naval architecture. As such, the field holds potential for addressing critical issues that face the wind industry today. This paper represents a first step for understanding this potential through a review of systems engineering methods as applied to related technical systems. It illustrates how this might inform a Wind Energy Systems Engineering (WESE) approach to the research, design, and development needs for the future of the industry. Section 1 provides a brief overview of systems engineering and wind as a complex system. Section 2 describes these system engineering methods in detail. Section 3 provides an overview of different types of design tools for wind energy with emphasis on NREL tools. Finally, Section 4 provides an overview of the role and importance of software architecture and computing to the use of systems engineering methods and the future development of any WESE programs. Section 5 provides a roadmap of potential research integrating systems engineering research methodologies and wind energy design tools for a WESE framework.

Application of software engineering to development of reactor safety codes

International Nuclear Information System (INIS)

Wilburn, N.P.; Niccoli, L.G.

1981-01-01

Software Engineering, which is a systematic methodology by which a large scale software development project is partitioned into manageable pieces, has been applied to the development of LMFBR safety codes. The techniques have been applied extensively in the business and aerospace communities and have provided an answer to the drastically increasing cost of developing and maintaining software. The five phases of software engineering (Survey, Analysis, Design, Implementation, and Testing) were applied in turn to development of these codes, along with Walkthroughs (peer review) at each stage. The application of these techniques has resulted in SUPERIOR SOFTWARE which is well documented, thoroughly tested, easy to modify, easier to use and maintain. The development projects have resulted in lower overall cost. (orig.) [de

Functionalized hybrid nanofibers to mimic native ECM for tissue engineering applications

International Nuclear Information System (INIS)

Karuppuswamy, Priyadharsini; Venugopal, Jayarama Reddy; Navaneethan, Balchandar; Laiva, Ashang Luwang; Sridhar, Sreepathy; Ramakrishna, Seeram

2014-01-01

Highlights: • Functionalized hybrid polymer mats fabricated for tissue engineering. • Hybrid polymer mats showed high surface area, high porosity and good wettability. • Incorporation of natural polymers modified the properties of nanofiber mats more biologically favorable for biomedical applications. - Abstract: Nanotechnology being one of the most promising technologies today shows an extremely huge potential in the field of tissue engineering to mimic the porous topography of natural extracellular matrix (ECM). Natural polymers are incorporated into the synthetic polymers to fabricate functionalized hybrid nanofibrous scaffolds, which improve cell and tissue compatibility. The present study identified the biopolymers – aloe vera, silk fibroin and curcumin incorporated into polycaprolactone (PCL) as suitable substrates for tissue engineering. Different combinations of PCL with natural polymers – PCL/aloe vera, PCL/silk fibroin, PCL/aloe vera/silk fibroin, PCL/aloe vera/silk fibroin/curcumin were electrospun into nanofibrous scaffolds. The fabricated two dimensional nanofibrous scaffolds showed high surface area, appropriate mechanical properties, hydrophilicity and porosity, required for the regeneration of diseased tissues. The nanofibrous scaffolds were characterized by Scanning electron microscope (SEM), porometry, Instron tensile tester, VCA optima contact angle measurement and FTIR to analyze the fiber diameter and morphology, porosity and pore size distribution, mechanical strength, wettability, chemical bonds and functional groups, respectively. The average fiber diameter of obtained fibers ranged from 250 nm to 350 nm and the tensile strength of PCL scaffolds at 4.49 MPa increased upto 8.3 MPa for PCL/silk fibroin scaffolds. Hydrophobicity of PCL decreased with the incorporation of natural polymers, especially for PCL/aloe vera scaffolds. The properties of as-spun nanofiber scaffolds showed their potential as promising scaffold materials in

Functionalized hybrid nanofibers to mimic native ECM for tissue engineering applications

Energy Technology Data Exchange (ETDEWEB)

Karuppuswamy, Priyadharsini [Center for Nanofibers and Nanotechnology, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore (Singapore); Department Physics and Nanotechnology, SRM University, Kattankulathur, Chennai (India); Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Venugopal, Jayarama Reddy, E-mail: nnijrv@nus.edu.sg [Center for Nanofibers and Nanotechnology, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore (Singapore); Navaneethan, Balchandar [Center for Nanofibers and Nanotechnology, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore (Singapore); Department Physics and Nanotechnology, SRM University, Kattankulathur, Chennai (India); Laiva, Ashang Luwang; Sridhar, Sreepathy; Ramakrishna, Seeram [Center for Nanofibers and Nanotechnology, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore (Singapore)

2014-12-15

Highlights: • Functionalized hybrid polymer mats fabricated for tissue engineering. • Hybrid polymer mats showed high surface area, high porosity and good wettability. • Incorporation of natural polymers modified the properties of nanofiber mats more biologically favorable for biomedical applications. - Abstract: Nanotechnology being one of the most promising technologies today shows an extremely huge potential in the field of tissue engineering to mimic the porous topography of natural extracellular matrix (ECM). Natural polymers are incorporated into the synthetic polymers to fabricate functionalized hybrid nanofibrous scaffolds, which improve cell and tissue compatibility. The present study identified the biopolymers – aloe vera, silk fibroin and curcumin incorporated into polycaprolactone (PCL) as suitable substrates for tissue engineering. Different combinations of PCL with natural polymers – PCL/aloe vera, PCL/silk fibroin, PCL/aloe vera/silk fibroin, PCL/aloe vera/silk fibroin/curcumin were electrospun into nanofibrous scaffolds. The fabricated two dimensional nanofibrous scaffolds showed high surface area, appropriate mechanical properties, hydrophilicity and porosity, required for the regeneration of diseased tissues. The nanofibrous scaffolds were characterized by Scanning electron microscope (SEM), porometry, Instron tensile tester, VCA optima contact angle measurement and FTIR to analyze the fiber diameter and morphology, porosity and pore size distribution, mechanical strength, wettability, chemical bonds and functional groups, respectively. The average fiber diameter of obtained fibers ranged from 250 nm to 350 nm and the tensile strength of PCL scaffolds at 4.49 MPa increased upto 8.3 MPa for PCL/silk fibroin scaffolds. Hydrophobicity of PCL decreased with the incorporation of natural polymers, especially for PCL/aloe vera scaffolds. The properties of as-spun nanofiber scaffolds showed their potential as promising scaffold materials in

Electrospun silk-elastin-like fibre mats for tissue engineering applications

International Nuclear Information System (INIS)

Machado, Raul; Da Costa, André; Padrão, Jorge; Gomes, Andreia; Casal, Margarida; Sencadas, Vitor; Costa, Carlos M; Lanceros-Méndez, Senentxu; Garcia-Arévalo, Carmen; Rodríguez-Cabello, José Carlos

2013-01-01

Protein-based polymers are present in a wide variety of organisms fulfilling structural and mechanical roles. Advances in protein engineering and recombinant DNA technology allow the design and production of recombinant protein-based polymers (rPBPs) with an absolute control of its composition. Although the application of recombinant proteins as biomaterials is still an emerging technology, the possibilities are limitless and far superior to natural or synthetic materials, as the complexity of the structural design can be fully customized. In this work, we report the electrospinning of two new genetically engineered silk-elastin-like proteins (SELPs) consisting of alternate silk- and elastin-like blocks. Electrospinning was performed with formic acid and aqueous solutions at different concentrations without addition of further agents. The size and morphology of the electrospun structures was characterized by scanning electron microscopy showing its dependence on the concentration and solvent used. Treatment with methanol-saturated air was employed to stabilize the structure and promote water insolubility through a time-dependent conversion of random coils into β-sheets (FTIR). The resultant methanol-treated electrospun mats were characterized for swelling degree (570–720%), water vapour transmission rate (1083 g/m 2 /day) and mechanical properties (modulus of elasticity ∼126 MPa). Furthermore, the methanol-treated SELP fibre mats showed no cytotoxicity and were able to support adhesion and proliferation of normal human skin fibroblasts. Adhesion was characterized by a filopodia-mediated mechanism. These results demonstrate that SELP fibre mats can provide promising solutions for the development of novel biomaterials suitable for tissue engineering applications. (paper)

Determination and Application of Comprehensive Specific Frictional Resistance in Heating Engineering

Directory of Open Access Journals (Sweden)

Yanan Tian

2018-01-01

Full Text Available In this study, we analyze the deficiencies of specific frictional resistance in heating engineering. Based on economic specific frictional resistance, we put forward the concept of comprehensive specific frictional resistance, which considers the multiple factors of technology, economy, regulation modes, pipe segment differences, and medium pressure. Then, we establish a mathematical model of a heating network across its lifespan in order to develop a method for determining the comprehensive specific frictional resistance. Relevant conclusions can be drawn from the results. As an application, we have planned the heating engineering for Yangyuan County in China, which demonstrates the feasibility and superiority of the method.

Transglutaminase reactivity with gelatine: perspective applications in tissue engineering.

Science.gov (United States)

Bertoni, F; Barbani, N; Giusti, P; Ciardelli, G

2006-05-01

Gelatine was crosslinked by means of an enzymatic treatment using tissue transglutaminase (tTGase) (Sigma) and microbial transglutaminase (mTGase) (Ajinomoto) which catalyses the formation of isopeptide bonds between the gamma-carbonyl group of a glutamine residue and the epsilon-amino group of a lysine residue. The reaction is an interesting alternative to the traditional glutaraldehyde crosslinking, which has several drawbacks (e.g., in medical application) due to the toxicity of the chemical reagent. To further investigate the possibility to utilize the modified protein for tissue engineering application, TGase crosslinked gelatine was incorporated in a gellan matrix, a polysaccharide, to enhance the stability in aqueous media. Films obtained by casting were characterized by thermal analysis, chemical imaging, swelling behaviour and cell adhesion.

To solve the specific emissions of locomotive diesel engines. Final report

International Nuclear Information System (INIS)

Korhonen, R.; Maeaettaenen, M.

1999-01-01

Ministry of Transport has made a goal to create an uniform system to make it possible to compare emissions of different transport forms. Kymenlaakso Polytechnic was supported by the Mobile Research Programme to measure the specific emissions of locomotive diesel engines. VR Osakeyhtioe has also supported economically the research work. During the research specific emissions of three diesel engines used in locomotives and calculated according to ISO 8178 standard were measured. In all, emissions of 14 engines were measured. For 12 engines measurements were made after the engine shop repair and for two engines before the repairing. Gaseous emissions: nitric oxide, carbon monoxide, carbon dioxide and total hydrocarbons contents were measured. Based on measured emissions and sulphur contents of the oil the weighted emissions were calculated in units g/kWh and g/kg fuel . Particular emissions were measured with dilution method and specific emissions were calculated in same units as for gaseous emissions

Tissue engineered vascular grafts: Origins, development, and current strategies for clinical application.

Science.gov (United States)

Benrashid, Ehsan; McCoy, Christopher C; Youngwirth, Linda M; Kim, Jina; Manson, Roberto J; Otto, James C; Lawson, Jeffrey H

2016-04-15

Since the development of a dependable and durable synthetic non-autogenous vascular conduit in the mid-twentieth century, the field of vascular surgery has experienced tremendous growth. Concomitant with this growth, development in the field of bioengineering and the development of different tissue engineering techniques have expanded the armamentarium of the surgeon for treating a variety of complex cardiovascular diseases. The recent development of completely tissue engineered vascular conduits that can be implanted for clinical application is a particularly exciting development in this field. With the rapid advances in the field of tissue engineering, the great hope of the surgeon remains that this conduit will function like a true blood vessel with an intact endothelial layer, with the ability to respond to endogenous vasoactive compounds. Eventually, these engineered tissues may have the potential to supplant older organic but not truly biologic technologies, which are used currently. Copyright © 2015 Elsevier Inc. All rights reserved.

Internal Combustion Engine Principles with Vehicle Applications

DEFF Research Database (Denmark)