EKA - suur tükk ajab suu lõhki / Tuuli Jõesaar

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Jõesaar, Tuuli

2011-01-01

Eesti Kunstiakadeemia uue hoone arhitektuurikonkursi võidutöö "Art Plaza" projekti muutmisest. Kadunud on korruseid läbinud avatud aatrium. Uuenenud plaanid ei ole veel EKA nõukogu ette jõudnud. Projektis saab muudatusi teha töö autor (Taani bürood SEA ja Effekt koos AET Arhitektide ja Allianss Arhitektidega) koostöös dekaanide, õppejõudude ja tehniliste ekspertidega. Lisandunud on tudengite algatusrühm

WATER QUALITY AND ITS EFFECT ON GROWTH AND SURVIVAL RATE OF LOBSTER REARED IN FLOATING NET CAGE IN EKAS BAY, WEST NUSA TENGGARA PROVINCE

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Muhammad Junaidi

2015-02-01

Full Text Available ABSTRACT The development of lobster farming in floating net cage in Ekas Bay caused an environmental degradation such as decrease water quality due to some aquaculture wastes. The purposes of this study were to determine the status of water quality and their effect on growth and survival rate of lobster reared in floating net cages (FNC in the Ekas Bay, West Nusa Tenggara Province. Water sample collection and handling referred to the APHA (1992. Analyses of water quality data were conducted using Principal Component Analysis. Determination of the water quality status of Ekas Bay was performed with STORET system. Multivariate analyses were used to determine the relationship between water quality, growth, and survival rate of lobster reared in FNC. Results showed that Ekas Bay water quality status was categorized in class C (medium contaminated, which exceeded some quality standard parameters such as ammonia (0.3 mg/l, nitrate (0.008 mg/l, and phosphate (0.015 mg/l. During lobster farming activities feeding with trash fish for 270 days, we obtained daily growth rate of  0.74% (lower than normal growth rate of 0.86%, survival rate of 66% (lower than normal survival rate of 86.7%, and feed conversion ratio of 11.15. Ammonia was found as a dominant factor reducing growth  and survival rate of lobster reared in FNC. Keywords: water quality, lobsters, growth, survival, Ekas Bay

In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma

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Nestor, M.; Anniko, M. [Uppsala University, Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala (Sweden); Persson, M. [Uppsala University, Unit of Urology, Department of Surgical Sciences, Uppsala (Sweden); Uppsala University, Unit of Biomedical Radiation Science, Department of Oncology, Radiology and Clinical Immunology, Uppsala (Sweden); Dongen, G.A.M.S. van [Vrije Universiteit Medical Center, Department of Otolaryngology/Head and Neck Surgery, Amsterdam (Netherlands); Jensen, H.J. [Righshospitalet, PET and Cyclotron Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen (Denmark); Lundqvist, H.; Tolmachev, V. [Uppsala University, Unit of Biomedical Radiation Science, Department of Oncology, Radiology and Clinical Immunology, Uppsala (Sweden)

2005-11-01

The purpose of this study was to analyse the properties of the astatinated chimeric MAb (cMAb) U36 as a conjugate to selectively target and eradicate head and neck squamous cell carcinoma (HNSCC). cMAb U36 was labelled with {sup 211}At via the linker N-succinimidyl 4-(trimethylstannyl)benzoate (SPMB). The quality of the conjugate was extensively evaluated for binding and internalisation capacity, and compared with {sup 125}I-SPMB-cMAb U36. The cellular toxicity of the astatinated conjugate was assessed in two types of in vitro growth assay and compared with {sup 131}I-labelled cMAb U36 (directly labelled). Comparisons between {sup 211}At-cMAb U36 and {sup 125}I-cMAb U36 demonstrated an optimal functional capacity of the labelled products. Immunoreactivity and affinity assays showed high immunoreactive fractions (>93%), and an affinity in good agreement between the astatinated and iodinated antibodies. For both conjugates, specific binding to HNSCC cells could be demonstrated, as well as some internalisation. Retention of the astatinated conjugate was just slightly lower than for the iodinated conjugate and still reasonable for therapeutic use (31{+-}2% vs 42.6{+-}1.0% at 22 h), demonstrating no adverse effects from astatination of the antibody. Studies on cellular toxicity demonstrated a dose-dependent and antigen-specific cellular toxicity for {sup 211}At-cMAb U36, with about 10% cell survival at 50 decays per cell. The {sup 131}I-labelled conjugate was not as efficient, with a surviving cell fraction of about 50% at 55 decays per cell. (orig.)

ASPEK REPRODUKSI LOBSTER (Panulirus sp. DI PERAIRAN TELUK EKAS PULAU LOMBOK

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M Junaidi

2010-04-01

Full Text Available Purposes of this research are to know some reproduction aspects of lobster, including sex ratio, gonad maturity level, size of first gonad mature, fekundity, and relationship of length-weight some. This research was conducted in June until November 2009 in Ekas Bay. During research 5 lobsters species were obtained, they are Panulirus homarus, P. versicolor, P. ornatus P. penicillatus and P. longiceps, with their of is well-balanced (1:1. Size of first gonad mature of P. homarus at carapace length 77,44 mm that happened during June - November with fekundity 28.000 - 96.000 granule, P. versicolor at carapace length 82,20 mm that happened during June - September with fekundity 16.500 - 71.000 granule, P. ornatus at carapace length 76,74 mm that happened during September - November with fekundity 47.000 - 87.000 granule, P. penicillatus at carapace length 69,84 mm that happened during June - November with fekundity 31.000 - 150.000 granule and P. longiceps at carapace length 68,47 mm that happened in June - August with fekundity 47.000 - 140.000 granule. Relationship of carapace length and body weight of five species, also male and female was described using linier regression equation and have negative allometrict pattern, where accretion of carapace length was quicker than body weight accretion.Keyword : reproduction aspect, lobster, Ekas Bay

DECONSTRUCTING THE IDEOLOGY OF RESISTANCE SHOWN BY THE PEOPLE LIVING AT CANDIKUNING VILLAGE TO THE MANAGEMENT OF EKA KARYA BALI BOTANICAL GARDEN

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I Wayan Sujana

2016-02-01

Full Text Available The people living at Candikuning Village are not involved in the management of the Eka Karya Bali Botanical Garden; however, they intend to enjoy the retribution which is received by the Botanical Garden, for which they show their resistance to the management. This article is intended to understand the ideology which has inspired the local people to argue that they are entitled to the retribution received by the Eka Karya Bali Botanical Garden.  The data were collected through in-depth interview, observation, and documentation techniques. The data were critically analyzed using the deconstruction method. Based on the analysis of the facts which had inspired the resistance shown by the local people living at Candi Kuning Village to the management of the Bali Eka Karya Botanical Garden, it could be understood that the geopolitical ideology was used as the basis of the resistance. Therefore, the management of the Bali Eka Karya Botanical Garden should give some of the retribution they received to the local people. The Botanical garden is located at Candikuning Village or part of the area of Candikuning Village. However, the village had never received any retribution from the Botanical Garden. The management should remember the proverb “di mana bumi dipijak di situ langit dijunjung” (we should adjust ourselves to the environment where we stay, based on the philosophy of Tri Hita Karana, meaning that the management should give retribution to the temple located at the area of the Botanical Garden.

High-efficiency astatination of antibodies using N-iodosuccinimide as the oxidising agent in labelling of N-succinimidyl 3-(trimethylstannyl)benzoate

International Nuclear Information System (INIS)

Lindegren, S.; Andersson, H.; Baeck, T.; Jacobsson, L.; Karlsson, B.; Skarnemark, G.

2001-01-01

Monoclonal antibodies C215, reactive with colorectal carcinomas, and MOv18, reactive with most of the ovarian carcinomas, were radiohalogenated with [ 211 At]astatine. The radiohalogen was conjugate coupled to antibodies via the intermediate labelling reagent N-succinimidyl-3-(trimethylstannyl)benzoate (m-MeATE) in a two-step, single-pot reaction. Optimisation of the labelling of the reagent was achieved using N-iodosuccinimide, NIS, as the oxidising agent. The yields ranged from 69-95% in the labelling of 0.1-1.0 nmole of the m-MeATE precursor. Subsequent conjugation to antibodies resulted in yields of 58±7%. In vitro binding to tumour cells showed that the immunoreactivity of both antibodies was retained after astatine labelling

211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

International Nuclear Information System (INIS)

Pruszynski, M.; Bilewicz, A.

2006-01-01

211 At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211 At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At - to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh 3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At - anions, but first of all because of the kinetic inertness of low spin rhodium(III) d 6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh 3+ . The experiments related to optimization of the reaction conditions were performed with the 131 I, basing on a chemical similarity of I - to At - . The experiments with 211 At were then carried out under the conditions found optimal for I - . The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211 At-Rh(16-S4-diol) complex

Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

Czech Academy of Sciences Publication Activity Database

Sjostrom, A.; Tolmachev, V.; Lebeda, Ondřej; Koziorowski, J.; Carlsson, J.; Lundqvist, H.

2003-01-01

Roč. 256, č. 7 (2003), s. 191-197 ISSN 0236-5731 R&D Projects: GA AV ČR KSK4055109 Keywords : neutron-capture therapy * astatine-211 Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.472, year: 2003

Planning of Eka Hospital Pekanbaru wastewater recycling facility

Science.gov (United States)

Jecky, A.; Andrio, D.; Sasmita, A.

2018-04-01

The Ministry of Public Works No. 06 2011 required the large scale of water to conserve the water resource, Eka Hospital Pekanbaru have to improve the sewage treatment plant through the wastewater recycling. The effluent from the plant can be used to landscape gardening and non-potable activities. The wastewater recycling design was done by analyzing the existing condition of thesewage treatment plant, determine the effluent quality standards for wastewater recycling, selected of alternative technology and processing, design the treatment unit and analyze the economic aspects. The design of recycling facility by using of combination cartridge filters processing, ultrafiltration membranes, and desinfection by chlorination. The wastewater recycling capacity approximately of 75 m3/day or 75% of the STP effluent. The estimated costs for installation of wastewater recycling and operation and maintenance per month are Rp 111,708,000 and Rp 2,498,000 respectively.

An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

International Nuclear Information System (INIS)

Rothe, Sebastian

2012-01-01

This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

CERN Document Server

Rothe, Sebastian; Nörtershäuser, W

This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

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Rothe, Sebastian

2012-09-24

This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

Determination of the electron affinity of astatine and polonium by laser photodetachment

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We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

Thermogravimetric determination of the enthalpy of astatine and radon adsorption on palladium surfaces

International Nuclear Information System (INIS)

Eichler, B.; Son Chun, K.

1985-01-01

In order to investigate the adsorption of astatine and radon on a palladium surface some on- and off-line thermochromatographic experiments were carried out with 210 At and 220 Rn tracers. The partial molar adsorption enthalpy for zero covering was found to be ΔH/sub a//sup 0, loc./(At) = -(15S +- 10) kJ mole -1 and ΔH/sub a//sup 0, mob./(Rn) = -(37 +- 4) kJ mole -1 . The results are compared with theoretical and experimental values for other elements of the sixth period. The adsorption behaviour of At is in conformity with that of the p-metals on a palladium surface. (author)

Estimation of the chemical form and the boiling point of elementary astatine by radiogas-chromatography

International Nuclear Information System (INIS)

Otozai, K.; Takahashi, N.

1982-01-01

After astatine (0) was mixed with 131 I 2 containing carrier I 2 , the sample was analyzed by means of radiogaschromatography and the peaks due to I 2 , AtI and At 2 were observed. Further, the boiling points were estimated from the retention volume in terms of the semi-empirical theory on gas chromatography. The boiling points of I 2 , AtI and At 2 were 457 +- 2,486 +- 2 and 503 +- 3K, respectively. The boiling point of At 2 obtained in the present work is far smaller than that expected by the extrapolation of lighter halogens. (orig.)

Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

CERN Multimedia

Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

2017-01-01

Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

EKA 90. aastapäeva juubelinädalale on planeeritud mitmeid üritusi nii peamajas kui osakondades

Index Scriptorium Estoniae

2004-01-01

Kunstööstuskooli tutvustavast näitusest. 29. X audoktorite Udo Kultermanni ja Juhani Pallasmaa loengud ning ümarlaua ettekanded (osalejad loetletud), ümarlauda juhib Jüri Soolep. EKA galeriis valgusinstallatsioonide näitus "Think Lightly", osalevad Sirli Põllumäe, Riho Tiivel, Helis Podnek, Marion Uuspõld, Pent Talvet, Mehis Tiitsar, Merike Rehepapp, Veiko Vaine. Üliõpilaste loomingu väljapanekud. 30. X vilistlaspäev, pidulikul aktusel promoveeritakse audoktoriteks Juhani Pallasmaa, Udo Kultermann, Lars Olof Larsson ja Yrjö Sotamaa. Vabade kunstide osakonna rändnäitus "Ekskursioon" sisekaitseakadeemias

Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

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Andreyev, Andrei

2013-01-01

Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

PENGARUH PELAYANAN, KINERJA PENGURUS KOPERASI, DAN MOTIVASI BERKOPERASI TERHADAP PARTISIPASI ANGGOTA KOPERASI PEGAWAI REPUBLIK INDONESIA (KPRI EKA KARYA KABUPATEN KENDAL

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Tri Yuni Sulistyowati

2015-06-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh pelayanan, kinerja pengurus koperasi, dan motivasi berkoperasi terhadap partisipasi anggota Koperasi Pegawai Republik Indonesia (KPRI Eka Karya Kabupaten Kendal. Penelitian ini merupakan penelitian kuantitatif, dengan populasi berjumlah 496 anggota dengan sampel 83 anggota. Metode pengambilan data yang digunakan adalah kuesioner dan dokumentasi. Metode analisis data menggunakan analisis deskriptif, regresi linier berganda dan uji asumsi klasik. Hasil penelitian menunjukkan bahwa secara simultan terdapat pengaruh pelayanan, kinerja pengurus koperasi, dan motivasi berkoperasi terhadap partisipasi anggota sebesar 58,2%. Secara parsial pelayanan berpengaruh sebesar 7,1%, kinerja pengurus koperasi berpengaruh sebesar 3,3% dan motivasi berkoperasi berpengaruh sebesar 27%. Dengan pelayanan, kinerja pengurus koperasi, dan motivasi berkoperasi yang baik maka akan meningkatkan partisipasi anggota. The results showed the service, the performance of cooperative management and cooperative motivation affect the participation of members simultaneously by 58.2% while the rest is influenced by other variables not examined. Furthermore, the effect of partial services to the participation of members was 7.1%, the effect of partial performance of the cooperative board member participation was 3.3% and the effect of partial motivation for the participation of members of cooperatives was 27%. Suggestions for KPRI Eka Karya Kendal is to be improving as more responsive services tehadap complaints, better hygiene as well as expanding the cooperative store stores that optimal participation of more members.

Complexation study on no-carrier-added astatine with insulin: A candidate radiopharmaceutical

Energy Technology Data Exchange (ETDEWEB)

Lahiri, Susanta [Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064 (India)], E-mail: susanta.lahiri@saha.ac.in; Roy, Kamalika [Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064 (India); Sen, Souvik [Berhampur Sadar Hospital, Berhampur, Murshidabad 742 101 (India)

2008-12-15

No-carrier-added astatine radionuclides produced in the {sup 7}Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about {approx}12 h, when dialyzed against deionized water and is only 6 h, when dialyzed against RL solution having the same composition as blood serum. The 6 h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12 h.

Complexation study on no-carrier-added astatine with insulin: A candidate radiopharmaceutical

International Nuclear Information System (INIS)

Lahiri, Susanta; Roy, Kamalika; Sen, Souvik

2008-01-01

No-carrier-added astatine radionuclides produced in the 7 Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about ∼12 h, when dialyzed against deionized water and is only 6 h, when dialyzed against RL solution having the same composition as blood serum. The 6 h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12 h

ANALISA DAN PERANCANGAN SISTEM AKUNTANSI PENJUALAN, PEMBELIAN DAN KAS PT. BERLIAN EKA SAKTI TANGGUH, MEDAN

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Pwee Leng

2001-01-01

Full Text Available The rise of globalization causes the influence of a company's environment to be wider and more complex. The role of handling information is very dominant in highly competitive situations, especially in the business world. Information has even been accepted as one of the business resources, where the company attempts to optimize the role of information in management decision-making, for planning, operations and even control. With the help of computer technology, the spread of information, which initially was quite limited, can now be distributed according to need. This is also the case in accounting, where accounting information, which before only had a role at the operations control level, now has a role in management control. As a result of the increasing role of information in accounting, a system is needed to organize the accounting information in order to give the company a strategic competitive advantage. Because of that, Berlian Eka Sakti Tangguh, an export-oriented company located in Medan, operating in the cooking oil industry has purposed to upgrade the present system (semi-computerized to become a computerized, on-line system in order to help the company face the ever-increasing competition in the business world. Abstract in Bahasa Indonesia : Derasnya arus globalisasi menyebabkan pengaruh lingkungan usaha di tempat perusahaan beroperasi menjadi semakin luas dan kompleks. Peran penguasaan informasi menjadi sangat dominan dalam persaingan yang ketat, tidak terkecuali dalam dunia bisnis. Bahkan informasi telah diakui sebagai salah satu sumber daya, dimana perusahaan berupaya mengoptimalkan peran informasi dalam pengambilan keputusan manajemen baik untuk perencanaan, pelaksanaan, maupun pengendalian. Dengan bantuan teknologi komputer, penyebaran informasi yang pada awalnya sangat terbatas kini telah dapat didistribusikan sesuai dengan kebutuhan. Demikian pula pada bidang akuntansi, dimana informasi akuntansi yang sebelumnya hanya berperan

Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

Energy Technology Data Exchange (ETDEWEB)

Wilbur, D. Scott [Univ. of Washington, Seattle, WA (United States)

2011-12-14

The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

Astatine-211 Radiochemistry: The Development Of Methodologies For High Activity Level Radiosynthesis

International Nuclear Information System (INIS)

Zalutsky, Michael R.

2012-01-01

Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for α-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the α-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At-labeled targeted

ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

Energy Technology Data Exchange (ETDEWEB)

MICHAEL R. ZALUTSKY

2012-08-08

Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

MEMBANGUN KEUNGGULAN KOMPETITIF CPO MELALUI SUPPLY CHAIN MANAGEMENT: STUDI KASUS DI PT. EKA DURA INDONESIA, ASTRA AGRO LESTARI, RIAU

Directory of Open Access Journals (Sweden)

Setiadi Djohar

2011-08-01

Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Todays, Supply Chain Management (SCM becomes one icon of strategic factors to achieve a competitive advantage. This is a SCM case study in agroindustry especially crude palm oil (CPO at PT. Eka Dura Indonesia (PT EDI, Astra Agro Lestari, Riau. The objectives of study is mapping of SCM problems of PT EDI, especially about value advantage and productivity advantage. Beside that, the objectives is building a SCM simulation model as strategic tool for developing strategy to achieve a competitive advantage. A system approach and modeling is used to analyze SCM problems. This study is successfully to build SCM Model that consist of SCM Strategic Model and SCM Tactic Model. SCM Model is used for simulating some scenarios about site management, supply schedulling, and tank management to CPO forecasting. From this model, the study also develops strategy chain for SCM to achieve a competitive advantage

Liisa Kruusmäe juhuslikult pealt kuuldud hetked / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2011-01-01

Liisa Kruusmäe näitus "Overheard Stories / Pealtkuuldud lood" Tallinnas Draakoni galeriis. 2010. a. Eesti Kunstiakadeemia maaliosakonna lõpetanud Liisa Kruusmägi omandab EKA-s joonistamise alal magistrikraadi

Lugupeetud kunstnikud, arhitektid ja sõbrad!

Index Scriptorium Estoniae

2001-01-01

Eesti Kunstnike Liidu ja Eesti Arhitektide Liidu aastavahetuspeo kava 28. XII. Esinevad Raivo Kelomees (EKA ja Tartu Kõrgema Kunstikooli videoprojektid), EKA moeosakond. Nova Moda esitleb: Ruta Depp, Ketlin Bachman, Riina Põldroos, Kati Simpson

Negative Ion Source Development and Photodetachment Studies at ISOLDE

CERN Document Server

AUTHOR|(CDS)2254068; Hanstorp, Dag; Rothe, Sebastian

Astatine is one of the rarest elements on earth. The small amount of existing astatine is either created in decay chains of heavier elements or artificially. One of its longer lived isotopes, 211At, is of interest for targeted alpha therapy, a method of treating cancer by using the alpha decay of radioactive elements directly at the location of a tumor. However, its chemical properties are yet to be determined due to the short life time of astatine. A milestone towards the determination of the electronegativity of astatine was the measurement of its ionization potential (IP) at CERN-ISOLDE. However, its electron affinity (EA, the binding energy of the additional electron in a negative ion), is still to be measured. In order to determine the EA of radioisotopes by laser photodetachment spectroscopy, the Gothenburg ANion Detector for Affinity measurements by Laser Photodetachment (GANDALPH) has been built in recent years. As a proof-of-principle, the EA of the 128I negative ion, produced at the CERN-ISOLDE rad...

Miks meile vaja maastikuarhitektuuri? = Why do we need landscape architecture? / Reinhard Micheller, Günther Schalk, Katrin Koov

Index Scriptorium Estoniae

Micheller, Reinhard, 1977-

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise ülesande raames on vestlusringis maastikuarhitektuurse osa juhendajad Reinhard Micheller ja Günther Schalk (michellerundschalk, München) ning Katrin Koov (KAVAKAVA, EKA maastikuarhitektuuri õppekava juht)

Kunstiteaduslik doktoritöö EKA-s kaitstud / Ingrid Ruudi

Index Scriptorium Estoniae

Ruudi, Ingrid

2005-01-01

Heie Treier "Kohalik modernsus kunstis. Eesti varamodernistliku kunsti teoreetiline ja ajalooline kontseptualiseerimine ning Karl Pärsimägi paradigmaleidmise perioodil". Juhendaja Thomas McEvilley, eelretsensent Katrin Kivimaa ja Ene Lamp. Oponent Jaak Kangilaski

Development and therapeutic application of internally emitting radiopharmaceuticals

International Nuclear Information System (INIS)

Adelstein, S.J.; Bloomer, W.D.

1980-01-01

This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Among the available α-emitters, astatine-211 appears most promising for testing the efficacy of α-emitters for therapeutic applications because: (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides; (2) it has a half life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells; and (3) α-emission is associated with 100% of its decays. If appropriate biological carriers can be labeled with an alpha emitter such as 211 At, they could be of great utility in several areas of therapeutic medicine where elimination of specific cell populations is desired. While previous attempts to astatinate proteins using standard iodination techniques have been unsuccessful, effective labeling of proteins with astatine by first synthesizing an aryl astatide and then coupling this compound to the protein via an acylation has been achieved. Undergoing current investigation are several different aryl astatide-followed-by-acylation approaches including an astatinated Bolton-Hunter type reagent using concanavalin A (ConA) and melanocyte stimulating hormone (MSH) as model compounds

Kaasaegse Kunsti Eesti Keskus kui kunstidiiler / Rael Artel, Kai Kaljo, Marco Laimre, Marge Monko ; intervjueerinud Reet Varblane

Index Scriptorium Estoniae

2010-01-01

Vestlusringis osalenud vabakutseline kuraator Rael Artel, Tallinna Ülikooli dotsent, kunstnik Kai Kaljo, EKA fotoosakonna professor, kunstnik Marco Laimre ja EKA fotoosakonna dotsent, kunstnik Marge Monko arutavad, millist rolli peaks KKEK täitma praegu, 21. sajandi teisel kümnendil avatud maailma tingimustes

Kunst on töö hing / Signe Kivi

Index Scriptorium Estoniae

Kivi, Signe, 1957-

2009-01-01

Eesti Kunstiakadeemia 95. Kunstikõrgkooli minevikust, olevikust ja tulevikust, 95. aastapäeva tähistamisest. 10. detsembril promoveeritakse EKA audoktoriteks Helsingi ülikooli emeriitprofessor Riitta Nikula ja Leideni ülikooli graafilise disaini õppejõud Gerard Unger. Uueks EKA auliikmeks on nimetatud Meelis Milder

Joonistamine Narvas

Index Scriptorium Estoniae

2003-01-01

EKA korraldatud aktsioon "Joonistus kui identiteet" 14. ja 15. VIII Narvas. Kuraator Elnara Taidre, korraldaja Aili Vahtrapuu. 15. VIII avati Narva muuseumi kunstigaleriis joonistuste näitus "Nulla Dies Sine Linea", toimus seminar. Narva-Jõesuus landart-likus liivajoonistusprojektis osalesid Narva kunstnikud ja EKA üliõpilased

Elektroonilise kunsti sümpoosion

Index Scriptorium Estoniae

2004-01-01

ISEA 2004 Tallinna näitused avatakse 17. VIII Rotermanni soolalaos, Tallinna Kunstihoones, Ku galeriis, Tallinna Linnagaleriis, Eesti Tarbekunsti- ja Disainimuuseumis, Elioni majas, Viru Keskuses, Eesti Kunstiakadeemias, Bon-Boni ööklubis, Multikultuurimajas. Loetletud osalejaid, toimuvad klubiõhtud, moedemonstratsioon, töötoad. 17. ja 18. VIII kinos "Kosmos" ja EKA-s toimuval konverentsil esinejaid. Programmi koordinaator Mare Tralla

Unest äratatud Alatskivi loss / Meeli Müüripeal, Sirje Pärismaa

Index Scriptorium Estoniae

Müüripeal, Meeli, 1963-

2005-01-01

Alatskivi lossist (Arved von Nolcken, 1880-1885), lossi restaureerimise käigust ja seisust. Korras on viis esindusruumi. Sisekujunduse autorid: Olev Suuder, Oleg Mellov, ARC Projekt. SA Alatskivi Loss plaanidest. Kommenteerivad sihtasutuse juhataja Külli Must, lossi taastamise eestvedajad restauraator Raivo Nisu ja senine vallavanem Maie Nisu, kes kaitses 2004. a. EKA-s magistritöö "Alatskivi mõisaansambli revitaliseerimise ideeprojekt". 14 ill

Tallinn on klaasikunsti päralt / Mare Saare, Maie-Ann Raun

Index Scriptorium Estoniae

Saare, Mare, 1955-

2001-01-01

Tallinna Kunstihoones Põhja- ja Baltimaade klaasikunsti rändnäitus "Nordic Glass 2000". EKA klaasiüliõpilaste tööde valiknäitus "Glass with care" EKA galeriis, III kursuse klaasiüliõpilaste tööde näitus tervishoiumuuseumis. Rahvusraamatukogu peanäitusesaalis eesti graveeritud klaasi näitus. Raekoja galeriis klaasinäitus "Lorupist Lorupini"

Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

Energy Technology Data Exchange (ETDEWEB)

Claesson, Kristina

2011-05-15

In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

Lõpetajad : Eesti Kunstiakadeemia

Index Scriptorium Estoniae

2001-01-01

Kunstiteadus - 4, maalikunst - 5, stsenograafia - 3, graafika - 9, skulptuur - 4, keraamika - 4, klaasikunst - 2, metallikunst - 8, tekstiil - 6, moekunst - 2, nahakunst - 3, sisearhitektuur - 10, graafiline disain - 6, tootedisain - 8, arhitektuur (kutsemagistri kraad) - 24; magistriõpe: kunst: 4, kunstiteadus - 3. EKA Avatud Akadeemia: kujunduskunst - 17, graafiline disain - 5, tootedisain - 3. EKA Rakenduskunsti Kolledzh: graafiline disain - 4, tootedisain - 12, tekstiil ja mood - 5, ikoonimaal ja restaureerimine - 4.

"Rindemehed" Tallinna Kunstihoones

Index Scriptorium Estoniae

2004-01-01

7. XI avatakse Tallinna Kunstihoones ja Kunstihoone galeriis Ilya ja Emilia Kabakovi ning Raul Meele näitus, Tallinna Linnagaleriis New Yorgis Kabakovi ateljees töötanud Villu Plingi ja Jan Bergi näitus. 8. XI Eesti Kunstiakadeemias toimuval EKA nõukogu avalikul koosolekul promoveeritakse EKA 85. aastapäeval audoktoriks Ilya Kabakov, kes peab pärast tseremooniat akadeemilise loengu. Repliik Ilya Kabakovilt ja Raul Meelelt

Radiohalogenation of biomolecules. An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution

International Nuclear Information System (INIS)

Koziorowski, J.

1998-01-01

Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging, and in radionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. The focus is on 211 At and 124 I, the former being a candidate for nuclide therapy and the latter potentially useful for diagnostic imaging and Auger-electron based radiotherapy. For astatine the separation, labeling and some biological behavior is described, and for iodine the latter two. Astatine was separated from an irradiated bismuth target by dry distillation. A novel cryotrap was developed for the isolation of astatine and subsequent synthesis of radiolabeled compounds. 5-[ 211 At]astato-2'-deoxyuridine (AUdR) and N-succinimidyl-4-[ 211 At]astatobenzoate (SAB) were synthesized in 95% respectively 90% radiochemical yields. The former is incorporated into DNA of proliferating cells and can therefore be used as an endoradiotherapeutic agent. The latter is a conjugate for the astatination of proteins. Human epidermal growth factor (hEGF) was tagged with astatine using three approaches: a) direct labeling of native hEGF, b) conjugation with SAB, and c) direct labeling of an hEGF - 7-(3-aminopropyl)-7,8-dicarba-nido-undecaborate(1-) conjugate. The overall labeling yields were 3.5% for direct labeling, 44% for SAB and 70% for the hEGF-nido-carborane conjugate. A new route to N-succinimidyl 3- and 4- [ 124 I]iodobenzoate, two reagents for radioiodination of proteins is described affording 90% radiochemical yield. Three radioiodinated analogs of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxyam ide, a peripheral-type benzodiazepine receptor antagonist, were synthesized. All three analogs were obtained in >90% radiochemical yield. Synthesis and application of 5-[ 124 I]iodo-2'-deoxyuridine (IUdR) is presented. The closo-dodecaborate anion was evaluated as prosthetic group for radioiodination of

Ajalooliselt ebakorrektne Robert Baines / Robert Baines ; interv. Kadri Mälk

Index Scriptorium Estoniae

Baines, Robert

2004-01-01

Ajaloolist ehtekunsti erinevates muuseumides uurinud R. Baines pidas aprilli lõpul loengu EKAs ja viis läbi meistriklassi. R. Baines uurimistööst muuseumis, oma loomingust, galerii ja muuseumi vahekorrast, eesti ehtekunstist tarbekunsti- ja disainimuuseumis ja näitusel Ku galeriis (B. Lillemets, K. Maran), ehtekunstiõpetusest EKAs jm. R. Bainesi uurimustel põhinev näitus avati aprillis Müncheni antiigimuuseumis ja tema ehteloomingu näitus Biro galeriis

Evolution of microbial communities during electrokinetic treatment of antibiotic-polluted soil.

Science.gov (United States)

Li, Hongna; Li, Binxu; Zhang, Zhiguo; Zhu, Changxiong; Tian, Yunlong; Ye, Jing

2018-02-01

The evolution of microbial communities during the electrokinetic treatment of antibiotic-polluted soil (EKA) was investigated with chlortetracycline (CTC), oxytetracycline (OTC) and tetracycline (TC) as template antibiotics. The total population of soil microorganisms was less affected during the electrokinetic process, while living anti-CTC, anti-OTC, anti-TC and anti-MIX bacteria were inactivated by 10.48%, 31.37%, 34.76%, and 22.08%, respectively, during the 7-day treatment compared with antibiotic-polluted soil without an electric field (NOE). Accordingly, samples with NOE treatment showed a higher Shannon index than those with EKA treatment, indicating a reduction of the microbial community diversity after electrokinetic processes. The major taxonomic phyla found in the samples of EKA and NOE treatment were Proteobacteria, Bacteroidetes, Firmicutes and Actinobacteria. And the distribution of Actinobacteria, Cyanobacteria, and Chloroflexi was greatly decreased compared with blank soil. In the phylum Proteobacteria, the abundance of Alphaproteobacteria was greatly reduced in the soils supplemented with antibiotics (from 13.40% in blank soil to 6.43-10.16% after treatment); while Betaproteobacteria and Deltaproteobacteria showed a different trend with their abundance increased compared to blank soil, and Gammaproteobacteria remained unchanged for all treatments (2.36-2.78%). The varied trends for different classes indicated that the major bacterial groups changed with the treatments due to their different adaptability to the antibiotics as well as to the electric field. SulI being an exception, the reduction ratio of the observed antibiotic resistance genes (ARGs) including tetC, tetG, tetW, tetM, intI1, and sulII in the 0-2cm soil sampled with EKA versus NOE treatment reached 55.17%, 3.59%, 99.26%, 89.51%, 30.40%, and 27.92%, respectively. Finally, correlation analysis was conducted between antibiotic-resistant bacteria, ARGs and taxonomic bacterial classes. It

Sihtasutus Eesti Rahvuskultuuri Fond võtab 15. oktoobrini vastu...

Index Scriptorium Estoniae

2003-01-01

Võetakse vastu 2004. a. stipendiumide ja kultuuriprojektide finantseerimise taotlusi. Esimest korda määratakse 2003. a. stipendiume järgmistest nimelistest allfondidest: Arvo Nenni ja Ingrid Nenni (Nõges) Fond toetab EKMi eesti kunstipärandi ostmisel, Edmund Valtmani Fond toetab stipendiumiga EKA üliõpilast või alla 30-aastast EKA vilistlast parima graafilise teose eest, Natalie Mei Fond toetab professionaalsete ja tulemuslike lava- ning kostüümikujundajate tegevust ja täiendusõpet jt.

Relative abundance of PcP energy in explosion seismic signals from Eastern Kazakh and South Western Russia recorded at Eskdalemuir, Yellowknife and Gauribidanur arrays

International Nuclear Information System (INIS)

Basu, T.K.; Arora, S.K.

1991-01-01

In this study further evidence of relative abundance of PcP (core reflected P) energy in explosion seismic records is gathered. It is based on the analysis of temporal and spectral characteristics of P and PcP digital seismograms of twenty-three underground nuclear explosions in Eastern Kazakh and Southern Russia recorded at Eskdalemuir (EKA) and Yellowkinfe (YKA) arrays. The results are compared with those obtained earlier using Gauribidanur array (GBA) data. It is found that seismic sources in Southwestern Russia give consistently large values of the PcP identifier when both EKA and YKA data are used thus corroborating authors' earlier finding with regard to this Soviet region of typical Q-structure inferred from GBA data. As regards relative levels of PcP energy in explosion generated seismic waves, it is found to be substantially large at GBA, moderate at YKA and least at EKA. (author). 8 figs., 3 tabs

Tallinna Ülikool tulekul / Sirje Tohver

Index Scriptorium Estoniae

Tohver, Sirje

2002-01-01

Ajaloo Instituudi, EAR-i, Eesti Humanitaarinstituudi, EKA ja TPÜ juhid kirjutasid 15.05.2002 Tallinna Raekojas alla ühise tegevuse lepingule ning ühiste kavatsuste deklaratsioonile. Tallinna Ülikooli alustab 2003/04. õa. Kirjutati alla ka koostöölepingule Tallinna linnaga, mis sätestab lepingupoolte tegevuse urbanistikaalase õppetöö ning linnauuringute korraldamisel. Kommenteerivad TPÜ rektor M. Heidmets, EKA rektor A. Keskküla, Ajaloo Instituudi direktor P. Raudkivi, EHI Sihtasutuse Nõukogu esimees R. Raud, EHI rektor J. Tamm

"Nägemus" EKA galeriis

Index Scriptorium Estoniae

2003-01-01

Tartu Kõrgema Kunstikooli tekstiilikunsti osakonna gobeläänide näitus "Nägemus". Osalejad: Triinu Pungits, Signe Vilde, Jaanika Terasmaa, Leeda Ots, Gerli Aimla, Merike Uiga, Irina Vizner-Laur, Mari Vaaderpall, Heike Sepp

Fabergé fondi tunnustus Eesti ehtekunstile

Index Scriptorium Estoniae

2002-01-01

Mais Peterburis toimunud Fabergé fondi noorte ehtekunsti rahvusvahelisel konkurssnäitusel võitis nooremas vanuserühmas I preemia EKA sepakunsti üliõpilane Argo Männik, II-III preemiat jagas ehtekunsti magistrant Andrus Rumm. Mais oli EKA ehteväljapanek Genfis kaasaegse ehtekunsti suursündmusel "L' ornement est-il toujours un crime". Väljapanekud koostas Kadri Mälk. Genfi kunstimuuseumis šveitsi XX sajandi ehtekunsti erinäitus. Muuseum avaldas soovi võtta oma püsikogusse Eve Margus-Villemsi objekt "Enesepettus"

Uued raamatud

Index Scriptorium Estoniae

2005-01-01

Constructed happiness - domestic environment in the cold war era / Võistlevad õnned - elukeskkond külma sõja perioodil (EKA, 2005; toimetajad Mart Kalm, Ingrid Ruudi, kujundajad Martin Lazarev, Tiit Lepp, Andrus Kõresaar); Ruumipilt : Eesti parimad interjöörid ja disain : konkurss 2004 / Eesti Sisearhitektide Liit (Minuskel, 2005; projektijuht Mati Veermets, kujundaja Tiiu Prisko, tekstid: Ell-Maaja Randküla); Eesti Kunstiakadeemia ajakirja 1. number (toimetajad Karolin Kuusik, Kristina Paju, kujundajad Kadri-Maria Mitt, Tuuli Aule, fotod: Tatjana Muravskaja); Eesti Kunstiakadeemia lõputööd 2005 (EKA, 2005; koostajad Karin Laansoo, Alo Paistik, kujundajad T. Aule, K.-M. Mitt, fotograafid Pelle Kalmo, Riikka Tauriainen, Anu Vahtra); Hallas-Murula, Karin. Suurlinn Tallinn : Eliel Saarineni "Suur-Tallinna" projekt. 1913 (Eesti Arhitektuurimuuseum, 2005; kujundaja Tiit Jürna); Kivi, Raul-Levroit. Tartu planeerimisest ja arhitektuurist : artikleid ja mälestusi (Eesti Arhitektuurimuuseum, 2005; koostajad Jaan Malin, K. Hallas-Murula); Arhitektuuriaasta 2004 : arhitektuuripreemiate nominendid (Solnessi Arhitektuurikirjastus, 2005; tekst: Epp Lankots, kujundaja Arhitektuuri Domeen); Archiprix International 2005 : world's best graduation projects (Rotterdam, 2005; EKA lõpetanud arhitektidest on publitseeritud Ralf Lõokese magistritöö "Superrand")

Astatine-211 labeling. A study towards automatic production of astatinated antibodies

International Nuclear Information System (INIS)

Emma Aneheim; Per Albertsson; Sture Lindegren; Holger Jensen

2015-01-01

Targeted alpha therapy is especially interesting for therapy of microscopic cancer tumors due to short path length and high linear energy transfer of the alpha particles. One of the most promising nuclides for targeted alpha therapy is 211 At. To facilitate larger clinical studies using 211 At, the current manual synthesis of radiolabeled antibodies would benefit from being transferred into an automated method. In this work, successful modifications of the manual synthesis have been performed in order to adapt it to automation. The automatic synthesis has also been tested using the modified synthesis method. (author)

$\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

CERN Multimedia

We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

EKA tootedisaini üliõpilane...

Index Scriptorium Estoniae

2005-01-01

Eesti Kunstiakadeemia tootedisaini osakonna IV kursuse üliõpilane Riho Tiivel võitis Itaalias toimunud disainikonkursi "ReAL 13 - Eating Anywhere" peapreemia oma alumiiniumist lusikaga "Spoon Container"

2. XI esitles EKA aulas...

Index Scriptorium Estoniae

2005-01-01

Kunstidoktor Kärt Summatavet esitles oma raamatut "Folk Tradition and Artistic Inspiration. A Woman's Life in Traditional Estonian Jewelry and Crafts as Told by Anne and Roosi" ("Pärimus ja inspiratsioon. Kõnelusi Anne ja Roosiga naise elukaarest eesti pärimuslikus ehtekultuuris ning käsitöös". Raamat on Helsingi kunsti- ja disainiülikoolis kaitstud doktoritöö publikatsioon

11. X esitleti EKA raamatukogus...

Index Scriptorium Estoniae

2005-01-01

Esitleti artiklite kogumikku "Constructed Happiness. Domestic Environment in the Cold War Era/Võistlevad õnned. Elukeskkond külma sõja ajal", kuhu on koondatud 2004. a. kunstiteaduste instituudis peetud rahvusvahelise konverentsi materjalid

EKA e-meedia keskus korraldab...

Index Scriptorium Estoniae

2005-01-01

Adobe AfterEffects'i (algkursus 28.-31. III, 1. IV, registreerimine kuni 23. III, edasijõudnute kursus 22.-24. III, registreerimine kuni 18. III, juhendab Manuel Zadok Prantsusmaalt) ja Macromedia Flash'i (juhendab Raitis Smits Lätist) kursused

Rohelised koridorid: Raekoda maastikus = Green corridors: Town Hall in landscape / Kristiina Remmelkoor

Index Scriptorium Estoniae

Remmelkoor, Kristiina

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus, kus Admiraliteedi bassein koos uue raekojahoonega saavad osaks suurest avalikust pargist

Lävimine: aatrium kommunikatsiooni loojana = Interaction: atrium as generator of communication / Maie Raud, Anni Haldre

Index Scriptorium Estoniae

Raud, Maie

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus, kus aatrium on konstruktiivne, logistiline ja infovahetuse sõlmpunkt raekoja hoones

Sulandumine: brändimaastik = Blending in: brandscape / Artur Staškevitš

Index Scriptorium Estoniae

Staškevitš, Artur

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus koosneb kolmest selgest arhitektuursest ja ehituslikust mahust, mis sujuvalt linnakeskkonda sulanduvad

Eriilmeline Tallinn: identiteetide paljususe soodustamine = Diverse Tallinn: fostering diversity of identities / Alvin Järving, Marten Kaevats, Kadri Klementi...[jt.

Index Scriptorium Estoniae

2010-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna IV kursuse 2009-2010 õppeaastal uuritakse linnaehituslikke probleeme. Tallinna linna visioonidest. Iga linnaasum vajab omale tugevat identiteeti. Kodukant kui linnaruumi tasand

Ars longa vita brevis / Endrik Mänd

Index Scriptorium Estoniae

Mänd, Endrik, 1972-

2011-01-01

EKA uue hoone ehitusloa menetlemisega seotud pöördumisest Tallinna Linnaplaneerimise Ametile. Linn represseerivat kinnisvaraomanikku, sest viimane ei nõustu kooskõlastama Eesti Kunstiakadeemia ehitusluba

Väljak: esindusväljak = Square: the city square / Merilin Jürimets

Index Scriptorium Estoniae

Jürimets, Merilin

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus,kus strateegilises asukohas olev raekoda avab tänavapinna maksimaalselt avalikkusele

Täna kell 14 avatakse Eesti Kunstiakadeemias...

Index Scriptorium Estoniae

2002-01-01

Avatakse mälestustahvel (autor Mare Mikof) EKA keraamikaosakonna asutajale Géza Jak̤le. Janos Probstnerilt ettekanne G. Jak̤ tegevusest, ungari kaasegsest keraamikast ja Kecskemeti keraamikastuudiost

Sulandumine: jalajälg = Blending in: the footprint / Anni Haldre, Marilin Tuulemets

Index Scriptorium Estoniae

Haldre, Anni, 1990-

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus raekojale, kus vormimäärajaks sai olemasoleva krundi maksimaalne mahuline ärakasutamine

Admiraliteedi bassein: tühermaa = Admirality basin: wasteland / Kaisa Lillemets

Index Scriptorium Estoniae

Lillemets, Kaisa, 1986-

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodava raekoja asukohana valitud Admiraliteedi basseini äärse ümbruse kirjeldus Kaisa Lillemetsa planšetilt

Tavasti stipendium = Tavast scholarship

Index Scriptorium Estoniae

2014-01-01

Ennesõjaaegse Eesti tuntuima juveelitöösturi Roman Tavasti poja Raul-Roman Tavasti 1998. aastal asutatud stipendium professionaalse ehtekunsti järelkasvu toetamiseks EKA ehtekunsti eriala üliõpilastele

Väljak: siseväljak = Square: inner plaza / Kristi Tuurmann, Tiia Vahula, Riin Kersalu, Kerstin Kivila

Index Scriptorium Estoniae

Tuurmann, Kristi

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus, kus ei teki raekoja ette traditsioonilist väljakut, pigem "kolib" see avaliku ruumina linnavalitsuse sisse

An Expert System for Managing Storage Space Constraints Aboard United States Naval Vessels

Science.gov (United States)

1991-12-01

d. solvents, thinners, primers, cmpounds, varnishes , and lacquers i e. alcohol, acetone, ether, and naphtha; f. greases * nd pastes Except for...suffocation. Malocarbon liquids are compounds of carbon containing any of the halogen elements ( fluorine , chlorine, bromine, iodine, or astatine. (Examples are

Aed: ajastatud = Garden: timed / Eve Komp

Index Scriptorium Estoniae

Komp, Eve, 1982-

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahenduses on iga avalik ruum ümber raekoja hoone kujundatud erinevalt, vastavalt päeva rütmile

Väljak: satelliitväljakud = Square: satellite squares / Siim Tiisvelt

Index Scriptorium Estoniae

Tiisvelt, SIim, 1987-

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus, kus uue raekoja linnaehituslik idee lähtub antud piirkonnas ruumiliselt kõige domineerivamast elemendist - Admiraliteedi basseinist

Reprogramming of rabbit induced pluripotent stem cells toward epiblast and chimeric competency using Krüppel-like factors

Directory of Open Access Journals (Sweden)

Yann Tapponnier

2017-10-01

Full Text Available Rabbit induced pluripotent stem cells (rbiPSCs possess the characteristic features of primed pluripotency as defined in rodents and primates. In the present study, we reprogrammed rbiPSCs using human Krüppel-like factors (KLFs 2 and 4 and cultured them in a medium supplemented with fetal calf serum and leukemia inhibitory factor. These cells (designated rbEKA were propagated by enzymatic dissociation for at least 30 passages, during which they maintained a normal karyotype. This new culturing protocol resulted in transcriptional and epigenetic reconfiguration, as substantiated by the expression of transcription factors and the presence of histone modifications associated with naïve pluripotency. Furthermore, microarray analysis of rbiPSCs, rbEKA cells, rabbit ICM cells, and rabbit epiblast showed that the global gene expression profile of the reprogrammed rbiPSCs was more similar to that of rabbit ICM and epiblast cells. Injection of rbEKA cells into 8-cell stage rabbit embryos resulted in extensive colonization of ICM in 9% early-blastocysts (E3.5, epiblast in 10% mid-blastocysts (E4.5, and embryonic disk in 1.4% pre-gastrulae (E6. Thus, these results indicate that KLF2 and KLF4 triggered the conversion of rbiPSCs into epiblast-like, embryo colonization-competent PSCs. Our results highlight some of the requirements to achieve bona fide chimeric competency.

Rohelised koridorid: vöö = Green corridors: the belt / Kaisa Lillemets

Index Scriptorium Estoniae

Lillemets, Kaisa, 1986-

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahenduse põhiideeks on kaks teistest eristuvat hoonet (raekoda ja sadam), mis ühendavad basseini ja rohevöö

Kas sent või sant? / Riin Kübarsepp

Index Scriptorium Estoniae

Kübarsepp, Riin, 1978-

2000-01-01

Silja Saarepuu näitusest "Sent" Tallinna Linnagaleriis, kerjuste piltidest Von Krahli teari akendel ja kerjuste kujutistega plakatitest reklaamtulpadel. Võrdluseks EKA graafikatudengi Elisabeth Salmini grafititest sõnumiga "Sa oled aus, tark ja seksikas".

Struktuur eri pikkusskaaladel = Structure on different length-scales / Salmaan Craig, Martin Melioranski

Index Scriptorium Estoniae

Craig, Salmaan

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonnaõppejõu Martin Melioranski vestluskaaslane Salmaan Craig on Harvard Graduate School of Design külalislektor ja töötab ühtlasi arhitektuuribüroos Foster + Partners

Sadama ala planeering = Harbour area master plan / Ivan Sergejev, Helen Rebane, Karina Niinepuu

Index Scriptorium Estoniae

Sergejev, Ivan, 1987-

2010-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna IV kursuse 2009-2010 õppeaastal erialase projekteerimise raames kavandatud planeeringu eesmärgiks on tihendada Tallinna sadama ala ning arendada sellest välja mitmekesine ja efektiivne linnaruum

A contribution to the search for the element 114 in nature

International Nuclear Information System (INIS)

McMinn, J.

1975-09-01

Starting from a lead ore having an age of 1.3 x 10 9 years, an already chemically pre-enriched material up to a factor of about 2 to 3 x 10 8 was available for the search of the element 114 based on the properties predicted for eka lead. A further physical enrichment was undertaken using the Juelich high performance electromagnetic isotope separator. The exposed target material (synthetic quartz glass plates)in the mass range 278 to 290 in the mass separator was irradiated with thermal neutrons and the fission tracks were counted under an optical microscope. The background due to fissionable impurities in the quartz ( -13 atoms per SiO 2 molecule) and that due to the use of the mass separator were studied in preliminary experiments. The possible escape of the presumably volatile element 114 from the fission track detectors during irradiation as a result of nuclear γ-heating was also investigated in simulation experiments. The diffusion behaviour of carrier-free 203 Hg implanted into quartz plates in the mass separator, as determined by a radiometric analysis, showed that the expected losses are negligible below 200 0 C. The counting results from the fission track detectors gave a maximum value of 5.1 x 10 -22 barns for the product of the fission cross section sigmasub(f) and the number of eka-lead atoms per lead carrier atom. In order to be able to make an estimate of the absolute concentration limits, the fission cross sections of eka-lead for thermal neutrons were approximated using an extrapolation method. Assuming these approximate fission cross sections, the absolute concentration limits of 8 x 10sup(-24), 3 x 10 -22 and 1 x 10 -19 share of eka-lead atoms per carrier atom were obtained for the isotopes 295, 297 and 298 (sigma = 70 barns, 2 barns and 4 gbarns). (orig./LH) [de

SISU sümpoosion Ruumimõju = The Impact of Space / Tüüne-Kristin Vaikla

Index Scriptorium Estoniae

Vaikla, Tüüne-Kristin, 1961-

2015-01-01

Eesti Sisearhitektide Liit koos EKA sisearhitektuuri osakonnaga korraldas 27.-30. mail Tallinnas rahvusvahelise sümpoosioni "Sisu. Ruumimõju / The Impact of Space, kus kohtusid sisearhitektuuri valdkonna tunnustatud teoreetikud ja praktikud üle maailma

EKA urbanistika osakond / Lilia del Rio

Index Scriptorium Estoniae

Rio, Lilia del

2006-01-01

Lilia del Rio magistritöö "Beyond the player's manual / Mänguõpetus edasijõudnutele. Experiencing the world (and the city) as a playground / Kogedes maailma (ja linna) mänguväljakuna". Juhendaja Andres Kurg

6.-15. X on EKA galeriis...

Index Scriptorium Estoniae

2003-01-01

Keraamika eriala magistrantide näitus "Argilla neljale". Eksponeeritakse Reeli Haameri, Kadri Kivi, Annika Vilippuse ja Matthew Graziano magistriõppe meistriklassi raames valminud töid koos tehnikaid tutvustavate tekstidega

Community lab kunstihoones ja Arsenales / Harry Liivrand

Index Scriptorium Estoniae

Liivrand, Harry, 1961-

2003-01-01

Taani kaasaegse kunsti näitus "Projekt" Tallinna Kunstihoones, kus osalevad EKA üliõpilased ja külalised Lätist. Kuraatorite Molly Nesbiti, Hans Ulrich Obristi ja Rirkrit Tiravanija projekt "Utopia Station" Veneetsia biennaalil

Väikeste asjade kunst - The Art of Small Things / Martin Pärn

Index Scriptorium Estoniae

Pärn, Martin, 1971-

2003-01-01

Uued liinid disainihariduses, EKA tootedisaini osakonna osalemine viie kooli vahelises SPARK!- programmis, tavalise disaini roll (Väikeste Asjade Tegemise Kunst). Kompaktsuse positiivne näide - 1859. a. Thonet' loodud tool nr. 14. Õnnestunud disain

Tudengipreemia 2012 = Student award 2012

Index Scriptorium Estoniae

2013-01-01

Eesti Sisearhitektide Liidu 2012. aasta tudengipreemia pälvis Eesti Kunstiakadeemia sisearhitektuuri ja mööblidisaini üliõpilane Ivo Rannaste. EKA professor, sisearhitektuuri ja mööblidisaini osakonna juhataja Toivo Raidmets Ivo Rannastest

Eesti noordisainerid rahvusvahelises koguteoses

Index Scriptorium Estoniae

2000-01-01

"Graphise" koguteoses "New Talent Design Annual 2000" on esindatud Eesti Kunstiakadeemia graafilise disaini üliõpilased (nüüdseks EKA lõpetanud) Taavi Torim (illustratsioon) ja Maris Lindoja (kaks postmargikavandit). Juhendajaks oli Jüri Hain

V poiskah garmonii / Rafael Danieljants ; interv. Tamara Unanova

Index Scriptorium Estoniae

Danieljants, Rafael

2000-01-01

Armeenia päritolu skulptor Rafael Danieljants (EKA, 1984) oma töödest, õpetajatööst Maardu kunstikoolis jm. Viimane tema tööde näitus oli Armeenia kultuurikeskuses Tallinnas : eksponeeriti armeeniateemalisi skulptuure

Rohelised koridorid: kanal = Green corridors: canal / Kristel Niisuke

Index Scriptorium Estoniae

Niisuke, Kristel

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud töö keskseks ruumiliseks ideeks on Admiraliteedi basseini põhjakülge merega ühendav kanal ja selle kõrval kulgev promenaad

Aed: kaldapealne = Garden: the waterfront / Eva Kedelauk, Maie Raud

Index Scriptorium Estoniae

Kedelauk, Eva

2013-01-01

EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus, kus Admiraliteedi basseini kaldal kulgeva promenaadi linna suunas deformeerumine loob raekoja ja projekt pakub välja linnaehitusliku tiheduse jätkamise

Charge radii and electromagnetic moments of At-211195

Science.gov (United States)

Cubiss, J. G.; Barzakh, A. E.; Seliverstov, M. D.; Andreyev, A. N.; Andel, B.; Antalic, S.; Ascher, P.; Atanasov, D.; Beck, D.; Bieroń, J.; Blaum, K.; Borgmann, Ch.; Breitenfeldt, M.; Capponi, L.; Cocolios, T. E.; Day Goodacre, T.; Derkx, X.; De Witte, H.; Elseviers, J.; Fedorov, D. V.; Fedosseev, V. N.; Fritzsche, S.; Gaffney, L. P.; George, S.; Ghys, L.; Heßberger, F. P.; Huyse, M.; Imai, N.; Kalaninová, Z.; Kisler, D.; Köster, U.; Kowalska, M.; Kreim, S.; Lane, J. F. W.; Liberati, V.; Lunney, D.; Lynch, K. M.; Manea, V.; Marsh, B. A.; Mitsuoka, S.; Molkanov, P. L.; Nagame, Y.; Neidherr, D.; Nishio, K.; Ota, S.; Pauwels, D.; Popescu, L.; Radulov, D.; Rapisarda, E.; Revill, J. P.; Rosenbusch, M.; Rossel, R. E.; Rothe, S.; Sandhu, K.; Schweikhard, L.; Sels, S.; Truesdale, V. L.; Van Beveren, C.; Van den Bergh, P.; Wakabayashi, Y.; Van Duppen, P.; Wendt, K. D. A.; Wienholtz, F.; Whitmore, B. W.; Wilson, G. L.; Wolf, R. N.; Zuber, K.

2018-05-01

Hyperfine-structure parameters and isotope shifts of At-211195 have been measured for the first time at CERN-ISOLDE, using the in-source resonance-ionization spectroscopy method. The hyperfine structures of isotopes were recorded using a triad of experimental techniques for monitoring the photo-ion current. The Multi-Reflection Time-of-Flight Mass Spectrometer, in connection with a high-resolution electron multiplier, was used as an ion-counting setup for isotopes that either were affected by strong isobaric contamination or possessed a long half-life; the ISOLDE Faraday cups were used for cases with high-intensity beams; and the Windmill decay station was used for short-lived, predominantly α -decaying nuclei. The electromagnetic moments and changes in the mean-square charge radii of the astatine nuclei have been extracted from the measured hyperfine-structure constants and isotope shifts. This was only made possible by dedicated state-of-the-art large-scale atomic computations of the electronic factors and the specific mass shift of atomic transitions in astatine that are needed for these extractions. By comparison with systematics, it was possible to assess the reliability of the results of these calculations and their ascribed uncertainties. A strong deviation in the ground-state mean-square charge radii of the lightest astatine isotopes, from the trend of the (spherical) lead isotopes, is interpreted as the result of an onset of deformation. This behavior bears a resemblance to the deviation observed in the isotonic polonium isotopes. Cases for shape coexistence have been identified in At,199197, for which a significant difference in the charge radii for ground (9 /2- ) and isomeric (1 /2+ ) states has been observed.

Rae planeering: Rae talu / Eerika Alev

Index Scriptorium Estoniae

Alev, Eerika

2013-01-01

EKA arhitektuuri ja linnaplaneerimise IV kursuse üliõpilaste 2011- 2012 õppeaastal loodud Rae küla planeeringus on aktivaatori roll talul, mis pakub tööd ja elukohta nii peredele kui hooaja töölistele.

Rae planeering: 2x Rae / Eerika Alev, Kaisa Lillemets, Siim Tiisvelt

Index Scriptorium Estoniae

Alev, Eerika

2013-01-01

EKA arhitektuuri ja linnaplaneerimise IV kursuse üliõpilaste 2011- 2012 õppeaastal loodud planeeringu eesmärk oli säilitada Rae küla senine valglinnastunud struktuur ja panna see toimima ka tõelise külana.

Ehitusmaailma stipendiumid / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2001-01-01

Ehitusmaailma kaupluseketi omanik AS "Fanaal" jagas kolmandat korda välja stipendiumid ehitus-, arhitektuuri- ja restaureerimisala üliõpilastele. Stipendiumi said: Mati Raal (EKA), Andrus Räämet, Eero Tuhkanen (TTÜ), Priit Lõhmus, Mauro Ilves, Maidu Saar (EPÜ)

F(akt)

Index Scriptorium Estoniae

2009-01-01

EKA tudengite Johannes Säre, Taaniel Raudsepa, Karel Koplimetsa, Sigrid Viiru fotode näitus Eesti Kunstiakadeemia galeriis 14.01.-23.01.2009. Juhendaja Tanja Muravskaja. Näitusel eksponeeritud töödest, nende valmimisest vestlevad fotode autorid

Meedialabor Tallinnas / Sirje Helme

Index Scriptorium Estoniae

Helme, Sirje, 1949-

2001-01-01

KKEK aastanäitus "Interstanding 4" alapealkirjaga "end repeat" Rotermanni soolalaos. "Interstanding" on valminud koostöös EKA-ga Ando Keskküla initsiatiivil. "Interstanding 4" programmi "end repeat" autor Mare Tralla. Medialabist. Konverentsi kava lk. 21.

Vaikus moefotograafias / Kristina Paju

Index Scriptorium Estoniae

Paju, Kristina

2007-01-01

EKA moemagistrandi Kristina Paju ja fotograafide Anna-Stina Treumundi ning Kaisa Eiche näitusest "Vaikus moefotograafias", mille eesmärgiks on kirjeldada võimalusi, millised võiksid olla vaikuse eri aspektid, ka moefotograafias, toetudes Jean Baudrillardi teooriale

24. V avati Vaalas...

Index Scriptorium Estoniae

2005-01-01

Rumeenia kunstniku Calin Dani näitus "Emotional architecture 2. Lost in transition", mis põhineb postsotsialistlike linnade Bukaresti ja Tallinna võrdlusel, esitleb kunstniku veel protsessis olevat tööd, milles osalesid ka EKA üliõpilased

Kunstiakadeemia disainikonverents

Index Scriptorium Estoniae

2003-01-01

8.-10. V Rotermanni soolalaos ja Eesti Kunstiakadeemias rahvusvaheline disainikonverents "VALID : VALue in Design", mille korraldab EKA koostöös rahvusvahelise kunsti-, disaini- ja arhitektuurikõrgkoolide assotsiatsiooniga CUMULUS. Peaesinejad Diana Crane, Natasha Vita-More (USA), Carlo Vezzoli (Itaalia)

Westwoodi lakk-king Tallinnas

Index Scriptorium Estoniae

2002-01-01

Tallinna Kunstihoone galeriis ja Linnagaleriis briti moekunstnike aksessuaaride - peakatted, jalanõud, kotid - näitus "Satellites of Fashion", mis avati Jaanus Orgusaare rõiva- ja aksessuaari-showga. Mai algul viib nahkaksessuaaride disainer Paul Thomas läbi seminarid ja workshopid EKAs

Kunstnikuks pürgija vajab paari õigeaegset impulssi / Kaido Ole, Eva Unt

Index Scriptorium Estoniae

Ole, Kaido

2006-01-01

Antonia Claudio Carvalho meistriklass "Ava oma silmad/Open Your Eyes" 23.-27. I ja näitus 27. I-9. II Eesti Kunstiakadeemia galeriis. Meistriklassist vestlesid EKA maaliosakonna juhataja Kaido Ole ja maalieriala III kursuse üliõpilane Eva Unt

Maastikuarhitektuuri koolitusest Eesti Kunstiakadeemias = Schooling in Landscape Architecture at the Estonian Academy of Art / Katrin Koov

Index Scriptorium Estoniae

Koov, Katrin, 1973-

2003-01-01

Maastikukool tegutseb EKA arhitektuuriosakonna juures neljandat hooaega. Seni oli tegemist valikkursusega, 2003/2004. õppeaastast on see lülitatud arhitektuuriüliõpilaste põhiõppesse. Maastikukooli eesmärgist ja plaanidest, ülevaade aastatel 2000-2003 toimunud maastikukoolidest. 6 ill

Jiri Shibori konstruktivistlik kujundimaailm / Eilve Manglus

Index Scriptorium Estoniae

Manglus, Eilve, 1977-

2004-01-01

Metallide tehnoloogiat õppinud Jiri Shibori näitus "Ehtekunsti ja skulptuuri vahel" Deco galeriis kuni 10. IV. Personaalnäitus toimub EKA ehte- ja sepakunsti osakonna kutsel, et viia läbi külmkinnituslike konstruktsioonidega metallitöö workshop

Kõrgkoolidesse saab astuda internetis / Tarmu Kurm

Index Scriptorium Estoniae

Kurm, Tarmu

2006-01-01

Sel aastal kasutavad ühist sisseastumise infosüsteemi SAIS Audentese Ülikool, EBS, Kaitseväe Ühendatud Õppeasutused, TLÜ, Eesti Infotehnoloogia Kolledž, TTÜ, EKA, Tartu Tervishoiu Kõrgkool, TÜ, EMÜ, Tallinna Tervishoiu Kõrgkool ja Eesti-Ameerika Äriakadeemia

Workshop on selected aspects of radiochemistry

International Nuclear Information System (INIS)

1991-11-01

The aspects chosen for the workshop are: isotope preparation, separation methods; radiochemical methods and analyses; environmental protection and radiochemistry; the chemistry of the fifth halogen, astatine. From the 28 contributions presented at the workshop, 24 are of relevance in the INIS and EDB scope and are separately retrievable from the database. (BBR) [de

Prantslased otsisid eestlaste juurest virmalisi / Henry Schmidt

Index Scriptorium Estoniae

Schmidt, Henry

2002-01-01

XI Põhjamaade kultuurifestival "Les Boréales" Prantsusmaal Caenis kutsus peakülaliseks Eesti. Eesti kunsti esindanud Raivo Kelomees Tartu Kõrgema Kunstikooli ja Jaan Toomik EKA üliõpilastega näitasid oma videokunsti, Liina Siibi näitus oli Alam-Normandia kunstikeskuses

Hulgi asju, mis asja? / Anneli Porri, Triin Männik

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2003-01-01

Briti seeriadisaini näitus "Multiplication" Tallinna raekojas 10. I-16. II. Mitmiklus kunstis.12. II pidas John Frankland loengu EKAs, 13. II osales Tallinna Kunstihoones diskussioonis briti 1990ndate kunsti üle, 14. II viis läbi workshopi Tallinna raekojas

7. I kell 18 avatakse Pärnu Muuseumi Aidas...

Index Scriptorium Estoniae

2006-01-01

Urmas Viigi juhendatud EKA graafikaüliõpilaste tööde näitus, toimuvad ka Pink Pungi, Ernest Truely, Lexxxa, Ville-Karel Viirelaiu, Egle Veske, Remo Randveri, Toomas Kuusingu, Meeland Sepa, Sorge, Sirami (Mari Kartau), Billeneeve, Tanel Saare performance'id

Avastatud klaas / Kai Lobjakas

Index Scriptorium Estoniae

Lobjakas, Kai, 1975-

2006-01-01

Euroopa kõrgkoolide klaasieriala üliõpilaste tööde näitus "Discovery / Avastusretk" Kullo galeriis kuni 19. V. Rahvusvahelise ürituse korraldajaks oli EKA klaasikunsti osakond eesotsas Mare Saare ja Tiina Sarapuga. Pikemalt Ave Maseri tööst "Maandumine"

Viru tunnel saab uue ilme urbanistliku grafiti abil / Ilmar Kahro

Index Scriptorium Estoniae

Kahro, Ilmar

2011-01-01

MTÜ Linnalabor koostöös Tallinn 2011 SA-ga viis läbi Tallinnas Gonsiori ja Laikmaa tänava ristmiku all paikneva Viru tunneli kujunduskonkursi "Viru tunnel kunstigaleriiks". EKA skulptuuri eriala tudengi Eldar Jakubovi võidutööst "Avame linna"

SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

Energy Technology Data Exchange (ETDEWEB)

Jaszczak, R.J.

1995-12-01

Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

International Nuclear Information System (INIS)

Jaszczak, R.J.

1995-12-01

Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

Disain+juhtimine : disainjuhtimise peaauhind Eestisse / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2012-01-01

Ühe 2012. a. Euroopa disainjuhtimise auhinna DME peaauhindadest sai Tallinna Transpordiameti uuendusprotsess kommunikatsiooni ja teenuse parandamiseks. Võidu taga on EKA tudengid Kristi Rummel, Brit Pavelson, Norman Orro ja Ronald Pihlapson, kes tegid seda alguses graafilise disaini osakonna 3. kursuse semestritööna

Teekann - keraamiku proovikivi

Index Scriptorium Estoniae

2001-01-01

Tallinna Linnagaleriis teekannude näitus "Time for Tea", mis annab ülevaate originaal- (Bernard Leachi koolkonna keraamikute tööd jm.) ja tööstusliku keraamika arengust Suurbritannias 20. sajandil. Kaasaegset keraamikat esindava Kate Malone'i workshop EKA keraamikaosakonnas 16.-19. IV.

Piero Castiglioni - praktilise ilu looja / Karin Paulus

Index Scriptorium Estoniae

Paulus, Karin, 1975-

2005-01-01

Itaalia disaineritest Castiglioni'dest, pikemalt Piero Castiglionist (sünd. 1944), kes külastas 2005. aasta märtsis Eestit. Loetletud tema tähtsamad tööd. Kommenteerivad sisearhitekt Hannes Praks, sisearhitekt Juta Lember, valgusdisainer Tarmo Luisk ja EKA professor Toivo Raidmets

Nahast väljunud V.A.V.A. / Lii Pihl

Index Scriptorium Estoniae

Pihl, Lii

2003-01-01

EKA nahakunsti eriala üliõpilastest ja vilistlastest koosneva rühmituse V.A.V.A. (välja arvatud ja väga austatud) installatsiooninäitus "Nihe" (alapealkiri "21. sajandi köiteväljund") Kuressaare linnuses kuni 14. IX. Kuraator Reet Viira

Kõrgkoolidesse saab astuda Internetis / Liivia Mahlapuu

Index Scriptorium Estoniae

Mahlapuu, Liivia

2006-01-01

Käesoleval aastal kasutavad veebipõhist infosüsteemi SAIS tudengite vastuvõtmisel Audentese Ülikool, EBS, Kaitseväe Ühendatud Õppeasutused, TLÜ, Eesti Infotehnoloogia Kolledž, TTÜ, EKA, Tartu Tervishoiu Kõrgkool, TÜ, EMÜ, Tallinna Tervishoiu Kõrgkool ja Eesti-Ameerika Äriakadeemia

Täna kell 20 esitletakse EKA galerii...

Index Scriptorium Estoniae

2004-01-01

Esitletakse norra kunstnike (loetletud) videosid "Darling, don't leave me all by myself". Korraldaja Bergeni kuraatoriduo Rakett (Asa Lövgren, Karolin Tampere). 4. IV näeb Tallinna projekti Von Krahli teatris

15. XI kell 17 avatakse EKA galeriis...

Index Scriptorium Estoniae

2004-01-01

Näitus "ERKI moe-show" 10 aastat", mille koostasid Karolin Kuusik, Gerli Liivamägi, Kristina Paju, Külli-Kerttu Siplane ja Agne Talu. Eksponeeritakse ka Jaanus Orgusaare, Vassilissa, Aldo Järvsoo ning Hula noortekollektsiooni esinemiste meeldejäävamaid hetki. 20. XI kinos Kosmos ERKI moeetendus "Go". Lavastuse autorid Taavet Jansen ja Oksana Titova, kunstiline juht Ain Nurmela, videokunstnik Taavi Warm, graafiline kujundus Martin Eelmalt, helikujundus Remi Prualilt

9. VI avati Deco galeriis...

Index Scriptorium Estoniae

2004-01-01

EKA graafikaosakonna magistrandi Anna Arho magistritööd tutvustav näitus "Still Life with Mothers and Daughters". A. Arho kaitses samas oma magistritöö, mille teooriaosas "Külalisena Graafikamaal" on vaatluse alla võetud eesti ja soome vabagraafika tänapäev

Nukufilm, mis pani kihama kogu Soome / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2008-01-01

Nukufilm "Uurali liblikas" (peategelaseks marssal Mannerheim) : režissöör Katariina Lillqvist : Soome 2008. Filmi esitleb Tallinnas K. Lillqvist uuel sariüritusel Animateek, mille taga seisavad festival Animated Dreams, EKA ja Kumu auditoorium. Lisatud andmed režissööri ja Animateegi kohta

Materjalid muudavad maailma = Materials change the world / Jaak Kikas

Index Scriptorium Estoniae

Kikas, Jaak

2005-01-01

Jaak Kikas TÜ materjaliteaduse instituudist mõnedest olulistest tendentsidest ja suundumustest uute materjalide otsingutel ning nendega kaasnevatest probleemidest. Materjaliteaduse artikli kommentaariks tutvustavad Kalle Komissarov (intervjueerija) ja Martin Pärn EKA disaini- ja tekstiilikateedri projekti "Arukate toodete disain - tuleviku eriala", millele saadi toetust SA Innove europrojektide raames

Kuni 24. XII on Y-galerii P- ja T-saalis vaadata näitus "Võõras mure"...

Index Scriptorium Estoniae

2005-01-01

Näitusel "Võõras mure" on väljas EKA avatud akadeemia lõpetanud kunstnike Anniki Kari, Ellen-Reet Türi ja Ulvi Kuldkepi maalid. A- ja E-saalis avatud Lauri Pajose näitusel "Tonal" näeb suuremõõtmelisi sürreaalabstraktseid maale

Chemical experiments with superheavy elements.

Science.gov (United States)

Türler, Andreas

2010-01-01

Unnoticed by many chemists, the Periodic Table of the Elements has been extended significantly in the last couple of years and the 7th period has very recently been completed with eka-Rn (element 118) currently being the heaviest element whose synthesis has been reported. These 'superheavy' elements (also called transactinides with atomic number > or = 104 (Rf)) have been artificially synthesized in fusion reactions at accelerators in minute quantities of a few single atoms. In addition, all isotopes of the transactinide elements are radioactive and decay with rather short half-lives. Nevertheless, it has been possible in some cases to investigate experimentally chemical properties of transactinide elements and even synthesize simple compounds. The experimental investigation of superheavy elements is especially intriguing, since theoretical calculations predict significant deviations from periodic trends due to the influence of strong relativistic effects. In this contribution first experiments with hassium (Hs, atomic number 108), copernicium (Cn, atomic number 112) and element 114 (eka-Pb) are reviewed.

Narva-teemaline magistritöö Pariisis / Merike Trubert

Index Scriptorium Estoniae

Trubert, Merike

2002-01-01

27. XI kaitsesid prantsuse arhitektuuriüliõpilased David Trubert ja Guillaume Blanchard (1999-2001 vahetusüliõpilased EKAs) Pariisi arhitektuurikoolis (Ecole d'Architecture de Paris Val-de-Seine) Narva linnaplaneeringut käsitleva magistritöö "Narva. Urban planning for social approach". Kaitsmiskomisjoni juhataja Mart Kalm

Urmo Raus : "Maalimine on mäluline protsess" / Urmo Raus ; interv. Reet Varblane

Index Scriptorium Estoniae

Raus, Urmo, 1969-

2003-01-01

Tallinna Kunstihoones Urmo Rausi maalinäituse avamise puhul intervjuu kunstnikuga, kes on õppinud Eesti Kunstiakadeemias, Pariisi Ecole Nationale Superieure des Beaux-Arts'is, on teinud näitusi Prantsusmaal, Itaalias, Venemaal, Eestis, elab Haagis. U. Raus kunstiõpetusest Pariisis ja EKA maaliosakonnas, kaasaegsest vitraažikunstist, oma maalikunstist

Tagasiviitavad tõendid: teine pilk pilditeadusele / Beat Wyss ; intervjueerinud Ivar-Kristjan Hein

Index Scriptorium Estoniae

Wyss, Beat, 1947-

2011-01-01

Intervjuus Karlsruhe kunsti- ja disainiülikooli kunstiajaloo ja meediateooria professori Beat Wyssiga on teemaks Zürichis tema juhitav uurimisprojekt, mille keskmes on Venezia biennaal Ida-Euroopa riikide positsioonilt, tema EKA Kunstiteaduse Instituudi doktorantidele peetud seminar "Tagasiviitavad tõendid. Teine pilk pilditeadusele", tema kaasaegse kunsti universaalsed põhimõtted

Lineaarse kunstiajaloo aeg on otsas / Edit András ; intervjueerinud R[eet] V[arblane

Index Scriptorium Estoniae

András, Edit

2010-01-01

Vestlus ungari kunstiteoreetiku- ja ajaloolase Edit Andrásiga, kes osales Tallinnas USA Clarki instituudi ja EKA Kunstiteaduste Instituudi seminaril, kus arutati Kesk- ja Ida-Euroopa kunstiajaloo kirjutamisviiside üle. Seminari tekkimisest, kokkusaamise põhjustest, seminari järeldustest, Eesti ja Ungari kunstiajaloo kirjutamise erinevatest põhimõtetest jm.

27. V kell 16 avatakse Niguliste kirikus...

Index Scriptorium Estoniae

2002-01-01

EKA interdistsiplinaarsete kunstide eriala magistritööde näitus "Nagu aamen kirikus". Eksponeeritud Kristin Kalamehe lühimängufilm "Igavene tuli", Mirja-Mari Smidti video ja maaliseeria "Kaaluta olek", Allan Tõnissoo videoskulptuur "Kristus", Avangardi (Sandra Jõgeva, Margus Tamm) fotoseeria ja video "Sõda ja rahu". Avamisel Avangardi performance

Taani-Eesti disaini ühisprojekt / Toivo Raidmets, Morten Lund

Index Scriptorium Estoniae

Raidmets, Toivo, 1955-

1998-01-01

14.-25. sept.-ni Tallinnas näituse "Elava disaini dialoog" raames EKA sisearhitektuuri osakonna ja Taani Disaini Kooli üliõpilaste workshop Tallinna Vineeri- ja Mööblikombinaadis. Valminud töid eksponeeritakse 25.-29. sept.-ni EestiKunstiakadeemia galeriis. Näitus ja workshop kuuluvad Taani Kultuuriinstituudi programmi "Baltimaade naasmine".

Värske kunsti paraad / Karin Laansoo

Index Scriptorium Estoniae

Laansoo, Karin, 1976-

2003-01-01

30. V-8. VI Rotermanni soolalaos näitus "Eesti Kunstiakadeemia lõputööd 2003", mille on kujundanud Oliver Soomets ja Kaiko Kivi. Trükised on kujundanud Maya Zerebtsova. 6. VI moeetendus. Academia Grata lõpetajate teoseid esitletakse Pärnus, meediagraafika lõputöid kaitstakse 11. VI EKA aulas

The Installation Restoration Program Toxicology Guide. Volume 2

Science.gov (United States)

1987-05-01

Periodic Table: fluorine , chlorine, bromine, iodine, and astatine. Fluorine is the most active of all chemical elements. 5/87 LIST OF ABBREVIATIONS...fire- retardant varnishes and as an aminizing agent for cotton fabric (901). 37.2 ENVIRONMENTAL FATE A1D EXPOSURE PATHWAYS 37.2.1 Transport in Soil...subject to packaging and labeling regulations. Directive on Paints, Varnishes . Printing Inks. Adhesives and Similar Product; (1334) Pentachlorophenol

Safety aspects and safety measures for the refrigerants N{sub 3} and F-CFC and CFC; Sicherheitsaspekte/Sicherheitsmassnahmen fuer Kaeltemittel NH{sub 3} und FCKW/FKW

Energy Technology Data Exchange (ETDEWEB)

Stuerchler, P. [GfG AG, Binz (Switzerland)

2001-09-01

Experts agree that ammonia is the best and most economical refrigerant for a number of applications, e.g. in skating rinks, the food industry, chemical plants, etc. It has good thermodynamic properties and a low ozone-depleting potential, but it is also an aggressive and toxic substance. The potential hazard to humans and plants can be reduced, however, by early detection of leaks. There are different specifications in different European countries. In Switzerland, the EKAS regulations apply. [German] In der Kaelteindustrie herrscht eine Uebereinstimmung, dass fuer eine Vielzahl von Anlagen, z.B. Eissportanlagen, Lebensmittelbetriebe, Chemieanlagen u.v.m., Ammoniak als das beste und wirtschaftlichste Kaeltemittel betrachtet wird. Die guten thermodynamischen Eigenschaften und das geringe Ozonabbaupotential haben Ammoniak zum wichtigsten Kaeltemittel in mittleren und Grossanlagen gemacht. Die aggressive und giftige Chemikalie Ammoniak birgt jedoch ein nicht zu unterschaetzendes Gefahrenpotential fuer Mensch und Anlage. Diese Gefahr kann weitestgehend eingedaemmt werden. Eine fruehe und zuverlaessige Erkennung von Leckagen minimiert deren Auswirkungen und Schaeden. Die Vorschriften hierzu sind laenderspezifisch in den Verordnungen und Richtlinien festgelegt. Fuer die Schweiz gelten die Richtlinien der EKAS. (orig.)

Ba-bah on tulnud / Liina Jänes

Index Scriptorium Estoniae

Jänes, Liina, 1977-

2005-01-01

Eesti noori disainereid-sisearhitekte ühendavast disainiagentuurist Ba-bah, selle eesmärgist. Agentuuri juhib Veiko Jääger. Mais 2005 Disaini- ja Arhitektuurigaleriis toimunud Ba-bahi avanäitusest, kus oli väljas töid EKA sisearhitektuuri, klaasi-, ehte- ja sepakunsti eriala üliõpilastelt ning metallmööbli valmistajalt Kalle Pruudenilt

Eilne, tänane ja homne ehtekunst Marzees / Eilve Manglus

Index Scriptorium Estoniae

Manglus, Eilve, 1977-

2004-01-01

Euroopa ehtekunstikoolide lõputööde väljapanek Marzee galeriis kuni 6. X. Kuraator Manuel Vilhena. Eestit esindanud Kertu Tubergi, Maarja Niinemäe ja Epp Perteli ning Bas Boumani, Jantine Bindelsi (Holland) ja Andrew Lambi (London) töödest. Marzee kollektsiooni kuuluvad EKA lõpetanud ehtekunstnike Villu Plingi, Piret Hirve ja Kristiina Lauritsa ehted

75 FR 15679 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

Science.gov (United States)

2010-03-30

... S.A. India: Certain Preserved Mushrooms, A-533-813 2/1/09-1/31/10 Agro Dutch Foods Limited (Agro.../09-1/31/10 Indonesia: Certain Preserved Mushrooms, A-560-802 2/1/09-1/31/10 PT Eka Timur Raya (ETIRA... of China: Certain Preserved Mushrooms,\\6\\ A-570-851....... 2/1/09-1/31/10 Ayecue (Liaocheng...

offline@online / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

1999-01-01

Raivo Kelomehe kureeritud offline@online meediakunsti festival alapealkirjaga "Media non grata" EKA küberkohvikus "Enter". Peamiselt Eesti ekspositsioonist. CD-ROMe esitlesid: R. Kelomees, M. Mäetamm, R. Keller, K. Sibul, I. Kivi, T. Lepik. M. Lillaku, J. Orgussaare, R. Kelleri, Pusa ja J. Bergi filmidest. Moskva Kaasaegse Kunsti Keskuse MediaArtLabi, M. Holboomi, G. Mülleri esinemisest

Tudengid tulid appi / Kaupo Kala ; kommenteerinud Heikki Zoova

Index Scriptorium Estoniae

Kala, Kaupo

2010-01-01

Koristustarvikuid ja -vahendeid tootval ettevõttel KH Teh Production OÜ valmisid koostöös Eesti Kunstiakadeemia tootedisaini osakonnaga ettevõtte tootearendusprojekt, disaini juhtimise kava, uus pakendisüsteem, stiiliraamat, arendati uusi tooteid. Töörühma, kuhu kuulusid neli üliõpilast ja kaks firma töötajat, juhtis EKA tootedisaini osakonna juhataja Heikki Zoova

Teine nahk ehk Ornament ja meie / Hanno Soans

Index Scriptorium Estoniae

Soans, Hanno, 1974-

2003-01-01

Arhitekt Adolf Loosi suhtumine ornamenti ja nahakaunistustesse, tattoo tagasitulek käibesse läänes XX sajandi II poolel. EKA nahakunsti eriala diplomandi Kerstin Raidma lõputööst, mis sisaldas seeria levinumaid tätoveeringupiirkondi katvaid nahast ehteid, lühidalt sama eriala lõpetaja Agnetha Kurusoni lõputööst "Kest" ja lõputööde hinnetest

Learned Helplessness Encountered by Michael Oher in the Blind Side Movie

OpenAIRE

PAMUNGKAS, DIMAS PROBO

2014-01-01

Pamungkas, Dimas Probo. 2014. Learned Helplessness Encountered by Michael Oher in The Blind Side Movie. Study Program of English, Department of Languages and Literature, Faculty of Culture Studies, Universitas Brawijaya. Supervisor: Dyah Eko Hapsari;Co-supervisor: Sarlettina Vidyayani EkaKeywords: Learned Helplessness, African-American, Psychological, Social Behavior, Depression, The Blind Side.Social behavior shows several interactions between person and social situations, which stress...

Näitused kunstiakadeemias

Index Scriptorium Estoniae

2003-01-01

EKA galeriis näitusel "Kirju pall" esitavad "krutskilist ökokunsti" rühmitus Puhas Rõõm, Mart Viljus, Anu Vahtra, Maris Mändel, Katrin Tees, Reimo Võsa-Tangsoo, Erki Kasemets, Raivo Hool. Aula fuajees näeb Jaak Soansi juhendamisel valminud skulptuuriosakonna õppetöid, valdavalt poliitikute skulptuurportreid. Osalevad Kristiina Järvelaid, Jelena Levtshenkova, Rene Reinumäe, Kaisa Uusoksa, Marju Vaher

Kuni 3. X on Frankfurdi lennujaamas (terminal 2)...

Index Scriptorium Estoniae

2004-01-01

Kaasaegse ehtekunsti noorima põlvkonna ehtete väljapanek. Näitusele valiti kahe EKA ehtekunsti eriala lõpetaja tööd. Maarja Niinemäe käevõrud pälvisid III preemia, Anni Kagovere mokume gane tehnikas hõbevaagnad äramärkimise. Septembris sai Maarja Niinemägi Leipzigi Midora messil ajakirja "GZ (Goldschmiede Zeitung) preemia "Best Graduate"

Kunstiakadeemia kolib ajutiselt Estonia puiesteele / Mari Kodres

Index Scriptorium Estoniae

Kodres, Mari

2009-01-01

Eesti Kunstiakadeemia on 2010. a. alguseks vanadest ruumidest kolinud hoonesse aadressil Estonia pst. 7. Rüütelkonna hoones leidis endale ajutise kodu vabade kunstide teaduskonna enamik erialasid. Veebruari algul toimuvast tühjendamispeost. EKA uue maja arhitektuurikonkursi võitis Taani arhitektuuribüroodes Sea ja Effekt valminud töö "Art Plaza". Uue hoone ehitus algab aprillis, valmimistähtajaks on 2012. a. kevad

Elu- ja mõtterännakud, minemised ja saatmised / Kaljo Põllu ; interv. Jonathan Roper, Marika Alver

Index Scriptorium Estoniae

Põllu, Kaljo, 1934-2010

2007-01-01

Kaljo Põllu oma kunstiõpingutest, loomingust, tööst Tartu Ülikooli kunstikabineti juhatajana, käikudest soomeugrilaste juurde, soome-ugri ekpeditsioonide korraldamisest kunstiinstituudis, ekspeditsioonide mõjust üliõpilaste mõtteviisile ja kunstile, rühmitusest Ydi, soomeugrilisusest eemaldumisest. Leedsi ülikooli inglise filoloogia lektor Jonathan Rops on käinud koos EKA üliõpilastega ekspeditsioonidel 1998., 1999. ja 2003. aastal

Talv 2015 = Winter 2015

Index Scriptorium Estoniae

2015-01-01

Aasta võitjad: Mart Kalm EKA rektoriks, Jaanus Samma Veneetsia biennaalil, Kris Lemsalu New Yorgi kunstimessil, Anu Vahtrale Köler Prize 2015, Raymond Pettiboni ja Marko Mäetamme isiknäitused Kumus, Katja Novitskova MoMa-s, Tanja Muravskajale Sadolini kunstipreemia, Tõnis Saadojale Konrad Mäe medal ja preemia, EKKM uued tegevjuhid on Marten Esko ja Johannes Säre, kunstnikupalka hakkavad saama viis Eesti kunstnikku

Eksperimendid ruumis / Toomas Tammis

Index Scriptorium Estoniae

Tammis, Toomas, 1969-

2014-01-01

EKA arhitektuuriteaduskonnas tehakse erialaprojekti kõrval väga erinevaid ruumilisi harjutusi. Esitletud on valik väiksemate töötubade ja kursuste töid: Kineetilise arhitektuuri töötuba "Volditav, klapitav, rullitav, pakitav", 2014 (juhendaja Renee Puusepp); Parameetrilise disaini valikaine, 2011 (juhendaja Raul Kalvo, assistent Kristjan Männigo); Maketistuudio, 2014 (juhendaja Paco Ulman); Eksperimentaalse arhitektuuri problemaatika, 2014 (juhendajad Martin Melioranski ja Paco Ulman)

Täna kell 19 avatakse Kultuuritehases Polymer...

Index Scriptorium Estoniae

2005-01-01

EKA Erasmuse programmi vahetusüliõpilaste ja nende eesti sõprade multimeediaüritus "PC - rahvusvahelised lained Tallinnas!". Osalevad Austria, Mehhiko, Saksamaa, Itaalia, Soome, Eesti, Poola, Hispaania, Prantsusmaa, Belgia, Šveitsi, Portugali, Tšehhi, USA ja Läti 2004. ja 2005. a. Eestis elanud kunstiüliõpilased. Kunstiprogrammile järgneb kontsert ja pidu DJde Andres Lõo, Valner Valme ja Christoph Höschele osavõtul

Meediakunsti mainet saab tõsta ainult järjekindla tööga / Jane Suviste, Piibe Piirma ; interv. Reet Varblane

Index Scriptorium Estoniae

Suviste, Jane

2006-01-01

Intervjuu 2006. a. jaanuaris loodud Eesti Meediakunstnike Ühingu asutajaliikmetega. Ühingu eesmärgist, MediaLabist Polümeeri tehases, koostööst EKA e-meedia keskusega, plaanitavast koostööst Tartu Kõrgema Kunstikooli ja Mooste külalisateljeega, austria kunstniku Barbara Musili videote näitusest MediaLabis 7. IV, mai algul toimunud üritusest "Switch", laste ja noorte kaasamisest jm.

A simple method for labelling proteins with 211At via diazotized aromatic diamine

International Nuclear Information System (INIS)

Wunderlich, G.; Franke, W.-G.; Fischer, S.; Dreyer, R.

1987-01-01

A simple and rapid method for labelling proteins with 211 At by means of a 1,4-diaminobenzene link is described. This link is transformed into the diazonium salt and subsequently reactions of both 211 At and proteins with the diazonium salt take place simultaneously. For possibly high yields of astatized protein an appropriate temperature of 273 K was found. The results demonstrate the difference between the reaction mechanisms of iodine and astatine with proteins. (author)

[Eesti Kunstiakadeemia uue hoone rahvusvaheline arhitektuurivõistlus] : EKA maja

Index Scriptorium Estoniae

2008-01-01

Žürii hääletustulemused ja hinnangud. I preemia - "Art Plaza", taani arhitektid Uffe Leth Laursen, Tue Hesselberg Foged, Karsten Gori, Sinus Lynge, Greta Tedje, Simon Sorensen, Lawrence Aeberhard, Lyndal Brown, Morgan Jacobsen (AB Sea + Effekt). II - "TLN 247", Hollandi AB NAT Architecten bv, M. van Zijl, V. van der Klei, F. A. van Manen, B. de Graaf, T. M. van Dijkhuizen, S. van der Meer, D. Awe, N. Limburg, J. Kuilman. III - "Arts Factory", Portugali AB Neralp-Arquitectura Engenharia e Construcoes Lda, Paulo Sergio Goncalves Teixeira de Sousa. Ergutuspreemia - "Publicsection", Hollandi AB BOARD, Bernd Upmeyer, kaastöö: Claudia Hess ja "Sashimi", jaapani arhitekt Francois Blanciak

Inimesed linnas = People in the city / Kaja Pae

Index Scriptorium Estoniae

Pae, Kaja

2006-01-01

Eesti näitus "Joint Space" Veneetsia 10. arhitektuuribiennaalil. AB Urban Mark: Ülar Mark, Indrek Tiigi, Kaja Pae, Yoko Alender, Raul Kalvo, Tartu Ülikooli Geograafiainstituut: Rein Ahas, Anto Aasa, Siiri Silm, Positium ICT: Margus Tiru, Erki Saluveer. Näitusel oli eksponeeritud kolm mobiilpositsioneerimisega läbi viidud case study (EKA liikmete liikumisuuring, Eestit külastanud turistide uuring, Tallinna regiooni pendelrändajate uuring). Bibliograafia lk. 33

Kui vana on kunstnik? / Anneli Porri

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2003-01-01

Rahvusvahelise kunstihariduse konverentsi "InSea on Sea" raames Kunstiakadeemia galeriis Karin Laansoo kureeritud Tallinna Kunstikooli õpilaste tööde näitus "MÄRKmed", Draakoni galeriis Mari Sobolevi kureeritud Viljandi Maagümnaasiumi kunstistuudio näitus "Sisseastumiseksam maailma", rahvusraamatukogus Anneli Porri kureeritud näitus "Kokkuvõte" EKA tänavuste lõpetajate töödest ja näitus "Leitud tagahoovist", Kullo galeriis rahvusvaheline näitus "Dialoog erinevuste vahel"

Leonardo da Vinci maali näidatakse peagi Kadriorus / Gianni Glinni, Orest Kormašov ; intervjueerinud Mart Zirnask

Index Scriptorium Estoniae

Glinni, Gianni

2009-01-01

Kadrioru Kunstimuuseumis eksponeeritakse 5.-12. veebruarini 2010. a. Leonardo da Vinci arvatavat autoportreed ning 6. veebruaril toimub Tallinna Ülikoolis maali analüüse tutvustav konverents. Portree leiti 2008. aastal ühest Lõuna-Itaalia erakogust. TLÜ kunstiosakonna juhataja Orest Kormašov valmistas maali järgi skulptuuri ja EKA tudeng ja graafiline disainer Helen Kokk arvutimudeli. Intervjuus jagavad teemakohaseid selgitusi üks uuringute eestvedaja Gianni Glinni ja Orest Kormašov

Kas praegune triennaal õnnestus? : tarbekunst / Ketli Tiitsar ; interv. R[eet] V[arblane

Index Scriptorium Estoniae

Tiitsar, Ketli

2006-01-01

Tallinna IV rakenduskunsti triennaali töögrupi liige K. Tiitsar triennaalist, näituse kujundusest (3+1 Arhitektid), eesti tarbekunstist, seminarist ja esitluste päevast (Mecky van den Brinki, Heli Hietala, Marie-Louise Kristenseni, Outi Liusvaara esinemine), satelliitnäitustest (Anneli Porri ja Pille-Triin Männiku kuraatoriprojekt "Teadus ja tänapäev", Hollandi Gerrit Rietveldi akadeemia ehteosakonna üliõpilaste tööde näitus EKA galeriis)

Reagents for Astatination of Biomolecules. 5. Evaluation of hydrazone linkers in 211At- and 125I-labeled closo-decaborate(2-) conjugates of Fab′ as a means of decreasing kidney retention

Science.gov (United States)

Wilbur, D. Scott; Chyan, Ming-Kuan; Hamlin, Donald K.; Nguyen, Holly; Vessella, Robert L.

2011-01-01

Evaluation of monoclonal antibody (MAb) fragments (e.g. Fab′, Fab or engineered fragments) as cancer-targeting reagents for therapy with the α-particle emitting radionuclide astatine-211 (211At) has been hampered by low in vivo stability of the label and a propensity of these proteins localize to kidneys. Fortunately, our group has shown that the low stability of the 211At label, generally a meta- or para-[211At]astatobenzoyl conjugate, on MAb Fab′ fragments can be dramatically improved by use of closo-decaborate(2-) conjugates. However, the higher stability of radiolabeled MAb Fab′ conjugates appears to result in retention of the radioactivity in kidneys. This investigation was conducted to evaluate whether the retention of radioactivity in kidney might be decreased by the use of acid-cleavable hydrazone between the Fab′ and the radiolabeled closo-decaborate(2-) moiety. Five conjugation reagents containing sulfhydryl-reactive maleimide groups, a hydrazone functionality and a closo-decaborate(2-) moiety were prepared. In four of the five conjugation reagents, a discrete polyethylene glycol (PEG) linker was used, and one substituent adjacent to the hydrazone was varied (phenyl, benzoate, anisole or methyl) to provide varying acid-sensitivity. In the initial studies, the five maleimido-closo-decaborate(2-) conjugation reagents were radioiodinated (125I or 131I), then conjugated with an anti-PSMA Fab′ (107-1A4 Fab′). Biodistributions of the five radioiodinated Fab′ conjugates were obtained in nude mice at 1, 4 and 24 h post injection (pi). In contrast to closo-decaborate(2-) conjugated to 107-1A4 Fab′ through a non-cleavable linker, two conjugates containing either a benzoate or a methyl substituent on the hydrazone functionality displayed clearance rates from kidney, liver and spleen that were similar to those obtained with directly radioiodinated Fab′ (i.e. no conjugate). The maleimido-closo-decaborate(2-) conjugation reagent containing a benzoate

Disaini ja rahvaste saatusest / Daniel Van der Velden ; interv. Kristjan Mändmaa

Index Scriptorium Estoniae

Van der Velden, Daniel

2008-01-01

17.-27. X 2008 oli Eesti Kunstiakadeemias näitus "Marsilt. Omaalgatuslikud projektid graafilises disainis". Kuraatorid: tšehhi disainerid Adam Machacek ja Radim Peshko. 17. X esinesid EKA saalis loengutega James Goggin Londoni firmast Practice ja Daniel van der Velden Hollandi disainikollektiivist Metahaven. 16. V osales D. van der Velden Eesti Disainiinstituudi korraldatud kohabrändingu-teemalises ümarlauas. D. van der Velden disaini, poliitika ja kohabrändingu tulevikust, Metahaveni disainitöödest

Disaini ja rahvaste saatusest / Daniel Van der Velden ; intervjueerinud Kristjan Mändmaa

Index Scriptorium Estoniae

Van der Velden, Daniel

2011-01-01

17.-27. X 2008 oli Eesti Kunstiakadeemias näitus "Marsilt. Omaalgatuslikud projektid graafilises disainis". Kuraatorid: tšehhi disainerid Adam Machacek ja Radim Peshko. 17. X esinesid EKA saalis loengutega James Goggin Londoni firmast Practice ja Daniel van der Velden Hollandi disainikollektiivist Metahaven. 16. V osales D. van der Velden Eesti Disainiinstituudi korraldatud kohabrändingu-teemalises ümarlauas. D. van der Velden disaini, poliitika ja kohabrändingu tulevikust, Metahaveni disainitöödest

Ülikoolid pole mängukannid / Sirje Tohver

Index Scriptorium Estoniae

Tohver, Sirje

2001-01-01

TPÜ korraldas 16. märtsil̀ 2001 ümarlaua "Ülikoolid pole mängukannid", kus oli arutusel riikliku koolitustellimuse vähenemine avalik-õiguslikele ülikoolidele. Osalesid TPÜ filoloogiateaduskonna dekaan dots. H. Mattisen, kultuuriteaduskonna dekaan prof. A. Avarand, akadeemiline prorektor dots. L. Jõgi, teadus- ja arendusprorektor prof. P. Normak, haridusminister T. Lukas, TPÜ rektor prof. M. Arvisto ja EKA rektor prof. A. Keskküla, TTÜ rektor prof. A. Keevallik, EMA õppeprorektor A. Pung

30. X tähistab EKA 90. aastapäeva

Index Scriptorium Estoniae

2004-01-01

Näitustest. 29. X audoktorite Udo Kultermanni ja Juhani Pallasmaa loengud ning ümarlaud "Disain, tulevik ja identiteet", kus esitavad ettekande Halldor Gislason (Reykjavik), Francois Penz (Cambridge), Bruce Brown (Brighton), Peter McGrory (Helsingi) ja Michael U. Hensel (London), ümarlauda juhib Jüri Soolep. 30. X vilistlaspäev, audoktoriteks promoveeritakse Juhani Pallasmaa, Udo Kultermann, Lars Olof Larsson ja Yrjö Sotamaa

"Art Plaza" oli vaieldamatult parim projekt : EKA maja / Indrek Allmann

Index Scriptorium Estoniae

Allmann, Indrek, 1972-

2008-01-01

Eesti Kunstiakadeemia uue hoone rahvusvahelisel arhitektuurikonkursil I preemia saanud Taani arhitektuuribüroode Sea + Effekt projektis "Art Plaza" on arvestatud ajaloolist konteksti ja jätkusuutlikkust. "Art Plaza" taustaks näiteid arhitektuuriajaloost

Pärnus on uus nüüdiskunsti galerii!

Index Scriptorium Estoniae

2004-01-01

17. VI Pärnus Lõuna t. 20 avatud eksperimentaalne Rael Artel Gallery keskendub esimesel hooajal eelkõige foto ja sound art'i eksponeerimisele. Kuraatorid: Anu Allas, Andreas W, EKA kunstiteaduse üliõpilased Marion Tupits, Aleksander Tsapov, Urmas Oja. Galeristi Rael Arteli kureeritud avanäitusel "Jagatud kehad" on väljas Eveli Variku, Tanja Muravskaja, Imre Malva, Andreas W ja Haide Rannakivi tööd. Galerii audiogalerii avatakse Projekt Unisoni (Hello Upan, Raul Keller, Heikki Tikas) mürateosega "DOHC"

Viis kandidaati ühele õpetajakohale / Raivo Juurak

Index Scriptorium Estoniae

Juurak, Raivo

2007-01-01

Programmist "Noored kooli", etapi lõpuks selgitati välja 13 noort, kes lähevad tänavu 1. septembril kooli õpetajaks. Oma hinnangu programmile annavad üliõpilased: TTÜ geenitehnoloogiast P. Uuemaa, TTÜ logistikast K. Lillemets, EKA tekstiilidisainist I. Gross, TÜ inglise filoloogiast R. Kurg, TÜ hispaania keele ja politoloogia üliõpilane L. Prikk, TLÜ inglise filoloogiast T.-K. Kaber, TÜ eesti keel vene koolis erialalt N. Reppo, TTÜ geenitehnoloogiast P. Ahte ja TÜ inglise filoloogiast H. Haljaste

Astatine-211 labelled proteins and their stability in vivo

International Nuclear Information System (INIS)

Yi Changhou; Jin Jannan; Zhang Shuyuan; Wang Ketai; Zhang Dayuan; Zhou Maolun

1989-01-01

211 At or 131 I labelled proteins, e.g. 211 At-IgG or 211 At-BSA (bovine serum albumin) were prepared by 211 At reaction with the diazo-compound of para-aminobenzoic acid, which is then conjugated with IgG or BSA via an acylation reaction. The 211 At-carbon bond was found metabolically stable under in vivo conditions. For the labelling of proteins with 211 At or 131 I, other methods of direct oxidation are also described. The results show that for the labelling of proteins with 211 At, high rate of incorporation can be obtained with hydrogen peroxide as oxidant, but the labelling of proteins with 131 I is more favourable with the strong oxidant Chloramine-T. (author) 12 refs.; 6 figs

Kinetic experiments for evaluating the Nernst-Monod model for anode-respiring bacteria (ARB) in a biofilm anode.

Science.gov (United States)

Torres, César I; Marcus, Andrew Kato; Parameswaran, Prathap; Rittmann, Bruce E

2008-09-01

Anode-respiring bacteria (ARB) are able to transfer electrons from reduced substrates to a solid electrode. Previously, we developed a biofilm model based on the Nernst-Monod equation to describe the anode potential losses of ARB that transfer electrons through a solid conductive matrix. In this work, we develop an experimental setup to demonstrate how well the Nernst-Monod equation is able to represent anode potential losses in an ARB biofilm. We performed low-scan cyclic voltammetry (LSCV) throughout the growth phase of an ARB biofilm on a graphite electrode growing on acetate in continuous mode. The (j)V response of 9 LSCVs corresponded well to the Nernst-Monod equation, and the half-saturation potential (E(KA)) was -0.425 +/- 0.002 V vs Ag/AgCl at 30 degrees C (-0.155 +/- 0.002 V vs SHE). Anode-potential losses from the potential of acetate reached approximately 0.225 V at current density saturation, and this loss was determined by our microbial community's E(KA) value. The LSCVs at high current densities showed no significant deviation from the Nernst-Monod ideal shape, indicating that the conductivity of the biofilm matrix (kappa(bio)) was high enough (> or = 0.5 mS/cm) that potential loss did not affect the performance of the biofilm anode. Our results confirm the applicability of the Nernst-Monod equation for a conductive biofilm anode and give insights of the processes that dominate anode potential losses in microbial fuel cells.

Me aiaäärne tsivilisatsioon / Andri Ksenofontov

Index Scriptorium Estoniae

Ksenofontov, Andri, 1962-

2008-01-01

Gerhard Richteri näitus "Ülevaade" 6. VI-17. VIII ja Eha Komissarovi kureeritud eesti kunstnike linnakeskkonna-teemaline näitus "Koht, mis paneb liikuma" 20. VI-17. VIII Kumu Kunstimuuseumis. Lühidalt Tõnis Saadoja Gerhard Richteri portreede seeriast "Mainstream" Kumu Kunstimuuseumis. Maarit Murka töödest, Kaarel Nurga fotodest, Anton Kooviti, Uku ja Remi grafititoast, Raoul Kurvitza arvutiinstallatsioonist "Pentatonic Color System II" (helilooja Ariel Lagle), Reet Ausi, Marit Ahvena,Ville Hyvöneni, Hula, EKA moedisaini ja Tartu Kõrgema Kunstikooli tekstiili- ja fotoosakonna projektist "Üle prahi", Kaido Ole installatsioonist "Koosolek"

Riigikogu hoone / Herbert Voldemar Johanson, Eugen Habermann, Alar Kotli...[jt.

Index Scriptorium Estoniae

2007-01-01

23 ill.; fotod: Andres Teiss; autorid: H. Johanson, E. Habermann, saaliavade ja aknapõskede kujundamisel oli abiks J. Koort; 1935. a. rajati A. Kotli projekti järgi lossi lõunatiib; valge saal rekonstrueeriti 1936. a. A. Perna ja J. Ostrati kavandite järgi; Eesti taasiseseisvumise järel on hoonet M. Kalmu, L. Pärtelpoja, M. ja K. Kurismaa ning Ü. Saare juhendamisel renoveeritud; Riigikogu esimehe kabineti vaiba (1938) kavandas Adamson-Eric, kontorimööbli kujundasid 1997. a. EKA sisearhitektuuri üliõpilased L. Pärtelpoja juhendamisel

Oskusteabe tarbekunsti-tiritamm / Lylian Meister

Index Scriptorium Estoniae

Meister, Lylian, 1966-

2009-01-01

Tallinna 5. rakenduskunsti triennaalist. Peanäitus "Know how" Eesti Tarbekunsti- ja Disainimuuseumis kuni 21. 02. 2010 (kuraator Kärt Maran, kujundajad: Ott Kadarik, Tuuli Aule). Kolm võrdset preemiat said Marta Boan (Hispaania), autorite kollektiiv Jaan Evart (Eesti), Julian Hagen (Austria) ja Daniel Maarleveld (Holland) ning Kieren Jones (Suurbritannia). Satelliitnäitused: "EKA Know How. See on imelihtne?" (kuraatorid: Eeva Käsper, Tiina Sarapu) Eesti Kunstiakadeemia galeriis 12. 11.-10. 12. 2009, "Praktiline Kunst ja Kodu" (kuraator Kai Lobjakas, kujundaja Mikk Heinsoo) Hobusepea galeriis 14.-23. 11. 2009

Eesti disaini uudised / Kai Lobjakas

Index Scriptorium Estoniae

Lobjakas, Kai, 1975-

2006-01-01

Eesti Kunstiakadeemia üliõpilaste Kadri Kruus-Laurimaa kott-jope, Riho Tiiveli lusikas "Spoon container" ja Ülle Jehe sisustuspadjad "Roll it!" valiti Prantsusmaal toimunud rahvusvahelisel kunsti-ja disainikõrgkoolide võrgustiku CUMULUS konkursil "European Ways of Life" nominentide hulka. EKA sisearhitektuuri eriala üliõpilaste toolide hindamisest. Mari Adamsoni nimelise noore tekstiilikunstniku preemia pälvis Kadri Klampe. Eesti Ajaloomuuseumis Maarjamäe lossis avatud moenäitusest "Paula, sul on poisipea!", mille koostas Helle Avila, konsulteeris Anu Ojavee, kujundasid Krista Lepland ja Malle Jürgenson büroost Laika, Belka ja Strelka

20. VI avatakse EKA galeriis rahvusvaheline fotonäitus "Fragile Distance"

Index Scriptorium Estoniae

2003-01-01

Kuraatorid David Bate, Eve Kiiler. Osalevad Londonis elavad ja töötavad fotograafid Denny Robson, Adam Green, Michelle Atherton (Inglismaa), Eva Riegler (Austria), Andreas Hablutzel (Šveits), Angeliki Douveri, Stella Baraklianou (Kreeka), Simona Dell'Agli (Itaalia)

Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

International Nuclear Information System (INIS)

1995-07-01

This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

Värvikas Riigikogu / Lylian Meister

Index Scriptorium Estoniae

Meister, Lylian, 1966-

2007-01-01

1920-1922 Herbert Johansoni ja Eugen Habermanni projekti järgi ehitatud Riigikogu hoonest. Saaliavade ja aknapõskede kujundamisel oli abiks Jaan Koort. 1935. a. rajati Alar Kotli projekti järgi lossi lõunatiib.Valge saal rekonstrueeriti 1936. a. Artur Perna ja Johann Ostrati kavandite järgi. Eesti taasiseseisvumise järel on hoonet Mart Kalmu, Leila Pärtelpoja, Mari ja Kaarel Kurismaa ning Ülar Saare juhendamisel renoveeritud. Riigikogu esimehe kabineti vaiba (1938) kavandas Adamson-Eric, kontorimööbli kujundasid 1997. a. EKA sisearhitektuuri üliõpilased L. Pärtelpoja juhendamisel. 23 ill

Predatory Pricing: Persaingan Harga Minimarket dan Gadde-Gadde dalam Metafora Cerpen

Directory of Open Access Journals (Sweden)

Andi Sri Wahyuni

2015-08-01

Full Text Available This article is aimed to explore the determination of agressive cost of product (predatory pricing used by minimarket. Short story metaphor by Eka Kurniawan, “Kisah Seorang Kawan” as methodology. The “father” figure in this story has similiar condition with enterpreneur of gadde-gadde. The story begins with the attendant of “the rich merchant” who represent the arrival of minimarket in housing area at Makassar. Through the short story, strategy of predatory pricing could attract customer to move from gadde-gadde to minimarket. Finally, these changes could diminish small businesses which are become the primary economic sector.

STRATEGI KOMUNIKASI PEMASARAN TERPADU EKOWISATA DI KEBUN RAYA EKA KARYA, BEDUGUL, BALI

Directory of Open Access Journals (Sweden)

Muntadliroh Muntadliroh

2016-08-01

Full Text Available Ecotourism of Bali Botanical Garden, Bedugul, Tabanana Regency, Bali, has been able to increase the number of visitors from time to time though it is still far from the optimum level. In 2010-2011 the number of visitors at Bali Botanical Gardens was counted for 368.927 people. Based on the data, visitors interest to visit Bali Botanical Garden are still low. Facing this problem, integrated marketing communication strategy is needed.This paper discusses implementation of integrated marketing communication concept created by Philip Kotler to the market ecotourism at Bali Botanical Garden, by using case study for qualitative research.The results of this analysis show that implementing this concept made a better relationship between Bali Botanical Garden and its visitors, also increasing quantity of its visitors.

On the optimization of thorium bundle distribution in the initial core loading for a PHWR

International Nuclear Information System (INIS)

Mishra, S.; Ray, S.; Kumar, A.N.; Modak, R.S.; Ganesan, S.

2009-01-01

If the initial core of Indian 220 MWe PHWR is loaded with all fresh Natural Uranium fuel, only about 70% Full Power can be drawn in the initial operation due to large power peaking. It is possible to load few tens of Th bundles at selected locations to get nearly full power without violating any safety limits. Finding the best possible locations is, however, a fairly complex and massive combinatorial optimization problem. Here, optimum solutions are obtained by a latest evolutionary algorithm called EDA implemented on the EKA built at Computational Research Laboratories (CRL) in Pune. The effect of varying the number of Th bundles on results is discussed. (author)

Sisearhitektide Liit premeeris / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2004-01-01

ESL aastapreemiad 2003: parima ajaloolise interjööri ja parima kodu preemia - Leila Pärtelpoja ja Karl-Erik Tarbe kujundatud Villa Tannenrode Lükati teel Tallinnas, parim ühiskondlik interjöör - 3+1 arhitektide (Markus Kaasik, Andres Ojari, Ilmar Valdur, kaasautorid Ralf Lõoke, Kalle Komissarov; söögikoha tegi Taavi Aunre ja ühiskondliku mööbli Gert Sarv) kujundatud Mustamäe keskus, publitsistikapreemia - EKA sisearhitektuuri kateedri kataloog "Eesti Kunstiakadeemia sisearhitektuuri osakond 2002-2003". Ära märgiti kaks tooteseeriat: EGO garderoobid (EGO Mööbel OÜ) ning Jan J. Grapsi loodud "Incognito" mööblisari

Microdosimetry of astatine-211 and comparison with that of iodine-125

International Nuclear Information System (INIS)

Unak, T.

2001-01-01

211 At is an alpha and Auger emitter radionuclide and has been frequently used for labeling of different kind of chemical agents. 125 I is also known as an effective Auger emitter. The radionuclides which emit short range and high LET radiations such as alpha particles and Auger electrons have high radiotoxic effectiveness on the living systems. The microdosimetric data are suitable to clarify the real radiotoxic effectiveness and to get the detail of diagnostic and therapeutic application principles of these radionuclides. In this study, the energy and dose absorptions by cell nucleus from alpha particles and Auger electrons emitted by 211 At have been calculated using a Monte Carlo calculation program (code: UNMOC). For these calculations two different model corresponding to the cell nucleus have been used and the data obtained were compared with the data earlier obtained for 125 I. As a result, the radiotoxicity of 211 At is in the competition with 125 I. In the case of a specific agent labelled with 211 At or 125 I is incorporated into the cell or cell nucleus, but non-bound to DNA or not found very close to it, 211 At should considerably be much more radiotoxic than 125 I, but in the case of the labelled agent is bound to DNA or take a place very close to it, the radiotoxicity of 125 I should considerably be higher than 211 At. (author)

Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates.

Science.gov (United States)

Teze, David; Sergentu, Dumitru-Claudiu; Kalichuk, Valentina; Barbet, Jacques; Deniaud, David; Galland, Nicolas; Maurice, Rémi; Montavon, Gilles

2017-05-31

211 At is a most promising radionuclide for targeted alpha therapy. However, its limited availability and poorly known basic chemistry hamper its use. Based on the analogy with iodine, labelling is performed via astatobenzoate conjugates, but in vivo deastatination occurs, particularly when the conjugates are internalized in cells. Actually, the chemical or biological mechanism responsible for deastatination is unknown. In this work, we show that the C-At "organometalloid" bond can be cleaved by oxidative dehalogenation induced by oxidants such as permanganates, peroxides or hydroxyl radicals. Quantum mechanical calculations demonstrate that astatobenzoates are more sensitive to oxidation than iodobenzoates, and the oxidative deastatination rate is estimated to be about 6 × 10 6 faster at 37 °C than the oxidative deiodination one. Therefore, we attribute the "internal" deastatination mechanism to oxidative dehalogenation in biological compartments, in particular lysosomes.

Chemical and nuclear properties of lawrencium (element 103) and hahnium (element 105)

International Nuclear Information System (INIS)

Henderson, R.A.

1990-01-01

The chemical and nuclear properties of Lr and Ha have been studied, using 3-minute 260 Lr and 35-second 262 Ha. The crystal ionic radius of Lr 3+ was determined by comparing its elution position from a cation-exchange resin column with those of lanthanide elements having known ionic radii. Comparisons are made to the ionic radii of the heavy actinides, Am 3+ through Es 3+ , obtained by x-ray diffraction methods, and to Md 3+ and Fm 3+ which were determined in the same manner as Lr 3+ . The hydration enthalpy of -3622 kJ/mol was calculated from the crystal ionic radius using an empirical form of the Born equation. Comparisons to the spacings between the ionic radii of the heaviest members of the lanthanide series show that the 2Z spacing between Lr 3+ and Md 3+ is anomalously small, as the ionic radius of Lr 3+ of 0.0886 nm is significantly smaller than had been expected. The chemical properties of Ha were determined relative to the lighter homologs in group 5, Nb and Ta. Group 4 and group 5 tracer activities, as well as Ha, were absorbed onto glass surfaces as a first step toward the determination of the chemical properties of Ha. Ha was found to adsorb on surfaces, a chemical property unique to the group 5 elements, and as such demonstrates that Ha has the chemical properties of a group 5 element. A solvent extraction procedure was adapted for use as a micro-scale chemical procedure to examine whether or not Ha displays eka-Ta-like chemical under conditions where Ta will be extracted into the organic phase and Nb will not. Under the conditions of this experiment Ha did not extract, and does not show eka-Ta-like chemical properties

19. IV avati EKA galeriis Tartu noore maali näitus "9 elu"

Index Scriptorium Estoniae

2004-01-01

Autorid Jaan-Jürgen Klaus, Margus Liivak, Kaie Luik, Eda Lõhmus, Rauno Th. Moss, Maris Palgi, Jane Remm, Hando Tamm ja Ode Taul on Tartu Ülikooli maaliosakonna 2000-2003 lõpetanud või 2004 lõpetavad noored kunstnikud. 20. IV seminaril "Üle ja ümber Tartu noore maali" esinesid Anu Allas, Rauno Th. Moss, Evelyn Müürsepp

Use of interhalogen exchange for preparation of astatine-benzene and iodo-benzene

International Nuclear Information System (INIS)

Kolachkovski, A.; Khalkin, V.A.

1976-01-01

Experimental testing of interhalogen exchange between the solid and liquid phases has been carried out at 155 deg C with particular reference to a NaOH-Na 131 I-BrPh system. Iodine transition rate is dependent on the process duration and alkali amount. The relative amounts of 131 IPh resultant from the reaction of interhalogen exchange is evaluated by paper chromatography. The results obtained may be considered as those which provide experimental support for the assumed efficiency of the production of 131 IPh based on the reaction of interhalogen exchange to yield 70-80% 131 IPh

Jejak Praktik Militerisme dalam Puisi Indonesia

Directory of Open Access Journals (Sweden)

Yulitin Sungkowati

2007-12-01

Full Text Available The existence of military in a country does not automatically mean militarism. However, during the New Order era, militarism was used to dominate political life and became a power shield as an excuse to maintain national stability. The military practice could be seen, among other things in Indonesian literary works, particularly in Wiji Thukul's, Rendra's, Eka Budianta's, and K.H. A. Mustafa Bisri's writing as a reflection of his period. These poems depict military action in the New Order power such as in the land reform case, workers protest, and the 27th of July incident. Military action has become a violent pattern to silence these unpleasant incidents. Some critical activists experienced these violent actions such as terror, kidnapping, and torturing,

``From Fundamental Motives to Rational Expectation Equilibrium[REE, henceworth] of Indeterminacy''

Science.gov (United States)

Maksoed, Ssi, Wh-

For ``Principle of Indeterminacy''from Heisenberg states: ``one of the fundamental cornerstone of quantum mechanics is the Heisenberg uncertainty principle''.whereas canonically conjugate quantities can be determined simultaneously only with a characteristic indeterminacy[M. Arevalo Aguilar, et.al]. Accompanying Alfred North Whitehead conclusion in ``The Aims of Education''that mathematical symbols are artificial before new meanings given, two kinds of fundamental motives: (i) expectation-expectation, (ii) expectation-certainty inherently occurs with determinacy properties of rational expectation equilibrium(REE, henceworth)- Guido Ascari & Tizano Ropele:''Trend inflation, Taylor principle & Indeterminacy'', Kiel Institute, June 2007. Furthers, relative price expression can be compare of their α and (1 - α) configurations in the expression of possible activity. Acknowledgment to Prof[asc]. Dr. Bobby Eka Gunara for ``made a rank through physics'' denotes...

18. XII kell 12 kaitstakse EKA E-meedia keskuses 4 magistritööd...

Index Scriptorium Estoniae

2002-01-01

Kristel Sibul "Kehatud kehad - kehad ja identiteet internetis" (juh. Katrin Kivimaa), Ivika Kivi "Virtuaalsed õpitarkvarad" (juh. Mare Emmott Tralla), Maris Lindoja "Digitaalne ruum" (juh. Andres Kurg), Raul Keller "Corporate Consulting in the Digital Age - Jamming vith the Culture" (juh. Richard Barbrook)

Chemical concentration of a new natural spontaneously fissionable nuclide from solutions with low salt background

International Nuclear Information System (INIS)

Korotkin, Yu.S.; Ter-Akop'yan, G.M.; Popeko, A.G.; Drobina, T.P.; Zhuravleva, E.L.

1982-01-01

The results of experiments on further concentration of a new natural spontaneously fissionable nuclide, the concentrates of which form the Cheleken geothermal brines have been obtained, are presented. The conclusions are drown about the chemical nature of a new spontaneously fissionable nuclide. It is a chalcophile element which copreipitates with sulphides of copper, lead, arsenic and mercury from weakly acid solutions. The behaviour of the new nuclide in sulphide systems in many respects is similar to the behaviour of polonium, astatine and probably of bismuth. The most probable stable valence of the new nuclide varies from +1 up to +3. The data available on the chemical behaviour of the new nuclide as well as the analysis over contamination by spontaneously fissionable isotopes permit to state that the new natural spontaneously fissionable nuclide does not relate to the known isotopes

Is Electronegativity a Useful Descriptor for the 'Pseudo-Alkali-Metal' NH4?

International Nuclear Information System (INIS)

Whiteside, Alexander; Xantheas, Sotiris S.; Gutowski, Maciej S.

2011-01-01

Molecular ions in the form of 'pseudo-atoms' are common structural motifs in chemistry, with properties that are transferrable between different compounds. We have determined the electronegativity of the 'pseudo-alkali metal' ammonium (NH4) and evaluated its reliability as a descriptor in comparison to the electronegativities of the alkali metals. The computed properties of its binary complexes with astatine and of selected borohydrides confirm the similarity of NH4 to the alkali metal atoms, although the electronegativity of NH4 is relatively large in comparison to its cationic radius. We paid particular attention to the molecular properties of ammonium (angular anisotropy, geometric relaxation, and reactivity), which can cause deviations from the behaviour expected of a conceptual 'true alkali metal' with this electronegativity. These deviations allow for the discrimination of effects associated with the polyatomic nature of NH4.

Solidification of fly ash from municipal solid waste incinerator by the use of sorel cement

Directory of Open Access Journals (Sweden)

Hepworth Malcolm T.

1996-03-01

Full Text Available Spaľovanie tuhého komunálneho odpadu významne redukuje objem a hmotnosť tuhého komunálneho odpadu, avšak zvyšky po spaľovaní sú klasifikované ako nebezpečné odpady. Použitím stabilizačnej technológie solidifikácie popolčeka z elektrostatických odlučovačov spaľovne na komunálny odpad využitím Sorelovho cementu vznikne popolčekový cement, ktorého environmentálne a inžinierske vlastnosti ponúkajú možnosť jeho užitočného využitia pre účely stavebníctva.

Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

DEFF Research Database (Denmark)

Back, T.; Haraldsson, B.; Hultborn, R

2009-01-01

of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose limit for the bone marrow and well within the range for therapeutic efficacy on tumors. Astatinated MX35-F(ab')(2) monoclonal antibodies were administered intravenously to nude mice. Both non-tumor-bearing animals...... manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions...... in GFR. These results suggest that a mean absorbed dose to the kidneys of approximately 10 Gy is acceptable, and that the kidneys would not be the primary dose-limiting organ in systemic alpha-RIT when using (211)At-MX35-F(ab')(2) Udgivelsesdato: 2009/12...

Boiling points of the superheavy elements 117 and 118

International Nuclear Information System (INIS)

Takahashi, N.

2001-01-01

It has been shown that the relativistic effect on the electrons reveal in the heavy element region. What kind of changes will appear in the heavy elements because of the relativistic effects? Can we observe the changes? We observed that the boiling points of astatine and radon are lower than that extrapolated values from lighter elements in the same groups. Systematic behavior of the elements on the boiling point was examined and a new method for the estimation of the boiling points of the superheavy elements in the halogen and rare gases has been found. The estimated values of the elements 117 and 118 are 618 and 247 K, respectively which are considerably lower than those obtained until now. If these values are correct the production of the superheavy elements with heavy ions reaction may be affected. Further, the chemical properties may be fairly different from the lighter elements. (author)

Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

DEFF Research Database (Denmark)

Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena

2014-01-01

Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... mechanism as (131)I [1], in cancer treatment has increased during recent years because of its high efficiency in inducing biological damage and beneficial dose distribution when compared to low-LET radiation. Most knowledge of the DNA damage response in thyroid is from studies using low-LET irradiation...... and much less is known of high-LET irradiation. In this paper we investigated the DNA damage response and biological consequences to photons from Cobolt-60 ((60)Co) and alpha particles from (211)At in normal primary thyrocytes of different cell cycle status. For both radiation qualities the intensity...

Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

Energy Technology Data Exchange (ETDEWEB)

Wilbur, Daniel Scott

2012-12-12

Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer

International Nuclear Information System (INIS)

Willhauck, Michael J.; Sharif Samani, Bibi-Rana; Goeke, Burkhard; Wolf, Ingo; Senekowitsch-Schmidtke, Reingard; Stark, Hans-Juergen; Meyer, Geerd J.; Knapp, Wolfram H.; Morris, John C.; Spitzweg, Christine

2008-01-01

We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of 131 I. In the current study, we studied the potential of the high-energy alpha-emitter 211 At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of 131 I due to rapid iodide efflux. We investigated uptake and therapeutic efficacy of 211 At in LNCaP cells stably expressing NIS under the control of the PSA promoter (NP-1) in vitro and in vivo. NP-1 cells concentrated 211 At in a perchlorate-sensitive manner, which allowed a dramatic therapeutic effect in vitro. After intrapertoneal injection of 211 At (1 MBq), NP-1 tumors accumulated approximately 16% ID/g 211 At (effective half-life 4.6 h), which resulted in a tumor-absorbed dose of 1,580 ± 345 mGy/MBq and a significant tumor volume reduction of up to 82 ± 19%, while control tumors continued their growth exponentially. A significant therapeutic effect of 211 At has been demonstrated in prostate cancer after PSA promoter-directed NIS gene transfer in vitro and in vivo suggesting a potential role for 211 At as an attractive alternative radioisotope for NIS-targeted radionuclide therapy, in particular in smaller tumors with limited radionuclide retention time. (orig.)

Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy

International Nuclear Information System (INIS)

Foulon, Catherine F.; Alston, Kevin L.; Zalutsky, Michael R.

1998-01-01

We report herein the preparation and biological evaluation of two radioastatinated biotin conjugates, (3-[ 211 At]astatobenzoyl)norbiotinamide and ((5-[ 211 At]astato-3-pyridinyl)carbonyl)norbiotinamide. Both conjugates were stable in the presence of human serum and cerebrospinal fluid as well as murine serum, indicating a resistance to degradation to biotinidase. The normal tissue clearance of (3-[ 211 At]astatobenzoyl)norbiotinamide and ((5-[ 211 At]astato-3-pyridinyl)carbonyl)norbiotinamide was rapid, as observed previously with their iodo analogues. Also reported are the first syntheses of N-succinimidyl 5-[ 211 At]astato-3-pyridinecarboxylate and 3-[ 211 At]astatoaniline, two reagents of potential utility for labeling proteins and peptides with 211 At

Sisustusuudised / Lylian Meister

Index Scriptorium Estoniae

Meister, Lylian, 1966-

2006-01-01

Disainiaasta korraldajad on kuulutanud välja konkursi kõigile Eesti inimestele, ideed saata EKA Disaini Innovatsioonikeskusesse. Philippe Starcki disainitud lamp Bedside Gun firmale Flos. Laura Ashley kaubamärk on jõudnud Tallinna. Saksa firma Sanaform ergonoomiline tool Falto on müügil kaupluses And Tallinna Kaubamajas. Paola Suhoneni loodud kaubamärgi IvanaHelsinki moekauplusest Helsingis. Tõnis Vellama disainitud seinavalgustit ANGEL toodab Eesti firma SEOS Valgustus, müüb Nu Nordic. Ilona Gurjanova ja Soome ettevõtte Savcor One Line koostöös sündinud LeArt kahhelkivide kollektsiooni tutvustati 10D näitusel Helsingi Design Forumis ja see oli edukas disainimessil Maison & Objet Pariisis. Kris Lemsalu keraamikat müüb Nu Nordic. Sixten Heidmetsa ja Sirli Põllumäe noortemööbli kollektsiooni, mida toodab Fellin Furniture, saab osta Aatriumi Sisustuskaubamajast

Eesti kunsti superego, ego ja id / Andri Ksenofontov

Index Scriptorium Estoniae

Ksenofontov, Andri, 1962-

2007-01-01

Graafikanäitus "Kohanemised" Rahvusraamatukogus. JP Kaljoneni (sünd. 1976, Soome) fotonäitus "Integrations" Draakoni galeriis. Jevgeni Klimovi (1946-1996) fotonäitus Venemaa saatkonna galeriis. Nikolai Kormashovi portree-etüüdide väljapanek Haus galeriis. Jaan Elkeni popmuusikast inspireeritud maalinäitus Hobusepea galeriis. Näitus "Skulptuur räägib : võim ja vabadus" Tallinna Kunstihoones. Tanja Muravskaja video ja fotoseeria "Positsioonid" ning Kristina Normani videoinstallatsioon "Monoliit. Eternal Mix" Noorte kunstnike biennaalil Rüütelkonna hoones. Kaido Ole väljapanek "Hümn" Vaal-galeriis. Anu Pennaneni video "Sõprus" Kumus. Flo Kasearu video "Mulgi reisid" ja näitus ArtDepoo Galeriis. Eeva Käsperi klaasinäitus "Õrn. Salvestatud mõjutused" Hop galeriis. EKA metallikunsti ja skulptuuri eriala üliõpilaste kollektiivse alateadvusliku joonistamise näitus "Entroopia" Pikk t. 42 ja muud

New developments of the in-source spectroscopy method at RILIS/ISOLDE

CERN Document Server

Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

2013-01-01

At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

Studies of Stable Octupole Deformations in the Radium Region

CERN Multimedia

2002-01-01

The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

Biological toxicity of intracellular radionuclide decay. Part of a coordinated programme on radiation biology of Auger emitters and their therapeutic applications

International Nuclear Information System (INIS)

Hofer, K.G.

1980-06-01

Internal radiotherapy should be performed with short-lived radionuclides which emit high LET radiation and short ranged radiation, and accumulated within cancers. Based on these considerations, several radionuclides (tritium, copper-64, gallium-67, iodine-123, iodine 125, iodine-131 and astatine-211) were chosen and their toxicity was assessed using cell division in mammalian cultured cells as a criterion. It was apparent that the toxic effects obtained with 125 I greatly exceeded those observed in cells treated with any other radionuclides. The possible hypotheses to explain the excessive radiosensitivity of 125 I were discussed in relation to microdosimetry calculation. It was also found that the division delay induced by radionuclide decay is primarily due to damage to the cell nucleus but not to the plasma membrane. The key problem remains the development of agents which can serve as carriers for radionuclide accumulation within tumors. Although several promising approaches (Synkavit, tamoxifen, iododeoxyuridine, antibodies, liposomes) were investigated, only 125 I-labelled Synkavit would be desirable for clinical application

Production of Astatine-211 at the Duke University Medical Center for its regional distribution

Energy Technology Data Exchange (ETDEWEB)

Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

2016-01-01

Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as ²¹¹At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of ²¹¹At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve ²¹¹At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used ²¹¹At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a ²¹¹At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

Kuni 13. III saab Y-galeriis vaadata EKA avatud akadeemia näitust "Lavastused ja interpretatsioonid"

Index Scriptorium Estoniae

2005-01-01

Stseenid modellidega on lavastanud Tiina Tammetalu, maalinud-interpreteerinud üliõpilased Ulvi Kuldkepp, Margit Maksing, Liis-Theresia Ulman, (Margus) Soho Fond, Ian Oja, Alissa Didõk-Riikjärv ja Monika Sorokina. Väljapaneku on kujundanud T. Tammetalu ja U. Kuldkepp. Projekt "Happy" on T. Tammetalu kureeritav näitusesari, mis tutvustab tema juhendamisel tehtud üliõpilaste töid

Mis tuleb

Index Scriptorium Estoniae

2005-01-01

Pärnu Uue Kunsti Muuseumis Uno Roosvaldi maalide ja graafika näitus "Mõttes Kihnus", Heino Lillepuu kollaazhide näitus "Kõik naised on inglid". Tartu Mänguasjamuuseumis jõuluehete näitus. Rahvusraamatukogu fuajees Andy Horneri näitus "Terra Borealis". Eesti Rahva Muuseumis näitus "Põhjamaine tunnetus", mis tutvustab Sleipneri stipendiumi saanud noorte kunstnike valiktöid. Iisaku muuseumis jõulupostkaartide näitus. Eesti Tarbekunsti- ja Disainimuuseumis näitus "Klaashelmed maailma rahvaste kultuuris" (suur osa helmeist ja helmetikandeist on Torben Sode kogust). Rottermanni soolalaos näitus "Kodu, kallis kodu". Viljandi muuseumis on väljas EKA nahakunsti osakonna tööd aastaist 1917-2004 "Mälu ja mäng", Eesti lapitööseltsi näitus, Viljandi maagümnaasiumi kunstistuudio näitus "Jõulusokk". Eesti Meremuuseumis näitus"Klaas, fajanss ja portselan uppunud laevadelt"

UK National Data Centre archive of seismic recordings of (presumed) underground nuclear tests 1964-1996

Science.gov (United States)

Young, John; Peacock, Sheila

2016-04-01

The year 1996 has particular significance for forensic seismologists. This was the year when the Comprehensive Test Ban Treaty (CTBT) was signed in September at the United Nations, setting an international norm against nuclear testing. Blacknest, as a long time seismic centre for research into detecting and identifying underground explosions using seismology, provided significant technical advice during the CTBT negotiations. Since 1962 seismic recordings of both presumed nuclear explosions and earthquakes from the four seismometer arrays Eskdalemuir, Scotland (EKA), Yellowknife, Canada (YKA), Gauribidanur, India (GBA), and Warramunga, Australia (WRA) have been copied, digitised, and saved. There was a possibility this archive would be lost. It was decided to process the records and catalogue them for distribution to other groups and institutions. This work continues at Blacknest but the archive is no longer under threat. In addition much of the archive of analogue tape recordings has been re-digitised with modern equipment, allowing sampling rates of 100 rather than 20 Hz.

Nuclear and chemical data for life sciences

International Nuclear Information System (INIS)

Moumita Maiti; Indian Institute of Technology Roorkee, Roorkee, Uttarakhand

2013-01-01

Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

CERN Document Server

De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

International Nuclear Information System (INIS)

Wilbur, D. Scott

2011-01-01

This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

Sci-Thur AM: YIS – 01: New technologies for astatine-211 targeted alpha therapy research

Energy Technology Data Exchange (ETDEWEB)

Crawford, Jason; Yang, Hua; Schaffer, Paul; Ruth, Thomas [University of Victoria, Victoria, BC (Canada); TRIUMF, Vancouver, BC (Canada)

2016-08-15

Purpose: The short-range, densely ionizing α-particles emitted by {sup 211}At (t{sub 1/2}=7.2h) are well suited for the treatment of diffuse microscopic disease, using cancer targeting biomolecules. {sup 211}At availability is limited by the rarity of α-cyclotrons required for standard production. Image-based dosimetry is also limited for {sup 211}At, which emits low intensity X-rays. Our goal was to leverage state-of-the-art infrastructure at TRIUMF to produce and evaluate two related isotopes, {sup 211}Rn (t{sub 1/2}=14.6h, 73% decay to {sup 211}At) as a generator for {sup 211}At, and {sup 209}At (t{sub 1/2}=5.4h, X-ray/gamma-ray emitter) as a novel 211At surrogate for preclinical imaging studies. Methods: Produced by spallation of uranium with 480 MeV protons, mass separated ion beams of short-lived francium isotopes were implanted into NaCl targets where {sup 211}Rn or {sup 209}At were produced by radioactive decay, in situ. {sup 211}Rn was transferred to dodecane from which {sup 211}At was efficiently extracted and evaluated for clinical applicability. High energy SPECT/CT was evaluated for measuring {sup 209}At activity distributions in mice and phantoms. Results: Our small scale {sup 211}Rn/{sup 211}At generator system provided high purity {sup 211}At samples. The methods are immediately scalable to the level of radioactivity required for in vivo experiments with {sup 211}At. {sup 209}At-based high energy SPECT imaging was determined suitable for pursuing image-based dosimetry in mouse tumour models. In the future, we will utilize quantitative {sup 209}At-SPECT for image-based dose calculations. Conclusion: These early studies provided a foundation for future endeavours with {sup 211}At-based α-therapy. Canada is now significantly closer to clinical targeted α-therapy of cancer.

Reaction of aromatic diazonium salts with carrier-free radioiodine and astatine, evidence for complex formation

International Nuclear Information System (INIS)

Meyer, G.J.; Roessler, K.; Stoecklin, G.

1979-01-01

Systematic studies of the astatodiazoniation reaction and a comparison with iododediazoniation under comparable conditions are reported. The yields for all astatohalobenzenes and -toluenes were nearly constant and unaffected by the nature of the diazonium compound, its isomeric form, and the number of isomers used at the same time. Only astatofluorobenzenes were obtained at higher yields. An electron-transfer mechanism is proposed for dediazoniation at these low halide concentration levels. At sufficient thermal excitation levels the electron transfer leads to the dissociation of nitrogen, while the phenyl and halogen radicals recombine. The isomer distribution found for some of the derivatives from dediazoniation may also be due to steric effects

Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for alpha radionuclide therapy

International Nuclear Information System (INIS)

Ogawa, Kazuma; Mizuno, Yoshiaki; Washiyama, Kohshin; Shiba, Kazuhiro; Takahashi, Naruto; Kozaka, Takashi; Watanabe, Shigeki; Shinohara, Atsushi; Odani, Akira

2015-01-01

Introduction: Sigma receptors are overexpressed in a variety of human tumors, making them potential targets for radionuclide receptor therapy. We have previously synthesized and evaluated 131 I-labeled (+)-2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-[ 131 I]pIV], which has a high affinity for sigma receptors. Therefore, (+)-[ 131 I]pIV significantly inhibited tumor cell proliferation in tumor-bearing mice. In the present study, we report the synthesis and the in vitro and in vivo characterization of (+)-[ 211 At]pAtV, an 211 At-labeled sigma receptor ligand, that has potential use in alpha-radionuclide receptor therapy. Methods: The radiolabeled sigma receptor ligand (+)-[ 211 At]pAtV was prepared using a standard halogenation reaction generating a 91% radiochemical yield with 98% purity after HPLC purification. The partition coefficient of (+)-[ 211 At]pAtV was measured. Cellular uptake experiments and in vivo biodistribution experiments were performed using a mixed solution of (+)-[ 211 At]pAtV and (+)-[ 125 I]pIV; the human prostate cancer cell line DU-145, which expresses high levels of the sigma receptors, and DU-145 tumor-bearing mice. Results: The lipophilicity of (+)-[ 211 At]pAtV was similar to that of (+)-[ 125 I]pIV. DU-145 cellular uptake and the biodistribution patterns in DU-145 tumor-bearing mice at 1 h post-injection were also similar between (+)-[ 211 At]pAtV and (+)-[ 125 I]pIV. Namely, (+)-[ 211 At]pAtV demonstrated high uptake and retention in tumor via binding to sigma receptors. Conclusion: These results indicate that (+)-[ 211 At]pAtV could function as an new agent for alpha-radionuclide receptor therapy.

Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for alpha radionuclide therapy.

Science.gov (United States)

Ogawa, Kazuma; Mizuno, Yoshiaki; Washiyama, Kohshin; Shiba, Kazuhiro; Takahashi, Naruto; Kozaka, Takashi; Watanabe, Shigeki; Shinohara, Atsushi; Odani, Akira

2015-11-01

Sigma receptors are overexpressed in a variety of human tumors, making them potential targets for radionuclide receptor therapy. We have previously synthesized and evaluated (131)I-labeled (+)-2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-[(131)I]pIV], which has a high affinity for sigma receptors. Therefore, (+)-[(131)I]pIV significantly inhibited tumor cell proliferation in tumor-bearing mice. In the present study, we report the synthesis and the in vitro and in vivo characterization of (+)-[(211)At]pAtV, an (211)At-labeled sigma receptor ligand, that has potential use in alpha-radionuclide receptor therapy. The radiolabeled sigma receptor ligand (+)-[(211)At]pAtV was prepared using a standard halogenation reaction generating a 91% radiochemical yield with 98% purity after HPLC purification. The partition coefficient of (+)-[(211)At]pAtV was measured. Cellular uptake experiments and in vivo biodistribution experiments were performed using a mixed solution of (+)-[(211)At]pAtV and (+)-[(125)I]pIV; the human prostate cancer cell line DU-145, which expresses high levels of the sigma receptors, and DU-145 tumor-bearing mice. The lipophilicity of (+)-[(211)At]pAtV was similar to that of (+)-[(125)I]pIV. DU-145 cellular uptake and the biodistribution patterns in DU-145 tumor-bearing mice at 1h post-injection were also similar between (+)-[(211)At]pAtV and (+)-[(125)I]pIV. Namely, (+)-[(211)At]pAtV demonstrated high uptake and retention in tumor via binding to sigma receptors. These results indicate that (+)-[(211)At]pAtV could function as an new agent for alpha-radionuclide receptor therapy. Copyright © 2015 Elsevier Inc. All rights reserved.

XIX – XXI amžiaus ideologijos kritika: K. Marxas, F. Engelsas, S. Žižekas

OpenAIRE

Senūta, Povilas

2012-01-01

XIX ir ypač XX amžius pasižymėjo stipriomis ideologijomis, kurios ne tik keitė pasaulio ir žmonių gyvenimus, bet ir turėjo įtakos visoms vėlesnėms kartoms. Šio darbo tyrimo objektas – XIX – XXI amžiaus ideologijos kritika. Bandant suprasti pačias svarbiausias ideologijas, neišvengiamai tenka gilintis į marksizmo, kaip vieną iki šių dienų svarbiausią ideologiją ir pabandyti suprasti, kur slypi marksizmo fenomenas. Žinoma, čia neišvengiamai tenka kalbėti ir apie kitas ideologijas, tokias, ku...

Homme kell 19 algab EKA galeriis Norra eri väljapanek "(A guide to) constructing the universe"

Index Scriptorium Estoniae

2005-01-01

Kuraatoriduo Rakett koosseisus Karolin Tampere ja Ase Lovgren norra noorema kunsti ja muusikaga.12. III toimuva norra video- ja performance'i-õhtu esinejad loetletud, vt. ka lk. 24. Projekti II osa 19. märtsil Ku-Ku klubis (bändid ja dj-d)

"Art Plaza" vastab XXI sajandi kunstikõrgkooli nõuetele : EKA maja / Signe Kivi ; interv. R[eet] V[arblane

Index Scriptorium Estoniae

Kivi, Signe, 1957-

2008-01-01

Eesti Kunstiakadeemia rektor ja arhitektuurivõistluse žürii esimees Signe Kivi kunstiakadeemia uue hoone rahvusvahelise arhitektuurikonkursi võidutööst "Art Plaza" ( Taani AB Sea + Effekt). Hoone ehitus peaks algama 2009. a. sügistalvel, hoone valmima 2011. aastaks

211 At-labeled agents for alpha-immunotherapy: On the in vivo stability of astatine-agent bonds

OpenAIRE

Ayed , Tahra ,; Pilmé , Julien; Tézé , David; Bassal , Fadel ,; Barbet , Jacques ,; Chérel , Michel; Champion , Julie ,; Maurice , Rémi; Montavon , Gilles ,; Galland , Nicolas ,

2016-01-01

International audience; The application of 211 At to targeted cancer therapy is currently hindered by the rapid deastatination that occurs in vivo. As the deastatination mechanism is unknown, we tackled this issue from the viewpoint of the intrinsic properties of At-involving chemical bonds. An apparent correlation has been evidenced between in vivo stability of 211 At-labeled compounds and the AtÀR (R ¼ C, B) bond enthalpies obtained from relativistic quantum mechanical calculations. Further...

Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-211 Isolation

International Nuclear Information System (INIS)

Wilbur, Daniel Scott

2016-01-01

This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O'Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-year project with 1 year no-cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate 211 At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar 211 At capture (>95%) from 8M HCl solutions and release with conc. NH 4 OH (~50-80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of 211 At when loading [ 211 At]astatate appeared to be similar to that of [ 211 At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of 211 At on PEG columns was lower (e.g. 80-90%) from solutions of 8M HNO 3 , but higher capture rates (e.g. 99%) can be obtained when 10M HNO 3 is mixed with an equal quantity of 8M HCl; Addition of reductants to the 211 At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-automated 211 At isolation studies have been conducted with full-scale target dissolution and 211 At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO 3 was used (rather than HCl) for loading the 211 At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for 211 At separation from bismuth, which allow use of HNO 3 /HCl mixtures for loading and NaOH for eluting 211 At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: Biotinyl-3-[211At]astatoanilide

International Nuclear Information System (INIS)

Foulon, Catherine F.; Schoultz, Bent W.; Zalutsky, Michael R.

1997-01-01

Biotinyl-3-[ 211 At]astatoanilide ([ 211 At]AtBA) was prepared in more than 80% yield by destannylation. In vitro, [ 211 At]AtBA exhibited a high affinity for streptavidin, and was stable after incubation in human serum, cerebrospinal fluid and distilled water, whereas it was rapidly degraded in mouse serum. HPLC analysis showed that the main degradation pathway in mouse serum was the cleavage of [ 211 At]astatoaniline. In mice, [ 211 At]AtBA and its 125 I-labeled analogue cleared rapidly from most tissues; however, there was some evidence for dehalogenation of both tracers

"Green technology": Bio-stimulation by an electric field for textile reactive dye contaminated agricultural soil.

Science.gov (United States)

Annamalai, Sivasankar; Santhanam, Manikandan; Selvaraj, Subbulakshmi; Sundaram, Maruthamuthu; Pandian, Kannan; Pazos, Marta

2018-05-15

The aim of the study is to degrade pollutants as well as to increase the fertility of agricultural soil by starch enhancing electrokinetic (EKA) and electro-bio-stimulation (EBS) processes. Starch solution was used as an anolyte and voltage gradient was about 0.5V/cm. The influence of bacterial mediated process was evaluated in real contaminated farming soil followed by pilot scale experiment. The in-situ formation of β-cyclodextrin from starch in the treatments had also influence on the significant removal of the pollutants from the farming soil. The conductivity of the soil was effectively reduced from 15.5dS/m to 1.5dS/m which corroborates well with the agricultural norms. The bio-stimulation was confirmed by the increase of the phosphorus content in the treated soil. Finally, phytotoxicity assays demonstrated the viability of the developed technique for soil remediation because plant germination percentage was higher in the treated soil in comparison to untreated soil. Copyright © 2017 Elsevier B.V. All rights reserved.

211At-labelling of polymer particles for radiotherapy: synthesis, purification and stability

International Nuclear Information System (INIS)

Larsen, R.H.; Hassfjell, S.P.; Hoff, P.; Alstad, J.; Bjoergum, J.

1993-01-01

Cyclotron-produced 211 At was distilled from a Bi metal target and coupled to N-succinimidyl-3-(trimethylstannyl)benzoate. The resulting N-succinimidyl-3-( 211 At)astatobenzoate was thereafter coupled to aminated monosized polymer particles with a diameter of 1.8 μm. The total time elapsed from the end of the cyclotron irradiation until the final product was prepared was about 2.5 hours. From 23 to 51% of the target activity at the end of bombardment was measured in the final conjugate. Solid-liquid extraction purification of the astatinated intermediate, using Sep-pak columns (Waters), gave more reproducible yields in the final conjugation step. The 211 At-labelled particles were incubated with fetal calf serum, human serum and human full blood at room temperature. The 211 At activity on the particles was measured before and after three times washing at 4, 24 and 48 hours. The stability was not significantly different from 100% for all media and for all time points. This indicates that 211 At-labelled particles can be stable under in vivo conditions, and may thereby be a promising agent for intracavitary radiotherapy on free-floating cancer cells or surface fixed cells. (Author)

Tinjauan Yuridis Perjanjian Kerjasama Dalam Penjualan Voucher Hotel Antara PT. Eka Sukma Tour Dengan Hotel J.W. Marriot Medan

OpenAIRE

Sukma, Rio Adrian

2012-01-01

Agreement is an action in which one or more people bind himself/themselves to one or more people. Law recognizes a person's autonomy right to freely make agreements with any one and to specify the content of the agreement known as the principle of freedom of contract. But, in fact, in a contractual agreement, the clause has been unilaterally determined by the first party. Whereas, the second party, of course, has to comply with the provisions stated in the contract, that there ...

Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-­211 Isolation

Energy Technology Data Exchange (ETDEWEB)

Wilbur, Daniel Scott [Univ. of Washington, Seattle, WA (United States)

2016-07-19

This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O’Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-­year project with 1 year no-­cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate ²¹¹At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-­Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar ²¹¹At capture (>95%) from 8M HCl solutions and release with conc. NH₄OH (~50-­80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of ²¹¹At when loading [²¹¹At]astatate appeared to be similar to that of [²¹¹At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of ²¹¹At on PEG columns was lower (e.g. 80-­90%) from solutions of 8M HNO₃, but higher capture rates (e.g. 99%) can be obtained when 10M HNO₃ is mixed with an equal quantity of 8M HCl; Addition of reductants to the ²¹¹At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-­Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-­automated ²¹¹At isolation studies have been conducted with full-scale target dissolution and ²¹¹At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO₃ was used (rather than HCl) for loading the ²¹¹At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for ²¹¹At separation from bismuth, which allow use of HNO₃/HCl mixtures for loading and NaOH for eluting ²¹¹At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

Alpha particle emitters in medicine

International Nuclear Information System (INIS)

Fisher, D.R.

1989-09-01

Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ( 211 At) and natural bismuth-212 ( 212 Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ( 223 Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

The in vivo fate of a 211At labelled monoclonal antibody with known specificity in a murine system

International Nuclear Information System (INIS)

Vaughan, A.T.M.; Bateman, W.J.; Fisher, D.R.

1982-01-01

A monoclonal antibody reactive against the human transferrin receptor has been labelled with the alpha and X ray emitting isotope Astatine 211. The labelling procedure does not affect the ability of the product to bind to the transferrin receptor on the human leukemic cell line HL60. Using a direct binding assay, 211 At labelled antibody can be specifically inhibited from binding to its target cells by excess unlabelled antibody. Furthermore, the binding inhibition demonstrated in this system correlates to enhanced clonogenic survival of these cells, indicating that very few atoms of 211 At/cell are required for cell death. Data obtained from labelled antibody injected into mice show that the labelled product in serum retains the ability to bind to HL60 cells in vitro, although tissue distributions of the injected activity implies that some of the radiolabel is lost from the protein. Despite this loss of label, preliminary experiments on the localization of labelled antibody to HL60 cells growing s/c in nude mice show that tumor tissue has a higher specific activity than all other tissues, other than blood, after 12 hours. This suggests that further work on the nature of label degradation in vivo is warranted in the context of potential therapeutic and diagnostic studies

Suvine Tallinn on täis head tarbekunsti, ka harrastajad on aktiivsed / Andri Ksenofontov

Index Scriptorium Estoniae

Ksenofontov, Andri, 1962-

2005-01-01

Andres ja Katja Koorti korraldatud kobarnäitus "18 tuba" Sakala t. 9 majas, Adolfas Shaulyse ja Mari Relo-Shaulyse näitus "Viva la vida!" A-galeriis, Piret Räni näitus "Hello friend - are you impotent?" EKA galeriis, Tiina Piisangu tööd köitekunstinäitusel "Scripta manent III. Maailma parim asi" Eesti Tarbekunsti- ja Disainimuuseumis, Kristiina Kalistru ja Silvia Kelle tööd Kullo galeriis, Anne Türni tööd ja väljapanek Lühikese jala galeriis, Eesti Keraamikute Liidu puupõletustehnikas teostatud tööde näitus arhitektuurimuuseumis, Thomas Häntzscheli fotode näitus ArtDepoos, Angelika Kauffmanni näitus Kadrioru Kunstimuuseumis, Adam Greeni ja Simona Dell'Agli näitus "Tekkimine" Tallinna Linnagaleriis, Merike Estna maalinäitus "The Sexiest Girl, Pussycat, the Happiest Girl and Two Loverabbits" Haus galeriis, Monica del Norte maalinäitus "Lugupilt" G-galeriis, Päivi Randveri näitus "Reisid kosmosesse" Draakoni galeriis, Kelli Valk Kagovere näitus "Kõik muutub" Ühispanga galeriis, Toomas Sarapuu näitus "Deebetkaart" Tallinna Kunstihoone galeriis jm.

The radiolabeled monoclonal antibodies in immunoscintigraphy and radioimmunotherapy: current state and perspectives

International Nuclear Information System (INIS)

Chatal, J. F.

2000-01-01

The antibodies can be satisfactorily labelled with technitium-99 m or indium-111 for tumor immunoscintigraphy. The immunoscintigraphy is not useful for the primary tumor diagnosis. It can be useful for the diagnosis of the some cancer extension and for recurrent tumor visualization. The immunoscintigraphy is widely competed with Positron Emission Tomography (PET) which gives accurate results. In the future the immunoscintigraphy, in pre-therapeutic stage, contribute to the estimation of the dose delivered to the tumor and to normal organs for adopting or not a radioimmunotherapy. The antibodies can also be labeled with Iodine-131 for an application in radioimmunotherapy (RIT). The RIT is efficient in the non-Hodgkin's lymphoma treatment because of their great radiosensitivity. Until now the results have been very modest in solid tumor treatment but methodological and biotechnological progresses have to improve the efficiency especially for the small tumors. In the future iodine-131 which requires the confinement (very expensive) of patients will be substituted by yttrium-90 beta emitter, more energetic than iodine-131 and can be injected in walking case. In the long term, the alpha emitter radionuclides (astatine-211 or bismuth-213) can be used for hematologic cancer treatment. In conclusion the future of radiolabeled monoclonal antibodies is essentially therapeutic. The radioimmunotherapy associated to the chemotherapy give promising perspectives for the radiosensitive cancer treatment and in general small solid tumor treatment (F.M.)

On the theory of time dilation in chemical kinetics

Science.gov (United States)

Baig, Mirza Wasif

2017-10-01

The rates of chemical reactions are not absolute but their magnitude depends upon the relative speeds of the moving observers. This has been proved by unifying basic theories of chemical kinetics, which are transition state theory, collision theory, RRKM and Marcus theory, with the special theory of relativity. Boltzmann constant and energy spacing between permitted quantum levels of molecules are quantum mechanically proved to be Lorentz variant. The relativistic statistical thermodynamics has been developed to explain quasi-equilibrium existing between reactants and activated complex. The newly formulated Lorentz transformation of the rate constant from Arrhenius equation, of the collision frequency and of the Eyring and Marcus equations renders the rate of reaction to be Lorentz variant. For a moving observer moving at fractions of the speed of light along the reaction coordinate, the transition state possess less kinetic energy to sweep translation over it. This results in the slower transformation of reactants into products and in a stretched time frame for the chemical reaction to complete. Lorentz transformation of the half-life equation explains time dilation of the half-life period of chemical reactions and proves special theory of relativity and presents theory in accord with each other. To demonstrate the effectiveness of the present theory, the enzymatic reaction of methylamine dehydrogenase and radioactive disintegration of Astatine into Bismuth are considered as numerical examples.

Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

Energy Technology Data Exchange (ETDEWEB)

Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

2016-08-01

The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

Radiobromination of humanized anti-HER2 monoclonal antibody trastuzumab using N-succinimidyl 5-bromo-3-pyridinecarboxylate, a potential label for immunoPET

Energy Technology Data Exchange (ETDEWEB)

Mume, Eskender [Organic Chemistry, Department of Chemistry, Uppsala University, S-751 24 Uppsala (Sweden); Orlova, Anna [Affibody AB, S-161 02 Bromma (Sweden); Malmstroem, Per-Uno [Division of Urology, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Lundqvist, Hans [Unit of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, S-751 85 Uppsala (Sweden); Sjoeberg, Stefan [Organic Chemistry, Department of Chemistry, Uppsala University, S-751 24 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, S-751 85 Uppsala (Sweden)]. E-mail: vladimir.tolmachev@bms.uu.se

2005-08-01

Combining the specificity of radioimmunoscintigraphy and the high sensitivity of PET in an in vivo detection technique could improve the quality of nuclear diagnostics. Positron-emitting nuclide {sup 76}Br (T {sub 1/2}=16.2 h) might be a possible candidate for labeling monoclonal antibodies (mAbs) and their fragments, provided that the appropriate labeling chemistry has been established. For internalizing antibodies, such as the humanized anti-HER2 monoclonal antibody, trastuzumab, radiobromine label should be residualizing, i.e., ensuring that radiocatabolites are trapped intracellularly after the proteolytic degradation of antibody. This study evaluated the chemistry of indirect radiobromination of trastuzumab using N-succinimidyl 5-(tributylstannyl)-3-pyridinecarboxylate. Literature data indicated that the use of this method provided residualizing properties for iodine and astatine labels on some antibodies. An optimized 'one-pot' procedure produced an overall labeling efficiency of 45.5{+-}1.2% over 15 min. The bromine label was stable under physiological and denaturing conditions. The labeled trastuzumab retained its capacity to bind specifically to HER2-expressing SKOV-3 ovarian carcinoma cells in vitro (immunoreactivity more than 75%). However, in vitro cell test did not demonstrate that the radiobromination of trastuzumab using N-succinimidyl 5-bromo-3-pyridinecarboxylate improves cellular retention of radioactivity in comparison with the use of N-succinimidyl 4-bromobenzoate.

Gas phase chemical studies of superheavy elements using the Dubna gas-filled recoil separator - Stopping range determination

International Nuclear Information System (INIS)

Wittwer, D.; Abdullin, F.Sh.; Aksenov, N.V.; Albin, Yu.V.; Bozhikov, G.A.; Dmitriev, S.N.; Dressler, R.; Eichler, R.; Gaeggeler, H.W.; Henderson, R.A.; Huebener, S.; Kenneally, J.M.; Lebedev, V.Ya.; Lobanov, Yu.V.; Moody, K.J.; Oganessian, Yu.Ts.; Petrushkin, O.V.; Polyakov, A.N.; Piguet, D.; Rasmussen, P.

2010-01-01

Currently, gas phase chemistry experiments with heaviest elements are usually performed with the gas-jet technique with the disadvantage that all reaction products are collected in a gas-filled thermalisation chamber adjacent to the target. The incorporation of a physical preseparation device between target and collection chamber opens up the perspective to perform new chemical studies. But this approach requires detailed knowledge of the stopping force (STF) of the heaviest elements in various materials. Measurements of the energy loss of mercury (Hg), radon (Rn), and nobelium (No) in Mylar and argon (Ar) were performed at low kinetic energies of around (40-270) keV per nucleon. The experimentally obtained values were compared with STF calculations of the commonly used program for calculating stopping and ranges of ions in matter (SRIM). Using the obtained data points an extrapolation of the STF up to element 114, eka-lead, in the same stopping media was carried out. These estimations were applied to design and to perform a first chemical experiment with a superheavy element behind a physical preseparator using the nuclear fusion reaction 244 Pu( 48 Ca; 3n) 289 114. One decay chain assigned to an atom of 285 112, the α-decay product of 289 114, was observed.

Galeriid - Tallinna kunstisoonel / Andri Ksenofontov

Index Scriptorium Estoniae

Ksenofontov, Andri, 1962-

2005-01-01

Valgusfestival Tallinnas, Angelika Schneideri joonistuste näitus "Valgest mustani" Estonia Kontserdisaali fuajees, Liina Vedleri näitus "Raskolnikova saar" EKA galeriis, Maria Valdma näitus "Fiktsioonid" Tallinna Linnagaleriis, Eveli Variku näitus "Armuke" Kunstihoone galeriis, Tarmo Roosimöldri näitus "Paus" ning Kaarina Ormio, Jaan Pärnamäe ja Elin T. Sorenseni installatsioon "Mäng" G-galeriis, šveitsi-soome fotograafi Peter Strebeli näitus "Maroko Anti-Atlase mäestiku motiivid" Kiek in de Kökis, Jaan Künnapi Tallinna panoraam näitusel "Tallinn, inimesed ja linn 1878-2002" Raevangla Fotomuuseumis, TPÜ üliõpilaste fotonäitus "Fotofinish" fotokeldris Lee, TPÜ kunstiosakonna üliõpilaste näitus "Tehnika ja lüürika" Viviann Napa galeriis, näitus "Juugendstiil Lätis", Pille Kivihalli, Maarja Unduski ja Tiina Piisangu näitus "Altar raamatule" rahvusraamatukogus, Toomas Keldri mälestusnäitus disaini- ja arhitektuurigaleriis, Irina Ishina näitus Vene saatkonna galeriis, Vladimir Baciu näitus Haus galeriis, Vassili Gretshko näitus Artline'i galeriis, Jana Wiebe ja Tjika Rebase "Surnuaia kogumik vol. 1" Hobusepea galeriis, Kadi Kurema näitus "Imeasjad" Ühispanga galeriis ja "Pisiasjad" Galeriis 36

Gallium--A smart metal

Science.gov (United States)

Foley, Nora; Jaskula, Brian W.

2013-01-01

Gallium is a soft, silvery metallic element with an atomic number of 31 and the chemical symbol Ga. The French chemist Paul-Emile Lecoq de Boisbaudran discovered gallium in sphalerite (a zinc-sulfide mineral) in 1875 using spectroscopy. He named the element "gallia" after his native land of France (formerly Gaul; in Latin, Gallia). The existence of gallium had been predicted in 1871 by Dmitri Mendeleev, the Russian chemist who published the first periodic table of the elements. Mendeleev noted a gap in his table and named the missing element "eka-aluminum" because he determined that its location was one place away from aluminum in the table. Mendeleev thought that the missing element (gallium) would be very much like aluminum in its chemical properties, and he was right. Solid gallium has a low melting temperature (~29 degrees Celsius, or °C) and an unusually high boiling point (~2,204 °C). Because of these properties, the earliest uses of gallium were in high-temperature thermometers and in designing metal alloys that melt easily. The development of a gallium-based direct band-gap semiconductor in the 1960s led to what is now one of the most well-known applications for gallium-based products--the manufacture of smartphones and data-centric networks.

Radiochemical search for neutron-rich isotopes of element 107

International Nuclear Information System (INIS)

Schaedel, M.

1987-01-01

Recent mass calculations have indicated that there is a region of deformed nuclei around neutron number N=162 that is especially stable against spontaneous fission. Barrier heights of about 5 MeV for Z = 107 nuclides can be extrapolated. To search for new, neutron-rich isotopes of element 107 in radiochemical experiments with 254 Es as a target an on-line chemical separation of element 107 (EKA-Rhenium), especially from the actinide elements is needed. An on-line gas-phase chemistry was developed with the homolog Re based on the volatility of the oxide which is transported in an O 2 containing atmosphere along a temperature gradient in a quartz tube and is condensed onto a thin Ta coated Ni-foil. The authors applied this technique in two series of experiments with their rotating wheel on-line gas-phase chemistry apparatus at the 88-inch cyclotron where they irradiated 254 Es as a target with 93 MeV and 96 MeV 16 O ions to search for 266 107. The assignment of the observed alpha events between 8 and 9 MeV to possibly (1) non actinide contaminants like 212 Po, (2) known isotopes of heavy elements like 261 105, or (3) a new isotope will be discussed

[Eating habits of a group of professional volleyball players].

Science.gov (United States)

Gacek, Maria

2011-01-01

The aim of the research was an analysis of the eating habits of professional volleyball players according to their sex and age. The research has been carried out on a group of 210 men players and women players at the age of 13-25, representatives of sports clubs in Ostrołeka, Myślenice, Bydgoszcz and Warszawa. The research has revealed a limited realisation of rational diets by both men and women players. The most common mistakes made by them include a smaller number of meals during the day than recommended (especially among men), taking up training on empty stomach and insufficient frequency of consumption of dairy products, fish, vegetables and fruit. The research has also revealed excessive consumption of sweets, sweet sparkling drinks and fast food (mainly among men). The examined players to some extent only apply regular strategies of rehydration of their organisms. A high percentage of them do not pay attention to supplementation of liquids after an effort or they drink a lot of liquids at one time. The most frequently chosen drinks were mineral water and isotonic drinks. Supplementation was applied by a small percentage of the players, mainly men, who most often chose vitamins, Izostar, creatine, L-carnitine and HMB.

Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

Energy Technology Data Exchange (ETDEWEB)

Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

2011-01-15

Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

Development and radiotherapeutic application of 211At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

International Nuclear Information System (INIS)

Adelstein, S.J.; Zalutsky, M.; Bloomer, W.

1981-01-01

This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of 131 I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitters, 211 At appears most promising for therapeutic applications because, (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides, (2) it has a half-life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells due to degradation of the label over time, (3) it can be produced conveniently using a cyclotron, and (4) alpha emission is associated with 100% of its decays with no accompanying beta emission. In the past year the evaluation of an astatine-tellurium colloid as an agent for the destruction of malignant ascites has been completed. The therapeutic efficacy of 211 At-tellurium colloid has been compared with that of several beta-emitting radiocolloids. Studies on the application of monoclonal antibodies as carriers for selective delineation and destruction of malignant cell populations have also been initiated

Development and radiotherapeutic application of /sup 211/At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

Energy Technology Data Exchange (ETDEWEB)

Adelstein, S.J.; Zalutsky, M.; Bloomer, W.

1981-01-01

This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of /sup 131/I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitters, /sup 211/At appears most promising for therapeutic applications because, (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides, (2) it has a half-life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells due to degradation of the label over time, (3) it can be produced conveniently using a cyclotron, and (4) alpha emission is associated with 100% of its decays with no accompanying beta emission. In the past year the evaluation of an astatine-tellurium colloid as an agent for the destruction of malignant ascites has been completed. The therapeutic efficacy of /sup 211/At-tellurium colloid has been compared with that of several beta-emitting radiocolloids. Studies on the application of monoclonal antibodies as carriers for selective delineation and destruction of malignant cell populations have also been initiated.

Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

International Nuclear Information System (INIS)

Nestor, Marika; Sundstroem, Magnus; Anniko, Matti; Tolmachev, Vladimir

2011-01-01

Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ( 211 At-cMAb U36). Effects on 211 At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with 211 At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced 211 At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

Proceedings of transuranium elements

International Nuclear Information System (INIS)

Anon.

1992-01-01

The identification of the first synthetic elements was established by chemical evidence. Conclusive proof of the synthesis of the first artificial element, technetium, was published in 1937 by Perrier and Segre. An essential aspect of their achievement was the prediction of the chemical properties of element 43, which had been missing from the periodic table and which was expected to have properties similar to those of manganese and rhenium. The discovery of other artificial elements, astatine and francium, was facilitated in 1939-1940 by the prediction of their chemical properties. A little more than 50 years ago, in the spring of 1940, Edwin McMillan and Philip Abelson synthesized element 93, neptunium, and confirmed its uniqueness by chemical means. On August 30, 1940, Glenn Seaborg, Arthur Wahl, and the late Joseph Kennedy began their neutron irradiations of uranium nitrate hexahydrate. A few months later they synthesized element 94, later named plutonium, by observing the alpha particles emitted from uranium oxide targets that had been bombarded with deuterons. Shortly thereafter they proved that is was the second transuranium element by establishing its unique oxidation-reduction behavior. The symposium honored the scientists and engineers whose vision and dedication led to the discovery of the transuranium elements and to the understanding of the influence of 5f electrons on their electronic structure and bonding. This volume represents a record of papers presented at the symposium

Cancer therapy with alpha-emitters labeled peptides.

Science.gov (United States)

Dadachova, Ekaterina

2010-05-01

Actively targeted alpha-particles offer specific tumor cell killing action with less collateral damage to surrounding normal tissues than beta-emitters. During the last decade, radiolabeled peptides that bind to different receptors on the tumors have been investigated as potential therapeutic agents both in the preclinical and clinical settings. Advantages of radiolabeled peptides over antibodies include relatively straightforward chemical synthesis, versatility, easier radiolabeling, rapid clearance from the circulation, faster penetration and more uniform distribution into tissues, and less immunogenicity. Rapid internalization of the radiolabeled peptides with equally rapid re-expression of the cell surface target is a highly desirable property that enhances the total delivery of these radionuclides into malignant sites. Peptides, such as octreotide, alpha-melanocyte-stimulating hormone analogues, arginine-glycine-aspartic acid-containing peptides, bombesin derivatives, and others may all be feasible for use with alpha-emitters. The on-going preclinical work has primarily concentrated on octreotide and octreotate analogues labeled with Bismuth-213 and Astatine-211. In addition, alpha-melanocyte-stimulating hormone analogue has been labeled with Lead-212/Bismuth-212 in vivo generator and demonstrated the encouraging therapeutic efficacy in treatment of experimental melanoma. Obstacles that continue to obstruct widespread acceptance of alpha-emitter-labeled peptides are primarily the supply of these radionuclides and concerns about potential kidney toxicity. New sources and methods for production of these medically valuable radionuclides and better understanding of mechanisms related to the peptide renal uptake and clearance should speed up the introduction of alpha-emitter-labeled peptides into the clinic. Copyright 2010 Elsevier Inc. All rights reserved.

Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin

International Nuclear Information System (INIS)

Demartis, S.; Tarli, L.; Neri, D.; Borsi, L.; Zardi, L.

2001-01-01

Angiogenesis is a characteristic feature of many aggressive tumours and other disorders. Antibodies capable of binding to new blood vessels, but not to mature vessels, could be used as selective targeting agents for immunoscintigraphic and radioimmunotherapeutic applications. Here we show that scFv(L19), a recombinant human antibody fragment with sub-nanomolar affinity for the ED-B domain of fibronectin, a marker of angiogenesis, can be stably labelled with iodine-125 and astatine-211 with full retention of immunoreactivity, using a trimethyl-stannyl benzoate bifunctional derivative. Biodistribution studies in mice bearing two different types of tumour grafted subcutaneously, followed by ex vivo micro-autoradiographic analysis, revealed that scFv(L19) rapidly localises around tumour blood vessels, but not around normal vessels. Four hours after intravenous injection of the stably radioiodinated scFv(L19), tumour to blood ratios were 6:1 in mice bearing the F9 murine teratocarcinoma and 9:1 in mice bearing an FE8 rat sarcoma. As expected, all other organs (including kidney) contained significantly less radioactivity than the tumour. Since the ED-B domain of fibronectin has an identical sequence in mouse and man, scFv(L19) is a pan-species antibody and the results presented here suggest clinical utility of radiolabelled scFv(L19) for the scintigraphic detection of angiogenesis in vivo. Furthermore, it should now be possible to investigate scFv(L19) for the selective delivery of 211 At to the tumour neovasculature, causing the selective death of tumour endothelial cells and tumour collapse. (orig.)

Microbiological and chemical profiles of elephant grass inoculated with and without Lactobacillus plantarum and Pediococcus acidilactici.

Science.gov (United States)

Shah, Assar Ali; Xianjun, Yuan; Zhihao, Dong; Junfeng, Li; Sao, Tao

2018-03-01

The study was conducted to evaluate the microbiological and chemical profiles of elephant grass inoculated with and without different wild strains of lactic acid bacteria. Silage was prepared of four treatments and one control with three replicates as control (EKC, adding 2 ml/kg sterilizing water), Lactobacillus plantarum (USA commercial bacteria) (EKP), Lactobacillus plantarum (EKA), Pediococcus acidilactici (EKB), and Pediococcus acidilactici (SKD) isolated from King grass. Silage were prepared using polyethylene terephthalate bottles, and incubated at room temperature for different ensiling days. The pH and acetic acid (AA) were significantly (P < 0.05) reduced and lactic acid (LA), butyric acid (BA), and ethanol were significantly increased (P < 0.05) at 3, 5, 7, and 14 days in treatment groups as compared to control. Water-soluble carbohydrate (WSC) and NH 3 -N concentration was not affected at days 3, 5, and 7, but significantly (P < 0.05) reduced at 14 days in treatment groups as compared to control. The LA, BA, and ethanol were significantly (P < 0.05) increased and AA, WSC NH 3 -N, and yeast were significantly (P < 0.05) decreased at 30 days of ensiling in treatment groups as compared to control. It is recommended that the inoculation of LAB could improve the fermentation quality of elephant grass silage and further effort is needed to evaluate these effects on silage produced on farm scale and on animal production performance.

Implementation of K-Means Clustering Method for Electronic Learning Model

Science.gov (United States)

Latipa Sari, Herlina; Suranti Mrs., Dewi; Natalia Zulita, Leni

2017-12-01

Teaching and Learning process at SMK Negeri 2 Bengkulu Tengah has applied e-learning system for teachers and students. The e-learning was based on the classification of normative, productive, and adaptive subjects. SMK Negeri 2 Bengkulu Tengah consisted of 394 students and 60 teachers with 16 subjects. The record of e-learning database was used in this research to observe students’ activity pattern in attending class. K-Means algorithm in this research was used to classify students’ learning activities using e-learning, so that it was obtained cluster of students’ activity and improvement of student’s ability. Implementation of K-Means Clustering method for electronic learning model at SMK Negeri 2 Bengkulu Tengah was conducted by observing 10 students’ activities, namely participation of students in the classroom, submit assignment, view assignment, add discussion, view discussion, add comment, download course materials, view article, view test, and submit test. In the e-learning model, the testing was conducted toward 10 students that yielded 2 clusters of membership data (C1 and C2). Cluster 1: with membership percentage of 70% and it consisted of 6 members, namely 1112438 Anggi Julian, 1112439 Anis Maulita, 1112441 Ardi Febriansyah, 1112452 Berlian Sinurat, 1112460 Dewi Anugrah Anwar and 1112467 Eka Tri Oktavia Sari. Cluster 2:with membership percentage of 30% and it consisted of 4 members, namely 1112463 Dosita Afriyani, 1112471 Erda Novita, 1112474 Eskardi and 1112477 Fachrur Rozi.

Preparation and in vivo evaluation of radioiodinated closo-decaborate(2-) derivatives to identify structural components that provide low retention in tissues

International Nuclear Information System (INIS)

Wilbur, D. Scott; Chyan, M.-K.; Hamlin, Donald K.; Perry, Matthew A.

2010-01-01

Introduction: In vivo deastatination of 211 At-labeled biomolecules can severely limit their use in endoradiotherapy. Our studies have shown that the use of closo-decaborate(2-) moiety for 211 At-labeling of biomolecules provides high in vivo stability towards deastatination. However, data from those studies have also been suggestive that some astatinated closo-decaborate(2-) catabolites may be retained in tissues. In this study, we investigated the in vivo distributions of several structurally simple closo-decaborate(2-) derivatives to gain information on the effects of functional groups if catabolites are released into the blood system from the carrier biomolecule. Methods: Thirteen closo-decaborate(2-) derivatives were synthesized and radioiodinated for evaluation. Tissue concentrations of the radioiodinated compounds were obtained in groups of five mice at 1 and 4 h postinjection (pi). Dual-label ( 125 I and 131 I) experiments permitted evaluation of two compounds in each set of mice. Results: All of the target compounds were readily synthesized. Radioiodination reactions were conducted with chloramine-T and Na[ 125/131 I]I in water to give high yields (75-96%) of the desired compounds. Biodistribution data at 1 and 4 h pi (representing catabolites released into the blood system) showed small differences in tissue concentrations for some compounds, but large differences for others. The results indicate that formal (overall) charge on the compounds could not be used as a predictor of tissue localization or retention. However, derivatives containing carboxylate groups generally had lower tissue concentrations. Acid cleavable hydrazone functionalities appeared to be the best candidates for further study. Conclusions: Further studies incorporating hydrazone functionalities into pendant groups for biomolecule radiohalogenation are warranted.

Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

International Nuclear Information System (INIS)

Larsen, R.H.; Bruland, O.S.; Hoff, P.; Alstad, J.; Lindmo, T.; Rofstad, E.K.

1994-01-01

The potential usefulness of α-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) 211 At-TP-3 of different specific activities, (b) 211 At-labeled bovine serum albumin (BSA), (c) free 211 At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, 211 At-BSA or free 211 At. The D o 's were lower for free 211 At than for 211 At-BSA. The survival curves for 211 At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to 211 At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to 211 At-TP-3 treatment was the antigen expression. Cell inactivation after 211 At-TP-3 treatment increased substantially with increasing specific activity of the 211 At-TP-3. At high specific activities, the cytotoxic effect of 211 At-TP-3 was significantly higher than that of 211 At-BSA. In conclusion, 211 At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs

Final Report

Energy Technology Data Exchange (ETDEWEB)

Sujit Banerjee

2005-12-15

Contaminants present in paper recycling mills can degrade product properties and can also lead to substantial downtime. Of these, adhesive material such as hot melts and pressure sensitive adhesives are especially troublesome. These are known as “ stickies ” and their handling and re- moval requires process equipment such as screens and cleaners as well as chemical additives. In the preceding phase of the project we demonstrated that firing an underwater spark in a tank of stock reduces the tack of the stickies and reduces their impact. The present phase was to demon- strate the technology in full-scale trials, address any issues that might arise, and commercialize the process. Trials were run at the Appleton papers mill in West Carrollton, OH, the Graphics Packag- ing mill at Kalamazoo, MI, Stora Enso mills at Duluth, MN, and Wisconsin Rapids, WI, and the Jackson Paper mill at Sylva, NC. It was shown that the sparker not only detackified stickies but also increased the efficiency of their removal by centrifugal cleaners, improved the effectiveness of dissolved air flotation, and increased the efficiency of flotation deinking. It is estimated that the sparker improves the efficiency of hydrocyclone cleaner, deinking cells and dissolved and dispersed air flotation units by 10-15%. This translates to a corresponding energy benefit in operating these units. The technology has been licensed to Eka Chemicals, a division of Akzo Nobel.

The effects of planting media and leaf fertilizers on the growth of jamrud orchid (Dendrobium macrophyllum A. Rich.

Directory of Open Access Journals (Sweden)

I GEDE TIRTA

2006-01-01

Full Text Available Jamrud orchid (Dendrobium macrophyllum A. Rich. have attractive flowers which make the orchid become one of high economic ornamental plants. The orchid is one of endangered species. Its growth is slow, however appropriate planting media and leaf fertilizers can improve the growth of the orchid. The experiment was conducted from February to June 2003, at “Eka Karya” Bali Botanic Garden. The design used in the experiment was completely randomized block with two treatments and four replicates. The first factor were six kinds of planting medias (roots of C. contaminans, roots of Asplenium nidus, charcoal, roots of C. contaminans+roots of A. nidus, roots of C. contaminans+charcoal and roots of A. nidus+charcoal. The second factor were four kinds of fertilizers (plant catalyst, super bionik, inabio and subur inti persada and one treatment without fertilizer. The results of experiment showed that the interaction between planting medias and leaf fertilizers significantly affected increment of plant height at 12, 14, 16 and 18 weeks after planting, of leaf number at 14, 16 and 18 weeks after planting, of root length, of plant fresh weight and oven dry weight. Treatment of C. contaminans roots and of A. nidus roots combined with inabio fertilizer produced the highest vegetative growth. This treatment increased the total oven dry weight of plant (54.81%, increased the weight of plant (67.48%, of root length (41.63%, of total leaf number (70.73%, of plant height (59.01% and bud number (72.22% compared with treatment without fertilizer in the same media.

Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology

International Nuclear Information System (INIS)

Bourgeois, M.

2007-05-01

The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the 131 iodine or the 90 yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

UJI VIABILITAS SERBUK SARI Hemerocallis fulva L. (Liliaceae SETELAH PENYIMPANAN PADA WAKTU DAN SUHU YANG BERBEDA

Directory of Open Access Journals (Sweden)

Ni Kadek Sari Dewi Handayani

2013-04-01

Full Text Available This study aims to determine the type of Hemerocallis fulva L. pollen, pollen viability and growth after storage at 280C, 40C, -200C, -800C temperature for 0-8 weeks. The study was conducted from January - March 2010. Pollen samples were taken from UPT. Botanical Gardens Plant Conservation 'Eka Karya’ Bali. Pollen storage and observations was carried out at the Laboratory of Plant Biotechnology and Development Structure, Biology Department, Faculty of Science, Udayana University. Viability test were conducted using hanging drop media and agar media with GA3. The results showed that type of Hemerocallis fulva L. pollen were: monosulkat, Prolate spheroiodal, (54.25 X 47.47, P/E: 1.14, Zono, colpate, reticulate. Fresh pollen viability on hanging drop media was 8.33%, decreased to 4% after storage at 4°C for one week and -20°C for 5 weeks. Whereas on agar media, control pollen has viability of 3.17% and increased at -20°C to become 11.67%. Mature pollen can be observed at the level of uninukleat, binukleat, and trinukleat. The development of pollen with the media hanging drop on the control has a long reed 115.94 ?m and length increased at 4 ° C with storage duration ie 256.39 weeks to 1 ?m, whereas on an agar medium + GA3 to control reed 149.82 ?m in length and at 28 ° C, 4 ° C, -20 ° C and -80 ° C respectively 94.73 ?m; 142.1 ?m; 95.53 ?m; 118.67 ?m at 1 week storage time.

Environmental and life cycle assessment of the Finnish Forest Research Institute's (Metla) research centre in Joensuu

International Nuclear Information System (INIS)

Haekkinen, T.; Wirtanen, L.

2006-05-01

The publication presents the results from the environmental assessment of Metla office building. The assessment was done according to the principles introduced in the so called EKA-methodology. The publication analyses the influence of the use of wood on the environmental impacts on building level paying attention to the use of resources and release of carbon dioxide emissions. Wooden structures were compared to corresponding concrete structures. The alternative structures were comparable in terms of structural capacity and thermal performance (U-values). The study covered the structural parts of the building while other building parts were excluded. The exclusion was justified because the choice of structural components did not essentially affect the quality and quantity of other products. The study focused on the production and procurement of building products and the building. The study did not consider the effects of assembling, in-situ construction, care and maintenance and demolition on the material flows and relative environmental impacts. The study only dealt with the physical building and did not consider the environmental impacts from the use of the building. On the basis of the results the environmental impacts caused by the wooden structures of the Metla office building are significantly smaller than those of the corresponding concrete structures. For example the assessed total release of CO 2 emissions for the wooden building is 320 000 kg, while the corresponding value for the concrete building is 800 000 kg CO 2 . The result can be explained on the basis of the low weight of the wooden structures compared to the weight of corresponding concrete structures. The total weight of the structural parts (building skeleton and envelope) of the Metla building is roughly 2000 tons while the total weight of the corresponding concrete structures is nearly 5000 tons. (orig.)

Radiostatine and radioiodine uptake characterization in sodium iodine symporter-expressing cell lines

International Nuclear Information System (INIS)

Petrich, T.; Helmeke, H.J.; Meyer, G.J.; Knapp, W.H.; Poetter, E.

2002-01-01

Full text: The sodium iodide symporter (NIS) has been recognized as an attractive target for cancer gene therapy. Here we investigated NIS-mediated transport of the high LET α-emitter astatine, 211 At, in comparison to radioiodine. A constitutive expression vector harbouring the human NIS cDNA was used in combination with reporter gene vectors for transient transfection of 13 different human cancer cell lines. Radioiodine uptake was measured as well as transfection efficiencies. Six stable NIS-expressing cell lines (3 derived from thyroid carcinomas, 2 colon carcinoma, 1 glioblastoma) were generated by antibiotic selection. NIS expression was monitored by immunohistochemistry and RT-PCR. Subsequently the radioastatine and radioiodine uptake characteristics of genetically modified cells were studied in comparison to the respective control cells. After xenotransplantation in nude mice in vivo tumor imaging by scintigraphy and biodistribution studies following organ removal were performed. Transient transfection of NIS cDNA led to high specific sodium perchlorate-sensitive radioiodine uptake in NIS-expressing cells that roughly correlates to transfection efficiencies. Similarly, stable NIS-expressing cell lines were able to concentrate high levels of radioiodine and in addition showed comparable transport capacity for radioastatine. Accumulation of 211 At was inhibited by sodium perchlorate like iodide uptake and displayed dependency an extracellular Na + - and I - -ions as well. Compared to wash-out experiments in cell culture the effective half life of radioiodine and radioastatine in vivo was significantly prolonged. Preliminary dose calculations by MIRD concepts indicated higher tumor radiation doses for 211 At compared to 131 I. Tumor cells of different origins transfected with the NIS-expression vector specifically and significantly take-up radioiodine and radioastatine in vitro and in vivo. The data provide direct evidence that the NIS efficiently transports

Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

Energy Technology Data Exchange (ETDEWEB)

Lyckesvärd, Madeleine Nordén, E-mail: madeleine.lyckesvard@oncology.gu.se [Department of Oncology, Sahlgrenska Academy, University of Gothenburg (Sweden); Delle, Ulla; Kahu, Helena [Department of Oncology, Sahlgrenska Academy, University of Gothenburg (Sweden); Lindegren, Sture [Department of Radiation Physics, Sahlgrenska Academy, University of Gothenburg (Sweden); Jensen, Holger [The PET and Cyclotron Unit Copenhagen University Hospital, Rigshospitalet (Denmark); Bäck, Tom [Department of Radiation Physics, Sahlgrenska Academy, University of Gothenburg (Sweden); Swanpalmer, John [Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg (Sweden); Elmroth, Kecke [Department of Oncology, Sahlgrenska Academy, University of Gothenburg (Sweden)

2014-07-15

Highlights: • We study DNA damage response to low-LET photons and high-LET alpha particles. • Cycling primary thyrocytes are more sensitive to radiation than stationary cells. • Influence of radiation quality varies due to cell cycle status of normal cells. • High-LET radiation gives rise to a sustained DNA damage response. - Abstract: Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ({sup 211}At), concentrated in the thyroid by the same mechanism as {sup 131}I [1], in cancer treatment has increased during recent years because of its high efficiency in inducing biological damage and beneficial dose distribution when compared to low-LET radiation. Most knowledge of the DNA damage response in thyroid is from studies using low-LET irradiation and much less is known of high-LET irradiation. In this paper we investigated the DNA damage response and biological consequences to photons from Cobolt-60 ({sup 60}Co) and alpha particles from {sup 211}At in normal primary thyrocytes of different cell cycle status. For both radiation qualities the intensity levels of γH2AX decreased during the first 24 h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to {sup 211}At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels. Increasing ratios of micronuclei per cell nuclei were seen up to 1 Gy {sup 211}At. We found that primary thyrocytes were much more sensitive to alpha particle exposure compared with low-LET photons. Calculations of the relative biological effectiveness yielded higher RBE for cycling cells compared with stationary cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative

α-Imaging Confirmed Efficient Targeting of CD₄₅-Positive Cells After ²¹¹At-Radioimmunotherapy for Hematopoietic Cell Transplantation

Energy Technology Data Exchange (ETDEWEB)

Frost, Sophia; Miller, Brian W.; Back, Tom; Santos, E. B.; Hamlin, Donald K.; Knoblaugh, E.; Frayo, Shani; Kenoyer, Aimee L.; Storb, Rainer; Press, O. W.; Wilbur, D. Scott; Pagel, John M.; Sandmaier, B. M.

2015-09-03

Alpha-radioimmunotherapy (α-RIT) targeting CD45 may substitute for total body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (MAb; CA12.10C12) protein dose for astatine-²¹¹(²¹¹At)-RIT, extending the analysis to include intra-organ ²¹¹At activity distribution and α-imaging-based small-scale dosimetry, along with imunohistochemical staining. Methods: Eight normal dogs were injected with either 0.75 (n=5) or 1.00 mg/kg (n=3) of ²¹¹At-B10-CA12.10C12 (11.5–27.6 MBq/kg). Two were euthanized and necropsied 19–22 hours postinjection (p.i.), and six received autologous HCT three days after ²¹¹At-RIT, following lymph node and bone marrow biopsies at 2–4 and/or 19 hours p.i. Blood was sampled to study toxicity and clearance; CD45 targeting was evaluated by flow cytometry. ²¹¹At localization and small scale dosimetry were assessed using two α-imaging : α-camera and iQID. Results: Uptake of ²¹¹At was highest in spleen (0.31–0.61 %IA/g), lymph nodes (0.02–0.16 %IA/g), liver (0.11–0.12 %IA/g), and marrow (0.06–0.08 %IA/g). Lymphocytes in blood and marrow were efficiently targeted using either MAb dose. Lymph nodes remained unsaturated, but displayed targeted ²¹¹At localization in T lymphocyte-rich areas. Absorbed doses to blood, marrow, and lymph nodes were estimated at 3.9, 3.0, and 4.2 Gy/210 MBq, respectively. All transplanted dogs experienced transient hepatic toxicity. Liver enzyme levels were temporarily elevated in 5 of 6 dogs; 1 treated with 1.00 mg MAb/kg developed ascites and was euthanized 136 days after HCT. Conclusion: ²¹¹At-anti-CD45 RIT with 0.75 mg MAb/kg efficiently targeted blood and marrow without severe toxicity. Dosimetry calculations and observed radiation-induced effects indicated that sufficient ²¹¹At-B10-CA12.10C12 localization was achieved for efficient conditioning for HCT.

Indirect Radiohalogenation of Targeting Proteins: Labelling Chemistry and Biological Characterisation

Energy Technology Data Exchange (ETDEWEB)

Orlova, Anna

2003-03-01

In about half of all newly diagnosed cancer cases, conventional treatment is not adequately curative, mainly due to the failure of conventional techniques to find and kill residual cells and metastases, which might consist of only a few malignant cells, without causing unacceptable complications to healthy tissue. To solve the problem a more selective delivery of cytotoxic substances to tumour cells is needed. The approach applied here is called 'tumour targeting' and implies the use of biomolecules that recognise specific molecular structures on the malignant cell surface. Such molecules are then used for a selective transport of toxic agents to the cancer cells. The use of radionuclides as cytotoxic substances has a number of advantages: 1) radiation does not cause severe resistance; 2) there is a cross-fire effect and 3) smaller amounts of nuclides are required than other cytotoxic substances to cause the same damage. Such an approach is called radionuclide tumour therapy. Several factors are important for the success of radionuclide therapy, such as the pharmacokinetics of the radiolabelled substance and its radiocatabolites, as well as the physical and chemical properties of the radiolabel used. Nuclear properties of the label should be consistent with the problem to be solved: primary diagnostics; quantification of pharmacokinetics and dose planning; or therapy. From this point of view, radiohalogens are an attractive group of radiolabels. Halogens have nuclides with a variety of physical properties while the chemical and biological properties of halogens are very similar. The same labelling procedures can be used for all heavy halogens, i.e. bromine, iodine and astatine. It has been demonstrated that the biodistribution of proteins labelled with different heavy halogens is quite similar. The main goal of the study was to develop protein radiohalogenation methods that provide a stable halogen-protein bond, convenient labelling chemistry that

Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera.

Science.gov (United States)

Miller, Brian W; Frost, Sofia H L; Frayo, Shani L; Kenoyer, Aimee L; Santos, Erlinda; Jones, Jon C; Green, Damian J; Hamlin, Donald K; Wilbur, D Scott; Fisher, Darrell R; Orozco, Johnnie J; Press, Oliver W; Pagel, John M; Sandmaier, Brenda M

2015-07-01

Alpha-emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over a few cell diameters (50-80 μm), causing localized, irreparable double-strand DNA breaks that lead to cell death. Radioimmunotherapy (RIT) approaches using monoclonal antibodies labeled with α emitters may thus inactivate targeted cells with minimal radiation damage to surrounding tissues. Tools are needed to visualize and quantify the radioactivity distribution and absorbed doses to targeted and nontargeted cells for accurate dosimetry of all treatment regimens utilizing α particles, including RIT and others (e.g., Ra-223), especially for organs and tumors with heterogeneous radionuclide distributions. The aim of this study was to evaluate and characterize a novel single-particle digital autoradiography imager, the ionizing-radiation quantum imaging detector (iQID) camera, for use in α-RIT experiments. The iQID camera is a scintillator-based radiation detection system that images and identifies charged-particle and gamma-ray/x-ray emissions spatially and temporally on an event-by-event basis. It employs CCD-CMOS cameras and high-performance computing hardware for real-time imaging and activity quantification of tissue sections, approaching cellular resolutions. In this work, the authors evaluated its characteristics for α-particle imaging, including measurements of intrinsic detector spatial resolutions and background count rates at various detector configurations and quantification of activity distributions. The technique was assessed for quantitative imaging of astatine-211 ((211)At) activity distributions in cryosections of murine and canine tissue samples. The highest spatial resolution was measured at ∼20 μm full width at half maximum and the α-particle background was measured at a rate as low as (2.6 ± 0.5) × 10(-4) cpm/cm(2) (40 mm diameter detector area). Simultaneous imaging of multiple tissue sections was

Abnormal radioactive decays out of long-lived super- and hyper-deformed isomeric states

International Nuclear Information System (INIS)

Marinov, A.; Gelberg, S.; Kolb, D.

2000-01-01

Complete text of publication follows. Recently (1-3) long-lived isomeric states have been found in the super- and hyper-deformed wells of the potential. These isomers manifested themselves by abnormal particle decays. An isomeric state in the superdeformed well of the potential in the parent nucleus can decay by very enhanced α-particle groups to superdeformed states in the daughter (1) or by very retarded α-particles (3) and also by protons (2) to normal states in the daughters. Similarly an isomeric state in the hyper-deformed well may decay by very retarded α-particle groups to superdeformed states (3), or by very enhanced α-groups to hyper-deformed states in the daughter nucleus (4). All these very unusual decay modes have been observed experimentally (1-4). For instance, a very high energy α-group of 8.6 MeV with 40d ≤ t 1/2 ≤ 2y (retardation factor of ∼10 13 ) has been observed in 195 Hg and interpreted as a III min → II min α-transition (3). Likewise, relatively low-energy and very enhanced α-particle groups (enhancement factors of 10 5 to 10 7 ) have been seen in several actinide sources and interpreted as due to II min → II min and III min → III min transitions (4). These unusual decay modes introduce new considerations in the study of heavy and superheavy elements. For instance, if low-energy α-particle groups around 4.4 - 4.6 MeV have been seen in nature (5), they may be interpreted as due to very enhanced III min → III min transitions in the superheavy element region around Z = 108 (eka-Os) with t 1/2 ∼10 8 y rather than ∼10 15 y as expected for normal α-transitions of such energies in this region, or due to very retarded III min → II min or II min → I min decays in nuclei around Os itself. In both cases, if such activities have been seen in nature, they indicate that the existence of the II min and III min isomeric states may be important in the nucleosynthesis process. It should be mentioned that long-lived high

On the use of {sup 76}Br-labelled monoclonal antibodies for PET : Preclinical evaluation of halogenated antibodies for diagnosis and treatment of cancer

Energy Technology Data Exchange (ETDEWEB)

Hoeglund, Johanna

2002-07-01

labelling resulted in high yields and mAbs with preserved immunoreactivity. In vivo characterization of {sup 76}Br-brominated mAb A33 showed that the indirect labelling method makes {sup 76}Br-brominated mAb A33 a promising candidate for tumour imaging with PET due to the faster excretion of radiolabelled catabolites compared with direct bromination. Finally, mAb A33 labelled with {sup 76}Br and 124/125I can be used to predict the {sup 211}At dose of astatinated mAb A33 in most organs given that a correction factor is applied for organs with varying uptake.

Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera

Energy Technology Data Exchange (ETDEWEB)

Miller, Brian W., E-mail: brian.miller@pnnl.gov [Pacific Northwest National Laboratory, Richland, Washington 99354 and College of Optical Sciences, The University of Arizona, Tucson, Arizona 85719 (United States); Frost, Sofia H. L.; Frayo, Shani L.; Kenoyer, Aimee L.; Santos, Erlinda; Jones, Jon C.; Orozco, Johnnie J. [Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 (United States); Green, Damian J.; Press, Oliver W.; Pagel, John M.; Sandmaier, Brenda M. [Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 and Department of Medicine, University of Washington, Seattle, Washington 98195 (United States); Hamlin, Donald K.; Wilbur, D. Scott [Department of Radiation Oncology, University of Washington, Seattle, Washington 98195 (United States); Fisher, Darrell R. [Dade Moeller Health Group, Richland, Washington 99354 (United States)

2015-07-15

Purpose: Alpha-emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over a few cell diameters (50–80 μm), causing localized, irreparable double-strand DNA breaks that lead to cell death. Radioimmunotherapy (RIT) approaches using monoclonal antibodies labeled with α emitters may thus inactivate targeted cells with minimal radiation damage to surrounding tissues. Tools are needed to visualize and quantify the radioactivity distribution and absorbed doses to targeted and nontargeted cells for accurate dosimetry of all treatment regimens utilizing α particles, including RIT and others (e.g., Ra-223), especially for organs and tumors with heterogeneous radionuclide distributions. The aim of this study was to evaluate and characterize a novel single-particle digital autoradiography imager, the ionizing-radiation quantum imaging detector (iQID) camera, for use in α-RIT experiments. Methods: The iQID camera is a scintillator-based radiation detection system that images and identifies charged-particle and gamma-ray/x-ray emissions spatially and temporally on an event-by-event basis. It employs CCD-CMOS cameras and high-performance computing hardware for real-time imaging and activity quantification of tissue sections, approaching cellular resolutions. In this work, the authors evaluated its characteristics for α-particle imaging, including measurements of intrinsic detector spatial resolutions and background count rates at various detector configurations and quantification of activity distributions. The technique was assessed for quantitative imaging of astatine-211 ({sup 211}At) activity distributions in cryosections of murine and canine tissue samples. Results: The highest spatial resolution was measured at ∼20 μm full width at half maximum and the α-particle background was measured at a rate as low as (2.6 ± 0.5) × 10{sup −4} cpm/cm{sup 2} (40 mm diameter detector area

Human biomonitoring of chromium and nickel from an experimental exposure to manual metal arc welding fumes of low and high alloyed steel.

Science.gov (United States)

Bertram, Jens; Brand, Peter; Schettgen, Thomas; Lenz, Klaus; Purrio, Ellwyn; Reisgen, Uwe; Kraus, Thomas

2015-05-01

The uptake and elimination of metals from welding fumes is currently not fully understood. In the Aachen Workplace Simulation Laboratory (AWSL) it is possible to investigate the impact of welding fumes on human subjects under controlled exposure conditions. In this study, the uptake and elimination of chromium or chromium (VI) respectively as well as nickel was studied in subjects after exposure to the emissions of a manual metal arc welding process using low or high alloyed steel. In this present study 12 healthy male non-smokers, who never worked as welders before, were exposed for 6h to welding fumes of a manual metal arc welding process. In a three-fold crossover study design, subjects were exposed in randomized order to either clean air, emissions from welding low alloyed steel, and emissions from welding high alloyed steel. Particle mass concentration of the exposure aerosol was 2.5mg m(-3). The content of chromium and nickel in the air was determined by analysing air filter samples on a high emission scenario. Urine analysis for chromium and nickel was performed before and after exposure using methods of human biomonitoring. There were significantly elevated chromium levels after exposure to welding fumes from high alloyed steel compared to urinary chromium levels before exposure to high alloyed welding fumes, as well as compared to the other exposure scenarios. The mean values increased from 0.27 µg l(-1) to 18.62 µg l(-1). The results were in good agreement with already existing correlations between external and internal exposure (German exposure equivalent for carcinogenic working materials EKA). The variability of urinary chromium levels was high. For urinary nickel no significant changes could be detected at all. Six-hour exposure to 2.5mg m(-3) high alloyed manual metal arc welding fumes lead to elevated urinary chromium levels far higher (7.11-34.16 µg l(-1)) than the German biological exposure reference value (BAR) of 0.6 µg l(-1) directly after

Silica colloids and their effect on radionuclide sorption. A literature review

International Nuclear Information System (INIS)

Hoelttae, P.; Hakanen, M.

2008-05-01

Silica sol, commercial colloidal silica manufactured by Eka Chemicals in Bohus, Sweden is a promising inorganic grout material for sealing small fractures in low permeable rock. This literature review collects information about the use of silica sol as an injection grout material, the properties of inorganic, especially silica colloids, colloid contents in granitic groundwater conditions, essential characterization methods and colloid-mediated transport of radionuclides. Objective was to evaluate the release and mobility of silica sol colloids, the effect of the groundwater conditions, the amount of colloids compared with natural colloids in Olkiluoto conditions, radionuclide sorption on colloids and their contribution to radionuclide transport. Silica sol seems to be a feasible material to seal fractures with an aperture as small as 10 μm in low permeable rock. The silica sol gel is sufficiently stable to limit to water ingress during the operational phase, the requirement that the pH should be below 11 is fulfilled and the compatibility with Engineered Barrier System (EBS) materials is expected to be good. No significant influence on the bentonite properties caused by the silica sol is expected when calcium chloride is used as an accelerator but the influence of sodium chloride has not been examined. No significant release of colloids is expected under prevailing groundwater conditions. The long-term (100 y) stability of silica sol gel has not yet been clearly demonstrated and a long-term release of silica colloids cannot be excluded. The question is the amount of colloids, how mobile they are and the influence of possible glacial melt waters. The bentonite buffer used in the EBS system is assumed to be a potential source of colloids. In a study in Olkiluoto, bentonite colloids were found only in low salinity groundwater. In general, low salinity water (total dissolved solids -1 ) favours colloid stability and bentonite colloids can remain stable over long

Bali, Shaded Relief and Colored Height

Science.gov (United States)

2004-01-01

The volcanic nature of the island of Bali is evident in this shaded relief image generated with data from the Shuttle Radar Topography Mission (SRTM).Bali, along with several smaller islands, make up one of the 27 Provinces of Indonesia. It lies over a major subduction zone where the Indo-Australian tectonic plate collides with the Sunda plate, creating one of the most volcanically active regions on the planet.The most significant feature on Bali is Gunung Agung, the symmetric, conical mountain at the right-center of the image. This 'stratovolcano,' 3,148 meters (10,308 feet) high, is held sacred in Balinese culture, and last erupted in 1963 after being dormant and thought inactive for 120 years. This violent event resulted in over 1,000 deaths, and coincided with a purification ceremony called Eka Dasa Rudra, meant to restore the balance between nature and man. This most important Balinese rite is held only once per century, and the almost exact correspondence between the beginning of the ceremony and the eruption is though to have great religious significance.Two visualization methods were combined to produce the image: shading and color coding of topographic height. The shade image was derived by computing topographic slope in the northwest-southeast direction, so that northwest slopes appear bright and southeast slopes appear dark. Color coding is directly related to topographic height, with green at the lower elevations, rising through yellow and tan, to white at the highest elevations.Elevation data used in this image were acquired by the Shuttle Radar Topography Mission aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot

The Applicability of Incoherent Array Processing to IMS Seismic Array Stations

Science.gov (United States)

Gibbons, S. J.

2012-04-01

The seismic arrays of the International Monitoring System for the CTBT differ greatly in size and geometry, with apertures ranging from below 1 km to over 60 km. Large and medium aperture arrays with large inter-site spacings complicate the detection and estimation of high frequency phases since signals are often incoherent between sensors. Many such phases, typically from events at regional distances, remain undetected since pipeline algorithms often consider only frequencies low enough to allow coherent array processing. High frequency phases that are detected are frequently attributed qualitatively incorrect backazimuth and slowness estimates and are consequently not associated with the correct event hypotheses. This can lead to missed events both due to a lack of contributing phase detections and by corruption of event hypotheses by spurious detections. Continuous spectral estimation can be used for phase detection and parameter estimation on the largest aperture arrays, with phase arrivals identified as local maxima on beams of transformed spectrograms. The estimation procedure in effect measures group velocity rather than phase velocity and the ability to estimate backazimuth and slowness requires that the spatial extent of the array is large enough to resolve time-delays between envelopes with a period of approximately 4 or 5 seconds. The NOA, AKASG, YKA, WRA, and KURK arrays have apertures in excess of 20 km and spectrogram beamforming on these stations provides high quality slowness estimates for regional phases without additional post-processing. Seven arrays with aperture between 10 and 20 km (MJAR, ESDC, ILAR, KSRS, CMAR, ASAR, and EKA) can provide robust parameter estimates subject to a smoothing of the resulting slowness grids, most effectively achieved by convolving the measured slowness grids with the array response function for a 4 or 5 second period signal. The MJAR array in Japan recorded high SNR Pn signals for both the 2006 and 2009 North Korea

Alpha particle emitters in cancer therapy: establishing the rationale and overcoming the difficulties

International Nuclear Information System (INIS)

Sgouros, G.

1996-01-01

Full text: Once a tumor has metastasized, the possibility of cure is significantly diminished, if not excluded. Since metastatic spread arises due to the release of single tumor cells or tumor cell clusters, treatment regimens following an overt metastasis must include agents that eradicate individual tumor cells and cell clusters or that prevent their dissemination. Alpha particles may be highly effective in eradicating rapidly accessible disease. The effectiveness of alpha particles arises because the amount of energy deposited per unit distance traveled (linear energy transfer or LET) is approximately 400 times greater than that of beta particles (80 keV/μm vs. 0.2 keV/μm). Each traversal of an alpha particle through a cell nucleus results in a very highly ionizing track. Cell survival studies have shown that alpha-particle killing is independent of oxygenation state or cell-cycle during irradiation and that as few as 1 to 6 tracks across the nucleus may result in cell death. Most studies with alpha-particle emitting radionuclides for therapy have examined either bismuth-212 or astatine-211. Both radionuclides are short-lived with 61 minute and 7.2 hour half-lives, respectively, yielding intermediates with 3-minute and 32 year half-lives, respectively. Both emit alpha particles whose range is 40 to 80 μm. Alpha-particle emitting radionuclides have been attached to antibodies against tumor cell associated antigen. Antibodies have been the most widely used vehicle for delivery of alpha particles due to their specificity. Bismuth-212 has demonstrated a significant curative potential with minimal toxicity. In an ascites tumor mouse model, specific targeting and 80% cure following injection of Bi-212-labeled antibody has been observed (Macklis RM et al, Science, 240:1024-1026, 1988). It is important to define the realm of applicability for alpha particle emitting radionuclides. The short half-life of most currently available radionuclides, limits their use to

FAKTOR RISIKO KEGEMUKAN PADA WANITA DEWASA INDONESIA

Directory of Open Access Journals (Sweden)

Rian Diana

2013-11-01

.875, pendapatan rumah tangga (OR untuk pendapatan menengah ke atas=1.566; 95%CI:1.504—1.631, tipe wilayah (OR untuk perkotaan=1.358; 95%CI:1.304—1.413, aktivitas fisik (OR untuk aktivitas ringan=1.213; 95%CI:1.153—1.275, energi dari karbohidrat (EKA (OR untuk EKA≥55%=1.119; 95%CI:1.067—1.173, serta energi dari makanan dan minuman manis (EMM (OR untuk EMM≥10%=1.100; 95%CI:1.037—1.166. Tingkat pendidikan (OR untuk pendidikan lebih tinggi=0.817; 95%CI:0.782—0.853 merupakan faktor protektif kegemukan. Penelitian ini berimplikasi pada pentingnya mempromosikan aktivitas fisik dan diet yang sehat terutama menurunkan konsumsi makanan dan minuman manis dan konsumsi karbohidrat yang tidak berlebih untuk pencegahan dan pengendalian kegemukan.Kata kunci: faktor risiko, kegemukan, makanan manis, perempuan

Therapy with high LET Radioisotopes: Can sufficient levels of attractive Auger and alpha emitters be produced to make their use practical?

International Nuclear Information System (INIS)

Knapp, F.F. Jr.; Mirzadeh, S.; Stabin, M.; Brill, A.B.

2005-01-01

Because of localized energy deposition within a very small volume, cellular targeted therapy with high linear energy transfer (LET) Auger-electron and alpha-particle emitting radioisotopes is of great interest. While the energy deposition from alpha particles usually encompasses several cell diameters, the dose from Auger electrons is confined to a single cell. Two major challenges for broader use of Alpha and Auger emitters are the efficient and cost effective routine production of sufficient levels of these radioisotopes, and the availability of targeting molecules to which the radioisotopes can be attached for cellular delivery of sufficient levels of activity for effective therapy. Examples of several Alpha-and Auger-emitting radioisotopes of current interest are presented. Alpha- and Auger electron-emitting radioisotopes can be produced in accelerators (A) and nuclear reactors (R), and several alpha emitter congeners (i.e. thorium-229) can be obtained from uranium decay products. The challenge for reactor production, is the availability and exploitation of methods - other then the usual radiative (n,γ) production route which will provide no-carrier-added (nca) or the high specific activity radioisotopes of interest. The submitted manuscript has been authored by a contractor of the U.S. Government under contract DE-AC05-00OR22725. Accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes High LET radioisotopes of current interest which are in the initial stages of development and/or which demonstrate practical use in clinical trials include several alpha-emitters, in particular bismuth-213 - and also the actinium-225 parent - astatine-211 and bismuth-212. Extensive experimental studies have been reported with Auger iododeoxyuridine (IdUR) radiolabeled with the iodine-125 emitter-labeled. However, development of production

Liet. eikvóti: reikšmė, daryba, etimologija

Directory of Open Access Journals (Sweden)

Simas Karaliūnas

2011-10-01

��naughty, mischievous, spoilt, wan­ton”, seems to belong to this group of cognate words, too. Toch. A ekär, B aikare „empty“, Toch A ekro „misarable, poor, scanty” could be seen as cognates of Lith. *áiklas „naughty, mischievous, spoit, wanton”, * aiklas/*eiklas „mischievous, restless person, fidget, rake” with regard to their formatives -r-; -l- and semantic affiliation (semasiologically cf. Lith. dỹkas „empty, hollow; naughty, mischievous, spoit”. In view of these facts a separate root *aik-/*eik- „stir, move, become restless, fidgety; cast, fling, hurl” could be reconstructed for Protobaltic. Latv. iecava „space behind an oven, space between an oven and wall; stove-pipe” and possibly „Narev Baltic" ajki „time”,if it is from *aikai „fine, hot weather”, would suggest another Protobaltic root *aik-/*eik- „burn, become heated, incandesce”.

Gothenburg Experience with At-211-MX35 for Targeting Ovarian Carcinomas

International Nuclear Information System (INIS)

Elgqvist, J.

2009-01-01

This review will cover the efforts in Gothenburg to evaluate the potential of 211 At radioimmunotherapy (RIT) in the treatment of small tumor deposits of ovarian cancer in the abdominal cavity. The lifetime risk of ovarian cancer is 1% - 2% in European and American women. Despite seemingly successful surgery followed by chemotherapy, most patients will relapse, most frequently in the abdominal cavity, and succumb to the disease. Despite newer systemic chemotherapy regimens, the outcome has not improved over the past decade. RIT with various β-emitters has displayed promising results, though an international Phase III study of 90Y-labeled antibody showed no improvement in time to relapse or survival. This disappointing result might be explained by the long range of β-emitters, which results in poor irradiation of tumors less than a few millimeters in size. In treating small tumors, the short range and high LET of α-emitters such as 211 At offer a significant advantage by more effectively irradiating targeted small cell clusters. The PET and Cyclotron Unit at Rigshospitalet in Copenhagen has regularly since ∼10 years delivered 211 At to the research group in Gothenburg led by Prof. Ragnar Hultborn and Prof. Lars Jacobsson. Astatine-211 is isolated from the irradiated target by dry distillation. The 211 At-labelling method gives stable radiochemical yields of 70% - 80% with the antibody conjugate's tumor-cell binding ability essentially preserved. The activity of an antibody batch of 0.1 - 0.5 mg is approximately 300 - 500 MBq, sufficient for extensive animal experiments or for treatment of one patient. The therapeutic effect has been studied in a series of experiments in vitro and in nude mice with intraperitoneal (i.p.) growth of microscopic ovarian cancer tumors. A number of parameters related to the injected antibody conjugate and stage of tumor growth have been investigated. Studies of toxic effects for bone-marrow, kidneys, and the peritoneal membrane

Production, Isolation and Radiolabeling Methods for 211AT- Labeling of Biomolecules

International Nuclear Information System (INIS)

Wilbur, D.S.; Hamlin, D.K.; Chyan, M.

2009-01-01

Targeted alpha therapy with 211 At-labeled compounds holds great promise for treatment of cancer, particularly compartmentalized cancer (e.g. ovarian cancer), minimal residual cancer after surgery and metastatic disease. Unfortunately, 211 At has limited availability and, due to its unique nature, has the potential to be readily dissociated from the cancer-targeting agents used in vivo. Finding methods to circumvent these two problems has occupied a large amount of our efforts over the past few years. 211 At is produced at the University of Washington on a Scanditronix MC-50 using a 28 MeV alpha beam. Our initial preclinical studies were conducted using a small target assembly with irradiations of a 10 □ A alpha beam, but our desire to ultimately conduct clinical studies led to the design and installation of a new target assembly that had much larger irradiation surface and would withstand beam energies of 50 □A or more. Prior to this upgrade, 211 At was efficiently isolated (60-80%) from the irradiated aluminum-backed bismuth targets by dry distillation at 650 o C. However, the dry distillation method gave low recovery yields (e.g. 10-40%) when the much larger new targets were used. After some attempts to improve the distillation yields, we have more recently conducted a wet chemistry approach to the 211 At isolation. While this method still needs to be optimized, it has provided good recovery (60-90%) of the 211 At. Our radiolabeling methods have undergone a similar transition in the past few years. Until recently our 211 At studies were limited to the use of intact monoclonal antibodies (MAb) labeled using conjugates containing aryl-astatine derivatives due to the deastatination of more rapidly metabolized targeting biomolecules. This limitation made it all but impossible to label important biomolecules such as MAb fragments, engineered proteins, peptides and small molecules. This critical shortcoming of labeling methods for 211 At led to our investigating