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Sample records for engerix b-20 mcg

  1. Evaluation of immunogenicity and safety of Genevac B: A new recombinant hepatitis b vaccine in comparison with Engerix B and Shanvac B in healthy adults

    Directory of Open Access Journals (Sweden)

    Vijayakumar V

    2004-01-01

    Full Text Available PURPOSE: Genevac B, a new indigenous recombinant hepatitis B vaccine was evaluated for its immunogenicity and safety in comparison with Engerix B (Smithkline Beecham Biologicals, Belgium and Shanvac B (Shantha Biotechnics, India in healthy adult volunteers. METHODS: While 240 study subjects were included in the Genevac B group, 80 each were the subjects for Engerix B and Shanvac B. A three dose regimen of 0,1,2 months was adopted with 20 gm dosage uniformly in all the three groups. Vaccinees were assessed during prevaccination, followup and post vaccination periods for clinical, haematological, biochemical and immunological parameters for safety and immunogenicity. RESULTS: Successful follow-up in all parameters for four months could be achieved in 92.5% (222/240 for Genevac B study subjects and the same was 85% (68/80 and 80% (64/80 for Engerix B and Shanvac B respectively. While 100% seroconversion was observed in all the three groups, the rate of seroprotectivity was 99.5% by Genevac B, 98.5% by Engerix B and 98.4% for Shanvac B. However the difference was not statistically significant (p>0.05. The GMT values of anti HBs after one month of completion of the vaccination were 735.50, 718.23 and 662.20 mIU/mL respectively. No systemic reaction was either seen or reported by the volunteers during the vaccination process of Genevac B and other two vaccines. Clinical, haematological and biochemical safety parameters remained within normal limits throughout the study period. CONCLUSION: The study confirms that Genevac B, the new recombinant Hepatitis B vaccine has the acceptable international standards of safety and immunogenicity.

  2. An overview of four studies of a continuous oral contraceptive (levonorgestrel 90 mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual syndrome

    DEFF Research Database (Denmark)

    Freeman, Ellen W; Halbreich, Uriel; Grubb, Gary S

    2012-01-01

    This article presents an overview of four studies that evaluated a continuous oral contraceptive (OC) containing levonorgestrel (90 mcg) and ethinyl estradiol (20 mcg; LNG/EE) for managing premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS).......This article presents an overview of four studies that evaluated a continuous oral contraceptive (OC) containing levonorgestrel (90 mcg) and ethinyl estradiol (20 mcg; LNG/EE) for managing premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS)....

  3. A randomized, controlled clinical trial to evaluate the immunogenicity of a PreS/S hepatitis B vaccine Sci-B-Vac™, as compared to Engerix B®, among vaccine naïve and vaccine non-responder dialysis patients.

    Science.gov (United States)

    Elhanan, E; Boaz, M; Schwartz, I; Schwartz, D; Chernin, G; Soetendorp, H; Gal Oz, A; Agbaria, A; Weinstein, T

    2018-02-01

    Dialysis patients have a suboptimal response to hepatitis B (HBV) vaccination. This study aimed to compare the immunogenicity of two vaccines: the third-generation Sci-B-Vac™ vs. the second-generation Engerix B ® . The cohort included two groups of dialysis patients: naïve and previously vaccinated non-responders. Primary endpoints were antibody titers ≥10 IU/L at 3 and 7 month post-vaccination. Secondary objectives were seroprotection rates in vaccine-naïve patients and in previously vaccinated non-responders. Eighty-six patients were assigned to vaccine (Sci-B-Vac™ or Engerix B ® ) using computer-generated randomization, stratified by age, gender, diabetes, and previous HBV vaccination. Sci-B-Vac™ was administered in three doses, 10 μg, at 0, 1, and 6 months in naïve patients; or 20 μg in previously vaccinated non-responders. Engerix B ® included four doses, 40 μg at 0, 1, 2, and 6 months. Each group had 43 patients. Seroconversion was 69.8% with Engerix B ® vs. 73.2% with Sci-B-Vac™. Antibody titers at 7 months were higher with Sci-B-Vac™ (266.4 ± 383.9, median 53.4) than with Engerix ® (193.2 ± 328.9, median 19). However, these differences were not significant, perhaps due to a suboptimal sample size. This study suggests comparable immunogenicity for both vaccines. Thus, we cannot reject the null hypothesis that there is no difference in seroconversion by vaccine type. It is noteworthy that naïve patients were vaccinated with a standard dose of Sci-B-Vac™, while Engerix B ® was administered at a double dose. Similarly, although mean antibody titer levels in the Sci-B-Vac™ group were higher than in the Engerix ® group, this difference did not reach significance. Consequently, a future clinical trial should recruit a larger cohort of patients, using a standard double-dose protocol in both groups.

  4. 75 FR 16211 - MCG Capital Corporation; Notice of Application

    Science.gov (United States)

    2010-03-31

    ... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 29191; File No. 812-13694] MCG Capital Corporation; Notice of Application March 25, 2010. AGENCY: Securities and Exchange... exchange on which its shares of common stock may be traded in the future) as of the date of the transaction...

  5. Discussion of Source Reconstruction Models Using 3D MCG Data

    Science.gov (United States)

    Melis, Massimo De; Uchikawa, Yoshinori

    In this study we performed the source reconstruction of magnetocardiographic signals generated by the human heart activity to localize the site of origin of the heart activation. The localizations were performed in a four compartment model of the human volume conductor. The analyses were conducted on normal subjects and on a subject affected by the Wolff-Parkinson-White syndrome. Different models of the source activation were used to evaluate whether a general model of the current source can be applied in the study of the cardiac inverse problem. The data analyses were repeated using normal and vector component data of the MCG. The results show that a distributed source model has the better accuracy in performing the source reconstructions, and that 3D MCG data allow finding smaller differences between the different source models.

  6. Feasibility study on measurement of magnetocardiography (MCG) using fluxgate magnetometer

    Science.gov (United States)

    Sengottuvel, S.; Sharma, Akash; Biswal, Deepak; Khan, Pathan Fayaz; Swain, Pragyna Parimita; Patel, Rajesh; Gireesan, K.

    2018-04-01

    This paper reports the feasibility of measuring weak magnetic fields generated by the electrical activity of the heart using a portable tri-axial fluxgate magnetometer inside a magnetically shielded room. Measurement of Magnetocardiogram (MCG) signals could be successfully demonstrated from a healthy subject using a novel set-up involving a reference fluxgate sensor which simultaneously measures the magnetic fields associated with the ECG waveform measured on the same subject. The timing information provided by R wave peaks of ECG recorded by the reference sensor is utilized to generate trigger locked average of the sensor output of the measurement fluxgate, and extract MCG signals in all the three orthogonal directions (X, Y and Z) on the anterior thorax. It is expected that such portable room temperature measurements using fluxgate sensor could assist in validating the direction of the equivalent current dipole associated with the electrical activity of the human heart. This is somewhat difficult in conventional MCG measurements using SQUID sensors, which usually furnish only the z component of the magnetic field and its spatial derivatives.

  7. Analysis of chaos attractors of MCG-recordings.

    Science.gov (United States)

    Jiang, Shiqin; Yang, Fan; Yi, Panke; Chen, Bo; Luo, Ming; Wang, Lemin

    2006-01-01

    By studying the chaos attractor of cardiac magnetic induction strength B(z) generated by the electrical activity of the heart, we found that its projection in the reconstructed phase space has a similar shape with the map of the total current dipole vector. It is worth noting that the map of the total current dipole vector is computed with MCG recordings measured at 36 locations, whereas the chaos attractor of B(z) is generated by only one cardiac magnetic field recordings on the measured plan. We discuss only two subjects of different ages in this paper.

  8. Investigations of sensitivity and resolution of ECG and MCG in a realistically shaped thorax model

    International Nuclear Information System (INIS)

    Mäntynen, Ville; Konttila, Teijo; Stenroos, Matti

    2014-01-01

    Solving the inverse problem of electrocardiography (ECG) and magnetocardiography (MCG) is often referred to as cardiac source imaging. Spatial properties of ECG and MCG as imaging systems are, however, not well known. In this modelling study, we investigate the sensitivity and point-spread function (PSF) of ECG, MCG, and combined ECG+MCG as a function of source position and orientation, globally around the ventricles: signal topographies are modelled using a realistically-shaped volume conductor model, and the inverse problem is solved using a distributed source model and linear source estimation with minimal use of prior information. The results show that the sensitivity depends not only on the modality but also on the location and orientation of the source and that the sensitivity distribution is clearly reflected in the PSF. MCG can better characterize tangential anterior sources (with respect to the heart surface), while ECG excels with normally-oriented and posterior sources. Compared to either modality used alone, the sensitivity of combined ECG+MCG is less dependent on source orientation per source location, leading to better source estimates. Thus, for maximal sensitivity and optimal source estimation, the electric and magnetic measurements should be combined. (paper)

  9. A neutral hydrogen study of the integral-sign galaxy MCG 12-7-28

    International Nuclear Information System (INIS)

    Bottinelli, L.; Gouguenheim, L.

    1975-01-01

    The 'integral-sign' galaxy MCG 12-7-28 has been studied in the 21-cm line of neutral hydrogen with the Nancay radio telescope. Its integral properties are consistent with the following results: The galaxy has an Sb or Sbc type, it is located at a distance of about 18 Mpc and it is seen edge-on. (orig.) [de

  10. Surface characterization of amorphous and crystallized Fe 80B 20

    Science.gov (United States)

    Huntley, D. R.; Overbury, S. H.; Zehner, D. M.; Budai, J. D.; Brower, W. E.

    1986-11-01

    Recent studies of catalysis by amorphous metals have prompted an interest in their surface properties. We have utilized Auger electron spectroscopy, X-ray photoelectron spectroscopy and low energy alkali ion scattering to study the surface composition, electronic properties and topography of amorphous and crystallized Fe 80B 20 ribbons. The majorresults are that the surface stoichiometry is approximately that of the bulk, unaltered by segregation. Bulk crystallization results in the diffusion of impurities to the surface, but does not change the Fe/B ratio. A small shift in the B1s core level binding energy was observed on crystalline, annealed surfaces relative to amorphous or sputtered surfaces, but no shifts were observed in the iron core level energies. A weak feature due to the B2p levels was observed in the valence band spectra from sputtered surfaces. The surfaces exhibit atomic scale roughness which is not altered by bulk crystallization. Finally, there were no observable differences in the structure, composition or electronic properties between the two sides of the ribbons.

  11. An overview of four studies of a continuous oral contraceptive (levonorgestrel 90 mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual syndrome.

    Science.gov (United States)

    Freeman, Ellen W; Halbreich, Uriel; Grubb, Gary S; Rapkin, Andrea J; Skouby, Sven O; Smith, Lynne; Mirkin, Sebastian; Constantine, Ginger D

    2012-05-01

    This article presents an overview of four studies that evaluated a continuous oral contraceptive (OC) containing levonorgestrel (90 mcg) and ethinyl estradiol (20 mcg; LNG/EE) for managing premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). Three randomized, double-blind, placebo-controlled trials and one open-label, single-treatment substudy examined mean changes from baseline in the Daily Record of Severity of Problems (DRSP) or Penn Daily Symptom Rating (DSR). Improvements from baseline in mean DRSP and DSR scores were observed, but results were not consistent among the studies. Mean percent improvement of premenstrual symptoms ranged from 30% to 59% in controlled trials and 56% to 81% in an open-label substudy. A large placebo effect was also observed in the placebo-controlled studies. Continuous LNG/EE yielded a favorable safety profile. These data, although not consistent, indicate that continuous LNG/EE may reduce the symptoms of PMDD and PMS, providing an option for women who are appropriate candidates for a continuous OC as a contraceptive, the approved indication for this medication. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Rule Extracting based on MCG with its Application in Helicopter Power Train Fault Diagnosis

    International Nuclear Information System (INIS)

    Wang, M; Hu, N Q; Qin, G J

    2011-01-01

    In order to extract decision rules for fault diagnosis from incomplete historical test records for knowledge-based damage assessment of helicopter power train structure. A method that can directly extract the optimal generalized decision rules from incomplete information based on GrC was proposed. Based on semantic analysis of unknown attribute value, the granule was extended to handle incomplete information. Maximum characteristic granule (MCG) was defined based on characteristic relation, and MCG was used to construct the resolution function matrix. The optimal general decision rule was introduced, with the basic equivalent forms of propositional logic, the rules were extracted and reduction from incomplete information table. Combined with a fault diagnosis example of power train, the application approach of the method was present, and the validity of this method in knowledge acquisition was proved.

  13. Rule Extracting based on MCG with its Application in Helicopter Power Train Fault Diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Wang, M; Hu, N Q; Qin, G J, E-mail: hnq@nudt.edu.cn, E-mail: wm198063@yahoo.com.cn [School of Mechatronic Engineering and Automation, National University of Defense Technology, ChangSha, Hunan, 410073 (China)

    2011-07-19

    In order to extract decision rules for fault diagnosis from incomplete historical test records for knowledge-based damage assessment of helicopter power train structure. A method that can directly extract the optimal generalized decision rules from incomplete information based on GrC was proposed. Based on semantic analysis of unknown attribute value, the granule was extended to handle incomplete information. Maximum characteristic granule (MCG) was defined based on characteristic relation, and MCG was used to construct the resolution function matrix. The optimal general decision rule was introduced, with the basic equivalent forms of propositional logic, the rules were extracted and reduction from incomplete information table. Combined with a fault diagnosis example of power train, the application approach of the method was present, and the validity of this method in knowledge acquisition was proved.

  14. Entropy-based automated classification of independent components separated from fMCG

    International Nuclear Information System (INIS)

    Comani, S; Srinivasan, V; Alleva, G; Romani, G L

    2007-01-01

    Fetal magnetocardiography (fMCG) is a noninvasive technique suitable for the prenatal diagnosis of the fetal heart function. Reliable fetal cardiac signals can be reconstructed from multi-channel fMCG recordings by means of independent component analysis (ICA). However, the identification of the separated components is usually accomplished by visual inspection. This paper discusses a novel automated system based on entropy estimators, namely approximate entropy (ApEn) and sample entropy (SampEn), for the classification of independent components (ICs). The system was validated on 40 fMCG datasets of normal fetuses with the gestational age ranging from 22 to 37 weeks. Both ApEn and SampEn were able to measure the stability and predictability of the physiological signals separated with ICA, and the entropy values of the three categories were significantly different at p <0.01. The system performances were compared with those of a method based on the analysis of the time and frequency content of the components. The outcomes of this study showed a superior performance of the entropy-based system, in particular for early gestation, with an overall ICs detection rate of 98.75% and 97.92% for ApEn and SampEn respectively, as against a value of 94.50% obtained with the time-frequency-based system. (note)

  15. Observations of MCG-5-23-16 with Suzaku, XMM-Newton and Nustar

    DEFF Research Database (Denmark)

    Zoghbi, A.; Cackett, E. M.; Reynolds, C.

    2014-01-01

    MCG-5-23-16 is one of the first active galactic nuclei (AGNs) where relativistic reverberation in the iron K line originating in the vicinity of the supermassive black hole was found, based on a short XMM-Newton observation. In this work, we present the results from long X-ray observations using...... Suzaku, XMM-Newton, and NuSTAR designed to map the emission region using X-ray reverberation. A relativistic iron line is detected in the lag spectra on three different timescales, allowing the emission from different regions around the black hole to be separated. Using NuSTAR coverage of energies above...

  16. 11C-MCG: Synthesis, Uptake Selectivity, and Primate PET of a Probe for Glutamate Carboxypeptidase II (NAALADase

    Directory of Open Access Journals (Sweden)

    Martin G. Pomper

    2002-04-01

    Full Text Available Imaging of glutamate carboxypeptidase II (GCP II, also known as N-acetylated α-linked l-amino dipeptidase (NAALADase, may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo. Our goal was to develop a probe for GCP II for use with positron emission tomography (PET. Radiosynthesis of 11C–MeCys–C(O–Glu or 11C-(S-2-[3-((R-1-carboxy-2-methylsulfanyl-ethyl-ureido]-pentanedioic acid (11C-MCG, an asymmetric urea and potent (Ki = 1.9 nM inhibitor of GCP II, was performed by C-11 methylation of the free thiol. Biodistribution of 11C-MCG was assayed in mice, and quantitative PET was performed in a baboon. 11C-MCG was obtained in 16% radiochemical yield at the end of synthesis with specific radioactivities over 167 GBq/mmol (4000 Ci/mmol within 30 min after the end of bombardment. At 30 min postinjection, 11C-MCG showed 33.0 ± 5.1%, 0.4 ± 0.1%, and 1.1 ± 0.2% ID/g in mouse kidney (target tissue, muscle, and blood, respectively. Little radioactivity gained access to the brain. Blockade with unlabeled MCG or 2-(phosphonomethylpentanedioic acid (PMPA, another potent inhibitor of GCP II, provided sevenfold and threefold reductions, respectively, in binding to target tissue. For PET, distribution volumes (DVs were 1.38 then 0.87 pre- and postblocker (PMPA. Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery.

  17. Moessbauer study of corrosion products formed on Fe80B20 and Fe40Ni40 (MoB)20 amorphous alloys in an SO2-polluted atmosphere

    International Nuclear Information System (INIS)

    Davalos, J.; Marco, J.F.; Gracia, M.; Gancedo, J.R.; Greneche, J.M.

    1990-01-01

    ICEMS, XPS, XRD, and AES have been used to study the corrosion layers formed on two metallic glasses, Fe 80 B 20 and Fe 40 Ni 40 (MoB) 20 (2605 and 2826 MB, Allied Company), exposed to an SO 2 -polluted humid atmosphere. The iron-containing corrosion products are the same found for pure iron in the same environment, but different relative concentrations were clearly evidenced by ICEMS results. Elemental sulphur, Ni(OH) 2 , and B(OH) 3 , the latter enriched at the surface, were found by XPS, XRD and AES. (orig.)

  18. An Extended Multi-Zone Model for the MCG-6-30-15 Warm Absorber

    Science.gov (United States)

    Morales, R.; Fabian, A. C.; Reynolds, C. S.

    2000-01-01

    The variable warm absorber seen with ASCA in the X-ray spectrum of MCG 6-30-15 shows complex time behaviour in which the optical depth of O VIII anticorrelates with the flux whereas that of O VII is unchanging. The explanation in terms of a two zone absorber has since been challenged by BeppoSAX observations. These present a more complicated behaviour for the O VII edge. The explanation we offer for both ASCA and BeppoSAX observations requires a very simple photoionization model together with the presence of a third, intermediate, zone and a period of very low luminosity. In practice warm absorbers are likely to be extended, multi-zone regions of which only part causes directly observable absorption edges at any given time depending on the value of the luminosity.

  19. ROLE OF 400 MCG INTRAOPERATIVE SUBLINGUAL MISOPROSTOL FOR REDUCTION OF CAESAREAN BLOOD LOSS

    Directory of Open Access Journals (Sweden)

    Lalmohan Nayak

    2017-02-01

    Full Text Available BACKGROUND Lower segment caesarean section is a common surgical procedure. Postpartum haemorrhage incidence after LSCS is 4%. Misoprostol is a prostaglandin E1 analogue with good uterotonic properties, easy availability, low cost, thermostability, long shelf life, easy administration and few adverse effects at therapeutic dose. It is readily absorbed by oral, sublingual, buccal, vaginal or rectal route. Sublingual route attains quickest concentration. Dose of 400 mcg was chosen in this study to minimise adverse effects with optimal therapeutic benefit. The aim of the study is to determine the efficacy of sublingual misoprostol in reducing caesarean blood loss. MATERIALS AND METHODS It is a prospective experimental study done in VSSIMSAR, Burla. Women undergoing LSCS were randomly assigned to study and control groups of equal strength of 100 each. In all cases, preoperative Hb%, haematocrit, pulse, BP was noted. Study group were given 400 mcg misoprostol at the time of cord clamping. In control group, nothing was given. In all patients, active management of third stage of labour was done by using oxytocin 10 IU (IV along with uterine massage. Blood loss soaked by tetra was calculated using formula, blood loss = wet weight-dry weight/1.05 (1.05 is constant. Amount of blood loss, postoperative Hb%, haematocrit, pulse rate, BP was noted in both groups and compared. BP and pulse were noted after 1 hour and Hb%, haematocrit were noted after 24 hours. RESULTS Study group showed significant decrease in total blood loss (around 117.9 mL as compared to control group. There was significant decrease in the postoperative fall in Hb in the study group as compared to control, the mean difference being 0.631 gm%. Study group also showed decrease in postoperative fall in haematocrit as compared to control, the mean difference being 0.055. CONCLUSION Misoprostol significantly reduced caesarean blood loss and doesn’t affect foetal outcome without significant

  20. The Broadband Spectral Variability of MCG-6-30-15 Observed by NUSTAR and XMM-NEWTON

    DEFF Research Database (Denmark)

    Marinucci, A.; Matt, G.; Miniutti, G.

    2014-01-01

    MCG-6-30-15, at a distance of 37 Mpc (z = 0.008), is the archetypical Seyfert 1 galaxy showing very broad Fe K alpha emission. We present results from a joint NuSTAR and XMM-Newton observational campaign that, for the first time, allows a sensitive, time-resolved spectral analysis from 0.35 keV u...

  1. Performance comparison of independent component analysis algorithms for fetal cardiac signal reconstruction: a study on synthetic fMCG data

    International Nuclear Information System (INIS)

    Mantini, D; II, K E Hild; Alleva, G; Comani, S

    2006-01-01

    Independent component analysis (ICA) algorithms have been successfully used for signal extraction tasks in the field of biomedical signal processing. We studied the performances of six algorithms (FastICA, CubICA, JADE, Infomax, TDSEP and MRMI-SIG) for fetal magnetocardiography (fMCG). Synthetic datasets were used to check the quality of the separated components against the original traces. Real fMCG recordings were simulated with linear combinations of typical fMCG source signals: maternal and fetal cardiac activity, ambient noise, maternal respiration, sensor spikes and thermal noise. Clusters of different dimensions (19, 36 and 55 sensors) were prepared to represent different MCG systems. Two types of signal-to-interference ratios (SIR) were measured. The first involves averaging over all estimated components and the second is based solely on the fetal trace. The computation time to reach a minimum of 20 dB SIR was measured for all six algorithms. No significant dependency on gestational age or cluster dimension was observed. Infomax performed poorly when a sub-Gaussian source was included; TDSEP and MRMI-SIG were sensitive to additive noise, whereas FastICA, CubICA and JADE showed the best performances. Of all six methods considered, FastICA had the best overall performance in terms of both separation quality and computation times

  2. Effective utilization of B20 blend with diethyl ether and ethanol as oxygenated additives

    Directory of Open Access Journals (Sweden)

    Upadrasta-Satya Vara-Prasad

    2011-01-01

    Full Text Available In the recent times' fatty acid methyl ester popularly called as biodiesel has become more prominent alternate fuel for compression ignition engines based on a single fuel concept. Since, use of neat biodiesel on a large scale is raising certain difficulties and is being adopted in a blended form with petro-diesel fuel and B20 blend has become standardized. However, the HC and NOx emissions of B20 are still on the higher side. Present work aims at experimental evaluation of a single cylinder water-cooled diesel engine by adopting various proportions of ethanol and diethyl ether blends in order to improve performance and emission characteristics of B20 blend. Besides employing different amounts of ethanol and diethyl ether, simultaneous influence of injector nozzle hole size and fuel injection pressure are also investigated to arrive at an optimum configuration. Brake specific fuel consumption and hydrocarbon emissions values are lower with B20 and DEE 5 whereas B20 with DEE15 yielded lower NOx emissions. It is observed that addition of oxygenates have improved the combustion process and lower emissions are obtained. The present investigation revealed that blends with oxygenated additives having higher Cetane rating are superior to neat blend.

  3. Performance comparison of six independent components analysis algorithms for fetal signal extraction from real fMCG data

    International Nuclear Information System (INIS)

    Hild, Kenneth E; Alleva, Giovanna; Nagarajan, Srikantan; Comani, Silvia

    2007-01-01

    In this study we compare the performance of six independent components analysis (ICA) algorithms on 16 real fetal magnetocardiographic (fMCG) datasets for the application of extracting the fetal cardiac signal. We also compare the extraction results for real data with the results previously obtained for synthetic data. The six ICA algorithms are FastICA, CubICA, JADE, Infomax, MRMI-SIG and TDSEP. The results obtained using real fMCG data indicate that the FastICA method consistently outperforms the others in regard to separation quality and that the performance of an ICA method that uses temporal information suffers in the presence of noise. These two results confirm the previous results obtained using synthetic fMCG data. There were also two notable differences between the studies based on real and synthetic data. The differences are that all six ICA algorithms are independent of gestational age and sensor dimensionality for synthetic data, but depend on gestational age and sensor dimensionality for real data. It is possible to explain these differences by assuming that the number of point sources needed to completely explain the data is larger than the dimensionality used in the ICA extraction

  4. A SUZAKU OBSERVATION OF MCG -2-58-22: CONSTRAINING THE GEOMETRY OF THE CIRCUMNUCLEAR MATERIAL

    International Nuclear Information System (INIS)

    Rivers, Elizabeth; Markowitz, Alex; Rothschild, Richard

    2011-01-01

    We have analyzed a long-look Suzaku observation of the active galactic nucleus MCG -2-58-22, a type 1.5 Seyfert with very little X-ray absorption in the line of sight and prominent features arising from reflection off circumnuclear material: the Fe line and Compton reflection hump. We place tight constraints on the power-law photon index (Γ = 1.80 ± 0.02), the Compton reflection strength (R = 0.69 ± 0.05), and the Fe K emission line energy centroid and width (E = 6.40 ± 0.02 keV, v FWHM -1 ). We find no significant evidence either for emission from strongly ionized Fe, or for a strong, relativistically broadened Fe line, indicating that perhaps there is no radiatively efficient accretion disk very close in to the central black hole. In addition, we test a new self-consistent physical model from Murphy and Yaqoob, the M YTORUSmodel, consisting of a donut-shaped torus of material surrounding the central illuminating source and producing both the Compton hump and the Fe K line emission. From the application of this model we find that the observed spectrum is consistent with a Compton-thick torus of material (column density N H = 3.6 +1.3 -0.8 x 10 24 cm -2 ) lying outside of the line of sight to the nucleus, leaving it bare of X-ray absorption in excess of the Galactic column. We calculate that this material is sufficient to produce all of the Fe line flux without the need for any flux contribution from additional Compton-thin circumnuclear material.

  5. Effect of EGR on a sationary VCR diesel engine using cottonseed biodiesel (B20 fuel

    Directory of Open Access Journals (Sweden)

    Nitin M. Sakhare

    2016-09-01

    Full Text Available This paper presents a view on comparative study of use of diesel fuel with B20 biodieselblend (Diesel (80 %, by vol. and Cotton seed oil (20 %, by vol. derived from Cotton seeds. As higher NOx emission and higher brake specific fuel consumption are main challenges for effective utilization of biodiesel fuel in a diesel engine, there is alarming need to find out the long term solution to reduce NOx emission for better utilization of biodiesel fuel in a diesel engine. Exhaust gas recirculation (EGR is one of the useful technologies to reduce the NOx emission of a diesel engine. In the present research work test is conducted on 3 KW single cylinder, four stroke, water cooled, variable compression ratio (VCR computerized diesel engine using diesel and B20 cotton seed biodiesel blend to study the effect of exhaust gas recirculation on performance and emissions characteristics of a diesel engine in terms of fuel consumption, thermal efficiency and emissions such as hydrocarbon (HC, carbon monoxide (CO, oxides of nitrogen (NOx and carbon dioxide (CO2 of a diesel engine. The constant engine speed of 1500 rpm was maintained through-out the experiment test. The exhaust gas recirculation was varied as 4 % and 6 % at different loading conditions with diesel and B20 biodiesel. The results show that the significant reduction in oxides of nitrogen (NOx with 4 % and 6 % EGR for B20 whereas marginal increment in CO and HC emissions.

  6. Experimental and numerical assessment of ignition delay period for pure diesel and biodiesel B20

    Science.gov (United States)

    Aldhaidhawi, Mohanad; Brabec, Marek; Lucian, Miron; Chiriac, Radu; Bădescu, Viorel

    2017-10-01

    The ignition delay period for a compression ignition engine fueled alternatively with pure diesel and with biodiesel B20 has been experimentally and numerically investigated. The engine was operated under full load conditions for two speeds, 1400 rpm speed for maximum brake torque and 2400 rpm speed for maximum brake power. Different parameters suggested as important to define the start of combustion have been considered before the acceptance of a certain evaluation technique of ignition delay. Correlations between these parameters were analyzed and concluded about the best method to identify the start of combustion. The experimental results were further compared with the ignition delay predicted by some correlations. The results showed that the determined ignition delays are in good agreement with those of the Arrhenius type expressions for pure diesel fuel, while for biodiesel B20 the correlation results are significantly different than the experimental results.

  7. Positive magnetoresistance in Co40Fe40B20/SiO2/Si heterostructure

    KAUST Repository

    Zhang, Y.

    2016-07-20

    Current-perpendicular-to-plane electronic transport properties and magnetoresistance of amorphous Co40Fe40B20/SiO2/Si heterostructures are investigated systematically. A backward diode-like rectifying behavior was observed due to the formation of a Schottky barrier between Co40Fe40B20 and Si. The junction resistance shows a metal-insulator transition with decreasing temperature in both the forward and reverse ranges. A large positive magnetoresistance (MR) of ∼2300% appears at 200 K. The positive MR can be attributed to the magnetic-field-controlled impact ionization process of carriers. MR shows a temperature-peak-type character under a constant bias current, which is related to the spin-dependent barrier in the Si near the interface. © CopyrightEPLA, 2016.

  8. Positive magnetoresistance in Co40Fe40B20/SiO2/Si heterostructure

    KAUST Repository

    Zhang, Y.; Mi, W. B.; Zhang, Xixiang

    2016-01-01

    Current-perpendicular-to-plane electronic transport properties and magnetoresistance of amorphous Co40Fe40B20/SiO2/Si heterostructures are investigated systematically. A backward diode-like rectifying behavior was observed due to the formation of a Schottky barrier between Co40Fe40B20 and Si. The junction resistance shows a metal-insulator transition with decreasing temperature in both the forward and reverse ranges. A large positive magnetoresistance (MR) of ∼2300% appears at 200 K. The positive MR can be attributed to the magnetic-field-controlled impact ionization process of carriers. MR shows a temperature-peak-type character under a constant bias current, which is related to the spin-dependent barrier in the Si near the interface. © CopyrightEPLA, 2016.

  9. Structural Relaxation in Fe78Nb2B20 Amorphous Alloy Studied by Moessbauer Spectroscopy

    International Nuclear Information System (INIS)

    Kansy, J.; Hanc, A.; Rasek, J.; Haneczok, G.; Pajak, L.; Stoklosa, Z.; Kwapulinski, P.

    2011-01-01

    It was shown that soft magnetic properties of Fe 78 Nb 2 B 20 amorphous alloy can be significantly improved by applying 1-h annealing at temperature 623 K (permeability increases even about 8 times). The Moessbauer Spectroscopy technique indicated that the optimized microstructure (corresponding to the maximum magnetic permeability) is free of iron nanograins and should be attributed to annealing out of free volume and a reduction of internal stresses i.e. to the relaxed amorphous phase. (authors)

  10. Positron lifetime and Moessbauer study of Fe80-xNixB20 metallic glasses

    International Nuclear Information System (INIS)

    Baluch, S.; Miglierini, M.; Groene, R.; Sitek, J.

    1989-01-01

    In order to investigate the short-range order (SRO) of iron-rich Fe 80-x Ni x B 20 (x = 10, 20, 30, 40) metallic glasses positron lifetime and Moessbauer measurements were carried out. Positron lifetimes of samples and Moessbauer hyperfine structure data of neutron-irradiated samples as functions of nickel content are shown and discussed. Results give evidence that high Ni content stabilizes the structure and can be connected with a higher degree of SRO in metallic glasses

  11. Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU per day on biochemical responses and the wellbeing of patients

    Directory of Open Access Journals (Sweden)

    Hu Amanda

    2004-07-01

    Full Text Available Abstract Background For adults, vitamin D intake of 100 mcg (4000 IU/day is physiologic and safe. The adequate intake (AI for older adults is 15 mcg (600 IU/day, but there has been no report focusing on use of this dose. Methods We compared effects of these doses on biochemical responses and sense of wellbeing in a blinded, randomized trial. In Study 1, 64 outpatients (recruited if summer 2001 25(OHD Results In Study 1, basal summer 25-hydroxyvitamin D [25(OHD] averaged 48 ± 9 (SD nmol/L. Supplementation for more than 6 months produced mean 25(OHD levels of 79 ± 30 nmol/L for the 15 mcg/day group, and 112 ± 41 nmol/L for the 100 mcg/day group. Both doses lowered plasma parathyroid hormone with no effect on plasma calcium. Between December and February, wellbeing score improved more for the 100-mcg/day group than for the lower-dosed group (1-tail Mann-Whitney p = 0.036. In Study 2, 25(OHD averaged 39 ± 9 nmol/L, and winter wellbeing scores improved with both doses of vitamin D (two-tail p Conclusion The highest AI for vitamin D brought summertime 25(OHD to >40 nmol/L, lowered PTH, and its use was associated with improved wellbeing. The 100 mcg/day dose produced greater responses. Since it was ethically necessary to provide a meaningful dose of vitamin D to these insufficient patients, we cannot rule out a placebo wellbeing response, particularly for those on the lower dose. This work confirms the safety and efficacy of both 15 and 100 mcg/day vitamin D3 in patients who needed additional vitamin D.

  12. NuSTAR spectral analysis of two bright Seyfert 1 galaxies: MCG +8-11-11 and NGC 6814

    Science.gov (United States)

    Tortosa, A.; Bianchi, S.; Marinucci, A.; Matt, G.; Middei, R.; Piconcelli, E.; Brenneman, L. W.; Cappi, M.; Dadina, M.; De Rosa, A.; Petrucci, P. O.; Ursini, F.; Walton, D. J.

    2018-01-01

    We report on the NuSTAR observations of two bright Seyfert 1 galaxies, namely MCG +8-11-11 (100 ks) and NGC 6814 (150 ks). The main goal of these observations was to investigate the Comptonization mechanisms acting in the innermost regions of an active galactic nucleus (AGN) which are believed to be responsible for the UV/X-ray emission. The spectroscopic analysis of the NuSTAR spectra of these two sources revealed that although they had different properties overall (black hole masses, luminosity and Eddington ratios), they had very similar coronal properties. Both presented a power-law spectrum with a high-energy cut-off at ∼150-200 keV, a relativistically broadened Fe K α line and the associated disc reflection component, plus a narrow iron line likely emitted in Compton thin and distant matter. The intrinsic continuum was well described by Comptonization models that show for MCG +8-11-11 a temperature of the coronal plasma of kTe ∼ 60 keV and an extrapolated optical depth τ = 1.8; for NGC 6814, the coronal temperature was kTe ∼ 45 keV with an extrapolated optical depth of τ = 2.5. We compare and discuss these values to some most common Comptonization models that aim at explaining the energy production and stability of coronae in AGNs.

  13. Magnetic and Moessbauer studies of amorphous Fe72-xYxHo8B20 alloys

    International Nuclear Information System (INIS)

    Krishnan, R.; Dumond, Y.; Ajan, A.; Shringi, S.N.; Prasad, S.

    1996-01-01

    We have carried out magnetic and Moessbauer studies of amorphous Fe 72-x Y x Ho 8 B 20 alloys. The Fe moment decreases with the addition of Y and a magnetic compensation occurs at 4 K for x=16. The temperature and field dependences of the magnetization have been interpreted using the mean field theory and Chudnovsky's model, respectively. These analyses yield some interesting parameters such as the random anisotropy, the exchange interactions J Fe-Fe , J Fe-Ho , etc. The Moessbauer studies show that the average hyperfine field decreases linearly with the addition of Y, in accordance with the decrease in the Fe moment. (orig.)

  14. Magnetic exchange coupling in amorphous Fe80-xDy xB20 alloys

    International Nuclear Information System (INIS)

    Annouar, F.; Lassri, H.; Ayadi, M.; Omri, M.; Lassri, M.; Krishnan, R.

    2005-01-01

    Amorphous Fe 80-x Dy x B 20 alloys have been prepared by melt spinning and their magnetic properties have been studied. The mean field theory has been used to explain the temperature dependence of the magnetization. The exchange interactions between Co-Co and Dy-Co atom pairs have been evaluated. High-field magnetization studies on samples with stoichiometry close to that of a compensated ferrimagnet show a magnetic behavior that is characteristic of a non-collinear magnetic structure of the Dy and Fe sublattices. The region of the canted moments can be described by a phase diagram in the H-T plane

  15. Soot accumulation in diesel particulate filters using ULSD and B20 biodiesel fuel blends

    Energy Technology Data Exchange (ETDEWEB)

    Charbonneau, P.; Wallace, J.S. [Toronto Univ., ON (Canada)

    2009-07-01

    Soot accumulation in a diesel particulate filter was investigated using a newly developed dissection method that loads and dissects diesel particulate filters (DPFs). In particular, this study examined the differences in soot accumulation between ultra-low sulphur diesel (ULSD) and a B20 biodiesel blend. DPFs loaded for exposure times of 1, 2, 5 and 10 hours. Scanning electron microscopy (SEM) was used to analyze the samples of the filter substrate. The differences in particulate size and number distribution between fuels were attributed to performance differences in DPFs. ULSD loaded filters experienced increased loading and a greater pressure drop across the filters. According to SEM images, the soot cake was a relatively shallow feature increasing in density to form discrete coarse agglomerates and cakes. It was concluded that this newly developed methodology has potential for future studies in DPF loading.

  16. Neutron depolarization study of internal stresses in amorphous Fe40Ni40B20

    International Nuclear Information System (INIS)

    de Jong, M.; Sietsma, J.; Rekveldt, M.T.; van den Beukel, A.

    1997-01-01

    The magnetic domain structure of amorphous ferromagnets with nonzero magnetostriction is mainly determined by the internal stress state because of the magneto-elastic coupling. The stress and field dependence of the domain structure contains important information on the internal stresses in the material. The three-dimensional neutron depolarization technique has been used to study the stress- and field-dependence of the bulk domain structures in both as-quenched and annealed ribbons of the metallic glass Fe 40 Ni 40 B 20 . A three-layer domain structure model corresponding to compressive and tensile internal stresses is presented to explain the measured data. The influence of surface roughness on the interpretation of neutron depolarization measurements in amorphous ribbons is discussed. Finally, the internal stress relaxation due to the annealing is explained in terms of the viscous behaviour of the glass. copyright 1997 American Institute of Physics

  17. Temperature dependence of the electrical resistivity of amorphous Co80-xErxB20 alloys

    International Nuclear Information System (INIS)

    Touraghe, O.; Khatami, M.; Menny, A.; Lassri, H.; Nouneh, K.

    2008-01-01

    The temperature dependence of the electrical resistivity of amorphous Co 80-x Er x B 20 alloys with x=0, 3.9, 7.5 and 8.6 prepared by melt spinning in pure argon atmosphere was studied. All amorphous alloys investigated here are found to exhibit a resistivity minimum at low temperature. The electrical resistivity exhibits logarithmic temperature dependence below the temperature of resistivity minimum T min . In addition, the resistivity shows quadratic temperature behavior in the interval T min < T<77 K. At high temperature, the electrical resistivity was discussed by the extended Ziman theory. For the whole series of alloys, the composition dependence of the temperature coefficient of electrical resistivity α shows a change in structural short range occurring in the composition range 8-9 at%

  18. Skyrmions and Novel Spin Textures in FeGe Thin Films and Artificial B20 Heterostructures

    Science.gov (United States)

    Ahmed, Adam Saied

    Skyrmions are magnetic spin textures that have a non-zero topological winding number associated with them. They have attracted much interest recently since they can be as small as 1 nm and could be the next generation of magnetic memory and logic. First, we grow epitaxial films of FeGe by molecular beam epitaxy and characterized the skyrmion properties. This had led us to image skyrmions in real-space with Lorentz transmission electron microscopy for the first time in the United States. Next, from an extensive series of thin and thick films, we have experimentally shown the existence of a magnetic surface state in FeGe and, consequently, any skyrmion material for the first time. Complementary theoretical calculations supported the existence of chiral bobbers--a surface state only predicted in 2015. Next, we fabricated for the first time a new class of skyrmion materials: B20 superlattices. These novel heterostructures of [FeGe/MnGe/CrGe] have now opened the door for tunable skyrmion systems with both Dresselhaus and Rashba Dzyaloshinskii-Moriya interactions. Additionally, we perform resonant soft x-ray scattering to image magnetic spin textures in reciprocal space for FeGe thin films in transmission. We have accomplished the removal of substrate and left an isolated single-crystal FeGe film. Lastly, SrO is grown on graphene as a crystalline, atomically smooth, and pinhole free tunnel barrier for spin injection.

  19. Surface crystallization and magnetic properties of amorphous Fe80B20 alloy

    International Nuclear Information System (INIS)

    Vavassori, P.; Ronconi, F.; Puppin, E.

    1997-01-01

    We have studied the effects of surface crystallization on the magnetic properties of Fe 80 B 20 amorphous alloys. The surface magnetic properties have been studied with magneto-optic Kerr measurements, while those of bulk with a vibrating sample magnetometer. This study reveals that surface crystallization is similar to the bulk process but occurs at a lower temperature. At variance with previous results on other iron-based amorphous alloys the surface crystalline layer does not induce bulk magnetic hardening. Furthermore, both the remanence to saturation ratio and the bulk magnetic anisotropy do not show appreciable variations after the formation of the surface crystalline layer. The Curie temperature of the surface layer is lower with respect to the bulk of the sample. These effects can be explained by a lower boron concentration in the surface region of the as-cast amorphous alloy. Measurements of the chemical composition confirm a reduction of boron concentration in the surface region. copyright 1997 American Institute of Physics

  20. Involvement of the ornithine decarboxylase gene in acid stress response in probiotic Lactobacillus delbrueckii UFV H2b20.

    Science.gov (United States)

    Ferreira, A B; Oliveira, M N V de; Freitas, F S; Paiva, A D; Alfenas-Zerbini, P; Silva, D F da; Queiroz, M V de; Borges, A C; Moraes, C A de

    2015-01-01

    Amino acid decarboxylation is important for the maintenance of intracellular pH under acid stress. This study aims to carry out phylogenetic and expression analysis by real-time PCR of two genes that encode proteins involved in ornithine decarboxylation in Lactobacillus delbrueckii UFV H2b20 exposed to acid stress. Sequencing and phylogeny analysis of genes encoding ornithine decarboxylase and amino acid permease in L. delbrueckii UFV H2b20 showed their high sequence identity (99%) and grouping with those of L. delbrueckii subsp. bulgaricus ATCC 11842. Exposure of L. delbrueckii UFV H2b20 cells in MRS pH 3.5 for 30 and 60 min caused a significant increase in expression of the gene encoding ornithine decarboxylase (up to 8.1 times higher when compared to the control treatment). Increased expression of the ornithine decarboxylase gene demonstrates its involvement in acid stress response in L. delbrueckii UFV H2b20, evidencing that the protein encoded by that gene could be involved in intracellular pH regulation. The results obtained show ornithine decarboxylation as a possible mechanism of adaptation to an acidic environmental condition, a desirable and necessary characteristic for probiotic cultures and certainly important to the survival and persistence of the L. delbrueckii UFV H2b20 in the human gastrointestinal tract.

  1. A Long Look at MCG-5-23-16 with NuSTAR . I. Relativistic Reflection and Coronal Properties

    Energy Technology Data Exchange (ETDEWEB)

    Zoghbi, Abderahmen; Miller, J. M. [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States); Matt, G. [Dipartimento di Matematica e Fisica, Universita degli Studi Roma Tre, via della Vasca Navale 84, I-00146 Roma (Italy); Lohfink, A. M. [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 OHA (United Kingdom); Walton, D. J.; Stern, D. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Ballantyne, D. R. [Center for Relativistic Astrophysics, School of Physics, Georgia Institute of Technology, Atlanta, GA 30332 (United States); García, J. A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Koss, M. J. [Institute for Astronomy, Department of Physics, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Farrah, D. [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States); Harrison, F. A. [Space Radiation Laboratory, California Institute of Technology, Pasadena, CA 91125 (United States); Boggs, S. E.; Craig, W. [Space Science Laboratory, University of California, Berkeley, California 94720 (United States); Christensen, F. E. [DTU Space. National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Hailey, C. J. [Columbia Astrophysics Laboratory, Columbia University, New York, New York 10027 (United States); Zhang, W. W., E-mail: abzoghbi@umich.edu [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States)

    2017-02-10

    MCG-5-23-16 was targeted in early 2015 with a half mega-second observing campaign using NuSTAR . Here we present the spectral analysis of these data sets along with an earlier observation and study the relativistic reflection and the primary coronal source. The data show strong reflection features in the form of both narrow and broad iron lines plus a Compton reflection hump. A cutoff energy is significantly detected in all exposures. The shape of the reflection spectrum does not change in the two years spanned by the observations, suggesting a stable geometry. A strong positive correlation is found between the cutoff energy and both the hard X-ray flux and spectral index. The measurements imply that the coronal plasma is not at the runaway electron–positron pair limit, and instead contains mostly electrons. The observed variability in the coronal properties is driven by a variable optical depth. A constant heating-to-cooling ratio is measured, implying that there is a feedback mechanism in which a significant fraction of the photons cooling the corona are due to reprocessed hard X-rays.

  2. A Long Look at MCG-5-23-16 with NuSTAR. I. Relativistic Reflection and Coronal Properties

    Science.gov (United States)

    Zoghbi, Abderahmen; Matt, G.; Miller, J. M.; Lohfink, A. M.; Walton, D. J.; Ballantyne, D. R.; Garcia, J. A.; Stern, D.; Koss, M. J.; Farrah, D.; hide

    2017-01-01

    MCG-5-23-16 was targeted in early 2015 with a half mega-second observing campaign using NuSTAR. Here we present the spectral analysis of these data sets along with an earlier observation and study the relativistic reflection and the primary coronal source. The data show strong reflection features in the form of both narrow and broad iron lines plus a Compton reflection hump. A cutoff energy is significantly detected in all exposures. The shape of the reflection spectrum does not change in the two years spanned by the observations, suggesting a stable geometry. A strong positive correlation is found between the cutoff energy and both the hard X-ray flux and spectral index. The measurements imply that the coronal plasma is not at the runaway electron-positron pair limit, and instead contains mostly electrons. The observed variability in the coronal properties is driven by a variable optical depth. A constant heating-to-cooling ratio is measured, implying that there is a feedback mechanism in which a significant fraction of the photons cooling the corona are due to reprocessed hard X-rays.

  3. EXTENDED NEUTRAL HYDROGEN IN THE ALIGNED SHELL GALAXIES Arp 230 AND MCG -5-7-1: FORMATION OF DISKS IN MERGING GALAXIES?

    Energy Technology Data Exchange (ETDEWEB)

    Schiminovich, David; Van Gorkom, J. H. [Department of Astronomy, Columbia University, New York, NY 10027 (United States); Van der Hulst, J. M. [Kapteyn Astronomical Institute, 9700-AV Groningen (Netherlands)

    2013-02-01

    As part of an ongoing study of the neutral hydrogen (H I) morphology and kinematics of 'shell' elliptical galaxies, we present Very Large Array observations of two shell galaxies with aligned shells, Arp 230 and MCG -5-7-1. Our data provide the first H I images of Arp 230 and deeper images of MCG -5-7-1 than previously reported. Optical images of Arp 230 reveal a bright, aligned, interleaved shell system, making it an ideal candidate for 'phase-wrapped' shell formation following a radial encounter with a smaller companion. The fainter, non-interleaved shells of MCG -5-7-1 do not clearly favor a particular formation scenario. The H I we detect in both galaxies extends to nearly the same projected distance as the optical shells. In Arp 230 this gas appears to be anti-correlated with the aligned shells, consistent with our expectations for phase-wrapped shells produced in a radial encounter. In MCG -5-7-1, we observe gas associated with the shells making a 'spatial wrapping' or looping scenario more plausible. Although the extended gas component in both galaxies is unevenly distributed, the gas kinematics are surprisingly regular, looking almost like complete disks in rotation. We use the H I kinematics and optical data to determine mass-to-light ratios M/L{sub B} of 2.4{sup +3.0}{sub -0.5} (at 13.5 kpc, 4.5 R{sub e} ) for Arp 230 and M/L{sub B} of 30 {+-} 7 (at 40 kpc, 7 R{sub e} ) in MCG -5-7-1. In both systems we find that this ratio changes as a function of radius, indicating the presence of a dark halo. By comparing orbital and precession timescales, we conclude that the potentials are slightly flattened. We infer a 5%-10% flattening for Arp 230 and less flattening in the case of MCG -5-7-1. Finally, we present images of the H I associated with the inner disk or (polar) ring of each galaxy and discuss possible explanations for their different present-day star formation rates. We detect total H I masses of 1.1 Multiplication-Sign 10

  4. Moessbauer spectroscopy on amorphous Fe/sub x/Ni/sub 80-x/B20 after neutron irradiation

    International Nuclear Information System (INIS)

    Sitek, J.; Miglierini, M.

    1985-01-01

    Amorphous Fe/sub x/Ni/sub 80-x/B 20 glassy alloys (x = 40, 50, 60, and 70) irradiated with fast neutrons in a fluence range of 10 14 to 10 19 cm -2 were investigated by Moessbauer spectroscopy. There were some significant changes in the Moessbauer spectrum parameters of the 10 19 cm -2 irradiated samples except Fe 40 Ni 40 B 20 . This corresponds to a change in the direction of the easy axis of magnetization. The measurements show that the resistance of the Fe-Ni-B system against neutron irradiation improves with increasing Ni content up to a certain point

  5. Unusual magnetoresistance in cubic B20 Fe0.85Co0.15Si chiral magnets

    Science.gov (United States)

    Huang, S. X.; Chen, Fei; Kang, Jian; Zang, Jiadong; Shu, G. J.; Chou, F. C.; Chien, C. L.

    2016-06-01

    The B20 chiral magnets with broken inversion symmetry and C4 rotation symmetry have attracted much attention. The broken inversion symmetry leads to the Dzyaloshinskii-Moriya that gives rise to the helical and Skyrmion states. We report the unusual magnetoresistance (MR) of B20 chiral magnet Fe0.85Co0.15Si that directly reveals the broken C4 rotation symmetry and shows the anisotropic scattering by Skyrmions with respect to the current directions. The intimacy between unusual MR and broken symmetry is well confirmed by theoretically studying an effective Hamiltonian with spin-orbit coupling. The unusual MR serves as a transport signature for the Skyrmion phase.

  6. Follicular development in a 7-day versus 4-day hormone-free interval with an oral contraceptive containing 20 mcg ethinyl estradiol and 1 mg norethindrone acetate.

    Science.gov (United States)

    Rible, Radhika D; Taylor, DeShawn; Wilson, Melissa L; Stanczyk, Frank Z; Mishell, Daniel R

    2009-03-01

    Combined oral contraceptive (COC) formulations with 20 mcg ethinyl estradiol (EE) have a greater incidence of ovarian hormone production and follicular development, which can be managed by shortening the number of hormone-free days per COC cycle. This study evaluates differences in follicular development during a 7-day versus 4-day hormone-free interval in a COC regimen with 20 mcg EE and 1 mg norethindrone acetate. Forty-one healthy women were randomized in an open-label fashion to this formulation in either a 24/4 or a 21/7 day regimen for three cycles. Estradiol, progesterone, follicle-stimulating hormone, luteinizing hormone and inhibin B were measured daily from Cycle 2, Day 21 to Cycle 3, Day 3 and on Day 7 of Cycle 3. Follicular diameter and Hoogland score were calculated on Cycle 2, Days 21, 24 and 28 and Cycle 3, Days 3 and 7. Sixty-six percent of subjects in the 21/7 group and 70% of the subjects in the 24/4 group developed a follicle greater than 10 mm diameter. Ovarian steroid hormone levels, Hoogland scores and bleeding patterns were not statistically significant between the groups. In contrast to prior studies, this analysis suggests no difference in follicle development or bleeding patterns among women receiving a 21/7 or 24/4 regimen of a 20-mcg EE/1-mg norethindrone acetate COC.

  7. Premenstrual dysphoric disorder symptom cluster improvement by cycle with the combined oral contraceptive ethinylestradiol 20 mcg plus drospirenone 3 mg administered in a 24/4 regimen.

    Science.gov (United States)

    Marr, Joachim; Niknian, Minoo; Shulman, Lee P; Lynen, Richard

    2011-07-01

    A combined oral contraceptive comprising ethinylestradiol (EE) 20 mcg/drospirenone 3 mg in a 24/4 regimen has been clinically shown to alleviate the symptoms associated with premenstrual dysphoric disorder (PMDD). However, previous studies did not report data according to cycle-by-cycle improvement. This was a subanalysis of a Phase III, double-blind, multicenter, United States-based study. Women with confirmed PMDD were randomized to EE 20 mcg/drospirenone 3 mg 24/4 or placebo for three treatment cycles. Ten of the 21 emotional and physical items on the Daily Record of Severity of Problems scale were grouped to define three symptom clusters: (a) negative emotions, (b) food cravings and (c) water retention-related symptoms. The change from baseline at each treatment cycle was compared between groups using a weighted analysis of covariance model. The full analysis set comprised 449 women. Daily Record of Severity of Problems scores for each symptom cluster were significantly reduced from baseline with both EE 20 mcg/drospirenone 3 mg 24/4 and placebo (pemotions, food cravings and water retention-related symptoms to a significantly greater extent than placebo during all three cycles of treatment. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Isothermal structural relaxation of Fe40Ni40B20 metallic glass in the relaxation times spectrum model

    NARCIS (Netherlands)

    Csach, K; Haruyama, O; Kasardova, A; Ocelik, Vaclav

    1997-01-01

    The structural relaxation of amorphous as-quenched Fe40Ni40B20 sample was investigated during isothermal annealing at temperatures close to 400 degrees C by: (i) the residual electrical resistance measured at liquid N-2 temperature; (ii) the in-situ electrical resistance; and (iii) the length

  9. Increased expression of clp genes in Lactobacillus delbrueckii UFV H2b20 exposed to acid stress and bile salts.

    Science.gov (United States)

    Ferreira, A B; De Oliveira, M N V; Freitas, F S; Alfenas-Zerbini, P; Da Silva, D F; De Queiroz, M V; Borges, A C; De Moraes, C A

    2013-12-01

    The ability to survive in harsh environments is an important criterion to select potential probiotics strains. The objective of this study was to identify and carry out phylogenetic and expression analysis by quantitative real-time PCR of the clpP, clpE, clpL and clpX genes in the probiotic strain Lactobacillus delbrueckii UFV H2b20 exposed to the conditions prevailing in the gastrointestinal tract (GIT). Phylogenetic trees reconstructed by Bayesian inference showed that the L. delbrueckii UFV H2b20 clpP, clpL and clpE genes and the ones from L. delbrueckii ATCC 11842 were grouped. The exposure of cells to MRS broth of pH 3.5 for 30 and 60 min resulted in an increased expression of the four genes. Exposure of the L. delbrueckii UFV H2b20 cells for 30 and 60 min to MRS broth containing 0.1% bile salts increased the expression of the clpP and clpE genes, while the expression level of the clpL and clpX genes increased only after 30 min of exposure. The involvement of the studied genes in the responses to acid stress and bile salts suggests a possible central role of these genes in the survival of L. delbrueckii UFV H2b20 during the passage through the GIT, a characteristic necessary for probiotic strains.

  10. Genes involved in protein metabolism of the probiotic lactic acid bacterium Lactobacillus delbrueckii UFV H2b20.

    Science.gov (United States)

    Do Carmo, A P; da Silva, D F; De Oliveira, M N V; Borges, A C; De Carvalho, A F; De Moraes, C A

    2011-09-01

    A basic requirement for the prediction of the potential use of lactic acid bacteria (LAB) in the dairy industry is the identification of specific genes involved in flavour-forming pathways. The probiotic Lactobacillus delbrueckii UFV H2b20 was submitted to a genetic characterisation and phylogenetic analysis of genes involved in protein catabolism. Eight genes belonging to this system were identified, which possess a closely phylogenetic relationship to NCFM strains representative, as it was demonstrated for oppC and oppBII, encoding oligopeptide transport system components. PepC, PepN, and PepX might be essential for growth of LAB, probiotic or not, since the correspondent genes are always present, including in L. delbrueckii UFV H2b20 genome. For pepX gene, a probable link between carbohydrate catabolism and PepX expression may exists, where it is regulated by PepR1/CcpA-like, a common feature between Lactobacillus strains and also in L. delbrueckii UFV H2b20. The well conserved evolutionary history of the ilvE gene is evidence that the pathways leading to branched-chain amino acid degradation, such as isoleucine and valine, are similar among L. delbrueckii subsp. bulgaricus strains and L. delbrueckii UFV H2b20. Thus, the involvement of succinate in flavour formation can be attributed to IlvE activity. The presence of aminopeptidase G in L. delbrueckii UFV H2b20 genome, which is absent in several strains, might improve the proteolytic activity and effectiveness. The nucleotide sequence encoding PepG revealed that it is a cysteine endopeptidase, belonging to Peptidase C1 superfamily; sequence analysis showed 99% identity with L. delbrueckii subsp. bulgaricus ATCC 11842 pepG, whereas protein sequence analysis revealed 100% similarity with PepG from the same organism. The present study proposes a schematic model to explain how the proteolytic system of the probiotic L. delbrueckii UFV H2b20 works, based on the components identified so far.

  11. Unusual magnetoresistance in cubic B20 Fe0.85Co0.15Si chiral magnets

    International Nuclear Information System (INIS)

    Huang, S X; Chen, Fei; Zang, Jiadong; Chien, C L; Kang, Jian; Shu, G J; Chou, F C

    2016-01-01

    The B20 chiral magnets with broken inversion symmetry and C 4 rotation symmetry have attracted much attention. The broken inversion symmetry leads to the Dzyaloshinskii–Moriya that gives rise to the helical and Skyrmion states. We report the unusual magnetoresistance (MR) of B20 chiral magnet Fe 0.85 Co 0.15 Si that directly reveals the broken C 4 rotation symmetry and shows the anisotropic scattering by Skyrmions with respect to the current directions. The intimacy between unusual MR and broken symmetry is well confirmed by theoretically studying an effective Hamiltonian with spin–orbit coupling. The unusual MR serves as a transport signature for the Skyrmion phase. (paper)

  12. Survival of Lactobacillus delbrueckii UFV H2b20 in fermented milk under simulated gastric and intestinal conditions.

    Science.gov (United States)

    da Conceição, L L; Leandro, E S; Freitas, F S; de Oliveira, M N V; Ferreira-Machado, A B; Borges, A C; de Moraes, C A

    2013-09-01

    The survival of Lactobacillus delbrueckii UFV H2b20 was assessed in fermented milk, both during the storage period and after exposure to simulated gastric and intestinal juices, as well the detection of the gene fbpA involved in adherence to human gastrointestinal tract. L. delbrueckii UFV H2b20 remained stable and viable for 28 days under refrigerated storage conditions. After one day of storage, that strain exhibited a one-log population reduction following exposure in tandem to simulated gastric and intestinal juices. After 14 days of storage, a two-log reduction was observed following 90 min of exposure to the simulated gastric conditions. However, the strain did not survive following exposure to the simulated intestinal juice. The observed tolerance to storage conditions and resistance to the simulated gastric and intestinal conditions confirm the potential use of L. delbrueckii UFV H2b20 as a probiotic, which is further reinforced by the detection of fbpA in this strain.

  13. Impact of a Diesel High Pressure Common Rail Fuel System and Onboard Vehicle Storage on B20 Biodiesel Blend Stability

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, Earl; McCormick, Robert L.; Sigelko, Jenny; Johnson, Stuart; Zickmann, Stefan; Lopes, Shailesh; Gault, Roger; Slade, David

    2016-04-01

    Adoption of high-pressure common-rail (HPCR) fuel systems, which subject diesel fuels to higher temperatures and pressures, has brought into question the efficacy of ASTM International specifications for biodiesel and biodiesel blend oxidation stability, as well as the lack of any stability parameter for diesel fuel. A controlled experiment was developed to investigate the impact of a light-duty diesel HPCR fuel system on the stability of 20% biodiesel (B20) blends under conditions of intermittent use and long-term storage in a relatively hot and dry climate. B20 samples with Rancimat induction periods (IPs) near the current 6.0-hour minimum specification (6.5 hr) and roughly double the ASTM specification (13.5 hr) were prepared from a conventional diesel and a highly unsaturated biodiesel. Four 2011 model year Volkswagen Passats equipped with HPCR fuel injection systems were utilized: one on B0, two on B20-6.5 hr, and one on B20-13.5 hr. Each vehicle was operated over a one-hour drive cycle in a hot running loss test cell to initially stress the fuel. The cars were then kept at Volkswagen's Arizona Proving Ground for two (35 degrees C average daily maximum) to six months (26 degrees C average daily maximum). The fuel was then stressed again by running a portion of the one-hour dynamometer drive cycle (limited by the amount of fuel in the tank). Fuel rail and fuel tank samples were analyzed for IP, acid number, peroxide content, polymer content, and ester profile. The HPCR fuel pumps were removed, dismantled, and inspected for deposits or abnormal wear. Analysis of fuels collected during initial dynamometer tests showed no impact of exposure to HPCR conditions. Long-term storage with intermittent use showed that IP remained above 3 hours, acid number below 0.3 mg KOH/g, peroxides low, no change in ester profile, and no production of polymers. Final dynamometer tests produced only small changes in fuel properties. Inspection of the HPCR fuel pumps revealed no

  14. DISCOVERY OF Fe Kα X-RAY REVERBERATION AROUND THE BLACK HOLES IN MCG-5-23-16 AND NGC 7314

    International Nuclear Information System (INIS)

    Zoghbi, A.; Reynolds, C.; Cackett, E. M.; Miniutti, G.; Kara, E.; Fabian, A. C.

    2013-01-01

    Several X-ray observations have recently revealed the presence of reverberation time delays between spectral components in active galactic nuclei. Most of the observed lags are between the power-law Comptonization component, seen directly, and the soft excess produced by reflection in the vicinity of the black hole. NGC 4151 was the first object to show these lags in the iron K band. Here, we report the discovery of reverberation lags in the Fe K band in two other sources: MCG-5-23-16 and NGC 7314. In both objects, the 6-7 keV band, where the Fe Kα line peaks, lags the bands at lower and higher energies with a time delay of ∼1 ks. These lags are unlikely to be due to the narrow Fe Kα line. They are fully consistent with reverberation of the relativistically broadened iron Kα line. The measured lags, their time scale, and spectral modeling indicate that most of the radiation is emitted at ∼5 and 24 gravitational radii for MCG-5-23-16 and NGC 7314, respectively.

  15. DISCOVERY OF Fe K{alpha} X-RAY REVERBERATION AROUND THE BLACK HOLES IN MCG-5-23-16 AND NGC 7314

    Energy Technology Data Exchange (ETDEWEB)

    Zoghbi, A.; Reynolds, C. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Cackett, E. M. [Department of Physics and Astronomy, Wayne State University, 666 W. Hancock St, Detroit, MI 48201 (United States); Miniutti, G. [Centro de Astrobiologia (CSIC-INTA), Dep. de Astrosica, P.O. Box 78, E-28691 Villanueva de la Canada, Madrid (Spain); Kara, E.; Fabian, A. C., E-mail: azoghbi@astro.umd.edu [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom)

    2013-04-20

    Several X-ray observations have recently revealed the presence of reverberation time delays between spectral components in active galactic nuclei. Most of the observed lags are between the power-law Comptonization component, seen directly, and the soft excess produced by reflection in the vicinity of the black hole. NGC 4151 was the first object to show these lags in the iron K band. Here, we report the discovery of reverberation lags in the Fe K band in two other sources: MCG-5-23-16 and NGC 7314. In both objects, the 6-7 keV band, where the Fe K{alpha} line peaks, lags the bands at lower and higher energies with a time delay of {approx}1 ks. These lags are unlikely to be due to the narrow Fe K{alpha} line. They are fully consistent with reverberation of the relativistically broadened iron K{alpha} line. The measured lags, their time scale, and spectral modeling indicate that most of the radiation is emitted at {approx}5 and 24 gravitational radii for MCG-5-23-16 and NGC 7314, respectively.

  16. Electrical, thermal and magnetic behaviour of the metallic glass Fe80B20 in the crystallization process

    International Nuclear Information System (INIS)

    Isalgue, A.; Cusido, J.A.

    1986-01-01

    The thermal, electrical DC conductivity and magnetic properties have been studied in the crystallization process of the metallic glass Fe 80 B 20 (Metglass 2605) induced by heat treatment. The electrical and thermal conductivity, the coercive force and the remanence are strongly affected with the crystallization of the glass. Two steps can be dicerned from the magnetic measurements; the differences between the two steps are interpreted in the basis of the ''spherulite-type'', grown of Fe 3 B in the first crystallization step and the aparition of Fe 2 B in the second step. (author)

  17. Magnetic and Mössbauer studies of amorphous Fe 72- xY xHo 8B 20 alloys

    Science.gov (United States)

    Krishnan, R.; Driouch, L.; Lassri, H.; Dumond, Y.; Ajan, Antony; Shringi, S. N.; Prasad, Shiva

    1996-11-01

    We have carried out magnetic and Mössbauer studies of amorphous Fe 72- xY xHo 8B 20 alloys. The Fe moment decreases with the addition of Y and a magnetic compensation occurs at 4 K for x = 16. The temperature and field dependences of the magnetization have been interpreted using the mean field theory and Chudnovsky's model, respectively. These analyses yield some interesting parameters such as the random anisotropy, the exchange interactions JFe-Fe, JFe-Ho, etc. The Mössbauer studies show that the average hyperfine field decreases linearly with the addition of Y, in accordance with the decrease in the Fe moment.

  18. Field-induced non-collinear magnetic structures in amorphous Co80-xDy xB20 alloys

    International Nuclear Information System (INIS)

    Annouar, F.; Roky, K.; Lassri, H.; Elmoussaoui, A.; Driouch, L.; Ayadi, M.; Omri, M.; Krishnan, R.

    2005-01-01

    Amorphous Co 80-x Dy x B 20 alloys have been prepared by melt spinning technique and their magnetic properties have been studied. The mean field theory has been used to explain the temperature dependence of the magnetization. High-field magnetization studies performed at 4.2 K in magnetic fields up to 38 T have revealed, for samples with stoichiometry close to that of a compensated ferrimagnet, a magnetic behavior that is characteristic of a non-collinear magnetic structure of the Dy and Co sublattices. From the non-collinear regime the exchange interactions between the Co and Dy magnetic sublattices and the magnetic anisotropy constants have been evaluated

  19. FP-(LAPW + lo study of mechanical stability and electronic behavior of CoGe in B20 structure

    Directory of Open Access Journals (Sweden)

    Timaoui M. A.

    2017-10-01

    Full Text Available The aim of this work is a theoretical study of structural, elastic, electronic and thermal properties of CoGe compound in B20 structure using All-electron self-consistent Full Potential Augmented Plane Waves plus local orbital “FP(LAPW + lo” within the framework of Density Functional Theory DFT. GGA-PBEsol is the exchange-correlation potential selected in this work. This choice is motivated by the success of this functional in predicting structural and mechanical properties of solids. The values obtained by the study of structural properties are in very good agreement with those found previously. In this work, the elastic constants have been predicted for the first time and the obtained values confirm the mechanical stability of the CoGe compound in its B20 structure. The electronic part of this work shows that CoGe has metallic behavior with a mixed bonding between cobalt and germanium of covalent-metallic type. The effect of temperature and hydrostatic pressure on the lattice parameter - a0, heat capacity at constant volume - CV, thermal expansion coefficient - α and entropy - S of the CoGe have been studied using Debye model.

  20. MCG101-induced cancer anorexia-cachexia features altered expression of hypothalamic Nucb2 and Cartpt and increased plasma levels of cocaine- and amphetamine-regulated transcript peptides.

    Science.gov (United States)

    Burgos, Jonathan R; Iresjö, Britt-Marie; Smedh, Ulrika

    2016-04-01

    The aim of the present study was to explore central and peripheral host responses to an anorexia-cachexia producing tumor. We focused on neuroendocrine anorexigenic signals in the hypothalamus, brainstem, pituitary and from the tumor per se. Expression of mRNA for corticotropin-releasing hormone (CRH), cocaine- and amphetamine-regulated transcript (CART), nesfatin-1, thyrotropin (TSH) and the TSH receptor were explored. In addition, we examined changes in plasma TSH, CART peptides (CARTp) and serum amyloid P component (SAP). C57BL/6 mice were implanted with MCG101 tumors or sham-treated. A sham-implanted, pair‑fed (PF) group was included to delineate between primary tumor and secondary effects from reduced feeding. Food intake and body weight were measured daily. mRNA levels from microdissected mouse brain samples were assayed using qPCR, and plasma levels were determined using ELISA. MCG101 tumors expectedly induced anorexia and loss of body weight. Tumor-bearing (TB) mice exhibited an increase in nesfatin-1 mRNA as well as a decrease in CART mRNA in the paraventricular area (PVN). The CART mRNA response was secondary to reduced caloric intake whereas nesfatin-1 mRNA appeared to be tumor-specifically induced. In the pituitary, CART and TSH mRNA were upregulated in the TB and PF animals compared to the freely fed controls. Plasma levels for CARTp were significantly elevated in TB but not PF mice whereas levels of TSH were unaffected. The plasma CARTp response was correlated to the degree of inflammation represented by SAP. The increase in nesfatin-1 mRNA in the PVN highlights nesfatin-1 as a plausible candidate for causing tumor-induced anorexia. CART mRNA expression in the PVN is likely an adaptation to reduced caloric intake secondary to a cancer anorexia-cachexia syndrome (CACS)‑inducing tumor. The MCG101 tumor did not express CART mRNA, thus the elevation of plasma CARTp is host derived and likely driven by inflammation.

  1. Change of electrical resistivity and Young's modulus during crystallization of amorphous Fe40Ni40B20

    International Nuclear Information System (INIS)

    Stel, J. van der; Veldhuizen, H.B. van; Koebrugge, G.W.; Sietsma, J.; Beukel, A. van den

    1989-01-01

    The kinetics of crystallization of amorphous Fe 40 Ni 40 B 20 is studied by measuring isothermal changes of the electrical resistivity and Young's modulus in the temperature range 600 to 700 K. The results satisfy very well the Johnson-Mehl-Avrami equation for phase transformations with a constant activation energy of 317 kJ/mol and a constant Avrami exponent n ∼ 2. This result is interpreted as two-dimensional growth of pre-existing nuclei which become as thick as the specimen in an early stage of crystallization. The relative change in electrical resistivity upon crystallization strongly depends on the measuring temperature T m , varying from 47% at T m = 77 K to 5% at T m = 600 K. It extrapolates to zero at T m ∼ 700 K. (author)

  2. Partial characterization of ribosomal operons of Lactobacillus delbrueckii UFV H2b20 Caracterização parcial de operons ribossomais de Lactobacillus delbrueckii UFV H2b20

    Directory of Open Access Journals (Sweden)

    Juliana Teixeira de Magalhães

    2005-06-01

    Full Text Available Ribosomal operons are great tools for microbe community characterization and for microorganisms relationship study, particularly in the case of the acid lactic bacteria. The ribosomal operon of the probiotic strain Lactobacillus delbrueckii UFV H2b20 was partially characterized. A genomic library of this strain was constructed and the clones with partial ribosomal operon were sub-cloned using the shot-gun method for subsequent sequencing with the forward primer. The sequence analysis revealed that the 3' end of the rDNA 16S was following by the short spacer region 1 (16S-23S and that the 3' end of the rDNA 23S was following by the short spacer region 2 (23S-5S, which preceded the rDNA 5S. In the flanking region of the rDNA 5S gene of this operon rrn, a region encoding six tRNAs was detected.Operons ribossomais têm sido instrumentos importantes na caracterização de comunidades microbianas e no estudo de relacionamentos entre microrganismos, principalmente em bactérias do ácido láctico. Operons ribossomais da linhagem probiótica, Lactobacillus delbrueckii UFV H2b20, foram parcialmente caracterizados. Um banco genômico da linhagem foi construído e os clones, contendo parte do operon ribossomal, foram subclonados pelo método de "shot gun", para em seguida serem seqüenciados com primer "forward". As seqüências indicaram a presença da extremidade 3' do rDNA 16S seguida da região espaçadora curta 1 (16S-23S e a presença da extremidade 3' do rDNA 23S seguido da região espaçadora 2 (23S-5S, que por sua vez precedia o rDNA 5S. Adjacente ao gene rDNA 5S deste operon rrn uma região codificadora de 6 tRNAs foi detectada.

  3. Studying nearest neighbor correlations by atom probe tomography (APT) in metallic glasses as exemplified for Fe40Ni40B20 glassy ribbons

    KAUST Repository

    Shariq, Ahmed; Al-Kassab, Talaat; Kirchheim, Reiner

    2012-01-01

    resolution of the analytical technique. However, fitting Gaussian distributions to the distribution of atomic distances yields average distances with statistical uncertainties of 2 to 3 hundredth of an Angstrom. Fe 40Ni40B20 metallic glass ribbons

  4. Multi-jump magnetic switching in ion-beam sputtered amorphous Co20Fe60B20 thin films

    International Nuclear Information System (INIS)

    Raju, M.; Chaudhary, Sujeet; Pandya, D. K.

    2013-01-01

    Unconventional multi-jump magnetization reversal and significant in-plane uniaxial magnetic anisotropy (UMA) in the ion-beam sputtered amorphous Co 20 Fe 60 B 20 (5–75 nm) thin films grown on Si/amorphous SiO 2 are reported. While such multi-jump behavior is observed in CoFeB(10 nm) film when the magnetic field is applied at 10°–20° away from the easy-axis, the same is observed in CoFeB(12.5 nm) film when the magnetic field is 45°–55° away from easy-axis. Unlike the previous reports of multi-jump switching in epitaxial films, their observance in the present case of amorphous CoFeB is remarkable. This multi-jump switching is found to disappear when the films are crystallized by annealing at 420 °C. The deposition geometry and the energy of the sputtered species appear to intrinsically induce a kind of bond orientation anisotropy in the films, which leads to the UMA in the as-grown amorphous CoFeB films. Exploitation of such multi-jump switching in amorphous CoFeB thin films could be of technological significance because of their applications in spintronic devices

  5. Influence of (TiC+TiB) on the microstructure and tensile properties of Ti-B20 matrix alloy

    Energy Technology Data Exchange (ETDEWEB)

    Rahoma, H.K.S. [National Key Laboratory of Science and Technology on Precision Heat Processing of Metals, Harbin Institute of Technology, Harbin 150001 (China); Chen, Y.Y., E-mail: yychen@hit.edu.cn [National Key Laboratory of Science and Technology on Precision Heat Processing of Metals, Harbin Institute of Technology, Harbin 150001 (China); State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Wang, X.P.; Xiao, S.L. [National Key Laboratory of Science and Technology on Precision Heat Processing of Metals, Harbin Institute of Technology, Harbin 150001 (China)

    2015-04-05

    Highlights: • After forging, the microstructure was significantly refined and uniform. • The presence of carbide and boride also led to uniform and finer precipitation of α during aging as compared to the matrix alloy. • The size of secondary α phase increased with the increase of aging temperature. This trend leads to the decrease of strength and the increase of ductility. - Abstract: A hybrid of (TiB+TiC) reinforced beta titanium matrix (Ti-B20) were produced by non-consumable arc-melting technology and hot-forging. Microstructures of the composites were observed by optical microscopy (OM), transmission electron microscope (TEM) and scanning electron microscopy (SEM). The results show that both the TiB whiskers and TiC particles tend to segregate at β boundaries. The β grain size and secondary α lath width are refined by reinforcements and aging treatment. Evolution of tensile properties shows that enhancement in yield strength and ultimate tensile strength with the addition of reinforcements, as well as the remarkable increase in the ductility can be attributed to aging treatment at 600 °C and 650 °C. The size of secondary α phase increased with the increase of aging temperature. This trend leads to the decrease of strength and the increase of ductility to get good balance of properties. The fracture mechanism of the composite can be attributed to the cracking of the reinforcements.

  6. Anti-inflammatory effects of salmeterol/fluticasone propionate 50/250 mcg combination therapy in Japanese patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Asai K

    2015-04-01

    Full Text Available Kazuhisa Asai,1 Akihiro Kobayashi,2 Yukio Makihara,3 Malcolm Johnson4 1Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan; 2Biomedical Data Sciences, 3Medical Affairs Respiratory Department, GlaxoSmithKline, Tokyo, Japan; 4Respiratory Global Franchise, GlaxoSmithKline, Uxbridge, UK Purpose: Using sputum neutrophils as the primary measure, and other inflammation biomarkers, this study evaluated the anti-inflammatory effects of the combination salmeterol 50 mcg and fluticasone propionate 250 mcg (SFC 250 in Japanese patients with chronic obstructive pulmonary disease (COPD. Patients and methods: Patients were treated in a randomized, double-blind, parallel group, placebo-controlled trial with SFC 250 twice daily (n=26 or placebo (n=26 for 12 weeks. At the start and end of treatment, inflammation biomarkers (sputum and serum, lung function, and health status (COPD Assessment Test [CAT] questionnaire were measured. Results: Although a numerical decrease in differential neutrophil count was observed from baseline, SFC 250 did not significantly reduce sputum neutrophils compared with placebo, nor were there significant changes from baseline in the other biomarkers (sputum or serum, lung function, or CAT, versus placebo. Squamous epithelial cell contamination in some sputum samples rendered them unacceptable for analysis, which reduced the sample size to n=19 (SFC 250 and n=10 (placebo. However, inclusion of contaminated samples did not affect the overall trend of the outcome. Ad hoc bootstrap statistical analysis showed a 27.9% (SFC 250 and 1.3% (placebo decrease in sputum neutrophils. Sputum IL-8 decreased by 43.2% after SFC 250 but increased by 48.3% with placebo. Responder analyses showed 42% of patients had ≥20% decrease in neutrophils from baseline; and 47% of patients had a ≥200 pg/mL change in sputum IL-8 following SFC 250 versus 20% after placebo; both changes are considered clinically

  7. An experimental study on usage of plastic oil and B20 algae biodiesel blend as substitute fuel to diesel engine.

    Science.gov (United States)

    Ramesha, D K; Kumara, G Prema; Lalsaheb; Mohammed, Aamir V T; Mohammad, Haseeb A; Kasma, Mufteeb Ain

    2016-05-01

    Usage of plastics has been ever increasing and now poses a tremendous threat to the environment. Millions of tons of plastics are produced annually worldwide, and the waste products have become a common feature at overflowing bins and landfills. The process of converting waste plastic into value-added fuels finds a feasible solution for recycling of plastics. Thus, two universal problems such as problems of waste plastic management and problems of fuel shortage are being tackled simultaneously. Converting waste plastics into fuel holds great promise for both the environmental and economic scenarios. In order to carry out the study on plastic wastes, the pyrolysis process was used. Pyrolysis runs without oxygen and in high temperature of about 250-300 °C. The fuel obtained from plastics is blended with B20 algae oil, which is a biodiesel obtained from microalgae. For conducting the various experiments, a 10-HP single-cylinder four-stroke direct-injection water-cooled diesel engine is employed. The engine is made to run at 1500 rpm and the load is varied gradually from 0 to 100 %. The performance, emission and combustion characteristics are observed. The BTE was observed to be higher with respect to diesel for plastic-biodiesel blend and biodiesel blend by 15.7 and 12.9 %, respectively, at full load. For plastic-biodiesel blend, the emission of UBHC and CO decreases with a slight increase in NO x as compared to diesel. It reveals that fuel properties are comparable with petroleum products. Also, the process of converting plastic waste to fuel has now turned the problems into an opportunity to make wealth from waste.

  8. The effect of drospirenone (3 mg) with ethinyl estradiol (30 mcg) containing pills on ovarian blood flows in women with polycystic ovary syndrome: a case controlled study.

    Science.gov (United States)

    Okyay, Emre; Gode, Funda; Acet, Ferruh; Bodur, Taylan; Cagliyan, Erkan; Sahan, Ceyda; Posaci, Cemal; Gulekli, Bulent

    2014-09-01

    To evaluate whether oral contraceptive pill (OCP) therapy has any effects on ovarian stromal blood flow by using pulsed and color Doppler at the end of 3 months follow-up period of OCP-users and non-users with or without polycystic ovary syndrome (PCOS). 200 patients were included in the study. The patients were designed into four groups as follows; Group 1: PCOS patients that received OCP containing 30 mcg ethinyl estradiol (EE) plus 3mg drospirenone for 3 months (DRP n=50); Group 2: PCOS patients that received no medication (n=50); Group 3: Healthy controls that received OCP (EE plus DRP) (n=50); Group 4: healthy controls that received no medication (n=50). Resistance index (RI) and pulsatility index (PI) of both ovarian arteries, hormonal, anthropometric and biochemical parameters were assessed before and after 3 months. There was a significant increament in RI and PI of both ovarian arteries in healthy controls (Group 3) and in women with PCOS (Group 1) who received OCP (povaries remained unchanged in all untreated women with or without PCOS (Groups 2 and 4). OCP therapy reduced ovarian vascularization in both PCOS and healthy users after 3 months of therapy and this decrease is especially noticeable in women with PCOS. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Remaining Sites Verification Package for the 100-B-20, 1716-B Maintenance Garage Underground Tank, Waste Site Reclassification Form 2006-019

    Energy Technology Data Exchange (ETDEWEB)

    L. M. Dittmer

    2006-09-27

    The 100-B-20 waste site, located in the 100-BC-1 Operable Unit of the Hanford Site, consisted of an underground oil tank that once serviced the 1716-B Maintenance Garage. The selected action for the 100-B-20 waste site involved removal of the oil tanks and their contents and demonstrating through confirmatory sampling that all cleanup goals have been met. In accordance with this evaluation, a reclassification status of interim closed out has been determined. The results demonstrate that the site will support future unrestricted land uses that can be represented by a rural-residential scenario. These results also show that residual concentrations support unrestricted future use of shallow zone soil and that contaminant levels remaining in the soil are protective of groundwater and the Columbia River.

  10. Remaining Sites Verification Package for the 100-B-20, 1716-B Maintenance Garage Underground Tank. Attachment to Waste Site Reclassification Form 2006-019

    International Nuclear Information System (INIS)

    Dittmer, L.M.

    2006-01-01

    The 100-B-20 waste site, located in the 100-BC-1 Operable Unit of the Hanford Site, consisted of an underground oil tank that once serviced the 1716-B Maintenance Garage. The selected action for the 100-B-20 waste site involved removal of the oil tanks and their contents and demonstrating through confirmatory sampling that all cleanup goals have been met. In accordance with this evaluation, a reclassification status of interim closed out has been determined. The results demonstrate that the site will support future unrestricted land uses that can be represented by a rural-residential scenario. These results also show that residual concentrations support unrestricted future use of shallow zone soil and that contaminant levels remaining in the soil are protective of groundwater and the Columbia River

  11. Genes involved in lactose catabolism and organic acid production during growth of Lactobacillus delbrueckii UFV H2b20 in skimmed milk.

    Science.gov (United States)

    Do Carmo, A P; De Oliveira, M N V; Da Silva, D F; Castro, S B; Borges, A C; De Carvalho, A F; De Moraes, C A

    2012-03-01

    There are three main reasons for using lactic acid bacteria (LAB) as starter cultures in industrial food fermentation processes: food preservation due to lactic acid production; flavour formation due to a range of organic molecules derived from sugar, lipid and protein catabolism; and probiotic properties attributed to some strains of LAB, mainly of lactobacilli. The aim of this study was to identify some genes involved in lactose metabolism of the probiotic Lactobacillus delbrueckii UFV H2b20, and analyse its organic acid production during growth in skimmed milk. The following genes were identified, encoding the respective enzymes: ldh - lactate dehydrogenase, adhE - Ldb1707 acetaldehyde dehydrogenase, and ccpA-pepR1 - catabolite control protein A. It was observed that L. delbrueckii UFV H2b20 cultivated in different media has the unexpected ability to catabolyse galactose, and to produce high amounts of succinic acid, which was absent in the beginning, raising doubts about the subspecies in question. The phylogenetic analyses showed that this strain can be compared physiologically to L. delbrueckii subsp. bulgaricus and L. delbrueckii subsp. lactis, which are able to degrade lactose and can grow in milk. L. delbrueckii UFV H2b20 sequences have grouped with L. delbrueckii subsp. bulgaricus ATCC 11842 and L. delbrueckii subsp. bulgaricus ATCC BAA-365, strengthening the classification of this probiotic strain in the NCFM group proposed by a previous study. Additionally, L. delbrueckii UFV H2b20 presented an evolutionary pattern closer to that of probiotic Lactobacillus acidophilus NCFM, corroborating the suggestion that this strain might be considered as a new and unusual subspecies among L. delbrueckii subspecies, the first one identified as a probiotic. In addition, its unusual ability to metabolise galactose, which was significantly consumed in the fermentation medium, might be exploited to produce low-browning probiotic Mozzarella cheeses, a desirable property

  12. Molecular beam epitaxy growth of [CrGe/MnGe/FeGe] superlattices: Toward artificial B20 skyrmion materials with tunable interactions

    Science.gov (United States)

    Ahmed, Adam S.; Esser, Bryan D.; Rowland, James; McComb, David W.; Kawakami, Roland K.

    2017-06-01

    Skyrmions are localized magnetic spin textures whose stability has been shown theoretically to depend on material parameters including bulk Dresselhaus spin orbit coupling (SOC), interfacial Rashba SOC, and magnetic anisotropy. Here, we establish the growth of a new class of artificial skyrmion materials, namely B20 superlattices, where these parameters could be systematically tuned. Specifically, we report the successful growth of B20 superlattices comprised of single crystal thin films of FeGe, MnGe, and CrGe on Si(1 1 1) substrates. Thin films and superlattices are grown by molecular beam epitaxy and are characterized through a combination of reflection high energy electron diffraction, X-ray diffraction, and cross-sectional scanning transmission electron microscopy (STEM). X-ray energy dispersive spectroscopy (XEDS) distinguishes layers by elemental mapping and indicates good interface quality with relatively low levels of intermixing in the [CrGe/MnGe/FeGe] superlattice. This demonstration of epitaxial, single-crystalline B20 superlattices is a significant advance toward tunable skyrmion systems for fundamental scientific studies and applications in magnetic storage and logic.

  13. A STUDY COMPARING DIFFERENT CONCENTRATIONS OF ROPIVACAINE 0.125% VS. 0.2%, WHEN GIVEN WITH FENTANYL 2 MCG/ML FOR EPIDURAL LABOUR ANALGESIA

    Directory of Open Access Journals (Sweden)

    Vindhya K

    2017-07-01

    of ropivacaine (0.2% and 0.125% with fentanyl were effective in producing epidural labor analgesia. 0.2% concentration was found superior in prolonging the duration, lesser breakthrough pain requiring lesser top-ups, and a lesser consumption of opioids. Our study favors, the use of 10ml of 0.2% ropivacaine with 2mcg/ml fentanyl over 0.125% ropivacaine for labor analgesia.

  14. Dependence of magnetic anisotropy on MgO sputtering pressure in Co20Fe60B20/MgO stacks

    Science.gov (United States)

    Kaidatzis, A.; Serletis, C.; Niarchos, D.

    2017-10-01

    We investigated the dependence of magnetic anisotropy of Ta/Co20Fe60B20/MgO stacks on the Ar partial pressure during MgO deposition, in the range between 0.5 and 15 mTorr. The stacks are studied before and after annealing at 300°C and it is shown that magnetic anisotropy significantly depends on Ar partial pressure. High pressure results in stacks with very low perpendicular magnetic anisotropy even after annealing, while low pressure results in stacks with perpendicular anisotropy even at the as-deposited state. A monotonic increase of magnetic anisotropy energy is observed as Ar partial pressure is decreased.

  15. Effect of hydridation on structure of amorphous and amorphous-crystalline Fe40Ni40B20 and Co70Fe5Si15B10 bands

    International Nuclear Information System (INIS)

    Il'inskij, A.G.; Brovko, A.P.; Zelinskaya, G.M.; Kosenko, N.S.; Khristenko, T.M.; Kobzenko, G.F.; Shkola, A.A.

    1988-01-01

    The structure of amorphous and amorphous-crystaliline Fe 40 Ni 40 B 20 and Co 70 Fe 5 Si-1 5 B 10 alloys, exposed to hydridation at different temperatures, is studied by X-ray diffraction technique. The presence of crystalline constituent in amorphous bands was determined on DRON-3 device and by method of small-angle scattering. The experimental data obtained verify, that hydridation does not only prevent the formation of crystalline phases at annealing, but leads, as well, to disappearance of band crystalline constituent in case of its presence

  16. Effect of Tm substitution on the magnetic properties and local magnetic anisotropy of amorphous Fe80-xTm xB20 ribbons

    International Nuclear Information System (INIS)

    Sayouty, E.H.; Annouar, F.; Lassri, H.; Randrianantoandro, N.; Greneche, J.M.

    2005-01-01

    We have carried out magnetic and Moessbauer studies of amorphous Fe 80-x Tm x B 20 alloys (0 ≤ x ≤ 16). With an increasing Tm content, both the Curie temperature T C and the magnetic moment of Fe atom μ Fe decrease. We have extracted the value of exchange constant A from T C and that of the local magnetic anisotropy constant K L from the coercivity. Moessbauer studies were performed in a transmission geometry and also using the conversion electron spectroscopy. Both Moessbauer spectrometry techniques show that the average hyperfine field decreases linearly with the addition of rare-earth

  17. Crystalline structure and XMCD studies of Co40Fe40B20 grown on Bi2Te3, BiTeI and Bi2Se3

    OpenAIRE

    Kaveev, A. K.; Sokolov, N. S.; Suturin, S. M.; Zhiltsov, N. S.; Golyashov, V. A.; Tereshchenko, O. E.; Prosvirin, I. P.; Kokh, K. A.; Sawada, M.

    2018-01-01

    Epitaxial films of Co40Fe40B20 (further - CoFeB) were grown on Bi2Te3(001) and Bi2Se3(001) substrates by laser molecular beam epitaxy (LMBE) technique at 200-400C. Bcc-type crystalline structure of CoFeB with (111) plane parallel to (001) plane of Bi2Te3 was observed, in contrast to polycrystalline CoFeB film formed on Bi2Se3(001) at RT using high-temperature seeding layer. Therefore, structurally ordered ferromagnetic thin films were obtained on the topological insulator surface for the firs...

  18. Lactobacillus delbrueckii UFV-H2b20 induces type 1 cytokine production by mouse cells in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    E. Neumann

    2009-04-01

    Full Text Available Lactobacillus delbrueckii UFV-H2b20 has been shown to increase clearance of bacteria injected into the blood of germ-free mice. Moreover, it induces the production of type 1 cytokines by human peripheral mononuclear cells. The objective of the present study was to investigate the production of inflammatory cytokines [interleukin-12 (IL-12 p40, tumor necrosis factor-α (TNF-α, and interferon-γ (IFN-γ] triggered in vitro by live, heat-killed or lysozyme-treated L. delbrueckii UFV-H2b20 and in vivo by a live preparation. Germ-free, L. delbrueckii-monoassociated and lipopolysaccharide (LPS-resistant C3H/HeJ mice were used as experimental models. UFV-H2b20 induced the production of IL-12 p40 and TNF-α by peritoneal cells and IFN-γ by spleen cells from germ-free or monoassociated Swiss/NIH mice and LPS-hyporesponsive mice (around 40 ng/mL for IL-12 p40, 200 pg/mL for TNF-α and 10 ng/mL for IFN-γ. Heat treatment of L. delbrueckii did not affect the production of these cytokines. Lysozyme treatment decreased IL-12 p40 production by peritoneal cells from C3H/HeJ mice, but did not affect TNF-α production by these cells or IFN-γ production by spleen cells from the same mouse strain. TNF-α production by peritoneal cells from Swiss/NIH L. delbrueckii-monoassociated mice was inhibited by lysozyme treatment. When testing IL-12 p40 and IFN-γ levels in sera from germ-free or monoassociated Swiss/NIH mice systemically challenged with Escherichia coli we observed that IL-12 p40 was produced at marginally higher levels by monoassociated mice than by germ-free mice (40 vs 60 ng/mL, but IFN-γ was produced earlier and at higher levels by monoassociated mice (monoassociated 4 and 14 ng/mL 4 and 8 h after infection, germfree 0 and 7.5 ng/mL at the same times. These results show that L. delbrueckii UFV-H2b20 stimulates the production of type 1 cytokines in vitro and in vivo, therefore suggesting that L. delbrueckii might have adjuvant properties in infection

  19. Baixas doses de misoprostol vaginal (12,5 versus 25 mcg para indução do parto a termo Low-dose vaginal misoprostol (12.5 versus 25 µg for induction of labor at term

    Directory of Open Access Journals (Sweden)

    Francisco Airton Rangel Filho

    2007-12-01

    Full Text Available OBJETIVO: comparar a efetividade de baixas doses de misoprostol vaginal (12,5 versus 25 mcg para indução do trabalho de parto. MÉTODOS: ensaio clínico controlado, randomizado, duplo-cego, realizado entre maio de 2005 e abril de 2006. Foram incluídas 62 gestantes com gravidez a termo, membranas íntegras, que necessitaram de indução do parto. Foi administrado 25 mcg (32 ou 12,5 mcg de misoprostol (30, a cada quatro horas, até, no máximo, oito doses. Estudaram-se o tipo de parto, tempo entre o início da indução e o parto, complicações perinatais e efeitos maternos adversos. As variáveis de controle foram idades materna e gestacional, paridade e índice de Bishop. Os testes estatísticos utilizados foram cálculos de médias, desvios padrão e teste t de Student (variáveis numéricas contínuas, c² (variáveis categóricas e Mann-Whitney (variáveis discretas. RESULTADOS: não houve diferença significante entre o Grupo de 12,5 e 25 mcg em relação ao intervalo de tempo entre a primeira dose e o parto (1.524 minutos versus 1.212 minutos, p=0,3, na freqüência de partos vaginais (70 versus 71,8%, p=0,7, no escore de Apgar inferior a sete ao quinto minuto (3,3 versus 6,25%, p=0,5 e na freqüência de taquissistolia (3,3 versus 6,2%, p=0,5. A média da dose total administrada de misoprostol foi significativamente maior no Grupo de 25 mcg (40 versus 61,2 mcg, p=0,03. CONCLUSÕES: misoprostol vaginal na dose de 12,5 mcg foi eficiente, com efeitos colaterais semelhante, à dose de 25 mcg de misoprostol vaginal, para indução do parto a termo.PURPOSE: to compare the effectiveness of low doses of vaginal misoprostol (12.5 versus 25 µg for induction of labor. METHODS: a double-blind, randomized, controlled clinical trial was performed in Santa Casa de Misericórdia de Sobral, from May 2005 to April 2006. Sixty-two term pregnant women, with intact membranes and with indication for labor induction, were included. They randomly received 25

  20. Monoassociation with probiotic Lactobacillus delbrueckii UFV-H2b20 stimulates the immune system and protects germfree mice against Listeria monocytogenes infection.

    Science.gov (United States)

    dos Santos, Liliane Martins; Santos, Mônica Morais; de Souza Silva, Humberto Pereira; Arantes, Rosa Maria Esteves; Nicoli, Jacques Robert; Vieira, Leda Quercia

    2011-02-01

    In the present study, we investigated the protective effects of Lactobacillus delbrueckii UFV-H2b20 on the resistance to Listeria monocytogenes infection in gnotobiotic mice. Germfree mice or monoassociated mice were infected with L. monocytogenes, and the microbiological and immunological responses were evaluated after 1, 3, and 5 days of infection. Monoassociation with L. delbrueckii was capable of protecting mice against death caused by L. monocytogenes and induced a faster clearance of the bacteria in the liver, spleen, and peritoneal cavity at days 1, 3, and 5 post-infection. Also, monoassociated mice displayed less liver injury than germfree mice. The production of TNF-α in the serum, peritoneal cavity, and gut was augmented in monoassociated mice. Likewise, the levels of IFN-γ found on supernatants of spleen cells cultures were higher after the monoassociation. In addition, increased production of nitric oxide in peritoneal cell cultures supernatants and in serum was observed in mice that received L. delbrueckii. The monoassociation with L. delbrueckii induced higher production of IL-10 in the mucosal immune system. We conclude that monoassociation with L. delbrueckii UFV-H2b20 protects mice from death caused by L. monocytogenes infection by favoring effector responses while preventing their immunopathological consequences.

  1. Identification of Lactobacillus UFV H2b20 (probiotic strain using DNA-DNA hybridization Identificação de Lactobacillus UFV H2b20 (linhagem probiótica através de hibridização DNA-DNA

    Directory of Open Access Journals (Sweden)

    J.T. de Magalhães

    2008-09-01

    Full Text Available Sequence analyses of the 16S rDNA gene and DNA-DNA hybridization tests were performed for identification of the species of the probiotic Lactobacillus UFV H2b20 strain. Using these two tests, we concluded that this strain, originally considered Lact. acidophilus, should be classified as Lact. delbrueckii.Análise da seqüência do gene 16S rDNA e ensaios de hibridização DNA_DNA foram empregados para identificar a espécie da cepa probiótica Lactobacillus UFV H2b20. Empregando-se estes dois testes, concluímos que esta cepa, originalmente considerada Lact. acidophilus, deve ser classificada como Lact. delbrueckii.

  2. Ferromagnetic resonance studies on (Co40Fe40B20)x(SiO2)1-x granular magnetic films

    International Nuclear Information System (INIS)

    Yildiz, F.; Kazan, S.; Aktas, B.; Tarapov, S.I.; Tagirov, L.; Granovsky, B.

    2006-01-01

    Magnetic properties of granular (Co 40 Fe 40 B 20 ) x (SiO 2 ) 1-x thin films (x=0.37-0.53) have been studied by ferromagnetic resonance (FMR) technique. Samples have been prepared by ion-beam deposition of Co-Fe-B particles and SiO 2 on sitall ceramic substrate. The FMR measurements have been done for different orientations of DC magnetic field with respect to the sample plane. It was found that the deduced value of effective magnetization from FMR data of the thin granular film is reduced by the volume-filling factor of the bulk saturation magnetization. The overall magnetization changes from 152 to 515G depending on the ratio of the magnetic nanoparticles in the SiO 2 matrix. From angular measurements an induced in-plane uniaxial anisotropy has been obtained due to the preparation of the film conditions as well

  3. The software design of multi-branch, multi-point remote monitoring system for temperature measurement based on MSP430 and DS18B20

    International Nuclear Information System (INIS)

    Yu Jun; Yan Yu

    2009-01-01

    This paper present that the system can acquire the remote temperature measurement data of 40 monitoring points, through the RS-232 serial port and the Intranet. System's hardware is consist of TI's MSP430F149 mixed-signal processor and UA7000A network module. Using digital temperature sensor DS18B20, the structure is simple and easy to expand, the sensors directly send out the temperature data, MSP430F149 has the advantage of ultra-low-power and high degree of integration. Using msp430F149, the multi-branch multi-point temperature measurement system is powerful, simple structure, high reliability, strong anti-interference capability. The client software is user-friendly and easy to use, it is designed in Microsoft Visual C+ +6.0 environment. The monitoring system is able to complete a total of 4 branches of the 40-point temperature measurements in real-time remote monitoring. (authors)

  4. Influence of the deposition-induced stress on the magnetic properties of magnetostrictive amorphous (Fe80Co20)80B20 multilayers with orthogonal anisotropy

    International Nuclear Information System (INIS)

    Gonzalez-Guerrero, Miguel; Prieto, Jose Luis; Sanchez, Pedro; Aroca, Claudio

    2007-01-01

    In this work, we experimentally justify that the control of the mechanical stress induced during the deposition of sputtered amorphous magnetostrictive (Fe 80 Co 20 ) 80 B 20 allows a custom design of its magnetic properties. FeCoB multilayers have been sputtered on thermal oxide Si substrates with different buffer materials. The crystalline quality and the thermomechanical properties of the buffer layer influence both the coercive and the anisotropy field. Those buffer layers with both high rigidity and poor thermal conductivity do not allow the dissipation of energy of the incoming sputtered material. Therefore, the mechanical stresses related to the deposition process cannot be released, leading to magnetic layers with high easy-axis coercive field and low anisotropy field. This shows that the mechanical stresses accumulated during deposition are a key parameter for the control of coercivity

  5. Response of metallic glasses Fe40Ni40P14B6 and Fe80B20 to irradiation with 800-MeV protons

    International Nuclear Information System (INIS)

    Cost, J.R.; Sommer, W.F.

    1981-01-01

    Metallic glasses with compositions of Fe 40 Ni 40 P 14 B 6 and Fe 80 B 20 were irradiated in the 800 MeV proton beam at the Los Alamos Meson Physics Facility while the electrical resistance and length changes were monitored. The resistance and the length of the first alloy were both found to increase and saturate with dose to ΔR/R approx. = 5 x 10 -3 and ΔL/L approx. = 2 x 10 -3 . For the second alloy the total dose of 1.1 x 10 19 p/cm 2 , which was calculated to give roughly 0.12 dpa, was slightly less than that required for saturation. No annealing of these increases was observed for anneals from room temperature to 250 0 C. These results are interpreted in terms of a model in which collision cascades create small regions of increased atomic disorder which fully overlap each other at saturation

  6. Optimization of the combustion of SOME (soybean oil methyl ester), B5, B10, B20 and petrodiesel in a semi industrial boiler

    International Nuclear Information System (INIS)

    Ghorbani, Afshin; Bazooyar, Bahamin

    2012-01-01

    This paper characterizes combustion of petrodiesel and prevalent SOME blends (B100, B5, B10 and B20), which were produced through an alkali-based transesterification in PUT, in a semi industrial boiler by determining its efficiency, exhaust emissions and costs. First, the influence of oxygen content of stock gases (by volume percent) upon regular emissions, thermal efficiency and costs (calculated by a cost function) was studied in order to investigate the performance and feasibility of using biodiesel in the boiler. In the next level, a multi-objective optimization method, named cost-based optimization, was represented and optimized the combustion of the fuels. The overall efficiency of the boiler obtained with the different fuels is comparable for the same operating points. Soy bean methyl ester and the blends emitted lower emissions than petrodiesel. Results demonstrate that the use of pure biodiesel is not economically feasible in the boiler. The total costs of the boiler obtained with the blends and petrodiesel are quite competitive. B5 is introduced to be the best fuel for using in the boiler. Results also reveal an optimum (“compromise”) in total cost of all the fuels in relation to the oxygen concentration of stock gases, which promises a cost saving in the boiler performance. -- Highlights: ► Efficiency, emissions and economy of the boiler fuelled with SOME, B5, B10, B20 and petrodiesel are investigated. ► The use of pure biodiesel was not economically feasible while economy of the blends and petrodiesel is competitive. ► B5 is introduced to be the most appropriate and economic fuel for the boiler. ► Presentation of a cost-based method optimization method. ► Introducing an optimum, “compromise”, O 2 % for the combustion of each fuel which promises a cost saving.

  7. Biostimulation of anaerobic BTEX biodegradation under fermentative methanogenic conditions at source-zone groundwater contaminated with a biodiesel blend (B20).

    Science.gov (United States)

    Ramos, Débora Toledo; da Silva, Márcio Luis Busi; Chiaranda, Helen Simone; Alvarez, Pedro J J; Corseuil, Henry Xavier

    2013-06-01

    Field experiments were conducted to assess the potential for anaerobic biostimulation to enhance BTEX biodegradation under fermentative methanogenic conditions in groundwater impacted by a biodiesel blend (B20, consisting of 20 % v/v biodiesel and 80 % v/v diesel). B20 (100 L) was released at each of two plots through an area of 1 m(2) that was excavated down to the water table, 1.6 m below ground surface. One release was biostimulated with ammonium acetate, which was added weekly through injection wells near the source zone over 15 months. The other release was not biostimulated and served as a baseline control simulating natural attenuation. Ammonium acetate addition stimulated the development of strongly anaerobic conditions, as indicated by near-saturation methane concentrations. BTEX removal began within 8 months in the biostimulated source zone, but not in the natural attenuation control, where BTEX concentrations were still increasing (due to source dissolution) 2 years after the release. Phylogenetic analysis using quantitative PCR indicated an increase in concentration and relative abundance of Archaea (Crenarchaeota and Euryarchaeota), Geobacteraceae (Geobacter and Pelobacter spp.) and sulfate-reducing bacteria (Desulfovibrio, Desulfomicrobium, Desulfuromusa, and Desulfuromonas) in the biostimulated plot relative to the control. Apparently, biostimulation fortuitously enhanced the growth of putative anaerobic BTEX degraders and associated commensal microorganisms that consume acetate and H2, and enhance the thermodynamic feasibility of BTEX fermentation. This is the first field study to suggest that anaerobic-methanogenic biostimulation could enhance source zone bioremediation of groundwater aquifers impacted by biodiesel blends.

  8. Assessment of microbial communities associated with fermentative-methanogenic biodegradation of aromatic hydrocarbons in groundwater contaminated with a biodiesel blend (B20).

    Science.gov (United States)

    Ramos, Débora Toledo; da Silva, Márcio Luís Busi; Nossa, Carlos Wolfgang; Alvarez, Pedro J J; Corseuil, Henry Xavier

    2014-09-01

    A controlled field experiment was conducted to assess the potential for fermentative-methanogenic biostimulation (by ammonium-acetate injection) to enhance biodegradation of benzene, toluene, ethylbenzene and xylenes (BTEX) as well as polycyclic aromatic hydrocarbons (PAHs) in groundwater contaminated with biodiesel B20 (20:80 v/v soybean biodiesel and diesel). Changes in microbial community structure were assessed by pyrosequencing 16S rRNA analyses. BTEX and PAH removal began 0.7 year following the release, concomitantly with the increase in the relative abundance of Desulfitobacterium and Geobacter spp. (from 5 to 52.7 % and 15.8 to 37.3 % of total Bacteria 16S rRNA, respectively), which are known to anaerobically degrade hydrocarbons. The accumulation of anaerobic metabolites acetate and hydrogen that could hinder the thermodynamic feasibility of BTEX and PAH biotransformations under fermentative/methanogenic conditions was apparently alleviated by the growing predominance of Methanosarcina. This suggests the importance of microbial population shifts that enrich microorganisms capable of interacting syntrophically to enhance the feasibility of fermentative-methanogenic bioremediation of biodiesel blend releases.

  9. Studying nearest neighbor correlations by atom probe tomography (APT) in metallic glasses as exemplified for Fe40Ni40B20 glassy ribbons

    KAUST Repository

    Shariq, Ahmed

    2012-01-01

    A next nearest neighbor evaluation procedure of atom probe tomography data provides distributions of the distances between atoms. The width of these distributions for metallic glasses studied so far is a few Angstrom reflecting the spatial resolution of the analytical technique. However, fitting Gaussian distributions to the distribution of atomic distances yields average distances with statistical uncertainties of 2 to 3 hundredth of an Angstrom. Fe 40Ni40B20 metallic glass ribbons are characterized this way in the as quenched state and for a state heat treated at 350 °C for 1 h revealing a change in the structure on the sub-nanometer scale. By applying the statistical tool of the χ2 test a slight deviation from a random distribution of B-atoms in the as quenched sample is perceived, whereas a pronounced elemental inhomogeneity of boron is detected for the annealed state. In addition, the distance distribution of the first fifteen atomic neighbors is determined by using this algorithm for both annealed and as quenched states. The next neighbor evaluation algorithm evinces a steric periodicity of the atoms when the next neighbor distances are normalized by the first next neighbor distance. A comparison of the nearest neighbor atomic distribution for as quenched and annealed state shows accumulation of Ni and B. Moreover, it also reveals the tendency of Fe and B to move slightly away from each other, an incipient step to Ni rich boride formation. © 2011 Elsevier B.V.

  10. Helical magnetic structure and the anomalous and topological Hall effects in epitaxial B20 Fe1 -yCoyGe films

    Science.gov (United States)

    Spencer, Charles S.; Gayles, Jacob; Porter, Nicholas A.; Sugimoto, Satoshi; Aslam, Zabeada; Kinane, Christian J.; Charlton, Timothy R.; Freimuth, Frank; Chadov, Stanislav; Langridge, Sean; Sinova, Jairo; Felser, Claudia; Blügel, Stefan; Mokrousov, Yuriy; Marrows, Christopher H.

    2018-06-01

    Epitaxial films of the B20-structure compound Fe1 -yCoyGe were grown by molecular beam epitaxy on Si (111) substrates. The magnetization varied smoothly from the bulklike values of one Bohr magneton per Fe atom for FeGe to zero for nonmagnetic CoGe. The chiral lattice structure leads to a Dzyaloshinskii-Moriya interaction (DMI), and the films' helical magnetic ground state was confirmed using polarized neutron reflectometry measurements. The pitch of the spin helix, measured by this method, varies with Co content y and diverges at y ˜0.45 . This indicates a zero crossing of the DMI, which we reproduced in calculations using first-principles methods. We also measured the longitudinal and Hall resistivity of our films as a function of magnetic field, temperature, and Co content y . The Hall resistivity is expected to contain contributions from the ordinary, anomalous, and topological Hall effects. Both the anomalous and topological Hall resistivities show peaks around y ˜0.5 . Our first-principles calculations show a peak in the topological Hall constant at this value of y , related to the strong spin polarization predicted for intermediate values of y . Our calculations predict half-metallicity for y =0.6 , consistent with the experimentally observed linear magnetoresistance at this composition, and potentially related to the other unusual transport properties for intermediate value of y . While it is possible to reconcile theory with experiment for the various Hall effects for FeGe, the large topological Hall resistivities for y ˜0.5 are much larger than expected when the very small emergent fields associated with the divergence in the DMI are taken into account.

  11. Giant Spin Hall Effect and Switching Induced by Spin-Transfer Torque in a W /Co40Fe40B20/MgO Structure with Perpendicular Magnetic Anisotropy

    Science.gov (United States)

    Hao, Qiang; Xiao, Gang

    2015-03-01

    We obtain robust perpendicular magnetic anisotropy in a β -W /Co40Fe40B20/MgO structure without the need of any insertion layer between W and Co40Fe40B20 . This is achieved within a broad range of W thicknesses (3.0-9.0 nm), using a simple fabrication technique. We determine the spin Hall angle (0.40) and spin-diffusion length for the bulk β form of tungsten with a large spin-orbit coupling. As a result of the giant spin Hall effect in β -W and careful magnetic annealing, we significantly reduce the critical current density for the spin-transfer-torque-induced magnetic switching in Co40Fe40B20 . The elemental β -W is a superior candidate for magnetic memory and spin-logic applications.

  12. Comparison of the prognostic and predictive utilities of the 21-gene Recurrence Score assay and Adjuvant! for women with node-negative, ER-positive breast cancer: results from NSABP B-14 and NSABP B-20.

    Science.gov (United States)

    Tang, Gong; Shak, Steven; Paik, Soonmyung; Anderson, Stewart J; Costantino, Joseph P; Geyer, Charles E; Mamounas, Eleftherios P; Wickerham, D Lawrence; Wolmark, Norman

    2011-05-01

    The Oncotype DX Recurrence Score (RS) is a validated genomic predictor of outcome and response to adjuvant chemotherapy in ER-positive breast cancer. Adjuvant! was developed using SEER registry data and results from the Early Breast Cancer Clinical Trialists' overview analyses to estimate outcome and benefit from adjuvant hormonal therapy and chemotherapy. In this report we compare the prognostic and predictive utility of these two tools in node-negative, ER-positive breast cancer. RS and Adjuvant! results were available from 668 tamoxifen-treated NSABP B-14 patients, 227 tamoxifen-treated NSABP B-20 patients, and 424 chemotherapy plus tamoxifen-treated B-20 patients. Adjuvant! results were also available from 1952 B-20 patients. The primary endpoint was distant recurrence-free interval (DRFI). Cox proportional hazards models were used to compare the prognostic and predictive utility of RS and Adjuvant!. Both RS (P < 0.001) and Adjuvant! (P = 0.002) provided strong independent prognostic information in tamoxifen-treated patients. Combining RS and individual clinicopathologic characteristics provided greater prognostic discrimination than combining RS and the composite Adjuvant!. In the B-20 cohort with RS results (n = 651), RS was significantly predictive of chemotherapy benefit (interaction P = 0.031 for DRFI, P = 0.011 for overall survival [OS], P = 0.082 for disease-free survival [DFS]), but Adjuvant! was not (interaction P = 0.99, P = 0.311, and P = 0.357, respectively). However, in the larger B-20 sub-cohort (n = 1952), Adjuvant! was significantly predictive of chemotherapy benefit for OS (interaction P = 0.009) but not for DRFI (P = 0.219) or DFS (P = 0.099). Prognostic estimates can be optimized by combining RS and clinicopathologic information instead of simply combining RS and Adjuvant!. RS should be used for estimating relative chemotherapy benefit.

  13. Association Between the 21-Gene Recurrence Score Assay and Risk of Locoregional Recurrence in Node-Negative, Estrogen Receptor–Positive Breast Cancer: Results From NSABP B-14 and NSABP B-20

    Science.gov (United States)

    Mamounas, Eleftherios P.; Tang, Gong; Fisher, Bernard; Paik, Soonmyung; Shak, Steven; Costantino, Joseph P.; Watson, Drew; Geyer, Charles E.; Wickerham, D. Lawrence; Wolmark, Norman

    2010-01-01

    Purpose The 21-gene OncotypeDX recurrence score (RS) assay quantifies the risk of distant recurrence in tamoxifen-treated patients with node-negative, estrogen receptor (ER)–positive breast cancer. We investigated the association between RS and risk for locoregional recurrence (LRR) in patients with node-negative, ER-positive breast cancer from two National Surgical Adjuvant Breast and Bowel Project (NSABP) trials (NSABP B-14 and B-20). Patients and Methods RS was available for 895 tamoxifen-treated patients (from both trials), 355 placebo-treated patients (from B-14), and 424 chemotherapy plus tamoxifen-treated patients (from B-20). The primary end point was time to first LRR. Distant metastases, second primary cancers, and deaths before LRR were censored. Results In tamoxifen-treated patients, LRR was significantly associated with RS risk groups (P 30). There were also significant associations between RS and LRR in placebo-treated patients from B-14 (P = .022) and in chemotherapy plus tamoxifen–treated patients from B-20 (P = .028). In multivariate analysis, RS was an independent significant predictor of LRR along with age and type of initial treatment. Conclusion Similar to the association between RS and risk for distant recurrence, a significant association exists between RS and risk for LRR. This information has biologic consequences and potential clinical implications relative to locoregional therapy decisions for patients with node-negative and ER-positive breast cancer. PMID:20065188

  14. Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20.

    Science.gov (United States)

    Mamounas, Eleftherios P; Tang, Gong; Fisher, Bernard; Paik, Soonmyung; Shak, Steven; Costantino, Joseph P; Watson, Drew; Geyer, Charles E; Wickerham, D Lawrence; Wolmark, Norman

    2010-04-01

    The 21-gene OncotypeDX recurrence score (RS) assay quantifies the risk of distant recurrence in tamoxifen-treated patients with node-negative, estrogen receptor (ER)-positive breast cancer. We investigated the association between RS and risk for locoregional recurrence (LRR) in patients with node-negative, ER-positive breast cancer from two National Surgical Adjuvant Breast and Bowel Project (NSABP) trials (NSABP B-14 and B-20). RS was available for 895 tamoxifen-treated patients (from both trials), 355 placebo-treated patients (from B-14), and 424 chemotherapy plus tamoxifen-treated patients (from B-20). The primary end point was time to first LRR. Distant metastases, second primary cancers, and deaths before LRR were censored. In tamoxifen-treated patients, LRR was significantly associated with RS risk groups (P 30). There were also significant associations between RS and LRR in placebo-treated patients from B-14 (P = .022) and in chemotherapy plus tamoxifen-treated patients from B-20 (P = .028). In multivariate analysis, RS was an independent significant predictor of LRR along with age and type of initial treatment. Similar to the association between RS and risk for distant recurrence, a significant association exists between RS and risk for LRR. This information has biologic consequences and potential clinical implications relative to locoregional therapy decisions for patients with node-negative and ER-positive breast cancer.

  15. No adverse lung effects of 7- and 28-day inhalation exposure of rats to emissions from petrodiesel fuel containing 20% rapeseed methyl esters (B20) with and without particulate filter - the FuelHealth project.

    Science.gov (United States)

    Magnusson, Pål; Oczkowski, Michał; Øvrevik, Johan; Gajewska, Malgorzata; Wilczak, Jacek; Biedrzycki, Jacek; Dziendzikowska, Katarzyna; Kamola, Dariusz; Królikowski, Tomasz; Kruszewski, Marcin; Lankoff, Anna; Mruk, Remigiusz; Brunborg, Gunnar; Instanes, Christine; Gromadzka-Ostrowska, Joanna; Myhre, Oddvar

    2017-04-01

    Increased use of biofuels raises concerns about health effects of new emissions. We analyzed relative lung health effects, on Fisher 344 rats, of diesel engine exhausts emissions (DEE) from a Euro 5-classified diesel engine running on petrodiesel fuel containing 20% rapeseed methyl esters (B20) with and without diesel particulate filter (DPF). One group of animals was exposed to DEE for 7 days (6 h/day), and another group for 28 days (6 h/day, 5 days/week), both with and without DPF. The animals (n = 7/treatment) were exposed in whole body exposure chambers. Animals breathing clean air were used as controls. Genotoxic effects of the lungs by the Comet assay, histological examination of lung tissue, bronchoalveolar lavage fluid (BALF) markers of pulmonary injury, and mRNA markers of inflammation and oxidative stress were analyzed. Our results showed that a minor number of genes related to inflammation were slightly differently expressed in the exposed animals compared to control. Histological analysis also revealed only minor effects on inflammatory tissue markers in the lungs, and this was supported by flow cytometry and ELISA analysis of cytokines in BALF. No exposure-related indications of genotoxicity were observed. Overall, exposure to DEE with or without DPF technology produced no adverse effects in the endpoints analyzed in the rat lung tissue or the BALF. Overall, exposure to DEE from a modern Euro 5 light vehicle engine run on B20 fuel with or without DPF technology produced no adverse effects in the endpoints analyzed in the rat lung tissue or the BALF.

  16. Electric-Field Control of Magnetism in Co40Fe40B20/(1-x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 Multiferroic Heterostructures with Different Ferroelectric Phases.

    Science.gov (United States)

    Liu, Yan; Zhao, Yonggang; Li, Peisen; Zhang, Sen; Li, Dalai; Wu, Hao; Chen, Aitian; Xu, Yang; Han, X F; Li, Shiyan; Lin, Di; Luo, Haosu

    2016-02-17

    Electric-field control of magnetism in multiferroic heterostructures composed of Co40Fe40B20 (CoFeB) and (1-x)Pb(Mg1/3Nb2/3)O3-xPbTiO3 (PMN-xPT) with different ferroelectric phases via changing composition and temperature is explored. It is demonstrated that the nonvolatile looplike bipolar-electric-field-controlled magnetization, previously found in the CoFeB/PMN-xPT heterostructures with PMN-xPT in the rhombohedral (R) phase around the morphotropic phase boundary (MPB), also occurs for PMN-xPTs with both R phase (far away from MPB) and monoclinic (M) phase, suggesting that the phenomenon is the common feature of CoFeB/PMN-xPT multiferroic heterostructures for PMN-xPT with different phases. The magnitude of the effect changes with increasing temperature and volatile bipolar-electric-field-controlled magnetization with a butterflylike behavior occurs when the ferroelectric phase changes to the tetragonal phase (T). Moreover, for the R-phase sample with x = 0.18, an abrupt and giant increase of magnetization is observed at a characteristic temperature in the temperature dependence of magnetization curve. These results are discussed in terms of coupling between magnetism and ferroelectric domains including macro- and microdomains for different ferroelectric phases. This work is helpful for understanding the phenomena of electric-field control of magnetism in FM/FE multiferroic heterostructures and is also important for applications.

  17. Perpendicular magnetic anisotropy in Ta|Co40Fe40B20|MgAl2O4 structures and perpendicular CoFeB|MgAl2O4|CoFeB magnetic tunnel junction

    KAUST Repository

    Tao, B. S.

    2014-09-08

    Magnetic properties of Co40Fe40B20(CoFeB) thin films sandwiched between Ta and MgAl2O4layers have been systematically studied. For as-grown state, Ta/CoFeB/MgAl2O4structures exhibit good perpendicular magnetic anisotropy (PMA) with interface anisotropy Ki=1.22erg/cm2, which further increases to 1.30erg/cm2after annealing, while MgAl2O4/CoFeB/Ta multilayer shows in-plane magnetic anisotropy and must be annealed in order to achieve PMA. For bottom CoFeB layer, the thickness window for PMA is from 0.6 to 1.0nm, while that for top CoFeB layer is between 0.8 and 1.4nm. Perpendicular magnetic tunnel junctions (p-MTJs) with a core structure of CoFeB/MgAl2O4/CoFeB have also been fabricated and tunneling magnetoresistance ratio of about 36% at room temperature and 63% at low temperature have been obtained. The intrinsic excitations in the p-MTJs have been identified by inelastic electron-tunneling spectroscopy.

  18. Perpendicular magnetic anisotropy in Ta|Co40Fe40B20|MgAl2O4 structures and perpendicular CoFeB|MgAl2O4|CoFeB magnetic tunnel junction

    KAUST Repository

    Tao, B. S.; Li, D. L.; Yuan, Z. H.; Liu, H. F.; Ali, S. S.; Feng, J. F.; Wei, H. X.; Han, X. F.; Liu, Y.; Zhao, Y. G.; Zhang, Q.; Guo, Zaibing; Zhang, Xixiang

    2014-01-01

    Magnetic properties of Co40Fe40B20(CoFeB) thin films sandwiched between Ta and MgAl2O4layers have been systematically studied. For as-grown state, Ta/CoFeB/MgAl2O4structures exhibit good perpendicular magnetic anisotropy (PMA) with interface anisotropy Ki=1.22erg/cm2, which further increases to 1.30erg/cm2after annealing, while MgAl2O4/CoFeB/Ta multilayer shows in-plane magnetic anisotropy and must be annealed in order to achieve PMA. For bottom CoFeB layer, the thickness window for PMA is from 0.6 to 1.0nm, while that for top CoFeB layer is between 0.8 and 1.4nm. Perpendicular magnetic tunnel junctions (p-MTJs) with a core structure of CoFeB/MgAl2O4/CoFeB have also been fabricated and tunneling magnetoresistance ratio of about 36% at room temperature and 63% at low temperature have been obtained. The intrinsic excitations in the p-MTJs have been identified by inelastic electron-tunneling spectroscopy.

  19. 15 CFR 8b.20 - Admission and recruitment.

    Science.gov (United States)

    2010-01-01

    ... predictor of success in the education program or activity in question; and (ii) Alternate tests or criteria... exception. When a recipient is taking remedial action to correct the effects of past discrimination pursuant... first year grades, but shall conduct periodic validity studies against the criterion of overall success...

  20. Biomagnetic Measurement System on Mice-Evaluation of System Performance by MCG and Application to MEG

    International Nuclear Information System (INIS)

    Nakamura, T; Shirai, K; Ono, Y; Kasai, N; Odawara, A; Ishiyama, A

    2006-01-01

    We developed a biomagnetic measurement system on mice. Our initial model of the system has the magnetic field sensitivity of 1.3 pT/Hz 1/2 in the white-noise region (10 Hz-10 kHz). And using the system, we succeeded to obtain magnetically the heart activity on mice. However, in its application to measure the brain activity on mice, it was necessary to improve the magnetic field sensitivity of the system. Therefore, we changed the material of the window cap, which holds a sapphire glass window on the dewar tail, to ceramic. The system noise was decreased and the magnetic field sensitivity of the system was improved to 0.75 pT/Hz 1/2 in the white-noise region. For an initial measurement of the brain activity, we also developed a whisker stimulation system using a piezoelectric element to evoke somatosensory responses

  1. A REVERBERATION-BASED BLACK HOLE MASS FOR MCG-06-30-15

    International Nuclear Information System (INIS)

    Bentz, Misty C.; Crenshaw, D. Michael; Ou-Yang, Benjamin; Cackett, Edward M.; Horne, Keith; Street, Rachel

    2016-01-01

    We present the results of a reverberation campaign targeting MGC-06-30-15. Spectrophotometric monitoring and broad-band photometric monitoring over the course of four months in spring 2012 allowed a determination of a time delay in the broad H β emission line of τ = 5.3 ± 1.8 days in the rest frame of the active galactic nucleus (AGN). Combined with the width of the variable portion of the emission line, we determine a black hole mass of M BH = (1.6 ± 0.4) × 10 6 M ⊙ . Both the H β time delay and the black hole mass are in good agreement with expectations from the R BLR – L and M BH – σ ⋆ relationships for other reverberation-mapped AGNs. The H β time delay is also in good agreement with the relationship between H β and broad-band near-IR delays, in which the effective size of the broad-line region is ∼4–5 times smaller than the inner edge of the dust torus. Additionally, the reverberation-based mass is in good agreement with estimates from the scaling relationship of the break in the X-ray power spectral density, and with constraints based on stellar kinematics derived from integral field spectroscopy of the inner ∼0.5 kpc of the galaxy.

  2. A REVERBERATION-BASED BLACK HOLE MASS FOR MCG-06-30-15

    Energy Technology Data Exchange (ETDEWEB)

    Bentz, Misty C.; Crenshaw, D. Michael; Ou-Yang, Benjamin [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30303 (United States); Cackett, Edward M. [Department of Physics and Astronomy, Wayne State University, 666 W. Hancock St., Detroit, MI 48201 (United States); Horne, Keith [SUPA Physics and Astronomy, University of St. Andrews, Fife KY16 9SS (United Kingdom); Street, Rachel, E-mail: bentz@astro.gsu.edu [Las Cumbres Observatory Global Telescope Network, 6740B Cortona Drive, Goleta, CA 93117 (United States)

    2016-10-20

    We present the results of a reverberation campaign targeting MGC-06-30-15. Spectrophotometric monitoring and broad-band photometric monitoring over the course of four months in spring 2012 allowed a determination of a time delay in the broad H β emission line of τ = 5.3 ± 1.8 days in the rest frame of the active galactic nucleus (AGN). Combined with the width of the variable portion of the emission line, we determine a black hole mass of M {sub BH} = (1.6 ± 0.4) × 10{sup 6} M {sub ⊙}. Both the H β time delay and the black hole mass are in good agreement with expectations from the R {sub BLR}– L and M {sub BH}– σ {sub ⋆} relationships for other reverberation-mapped AGNs. The H β time delay is also in good agreement with the relationship between H β and broad-band near-IR delays, in which the effective size of the broad-line region is ∼4–5 times smaller than the inner edge of the dust torus. Additionally, the reverberation-based mass is in good agreement with estimates from the scaling relationship of the break in the X-ray power spectral density, and with constraints based on stellar kinematics derived from integral field spectroscopy of the inner ∼0.5 kpc of the galaxy.

  3. effectiveness and safety of 2-hourly 20 mcg oral misoprostol solution

    African Journals Online (AJOL)

    2014-09-01

    Sep 1, 2014 ... misoprostol were augmented with oxytocin and delivered vaginally. The Caesarean .... who accepted to participate were recruited and signed the informed ... the research assistant mid wife then picked a sealed opaque ...

  4. Superconducting spin valves controlled by spiral re-orientation in B20-family magnets

    Science.gov (United States)

    Pugach, N. G.; Safonchik, M.; Champel, T.; Zhitomirsky, M. E.; Lähderanta, E.; Eschrig, M.; Lacroix, C.

    2017-10-01

    We propose a superconducting spin-triplet valve, which consists of a superconductor and an itinerant magnetic material, with the magnet showing an intrinsic non-collinear order characterized by a wave vector that may be aligned in a few equivalent preferred directions under the control of a weak external magnetic field. Re-orienting the spiral direction allows one to controllably modify long-range spin-triplet superconducting correlations, leading to spin-valve switching behavior. Our results indicate that the spin-valve effect may be noticeable. This bilayer may be used as a magnetic memory element for cryogenic nanoelectronics. It has the following advantages in comparison to superconducting spin valves proposed previously: (i) it contains only one magnetic layer, which may be more easily fabricated and controlled; (ii) its ground states are separated by a potential barrier, which solves the "half-select" problem of the addressed switch of memory elements.

  5. Permeation of gasoline, diesel, bioethanol (E85), and biodiesel (B20) fuels through six glove materials.

    Science.gov (United States)

    Chin, Jo-Yu; Batterman, Stuart A

    2010-07-01

    Biofuels and conventional fuels differ in terms of their evaporation rates, permeation rates, and exhaust emissions, which can alter exposures of workers, especially those in the fuel refining and distribution industries. This study investigated the permeation of biofuels (bioethanol 85%, biodiesel 20%) and conventional petroleum fuels (gasoline and diesel) through gloves used in occupational settings (neoprene, nitrile, and Viton) and laboratories (latex, nitrile, and vinyl), as well as a standard reference material (neoprene sheet). Permeation rates and breakthrough times were measured using the American Society for Testing and Materials F739-99 protocol, and fuel and permeant compositions were measured by gas chromatography/mass spectrometry. In addition, we estimated exposures for three occupational scenarios and recommend chemical protective clothing suitable for use with motor fuels. Permeation rates and breakthrough times depended on the fuel-glove combination. Gasoline had the highest permeation rate among the four fuels. Bioethanol (85%) had breakthrough times that were two to three times longer than gasoline through neoprene, nitrile Sol-Vex, and the standard reference materials. Breakthrough times for biodiesel (20%) were slightly shorter than for diesel for the latex, vinyl, nitrile examination, and the standard neoprene materials. The composition of permeants differed from neat fuels, e.g., permeants were significantly enriched in the lighter aromatics including benzene. Viton was the best choice among the tested materials for the four fuels tested. Among the scenarios, fuel truck drivers had the highest uptake via inhalation based on the personal measurements available in the literature, and gasoline station attendants had highest uptake via dermal exposure if gloves were not worn. Appropriate selection and use of gloves can protect workers from dermal exposures; however, current recommendations from the National Institute for Occupational Safety and Health should be revised to account for contemporary fuel formulations that routinely contain ethanol.

  6. Evolution of optically selected quasars with z<2.2 and B<20

    International Nuclear Information System (INIS)

    Marshall, H.L.

    1985-01-01

    Several complete samples of optically selected quasars are combined to give details of the quasar luminosity function and its evolution for redshifts less than 2.2. Sufficient coverage of the Hubble diagram is obtained that luminosity-dependent density evolution models can be tested and compared against pure luminosity evolution models. Although luminosity-dependent evolution is indicated if the evolution function has an exponential form, the data are consistent with a power-law evolution model that is independent of luminosity. When the sample is split into halves by redshift, a better fit is obtained with a power-law evolution model than with an exponential model. Furthermore, the luminosity function is consistent with a power-law shape whose slope is independent of redshift. Pure luminosity evolution models wherein luminosities evolve as (1+z)/sup 3.5/ and the luminosity functioin is given by dN/dLproportionalL/sup -3.6/ are consistent with these results and fit the data very well. These results suggest that the same mass supply and energy generation mechanisms apply over several decades of optical luminosity and for z<2.2

  7. Crystallization of amorphous pseudobinary alloys of the type (Fe1-x Nix)80 B20

    International Nuclear Information System (INIS)

    Vasconcellos, M.A.Z.; Baibich, M.N.

    1984-01-01

    It was studied the crystallization of amorphous metallic ribbons of Fe 1-x Ni x 80 B 2 0 using the method of isochronous heating at variable slopes. The crystallization temperatures were determined from the transition observed in the electrical resistivity. (M.W.O.) [pt

  8. A long look at MCG-5-23-16 with NuSTAR. I. relativistic reflection and coronal properties

    DEFF Research Database (Denmark)

    Zoghbi, Abderahmen; Matt, G; Miller, J. M.

    2017-01-01

    between the cutoff energy and both the hard X-ray flux and spectral index. The measurements imply that the coronal plasma is not at the runaway electron-positron pair limit, and instead contains mostly electrons. The observed variability in the coronal properties is driven by a variable optical depth...

  9. Modeling time delays in the X-ray spectrum of the Seyfert galaxy MCG-6-30-15

    Czech Academy of Sciences Publication Activity Database

    Goosmann, René; Czerny, B.; Karas, Vladimír; Ponti, G.

    2007-01-01

    Roč. 466, č. 3 (2007), s. 865-873 ISSN 0004-6361 R&D Projects: GA MŠk(CZ) LC06014; GA AV ČR IAA300030510 Grant - others:GAUK(CZ) GAUK 299/2004; EU(XE) ESA-PECS project No. 98040 Institutional research plan: CEZ:AV0Z10030501 Source of funding: V - iné verejné zdroje Keywords : accretion disks * galaxie s: Seyfert * active galaxie s * radiative transfer Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.259, year: 2007

  10. Correlated spin glass generated by structural disorder in the amorphous Dy6Fe74B20 alloy

    Science.gov (United States)

    Tejada, J.; Martinez, B.; Labarta, A.; Chudnovsky, E. M.

    1991-10-01

    Magnetic properties of the amorphous Dy-Fe-B alloy are studied in terms of the correlated-spin-glass approach of Chudnovsky et al.$-- Features predicted by the theory are clearly observed in the experiment. It is shown that the magnetization law may be presented in the form where it is determined by the dimensionless correlation function of structural disorder, C(y), only. The analysis of the magnetization curve allows one to distinguish between different models of disorder in amorphous solids. Experimental data on Dy-Fe-B are in favor of C=exp(-1/2y2).

  11. Correlated spin glass generated by structural disorder in the amorphous Dy6Fe74B20 alloy

    International Nuclear Information System (INIS)

    Tejada, J.; Martinez, B.; Labarta, A.; Chudnovsky, E.M.

    1991-01-01

    Magnetic properties of the amorphous Dy-Fe-B alloy are studied in terms of the correlated-spin-glass approach of Chudnovsky et al.$---- Features predicted by the theory are clearly observed in the experiment. It is shown that the magnetization law may be presented in the form where it is determined by the dimensionless correlation function of structural disorder, C(y), only. The analysis of the magnetization curve allows one to distinguish between different models of disorder in amorphous solids. Experimental data on Dy-Fe-B are in favor of C=exp(-1/2y 2 )

  12. Pembuatan Alat Bantu Stress Detector Menggunakan Sensor Hir333, GSR, dan DS18B20 Berbasis Mikrokontroler ATMega 8

    OpenAIRE

    Sembiring, Ivo Zoel

    2017-01-01

    Has designed a detector stress in humans with the physiological parameters of stress. Stress is a common respons to their demand on the body. The suit is the necessity to adjust, and it causes th body’s equilibrium disturbed. Present, stress is not only experienced inthose who are younger. Stress also affects the condition of the body. If the people stress, the body will hold an integrated reaction against stressors. These reactios include increased heart rate, fast breathing, ...

  13. U.S. Army and Department of Defense Experience with the Use of B20 and other Biodiesel Blends

    Science.gov (United States)

    2014-05-01

    cleaning rate were substantially increased. Note: MGO procured for the US military (USN, USCG, MSC, etc) meets the ISO 8217 Grade DMA specification...21000 3.48 6/6/2012 15005 3.01 8/22/2012 20750 2.75 9/8/2012 27000 0.27 9/26/2012 26000 0.27 10/18/2012 24500 2.31 1. Excessive fuel filter

  14. High occurrence of Bathyarchaeota (MCG) in the deep-sea sediments of South China Sea quantified using newly designed PCR primers.

    Science.gov (United States)

    Yu, Tiantian; Liang, Qianyong; Niu, Mingyang; Wang, Fengping

    2017-08-01

    The archaeal phylum Bathyarchaeota, which is composed of a large number of diverse lineages, is widespread and abundant in marine sediments. Environmental factors that control the distribution, abundance and evolution of this largely diversified archaeal phylum are currently unclear. In this study, a new pair of specific primers that target the major marine subgroups of bathyarchaeotal 16S rRNA genes was designed and evaluated to investigate the distribution and abundance of Bathyarchaeota in marine sediments. The abundance of Bathyarchaeota along two sediment cores from the deep-sea sediments of South China Sea (SCS, each from the Dongsha and Shenhu area) was determined. A strong correlation was found between the bathyarchaeotal abundance and the content of total organic carbon (TOC), suggesting an important role of Bathyarchaeota in organic matter remineralisation in the sediments of SCS. Furthermore, diversity analysis revealed that subgroups Bathy-2, Bathy-8 and Bathy-10 were dominant bathyarchaeotal members of the deep-sea sediments in the SCS. Bathy-8 was found predominantly within the reducing and deeper sediment layers, while Bathy-10 occurred preferentially in the oxidizing and shallower sediment layers. Our study lays a foundation for the further understanding of the ecological functions and niche differentiation of the important but not well-understood sedimentary archaeal group. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

  15. Documentation for the machine-readable version of the Morphological Catalogue of Galaxies (MCG) of Vorontsov-Velyaminov et al, 1962-1968

    Science.gov (United States)

    Warren, W. H., Jr.

    1982-01-01

    Modifications, corrections, and the record format are provided for the machine-readable version of the "Morphological Catalogue of Galaxies.' In addition to hundreds of individual corrections, a detailed comparison of the machine-readable with the published catalogue resulted in the addition of 116 missing objects, the deletion of 10 duplicate records, and a format modification to increase storage efficiency.

  16. X-ray polarimetry as a new tool to discriminate reflection from absorption scenarios - predictions for MCG-6-30-15

    Czech Academy of Sciences Publication Activity Database

    Marin, F.; Goosmann, R. W.; Dovčiak, Michal; Muleri, F.; Porquet, D.; Grosso, N.; Karas, Vladimír; Matt, G.

    2012-01-01

    Roč. 426, č. 1 (2012), L101-L105 ISSN 0035-8711 R&D Projects: GA MŠk LD12010 Institutional support: RVO:67985815 Keywords : black holes * accretion disks Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics; BN - Astronomy, Celestial Mechanics, Astrophysics (ASU-R) Impact factor: 5.521, year: 2012

  17. Disminución de Demanda en Horario Punta (Peak Shaving) Mediante el Uso de un Generador en Sitio, Utilizando Diesel y Biodiesel B20

    OpenAIRE

    Orozco Cuevas, Humberto

    2005-01-01

    En la actualidad, la energía eléctrica es un servicio del cuál muy difícilmente podemos prescindir, nos hemos acostumbrado a depender de ella de tal manera que en el momento que no la tenemos se vuelve un problema el realizar nuestras actividades más elementales. Imaginemos por un momento que sÚbitamente una ciudad se queda sin energía eléctrica: los semáforos inoperantes generarían un caos vial, las oficinas sin aire acondicionado y computadoras serían insoportables, las industrias no podría...

  18. Analysis of a combustion, performance and emission characteristics of a CNG-B20 fuelled diesel engine under dual fuel mode

    Directory of Open Access Journals (Sweden)

    Pankaj S. Shelke

    2016-09-01

    Full Text Available The Carbon dioxide (CO2 is one of the primary greenhouse gases emitted by various human activities. CO2 is naturally present in the atmosphere as part of carbon cycle. Human activities are altering the carbon cycle by adding or removing CO2 to the atmosphere. The main human activity that emits the CO2 is combustion of fossil fuels for energy and transportation. Compression ignition (CI engines emit high amount of CO2 emission as it is the end product of complete combustion of hydro carbon fuels. Moreover, they emit higher NOx (nitrogen oxides and PM (particulate matter emissions and have higher fuel consumption. In the present study, experimental investigations were carried out on a CI engine under dual fuel mode with biodiesel as a pilot fuel and compressed natural gas (CNG as a main fuel. The effects of 10 % and 20 % CNG energy shares on performance and emission characteristics of the engine at rated (100% loads were studied. Experimental results indicate the beneficial of CNG addition on improvement in the engine efficiency, and reduction in NOx and CO2 emissions. The NOx and CO2 emissions decreased by 14.24 % and 30 % respectively at the rated load with biodiesel + CNG (20 % energy share as compared to base diesel. No knocking combustion was observed during the tests which confirm the smooth operation. The dual fuel operation with combination of CNG-biodiesel is an effective method to reduce NOx and CO2 emissions with an additional benefit of lower specific energy consumption.

  19. Effect of manufacturing method on the magnetic properties and formation of structural defects in Fe61Co10Y8Zr1B20 amorphous alloy

    International Nuclear Information System (INIS)

    Nabialek, M.G.; Pietrusiewicz, P.; Dospial, M.J.; Szota, M.; Błoch, K.; Gruszka, K.; Oźga, K.; Garus, S.

    2014-01-01

    Highlights: • Influence of manufacturing method on structural defects was studied. • Samples were obtained by the use of injection-casting and melt-spinning techniques. • The defects have been indirectly analyzed by approach to ferromagnetic saturation. • Prolonged solidification time allows recombination of atoms arrangement in a volume. • That reduce internal stress and leads to increase in the packing density of atoms. - Abstract: Soft magnetic properties of amorphous alloys are determined by their structure, which strongly depends on their manufacturing method. Alloys obtained in the form of conventional amorphous alloys (tapes) are cooled with a much higher rate than the material obtained in the form of tiles by the injection casting method. The cooling rate and production method determines the type and number of structural defects created in the volume of produced samples. The paper presents an indirect method for the analysis of structural defects and their effect on the magnetic properties of studied alloys. Basing on initial magnetization curve analysis in the area of so-called approach to ferromagnetic saturation was found that point defects were forming in the samples in the form of tapes. The magnetization process of tiles were influenced by the presence of conglomerates of point defects called quasidislocation dipoles

  20. Multicenter study on the immunogenicity and safety of two recombinant vaccines against hepatitis B

    Directory of Open Access Journals (Sweden)

    Reinaldo Menezes Martins

    2004-12-01

    Full Text Available The immunogenicity and safety of a new recombinant hepatitis B vaccine from the Instituto Butantan (Butang® were evaluated in a multicenter, double-blind, prospective equivalence study in three centers in Brazil. Engerix B® was the standard vaccine. A total of 3937 subjects were recruited and 2754 (70% met all protocol criteria at the end of the study. All the subjects were considered healthy and denied having received hepatitis B vaccine before the study. Study subjects who adhered to the protocol were newborn infants (566, children 1 to 10 years old (484, adolescents from 11 to 19 years (740, adults from 20 to 30 years (568, and adults from 31 to 40 years (396. Vaccine was administered in three doses on the schedule 0, 1, and 6 months (newborn infants, adolescents, and adults or 0, 1, and 7 months (children. Vaccine dose was intramuscular 10 µg (infants, children, and adolescents or 20 µg (adults. Percent seroprotection (assumed when anti-HBs titers were > 10mIU/ml and geometric mean titer (mIU/ml were: newborn infants, 93.7% and 351.1 (Butang® and 97.5% and 1530.6 (Engerix B®; children, 100% and 3600.0 (Butang® and 97.7% and 2753.1 (Engerix B®; adolescents, 95.1% and 746.3 (Butang® and 96% and 1284.3 (Engerix B®; adults 20-30 years old, 91.8% and 453.5 (Butang® and 95.5% and 1369.0 (Engerix B®; and adults 31-40 years old, 79.8% and 122.7 (Butang® and 92.4% and 686.2 (Engerix B®. There were no severe adverse events following either vaccine. The study concluded that Butang® was equivalent to Engerix B® in children, and less immunogenic but acceptable for use in newborn infants, adolescents, and young adults.

  1. Recalculation of loads on LOFT penetrations 1A, 2A, 3E, 3F, 5A, 5B, 5C, 5D, 5E, 5F, 7A, 9A, 11C, 17A, 17B, 20A, 20B, 20C, 21A

    International Nuclear Information System (INIS)

    McFadden, D.F.

    1978-01-01

    The loads on the piping nozzles penetrating the LOFT containment vessel are presented. Since the design and construction of the containment vessel, piping systems that penetrate the nozzles have been changed. Consequently, the moments and forces on the containment vessel are different than those stated in LOFT specification S-1. Two combined load cases were tabulated, deadweight plus thermal expansion plus operating basis earthquake and deadweight plus safe shutdown earthquake

  2. Management of Third Stage of Labour with Per Rectal Administration of 400 MCG of Tablet Misoprostol Before Delivery of Placenta - Protocol for 3rd Stage of Labour - A Pilot Study

    Directory of Open Access Journals (Sweden)

    Pragati Tugnait

    2015-01-01

    Conclusion: The third stage of labour poses potentially life threatening risks and several severe complications to a mother who has just delivered. The patients in rural and peripheral setups are more vulnerable given their poor nutritional status, rare health care facilities, non availability of trained birth attendants and distance to a tertiary care centre. In larger centres also ,avoidance of post partum haemorrhage adds to maternal well being and saves on hospital resources in terms of man and material. The mean blood loss of 163.41 ml during third stage of labour is an encouraging result especially when no significant side effects were noted.

  3. Aceptance of Hepatitis B vaccine by workers in a Nigerian Teaching ...

    African Journals Online (AJOL)

    Subjects: A total of 2,548 employees of the teaching hospital that have worked for a minimum of one year on a continuous basis between April 1992 and December 1995. Interventions: Procurement of recombinant hepatitis B vaccine (Engerix®, SmithKline Beecham) by the hospital management and provision of the same to ...

  4. Hepatitis B vaccination in prison with a 3-week schedule is more efficient than the standard 6-month schedule

    DEFF Research Database (Denmark)

    Christensen, Peer B; Fisker, Niels; Krarup, Henrik B

    2004-01-01

    A randomized study of injecting drug users in a Danish prison comparing vaccination at 0, 1 and 3 weeks with the 0, 1 and 6 months schedule (20microg Engerix B i.m.) was conducted. Due to a low participation rate, a second nonrandomized study was conducted in Estonia where all prisoners were vacc...

  5. Comparison of two recombinant hepatitis B vaccines and their interchangeability in Argentine infants Comparación de dos vacunas recombinantes contra la hepatitis B y su intercambiabilidad en lactantes argentinos

    Directory of Open Access Journals (Sweden)

    Miguel Tregnaghi

    2004-01-01

    Full Text Available OBJECTIVE: To compare two pediatric recombinant hepatitis B vaccines-the Engerix-B reference vaccine and the Euvax-B vaccine-in terms of immunogenicity and reactogenicity, and also to investigate their interchangeability, that is, whether a three-dose hepatitis B vaccination schedule begun with a first dose of Engerix-B could be completed with two doses of Euvax-B. METHODS: This study was conducted in the city of Córdoba, Argentina, from March 1999 through February 2000. Three groups of Argentine newborns (100 per group were vaccinated at 0, 1, and 6 months of age with hepatitis B vaccine: group A, three doses of Euvax-B; group B, three doses of Engerix-B; and group C, one dose of Engerix-B followed by two doses of Euvax-B. Reactogenicity was evaluated based on parental reporting of any solicited local or systemic event occurring during the 7-day period following vaccination. Whether Euvax-B and Engerix-B were clinically identical was assessed in terms of the seroprotection rates (antibodies to hepatitis B surface antigen (anti-HBsAg >10 milli-international units per mL (mIU/mL 2 months after the third vaccination. RESULTS: Reactogenicity was low in all three groups. Five months after the second dose (that is, immediately prior to the third vaccination, seroprotection rates were 95.9%, 94.7%, and 90.2% for groups A, B, and C, respectively. Two months after the third dose all subjects were seroprotected, with geometric mean concentrations of anti-HBsAg of 2 468.1, 1 714.8, and 2 075.3 mIU/mL for groups A, B, and C, respectively. CONCLUSIONS: Both of the recombinant hepatitis B vaccines that we studied were well tolerated and highly immunogenic. Euvax-B was clinically identical (not inferior to the Engerix-B reference vaccine, and either vaccine could be used to achieve the World Health Organization goal of immunizing all infants against hepatitis B. Further, Euvax-B can be safely used in infants given an initial dose of either Euvax-B or Engerix

  6. Animal magnetocardiography using superconducting quantum interference device gradiometers assisted with magnetic nanoparticle injection: A sensitive method for early detecting electromagnetic changes induced by hypercholesterolemia

    Science.gov (United States)

    Wu, C. C.; Hong, B. F.; Wu, B. H.; Yang, S. Y.; Horng, H. E.; Yang, H. C.; Tseng, W. Y. Isaac; Tseng, W. K.; Liu, Y. B.; Lin, L. C.; Lu, L. S.; Lee, Y. H.

    2007-01-01

    In this work, the authors used a superconducting quantum interference device (SQUID) magnetocardiography (MCG) system consisted of 64-channel low-transition-temperature SQUID gradiometers to detect the MCG signals of hepercholesterolemic rabbits. In addition, the MCG signals were recorded before and after the injection of magnetic nanoparticles into the rabbits' ear veins to investigate the effects of magnetic nanoparticles on the MCG signals. These MCG data were compared to those of normal rabbits to reveal the feasibility for early detection of the electromagnetic changes induced by hypercholesterolemia using MCG with the assistance of magnetic nanoparticle injection.

  7. Scanning high-Tc SQUID imaging system for magnetocardiography

    International Nuclear Information System (INIS)

    Yang, H-C; Wu, T-Y; Horng, H-E; Wu, C-C; Yang, S Y; Liao, S-H; Wu, C-H; Jeng, J T; Chen, J C; Chen, Kuen-Lin; Chen, M J

    2006-01-01

    A scanning magnetocardiography (MCG) system constructed from SQUID sensors offers potential to basic or clinical research in biomagnetism. In this work, we study a first order scanning electronic high-T c (HTS) SQUID MCG system for biomagnetic signals. The scanning MCG system was equipped with an x-y translation bed powered by step motors. Using noise cancellation and μ-metal shielding, we reduced the noise level substantially. The established scanning HTS MCG system was used to study the magnetophysiology of hypercholesterolaemic (HC) rabbits. The MCG data of HC rabbits were analysed. The MCG contour map of HC rabbits provides experimental models for the interpretation of human cardiac patterns

  8. Properties of coaxial magnetocumulative generators

    International Nuclear Information System (INIS)

    Kidder, R.E.

    1983-01-01

    The properties of a coaxial magnetocumulative generator (MCG) in which the current increases exponetially with time are derived and discussed. Such an exponential MCG possess highly desirable performance characteristics that are readily derived and expressed in terms of simple formulas. It is concluded that an exponential MCG may approach a capability of delivering 100 megajoules to a 1 nanohenry load in 1 microsecond

  9. Protective effect of Adeturone on E.coli survival

    International Nuclear Information System (INIS)

    Baldzhijska, M.; Minkova, M.; Pantev, T.

    1980-01-01

    Antiradiation potencies of AET, ATP, and the preparation Adeturone (AET salt of ATP) were studied in terms of E.coli survival following exposure to gamma-ray doses ranging from 1.29 K/kg to 20.64 K/kg AET was found to provide protection only in the case of the highest of three concentrations used, 625 micrograms per milliliter. ATP concentrations of 587 mcg/ml proved ineffective whether used solely or in a mixture with 262.5 mcg/ml of AET. These ineffective AET and ATP concentrations are equimolar with the amounts of AET and ATP contained in Adeturone. The latter showed a protective effect when applied at 625 mcg/ml, but failed to protect at a lower (312 mcg/ml) or at higher (1250 mcg/ml and 1500 mcg/ml) concentrations. Confirmative evidence was thus obtained that chemical binding of the two protectors raises the effectiveness of the combination

  10. Protective effect of Adeturone on E. coli survival

    Energy Technology Data Exchange (ETDEWEB)

    Baldzhijska, M; Minkova, M; Pantev, T [Meditsinska Akademiya, Sofia (Bulgaria). Nauchen Inst. po Rentgenologiya i Radiobiologiya

    1980-01-01

    Antiradiation potencies of AET, ATP, and the preparation Adeturone (AET salt of ATP) were studied in terms of E.coli survival following exposure to gamma-ray doses ranging from 1.29 K/kg to 20.64 K/kg AET was found to provide protection only in the case of the highest of three concentrations used, 625 micrograms per milliliter. ATP concentrations of 587 mcg/ml proved ineffective whether used solely or in a mixture with 262.5 mcg/ml of AET. These ineffective AET and ATP concentrations are equimolar with the amounts of AET and ATP contained in Adeturone. The latter showed a protective effect when applied at 625 mcg/ml, but failed to protect at a lower (312 mcg/ml) or at higher (1250 mcg/ml and 1500 mcg/ml) concentrations. Confirmative evidence was thus obtained that chemical binding of the two protectors raises the effectiveness of the combination.

  11. Autecology of crenarchaeotal and bacterial clades in marine sediments and microbial mats

    OpenAIRE

    Kubo, Kyoko

    2011-01-01

    The focus of this thesis was the autecology of the Miscellaneous Crenarchaeotal Group (MCG), a phylum-level clade of Archaea occurring mostly in marine sediments. Sequences of MCG 16S rRNA genes have been retrieved from a wide range of marine and terrestrial habitats, such as deep subsurface sediments, hydrothermal sediments, mud volcanoes, estuaries, hot springs and freshwater lake sediments. MCG members seem to have no general preferences for a particular temperature or salinity. So far, no...

  12. Georgia - Energy Rehabilitation

    Data.gov (United States)

    Millennium Challenge Corporation — Gustavson Associates was retained by Millennium Challenge Georgia (MCG) to prepare a model to calculate the economic rate of return (ERR) for rehabilitation work...

  13. 21 CFR 101.79 - Health claims: Folate and neural tube defects.

    Science.gov (United States)

    2010-04-01

    ... pregnancy had a reduced risk of having a child with a neural tube defect. (Products containing this level of... neural tube defect, those with insulin-dependent diabetes mellitus, and women with seizure disorders who... mcg) when labeled for use by adults and children 4 or more years of age, or 800 mcg when labeled for...

  14. Review of Magneto cardiography Technology based on SQUID

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. H.; Kwon, H.; Kim, J. M.; Kim, K.; Yu, K. K.; Park, Y. K. [Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2012-04-15

    Electric activity of cardiac muscles generates magnetic fields. Magnetocardiography (or MCG) technology, measuring these magnetic signals, can provide useful information for the diagnosis of heart diseases. It is already about 40 years ago that the first measurement of MCG signals was done by D. Cohen using SQUID (superconducting quantum interference device) sensor inside a magnetically shielded room. In the early period of MCG history, bulky point-contact RF-SQUID was used as the magnetic sensor. Thanks to the development of Nb-based Josephson junction technology in mid 1980s and new design of tightly-coupled DC-SQUID, low-noise SQUID sensors could be developed in late 1980s. In around 1990, several groups developed multi-channel MCG systems and started clinical study. However, it is quite recent years that the true usefulness of MCG was verified in clinical practice, for example, in the diagnosis of coronary artery disease. For the practical MCG system, technical elements of MCG system should be optimized in terms of performance, fabrication cost and operation cost. In this review, development history, technical issue, and future development direction of MCG technology are described.

  15. Mycelial compatibility groups and pathogenicity of Sclerotinia ...

    African Journals Online (AJOL)

    ... was determined by mycelial compatibility grouping (MCG) and isolate aggressiveness comparisons. MCG, host specificity and aggressiveness of S. sclerotiorum isolates were assessed. Isolate pairs were designated compatible when no barrage zone formed at sites of contact. They were designated incompatible when a ...

  16. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Cosmological models with modified Chaplygin gas (MCG) in the framework of Horava–Lifshitz (HL) theory of gravity, both with and without detailed balance, are obtained. The equation of state (EOS) for a MCG contains three unknown parameters namely, , , . The allowed values of some of these parameters of the EOS ...

  17. Estudio de inmunogenicidad para dos vacunas recombinantes contra hepatitis B

    Directory of Open Access Journals (Sweden)

    O. Juliao

    1991-12-01

    Full Text Available Este estudio compara la inmunogenicidad (seroconversión, seroprotección e Hiperrespuesta, producida por dos vacunas recombinantes contra la hepatitis B (Engerix-B de Bélgica y Cubana, en dos esquemas (012 y 016 meses, empleando los métodos de cuantificación para Anti-HBsAg (Abbott y Organón, los cuales fueron también comparados. En el estudio participaron 257 voluntarios,  divididos al azar en 4 grupos (dos vacunas, dos esquemas. Resultados: los dos métodos de Abbon y Organon, no presentan diferencias estadísticas significativas. La vacuna cubana muestra una mayor respuesta inmunogénica para dos dosis de vacuna y para el esquema 012. No hay diferencia entre los esquemas 012 y 016 y en el esquema 016 no se ven diferencias estadísticamente significativas con la vacuna Engerix-B. En esta Última el esquema 016 muestra mejores resultados que el 012.

  18. Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study

    Directory of Open Access Journals (Sweden)

    Charu Singh

    2016-01-01

    Full Text Available True tinnitus is a phantom auditory perception arising from a source or trigger in the cochlea, brainstem, or at higher centers and has no detectable acoustic generator. The most accepted is the famous neurophysiologic model of Jastreboff, which stresses that tinnitus, is a subcortical perception and results from the processing of weak neural activity in the periphery. The aim of this study is to determine the role of Vitamin B12 in treatment of chronic tinnitus. In this randomized, double-blind pilot study, total 40 patients were enrolled, of which 20 in Group A (cases received intramuscular therapy of 1 ml Vitamin B12 (2500 mcg weekly for a period of 6 weeks and Group B (20 patients received placebo isotonic saline 01 ml intramuscular. The patients were subjected to Vitamin B12 assay and audiometry pre- and post-therapy. Of the total patients of tinnitus, 17 were Vitamin B12 deficient that is 42.5% showed deficiency when the normal levels were considered to be 250 pg/ml. A paired t-test showed that in Group A, patients with Vitamin B12 deficiency showed significant improvement in mean tinnitus severity index score and visual analog scale (VAS after Vitamin B12 therapy. This pilot study highlights the significant prevalence of Vitamin B12 deficiency in North Indian population and improvement in tinnitus severity scores and VAS in cobalamin-deficient patients receiving intramuscular Vitamin B12 weekly for 6 weeks further provides a link between cobalamin deficiency and tinnitus thereby suggestive of a therapeutic role of B12 in cobalamin-deficient patients of tinnitus.

  19. Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study.

    Science.gov (United States)

    Singh, Charu; Kawatra, Rahul; Gupta, Jaya; Awasthi, Vishnu; Dungana, Homnath

    2016-01-01

    True tinnitus is a phantom auditory perception arising from a source or trigger in the cochlea, brainstem, or at higher centers and has no detectable acoustic generator. The most accepted is the famous neurophysiologic model of Jastreboff, which stresses that tinnitus, is a subcortical perception and results from the processing of weak neural activity in the periphery. The aim of this study is to determine the role of Vitamin B12 in treatment of chronic tinnitus. In this randomized, double-blind pilot study, total 40 patients were enrolled, of which 20 in Group A (cases) received intramuscular therapy of 1 ml Vitamin B12 (2500 mcg) weekly for a period of 6 weeks and Group B (20) patients received placebo isotonic saline 01 ml intramuscular. The patients were subjected to Vitamin B12 assay and audiometry pre- and post-therapy. Of the total patients of tinnitus, 17 were Vitamin B12 deficient that is 42.5% showed deficiency when the normal levels were considered to be 250 pg/ml. A paired t-test showed that in Group A, patients with Vitamin B12 deficiency showed significant improvement in mean tinnitus severity index score and visual analog scale (VAS) after Vitamin B12 therapy. This pilot study highlights the significant prevalence of Vitamin B12 deficiency in North Indian population and improvement in tinnitus severity scores and VAS in cobalamin-deficient patients receiving intramuscular Vitamin B12 weekly for 6 weeks further provides a link between cobalamin deficiency and tinnitus thereby suggestive of a therapeutic role of B12 in cobalamin-deficient patients of tinnitus.

  20. Mixed crude glycerin in laying hen diets: live performance and egg quality and fatty acid profile

    Directory of Open Access Journals (Sweden)

    CRA Duarte

    2014-12-01

    Full Text Available This study evaluated the performance and the quality and fatty acid profile of eggs from laying hens fed diets containing mixed crude glycerin (MCG; 80% vegetable fat + 20% animal fat. A total of 240 39-week-old Hy-Line W36 laying hens were distributed according to a completely randomized experimental design into six treatments consisting of graded MCG dietary inclusion levels (0, 1.5, 3.0, 4.5, 6.0, and 7.5%, with five replicates of eight birds each. Feed intake linearly decreased (p<0.05 with increasing MCG inclusion levels. The percentages of myristic, palmitic, and α-linolenic acids in the eggs linearly decreased as MCG dietary levels increased (p<0.05, while α-linoleic acid, polyunsaturated fatty acids (PUFA and ω-6/ω-3 ratio linearly increased. Excreta moisture linearly increased with increasing levels of MCG inclusion (p<0.05. MCG may be included in up to 7.5% in layer feeds without impairing performance or egg quality, but levels up to 5.54% reduce SFA egg content. However, the inclusion of MCG in layer diets increases ω-6/ω-3 ratio in the eggs.

  1. Heterogeneity of FeNO response to inhaled steroid in asthmatic children

    DEFF Research Database (Denmark)

    Buchvald, F; Eiberg, H; Bisgaard, H

    2003-01-01

    synthethase 1 (NOS1) gene were studied in a double-blind, placebo-controlled crossover comparison of budesonide (BUD) Turbohaler 1600 mcg daily vs. placebo in asthmatic schoolchildren. RESULTS: Forty children were included in the study from a screening of 184 asthmatic children with moderately persistent...... asthma, well controlled on regular BUD 400 mcg daily: 20 children with normal FeNO and 20 with raised FeNO. FeNO, BHR and forced expiratory volume in 1 s improved significantly after BUD 1600 mcg (BUD1600). However, FeNO after ICS treatment exhibited a Gaussian distribution and FeNO was significantly...

  2. In Vitro Activity of Ceftolozane-Tazobactam against Burkholderia pseudomallei.

    Science.gov (United States)

    Slack, Andrew; Parsonson, Fiona; Cronin, Katie; Engler, Kathy; Norton, Robert

    2018-06-25

    We investigated the in vitro activity of a novel fifth-generation cephalosporin-tazobactam combination, ceftolozane-tazobactam against Burkholderia pseudomallei , the etiological agent of melioidosis. Using both disc diffusion and minimum inhibitory concentration (MIC) strip techniques against 56 clinical isolates and an NCTC strain, the MIC to ceftolozane-tazobactam was found to be between 0.75 and 4 mcg/mL. The MIC50 was found to be 1.5 mcg/mL and MIC90 was 2.0 mcg/mL. This study provides initial evidence of ceftolozane-tazobactam as a novel agent in the management of melioidosis.

  3. Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in Tanzanian children aged 12–24 months

    Directory of Open Access Journals (Sweden)

    Segeja Method D

    2009-07-01

    Full Text Available Abstract Background Development and deployment of an effective malaria vaccine would complement existing malaria control measures. A blood stage malaria vaccine candidate, Merozoite Surface Protein-3 (MSP3, produced as a long synthetic peptide, has been shown to be safe in non-immune and semi-immune adults. A phase Ib dose-escalating study was conducted to assess the vaccine's safety and immunogenicity in children aged 12 to 24 months in Korogwe, Tanzania (ClinicalTrials.gov number: NCT00469651. Methods This was a double-blind, randomized, controlled, dose escalation phase Ib trial, in which children were given one of two different doses of the MSP3 antigen (15 μg or 30 μg or a control vaccine (Engerix B. Children were randomly allocated either to the MSP3 candidate malaria vaccine or the control vaccine administered at a schedule of 0, 1, and 2 months. Immunization with lower and higher doses was staggered for safety reasons starting with the lower dose. The primary endpoint was safety and reactogenicity within 28 days post-vaccination. Blood samples were obtained at different time points to measure immunological responses. Results are presented up to 84 days post-vaccination. Results A total of 45 children were enrolled, 15 in each of the two MSP3 dose groups and 15 in the Engerix B group. There were no important differences in reactogenicity between the two MSP3 groups and Engerix B. Grade 3 adverse events were infrequent; only five were detected throughout the study, all of which were transient and resolved without sequelae. No serious adverse event reported was considered to be related to MSP3 vaccine. Both MSP3 dose regimens elicited strong cytophilic IgG responses (subclasses IgG1 and IgG3, the isotypes involved in the monocyte-dependant mechanism of Plasmodium falciparum parasite-killing. The titers reached are similar to those from African adults having reached a state of premunition. Furthermore, vaccination induced seroconversion in

  4. Observational constraints on modified Chaplygin gas in Horava ...

    Indian Academy of Sciences (India)

    Corresponding author. E-mail: ... greater the dark radiation less the matter contribution in the MCG in both the scenario considered here. In order to check .... like a cosmological constant, accounting for the observed features of the Universe. It.

  5. 48 CFR 245.102 - Policy.

    Science.gov (United States)

    2010-10-01

    ... DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.102 Policy. (1) Mapping, charting, and geodesy property. All Government-furnished mapping, charting, and geodesy (MC&G) property is under the control of...

  6. Analgesic efficacy of low-dose intrathecal neostigmine in combination with fentanyl and bupivacaine for total knee replacement surgery

    Directory of Open Access Journals (Sweden)

    Amit Jain

    2012-01-01

    Conclusions: The addition of 1 mcg neostigmine IT increased the duration of analgesia and decreased the analgesic consumption in 24 h in TKR. There was no increase in the incidence of adverse effects.

  7. Allogeneic Peripheral Blood Stem Cell Harvest

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Allogeneic Peripheral Blood Stem Cell Harvest. Mobilization protocol. G-CSF 10 mcg/Kg / day for 5 days. Pheresis. Cobe Spectra; Haemonetics mcs+. Enumeration. CD34 counts; Cfu-GM assays.

  8. Energy and technology review

    Energy Technology Data Exchange (ETDEWEB)

    Selden, R.W.

    1977-05-01

    Topics covered include: geothermal energy development at LLL, energy conversion engineering, continuing education at LLL, and the Western states uranium resource survey. Separate abstracts were prepared for 3 sections. (MCG)

  9. Digital Mapping Charting and Geodesy analysis Program (DMAP) Review of Technical Initiatives for FY03

    National Research Council Canada - National Science Library

    Breckenridge, John

    2003-01-01

    The Naval DMAP serves as a technical representative for the Oceanographer of the Navy, NO96 to address significant issues relevant to the Navy's use and development of digital Mapping, Charting & Geodesy (MC&G) data...

  10. Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes

    OpenAIRE

    Anderson, Collin; MacKay, Mark

    2015-01-01

    Purpose: Determine the stability of fentanyl 10 mcg/mL in 0.9% sodium chloride, fentanyl 10 mcg/mL in 5% dextrose, fentanyl 50 mcg/mL, hydromorphone 100 mcg/mL in 0.9% sodium chloride, ketamine 10 mg/mL, midazolam 0.4 mg/mL in 5% dextrose, midazolam 5 mg/mL, morphine 1 mg/mL in 0.9% sodium chloride, morphine 1 mg/mL in 5% dextrose, and pentobarbital 50 mg/mL when stored as single drug entities at room temperature in polypropylene syringes. Methods: Four 5 mL samples of each drug and concentra...

  11. What Every Textbook Evaluator Should Know.

    Science.gov (United States)

    Muther, Connie

    1985-01-01

    Presents information on textbook design and marketing practices, and their consequences for textbook content; recommends that selection committees firmly define the role of the textbook in curriculum, and adapt published materials to their school system's unique requirements. (MCG)

  12. Burkina Faso - Roads Baseline Survey

    Data.gov (United States)

    Millennium Challenge Corporation — NOTE !!!This survey data was not used for any independent evaluation reports!!! Impaq worked with the data collection firms NSCE-MCG-AC3E [the Group] to conduct...

  13. Construction machine control guidance implementation strategy.

    Science.gov (United States)

    2010-07-01

    Machine Controlled Guidance (MCG) technology may be used in roadway and bridge construction to improve construction efficiencies, potentially resulting in reduced project costs and accelerated schedules. The technology utilizes a Global Positioning S...

  14. Jeremiad and Curriculum: The Haunting of the Secondary School.

    Science.gov (United States)

    Greene, Maxine

    1985-01-01

    Discusses the "American jeremiad"--a pervasive ideological theme portraying a national mission and our failures in achieving it--and the influence of this ideology on elementary and secondary education. (MCG)

  15. Federal Procurement Standards Applied to School Food Services.

    Science.gov (United States)

    VanEgmond-Pannell, Dorothy

    1984-01-01

    Explains standards laid out in Federal Circular A-120 to ensure accountability, uniformity of standards, legal compliance, and efficiency in school food service procurement. Includes bidding and contract award procedures, contract compliance considerations, and cost-cutting methods. (MCG)

  16. Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a multiple ascending dose study in opioid-naïve healthy volunteers.

    Science.gov (United States)

    Rauck, Richard L; Oh, D Alexander; Singla, Neil; Koch, Christian; Parikh, Neha; Nalamachu, Srinivas; Wilson, Daniel; Yu, Jin; Vetticaden, Santosh

    2017-11-01

    Fentanyl sublingual spray, with its rapid onset for pain relief, may be efficacious in the management of acute or post-operative pain. Because patients in these settings may be opioid-naïve, the study was conducted to determine the safety, tolerability, and pharmacokinetics of multiple dose administration of fentanyl sublingual spray in an opioid-naïve population. Fentanyl sublingual spray (100 mcg, 200 mcg, and 400 mcg) and fentanyl citrate intravenous (IV; 50 mcg) were administered every 0.5, 1.0, 2.0, and 4.0 h for up to three doses per cohort in opioid-naïve subjects (ClinicalTrials.gov identifier: NCT02641340). Eight subjects in each cohort were randomly assigned (six subjects received fentanyl sublingual spray; two subjects received fentanyl citrate IV). Pharmacokinetic and safety-related pharmacodynamic assessments were performed through 24 h post-first dose. Safety assessments were collected through Day 7. Ninety-six opioid-naïve subjects, aged 20-55 years, with a body mass index of 18.7-31.5 kg/m 2 , participated in the study. Multiple doses of fentanyl sublingual spray (100, 200, and 400 mcg) were generally well tolerated. Hypoxia, observed in the 200-mcg and 400-mcg dose groups, increased with increasing doses and higher dosing frequency, but was readily managed by nasal cannula oxygenation. Overall, nausea increased with increasing doses, and ∼52.6% (10 out of 19) cases of nausea that occurred at the highest dose of 400 mcg were treated with concomitant medication. Overall, the reported adverse events were consistent with the known safety profile of fentanyl. Fentanyl sublingual spray (100 mcg, 200 mg, and 400 mcg) administered every 0.5, 1, 2, and 4 h was generally well tolerated in an opioid-naïve population. The results suggest that doses of 200 mcg or lower may be safe for use in an opioid-naïve population.

  17. Perfil de sensibilidade aos antimicrobianos e eficácia de sanitizantes frente aos isolados de Salmonella spp. oriundos de carcaças suínas no Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Fernanda Lucia Colla

    2014-04-01

    Full Text Available Os objetivos do trabalho foram avaliar o perfil de sensibilidade a antimicrobianos e a eficácia de três sanitizantes frente a isolados de Salmonella spp. oriundos de carcaças na tecnologia de abate de suínos. Avaliaram-se 120 amostras, das quais 39 foram positivas para Salmonella spp. Os princípios ativos testados foram penicilina G 10 U, amoxicilina + ácido clavulânico 30mcg, ampicilina 10mcg, cloranfenicol 30mcg, tetraciclina 30mcg, estreptomicina 10mcg, neomicina 30mcg, gentamicina 10mcg, enrofloxacina 5mcg, sulfazotrim 25mcg, sulfonamida 300mcg e trimetropima 5mcg. Nos testes com sanitizantes utilizaram-se clorexidina, amônia quaternária e ácido peracético com tempos de contato de um, cinco, 10 e 15 minutos. Os índices de resistência aos antimicrobianos foram de 100% para penicilina, 94,9% para tetraciclina, 89,7% para trimetropima e 87,2% para ampicilina. Nenhum dos princípios ativos foi 100% eficaz frente aos isolados testados, observando-se melhor ação para amoxicilina+ácido clavulânico (86,7%, neomicina (86,7% e cloranfenicol (64,1%. Nos testes de eficácia dos sanitizantes, o ácido peracético a 0.5% foi efetivo a partir de 10 minutos (94,6% e 15 minutos (97,3% de contato; amônia quaternária a 1% por 10 minutos (89,2% e 15 minutos (97,3% e clorexidina a 0.5% por 10 minutos (70,3% e 15 minutos de contato (72,8%. Todas as amostras testadas apresentaram multirresistência e seis (15,3% apresentaram resistência à ampicilina, cloranfenicol, estreptomicina, sulfonamida e tetraciclina (denominado grupo ACSSuT, indicando a necessidade de monitorar a propagação da resistência aos antimicrobianos em Salmonella spp. oriundas de suínos. O sanitizante mais efetivo frente aos isolados testados foi o ácido peracético a 0.5% por 15 minutos, reforçando a necessidade de monitorar também a efetividade de produtos sanitizantes frente aos isolados de Salmonella spp.

  18. Transformer supply of inductive and resistive loads of a magnetocumulative generator

    International Nuclear Information System (INIS)

    Kravchenko, A.S.; Lyudaev, R.Z.; Pavlovskij, A.I.; Plyashkevich, L.N.; Shuvalov, A.M.

    1981-01-01

    Variants of transformer energy outlet from magnetocumulative generator (MCG) to inductive and resistive loads are considered. For engineer calculations of transformer MCG electrotechnical model supplemented with a known from the experiment fact of existence of optimum by energy generator finite inductivity turns to be useful. The possibility of current front shortening in the load using a transformer idle running and current pulse shaping at current damping upon the finishing of generator performance is considered [ru

  19. Drug distribution and stability in extemporaneous preparations of meloxicam and carprofen after dilution and suspension at two storage temperatures.

    Science.gov (United States)

    Hawkins, Michelle G; Karriker, Margo J; Wiebe, Valerie; Taylor, Ian T; Kass, Philip H

    2006-09-15

    To determine dispersion uniformity and stability of meloxicam and carprofen in extemporaneous preparations stored for 28 days. Prospective study. Meloxicam and carprofen (commercial formulations) were compounded (day 0) with deionized water (DW), 1% methylcellulose gel (MCG), MCG and simple syrup (SS; 1:1 mixture), or a suspending and flavoring vehicle combination (SFVC; 1:1 mixture) to nominal drug concentrations of 0.25, 0.5, or 1.0 mg/mL and 1.25, 2.5, or 5.0 mg/mL, respectively. Preparations were stored at approximately 4 degrees C (39.2 degrees F) or 22 degrees C (71.6 degrees F). For each preparation, drug concentrations were determined and drug stability was evaluated at intervals during storage; on days 0 and 28, pH values were measured and bacterial cultures were initiated. In meloxicam-DW, meloxicam-MCG (0.25 mg/mL), and meloxicam-MCG (0.5 mg/mL) preparations, drug distribution was uniform (coefficient of variation 90% of the original drug concentration was maintained for 28 days. Despite uniform drug distribution of the carprofen-SFVC preparations, most retained > or = 90% of the original drug concentration for only 21 days. Use of the MCG-SS combination resulted in foamy preparations of unacceptable variability. After 28 days, pH decreased slightly in meloxicam-DW and meloxicam-MCG preparations (0.17 +/- 0.04 and 0.21 +/- 0.04, respectively). Carprofen-SFVC (2.5 mg/mL) and carprofen-MCG-SS (5.0 mg/mL) preparations stored at 22 degrees C for 28 days yielded bacterial growth. DW, MCG, and the SFVC can be used successfully for extemporaneous preparation of meloxicam and carprofen for administration to small exotic animals. Refrigeration is recommended for preparations of meloxicam-DW and carprofen-SFVC.

  20. Center vortex properties in the Laplace center gauge of SU(2) Yang-Mills theory

    OpenAIRE

    Langfeld, K.; Reinhardt, H.; Schafke, A.

    2001-01-01

    Resorting to the the Laplace center gauge (LCG) and to the Maximal-center gauge (MCG), respectively, confining vortices are defined by center projection in either case. Vortex properties are investigated in the continuum limit of SU(2) lattice gauge theory. The vortex (area) density and the density of vortex crossing points are investigated. In the case of MCG, both densities are physical quantities in the continuum limit. By contrast, in the LCG the piercing as well as the crossing points li...

  1. Cardiomagnetic source imaging

    OpenAIRE

    Pesola, Katja

    2000-01-01

    Magnetocardiographic (MCG) source imaging has received increasing interest in recent years. With a high enough localization accuracy of the current sources in the heart, valuable information can be provided, e.g., for the pre-ablative evaluation of arrhythmia patients. Furthermore, preliminary studies indicate that ischemic areas, i.e. areas which are suffering from lack of oxygen, and infarcted regions could be localized from multichannel MCG recordings. In this thesis, the accuracy of cardi...

  2. Avaliacao da seguranca de diferentes doses de suplementos de acido folico em mulheres do Brasil

    Directory of Open Access Journals (Sweden)

    Quenia dos Santos

    2013-10-01

    Full Text Available OBJETIVO Avaliar a distribuição da ingestão de ácido fólico e a segurança de diferentes doses de suplementos em mulheres em idade reprodutiva. MÉTODOS Foram utilizados dados de consumo a partir de dois dias não consecutivos de registro alimentar de 6.837 mulheres em idade reprodutiva (19 a 40 anos participantes do Inquérito Nacional de Alimentação, módulo da Pesquisa de Orçamentos Familiares 2008-2009. Médias e percentis de consumo habitual de folato natural e ácido fólico foram estimados utilizando o método do National Cancer Institute . Cinco cenários foram simulados somando-se diferentes doses diárias de fortificação (400 mcg, 500 mcg, 600 mcg, 700 mcg e 800 mcg ao ácido fólico oriundo dos alimentos consumidos pelas mulheres. Comparou-se o total de ácido fólico (dieta + suplemento com o nível máximo de ingestão tolerável (UL = 1.000 mcg para definir a dose segura de suplementação. RESULTADOS Mulheres com ingestão habitual de ácido fólico acima do nível máximo de ingestão tolerável foram observadas para doses de suplemento de 800 mcg (7,0% das mulheres. Abaixo desse valor, qualquer dose de suplementação mostrou-se segura. CONCLUSÕES O uso de suplementos de até 700 mcg de ácido fólico mostrou-se seguro.

  3. Age-dependent decrease of anti-HBs titers and effect of booster doses using 2 different vaccines in Palestinian children vaccinated in early childhood

    Science.gov (United States)

    Qawasmi, Mohammad; Samuh, Monjed; Glebe, Dieter; Gerlich, Wolfram H; Azzeh, Maysa

    2015-01-01

    Immunization against hepatitis B virus (HBV) has proven to be highly effective and led to significant reduction of new infections worldwide. However, protective immunity measured by anti-HBs titers may decrease to critical levels in the years after basal immunization, particularly in case of exposure to HBV variants different from the vaccine strain. We tested 400 Palestinian children between one and 19 years of age for their anti-HBs titer, challenged the immune memory of those with low or absent anti-HBs with 2 types of hepatitis B vaccines and determined thereafter the anti-HBs titer. At the age of one, 92.2% of the children presented with protective anti-HBs titers (≥10 mIU/ml) with the majority having ≥100 mIU/ml. Protective immunity was still high at ages 2 (87.5%) and 4 (95%), declining by age 5 and 6 (from 69.2% to 66.7%) and down to an average of 39.8% between the ages of 7 and 19. 160 children with a nonprotective or low immune response challenged with either the yeast-derived Engerix-B or the mammalian cell-derived preS1-containing Sci-B-Vac vaccine showed an anamnestic immune response. 92.4% and 85.9% of the children challenged with one dose Sci-B-Vac and Engerix-B presented with anti-HBs titers >100 mIU/ml respectively. Our results reveal that vaccine-induced protective anti-HBs titers against HBV decrease rapidly beyond the age of 6 in Palestinian children, but can be strongly enhanced with a single booster vaccine dose, independent of brand and antigen composition. Our data suggest that a booster vaccine dose against HBV during school years may be useful. PMID:25996579

  4. Simulation study of a magnetocardiogram based on a virtual heart model: effect of a cardiac equivalent source and a volume conductor

    International Nuclear Information System (INIS)

    Shou Guo-Fa; Xia Ling; Dai Ling; Ma Ping; Tang Fa-Kuan

    2011-01-01

    In this paper, we present a magnetocardiogram (MCG) simulation study using the boundary element method (BEM) and based on the virtual heart model and the realistic human volume conductor model. The different contributions of cardiac equivalent source models and volume conductor models to the MCG are deeply and comprehensively investigated. The single dipole source model, the multiple dipoles source model and the equivalent double layer (EDL) source model are analysed and compared with the cardiac equivalent source models. Meanwhile, the effect of the volume conductor model on the MCG combined with these cardiac equivalent sources is investigated. The simulation results demonstrate that the cardiac electrophysiological information will be partly missed when only the single dipole source is taken, while the EDL source is a good option for MCG simulation and the effect of the volume conductor is smallest for the EDL source. Therefore, the EDL source is suitable for the study of MCG forward and inverse problems, and more attention should be paid to it in future MCG studies. (general)

  5. Organochlorine accumulation by Sentinel Mallards at the Winston-Thomas sewage treatment plant, Bloomington, Indiana

    Science.gov (United States)

    Custer, T.W.; Sparks, D.W.; Sobiech, S.A.; Hines, R.K.; Melancon, M.J.

    1996-01-01

    Farm-raised l2-month-old female mallards (Anas platyrhynchos) were released at the Winston-Thomas sewage treatment plant, Bloomington, Indiana. Five mallards were sacrificed at the start of the study and at approximately 10-day intervals through day 100. Concentrations of polychlorinated biphenyls (PCBs) in carcasses increased linearly with time of exposure and exceeded 16 mcg/g wet weight by day 100; PCBs in breast muscle exceeded 3.9 mcg/g by day 100. These PCB values are among the highest recorded for wild or sentinel waterfowl. PCB concentrations in breast muscle (26-523 mcg/g lipid weight) were 50-1,000 times greater than human consumption guidelines for edible poultry in Canada (0.5 mcg/g lipid weight) and 9-176 times greater than consumption guidelines for edible poultry in the United States (3.0 mcg/g lipid weight). Additionally, PCB concentrations in carcass and breast muscle exceeded the threshold of the Great Lakes Sport Fish Consumption Advisory 'do not eat' category (1.9 mcg/g wet weight) by day 20 and day 50, respectively. Hepatic cytochrome P450-associated monooxygenases including BROD (benzyloxyresorufin-O-dealkylase), EROD (ethoxyresorufin-O-dealkylase), and PROD (pentoxyresorufin-O-dealkylase) were induced over 5-fold compared to reference mallards. BROD, EROD, and PROD were each significantly correlated to total PCBs and to the toxicity of selected PCB congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  6. Dynamics of Serum Pepsinogens on the Background of Double Standard Doses of Omeprazole in Patients with Gastroesophageal Reflux Disease and Functional Gastric Dyspepsia

    Directory of Open Access Journals (Sweden)

    S.G. Melashchenko

    2013-09-01

    Full Text Available In literature it has been reported that concentrations of serum pepsinogens increase during administration of proton pump inhibitors (PPI. However, the magnitude of these changes is still to be assessed. The aim of this study was to evaluate the changes in levels of pepsinogen I (PG-1 and pepsinogen II (PG-2 on the background of therapy with omeprazole which has been administered before breakfast in double standard dose (40 mg. The regimen of PPI administration completely corresponds to conventional PPI-test. There were two groups of patients: 1st one (gastroesophageal reflux desiase — 10 women and 9 men, mean age (52.37 ± 3.25 years; 2nd one (functional dyspepsia — 11 women and 8 men, mean age (48.37 ± 3.56 years. It was found that in 1st group PGI rises from (141.90 ± 7.99 mcg/l to (177.61 ± 7.81 mcg/l, in 2nd group — from (115.02 ± 10.16 mcg/l to (152.37 ± 12.33 mcg/l (p < 0.05. PG-2 level changes in the same. In 1st group PG-2 rises from (21.65 ± 3.13 mcg/l to (32.64 ± 3.42 mcg/l, in 2nd group — from (14.84 ± 1.64 mcg/l to (23.55 ± 2.37 mcg/l (p < 0.05. In 6 cases absolute increase of PGI (ΔPG-2 didn’t reach threshold of 7.0 mcg/l considered by us as level of insufficient acid inhibition. Two of these patients had atrophic gastritis (PG-1 < 50 mcg/l; ratio PG-/PG-2 < 3.0, rest 4 patients didn’t have atrophic gastritis but in half cases they hadn’t adequate answer to PPI administration. There was a significant correlation between increase of PG-1 level and disappearance of reflux complaints evaluated by dynamics in RS-cluster of GSRS-questionnaire.

  7. Stability of Dexmedetomidine in 0.9% Sodium Chloride in Two Types of Intravenous Infusion Bags.

    Science.gov (United States)

    Marquis, Kathleen; Hohlfelder, Benjamin; Szumita, Paul M

    2017-01-01

    Dexmedetomidine is a frequently used sedative in the critical care setting. It is commercially available as a 4-mg/mL premixed compound or as 200-mcg/2-mL vials that must be further diluted prior to administration. However, limited data exist regarding the stability of dexmedetomidine admixtures compounded from the 200-mcg/2-mL vials, particularly for durations greater than 48 hours. Therefore, we performed stability testing on compounded dexmedetomidine prepared in two types of intravenous infusion bags for 14 days. Dexmedetomidine is available as 200-mcg/2-mL vials for dilution, 80-mcg/20-mL single-dose vials, and as 200-mcg/50-mL and 400-mcg/100-mL glass bottles. The stability of dexmedetomidine admixtures has previously been tested for 48 hours. The purpose of this analysis was to test the stability of dexmedetomidine admixtures for 14 days. Six dexmedetomidine admixtures of 200 mcg/50 mL were compounded in polyvinyl chloride and non-polyvinyl chloride bags, three of which were stored under refrigeration and three of which were kept at room temperature. High-performance liquid chromatography testing was performed to determine the concentration at Days 1 through 14. Stability was determined by taking the mean concentration of samples taken from each bag. All samples were tested in duplicate. A sample was considered stable if the concentration was greater than 90% of the original concentration. All samples retained over 90% of the drug under their respective storage conditions for the duration of the study. At time 0, the concentration of dexmedetomidine was between 3.99 mcg/mL and 4.01 mcg/mL. On Day 14, the mean concentration was between 95.8% and 98.9%, depending on the bag type and storage condition. The pH remained between 4.7 and 5.8 during the study period as has previously been reported in the literature. Dexmedetomidine admixtures of 200 mcg/50 mL were stable in both polyvinyl chloride bags and non-polyvinyl chloride bags for 14 days under refrigeration

  8. CCDC 972510: Experimental Crystal Structure Determination : 8,21-bis(4-t-butylphenyl)-2,15-bis(2,6-diisopropylphenyl)-3a,5a,7,13a,16a,16b,20a,20b,22d,24a,26a,26b-dodecahydrobenzo[1,12]benzo[13',14']isoquinolino[6'',5'',4'':8',9',10']pentapheno[2',3':3,4]tetrapheno[9,8,7-def]isoquinoline-1,3,14,16(2H,15H)-tetrone toluene acetonitrile solvate

    KAUST Repository

    Das, Soumyajit

    2014-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  9. Adsorbent for p-phenylenediamine adsorption and removal based on graphene oxide functionalized with magnetic cyclodextrin

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Dongxue; Liu, Liangliang; Jiang, Xinyu; Yu, Jingang [College of Chemistry and Chemical Engineering, Central South University, Changsha 410083 (China); Chen, Xiaohong [Collaborative Innovation Center of Resource-conserving & Environment-friendly Society and Ecological Civilization, Changsha, 410083 (China); Chen, Xiaoqing, E-mail: xqchen@csu.edu.cn [College of Chemistry and Chemical Engineering, Central South University, Changsha 410083 (China); Collaborative Innovation Center of Resource-conserving & Environment-friendly Society and Ecological Civilization, Changsha, 410083 (China)

    2015-02-28

    Highlights: • Magnetic β-cyclodextrin-graphene oxide (MCG) show high adsorption capacity. • The maximum adsorption capacity was 1102.58 mg/g at 45 °C and pH 8. • MCG can be easily and fast extracted from water by magnetic attraction. • Removal rate of MCG could reach 98% after three times of adsorption. • Adsorption capacity of MCG remained at 81% after five cycles. - Abstract: Recently, graphene oxide (GO) based magnetic nanocomposites have been widely used in an adsorption-based process for the removal of organic pollutants from the water system. In this study, magnetic β-cyclodextrin-graphene oxide nanocomposites (MCG) were synthesized according to covalent binding of magnetic β-cyclodextrin nanoparticles onto the GO surface and the as-made nanocomposites were successfully applied as adsorbents for the adsorption and removal of p-phenylenediamines (PPD). The composition and morphology of prepared materials were characterized by Fourier infrared spectrometry (FT-IR), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). Effects of pH, temperature, time and reusability on the adsorption of PPD were investigated, as well as the kinetics and isotherms parameters of the adsorbents were determined. The results indicated that the maximum adsorption capacity of MCG was 1102.58 mg/g at 45 °C and pH 8. The adsorption capacity remained at 81% after five cycles. Removal rate could reach 98% after three times of adsorption. The adsorption process with PPD was found that fitted pseudo-second-order kinetics equations and the Langmuir adsorption model. The results showed the MCG had a good adsorption ability to remove organic pollutants in wastewater.

  10. Adsorbent for p-phenylenediamine adsorption and removal based on graphene oxide functionalized with magnetic cyclodextrin

    International Nuclear Information System (INIS)

    Wang, Dongxue; Liu, Liangliang; Jiang, Xinyu; Yu, Jingang; Chen, Xiaohong; Chen, Xiaoqing

    2015-01-01

    Highlights: • Magnetic β-cyclodextrin-graphene oxide (MCG) show high adsorption capacity. • The maximum adsorption capacity was 1102.58 mg/g at 45 °C and pH 8. • MCG can be easily and fast extracted from water by magnetic attraction. • Removal rate of MCG could reach 98% after three times of adsorption. • Adsorption capacity of MCG remained at 81% after five cycles. - Abstract: Recently, graphene oxide (GO) based magnetic nanocomposites have been widely used in an adsorption-based process for the removal of organic pollutants from the water system. In this study, magnetic β-cyclodextrin-graphene oxide nanocomposites (MCG) were synthesized according to covalent binding of magnetic β-cyclodextrin nanoparticles onto the GO surface and the as-made nanocomposites were successfully applied as adsorbents for the adsorption and removal of p-phenylenediamines (PPD). The composition and morphology of prepared materials were characterized by Fourier infrared spectrometry (FT-IR), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). Effects of pH, temperature, time and reusability on the adsorption of PPD were investigated, as well as the kinetics and isotherms parameters of the adsorbents were determined. The results indicated that the maximum adsorption capacity of MCG was 1102.58 mg/g at 45 °C and pH 8. The adsorption capacity remained at 81% after five cycles. Removal rate could reach 98% after three times of adsorption. The adsorption process with PPD was found that fitted pseudo-second-order kinetics equations and the Langmuir adsorption model. The results showed the MCG had a good adsorption ability to remove organic pollutants in wastewater

  11. Detection of Rapid Atrial Arrhythmias in SQUID Magnetocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Woong; Kwon, Hyuk Chan; Kim, Ki Dam; Lee, Yong Ho; Kim, Jin Mok; Kim, In Seon; Lim, Hyun Kyoon; Park, Yong Ki [Biomagnetism Research, Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Kim, Doo Sang [Seoul Veterans Hospital, Seoul (Korea, Republic of); Lim, Seung Pyung [Chungnam National University Hospital, Daejeon (Korea, Republic of)

    2005-10-15

    We propose a method to measure atrial arrhythmias (AA) such as atrial fibrillation (Afb) and atrial flutter (Afl) with a SQUID magnetocardiograph (MCG) system. To detect AA is one of challenging topics in MCG. As the AA generally have irregular rhythm and atrio-ventricular conduction, the MCG signal cannot be improved by QRS averaging; therefore a SQUID MCG system having a high SNR is required to measure informative atrial excitation with a single scan. In the case of Afb, diminished f waves are much smaller than normal P waves because the sources are usually located on the posterior wall of the heart. In this study, we utilize an MCG system measuring tangential field components, which is known to be more sensitive to a deeper current source. The average noise spectral density of the whole system in a magnetic shielded room was 10 fT/Hz(a) 1 Hz and 5 fT/Hz(a) 100 Hz. We measured the MCG signals of patients with chronic Afb and Afl. Before the AA measurement, the comparison between the measurements in supine and prone positions for P waves has been conducted and the experiment gave a result that the supine position is more suitable to measure the atrial excitation. Therefore, the AA was measured in subject's supine position. Clinical potential of AA measurement in MCG is to find an aspect of a reentry circuit and to localize the abnormal stimulation noninvasively. To give useful information about the abnormal excitation, we have developed a method, separative synthetic aperture magnetometry (sSAM). The basic idea of sSAM is to visualize current source distribution corresponding to the atrial excitation, which are separated from the ventricular excitation and the Gaussian sensor noises. By using sSAM, we localized the source of an Afl successfully.

  12. A COMPARISON OF TWO DIFFERENT DOSES OF DEXMEDETOMIDINE INFUSION DURING MAINTENANCE OF GENERAL ANAESTHESIA IN PATIENTS UNDERGOING SPINE SURGERIES, FUNCTIONAL ENDOSCOPIC SINUS SURGERY AND MIDDLE EAR SURGERIES

    Directory of Open Access Journals (Sweden)

    Bijay

    2016-03-01

    Full Text Available BACKGROUND This study is undertaken to compare the hemodynamic effects and reduction in the doses of volatile anaesthetics and muscle relaxants using two different doses of dexmedetomidine infusion during maintenance of anaesthesia in spine, functional endoscopic sinus surgery and middle ear surgeries. METHODS Sixty patients are randomly divided into 2 groups of 30 each. After shifting to the operation theatre baseline vitals were recorded. Anesthesia induced with thiopentone sodium and intubation done with the help of succinylcholine and maintained with oxygen, nitrous oxide and isoflurane. After 1 min of intubation, maintenance infusion of dexmedetomidine (0.4 mcg/kg/hr and 0.7 mcg/kg/hr for patients allotted in 2 separate groups was started and stopped 15 min before end of surgery. Hemodynamic parameters and any reduction in the doses of volatile anaesthetics and muscle relaxants was noted. RESULTS Dexmedetomidine infusion (0.4 mcg/kg/hr and 0.7 mcg/kg/hr in both groups reduced the requirements of muscle relaxants and volatile anaesthetics. Hemodynamic stability was better in the group receiving 0.4 mcg/kg/hr. Patients receiving 0.7 mcg/kg/hr had higher incidence of hypotension, bradycardia and delayed emergence from anaesthesia. CONCLUSION Dexmedetomidine infusion at 0.4 mcg/kg/hr during maintenance of anaesthesia in spine surgery, FESS and middle ear surgery would be good option to reduce the requirements of volatile anaesthetics, muscle relaxants and for better hemodynamic stability. OBJECTIVE OF STUDY: Primary Objective To compare and evaluate the hemodynamic effects and reduction in requirements of volatile anaesthetics and muscle relaxants with two different doses of dexmedetomidine infusion during maintenance of general anaesthesia in patients undergoing spine, FESS and middle ear surgeries.

  13. Accumulation of Heavy Metals in People on a Gluten-Free Diet.

    Science.gov (United States)

    Raehsler, Stephanie L; Choung, Rok Seon; Marietta, Eric V; Murray, Joseph A

    2018-02-01

    Specific foods such as fish and rice have high concentrations of metals such as arsenic, mercury, lead, cadmium, and cobalt. Many gluten-free diets (GFDs) include these foods, so we evaluated whether a GFD was associated with increased metal bioaccumulation. We performed a population-based, cross-sectional study using data collected from the National Health and Nutrition Examination Survey (NHANES), from 2009 through 2012, collecting information on the diagnosis of celiac disease and adherence to a GFD. We tested NHANES blood samples to identify individuals with undiagnosed celiac disease, using assays for immunoglobulin A tissue transglutaminase followed by a confirmatory test for endomysial antibody. Among a total of 11,354 NHANES participants, celiac disease was diagnosed in 55 participants, based on test results or a reported clinical diagnosis. We collected NHANES survey data on blood levels of lead, mercury, and cadmium from subjects who were on a GFD (n = 115) and participants who were not on a GFD (n = 11,239). Levels of total arsenic in urine samples were available from 3901 subjects not following a GFD and 32 individuals following a GFD. NHANES participants were asked questions about fish and shellfish consumption. We performed multivariate logistic regression analyses to associate gluten-related conditions with blood concentrations of mercury, cadmium, and lead and urine concentration of total arsenic, adjusting for demographic characteristics, as well as for rice consumption or seafood intake. Geometric means were reported for urinary concentrations of total arsenic and blood concentrations of mercury, cadmium, and lead for demographic groups and subjects with gluten-related conditions (subjects without celiac disease who avoid gluten). Persons following a GFD had significantly increased total blood mercury levels (1.37 mcg/L) compared with persons not on a GFD (0.93 mcg/L) (P = .008), as well as increased blood levels of lead (1.42 vs 1.13 mcg/L; P

  14. Shape Modification and Size Classification of Microcrystalline Graphite Powder as Anode Material for Lithium-Ion Batteries

    Science.gov (United States)

    Wang, Cong; Gai, Guosheng; Yang, Yufen

    2018-03-01

    Natural microcrystalline graphite (MCG) composed of many crystallites is a promising new anode material for lithium-ion batteries (LiBs) and has received considerable attention from researchers. MCG with narrow particle size distribution and high sphericity exhibits excellent electrochemical performance. A nonaddition process to prepare natural MCG as a high-performance LiB anode material is described. First, raw MCG was broken into smaller particles using a pulverization system. Then, the particles were modified into near-spherical shape using a particle shape modification system. Finally, the particle size distribution was narrowed using a centrifugal rotor classification system. The products with uniform hemispherical shape and narrow size distribution had mean particle size of approximately 9 μm, 10 μm, 15 μm, and 20 μm. Additionally, the innovative pilot experimental process increased the product yield of the raw material. Finally, the electrochemical performance of the prepared MCG was tested, revealing high reversible capacity and good cyclability.

  15. Development and first evaluation of micro-calgrid: a 3-D, urban-canopy-scale photochemical model

    International Nuclear Information System (INIS)

    Stern, R.; Yamartino, R.J.

    2001-01-01

    This paper details the development and first application of the MICRO-CALGRID (MCG), micro-scale photochemical model. The MCG model treats individual buildings as obstacles with impenetrable surfaces, rather than as roughness elements; is driven by the flow and turbulence fields generated by the MISKAM Navier-Stokes model, the emissions generated by the German MOBILEV model, and the concentration inflow boundary conditions generated by the urban-scale CALGRID model; includes a detailed treatment of vehicle-induced turbulence; and is equipped with three chemistry schemes (SAPRC-93, CB-4, and an analytic solution for Chapman cycle chemistry). The MCG model is exercised in both its 2-D and 3-D modes. Also described is a MCG application to a 5-day episode measured within a busy street canyon in Berlin, Germany. Concentrations of all measured pollutants (CO, NO, NO 2 , benzene, SO 2 and TSP) were well reproduced by the MCG model. NO 2 performance appeared adequate using the simpler analytic chemistry solution; however, inclusion of vehicle-induced turbulence was found to improve model performance statistics. (Author)

  16. Visualization of Morse connection graphs for topologically rich 2D vector fields.

    Science.gov (United States)

    Szymczak, Andrzej; Sipeki, Levente

    2013-12-01

    Recent advances in vector field topologymake it possible to compute its multi-scale graph representations for autonomous 2D vector fields in a robust and efficient manner. One of these representations is a Morse Connection Graph (MCG), a directed graph whose nodes correspond to Morse sets, generalizing stationary points and periodic trajectories, and arcs - to trajectories connecting them. While being useful for simple vector fields, the MCG can be hard to comprehend for topologically rich vector fields, containing a large number of features. This paper describes a visual representation of the MCG, inspired by previous work on graph visualization. Our approach aims to preserve the spatial relationships between the MCG arcs and nodes and highlight the coherent behavior of connecting trajectories. Using simulations of ocean flow, we show that it can provide useful information on the flow structure. This paper focuses specifically on MCGs computed for piecewise constant (PC) vector fields. In particular, we describe extensions of the PC framework that make it more flexible and better suited for analysis of data on complex shaped domains with a boundary. We also describe a topology simplification scheme that makes our MCG visualizations less ambiguous. Despite the focus on the PC framework, our approach could also be applied to graph representations or topological skeletons computed using different methods.

  17. Evaluation of anti-microbial activity of spore powder of Ganoderma lucidum on clinical isolates of Prevotella intermedia: A pilot study

    Directory of Open Access Journals (Sweden)

    Ranganath N Nayak

    2015-01-01

    Full Text Available Aim: This study aimed at evaluating the anti-microbial activity of spore powder of Ganoderma lucidum on Prevotella intermedia isolated from subgingival plaque from chronic periodontitis patients. Settings and Design: Written informed consent was obtained from each subject enrolled in the study. The Institutional Ethics Committee granted the ethical clearance for the study. Materials and Methods: This study included 20 patients diagnosed with chronic periodontitis. Pooled subgingival plaque samples were collected using sterile curettes from the deepest sites of periodontal pockets. The collected samples were then transported in 1 mL of reduced transport fluid. The organisms were cultured and confirmed. These organisms were then used for minimum inhibitory concentration (MIC procedure. Statistical Analysis: Mean of the MIC value obtained was calculated. Results: Thirteen out of the 20 clinical samples were tested that showed sensitivity at various concentrations. Five samples showed sensitivity at all concentrations. Twelve samples showed sensitivity at 8 mcg/ml. Eleven samples showed sensitivity at 4 mcg/ml, 8 samples showed sensitivity at 2 mcg/ml, and 5 samples showed sensitivity even at 1 mcg/ml. Mean MIC value of G. lucidum spore powder for P. intermedia obtained was 3.62 mcg/ml. Conclusion: G. lucidum with its multipotential bioactivity could be used as an anti-microbial, in conjunction with conventional therapy in periodontal disease.

  18. Characteristic parameters of electromagnetic signals from a human heart system

    International Nuclear Information System (INIS)

    Liu Xin-Yuan; Wang Yin; Zhang Su-Ming; Gao Hong-Lei; Pei Liu-Qing; Dai Yuan-Dong

    2011-01-01

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG) and magnetocardiography (MCG) are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired; the MCG data are captured using a high-T c radio frequency superconducting quantum interference device (HTc rf SQUIDs) and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency f z of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs) of ECG and MCG in the time—frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and f z for healthy subjects. We have postulated the following criterion: if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  19. Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes.

    Science.gov (United States)

    Anderson, Collin; MacKay, Mark

    2015-12-16

    Determine the stability of fentanyl 10 mcg/mL in 0.9% sodium chloride, fentanyl 10 mcg/mL in 5% dextrose, fentanyl 50 mcg/mL, hydromorphone 100 mcg/mL in 0.9% sodium chloride, ketamine 10 mg/mL, midazolam 0.4 mg/mL in 5% dextrose, midazolam 5 mg/mL, morphine 1 mg/mL in 0.9% sodium chloride, morphine 1 mg/mL in 5% dextrose, and pentobarbital 50 mg/mL when stored as single drug entities at room temperature in polypropylene syringes. Four 5 mL samples of each drug and concentration were prepared in 10 mL polypropylene syringes. The samples were stored at ambient room temperature in a locked cabinet. Triplicate determinations of drug concentration for each sample were performed initially, on day 50 or 51, and on day 100 using high-performance liquid chromatography with diode-array detection. With the exception of the hydromorphone 100 mcg/mL dilution, all compounds were found to contain greater than 95% of their initial concentration remaining at 100 days. Each sample remained clear and colorless when visually inspected.

  20. Role of Magnetocardiography in Emergency Room

    International Nuclear Information System (INIS)

    Kwon, H.; Kim, K.; Kim, J. M.; Lee, Y. H.; Kim, T. E.; Lim, H. K.; Park, Y. K.; Ko, Y. G.; Chung, N.

    2006-01-01

    In emergency rooms, patients with acute chest pain should be diagnosed as quickly as possible with higher diagnostic accuracy for an appropriate therapy to the patients with acute coronary syndrome or for avoiding unnecessary hospital admissions. At present, electrocardiography(ECG) and biochemical markers are generally used to detect myocardial infarction and coronary angiography is used as a gold standard to reveal the degree of narrowing of coronary artery. Magnetocardiography(MCG) has been proposed as a novel and non-invasive diagnostic tool fur the detection of cardiac electrical abnormality associated with myocardial ischemia. In this study, we examined whether the MCG can be used fur the detection of coronary artery disease(CAD) in patients, who were admitted to the emergency room with acute chest pain. MCG was recorded from 36 patients admitted to the emergency room with suspected acute coronary syndrome. The MCG recordings were obtained using a 64-channel SQUID MCG system in a magnetically shielded room. In result, presence of CAD could be found with a sensitivity of 88.2 % in patients with acute chest pain without 57 elevation in ECG, demonstrating a possible use in the emergency room to screen CAD patients.

  1. Evidence towards improved estimation of respiratory muscle effort from diaphragm mechanomyographic signals with cardiac vibration interference using sample entropy with fixed tolerance values.

    Directory of Open Access Journals (Sweden)

    Leonardo Sarlabous

    Full Text Available The analysis of amplitude parameters of the diaphragm mechanomyographic (MMGdi signal is a non-invasive technique to assess respiratory muscle effort and to detect and quantify the severity of respiratory muscle weakness. The amplitude of the MMGdi signal is usually evaluated using the average rectified value or the root mean square of the signal. However, these estimations are greatly affected by the presence of cardiac vibration or mechanocardiographic (MCG noise. In this study, we present a method for improving the estimation of the respiratory muscle effort from MMGdi signals that is robust to the presence of MCG. This method is based on the calculation of the sample entropy using fixed tolerance values (fSampEn, that is, with tolerance values that are not normalized by the local standard deviation of the window analyzed. The behavior of the fSampEn parameter was tested in synthesized mechanomyographic signals, with different ratios between the amplitude of the MCG and clean mechanomyographic components. As an example of application of this technique, the use of fSampEn was explored also in recorded MMGdi signals, with different inspiratory loads. The results with both synthetic and recorded signals indicate that the entropy parameter is less affected by the MCG noise, especially at low signal-to-noise ratios. Therefore, we believe that the proposed fSampEn parameter could improve estimates of respiratory muscle effort from MMGdi signals with the presence of MCG interference.

  2. A new magneto-cardiogram study using a vector model with a virtual heart and the boundary element method

    International Nuclear Information System (INIS)

    Zhang Chen; Lu Hong; Hua Ning; Tang Xue-Zheng; Tang Fa-Kuan; Shou Guo-Fa; Xia Ling; Ma Ping

    2013-01-01

    A cardiac vector model is presented and verified, and then the forward problem for cardiac magnetic fields and electric potential are discussed based on this model and the realistic human torso volume conductor model, including lungs. A torso—cardiac vector model is used for a 12-lead electrocardiographic (ECG) and magneto-cardiogram (MCG) simulation study by using the boundary element method (BEM). Also, we obtain the MCG wave picture using a compound four-channel HT c ·SQUID system in a magnetically shielded room. By comparing the simulated results and experimental results, we verify the cardiac vector model and then do a preliminary study of the forward problem of MCG and ECG. Therefore, the results show that the vector model is reasonable in cardiac electrophysiology. (general)

  3. Experimental study of mutagenous and mitosis modifying activity of silver nanoparticles

    Directory of Open Access Journals (Sweden)

    B. S. Kirbik

    2015-01-01

    Full Text Available Mutagenous and mitosis modifying impact of silver nanoparticles has been studied on outbred mice. Nanoparticles were of round shape with dimensions of 5-50 nm, size of generated organic shell of 2-5 nm, the quantity in 1 mcm3 makes 120-270. Metaphasic analysis of mice bone marrow cells was used as a testing technique. The frequency of chromosome aberrations and mitotic index of preparations were accounted. During single intraperitoneal administration of the agent in the dose of 250 mcg/kg the silver nanoparticles demonstrated mitosis stimulating activity. No mutagenous effect of silver nanoparticles by daily administration for 4 days of 25 mcg/kg and single administration in the dose of 250 mcg/kg has been registered, but there is statistically insignificant tendency of aberrant metaphases increase. Consequently silver nanoparticles in the investigated doses demonstrated no mutagenous activity and can be considered safe for mammalian cells.

  4. High-Tc SQUID gradiometer system for magnetocardiography in an unshielded environment

    International Nuclear Information System (INIS)

    Liao, S H; Hsu, S C; Lin, C C; Horng, H E; Chen, J C; Chen, M J; Wu, C H; Yang, H C

    2003-01-01

    We set up an electronic gradiometer for magnetocardiography (MCG) in an unshielded environment. The electronically balanced gradiometer consists of high-temperature radio-frequency superconducting quantum interference device (rf SQUID) magnetometers. The rf SQUID magnetometers are arranged to form the electronic first-order, four-vector gradiometer, or second-order gradiometer. The output of the MCG signal was filtered by a band pass (1-30 Hz) and power line filters. We can reduce the noise to ∼1 pT Hz -1/2 at 1 Hz for second-order or four-vector gradiometers. Two-dimensional MCG imaging is demonstrated. The results are discussed with data measured in the moderate magnetically shielded environment

  5. Routine clinical heart examinations using SQUID magnetocardiography at University of Tsukuba Hospital

    Science.gov (United States)

    Inaba, T.; Nakazawa, Y.; Yoshida, K.; Kato, Y.; Hattori, A.; Kimura, T.; Hoshi, T.; Ishizu, T.; Seo, Y.; Sato, A.; Sekiguchi, Y.; Nogami, A.; Watanabe, S.; Horigome, H.; Kawakami, Y.; Aonuma, K.

    2017-11-01

    A 64-channel Nb-based DC-SQUID magnetocardiography (MCG) system was installed at the University of Tsukuba Hospital (UTH) in March 2007 after obtaining Japanese pharmaceutical approval and insurance reimbursement approval. In the period between 2008 and 2016, the total number of patients was 10 085. The heart diseases diagnosed in fetuses as well as adults are mainly atrial arrhythmia, abnormal repolarization, ventricular arrhythmia, and fetal arrhythmia. In most cases of insufficient diagnostic accuracy with electrocardiography, SQUID MCG precisely revealed these heart diseases as an abnormal electrical current distribution. Based on success in routine examinations, SQUID MCG is now an indispensable clinical instrument with diagnostic software tuned up during routine use at UTH.

  6. Analysis of genetic diversity of Sclerotinia sclerotiorum from eggplant by mycelial compatibility, random amplification of polymorphic DNA (RAPD and simple sequence repeat (SSR analyses

    Directory of Open Access Journals (Sweden)

    Fatih Mehmet Tok

    2016-09-01

    Full Text Available The genetic diversity and pathogenicity/virulence among 60 eggplant Sclerotinia sclerotiorum isolates collected from six different geographic regions of Turkey were analysed using mycelial compatibility groupings (MCGs, random amplified polymorphic DNA (RAPD and simple sequence repeat (SSR polymorphism. By MCG tests, the isolates were classified into 22 groups. Out of 22 MCGs, 36% were represented each by a single isolate. The isolates showed great variability for virulence regardless of MCG and geographic origin. Based on the results of RAPD and SSR analyses, 60 S. sclerotiorum isolates representing 22 MCGs were grouped in 2 and 3 distinct clusters, respectively. Analyses using RAPD and SSR markers illustrated that cluster groupings or genetic distance of S. sclerotiorum populations from eggplant were not distinctly relative to the MCG, geographical origin and virulence diversity. The patterns obtained revealed a high heterogeneity of genetic composition and suggested the occurrence of clonal and sexual reproduction of S. sclerotiorum on eggplant in the areas surveyed.

  7. Efficient morse decompositions of vector fields.

    Science.gov (United States)

    Chen, Guoning; Mischaikow, Konstantin; Laramee, Robert S; Zhang, Eugene

    2008-01-01

    Existing topology-based vector field analysis techniques rely on the ability to extract the individual trajectories such as fixed points, periodic orbits, and separatrices that are sensitive to noise and errors introduced by simulation and interpolation. This can make such vector field analysis unsuitable for rigorous interpretations. We advocate the use of Morse decompositions, which are robust with respect to perturbations, to encode the topological structures of a vector field in the form of a directed graph, called a Morse connection graph (MCG). While an MCG exists for every vector field, it need not be unique. Previous techniques for computing MCG's, while fast, are overly conservative and usually results in MCG's that are too coarse to be useful for the applications. To address this issue, we present a new technique for performing Morse decomposition based on the concept of tau-maps, which typically provides finer MCG's than existing techniques. Furthermore, the choice of tau provides a natural tradeoff between the fineness of the MCG's and the computational costs. We provide efficient implementations of Morse decomposition based on tau-maps, which include the use of forward and backward mapping techniques and an adaptive approach in constructing better approximations of the images of the triangles in the meshes used for simulation.. Furthermore, we propose the use of spatial tau-maps in addition to the original temporal tau-maps. These techniques provide additional trade-offs between the quality of the MCGs and the speed of computation. We demonstrate the utility of our technique with various examples in the plane and on surfaces including engine simulation data sets.

  8. Neuroanatomy and sex differences of the lordosis-inhibiting system in the lateral septum

    Science.gov (United States)

    Tsukahara, Shinji; Kanaya, Moeko; Yamanouchi, Korehito

    2014-01-01

    Female sexual behavior in rodents, termed lordosis, is controlled by facilitatory and inhibitory systems in the brain. It has been well demonstrated that a neural pathway from the ventromedial hypothalamic nucleus (VMN) to the midbrain central gray (MCG) is essential for facilitatory regulation of lordosis. The neural pathway from the arcuate nucleus to the VMN, via the medial preoptic nucleus, in female rats mediates transient suppression of lordosis, until female sexual receptivity is induced. In addition to this pathway, other regions are involved in inhibitory regulation of lordosis in female rats. The lordosis-inhibiting systems exist not only in the female brain but also in the male brain. The systems contribute to suppression of heterotypical sexual behavior in male rats, although they have the potential ability to display lordosis. The lateral septum (LS) exerts an inhibitory influence on lordosis in both female and male rats. This review focuses on the neuroanatomy and sex differences of the lordosis-inhibiting system in the LS. The LS functionally and anatomically links to the MCG to exert suppression of lordosis. Neurons of the intermediate part of the LS (LSi) serve as lordosis-inhibiting neurons and project axons to the MCG. The LSi-MCG neural connection is sexually dimorphic, and formation of the male-like LSi-MCG neural connection is affected by aromatized testosterone originating from the testes in the postnatal period. The sexually dimorphic LSi-MCG neural connection may reflect the morphological basis of sex differences in the inhibitory regulation of lordosis in rats. PMID:25278832

  9. Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS.

    Directory of Open Access Journals (Sweden)

    Lenka A Vodstrcil

    Full Text Available Azithromycin is recommended for the treatment of uncomplicated urogenital chlamydia infection although the standard 1gram dose sometimes fails to eradicate the infection (treatment failure. One hypothesis proposed for treatment failure has been insufficient levels of the antibiotic at the site of infection. We developed an assay using liquid chromatography and tandem mass spectrometry (LC-MS/MS to measure azithromycin concentration in high-vaginal swabs and monitor how concentration changes over time following routine azithromycin treatment.Azithromycin concentrations were measured in two groups of women either within the first 24h of taking a 1g dose (N = 11 or over 9 days (N = 10. Azithromycin concentrations were normalised to an internal standard (leucine enkephalin, and the bulk lipid species phosphatidylcholine [PC(34:1], using an Agilent 6490 triple quadrupole instrument in positive ionisation mode. The abundances of azithromycin, PC(34:1, and leu-enkephalin were determined by multiple reaction monitoring and absolute levels of azithromycin estimated using standard curves prepared on vaginal specimens.Vaginal azithromycin concentrations of women were rapidly obtained after 5h post-treatment (mean concentration = 1031mcg/mg of lipid, range = 173-2693mcg/mg. In women followed for 9 days, peak concentrations were highest after day 2 (mean concentration = 2206mcg/mg, range = 721-5791mcg/mg, and remained high for at least 9 days with a mean concentration of 384mcg/mg (range = 139-1024mcg/mg on day 9.Our study confirmed that a single 1g dose of azithromycin is rapidly absorbed and remains in the vagina at relatively high levels for at least a week, suggesting that poor antibiotic absorption is unlikely to be an explanation for treatment failure.

  10. Transient degradation of NF-κB proteins in macrophages after interaction with mast cell granules

    Directory of Open Access Journals (Sweden)

    Noriko Ito

    1998-01-01

    Full Text Available The exposure of the macrophage cell line, J774 to mast cell granules (MCG led to the form ation of altered nuclear transcription factor proteins (NFκBx, which had faster electrophoretic mobility than the p50 homodimer of NF-κB, but retained comparable DNA binding capacity. Antibodies to N-terminal peptides of p50, p52, p65 or c-Rel supershifted only a fraction of NF-κBx. Western blot analyses revealed that nuclear p65 and c-Rel were progressively degraded after exposure to MCG, whereas nuclear p50 appeared to be unaffected. In contrast, cytoplasmic p50, p65, c-Rel as well as IkBα remained intact after MCG treatment, although p52 was clearly degraded. In comparison to J774 cells, incubation of m ouse peritoneal macrophages with MCG resulted in more extensive alterations to NF-κB proteins. The alterations in NF-κB proteins did not affect the expression of inducible nitric oxide synthase (iNOS or TNF-α mRNA in J774 cells. These data indicate that exposure of J774 cells to MCG leads to generation of altered nuclear p52, p65 and c-Rel, which retain intact N-terminal peptides, specific oligonucleotide binding and transactivating activity. On the other hand, in peritoneal macrophages, MCG induce more extensive modifications to NF-κB proteins with associated inhibition of iNOS or TNF-α mRNA expression.

  11. UJI ZONA HAMBAT EKSTRAK DAUN PUTRI MALU (Mimosa pudica TERHADAP BAKTERI Staphylococcus aureus DAN Methicillin-resistant Staphylococcus aureus (MRSA SECARA IN VITRO

    Directory of Open Access Journals (Sweden)

    Nyoman Ririn Chandrika Sari

    2015-04-01

    Full Text Available Resistensi Staphylococcus aureus dan MRSA terhadap antibiotika spektrum luas mendorong berbagai penelitian untuk menemukan senyawa aktif yang sensitif dan efektif dalam menghambat pertumbuhan bakteri.Penelitian ini bertujuan untuk mengetahui efek penghambatan ekstrak daun putri malu (Mimosa pudica terhadap pertumbuhan bakteri Staphylococcus aureus dan MRSA.Penelitian terhadap aktivitas antimikrobial ekstrak daun putri malu dilakukan dengan metode agar difusi cakram dengan menggunakan metode Kirby-Bauer.Suspensi bakteri disesuaikan dengan standar kekeruhan Mc Farland 0.5. Biakan bakteri dalam cawan petri masing-masing diberikan 6 perlakuan, yaitu kontrol positif (amoxicillin atau vancomycin, kontrol negatif (alkohol, serta ekstrak daun putri malu dengan konsentrasi 25 mcg/ml, 50 mcg/ml, 75 mcg/ml dan 100 mcg/ml. Pertumbuhan Staphylococcus aureus dihambat secara signifikan oleh ekstrak daun putri malu, dengan efek inhibisi pada semua konsentrasi secara signifikan lebih baik dibandingkan dengan kontrol positif (p<0.05. Zona inhibisi Staphylococcus aureus pada konsentrasi 25 mcg/ml adalah 28.86 mm dan telah memenuhi kriteria sebagai antimikrobial sensitif berdasarkan Clinical and Laboratory Standard Institute (CLSI. Inhibisi pertumbuhan MRSA secara signifikan terjadi pada semua konsentrasi ekstrak daun putri malu dibandingkan dengan kontrol negatif (p=0.00. Zona inhibisi terbesar ditemukan pada konsentrasi 100 mcg/ml dengan diameter sebesar 14.16 mm dan memiliki efek antimikrobial sebanding dengan vancomycin dalam menghambat pertumbuhan MRSA (p=0.186. Hasil uji agar difusi cakram menunjukkan bahwa senyawa aktif dalam ekstrak daun putri malu memiliki aktivitas antimikrobial yang tinggi terhadap Staphylococcus aureus dan MRSA secara in vitro.

  12. Heterogeneity of FeNO response to inhaled steroid in asthmatic children

    DEFF Research Database (Denmark)

    Buchvald, F; Eiberg, H; Bisgaard, H

    2003-01-01

    asthma, well controlled on regular BUD 400 mcg daily: 20 children with normal FeNO and 20 with raised FeNO. FeNO, BHR and forced expiratory volume in 1 s improved significantly after BUD 1600 mcg (BUD1600). However, FeNO after ICS treatment exhibited a Gaussian distribution and FeNO was significantly...... raised in 15 children. Allergy and BHR, but none of the other independent variables under study were significantly related to FeNO after BUD1600. CONCLUSION: Exhaled nitric oxide exhibited a heterogeneous response to ICS in asthmatic schoolchildren. Allergy and BHR were driving FeNO level independently...

  13. [The effect of multiple administrations of GABA and bicuculline into the rat neostriatum on the realization of a food-acquisition habit].

    Science.gov (United States)

    Iakimovskiĭ, A F

    1996-01-01

    The effects of three-week daily intrastriatal GABA (45 mcg) and bicucullin (5 mcg) microinjections on operant performance in the Skinner's box were studied in rats. GABA was shown to facilitate the operant responses (the rate of lever pressings increased, spontaneous motor activity became optimized). Bicucullin produced the opposite effects, i.e., the operant skill practically disappeared at the second-third week of injections. The operant behaviour was substantially influences by such factors as neurosurgery trauma, narcosis, and injections as demonstrated in control experiments. The findings suggest the involvement of GABAergic neostriatal system in realization of conditioned motor alimentary behaviour.

  14. Application of squids in the Iwate create project

    International Nuclear Information System (INIS)

    Yoshizawa, M.; He, D.F.; Nakai, K.; Kobayashi, K.; Nakamura, Y.; Yaegashi, M.; Ito, M.; Yashiro, H.; Daibo, M.; Simizu, T.; Uchikawa, Y.; Noto, K.

    2005-01-01

    We have developed a 64-channel magnetocardiograph (MCG) system for the diagnosis of heart disease. The MCG is characterized by its display of a unique three-dimensional image of bio-currents flowing inside the human body. The outline of the heart can be displayed without use of MRI. A mobile SQUID-based non-distractive evaluation apparatus was realized by the active shielding technique. The system can offer information from beneath the surface of the specimen by using a saw-wave excitation method. This mobile technology enables us to inspect ferromagnetic materials, whose high magnetic field rules out the use of a conventional SQUID apparatus near them

  15. SQUID application research in Japan

    International Nuclear Information System (INIS)

    Itozaki, Hideo

    2003-01-01

    Japanese research activities using SQUIDs are reviewed in this paper. Low-T c SQUIDs are applied to multi-channel systems for magnetoencephalogram (MEG) and magnetocardiogram (MCG). High-T c SQUIDs are applied to MCG, nondestructive evaluation (NDE), SQUID microscopy, biological testing using fine magnetic markers, geological surveying, food inspection, large-scale integration (LSI) defect analysis and SQUID-NQR (nuclear quadrupole resonance). These applications of SQUIDs are being researched and developed actively and some of them are expected to be in the commercial market in the near future

  16. Effect of the Sensor Location on Magnetocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Hyun Kyoon; Kim, Ki Woong; Kwon, Hyuk Chan; Lee, Yong Ho [Korea Research Instituteof Standards and Science, Daejeon (Korea, Republic of)

    2008-10-15

    Magnetocardiography (MCG) is a non-contact, non-invasive, and harmless diagnostic tool to detect the abnormal electrical conductivities of the heart caused by the various coronary artery disease or cardiac muscular disease. The purpose of this study is to identify whether MCG signals and MCG parameter values vary depending on the location of sensor assembly. It will be an important reference for the standard measurement. Four healthy male subjects (33.3 {+-} 6.3 years) participated in this study. Basal recording was made at 20 mm apart from the chest surface. All subjects were requested to take a regular breathe while MCG was taken. The gap between the chest surface and the bottom of the sensor assembly was 20, 40, 60, and 80 mm. Recording was made using 64 channel MCG system (Axial type, first order gradiometer) developed by Korea Research Institute of Standards and Science (KRISS). After resting for two minutes in a supine position on the bed in magnetically shielded room, MCG were recorded for 30 s. As the sensor location is getting away from the chest surface signal, the amplitude of R and T wave peak decreases to 70% (at 40 mm gap), 50% (at 60 mm), and 37% (at 80 mm) of the reference strength measured (y = 1.3903e{sup {sub {sup 0.0169x}}}, R{sup 2} 0.99; where y=amplitude remained after reduction, x=distance between chest surface and sensor location). The regression equations may be used as a good reference to calculate how much strength will be decreased by the distance. In MCG parameters, most values of parameters were decreased as the gap was increased. As an example, the current moment at T-wave peak reduced to 52% (at 40 mm gap), 33% (at 60 mm), and 19% (at 80 mm). However, the difference caused by the gap could be reduced by considering the distance when the MCG parameters were calculated. The study results can be used as a useful reference to design the baseline and the sensor location.

  17. Comparison of four recombinant hepatitis B vaccines applied on an accelerated schedule in healthy adults.

    Science.gov (United States)

    Hernández-Bernal, Francisco; Aguilar-Betancourt, Arístides; Aljovin, Virginia; Arias, Gloria; Valenzuela, Carmen; de Alejo, Karen Pérez; Hernández, Karina; Oquendo, Orcilia; Figueredo, Niurka; Figueroa, Nelvis; Musacchio, Alexis; Véliz, Gloria; García, Elizeth; Mollineda, Alina D; Juvier, Ana Isabel; Trujillo, Janette; Delahanty, Aurora; Ortega, D; Cinza, Z; González, Verena L Muzio

    2011-10-01

    A post-marketing, double blind, randomised, controlled clinical trial to assess the immunogenicity and safety profiles of four commercially available recombinant hepatitis B vaccines was performed. The vaccines included in this study were Heberbiovac-HB (®) (Heber Biotec S.A., Havana, Cuba), Euvax-B (®) (LG Chemical Ltd., Seoul, Korea), Hepavax-Gene (®)   (Greencross Vaccine Corp., Seoul, Korea), and Engerix-B (®) (GlaxoSmithKline Biologicals, Rixensart, Belgium). Vaccines were administered intramuscularly to healthy adults in three 20mg doses at monthly intervals (0 - 1 -  2 months). Four hundred volunteers aged 18 to 45 years (average age, 35 years) non-reactive for serological markers of hepatitis B virus infection were vaccinated. Volunteers were randomly assigned (ratio 1:1:1:1) to one of the four treatment groups. The antibody response (anti-HBs) was assessed at days 60, 90 and 365 post-vaccination using a commercial kit. The four vaccines showed to be safe and highly immunogenic. Similar seroprotection rates (anti-HBs ≥10 IU/L) about one month after application of the second and third dose were obtained for Engerix-B (®) , Hepavax-Gene (®) , Euvax-B (®) , and Heberbiovac-HB (®) vaccines 96.7%, 96.6%, 100%, 100% and 98.8%, 89.5%, 100%, 100%, respectively.. Heberbiovac-HB (®) vaccine achieved significantly higher geometric mean antibody titers (GMT) and rate of good and  hyper-responders at all time-points post-vaccination. The GMT on day 365 after full vaccination was significantly reduced in all groups compared to day 90, although Heberbiovac-HB (®) showed the highest anti-HBs GMT and good-responders rate. The four vaccines were well tolerated and poorly reactogenic. No serious adverse events were observed. This study confirms an overall good immune response and rapid priming for the  four vaccines in the course of an accelerated schedule, with higher anti-HBs geometric mean concentrations and better responses for Heberbiovac-HB (®) . [WHO

  18. Efficacy of some antibacterial agents against Streptococcus mutans ...

    African Journals Online (AJOL)

    dr.ihsan alsaimary

    2012-11-01

    Nov 1, 2012 ... caries teeth of human subject (out patients of alshaheed qais specialized ... Concentration (MIC) (μg/ml or mcg/ml) by using Brain-Heart Infu- sion (Oxoid). ... levels of 5 X 104 CFU/ml or higher most of the surfaces of the teeth ...

  19. Beta-carotene blood test

    Science.gov (United States)

    The normal range is 50 to 300 mcg/dL or 0.93 to 5.59 micromol/L. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about ...

  20. Perineural versus intravenous clonidine as an adjuvant to Bupivacaine in supraclavicular Brachial plexus block

    Directory of Open Access Journals (Sweden)

    Vikram Bedi

    2017-07-01

    Conclusion: Addition of clonidine 2mcg/kg to 28 ml of 0.5% bupivacaine in brachial plexus blocks results in a faster onset, increased duration of block and longer postoperative pain relief when compared to bupivacaine alone. These advantages are not observed when the same dose of clonidine is injected intravenously.

  1. 48 CFR 252.245-7000 - Government-furnished mapping, charting, and geodesy property.

    Science.gov (United States)

    2010-10-01

    ... mapping, charting, and geodesy property. 252.245-7000 Section 252.245-7000 Federal Acquisition Regulations..., charting, and geodesy property. As prescribed in 245.107-70, use the following clause: Government-Furnished Mapping, Charting, and Geodesy Property (DEC 1991) (a) Definition—Mapping, charting, and geodesy (MC&G...

  2. Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.

    Science.gov (United States)

    Giaccone, Annie; Zuppa, Athena F; Sood, Beena; Cohen, Meryl S; O'Byrne, Michael L; Moorthy, Ganesh; Mathur, Amit; Kirpalani, Haresh

    2017-07-01

    Objective  To describe the pharmacokinetics and pharmacodynamics of milrinone in infants with persistent pulmonary hypertension of the newborn (PPHN) and to explore the impact of age on milrinone disposition. Design  Randomized, open label pilot study. Setting  Multicenter; level 3 and level 4 neonatal intensive care units. Patients  Six infants ≥34 weeks' gestational age and milrinone lactate in one of two dosing regimens: (1) low dose, 20 mcg/kg bolus followed by 0.2 mcg/kg/minute, and (2) standard dose, 50 mcg/kg bolus followed by 0.5 mcg/kg/minute. Measurements and Main Results  The final structural model was a two-compartment disposition model with interindividual variability estimated on clearance (CL). The estimated value of CL is 7.65 mL/minute/3.4 kg (3.05 mL/minute/kg). The addition of age improved the precision of the CL estimate, and CL increased with chronological age in days. The oxygenation index was highly variable within each participant and improved with time. There were no observed safety concerns in either dosing group. Conclusion  The CL of milrinone in newborns with PPHN is reduced and increases with age. In this pilot study, we did not see significant pharmacodynamic or safety effects associated with drug exposure. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  3. Influence of vitamin b-12 complex injection (eldervit-12) on ...

    African Journals Online (AJOL)

    Objectives: To assess the effect of vitamin B-12 complex injection on the nephrotoxicity of gentamicin. Design: Experimental study using a pre-validated model. Subject: Adult Swiss albino rats weighing 140-214g, Generic gentamicin sulphate injection and Vitamin B-12complex injection containing 2500mcg ...

  4. AVC-Proloog : Een effectevaluatie

    NARCIS (Netherlands)

    Leuw, Ed.; Brouwers, M.

    1995-01-01

    In het arrondissement Assen wordt sinds maart 1991 de 'AVC-proloog' uitgevoerd. Dit is een verkorte Alcohol Verkeer Cursus (AVC), bestemd voor alcohol-verkeersdelinquenten met een ademalcoholgehalte van niet meer dan 570 mcg. Het gaat dus om een in vergelijking met de gewone AVC's 'lichtere'

  5. Features of the microelement status in children with acute urticaria

    Directory of Open Access Journals (Sweden)

    G. E. Yalovega

    2016-01-01

    Full Text Available Background: The increase in the occurrence of allergic dermatoses, especially in young children, is one of the urgent problems of pediatrics. The development of allergic reactions may be caused by changes in microelements balance of the body. Objective: Our aim was to study the features of the microelement status in children with acute urticaria.Methods: A comparative study included patients with acute urticaria of varying severity and healthy children (I and IIA groups of health. Study of microelement was carried out in hair samples by X-ray analysis.Results: The study revealed lower content of zinc in hair in patients with urticaria (n = 40 (48 compared to 146 mcg/g in 23 children of control group, p < 0.001. It also revealed lower content of calcium (447 and 2428 mcg/g respectively; p = 0.001 as well as higher content of sulfur (33860 and 26447 mcg/g respectively; p = 0.001 and potassium (537 and 312 mcg/g respectively; p = 0.001. Differences in the iron, nickel, copper, and chlorine content in hair in comparable groups were not detected. There was no association of microelements content with a burdened hereditary allergologic anamnesis.Conclusion: Children with urticaria have dismicroelemntosis, characterized by a decrease in zinc and calcium content, and an increase in the concentration of sulfur and potassium.

  6. History of a Building Automation System.

    Science.gov (United States)

    Martin, Anthony A.

    1984-01-01

    Having successfully used computer control in the solar-heated and cooled Terraset School, the Fairfax County, VA, Public Schools are now computerizing all their facilities. This article discusses the configuration and use of a countywide control system, reasons for the project's success, and problems of facility automation. (MCG)

  7. Canada-India Reactor (CIR)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1960-12-15

    Design information on the Canada-India Reactor is presented. Data are given on reactor physics, the core, fuel elements, core heat transfer, control, reactor vessel, fluid flow, reflector and shielding, containment, cost estimates, and research facilities. Drawings of vertical and horizontal sections of the reactor and fluid flow are included. (M.C.G.)

  8. Folic acid in diet

    Science.gov (United States)

    ... regularly removed from the body through urine, so excess amounts do not build up in the body. You should not get more than 1000 mcg per day of folic acid. Using higher levels of folic acid can mask vitamin B12 deficiency.

  9. The role of selenium in the metabolism of 45Ca and 99Sr in the bones of hens

    International Nuclear Information System (INIS)

    Nowosad, R.

    1977-01-01

    Under experimental conditions it was stated that the application of selenium at the dose of 5 mcg per animal led to some disturbances in mineral metabolism in the skeletal system of hens. That was expressed by a decrease of ash content in died mass, a decrease of 45 Ca and 90 Sr in bones, and the diminished activity of calcium. (author)

  10. Effects of Baseline Selection on Magnetocardiography: P-Q and T-P Intervals

    International Nuclear Information System (INIS)

    Lim, Hyun Kyoon; Kwon, Hyuk Chan; Kim, Tae En; Lee, Yong Ho; Kim, Jin Mok; Kim, In Seon; Kim, Ki Woong; Park, Yong Ki

    2007-01-01

    The baseline selection is the first and important step to analyze magnetocardiography (MCG) parameters. There are no difficulties to select the baseline between P- and Q-wave peak (P-Q interval) of MCG wave recorded from healthy subjects because the P-Q intervals of the healthy subjects do not much vary. However, patients with ischemic heart disease often show an unstable P-Q interval which does not seem to be appropriate for the baseline. In this case, T-P interval is alternatively recommended for the baseline. However, there has been no study on the difference made by the baseline selection. In this study, we studied the effect of the different baseline selection. MCG data were analyzed from twenty healthy subjects and twenty one patients whose baselines were alternatively selected in the T-P interval for their inappropriate P-Q interval. Paired T-test was used to compare two set of data. Fifteen parameters derived from the R-wave peak, the T-wave peak, and the period, T max/3 ∼ T max were compared for the different baseline selection. As a result, most parameters did not show significant differences (p>0.05) except few parameters. Therefore, there will be no significant differences if anyone of two intervals were selected for the MCG baseline. However, for the consistent analysis, P-Q interval is strongly recommended for the baseline correction.

  11. Browse Title Index

    African Journals Online (AJOL)

    Items 601 - 650 of 2005 ... Vol 83, No 11 (2006):, Editorial: Multi drug resistant tuberculosis, Abstract PDF .... and Safety of 2-Hourly 20 MCG Oral Misoprostol Solution Compared to ... Vol 87, No 11 (2010), Effects of enforcement of the traffic act on ...

  12. MJZ VOL 37 NO 2.CDR

    African Journals Online (AJOL)

    MJZ

    mcg/kg/min) should not be used for renal protection. A large randomized trial and meta-analysis showed ... mechanical ventilation. - White cell count > 12,000/mm3 or. 10% ... DBP = diastolic blood pressure; SBP = systolic blood pressure. ALI = acute lung injury; ARDS = acute respiratory distress syndrome ...

  13. Paediatric cardiac anaesthesia in sickle cell disease: a case series

    African Journals Online (AJOL)

    Paediatric patients with SCD and congenital heart defects may require ... Patients with sickle cell disease (SCD) presenting for cardiac ... fluid, calculated according to body weight, was initiated. ... oxygen mixture and intravenous fentanyl (5–10 mcg/kg) and .... erythropoiesis, and in this way reduces HbS production.

  14. Phagocytosis of mast cell granules results in decreased macrophage superoxide production

    Directory of Open Access Journals (Sweden)

    Bobby A. Shah

    1995-01-01

    Full Text Available The mechanism by which phagocytosed mast cell granules (MCGs inhibit macrophage superoxide production has not been defined. In this study, rat peritoneal macrophages were co-incubated with either isolated intact MCGs or MCG-sonicate, and their respiratory burst capacity and morphology were studied. Co-incubation of macrophages with either intact MCGs or MCG-sonicate resulted in a dose-dependent inhibition of superoxide- mediated cytochrome c reduction. This inhibitory effect was evident within 5 min of incubation and with MCG-sonicate was completely reversed when macrophages were washed prior to activation with PMA. In the case of intact MCGs, the inhibitory effect was only partially reversed by washing after a prolonged co-incubation time. Electron microscopic analyses revealed that MCGs were rapidly phagocytosed by macrophages and were subsequently disintegrated within the phagolysosomes. Assay of MCGs for superoxide dismutase (SOD revealed the presence of significant activity of this enzyme. A comparison of normal macrophages and those containing phagocytosed MCGs did not reveal a significant difference in total SOD activity. It is speculated that, although there was no significant increase in total SOD activity in macrophages containing phagocytosed MCGs, the phagocytosed MCGs might cause a transient increase in SOD activity within the phagolysosomes. This transient rise in SOD results in scavenging of the newly generated superoxide. Alternatively, MCG inhibition of NADPH oxidase would explain the reported observations.

  15. Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation

    Directory of Open Access Journals (Sweden)

    Davide Cattano

    2012-01-01

    Full Text Available This study compared remifentanil and dexmedetomidine as awake fiberoptic intubation (AFOI anesthetics. Thirty-four adult ASA I-III patients were enrolled in a double-blinded randomized pilot study to receive remifentanil (REM or dexmedetomidine (DEX for sedation during AFOI (nasal and oral. Thirty patients completed the study and received 2 mg midazolam IV and topical anesthesia. The REM group received a loading dose of 0.75 mcg/kg followed by an infusion of 0.075 mcg/kg/min. The DEX group received a loading dose of 0.4 mcg/kg followed by an infusion of 0.7 mcg/kg/hr. Time to sedation, number of intubation attempts, Ramsay sedation scale (RSS score, bispectral index (BIS, and memory recall were recorded. All thirty patients were successfully intubated by AFOI (22 oral intubations/8 nasal. First attempt success rate with AFOI was higher in the REM group than the DEX group, 72% and 38% (P=0.02, respectively. The DEX group took longer to attain RSS of ≥3 and to achieve BIS <80, as compared to the REM group. Postloading dose verbal recall was poorer in the DEX group. Dexmedetomidine seems a useful adjunct for patients undergoing AFOI but is dependent on dosage and time. Further studies in the use of dexmedetomidine for AFOI are warranted.

  16. Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus

    NARCIS (Netherlands)

    M. van der Burg (Mirjam); B.H. Barendregt (Barbara); E.J. van Gastel-Mol (Ellen); T. Tümkaya (Talip); A.W. Langerak (Anton); J.J.M. van Dongen (Jacques)

    2002-01-01

    textabstractTwo polymorphisms of the human Ig(lambda) (IGL) locus have been described. The first polymorphism concerns a single, 2- or 3-fold amplification of 5.4 kb of DNA in the C(lambda)2-C(lambda)3 region. The second polymorphism is the Mcg(-)Ke(+)Oz(-) isotype, which has

  17. Free T4, Free T3, and Reverse T3 in Critically Ill, Thermally Injured Patients

    Science.gov (United States)

    1980-09-01

    with myxedema suggest that the pituitary was either suppressed by steroids or coma , that is, T, concentrations in a range of 0.25 mcg per other factors...tyrosine in patients with altered thyroid function. J. C(i. of tyrosine in thyrotoxicosis and myxedema . Metabolism, 20: Endocrinol., 24: 691, 1964. .384-391

  18. Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action

    DEFF Research Database (Denmark)

    Hansen, J E; Witzke, N M; Nielsen, C

    1990-01-01

    Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml...

  19. Elevated Voriconazole Level Associated With Hallucinations and Suicidal Ideation: A Case Report.

    Science.gov (United States)

    Jansen, Jeffrey W; Sen, Sumon K; Moenster, Ryan P

    2017-01-01

    Voriconazole, a broad-spectrum antifungal, has been associated with visual and auditory hallucinations. We report the case of patient being treated with voriconazole for pulmonary aspergillosis who developed visual hallucinations and new suicidal ideation with plan. Voriconazole troughs were supratherapeutic (9.0 mcg/mL) and the patient was positive for the CYP2C19*1/*2 allele.

  20. Hashimotos Thyroiditis with Coexistent Papillary Carcinoma and ...

    African Journals Online (AJOL)

    final diagnosis of HT coexisting with papillary carcinoma and primary NHL (B-cell lineage) was made. Levothyroxine was initiated at 300mcg/day and patient was treated with chemotherapy (R-CHOP regime). Patient tolerated the chemotherapy well and with 12 months of follow-up, no recurrence or metastasis was noted.

  1. A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    LENUS (Irish Health Repository)

    Brown, Catherine M

    2012-02-01

    Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 microg intramuscularly using a four-dose schedule at 0, 1, 2, and 12 months. Responses were (1) a titer >100 mIU\\/mL = patient immune, (2) a titer level 10-99 mIU\\/mL = give a booster dose and recheck level 2 months later, and (3) 0 <\\/= 10 mIU\\/mL = repeat vaccination course using a different vaccine, Engerix-B. We compared responder groups in terms of titer levels for each vaccine and variables including age, gender, serum albumin, parathyroid hormone (PTH), calcium, phosphate, hemoglobin, years on dialysis, and type of dialysis access. Of the 176 patients who received the first vaccine course, 71 patients achieved immunity, that is, 40% uptake for the first vaccine. Of the 105 who failed, 72 received the second vaccine with 46 responders, that is, 64% uptake for the second vaccine. Overall, 143 of the 176 patients who entered the vaccination program completed the protocol with 117 achieving immunity, representing an 82% success rate. The only variable overall to show significance in achieving seroconversion was serum albumin (p = 0.03). Using a two-vaccine protocol, hepatitis B vaccination response was high in our population of end-stage renal disease patients.

  2. Cationic lipid-formulated DNA vaccine against hepatitis B virus: immunogenicity of MIDGE-Th1 vectors encoding small and large surface antigen in comparison to a licensed protein vaccine.

    Directory of Open Access Journals (Sweden)

    Anne Endmann

    Full Text Available Currently marketed vaccines against hepatitis B virus (HBV based on the small (S hepatitis B surface antigen (HBsAg fail to induce a protective immune response in about 10% of vaccinees. DNA vaccination and the inclusion of PreS1 and PreS2 domains of HBsAg have been reported to represent feasible strategies to improve the efficacy of HBV vaccines. Here, we evaluated the immunogenicity of SAINT-18-formulated MIDGE-Th1 vectors encoding the S or the large (L protein of HBsAg in mice and pigs. In both animal models, vectors encoding the secretion-competent S protein induced stronger humoral responses than vectors encoding the L protein, which was shown to be retained mainly intracellularly despite the presence of a heterologous secretion signal. In pigs, SAINT-18-formulated MIDGE-Th1 vectors encoding the S protein elicited an immune response of the same magnitude as the licensed protein vaccine Engerix-B, with S protein-specific antibody levels significantly higher than those considered protective in humans, and lasting for at least six months after the third immunization. Thus, our results provide not only the proof of concept for the SAINT-18-formulated MIDGE-Th1 vector approach but also confirm that with a cationic-lipid formulation, a DNA vaccine at a relatively low dose can elicit an immune response similar to a human dose of an aluminum hydroxide-adjuvanted protein vaccine in large animals.

  3. A prospective study of hepatitis B vaccination - a comparison of responders versus nonresponders.

    LENUS (Irish Health Repository)

    Brown, Catherine M

    2011-01-01

    Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO, was given at a dose of 40 µg intramuscularly using a four-dose schedule at 0, 1, 2, and 12 months. Responses were (1) a titer >100 mIU\\/mL = patient immune, (2) a titer level 10-99 mIU\\/mL = give a booster dose and recheck level 2 months later, and (3) 0 ≤ 10 mIU\\/mL = repeat vaccination course using a different vaccine, Engerix-B. We compared responder groups in terms of titer levels for each vaccine and variables including age, gender, serum albumin, parathyroid hormone (PTH), calcium, phosphate, hemoglobin, years on dialysis, and type of dialysis access. Of the 176 patients who received the first vaccine course, 71 patients achieved immunity, that is, 40% uptake for the first vaccine. Of the 105 who failed, 72 received the second vaccine with 46 responders, that is, 64% uptake for the second vaccine. Overall, 143 of the 176 patients who entered the vaccination program completed the protocol with 117 achieving immunity, representing an 82% success rate. The only variable overall to show significance in achieving seroconversion was serum albumin (p = 0.03). Using a two-vaccine protocol, hepatitis B vaccination response was high in our population of end-stage renal disease patients.

  4. Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naïve healthy volunteers.

    Science.gov (United States)

    Rauck, Richard; Oh, D Alexander; Parikh, Neha; Koch, Christian; Singla, Neil; Yu, Jin; Nalamachu, Srinivas; Vetticaden, Santosh

    2017-11-01

    Fentanyl sublingual spray offers rapid pain relief in opioid-tolerant cancer patients, and may be useful in acute or post-operative pain. Both opioid-naïve and non-tolerant patients are likely to receive opioids in these settings. Understanding the relationship between systemic exposure of fentanyl sublingual spray and effects on respiratory function in opioid-naïve or non-tolerant populations is important to ensure patient safety. This study evaluated single-dose fentanyl sublingual spray in opioid-naïve participants. Participants were randomized to receive single-dose fentanyl sublingual spray (100, 200, 400, 600, 800 mcg) or fentanyl citrate IV in one of five cohorts. Dosing occurred following a 10-h fast, with fasting continuing for 4 h post-dose. Dose proportionality was assessed using analysis of variance and linear regression techniques. PK assessments and safety monitoring were performed through 24 h post-dose. Safety assessments, including adverse event (AE) monitoring, occurred from dosing through Day 7. Fifty participants (19-53 years) received fentanyl sublingual spray or fentanyl citrate IV. Mean maximum plasma concentrations were reached between 0.27-0.60 h post-dose for fentanyl sublingual spray. Peak (C max ) and total (AUC 0- t , AUC 0-∞ ) fentanyl exposures increased in a linear, but more than dose-proportional manner, with higher doses. The most common AEs were somnolence, nausea, and vomiting. All AEs were mild or moderate in severity. Doses at 400, 600, and 800 mcg were associated with nausea and vomiting, requiring pharmacologic intervention. Hypoxia episodes requiring nasal cannula oxygenation were observed with 600mcg and 800mcg doses. Overall, single-dose fentanyl sublingual spray (100-800 mcg) was generally well tolerated, with greater incidences of AEs (e.g. nausea, vomiting, hypoxia) at higher doses. Doses up to 200 mcg may be safely administered to healthy opioid-naïve individuals with routine monitoring; doses

  5. Developpement D'un Modele Climatique Regional: Fizr Simulation des Conditions de Janvier de la Cote Ouest Nord Americaine

    Science.gov (United States)

    Goyette, Stephane

    1995-11-01

    Le sujet de cette these concerne la modelisation numerique du climat regional. L'objectif principal de l'exercice est de developper un modele climatique regional ayant les capacites de simuler des phenomenes de meso-echelle spatiale. Notre domaine d'etude se situe sur la Cote Ouest nord americaine. Ce dernier a retenu notre attention a cause de la complexite du relief et de son controle sur le climat. Les raisons qui motivent cette etude sont multiples: d'une part, nous ne pouvons pas augmenter, en pratique, la faible resolution spatiale des modeles de la circulation generale de l'atmosphere (MCG) sans augmenter a outrance les couts d'integration et, d'autre part, la gestion de l'environnement exige de plus en plus de donnees climatiques regionales determinees avec une meilleure resolution spatiale. Jusqu'alors, les MCG constituaient les modeles les plus estimes pour leurs aptitudes a simuler le climat ainsi que les changements climatiques mondiaux. Toutefois, les phenomenes climatiques de fine echelle echappent encore aux MCG a cause de leur faible resolution spatiale. De plus, les repercussions socio-economiques des modifications possibles des climats sont etroitement liees a des phenomenes imperceptibles par les MCG actuels. Afin de circonvenir certains problemes inherents a la resolution, une approche pratique vise a prendre un domaine spatial limite d'un MCG et a y imbriquer un autre modele numerique possedant, lui, un maillage de haute resolution spatiale. Ce processus d'imbrication implique alors une nouvelle simulation numerique. Cette "retro-simulation" est guidee dans le domaine restreint a partir de pieces d'informations fournies par le MCG et forcee par des mecanismes pris en charge uniquement par le modele imbrique. Ainsi, afin de raffiner la precision spatiale des previsions climatiques de grande echelle, nous developpons ici un modele numerique appele FIZR, permettant d'obtenir de l'information climatique regionale valide a la fine echelle spatiale

  6. Hepatoprotective and antioxidant effects of single clove garlic against CCl4-induced hepatic damage in rabbits.

    Science.gov (United States)

    Naji, Khalid Mohammed; Al-Shaibani, Elham Shukri; Alhadi, Fatima A; Al-Soudi, Safa'a Abdulrzaq; D'souza, Myrene R

    2017-08-17

    The increase in demand and consumption of single clove garlic or 'Solo garlic' (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antioxidant activities, oxidant-scavenging efficiency and preventive effects of SCG (single clove garlic) and MCG (multi clove garlic) on CCl 4 -induced acute hepatotoxicity in male rabbits. For this purpose, rabbits were orally administered with 3 ml of CCl 4 /kg of body weight, followed by 0.8 g of MCG or SCG/kg twice a week for three successive weeks. Oxidative hepatotoxicity was then assessed. SCG extracts exhibited higher antioxidant capacity than the MCG extract. Scavenging ability of SCG showed significant (p garlic storage constituents varies with the number of cloves present. CCl 4 -induced hepatotoxicity demonstrated histological changes including severe damage in the structure of liver tissues which correlated well to oxidative stress levels. Simultaneously, administration of SCG resulted in a significant reduction of serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TB) levels in addition to improvement in some histological parameters. Low levels of lipid peroxidation (malondialdehyde, MDA) (p < 0.001), along with a huge reduction in peroxidase (POx) (p < 0.001) revealed protection against oxidative toxicity in the liver homogenate. Higher levels of catalase (CAT) (p < 0.001) and superoxide dismutase (SOD) (p < 0.05) when compared to the MCG test (TM) group indicates that removal of H 2 O 2 is based on CAT activity in SCG test (TS) group rather than the POx activity demonstrated in the former group. The present study indicates that SCG possesses more protective ability than MCG against CCl 4 -induced liver injury and might be an effective alternative medicine against acute oxidative liver toxicity.

  7. Assessment of individual dose utilization vs. physician prescribing recommendations for recombinant activated factor VII (rFVIIa) in paediatric and adult patients with congenital haemophilia and alloantibody inhibitors (CHwI): the Dosing Observational Study in Hemophilia (DOSE).

    Science.gov (United States)

    Gruppo, R A; Kessler, C M; Neufeld, E J; Cooper, D L

    2013-07-01

    Recent data from the Dosing Observational Study in Hemophilia diary study has described home treatment with recombinant activated factor VII (rFVIIa) in congenital haemophilia with inhibitors (CHwI). The current analysis compares prescribed and patient/caregiver-reported rFVIIa administration in paediatric and adult CHwI patients in this study. Patients with ≥ 4 bleeding episodes within a 3-month period prescribed rFVIIa as first-line therapy for bleeding episodes were eligible. Patients/caregivers completed a diary for ≥ 90 days or until the patient experienced four bleeds. Initial, total and mean rFVIIa doses reported for each bleeding episode were calculated and compared with the physician-prescribed doses. Of 52 enrolled patients (25 children; 27 adults), 39 (75%) completed the study. Children and adults had similar mean durations of bleeding episodes. Both patient groups were administered higher initial rFVIIa doses for joint bleeds than prescribed: median (range) 215.2 (74.1-400.0) mcg kg(-1) vs. 200.0 (61.0-270.0) mcg kg(-1) for children, and 231.3 (59.3-379.7) mcg kg(-1) vs. 123.0 (81.0-289.0) mcg kg(-1) for adults. The median infused dose for joint bleeds was higher in adults than children (175.2 vs. 148.0 mcg kg(-1) ), but children received significantly more doses per joint bleed than adults (median 6.5 vs. 3.0). The median total dose per joint bleed was higher in children than adults (1248.7 vs. 441.6). For children and adults, both initial and additional doses administered for bleeds were higher than prescribed. Children received higher total doses per bleed due to an increased number of infusions per bleed. © 2013 John Wiley & Sons Ltd.

  8. Antimicrobial effects of 14 Medicinal plant speices of Dashti in Bushehr province

    Directory of Open Access Journals (Sweden)

    Afshin Shirkani

    2014-04-01

    Full Text Available Background: Medicinal plants are used in treating diseases as low-risk, available and inexpensive natural materials with higher consumption by people comparing to synthetic antimicrobial drugs. Excessive use of antimicrobial drugs led to medicinal resistance against different antibiotics in most bacteria. Material and Methods: In this empirical experimental study, the antimicrobial effects of methanolic extracts of 14 medicinal plants species were examined comparing to conventional therapeutic antibiotics against standard bacterial strains. The plant species were collected from dashti of Bushehr province.The methanolic extract of the cultivations broths were prepared in different concentrations (0/25%, 0/5%, 1%, 2% and 4% dissolved in DMSO/ Methanolic solution and their antibacterial potency respected on the inhibition zone using the disc diffusion assay. Results: The maximum effects on Escherichia coli belonged to Arundo donax and the least effects belonged to Calotropis procera. The maximum effects on Staphylococcus aureus belonged to Lawsonia inermis and the least effects belonged to Calotropis procera. The maximum effects on Micrococcus luteus belonged to Phoeniex doctylifera and the least effects belonged to Oligomeris baccatus. The maximum effects on Klebsiella pneumonia belonged to mnocarpos decander and the least effects belonged Oligomeris baccatus. The maximum effects on pseudomonas aeroginosa belonged to Arundo donax. The maximum effects on Bacillus subtilis belonged to Astragalus arbusculinus. Conclusion: The antimicrobial effects of 4% methanolic extracts of Arundo donax were comparable to Cephalotin (30mcg, Piperacilin (30mcg and Amikacin (30mcg against Escherichia coli and pseudomonas aeroginosa. The antimicrobial effects of %4 extracts of Lawsonia inermis were similar to Amikacin (30mcg and Chloramphenicol (30mcg against Klebsiella penumoniae.

  9. Networks and their traffic in multiplayer games

    Directory of Open Access Journals (Sweden)

    Cristian Andrés Melo López

    2016-06-01

    Full Text Available Computer games called multiplayer real-time, or (MCG are at the forefront of the use of the possibilities of the network. Research on this subject have been made for military simulations, virtual reality systems, computer support teamwork, the solutions diverge on the problems posed by MCG. With this in mind, this document provides an overview of the four issues affecting networking at the MCG. First, network resources (bandwidth, latency and computing capacity, together with the technical limits within which the MCG must operate. Second, the distribution concepts include communication architectures (peer-to-peer, client / server, server / network, and data and control architectures (centralized, distributed and reproduced .Thirdly, scalability allows the MCG to adapt to changes in parameterization resources. Finally, security is intended to fend off the traps and vandalism, which are common in online games; to check traffic, particularly these games we decided to take the massively multiplayer game League of Legends, a scene corresponding to a situation of real life in a network of ADSL access network is deployed has been simulated by using NS2 Three variants of TCP, it means SACK TCP, New Reno TCP, and TCP Vegas, have been considered for the cross traffic. The results show that TCP Vegas is able to maintain a constant speed while racing against the game traffic, since it avoids the packet loss and the delays in the tail caused by high peaks, without increasing the size of the sender window. SACK TCP and TCP New Reno, on the other hand, tend to increase continuously the sender window size, which could allow a greater loss of packages and also to cause unwanted delays for the game traffic.

  10. Study on the thyroid function of thoroughbred horses by means of 'in vitro' 125I-T3 modified and 125I-T4 tests

    International Nuclear Information System (INIS)

    Martin, B.W. de

    1975-01-01

    Sera of 71 animals, divided in groups of males and females, in repose and after activity were studied. The method to establish the percentage of the 125 I-lyothyronine retention in resin (Test 125 I-T 3 or T 3 ) was modified by the use of 0.2 ml of serum on the resin column, after addition of the marked hormone. This modification served to prove that thoroughbred equines show binding of the I-lyothyronine to the serum four times reduced, indicating, therefore, that these animals have four times more ligation sites of triidothyronin saturation in the serum, when compared with the results obtained from human beings. The variance analysis applied to the T 3 Test showed no significant results at the 95% level as regards to activity. For the 71 animals, the author has found an average of 50.30% of the 125 I-Lyothyronine in resin retention, being the confidence interval for this group between 48.75% and 51.85% to a 95% confidence coefficient. Evaluating the results of the T 4 Test by means of the variance analysis, we noticed that the male and female groups in repose differed statistically from the groups after activity to a 95% confidence coefficient. The author has grouped the results of the T 4 Test of 32 equines, 18 males and 14 females, in repose, obtaining an average of 0.61 mcg and 0.51 mcg and 0.71 mcg T 4 /100 ml as confidence interval to a 95% confidence coefficient. We have listed 39 results of T 4 Test, being 23 males and 61 Females, after activity, obtaining an average of 2.01 mcg of thyroxin by 100 ml of serum and 1.72 mcg and 2.30 T 4 /100 ml as confidence interval to a 95% confidence coefficient

  11. Clonidine as an adjunct to intravenous regional anesthesia: A randomized, double-blind, placebo-controlled dose ranging study

    Directory of Open Access Journals (Sweden)

    Clarence S Ivie

    2011-01-01

    Full Text Available Background : The addition of clonidine to lidocaine intravenous regional anesthesia (IVRA has been previously reported to improve postoperative analgesia in patients undergoing upper extremity surgery. Our objective was to perform a dose ranging study in order to determine the optimal dose of clonidine used with lidocaine in IVRA. Design & Setting : We performed a double-blinded randomized placebo-controlled study with 60 patients scheduled for elective endoscopic carpal tunnel release under IVRA with 50 ml lidocaine 0.5%. University-affiliated outpatient surgery center. Data collected in operating rooms, recovery room, and by telephone after discharge from surgery center. Materials & Methods : Sixty adult ASA I or II patients undergoing outpatient endoscopic carpal tunnel release under intravenous regional anesthesia.Patients were randomized into five study groups receiving different doses of clonidine in addition to 50 ml 0.5% lidocaine in their IVRA. Group A received 0 mcg/kg, group B 0.25 mcg/kg, group C 0.5 mcg/kg, group D 1.0 mcg/kg and group E 1.5 mcg/kg of clonidine.Intraoperative fentanyl, recovery room pain scores, time to first postsurgical analgesic, total number of acetaminophen/codeine tablets consumed postsurgery, incidence of sedation, hypotension and bradycardia. Results & Conclusions : There was no benefit from any dose of clonidine compared to placebo. There were no clonidine-related side effects seen within the dose range studied. In short duration minor hand surgery, the addition of clonidine to lidocaine-based intravenous regional anesthesia provides no measurable benefit.

  12. Comparison of two methods for blood lead analysis in cattle: graphite-furnace atomic absorption spectrometry and LeadCare(R) II system.

    Science.gov (United States)

    Bischoff, Karyn; Gaskill, Cynthia; Erb, Hollis N; Ebel, Joseph G; Hillebrandt, Joseph

    2010-09-01

    The current study compared the LeadCare(R) II test kit system with graphite-furnace atomic absorption spectrometry for blood lead (Pb) analysis in 56 cattle accidentally exposed to Pb in the field. Blood Pb concentrations were determined by LeadCare II within 4 hr of collection and after 72 hr of refrigeration. Blood Pb concentrations were determined by atomic absorption spectrometry, and samples that were coagulated (n = 12) were homogenized before analysis. There was strong rank correlation (R(2) = 0.96) between atomic absorption and LeadCare II (within 4 hr of collection), and a conversion formula was determined for values within the observed range (3-91 mcg/dl, although few had values >40 mcg/dl). Median and mean blood pb concentrations for atomic absorption were 7.7 and 15.9 mcg/dl, respectively; for LeadCare II, medians were 5.2 mcg/dl at 4 hr and 4.9 mcg/dl at 72 hr, and means were 12.4 and 11.7, respectively. LeadCare II results at 4 hr strongly correlated with 72 hr results (R(2) = 0.96), but results at 72 hr were lower (P atomic absorption. Although there have been several articles that compared LeadCare with other analytical techniques, all were for the original system, not LeadCare II. The present study indicated that LeadCare II results correlated well with atomic absorption over a wide range of blood Pb concentrations and that refrigerating samples for up to 72 hr before LeadCare II analysis was acceptable for clinical purposes.

  13. A case study comparing Positive Deviance/Hearth vs. the traditional health/nutrition education (Mother Care Groups) approach to prevent MAM and rehabilitate underweight children in Soroti, Uganda

    International Nuclear Information System (INIS)

    Baik, Diane

    2014-01-01

    Full text: BACKGROUND: Globally, 52 million children under 5 are moderately/severely wasted. To date, Supplementary Feeding Program (SFP) has been most commonly used to address moderate acute malnutrition (MAM) (low weight-for-height) where food rations are distributed. However, recently, high levels of wasting are being found even in areas with food security. Thus, rather than creating a dependence on food aid, different approaches need to be explored to address the global burden of MAM. World Vision (WV) has been implementing Positive Deviance/Hearth (PDH) since 1999 and has now expanded to more than 40 countries. WV believes PDH is an effective sustainable rehabilitation program for underweight children (low weight-for-age). However, since 2012, WV began using PDH to also rehabilitate MAM children, especially in areas with food security and no treatment for children with acute malnutrition. PDH is a behaviour change program that aims to rehabilitate children in the context of their own homes, to sustain the rehabilitation and prevent future malnutrition using existing resources, local solutions, and a food-based approach. Internationally, to date, there are mixed results in the effectiveness of PDH and the traditional health and nutrition education program called, “Mother Care Groups” (MCG), in successfully improving the behaviours of caregivers and rehabilitating underweight children. As PDH was being implemented in Soroti, Uganda, it was assessed and compared to MCG. METHODS: A comparative case study – quasi-experimental design was used to compare the effectiveness of the two programs in improving the knowledge, behaviour and confidence levels of primary caregivers of malnourished children aged 6-36 months of age in child feeding, hygiene, caring, and health-seeking practices in Soroti, Uganda. If change was seen, the improvement in the nutritional status of malnourished children was also assessed. 64 caregivers with underweight children were included in

  14. In vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents Susceptibilidad in vitro de la forma levaduriforme de Paracoccidioides brasiliensis a los agentes antifungicos

    Directory of Open Access Journals (Sweden)

    Angela Restrepo

    1984-12-01

    Full Text Available A study was conducted to determine the susceptibility of P. brasiliensis yeast form to amphotericin B (A, ketoconazole (K, 5-fluorocytosine (5-FC and rifampin (R. The three isolates tested produced minimal inhibitory concentrations (MICs (mcg/ml in the following range: A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 and R: 40-80. The minimal fungicidal concentrations (MFC were several times higher than the corresponding MICs. Precise MFC for 5-FC were not obtained (> 500 mcg/ml. Combination of K plus A proved synergic, with the fractional inhibitory concentration (FIC indices revealing synergy when the drugs were combined at the 1 to 1 and 1 to 5 MIC ratios. R (40 mcg/ml appeared to antagonize K. These results indicate promise for the combined use of K plus A as a therapeutical regimen.Se realizó un estudio con el objeto de determinar la susceptibilidad de la fase levaduri-forme del P. brasiliensis a la Anfotericina B (A, el Ketoconazol (K, la 5-fluorocitosina (5-FC y la rifampicina. Las 3 cepas estudiadas tuvieron las siguientes concentraciones inhibitorias mínimas (MIC (mcg/ml A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 y R: 40-80. Las concentraciones fungicidas mínimas (MFC resultaron más altas que las MICs correspondientes. En el caso de la 5-FC no se obtuvo una cifra MFC precisa (> 500 mcg/ml. La combinación de K más A mostró ser sinérgica al combinarse las drogas en relación 1:1 y 1:5 de los MICs respectivos. R (40 mcg/ml se mostró antagonista del K. Los resultados indican que la combinación A + K pudiera constituir un adecuado régimen terapéutico en ciertos pacientes.

  15. Once-daily long-acting beta-agonists for chronic obstructive pulmonary disease: an indirect comparison of olodaterol and indacaterol

    Directory of Open Access Journals (Sweden)

    Roskell NS

    2014-07-01

    Full Text Available Neil S Roskell,1 Antonio Anzueto,2 Alan Hamilton,3 Bernd Disse,4 Karin Becker5 1Statistics, Bresmed Health Solutions Ltd, Sheffield, UK; 2School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA; 3Medical Department, Boehringer Ingelheim (Canada Ltd, Burlington, ON, Canada; 4Medical Department, Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany; 5Global Health Economics and Outcomes Research, Boehringer Ingelheim GmbH, Ingelheim am Rhein, Germany Purpose: In the absence of head-to-head clinical trials comparing the once-daily, long-acting beta2-agonists olodaterol and indacaterol for the treatment of chronic obstructive pulmonary disease (COPD, an indirect treatment comparison by systematic review and synthesis of the available clinical evidence was conducted. Methods: A systematic literature review of randomized, controlled clinical trials in patients with COPD was performed to evaluate the efficacy and safety of olodaterol and indacaterol. Network meta-analysis and adjusted indirect comparison methods were employed to evaluate treatment efficacy, using outcomes based on trough forced expiratory volume in 1 second (FEV1, Transition Dyspnea Index, St George’s Respiratory Questionnaire total score and response, rescue medication use, and proportion of patients with exacerbations. Results: Eighteen trials were identified for meta-analysis (eight, olodaterol; ten, indacaterol. Olodaterol trials included patients of all severities, whilst indacaterol trials excluded patients with very severe COPD. Concomitant maintenance bronchodilator use was allowed in most olodaterol trials, but not in indacaterol trials. When similarly designed trials/data were analyzed for change from baseline in trough FEV1 (liters, the following mean differences (95% confidence interval were observed: trials excluding concomitant bronchodilator: indacaterol 75 mcg versus olodaterol 5 mcg, –0.005 (–0.077 to 0.067, and indacaterol 150 mcg

  16. [Assessment of hypersensitivity to honey-bee venom in beekeepers by skin tests].

    Science.gov (United States)

    Becerril-Ángeles, Martín; Núñez-Velázquez, Marco; Marín-Martínez, Javier

    2013-01-01

    Beekeepers are exposed to frequent honey-bee stings, and have the risk to develop hypersensitivity to bee venom, but long-term exposure can induce immune tolerance in them. Up to 30% of beekeepers show positive skin tests with honey-bee venom. The prevalence of systemic reactions to bee stings in beekeepers is from 14% to 42%. To know the prevalence of hypersensitivity to honeybee venom in Mexican beekeepers and non-beekeepers by the use of skin tests. A group of 139 beekeepers and a group of 60 non-beekeeper volunteers had a history and physical related to age, sex, family and personal atopic history and time of exposure to bee stings. Both groups received intradermal skin tests with honey-bee venom, 0.1 mcg/mL and 1 mcg/mL, and histamine sulphate 0.1 mg/mL and Evans solution as controls. The skin tests results of both groups were compared by chi-squared test. Of the group of beekeepers, 116 were men (83%) and 23 women, average age was 39.3 years, had atopic family history 28% and personal atopy 13%, average time of exposure to bee stings was 10.9 years, skin tests with honey-bee venom were positive in 16.5% and 11% at 1 mcg/mL and 0.1 mcg/mL, respectively. In the non-beekeepers group venom skin tests were positive in 13.3% and 6.7% at 1 mcg/mL and 0.1 mcg/mL. We did not find significant differences between the two venom concentrations tested in both groups, neither in the number of positive skin tests between the two groups. We found hypersensivity to honey-bee venom slightly higher in the beekeepers than in the group apparently not exposed. Both honey-bee venom concentrations used did not show difference in the results of the skin tests. The similarity of skin tests positivity between both groups could be explained by immune tolerance due to continued exposure of beekeepers.

  17. THE EFFECTS OF CHRONIC LEAD POISONING ON THE VALUES OF HYPERTENSION IN CHILDREN

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    Zivkovic Jovan

    2014-12-01

    Full Text Available Introduction: During the treatment of Roma children from Kosovska Mitrovica suffering from chronic lead poisoning (which began in the second half of the last decade, hypertension has also been observed. The examination and treatment were conducted under the patronage of World Health Organization, Ministry of Health of the Republic of Serbia and local administration. Aim of this work is show correlation between lead levels in blood and hypertension in children. Materials and methods: Lead from capillary blood flow was measured by Lead care analyzer. Extracted blood from a vein measured lead level in the toxicological laboratory of the Institute „Karajovic“ Belgrade. The pressure was measured by standard devices with changeable cuffs and has been expressed in mmHg. Hypertension has been observed in 159 children. They were divided into four groups. First group: non-Roma children (n = 32 with blood lead level of up to 10 mcg/dl. Second group: Roma children (n = 31 with blood lead level of up to 10 mcg/dl. Third group: Roma children (n = 53 with blood lead levels of 10–45 mcg/dl. Fourth group: Roma children (n = 43 with blood lead levels more than 45 mcg/dl, with an average value of 61.6 mcg/dl. Results: There is a statistically significant difference in the elevation of systolic blood pressure between group (chi-square = 31,179; p < 0,001, the first (x = 107,2 mmHg and the fourth group (x =114,6 mmHg, the second (x = 104,5 mmHg and fourth group, third (x =106,4 mmHg and fourth group. There is a statistically significant difference in the elevation of diastolic blood pressure between group (chi-square = 32,028; p < 0,001, the first (x = 67,7 mmHg and the fourth group (x =73,4 mmHg, the second (x = 66 mmHg and third group (x = 69 mmHg, second and fourth group, third and fourth group of children. It is concluded that when the value of lead in the blood was higher its effect on blood pressure was more pronounced. Conclusion: Most children with

  18. Efeitos do propofol na resposta contrátil do miocárdio à dopamina e dobutamina: estudo experimental em corações isolados de ratos Effects of the propofol in the myocardial contractile response to dopamine and dobutamine in isolated rat's heart

    Directory of Open Access Journals (Sweden)

    José Carlos Dorsa Pontes

    1996-12-01

    Full Text Available OBJETIVO: Estudo experimental das ações farmacodinâmicas do propofol e sua interação com a dopamina e dobutamina em corações isolados de ratos. MÉTODO: Foram estudadas as variações da contratilidade miocárdica (dT/dt, em 30 corações isolados de ratos. Em todos os animais, após anestesia por inalação de éter, os corações foram excisados e perfundidos em sistema de Langendorff com solução de Krebs - Hensleit enriquecida com 95% O2 e 5% CO2, (pressão de 90 cm de H2O, temperatura constante de 37,0ºC ± 0,5ºC. Foram estudados 30 animais divididos em: Grupo I (controle - 10 corações perfundidos durante 11 minutos com solução de Krebs - Hensleit; Grupo II (dopamina-propofol-dopamina -10 corações onde foram administrados dopamina (50 mcg/ml e analisados os resultados nos 1º, 3º e 5º minutos e, posteriormente, propofol, (25 mcg/ml infundindo-se 1 minuto após, dopamina (50 mcg/ml e analisando-se os 1º, 3º e 5º minutos. Grupo III (dobutamina-propofol-dobutamina - diferiu do Grupo II pela substituição da dopamina por dobutamina (50 mcg/ml. RESULTADOS: No Grupo I observou-se que a dT/dt variou de 39,57 ± 3,97 (g.seg-1 a 39,37 ± 3,44 (g.seg-1 (p>0,05 no período estudado. No Grupo II observou-se que, após a administração de propofol e dopamina, a dT/dt em (g.seg-1 apresentou queda de 17,61% (p0,05 no 1º minuto; 3,62% (p>0,05 no 3º minuto e 3,08% (p>0,05 no 5º minuto, comparado à injeção isolada da dobutamina. CONCLUSÃO: O propofol (25 mcg/ml não alterou a resposta contrátil do miocárdio à dobutamina (50 mcg/ml; no entanto, inibiu a resposta esperada pela ação da dopamina (50 mcg/ml na contratilidade miocárdica.PURPOSE: Experimental investigation of the pharmacodynamic effects of propofol with and without simultaneous injections of dopamine or dobutamine in isolated hearts of rats. METHODS: In all animals under anaesthesia the hearts were removed and irrigated by a Krebs-Hensleit solution containing O2

  19. [Membranous nephropathy associated to autoimmune thyroiditis, chronic pancreatitis and suprarrenal insufficiency].

    Science.gov (United States)

    Merino, J L; Fernández Lucas, M; Teruel, J L; Valer, P; Moreira, V; Arambarri, M; Ortuño, J

    2004-01-01

    A 33 year old female was admitted to the hospital to study aedema and bocio, A nephrotic syndrome was diagnosed and the renal biopsy demonstrated membranous glomerulonephritis, stage II. She was also diagnosed of Hashimoto's autoinmmune thyroiditis: TSH (41.5 uUl/ml), T4 (0.07 ng/dl), antithyroglobuline (1/2560) and antimicrosome (1/6400). Four year latter she was diagnosed of autoinmmune pancreatitis, without evidence of diabetes mellitus or exocrine pancreatic insufficiency. Eight years latter she was diagnosed of primary autoimmune suprarrenal insufficiency: basal cortisol: 2.7 mcg/dl, post ACTH estimulated cortisol: 5.6 mcg/dl, antinuclear antibody (1/160) and antiparietal (1/320). We present a pluriglandular autoimmune syndrome with membranous glomerulonephritis, thyroiditis, pancreatitis and suprarrenal insufficiency. To the best of our knowledge this complex syndrome has not been previously described.

  20. Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus.

    Science.gov (United States)

    Bond, Aaron

    2006-07-01

    Exenatide is the first drug in the incretin mimetic class and is indicated for treatment of type 2 diabetes mellitus. Although structurally similar to the native glucagon-like peptide, this synthetic form has a much longer duration of action. Randomized trials have shown exenatide to be efficacious in improving glycemic control when combined with either metformin or a sulfonylurea. The dose is initially 5 mcg subcutaneously twice daily and may be titrated to 10 mcg subcutaneously twice daily to achieve better diabetes management. Nausea, vomiting, and diarrhea were the most common adverse events reported with exenatide therapy. Exenatide is not associated with hypoglycemia, which may provide advantages over adding insulin to a sulfonylurea or metformin.

  1. Formation of amyloid fibers by monomeric light chain variable domains.

    Science.gov (United States)

    Brumshtein, Boris; Esswein, Shannon R; Landau, Meytal; Ryan, Christopher M; Whitelegge, Julian P; Phillips, Martin L; Cascio, Duilio; Sawaya, Michael R; Eisenberg, David S

    2014-10-03

    Systemic light chain amyloidosis is a lethal disease characterized by excess immunoglobulin light chains and light chain fragments composed of variable domains, which aggregate into amyloid fibers. These fibers accumulate and damage organs. Some light chains induce formation of amyloid fibers, whereas others do not, making it unclear what distinguishes amyloid formers from non-formers. One mechanism by which sequence variation may reduce propensity to form amyloid fibers is by shifting the equilibrium toward an amyloid-resistant quaternary structure. Here we identify the monomeric form of the Mcg immunoglobulin light chain variable domain as the quaternary unit required for amyloid fiber assembly. Dimers of Mcg variable domains remain stable and soluble, yet become prone to assemble into amyloid fibers upon disassociation into monomers. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  2. Fetal source extraction from magnetocardiographic recordings by dependent component analysis

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Draulio B de [Department of Physics and Mathematics, FFCLRP, University of Sao Paulo, Ribeirao Preto, SP (Brazil); Barros, Allan Kardec [Department of Electrical Engineering, Federal University of Maranhao, Sao Luis, Maranhao (Brazil); Estombelo-Montesco, Carlos [Department of Physics and Mathematics, FFCLRP, University of Sao Paulo, Ribeirao Preto, SP (Brazil); Zhao, Hui [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Filho, A C Roque da Silva [Department of Physics and Mathematics, FFCLRP, University of Sao Paulo, Ribeirao Preto, SP (Brazil); Baffa, Oswaldo [Department of Physics and Mathematics, FFCLRP, University of Sao Paulo, Ribeirao Preto, SP (Brazil); Wakai, Ronald [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Ohnishi, Noboru [Department of Information Engineering, Nagoya University (Japan)

    2005-10-07

    Fetal magnetocardiography (fMCG) has been extensively reported in the literature as a non-invasive, prenatal technique that can be used to monitor various functions of the fetal heart. However, fMCG signals often have low signal-to-noise ratio (SNR) and are contaminated by strong interference from the mother's magnetocardiogram signal. A promising, efficient tool for extracting signals, even under low SNR conditions, is blind source separation (BSS), or independent component analysis (ICA). Herein we propose an algorithm based on a variation of ICA, where the signal of interest is extracted using a time delay obtained from an autocorrelation analysis. We model the system using autoregression, and identify the signal component of interest from the poles of the autocorrelation function. We show that the method is effective in removing the maternal signal, and is computationally efficient. We also compare our results to more established ICA methods, such as FastICA.

  3. Heart Failure Treated with Low-dose Milrinone in a Full-term Newborn

    Directory of Open Access Journals (Sweden)

    S. Šebková

    2012-01-01

    Full Text Available A term newborn with a hypocontractile myocardium complicating persistent pulmonary hypertension of the newborn was successfully treated with a low-dose phosphodiesterase III inhibitor milrinone. Echocardiography diagnosed heart failure with a left ventricular ejection fraction of 35% and a left ventricular shortening fraction of 18% and severe persistent pulmonary hypertension of the newborn with oxygenation index of 28. Milrinone was started at an initial dose of 50 mcg/kg, followed by continuous infusion of 0.20 mcg/kg/min. With lowdose milrinone oxygenation index decreased to 3 within 6 hours, left ventricular ejection fraction and left ventricular shortening fraction increased to 57%, and 30%, respectively. Low doses of milrinone might be promising in the treatment of heart failure and persistent pulmonary hypertension of the newborn in term newborns.

  4. Heart failure treated with low-dose milrinone in a full-term newborn.

    Science.gov (United States)

    Sebková, S; Tomek, V; Zemanová, P; Janota, J

    2012-01-01

    A term newborn with a hypocontractile myocardium complicating persistent pulmonary hypertension of the newborn was successfully treated with a low-dose phosphodiesterase III inhibitor milrinone. Echocardiography diagnosed heart failure with a left ventricular ejection fraction of 35% and a left ventricular shortening fraction of 18% and severe persistent pulmonary hypertension of the newborn with oxygenation index of 28. Milrinone was started at an initial dose of 50 mcg/kg, followed by continuous infusion of 0.20 mcg/kg/min. With lowdose milrinone oxygenation index decreased to 3 within 6 hours, left ventricular ejection fraction and left ventricular shortening fraction increased to 57%, and 30%, respectively. Low doses of milrinone might be promising in the treatment of heart failure and persistent pulmonary hypertension of the newborn in term newborns.

  5. NOTE: Impedance magnetocardiogram

    Science.gov (United States)

    Kandori, Akihiko; Miyashita, Tsuyoshi; Suzuki, Daisuke; Yokosawa, Koichi; Tsukada, Keiji

    2001-02-01

    We have developed an impedance magnetocardiogram (IMCG) system to detect the change of magnetic field corresponding to changes in blood volume in the heart. A low magnetic field from the electrical activity of the human heart - the so-called magnetocardiogram (MCG) - can be simultaneously detected by using this system. Because the mechanical and electrical functions in the heart can be monitored by non-invasive and non-contact measurements, it is easy to observe the cardiovascular functions from an accurate sensor position. This system uses a technique to demodulate induced current in a subject. A flux-locked circuit of a superconducting quantum interference device has a wide frequency range (above 1 MHz) because a constant current (40 kHz) is fed through the subject. It is shown for the first time that the system could measure IMCG signals at the same time as MCG signals.

  6. Atypical femur fractures associated with bisphosphonates: from prodrome to resolution

    Directory of Open Access Journals (Sweden)

    Braulio Sastre-Jala

    2015-10-01

    Full Text Available Atypical fractures related to the prolonged use of bisphosphonates are caused by low energy mechanisms and are characterized by oblique and transverse lines and frequent bilateralism. We present a clinical case of a patient who we believe illustrates, both in clinical and radiological aspects, the new definition of atypical femur fracture related to treatment using bisphosphonates treated conservatively and successfully with discharge and teriparatide 20 mcg/80 mcl s.c./24h. The appearance of painful symptoms in the upper thigh, especially if bilateral, in patients treated with bisphosphonates for long periods of time, makes it necessary to dismiss bone lesions that might otherwise suggest atypical fracture. In those cases where the fracture is incomplete, restoring bone metabolism through the administration of teriparatide 20 mcg/80 mcl s.c./24h could prevent displaced fractures.

  7. PRESENCE OF ENTEROCOCCI IN COW MILK AND THEIR ANTIBIOTIC RESISTANCE

    Directory of Open Access Journals (Sweden)

    Miroslav Kročko

    2010-05-01

    Full Text Available Enterococci represent an important part of contaminate microflora in raw milk and dairy products. They constitute significant part of nosocomial pathogens with a remarkable capacity of expressing resistance to several antimicrobial  agents. We aimed to assess occurrence and antibiotic resistance of enterococci in the raw milk samples and pasteurized milk samples. In this study total bacterial count, psychrotrophic count and count of enterococci were determine in raw milk cistern samples, storage tank milk samples and milk samples after pasteurization. A collection of 46 enterococcal isolates were identified and screened for their antibiotic resistance. Isolates of E. faecalis were dominant in raw milk samples (56.5 %. Sensitive to teicoplanine (30 mcg/disk were 97.9 % of enterococcal isolates and 15.2 % isolates were resistant to vankomycin (30 mcg/disk.  

  8. On compact galaxies in the UGC catalogue

    International Nuclear Information System (INIS)

    Kogoshvili, N.G.

    1980-01-01

    A problem of separation of compact galaxies in the UGC Catalogue is considered. Value of surface brightness equal to or less than 21sup(m) was used as compactness criterion from a square second of arc. 96 galaxies, which are brighter than 14sup(m)5 satisfy this criterion. Among compact galaxies discovered in the UGC Catalogue 7% are the Zwicky galaxies, 15% belong to the Markarian galaxies and 27% of galaxies are part of a galaxy list with high surface brightness. Considerable divergence in estimates of total share of compact galaxies in the B.A. Worontsov-Veljaminov Morphological Catalogue of Galaxies (MCG) and the UGC Catalogue is noted. This divergence results from systematical underestimation of visible sizes of compact galaxies in the MCG Catalogue as compared with the UGC Catalogue [ru

  9. Hypothyroidism: challenges when treating older adults.

    Science.gov (United States)

    Pearson, Tamera

    2013-01-01

    Hypothyroidism frequently affects older adults' general sense of health, their cognitive abilities, and quality of life. Management decisions regarding when to start treatment and at what dosage to begin medication are influenced by both laboratory values and patient symptoms. Although specific guidelines regarding management of hypothyroidism in older adults do not exist, general recommendations include initiating hormone replacement with levothyroxine (Levoxyl(®), Synthroid(®), and others) at 12.5 mcg to 25 mcg and titrating the dose slowly based on response at 6-week intervals. Multiple medications and certain foods can interact with levothyroxine; therefore, the best dosage time is when a person is fasting or 4 hours postprandial. Using a consistent brand-name drug for hormone replacement with levothyroxine is important due to variations in the active ingredient in generic formulations. Providers need to be aware of the prevalence of hypothyroidism and management issues when caring for older adults. Copyright 2013, SLACK Incorporated.

  10. Strategy for elimination of iodine deficiency in Belarus: evaluation of 10 years experience

    Directory of Open Access Journals (Sweden)

    V I Kachan

    2010-09-01

    Full Text Available Article presents results of implementation of successful program of elimination of iodine deficiency in Belarus. Government decree (2001 requires mandatory use of iodized salt in food industry and public catering. While retail trade of non-iodized salt is not prohibited, all foods shops must have iodized salt on sale. All these measures resulted in increase of iodized salt consumption: 94% of house-holds in Belarus were using iodized salt. Iodine nutrition of population also sig-nificantly improved: median urinary iodine levels in general population (school-children reached 169 mcg/l and in pregnant women – 224 mcg/l. Endemic goiter morbidity decreased significantly in children, adolescents and adults as well as frequency of transitory thyroid dysfunctions in newborns. Belarus experience in prevention of iodine deficiency can be used by other industrialized countries of Europe and rest of the world.

  11. Soroprevalência da hepatite B e avaliação da resposta imunológica à vacinação contra a hepatite B por via intramuscular e intradérmica em profissionais de um laboratório de saúde pública Hepatitis B seroprevalence and evaluation of immune response to hepatitis B vaccination using intramuscular and intradermal routes in public health laboratory employees

    Directory of Open Access Journals (Sweden)

    Regina Célia Moreira

    2007-10-01

    Full Text Available OBJETIVOS: Determinar a prevalência dos marcadores da hepatite B (HBsAg e anti-HBs e avaliar a resposta à vacinação contra hepatite B por via intradérmica (ID em profissionais de saúde que não responderam à vacinação por via intramuscular (IM. MÉTODO: Todos os funcionários do Instituto Adolfo Lutz (IAL foram convidados a participar do estudo. Amostras de soro foram colhidas no momento da administração da primeira dose de vacina (Engerix® B e o HBsAg e o anti-HBs foram pesquisados, utilizando-se kits comerciais (Laboratórios Abbott®. Aos funcionários que não responderam à vacinação convencional (três doses por via IM foram oferecidas doses de 5µg da mesma vacina por via ID. RESULTADOS: Foram envolvidos nesse estudo 404 funcionários do IAL, dos quais dois (0,5% eram HBsAg e 42 (10,5%, anti-HBs reagentes. Dos 360 voluntários com sorologia negativa, 316 (87,8% receberam três doses de vacina (IM e, desses, 259 colheram soros para avaliação pós-vacinal. Do total, 242 (93,4% apresentaram anticorpos acima de 10 UI/L após completarem o esquema inicial. Foram administradas duas doses de reforço, porém sete funcionários permaneceram sem resposta imunológica. A vacinação intradérmica foi realizada em cinco voluntários, e todos produziram anticorpos após a utilização dessa via de administração. CONCLUSÕES: A prevalência da hepatite B não foi maior nessa população do que na população geral. A vacinação por via intradérmica pode ser uma boa alternativa na imunização de pessoas que não respondem ao esquema convencional.OBJECTIVES: To determine the prevalence of HBsAg and anti-HBs and to evaluate the response of intradermal hepatitis vaccination in healthcare workers non-responsive to previous repeated intramuscular vaccination. MATERIAL AND METHOD: All of the employees from Instituto Adolfo Lutz were invited to participate on this study. Serum samples were obtained and HBsAg and anti-HBs were detected

  12. Soroepidemiologia para o virus da hepatite B (VHB em gestantes/parturientes e sua transmissão para recém-nascidos em Goiânia, GO

    Directory of Open Access Journals (Sweden)

    Divina das Dores P. Cardoso

    1996-08-01

    Full Text Available Foram coletadas, entre março de 1990 e julho de 1992, 1459 amostras sanguíneas de mulheres gestantes/parturientes na cidade de Goiânia-GO, objetivando detecção da infecção pelo vírus da hepatite B (VHB, através dos marcadores sorológicos AgHBs e anti-HBs. O percentual depositividade encontrado, pelo teste imunoenzimãtico, foi de 7,5%, sendo 0,5%para AgHBs e 7,0%para anti-HBs. A análise efetuada, considerando a faixa etária, mostra que 7 de 8 mulheres AgHBs-positivas pertenciam à faixa etária de até 30 anos, situação semelhante em relação ao anti-HBs(83/101. Das 8 mulheres positivas, 4 tiveram seus recém-nascidos submetidos a tratamento profilático com vacina (Engerix B e imunoglobulina humana anti-hepatite B (HBIG. Além disso, 3 dessas crianças foram analisadas sorologicamente, sendo que uma era AgHBs-positiva ao nascimento. Doença sexualmente transmissível e transfusão sanguínea foram fatores de risco que coirelacionaram significantemente com a infecção. Esses resultados parece-nos reforçar a indicação de triagem à infecção pelo vírus da hepatite B no período pré-natal, assim como a adoção de medidas imunoprofiláticas nas crianças nascidas de mães positivas.In order to detect hepatitis B vírus (HBV, 1459 serum samples from pregnant/parturient women were collected at two public hospitals in Goiânia, GO. These samples were tested by enzyme linked immunosorbent assay forHBsAg and anti-HBs. 109 (7.5% serum samples were positive. Eight (0.5% sera were positive for HBsAg and 101 (7.0% for anti-HBs. Viral positivity for both HBsAg and anti- HBs were observed in women which age ranged from 15 to 30 years. Four newborns from HBsAg positive mothers were submitted to the treatment with HBV vaccine (Engerix B and with hyperimmune gammaglobulin (HBIG - Abbott Laboratories - Brazil. Cord blood from one of the newborns was positive for HBsAg. A positive association was found between hepatitis B and sexually

  13. DMA Modern Programming Environment Study.

    Science.gov (United States)

    1980-01-01

    capabilities. The centers are becoming increasingly dependent upon the computer and digital data in the fulfillment of MC&G goals. Successful application...ftticrcsrccessors C140 by Herbert AlteroDigital Citmmuncaticns C141 0 Structuredl Design ’-:orkshocr by Ned Chapin KC 156o Digital Systems En17lrceriirg CC 139 o3...on a programming environment. The study, which resulted in production of a paper entitled An EXEC 8 Programming Support Libary , contends that most of

  14. Fetal motion estimation from noninvasive cardiac signal recordings.

    Science.gov (United States)

    Biglari, Hadis; Sameni, Reza

    2016-11-01

    Fetal motility is a widely accepted indicator of the well-being of a fetus. In previous research, it has be shown that fetal motion (FM) is coherent with fetal heart rate accelerations and an indicator for active/rest cycles of the fetus. The most common approach for FM and fetal heart rate (FHR) assessment is by Doppler ultrasound (DUS). While DUS is the most common approach for studying the mechanical activities of the heart, noninvasive fetal electrocardiogram (ECG) and magnetocardiogram (MCG) recording and processing techniques have been considered as a possible competitor (or complement) for the DUS. In this study, a fully automatic and robust framework is proposed for the extraction, ranking and alignment of fetal QRS-complexes from noninvasive fetal ECG/MCG. Using notions from subspace tracking, two measures, namely the actogram and rotatogram, are defined for fetal motion tracking. The method is applied to four fetal ECG/MCG databases, including twin MCG recordings. By defining a novel measure of causality, it is shown that there is significant coherency and causal relationship between the actogram/rotatogram and FHR accelerations/decelerations. Using this measure, it is shown that in many cases, the actogram and rotatogram precede the FHR variations, which supports the idea of motion-induced FHR accelerations/decelerations for these cases and raises attention for the non-motion-induced FHR variations, which can be associated to the fetal central nervous system developments. The results of this study can lead to novel perspectives of the fetal sympathetic and parasympathetic brain systems and future requirements of fetal cardiac monitoring.

  15. Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia

    OpenAIRE

    Ihnatko, Robert; Post, Claes; Blomqvist, Anders

    2013-01-01

    Background: Anorexia-cachexia is a common and severe cancer-related complication but the underlying mechanisms are largely unknown. Here, using a mouse model for tumour-induced anorexia-cachexia, we screened for proteins that are differentially expressed in the hypothalamus, the brain’s metabolic control centre. Methods: The hypothalamus of tumour-bearing mice with implanted methylcholanthrene-induced sarcoma (MCG 101) displaying anorexia and their sham-implanted pair-fed or free-fed litterma...

  16. COMPARISON OF MISOPROSTOL AND MISOPROSTOL WITH ISOSORBIDE MONONITRATE IN SECOND TRIMESTER TERMINATION OF PREGNANCY

    OpenAIRE

    Shanthi Sivakumar; Nalina. S; Rukkayal Fathima; Rekha Radha

    2016-01-01

    BACKGROUND To compare the efficacy and side effect profile of vaginal misoprostol versus misoprostol and isosorbide mononitrate in enhancing cervical ripening in second trimester pregnancy termination. METHODS It is a random clinical trial done in 100 patients for mid trimester termination of pregnancy (between 12 and 24 weeks of gestational age). They were divided into two groups: Group A Combination of 400 mcg of misoprostol and 40 mg of ISMN placed intravaginally. Repe...

  17. A COMPARATIVE CLINICAL STUDY BETWEEN IV ESMOLOL AND IV FENTANYL ON ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION

    Directory of Open Access Journals (Sweden)

    Abu Lais Mustaque

    2016-04-01

    Full Text Available INTRODUCTION Laryngoscopy and intubation is an integral part for providing general anaesthesia to patients undergoing various types of surgery. It also plays an important role in critical care units viz. for providing mechanical ventilation. It is a very essential tool in the hands of anaesthesiologist in maintaining airway. The present study is undertaken to determine and compare the efficacy of single bolus dose of IV esmolol 1 mg/kg and IV fentanyl 2 mcg/kg in attenuating the haemodynamic responses to laryngoscopy and tracheal intubation and to ascertain the effectiveness of esmolol hydrochloride and fentanyl citrate in suppressing sympathetic responses. MATERIAL & METHODS The study was conducted under the Department of Anaesthesiology and Critical Care, Assam Medical College and Hospital, Dibrugarh, during the period July 2013 to June 2014. For this purpose, 150 patients of either sex between 20-50 years of ASA I & II physical status were selected after obtaining informed and written consent and were divided into two groups namely, Group E receiving IV esmolol (1 mg/kg and Group F receiving IV fentanyl (2 mcg/kg. RESULTS Inj. fentanyl 2 mcg/kg IV administered 5 minutes before laryngoscopy and intubation was able to prevent adverse haemodynamic changes better than Inj. esmolol 1 mg/kg IV administered 3 minutes prior to laryngoscopy and intubation during elective surgeries under general anaesthesia. CONCLUSION Hence, from the findings of this study we can conclude that IV bolus dose of fentanyl 2 mcg/kg administered 5 minutes before laryngoscopy and intubation can attenuate the sympathetic response to laryngoscopy and intubation without any side effects of the drug in healthy patients undergoing elective surgeries under general anaesthesia.

  18. Prophylactic Granisetron Vs Pethidine for the Prevention of Postoperative Shivering: A Randomized Control Trial

    Directory of Open Access Journals (Sweden)

    Asif lqbal

    2009-01-01

    The three groups did not differ significantly regarding patient characteristics. The numbers of patients shivering on arrival in the recovery room at 15 minutes after operation were significantly less in Group P (7% and Group G (17% than in Group S (60%. Groups P and G differ significantly than in Group S (p0.05. The prophylactic use of granisetron (40mcg.kg -1 and pethidine(25mg intravenous were found to be effective in preventing postoperative shivering.

  19. Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein.

    Science.gov (United States)

    Bettler, Jodi; Zimmer, J Paul; Neuringer, Martha; DeRusso, Patricia A

    2010-02-01

    Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula. Preliminary data suggest there are differences in serum lutein concentrations between breastfed and formula-fed infants. To measure the serum lutein concentrations among infants fed human milk or formulas with and without added lutein. A prospective, double-masked trial was conducted in healthy term formula-fed infants (n = 26) randomized between 9 and 16 days of age to study formulas containing 20 (unfortified), 45, 120, and 225 mcg/l of lutein. A breastfed reference group was studied (n = 14) and milk samples were collected from their mothers. Primary outcome was serum lutein concentration at week 12. Geometric mean lutein concentration of human milk was 21.1 mcg/l (95% CI 14.9-30.0). At week 12, the human milk group had a sixfold higher geometric mean serum lutein (69.3 mcg/l; 95% CI 40.3-119) than the unfortified formula group (11.3 mcg/l; 95% CI 8.1-15.8). Mean serum lutein increased from baseline in each formula group except the unfortified group. Linear regression equation indicated breastfed infants had a greater increase in serum lutein (slope 3.7; P milk lutein than formula-fed infants (slope 0.9; P lutein concentrations than infants who consume formula unfortified with lutein. These data suggest approximately 4 times more lutein is needed in infant formula than in human milk to achieve similar serum lutein concentrations among breastfed and formula fed infants.

  20. A network meta-analysis of randomized controlled trials for comparing the effectiveness and safety profile of treatments with marketing authorization for relapsing multiple sclerosis.

    Science.gov (United States)

    Hadjigeorgiou, G M; Doxani, C; Miligkos, M; Ziakas, P; Bakalos, G; Papadimitriou, D; Mprotsis, T; Grigoriadis, N; Zintzaras, E

    2013-12-01

    The relative effectiveness and safety profile of the treatments with marketing authorization for relapsing multiple sclerosis (MS) are not well known because randomized controlled trials with head-to-head comparisons between these treatments do not exist. Thus, a network of multiple-treatments meta-analysis was performed using four clinical outcomes: 'patients free of relapse', 'patients without disease progression', 'patients without MRI progression' and 'patients with adverse events'. Randomized controlled trials (RCTs) on MS were systematically searched in PubMed and Cochrane Central Register of Controlled Trial. The network analysis performed pairwise comparisons between the marketed treatments (Betaferon 250mcg, Avonex 30mcg, Rebif 44mcg, Rebif 22mcg, Aubagio 7 mg, Aubagio 14 mg, Copaxone 20 mg, Tysabri 300 mg, Gilenya 0·5 mg and Novantrone 12 mg/m(2)) using direct and indirect analyses. The analysis included 48 articles, involving 20 455 patients with MS. The direct analysis showed better response for more than one outcome for Gilenya compared with Avonex ('patients free of relapse' and 'patients without MRI progression') and for Betaferon compared with Avonex ('patients without disease progression' and 'patients without MRI progression'). The indirect analysis indicated that Tysabri may have better relative effectiveness compared with the other treatments for two outcomes: 'patients free of relapse' and 'patients without MRI progression'. Regarding 'patients with adverse events', no data were available for all comparisons to make fair inferences. This was an attempt, for the first time, to compare the efficacy and safety profile of existing approved treatments for relapsing MS. Although some treatments have shown better response, the results of the network analysis should be interpreted with caution because of the lack of RCTs with head-to-head comparisons between treatments. © 2013 John Wiley & Sons Ltd.

  1. Severe Hypoglycemia due to Isolated ACTH Deficiency in Children: A New Case Report and Review of the Literature

    OpenAIRE

    Torchinsky, Michael Y.; Wineman, Robert; Moll, George W.

    2011-01-01

    Isolated ACTH deficiency causes life-threatening severe hypoglycemia. A 7-year-old girl with hypoglycemia due to this rare disorder is described. Our patient had undetectable plasma ACTH repeatedly and cortisol 0 mcg/dl before and after ACTH 1-24 stimulation. There was no evidence of other pituitary hormone deficiency. Glucocorticoid replacement therapy resulted in resolution of all symptoms and normalization of blood glucose. Previously published data on isolated ACTH deficiency in children ...

  2. Estudo da ação "in vitro" da Oxamniquine sobre bactérias do gênero Salmonella

    Directory of Open Access Journals (Sweden)

    Vicente Amato Neto

    1976-04-01

    Full Text Available Os autores estudaram a ação "in vitro" da oxamniquine sobre dez espécies de salmonelas. Verificaram que diluições de 1,56 a 400 mcg/ml não exerceram qualquer efeito no crescimento bacteriano. Estas observações têm implicações no tratamento da salmonelose de curso prolongado, assim como nos estudos da sua patogenia.

  3. Effect of Two Different Doses of Dexmedetomidine on Stress Response in Laparoscopic Pyeloplasty: A Randomized Prospective Controlled Study.

    Science.gov (United States)

    Shamim, Rafat; Srivastava, Shashi; Rastogi, Amit; Kishore, Kamal; Srivastava, Aneesh

    2017-01-01

    Clonidine, opioids, β-blockers, and dexmedetomidine have been tried to attenuate stress responses during laparoscopic surgery. We evaluated the efficacy of dexmedetomidine in two different doses in attenuating stress responses on patients undergoing laparoscopic pyeloplasty. Ninety patients were assigned to one of the three groups: Group A, Group B, and Group C. Group B received dexmedetomidine 1 mcg/kg as loading dose, followed by 0.7 mcg/kg/h for maintenance; Group C received dexmedetomidine 0.7 mcg/kg as a loading dose, followed by 0.5 mcg/kg/h for maintenance. Group A received normal saline. Stress responses were assessed by the variations in heart rate (HR), mean arterial pressure (MAP), blood glucose levels, and serum cortisol levels. One-way analysis of variance test was applied. Multiple comparisons between groups were done with post hoc Bonferroni test. The HR and MAP were found to be higher in Group A. The difference was statistically significant ( P < 0.05) during intubation, carbon dioxide insufflation, and extubation when compared with Groups B and C. Blood glucose levels at postintubation and at extubation were higher in Group A and statistically significant ( P < 0.05) when compared with Groups B and C. Serum cortisol levels at postintubation, during midsurgery, and 2 h after extubation were higher in Group A and statistically significant ( P < 0.05) when compared with Groups B and C. However, HR, MAP, blood glucose levels, and serum cortisol levels were similar in dexmedetomidine groups. Dexmedetomidine decreases stress response and provides good condition for maintenance of anesthesia. Dexmedetomidine when used in lower dose in Group C decreases stress response comparable to higher dose in Group B.

  4. Control strategies and cycling demands for Li-ion storage batteries in residential micro-cogeneration systems

    International Nuclear Information System (INIS)

    Darcovich, K.; Kenney, B.; MacNeil, D.D.; Armstrong, M.M.

    2015-01-01

    Highlights: • Canadian home energy system modeled with PV, ICE CHP, battery and power grid. • Battery function is modeled on fundamental electrochemical principles. • Techno-economics of control strategies assessed. • Impact of control strategies battery cycles is developed for wear analysis. • Non-monotonic nature of battery cycles with transient renewables is discussed. - Abstract: Energy storage units have become important components in residential micro-cogeneration (MCG) systems. As MCG systems are often connected to single residences or buildings in a wide variety of settings, they are frequently unique and highly customized. Lithium-ion batteries have recently gained some profile as energy storage units of choice, because of their good capacity, high efficiency, robustness and ability to meet the demands of typical residential electrical loads. In the present work, modeled scenarios are explored which examine the performance of a MCG system with an internal combustion engine, photovoltaic input and a Li-ion storage battery. An electricity demand profile from new data collected in Ottawa, Canada is used to provide a full year energy use context for the analyses. The demands placed on the battery are examined to assess the suitability of the battery size and performance, as well as control related functionalities which reveal significantly varying battery use, and led to a quantitative expression for equivalent cycles. The energy use simulations are derived from electrochemical fundamentals adapted for a larger battery pack. Simulation output provides the basis for techno-economic commentary on how to assess large-scale Li-ion batteries for effective electrical storage purposes in MCG systems, and the impact of the nature of the control strategy on the battery service life

  5. Cost-Effectiveness of Treatments for Relapsing Remitting Multiple Sclerosis: A French Societal Perspective.

    Directory of Open Access Journals (Sweden)

    Julie Chevalier

    Full Text Available The paper aimed to estimate the incremental cost-effectiveness ratio (ICER at the public published price for delayed-release dimethyl fumarate versus relevant Multiple Sclerosis disease-modifying therapies available in France in June 2015.The economic model was adapted to the French setting in accordance with the Haute Autorité de Santé guidelines using a model previously developed for NICE. A cohort of Relapsing Remitting Multiple Sclerosis patients was simulated over a 30-year time horizon. Twenty one health states were taken into account: Kurtzke Expanded Disability Status Scale (EDSS 0-9 for Relapsing Remitting Multiple Sclerosis patients, EDSS 0-9 for Secondary Progressive Multiple Sclerosis patients, and death. Estimates of relative treatment efficacy were determined using a mixed-treatment comparison. Probabilities of events were derived from the dimethyl fumarate pivotal clinical trials and the London Ontario Dataset. Costs and utilities were extracted from the published literature from both the payer and societal perspectives. Univariate and probabilistic sensitivity analyses were performed to assess the robustness of the model results.From both perspectives, dimethyl fumarate and interferon beta-1a (IFN beta-1a 44 mcg were the two optimal treatments, as the other treatments (IFN beta-1a 30 mcg, IFN beta-1b 250 mcg, teriflunomide, glatiramer acetate, fingolimod were dominated on the efficiency frontier. From the societal perspective, dimethyl fumarate versus IFN beta-1a 44 mcg incurred an incremental cost of €3,684 and an incremental quality-adjusted life year (QALY of 0.281, corresponding to an ICER of €13,110/QALY.Despite no reference threshold for France, dimethyl fumarate can be considered as a cost-effective option as it is on the efficiency frontier.

  6. Cost-Effectiveness of Treatments for Relapsing Remitting Multiple Sclerosis: A French Societal Perspective.

    Science.gov (United States)

    Chevalier, Julie; Chamoux, Catherine; Hammès, Florence; Chicoye, Annie

    2016-01-01

    The paper aimed to estimate the incremental cost-effectiveness ratio (ICER) at the public published price for delayed-release dimethyl fumarate versus relevant Multiple Sclerosis disease-modifying therapies available in France in June 2015. The economic model was adapted to the French setting in accordance with the Haute Autorité de Santé guidelines using a model previously developed for NICE. A cohort of Relapsing Remitting Multiple Sclerosis patients was simulated over a 30-year time horizon. Twenty one health states were taken into account: Kurtzke Expanded Disability Status Scale (EDSS) 0-9 for Relapsing Remitting Multiple Sclerosis patients, EDSS 0-9 for Secondary Progressive Multiple Sclerosis patients, and death. Estimates of relative treatment efficacy were determined using a mixed-treatment comparison. Probabilities of events were derived from the dimethyl fumarate pivotal clinical trials and the London Ontario Dataset. Costs and utilities were extracted from the published literature from both the payer and societal perspectives. Univariate and probabilistic sensitivity analyses were performed to assess the robustness of the model results. From both perspectives, dimethyl fumarate and interferon beta-1a (IFN beta-1a) 44 mcg were the two optimal treatments, as the other treatments (IFN beta-1a 30 mcg, IFN beta-1b 250 mcg, teriflunomide, glatiramer acetate, fingolimod) were dominated on the efficiency frontier. From the societal perspective, dimethyl fumarate versus IFN beta-1a 44 mcg incurred an incremental cost of €3,684 and an incremental quality-adjusted life year (QALY) of 0.281, corresponding to an ICER of €13,110/QALY. Despite no reference threshold for France, dimethyl fumarate can be considered as a cost-effective option as it is on the efficiency frontier.

  7. A comparison of the analgesic efficacy of transforaminal methylprednisolone alone and with low doses of clonidine in lumbo-sacral radiculopathy.

    Science.gov (United States)

    Tauheed, Nazia; Usmani, Hammad; Siddiqui, Anwar Hasan

    2014-01-01

    Although transforaminal epidural steroid injections under fluoroscopic guidance have become a common mode of treatment of lumbosacral radiculopathy due to herniated disc, the efficacy of steroid with low doses of clonidine has not been compared yet. Comparison of the analgesic efficacy of methylprednisolone alone and with low doses of clonidine for transforaminal injection in lumbosacral radiculopathy. A randomized, double-blind trial. This study was performed at the Pain Clinic under the Department of Anaesthesiology, Jawaharlal Nehru Medical College Hospital, Aligarh Muslim University, Aligarh, India. One hundred and eighty ASA grade I and II patients aged between 18 and 55 years were allocated into groups I, II and III to receive methylprednisolone 60 mg alone or methylprednisolone 60 mg with or without low doses of clonidine (0.5 mcg/kg or 1 mcg/kg) as transforaminal epidural injection. Pain relief and patient's satisfaction were evaluated with the global pain scale. Follow-up visits were advised at 1, 2, 4, 6 and 12 weeks and then at 6 months after injection. Associated complications were recorded. Maximum pain relief was observed at 2 weeks after injection in all the three groups, with no difference in complication rate among the three groups. The most common complication observed was paresthesia in the nerve distribution. Greater than 60% improvement in pain scores was seen in 40% of the patients in group I, 50% of the patients in group II and 75% of the patients in group III. This study is limited by the lack of a placebo group. Adding 1 mcg/kg clonidine to 60 mg methylprednisolone in transforaminal epidural injections provided better pain relief than 60 mg methylprednisolone with 0.5 mcg/kg clonidine or 60 mg methylprednisolone alone in patients suffering from lumbosacral radiculopathy, with practically no significant side-effects.

  8. Differentiating leucine incorporation of Archaea and Bacteria throughout the water column of the eastern Atlantic using metabolic inhibitors

    OpenAIRE

    Yokokawa, T.; Sintes, E.; de Corte, D.; Olbrich, K.; Herndl, G.J.

    2012-01-01

    The abundance (based on catalyzed reporter deposition-fluorescence in situ hybrid ization, CARD-FISH) and leucine incorporation rates of Archaea and Bacteria were determined throughout the water column in the eastern Atlantic. Bacteria dominated throughout the water column, although their contribution to total prokaryotic abundance in the bathypelagic layer (1000 to 4000 m depth) was lower than in the surface and mesopelagic layers (0 to 1000 m depth). While marine Crenarchaeota Group I (MCG ...

  9. Differentiating leucine incorporation of Archaea and Bacteria throughout the water column of the eastern Atlantic using metabolic inhibitors

    OpenAIRE

    Yokokawa, Taichi; Sintes, Eva; de Corte, Daniele; Olbrich, Kerstin; Herndl, Gerhard J.

    2012-01-01

    The abundance (based on catalyzed reporter deposition-fluorescence in situ hybrid ization, CARD-FISH) and leucine incorporation rates of Archaea and Bacteria were determined throughout the water column in the eastern Atlantic. Bacteria dominated throughout the water column, although their contribution to total prokaryotic abundance in the bathypelagic layer (1000 to 4000 m depth) was lower than in the surface and mesopelagic layers (0 to 1000 m depth). While marine Crenarchaeota Group I (MCG ...

  10. Severe refractory hypertension during shoulder arthroscopy

    Directory of Open Access Journals (Sweden)

    R O Abrons

    2016-01-01

    Full Text Available The use of epinephrine-containing saline irrigating solutions during arthroscopic shoulder surgery gained popularity after it was reported that the addition of epinephrine reduced bleeding and improved visualization without adverse cardiovascular effects. We share a case of a patient undergoing shoulder arthroscopy who received a standard intra-articular infusion of epinephrine-containing normal saline (1 mcg/mL and experienced severe hemodynamic consequences.

  11. Etravirine Pharmacokinetics In HIV-Infected Pregnant Women

    Directory of Open Access Journals (Sweden)

    Nikki Mulligan

    2016-08-01

    Full Text Available Background: The study goal was to describe etravirine pharmacokinetics during pregnancy and postpartum in HIV-infected women. Methods: IMPAACT P1026s and PANNA are on-going, nonrandomized, open-label, parallel-group, multi-center phase-IV prospective studies in HIV-infected pregnant women. Intensive steady-state 12 or 24 hour pharmacokinetic profiles were performed from 2nd trimester through postpartum. Etravirine was measured at two labs using validated ultra performance liquid chromatography (detection limits: 0.020 mcg/mL and 0.026 mcg/mL. Results: Fifteen women took etravirine 200 mg twice-daily dosing and one took 400 mg once-daily. Etravirine AUC0-12 was significantly higher in the 3rd trimester compared to paired postpartum data by 45% (median 8.3 mcg*hr/mL versus 5.7 mcg*hr/mL, p = 0.086. Etravirine apparent oral clearance was significantly lower in the 3rd trimester of pregnancy compared to paired postpartum data (median 24 L/h versus 35 L/h, p = 0.038. The median ratio of cord blood to maternal plasma concentration at delivery was 0.56 (range: 0.19 - 4.25 and no perinatal transmission occurred. Conclusion: Etravirine apparent oral clearance is reduced and exposure increased during the third trimester of pregnancy. Based on prior dose-ranging and safety data, no dose adjustment is necessary for maternal health but the effects of etravirine in utero are unknown. Maternal health and infant outcomes should be closely monitored until further infant safety data are available. The IMPAACT protocol P1026s and PANNA study are registered at ClinicalTrials.gov under NCT00042289 and NCT00825929.

  12. [Serologic response to a DNA recombinant vaccine against hepatitis B in natives of the Peruvian Amazonian jungle].

    Science.gov (United States)

    Colichón, A; Vildósola, H; Sjogren, M; Cantella, R; Rojas, C

    1990-01-01

    Large areas of the Amazon basin in Brazil, Colombia, Ecuador, and in the nonoriental region of the peruvian jungle have been found to be hyperendemic to Hepatitis B with high prevalence of asymptomatic carriers (11 to 25%) and, in more selected areas, Hepatitis Delta has been also reported. In the present report, we have studied 108 volunteers from six different Jivaroes communities living in a hyperendemic Hepatitis B area. They received 2 doses of DNA recombinant yeast derivated HBV vaccine. All the selected persons were HBsAb negatives, but many (80%) had antibodies to HBc. Following immunization schedule, 80% responded with the formation of HBsAb; a better seroconversion was achieved in those negatives to anticore IgG compared with those having HBcAb. We obtained 90% of seroconversion in spite of the fact that our vaccination schedule was prolonged up to 10 months from the one recommended by the manufacturer. The vaccination schedule 0,4, 14 months, and the schedule 0,4 months, had 76 and 29% of seroconversion, respectively. We want to point out three observations: 1) It is quite possible that many of the Anti-core positives, that did not respond to vaccination were carriers of HBsAg undetectable by the conventional EIA test carried out; 2) The seroconversion rate in these natives was low (up to six months after the vaccination schedule); and 3) Many of the HBcAb were false positives and many of them were recently infected. We conclude: A) It is highly important to assess the anti-HBs hyperendemic areas before attempting vaccinations; B) All persons negative to anti-HBs should be vaccinated in spite to anticore antibodies; C) Areas with difficult access could be vaccinated even until 10 months without affecting good results, and D) DNA recombinant vaccine (ENGERIX B) was well tolerated. No side effects were observed.

  13. Prevalência de hepatite B em parturientes e perfil sorológico perinatal

    Directory of Open Access Journals (Sweden)

    Arraes Luiz Cláudio

    2003-01-01

    Full Text Available OBJETIVOS: avaliar a prevalência do antígeno de superfície do vírus B da hepatite (HBsAg em parturientes internadas no Instituto Materno-Infantil de Pernambuco (IMIP, Recife-PE, e o perfil sorológico das positivas. MÉTODOS: este é estudo de secção de corte transversal prospectivo no qual foram utilizados os sistemas VIDAS e VIDAS HBs, respectivamente, para detecção e confirmação do HBsAg. As participantes foram selecionadas de forma aleatória. Nas pacientes HBsAg+, os outros marcadores sorológicos foram testados com o sistema automatizado AxSYM. Os recém-nascidos de mães HBsAg+ foram vacinados ao nascer com a vacina Engerix B. RESULTADOS: de um total de 1584, encontramos 9 (0,6% gestantes HBsAg positivas. Nenhuma delas apresentava anti-HBc IgM, sendo assim casos prevalentes. Em 1/9 (11,1% das gestantes havia presença do HBeAg isolado e em 4/9 (44,4%, deste antígeno e seu anticorpo correspondente, revelando os diferentes graus de risco de transmissão vertical da infecção. Com a exceção de dois recém-nascidos de um parto gemelar (um de baixo peso, todos apresentaram soroconversão para o anti-HBs com três doses da vacina. Os gemelares prematuros só mostraram soroconversão após a quarta dose da vacina. CONCLUSÕES: a prevalência da hepatite B em parturientes no IMIP é relativamente baixa e todas as pacientes detectadas então tinham a forma crônica da infecção.

  14. Morse Set Classification and Hierarchical Refinement Using Conley Index

    KAUST Repository

    Guoning Chen,; Qingqing Deng,; Szymczak, A.; Laramee, R. S.; Zhang, E.

    2012-01-01

    Morse decomposition provides a numerically stable topological representation of vector fields that is crucial for their rigorous interpretation. However, Morse decomposition is not unique, and its granularity directly impacts its computational cost. In this paper, we propose an automatic refinement scheme to construct the Morse Connection Graph (MCG) of a given vector field in a hierarchical fashion. Our framework allows a Morse set to be refined through a local update of the flow combinatorialization graph, as well as the connection regions between Morse sets. The computation is fast because the most expensive computation is concentrated on a small portion of the domain. Furthermore, the present work allows the generation of a topologically consistent hierarchy of MCGs, which cannot be obtained using a global method. The classification of the extracted Morse sets is a crucial step for the construction of the MCG, for which the Poincar index is inadequate. We make use of an upper bound for the Conley index, provided by the Betti numbers of an index pair for a translation along the flow, to classify the Morse sets. This upper bound is sufficiently accurate for Morse set classification and provides supportive information for the automatic refinement process. An improved visualization technique for MCG is developed to incorporate the Conley indices. Finally, we apply the proposed techniques to a number of synthetic and real-world simulation data to demonstrate their utility. © 2006 IEEE.

  15. Different Nebulized Budesonide Dosing Regimens in a Mouse Model of Chronic Asthma

    Directory of Open Access Journals (Sweden)

    Pınar Uysal

    2016-12-01

    Full Text Available Objective: The aim of this study was to compare the effectiveness of different inhaled steroid regimens on the lungs and their potential side effects on the bone tissues in chronic asthma model. Materials and Methods: Thirty-five specific pathogen-free BALB/c mice were divided into five groups. The mice in all of the study groups except the control group were sensitized with chicken egg albumin. After sensitization, the mice in group 2 were treated with saline modeling twice daily, the mice in group 3 were treated with 250 mcg of nebulized budesonide twice daily, the mice in group 4 were treated with 500 mcg of budesonide once daily, and the mice in group 5 were treated with 1000 mcg of budesonide every other day for the last 14 days of the challenge period. After challenge, the mice were sacrificed and lung and tibia samples were histologically examined. Results: Pulmonary parameters, including subepithelial smooth muscle thickness, goblet cell count, mast cell count and epithelial thickness, were the lowest in group 5 compared to other groups (p0.01. Conclusion: The beneficial effect on lung tissue was highest in the treatment group receiving budesonide every other day (group 5 and no further measureable side effects on bone mineralization were observed in this group compared with the other treatment groups. Every-other-day treatment application seems to be the most effective regimen in chronic asthma model.

  16. A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro.

    Science.gov (United States)

    Anderson, Mark L

    2005-01-01

    Inhibition of 5alpha-reductase has been reported to decrease the symptoms of benign prostate hyperplasia (BPH) and possibly inhibit or help treat prostate cancer. Saw Palmetto berry lipid extract (SPLE) is reported to inhibit 5alpha-reductase and decrease the clinical symptoms of BPH. Epidemiologic studies report that carotenoids such as lycopene may inhibit prostate cancer. In this investigation the effect of the carotenoid astaxanthin, and SPLE were examined for their effect on 5alpha-reductase inhibition as well as the growth of prostatic carcinoma cells in vitro. These studies support patent #6,277,417 B1. The results show astaxanthin demonstrated 98% inhibition of 5alpha-reductase at 300 microg/mL in vitro. Alphastat, the combination of astaxanthin and SPLE, showed a 20% greater inhibition of 5alpha-reductase than SPLE alone n vitro. A nine day treatment of prostatic carcinoma cells with astaxanthin in vitro produced a 24% decrease in growth at 0.1 mcg/mL and a 38% decrease at 0.01 mcg/mL. SPLE showed a 34% decrease at 0.1 mcg/mL. Low levels of carotenoid astaxanthin inhibit 5alpha-reductase and decrease the growth of human prostatic cancer cells in vitro. Astaxanthin added to SPLE shows greater inhibition of 5alpha-reductase than SPLE alone in vitro.

  17. Morse Set Classification and Hierarchical Refinement Using Conley Index

    KAUST Repository

    Guoning Chen,

    2012-05-01

    Morse decomposition provides a numerically stable topological representation of vector fields that is crucial for their rigorous interpretation. However, Morse decomposition is not unique, and its granularity directly impacts its computational cost. In this paper, we propose an automatic refinement scheme to construct the Morse Connection Graph (MCG) of a given vector field in a hierarchical fashion. Our framework allows a Morse set to be refined through a local update of the flow combinatorialization graph, as well as the connection regions between Morse sets. The computation is fast because the most expensive computation is concentrated on a small portion of the domain. Furthermore, the present work allows the generation of a topologically consistent hierarchy of MCGs, which cannot be obtained using a global method. The classification of the extracted Morse sets is a crucial step for the construction of the MCG, for which the Poincar index is inadequate. We make use of an upper bound for the Conley index, provided by the Betti numbers of an index pair for a translation along the flow, to classify the Morse sets. This upper bound is sufficiently accurate for Morse set classification and provides supportive information for the automatic refinement process. An improved visualization technique for MCG is developed to incorporate the Conley indices. Finally, we apply the proposed techniques to a number of synthetic and real-world simulation data to demonstrate their utility. © 2006 IEEE.

  18. Diagnosis of Coronary Artery Disease in Patients with Chest Pain by Means of Magnetocardiography

    International Nuclear Information System (INIS)

    Kwon, H.; Kim, K.; Kim, J. M.; Lee, Y. H.; Kim, T. E.; Lim, H. K.; Park, Y. K.; Ko, Y. G.; Chung, N.

    2006-01-01

    Magnetocardiography(MCG) has been proposed as a novel and non-invasive diagnostic tool for the detection of cardiac electrical abnormality associated with myocardial ischemia. In our previous study, we have proposed a new classification method of MCG parameters, based on the different populations of the parameters between coronary artery disease(CAD) patients, symptomatic patients and healthy volunteers. We used four parameters, representing the directional changes of the electrical activity in the period of an R-ST-T interval. In patients with chest pain and without ST-segment elevation, who were selected consecutively from all patients admitted to the hospital in 2004, the patients with CAD could be classified with a higher sensitivity than conventional methods, showing that the proposed method can be useful for the diagnosis of CAD with MCG. In this study, we examined the validity of the algorithm with the prior probability distribution in diagnosis of new patients admitted to the hospital in 2005. In the results, presence of CAD could be found with sensitivity and specificity of 81.3% and 71.4%, respectively, in patients with chest pain and non-diagnostic ECG findings

  19. Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial

    Directory of Open Access Journals (Sweden)

    Renu Sinha

    2016-01-01

    Full Text Available Aim. Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV in children undergoing elective strabismus surgery. Methods. A total of 136 children (1–15 years were included. Children received either granisetron (40 mcg/kg [group G] or combination of granisetron (40 mcg/kg and dexamethasone (150 mcg/kg [group GD]. Intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were assessed. PONV severity was assessed for first 24 hours and if score was >2, it was treated with metoclopramide. Postoperative analgesia was administered with intravenous fentanyl and ibuprofen. Results. The demographic profile, muscles operated, and fentanyl requirement were comparable. Complete response to PONV in first 24 hours was observed in 75% (51/68 of children in group G and 76.9% (50/65 of children in group GD, which was comparable statistically (p=0.96, Fisher exact test; OR 1.11, 95% CI 0.50, 2.46. Incidence of PONV between 0 and 24 hours was comparable. One child in group G required rescue antiemetic in first 24 hours and none of the children had severe PONV in group GD. There was no significant difference in incidence or severity of oculocardiac reflex. Conclusion. Dexamethasone did not increase efficacy of granisetron for prevention of PONV in elective pediatric strabismus surgery. Registration number of clinical trial was CTRI/2009/091/001000.

  20. POST OPERATIVE NAUSEA AND VOMITING PROPHYLAXIS: A COMPARATIVE STUDY OF GRANISETRON ALONE AND GRANISETRON PLUS DEXAMETHASONE AFTER ENT SURGERIES

    Directory of Open Access Journals (Sweden)

    Sridevi

    2015-10-01

    Full Text Available BACKGROUND: Postoperative nausea and vomiting is one of the most frequently occurring side effects affecting one third of the cases. Objective of the study was to compare the efficacy of Granisetron alone and Granisetronplus D examethasone in preventing post - operative nausea and vomiting after ENT surgeries. MATERIALS AND METHOD S: This randomized controlled trial was conducted at the Anaesthesia and ENT departments of Santhiram Medical College and General Hospital, Nandyal from July 2014 to January 2015.60 patients belonging to physical status ASA - I and ASA - II of both sexes were selected (aged between 5 - 35 yrs.Pat ients in group - I (n=30 received Granisetron 40 mcg/kg and group – II (n=30 patients received Granisetron 40 mcg/kg and Dexamethasone 150 mcg/kg intravenously just before the start of operation. The whole postoperative period of 24 hrs was divided into 2 p hases ; early 0 - 6 hrs and late phase 6 - 24 hrs. RESULTS: Nausea and Vomiting score was significantly higher in group - I patients (P<0.05.The total incidence of nausea and vomiting was reduced from 43% in group - I to 6.6% in group - II which was statistically si gnificant (p<0.05 . CONCLUSION: Granisetron and Dexamethasone combination is more effective for the prevention of PONV in comparison to Granisetron alone in ENT surgeries

  1. Impacts of Combined Cooling, Heating and Power Systems, and Rainwater Harvesting on Water Demand, Carbon Dioxide, and NOx Emissions for Atlanta.

    Science.gov (United States)

    James, Jean-Ann; Sung, Sangwoo; Jeong, Hyunju; Broesicke, Osvaldo A; French, Steven P; Li, Duo; Crittenden, John C

    2018-01-02

    The purpose of this study is to explore the potential water, CO 2 and NO x emission, and cost savings that the deployment of decentralized water and energy technologies within two urban growth scenarios can achieve. We assess the effectiveness of urban growth, technological, and political strategies to reduce these burdens in the 13-county Atlanta metropolitan region. The urban growth between 2005 and 2030 was modeled for a business as usual (BAU) scenario and a more compact growth (MCG) scenario. We considered combined cooling, heating and power (CCHP) systems using microturbines for our decentralized energy technology and rooftop rainwater harvesting and low flow fixtures for the decentralized water technologies. Decentralized water and energy technologies had more of an impact in reducing the CO 2 and NO x emissions and water withdrawal and consumption than an MCG growth scenario (which does not consider energy for transit). Decentralized energy can reduce the CO 2 and NO x emissions by 8% and 63%, respectively. Decentralized energy and water technologies can reduce the water withdrawal and consumption in the MCG scenario by 49% and 50% respectively. Installing CCHP systems on both the existing and new building stocks with a net metering policy could reduce the CO 2 , NO x , and water consumption by 50%, 90%, and 75% respectively.

  2. Validation of functional fetal autonomic brain age score fABAS in 5 min short recordings

    International Nuclear Information System (INIS)

    Hoyer, Dirk; Kowalski, Eva-Maria; Schmidt, Alexander; Witte, Otto W; Schneider, Uwe; Schleußner, Ekkehard; Hatzmann, Wolfgang; Grönemeyer, Dietrich HW; Van Leeuwen, Peter

    2015-01-01

    With the objective of evaluating the functional maturation age and developmental disturbances we have previously introduced the fetal autonomic brain age score (fABAS) using 30 min fetal magnetocardiographic recordings (fMCG, Jena). The score is based on heart rate pattern indices that are related to universal principles of developmental biology. The present work aims at the validation of the fABAS methodology on 5 min recordings from an independent database (fMCG, Bochum).We found high agreement of fABAS obtained from Jena normal fetuses (5 min subsets, n  =  364) and Bochum recordings (n  =  322, normal fetuses). fABAS of 48 recordings from fetuses with intra-uterine growth restriction (IUGR, Bochum) was reduced in most of the cases, a result consistent with IUGR fetuses from Jena previously reported. fABAS calculated from 5 min snapshots only partly covers the accuracy when compared to fABAS from 30 min recordings. More precise diagnosis requires longer recordings.fABAS obtained from fMCG recordings is a strong candidate for standardized assessment of functional maturation age and developmental disturbances. Even 5 min recordings seem to be valuable for screening for maturation problems. (paper)

  3. The 27 Possible Intrinsic Symmetry Groups of Two-Component Links

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    Jason Parsley

    2012-02-01

    Full Text Available We consider the “intrinsic” symmetry group of a two-component link L, defined to be the image ∑(L of the natural homomorphism from the standard symmetry group MCG(S3, L to the product MCG(S3 × MCG(L. This group, first defined by Whitten in 1969, records directly whether L is isotopic to a link L′ obtained from L by permuting components or reversing orientations; it is a subgroup of Γ2, the group of all such operations. For two-component links, we catalog the 27 possible intrinsic symmetry groups, which represent the subgroups of Γ2 up to conjugacy. We are able to provide prime, nonsplit examples for 21 of these groups; some are classically known, some are new. We catalog the frequency at which each group appears among all 77,036 of the hyperbolic two-component links of 14 or fewer crossings in Thistlethwaite’s table. We also provide some new information about symmetry groups of the 293 non-hyperbolic two-component links of 14 or fewer crossings in the table.

  4. [Comparison of the Pressure on the Larynx and Tongue Using McGRATH® MAC Video Laryngoscope--Direct Vision versus Indirect Vision].

    Science.gov (United States)

    Tanaka, Yasutomo; Miyazaki, Yukiko; Kitakata, Hidenori; Shibuya, Hiromi; Okada, Toshiki

    2015-12-01

    Studies show that McGRATH® MAC (McG) is useful during direct laryngoscopy. However, no study has examined whether McG re- duces pressure on the upper airway tract We compared direct vision with indirect vision concerning pressure on the larynx and tongue. Twenty two anesthesiologists and 16 junior residents attempted direct laryngoscopy of airway management simulator using McG with direct vision and indirect vision. Pressure was measured using pressure measurement film. In anesthesiologists group, pressure on larynx was 14.8 ± 2.7 kgf · cm(-2) with direct vision and 12.7 ± 2.7 kgf · cm(-2) with indirect vision (P vision and 7.6 ± 2.8 kgf · cm(-2) with indirect vision (P = 0.18). In junior residents group, pressure on larynx was 19.0 ± 1.3 kgf · cm(-2) with direct vision and 14.1 ± 3.1 kgf · cm(-2) with indirect vision (P vision and 11.2 ± 4.7 kgf · cm(-2) with indirect vision (P vision can reduce pressure on the upper airway tract.

  5. Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.

    Science.gov (United States)

    Pacchiarotti, Alessandro; Carlomagno, Gianfranco; Antonini, Gabriele; Pacchiarotti, Arianna

    2016-01-01

    Polycystic ovarian syndrome (PCOS) induces anovulation in women of reproductive age, and is one of the pathological factors involved in the failure of in vitro fertilization (IVF). Indeed, PCOS women are characterized by poor quality oocytes. Therefore, a treatment for enhancing oocyte quality becomes crucial for these patients. Myo-Inositol and melatonin proved to be efficient predictors for positive IVF outcomes, correlating with high oocyte quality. We tested the synergistic effect of myo-inositol and melatonin in IVF protocols with PCOS patients in a randomized, controlled, double-blind trial. Five-hundred twenty-six PCOS women were divided into three groups: Controls (only folic acid: 400 mcg), Group A (Inofolic® plus, a daily dose of myo-inositol: 4000 mg, folic acid: 400 mcg, and melatonin: 3 mg), and Group B (Inofolic®, a daily dose of myo-inositol: 4000 mg, and folic acid: 400 mcg). The main outcome measures were oocyte and embryo quality, clinical pregnancy and implantation rates. The treatment lasted from the first day of the cycle until 14 days after embryo transfer. Myo-inositol and melatonin have shown to enhance, synergistically, oocyte and embryo quality. In consideration of the beneficial effect observed in our trial and on the bases of previous studies, we decided to integrate routinely MI and M supplementation in the IVF protocols. The same treatment should be taken carefully in consideration in all procedures of this kind.

  6. Blood Lead Level in Children with Neurological Disorders.

    Science.gov (United States)

    Parhoudeh, Marzieh; Inaloo, Soroor; Zahmatkeshan, Mozhgan; Seratishirazi, Zahra; Haghbin, Saeedeh

    2018-01-01

    We aimed to investigate the blood lead level (BLL) in children with neurologic disorders of unknown causes and compare with normal children. In this prospective case-control study, 68 patients aged 1 to 18 yr with neurologic disorders of unknown causes, were referred to pediatric neurology clinics and wards, Shiraz, Iran selected during a 12 months period from Sep 2013. They were compared with 1:1 ratio, age, and sex-matched healthy children. BLL was checked from all participants using 3 cc heparinized venous blood sample. Level of ≥5 mcg/dl was considered toxic dose. Totally, 136 children (68 cases and 68 controls) with mean ages of 5.20±4.12 and 4.18±3.86 yr, respectively, were enrolled. Mean BLL was higher in case group than in controls but the difference was not significant ( P =0.84), though they were less than toxic levels in both. In addition, the difference in mean BLLs was not significant in terms of living place, sex, and age. Totally, 17.7% of the study sample had BLL ≥5 mcg/dl. The frequency of BLL ≥5 mcg/dl was significantly higher in case group ( P =0.024) with an odds ratio 2.9 times higher (95% CI: 1.066-7.60). Strategies in public health must focus on practicing primary and secondary preventions of lead exposure in children.

  7. Influence of excessive iodine intake on the thyroid function and spectrum of thyroid abnormalities in population of Turinsk, Sverdlovsk Region, of Russia

    Directory of Open Access Journals (Sweden)

    Aleksey V. Kiyaev

    2015-05-01

    Full Text Available Background. Previous surveys showed chronic iodine excess - median urinary iodine concentration (UIC over 500 mcg/l — supposedly due to water contamination in population of Turinsk, a town in Sverdlovsk Region of Russia. Aim. Conduct an assessment of the effects of chronic iodine excess on thyroid function and spectrum of thyroid abnormalities in schoolchildren and adults. Materials and methods. Assessment was conducted in 100 schoolchildren and 100 adults residing in Turinsk and 97 schoolchildren and 100 adults in the control site (city of Pervouralsk with optimal UIC. Assessment included thyroid ultrasonogrpahy, urinary iodine and dry spot TSH in schoolchildren and TSH and TPO-ab in adults. Iodine was also measured in random water samples from 10 households in Turinsk. Results. Median UIC in schoolchildren in Turinsk (719 mcg/l was significantly higher (129 mcg/l than in Pervouralsk resulting in higher prevalence of thyroid enlargement and TSH level. In adults TSH level as well as prevalence of sub-clinical hypothyroidism and autoimmune thyroiditis were higher in residents of Turinsk compared to control group from Pervouralsk. Conclusions. Iodine excess alters thyroid function in schoolchildren and adults increasing prevalence of thyroid enlargement in children and autoimmune thyroidis in adults.

  8. Optimal filter design for shielded and unshielded ambient noise reduction in fetal magnetocardiography

    International Nuclear Information System (INIS)

    Comani, S; Mantini, D; Alleva, G; Luzio, S Di; Romani, G L

    2005-01-01

    The greatest impediment to extracting high-quality fetal signals from fetal magnetocardiography (fMCG) is environmental magnetic noise, which may have peak-to-peak intensity comparable to fetal QRS amplitude. Being an unstructured Gaussian signal with large disturbances at specific frequencies, ambient field noise can be reduced with hardware-based approaches and/or with software algorithms that digitally filter magnetocardiographic recordings. At present, no systematic evaluation of filters' performances on shielded and unshielded fMCG is available. We designed high-pass and low-pass Chebychev II-type filters with zero-phase and stable impulse response; the most commonly used band-pass filters were implemented combining high-pass and low-pass filters. The achieved ambient noise reduction in shielded and unshielded recordings was quantified, and the corresponding signal-to-noise ratio (SNR) and signal-to-distortion ratio (SDR) of the retrieved fetal signals was evaluated. The study regarded 66 fMCG datasets at different gestational ages (22-37 weeks). Since the spectral structures of shielded and unshielded magnetic noise were very similar, we concluded that the same filter setting might be applied to both conditions. Band-pass filters (1.0-100 Hz) and (2.0-100 Hz) provided the best combinations of fetal signal detection rates, SNR and SDR; however, the former should be preferred in the case of arrhythmic fetuses, which might present spectral components below 2 Hz

  9. THE IMPACT OF GLOSS TYPES ON IRANIAN EFL STUDENTS’ READING COMPREHENSION AND LEXICAL RETENTION

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    Mohammad Taghi Farvardin

    2012-01-01

    Full Text Available Research has shown that the effect of marginal glosses on reading comprehension and vocabulary retention is a controversial issue. The purpose of this study was to investigate this issue among Iranian university EFL students. Three types of glosses were applied in this study: single gloss in participants’ first language (SL1G, single gloss in participants’ second language (SL2G, and multiple-choice gloss (MCG in participants’ second language. One hundred and twenty undergraduate students majoring in English Teaching at Azad University of Najafabad, Iran, read the texts under three conditions: SL1G, SL2G, and MCG. Afterwards, participants answered two vocabulary tests, one administered immediately after the reading test and another three weeks later. One-way repeated measures ANOVA and follow-up post hoc tests (p<.05 showed that MCG facilitated participants’ vocabulary learning while reading the text more than SLGs. The results of One-way ANOVA also revealed that SL2G was the most facilitative gloss type for the participants’ reading comprehension. The study illustrates how different types of textual glosses can affect both reading comprehension and vocabulary retention. Limitations and suggestions for future research are discussed.

  10. Design and Characterization of Low-noise Dewar for High-sensitivity SQUID Operation

    International Nuclear Information System (INIS)

    Yu, K. K.; Lee, Y. H.; Kim, K.; Kwon, H.; Kim, J. M.

    2010-01-01

    We have fabricated the low noise liquid helium(LHe) dewar with a different shape of thermal shield to apply the 64-channel SQUID(Superconducting Quantum Interference Device) gradiometer. The first shape of thermal shield was made of an aluminum plate with a wide width of 100 mm slit and the other shape was modified with a narrow width of 20 mm slit. The two types of dewars were estimated by comparing the thermal noise and the signal-to-noise ratio(SNR) of magnetocardiography(MCG) using the 1st order SQUID gradiometer system cooled each dewar. The white noise was different as a point of the dewar. The noise was increased as close as the edge of dewar, and also increased at the thermal shield with the more wide width slit. The white noise of the dewar with thermal shield of 100 mm slit was 6.5 fT/Hz 1/2 at the center of dewar and 25 fT/Hz 1/2 at the edge, and the white noise of the other one was 3.5 - 7 fT/Hz 1/2 . We measured the MCG using 64-channel SQUID gradiometer cooled at each LHe dewar and compared the SNR of MCG signal. The SNR was improved of 10 times at the LHe dewar with a modified thermal shield.

  11. Reconstruction of action potential of repolarization in patients with congenital long-QT syndrome

    International Nuclear Information System (INIS)

    Kandori, Akihiko; Shimizu, Wataru; Yokokawa, Miki; Kamakura, Shiro; Miyatake, Kunio; Murakami, Masahiro; Miyashita, Tsuyoshi; Ogata, Kuniomi; Tsukada, Keiji

    2004-01-01

    A method for reconstructing an action potential during the repolarization period was developed. This method uses a current distribution-plotted as a current-arrow map (CAM)-calculated using magnetocardiogram (MCG) signals. The current arrows are summarized during the QRS complex period and subtracted during the ST-T wave period in order to reconstruct the action-potential waveform. To ensure the similarity between a real action potential and the reconstructed action potential using CAM, a monophasic action potential (MAP) and an MCG of the same patient with type-I long-QT syndrome were measured. Although the MAP had one notch that was associated with early afterdepolarization (EAD), the reconstructed action potential had two large and small notches. The small notch timing agreed with the occurrence of the EAD in the MAP. On the other hand, the initiation time of an abnormal current distribution coincides with the appearance timing of the first large notch, and its end time coincides with that of the second small notch. These results suggest that a simple reconstruction method using a CAM based on MCG data can provide a similar action-potential waveform to a MAP waveform without having to introduce a catheter

  12. Investigation of seed damaging pathogens associated with wheat crop in bhimber azad kashmir, pakistan and their managements

    International Nuclear Information System (INIS)

    Hussain, T.; Ishtiaq, M.; Azam, S.; Maqbool, M.; Mushtaq, W.

    2017-01-01

    Mycopathogens were explored from wheat germplasm cultivars from District Bhimber of Azad Kashmir. In this study, 10 different seed-borne pathogens were isolated from District of Bhimber, Azad Jammu and Kashmir, Pakistan. The Agar Plate Method (APM) and Towel Paper Method (TPM) were used for detection of seed borne pathogens. The disease incidence (percentage) and disease severity of fungi varied with respect to type of pathogen and seed sampling sites. Kernel bunt caused by Tilletia indica showed highest incidence (67.25%) and severity (7.0) on 0-9 rating scale. Fusarium graminearum showed the highest infection rate in three sub-divisions of district Bhimber as compared to others. The fungal attacking pathogens on wheat crop were control through fungicides treatment and treatments with plant extracts. Maximum germination rates were calculated in three sub-divisions of Bhimber after treatment of Tilt fungicide. As 86% germination rate in Samahni, 87.5% in Bhimber and 84.5% in Bernala was calculated. Antifungal activity of five plant extracts (Acacia nilotica L., Azadirachta indica L. Juss., Eucalyptus citriodora Hook, Ficus bengalensis L. and Allium sativum L.) were evaluated in four different solvents. Highest minimum inhibitory concentration (MIC) was calculated of all plants in methanolic extracts. Maximum MIC (57.38 mcg/ml) exhibited by extracts of Acacia nilotica leaves against ten fungi. Azadirachta indica extracts in different solvents against wheat-seed fungal pathogens was shown more antimicrobial activity as compared to other four plants. Azadirachta indica extract in methanol showed the highest mean of antifungal activity (62.20 mcg/ml) against ten different fungal pathogens. Antimicrobial activity (MIC) of Ficus bengalensis in different solvents against nine wheat-seed fungal pathogens was also investigated. Highest MIC was measured against B. graminis (57.50 mcg/ml) and S. macrospora (57.00 mcg/ml) by using methanolic extract of Ficus bengalensis

  13. SILVER NANOPARTICLES IN THE SOLUTION OF THE PROBLEM OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS

    Directory of Open Access Journals (Sweden)

    A. V. Zaharov

    2017-01-01

    Full Text Available The goal — a scientific evaluation of the effectiveness and safety of NHS in the treatment of experimental drug-resistant tuberculosis. Materials and methods. Used silver nanoparticles obtained by an electrochemical method. With a size of 5-60 nm, 120-270 kontsentratsiey- 1 mcm² and the size of the stabilizer shell — 2-5 nm. 750 crops studied Inhibitory activity of the silver nanoparticles in an isolated form and as part of a nanocomposite with chemotherapy in concentrations of 5; 25 and 50 mcg/ml. Defines the minimum inhibitory concentration of bactericidal nanoparticles composed of a nanocomposite with isoniazid. To evaluate the morphometry M.tuberculosis used atomic force microscopy. Toxicology nanopreparations studied 83 non-linear white mice and 146 white rats. Chemotherapeutic Activity nanopreparations determined on an experimental model of tuberculosis in 65 white male mice imbrednoy line BALB/c. Infectivity dose amount 5х106 colony forming units injected into the sinus venosus animal eyes. Isoniazid, nanoparticles and nanocomposite began administered 14 days after infection by intramuscular injection daily. Treatment efficacy was determined by comparing the evaluation criteria in the experimental and control groups of animals. Evaluated the following indicators: survival index, body mass index and weight of target organ, lesions index, index smear and inoculation of affected organs. Conducted pathological examination. Results. When using isoniazid, which had resistant pathogens, with silver nanoparticles full and significant inhibition of the growth of the M.tuberculosis observed in 49,2% of cases. When the concentration of the nanoparticles 5 mcg/ml in the composite bactericidal activity reached 91,3%. The minimum inhibitory concentration of silver nanoperticles in combination with isoniazid was 2,5 mcg/ml, the minimum bactericidal — 5 mcg /ml. There have been changes in the M.tuberculosis morphometry under the influence of the

  14. Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience.

    Science.gov (United States)

    Shingina, Alexandra; Ou, George; Takach, Oliver; Svarta, Sigrid; Kwok, Ricky; Tong, Jessica; Donaldson, Kieran; Lam, Eric; Enns, Robert

    2016-12-16

    To develop a prediction model aimed at identifying patients that may require higher than usual sedation doses during colonoscopy. A retrospective chart review on 5000 patients who underwent an outpatient colonoscopy at St. Paul's Hospital from 2009 to 2010 was conducted in order to develop a model for identifying patients who will require increased doses of sedatives. Potential predictor variables including age, gender, endoscopy indication, high sedation requirements during previous endoscopies, difficulty of the procedure, bowel preparation quality, interventions, findings as well as current use of benzodiazepines, opioids and alcohol were analyzed. The outcome of study was the use of high dose of sedation agents for the procedure. In particular, the high dose of sedation was defined as fentanyl greater than 50 mcg and midazolam greater than 3 mg. Analysis of 5282 patients (mean age 57 ± 12, 49% female) was performed. Most common indication for the procedure was screening colonoscopy (57%). Almost half of our patients received doses exceeding Fentanyl 50 mcg and Midazolam 3 mg. Logistic regression models identified the following variables associated with high sedation: Younger age (OR = 0.95 95%CI: 0.94-0.95; P value of high sedation requirements. Our prediction model using the following pre-procedural variables including age, gender, indication for the procedure, medication/substance use, previous surgeries, previous high sedation requirements for colonoscopy yielded an area under the curve of 0.76 for Fentanyl ≥ 100 mcg and Midazolam ≥ 3 mg. Pre-procedural planning is the key in conducting successful, efficient colonoscopy. Logistic regression analysis of 5000 patients who underwent out-patient colonoscopy revealed the following factors associated with increased sedation requirement: Younger age, female gender, difficult endoscopy, specific indications as well as cardiopulmonary complications and current use of opioids/benzodiazepines. Age and gender

  15. A persisting secondhand smoke hazard in urban public places: results from fine particulate (PM2.5) air sampling.

    Science.gov (United States)

    Wilson, Nick; Edwards, Richard; Parry, Rhys

    2011-03-04

    To assess the need for additional smokefree settings, by measuring secondhand smoke (SHS) in a range of public places in an urban setting. Measurements were made in Wellington City during the 6-year period after the implementation of legislation that made indoor areas of restaurants and bars/pubs smokefree in December 2004, and up to 20 years after the 1990 legislation making most indoor workplaces smokefree. Fine particulate levels (PM2.5) were measured with a portable real-time airborne particle monitor. We collated data from our previously published work involving random sampling, purposeful sampling and convenience sampling of a wide range of settings (in 2006) and from additional sampling of selected indoor and outdoor areas (in 2007-2008 and 2010). The "outdoor" smoking areas of hospitality venues had the highest particulate levels, with a mean value of 72 mcg/m3 (range of maximum values 51-284 mcg/m3) (n=20 sampling periods). These levels are likely to create health hazards for some workers and patrons (i.e., when considered in relation to the WHO air quality guidelines). National survey data also indicate that these venues are the ones where SHS exposure is most frequently reported by non-smokers. Areas inside bars that were adjacent to "outdoor" smoking areas also had high levels, with a mean of 54 mcg/m3 (range of maximum values: 18-239 mcg/m3, for n=13 measurements). In all other settings mean levels were lower (means: 2-22 mcg/m3). These other settings included inside traditional style pubs/sports bars (n=10), bars (n=18), restaurants (n=9), cafes (n=5), inside public buildings (n=15), inside transportation settings (n=15), and various outdoor street/park settings (n=22). During the data collection in all settings made smokefree by law, there was only one occasion of a person observed smoking. The results suggest that compliance in pubs/bars and restaurants has remained extremely high in this city in the nearly six years since implementation of the

  16. Diffuse Non-toxic Goitre Therapy with Iodine Alone or with Combination of Iodine and Levothyroxine

    Directory of Open Access Journals (Sweden)

    N Galkina

    2008-12-01

    Full Text Available Aim: to assess the efficacy and tolerability of low-dose iodine therapy compared with the combination of iodine and levothyroxine in endemic goitre patients. Methods: 12-month prospective study was performed, in which 81 patients were randomized on two groups: Group 1 (n = 40 - KI (200 micrograms/day and Group 2 (n = 41 - KI (100 mcg/day + L-T4 (1.0 mcg/kg. Thyroid volume, TSH and Anti-TPO-Ab levels were evaluated at baseline, at 8 month of the treatment and at 12 month (4 month after the cessation of the therapy. Results: the significant decreasing of thyroid volumes was found in group 1 at 8 month compared with baseline (20.5 ml at baseline and 16,4 ml at 8 month р < 0.001. After the therapy cessation the further benefit of a sustained effect was demonstrated (16.4 ml at 8 month and 16.1 ml at 12 month, р = 0.31. Iodine-induced hypo- and hyperthyroidism were not observed. High Anti-TPO-Ab level was found in one of 31 patients (3%. In group 2 significant difference between thyroid volumes was found at 8 month compared with baseline (20,5 ml at baseline and 16.2 ml at 8 month р < 0.001. The sustained effect was revealed at least 4 month after the therapy cessation (16.2 ml at 8 month and 16.1 ml at 12 month, р = 0.77. One man had iodine-induced subclinical hyperthyroidism. Anti-TPO-Ab was not detected in this group. No significant difference between thyroid volume decreasing, TSH and Anti-TPO-Ab levels in two comparable groups was observed. Conclusion: KI alone (200 mcg/day or the combination of L-T4 (1.0 mcg/kg and KI (100 mcg/day are equally effective and tolerable for endemic goitre therapy.

  17. Study on the thyroid function of thoroughbred horses by means of 'in vitro' /sup 125/I-T/sub 3/ modified and /sup 125/I-T/sub 4/ tests

    Energy Technology Data Exchange (ETDEWEB)

    de Martin, B W [Sao Paulo Univ. (Brazil). Faculdade de Medicina Veterinaria e Zootecnia

    1975-01-01

    Sera of 71 animals, divided in groups of males and females, in repose and after activity were studied. The method to establish the percentage of the /sup 125/I-lyothyronine retention in resin (Test /sup 125/I-T/sub 3/ or T/sub 3/) was modified by the use of 0.2 ml of serum on the resin column, after addition of the marked hormone. This modification served to prove that thoroughbred equines show binding of the I-lyothyronine to the serum four times reduced, indicating, therefore, that these animals have four times more ligation sites of triidothyronin saturation in the serum, when compared with the results obtained from human beings. The variance analysis applied to the T/sub 3/ Test showed no significant results at the 95% level as regards to activity. For the 71 animals, the author has found an average of 50.30% of the /sup 125/I-Lyothyronine in resin retention, being the confidence interval for this group between 48.75% and 51.85% to a 95% confidence coefficient. Evaluating the results of the T/sub 4/ Test by means of the variance analysis, we noticed that the male and female groups in repose differed statistically from the groups after activity to a 95% confidence coefficient. The author has grouped the results of the T/sub 4/ Test of 32 equines, 18 males and 14 females, in repose, obtaining an average of 0.61 mcg and 0.51 mcg and 0.71 mcg T/sub 4//100 ml as confidence interval to a 95% confidence coefficient. We have listed 39 results of T/sub 4/ Test, being 23 males and 61 Females, after activity, obtaining an average of 2.01 mcg of thyroxin by 100 ml of serum and 1.72 mcg and 2.30 T/sub 4//100 ml as confidence interval to a 95% confidence coefficient.

  18. A tetrameric peptide derived from bovine lactoferricin as a potential therapeutic tool for oral squamous cell carcinoma: A preclinical model.

    Science.gov (United States)

    Solarte, Víctor Alfonso; Conget, Paulette; Vernot, Jean-Paul; Rosas, Jaiver Eduardo; Rivera, Zuly Jenny; García, Javier Eduardo; Arango-Rodríguez, Martha Ligia

    2017-01-01

    Oral squamous cell carcinoma is the fifth most common epithelial cancer in the world, and its current clinical treatment has both low efficiency and poor selectivity. Cationic amphipathic peptides have been proposed as new drugs for the treatment of different types of cancer. The main goal of the present work was to determine the potential of LfcinB(20-25)4, a tetrameric peptide based on the core sequence RRWQWR of bovine lactoferricin LfcinB(20-25), for the treatment of OSCC. In brief, OSCC was induced in the buccal pouch of hamsters by applying 7,12-Dimethylbenz(a)anthracene, and tumors were treated with one of the following peptides: LfcinB(20-25)4, LfcinB(20-25), or vehicle (control). Lesions were macroscopically evaluated every two days and both histological and serum IgG assessments were conducted after 5 weeks. The size of the tumors treated with LfcinB(20-25)4 and LfcinB(20-25) was smaller than that of the control group (46.16±4.41 and 33.92±2.74 mm3 versus 88.77±10.61 mm3, respectively). Also, LfcinB(20-25)4 caused acellularity in the parenchymal tumor compared with LfcinB(20-25) and vehicle treatments. Furthermore, our results demonstrated that both LfcinB(20-25)4 and LfcinB(20-25) induced higher degree of apoptosis relative to the untreated tumors (75-86% vs 8%, respectively). Moreover, although the lowest inflammatory response was achieved when LfcinB(20-25)4 was used, this peptide appeared to induce higher levels of IgG antibodies relative to the vehicle and LfcinB(20-25). In addition the cellular damage and selectivity of the LfcinB(20-25)4 peptide was evaluated in vitro. These assays showed that LfcinB(20-25)4 triggers a selective necrotic effect in the carcinoma cell line. Cumulatively, these data indicate that LfcinB(20-25)4 could be considered as a new therapeutic agent for the treatment of OSCC.

  19. A tetrameric peptide derived from bovine lactoferricin as a potential therapeutic tool for oral squamous cell carcinoma: A preclinical model.

    Directory of Open Access Journals (Sweden)

    Víctor Alfonso Solarte

    Full Text Available Oral squamous cell carcinoma is the fifth most common epithelial cancer in the world, and its current clinical treatment has both low efficiency and poor selectivity. Cationic amphipathic peptides have been proposed as new drugs for the treatment of different types of cancer. The main goal of the present work was to determine the potential of LfcinB(20-254, a tetrameric peptide based on the core sequence RRWQWR of bovine lactoferricin LfcinB(20-25, for the treatment of OSCC. In brief, OSCC was induced in the buccal pouch of hamsters by applying 7,12-Dimethylbenz(aanthracene, and tumors were treated with one of the following peptides: LfcinB(20-254, LfcinB(20-25, or vehicle (control. Lesions were macroscopically evaluated every two days and both histological and serum IgG assessments were conducted after 5 weeks. The size of the tumors treated with LfcinB(20-254 and LfcinB(20-25 was smaller than that of the control group (46.16±4.41 and 33.92±2.74 mm3 versus 88.77±10.61 mm3, respectively. Also, LfcinB(20-254 caused acellularity in the parenchymal tumor compared with LfcinB(20-25 and vehicle treatments. Furthermore, our results demonstrated that both LfcinB(20-254 and LfcinB(20-25 induced higher degree of apoptosis relative to the untreated tumors (75-86% vs 8%, respectively. Moreover, although the lowest inflammatory response was achieved when LfcinB(20-254 was used, this peptide appeared to induce higher levels of IgG antibodies relative to the vehicle and LfcinB(20-25. In addition the cellular damage and selectivity of the LfcinB(20-254 peptide was evaluated in vitro. These assays showed that LfcinB(20-254 triggers a selective necrotic effect in the carcinoma cell line. Cumulatively, these data indicate that LfcinB(20-254 could be considered as a new therapeutic agent for the treatment of OSCC.

  20. Effect of antioxidants on the performance and emission characteristics of a diesel engine fuelled by waste cooking sunflower methyl ester

    Science.gov (United States)

    Reddy, V. Puneeth Kumar; Senthil Kumar, D.; Thirumalini, S.

    2018-02-01

    Biodiesel is a renewable, biodegradable fuel produced from vegetable oils and animal fats. Nonetheless, its extensive utilization is impeded by the auto-oxidation resulting in degradation of the fuel. Adding antioxidants to the biodiesel is a potential solution, but it might have an effect on the clean-burning characteristics of the fuel. This paper investigates the effect of antioxidants on the performance and emission characteristics of a diesel engine fuelled by the waste cooking sunflower methyl ester. The fuel samples tested include B10, B20, B30 and B40, among which B20 produced the best possible results. Antioxidants 2, 6-ditert-butyl-4-methylphenol (BHA) and 2(3)-tert-butyl-4-methoxy phenol (BHT) of two concentrations 1000 ppm, 2000 ppm were added to B20 to evaluate the effectiveness. B20BHA1000 had the best effect with an average decrease of 5.035%, 2.02% in brake specific fuel consumption (BSFC) and exhaust gas temperature (EGT) compared to B20. Regarding the emission characteristics it was observed that B20BHA1000 had produced an increase of 7.21%, 27.79% in NOx and smoke emissions and a decrease of 33.33% in HC emissions when compared to B20. On the whole, without any requirement of alteration in the diesel engines, B20 blends with antioxidant can be utilized as fuel.

  1. Performance, Emission, Energy, and Exergy Analysis of a C.I. Engine Using Mahua Biodiesel Blends with Diesel.

    Science.gov (United States)

    Panigrahi, Nabnit; Mohanty, Mahendra Kumar; Mishra, Sruti Ranjan; Mohanty, Ramesh Chandra

    2014-01-01

    This paper presents an experimental investigation on a four-stroke single cylinder diesel engine fuelled with the blends of Mahua oil methyl ester (MOME) and diesel. The performance emission, energy, and exergy analysis has been carried out in B20 (mixture of 80% diesel by volume with 20% MOME). From energy analysis, it was observed that the fuel energy input as well as energy carried away by exhaust gases was 6.25% and 11.86% more in case of diesel than that of B20. The unaccounted losses were 10.21% more in case of diesel than B20. The energy efficiency was 28%, while the total losses were 72% for diesel. In case of B20, the efficiency was 65.74 % higher than that of diesel. The exergy analysis shows that the input availability of diesel fuel is 1.46% more than that of B20. For availability in brake power as well as exhaust gases of diesel were 5.66 and 32% more than that of B20. Destructed availability of B20 was 0.97% more than diesel. Thus, as per as performance, emission, energy, and exergy part were concerned; B20 is found to be very close with that of diesel.

  2. Alternative Fuels Data Center: Vermont Transportation Data for Alternative

    Science.gov (United States)

    alternative fuels Fuel Public Private Biodiesel (B20 and above) 3 0 Compressed Natural Gas (CNG) 1 2 Electric Recycled Cooking Oil Powers Biodiesel Vehicles in Vermont Recycled Cooking Oil Powers Biodiesel Vehicles in sold per GGE Biodiesel (B20) $2.79/gallon $2.54/GGE $2.84/gallon $2.58/GGE Biodiesel (B99-B100) $2.47

  3. Alternative Fuels Data Center: New Mexico Transportation Data for

    Science.gov (United States)

    to alternative fuels and advanced vehicles Recent Additions and Updates Biodiesel Blend Mandate Public Private Biodiesel (B20 and above) 1 4 Compressed Natural Gas (CNG) 8 3 Electric 59 4 Ethanol (E85 GGE Biodiesel (B20) $2.60/gallon $2.37/GGE $2.84/gallon $2.58/GGE Biodiesel (B99-B100) $2.49/gallon

  4. Alternative Fuels Data Center: Virginia Transportation Data for Alternative

    Science.gov (United States)

    /2018 Biodiesel and Green Diesel Definitions updated 4/9/2018 Data Download Fueling Stations 706 stations in Virginia with alternative fuels Fuel Public Private Biodiesel (B20 and above) 1 9 Compressed unit sold per GGE per unit sold per GGE Biodiesel (B20) $2.47/gallon $2.25/GGE $2.84/gallon $2.58/GGE

  5. Influence of polymethyl acrylate additive on the formation of particulate matter and NOX emission of a biodiesel-diesel-fueled engine.

    Science.gov (United States)

    Monirul, Islam Mohammad; Masjuki, Haji Hassan; Kalam, Mohammad Abdul; Zulkifli, Nurin Wahidah Mohd; Shancita, Islam

    2017-08-01

    The aim of this study is to investigate the effect of the polymethyl acrylate (PMA) additive on the formation of particulate matter (PM) and nitrogen oxide (NO X ) emission from a diesel coconut and/or Calophyllum inophyllum biodiesel-fueled engine. The physicochemical properties of 20% of coconut and/or C. inophyllum biodiesel-diesel blend (B20), 0.03 wt% of PMA with B20 (B20P), and diesel fuel were measured and compared to ASTM D6751, D7467, and EN 14214 standard. The test results showed that the addition of PMA additive with B20 significantly improves the cold-flow properties such as pour point (PP), cloud point (CP), and cold filter plugging point (CFPP). The addition of PMA additives reduced the engine's brake-specific energy consumption of all tested fuels. Engine emission results showed that the additive-added fuel reduce PM concentration than B20 and diesel, whereas the PM size and NO X emission both increased than B20 fuel and baseline diesel fuel. Also, the effect of adding PMA into B20 reduced Carbon (C), Aluminum (Al), Potassium (K), and volatile materials in the soot, whereas it increased Oxygen (O), Fluorine (F), Zinc (Zn), Barium (Ba), Chlorine (Cl), Sodium (Na), and fixed carbon. The scanning electron microscope (SEM) results for B20P showed the lower agglomeration than B20 and diesel fuel. Therefore, B20P fuel can be used as an alternative to diesel fuel in diesel engines to lower the harmful emissions without compromising the fuel quality.

  6. Adecuación de la dieta servida a escolares en albergues indigenistas de la Sierra Tarahumara, México Adequacy of the diet served to Tarahumara children in indigenous boarding schools of northern Mexico

    Directory of Open Access Journals (Sweden)

    Joel Monárrez-Espino

    2010-02-01

    Full Text Available OBJETIVO: Evaluar la adecuación y variación de la dieta servida a escolares de albergues indigenistas. MATERIAL Y MÉTODOS: Durante diez semanas se evaluó la dieta servida en dos albergues documentando el tipo/cantidad de ingredientes empleados para preparar alimentos/bebidas y registrando la ración ofrecida mediante la técnica de pesos y medidas; se analizó la dieta servida los martes-miércoles-jueves de las semanas 3-5-7. RESULTADOS: Se utilizaron 33-46 ingredientes/semana; los más frecuentes fueron aceite, tortillas de harina de maíz fortificada, leche, cebolla, azúcar y frijol. La energía total en la ración diaria fluctuó entre 1309 y 2919 kcal; las proteínas constituyeron 10.5-21.2% (45-127 g/día, los hidratos de carbono 40.7-61.9% (145-433 g/día, y los lípidos 22.5-48.1% (45-125 g/día. El contenido diario de micronutrimentos fue el siguiente: hierro, 15-33 mg; calcio, 686-1795 mg; zinc, 8-19 mg; vitamina A, 118-756 mcg; vitamina B9, 42-212 mcg y vitamina B12, 0.8-5 mcg. CONCLUSIÓN: Existe una variación importante en la dieta servida que resulta relativamente hipercalórica por exceso de lípidos, pero con un contenido insuficiente de vitaminas B9, B12 y A.OBJECTIVE: To assess the adequacy and variability of the diet served to Tarahumara children in indigenous boarding schools. MATERIAL AND METHODS: Records of food and drinks served for meals, weighed daily, were obtained from Monday through Friday for 10 consecutive weeks in two selected boarding schools. Nutrient intake for Tuesdays, Wednesdays and Thursdays was calculated and analyzed for weeks 3, 5 and 7. RESULTS: The number of food items used per week ranged from 33 to 46. The most frequently utilized items were cooking oil, fortified corn tortilla, milk, onion, sugar and beans. Total energy served per day fluctuated between 1309 and 2919 Kcal; proteins comprised 10.5 to 21.2% (45 to 127 g/day, carbohydrates 40.7 to 61.9% (145 to 433 g/day, and lipids 22.5 to 48

  7. Indoor particulate matter measurement as a tool in the process of the implementation of smoke-free hospitals.

    Science.gov (United States)

    Nardini, S; Cagnin, R; Invernizzi, G; Ruprecht, A; Boffi, R; Formentini, S

    2004-01-01

    There are International and National standards that requires hospitals and health premises to be smoke-free. According to recent data from Italy and other European Countries, smoking is a widespread habit in hospitals. To get smoke-free hospitals in an Italian region, we have adopted the European Code for smoke-free hospitals, which sets standards and provides instruments for its implementation. According to the Code, whenever possible, each step towards a smoke-free hospital, should be shared by all staff. As a mean for achieving this goal, in our region the certification of single units as smoke-free units has been chosen. For getting the certification, besides implementing the Code, we planned to use ETS (Environmental Tobacco Smoke) monitoring, as ETS should not be present in hospitals. As a marker of ETS we have chosen Particulate Matter (PM), as it can easily be measured in real-time with a portable instrument and, when other even outdoor--sources of combustion can be ruled out, it is an accurate detector of cigarette smoke. Here the first experience of measuring PM in hospitals for monitoring ETS and certificating smoke-free health premises, is described. PM measurements were carried out without any previous notification in different areas of two Network hospitals of the Veneto Region, during a single working day. A real time laser-operated aerosol mass analyser was used. Several classes of PM (PM1, PM2.5, PM7, PM10, TSP Total Suspended Particles) were measured. Outdoor PM levels were found to be repeatedly lower than the annual official limits of 65 mcg/m3 and around the 24 hour official limits of 15 mcg/m3 [15 to 20 mcg/m3, with an overall mean (+/-SD) of 17.8 (1.9)] throughout the whole day. Very good indoor air quality was found in the operating theaters and isolation department, where PM2.5 concentrations were much lower than outdoor levels [1.6 (0.9) and 5.9 (0.6) mcg/m3, respectively]. No increase in PM pollution was found in the surveyed medical

  8. Comparação entre três métodos de coloração a frio no diagnóstico primário de tuberculose: um estudo piloto Comparison among three cold staining methods in the primary diagnosis of tuberculosis: a pilot study

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    Soham Gupta

    2010-10-01

    Full Text Available OBJETIVO: Em países em desenvolvimento, a baciloscopia é a principal ferramenta para a identificação de casos de tuberculose pulmonar. O objetivo do presente estudo foi avaliar a eficácia diagnóstica do método de coloração de Gabbett (MCG e de um método modificado de coloração a frio (MMC, ambos em duas etapas, em comparação com a do método de coloração fluorescente (MCF, em três etapas, para a detecção de BAAR em esfregaços de escarro. MÉTODOS: Nossa amostra consistiu de 260 amostras de escarro coletadas de casos suspeitos de tuberculose pulmonar no Kasturba Hospital, em Manipal, Índia. Os esfregaços foram preparados em triplicata, para cada um dos métodos: MCF, MMC e MCG. As lâminas foram numeradas aleatoriamente a fim de que o examinador fosse cegado quanto à identidade das amostras. RESULTADOS: Das 260 amostras, 16 (6,15%, 15 (5,77% e 13 (5,00% foram positivas para BAAR com MCF, MMC e MCG, respectivamente. A sensibilidade de MCG e MMC em relação à de MCF foi de 81,25% e 93,75%, respectivamente. Houve boa concordância de MCG e MMC com MCF (0,988 e 0,996, respectivamente, e não houve diferenças estatísticas significativas. CONCLUSÕES: Embora MCG e MMC apresentaram menor sensibilidade que MCF, que é avaliado por microscopia de fluorescência, consideramos que os dois primeiros métodos sejam promissores no diagnóstico de tuberculose.OBJECTIVE: In developing countries, sputum smear microscopy is the main tool for pulmonary tuberculosis case finding. The objective of the present study was to evaluate the diagnostic efficacy of Gabbett's staining (GS and modified cold staining (MCS, both of which are two-step methods, in comparison with that of fluorescent staining (FS, which is a three-step method, for the detection of AFB in sputum smears. METHODS: Our sample comprised 260 sputum samples collected from individuals suspected of having pulmonary tuberculosis at Kasturba Hospital, in Manipal, India. Smears were

  9. Effect of nature based antioxidant from Zingiber officinale Rosc. on the oxidation stability, engine performance and emission characteristics with neem oil methyl ester

    Science.gov (United States)

    Karthickeyan, V.

    2018-05-01

    In past few years, the demand for energy increased drastically due to excess utilization of the natural reserves. Thus, it leads to extinction of non-renewable energy resources. Today, the world turning over renewable source of energy for power production (like wind energy, tidal energy, biodiesel, biomass and so on). In the present study, raw neem oil was taken and converted into biodiesel using transesterification process. Nature based antioxidant namely ginger extract (Zingiber officinale Rosc.) was used as an antioxidant instead of synthetic antioxidants. An anti-oxidants were added in various proportions like G5 (0.5% additive), G10 (1% additive) and G15 (1.5% additive) with B20 (20% neem oil methyl ester with 80% diesel). B20G15 sample showed higher induction period than other samples. Thus, it was considered as an optimum blend with oxidation stability test using Rancimat instrument. Diesel showed higher Brake Thermal Efficiency (BTE) than biodiesel samples. On the other hand, B20G15 showed higher BTE than B20. Higher CO, HC and smoke emissions were observed for B20 with an antioxidant than other fuel samples. B20 with an antioxidant showed lower NOx emissions than diesel and B20. Thus, the nature based antioxidant was considered as the most promising alternative for NOx emission reduction.

  10. A COMPARATIVE STUDY OF OXYTOCIN/MISOPROSTOL/METHYLERGOMETRINE FOR ACTIVE MANAGEMENT OF THE THIRD STAGE OF LABOUR

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    Mundlapaty Sabitha

    2017-08-01

    Full Text Available BACKGROUND The third stage of labour is indeed the unforgiving stage of the labour and in it lurks more unheralded treachery than in both the other stages of labour combined. Many lifesaving drugs have been discovered and used for the management of this stage of labour. According to the WHO multicentric randomised trial using oral misoprostol with oxytocic, they concluded that oral misoprostol was associated with significantly high incidence of side effects like shivering and rise in body temperature and hence oxytocin is preferred to 600 mg of oral misoprostol in management of 3rd stage of labour in hospital settings, but still misoprostol has been suggested for the management of third stage of labour in developing countries, because it has strong uterotonic effects, can be given orally, inexpensive and does not need refrigeration. The aim of the study is to compare oxytocin, misoprostol, methylergometrine for active management of the third stage of labour. MATERIALS AND METHODS A total of 300 women of 37 weeks to 42 weeks of gestation delivering vaginally in Konaseema Institute of Medical Sciences, Amalapuram, Andhra Pradesh. 300 women allocated into 3 groups of 100 each to receive 10 IU I.M. oxytocin, 600 mcg sublingual misoprostol or 200 mcg I.M. methylergometrine, respectively. Primary outcome measure was blood loss in the third stage of labor; secondary measures were duration of the third stage, side effects and complications. RESULTS Subjects who received 600 mcg of misoprostol had the least blood loss (113 mL, followed by oxytocin and methylergometrine. The shortest mean duration of the third stage was with misoprostol (4.34 mins.. Shivering and pyrexia were observed in misoprostol group and raised blood pressure in methylergometrine group. CONCLUSION Misoprostol is as effective as oxytocin and both are more effective than methylergometrine in active management of the third stage of labour. Misoprostol therefore can be used in places

  11. Review of SQUID Sensors for Measuring Magnetocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. H.; Kim, J. M.; Yu, K. K.; Kim, K.; Kwon, H. [Brain and Cognition Measurement Lab, Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2011-08-15

    Measurement of magnetic signals generated from electric activity of myocardium provides useful information for the functional diagnosis of heart diseases. Key technical component of the magnetocardiography (MCG) technology is SQUID. To measure MCG signals with high signal-to-noise ratio, sensitive SQUID magnetic field sensors are needed. Present magnetic field sensors based on Nb SQUIDs have field sensitivity good enough to measure most of MCG signals. However, for accurate measurement of fine signal pattern or detection of local atrial fibrillation signals, we may need higher field sensitivity. In addition to field sensitivity, economic aspect of the SQUID system is also important. To simplify the SQUID readout electronics, the output voltage or flux-to-voltage transfer of SQUID should be large enough so that direct measurement of SQUID output can be done using room-temperature preamplifiers. Double relaxation oscillation SQUID (DROS), having about 10 times larger flux-to-voltage transfers than those of DC-SQUIDs, was shown to be a good choice to make the electronics compact. For effective cancellation of external noise inside a thin economic shielded room, first-order axial gradiometer with high balance, simple structure and long-baseline is needed. We developed a technology to make the axial gradiometer compact using direct bonding of superconductive wires between pickup coil and input coil. Conventional insert has mechanical support to hold the gradiometer array, and the dewar neck has equal diameter with the dewar bottom. Boiling of the liquid He can generate mechanical vibrations in the gradiometer array due to mechanical connection structure. Elimination of the mechanical support, and direct mounting of the gradiometer array into the dewar bottom can reduce the dewar neck diameter, resulting in the reduction of liquid He consumption.

  12. COMPARISON OF MISOPROSTOL AND MISOPROSTOL WITH ISOSORBIDE MONONITRATE IN SECOND TRIMESTER TERMINATION OF PREGNANCY

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    Shanthi Sivakumar

    2016-08-01

    Full Text Available BACKGROUND To compare the efficacy and side effect profile of vaginal misoprostol versus misoprostol and isosorbide mononitrate in enhancing cervical ripening in second trimester pregnancy termination. METHODS It is a random clinical trial done in 100 patients for mid trimester termination of pregnancy (between 12 and 24 weeks of gestational age. They were divided into two groups: Group A Combination of 400 mcg of misoprostol and 40 mg of ISMN placed intravaginally. Repeat doses included combination of 400 mcg of misoprostol and 20 mg of ISMN every 4 hours for maximum 4 doses. Group B 400 mcg of misoprostol placed intravaginally every 4 hours for maximum 4 doses for termination. In both the above-mentioned groups, T. mifepristone 600 mg was given orally 36-48 hrs. prior to termination. RESULTS The mean induction abortion interval was significantly less (7 hrs. 36 mins in Group A compared with group B (9 hrs. 55 min. There was no statistical significant difference in the amount of mean dose used in both groups. The complete abortion rate within 48 hrs. in Group A was 94%, which shows no statistical significance when compared with Group B complete abortion rates (80%. However, it is interpreted that on adding ISMN, the number of complete abortion rates are higher. There was no failure of abortion in both the groups. The side effects such as pain abdomen and fever were less in Group A (38% when compared to Group B (78%. CONCLUSION Vaginally administered ISMN seems to be safe and effective method in second trimester pregnancy termination. There is a reduction in hospital stay, manpower, economy spent on patient, and a sense of wellbeing from the patient also.

  13. A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA.

    Science.gov (United States)

    Keiser, Paul B; Gibbs, Barnett T; Coster, Trinka S; Moran, E Ellen; Stoddard, Mark B; Labrie, Joseph E; Schmiel, Deborah H; Pinto, Valerian; Chen, Ping; Zollinger, Wendell D

    2010-10-08

    This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one of the three dose groups (25 mcg, 25 mcg with aluminum hydroxide adjuvant, and 50 mcg) to receive three intramuscular injections at 0, 6 and 24 weeks. Specific local and systemic adverse events (AEs) were solicited by diary and at visits on days 1, 2, 7 and 14 after each vaccination and at the end of the study at 30 weeks. Blood chemistries, complete blood count, and coagulation studies were measured on each vaccination day and again two days later. Blood for antibody measurements and bactericidal assays were drawn 0, 14, and 42 days after each vaccination. The proportion of volunteers who developed a fourfold or greater increase in serum bactericidal activity (SBA) to the wild-type parent of the vaccine strain with high opcA expression at 6 weeks after the third dose was 12/26 (0.46, 95% confidence interval 0.27-0.65). Antibody levels to OpcA were significantly higher in vaccine responders than in non-responders (p=0.008), and there was a trend for higher antibody levels to the lipooligosaccharide (LOS) (p=0.059). Bactericidal depletion assays on sera from volunteers with high-titer responses also indicate a major contribution of anti-OpcA and anti-LOS antibodies to the bactericidal response.These results suggest that genetically modified NOMV vaccines can induce protection against group B meningococcus. Copyright © 2010 Elsevier Ltd. All rights reserved.

  14. Melatonin’s Effect on the Efficacy of Desmopressin in the Treatment of Enuresis

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    Pietro Ferrara

    2016-09-01

    Full Text Available Purpose This study aims to evaluate and compare the efficacy of exogenous melatonin associated with desmopressin (dDAVP and dietary recommendations. Methods A total of 189 patients were enrolled from the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome, from January 2013 to June 2015. Of the 189 original patients, 153 children, aged between 5 and 14 years (mean age, 8.7 years were included in the study. After clinical evaluation and a 3-month period of observation without treatment, children were assigned to receive treatment in one of 3 groups: group 1, dDAVP at a dose of 120 mcg a day (Minirin; group 2, dDAVP at a dose of 120 mcg and dietary recommendations; or group 3, dDAVP at a dose of 120 mcg, dietary recommendations, and melatonin at a dose of 1 mg a day (Melamil plus. Each patient was treated for 3 months. Results After the 3 months of therapy, a desiderable response was achieved in 30 of 51 patients (58.82% treated with dDAVP, 35 of 53 patients (66.04% treated with dDAVP and dietary recommendations, and 35 of 49 patients (71.43% treated with dDAVP, dietary recommendations, and melatonin. Conclusions Although not statistically significant, the results show that the association between dDAVP treatment with dietary recommendations and melatonin could be considered a safe and effective treatment of NE. Considering that the statistically insignificant results might be due to the small sample size, the study will be continued to increase the number of subjects.

  15. Oral triiodothyronine normalizes triiodothyronine levels after surgery for pediatric congenital heart disease*.

    Science.gov (United States)

    Marwali, Eva M; Boom, Cindy E; Sakidjan, Indriwanto; Santoso, Anwar; Fakhri, Dicky; Kartini, Ay; Kekalih, Aria; Schwartz, Steven M; Haas, Nikolaus A

    2013-09-01

    This study was conducted to determine if oral triiodothyronine supplementation could prevent the decrease of serum triiodothyronine levels that commonly occurs after cardiopulmonary bypass for pediatric congenital heart surgery. Secondary objectives included identifying any significant adverse effects of oral triiodothyronine supplementation, including any effects on the thyroid/pituitary axis. Randomized, placebo-controlled, doubleblind clinical trial Operating room and ICU. Infants and children younger than 2 years of age undergoing congenital heart surgery using cardiopulmonary bypass (n = 43). Subjects were assigned to placebo (n = 15, group A) or one of two treatment groups: a low-dose group (group B, n = 14, 0.5 mcg/kg triiodothyronine orally every 24 hr for 3 d) or a high-dose group (group C, n = 14, 0.5 mcg/kg triiodothyronine orally every 12 hr for 3 d). Thyroid hormone, including total and free triiodothyronine levels at predetermined time points, potential side effects indicating hyperthyroidism, indicators of the thyroid-pituitary axis, and clinical endpoints. Oral triiodothyronine supplementation twice-daily maintained serum triiodothyronine levels within normal limits in group C, whereas serum levels progressively declined in groups A and B. A statistically significant difference in triiodothyronine levels between the treatment groups occurred between 18 and 36 hours post cross-clamp release, with the largest difference in serum levels between group C and group A noted at 36 hours post cross-clamp release (total triiodothyronine, 0.71 ± 0.15 [0.34-1.08] ng/mL [p triiodothyronine, 2.56 ± 0.49 [1.33-3.79] pg/mL [p triiodothyronine supplementation at a dose of 0.5 mcg/kg every 12 hours for 3 days can maintain total and free triiodothyronine levels within normal limits after open-heart surgery using cardiopulmonary bypass for congenital heart disease.

  16. Metabolic engineering of potato carotenoid content through tuber-specific overexpression of a bacterial mini-pathway.

    Directory of Open Access Journals (Sweden)

    Gianfranco Diretto

    Full Text Available BACKGROUND: Since the creation of "Golden Rice", biofortification of plant-derived foods is a promising strategy for the alleviation of nutritional deficiencies. Potato is the most important staple food for mankind after the cereals rice, wheat and maize, and is extremely poor in provitamin A carotenoids. METHODOLOGY: We transformed potato with a mini-pathway of bacterial origin, driving the synthesis of beta-carotene (Provitamin A from geranylgeranyl diphosphate. Three genes, encoding phytoene synthase (CrtB, phytoene desaturase (CrtI and lycopene beta-cyclase (CrtY from Erwinia, under tuber-specific or constitutive promoter control, were used. 86 independent transgenic lines, containing six different promoter/gene combinations, were produced and analyzed. Extensive regulatory effects on the expression of endogenous genes for carotenoid biosynthesis are observed in transgenic lines. Constitutive expression of the CrtY and/or CrtI genes interferes with the establishment of transgenosis and with the accumulation of leaf carotenoids. Expression of all three genes, under tuber-specific promoter control, results in tubers with a deep yellow ("golden" phenotype without any adverse leaf phenotypes. In these tubers, carotenoids increase approx. 20-fold, to 114 mcg/g dry weight and beta-carotene 3600-fold, to 47 mcg/g dry weight. CONCLUSIONS: This is the highest carotenoid and beta-carotene content reported for biofortified potato as well as for any of the four major staple foods (the next best event being "Golden Rice 2", with 31 mcg/g dry weight beta-carotene. Assuming a beta-carotene to retinol conversion of 6ratio1, this is sufficient to provide 50% of the Recommended Daily Allowance of Vitamin A with 250 gms (fresh weight of "golden" potatoes.

  17. Comparison of rocuronium and succinylcholine on postintubation sedative and analgesic dosing in the emergency department.

    Science.gov (United States)

    Korinek, Justin D; Thomas, Rachel M; Goddard, Luke A; St John, Alexander E; Sakles, John C; Patanwala, Asad E

    2014-06-01

    Rocuronium and succinylcholine are both commonly used neuromuscular blockers for rapid sequence intubation in the emergency department (ED). The objective of this study was to determine if patients who receive rocuronium are more likely to receive lower doses of postintubation sedatives and analgesics compared with patients who receive succinylcholine. This was a retrospective cohort study carried out in a tertiary, academic ED. Consecutive adult patients, who were intubated using etomidate for induction of sedation, were included. Patients were categorized on the basis of whether they received (a) rocuronium or (b) succinylcholine for paralysis. The dosing of postintubation sedative and analgesic infusions were compared 30 min after initiation between the two groups. A total of 254 patients were included in the final analysis (rocuronium=127 and succinylcholine=127). In the overall cohort, 90.2% (n=229) of patients were administered a sedative postintubation in the ED. Most of these patients were initiated on propofol infusions. The mean propofol infusion rate at 30 min was 30±23 mcg/kg/min in the rocuronium group and 42±24 mcg/kg/min in the succinylcholine group (P=0.002). A total of 42.5% of patients (n=108) received an analgesic infusion (all patients received fentanyl). The mean fentanyl infusion rate at 30 min was 0.65±0.55 and 0.86±0.49 mcg/kg/h in the rocuronium and succinylcholine groups, respectively (P=0.041). Patients who receive rocuronium are more likely to receive lower doses of sedative and analgesic infusions after intubation. This may place them at risk of being awake under paralysis.

  18. A novel needle for subcutaneous injection of interferon beta-1a: effect on pain in volunteers and satisfaction in patients with multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Prais Wes A

    2008-10-01

    Full Text Available Abstract Background To reduce injection pain and improve satisfaction, a thinner (29-gauge [29G], sharper (5-bevel needle than the 27G/3-bevel needle used previously to inject interferon (IFN beta-1a, 44 or 22 mcg subcutaneously (sc three times weekly (tiw, was developed for use in multiple sclerosis (MS. Methods Two clinical trials in healthy volunteers and five surveys of patients with MS were conducted to assess whether the 29G/5-bevel needle with a Thermo Plastic Elastomer (TPE needle shield (a sleeve that houses the tip of the needle in a secure location is an improvement over the 27G/3-bevel needle with a rubber shield for injection of IFN beta-1a, 44 or 22 mcg sc tiw. Parameters assessed were: pain and ease of insertion (healthy volunteer and nurse responses on subjective pain measurement scales; and patient satisfaction (surveys of patients with MS. Results In healthy volunteers, the 29G/5-bevel needle with TPE shield was associated with the least perceived pain on the Visual Analog Scale (VAS and Verbal VAS (VB-VAS; mean VAS pain scores decreased by 40% and skin penetration improved by 69% compared with the 27G/3-bevel needle with standard rubber shield (p Conclusion Together these studies indicate that the 29G/5-bevel needle with the TPE shield is an improvement over the 27G/3-bevel needle with standard rubber shield in terms of pain, ease of insertion and patient satisfaction. These improvements are expected to result in improved compliance in patients with MS treated with IFN beta-1a, 44 or 22 mcg sc tiw.

  19. A fatal case of thallium toxicity: challenges in management.

    Science.gov (United States)

    Riyaz, R; Pandalai, S L; Schwartz, M; Kazzi, Z N

    2013-03-01

    Thallium is a highly toxic compound and is occasionally involved in intentional overdoses or criminal poisonings. Accidental poisonings also occur, but are increasingly rare owing to restricted use and availability of thallium. We report a fatal suicidal ingestion of thallium sulfate rodenticide in which multi-dose activated charcoal (MDAC) and Prussian Blue (PB) were both used without changing the outcome. A 36 year old man ingested an unknown amount of thallium sulfate grains from an old rodenticide bottle. He presented to an emergency department (ED) 45 minutes later with abdominal pain and vomiting. On examination he was agitated with a blood pressure of 141/60 mmHg and a heart rate of 146 beats per minute (bpm). He received MDAC during his initial ED management and was started on PB 18 hours post arrival; he was intubated on the following day for airway protection. The patient continued to be tachycardic and hypertensive and subsequently developed renal failure. On hospital day three, the patient developed hypotension that did not respond to fluids. The patient required vasopressors and was transferred to a tertiary care center to undergo continuous renal replacement therapy (CRRT). The patient died shortly after his transfer. His last blood thallium concentration was 5369 mcg/L, a spot urine thallium >2000 mcg/L, and a 24- hour urine thallium was >2000 mcg/L. Though extremely rare, thallium intoxication can be lethal despite early administration of MDAC and use of Prussian blue therapy. Rapid initiation of hemodialysis can be considered in cases of severe thallium poisoning, to remove additional thallium, to correct acid-base disturbance, or to improve renal function.

  20. Central motor control failure in fibromyalgia: a surface electromyography study.

    Science.gov (United States)

    Casale, Roberto; Sarzi-Puttini, Piercarlo; Atzeni, Fabiola; Gazzoni, Marco; Buskila, Dan; Rainoldi, Alberto

    2009-07-01

    Fibromyalgia (FM) is characterised by diffuse musculoskeletal pain and stiffness at multiple sites, tender points in characteristic locations, and the frequent presence of symptoms such as fatigue. The aim of this study was to assess whether the myoelectrical manifestations of fatigue in patients affected by FM are central or peripheral in origin. Eight female patients aged 55.6 +/- 13.6 years (FM group) and eight healthy female volunteers aged 50.3 +/- 9.3 years (MCG) were studied by means of non-invasive surface electromyography (s-EMG) involving a linear array of 16 electrodes placed on the skin overlying the biceps brachii muscle, with muscle fatigue being evoked by means of voluntary and involuntary (electrically elicited) contractions. Maximal voluntary contractions (MVCs), motor unit action potential conduction velocity distributions (mean +/- SD and skewness), and the mean power frequency of the spectrum (MNF) were estimated in order to assess whether there were any significant differences between the two groups and contraction types. The motor pattern of recruitment during voluntary contractions was altered in the FM patients, who also showed fewer myoelectrical manifestations of fatigue (normalised conduction velocity rate of changes: -0.074 +/- 0.052%/s in FM vs -0.196 +/- 0.133%/s in MCG; normalised MNF rate of changes: -0.29 +/- 0.16%/s in FM vs -0.66 +/- 0.34%/s in MCG). Mean conduction velocity distribution and skewnesses values were higher (p fatigue in FM is the electrophysiological expression of muscle remodelling in terms of the prevalence of slow conducting fatigue-resistant type I fibres. As the only between-group differences concerned voluntary contractions, they are probably more related to central motor control failure than muscle membrane alterations, which suggests pathological muscle fibre remodelling related to altered suprasegmental control.

  1. Exploring the feasibility of obtaining mifepristone and misoprostol from the internet.

    Science.gov (United States)

    Murtagh, Chloe; Wells, Elisa; Raymond, Elizabeth G; Coeytaux, Francine; Winikoff, Beverly

    2018-04-01

    We aimed to document the experience of buying abortion pills from online vendors that do not require a prescription and to evaluate the active ingredient content of the pills received. We searched the internet to identify a convenience sample of websites that sold mifepristone and misoprostol to purchasers in the United States and attempted to order these products. We documented price, shipping time and other aspects of ordering. We sent the samples received to a testing laboratory that measured the amount of active ingredient in individual tablets. We identified 18 websites and ordered 22 products: 20 mifepristone-misoprostol combination products and 2 that contained only misoprostol. We received 18 combination products and the 2 misoprostol products from 16 different sites. No site required a prescription or any relevant medical information. The time between order and receipt of the 20 products ranged from 3 to 21 business days (median 9.5 days). The price for the 18 combination products ranged from $110 to $360, including shipping and fees; the products without mifepristone cost less. Chemical assays found that the 18 tablets labeled 200 mg mifepristone contained between 184.3 mg and 204.1 mg mifepristone, while the 20 tablets labeled 200 mcg misoprostol contained between 34.1 mcg and 201.4 mcg of the active ingredient. Obtaining abortion medications from online pharmaceutical websites is feasible in the United States. The mifepristone tablets received contained within 8% of the labeled amount of active agent. The misoprostol tablets all contained that compound but usually less than labeled. Given our findings, we expect that some people for whom clinic-based abortion is not easily available or acceptable may consider self-sourcing pills from the internet to be a rational option. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Short-term response of bone turnover to low-dose oral contraceptives in exercising women with hypothalamic amenorrhea.

    Science.gov (United States)

    Vescovi, Jason D; VanHeest, Jaci L; De Souza, Mary Jane

    2008-02-01

    We examined the response of bone turnover markers and indices of energy status after 2 weeks of oral contraceptive (OC) therapy in premenopausal women with exercise-associated menstrual disturbances (EAMD). Six women with EAMD received one 28-day cycle of a triphasic OC containing 180-250 mcg norgestimate/25 mcg ethinyl estradiol (EAMD+OC) and six were controls (EAMD controls). Bone turnover markers amino-terminal propeptide of Type I procollagen and serum carboxy-terminal telopeptides of Type I collagen (PINP and SCTX-I) were assessed at baseline and after 2 weeks of OC therapy (EAMD+OC) or after a 30-day monitoring period (EAMD controls). Total triiodothyronine, resting energy expenditure (REE) and dietary intake were assessed as secondary end points. The absolute and percent changes from baseline in the primary and secondary outcomes were evaluated using an analysis of covariance, adjusting for baseline values of the corresponding outcome. Compared to EAMD controls, a significant change from baseline was observed in the EAMD+OC group for PINP (mean+/-SEM, 9.9+/-6.1 vs. -33.9+/-9.0 mcg/L; p=.005) and SCTX-I (-0.02+/-0.11 vs. -0.25+/-0.07 ng/mL; p=.017), but not osteoprotegerin (-0.53+/-0.22 vs. 0.20+/-0.44 pmol/L; p=.429) after 2 weeks (14.7+/-0.3 days) of OC therapy. Total triiodothyronine levels were elevated in the EAMD+OC group after therapy compared with EAMD controls (19.7+/-4.1 vs. -8.4+/-4.9 ng/dL; p=.002); however, no differences between groups were observed for the changes in REE or dietary intake. Our data demonstrate that 2 weeks of low-dose OC therapy rapidly reduced markers of bone resorption and formation, without any significant impact on energy status in women with EAMD.

  3. Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial.

    Directory of Open Access Journals (Sweden)

    Eric J Tarcha

    Full Text Available Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases, including psoriasis.The primary objective was to evaluate the safety of repeat doses of dalazatide in adult patients with mild-to-moderate plaque psoriasis. Secondary objectives were to evaluate clinical proof of concept and the effects of dalazatide on mediators of inflammation in the blood and on chronically activated memory T cell populations.Patients (n = 24 were randomized 5:5:2 to receive dalazatide at 30 mcg/dose, 60 mcg/dose, or placebo twice weekly by subcutaneous injection (9 doses total. Safety was assessed on the basis of physical and neurological examination and laboratory testing. Clinical assessments included body-surface area affected, Psoriasis Area and Severity Index (PASI, and investigator and patient questionnaires.The most common adverse events were temporary mild (Grade 1 hypoesthesia (n = 20; 75% placebo, 85% dalazatide and paresthesia (n = 15; 25% placebo, 70% dalazatide involving the hands, feet, or perioral area. Nine of 10 patients in the 60 mcg/dose group had a reduction in their PASI score between baseline and Day 32, and the mean reduction in PASI score was significant in this group (P < 0.01. Dalazatide treatment reduced the plasma levels of multiple inflammation markers and reduced the expression of T cell activation markers on peripheral blood memory T cells.The study was small and drug treatment was for a short duration (4 weeks.This study indicates that dalazatide is generally well tolerated and can improve psoriatic skin lesions by modulating T cell surface and activation marker expression and inhibiting mediators of inflammation in the blood. Larger studies of longer duration are warranted.

  4. Activation of the polyol pathway may contribute to increased risk of radiocontrast agent nephrotoxicity in diabetes

    International Nuclear Information System (INIS)

    Kaplan, D.L.; Mann, P.L.; Zager, P.G.; Smith, M.A.

    1991-01-01

    The incidence of radiocontrast (RC) agent nephrotoxicity is higher in diabetic than non-diabetic patients. RC nephropathy involves both glomerular and tubular cells. The authors postulate that activation of the polyol pathway contributes to the increased susceptibility of diabetics to RC nephrotoxicity. Mesangial cells modulate GFR by altering the capillary surface area available for filtration. Toxic insult to mesangial cells can impair glomerular function. The present study was performed to determine if mesangial cells isolated from galactose fed rats, the classic model for studying the effects of polyol accumulation, demonstrate increased susceptibility to RC toxicity. A cellular model was developed to study the effects of RC agents on mesangial cells isolated from rats maintained on diets of 50% galactose (MCG) and 50% dextrin (MCD). MCG's and MCD's were plated in 96 well trays at a density of 6.25 x 10 4 cells/ml. Cells were exposed to Hypaque 90 at concentrations of 10 mM to 1 uM for 1, 2, 4 and 24 hrs. Cell viability was determined by fluorescein diacetate/propidium iodide staining. 3H-thymidine incorporation was used to determine cell proliferation rates. Hypaque 90 produced no direct cytotoxicity at any time points or concentrations tested. An increase in cell proliferation was observed 1 hr after exposure to 1 uM to 1mM Hypaque. Higher concentrations blunted cell proliferation rates. Hypaque 90 produced no direct cytotoxicity at any time points or concentrations tested. An increase in cell proliferation was observed 1 hr after exposure to 1 uM to 1mM Hypaque. Higher concentrations blunted cell proliferation. No significant effects on 3H-thymidine incorporation were observed at later time points. The effects on 3H-thymidine incorporation were more pronounced in MCG's than MCD's. Activation of the polyol pathway amplifies the proliferative response of MC to RC agents. This activation may contribute to the risk of RC nephropathy in diabetics

  5. The enhancement of hemodynamic performance in Fontan circulation using pain free spontaneous ventilation.

    Science.gov (United States)

    Lofland, G K

    2001-07-01

    Positive pressure ventilation is known to have a deleterious effect on pulmonary blood flow in patients with Fontan physiology. We evaluated the hemodynamic effects of pain free, spontaneous, non-positive pressure ventilation in patients undergoing Fontan staging procedures or completion. Fontan procedures, with creation of low pressure passive pulmonary circulation. Between May 1997 and May 1999 50 consecutive patients undergoing either bi-directional Glenn (BDG, n=23) or completion Fontan (n=27), were managed with early extubation. Anaesthetic management included continuous narcotics, caudal block, epidural block, or hyperbaric spinal. Post-operative management included low dose dopamine (3 mcg/kg per min), nitro-glycerine (0.3 mcg/kg per min) and nitroprusside (0.3 mcg/kg per min). Post-operative management was identical for all patients. Twelve patients were randomly selected to undergo continuous cardiac output and cardiac index (CI) determinations utilizing extra vascular Doppler probes placed on the ascending aorta, allowing for continuous aortic diameter and Doppler wave form velocity recordings. All patients were extubated either in the operating room or within one hour post-operatively. There were no deaths and no complications in the series. Mean length of stay (LOS) for BDG was 4.3+/-0.5 days. Mean LOS for Fontan patients was 11+/-4 days. Mean pulmonary artery pressure (MPAP) fell from 19+/-3.464 pre-extubation to 14+/-3.271 immediately post-extubation, 13.2+/-2.261 6 h post-extubation, and 11.7+/-2.146 12 h post-extubation. All decreases in MPAP post-extubation were significant (P=post-extubation 5.05+/-1.297, 12 h post-extubation 6.225+/-1.19. All increases in CI post-extubation were significant (P=pain free, spontaneous, non-positive pressure ventilation enhances hemodynamic performance in patients with Fontan circulation and clearly improves outcome.

  6. Chorea--an unusual manifestation in a woman recovering from myxedema coma.

    Science.gov (United States)

    Yu, Catherine H Y; Stovel, Rebecca; Fox, Susan

    2012-01-01

    To report a case of reversible chorea in a woman with myxedema coma. We describe the clinical course, imaging findings, and laboratory test results of a patient who initially presented with myxedema coma and then developed reversible chorea upon treatment. A 33-year-old woman with a known history of primary hypothyroidism presented with a 3-week history of lethargy, progressing to a precipitous decline in consciousness that required intubation. Physical examination revealed concurrent hypothermia and bradycardia. Laboratory investigations demonstrated a thyrotropin concentration greater than 100 mIU/L, a free triiodothyronine concentration of 1.9 pg/mL, and a free thyroxine concentration of 0.24 ng/dL, but no other metabolic abnormalities. She was treated with intravenous levothyroxine therapy on the first 2 days of hospital admission (200 mcg and 250 mcg, respectively). On day 2, she was obeying commands and she was extubated. She began exhibiting choreiform movements. Thyroid function test results revealed a normal free thyroxine concentration (1.10 ng/dL), but an elevated thyrotropin concentration (40.98 mIU/L) and a low free triiodothyronine concentration (1.9 pg/mL). Findings from computed tomography and magnetic resonance imaging of her brain and analysis of cerebrospinal fluid were normal. Her regimen was transitioned to oral levothyroxine, 88 mcg daily, and by day 4, her choreiform movements ceased. Neurologic manifestations of hypothyroidism include psychomotor slowing, memory deficits, and dementia, with myxedema coma at the extreme of this spectrum. Although chorea is a rare manifestation of hyperthyroidism, this is the first report of a patient with acquired, reversible choreiform movement disorder while still being severely hypothyroid and treated with levothyroxine.

  7. Effects of antioxidant additives on engine performance and exhaust emissions of a diesel engine fueled with canola oil methyl ester–diesel blend

    International Nuclear Information System (INIS)

    İleri, Erol; Koçar, Günnur

    2013-01-01

    Highlights: • BHA, BHT, TBHQ, EHN synthetic antioxidants were employed in the study. • Antioxidant additives are a promising candidate for improving cetane number, oxidation stability and decreasing NO x emissions • Cetane number improving efficiency of the antioxidants was ordered as EHN>BHA>BHT>TBHQ. • Formation of CO emissions has been increased with addition of each of the antioxidants to B20. - Abstract: An experimental investigation has been carried out to analyze the effect of antioxidants on engine performance and exhaust emissions of a diesel engine fueled with B20 (20 vol.% canola oil methyl ester and 80 vol.% diesel fuel blend). The four synthetic antioxidants, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tert-butylhydroquinone (TBHQ) and 2-ethylhexyl nitrate (EHN), were tested on a Land Rover turbocharged direct injection (TDI) 110 type diesel engine with water cooled, 4-cycl and 4-cylinder. The addition of antioxidants to B20 did not cause any negative effect on basic fuel properties of B20. According to engine performance test results, brake specific fuel consumption (BSFC) of B20 with antioxidants decreased compared to those of B20 without antioxidants. A 1000 ppm concentration of TBHQ was optimal as BSFC values were considerably reduced (10.19%) in the whole engine speeds when compared to B20. EHN antioxidant with B20 presented the best mean oxides of nitrogen (NO x ) with a reduction of 4.63%. However, formation of carbon monoxide (CO) emissions has been increased with addition of each of the antioxidants to B20

  8. Radiochemical analysis of Bikini ashes fallen on board the No. 5 Fukuryu Maru on March 1, 1954

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, K

    1954-01-01

    Comprehensive analysis was done in order to find the proper method of medical treatment for the victim fishermen on board. Analysis was started on March 18, and ash was found to consist mostly of Ca(OH)/sub 2/, activity of which was 0.37 mc/g on April 23. Cations of the 3rd group (especially rare-earth metals) and 5th group were found to have strong activity by chemical separation. Fractions of each group, anions, Zr and Nb fraction, and U fraction were separated by an ion-exchange method.

  9. Granulocyte-colony stimulating factor (G-CSF)-primed, delayed marrow harvests as a source of hematopoietic stem and progenitor cells for allogeneic transplantation.

    Science.gov (United States)

    Phillips, G L; Davey, D D; Hale, G A; Marshall, K W; Munn, R K; Nath, R; Reece, D E; Van Zant, G

    1999-10-01

    We evaluated the ability of G-CSF to increase the number of hematopoietic stem cells obtained by "delayed" BM harvest for allogeneic transplantation. Five normal donors received G-CSF @ 10 mcg/kg/day x 5 followed by repeat PB and BM assays at day 6 and 16, and BM harvest at day 16. Stem cells were not increased in the BM at day 16. Five patients underwent BMT and engrafted at +10 to +19 days. While the tested strategy offers no intrinsic advantages, its potential cannot be evaluated fully without alternative timing and/or additional, "early acting" growth factors.

  10. Effects of Current Guides Destruction at Ultra-fast Acceleration of Macrobodies

    Science.gov (United States)

    Kataev, V. N.; Boriskin, A. S.; Golosov, S. N.; Demidov, V. A.; Klimashov, M. V.; Korolev, P. V.; Makartsev, G. F.; Pikar, A. S.; Russkov, A. S.; Shapovalov, E. V.; Shibitov, Yu. M.

    2006-08-01

    The paper is devoted to discussion of current guides destruction effects in different accelerators: thermal-electric and electro-magnetic rail accelerator at macrobodies acceleration value of 108-109 m/s2. Experimental results with thermal-electric accelerators powering from megajoule capacitor battery and helical magneto-cumulative generator MCG-100 at currents up to 3.5 MA are analyzed. The process of rails destruction at railgun at pressure magnetic field excess over the limit of metal fluidity is presented. Methods of efficiency coefficient increase of capacitive storage energy transmission to kinetic energy of accelerating body are discussed.

  11. [Effect of activation and blockade of the GABA-ergic system of the substantia nigra in the midbrain on the realization of conditioned food reflexes in dogs].

    Science.gov (United States)

    Iakimovskiĭ, A F

    1988-01-01

    Bilateral injection of 45 mcg of GABA into substantia nigra pars compacta produced in dogs a manifested improvement of parameters of the conditioned differentiation inhibition but failed to influence the positive Pavlovian alimentary conditioned reflex. Injection of GABA synaptic antagonist--picrotoxin impaired conditioned alimentary behaviour. Numerous injections of the GABAergic pharmacological agents resulted in motor disturbance--rotatory movements--and skin trophic deviations. The data obtained and literature references give ground for discussion of the role of striato-nigral and internal GABAergic substantia nigra systems in the positive modulation of adaptive alimentary behaviour and conditioned stimuli differentiation.

  12. The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor

    Directory of Open Access Journals (Sweden)

    Zahit Çeker

    2015-02-01

    Full Text Available BACKGROUND AND OBJECTIVES: The importance of minimizing the exaggerated sympatho-adrenergic responses and QT interval and QT interval dispersion changes that may develop due to laryngoscopy and tracheal intubation during anesthesia induction in the hypertensive patients is clear. Esmolol decreases the hemodynamic response to laryngoscopy and intubation. However, the effect of esmolol in decreasing the prolonged QT interval and QT interval dispersion as induced by laryngoscopy and intubation is controversial. We investigated the effect of esmolol on the hemodynamic, and corrected-QT interval and corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients using angiotensin converting enzyme inhibitors. METHODS: 60 ASA I-II patients, with essential hypertension using angiotensin converting enzyme inhibitors were included in the study. The esmolol group received esmolol at a bolus dose of 500 mcg/kg followed by a 100 mcg/kg/min infusion which continued until the 4th min after intubation. The control group received 0.9% saline similar to the esmolol group. The mean blood pressure, heart rate values and the electrocardiogram records were obtained as baseline values before the anesthesia, 5 min after esmolol and saline administration, 3 min after the induction and 30 s, 2 min and 4 min after intubation. RESULTS: The corrected-QT interval was shorter in the esmolol group (p = 0.012, the corrected-QT interval dispersion interval was longer in the control group (p = 0.034 and the mean heart rate was higher in the control group (p = 0.022 30 s after intubation. The risk of arrhythmia frequency was higher in the control group in the 4-min period following intubation (p = 0.038. CONCLUSION: Endotracheal intubation was found to prolong corrected-QT interval and corrected-QT interval dispersion, and increase the heart rate during anesthesia induction with propofol in hypertensive patients using angiotensin converting

  13. [The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor].

    Science.gov (United States)

    Ceker, Zahit; Takmaz, Suna Akın; Baltaci, Bülent; Başar, Hülya

    2015-01-01

    The importance of minimizing the exaggerated sympatho-adrenergic responses and QT interval and QT interval dispersion changes that may develop due to laryngoscopy and tracheal intubation during anesthesia induction in the hypertensive patients is clear. Esmolol decreases the hemodynamic response to laryngoscopy and intubation. However, the effect of esmolol in decreasing the prolonged QT interval and QT interval dispersion as induced by laryngoscopy and intubation is controversial. We investigated the effect of esmolol on the hemodynamic, and corrected-QT interval and corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients using angiotensin converting enzyme inhibitors. 60 ASA I-II patients, with essential hypertension using angiotensin converting enzyme inhibitors were included in the study. The esmolol group received esmolol at a bolus dose of 500mcg/kg followed by a 100mcg/kg/min infusion which continued until the 4th min after intubation. The control group received 0.9% saline similar to the esmolol group. The mean blood pressure, heart rate values and the electrocardiogram records were obtained as baseline values before the anesthesia, 5min after esmolol and saline administration, 3min after the induction and 30s, 2min and 4min after intubation. The corrected-QT interval was shorter in the esmolol group (p=0.012), the corrected-QT interval dispersion interval was longer in the control group (p=0.034) and the mean heart rate was higher in the control group (p=0.022) 30s after intubation. The risk of arrhythmia frequency was higher in the control group in the 4-min period following intubation (p=0.038). Endotracheal intubation was found to prolong corrected-QT interval and corrected-QT interval dispersion, and increase the heart rate during anesthesia induction with propofol in hypertensive patients using angiotensin converting enzyme inhibitors. These effects were prevented with esmolol (500mcg/kg bolus, followed by

  14. Results from a study using misoprostol for management of incomplete abortion in Vietnamese hospitals: implications for task shifting.

    Science.gov (United States)

    Ngoc, Nguyen Thi Nhu; Shochet, Tara; Blum, Jennifer; Hai, Pham Thanh; Dung, Duong Lan; Nhan, Tran Thanh; Winikoff, Beverly

    2013-05-22

    Complications following spontaneous or induced abortion are a major cause of maternal morbidity. To manage these complications, post-abortion care (PAC) services should be readily available and easy to access. Standard PAC treatment includes surgical interventions that are highly effective but require surgical providers and medical centers that have the necessary space and equipment. Misoprostol has been shown to be an effective alternative to surgical evacuation and can be offered by lower level clinicians. This study sought to assess whether 400 mcg sublingual misoprostol could effectively evacuate the uterus after incomplete abortion and to confirm its applicability for use at lower level settings. All women presenting with incomplete abortion at one of three hospitals in Vietnam were enrolled. Providers were not asked to record if the abortion was spontaneous or induced. It is likely that all were spontaneous given the legal status and easy access to abortion services in Vietnam. Participants were given 400 mcg sublingual misoprostol and instructed to hold the pills under their tongue for 30 minutes and then swallow any remaining fragments. They were then asked to return one week later to confirm their clinical status. Study clinicians were instructed to confirm a complete expulsion clinically. All women were asked to complete a questionnaire regarding satisfaction with the treatment. Three hundred and two women were enrolled between September 2009 and May 2010. Almost all participants (96.3%) had successful completions using a single dose of 400 mcg misoprostol. The majority of women (87.2%) found the side effects to be tolerable or easily tolerable. Most women (84.3%) were satisfied or very satisfied with the treatment they received; only one was dissatisfied (0.3%). Nine out of ten women would select this method again and recommend it to a friend (91.0% and 90.0%, respectively). This study confirms that 400 mcg sublingual misoprostol effectively evacuates

  15. A Budget Impact Model of Hemophilia Bypassing Agent Prophylaxis Relative to Recombinant Factor VIIa On-Demand.

    Science.gov (United States)

    Mehta, Darshan A; Oladapo, Abiola O; Epstein, Joshua D; Novack, Aaron R; Neufeld, Ellis J; Hay, Joel W

    2016-02-01

    determine the number of bleeding episodes avoided. Based on the median on-demand dose of 695 mcg per kg per bleed, reported by the DOSE registry, the annual rFVIIa on-demand cost was $34,009 per kg of body weight. The annual rFVIIa on-demand cost was $22,020 per kg of body weight when the median dose of 450 mcg per kg per bleed reported by the HTRS registry was considered. The annual cost rose to $38,461 per kg of body weight when the rFVIIa on-demand dose of 786 mcg per kg per bleed among patients infusing an initial dose ≥ 250 mcg per kg was considered. The aPCC (85 units per kg per every other day) and rFVIIa (90 mcg per kg per every day) annual prophylaxis costs were $26,536 and $60,700, respectively. Also, aPCC and rFVIIa prophyaxis treatments were estimated to prevent a total of 20.8 and 12.9 annual bleeding episodes, respectively. When compared with the on-demand dose of 695 mcg per kg per bleed (DOSE registry), the annual aPCC and rFVIIa prophylaxis costs were 21.9% lower and 78.4% higher, respectively. Additionally, aPCC prophylaxis saved $360 per kg for each bleeding episode avoided. rFVIIa prophylaxis cost $2,066 per kg for each bleeding episode avoided. Compared with the on-demand dose of 450 mcg per kg per bleed (HTRS registry), aPCC and rFVIIa prophylaxis costs were 20.5% and 174.9% higher, respectively. In this case, aPCC and rFVIIa prophylaxis treatment costs were $217 per kg and $2,995 per kg, respectively, for each bleeding episode avoided. aPCC and rFVIIa prophylaxis costs were 31.0% lower and 57.8% higher, respectively, when compared with the rFVIIa on-demand dose of 786 mcg per kg per bleed, among patients infusing an initial dose ≥ 250 mcg per kg (HTRS registry). In this case, aPCC prophylaxis saved $573 per kg for each bleeding episode avoided, while rFVIIa prophylaxis costs $1,724 per kg for each bleeding episode avoided. Results of the 2-way sensitivity analyses were robust in the majority of the scenarios considered. aPCC prophylaxis may be

  16. Hidden Broad Line Seyfert 2 Galaxies in the CfA and 12micron Samples

    OpenAIRE

    Tran, Hien D.

    2001-01-01

    We report the results of a spectropolarimetric survey of the CfA and 12micron samples of Seyfert 2 galaxies (S2s). Polarized (hidden) broad line regions (HBLRs) are confirmed in a number of galaxies, and several new cases (F02581-1136, MCG -3-58-7, NGC 5995, NGC 6552, NGC 7682) are reported. The 12micron S2 sample shows a significantly higher incidence of HBLR (50%) than its CfA counterpart (30%), suggesting that the latter may be incomplete in hidden AGNs. Compared to the non-HBLR S2s, the H...

  17. Computer graphics and cultural heritage, part 2: continuing inspiration for future tools.

    Science.gov (United States)

    Arnold, David

    2014-01-01

    The availability of large quantities of cultural-heritage data will enable new, previously inconceivable, types of analysis and new applications. Currently, most emerging analysis methods are experimental research. It's likely to take many years before the research matures and provides cultural-heritage professionals with novel research methods that they use routinely. Indeed, we can expect further disruptive technologies to emerge in the foreseeable future and a "steady state" of continuing rapid change. Part 1 can be found at 10.1109/MCG.2014.47.

  18. Oxytetracycline in Pyoderma

    Directory of Open Access Journals (Sweden)

    A K Sharma

    1983-01-01

    Full Text Available One hundred patients with moderate to severe pyoderma were treated with oral oxytetracycline. The most common organism isolated were coagulase positive Staph pyogenes and Str betahemolyticus. Of 100 patients; 87 showed a successful therapeutic response. The predictive value of in vitro test for bacterial susceptibility to oxytetracycline (30 mcg disc was 88% for "sensitive" reports but 17% for "resistant" reports.Judged by clinical response the incidence of false sensitive reports was 12% (9/87 but that of false resistant reports was 83 (22/26.

  19. Effectiveness and Mechanisms of Antagonism of Toxic Effects of Cyanide by Alpha-Keto Acids.

    Science.gov (United States)

    1986-12-31

    until the miss-w near death. Lethal blood levels of cyanide in alpha-KG treated animl. as levels of 5-7 mcg cyani0e, which so 5-7 times the expected...lethal levels . rwm these studies, alpha-KC is effettive in antagonising administered dos of CH of five time the lethal dose before the toxic effects are...parameters in the dog .................. 26 Table 6 The effects of cyanide on 2,3 diphosphoglyceric acid .......... 28 Table 7 Stability of solution of ci

  20. [Clebopride in premedication in ambulatory interventions in general anesthesia].

    Science.gov (United States)

    Migliavacca, S; Speranza, R; Cipolla, M; Laveneziana, D

    1992-03-01

    The authors examine the antiemetic effects of 1 mg clebopride administered iv after surgery, vs a placebo, by making a double blind randomized study on two groups of 40 women comparable by age and weight. The 2 groups of outpatients, admitted for short gynecological surgery, underwent diagnostic uterine curettage. They were anaesthetized with a cocktail of 2.5 mcg/kg fentanyl and 0.25 mg/kg ketamine, on spontaneous respiration. Nausea, vomiting and the other side effects were evaluated 3-6 hours after surgery. Statistically, clebopride proved more effective than placebo against nausea and vomiting (P ranging between 0.05-0.01), with no relevant side effects.

  1. Chelating capacity and the adverse effects of two treatments (N-acetylcysteine and D-penicillamine in patients with mercury poisoning in Segovia, a municipality at the northeastern part of Antioquia, Colombia

    Directory of Open Access Journals (Sweden)

    Fanny Cuesta González

    2008-02-01

    Full Text Available

    OBJECTIVE: to compare the chelating capacity and the adverse effects of treatments with either Nacetylcysteine or D-penicillamine in patients with mercury poisoning in Segovia, a municipality at the northeastern part of Antioquia, Colombia.

    METHODS: 50 patients with toxic levels of mercury were enrolled in a 10 days open label, randomized comparison of either D-penicillamine (750 mg/day or Nacetilcysteine (1.8 g/day. Patients were followed on a daily basis to assess the elimination of mercury in urine and the frequency of adverse effects of each treatment.

    RESULTS: 32 patients completed 10 days of drug treatment. Averages of mercury elimination in 24 hours urine, before and after treatment with D-penicillamine and N-acetylcysteine, were not different (211.96 mcg ± 190 and 262.15 mcg ± 305 and 232.85 mcg ± 248 and 218.65 mcg ± 240, respectively, P > 0.05 for all comparisons. Evaluation of the frequency of adverse effects showed a significant difference between the two groups: D-penicillamine (50% and N-acetylcysteine (11% p = 0.0079.

    CONCLUSION: this study

  2. Severe acute myocardial infarction and peripheral thrombosis in patient with bladder cancer

    Directory of Open Access Journals (Sweden)

    Ahmet Seyfeddin Gürbüz

    2017-12-01

    Full Text Available Cancer-associated thrombosis worsens the lives of patients substantially. Venous manifestations of cancer-associated thrombosis include deep vein thrombosis and pulmonary embolism. Arterial events include stroke and myocardial infarction. In this patient, myocardial infarction and cardiogenic shock are associated with diffuse coronary thrombosis together with peripheral thrombosis. He had surgery because of bladder carcinoma. Severe hypercoagulable condition probably facilitated by cancer itself and surgery caused multivessel coronary and peripheral intense thrombus burden. Intracoronary 10 mcg/kg tirofiban bolus and 15 mg tissue plasminogen activator (tPA were administered respectively before revascularization and thrombectomy operation was performed. Complete revascularization was achieved.

  3. [Effect of indolylacetic acid on formation of bacteroid forms of Rhizobium leguminosarum].

    Science.gov (United States)

    Lobanok, E V; Bakanchikova, T I

    1979-01-01

    The purpose of this work was to study the effect of indolylacetic acid (IAA) on the strains of Rhizobium leguminosarum, effective and noneffective with respect to symbiotic nitrogen fixation (L4 and 245a, and 14--73, respectively). IAA at a concentration of 50 mcg/ml and higher inhibited the growth of the bacterium, temporarily delayed celular division, and induced intensive formation of elongated bacteroid-like cells, predominantly Y-shaped or having a clavate shape. Many bacteroid-like cells were capable of division after a certain delay.

  4. Gender does not influence the response to the combination of salmeterol and fluticasone propionate in COPD

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Soriano, Joan B; Anderson, Julie A

    2004-01-01

    The prevalence of chronic obstructive pulmonary disease (COPD) in women is increasing worldwide. Women may have greater susceptibility to COPD progression than men, and differences in efficacy and safety of respiratory medications by gender are largely unexplored. We aimed to determine whether...... the response to treatment in women with COPD differed from men in a large, 1-year double-blind trial ('TRISTAN'). In a sensitivity analysis, we compared 539 male and 180 female COPD patients, who were randomized to the saLmeterol/fluticasone combination 50/500mcg bid or placebo for 12 months. Combination...

  5. Caso: Infección cutánea en el punto de punción de anestesia subaracnoidea

    OpenAIRE

    López Pérez, Jesús; Castañer Ramón-Llín, Carla; Furones Tormo, Beatriz; Fernández Fernández, María Adoración; García Ferreira, Joaquín; Fayos de la Asunción, Miguel E

    2012-01-01

    Mujer de 76 años de edad, con antecedentes de asma bronquial en tratamiento con bromuro de ipatropio e hipertiroidismo tratado con carbimazol. Artrosis generalizada y gonartrosis bilateral. Propuesta para cirugía traumatológica de protesis total de rodilla derecha. Se realiza técnica locorregional mediante anestesia subaracnoidea resultando exitosa tras 4 intentos fallidos de punción, confirmando salida de LCR transparente. Se administra bupivacaina isobárica 14 mg. más 20 mcg de fentanilo...

  6. Iodine deficiency status of school going children in coastal region of bangladesh

    International Nuclear Information System (INIS)

    Sayedur Rahman Miah; Chowdhury Habibur Rasul; Ashoke Kumar Paul

    2004-01-01

    Objective: Bangladesh is an iodine deficient zone, affected mainly in the northern part i.e., in Himalayan belt along Brahmaputra and Jamuna River. Severity of' iodine deficiency can be assessed by prevalence of goitre and urinary iodine excretion. The latest nationwide survey of Iodine Deficiency Disorders of' Bangladesh in 1993 showed prevalence of goitre 47.1% in all age and sex group and 69% of the population had urinary iodine excretion 100 mcg/L. Conclusion: On the basis of goitre prevalence and urinary iodine excretion, coastal region of Bangladesh is a mild iodine deficient zone. (authors)

  7. NORMOTHERMIA FOR PEDIATRIC AND CONGENITAL HEART SURGERY: AN EXPANDED HORIZON

    Directory of Open Access Journals (Sweden)

    Ahmad Mahir eShamsuddin

    2015-04-01

    Full Text Available Cardiopulmonary bypass (CPB in pediatric cardiac surgery is generally performed with hypothermia, flow reduction and hemodilution. From 10/2013 to 12/2014 55 patients, median age 6 years (range 2 months to 52 years, median weight 18.5kg (range 3.2 to 57 kg, underwent surgery with normothermic high flow CPB in a new unit.There were no early or late deaths. Fifty patients (90.9% were extubated within 3 hrs, 3 (5.5% within 24 hrs and 2 (3.6% within 48 hrs. Twentyfour patients (43.6% didn’t require inotropic support, 31 (56.4% received dopamine or dobutamine: 21 ≤5 mcg/kg/min, 8 5-10 mcg/kg/min, and 2 >10 mcg/kg/min. Two patients (6.5% required noradrenaline 0.05-0.1 mcg/kg/min.On arrival to ICU and after 3 and 6 hrs and 8:00 am the next morning, mean lactate levels were 1.9±09, 2.0±1.2, 1.6±0.8 and 1.4±0.7 mmol/L (0.6-5.2 mmol/L respectively. From arrival to ICU to 8:00 am the next morning mean urine output was 3.8±1.5 mL/kg/hr (0.7-7.6 mL/kg/hr, and mean chest drainage was 0.6±0.5 mL/kg/hr (0.1-2.3 mL/kg/hr. Mean ICU and hospital stay were 2.7±1.4 days (2-8 days and 7.2±2.2 days (4-15 days respectively. In conclusion, normothermic high flow CPB allows pediatric and congenital heart surgery with favorable outcomes even in a new unit. The immediate post-operative period is characterized by low requirement for inotropic and respiratory support, low lactate production, adequate urine output, minimal drainage from the chest drains, shorter ICU and hospital stay.

  8. Elastic characteristics and microplastic deformation of amorphous alloys on iron base

    International Nuclear Information System (INIS)

    Pol'dyaeva, G.P.; Zakharov, E.K.; Ovcharov, V.P.; Tret'yakov, B.N.

    1983-01-01

    Investigation results of elasticity and microplasticity properties (modulus of normal elasticity E, elasticity limit σsub(0.01) and yield limit σsub(0.2)) of three amorphous alloys on iron base Fe 80 B 20 , Fe 70 Cr 10 B 20 and Fe 70 Cr 5 Ni 5 B 20 are given. Amorphous band of the alloys is obtained using the method of melt hardening. It is shown that amorphous alloys on iron base possess high elasticity and yield limits and hardness and are very perspective for the use as spring materials

  9. SwissProt search result: AK070850 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK070850 J023066B20 (Q14576) ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic... cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21) ELAV3_HUMAN 1e-17 ...

  10. 75 FR 9401 - Office of Safe and Drug-Free Schools; Overview Information; Grants To Reduce Alcohol Abuse...

    Science.gov (United States)

    2010-03-02

    ... Department's National Center for Education Statistics (NCES); and (b) 20 percent or more of the children ages 5 through 17 years served by the LEA are from families with incomes below the poverty line. The...

  11. An Assessment of Alternative Diesel Fuels: Microbiological Contamination and Corrosion Under Storage Conditions

    Science.gov (United States)

    2010-08-01

    and B20) In experiments with additions of distilled water, all fuels supported biofilm formation Changes in the water pH did not correlate with...ULSD) and blends of ULSD and B100 (B5 and B20). In experiments with additions of distilled water, all fuels supported biofilm formation . Changes in...corrosion; diesel; biodiesel; biofouling; MIC; carbon steel ; aluminum; stainless steel Introduction Microbial contamination of hydrocarbon fuels

  12. Alternative Fuels Data Center: Alaska Transportation Data for Alternative

    Science.gov (United States)

    fuels Fuel Public Private Biodiesel (B20 and above) 0 0 Compressed Natural Gas (CNG) 1 0 Electric 8 0 Coast Region National Average per unit sold per GGE per unit sold per GGE Biodiesel (B20) $3.01/gallon $2.74/GGE $2.84/gallon $2.58/GGE Biodiesel (B99-B100) $3.61/gallon $3.57/GGE $3.48/gallon $3.45/GGE

  13. A comparative study of clonidine versus a combination of diazepam and atropine for premedication in orthopaedic patients.

    Directory of Open Access Journals (Sweden)

    Chaurasia S

    1999-07-01

    Full Text Available Sixty patients in the age group of 18-60 years of A.S.A. Grade I/II risk, scheduled for elective orthopaedic surgeries under general anaesthesia were studied for pre-medication with either oral clonidine or with combination of effects of diazepam & atropine. Patients in Group A (clonidine group received tablet clonidine 100 mcg (1 tablet if less than 50 kg in weight and 200 mcg if weighing more than 50 kg two hours before surgery. Patients in Group B (Diazepam-atropine group received one tablet of Diazepam (10 mg orally two hours before surgery and injection atropine-sulphate 0.01 mg/kg half an hour preoperatively by intramuscular route. In our study, the sedative and anti-sialogogue effects of clonidine were comparable to those of diazepam-atropine combination, which are commonly used premedicants. The anti-anxiety effect of clonidine was found to be better than that of diazepam-atropine combination. Clonidine also proved to be a better agent for the attenuation of pressor response to laryngoscopy and intubation. Thus, oral clonidine is a better premedicant compared to atropine-diazepam combination. Also, it is a more acceptable agent because of its oral route of administration.

  14. Effects of Computer-Aided Manufacturing Technology on Precision of Clinical Metal-Free Restorations

    Directory of Open Access Journals (Sweden)

    Ki-Hong Lee

    2015-01-01

    Full Text Available Purpose. The purpose of this study was to investigate the marginal fit of metal-free crowns made by three different computer-aided design/computer-aided manufacturing (CAD/CAM systems. Materials and Methods. The maxillary left first premolar of a dentiform was prepared for all-ceramic crown restoration. Thirty all-ceramic premolar crowns were made, ten each manufactured by the Lava system, Cercon, and Cerec. Ten metal ceramic gold (MCG crowns served as control. The marginal gap of each sample was measured under a stereoscopic microscope at 75x magnification after cementation. One-way ANOVA and the Duncan’s post hoc test were used for data analysis at the significance level of 0.05. Results. The mean (standard deviation marginal gaps were 70.5 (34.4 μm for the MCG crowns, 87.2 (22.8 μm for Lava, 58.5 (17.6 μm for Cercon, and 72.3 (30.8 μm for Cerec. There were no significant differences in the marginal fit among the groups except that the Cercon crowns had significantly smaller marginal gaps than the Lava crowns (P<0.001.  Conclusions. Within the limitation of this study, all the metal-free restorations made by the digital CAD/CAM systems had clinically acceptable marginal accuracy.

  15. Low Dose Propofol-induced Amnesia Is Not Due to a Failure of Encoding: Left Inferior Prefrontal Cortex Is Still Active

    Science.gov (United States)

    Veselis, Robert A.; Pryor, Kane O.; Reinsel, Ruth A.; Mehta, Meghana; Pan, Hong; Johnson, Ray

    2008-01-01

    Background Propofol may produce amnesia by affecting encoding. The hypothesis that propofol weakens encoding was tested by measuring regional cerebral blood flow during verbal encoding. Methods 17 volunteer participants (12 M, 30.4±6.5 years old) had regional cerebral blood flow measured using H2O15 positron emission tomography during complex and simple encoding tasks (deep vs. shallow level of processing), to identify a region of interest in the left inferior prefrontal cortex (LIPFC). The effect of either propofol (n=6, 0.9 mcg/ml target concentration), placebo with a divided attention task (n=5), or thiopental at sedative doses (n=6, 3 mcg/ml) on regional cerebral blood flow activation in the LIPFC was tested. The divided attention task was expected to decrease activation in the LIPFC. Results Propofol did not impair encoding performance or reaction times, but impaired recognition memory of deeply encoded words 4 hours later (median recognition of 35% (17–54 interquartile) of words presented during propofol versus 65% (38–91) before drug, pdeep encoding was present in this region of interest in each group before drug (T>4.41, pprocesses. PMID:18648230

  16. Developing fetal motor-cardiovascular coordination analyzed from multi-channel magnetocardiography

    International Nuclear Information System (INIS)

    Schmidt, A; Witte, O W; Hoyer, D; Schneider, U; Schleußner, E

    2014-01-01

    Fetal movements (FM) related heart rate accelerations (AC) are an important maturation criterion. Since Doppler-based time resolution is not sufficient for accompanying heart rate variability analysis, the work is aimed at a comprehensive FM-AC analysis using magnetocardiographic recordings from fetuses during sleep. We identify FM and AC by independent component analysis and automatic recognition algorithms. We investigate associations between FM and AC of different magnitude by means of event coincidence and time series cross-correlation over the maturation period of 21–40 weeks of gestation (WGA). FM related AC appear with increasing AC magnitude and WGA. Vice versa, AC related FM appear independent of WGA, but more frequently with increasing AC amplitude. The FM-AC correlation exists already at 21 WGA and further increases with WGA while the variability of its time delay decreases. Hence, FM and AC are clearly associated over the whole investigated maturation period. The increase of FM related AC runs parallel to the increasing AC magnitude. The MCG methodology was confirmed and results from previous Doppler-based analyses reproduced. Hence, MCG recordings allow the collective analysis of heart rate variability based maturation indices and FM related AC. This synergism may improve the diagnosis of fetal developmental disorders. (paper)

  17. Advances in biomagnetic research using high- T{sub c} superconducting quantum interference devices

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Hong-Chang [Department of Physics/Institute of Applied Physics, National Taiwan University, Taipei 106, Taiwan (China); Horng, Herng-Er; Yang, S Y [Institute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Liao, Shu-Hsien, E-mail: hcyang@phys.ntu.edu.t [Department of Physics, National Taiwan Normal University, Taipei 116, Taiwan (China)

    2009-09-15

    This review reports the advances of biomagnetic research using high- T{sub c} superconducting quantum interference devices (SQUIDs). It especially focuses on SQUID-detected magnetocardiography (MCG), magnetically labeled immunoassays (MLIs) as well as nuclear magnetic resonance and imaging (NMR/MRI). The progress in MCG that scientists have made and the encountered challenges are discussed here. This study includes the early detection of the electromagnetic change in cardiac activity in animal studies of hypercholesterolemic rabbits, which suggests the possibility of early diagnosis of cardiac disease in clinical applications. The progress on MLIs using measurements of remanence, magnetic relaxation and magnetic susceptibility reduction is presented. The wash-free immunomagnetic reduction shows both high sensitivity and high specificity. NMR/MRI of high spectral resolution and of high signal-to-noise ratio are addressed and discussed. The proton-phosphate J-coupling of trimethyl phosphate ((CH{sub 3}){sub 3}PO{sub 4}) in one shot in microtesla fields is demonstrated. The prospects of biomagnetic applications are addressed. (topical review)

  18. The Vertical Distribution of Sediment Archaeal Community in the “Black Bloom” Disturbing Zhushan Bay of Lake Taihu

    Science.gov (United States)

    Fan, Xianfang; Xing, Peng

    2016-01-01

    Using the Illumina sequencing technology, we investigated the vertical distribution of archaeal community in the sediment of Zhushan Bay of Lake Taihu, where the black bloom frequently occurred in summer. Overall, the Miscellaneous Crenarchaeotal Group (MCG), Deep Sea Hydrothermal Vent Group 6 (DHVEG-6), and Methanobacterium dominated the archaeal community. However, we observed significant difference in composition of archaeal community among different depths of the sediment. DHVEG-6 dominated in the surface layer (0–3 cm) sediment. Methanobacterium was the dominating archaeal taxa in the L2 (3–6 cm) and L3 (6–10) sediment. MCG was most abundant in the L4 (10–15 cm) and L5 (15–20 cm) sediment. Besides, DHVEG-6 was significantly affected by the concentration of total phosphorus (TP). And loss on ignition (LOI) was an important environmental factor for Methanobacterium. As the typical archaeal taxa in the surface layer sediment, DHVEG-6 and Methanobacterium might be more adapted to abundant substrate supply from cyanobacterial blooms and take active part in the biomass transformation. We propose that DHVEG-6 and Methanobacterium could be the key archaeal taxa correlated with the “black bloom” formation in Zhushan Bay. PMID:26884723

  19. A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery

    Directory of Open Access Journals (Sweden)

    Ganapathi Mavuri

    2017-01-01

    Full Text Available Background: Alpha-2 adenoreceptors as an adjuvant to local anesthetic during caudal analgesia in children prolongs the duration of analgesia. This study was designed to compare the analgesic efficacy and adverse effects of dexmedetomidine and clonidine when added to ropivacaine for caudal analgesia in children undergoing lower abdominal surgeries. Methods: In a prospective study, Seventy-eight children received block with either 0.2% ropivacaine 1.5 mg/kg (Group R; n = 26 or 0.2% ropivacaine 1.5 mg/kg + 1 mcg/kg clonidine (Group RC; n = 26 or 0.2% ropivacaine 1.5 mg/kg + dexmedetomidine 1 mcg/kg (Group RD; n = 26. Results: Duration of analgesia was 7.15 ± 1.00 h in Group R, 11.57 ± 1.27 h in Group R + C, and 14.73 ± 1.53 h in Group R + D (P 0.05. Conclusion: Addition of clonidine and dexmedetomidine to caudal ropivacaine significantly prolongs the duration of analgesia without adverse effects.

  20. [Predictors of long-term remission after transsphenoidal surgery in Cushing's disease].

    Science.gov (United States)

    Abellán Galiana, Pablo; Fajardo Montañana, Carmen; Riesgo Suárez, Pedro Antonio; Gómez Vela, José; Escrivá, Carlos Meseguer; Lillo, Vicente Rovira

    2013-10-01

    There is no consensus on the remission criteria for Cushing's disease or on the definition of disease recurrence after transsphenoidal surgery, and comparison of the different published series is therefore difficult. A long-term recurrence rate of Cushing's disease ranging from 2%-25% has been reported. Predictors of long-term remission reported include: 1) adenoma-related factors (aggressiveness, size, preoperative identification in MRI), 2) surgery-related factors, mainly neurosurgeon experience, 3) clinical factors, of which dependence on and duration of glucocorticoid treatment are most important, and 4) biochemical factors. Among the latter, low postoperative cortisol levels, less than 2 mcg/dL predict for disease remission. However, even when undetectable plasma cortisol levels are present, long-term recurrence may still occur and lifetime follow-up is required. We report the preliminary results of the first 20 patients with Cushing's disease operated on at our hospital using nadir cortisol levels less than 2 mcg/dl as remission criterion. Copyright © 2012 SEEN. Published by Elsevier Espana. All rights reserved.

  1. Combination effect of low dose fentanyl and propofol on emergence agitation in children following sevoflurane anesthesia

    International Nuclear Information System (INIS)

    Bakhamees, Hassan S; Mercan, Arzu; ElHalafawy, Yasser M

    2009-01-01

    To investigate the combination effect of low dose fentanyl and subhypnotic dose of propofol on emergence agitation in children receiving sevoflurane for adenotonsillectomy procedure.After ethical approval, a prospective, randomized, clinical study was performed in Saad Specialist Hospital, Al-Khobar, Kingdom of Saudi Arabia in 2007-2008. One hundred and twenty children in physical status of I according to the American Society of Anesthesiologists, aged 2-6 years, scheduled for adentonsillectomy under general anesthesia were allocated into 3 groups randomly. Anesthesia was induced and maintained by sevoflurane in all groups. Children received 0.1 ml.kg-1 normal saline at the end of surgery in group C (n=40), 1.5 mcg.kg-1 fentanyl during induction, and 0.1 ml.kg-1 normal saline at the end of surgery in group F (n=40), and 1.5 mcg.kg-1 fentanyl during induction and 1 mg.kg-1 propofol at the end of surgery in group FP (n=40). Postoperative agitation was recorded, if any, for the first postoperative hour.Three groups were comparable with regard to demographic data. Twenty-one patients (53%) in the control group, 14 patients (35%) in group F and 7 (18%) patients in group FP experienced postoperative agitation.The combination of low dose fentanyl before surgery and propofol at the end of surgery decreases the incidence and level of emergence agitation in children after adenotonsillectomy procedure under sevoflurane anesthesia. (author)

  2. In vitro antimicrobial activity and antagonistic effect of essential oils from plant species.

    Science.gov (United States)

    Toroglu, Sevil

    2007-07-01

    Kahramanmaras, is a developing city located in the southern part of Turkey Thymus eigii (M. Zohary and RH. Davis) Jalas, Pinus nigraAm. sub sp pallasiana and Cupressus sempervirens L. are the useful plants of the Kahramanmaras province and have been understudy since 2004 for the traditional uses of plants empiric drug, spice, herbal tea industry herbal gum and fuel. The study was designed to examine the antimicrobial activities of essential oils of these plants by the disc diffusion and minimum inhibitory concentration (MIC) methods. In addition, antimicrobial activity of Thymus eigii was researched by effects when it was used together with antibiotics and even when it was combined with other essential oils. When the results of this study were compared with vancomycin (30 mcg) and erytromycin (15 mcg) standards, it was found that Thymus eigii essential oil was particularly found to possess strongerantimicrobial activity whereas other essential oils showed susceptible or moderate activity However, antimicrobial activity changed also by in vitro interactions between antibiotics and Thymus eigii essential oil, also between essential oils of these plants and that of Thymus eigii causing synergic, additive, antagonist effect.

  3. DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data.

    Science.gov (United States)

    Zhang, Yuanwei; Zang, Qiguang; Zhang, Huan; Ban, Rongjun; Yang, Yifan; Iqbal, Furhan; Li, Ao; Shi, Qinghua

    2016-07-08

    Small RNA (sRNA) Sequencing technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent variations from their canonical sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). However, integrated tool to precisely detect and systematically annotate isomiRs from sRNA sequencing data is still in great demand. Here, we present an online tool, DeAnnIso (Detection and Annotation of IsomiRs from sRNA sequencing data). DeAnnIso can detect all the isomiRs in an uploaded sample, and can extract the differentially expressing isomiRs from paired or multiple samples. Once the isomiRs detection is accomplished, detailed annotation information, including isomiRs expression, isomiRs classification, SNPs in miRNAs and tissue specific isomiR expression are provided to users. Furthermore, DeAnnIso provides a comprehensive module of target analysis and enrichment analysis for the selected isomiRs. Taken together, DeAnnIso is convenient for users to screen for isomiRs of their interest and useful for further functional studies. The server is implemented in PHP + Perl + R and available to all users for free at: http://mcg.ustc.edu.cn/bsc/deanniso/ and http://mcg2.ustc.edu.cn/bsc/deanniso/. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  4. [Subclinical and manifested hypothyroidism as a consequence of thyroid autoimmune disease].

    Science.gov (United States)

    Milosević, Dragoslav P; Djurica, Snezana; Davidović, Mladen; Stević, Radmila; Rajić, Miodrag; Marković, Natasa

    2005-10-01

    Chronic thyroiditis (Hashimoto's disease) is a slowly developing persistent inflamation of the thyroid gland, which frequently leads to hypothyroidism. Some of the up-to-date knowledge about hypothyroidism, both subclinical and manifested, caused by autoimmune disease, was presented. Autoimmune thyroid gland disease can occur at any age, but predominantly affects women after periods of high emotional and physical stress or accidents, as well as during periods of hormonal changes. It can also develop in families, and having an autoimmune disease slightly increases the risk of developing another. This paper showed an increasing incidence of subclinical hypothyroidism (4.17%) in elderly, and, at the same time, the incidence of primary hypothyroidism accounting for 1%. It is very usefull to estimate the stimulated thyrotropin (TSH) response, as well as the value of fast, short time thyroid gland reserves, analyzed by T3 and T4 serum level at 60th minute after TRH stimulation. Treatment of choice for HT (hypothyroidism of any cause) is thyroid hormone replacement. Drug of choice is orally administered levothyroxine sodium, usually for life-time. The standard dose is 1.6-1.8 mcg/kg body weight per day, but is in most cases patient dependent. Elderly patients usually require smaller replacement dose of levothyroxine, sometimes less than 1 mcg/kg body weight per day with coronary dilatator at the same time.

  5. Postoperative nausea and vomiting prophylaxis: A comparative study of ondansetron, granisetron and granisetron and dexamethasone combination after modified radical mastectomy

    Directory of Open Access Journals (Sweden)

    Pushplata Gupta

    2014-01-01

    Full Text Available Background: Post-operative nausea and vomiting (PONV is commonly seen after modified radical mastectomy (MRM. In this randomized double-blind prospective study we compared the efficacy of ondansetron, granisetron and granisetron and dexamethasone combination for prevention of PONV following MRM in female patients. Materials and Methods: A total of 75 patients (20-60 years of age undergoing elective MRM were randomly allocated to one of the three groups of 25 patients each. Group O received ondansetron 4 mg, Group G received granisetron 40 mcg/kg and group granisetron and dexamethasone (G + D received granisetron 40 mcg/kg + dexamethasone 8 mg prior to induction. All episodes of PONV within 24 h after induction of anesthesia were recorded. Statistical Analysis: Statistical analysis was done using Kruskal-Wallis test (nonparametric ANOVA. Results: The incidence of complete response (no PONV, no rescue medication was 96% with G+D, as compared with 86% with granisetron and 4% with ondansetron during 0-3h after surgery which was clinically significant (P < 0.05. Similarly clinically significant response was seen during 3-6, 6-9, 9-12 and 12-24 h of surgery. Conclusion: Granisetron and dexamethasone combination is more effective for prevention of PONV in comparison to individual ondansetron and granisetron in MRM.

  6. Sugammadex versus two doses of neostigmine for reversal of rocuronium in gastric sleeve surgery

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    Abdulhamid Alsaeed

    2017-01-01

    Patients and Methods: A total of 110 patients with body mass index> 40 underwent elective gastric sleeve surgery were enrolled in this study. Exclusion criteria included patients with co-existing muscular and cardiovascular diseases. Patients were randomly allocated to one of the following groups: group A (SUG, Group B (NEO 2.5 mg, and Group C (NEO 5 mg. General anesthesia was induced in the three groups using propofol 2.0 mg/kg of corrected body weight (CBW and fentanyl 3 mcg/kg of CBW. Anesthesia was maintained with O2/air/desflurane 1 minimum alveolar concentration. Remifentanil infusion started at 0.05–0.2 mcg/kg/min. Tracheal intubation was facilitated with rocuronium 1.2 mg/kg of CBW guided with PNS. When the train of four (TOF reached zero, intubation was performed using a GlideScope. At the end of surgery, TOF ratio and posttetanic counts were recorded. SUG 2 mg/kg of CBW (Group A, NEO 2.5 mg (Group B, and NEO 5 mg (Group C were administered according to the random envelope. The time to achieve 90% of TOF was recorded in seconds using a timer. ANOVA for repeated measurements was used for statistical analyses. P 90%, the recovery pattern of both was similar.

  7. Metabolic disposition of CI-924, a new lipid regulating agent, in laboratory animals

    International Nuclear Information System (INIS)

    Mertz, N.; Windsor, B.; Chang, T.

    1986-01-01

    The disposition of carbon-14 labeled CI-924 (I), 5,5'-[1,1-biphenyl]-2,5 diyl-bis(oxy)-bis-2,2'-dimethylpentanoic acid, was studied in beagle dogs and rats following single 10 mg/kg po doses. Serial plasma, urine and fecal samples were collected up to 168 hr and analyzed for total radioactivity. Peak 14 C plasma concentrations of 31 mcg/ml (dogs) and 66 mcg/ml (rats) were attained within 0.5 and 1.0 hr after dosing. The concentrations declined thereafter with estimated half life of 11 and 5 hr in rats and dogs, respectively. TLC radiochromatography revealed that I was the only component in circulating blood. Tissue distribution study in rats showed that the highest 14 C concentrations were found in plasma and liver with decreasing concentrations in lung, heart, kidney, skin, gonads, spleen, fat, muscle, adrenals, and brain. All tissue concentrations declined in parallel with plasma levels with half lives of 14-22 hr. Urinary and fecal excretion accounted for 1-3% and 92-96% of the dose, respectively. Balance study in bile duct cannulated rats showed that 90%, 1%, and 1% of the dose was excreted in bile, urine, and feces. Unchanged drug and varying amounts of its conjugate were the only products present in bile, urine or feces. These results indicate that I was completely absorbed and eliminated primarily by biliary excretion in the form of unchanged drug and its conjugate

  8. Effects of Computer-Aided Manufacturing Technology on Precision of Clinical Metal-Free Restorations.

    Science.gov (United States)

    Lee, Ki-Hong; Yeo, In-Sung; Wu, Benjamin M; Yang, Jae-Ho; Han, Jung-Suk; Kim, Sung-Hun; Yi, Yang-Jin; Kwon, Taek-Ka

    2015-01-01

    The purpose of this study was to investigate the marginal fit of metal-free crowns made by three different computer-aided design/computer-aided manufacturing (CAD/CAM) systems. The maxillary left first premolar of a dentiform was prepared for all-ceramic crown restoration. Thirty all-ceramic premolar crowns were made, ten each manufactured by the Lava system, Cercon, and Cerec. Ten metal ceramic gold (MCG) crowns served as control. The marginal gap of each sample was measured under a stereoscopic microscope at 75x magnification after cementation. One-way ANOVA and the Duncan's post hoc test were used for data analysis at the significance level of 0.05. The mean (standard deviation) marginal gaps were 70.5 (34.4) μm for the MCG crowns, 87.2 (22.8) μm for Lava, 58.5 (17.6) μm for Cercon, and 72.3 (30.8) μm for Cerec. There were no significant differences in the marginal fit among the groups except that the Cercon crowns had significantly smaller marginal gaps than the Lava crowns (P < 0.001). Within the limitation of this study, all the metal-free restorations made by the digital CAD/CAM systems had clinically acceptable marginal accuracy.

  9. β2-agonista de longa duração na doença pulmonar obstrutiva crônica (DPOC

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    CAMPOS LUIZ EDUARDO MENDES

    2000-01-01

    Full Text Available No paciente com DPOC, os β2-agonistas de longa duração são capazes de produzir broncodilatação de intensidade semelhante à dos anticolinérgicos, mas, devido a sua propriedade lipofílica, a ação se prolonga por um período até 12 horas após a sua administração. Estudos comparativos entre salmeterol e formoterol sugerem eqüipotência entre 50mcg de salmeterol e 24 ou 12mcg de formoterol quando este é administrado respectivamente através do aerossol dosimetrado ou turbuhaler. É preciso considerar o tipo de inalador para se estabelecer a eqüipotência entre os dois agentes. Até mesmo pacientes com DPOC e cardiopatia associada podem fazer uso dos β2-agonistas de longa duração com segurança. O salmeterol, por ser agonista parcial, é mais seguro nesses casos de maior risco. A terapia broncodilatadora escalonada na DPOC pode ser revista. Brometo de tiotrópio é um novo anticolinérgico cuja ação pode se prolongar por mais de 1-3 dias e talvez seja o novo broncodilatador mais promissor na DPOC

  10. Weekly Intramuscular Injection of Levothyroxine following Myxoedema: A Practical Solution to an Old Crisis

    Directory of Open Access Journals (Sweden)

    Peter N. Taylor

    2015-01-01

    Full Text Available An 82-year-old female with known hypothyroidism was admitted to hospital after being found on the floor. On examination, she was unkempt, confused, bradycardic, hypothermic, and barely arousable. Initial biochemistry revealed a thyroid stimulating hormone (TSH of >100 mU/L and free thyroxine (FT4 level of 1.5 pmol/L which supported a diagnosis of myxoedema coma. She was resuscitated and commenced on liothyronine, levothyroxine, and hydrocortisone and some improvement was made. It became apparent that she was hiding and spitting out her oral levothyroxine including levothyroxine elixir. Given the need for prompt alternative control, we sought advice from international experts where intramuscular levothyroxine was recommended. She was managed from day 50 onwards with intramuscular levothyroxine 200 mcg once a week, which was subsequently increased to 500 mcg. Thyroid function normalized and she made continual cognitive and physical progress and was discharged to a rehabilitation hospital. Her intramuscular levothyroxine was stopped and she was subsequently restarted on oral levothyroxine, with a plan for on-going close monitoring of her thyroid function. This report highlights the potential to use intramuscular levothyroxine in individuals with severe hypothyroidism arising from poor compliance with levothyroxine treatment or other potential causes such as impaired absorption.

  11. Mycelial compatibility and aggressiveness of Sclerotinia sclerotiorum isolates from Brazil and the United States

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    Lucimara Junko Koga

    2014-04-01

    Full Text Available The objective of this work was to evaluate the genetic diversity among Sclerotinia sclerotiorum isolates from Brazil and the USA, assess their aggressiveness variability, and verify the existence of an isolate-cultivar interaction. Isolate variability was determined by mycelial compatibility grouping (MCG, and isolate aggressiveness by cut-stem inoculations of soybean cultivars. Two experiments for MCGs and two for aggressiveness were conducted with two sets of isolates. The first set included nine isolates from the same soybean field in Brazil and nine from the Midwest region of the USA. The second set included 16 isolates from several regions of Brazil and one from the USA. In the first set, 18 isolates formed 12 different MCGs. In the second set, 81% of the isolates from Brazil grouped into a single MCG. No common MCGs were observed among isolates from Brazil and the USA. The isolates showed aggressiveness differences in the first set, but not in the second. Although aggressiveness differed in the first set, soybean cultivars and isolates did not interact significantly. Cultivar rank remained the same, regardless of the genetic diversity, aggressiveness difference, and region or country of origin of the isolate. Results from screening of soybean cultivars, performed by the cut-stem method in the USA, can be used as reference for researchers in Brazil.

  12. arXiv Improved Monte Carlo Glauber predictions at present and future nuclear colliders

    CERN Document Server

    Loizides, Constantin; d'Enterria, David

    2018-05-23

    We present the results of an improved Monte Carlo Glauber (MCG) model of relevance for collisions involving nuclei at center-of-mass energies of BNL RHIC ($\\sqrt{s_{\\rm NN}}=0.2$ TeV), CERN LHC ($\\sqrt{s_{\\rm NN}}=2.76$-$8.8$ TeV), and proposed future hadron colliders ($\\sqrt{s_{\\rm NN}}\\approx 10$-$63$ TeV). The inelastic pp cross sections as a function of $\\sqrt{s_{\\rm NN}}$ are obtained from a precise data-driven parametrization that exploits the many available measurements at LHC collision energies. We describe the nuclear transverse profile with two separated 2-parameter Fermi distributions for protons and neutrons to account for their different densities close to the nuclear periphery. Furthermore, we model the nucleon degrees of freedom inside the nucleus through a lattice with a minimum nodal separation, combined with a "recentering and reweighting" procedure, that overcomes some limitations of previous MCG approaches. The nuclear overlap function, number of participant nucleons and binary nucleon-nuc...

  13. Buyers beware: lead poisoning due to Ayurvedic medicine.

    Science.gov (United States)

    Pierce, J Matthew R; Estrada, Carlos A; Mathews, Ronnie E

    2012-10-01

    A 29-year-old man, who recently emigrated from India, presented with a 2-week history of abdominal pain, as well as nausea, constipation, and fatigue. He underwent removal of a parathyroid adenoma 6 weeks prior to admission and received a locally made Indian traditional medicine (Ayurveda) for pain control; however, this information was not initially available. He was instructed to take approximately 15 g/day. Initial evaluation revealed a normocytic anemia, but other workup including imaging and endoscopy was unrevealing. Given his recent use of Ayurvedic medicines, we tested for lead poisoning and found a blood lead level of 72 mcg/dl. We sent his medicine for analysis and found it had a high lead concentration of 36,000 mcg/g, which is over 25,000 times the maximum daily dose. He improved with cessation of the medicine and treatment with succimer. Lead poisoning can present with a variety of nonspecific signs and symptoms, including abdominal pain and anemia. Ayurvedic medicines, as well as traditional medicines from other cultures, may be a source of lead or other heavy metals. It is essential for physicians to be aware of adverse effects of Ayurvedic medicines as they are easily available and increasing in popularity.

  14. Analysis of Movement Acceleration of Down's Syndrome Teenagers Playing Computer Games.

    Science.gov (United States)

    Carrogi-Vianna, Daniela; Lopes, Paulo Batista; Cymrot, Raquel; Hengles Almeida, Jefferson Jesus; Yazaki, Marcos Lomonaco; Blascovi-Assis, Silvana Maria

    2017-12-01

    This study aimed to evaluate movement acceleration characteristics in adolescents with Down syndrome (DS) and typical development (TD), while playing bowling and golf videogames on the Nintendo ® Wii™. The sample comprised 21 adolescents diagnosed with DS and 33 with TD of both sexes, between 10 and 14 years of age. The arm swing accelerations of the dominant upper limb were collected as measures during the bowling and the golf games. The first valid measurement, verified by the software readings, recorded at the start of each of the games, was used in the analysis. In the bowling game, the groups presented significant statistical differences, with the maximum (M) peaks of acceleration for the Male Control Group (MCG) (M = 70.37) and Female Control Group (FCG) (M = 70.51) when compared with Male Down Syndrome Group (MDSG) (M = 45.33) and Female Down Syndrome Group (FDSG) (M = 37.24). In the golf game the groups also presented significant statistical differences, the only difference being that the maximum peaks of acceleration for both male groups were superior compared with the female groups, MCG (M = 74.80) and FCG (M = 56.80), as well as in MDSG (M = 45.12) and in FDSG (M = 30.52). It was possible to use accelerometry to evaluate the movement acceleration characteristics of teenagers diagnosed with DS during virtual bowling and golf games played on the Nintendo Wii console.

  15. Upper airway morphology in Down Syndrome patients under dexmedetomidine sedation

    Directory of Open Access Journals (Sweden)

    Rajeev Subramanyam

    Full Text Available Abstract Background and objectives: Children with Down Syndrome are vulnerable to significant upper airway obstruction due to relative macroglossia and dynamic airway collapse. The objective of this study was to compare the upper airway dimensions of children with Down Syndrome and obstructive sleep apnea with normal airway under dexmedetomidine sedation. Methods: IRB approval was obtained. In this retrospective study, clinically indicated dynamic sagittal midline magnetic resonance images of the upper airway were obtained under low (1 mcg/kg/h and high (3 mcg/kg/h dose dexmedetomidine. Airway anteroposterior diameters and sectional areas were measured as minimum and maximum dimensions by two independent observers at soft palate (nasopharyngeal airway and at base of the tongue (retroglossal airway. Results and conclusions: Minimum anteroposterior diameter and minimum sectional area at nasopharynx and retroglossal airway were significantly reduced in Down Syndrome compared to normal airway at both low and high dose dexmedetomidine. However, there were no significant differences between low and high dose dexmedetomidine in both Down Syndrome and normal airway. The mean apnea hypopnea index in Down Syndrome was 16 ± 11. Under dexmedetomidine sedation, children with Down Syndrome and obstructive sleep apnea when compared to normal airway children show significant reductions in airway dimensions most pronounced at the narrowest points in the nasopharyngeal and retroglossal airways.

  16. Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms

    Science.gov (United States)

    Markova, Natalyia; Chernopiatko, Anton; Schroeter, Careen A.; Malin, Dmitry; Kubatiev, Aslan; Bachurin, Sergey; Costa-Nunes, João; Steinbusch, Harry M. W.; Strekalova, Tatyana

    2013-01-01

    Central thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression. In contrast to 3,3′,5-triiodo-L-thyronine (T3), the role of 3,5-diiodo-L-thyronine (T2), which until recently was considered an inactive metabolite of T3, has not been studied in these pathologies. However, both T3 and T2 stimulate mitochondrial respiration, a factor counteracting the pathogenesis of depressive disorder, but the cellular origins in the CNS, mechanisms, and kinetics of the cellular action for these two hormones are distinct and independent of each other. Here, Illumina and RT PCR assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone regulation, is increased in resilience to stress-induced depressive syndrome and after antidepressant treatment in mice that might suggest elevated T2 and T3 turnover in these phenotypes. In a separate experiment, bolus administration of T2 at the doses 750 and 1500 mcg/kg but not 250 mcg/kg in naive mice reduced immobility in a two-day tail suspension test in various settings without changing locomotion or anxiety. This demonstrates an antidepressant-like effect of T2 that could be exploited clinically. In a wider context, the current study suggests important central functions of T2, whose biological role only lately is becoming to be elucidated. PMID:24386638

  17. Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms

    Directory of Open Access Journals (Sweden)

    Natalyia Markova

    2013-01-01

    Full Text Available Central thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression. In contrast to 3,3′,5-triiodo-L-thyronine (T3, the role of 3,5-diiodo-L-thyronine (T2, which until recently was considered an inactive metabolite of T3, has not been studied in these pathologies. However, both T3 and T2 stimulate mitochondrial respiration, a factor counteracting the pathogenesis of depressive disorder, but the cellular origins in the CNS, mechanisms, and kinetics of the cellular action for these two hormones are distinct and independent of each other. Here, Illumina and RT PCR assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone regulation, is increased in resilience to stress-induced depressive syndrome and after antidepressant treatment in mice that might suggest elevated T2 and T3 turnover in these phenotypes. In a separate experiment, bolus administration of T2 at the doses 750 and 1500 mcg/kg but not 250 mcg/kg in naive mice reduced immobility in a two-day tail suspension test in various settings without changing locomotion or anxiety. This demonstrates an antidepressant-like effect of T2 that could be exploited clinically. In a wider context, the current study suggests important central functions of T2, whose biological role only lately is becoming to be elucidated.

  18. Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    Valéria G. F. Pinheiro

    Full Text Available Low antimycobacterial drug concentrations have been observed in tuberculosis (TB patients under treatment. The lactulose/mannitol urinary excretion test (L/M, normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R and isoniazid (H were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for R (8-24 mcg/mL or H (3-6 mcg/mL in 16/18 patients. Analyzing the drugs individually, 12/18 patients had low serum concentrations of R, 13/18 for H and 8/18 for both drugs. We suggest that there is a decrease in the functional absorptive area of the intestine in TB patients, which would explain the reduced serum concentrations of antituberculosis drugs. There is a need for new approaches to improve drug bioavailability in TB patients.

  19. Applications of the Schilling test and saturation analysis techniques to the investigation of absorption and transport of vitamin B-12 in Ugandans. Part of a coordinated programme on in vitro assay techniques

    International Nuclear Information System (INIS)

    Kajubi, S.K.; Okel, R.M.

    1975-11-01

    The absorption of Vitamin B12 in 21 subjects was investigated, using the Schilling test. One microgramme of radioactive Vitamin B12 followed by a flushing dose of 1000 mcg after 2 hours resulted in very low urinary excrection rates. Different flushing doses were administered to 11 asymptomatic volunteers at different times after the active dose. Adequate excretion was obtained when a flushing dose of 5000 mcg of B12 was given five hours after the active dose. In 23 other subjects this combination was found to give excretion rates comparable to those found in other populations where the usual procedure had been used. Plasma and urine patterns of radioactivity showed that, when the standard method was used, there was no failure of vitamin absorption but flushing from the plasma was poor. Flushing was more effective with the modified procedure. An additional binder in the plasma of Ugandans is likely; its effect may have combined with the previously demonstrated slow rate of absorption of vitamin to make the modified method effective and the standard one ineffective. A new procedure for the Schilling test is therefore proposed for this population since the standard method would be unsuitable

  20. Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder.

    Science.gov (United States)

    Moon, Chung-Man; Yang, Jong-Chul; Jeong, Gwang-Woo

    2015-11-01

    Generalized anxiety disorder (GAD) is associated with brain function and morphological alterations. This study investigated explicit verbal memory impairment in patients with GAD in terms of brain functional deficits in combination with morphologic changes. Seventeen patients with GAD and 17 healthy controls matched for age, sex, and education level underwent high-resolution T1-weighted MRI and fMR imaging at 3 T during explicit verbal memory tasks with emotionally neutral and anxiety-inducing words. In response to the neutral words, the patients showed significantly lower activities in the regions of the hippocampus (Hip), middle cingulate gyrus (MCG), putamen (Pu) and head of the caudate nucleus (HCd) compared with healthy controls. In response to the anxiety-inducing words, the patients showed significantly higher activities in the ventrolateral prefrontal cortex and precentral gyrus. However, they showed lower activities in the Hip, MCG, Pu and HCd. In addition, patients with GAD showed a significant reduction in gray matter volumes, especially in the regions of the Hip, midbrain, thalamus, insula and superior temporal gyrus, compared with healthy controls. This study examined a small sample sizes in each of the groups, and there was no consideration of a medication effect on brain activity and volume changes. This study provides evidence for the association between brain functional deficits and morphometric alterations in an explicit verbal memory task for patients with GAD. This finding is helpful for understanding explicit verbal memory impairment in connection with GAD symptoms. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Presence of Antibiotic Resistant Enterococci in Rinses of Milking Equipment after Sanitation Process

    Directory of Open Access Journals (Sweden)

    Miroslav Kročko

    2011-10-01

    Full Text Available Enterococci are common milk contaminants, and microbial contamination of milk by this group of microorganisms can occur from a variety of sources. Significance of enterococci can be assessed by many separated points of view, otherwise a lot of research has focused on the potential role of food enterococci as reservoirs and/or vehicles of antibiotic resistance. The aim of this investigation was to evaluate the occurence of enterococci in rinses of milking equipment (n = 38 on two farms using automatic sanitation system. Our results showed, that alkaline disinfectant (on chlorine basis was effective towards enterococci because apart from 2 samples, their presence in rinses has not been determined. Average number of enterococci survived the aplication of acid disinfectant reached the value 5.00.101 CFU.ml-1. Together, 60 strains were randomly isolated and identified from the grown colonies of genus Enterococcus, and E. faecalis was the predominat species (69.6 %. In rinses, also E. faecium, E. mundtii and undefined enterococci were found. Among antibiotic resistant isolates, 83.9 % of isolates were sensitive to erytromycin (15mcg/disk and resistant to vancomycin (30 mcg/disk were 20 % of isolates.

  2. Radiotherapy combined with Tegafur (FT-207s) for brain tumors

    International Nuclear Information System (INIS)

    Aoki, Yoshiro

    1981-01-01

    5-Fluorouracil (5-FU) has anti-tumor effects as an anti-metabolite, but it cannot pass the Blood-Brain-Barrier (BBB). FT-207 a masked-compound of 5-FU, is easily lipid soluble and is able to pass the BBB. Twenty eight patients of primary brain tumor and 8 patients of metastatic brain tumor were treated with irradiation combined with 750 mg of FT-207 suppository. Twenty four patients of primary brain tumor were treated only with irradiation as control. The mean survival time was 20.4 +- 11.8 months for the combined therapy group and 17.6 +- 8.6 months for the control. The concentration of FT-207 and 5-FU in serum and in cerebrospinal fluid (CSF) was investigated after administration of 750 mg of FT-207 suppository per annum. The maximum concentration of FT-207 and of 5-FU in serum was 20.4 +- 11.8 mcg/ml and 0.06 +- 0.02 mcg/ml, respectively. There were observed several side effects, such as anorexia, nausea, exanthema and etc. These side effects were not so great as to interrupt the therapy at the dose level of 750 mg of FT-207. However, at the dose of 1500 mg, one case showed disturbance of consciousness, to which attention should be called. (author)

  3. Premature Coronary Artery Disease due to Homozygous Familial Hypercholesterolemia in a 12-Year-Old Girl

    Directory of Open Access Journals (Sweden)

    Filiz Ekici

    2018-03-01

    Full Text Available Background: Homozygous familial hypercholesterolemia is a rare inherited metabolic disease caused by low-density lipoprotein receptor abnormality. Patients with homozygous familial hypercholesterolemia have an increased risk of cardiovascular complication that usually occurs in the first decade of life. Here, we report a 12-year-old girl with an unpredicted presentation for coronary artery disease and found to have homozygous familial hypercholesterolemia. Case Report: A 12-year-old girl was admitted to our unit with syncope. Chest X-ray showed bilateral diffuse pneumonic consolidation and mild cardiomegaly. We detected stable ST depression by electrocardiography. Echocardiography showed normal systolic functions. Troponin-1 levels were high (66 mcg/dL, upper limit: 0.04 mcg/dL. Influenza A virus DNA was detected by the respiratory viral panel. After her successful treatment for acute pneumonia and myocarditis due to Influenza A virus, her syncope attacks persisted. Marked ST elevation was observed during exercise electrocardiography. Coronary angiography showed severe occlusions in the coronary arteries. High serum levels of total cholesterol (756 mg/dL and low-density lipoprotein-C (556 mg/dL were noticed. She had no tendon xanthomas. Medical histories revealed that her family members were diagnosed with heterozygous familial hypercholesterolemia. A coronary bypass surgery was performed. Statin and ezetimibe treatments were started. We also planned lipid apheresis. Conclusion: Children with homozygous familial hypercholesterolemia may present with symptoms of premature coronary heart disease requiring a routine lipid test and careful anamnesis.

  4. Diversity and Distribution of Archaea Community along a Stratigraphic Permafrost Profile from Qinghai-Tibetan Plateau, China

    Directory of Open Access Journals (Sweden)

    Shiping Wei

    2014-01-01

    Full Text Available Accompanying the thawing permafrost expected to result from the climate change, microbial decomposition of the massive amounts of frozen organic carbon stored in permafrost is a potential emission source of greenhouse gases, possibly leading to positive feedbacks to the greenhouse effect. In this study, the community composition of archaea in stratigraphic soils from an alpine permafrost of Qinghai-Tibetan Plateau was investigated. Phylogenic analysis of 16S rRNA sequences revealed that the community was predominantly constituted by Crenarchaeota and Euryarchaeota. The active layer contained a proportion of Crenarchaeota at 51.2%, with the proportion of Euryarchaeota at 48.8%, whereas the permafrost contained 41.2% Crenarchaeota and 58.8% Euryarchaeota, based on 16S rRNA gene sequence analysis. OTU1 and OTU11, affiliated to Group 1.3b/MCG-A within Crenarchaeota and the unclassified group within Euryarchaeota, respectively, were widely distributed in all sediment layers. However, OTU5 affiliated to Group 1.3b/MCG-A was primarily distributed in the active layers. Sequence analysis of the DGGE bands from the 16S rRNAs of methanogenic archaea showed that the majority of methanogens belonged to Methanosarcinales and Methanomicrobiales affiliated to Euryarchaeota and the uncultured ZC-I cluster affiliated to Methanosarcinales distributed in all the depths along the permafrost profile, which indicated a dominant group of methanogens occurring in the cold ecosystems.

  5. Neuroprotective Effect of Total and Sequential Extract of Scrophularia striata Boiss. in Rat Cerebellar Granule Neurons Following Glutamate- Induced Neurotoxicity: An In-vitro Study

    Science.gov (United States)

    Salavati, Parvin; Ramezani, Mina; Monsef-Esfahani, Hamid R; Hajiagha, Reza; Parsa, Maliheh; Tavajohi, Shoreh; Ostad, Seyed Nasser

    2013-01-01

    Neuroprotective effect of the extract from aerial parts of Scrophularia striata Boiss (Scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pups Cerebellar Granule Neurons (CGNs). CGNs from 8 days old Sprague-Dawley rat were prepared and cultured. The experiments were performed after 8 days in culture. The plant was collected from the northeastern part (Ruin region) of Iran and air-dried at room temperature. The total extract was prepared with maceration of prepared powder in ethanol 80% for three times. Sequential extracts were obtained using dried and powdered aerial parts with increasingly polar solvents: petroleum ether, chloroform, ethyl acetate and methanol 80% solution. Cultured cells were exposed to 125 μM of glutamate for 12 h following a 24 h of incubation with test fractions at concentration of 10 mcg/mL. Morphological assay was performed using invert light microscope after fixation and staining with haematoxylin. Neuronal viability was measured using MTT assay. Statistical analysis was done using SPSS software. One way analysis of variance (ANOVA) was performed by Tukey post-hoc test. Values were considered statistically significant when p-value ≤ 0.05. Results of this study showed a significant neuroprotective activity of high polarity methanolic fraction of aerial parts of Scrophularia striata against glutamate-induced neurotoxicity in a dosedependent manner. Treatment with 10 mcg/mL of the fractions showed the best result. PMID:24250613

  6. Toxicants in folk remedies: Implications of elevated blood lead in an American-born infant due to imported diaper powder

    Science.gov (United States)

    Karwowski, Mateusz P.; Morman, Suzette A.; Plumlee, Geoffrey S.; Law, Terence; Kellogg, Mark; Woolf, Alan D.

    2016-01-01

    Though most childhood lead exposure in the USA results from ingestion of lead-based paint dust, non-paint sources are increasingly implicated. We present interdisciplinary findings from and policy implications of a case of elevated blood lead (13–18 mcg/dL, reference level Malaysian folk diaper powder. Analyses showed the powder contains 62 % lead by weight (primarily lead oxide) and elevated antimony [1000 parts per million (ppm)], arsenic (55 ppm), bismuth (110 ppm), and thallium (31 ppm). These metals are highly bioaccessible in simulated gastric fluids, but only slightly bioaccessible in simulated lung fluids and simulated urine, suggesting that the primary lead exposure routes were ingestion via hand-mouth transmission and ingestion of inhaled dusts cleared from the respiratory tract. Four weeks after discontinuing use of the powder, the infant’s venous blood lead level was 8 mcg/dL. Unregulated, imported folk remedies can be a source of toxicant exposure. Additional research on import policy, product regulation, public health surveillance, and culturally sensitive risk communication is needed to develop efficacious risk reduction strategies in the USA. The more widespread use of contaminated folk remedies in the countries from which they originate is a substantial concern.

  7. Home blood sodium monitoring, sliding-scale fluid prescription and subcutaneous DDAVP for infantile diabetes insipidus with impaired thirst mechanism

    Directory of Open Access Journals (Sweden)

    Hameed Shihab

    2012-06-01

    Full Text Available Abstract Background/Aims Infants with diabetes insipidus (DI, especially those with impaired thirst mechanism or hypothalamic hyperphagia, are prone to severe sodium fluctuations, often requiring hospitalization. We aimed to avoid dangerous fluctuations in serum sodium and improve parental independence. Methods A 16-month old girl with central DI, absent thirst mechanism and hyperphagia following surgery for hypothalamic astrocytoma had erratic absorption of oral DDAVP during chemotherapy cycles. She required prolonged hospitalizations for hypernatremia and hyponatremic seizure. Intensive monitoring of fluid balance, weight and clinical assessment of hydration were not helpful in predicting serum sodium. Discharge home was deemed unsafe. Oral DDAVP was switched to subcutaneous (twice-daily injections, starting with 0.01mcg/dose, increasing to 0.024mcg/dose. The parents adjusted daily fluid allocation by sliding-scale, according to the blood sodium level (measured by handheld i-STAT analyser, Abbott. We adjusted the DDAVP dose if fluid allocation differed from maintenance requirements for 3 consecutive days. Results After 2.5 months, sodium was better controlled, with 84% of levels within reference range (135-145 mmol/L vs. only 51% on the old regimen (p = 0.0001. The sodium ranged from 132-154 mmol/L, compared to 120–156 on the old regimen. She was discharged home. Conclusion This practical regimen improved sodium control, parental independence, and allowed discharge home.

  8. Home blood sodium monitoring, sliding-scale fluid prescription and subcutaneous DDAVP for infantile diabetes insipidus with impaired thirst mechanism.

    Science.gov (United States)

    Hameed, Shihab; Mendoza-Cruz, Abel C; Neville, Kristen A; Woodhead, Helen J; Walker, Jan L; Verge, Charles F

    2012-06-09

    Infants with diabetes insipidus (DI), especially those with impaired thirst mechanism or hypothalamic hyperphagia, are prone to severe sodium fluctuations, often requiring hospitalization. We aimed to avoid dangerous fluctuations in serum sodium and improve parental independence. A 16-month old girl with central DI, absent thirst mechanism and hyperphagia following surgery for hypothalamic astrocytoma had erratic absorption of oral DDAVP during chemotherapy cycles. She required prolonged hospitalizations for hypernatremia and hyponatremic seizure. Intensive monitoring of fluid balance, weight and clinical assessment of hydration were not helpful in predicting serum sodium. Discharge home was deemed unsafe. Oral DDAVP was switched to subcutaneous (twice-daily injections, starting with 0.01mcg/dose, increasing to 0.024mcg/dose). The parents adjusted daily fluid allocation by sliding-scale, according to the blood sodium level (measured by handheld i-STAT analyser, Abbott). We adjusted the DDAVP dose if fluid allocation differed from maintenance requirements for 3 consecutive days. After 2.5 months, sodium was better controlled, with 84% of levels within reference range (135-145 mmol/L) vs. only 51% on the old regimen (p = 0.0001). The sodium ranged from 132-154 mmol/L, compared to 120-156 on the old regimen. She was discharged home. This practical regimen improved sodium control, parental independence, and allowed discharge home.

  9. Environmental lead exposure is associated with visit-to-visit systolic blood pressure variability in the US adults.

    Science.gov (United States)

    Faramawi, Mohammed F; Delongchamp, Robert; Lin, Yu-Sheng; Liu, Youcheng; Abouelenien, Saly; Fischbach, Lori; Jadhav, Supriya

    2015-04-01

    The association between environmental lead exposure and blood pressure variability, an important risk factor for cardiovascular disease, is unexplored and unknown. The objective of the study was to test the hypothesis that lead exposure is associated with blood pressure variability. American participants 17 years of age or older from National Health and Nutrition Examination Survey III were included in the analysis. Participants' blood lead concentrations expressed as micrograms per deciliter were determined. The standard deviations of visit-to-visit systolic and diastolic blood pressure were calculated to determine blood pressure variability. Multivariable regression analyses adjusted for age, gender, race, smoking and socioeconomic status were employed. The participants' mean age and mean blood lead concentration were 42.72 years and 3.44 mcg/dl, respectively. Systolic blood pressure variability was significantly associated with environmental lead exposure after adjusting for the effect of the confounders. The unadjusted and adjusted means of visit-to-visit systolic blood pressure variability and the β coefficient of lead exposure were 3.44, 3.33 mcg/dl, β coefficient = 0.07, P variability. Screening adults with fluctuating blood pressure for lead exposure could be warranted.

  10. A mobile test facility based on a magnetic cumulative generator to study the stability of the power plants under impact of lightning currents

    Energy Technology Data Exchange (ETDEWEB)

    Shurupov, A. V.; Zavalova, V. E., E-mail: zavalova@fites.ru; Kozlov, A. V.; Shurupov, M. A. [Russian Academy of Sciences, Joint Institute for High Temperatures (Russian Federation)

    2016-12-15

    The report presents the results of the development and field testing of a mobile test facility based on a helical magnetic cumulative generator (MCGTF). The system is designed for full-scale modeling of lightning currents to study the safety of power plants of any type, including nuclear power plants. Advanced technologies of high-energy physics for solving both engineering and applied problems underlie this pilot project. The energy from the magnetic cumulative generator (MCG) is transferred to a high-impedance load with high efficiency of more than 50% using pulse transformer coupling. Modeling of the dynamics of the MEG that operates in a circuit with lumped parameters allows one to apply the law of inductance output during operation of the MCG, thus providing the required front of the current pulse in the load without using any switches. The results of field testing of the MCGTF are presented for both the ground loop and the model load. The ground loop generates a load resistance of 2–4 Ω. In the tests, the ohmic resistance of the model load is 10 Ω. It is shown that the current pulse parameters recorded in the resistive-inductive load are close to the calculated values.

  11. Electroencephalographic Changes Associated with Antinociceptive Actions of Lidocaine, Ketamine, Meloxicam, and Morphine Administration in Minimally Anaesthetized Dogs

    Directory of Open Access Journals (Sweden)

    Ubedullah Kaka

    2015-01-01

    Full Text Available Effects of ketamine and lidocaine on electroencephalographic (EEG changes were evaluated in minimally anaesthetized dogs, subjected to electric stimulus. Six dogs were subjected to six treatments in a crossover design with a washout period of one week. Dogs were subjected to intravenous boluses of lidocaine 2 mg/kg, ketamine 3 mg/kg, meloxicam 0.2 mg/kg, morphine 0.2 mg/kg and loading doses of lidocaine 2 mg/kg followed by continuous rate infusion (CRI of 50 and 100 mcg/kg/min, and ketamine 3 mg/kg followed by CRI of 10 and 50 mcg/kg/min. Electroencephalogram was recorded during electrical stimulation prior to any drug treatment (before treatment and during electrical stimulation following treatment with the drugs (after treatment under anaesthesia. Anaesthesia was induced with propofol and maintained with halothane at a stable concentration between 0.85 and 0.95%. Pretreatment median frequency was evidently increased (P<0.05 for all treatment groups. Lidocaine, ketamine, and morphine depressed the median frequency resulting from the posttreatment stimulation. The depression of median frequency suggested evident antinociceptive effects of these treatments in dogs. It is therefore concluded that lidocaine and ketamine can be used in the analgesic protocol for the postoperative pain management in dogs.

  12. Psychosexual well-being in women using oral contraceptives containing drospirenone.

    Science.gov (United States)

    Nappi, Rossella E; Albani, Francesca; Tonani, Silvia; Santamaria, Valentina; Pisani, Carla; Terreno, Erica; Martini, Ellis; Polatti, Franco

    2009-01-01

    Considerable advances have been made in hormonal contraception in recent years, geared at maximizing compliance and minimizing discontinuation. In oral contraceptive (OC) formulations, the estrogenic component, generally ethinyl estradiol (EE), has been reduced significantly and newer progestins like dienogest and drospirenone (DRSP), compounds with different molecular structures, have been introduced; in addition, new regimens (extended, flexible, 24/4 formats instead of the standard 21/7 format) and innovative delivery systems (vaginal rings, transdermal patches, subcutaneous implants and intrauterine devices) are available. The multitude of choices allows hormonal contraception to be tailored to the individual woman in order to obtain non-contraceptive benefits, without significant side effects, and also a favorable risk/benefit profile for her general and reproductive health. Over the past few years, new OC formulations combining DRSP (3 mg), a unique progestin with both antimineralocorticoid and antiandrogenic activities, with estrogen (30 mcg or 20 mcg EE), in two regimens (24/4 and 21/7) of active pills in a 28-day cycle, have shown positive effects on water retention-related weight gain and physical, emotional and psychosexual well-being. It seems likely that the use of a low-dose, well-balanced OC and the shorter 4-day hormone-free interval may minimize the side effects that can impair quality of life and thus increase women's compliance with hormonal contraception therapy.

  13. Chronic obstructive pulmonary disease symptom effects of long-term cumulative exposure to ambient levels of total suspended particulates and sulfur dioxide in California Seventh-Day Adventist residents

    Energy Technology Data Exchange (ETDEWEB)

    Euler, G.L.; Abbey, D.E.; Magie, A.R.; Hodgkin, J.E.

    1987-07-01

    Risk of chronic obstructive pulmonary disease symptoms due to long-term exposure to ambient levels of total suspended particulates (TSP) and sulfur dioxide (SO/sub 2/) symptoms was ascertained using the National Heart, Lung, and Blood Institute (NHLBI) respiratory symptoms questionnaire on 7445 Seventh-Day Adventists. They were non-smokers, at least 25 yr of age, and had lived 11 yr or more in areas ranging from high to low photochemical air pollution in California. Participant cumulative exposures to each pollutant in excess of four thresholds were estimated using monthly residence zip code histories and interpolated dosages from state air monitoring stations. These pollutant thresholds were entered individually and in combination in multiple logistic regression analyses with eight covariables including passive smoking. Statistically significant associations with chronic symptoms were seen for: SO/sub 2/ exposure above 4 pphm (104 mcg/m3), (p = .03), relative risk 1.18 for 500 hr/yr of exposure; and for total suspended particulates (TSP) above 200 mcg/m3, (p less than .00001), relative risk of 1.22 for 750 hr/yr.

  14. Post Splenectomy Outcome in β-Thalassemia.

    Science.gov (United States)

    Merchant, Rashid H; Shah, Ami R; Ahmad, Javed; Karnik, Alka; Rai, Nooralam

    2015-12-01

    To evaluate changes in annual blood transfusion requirements and complications after splenectomy in patients with β-thalassemia. Forty post-splenectomy β-thalassemic patients aged 8-33 y, receiving regular blood transfusions and chelation therapy were included and non transfusion dependant patients were excluded from this retrospective cross-sectional study. Details about their surgery, transfusion requirements, and platelet levels were recorded on a standard proforma. All patients underwent a B-mode and color-coded duplex sonography of the hepatoportal system during the study period. The average ferritin level in the year prior to the study was 4432 mcg/L (range 480-12,200 mcg/L). The annual blood transfusion requirement in the first year and 5 y post splenectomy [mean ± SD (138.41 ± 90.38 ml/kg/y); (116 ± 41.44 ml/kg/y)] were significantly different from requirements before splenectomy [(mean ± SD) 294.85 ± 226 ml/kg/y; p value splenectomy with a mean rise of 4,51,000/mm(3) (p value splenectomy. Increase in annual blood transfusion requirement should be investigated to find the cause.

  15. Upper airway morphology in Down Syndrome patients under dexmedetomidine sedation.

    Science.gov (United States)

    Subramanyam, Rajeev; Fleck, Robert; McAuliffe, John; Radhakrishnan, Rupa; Jung, Dorothy; Patino, Mario; Mahmoud, Mohamed

    2016-01-01

    Children with Down Syndrome are vulnerable to significant upper airway obstruction due to relative macroglossia and dynamic airway collapse. The objective of this study was to compare the upper airway dimensions of children with Down Syndrome and obstructive sleep apnea with normal airway under dexmedetomidine sedation. IRB approval was obtained. In this retrospective study, clinically indicated dynamic sagittal midline magnetic resonance images of the upper airway were obtained under low (1mcg/kg/h) and high (3mcg/kg/h) dose dexmedetomidine. Airway anteroposterior diameters and sectional areas were measured as minimum and maximum dimensions by two independent observers at soft palate (nasopharyngeal airway) and at base of the tongue (retroglossal airway). Minimum anteroposterior diameter and minimum sectional area at nasopharynx and retroglossal airway were significantly reduced in Down Syndrome compared to normal airway at both low and high dose dexmedetomidine. However, there were no significant differences between low and high dose dexmedetomidine in both Down Syndrome and normal airway. The mean apnea hypopnea index in Down Syndrome was 16±11. Under dexmedetomidine sedation, children with Down Syndrome and obstructive sleep apnea when compared to normal airway children show significant reductions in airway dimensions most pronounced at the narrowest points in the nasopharyngeal and retroglossal airways. Copyright © 2015 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

  16. [Upper airway morphology in Down Syndrome patients under dexmedetomidine sedation].

    Science.gov (United States)

    Subramanyam, Rajeev; Fleck, Robert; McAuliffe, John; Radhakrishnan, Rupa; Jung, Dorothy; Patino, Mario; Mahmoud, Mohamed

    2016-01-01

    Children with Down Syndrome are vulnerable to significant upper airway obstruction due to relative macroglossia and dynamic airway collapse. The objective of this study was to compare the upper airway dimensions of children with Down Syndrome and obstructive sleep apnea with normal airway under dexmedetomidine sedation. IRB approval was obtained. In this retrospective study, clinically indicated dynamic sagittal midline magnetic resonance images of the upper airway were obtained under low (1mcg/kg/h) and high (3mcg/kg/h) dose dexmedetomidine. Airway anteroposterior diameters and sectional areas were measured as minimum and maximum dimensions by two independent observers at soft palate (nasopharyngeal airway) and at base of the tongue (retroglossal airway). Minimum anteroposterior diameter and minimum sectional area at nasopharynx and retroglossal airway were significantly reduced in Down Syndrome compared to normal airway at both low and high dose dexmedetomidine. However, there were no significant differences between low and high dose dexmedetomidine in both Down Syndrome and normal airway. The mean apnea hypopnea index in Down Syndrome was 16±11. Under dexmedetomidine sedation, children with Down Syndrome and obstructive sleep apnea when compared to normal airway children show significant reductions in airway dimensions most pronounced at the narrowest points in the nasopharyngeal and retroglossal airways. Copyright © 2015 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

  17. Anti-inflammatory effects of propofol during cardiopulmonary bypass: A pilot study

    Directory of Open Access Journals (Sweden)

    A Samir

    2015-01-01

    Full Text Available Introduction: Propofol has been suggested as a useful adjunct to cardiopulmonary bypass (CPB because of its potential protective effect on the heart mediated by a decrease in ischemia-reperfusion injury and inflammation at clinically relevant concentrations. In view of these potentially protective properties, which modulate many of the deleterious mechanism of inflammation attributable to reperfusion injury and CPB, we sought to determine whether starting a low dose of propofol infusion at the beginning of CPB would decrease inflammation as measured by pro-inflammatory markers. Materials and Methods: We enrolled 24 patients undergoing elective coronary artery bypass graft (CABG. The study group received propofol at rate of 120 mcg/kg/min immediately after starting CPB and was maintained throughout the surgery and for the following 6 hours in the intensive care unit (ICU. The control group received propofol dose of 30-50 mcg/kg/min which was started at the time of chest closure with wires and continued for the next 6 hours in the ICU. Interleukins (IL -6, -8 and -10 and tumor necrosis factor alpha (TNFalpha were assayed. Result: The most significant difference was in the level of IL-6 which had a P value of less than 0.06. Starting a low dose propofol early during the CPB was not associated with significant hemodynamic instability in comparison with the control group. Conclusion: Our study shows that propofol may be suitable as an anti-inflammatory adjunct for patients undergoing CABG.

  18. Acromegaly presenting as hirsuitism: Uncommon sinister aetiology of a common clinical sign

    Directory of Open Access Journals (Sweden)

    Rajesh Jain

    2012-01-01

    Full Text Available Hirsuitism though not uncommon (24%, is not considered to be a prominent feature of acromegaly because of its lack of specificity and occurrence. Hirsuitism is very common in women of reproductive age (5-7% and has been classically associated with polycystic ovarian syndrome (PCOS. Twenty-eight year lady with 3 year duration of hirsuitism (Modified Ferriman Gallwey score-24/36 , features of insulin resistance (acanthosis, subtle features of acromegaloidism (woody nose and bulbous lips was diagnosed to have acromegaly in view of elevated IGF-1 (1344 ng/ml; normal: 116-358 ng/ml, basal (45.1 ng/ml and post glucose growth hormone (39.94 ng/ml and MRI brain showing pituitary macroadenoma. Very high serum androstenedione (>10 ng/ml; normal 0.5-3.5 ng/ml, elevated testosterone (0.91 ng/ml, normal <0.8 and normal dehydroepiandrosterone sulphate (DHEAS (284 mcg/dl, normal 35-430 mcg/dl along with polycystic ovaries on ultrasonography lead to diagnosis of associated PCOS. She was also diagnosed to have diabetes. This case presentation intends to highlight that hirsuitism may rarely be the only prominent feature of acromegaly. A lookout for subtle features of acromegaly in all patients with hirsuitism and going for biochemical evaluation (even at the risk of investigating many patients of insulin resistance and acromegloidism may help us pick up more patients of acromegaly at an earlier stage thus help in reducing disease morbidity.

  19. Comparison of dural puncture epidural technique versus conventional epidural technique for labor analgesia in primigravida

    Directory of Open Access Journals (Sweden)

    Pritam Yadav

    2018-01-01

    Full Text Available >Background: Dural puncture epidural (DPE is a method in which a dural hole is created prior to epidural injection. This study was planned to evaluate whether dural puncture improves onset and duration of labor analgesia when compared to conventional epidural technique.Methods and Materials: Sixty term primigravida parturients of ASA grade I and II were randomly assigned to two groups of 30 each (Group E for conventional epidural and Group DE for dural puncture epidural. In group E, epidural space was identified and 18-gauge multi-orifice catheter was threaded 5 cm into the epidural space. In group DE, dura was punctured using the combines spinal epidural (CSE spinal needle and epidural catheter threaded as in group E followed by 10 ml of injection of Ropivacaine (0.2% with 20 mcg of Fentanyl (2 mcg/ml in fractions of 2.5 ml. Later, Ropivacaine 10 ml was given as a top-up on patient request. Onset, visual analouge scale (VAS, sensory and motor block, haemodynamic variables, duration of analgesia of initial dose were noted along with mode of delivery and the neonatal outcome.Results: Six parturients in group DE achieved adequate analgesia in 5 minutes while none of those in group E (P 0.05.Conclusions: Both techniques of labor analgesia are efficacious; dural puncture epidural has the potential to fasten onset and improve quality of labor analgesia when compared with conventional epidural technique.

  20. Experimental Investigation of Performance and emission characteristics of Various Nano Particles with Bio-Diesel blend on Di Diesel Engine

    Science.gov (United States)

    Karthik, N.; Goldwin Xavier, X.; Rajasekar, R.; Ganesh Bairavan, P.; Dhanseelan, S.

    2017-05-01

    Present study provides the effect of Zinc Oxide (ZnO) and Cerium Oxide (CeO2) nanoparticles additives on the Performance and emission uniqueness of Jatropha. Jatropha blended fuel is prepared by the emulsification technique with assist of mechanical agitator. Nano particles (Zinc Oxide (ZnO)) and Cerium Oxide (CeO2)) mixed with Jatropha blended fuel in mass fraction (100 ppm) with assist of an ultrasonicator. Experiments were conducted in single cylinder constant speed direct injection diesel engine for various test fuels. Performance results revealed that Brake Thermal Efficiency (BTE) of Jatropha blended Cerium Oxide (B20CE) is 3% and 11% higher than Jatropha blended zinc oxide (B20ZO) and Jatropha blended fuel (B20) and 4% lower than diesel fuel (D100) at full load conditions. Emission result shows that HC and CO emissions of Jatropha blended Cerium Oxide (B20CE) are (6%, 22%, 11% and 6%, 15%, 12%) less compared with Jatropha blended Zinc Oxide (B20ZO), diesel (D100) and Jatropha blended fuel (B20) at full load conditions. NOx emissions of Jatropha blended Cerium Oxide is 1 % higher than diesel fuel (D100) and 2% and 5% lower than Jatropha blended Zinc Oxide, and jatropha blended fuel.

  1. GROWTH PERFORMANCE AND CARCASS COMPOSITION OF RABBITS FED ON DIETS OF GRADUAL LEVELS OF BARLEY GRAIN

    Directory of Open Access Journals (Sweden)

    M.M. El-Adawy

    2012-05-01

    Full Text Available Forty-eight male New Zealand White rabbits of 6 weeks age (BW 875 ± 28.3 g were randomly allocated among six groups in different levels of barley grains (BG; 0 (B0, 5 (B5, 10 (B10, 15 (B15, 20 (B20, 25% (B25 of the total diet on growth performance and carcass composition of rabbits . The highest live BW value (P < 0.05 was obtained in B20 rabbits, whereas the highest feed intake (P < 0.05 value was obtained in B25 rabbits followed by those fed on the other diets. The better-feed conversion ratio (FCR was obtained in B20 rabbits followed by those of B15 and B25. Animals of B20 had better FCR than those of the other experimental diets. The relative contribution of soft feces to dry matter or crude protein intake differed (P < 0.05 among the experimental diets. The caecal turnover rate was increased (P < 0.05 in B15 and B20 rabbits than those other diets. The per-slaughter weight, hot and cold carcass weight and dressing percentage were differed (P < 0.05 among the experimental groups and highest values were recorded in B20 rabbits. Data suggested that a partial replacement of corn grains (CG by 20% BG in rabbit diets was increased live body weight, feed intake and feed conversion ratio.

  2. INFLUENCIA DEL TRATAMIENTO CON AMINAS EN LOS PARAMETROS HEMODINAMICOS y METABOLICOS EN EL SHOCK SEPTICO EXPERIMENTAL

    Directory of Open Access Journals (Sweden)

    Felisa Alonso Garcia,

    2003-01-01

    Full Text Available OBJETIVO: Estudiar las variaciones hemodinámicas y metabólicas de las primeras fases del Shock Séptico Experimental (SSE, inducidas por el tratamiento con distinta asociación de aminas. METODO: Investigación experimental en 22 perros. Se les indujo SSE mediante la administración de endotoxina de E. Coli (Serotipo 0111 B.M. Difco Laboratories. Michigan. USA. En función del tiempo se establecieron 5 fases: Basal ó "t=0" (considerado tiempo 0, SSE ó "t=30" (a los 30 minutos del inicio de la infusión del estímulo séptico, "t = 60", "t = 90" y "t = 120" a los 60, 90 y 120 minutos respectivamente de la administración de la endotoxina. En relación al tratamiento administrado, se distinguieron 3 grupos: Grupo A (n=7: tratamiento de soporte; Grupo B (n=8: Dopamina a 10 mcg/kg/min y Dobutamina a 5 mcg/kg/min (DPDB en la fase "t=60", DPDB más Noradrenalina (NA a 0,5 mcg/kg/min (NA0,5 en la fase "t=90"; DPDB más NA a 1 mcg/kg/min (NA1 en la fase "t=120"; Grupo C (n=7: Dopexamina a 12 mcg/kg/min (DX en la fase "t=60", DX más NA0,5 en la fase "t=90" y DX más NA1 en la fase "t=120". La comparación estadística se realizó mediante: "t" de Student-Fisher, Análisis de la Varianza, Chi Cuadrado y cálculo de la potencia estadística en caso necesario. RESULTADOS: Grupo B respecto al A: DP-DB NA0.5 aumentó la Frecuencia cardiaca (FC; DPDB-NA1 además incrementó la Presión diastólica (TAD. Grupo C respecto al A: DX- NA0,5 aumentó la FC; DX- NA1, incrementó la FC y TAD. CONCLUSIONES: La FC, TAS y TAD, se modificaron significativamente con las diversas asociaciones de aminas, mientras que no se evidenciaron variaciones intergrupo de la glucemia y plaquetas. Los cambios significativos en las últimas fases de la investigación experimental, de la glucemia y de las plaquetas, fueron secundarios a la progresión del shock séptico experimental y no a la diferente terapia recibida en cada grupo (ya que se comportaron de forma independiente al

  3. Analysis of Streptococcus bovis infections at a monographic oncological centre

    Directory of Open Access Journals (Sweden)

    Lozano TG

    2014-02-01

    interpretation of the results by the standards of the CLSI (Clinical and Laboratory Standards Institute, M100- S18. The results were: 14 strains (100% were sensitive to ampicillin (≤0.25 mcg / mL, amoxicillin-clavulanate (≤4/2 mg / mL, penicillin G (≤0.12 mcg / mL, cefotaxime (≤1 µg / mL, teicoplanin (≤8 mcg / mL, vancomycin (≤1 µg / mL and nitrofurantoin (≤32 mg / mL, 5 strains (35.71% were resistant to clindamycin (≥1 µg / mL, 6 (42.85% erythromycin (≥8 g / mL, 4 (28.57%, gentamicin (≥16 mg / mL, 3 (21.42%, tobramycin (≥16 mg / mL , 6 (42.85% to levofloxacin (≥8 mcg / mL, 8 (57.14% to ciprofloxacin (≥4 mg / mL, 9 (64.28% to tetracycline (≥8 mcg / mL and 6 (42.58% to trimethoprim-sulfamethoxazole (≥8/152 ug / mL.Regarding to the pathogenicity, there are reports on the degree of colonization of S. bovis (S. gallolyticus subsp. gallolyticus and colon cancer [1] ref code. It postulates several mechanisms involved in its pathogeny [2] ref code and it known the adhesion potential and invasion of endothelial cells or the ability to form biofilms [3] ref code, but if it is true, the relationship between colonization and oncogenesis is not entirely well defined.After analysing the isolated tumour epidemiology of our findings, no one of them was obtained from faecal samples or has been part of some study or active search for this microorganism.

  4. Effects of biodiesel on emissions of regulated air pollutants and polycyclic aromatic hydrocarbons under engine durability testing

    International Nuclear Information System (INIS)

    Hsi-Hsien Yang; Shu-Mei Chien; Mei-Yu Lo; John Chi-Wei Lan; Wen-Chang Lu; Yong-Yuan Ku

    2007-01-01

    An 80,000-km durability test was performed on two engines using diesel and biodiesel (methyl ester of waste cooking oil) as fuel in order to examine emissions resulting from the use of biodiesel. The test biodiesel (B20) was blended with 80% diesel and 20% methyl ester derived from waste cooking oil. Emissions of regulated air pollutants, including CO, HC, NO x , particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) were measured at 20,000-km intervals. The identical-model engines were installed on a standard dynamometer equipped with a dilution tunnel used to measure the pollutants. To simulate real-world driving conditions, emission measurements were made in accordance with the United States Environmental Protection Agency (USEPA) FTP transient cycle guidelines. At 0 km of the durability test, HC, CO and PM emission levels were lower for the B20 engine than those for diesel. After running for 20,000 km and longer, they were higher. However, the deterioration coefficients for these regulated air pollutants were not statistically higher than 1.0, implying that the emission factors do not increase significantly after 80,000 km of driving. Total (gaseous+particulate phase) PAH emission levels for both B20 and diesel decreased as the driving mileage accumulated. However, for the engine using B20 fuel, particulate PAH emissions increased as engine mileage increased. The average total PAH emission factors were 1097 and 1437 μg bhp h -1 for B20 and diesel, respectively. For B20, the benzo[a]pyrene equivalence emission factors were 0.77, 0.24, 0.20, 7.48, 5.43 and 14.1 μg bhp h -1 for 2-, 3-, 4-, 5-, 6-ringed and total PAHs. Results show that B20 use can reduce both PAH emission and its corresponding carcinogenic potency. (author)

  5. Experimental study of spray characteristics of biodiesel derived from waste cooking oil

    International Nuclear Information System (INIS)

    Mohan, Balaji; Yang, Wenming; Tay, Kun Lin; Yu, Wenbin

    2014-01-01

    Highlights: • B20 and diesel exhibit similar spray tip penetration and angle. • Change in orientation of spray shapes observed with different fuels. • B100 shows poor air fuel mixing compared to B20 and diesel. • Diesel shows higher equivalence ratio compared to B20 and B100. - Abstract: In this study, the fuel spray characteristics and air-fuel mixing process of waste cooking oil biodiesel (B100) and its blend with diesel (B20) were investigated and compared with diesel fuel. Spray characteristics such as spray tip penetration, spray angle, spray velocity and spray morphology were investigated under high injection and ambient pressure conditions using a constant volume spray chamber. The air-fuel mixing process was analysed using empirical relations like fuel volume, mass of air entrained within the spray and equivalence ratio. The results shows that B100 has higher spray tip penetration and velocity but narrow spray angles due to high viscosity and large momentum possessed by B100 compared to B20 and diesel fuels. The deviation in spray tip penetration reduces under high ambient pressure. The spray angle shows no change under various injection pressures; however it increases significantly under high ambient pressure. The spray shape is affected by the cavitation inside the injector nozzle holes. The fuel volume and amount of air entrainment within the spray showed that B100 exhibits poor air-fuel mixing compared to B20 and diesel fuels. Nevertheless, the equivalence ratio along the axial direction of spray reveals that the B100 has lean equivalence ratio compared to B20 and diesel fuel due to the presence of inherent oxygen content in its structure. A numerical simulation was conducted using new hybrid spray model implemented in KIVA4 and found that the results obtained from the simulation were in good agreement with the empirical results calculated from the experiments

  6. Effects of biodiesel on emissions of regulated air pollutants and polycyclic aromatic hydrocarbons under engine durability testing

    Energy Technology Data Exchange (ETDEWEB)

    Hsi-Hsien Yang; Shu-Mei Chien; Mei-Yu Lo [Chaoyang University of Technology, Wufong (China). Dept. of Environmental Engineering and Management; John Chi-Wei Lan [Yuan Ze University (China). Dept. of Chemical Engineering and Materials Science; Wen-Chang Lu [Industrial Technology Research Institute, Hsinchu (China). New Energy Div.; Yong-Yuan Ku [Automotive Research and Testing Center, Chunhwa (China). Diesel Vehicle Section

    2007-11-15

    An 80,000-km durability test was performed on two engines using diesel and biodiesel (methyl ester of waste cooking oil) as fuel in order to examine emissions resulting from the use of biodiesel. The test biodiesel (B20) was blended with 80% diesel and 20% methyl ester derived from waste cooking oil. Emissions of regulated air pollutants, including CO, HC, NO{sub x}, particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) were measured at 20,000-km intervals. The identical-model engines were installed on a standard dynamometer equipped with a dilution tunnel used to measure the pollutants. To simulate real-world driving conditions, emission measurements were made in accordance with the United States Environmental Protection Agency (USEPA) FTP transient cycle guidelines. At 0 km of the durability test, HC, CO and PM emission levels were lower for the B20 engine than those for diesel. After running for 20,000 km and longer, they were higher. However, the deterioration coefficients for these regulated air pollutants were not statistically higher than 1.0, implying that the emission factors do not increase significantly after 80,000 km of driving. Total (gaseous+particulate phase) PAH emission levels for both B20 and diesel decreased as the driving mileage accumulated. However, for the engine using B20 fuel, particulate PAH emissions increased as engine mileage increased. The average total PAH emission factors were 1097 and 1437 {mu}g bhp h{sup -1} for B20 and diesel, respectively. For B20, the benzo[a]pyrene equivalence emission factors were 0.77, 0.24, 0.20, 7.48, 5.43 and 14.1 {mu}g bhp h{sup -1} for 2-, 3-, 4-, 5-, 6-ringed and total PAHs. Results show that B20 use can reduce both PAH emission and its corresponding carcinogenic potency. (author)

  7. Tolerância a agente curarizante provocada pela administração repetida da droga Tolerance to curarizing drug induced by chronic administration: an experimental study

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Zanini

    1974-03-01

    Full Text Available Baseados em teoria discutível segundo a qual a miastenia grave é provocada pela presença no sangue de substância curarizante liberada pelo timo, tentou-se reproduzir um modelo experimental. Foram utilizados 40 ratos, criados nas mesmas condições, nascidos no mesmo dia, pesando ao redor de 350 g e divididos em 4 grupos: o Grupo I não foi manuseado; no Grupo II foi injetada solução fisiológica, 1 ml i.p. durante 6 semanas; no Grupo III foi injetada a dimetil tubocurarina (DMT 2,8 mcg/kg i.p., durante o mesmo tempo; no Grupo IV 14 mcg/kg da mesma droga foram injetados i.p. Uma semana após a última injeção i.p. os ratos, anestesiados, foram preparados para registro neuromuscular. O nervo ciático foi estimulado nas freqüências de 0,33 pulsos/seg, 70 pulsos/seg (séries de 10 pulsos a intervalos de 3 seg, 70 pulsos/seg (mantidos por 15 seg e novamente 0,33 pulsos/seg logo após a tetanização. A dose curarizante de DMT foi determinada por uma "terceira parte cega" quando 80% do bloqueio era alcançado. Quando apenas 10 estímulos em alta freqüência foram aplicados ao nervo, foi observada diferença significativa (pThe trial is a temptative experimental model of myasthenia gravis based on a doubtful theory whereby this disease is atributed to circulating curare in blood. Forty rats kept under the same conditions, bom on the same day and weighing around 350 g entered the trial, divided in four groups. Group I was not handled, Group II was injected with saline, 1 ml i.p. Group III was submitted to dimethyl tubocurarine iodide (DMT 2,8 mcg/kg i.p. and Group IV received 14 mcg/kg, all solutions being administered daily for a six-week period. One week after the last rats were anesthetized and prepared for cyatic-gastrocnemius neuro-muscular recording. Monopolar pulses were given at frequencies of 0.33 p/sec, 70 p/sec, (trains of 10 pulses at 3 sec intervals, 70 p/sec (kept for 15 sec and again 0.33 p/sec right after tetanus. Curarizing

  8. XMM FOLLOW-UP OBSERVATIONS OF THREE SWIFT BAT-SELECTED ACTIVE GALACTIC NUCLEI

    International Nuclear Information System (INIS)

    Trippe, M. L.; Reynolds, C. S.; Koss, M.; Mushotzky, R. F.; Winter, L. M.

    2011-01-01

    We present XMM-Newton observations of three active galactic nuclei (AGNs) taken as part of a hunt to find very heavily obscured Compton-thick AGNs. For obscuring columns greater than 10 25 cm -2 , AGNs are only visible at energies below 10 keV via reflected/scattered radiation, characterized by a flat power law. We therefore selected three objects (ESO 417-G006, IRAS 05218-1212, and MCG -01-05-047) from the Swift Burst Alert Telescope (BAT) hard X-ray survey catalog with Swift X-ray Telescope (XRT) 0.5-10 keV spectra with flat power-law indices as candidate Compton-thick sources for follow-up observations with the more sensitive instruments on XMM-Newton. The XMM spectra, however, rule out reflection-dominated models based on the weakness of the observed Fe Kα lines. Instead, the spectra are well fit by a model of a power-law continuum obscured by a Compton-thin absorber plus a soft excess. This result is consistent with previous follow-up observations of two other flat-spectrum BAT-detected AGNs. Thus, out of the six AGNs in the 22 month BAT catalog with apparently flat Swift XRT spectra, all five that have had follow-up observations are not likely Compton thick. We also present new optical spectra of two of these objects, IRAS 05218-1212 and MCG -01-05-047. Interestingly, though both the AGNs have similar X-ray spectra, their optical spectra are completely different, adding evidence against the simplest form of the geometric unified model of AGNs. IRAS 05218-1212 appears in the optical as a Seyfert 1, despite the ∼8.5 x 10 22 cm -2 line-of-sight absorbing column indicated by its X-ray spectrum. MCG -01-05-047's optical spectrum shows no sign of AGN activity; it appears as a normal galaxy.

  9. A randomized, double blind comparison of pethidine and ketoprofen as adjuvants for lignocaine in intravenous regional anaesthesia

    Directory of Open Access Journals (Sweden)

    Sameer N. Desai

    2014-07-01

    Full Text Available BACKGROUND AND OBJECTIVES: A review of all the adjuncts for intravenous regional anaesthesia concluded that there is good evidence to recommend NonSteroidal Anti-Inflammatory agents and pethidine in the dose of 30 mg dose as adjuncts to intravenous regional anaesthesia. But there are no studies to compare pethidine of 30 mg dose to any of the NonSteroidal Anti-Inflammatory agents. METHODS: In a prospective, randomized, double blind study, 45 patients were given intravenous regional anaesthesia with either lignocaine alone or lignocaine with pethidine 30 mg or lignocaine with ketprofen 100 mg. Fentanyl was used as rescue analgesic during surgery. For the first 6 h of postoperative period analgesia was provided by fentanyl injection and between 6 and 24 h analgesia was provided by diclofenac tablets. Visual analogue scores for pain and consumption of fentanyl and diclofenac were compared. RESULTS: The block was inadequate for one case each in lignocaine group and pethidine group, so general anaesthesia was provided. Time for the first dose of fentanyl required for postoperative analgesia was significantly more in pethidine and ketoprofen groups compared to lignocaine group (156.7 ± 148.8 and 153.0 ± 106.0 vs. 52.1 ± 52.4 min respectively. Total fentanyl consumption in first 6 h of postoperative period was less in pethidine and ketoprofen groups compared to lignocaine group (37.5 ± 29.0 mcg, 38.3 ± 20.8 mcg vs. 64.2 ± 27.2 mcg respectively. Consumption of diclofenac tablets was 2.4 ± 0.7, 2.5 ± 0.5 and 2.0 ± 0.7 in the control, pethidine and ketoprofen group respectively, which was statistically not significant. Side effects were not significantly different between the groups. CONCLUSION: Both pethidine and ketoprofen are equally effective in providing postoperative analgesia up to 6 h, without significant difference in the side effects and none of the adjuncts provide significant analgesia after 6 h.

  10. Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury

    Directory of Open Access Journals (Sweden)

    Nick Jeffery

    2018-02-01

    Full Text Available Background Glyburide (also known as glibenclamide is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important differences between spinal cord injury in experimental animals and in human clinical cases, making it difficult to introduce new therapies into clinical practice. Spinal cord injury is also common in pet dogs and requires new effective therapies, meaning that they can act as a translational model for the human condition while also deriving direct benefits from such research. In this study we investigated the pharmacokinetics and safety of glyburide in dogs with clinical spinal cord injury. Methods We recruited dogs that had incurred an acute thoracolumbar spinal cord injury within the previous 72 h. These had become acutely non-ambulatory on the pelvic limbs and were admitted to our veterinary hospitals to undergo anesthesia, cross sectional diagnostic imaging, and surgical decompression. Oral glyburide was given to each dog at a dose of 75 mcg/kg. In five dogs, we measured blood glucose concentrations for 10 h after a single oral dose. In six dogs, we measured serum glyburide and glucose concentrations for 24 h and estimated pharmacokinetic parameters to estimate a suitable dose for use in a subsequent clinical trial in similarly affected dogs. Results No detrimental effects of glyburide administration were detected in any participating dog. Peak serum concentrations of glyburide were attained at a mean of 13 h after dosing, and mean apparent elimination half-life was approximately 7 h. Observed mean maximum plasma concentration was 31 ng/mL. At the glyburide dose administered there was no observable association between glyburide and glucose concentrations in blood. Discussion Our data suggest that glyburide can be safely administered to dogs that are undergoing anesthesia, imaging and

  11. Antifertility effect of betal leaf stalk (Tambul patrabrint): a preliminary experimental study.

    Science.gov (United States)

    Tewari, P V; Chaturvedi, C; Dixit, S N

    1970-01-01

    This study was undertaken to determine possible antifertility properties of the stalk of the betel plant, Piper betle, which is extensively cultivated in warm moist parts of India for its leaves. The thin stalks were dried, powdered, and extracted with alcohol; the residue was used in the study and named betel leaf stalk extract (BLSE). It was macerated with gum acacia, suspended in distilled water, and diluted to 25 mg/ml. The drug was fed by oral intubation. Initially 20 rats were used in 2 groups, one receiving BLSE 50 mg/kg body weight for 10 days and the other vehicle only. Both were caged with males for 15 days. Only 2 of 10 rats receiving BLSE gave birth to litters while 9 of 10 controls delivered. Number of pups was also reduced. In another experiment using 60 female rats to 30 while BLSE at 50 mg/100 gm body weight was fed for 3 days during diestrus to 30 while 30 controls received vehicle only. Successful mating was confirmed by sperm in vaginal smears. 8 of 30 treated rats delivered 3.5 pups each while 29 of 30 controls delivered 7 pups per rat. In a third experiment 10 female rats were given BLSE 50mg/100 gm body weight, 10 vehicle only, and 10 neoclinesterol 150 mcg/100 gm body weight for 4 consecutive days. On Day 5 the animals were sacrificed and weights of uterus and ovaries recorded. Antiestrogenic properties were studied in oophorectomized rats given stilbestrol 150 mcg/100 gm body weight by injection, then fed 150 mcg/100 gm body weight of neoclinesterol or BLSE, 50 mg/100 gm, but the neoclinesterol. Vaginal smears were examined for cornification on Days 2, 3, and 4. Progestational activity was studied in 12 immature female rabbits injected with stilbestrol then treated with BLSE or leutocycline. Tests for estrogenic and antiestrogenic activity of BLSE were negative. A mild progestational activity was found in immature estrogen-primed rabbits but some follicle depressant type action was noted as several graffian follicles were seen in their

  12. Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum

    Science.gov (United States)

    Abdel-Azeem, Ahmed M.; Zaki, Sherif M.; Khalil, Waleed F.; Makhlouf, Noha A.; Farghaly, Lamiaa M.

    2016-01-01

    The aim of the present study was to investigate the anti-rheumatoid activity of secondary metabolites produced by endophytic mycobiota in Egypt. A total of 27 endophytic fungi were isolated from 10 dominant medicinal plant host species in Wadi Tala, Saint Katherine Protectorate, arid Sinai, Egypt. Of those taxa, seven isolates of Chaetomium globosum (CG1–CG7), being the most frequent taxon, were recovered from seven different host plants and screened for production of active anti-inflammatory metabolites. Isolates were cultivated on half – strength potato dextrose broth for 21 days at 28°C on a rotatory shaker at 180 rpm, and extracted in ethyl acetate and methanol, respectively. The probable inhibitory effects of both extracts against an adjuvant induced arthritis (AIA) rat model were examined and compared with the effects of methotrexate (MTX) as a standard disease-modifying anti-rheumatoid drug. Disease activity and mobility scoring of AIA, histopathology and transmission electron microscopy (TEM) were used to evaluate probable inhibitory roles. A significant reduction (P < 0.05) in the severity of arthritis was observed in both the methanolic extract of CG6 (MCG6) and MTX treatment groups 6 days after treatment commenced. The average arthritis score of the MCG6 treatment group was (10.7 ± 0.82) compared to (13.8 ± 0.98) in the positive control group. The mobility score of the MCG6 treatment group (1.50 ± 0.55) was significantly lower than that of the positive control group (3.33 ± 0.82). In contrast, the ethyl acetate extract of CG6 (EACG6) treatment group showed no improvements in arthritis and mobility scores in AIA model rats. Histopathology and TEM findings confirmed the observation. Isolate CG6 was subjected to sequencing for confirmation of phenotypic identification. The internal transcribed spacer (ITS) 1–5.8 s – ITS2 rDNA sequences obtained were compared with those deposited in the GenBank Database and registered with accession number KC

  13. A New Enzyme-Linked Immunosorbent Assay for a Total Anti-T Lymphocyte Globulin Determination: Development, Analytical Validation, and Clinical Applications.

    Science.gov (United States)

    Montagna, Michela; La Nasa, Giorgio; Bernardo, Maria E; Piras, Eugenia; Avanzini, Maria A; Regazzi, Mario; Locatelli, Franco

    2017-06-01

    Anti-T lymphocyte globulin (ATLG) modulates the alloreactivity of T lymphocytes, reducing the risk of immunological posttransplant complications, in particular rejection and graft-versus-host disease, after allogeneic hematopoietic stem cell transplantation (HSCT). We developed and validated a new enzyme-linked immunosorbent assay (ELISA) method to measure serum levels of total ATLG and evaluate the pharmacokinetics (PK) of the drug in children with β-Thalassemia, receiving allogeneic HSCT. Diluted serum samples were incubated with Goat-anti-Rabbit IgG antibody coated on a microtiter plate and then, with Goat-anti-Human IgG labeled with horseradish peroxidase. After incubation and washings, substrate solution was added and absorbance was read at 492 nm. ATLG concentrations in samples were determined by interpolation from a standard curve (range: 200-0.095 ng/mL), prepared by diluting a known amount of ATLG in phosphate-buffered saline (PBS). Low, medium, and high-quality control concentrations were 1.56, 6.25, and 25 ng/mL, respectively. This method was developed and validated within the acceptance criteria in compliance with the Guidelines for a biological method validation: the sensitivity of the method was 0.095 ng/mL. We analyzed serum samples from 14 children with β-Thalassemia who received ATLG (Grafalon) at a dose of 10 mg/kg administered as intravenous (IV) infusion on days -5, -4, and -3 before HSCT (day 0). Blood sampling for PK evaluation was performed on days -5, -4, and -3 before and after drug infusion; and then from day -2 to +56. The median total ATLG levels pre-IVand post-IV were 0 and 118 mcg/mL on day -5; 85.9 and 199.2 mcg/mL on day -4; 153 and 270.9 mcg/mL on day -3, respectively. The median PK values of CL was 0.0029 (range: 0.0028-0.0057) L·kg·d, Vd was 0.088 (range: 0.025-0.448) L/kg and t1/2 was 20.2 (range: 5.8-50.2) days. These data suggest that given the marked interindividual variability of total ATLG disposition, the development of

  14. Deficiency and toxicity of boron: Alterations in growth, oxidative damage and uptake by citrange orange plants.

    Science.gov (United States)

    Shah, Asad; Wu, Xiuwen; Ullah, Abid; Fahad, Shah; Muhammad, Riaz; Yan, Lei; Jiang, Cuncang

    2017-11-01

    Boron (B) deficiency and toxicity are the major factors that affect plant growth and yield. The present study revealed the effect of B deficiency and toxicity on plant growth, morphology, physiology, and cell structure. A hydroponic culture experiment was conducted with five B levels, B deficient (B0), sufficient (B20, B10, B40) and toxic (B100). Our results show that both B deficient as well as excess level inhibit plant growth. In B deficiency, the major visible symptoms were appeared in roots, while B excess burned the leaf margin of older leaves. The antioxidant enzymes including superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) decreased at B deficiency and also decreased up to some extent at B excess, while in sufficient treatments, the higher antioxidant enzymes were found at B20. In addition, the MDA concentration decreased at B deficiency and increased with B concentration. Moreover, the photosynthetic rate, transpiration rate, stomatal conductance, leaf gas exchange and intercellular CO 2 were reduced at both B deficiency as well as excess and higher at sufficient B20 treatment significantly. The chlorophyll and carotenoid content increased at B20 treatment, while decreased at B deficiency and excess. The middle lamellae of cell wall were found thick at B excess and normal at B20. The current study revealed that B deficiency as well as excess concentration affect plant growth and various morpho-physiological processes. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Addition of ketamine or dexmedetomidine to lignocaine in intravenous regional anesthesia: A randomized controlled study

    Directory of Open Access Journals (Sweden)

    Alok Kumar

    2012-01-01

    Results: Shortened sensory and motor block onset times (69.17 min and 7.83 min respectively, P < 0.0001 and improved quality of anesthesia (satisfaction score = 3, P < 0.05 were found in ketamine group. Visual analog scale scores (3.21 ± 0.41 were comparable while time to first analgesic requirement (166.25 ± 25.89 min, P < 0.0001 was significantly longer in dexmedetomidine group after tourniquet release. Conclusion: We conclude that the addition of 1 mcg/kg of body weight dexmedetomidine or 0.5 mg/kg of body weight ketamine to lignocaine for IVRA improves quality of anesthesia and perioperative analgesia without causing side effects. We considered ketamine reduced the time for onset of block, delayed the onset of tourniquet pain, and reduced postoperative analgesic requirement and had a better patient satisfaction than placebo or dexmedetomidine.

  16. A comparison of three vasopressors for tight control of maternal blood pressure during cesarean section under spinal anesthesia: Effect on maternal and fetal outcome

    Directory of Open Access Journals (Sweden)

    Neerja Bhardwaj

    2013-01-01

    Results: The umbilical pH was comparable in all the three groups (P > 0.05. The mean SBP from spinal block until delivery was similar over time for all the three groups. The incidence of reactive hypertension was more in group M (P < 0.05 than in group E and group P. Total drug consumption to meet target blood pressure till delivery was 39.3 ± 14.6 mg in group E, 1.7 ± 0.9 mg in group M, and 283.6 ± 99.8 mcg in group P. The incidence of nausea and vomiting was comparable in the three groups. Conclusion: All the three vasopressors were equally effective in maintaining maternal blood pressure as well as umbilical pH during spinal anesthesia for cesarean section without any detrimental effects on fetal and maternal outcome.

  17. Expression of a mineral phosphate solubilizing gene from Erwinia herbicola in two rhizobacterial strains.

    Science.gov (United States)

    Rodríguez, H; Gonzalez, T; Selman, G

    2001-11-30

    A genetic construction was carried out using the broad host range vector pKT230 and plasmid pMCG898, which encodes the Erwinia herbicola pyrroloquinoline quinone (PQQ) synthase, a gene involved in mineral phosphate solubilization (mps). The final construction was transformed and expressed in Escherichia coli MC1061, and the recombinant plasmids were transferred to Burkholderia cepacia IS-16 and Pseudomonas sp. PSS recipient cells by conjugation. Clones containing recombinant plasmids produced higher clearing halos in plates with insoluble phosphate as the unique (P) source, in comparison with those of strains without plasmids, demonstrating the heterologous expression of the E. herbicola gene in the recipient strains. This genetic manipulation allowed the increase in mps ability of both strains, enhancing their potentialities as growth promoters of agricultural crops. These results represent the first report on the application of the recombinant DNA methodology for the obtaining of improved phosphate solubilizing ability from rhizobacterial strains for biofertilization purposes.

  18. Intranasal dexmedetomidine for adrenergic crisis in familial dysautonomia.

    Science.gov (United States)

    Spalink, Christy L; Barnes, Erin; Palma, Jose-Alberto; Norcliffe-Kaufmann, Lucy; Kaufmann, Horacio

    2017-08-01

    To report the use of intranasal dexmedetomidine, an α 2 -adrenergic agonist for the acute treatment of refractory adrenergic crisis in patients with familial dysautonomia. Case series. Three patients with genetically confirmed familial dysautonomia (case 1: 20-year-old male; case 2: 43-year-old male; case 3: 26-year-old female) received intranasal dexmedetomidine 2 mcg/kg, half of the dose in each nostril, for the acute treatment of adrenergic crisis. Within 8-17 min of administering the intranasal dose, the adrenergic crisis symptoms abated, and blood pressure and heart rate returned to pre-crises values. Adrenergic crises eventually resumed, and all three patients required hospitalization for investigation of the cause of the crises. Intranasal dexmedetomidine is a feasible and safe acute treatment for adrenergic crisis in patients with familial dysautonomia. Further controlled studies are required to confirm the safety and efficacy in this population.

  19. Yoğun Bakımda Hafif Şiddetli Bir Propofol İnfüzyon Sendromu

    OpenAIRE

    Tezcan, Aysu Hayriye; Oterkus, Mesut; Donmez, Ilksen; Ozturk, Omur; Yavuzekinci, Zeynep

    2018-01-01

    Propofol infüzyon sendromu (PRİS) nadir ama ölümcül bir hastalıktır. Bu sendrom çoğunlukla ilacın yüksek dozda uzun süreli infüzyonundan sonra oluşur. Metabolik asidoz, hipotansiyon, miyoglobinüri, artmış karaciğer ve kas enzimleri, kardiyak aritmiler ve kalp durması sendromun genel özellikleridir. Bu olgu sunumunda uzun süreli düşük doz (25–50 mcg/kg/dk) ilaç infüzyonundan sonra ortaya çıkan hafif tipte bir PRİS tartışılmıştır. Bu olguda ilaç infüzyonu esnasında ciddi metabolik asidoz, hipot...

  20. Use of sodium nitroprusside in neurosurgical cases during anesthesia with enflurane.

    Science.gov (United States)

    Vandesteene, A; Mouawad, E; Noterman, J; Deloof, T; Ewalenko, P; Genette, F

    1980-01-01

    In patients operated for cerebral aneurysm or angioma, the same basic method of anesthesia has been used. Premedication consisted of Thalamonal or diazepam. After induction with thiopentone, curarisation with pancuronium and tracheal intubation, anesthesia was maintained with N2O 70%, O2 30% and enflurane 1%. Small doses of fentanyl or Thalamonal were given at the beginning of anesthesia, but no more within 30 minutes before starting controlled hypotension. Adjuvant drugs and methods to reduce intracranial pressure were also used, such as dexamethasone, mannitol and cerebro-spinal fluid subtraction. The approach and dissection of the vascular lesion was done under controlled hypotension with sodium nitroprusside 0.01% solution. The mean dose of sodium nitroprusside to maintain a mean blood pressure at about 50 Torr was 1.37 mcg/kg/min.

  1. [Vitamin-antioxidant sufficiency of winter sports athletes].

    Science.gov (United States)

    Beketova, N A; Kosheleva, O V; Pereverzeva, O G; Vrzhesinskaia, O A; Kodentsova, V M; Solntseva, T N; Khanfer'ian, R A

    2013-01-01

    The sufficiency of 169 athletes (six disciplines: bullet shooting, biathlon, bobsleigh, skeleton, freestyle skiing, snowboarding) with vitamins A, E, C, B2, and beta-carotene has been investigated in April-September 2013. All athletes (102 juniors, mean age--18.5 +/- 0.3 years, and 67 adult high-performance athletes, mean age--26.8 +/- 0.7 years) were sufficiently supplied with vitamin A (70.7 +/- 1.7 mcg/dl). Mean blood serum retinol level was 15% higher the upper limit of the norm (80 mcg/dl) in biathletes while median reached 90.9 mcg/dl. Blood serum level of tocopherols (1.22 +/- 0.03 mg/dl), ascorbic acid (1.06 +/- 0.03 mg/dl), riboflavin (7.1 +/- 0.4 ng/ml), and beta-carotene (25.1 +/- 1.7 mcg/dl) was in within normal range, but the incidence of insufficiency of vitamins E, C, B2, and carotenoid among athletes varied in the range of 0-25, 0-17, 15-67 and 42-75%, respectively. 95% of adults and 80% of younger athletes were sufficiently provided with vitamin E. Vitamin E level in blood serum of juniors involved in skeleton and biathlon was lower by 51 and 72% (p antioxidants (beta-carotene and vitamins E and C). In other sports, the relative quantity of athletes sufficiently supplied with these essential nutrients did not exceed 56%. The quota of supplied with all antioxidants among bullet shooters (31.1%) and bobsledders (23.5%) was significantly (p antioxidant (mainly beta-carotene) was most often recorded among persons engaged in bullet shooting (67%). The simultaneous lack of all three antioxidants was found only in freestylers and bobsledders (about 5%). Decreased level of antioxidants in blood serum in 40% of athletes was combined with vitamin B2 deficiency. The data obtained suggest the necessity to optimize diet vitamin content of all athletes, taking into account the age and gender differences. Contrary to prevailing stereotypes the optimization must involve not only an increase in the consumption of vitamins (vitamins E, B group) and carotenoids, but

  2. Myopathy Associated with Acute Hypothyroidism following Radioiodine Therapy for Graves Disease in an Adolescent

    Directory of Open Access Journals (Sweden)

    Rivkees ScottA

    2010-08-01

    Full Text Available We describe acute myopathy following I-131 treatment for hyperthyroidism due to Graves Disease (GD in an adolescent. A 15 year-old diagnosed with GD required treatment with radioactive iodine (I-131 therapy. Six weeks post I-131, he developed generalized muscle cramps. The CK was 19.800 U/L, the total thyroxine was 2.3 mcg/dL (29.6 nmol/L SI and the estimated free thyroxine (EFT was 0.5 ng/dL (6.4 pmol/L SI. The ALT was 112 U/L and AST was 364 U/L (normal

  3. Are oral emergency contraceptives a safe and effective form of long-term birth control?

    Science.gov (United States)

    Kraus, Connie; Hooper-Lane, Christopher

    2017-10-01

    Yes, but not as effective as some other methods. Annual pregnancy rates in women using pericoital levonorgestrel 150 mcg to 1 mg range from 4.9% to 8.9%; menstrual irregularity is the most common adverse effect (strength of recommendation [SOR]: B, Cochrane review of lower-quality trials). In women younger than 35 years who have sexual intercourse 6 or fewer times per month, correct and consistent use of pericoital levonorgestrel 1.5 mg results in an annual pregnancy rate of 11% (SOR: B, one large prospective, open-label trial). Pericoital contraception is less effective than long-acting reversible contraceptives (annual pregnancy rates of 0.05%-0.8%) or perfect use of combined oral contraceptives (0.3% annual pregnancy rate), but similar to, or better than, typical use of combined oral contraception (9%) and condoms (18%).

  4. Radioimmunoassay of thyroid related hormones in evaluation of secondary hypothyroidism in pituitary dwarfism

    International Nuclear Information System (INIS)

    Gembicki, M.; Kosowicz, J.; Sobieszczyk, S.

    1982-01-01

    The aim of our studies was the evaluation of thyroid function in 32 patients with idiopathic pituitary dwarfism. Serum T 4 , T 3 , reverse T 3 /rT 3 / and TSH were determined by radioimmunoassay. T 4 in pituitary dwarfs ranged from 0.6 to 7.6 ug/dl, T 3 was between 41 and 124 ng/dl and rT 3 ranged from 5 to 24 ng/dl. The ranges of T 4 , T 3 and rT 3 concentration were lower comparing with controls. In 18 patients a normal rise of TSH after TRH stimulation was observed, in 14 patients the response to TRH was absent or markedly decreased. Seven days administration of TRH, 200 mcg daily i.v. did not enhance pituitary response to TRH stimulation. These results indicate that in a nearly half of patients with idiopathic dwarfism secondary hypthyroidism develops as a results of insufficient TSH secretion. (Author)

  5. Ultrasound investigation central hemodynamics as a method of assessment effective analgesia in children

    Directory of Open Access Journals (Sweden)

    K. Y. Dmytriieva

    2016-06-01

    Vinnitsa National Medical University M.I. Pirogov   Summary: The study was include in 23 children (12,4±1,2 years operated on for tumors of the retroperitoneal space (14 children, 61%, renal tumors (6 children, 26%, ovarian cancer (3 children, 13% showed that a comprehensive study of the reactions of pain behavior and central hemodynamics by ultrasonography showed that the use of the scheme KSME bupivacaine 0.3-0.4 mg / kg and a continuous infusion of drugs (fentanyl in a dose of 10 mcg/kg/h for postoperative pain relief leads to effective analgesia after traumatic operations and comprehensive ultrasound including color and spectral Doppler studies, is the main tool by enabling timely and accurately assess the condition of the central hemodynamics at different methods of analgesia.   Key words: central hemodynamics, ultrasound, anesthesia.

  6. Reverberation Mapping of Optical Emission Lines in Five Active Galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Fausnaugh, M. M.; Denney, K. D.; Peterson, B. M.; Kochanek, C. S.; Pogge, R. W.; Brown, Jonathan S.; Coker, C. T. [Department of Astronomy, The Ohio State University, 140 W. 18th Avenue, Columbus, OH 43210 (United States); Grier, C. J.; Beatty, Thomas G. [Department of Astronomy and Astrophysics, The Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States); Bentz, M. C. [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30303 (United States); Rosa, G. De [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Adams, S. M. [Cahill Center for Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Barth, A. J. [Department of Physics and Astronomy, 4129 Frederick Reines Hall, University of California, Irvine, CA 92697 (United States); Bhattacharjee, A.; Brotherton, M. S. [Department of Physics and Astronomy, University of Wyoming, 1000 E. University Avenue, Laramie, WY (United States); Borman, G. A. [Crimean Astrophysical Observatory, P/O Nauchny, Crimea 298409 (Russian Federation); Boroson, T. A. [Las Cumbres Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Bottorff, M. C. [Fountainwood Observatory, Department of Physics FJS 149, Southwestern University, 1011 E. University Avenue, Georgetown, TX 78626 (United States); Brown, Jacob E. [Department of Physics and Astronomy, University of Missouri, Columbia (United States); Crawford, S. M. [South African Astronomical Observatory, P.O. Box 9, Observatory 7935, Cape Town (South Africa); and others

    2017-05-10

    We present the first results from an optical reverberation mapping campaign executed in 2014 targeting the active galactic nuclei (AGNs) MCG+08-11-011, NGC 2617, NGC 4051, 3C 382, and Mrk 374. Our targets have diverse and interesting observational properties, including a “changing look” AGN and a broad-line radio galaxy. Based on continuum-H β lags, we measure black hole masses for all five targets. We also obtain H γ and He ii λ 4686 lags for all objects except 3C 382. The He ii λ 4686 lags indicate radial stratification of the BLR, and the masses derived from different emission lines are in general agreement. The relative responsivities of these lines are also in qualitative agreement with photoionization models. These spectra have extremely high signal-to-noise ratios (100–300 per pixel) and there are excellent prospects for obtaining velocity-resolved reverberation signatures.

  7. Reverberation Mapping of the Continuum Source in Active Galactic Nuclei

    Science.gov (United States)

    Fausnaugh, Michael Martin

    variable to measure continuum-Hbeta lags and super-massive black hole masses: MCG+08-11-011, NGC 2617, NGC 4051, 3C 382, and Mrk 374. I also obtain Hgamma and HeII lags for all objects except 3C 382. The HeII lags indicate radial stratification of the BLR, and the masses derived from different emission lines are in general agreement. The relative responsivities of these lines to continuum variations are also in qualitative agreement with photoionization models. Finally, I measure optical continuum lags for the two most variable targets, MCG+08-11-011 and NGC 2617. I again find lags consistent with geometrically thin accretion-disk models that have temperature profiles T ∝ R-3/4. The observed lags are larger than predictions based on standard thin-disk theory by factors of 3.3 for MCG+08-11-011 and 2.3 for NGC 2617. Using a physical model, these differences can be explained if the mass accretion rates are larger than inferred from the optical continuum luminosity by a factor of 4.3 in MCG+08-11-011 and a factor of 1.3 in NGC 2617. While the X-ray variability in NGC 2617 precedes the UV/optical variability, the long 2.6 day lag is problematic for coronal reprocessing models.

  8. A short 2 week dose titration regimen reduces the severity of flu-like symptoms with initial interferon gamma-1b treatment.

    Science.gov (United States)

    Devane, John G; Martin, Mary L; Matson, Mark A

    2014-06-01

    Flu-like symptoms (FLS) are commonly experienced by patients receiving interferon gamma-1b which may cause discontinuation or disruption of dosing during initial therapy or on re-initiation following a break in therapy. In contrast to Type I interferons, the impact of dose-titration on FLS has not been reported and is not a practice described or included in the approved prescribing information for interferon gamma-1b.The objective of this study was to assess the effect of a 2 week titration regimen on the severity of FLS during the initial 3 weeks of therapy with three times weekly subcutaneous injections of interferon gamma-1b. Healthy men and women were randomized into a double-blind, two-period, crossover study. Each study period was 3 weeks in duration and there was a minimum 15 day washout between treatment periods. Two treatment regimens were compared: No Titration dosing (full 50 mcg/m(2) subcutaneously [s.c.] three times weekly for 3 weeks) and Titration (15 mcg/m(2) s.c. three times weekly during week 1, 30 mcg/m(2) s.c. three times weekly during week 2 followed by the full dose of 50 mcg/m(2) s.c. three times weekly during week 3). Subjects remained in the clinic for at least 12 hours following each injection. FLS was based on a composite score for fever, chills, tiredness and muscle aches assessed at baseline and 4, 8 and 12 hours following each injection. Acetaminophen was allowed at the discretion of the PI. The primary endpoint was the change from baseline in FLS severity at 8 hours averaged over the 3 weeks of treatment. Additional endpoints included FLS at 4 and 12 hours, individual flu-like symptoms, rates of discontinuation, incidence of FLS and acetaminophen use. NCT 01929382. Of the 40 subjects randomized, there were 15 (37.5%) discontinuations. Titration resulted in a significant reduction in FLS severity at 8 hours (p = 0.023) averaged over the 3 week treatment period. The difference in 3 week FLS severity reflects differences

  9. Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety.

    Science.gov (United States)

    Capeding, Rosario; Gepanayao, Connie P; Calimon, Nerrisa; Lebumfacil, Jowena; Davis, Anne M; Stouffer, Nicole; Harris, Bruce J

    2010-05-21

    Breast milk contains lutein derived from the mother's diet. This carotenoid is currently not added to infant formula, which has a small and variable lutein content from innate ingredients. This study was conducted to compare the growth of infants fed lutein-fortified infant formula with that of infants fed infant formula without lutein fortification. This 16-week study was prospective, randomized, controlled, and double-blind with parallel groups of healthy term infants fed either control formula (Wyeth S-26 Gold, designated as Gold) or experimental formula (Wyeth S-26 Gold fortified with lutein at 200 mcg/l, designated as Gold+Lutein). Two hundred thirty-two (232) infantslutein-fortified S-26 Gold demonstrated growth equivalent to that of infants fed unfortified lutein formula.

  10. Prediction of novel pre-microRNAs with high accuracy through boosting and SVM.

    Science.gov (United States)

    Zhang, Yuanwei; Yang, Yifan; Zhang, Huan; Jiang, Xiaohua; Xu, Bo; Xue, Yu; Cao, Yunxia; Zhai, Qian; Zhai, Yong; Xu, Mingqing; Cooke, Howard J; Shi, Qinghua

    2011-05-15

    High-throughput deep-sequencing technology has generated an unprecedented number of expressed short sequence reads, presenting not only an opportunity but also a challenge for prediction of novel microRNAs. To verify the existence of candidate microRNAs, we have to show that these short sequences can be processed from candidate pre-microRNAs. However, it is laborious and time consuming to verify these using existing experimental techniques. Therefore, here, we describe a new method, miRD, which is constructed using two feature selection strategies based on support vector machines (SVMs) and boosting method. It is a high-efficiency tool for novel pre-microRNA prediction with accuracy up to 94.0% among different species. miRD is implemented in PHP/PERL+MySQL+R and can be freely accessed at http://mcg.ustc.edu.cn/rpg/mird/mird.php.

  11. Severe Hypoglycemia due to Isolated ACTH Deficiency in Children: A New Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Michael Y. Torchinsky

    2011-01-01

    Full Text Available Isolated ACTH deficiency causes life-threatening severe hypoglycemia. A 7-year-old girl with hypoglycemia due to this rare disorder is described. Our patient had undetectable plasma ACTH repeatedly and cortisol 0 mcg/dl before and after ACTH 1-24 stimulation. There was no evidence of other pituitary hormone deficiency. Glucocorticoid replacement therapy resulted in resolution of all symptoms and normalization of blood glucose. Previously published data on isolated ACTH deficiency in children is summarized. Review of the literature showed that the prevalence of this condition could be underestimated in the neonatal period and in Prader-Willi syndrome. Isolated ACTH deficiency occurs in older children as well as in neonates.

  12. Room temperature deformation mechanisms in ultrafine-grained materials processed by hot isostatic pressing

    International Nuclear Information System (INIS)

    Cao, W.Q.; Dirras, G.F.; Benyoucef, M.; Bacroix, B.

    2007-01-01

    Ultrafine-grained (uf-g) and microcrystalline-grained (mc-g) irons have been fabricated by hot isostatic pressing of nanopowders. The mechanical properties have been characterized by compressive tests at room temperature and the resulting microstructures and textures have been determined by combining electron back scatter diffraction and transmission electron microscopy. A transition of the deformation mode, from work hardening to work softening occurs for grain sizes below ∼1 μm, reflecting a transition of the deformation mode from homogeneous to localized deformation into shear bands (SBs). The homogeneous deformation is found to be lattice dislocation-based while the deformation within SBs involves lattice dislocations as well as boundary-related mechanisms, possibly grain boundary sliding accommodated by boundary opening

  13. Obstetric use of nitroglycerin: Anesthetic implications

    Directory of Open Access Journals (Sweden)

    Richa Saroa

    2013-01-01

    Full Text Available Nitroglycerin has been used in anesthetic practice for induced hypotension and managing perioperative hypertension and myocardial ischemia. Contrary to the continuous low dose infusions (5-20 mcg/min used for the same, intravenous bolus dosages are sometimes administered at the behest of obstetricians for removal of retained placenta. Use of nitroglycerine in managing retained placenta is undertaken as a last resort when other measures fail to relax the uterine smooth muscles. Intravenous nitroglycerine relaxes smooth muscle cells by releasing nitric oxide thus causing prompt cervico-uterine relaxation. However, administration of nitroglycerine in this manner is not without risks which should be kept in mind while using it for obstetric purposes. We hereby report a case of 22-year-old female scheduled for manual removal of placenta where unpredictable and unexpected hypoxemia was observed following nitroglycerine administration.

  14. Statefinder diagnostic for modified Chaplygin gas cosmology in f(R,T) gravity with particle creation

    Science.gov (United States)

    Singh, J. K.; Nagpal, Ritika; Pacif, S. K. J.

    In this paper, we have studied flat Friedmann-Lemaître-Robertson-Walker (FLRW) model with modified Chaplygin gas (MCG) having equation of state pm = Aρ ‑ B ργ, where 0 ≤ A ≤ 1, 0 ≤ γ ≤ 1 and B is any positive constant in f(R,T) gravity with particle creation. We have considered a simple parametrization of the Hubble parameter H in order to solve the field equations and discussed the time evolution of different cosmological parameters for some obtained models showing unique behavior of scale factor. We have also discussed the statefinder diagnostic pair {r,s} that characterizes the evolution of obtained models and explore their stability. The physical consequences of the models and their kinematic behaviors have also been scrutinized here in some detail.

  15. Evaluation of the effectiveness of diabetic nephropathy stage III in patients with type 2 diabetes mellitus therapy with sulodexide

    Directory of Open Access Journals (Sweden)

    V. G. Kadzharyan

    2013-08-01

    were men. In 20 patients from the group alimentary-constitutional obesity was noted. II group consisted of 11 people: 4 women and 7 men, aged 48 to 68 years, 6 of which were suffering from alimentary-constitutional obesity. Patients received standard treatment of type 2 diabetes and hypertension. In group I, sulodexide (600 LPL units intramuscularly 1 time per day for 10 days was further included. The research of microalbuminuria (MAU was conducted on admission and on the 10th day of treatment. Results. The initial values of MAU in 1st group were 92,7 ± 25,2 mcg/min. In the dynamics of monitoring rates decreased to 44,4 ± 9,6 mcg/min. The degree of decrease was 47% (p <0.05. In 2nd Group MAU initial values were 46,7 ± 23,4 mcg/min. In the dynamics of monitoring MAU decreased to 29,5 ± 12,6 mcg/min. Degree of decrease was 27% (p <0.05 Conclusions. 1 In patients with stage III DN with diabetes type 2 by including in the basic therapy of sulodexide level MAU was reliable decreased on 47%, which is on 20% lower than in the comparison group (p <0.05. 2 During the research reliable direct dependence of decreased MAU rates with its initial values and degree of obesity was found. It indicates the increase in the effectiveness of the drug at a higher initial level of MAU in people with overweight.

  16. Lumbar neuropathic pain of lower limbs treated by spinal infusion of ziconotide a case – report

    Directory of Open Access Journals (Sweden)

    Luca Quadrino

    2008-09-01

    Full Text Available The Author reports the case of a patient with severe lumbar pain unresponsive to NSAIDs. Initial treatment with tramadol gave poor results and a new protocol with hydromorphone – pregabalin was started. The analgesic response was observed only following high hydromorphone doses, associated with unacceptable side effects. A spinal device for continuous intrathecal infusion was then implanted, in order to administer ziconotide, a new opioid drug. Associated therapy included hydromorphone – pregabalin. At the 4 mcg/die dose ziconotide resulted highly effective (with a VAS reduction pain 6-7 to 2-3 even at 1st day after implantation; in addition at day 10, opioid dose was strongly reduced and pregabalin withdrawn. The treatment was associated with a good tolerability. The encouraging results prompted the Author to test ziconotide in further cases of severe chronic pain.

  17. Cambios proyectados de los recursos hídricos bajo escenarios de emisiones RCP4.5 y 8.5 de modelos climáticos globales del CMIP5 en el Altiplano Peruano

    OpenAIRE

    Lujano Laura, Efrain; Servicio Nacional de Meteorología e Hidrología; Hidalgo Sanchez, Liz S.; Servicio Nacional de Meteorología e Hidrología; Tapia Aguilar, Bernardino; Servicio Nacional de Meteorología e Hidrología; Lujano Laura, Apolinario; Autoridad Nacional del Agua; Diaz Aguilar, Renny D.; Servicio Nacional de Meteorología e Hidrología

    2016-01-01

    La investigación, se realizó en el ámbito del altiplano Peruano, con el objetivo de evaluar los cambios en la disponibilidad del recurso hídrico bajo escenarios de emisiones de Modelos Climáticos Globales (MCG) del Proyecto de Intercomparación de Modelos Acoplados Fase 5 (CMIP5). La distribución espacio-temporal de la precipitación, se tomó como referencia la climatología 1971 – 2000 y sus proyecciones para el horizonte 2071 – 2100, así mismo para la simulación de caudales se utilizó el model...

  18. Reverberation Mapping of Optical Emission Lines in Five Active Galaxies

    International Nuclear Information System (INIS)

    Fausnaugh, M. M.; Denney, K. D.; Peterson, B. M.; Kochanek, C. S.; Pogge, R. W.; Brown, Jonathan S.; Coker, C. T.; Grier, C. J.; Beatty, Thomas G.; Bentz, M. C.; Rosa, G. De; Adams, S. M.; Barth, A. J.; Bhattacharjee, A.; Brotherton, M. S.; Borman, G. A.; Boroson, T. A.; Bottorff, M. C.; Brown, Jacob E.; Crawford, S. M.

    2017-01-01

    We present the first results from an optical reverberation mapping campaign executed in 2014 targeting the active galactic nuclei (AGNs) MCG+08-11-011, NGC 2617, NGC 4051, 3C 382, and Mrk 374. Our targets have diverse and interesting observational properties, including a “changing look” AGN and a broad-line radio galaxy. Based on continuum-H β lags, we measure black hole masses for all five targets. We also obtain H γ and He ii λ 4686 lags for all objects except 3C 382. The He ii λ 4686 lags indicate radial stratification of the BLR, and the masses derived from different emission lines are in general agreement. The relative responsivities of these lines are also in qualitative agreement with photoionization models. These spectra have extremely high signal-to-noise ratios (100–300 per pixel) and there are excellent prospects for obtaining velocity-resolved reverberation signatures.

  19. Effects of pelvic telecobalt irradiation on gonadotropin secretin

    International Nuclear Information System (INIS)

    Pfenninger, R.

    1978-01-01

    The pitnitary reaction in women operated according to Wertheim who had menstruated regularly was investigated during telecobalt irradiation. The pitnitary reaction was observed with the aid of the gonadotropin releasing factor. A dose of 25 mcg RH-LH was applied. Releasing factor examinations were carried out before exposure with functioning ovaries, after a dose of 2000 R (i.e., after 10 exposures), and after 6000 R. In the meantime, separate gonadotropin examinations were carried out continuously. A FSH reaction was observed already after 14 days, and the values were raised to almost menopause values. After this, the FSH increased further, while the LH reaction was not observed until much later. The investigation suggests an interrelation between follicle apparatus and FSH, oestrogens and LH. (orig./AJ) [de

  20. Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole

    Directory of Open Access Journals (Sweden)

    Emel Altuncu

    2015-01-01

    Full Text Available Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB treatment in spite of low MIC levels (MIC: 0.5 mcg/mL. Both of the patients’ blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day. After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment.

  1. Continuum Reverberation Mapping of AGN Accretion Disks

    Energy Technology Data Exchange (ETDEWEB)

    Fausnaugh, Michael M. [Department of Astronomy, Ohio State University, Columbus, OH (United States); MIT Kavli Institute for Astrophysics and Space Research, Cambridge, MA (United States); Peterson, Bradley M. [Department of Astronomy, Ohio State University, Columbus, OH (United States); Center for Cosmology and AstroParticle Physics, Ohio State University, Columbus, OH (United States); Space Telescope Science Institute, Baltimore, MD (United States); Starkey, David A. [SUPA Physics and Astronomy, University of St. Andrews, Scotland (United Kingdom); Department of Astronomy, University of Illinois at Urbana-Champaign, Urbana, IL (United States); Horne, Keith, E-mail: faus@mit.edu [SUPA Physics and Astronomy, University of St. Andrews, Scotland (United Kingdom); Collaboration: the AGN STORM Collaboration

    2017-12-05

    We show recent detections of inter-band continuum lags in three AGN (NGC 5548, NGC 2617, and MCG+08-11-011), which provide new constraints on the temperature profiles and absolute sizes of the accretion disks. We find lags larger than would be predicted for standard geometrically thin, optically thick accretion disks by factors of 2.3–3.3. For NGC 5548, the data span UV through optical/near-IR wavelengths, and we are able to discern a steeper temperature profile than the T ~ R{sup −3/4} expected for a standard thin disk. Using a physical model, we are also able to estimate the inclinations of the disks for two objects. These results are similar to those found from gravitational microlensing of strongly lensed quasars, and provide a complementary approach for investigating the accretion disk structure in local, low luminosity AGN.

  2. A SQUID gradiometer module with wire-wound pickup antenna and integrated voltage feedback circuit

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Guofeng [State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences (CAS), Shanghai 200050 (China); Peter Gruenberg Institute (PGI-8), Forschungszentrum Juelich (FZJ), D-52425 Juelich (Germany); Joint Research Laboratory on Superconductivity and Bioelectronics, Collaboration between CAS-Shanghai and FZJ, Shanghai 200050 (China); Graduate University of the Chinese Academy of Sciences, Beijing 100049 (China); Zhang, Yi, E-mail: y.zhang@fz-juelich.de [Peter Gruenberg Institute (PGI-8), Forschungszentrum Juelich (FZJ), D-52425 Juelich (Germany); Joint Research Laboratory on Superconductivity and Bioelectronics, Collaboration between CAS-Shanghai and FZJ, Shanghai 200050 (China); Zhang Shulin [State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences (CAS), Shanghai 200050 (China); Joint Research Laboratory on Superconductivity and Bioelectronics, Collaboration between CAS-Shanghai and FZJ, Shanghai 200050 (China); Krause, Hans-Joachim [Peter Gruenberg Institute (PGI-8), Forschungszentrum Juelich (FZJ), D-52425 Juelich (Germany); Joint Research Laboratory on Superconductivity and Bioelectronics, Collaboration between CAS-Shanghai and FZJ, Shanghai 200050 (China); and others

    2012-10-15

    The performance of the direct readout schemes for dc SQUID, Additional Positive Feedback (APF), noise cancellation (NC) and SQUID bootstrap circuit (SBC), have been studied in conjunction with planar SQUID magnetometers. In this paper, we examine the NC technique applied to a niobium SQUID gradiometer module with an Nb wire-wound antenna connecting to a dual-loop SQUID chip with an integrated voltage feedback circuit for suppression of the preamplifier noise contribution. The sensitivity of the SQUID gradiometer module is measured to be about 1 fT/(cm {radical}Hz) in the white noise range in a magnetically shielded room. Using such gradiometer, both MCG and MEG signals are recorded.

  3. Levothyroxine Improves Subjective Sleepiness in a Euthyroid Patient with Narcolepsy without Cataplexy

    Science.gov (United States)

    Sobol, Danielle L.; Spector, Andrew R.

    2014-01-01

    Objective: We discuss the use of levothyroxine for excessive daytime sleepiness (EDS) and prolonged nocturnal sleep time in a euthyroid patient with narcolepsy. Methods: After failure of first-line narcolepsy treatments, a 48-year-old female began levothyroxine (25 mcg/day). After 12 weeks of treatment, the patient was evaluated for improvement in total sleep time and subjective daytime sleepiness assessed by Epworth Sleepiness Scale (ESS). Results: At baseline, ESS score was 16 and total sleep time averaged 16 h/day. After 12 weeks, ESS was 13 and reported total sleep time was 13 h/day. Conclusions: Levothyroxine improved EDS and total sleep time in a euthyroid patient with narcolepsy without cataplexy after 12 weeks without side effects. Citation: Sobol DL, Spector AR. Levothyroxine improves subjective sleepiness in a euthyroid patient with narcolepsy without cataplexy. J Clin Sleep Med 2014;10(11):1231-1232. PMID:25325591

  4. Current concepts on the use of IUDs.

    Science.gov (United States)

    McCarthy, T

    1989-08-01

    IUDs have been used in Singapore since the mid 1960's but acceptance of this contraceptive method has fluctuated widely as a result of misconceptions regarding possible complications. The current generation of copper bearing devices have pregnancy rates below 1 per 100 women per year and this rate falls further with continued use. New developments which hold promise include a device releasing 20 mcg levonorgestrel per day and a copper device without a plastic frame which may reduce menstrual blood loss and dysmenorrhoea. In addition to the well established contra-indications to use, a past history of pelvic inflammatory disease or ectopic pregnancy, promiscuity, nulliparity and age less than 25 are now considered relative contraindications.

  5. Effectiveness of combined antyviral therapy in children with chronic hepatitis C

    Directory of Open Access Journals (Sweden)

    G. P. Martynova

    2013-01-01

    Full Text Available The paper presents the results of the research on effectiveness of combined antiviral therapy conducted with pegylated interferon alpha 2b of prolonged action (Peginterferon alpha 2b at a dose of 60 mcg/m2 per week and Rebetol (Ribavirin at a dose of 15 mg/kg per day in 26 children with chronic viral hepatitis C aged from 3 to 17, who underwent regular medical check-ups in City Clinical Hospital № 20 named after I.S. Berzon in Krasnoyarsk. Evaluation of effectiveness of combined antiviral therapy revealed that patients with genotype 1 had an immediate virologic response in 78,5% of cases, 83,3% of patients with genotype 2, 3 had a stable virologic response.

  6. DAMAGE IN MOLYBDENUM ASSOCIATED WITH NEUTRON IRRADIATION AND SUBSEQUENT POST-IRRADIATION ANNEALING

    Energy Technology Data Exchange (ETDEWEB)

    Mastel, B.

    1963-07-23

    Molybdemum containing carbon was studied in an attempt to establish the combined effect of impurity content and neutron irradiation on the properties and structure of specific metals. Molybdenum foils were punched into discs and heat treated in vacuum. They were then slow-cooled and irradiated. After irradiation and subsequent decay of radioactivity to a low level the foils were subjected to x-ray diffraction measurements. Cold-worked foils with less than 10 ppm carbon showed no change in microstructure due to irradiation. Molybdenum foils that were annealed prior to irradiation showed spot defects. In foils containing up to 500 ppm carbon, it was concluded that the small loops present after irradiation are due to the clustering of point defects at interstitial carbon atoms, followed by collapse to form a dislocation loop. The amount of lattice expansion after irradiation was strongly dependent on impurity content. Neutron irradiation was found to reduce the number of active slip systems. (M.C.G.)

  7. Simultaneous UV Spectrophotometric Determination of Cetrizine and Dextromethorphan in Tablet Dosage Form

    Directory of Open Access Journals (Sweden)

    R. Vijayalakshmi

    2010-01-01

    Full Text Available Two accurate, precise, sensitve and economical procedures for simultaneous estimation of cetrizine and dextromethorphan in tablet dosage forms have been developed. First method employs formation and solving of simultaneous equations using 230 nm and 280 nm as two analytical wavelengths for both drugs in methanol. The second method is Q-analysis based on measurement of absorptivity at 224 nm (as isobestic point and 280 nm (λmax of CTZ. Cetrizine and dextromethorphan at their respective λmax 280 nm and 230 nm and at 224 nm (isobestic point shows linearity in a concentration range of 10-30 mcg/mL for both the drugs. The recovery studies confirmed accuracy of the proposed methods and low values of standard deviation confirmed precision of the methods. The methods were validated as per ICH guidelines.

  8. [Thyroid status peculiarities of elderly patients 5 years after operation depending on the volume of surgical intervention].

    Science.gov (United States)

    Aristarhov, V G; Danilov, N V; Aristarkhov, R V; Puzin, D A; Birykov, C V

    2016-01-01

    Long-term results of treatment of 180 patients operated 5 years ago for benign thyroid nodular pathology have been analyzed in the present paper, the results being analyzed depending on the volume of surgical intervention. The rate of postoperative hypothyrodism is lower in patients who had undergone limited thyroid resection, recurrent cases are more frequent, but they are not clinically significant and seldom require reoperation. It should also be noted that those patients have fewer cardiac complaints as the dose of hormone replacement therapy preparations is small. Elder patients who had undergone functionally significant thyroidectomy and need to take great doses of Thyroxin (107-150 mcg/day) have cardiac complaints more often (43 %) comparing to those who had undergone limited resections (35 %).

  9. Nutrient consumption pattern of male soccer players in Shiraz/Iran

    Directory of Open Access Journals (Sweden)

    Saeed Najafpour Bushehry

    2003-09-01

    Full Text Available Exercise and nutrition have a significant impact on health. To evaluate nutrient consumption pattern of soccer players in city of Shiraz, 323 players were selected by proportional multi-stage cluster random sampling from 11 clubs in Shiraz. Anthropometric indices, socioeconomic status, 24 hours dietary recall and food frequency data were collected. Protein, carbohydrate and fat intake of the players were 73.73 gr (10.8%, 493.3 gr (72.4% and 50.8 gr (16.7%, respectively. Calcium (689.6 mg, phosphorus (734.4 mg, iron (20.3 mg, vitamin B1 (2 mg, vitamin B2 (1.6 mg, vitamin C (107.5 mg and vitamin A (962.4 mcg RE intake were lower than the desirable levels. The mean energy consumption of the players was 2723 Kcal per day. In conclusion, protein and micronutrients intakes are not desirable in Iranian soccer players in Shiraz.

  10. Anisotropic exchange interaction for magnetic ion pairs in insulators

    International Nuclear Information System (INIS)

    Passeggi, M.C.G.

    1975-12-01

    The sources of possible contributions to the magnetic anisotropy for a pair of orbitally non degenerate magnetic ions are investigated. The problem being formulated with the help of the operator form of perturbation theory and irreducible tensor operators. Apart from the usual dipole-dipole effective interaction, mainly induced by the electronic spin-spin dipole coupling corrected by covalency, other mechanisms mediated by the spin-orbit coupling appear. These are a consequence of an appropriate description of the spin-orbit operators for a system which allows for delocalization of the magnetic electrons. A process similar to that known as pseudodipolar appears from contributions in which spin orbit combined with the Coulomb repulsion and with one-electron interactions (acting analogously as for the ''kinetic exchange'') produce compensating effects in third and fourth order, respectively. However, this effect does not appear to be describable in terms of the phenomenological exchange, as is usually assumed. (Passeggi, M.C.G.)

  11. Oral clefts and life style factors - a case-cohort study based on prospective Danish data

    DEFF Research Database (Denmark)

    Bille, Camilla; Olsen, Jørn; Vach, Werner

    2007-01-01

    supplementation with > or =400 mcg folic acid daily during the entire first trimester (OR: 0.75; CIs: 0.46, 1.22) suggested an inverse associated with oral clefts, similar to our results on coffee drinking. No effects were found for smaller doses of folic acid, vitamin A, B6 or B12 in this study. The present......This study examines the association between oral clefts and first trimester maternal lifestyle factors based on prospective data from the Danish National Birth Cohort. The cohort includes approximately 100,000 pregnancies. In total 192 mothers gave birth to child with an oral cleft during 1997......-2003. Information on risk factors such as smoking, alcohol consumption, tea, coffee, cola, and food supplements was obtained during pregnancy for these and 828 randomly selected controls. We found that first trimester maternal smoking was associated with an increased risk of oral clefts (odds ratio (OR): 1.50; 95...

  12. Effect of Biodiesel of Spent Cooking Oil Addition at Diesel Fuel to Opacity and Gas Emission Throw Away of CO, CO2 and HC

    International Nuclear Information System (INIS)

    Setyadji, Moch; Endang Susiantini

    2007-01-01

    Investigation of biodiesel spent cooking oil addition effect at diesel fuel to opacity and gas emission throw away on various engine rotation speed has been done. The variables observed were fuel specific used i.e. pure diesel fuel, biodiesel mix 5% (B5), mix 10% (B10), mix 15% (B15), mix 20% (B20) and engine rotation speed. Gas emission throw away observed were CO, CO 2 , HC and opacity. Opacity and gas emission throwaway were observed by Opacity Sagem apparatus and gas analyzer. Result of experiment showed that biodiesel addition at diesel fuel was very decreasing opacity and gas emission throw away. The opacity lowest on B20, gas emission throw away lowest of CO on B10, CO 2 on B10 and HC on B20. (author)

  13. Structure of boron clusters revisited, Bn with n = 14-20

    Science.gov (United States)

    Tai, Truong Ba; Tam, Nguyen Minh; Nguyen, Minh Tho

    2012-03-01

    We reinvestigate the structures of neutral boron clusters Bn, with n = 14-20. G3B3 calculations confirm that a transition between 2D and 3D shape occurs at B20, which has a tubular form. In disagreement with Boustani et al. (Phys. Rev. B, 83 (2011) 193405), we find a planar B19 cluster. Standard heats of formation are obtained and used to evaluate the clusters stability. The average binding energy tends to increase with increasing size toward a limit. Higher stability is found B14, B16, B18 and B20. All Bn have negative NICS-values. The bonding nature and electron delocalization of B20 are re-examined using CMO and LOL.

  14. A study of preclinical myocardial damage in diabetes mellitus

    International Nuclear Information System (INIS)

    Mizuno, Sumio

    1986-01-01

    The scintigrams were evaluated by visual and circumferential profile analysis. In addition, mechanocardiography (MCG) and functional tests of the autonomic nerves were done. Coronary angiography and left ventriculography (LVG) were performed in 22 patients having cardiac symptoms. Of 61 patients, 20 (32, 8 %) showed perfusion defects in the scintigram (positive cases), consisting of 5 with stress-induced defect and 15 with fixed defect. The scintigrams in 41 patients showed normal perfusion of thallium (negative cases). The positive cases had more severe diabetic complications and longer duration of diabetes compared with the negative cases. The positive cases were incident to the treatment with insulin or oral drugs. Both systolic time intervals (STIs) in MCG and coefficients of variation of heart rate (CV) decreased in the diabetics, particularly in the positive cases. However, the decrement of STIs and CV was not significantly different in quantity between positive and negative cases; results therefore suggest that these two parameters may not correlate directly with the perfusion defects on Tl-201 scintigraphy. Twenty-two patients, 9 positive and 13 negative cases, had undergone cardiac catheterization, and showed normal coronary angiograms. On hemodynamic study, an ejection fraction decreased more in the positive cases than in the negative cases. The 13 negative cases showed normal wall motion in the LVG. Seven of the 9 positive cases, however, showed local hypokinetic wall motion. Abnormalities of the LVG corresponded to findings of the scintigram, i. e., perfusion defects or decrement of washout rate. On circumferential profile analysis, the mean washout rate of the whole heart decreased only in the positive cases. (J.P.N.)

  15. Initial Serum Ferritin Predicts Number of Therapeutic Phlebotomies to Iron Depletion in Secondary Iron Overload

    Science.gov (United States)

    Panch, Sandhya R.; Yau, Yu Ying; West, Kamille; Diggs, Karen; Sweigart, Tamsen; Leitman, Susan F.

    2014-01-01

    Background Therapeutic phlebotomy is increasingly used in patients with transfusional siderosis to mitigate organ injury associated with iron overload (IO). Laboratory response parameters and therapy duration are not well characterized in such patients. Methods We retrospectively evaluated 99 consecutive patients undergoing therapeutic phlebotomy for either transfusional IO (TIO, n=88; 76% had undergone hematopoietic transplantation) or non-transfusional indications (hyperferritinemia or erythrocytosis) (n=11). CBC, serum ferritin (SF), transferrin saturation, and transaminases were measured serially. Phlebotomy goal was an SF< 300 mcg/L. Results Mean SF prior to phlebotomy among TIO and nontransfusional subjects was 3,093 and 396 mcg/L, respectively. Transfusion burden in the TIO group was 94 ± 108 (mean ± SD) RBC units; about half completed therapy with 24 ± 23 phlebotomies (range 1–103). One-third was lost to follow-up. Overall, 15% had mild adverse effects, including headache, nausea, and dizziness, mainly during first phlebotomy. Prior transfusion burden correlated poorly with initial ferritin and total number of phlebotomies to target (NPT) in the TIO group. However, NPT was strongly correlated with initial SF (R2=0.8; p<0.0001) in both TIO and nontransfusional groups. ALT decreased significantly with serial phlebotomy in all groups (mean initial and final values, 61 and 39 U/L; p = 0.03). Conclusions Initial SF but not transfusion burden predicted number of phlebotomies to target in patients with TIO. Despite good treatment tolerance, significant losses to follow-up were noted. Providing patients with an estimated phlebotomy number and follow-up duration, and thus a finite endpoint, may improve compliance. Hepatic function improved with iron off-loading. PMID:25209879

  16. To study the effect of injection dexmedetomidine for prevention of pain due to propofol injection and to compare it with injection lignocaine

    Directory of Open Access Journals (Sweden)

    Manisha Sapate

    2015-12-01

    Full Text Available BACKGROUND: Pain due to injection propofol is a common problem. Different methods are used to decrease the pain but with limited success. The objective of this study was to assess the effect of injection dexmedetomidine 0.2 mcg/kg for prevention of pain due to propofol injection and compare it with injection lignocaine 0.2 mg/kg. METHOD: After taking permission of the Institutional Ethical Committee, written informed consent was obtained from all patients, in a randomized prospective study. 60 American Society of Anesthesiology I and II patients of age range 20-60 years of either sex posted for elective surgeries under general anaesthesia were randomly allocated into two groups. Group I (dexmedetomidine group: Inj. dexmedetomidine 0.2 mcg/kg diluted in 5 mL normal saline and Group II (lignocaine group: Inj. lignocaine 0.2 mg/kg diluted in 5 mL normal saline. IV line was secured with 20 G cannula and venous occlusion was applied to forearm using a pneumatic tourniquet and inflated to 70 mm Hg for 1 min. Study drug was injected, tourniquet released and then 25% of the calculated dose of propofol was given intravenously over 10 s. After 10 s of injection, severity of pain was evaluated using McCrirrick and Hunter scale and then remaining propofol and neuromuscular blocking agent was given. Endotracheal intubation was done and anaesthesia was maintained on O2, N2O and isoflurane on intermittent positive pressure ventilation with Bain's circuit and inj. vecuronium was used as muscle relaxant. RESULTS: Demographic data showed that there was no statistically significant difference between the 2 groups. There was no statistically significant difference between 2 groups in respect to inj. propofol pain. No adverse effects like oedema, pain, wheal response at the site of injection were observed in the two groups.

  17. Hyperhomocysteinemia - an additional risk factor of thrombosis in systemic lupus erythematosus and antiphospholipid syndrome

    Directory of Open Access Journals (Sweden)

    I. E. Shirokova

    2003-01-01

    Full Text Available Objective. To assess homocystein (HC level in systemic lupus erythematosus (SLE with antiphospholipid syndrome (APS and its relation to thrombosis development and blood lipide spectrum disturbances. Material and methods. 32 pts (12 male and 20 female with mean age 36 12 years and mean disease duration 13 11 years were included. 8 pts had SLE without APS, 13 - SLE with APS and 11 - primary APS (PAPS. All pts were divided into 2 groups depending on blood HC level. 26 pts with HC level more than 12 mcg/d! were included In group 1 and 6 pts with HC level less than 12 mcg/dl - in group 2. HC level was measured with high efficacious liquid chromatography (HELC. Lipid-protein blood spectrum was assessed in all pts. Results. Elevated HC level was revealed in 26 from 32 pts: in 16 with SLE (including 12 pts with APS and in 10 with PAPS. HC concentration did not depend on APS presence, but frequence of hyperhomocysteinemia (HHC significantly associated with APS and thrombotic complications. 20 from 26 (76,9% pts with HHC had thrombosis history. Only I from 6 (16,7% pts with normal HC level had thrombosis history (exact Fisher test p=0,02. HC level did not depend on age and sex. Changes of blood lipid-protein indices were revealed in most pts. Lipid spectrum disturbances were confined largely to cholesterol elevation due to increase of atherogenic lipoproteins cholesterol. Only 22% of pts showed decrease of antiatherogenic lipoproteins concentration. Bblood lipid-protein spectrum indices did not depend on HC level. Conclusion. HHC is present in 84,6% of pts with APS (primary and secondary. In pts with APS HHC is more frequent than in pts without APS. HHC is associated with thrombotic complications. HHC and lipid-protein spectrum disturbances are independent risk factors of thrombotic complications in pts with SLE and APS.

  18. Laboratory Plasma Source as an MHD Model for Astrophysical Jets

    Science.gov (United States)

    Mayo, Robert M.

    1997-01-01

    The significance of the work described herein lies in the demonstration of Magnetized Coaxial Plasma Gun (MCG) devices like CPS-1 to produce energetic laboratory magneto-flows with embedded magnetic fields that can be used as a simulation tool to study flow interaction dynamic of jet flows, to demonstrate the magnetic acceleration and collimation of flows with primarily toroidal fields, and study cross field transport in turbulent accreting flows. Since plasma produced in MCG devices have magnetic topology and MHD flow regime similarity to stellar and extragalactic jets, we expect that careful investigation of these flows in the laboratory will reveal fundamental physical mechanisms influencing astrophysical flows. Discussion in the next section (sec.2) focuses on recent results describing collimation, leading flow surface interaction layers, and turbulent accretion. The primary objectives for a new three year effort would involve the development and deployment of novel electrostatic, magnetic, and visible plasma diagnostic techniques to measure plasma and flow parameters of the CPS-1 device in the flow chamber downstream of the plasma source to study, (1) mass ejection, morphology, and collimation and stability of energetic outflows, (2) the effects of external magnetization on collimation and stability, (3) the interaction of such flows with background neutral gas, the generation of visible emission in such interaction, and effect of neutral clouds on jet flow dynamics, and (4) the cross magnetic field transport of turbulent accreting flows. The applicability of existing laboratory plasma facilities to the study of stellar and extragalactic plasma should be exploited to elucidate underlying physical mechanisms that cannot be ascertained though astrophysical observation, and provide baseline to a wide variety of proposed models, MHD and otherwise. The work proposed herin represents a continued effort on a novel approach in relating laboratory experiments to

  19. Comparison of clonidine versus fentanyl as an adjuvant to intrathecal ropivacaine for major lower limb surgeries: A randomized double-blind prospective study

    Directory of Open Access Journals (Sweden)

    Anita R Chhabra

    2013-01-01

    Full Text Available Background: Ropivacaine is a newer local anesthetic, proven to have a better safety margin than bupivacaine and lignocaine. While maintaining this advantage and improving the intraoperative quality of anesthesia, the use of analgesic adjuvants has been proven to be valuable. Aim: To compare the efficacy of clonidine and fentanyl as adjuvants to intrathecal isobaric ropivacaine for major lower limb surgeries. Settings and Designs: Randomized double-blind control trial. Materials and Methods: Seventy patients were randomly divided in two groups. Ropivacaine-Clonidine group (RC received 60 mcg of clonidine with 15 mg of 0.5% isobaric ropivacaine, Ropivacaine Fentanyl group (RF received 25 mcg of fentanyl with 15 mg of 0.5% isobaric ropivacaine intrathecally. The onset and duration of sensory-motor block were recorded. The total analgesia time, sedation score, hemodynamic parameters, and side-effects were noted. Statistical Analysis: SPSS statistical package was used for statistical analysis. Paired and unpaired t-test, analysis of variance and chi-square test were used for statistical calculation. Result: The duration of sensory block in RC (329.42 ± 33.86, RF (226 ± 46.98, and motor block in RC (248.51 ± 55, RF (212.60 ± 43.52 out lasted the duration of surgery (125.61 + 64.46. In clonidine group, there was significant prolongation of sensory block (P < 0.001, motor block (P < 0.01 and the total analgesia time (P < 0.001. Hypotension and bradycardia occurred in 8.6% patients in clonidine group, whereas pruritus was experienced by 8.6% patients in fentanyl group. Conclusion: Ropivacaine when combined with clonidine or fentanyl provided adequate subarachnoid block for major surgeries, wherein clonidine has advantage over fentanyl as it increased the duration of subarachnoid block and prolonged the postoperative analgesia.

  20. Comparison of analgesic effect of intra-articular administration of levobupivacaine and clonidine versus ropivacaine and clonidine in day care knee arthroscopic surgery under spinal anesthesia

    Directory of Open Access Journals (Sweden)

    Sudeshna Senapati

    2016-01-01

    Full Text Available Introduction: Intra-articular (IA local anesthetics are often used for the management and prevention of pain after arthroscopic knee surgery. Clonidine prolongs the duration of local anesthetics. In this study, analgesic effect of intra-articular administration of levobupivacaine and clonidine was compared with ropivacaine and clonidine in knee joint arthroscopic surgery under spinal anesthesia. Method: 88 patients, aged between 15 to 55 years, ASA I and II undergoing knee arthroscopy under spinal anesthesia were assigned into two equal groups (n = 44 in a randomized double blind protocol. Patients in Group L received 10 ml of 0.50% levobupivacaine and 1 mcg/kg clonidine and Group R received 10 ml of 0.75% ropivacaine and 1 mcg/kg of clonidine through intra-articular route at the end of the procedure. In the post-operative period, pain intensity was assessed by VAS (Visual Analogue Scale Score recorded at 1 st , 5 th , 8 th , 12 th , 18 th post-operative hours. Duration of analgesia, total rescue analgesic dose in first 18 hours and any side effects were also recorded. Result: Group L experienced significantly longer duration of effective postoperative analgesia and lesser rescue analgesic compared to group R. Group R had higher mean VAS score at 5 th and 12 th post-operative hours (P < 0.05. No side effects were observed among the groups. Conclusion: Intra-articular administration of levobupivacaine and clonidine give better post-operative pain relief by increasing duration of analgesia, and decreasing need of rescue analgesic compared to intra-articular ropivacaine and clonidine.

  1. Bilateral blindness secondary to optic nerve ischemia from severe amlodipine overdose: a case report.

    Science.gov (United States)

    Kao, Raymond; Landry, Yves; Chick, Genevieve; Leung, Andrew

    2017-08-03

    Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of consciousness. We describe a case of a calcium channel blocker overdose that led to bilateral cortical blindness, a presentation that has not previously been reported. A 49-year-old white woman with known bilateral early optic atrophy presented to our hospital with hypotension and obtundation following a known ingestion of 150 mg of amlodipine. She was transferred to our intensive care unit where she was intubated, mechanically ventilated, and required maximal vasopressor support (norepinephrine 40 mcg/minute, epinephrine 40 mcg/minute, and vasopressin 2.4 units/hour) along with intravenously administered crystalloid boluses. Despite these measures, she continued to deteriorate with persistent hypotension and tachycardia, as well as anuria. Intralipid emulsion therapy was subsequently administered to which no initial response was observed. A chest X-ray revealed diffuse pulmonary edema; intravenous diuresis as well as continuous renal replacement therapy was initiated. Following the initiation of continuous renal replacement therapy, her oxygen requirements as well as urine output began to improve, and 3 days later she was liberated from mechanical ventilation. Following extubation, she complained of new onset visual impairment, specifically seeing only red-green colors, but no objects. An ophthalmologic examination revealed that this was due to bilateral optic atrophy from prolonged hypotension during the first 24 hours after the overdose. Persistent hypotension in the setting of a calcium channel blocker overdose can lead to worsening optic atrophy resulting in bilateral cortical blindness.

  2. Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury.

    Science.gov (United States)

    Statler, Kimberly D; Alexander, Henry; Vagni, Vincent; Holubkov, Richard; Dixon, C Edward; Clark, Robert S B; Jenkins, Larry; Kochanek, Patrick M

    2006-03-03

    Isoflurane improves outcome vs. fentanyl anesthesia, in experimental traumatic brain injury (TBI). We assessed the temporal profile of isoflurane neuroprotection and tested whether isoflurane confers benefit at the time of TBI. Adult, male rats were randomized to isoflurane (1%) or fentanyl (10 mcg/kg iv bolus then 50 mcg/kg/h) for 30 min pre-TBI. Anesthesia was discontinued, rats recovered to tail pinch, and TBI was delivered by controlled cortical impact. Immediately post-TBI, rats were randomized to 1 h of isoflurane, fentanyl, or no additional anesthesia, creating 6 anesthetic groups (isoflurane:isoflurane, isoflurane:fentanyl, isoflurane:none, fentanyl:isoflurane, fentanyl:fentanyl, fentanyl:none). Beam balance, beam walking, and Morris water maze (MWM) performances were assessed over post-trauma d1-20. Contusion volume and hippocampal survival were assessed on d21. Rats receiving isoflurane pre- and post-TBI exhibited better beam walking and MWM performances than rats treated with fentanyl pre- and any treatment post-TBI. All rats pretreated with isoflurane had better CA3 neuronal survival than rats receiving fentanyl pre- and post-TBI. In rats pretreated with fentanyl, post-traumatic isoflurane failed to affect function but improved CA3 neuronal survival vs. rats given fentanyl pre- and post-TBI. Post-traumatic isoflurane did not alter histopathological outcomes in rats pretreated with isoflurane. Rats receiving fentanyl pre- and post-TBI had the worst CA1 neuronal survival of all groups. Our data support isoflurane neuroprotection, even when used at the lowest feasible level before TBI (i.e., when discontinued with recovery to tail pinch immediately before injury). Investigators using isoflurane must consider its beneficial effects in the design and interpretation of experimental TBI research.

  3. A Double-Blind, Randomized Pilot Trial of Chromium Picolinate for Overweight Individuals with Binge-Eating Disorder: Effects on Glucose Regulation.

    Science.gov (United States)

    Sala, Margarita; Breithaupt, Lauren; Bulik, Cynthia M; Hamer, Robert M; La Via, Maria C; Brownley, Kimberly A

    2017-03-04

    Chromium treatment has been shown to improve glucose regulation in some populations. The purpose of this study was to evaluate whether chromium picolinate (CrPic) supplementation improves glucose regulation in overweight individuals with binge-eating disorder (BED). In this double-blinded randomized pilot trial, participants (N = 24) were randomized to high (HIGH, 1000 mcg/day, n = 8) or moderate (MOD, 600 mcg/day, n = 9) dose of CrPic or placebo (PL, n = 7) for 6 months. Participants completed an oral glucose tolerance test (OGTT) at baseline, 3 months, and 6 months. Fixed effects models were used to estimate mean change in glucose area under the curve (AUC), insulin AUC , and insulin sensitivity index (ISI). Results revealed a significant group and time interaction (p < 0.04) for glucose AUC , with glucose AUC increasing significantly in the PL group (p < 0.02) but decreasing significantly in the MOD group (p < 0.03) at 6 months. Insulin AUC increased significantly over time (main effect, p < 0.02), whereas ISI decreased significantly over time (main effect, p < 0.03). As anticipated, a moderate dose of CrPic was associated with improved glycemic control, whereas PL was associated with decreased glycemic control. It was unexpected that the improved glycemic control seen in the MOD dose group was not seen in the HIGH dose group. However, although participants randomized to the HIGH dose group did not have improved glycemic control, they had better glycemic control than participants randomized to the PL group. These findings support the need for larger trials.

  4. Transdermal nitroglycerine enhances postoperative analgesia of intrathecal neostigmine following abdominal hysterectomies

    Directory of Open Access Journals (Sweden)

    Fareed Ahmed

    2010-01-01

    Full Text Available This study was carried out to assess the effect of nitroglycerine (transdermal on intrathecal neostigmine with bupivacaine on postoperative analgesia and note the incidence of adverse effects, if any. After taking informed consent, 120 patients of ASA Grade I and II were systematically randomised into four groups of 30 each. Patients were premedicated with midazolam 0.05 mg/kg intravenously and hydration with Ringer′s lactate solution 10ml/kg preoperatively in the holding room. Group I patients received Intrathecal injection of 15 mg bupivacaine with 1ml of normal saline and transdermal placebo patch. Group II patients received Intrathecal injection of 15 mg bupivacaine with 5 mcg of neostigmine and transdermal placebo patch. Group III patients received Intrathecal injection of 15 mg bupivacaine with 1ml of normal saline with transdermal nitroglycerine patch (5 mg/24 hours. Group IV patients received Intrathecal injection of 15 mg bupivacaine with 5mcg of neostigmine and transdermal nitroglycerine patch (5 mg/24 hours, applied on a non anaesthetised area after 20 minutes. Groups were demographically similar and did not differ in intraoperative characteristics like sensory block, motor block, haemodynamic parameters and SpO 2 . The mean duration of analgesia was 202.17 minutes, 407.20 minutes, 207.53 minutes and 581.63 minutes in control group (I, neostigmine group (II, nitroglycerine group (III and nitroglycerine neostigmine group (IV respectively (P< 0.01. To conclude, our results show that transdermal nitroglycerine itself does not show any analgesic potential but it enhances the analgesic potential of intrathecal neostigmine.

  5. Low morning serum cortisol levels in children with tonsillar hypertrophy and moderate-to-severe OSA.

    Science.gov (United States)

    Malakasioti, Georgia; Alexopoulos, Emmanouel I; Varlami, Vasiliki; Chaidas, Konstantinos; Liakos, Nikolaos; Gourgoulianis, Konstantinos; Kaditis, Athanasios G

    2013-09-01

    Hypertrophic tonsillar tissue in children with obstructive sleep apnea (OSA) has enhanced expression of glucocorticoid receptors, which may reflect low endogenous cortisol levels. We have evaluated the effect of the interaction between tonsillar hypertrophy and OSA severity on morning serum cortisol levels. Children with and without snoring underwent polysomnography, tonsillar size grading, and measurement of morning serum cortisol. Seventy children (2-13 years old) were recruited: 30 with moderate-to-severe OSA (apnea-hypopnea index [AHI] > 5 episodes/h), 26 with mild OSA (AHI > 1 and ≤ 5), and 14 controls (no snoring; AHI ≤ 1). Tonsillar hypertrophy was present in 56.7%, 53.8%, and 42.9% of participants in each group, respectively. Application of a general linear model demonstrated a significant effect of the interaction between severity of OSA and tonsillar hypertrophy on cortisol levels (P = 0.04), after adjustment for obesity, gender, and age. Among children with tonsillar hypertrophy, subjects with moderate-to-severe OSA (n = 17; AHI 14.7 ± 10.6), mild OSA (n = 14; AHI 2.3 ± 1.2), and control participants (n = 6; AHI 0.7 ± 0.2) were significantly different regarding cortisol levels (P = 0.02). Subjects with moderate-to-severe OSA had lower cortisol (16.9 ± 8.7 mcg/dL) than those with mild OSA (23.3 ± 4.2; P = 0.01) and those without OSA (controls) (23.6 ± 5.3 mcg/dL; P = 0.04). In contrast, children with normal-size tonsils and moderate-to-severe OSA, mild OSA, and controls did not differ in cortisol levels. Children with moderate-to-severe obstructive sleep apnea and the phenotype of hypertrophic tonsils have reduced morning serum cortisol levels and potentially decreased glucocorticoid inhibitory effects on tonsillar growth.

  6. Assessment of iodine nutritional status in the general population in the province of Jaén.

    Science.gov (United States)

    Olmedo Carrillo, Pablo; García Fuentes, Eduardo; Gutiérrez Alcántara, Carmen; Serrano Quero, Manuel; Moreno Martínez, Macarena; Ureña Fernández, Tomás; Santiago Fernández, Piedad

    2015-10-01

    Iodine deficiency affecting both pregnant women and schoolchildren has been reported in Jaén. Iodine deficiency is one of the leading causes of thyroid dysfunction and goiter, and adequate iodine prophylaxis with iodized salt, milk, and dairy products, or iodine supplementation have been shown to significantly improve iodine status in pregnancy. The purpose of this study was to assess iodine nutritional status in the general population of a iodine-deficient area with no previous institutional campaigns of iodine prophylaxis. A descriptive, cross-sectional study. Urinary iodine levels were measured in subjects from the Jaén healthcare district. The data were stratified by sex and age groups, and a survey was conducted on iodized salt consumption. Median and mean urinary iodine levels were 110.59 mcg/L and 130.11 mcg/L respectively. Urinary iodine levels were significantly higher in schoolchildren as compared to other age groups (161.52μg/L vs 109.33μg/L in subjects older than 65 years). Forty-three percent of the population had urinary iodine levels less than 100μg/L, and 68% of women of childbearing age had levels less than 150μg/L. Iodine nutritional status appears to be adequate, but the proportion of the population with urinary iodine levels less than 100μg/L is still very high, and iodized salt consumption is much less common than recommended by the WHO. Copyright © 2015 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

  7. CPSS: a computational platform for the analysis of small RNA deep sequencing data.

    Science.gov (United States)

    Zhang, Yuanwei; Xu, Bo; Yang, Yifan; Ban, Rongjun; Zhang, Huan; Jiang, Xiaohua; Cooke, Howard J; Xue, Yu; Shi, Qinghua

    2012-07-15

    Next generation sequencing (NGS) techniques have been widely used to document the small ribonucleic acids (RNAs) implicated in a variety of biological, physiological and pathological processes. An integrated computational tool is needed for handling and analysing the enormous datasets from small RNA deep sequencing approach. Herein, we present a novel web server, CPSS (a computational platform for the analysis of small RNA deep sequencing data), designed to completely annotate and functionally analyse microRNAs (miRNAs) from NGS data on one platform with a single data submission. Small RNA NGS data can be submitted to this server with analysis results being returned in two parts: (i) annotation analysis, which provides the most comprehensive analysis for small RNA transcriptome, including length distribution and genome mapping of sequencing reads, small RNA quantification, prediction of novel miRNAs, identification of differentially expressed miRNAs, piwi-interacting RNAs and other non-coding small RNAs between paired samples and detection of miRNA editing and modifications and (ii) functional analysis, including prediction of miRNA targeted genes by multiple tools, enrichment of gene ontology terms, signalling pathway involvement and protein-protein interaction analysis for the predicted genes. CPSS, a ready-to-use web server that integrates most functions of currently available bioinformatics tools, provides all the information wanted by the majority of users from small RNA deep sequencing datasets. CPSS is implemented in PHP/PERL+MySQL+R and can be freely accessed at http://mcg.ustc.edu.cn/db/cpss/index.html or http://mcg.ustc.edu.cn/sdap1/cpss/index.html.

  8. Adiponectin changes in relation to the macronutrient composition of a weight-loss diet.

    Science.gov (United States)

    Summer, Suzanne S; Brehm, Bonnie J; Benoit, Stephen C; D'Alessio, David A

    2011-11-01

    Adiponectin is an adipose-derived protein with beneficial metabolic effects. Low adiponectin is associated with obesity and related diseases. Significant weight loss increases adiponectin, reducing disease risk. This study compared the effects of two weight-loss diets with different macronutrient compositions on adiponectin. Eighty-one obese women in two cohorts were randomized to a low-fat (LF) or a low-carbohydrate (LC) diet. All subjects underwent equivalent weight-loss intervention, with weight and other measures assessed at baseline and after 6 (cohort I) or 4 (cohort II) months. Body fat was measured by dual energy X-ray absorptiometry. Adiponectin was measured by radioimmunoassay. Diet intake was assessed using 24-h recalls and 3-day diet records. Data were analyzed via t-tests and repeated-measures factorial ANOVA using time, diet, and replicate (cohort I vs. cohort II) as factors. Age, weight, body fat, BMI, adiponectin, and diet were similar at baseline. Following intervention, macronutrient composition of the diet was vastly different between the groups, reflecting the assigned diet. Both groups lost weight and body fat (P vs. -4.97 kg weight, P vs. -2.62 kg fat, P < 0.001). Adiponectin increased in the LC (+1.92 mcg/ml, P < 0.01), but not the LF (+0.86 mcg/ml, P = 0.81), group. There was no correlation between weight loss and increase in adiponectin. These results confirm that diet-induced loss of weight and body fat is associated with increased adiponectin concentrations. This effect is evident with weight loss of 10% or more, and may be greater with LC diets.

  9. The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy.

    Science.gov (United States)

    Ozdemir, Mehmet A; Yilmaz, Kenan; Abdulrezzak, Ummuhan; Muhtaroglu, Sebahattin; Patiroglu, Turkan; Karakukcu, Musa; Unal, Ekrem

    2013-11-01

    Thalassemic osteopathy (TOSP) has emerged as a topic of interest, as the optimized transfusion regimens and iron chelations has markedly improved the survival of the patients suffering from thalassemia major (TM) and increased the life expectancy. The aim of this prospective monocentric pilot study was to investigate the effects of a dietary supplement with vitamin K2 (50 mcg menaquinone-7) and vitamin D (5 mcg calcitriol) on the patients with TOSP. Twenty children (12 girls, 8 boys; age varied from 3 to 18 y) with β TM, who underwent regular blood transfusion and iron chelation therapy, were enrolled in this study and investigated at the initial, sixth, and 12th month of the treatment. We detected a significant improvement in the bone mineral density and Z-score at the lumbar spine area of the patients at the sixth and 12th month of the treatment, especially in the prepubertal group. We also found a decrease in the ratio of undercarboxylated osteocalcin to carboxylated osteocalcin, however, this was not found to be significant. Although the natural course of TOSP is worsening or at least stabilizing, our pilot study demonstrated that vitamin K2 and calcitriol combination clearly has a positive effect on the bone mineral density of the children with TM during a 1-year period. Supplementation of menaquinone-7 instead of drugs is an augmented physiological intake and seems a beneficial alternative for the treatment of TOSP. Further studies on a large number of participants are necessary to highlight the effect of vitamin K2 on TOSP.

  10. Moderate sedation for MRI in young children with autism

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Allison Kinder [Duke University Medical Center, Division of Pediatric Anesthesia, Durham (United States); Hazlett, Heather Cody; Garrett, Nancy T [University of North Carolina School of Medicine, Department of Psychiatry, Chapel Hill, NC (United States); Wilkerson, Christy [Duke University Medical Center, Department of Radiology, Durham, NC (United States); Piven, Joseph [University of North Carolina School of Medicine, Departments of Psychiatry and Pediatrics, Chapel Hill, NC (United States)

    2005-09-01

    Autism is a pervasive neurodevelopmental disorder. Because of the deficits associated with the condition, sedation of children with autism has been considered more challenging than sedation of other children. To test this hypothesis, we compared children with autism against clinical controls to determine differences in requirements for moderate sedation for MRI. Children ages 18-36 months with autism (group 1, n = 41) and children with no autistic behavior (group 2, n = 42) were sedated with a combination of pentobarbital and fentanyl per sedation service protocol. The sedation nurse was consistent for all patients, and all were sedated to achieve a Modified Ramsay Score of 4. Demographics and doses of sedatives were recorded and compared. There were no sedation failures in either group. Children in group 1 (autism) were significantly older than group 2 (32.02{+-}3.6 months vs 28.16{+-}6.7 months) and weighed significantly more (14.87{+-}2.1 kg vs 13.42{+-}2.2 kg). When compared on a per-kilogram basis, however, group 1 had a significantly lower fentanyl requirement than group 2 (1.25{+-}0.55 mcg/kg vs 1.57{+-}0.81 mcg/kg), but no significant difference was found in pentobarbital dosing between groups 1 and 2, respectively (4.92{+-}0.92 mg/kg vs 5.21{+-}1.6 mg/kg). Autistic children in this age range are not more difficult to sedate and do not require higher doses of sedative agents for noninvasive imaging studies. (orig.)

  11. Moderate sedation for MRI in young children with autism

    International Nuclear Information System (INIS)

    Ross, Allison Kinder; Hazlett, Heather Cody; Garrett, Nancy T.; Wilkerson, Christy; Piven, Joseph

    2005-01-01

    Autism is a pervasive neurodevelopmental disorder. Because of the deficits associated with the condition, sedation of children with autism has been considered more challenging than sedation of other children. To test this hypothesis, we compared children with autism against clinical controls to determine differences in requirements for moderate sedation for MRI. Children ages 18-36 months with autism (group 1, n = 41) and children with no autistic behavior (group 2, n = 42) were sedated with a combination of pentobarbital and fentanyl per sedation service protocol. The sedation nurse was consistent for all patients, and all were sedated to achieve a Modified Ramsay Score of 4. Demographics and doses of sedatives were recorded and compared. There were no sedation failures in either group. Children in group 1 (autism) were significantly older than group 2 (32.02±3.6 months vs 28.16±6.7 months) and weighed significantly more (14.87±2.1 kg vs 13.42±2.2 kg). When compared on a per-kilogram basis, however, group 1 had a significantly lower fentanyl requirement than group 2 (1.25±0.55 mcg/kg vs 1.57±0.81 mcg/kg), but no significant difference was found in pentobarbital dosing between groups 1 and 2, respectively (4.92±0.92 mg/kg vs 5.21±1.6 mg/kg). Autistic children in this age range are not more difficult to sedate and do not require higher doses of sedative agents for noninvasive imaging studies. (orig.)

  12. Efficacy and safety of budesonide/formeterol combination therapy in asthma patients.

    Science.gov (United States)

    Jakopović, Marko; Pavicić, Fadila; Redzepi, Gzim; Plestina, Sanja; Janković, Mateja; Franić, Zrinka; Samija, Mirko; Samarzija, Miroslav

    2009-06-01

    Budesonide/formoterol as single inhaler was developed for treating asthma patients who are not adequately controlled on glucocorticoides alone. The aim of this study was to evaluate efficacy, safety and patient/physician satisfaction of budesonide/formoterol therapy.Total of 268 asthma patients (120 men, mean age 38.8 +/- 37.2 years, and 148 women, mean age 42.2 +/- 32 years) were included in the study. All patients received budesonide/formoterol bid (640 mcg of budesonide and 18 mcg of formoterol daily) during run-in period for three weeks. Patients were followed during 14 weeks at 5 visits. At each visit lung function (FEV1 and PEF) was measured,presence of side affects was recorded and questionnaire was given to patients and physicians to estimate the level of satisfaction with budesonide/formoterol therapy (1 very unsatisfied to 5 very satisfied). Significant improvement was noticed in FEV1, from 76.25% of predicted value to 86.94% (p < 0.01); and in PEF from 380.84 L/min to 442.29 L/min (p < 0.01) in all patients. At the end of the study patients' satisfaction with budesonide/formeterol therapy was significantly improved comparing with satisfaction with previously taken therapy, in average grade, from 2.94 to 4.56 (p < 0.01), and similar results were noticed with physicians' satisfaction, from 2.60 to 4.41 (p < 0.01). Budesonide/formoterol in single inhaler, significantly improved lung function in patients with asthma.

  13. Impact of open manganese mines on the health of children dwelling in the surrounding area

    Science.gov (United States)

    Duka, Ykateryna D.; Ilchenko, Svetlana I.; Kharytonov, Mykola M.; Vasylyeva, Tetyana L.

    2011-01-01

    Introduction: Chronic manganese (Mn) exposure is a health hazard associated with the mining and processing of Mn ores. Children living in an area with increased environmental exposure to Mn may have symptoms of chronic toxicity that are different from adults who experience occupational exposure. The aim of the study was to compare health outcomes in a pediatric population living near open Mn mines with a group of children from a reference area and then to develop and implement preventive/rehabilitation measures to protect the children in the mining region. Methods: After environmental assessment, a group of 683 children living in a Mn-rich region of Ukraine were screened by clinical evaluation, detection of sIgA (37 children), micronucleus analysis (56 children), and hair Mn content (166 children). Results: Impaired growth and rickets-like skeletal deformities were observed in 33% of the children. This was a significantly higher percentage than in children in the reference region (15%). The children from the Mn-mining region also had increased salivary levels of immunoglobulin A (104.4±14.2 mcg/ml vs. 49.7±6.1 mcg/ml among the controls (p<0.05), increased serum alpha 1 proteinase inhibitor levels (4.93±0.21 g/l compared with 2.91±0.22 g/l for controls; p<0.001) and greater numbers of micronuclei in the mucous cells of the oral cavity (0.070±0.008 vs. 0.012±0.009, p<0.001). Conclusions: These findings indicate the deleterious health consequences of living in a Mn-mining area. Medical rehabilitation programs were conducted and produced positive results, but further validation of their effectiveness is required. The study provided background information to formulate evidence-based decisions about public health in a region of high Mn exposure. PMID:24149028

  14. Microbial Communities and Organic Matter Composition in Surface and Subsurface Sediments of the Helgoland Mud Area, North Sea

    Science.gov (United States)

    Oni, Oluwatobi E.; Schmidt, Frauke; Miyatake, Tetsuro; Kasten, Sabine; Witt, Matthias; Hinrichs, Kai-Uwe; Friedrich, Michael W.

    2015-01-01

    The role of microorganisms in the cycling of sedimentary organic carbon is a crucial one. To better understand relationships between molecular composition of a potentially bioavailable fraction of organic matter and microbial populations, bacterial and archaeal communities were characterized using pyrosequencing-based 16S rRNA gene analysis in surface (top 30 cm) and subsurface/deeper sediments (30–530 cm) of the Helgoland mud area, North Sea. Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS) was used to characterize a potentially bioavailable organic matter fraction (hot-water extractable organic matter, WE-OM). Algal polymer-associated microbial populations such as members of the Gammaproteobacteria, Bacteroidetes, and Verrucomicrobia were dominant in surface sediments while members of the Chloroflexi (Dehalococcoidales and candidate order GIF9) and Miscellaneous Crenarchaeota Groups (MCG), both of which are linked to degradation of more recalcitrant, aromatic compounds and detrital proteins, were dominant in subsurface sediments. Microbial populations dominant in subsurface sediments (Chloroflexi, members of MCG, and Thermoplasmata) showed strong correlations to total organic carbon (TOC) content. Changes of WE-OM with sediment depth reveal molecular transformations from oxygen-rich [high oxygen to carbon (O/C), low hydrogen to carbon (H/C) ratios] aromatic compounds and highly unsaturated compounds toward compounds with lower O/C and higher H/C ratios. The observed molecular changes were most pronounced in organic compounds containing only CHO atoms. Our data thus, highlights classes of sedimentary organic compounds that may serve as microbial energy sources in methanic marine subsurface environments. PMID:26635758

  15. The effects of epidural bupivacaine on ischemia/reperfusion-induced liver injury.

    Science.gov (United States)

    Sarikus, Z; Bedirli, N; Yilmaz, G; Bagriacik, U; Bozkirli, F

    2016-01-01

    Several animal studies showed beneficial effects of thoracic epidural anesthesia (TEA) in hippocampal, mesenteric and myocardial IR injury (2-4). In this study, we investigated the effects of epidural bupivacaine on hepatic ischemia reperfusion injury in a rat model. Eighteen rats were randomly divided into three groups each containing 6 animals. The rats in Group C had sham laparotomy. The rats in the Group S were subjected to liver IR through laparotomy and 20 mcg/kg/h 0.9% NaCl was administered to these rats via an epidural catheter. The rats in the Group B were subjected to liver IR and were given 20 mcg/kg/h bupivacaine via an epidural catheter. Liver tissue was harvested for MDA analysis, apoptosis and histopathological examination after 60 minutes of ischemia followed by 360 minutes of reperfusion. Blood samples were also collected for TNF-α, IL-1β, AST and ALT analysis. The AST and ALT levels were higher in ischemia and reperfusion group, which received only normal saline via the thoracic epidural catheter, compared to the sham group. In the ischemia reperfusion group, which received bupivacaine via the epidural catheter, IL-1 levels were significantly higher than in the other groups. TNF-α levels were higher in the Groups S and B compared to the sham group. Bupivacaine administration induced apoptosis in all animals. These results showed that thoracic epidural bupivacaine was not a suitable agent for preventing inflammatory response and lipid peroxidation in experimental hepatic IR injury in rats. Moreover, epidural bupivacaine triggered apoptosis in hepatocytes. Further research is needed as there are no studies in literature investigate the effects of epidural bupivacaine on hepatic ischemia reperfusion injury (Tab. 3, Fig. 3, Ref. 34).

  16. Urban expansion simulation and the spatio-temporal changes of ecosystem services, a case study in Atlanta Metropolitan area, USA.

    Science.gov (United States)

    Sun, Xiao; Crittenden, John C; Li, Feng; Lu, Zhongming; Dou, Xiaolin

    2018-05-01

    Urban expansion can lead to land use changes and, hence, threatens the ecosystems. Understanding the effects of urbanization on ecosystem services (ESs) can provide scientific guidance for land use planning and the protection of ESs. We established a framework to assess the spatial distributions of ESs based on land use changes in the Atlanta Metropolitan area (AMA) from 1985 to 2012. A new comprehensive ecosystem service (CES) index was developed to reflect the comprehensive level of ESs. Associated with the influential factors, we simulated the business as usual scenario in 2030. Four alternative scenarios, including more compact growth (MCG), riparian vegetation buffer (RVB), soil conservation (SC), and combined development (CD) scenarios were developed to explore the optimal land use strategies which can enhance the ESs. The results showed that forest and wetland had the greatest decreases, while low and high intensity built-up lands had the greatest increases. The values of CES and most of ESs decreased significantly due to the sprawling expansion of built-up land. The scenario analysis revealed that the CD scenario performs best in CES value, while it performs the worst in food supply. Compared with the RVB and SC scenarios, MCG scenario is a more optimal land use strategy to enhance the ESs without at the expense of food supply. To integrate multiple ESs into land use planning and decision making, corresponding land management policies and ecological engineering measures should be implemented to enhance: (1) the water yield and water purification in urban core counties, (2) the carbon storage, habitat quality, and recreational opportunity in counties around the core area, and (3) the soil conservation and food supply in surrounding suburban counties. The land use strategies and ecological engineering measures in this study can provide references for enhancing the ESs in the AMA and other metropolitan areas. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. New radioimmunoassay for follicle-stimulating hormone in macaques: ovulatory menstrual cycles. [/sup 125/I tracer technique

    Energy Technology Data Exchange (ETDEWEB)

    Hodgen, G.D.; Wilks, J.W.; Vaitukaitis, J.L.; Chen, H.C.; Papkoff, H.; Ross, G.

    1976-07-01

    A sensitive and specific radioimmunoassay system for macaque follicle-stimulating hormone (mFSH) was developed utilizing an antiserum (H-31) prepared in a rabbit against purified ovine FSH as the immunogen. Sera from castrated female, adult male, and juvenile rhesus monkeys, as well as urinary extracts from castrated rhesus and bonnet monkeys, were used to demonstrate parallelism with a standard of partially purified monkey pituitary gonadotropins (LER-M-907-D). An extract of baboon pituitary tissue also showed parallelism with the reference standard. A highly purified pituitary extract (WP-X-105-28), containing approximately 75 percent macaque luteinizing hormone (mLH) and 1 percent mFSH, was used to demonstrate the specificity of this mFSH assay system. Sera and urinary extracts obtained from hypophysectomized monkeys did not show cross-reactivity in the assay. Macaque chorionic gonadotropin (mCG) did not produce an inhibition curve in the assay, as determined from serum samples and urinary extracts collected from pregnant monkeys at the time of peak mCG secretion. Serum concentrations of mFSH were suppressed in ovariectomized monkeys by the administration of ethinyl estradiol for 3 days, but returned to near pretreatment values by 96 h after the last estradiol administration. The determination of serum mFSH concentrations in daily blood samples obtained from 20 rhesus monkeys throughout ovulatory menstrual cycles revealed a pattern similar to that previously reported for the rhesus monkey and the woman. The peak value of serum mFSH during the menstrual cycle coincided with the midcycle surge of mLH in each case. The gonadotropin peaks were preceded by increasing serum concentrations of estradiol and followed by rises in the serum concentrations of progesterone.

  18. Neutron activation analysis of small particles brought back from the asteroid Itokawa by the space probe Hayabusa

    International Nuclear Information System (INIS)

    Ebihara, Mitsuru

    2013-01-01

    The probe in the title launched in May 2003, landed on the asteroid 25143 (Itokawa) to collect the surface material, and returned to the desert of Australia in June 2010. The material carried in Japan Aerospace Exploration Agency (JAXA) was found to be >1,500 particles of extraterrestrial origin. This paper reports the results of activation analysis of a part of particles for the purpose of characterizing the elemental composition. The size of particles was mostly <100 mc-m and the mass, several 10s mc-g. The experiment was performed preliminarily on Kilabo meteorite using Kyoto University Research Reactor (KURR) as a neutron source, and then on 1 Itokawa particle named RA-QD02-0049, which was activated for 19 hr. The cooled particle was found to be split mainly in 2 parts (0049-1 and -2), which were subjected to analysis of gamma ray with Ge semiconductor detector in the KURR Institute and Kanazawa University. Analysis revealed that the 2 particles contained 8 elements of Na, Sc, Cr, Fe, Co, Ni, Zn and Ir, which were then quantitated with similarly neutron irradiated Allende meteorite, basalt JB-1 and highly purified Fe, and with previous findings by scanning electron microscope with energy dispersive X-ray spectrometer (SEM-EDX) showing the Itokawa particle was an olivine. Finally, 0049-1 and -2 were found to be of mass of 1.6 and 1.5 mc-g, respectively, based on which the calculated contents of the 8 elements revealed that they were homogeneously existed in the Itokawa particle. Comparison of elemental composition of the particle with those of various intra- and extra-terrestrial rocks and meteorites suggested that Itokawa had a feature of elements aggregated at the early stage after formation of the solar system 4.5 billion years ago. (T.T.)

  19. HYPOPHOSPHATEMIC RICKETS: CASE REPORT.

    Science.gov (United States)

    Maia, Marta Liliane de Almeida; Abreu, Ana Lucia Santos; Nogueira, Paulo Cesar Koch; Val, Maria Luiza Dautro Moreira do; Carvalhaes, João Tomas de Abreu; Andrade, Maria Cristina de

    2018-03-29

    Early diagnosis and immediate treatment of hypophosphatemic rickets is of utmost importance as it may prevent subsequent sequelae. This report aims at warning pediatricians to consider the presence of the disease. Description of the metabolic profile, creatinine clearance, nutritional status, weight and body structure of a patient who presented the clinical-laboratorial characteristics of hypophosphatemic rickets and was followed in an outpatient clinic for tubulopathies over the period of 12 months. The patient had been bedridden for some time, was dependent on mechanical ventilation and presented an altered metabolic bone condition. Treatment was phosphate (initial: 65 mg/kg/day and final: 24,2 mg/kg/day), calcium (initial: 127 mg/kg/day, final: 48,4 mg/kg/day) and calcitriol (initial: 0.06 mcg/kg/day, final: 0.03 mcg/kg/day). The patient improved, evolving into spontaneous breathing and walking unaided. Laboratory results: calcium (mg/dL) initial 7.1, final 10.1; phosphate (mg/dL) initial 1.7 final 3.2; magnesium (mg/dL) initial 1.5 final 2.1, parathyroid hormone (pg/l) initial 85.8, final 52.7, alkaline phosphatase (UI/l) initial 12660, final 938; there was also improvement in weight/structural development (Z score: H/A initial: -6.05, final -3.64; W/A: initial -2.92, final -1.57) with presence of transitory gallstones. Creatinine clearance (mL/min/1.73m2bsa) was constant. The medication improved his laboratory results and nutritional status, but the patient did not return for two years for follow-up and, during this period, his condition has noticeably deteriorated. Early diagnosis and follow-up are essential in dealing with this pathology.

  20. Characterization of thrombosis in patients with Proteus syndrome.

    Science.gov (United States)

    Keppler-Noreuil, Kim M; Lozier, Jay N; Sapp, Julie C; Biesecker, Leslie G

    2017-09-01

    Patients with overgrowth and complex vascular malformation syndromes, including Proteus syndrome have an increased risk of thromboembolism. Proteus syndrome is a mosaic, progressive overgrowth disorder involving vasculature, skin, and skeleton, and caused by a somatic activating mutation in AKT1. We conducted a comprehensive review of the medical histories and hematologic evaluations of 57 patients with Proteus syndrome to identify potential risk factors for thrombosis. We found that six of ten patients, who were deceased, died secondary to deep venous thrombosis and/or pulmonary embolism. Of the remaining 47 living patients, six had thromboembolic events that all occurred postoperatively and in an affected limb. Eleven of 21 patients had an abnormal hypercoagulable panel including Factor V Leiden heterozygotes, antithrombin III deficiency, positive lupus anticoagulant, or Protein C or S deficiencies. We observed that eight of 17 patients had an abnormal D-dimer level >0.5 mcg/dl, but deep venous thromboses occurred in only four of those with D-dimer >1.0 mcg/dl. We conclude that the predisposition to thrombosis is likely to be multifaceted with risk factors including vascular malformations, immobility, surgery, additional prothrombotic factors, and possible pathophysiologic effects of the somatic AKT1 mutation on platelet function or the vascular endothelium. The D-dimer test is useful as a screen for thromboembolism, although the screening threshold may need to be adjusted for patients with this disorder. We propose developing a registry to collect D-dimer and outcome data to facilitate adjustment of the D-dimer threshold for Proteus syndrome and related disorders, including PIK3CA-Related Overgrowth Spectrum. © 2017 Wiley Periodicals, Inc.

  1. Comparison of analgesic efficacy of levobupivacaine, levobupivacaine and clonidine, and levobupivacaine and dexmedetomidine in wound infiltration technique for abdominal surgeries: A prospective randomized controlled study

    Directory of Open Access Journals (Sweden)

    B Jyothi

    2017-01-01

    Full Text Available Background: This study was designed to evaluate the postoperative analgesic efficacy of levobupivacaine (L alone and its combination with clonidine (C or dexmedetomidine (D in wound infiltration technique for abdominal surgeries. Materials and Methods: After ethical committee approval, a double-blind randomized controlled study was conducted on 90 patients (power of study 80%, physical status American Society of Anesthesiologists Grade I and II, aged 18–60 years scheduled for abdominal surgeries over 1 year duration. A standard general anesthetic technique was used. Patients were randomly allocated into three groups, by computer-generated random number table. Patients received wound infiltration during wound closure. Group L received 29 ml of 0.25% levobupivacaine plus 1 ml 0.9% normal saline, Group LC received 29 ml of 0.25% levobupivacaine with 1 ml (3 mcg/kg clonidine, and Group LD received 29 ml of 0.25% levobupivacaine with 1 ml (2 mcg/kg dexmedetomidine. Postoperative rescue analgesia was provided with injection tramadol. Statistical analysis for duration of analgesia was determined by one-way analysis of variance and side effects by Chi-square test. Results: The total duration of analgesia in LD group was 23.4 h, when compared to LC group 20.9 h and L group 11.65 h (P = 0.0001 with excellent to good quality of analgesia in adjuvant group (P < 0.001 and incidence of minimal side effects such as sedation, nausea, and vomiting. Conclusion: Clonidine and dexmedetomidine were the effective adjuvants to levobupivacaine for single shot wound infiltration analgesic technique; however, dexmedetomidine was found to be superior to clonidine.

  2. Lavage with allicin in combination with vancomycin inhibits biofilm formation by Staphylococcus epidermidis in a rabbit model of prosthetic joint infection.

    Directory of Open Access Journals (Sweden)

    Haohan Zhai

    Full Text Available BACKGROUND AND AIM: The present anti-infection strategy for prosthetic joint infections (PJI includes the use of antibiotics and surgical treatments, but the bacterial eradication rates are still low. One of the major challenges is the formation of biofilm causing poor bacterial eradication. Recently it has been reported that allicin (diallyl thiosulphinate, an antibacterial principle of garlic, can inhibit bacteria adherence and prevent biofilm formation in vitro. However, whether allicin could inhibit biofilm formation in vivo is unknown. The aim of this study was to investigate the effects of allicin on biofilm formation, and whether allicin could potentiate the bactericidal effect of vancomycin in a rabbit PJI model. METHODS: A sterile stainless-steel screw with a sterile ultra-high molecular weight polyethylene washer was inserted into the lateral femoral condyle of the right hind knee joint of rabbit, and 1 mL inoculum containing 104 colony-forming units of Staphylococcus epidermidis was inoculated into the knee joint (n = 32. Fourteen days later, rabbits randomly received one of the following 4 treatments using continuous lavages: normal saline, vancomycin (20 mcg/mL, allicin (4 mg/L, or allicin (4 mg/L plus vancomycin (20 mcg/mL. Three days later, the washer surface biofilm formation was examined by scanning electron microscopy (SEM. The bacterial counts within the biofilm of implanted screws were determined by bacterial culture. RESULTS: The lowest number of viable bacterial counts of Staphylococcus epidermidis recovered from the biofilm was in the rabbits treated with allicin plus vancomycin (P<0.01 vs. all other groups. The biofilm formation was significantly reduced or undetectable by SEM in rabbits receiving allicin or allicin plus vancomycin. CONCLUSION: Intra-articular allicincan inhibit biofilm formation and enhance the bactericidal effect of vancomycin on implant surface in vivo. Allicin in combination with vancomycin may be

  3. Vinorelbine-Cyclophosphamide compared to cyclophosphamide in peripheral blood stem cell mobilization for multiple myeloma.

    Science.gov (United States)

    de Mel, Sanjay; Chen, Yunxin; Lin, Adeline; Soh, Teck Guan; Ooi, Melissa; Yap, Eng Soo; Donato, Lara Kristina Sioco; Halim, Nurul Aidah Abdul; Mah, Joanna; Lim, Karen; Poon, Li Mei; Tan, Belinda; Yelly; Lim, Hui Li; Koh, Liang Piu; Tai, Bee Choo; Chen, Zhaojin; Chng, Wee Joo; Gopalakrishnan, Satish Kumar; Tan, Lip Kun

    2018-04-23

    High dose Cyclophosphamide (Cy) and Vinorelbine Cyclophosphamide (Vino-Cy) are stem cell (SC) mobilisation options for patients with multiple myeloma (MM). We present a comparison of mobilisation outcomes using these regimens. Vino-Cy patients received Vinorelbine 25 mg/m 2 on day 1, cyclophosphamide 1500 mg/m 2 on day 2, and pegylated GCSF on day 4 or GCSF 10 mcg/kg/day from day 4 onwards. Cy patients were given cyclophosphamide 4000 mg/m 2 on day 1 and GCSF10 mcg/kg/day from day 5 onwards. The target CD34 + SC collection was 5 × 10 6  per kg/BW. 149 patients were included. SC collection was lower in the Vino-Cy group (8.20 × 10 6 /Kg BW) compared to the Cy group (11.43 × 10 6 /Kg BW), with adjusted geometric mean ratio of 0.59 (95% CI 0.41 to 0.86, p = 0.006). Time taken to achieve an adequate PB SC count was shorter for Vino-Cy (9 ± 1 day compared to 12 ± 2 days for Cy, adjusted absolute mean difference -3.95, 95% CI -4.85 to -3.06, P < .001). Mobilisation related toxicities (in particular, neutropaenic fever) were greater for Cy. Vino-Cy is a potential alternative to Cy given the need for effective mobilisation protocols with acceptable toxicity. Copyright © 2018 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved.

  4. The Use of Fecal Calprotectin Levels in the Fontan population.

    Science.gov (United States)

    Miranda, Carlos; Taqatqa, Anas; Chapa-Rodriguez, Adrian; Holton, Jacob P; Awad, Sawsan M

    2018-03-01

    The Fontan procedure was first performed in the seventies as a palliation for patients with single ventricle physiology. A feared complication after a Fontan procedure is the development of protein losing enteropathy (PLE). Systemic inflammation has a negative effect on the intestinal barrier integrity, which has supported the use of steroids in this setting. To the best of our knowledge there are no studies linking intestinal inflammation in patients with PLE after Fontan. The objective of this study was to identify the presence of intestinal inflammation measured by FC in patients with PLE after a Fontan procedure. A cross-sectional analysis was performed examining 23 stool samples from 23 Fontan patients for both Fecal alpha-1-antitrypsin (FA1AT) and FC with and without PLE. The median FC was 21 mcg/gm of stool (IQR: 15.7-241 mcg/gm of stool), and the median FA1AT was 40 mg/dL (IQR: 30-220 mg/dL). The median FC and FA1AT were significantly higher in the PLE group than in the Non-PLE group (p = 0.002 and p PLE, which correlated with the elevated levels of FA1AT. Inversely, levels of FC in Fontan patients without suspected PLE were within the normal range. To our knowledge, this is the first study to demonstrate intestinal inflammation using FC in the setting of PLE within this cohort, and may prove to be useful as a diagnostic tool in its treatment.

  5. Evaluation of adverse events noted in children receiving continuous infusions of dexmedetomidine in the intensive care unit.

    Science.gov (United States)

    Honey, Brooke L; Harrison, Donald L; Gormley, Andrew K; Johnson, Peter N

    2010-01-01

    Dexmedetomidine is an α(2)-adrenergic receptor agonist with sedative and analgesic effects in mechanically ventilated adults and children. Safety and efficacy data are limited in children. The purpose of this study is to retrospectively identify the incidence and types of adverse events noted in children receiving continuous infusions of dexmedetomidine and evaluate potential risk factors for adverse events. Between July 1, 2006, and July 31, 2007, data were collected on all children (events. The primary endpoint was the total number of adverse events noted, including: transient hypertension, hypotension, neurological manifestations, apnea, and bradycardia. Secondary endpoints included categorization of each type of adverse event and an assessment of risk factors. A logistic regression model was used to assess the relationship of adverse events with independent variables including length of ICU stay, cumulative dose, peak infusion rate, duration of therapy, PRISM III score, and bolus dose. Thirty-six patients received dexmedetomidine representing 41 infusions. The median age was 16 months (range, 0.1-204 months) and median PRISM III score was 2 (range, 0-18). Eighteen (43.9%) patients received a bolus dose of dexmedetomidine. The median cumulative dose (mcg/kg) and peak dose (mcg/kg/hr) were 8.5 (range, 2.2-193.7) and 0.5 (range, 0.2-0.7), respectively. Dexmedetomidine was continued for a median of 20 (range, 3-263) hours. Six (14.6%) patients were slowly tapered off the continuous infusions. Twenty-one adverse events were noted in 17 patients, including 4 neurologic manifestations. Fourteen patients required interventions for adverse events. ICU length of stay was the only independent risk factor (p=0.036) for development of adverse events. Several potential adverse events were noted with dexmedetomidine continuous infusions including possible neurological manifestations. Further studies are needed looking at adverse events associated with dexmedetomidine use in

  6. Genetic Diversity of Foxtail Millet (Setaria italica L.) From Main Asian Habitats Based on the NRDNA ITS Region

    International Nuclear Information System (INIS)

    Sun, Y. L.; Zheng, S. L.; Lee, J. K.

    2016-01-01

    Foxtail millet (Setaria italica (L.) P. Beauv.) is a crop of historical importance in some Asian and European countries. In this study, we selected the internal transcribed spacer (ITS) region of nuclear ribosomal DNA (nrDNA) as the DNA marker to analyze genetic diversity and relationships of 20 foxtail millet strains collected from three representative Asian countries, including China, Korea, and Pakistan. Due to the length limitation of the nrDNA ITS region, 17 typical variable nucleotide sites were only found, of which 4 sites belonged to insertion, 3 sites deletion, and 10 sites substitution. According to the result of sequence alignment, strains were grouped clearly with the relevant of collected geographical region. Based on the sequence similarity and nucleotide variation, one Main China Group (MCG) and one Main Korea Group (MKG) occurred, and the strains from Pakistan were found to be close to MKG, considered to be originally transmitted from Korea and spread to Pakistan. Certain genetic diversity between strains from Pakistan and Korea were recognized as long-time environment evolution and adaptation. Among strains from Korea, K2, K3, K4, and K5 showed nearer phylogenetic relationship to MCG, considered as Chinese populations. All strains from China showed relatively near phylogenetic relationship with each other, supporting the statement that China is one of origin areas. The result also suggested that there was no introduced strain found in the Chinese strains investigated in this study. This work would provide more sequence sources and help clearer strain distinguishing, genetic diversity and phylogenetic relationship of foxtail millet. (author)

  7. Mobilization of hematopoietic progenitor cells with granulocyte colony stimulating factors for autologous transplant in hematologic malignancies: a single center experience

    Science.gov (United States)

    Gabús, Raul; Borelli, Gabriel; Ferrando, Martín; Bódega, Enrique; Citrín, Estela; Jiménez, Constanza Olivera; Álvarez, Ramón

    2011-01-01

    Background In 2006 the Hematology Service of Hospital Maciel published its experience with peripheral blood progenitor cell harvesting for autologous stem cell transplantation using Filgen JP (Clausen Filgrastim). After mobilization with a mean filgrastim dose of 78 mcg/Kg, 4.7 x 106 CD34+ cells/Kg were obtained by apheresis. Age above 50, multiple myeloma as underlying disease and a malignancy that was not in remission were identified as frequent characteristics among patients showing complex mobilization. Objective The aim of this study was to compare stem cell mobilization using different brands of filgrastim. Methods One hundred and fifty-seven mobilizations performed between 1997 and 2006 were analyzed. This retrospective analysis comparative two groups of patients: those mobilized with different brands of filgrastim (Group A) and those who received Filgen JP (Clausen Filgrastim) as mobilizing agent (Group B). A cluster analysis technique was used to identify four clusters of individuals with different behaviors differentiated by age, total dose of filgrastim required, number of apheresis and harvested CD34+ cells. Results The mean total dose of filgrastim administered was 105 mcg/Kg, the median number of apheresis was 2 procedures and the mean number of harvested stem cells was 4.98 x 106 CD34+ cells/Kg. No significant differences were observed between Groups A and B regarding the number of apheresis, harvested CD34+ cells and number of mobilization failures, however the total dose of filgrastim was significantly lower in Group B. Conclusions Among other factors, the origin of the cytokine used as mobilizing agent is an element to be considered when evaluating CD34+ cell mobilization results. PMID:23049356

  8. Higher dietary intake of vitamin D may influence total cholesterol and carbohydrate profile independent of body composition in men with Chronic Spinal Cord Injury.

    Science.gov (United States)

    Beal, Christopher; Gorgey, Ashraf; Moore, Pamela; Wong, Nathan; Adler, Robert A; Gater, David

    2018-07-01

    A case-control design. To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). 20 male, paraplegic (T3-L1) with chronic (> one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution. Individuals in both groups were matched based on age, weight, time since injury and level of injury. Sg, Si and lipid profiles were measured of the two groups. The high vitamin D group had an average intake of 5.33 ± 4.14 mcg compared to low vitamin D group, 0.74 ± 0.24 mcg. None of the 20 participants met the recommended guidelines for daily vitamin D intake. The higher vitamin D group had a significantly lower (P = 0.035) total cholesterol (148.00 ± 14.12 mg/dl) than the lower vitamin D group (171.80 ± 36.22 mg/dl). Vitamin D adjusted to total dietary intake was positively correlated to improvement in Si and Sg (PD intake. However, a higher dietary intake of vitamin D may influence total cholesterol and carbohydrate profile as demonstrated by a significant decrease in total cholesterol and improvement in glucose homeostasis independent of body composition changes after SCI.

  9. The thyroid registry: Clinical and hormonal characteristics of adult indian patients with hypothyroidism

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    Bipin Sethi

    2017-01-01

    Full Text Available Objectives: Appropriate treatment of hypothyroidism requires accurate diagnosis. This registry aimed to study the disease profile and treatment paradigm in hypothyroid patients in India. Materials and Methods: We registered 1500 newly diagnosed, treatment-naïve, adult hypothyroid males and nonpregnant females across 33 centers and collected relevant data from medical records. The first analysis report on baseline data is presented here. Results: The mean age of the study population was 41.1 ± 14.01 years with a female to male ratio of 7:3. The most frequently reported symptoms and signs were fatigue (60.17% and weight gain with poor appetite (36.22%. Menstrual abnormalities were reported in all women (n = 730 who had not attained menopause. Grades 1 and 2 goiter (as per the WHO were observed in 15.41% and 3.27% patients, respectively. Comorbidities were reported in 545 patients (36.36%, type 2 diabetes mellitus being the most prevalent (13.54% followed by hypertension (11.34%. Total serum thyroxine (T4 and thyroid-stimulating hormone (TSH levels were assessed in 291 (19.47% patients only. In majority of patients (81%, treatment was based on serum TSH levels alone. The dose of levothyroxine ranged from 12.5 to 375 mcg. Conclusions: Guidelines suggest a diagnosis of hypothyroidism based on TSH and T4 levels. However, most of the patients as observed in this registry received treatment with levothyroxine based on TSH levels alone, thus highlighting the need for awareness and scientific education among clinicians in India. The use of standard doses (100, 75, and 25 mcg of levothyroxine may point toward empirical management practices.

  10. Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial

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    Decramer Marc

    2011-01-01

    Full Text Available Abstract Background Debate continues as to whether acute bronchodilator responsiveness (BDR predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR. Methods At baseline and during the 4-year Understanding Potential Long-term Improvements in Function with Tiotropium (UPLIFT® trial, patients had spirometry performed before and after administration of ipratropium bromide 80 mcg and albuterol 400 mcg. Patients were split according to three BDR thresholds: ≥12% + ≥200 mL above baseline (criterion A, ≥15% above baseline (criterion B; and ≥10% absolute increase in percent predicted FEV1 values (criterion C. Several outcomes (pre-dose spirometry, exacerbations, St. George's Respiratory Questionnaire [SGRQ] total score were assessed according to presence or absence of BDR in the treatment groups. Results 5783 of 5993 randomized patients had evaluable pre- and post-bronchodilator spirometry at baseline. Mean age (SD was 64 (8 years, with 75% men, mean post-bronchodilator FEV1 1.33 ± 0.44 L (47.6 ± 12.7% predicted and 30% current smokers. At baseline, 52%, 66%, and 39% of patients had acute BDR using criterion A, B, and C, respectively. The presence of BDR was variable at follow-up visits. Statistically significant improvements in spirometry and health outcomes occurred with tiotropium regardless of the baseline BDR or criterion used. Conclusions A large proportion of COPD patients demonstrate significant acute BDR. BDR in these patients is variable over time and differs according to the criterion used. BDR status at baseline does not predict long-term response to tiotropium. Assessment of acute BDR should not be used as a decision-making tool when prescribing tiotropium to patients with COPD.

  11. Pattern of airway inflammation and remodelling in mild persistent atopic asthma and in mild persistent asthma related to gastroesophageal reflux.

    Science.gov (United States)

    Dal Negro, R W; Guerriero, M; Micheletto, C

    2012-12-01

    The increase of basement membrane thickness (BMAT) represents a structural feature described as commonly characterizing airway remodelling in asthma, even if the non-atopic condition had been investigated only episodically from this point of view. Gastrooesophageal-reflux is a pathological condition which can frequently cause and/or sustain asthma in non-atopic individuals. The aim of the study was to measure BMT; some inflammatory mediators in BAL; cys-leucotrienes (LTE4) in urine; e-NO, and BHR to Methacholine (MCh) in mild atopic and in mild non-atopic, GER-related asthma. After their informed consent, 25 mild atopic (40.9 years +/- 13.1 sd, FEV1 = 95.9% pred. +/- 12.9 sd) and 39 non-atopic, GER-related asthmatics (57.3 years +/- 14.2 ds, FEVY1 = 101.3% pred. +/- 12.2 sd), nonsmoker and of a comparable asthma duration, underwent measurements of basal lung function and bronchial response to MCh (PD20 FEV1); endobronchial biopsies and BAL (in the right middle lobe), and a 24-h gastroesophageal pHmetry. Atopic GER-related asthma showed two distinct patterns of airway inflammation. The eosinophilic contribution to airway inflammation was systematically prevailing in the former group, such as: EOS = 10.7% +/- 13.4 sd vs 2.0% +/- 2.8 sd, p = 0.001; ECP = 344.9 mcg/l +/- 635.9 sd vs 59.2 mcg/l +/- 75.1 sd, p = 0.001. Data from the present study are suggesting that persistent mild atopic and mild GER-related asthma seem to represent two distinct phenotypes of asthma in terms of airway remodelling, and in particular of BMT involvement.

  12. Comparison of the effects of magnesium sulphate and dexmedetomidine on surgical vision quality in endoscopic sinus surgery: randomized clinical study

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    Akcan Akkaya

    2014-12-01

    Full Text Available Background and objectives: Even a small amount of bleeding during endoscopic sinus surgery can corrupt the endoscopic field and complicate the procedure. Various techniques, including induced hypotension, can minimize bleeding during endoscopic sinus surgery. The aim of this study was to compare the surgical vision quality, haemodynamic parameters, postoperative pain, and other effects of magnesium, a hypotensive agent, with that of dexmedetomidine, which was initially developed for short-term sedation in the intensive care unit but also is an alpha 2 agonist sedative. Method: 60 patients between the ages of 18 and 45 years were divided into either the magnesium group (Group M or the dexmedetomidine group (Group D. In Group M, magnesium sulphate was given at a pre-induction loading dose of 50 mg kg−1 over 10 min and maintained at 15 mg kg−1 h−1; in Group D, dexmedetomidine was given at 1 mcg kg−1 10 min before induction and maintained at 0.6 mcg kg−1 h−1. Intraoperatively, the haemodynamic and respiratory parameters and 6-point intraoperative surgical field evaluation scale were recorded. During the postoperative period, an 11-point numerical pain scale, the Ramsay sedation scale, the nausea/vomiting scale, the adverse effects profile, and itching parameters were noted. Results: Group D showed a significant decrease in intraoperative surgical field evaluation scale scale score and heart rate. The average operation time was 50 min, and Group M had a higher number of prolonged surgeries. No significant difference was found in the other parameters. Conclusions: Due to its reduction of bleeding and heart rate in endoscopic sinus surgery and its positive impacts on the duration of surgery, we consider dexmedetomidine to be a good alternative to magnesium.

  13. To evaluate the efficacy of intrathecal magnesium sulphate for hysterectomy under subarachnoid block with bupivacaine and fentanyl: A prospective randomized double blind clinical trial

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    Mridu Paban Nath

    2012-01-01

    Full Text Available Background: Intrathecal magnesium has been found to prolong the duration of analgesia in various surgical procedures like lower limb surgeries and as adjuncts to general anesthesia for pain management. The present study was designed to examine whether addition of intrathecal magnesium sulfate would enhance the analgesic efficacy of intrathecal bupivacaine and fentanyl in patients undergoing total abdominal hysterectomy. Methods: After taking informed consent, 60 patients were randomised into two groups with 30 patients. Group "S" received 2.5 mL (12.5 mg of hyperbaric bupivacaine + 0.5 mL (25 mcg of fentanyl + 0.5 mL of normal saline and Group "M" received 2.5 mL (12.5 mg of hyperbaric bupivacaine + 0.5 mL (25 mcg of fentanyl + 0.5 mL (100 mg of magnesium sulfate. Onset of sensory, motor block and duration of analgesia was noted. Results: Demographic profile and duration of surgery were comparable (P>0.5. Time of onset of sensory and motor blockade was delayed in Group M compared with Group S, and this was statistically significant. A statistically significant longer duration of analgesia was observed in Group M compared with the control Group S. However, the recovery of motor blockade was found to be statistically insignificant in both the groups. The hemodynamic parameters were comparable in the perioperative period (P>0.05. The incidence of side-effects in both the groups were also comparable (P>0.05. Conclusion: The addition of 100 mg intrathecal magnesium led to prolonged duration of analgesia significantly without increasing the incidence of side-effects. Also, there was a significant delay in the onset of both sensory and motor blockade.

  14. Pooled comparison of regadenoson versus adenosine for measuring fractional flow reserve and coronary flow in the catheterization laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Stolker, Joshua M., E-mail: jstolker@yahoo.com [Mercy Heart and Vascular, 901 Patients First Drive, Washington, MO 63090 (United States); Saint Louis University, 3635 Vista Ave, St. Louis, MO 63110 (United States); Lim, Michael J., E-mail: limmj@slu.edu [Saint Louis University, 3635 Vista Ave, St. Louis, MO 63110 (United States); Shavelle, David M., E-mail: david.shavelle@med.usc.edu [University of Southern California, 1510 San Pablo St, Suite 322, Los Angeles, CA 90033 (United States); Morris, D. Lynn, E-mail: morrisdl@einstein.edu [Albert Einstein Medical Center, 5501 Old York Rd, Philadelphia, PA 19141 (United States); Angiolillo, Dominick J., E-mail: dominick.angiolillo@jax.ufl.edu [University of Florida Health-Jacksonville, 655 West 8th St, Jacksonville, FL 32209 (United States); Guzman, Luis A., E-mail: luis.guzman@jax.ufl.edu [University of Florida Health-Jacksonville, 655 West 8th St, Jacksonville, FL 32209 (United States); Kennedy, Kevin F., E-mail: kfkennedy@saint-lukes.org [Saint Luke' s Mid America Heart Institute, 4401 Wornall Road, Kansas City, MO 64111 (United States); Weber, Elizabeth, E-mail: eweber1@slu.edu [Saint Louis University, 3635 Vista Ave, St. Louis, MO 63110 (United States); Zareh, Meena, E-mail: meena.zareh@med.usc.edu [University of Southern California, 1510 San Pablo St, Suite 322, Los Angeles, CA 90033 (United States); Neumayr, Robert H., E-mail: robneumayr@gmail.com [Mercy Heart and Vascular, 901 Patients First Drive, Washington, MO 63090 (United States); Saint Louis University, 3635 Vista Ave, St. Louis, MO 63110 (United States); Zenni, Martin M., E-mail: martin.zenni@jax.ufl.edu [University of Florida Health-Jacksonville, 655 West 8th St, Jacksonville, FL 32209 (United States)

    2015-07-15

    Background: Adenosine is the gold standard for augmenting coronary flow during fractional flow reserve (FFR) testing of intermediate coronary stenoses. However, intravenous infusion is time-consuming and intracoronary injection is subject to variability. Regadenoson is a newer adenosine alternative administered as a single intravenous bolus during nuclear stress testing, but its efficacy and safety during FFR testing have been evaluated only in small, single-center studies. Methods: We pooled data from 5 academic hospitals, in which patients undergoing clinically-indicated FFR prospectively underwent comparison of intravenous adenosine infusion (140–175 mcg/kg/min) versus regadenoson bolus (400 mcg). Hemodynamics and symptoms with adenosine were recorded until maximal hyperemia occurred, and after returning to baseline hemodynamics, regadenoson was administered and monitoring was repeated. In a subset of patients with coronary flow data, average peak velocity (APV) at the distal flow sensor was recorded. Results: Of 149 patients enrolled, mean age was 59 ± 9 years, 76% were male, and 54% underwent testing of the left anterior descending artery. Mean adenosine-FFR and regadenoson-FFR were identical (0.82 ± 0.10) with excellent correlation of individual values (r = 0.96, p < 0.001) and no difference in patient-reported symptoms. Four patients (2.6%) had discrepancies between the 2 drugs for the clinical decision-making cutoff of FFR ≤ 0.80. Coronary flow responses to adenosine and regadenoson were similar (APV at maximal hyperemia 36 cm/s for both, p = 0.81). Conclusions: Regadenoson single-bolus administration has comparable FFR, symptoms, and coronary flow augmentation when compared with standard intravenous adenosine infusion. With its greater ease of administration, regadenoson may be a more “user-friendly” option for invasive ischemic testing.

  15. The value of adrenaline in the induction of supraventricular tachycardia in the electrophysiological laboratory.

    Science.gov (United States)

    Cismaru, Gabriel; Rosu, Radu; Muresan, Lucian; Puiu, Mihai; Andronache, Marius; Hengan, Erika; Ispas, Daniel; Gusetu, Gabriel; Pop, Dana; Mircea, Petru Adrian; Zdrenghea, Dumitru

    2014-11-01

    The most commonly used drug for the facilitation of supraventricular tachycardia (SVT) induction in the electrophysiological (EP) laboratory is isoprenaline. Despite isoprenaline's apparent indispensability, availability has been problematic in some European countries. Alternative sympatomimethic drugs such as adrenaline have therefore been tried. However, no studies have determined the sensitivity and specificity of adrenaline for the induction of SVT. The objective of this study was to determine the sensitivity and specificity of adrenaline for the induction of SVT. Between February 2010 and July 2013, 336 patients underwent an EP study for prior documented SVT. In 66 patients, adrenaline was infused because tachycardia was not induced under basal conditions. This group was compared with 30 control subjects with no history of SVT. Programmed atrial stimulation was carried out during baseline state and repeated after an infusion of adrenaline (dose ranging from 0.05 mcg/kgc to 0.3 mcg/kgc). The endpoint was the induction of SVT. Among 66 patients with a history of SVT but no induction under basal conditions, adrenaline facilitated induction in 54 patients (82%, P Adrenaline was generally well tolerated, except for two patients (3.0%), where it had to be discontinued due to headache and high blood pressure or lumbar pain. Adrenaline infusion has a high sensitivity (82%) and specificity (100%) for the induction of SVT in patients with prior documented SVT. Therefore, it could serve as an acceptable alternative to isoprenaline, when the latter is not available. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  16. Comparison of efficacy of bupivacaine and fentanyl with bupivacaine and sufentanil for epidural labor analgesia

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    Kalra Sumit

    2010-01-01

    Full Text Available Objectives: A study to compare the efficacy between fentanyl and sufentanil combined with low concentration (0.0625% of bupivacaine for epidural labor analgesia in laboring women. Materials and Methods: Fifty full term parturients received an initial bolus dose of a 10 ml solution containing 0.125% bupivacaine. The patients were randomly divided into two: group F received 0.0625% bupivacaine with 2.5 mcg/ml fentanyl and group S received 0.0625% bupivacaine with 0.25 mcg/ml sufentanil. Verbal analogue pain scores, need of supplementary/rescue boluses dose of bupivacaine consumed, mode of delivery, maternal satisfaction, and neonatal Apgar scores were recorded. No significant difference was observed between both groups. Results: Both the groups provided equivalent labor analgesia and maternal satisfaction. The chances of cesarean delivery were also not increased in any group. No difference in the cephalad extent of sensory analgesia, motor block or neonatal Apgar score were observed. Although mean pain scores throughout the labor and delivery were similar in both groups, more patients in fentanyl group required supplementary boluses though not statistically significant. Conclusion: We conclude that both 0.0625% bupivacaine-fentanyl (2.5 μg/ml and 0.0625% bupivacaine-sufentanil (0.25 μg/ml were equally effective by continuous epidural infusion in providing labor analgesia with hemodynamic stability achieving equivalent maternal satisfaction without serious maternal or fetal side effects. We found that sufentanil was 10 times more potent than fentanyl as an analgesic for continuous epidural labor analgesia.

  17. Conversion of oral alfacalcidol to oral calcitriol in the treatment of secondary hyperparathyroidism in chronic hemodialysis patients.

    Science.gov (United States)

    Rauscher, Sandrine; Lafrance, Jean-Philippe; Pichette, Vincent; Bell, Robert Z; Desforges, Katherine; Lepage, Laurence; Ouellet, Georges; Ouimet, Denis; Leblanc, Martine; Lamarche, Caroline; Bezzaoucha, Sarah; Vallee, Michel

    2017-02-01

    The optimal vitamin D 3 therapy for the treatment of secondary hyperparathyroidism (SHPT) in chronic hemodialysis patients is still controversial. Recent studies suggest that uremia in end-stage renal disease is associated with enzymatic hepatic dysfunction altering 25-hydroxylation of vitamin D 3 . The goal of our study was to compare the efficacy of calcitriol, the fully hydroxylated active form of vitamin D 3 , to alfacalcidol which needs 25-hydroxylation to be effective, for the treatment of SHPT in chronic hemodialysis patients. We retrospectively reviewed 45 chronic hemodialysis patients who were switched from oral alfacalcidol to oral calcitriol for the treatment of SHPT. Parathyroid hormone (PTH), serum calcium and serum phosphorus levels were compared pre- and post-conversion using paired Student's t tests. The mean dose of active vitamin D 3 decreased from 3.50 mcg/week at baseline to 2.86 mcg (P < 0001) after the switch from alfacalcidol to calcitriol. PTH significantly decreased from 94.4 to 82.6 pmol/L (-11.8 pmol/L, P = 0.02). The mean corrected calcium increased from 2.17 to 2.25 mmol/L (+0.08 mmol/L, P < 0.001) without any clinically significant hypercalcemia, and phosphorus levels were stable. Results were similar in a subgroup of patients (n = 17) for whom the medication was administrated during the hemodialysis session, ensuring a complete compliance. According to our study, calcitriol in equal dosage is more effective than alfacalcidol in lowering serum PTH level in chronic hemodialysis patients. This suggests that calcitriol may be the optimal active vitamin D 3 for the treatment of SHPT in chronic hemodialysis patients.

  18. Use of simulated patients to evaluate combined oral contraceptive dispensing practices of community pharmacists.

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    Paulo Roque Obreli-Neto

    Full Text Available BACKGROUND: Combined oral contraceptive (COC use is the most commonly used reversible method of birth control. The incorrect use of COCs is frequent and one of the most common causes of unintended pregnancies. Community pharmacists (CPs are in a strategic position to improve COC use because they are the last health professional to interact with patients before drug use. OBJECTIVE: To evaluate the COC dispensing practices of CPs in a developing country. METHOD: A cross-sectional study was conducted in community pharmacies of Assis and Ourinhos microregions, Brazil, between June 1, 2012, and October 30, 2012. Four simulated patients (SPs (with counseled audio recording visited community pharmacies with a prescription for Ciclo 21(® (a COC containing ethinyl estradiol 30 mcg + levonorgestrel 15 mcg. The audio recording of every SP visit was listened to independently by 3 researchers to evaluate the COC dispensing practice. The percentage of CPs who performed a screening for safe use of COCs (i.e., taking of patients' medical and family history, and measuring of blood pressure and provided counseling, as well as the quality of the screening and counseling, were evaluated. RESULTS: Of the 185 CPs contacted, 41 (22.2% agreed to participate in the study and finished the study protocol. Only 3 CPs asked the SP a question (1 question asked by each professional, and all of the questions were closed-ended, viz., "do you smoke?" (n = 2 and "what is your age?" (n = 1. None of the CPs measured the patient's blood pressure. Six CPs provided counseling when dispensing COCs (drug dosing, 5 CPs; possible adverse effects, 2 CPs, and one CP provided counseling regarding both aspects. CONCLUSION: The CPs evaluated did not dispense COC appropriately and could influence in the occurrence of negatives therapeutic outcomes such as adverse effects and treatment failure.

  19. Effect of biodiesel fuel on "real-world", nonroad heavy duty diesel engine particulate matter emissions, composition and cytotoxicity.

    Science.gov (United States)

    Martin, Nathan; Lombard, Melissa; Jensen, Kirk R; Kelley, Patrick; Pratt, Tara; Traviss, Nora

    2017-05-15

    Biodiesel is regarded by many as a "greener" alternative fuel to petroleum diesel with potentially lower health risk. However, recent studies examining biodiesel particulate matter (PM) characteristics and health effects are contradictive, and typically utilize PM generated by passenger car engines in laboratory settings. There is a critical need to analyze diesel and biodiesel PM generated in a "real-world" setting where heavy duty-diesel (HDD) engines and commercially purchased fuel are utilized. This study compares the mass concentrations, chemical composition and cytotoxicity of real-world PM from combustion of both petroleum diesel and a waste grease 20% biodiesel blend (B20) at a community recycling center operating HDD nonroad equipment. PM was analyzed for metals, elemental/organic carbon (EC/OC), polycyclic aromatic hydrocarbons (PAHs), and nitro-polycyclic aromatic hydrocarbons (N-PAHs). Cytotoxicity in a human lung epithelial cell line (BEAS-2B) following 24h exposure to the real-world particles was also evaluated. On average, higher concentrations for both EC and OC were measured in diesel PM. B20 PM contained significantly higher levels of Cu and Mo whereas diesel PM contained significantly higher concentrations of Pb. Principal component analysis determined Mo, Cu, and Ni were the metals with the greatest loading factor, suggesting a unique pattern related to the B20 fuel source. Total PAH concentration during diesel fuel use was 1.9 times higher than during B20 operations; however, total N-PAH concentration was 3.3 times higher during B20 use. Diesel PM cytotoxicity was 8.5 times higher than B20 PM (pengine sources of metals, PAH and N-PAH species, comparing tailpipe PM vs. PM collected inside the equipment cabin. Results suggest PM generated from burning petroleum diesel in nonroad engines may be more harmful to human health, but the links between exposure, composition and toxicity are not straightforward. Copyright © 2016 Elsevier B.V. All rights

  20. Effects of a biodiesel blend on energy distribution and exhaust emissions of a small CI engine

    International Nuclear Information System (INIS)

    Magno, Agnese; Mancaruso, Ezio; Vaglieco, Bianca Maria

    2015-01-01

    Highlights: • B20 does not affect the brake thermal efficiency and the engine energetic flows with respect to diesel fuel. • B20 is characterized by lower combustion noise than diesel fuel. • B20 emits lower CO, HC and PM in the most of the operating conditions. • A definite trend of NO x emissions for B20 with respect to diesel fuel was not found. • B20 emits more nuclei particles than diesel fuel. - Abstract: This paper investigates the energy distribution and the waste heat energy characteristics of a compression ignition engine for micro-cogeneration applications, at different engine speeds and loads. The experimental activity was carried out on a three-cylinder, 1028 cc, common-rail engine. Tests were performed with diesel fuel and a 20% v/v biodiesel blend (B20). The quantity and the quality of the waste heat energy were studied through energy and exergy analyses, respectively. Combustion characteristics were investigated by means of indicating data. Gaseous emissions were measured and particles were characterized in terms of number and size at exhaust. It was found out that the addition of 20% v/v of RME to diesel fuel does not affect significantly the brake fuel conversion efficiency and the energetic flows. On the other hand, biodiesel blend allows to reduce the combustion noise and the pollutants emissions in most of the operating conditions. A proper phasing of the injection strategy for the biodiesel blend could further reduce the exhaust emissions, mainly at high engine speeds. The results presented in this paper could be useful for the development of diesel engine based micro-cogeneration systems working at different engine speeds and loads