WorldWideScience

Sample records for dystrophin-deficient cavalier king

  1. A duchenne muscular dystrophy gene hot spot mutation in dystrophin-deficient cavalier king charles spaniels is amenable to exon 51 skipping.

    Directory of Open Access Journals (Sweden)

    Gemma L Walmsley

    Full Text Available BACKGROUND: Duchenne muscular dystrophy (DMD, which afflicts 1 in 3500 boys, is one of the most common genetic disorders of children. This fatal degenerative condition is caused by an absence or deficiency of dystrophin in striated muscle. Most affected patients have inherited or spontaneous deletions in the dystrophin gene that disrupt the reading frame resulting in unstable truncated products. For these patients, restoration of the reading frame via antisense oligonucleotide-mediated exon skipping is a promising therapeutic approach. The major DMD deletion "hot spot" is found between exons 45 and 53, and skipping exon 51 in particular is predicted to ameliorate the dystrophic phenotype in the greatest number of patients. Currently the mdx mouse is the most widely used animal model of DMD, although its mild phenotype limits its suitability in clinical trials. The Golden Retriever muscular dystrophy (GRMD model has a severe phenotype, but due to its large size, is expensive to use. Both these models have mutations in regions of the dystrophin gene distant from the commonly mutated DMD "hot spot". METHODOLOGY/PRINCIPAL FINDINGS: Here we describe the severe phenotype, histopathological findings, and molecular analysis of Cavalier King Charles Spaniels with dystrophin-deficient muscular dystrophy (CKCS-MD. The dogs harbour a missense mutation in the 5' donor splice site of exon 50 that results in deletion of exon 50 in mRNA transcripts and a predicted premature truncation of the translated protein. Antisense oligonucleotide-mediated skipping of exon 51 in cultured myoblasts from an affected dog restored the reading frame and protein expression. CONCLUSIONS/SIGNIFICANCE: Given the small size of the breed, the amiable temperament and the nature of the mutation, we propose that CKCS-MD is a valuable new model for clinical trials of antisense oligonucleotide-induced exon skipping and other therapeutic approaches for DMD.

  2. Xanthinuria in a family of Cavalier King Charles spaniels

    NARCIS (Netherlands)

    vanZuilen, CD; Nickel, RF; vanDijk, TH; Reijngoud, DJ

    1997-01-01

    Xanthine calculi mere found in a 7-month-old male Cavalier King Charles spaniel with urethral obstruction and renal insufficiency, Because the only two other reported cases of naturally occurring xanthine urolithiasis concerned a Cavalier King Charles and a King Charles spaniel the urine of the litt

  3. Eosinophilic diseases in two Cavalier King Charles spaniels.

    Science.gov (United States)

    German, A J; Holden, D J; Hall, E J; Day, M J

    2002-12-01

    This report describes the clinical presentation of two Cavalier King Charles spaniels with different eosinophilic diseases. The first case presented with dyspnoea and a non-productive cough, and investigations demonstrated eosinophilic bronchopneumonopathy. The second dog was referred for the investigation of haemorrhagic vomiting and diarrhoea and was eventually diagnosed with eosinophilic enteritis. Both dogs had concurrent eosinophilic stomatitis, and both responded completely to immunosuppressive glucocorticoid therapy. This report is the first to describe the concurrence of eosinophilic stomatitis and systemic eosinophilic disease in Cavalier King Charles spaniels, and suggest that this breed may be predisposed to eosinophilic syndromes.

  4. Chiari-like malformation and syringomyelia in cavalier King Charles spaniels

    NARCIS (Netherlands)

    Rusbridge, C.

    2007-01-01

    This thesis is the cumulation of over a decade of study into the pathogenesis and treatment Chiari-like malformation and syringomyelia (CM/SM) in the cavalier King Charles spaniel (CKCS). Chiari-like malformation is a condition where the brain is too big for the skull and is crushed and pushed out t

  5. Heart Rate Variability in Cavalier King Charles Spaniels with Different Degree of Myxomatous Mitral Valve Disease

    DEFF Research Database (Denmark)

    Rasmussen, Caroline Elisabeth; Falk, Bo Torkel; Zois, Nora Elisabeth;

    2010-01-01

    variability (HRV). Reduced HRV is seen in dogs with heart failure secondary to myxomatous mitral valve disease (MMVD). However, HRV is suggested to increase with disease progression in dogs with early stages of MMVD. Comparable results are found in people with primary mitral valve prolapse, a disease......Heart Rate Variability in Cavalier King Charles Spaniels with Different Degree of Myxomatous Mitral Valve Disease Rasmussen, C.E. 1, Falk, T. 1, Zois, N.E. 1, Moesgaard, S.G. 1, Häggström, J. 2, Pedersen, H.D. 3 and Olsen, L.H1. 1Department of Basic Animal and Veterinary Sciences, Faculty of Life......age. Discussion and conclusion: Most HRV variables decreased with progression of MMVD in dogs; even prior to the development of overt congestive heart failure....

  6. Prevalence of pancreatic, hepatic and renal microscopic lesions in post-mortem samples from Cavalier King Charles Spaniels

    OpenAIRE

    Kent, Andrew C. C.; Constantino-Casas, Fernando; Rusbridge, Clare; Corcoran, Brendan; Carter, Margaret; Ledger, Tania; Watson, Penny J.

    2016-01-01

    This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Wiley. Objectives: To describe the prevalence of pancreatic, hepatic and renal microscopic lesions in post-mortem samples from Cavalier King Charles Spaniels (CKCS) presented to a UK post-mortem collection scheme. Methods: Histopathology was performed on the organs of interest and the prevalence of microscopic lesions described, this was related back to the clinical signs shown an...

  7. Longitudinal Study of the Relationship among Craniocervical Morphology, Clinical Progression, and Syringomyelia in a Cohort of Cavalier King Charles Spaniels

    OpenAIRE

    Cerda‐Gonzalez, S.; Olby, N.J.; Griffith, E.H.

    2016-01-01

    Background Craniocervical junction (CCJ) anomalies and secondary syringomyelia are commonly diagnosed in Cavalier King Charles spaniel (CKCS). Familiarity with the natural history of these abnormalities is vital to understanding the disease syndrome. Objective To evaluate magnetic resonance imaging (MRI) predictors of worsening clinical signs, syringomyelia, and morphology in CKCS longitudinally. Animals Fifty‐four client‐owned CKCS, 5–13 years old; 50% currently symptomatic. Methods Longitud...

  8. Platelet function and activation in Cavalier King Charles Spaniels with subclinical chronic valvular heart disease.

    Science.gov (United States)

    Tong, Linda J; Hosgood, Giselle L; French, Anne T; Irwin, Peter J; Shiel, Robert E

    2016-08-01

    OBJECTIVE To assess platelet closure time (CT), mean platelet component (MPC) concentration, and platelet component distribution width (PCDW) in dogs with subclinical chronic valvular heart disease. ANIMALS 89 Cavalier King Charles Spaniels (CKCSs) and 39 control dogs (not CKCSs). PROCEDURES Platelet count, MPC concentration, PCDW, and Hct were measured by use of a hematology analyzer, and CT was measured by use of a platelet function analyzer. Murmur grade and echocardiographic variables (mitral valve regurgitant jet size relative to left atrial area, left atrial-to-aortic diameter ratio, and left ventricular internal dimensions) were recorded. Associations between explanatory variables (sex, age, murmur grade, echocardiographic variables, platelet count, and Hct) and outcomes (CT, MPC concentration, and PCDW) were examined by use of multivariate regression models. RESULTS A model with 5 variables best explained variation in CT (R(2), 0.74), with > 60% of the variance of CT explained by mitral valve regurgitant jet size. The model of best fit to explain variation in MPC concentration included only platelet count (R(2), 0.24). The model of best fit to explain variation in PCDW included platelet count and sex (R(2), 0.25). CONCLUSIONS AND CLINICAL RELEVANCE In this study, a significant effect of mitral valve regurgitant jet size on CT was consistent with platelet dysfunction. However, platelet activation, as assessed on the basis of the MPC concentration and PCDW, was not a feature of subclinical chronic valvular heart disease in CKCSs.

  9. Holter monitoring in clinically healthy Cavalier King Charles Spaniels, Wire-haired Dachshunds, and Cairn Terriers.

    Science.gov (United States)

    Rasmussen, C E; Vesterholm, S; Ludvigsen, T P; Häggström, J; Pedersen, H D; Moesgaard, S G; Olsen, L H

    2011-01-01

    Few reported studies describe normal values from 24-hour ECG (Holter) recordings of small breed dogs. To investigate influence of breed, age, sex, body weight, degree of recording artifact, and mitral valve prolapse (MVP) on Holter recordings of 3 breeds of small dogs that have differing predispositions for myxomatous mitral valve disease. The study also assessed if heart rate (HR) at clinical examination (HRex) was associated with HR during Holter monitoring and evaluated the reproducibility of Holter variables. Fifty clinically healthy, privately owned dogs of the breeds Cavalier King Charles Spaniel (CKCS), Wire-haired Dachshund (wD), or Cairn Terrier (CT). Prospective, longitudinal observational study. Dogs were recruited for clinical examination, echocardiography, and Holter monitoring. In 8 CKCS, Holter recordings were performed twice with a 7-day interval. Arrhythmia and heart rate variability (HRV) analysis (time and frequency domain analysis) were performed on Holter recordings. Fifteen out of 27 Holter derived variables were significantly associated with breed (P .7), sex (P > .2), body weight (P > .7), degree of recording artifact (P > .4), or MVP (P > .6). During Holter recording, minimum (P = .0001) and mean HR (P = .0001) were higher in CKCS compared with wD. CKCS had significantly lower values than wD, CT, or both in 10 out of 13 HRV variables (P Holter recording were correlated with HRex (r = 0.55, P = .0003). HR and time domain variables had a coefficient of variation Holter-derived variables in 3 breeds of small dogs. Arrhythmia and HRV analysis can be performed on 24-hour ambulatory ECG (Holter) recordings. Arrhythmia analysis includes HR measurements and identification of arrhythmias. Copyright © 2011 by the American College of Veterinary Internal Medicine.

  10. Volume reduction of the jugular foramina in Cavalier King Charles Spaniels with syringomyelia

    Directory of Open Access Journals (Sweden)

    Schmidt Martin

    2012-09-01

    Full Text Available Abstract Background Understanding the pathogenesis of the chiari-like malformation in the Cavalier King Charles Spaniel (CKCS is incomplete, and current hypotheses do not fully explain the development of syringomyelia (SM in the spinal cords of affected dogs. This study investigates an unconventional pathogenetic theory for the development of cerebrospinal fluid (CSF pressure waves in the subarachnoid space in CKCS with SM, by analogy with human diseases. In children with achondroplasia the shortening of the skull base can lead to a narrowing of the jugular foramina (JF between the cranial base synchondroses. This in turn has been reported to cause a congestion of the major venous outflow tracts of the skull and consequently to an increase in the intracranial pressure (ICP. Amongst brachycephalic dog breeds the CKCS has been identified as having an extremely short and wide braincase. A stenosis of the JF and a consequential vascular compromise in this opening could contribute to venous hypertension, raising ICP and causing CSF jets in the spinal subarachnoid space of the CKCS. In this study, JF volumes in CKCSs with and without SM were compared to assess a possible role of this pathologic mechanism in the development of SM in this breed. Results Computed tomography (CT scans of 40 CKCSs > 4 years of age were used to create three-dimensional (3D models of the skull and the JF. Weight matched groups (7–10 kg of 20 CKCSs with SM and 20 CKCSs without SM were compared. CKCSs without SM presented significantly larger JF -volumes (median left JF: 0.0633 cm3; median right JF: 0.0703 cm3; p 3; median right JF: 0.0434 cm3; p Conclusion A stenosis of the JF and consecutive venous congestion may explain the aetiology of CSF pressure waves in the subarachnoid space, independent of cerebellar herniation, as an additional pathogenetic factor for the development of SM in this breed.

  11. 24-HOUR ELECTROCARDIOGRAPHY IN CLINICAL HEALTHY CAVALIER KING CHARLES SPANIELS, WIRE-HAIRED DACHSHUNDS AND CAIRN TERRIERS

    DEFF Research Database (Denmark)

    Rasmussen, Caroline Elisabeth; Vesterholm, Stina; Ludvigsen, Trine Pagh

    2010-01-01

    24-HOUR ELECTROCARDIOGRAPHY IN CLINICAL HEALTHY CAVALIER KING CHARLES SPANIELS, WIRE-HAIRED DACHSHUNDS AND CAIRN TERRIERS. CE Rasmussen1, S Vesterholm1, TP Ludvigsen1, SG Moesgaard1, HD Pedersen2, J Häggström3, LH Olsen1. 1. Department of Basic Animal and Veterinary Sciences, Faculty of Life...... two and nine years old and clinical healthy based on history, clinical examination, echocardiography, serum biochemistry and complete blood count. All dogs were Holter recorded for 24 hours using a CF-life recorder with electrodes placed in a two-lead precordial position. A blinded semiautomatic...

  12. Breeding Restrictions Decrease the Prevalence of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels over an 8-to 10-Year Period

    DEFF Research Database (Denmark)

    Birkegård, Anna Camilla; Reimann, M. J.; Martinussen, T.

    2016-01-01

    Background: Cavalier King Charles Spaniels (CKCS) are predisposed to myxomatous mitral valve disease (MMVD). Studies have indicated a strong genetic background. Objective: The aim of this study was to evaluate the effect of a breeding scheme involving auscultation and echocardiography. Animals...

  13. Changes in serum progesterone concentrations in Bernese mountain dogs and Cavalier King Charles Spaniels during pregnancy.

    Science.gov (United States)

    Thejll Kirchhoff, K; Goericke-Pesch, S

    2016-10-15

    Progesterone (P4) concentrations during canine pregnancy follow a specific pattern. Although the general pattern is similar, it is likely that breed-specific differences exist. Detailed knowledge about the physiological range of P4 concentrations may be helpful in cases of suspected hypoluteoidism. The aim of this study was to investigate P4 changes during pregnancy in a small and a large breed, to obtain reference values for specific intervals during pregnancy and to test for breed- or body weight-specific differences. We studied P4 concentrations in pregnancies from healthy Bernese mountain dogs (BMDs, n = 6) and Cavalier King Charles Spaniels (CKCSs, n = 6) with a normal reproductive history. Blood samples for P4 were taken to determine the day of ovulation and after confirmation of pregnancy in regular intervals from Days 23 to 29 to Days 60 to 64. Bernese mountain dogs delivered 6.2 ± 2.6 puppies (range: 3-9) 63.4 ± 1.5 (range: 61-65) days after ovulation (excluding data from one BMD with elective c-section) and CKCS delivered 3.3 ± 1.9 puppies (range: 1-5) 63.5 ± 1.1 (range: 62-65) days after ovulation. In general, the P4 concentrations of individual dogs continuously decreased from the first to the last sampling during pregnancy. Respective mean concentrations were Days 23 to 29: 19.2 ± 4.3/22.2 ± 3.9 ng/mL (BMD/CKCS), Days 30 to 34: 15.6 ± 2.3/17.7 ± 5.8 ng/mL, Days 35 to 39: 12.5 ± 2.8/14.1 ± 3.4 ng/mL, Days 40 to 44: 8.9 ± 1.4/11.8 ± 3.7 ng/mL, Days 45 to 49: 7.7 ± 1.6/8.9 ± 1.9 ng/mL, Days 50 to 54: 6.0 ± 1.3/8.7 ± 7.1 ng/mL, Days 55 to 59: 4.7 ± 1.2/5.3 ± 2.8 ng/mL, and Days 60 to 64: 3.69 ± 1.86/2.62 ± 0.42 ng/mL. ANOVA indicated significant differences over time within each breed when considered individually (P < 0.0001 each), but not between breeds although mean P4 was slightly lower in BMD until Days 55 to 59. The present data clearly confirm the previously described P4 pattern

  14. Advanced electrocardiography can predict mitral regurgitation in cavalier king charles spaniels with myxomatous mitral valve disease

    DEFF Research Database (Denmark)

    Spiljak, Maja; Petric, Alexandra; Olsen, Lisbeth Høier

    2011-01-01

    . Clinic for Surgery and Small Animal Medicine, Veterinary Faculty, University of Ljubljana, Slovenia. 3. Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Denmark. 4. Quality Control Department, Metallurgical and Chemical Industry Cinkarna Celje, INC...... onset of symptoms or changes in the standard ECG. Therefore, this study investigates, if advanced ECG can predict the severity of mitral regurgitation (MR) in dogs with myxomatous mitral valve disease (MMVD) and thereby improve the diagnostic value of ECG. The study included 77 privately owned Cavalier...

  15. Changes over time in craniocerebral morphology and syringomyelia in cavalier King Charles spaniels with Chiari-like malformation

    Directory of Open Access Journals (Sweden)

    Driver Colin J

    2012-11-01

    Full Text Available Abstract Background Chiari-like malformation (CM and syringomyelia is a neurological disease complex with high prevalence in cavalier King Charles spaniels (CKCS. The natural progression of this disease with time has not been described. The objectives of this study were to i determine if syringomyelia progresses with time ii determine if features of craniocrebral morphology previously associated with CM are progressive (including caudal cranial fossa volume, caudal cranial fossa parenchymal volume, ventricular dimensions, height of the foramen magnum and degree of cerebellar herniation. A retrospective morphometric analysis was undertaken in 12 CKCS with CM for which repeat magnetic resonance images were available without surgical intervention. Results The maximal syrinx width, height of the foramen magnum, length of cerebellar herniation and caudal cranial fossa volume increased over time. Ventricular and caudal fossa parenchymal volumes were not significantly different between scans. Conclusions The results of this study suggest that syringomyelia progresses with time. Increased caudal cranial fossa volume may be associated with active resorption of the supraoccipital bone, which has previously been found in histology specimens from adult CKCS. We hypothesise that active resorption of the supraoccipital bone occurs due to pressure from the cerebellum. These findings have important implications for our understanding of the pathogenesis and variable natural clinical progression of CM and syringomyelia in CKCS.

  16. Advanced electrocardiography can predict mitral regurgitation in cavalier king charles spaniels with myxomatous mitral valve disease

    DEFF Research Database (Denmark)

    Spiljak, Maja; Petric, Alexandra; Olsen, Lisbeth Høier

    2011-01-01

    ., Slovenia Recently, multiple advanced resting electrocardiographic (ECG) techniques have been applied in humans for detection of cardiac autonomic and repolarisation function. This has improved the diagnostic and/or prognostic value of short-time ECG in detection of common human cardiac diseases even before...... King Charles Spaniels (CKCSs) (age 6.0 ± 2.7 years; 30 males and 47 females). All dogs were examined by echocardiography and a short-time (3-5 min) high-fidelity 12-lead ECG, with the dog in a resting position and in sinus rhythm. Dogs were divided into 5 groups according to the degree of MR estimated...... as the percentage of the left atrium area using color Doppler mapping (0%; 0% 50%; jet = 100% and with clinical signs of congestive heart failure). ECG recordings were evaluated via custom software programs to calculate 76 different parameters, including heart rate variability...

  17. Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates

    DEFF Research Database (Denmark)

    Thøfner, Maria Søndergaard; Stougaard, C. L.; Westrup, Ulrik;

    2015-01-01

    (P IMPORTANCE: The prevalence of symptomatic SM is high......BACKGROUND: Syringomyelia (SM) is common in the Cavalier King Charles Spaniel (CKCS). Dogs with syringes express clinical signs or might be clinically silent. OBJECTIVES: To investigate the prevalence and heritability of symptomatic SM, the association between clinical signs and magnetic resonance...... imaging (MRI) findings, and long-term outcome. ANIMALS: All CKCS registered in the Danish Kennel Club in 2001 (n = 240). METHODS: A cross-sectional questionnaire-based prevalence study validated by telephone interviews and clinically investigated clinical signs of SM. Dogs were 6 years at the time...

  18. Laryngeal Muscles Are Spared in the Dystrophin Deficient "mdx" Mouse

    Science.gov (United States)

    Thomas, Lisa B.; Joseph, Gayle L.; Adkins, Tracey D.; Andrade, Francisco H.; Stemple, Joseph C.

    2008-01-01

    Purpose: "Duchenne muscular dystrophy (DMD)" is caused by the loss of the cytoskeletal protein, dystrophin. The disease leads to severe and progressive skeletal muscle wasting. Interestingly, the disease spares some muscles. The purpose of the study was to determine the effects of dystrophin deficiency on 2 intrinsic laryngeal muscles, the…

  19. Disodium cromoglycate protects dystrophin-deficient muscle fibers from leakiness.

    Science.gov (United States)

    Marques, Maria Julia; Ventura Machado, Rafael; Minatel, Elaine; Santo Neto, Humberto

    2008-01-01

    In dystrophin-deficient fibers of mdx mice and in Duchenne dystrophy, the lack of dystrophin leads to sarcolemma breakdown and muscle degeneration. We verified that cromolyn, a mast-cell stabilizer agent, stabilized dystrophic muscle fibers using Evans blue dye as a marker of sarcolemma leakiness. Mdx mice (n=8; 14 days of age) received daily intraperitoneal injections of cromolyn (50 mg/kg body weight) for 15 days. Untreated mdx mice (n=8) were injected with saline. Cryostat cross-sections of the sternomastoid, tibialis anterior, and diaphragm muscles were stained with hematoxylin and eosin. Cromolyn dramatically reduced Evans blue dye-positive fibers in all muscles (P<0.05; Student's t-test) and led to a significant increase in the percentage of fibers with peripheral nuclei. This study supports the protective effects of cromolyn in dystrophic muscles and further indicates its action against muscle fiber leakiness in muscles that are differently affected by the lack of dystrophin.

  20. Long-term outcome of Cavalier King Charles spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia.

    Science.gov (United States)

    Plessas, I N; Rusbridge, C; Driver, C J; Chandler, K E; Craig, A; McGonnell, I M; Brodbelt, D C; Volk, H A

    2012-11-17

    The disease complex Chiari-like malformation (CM) and syringomyelia (SM) has been associated with the development of neuropathic pain (NeP), and commonly affects Cavalier King Charles spaniels (CKCS). This prospective cohort study followed 48 CKCSs with CM and/or SM and clinical signs suggestive of NeP for a period of 39 (±14.3) months from diagnosis. At the end of the study, 36 dogs were still alive; five dogs died of an unrelated or unknown cause, and seven were euthanased due to severe clinical signs suggestive of NeP. During the follow-up period, the clinical signs of scratching, facial rubbing behaviour, vocalisation and exercise ability were evaluated. Nine out of 48 dogs stopped scratching (Pchange in the number of dogs exhibiting exercise intolerance, vocalisation or facial rubbing behaviour. The overall severity of clinical signs based on a visual analogue scale (VAS) (0 mm: no clinical signs 100 mm: severe clinical signs) increased (from median 75 mm (interquartile ranges (IQR) 68-84) to 84 mm (IQR 71.5-91), Pgeneral, the majority of the owners felt that the quality of life of their dogs was acceptable. Medical treatments received were gabapentin or pregabalin and/or intermittently, carprofen. The owner's perception of their animal's progress, and progress based on VAS, had strong positive correlation (Spearman's rank correlation (s(r)) 0.74, P<0.001). Overall, this study suggests that clinical signs suggestive of NeP progress in three-quarters of CKCSs with CM and/or SM.

  1. Craniometric Analysis of the Hindbrain and Craniocervical Junction of Chihuahua, Affenpinscher and Cavalier King Charles Spaniel Dogs With and Without Syringomyelia Secondary to Chiari-Like Malformation

    Science.gov (United States)

    Kiviranta, Anna-Mariam; McFadyen, Angus K.; Jokinen, Tarja S.; La Ragione, Roberto M.; Rusbridge, Clare

    2017-01-01

    Objectives To characterize and compare the phenotypic variables of the hindbrain and craniocervical junction associated with syringomyelia (SM) in the Chihuahua, Affenpinscher and Cavalier King Charles Spaniel (CKCS). Method Analysis of 273 T1-weighted mid-sagittal DICOM sequences of the hindbrain and craniocervical junction from 99 Chihuahuas, 42 Affenpinschers and 132 CKCSs. The study compared 22 morphometric features (11 lines, eight angles and three ratios) of dogs with and without SM using refined techniques based on previous studies of the Griffon Bruxellois (GB) using Discriminant Function Analysis and ANOVA with post-hoc corrections. Results The analysis identified 14/22 significant traits for SM in the three dog breeds, five of which were identical to those reported for the GB and suggest inclusion of a common aetiology. One ratio, caudal fossa height to the length of the skull base extended to an imaginary point of alignment between the atlas and supraoccipital bones, was common to all three breeds (p values 0.029 to <0.001). Associated with SM were a reduced occipital crest and two acute changes in angulation i) ‘sphenoid flexure’ at the spheno-occipital synchondrosis ii) ‘cervical flexure’ at the foramen magnum allied with medulla oblongata elevation. Comparing dogs with and without SM, each breed had a unique trait: Chihuahua had a smaller angle between the dens, atlas and basioccipital bone (p value < 0.001); Affenpinschers had a smaller distance from atlas to dens (p value 0.009); CKCS had a shorter distance between the spheno-occipital synchondrosis and atlas (p value 0.007). Conclusion The selected morphometries successfully characterised conformational changes in the brain and craniocervical junction that might form the basis of a diagnostic tool for all breeds. The severity of SM involved a spectrum of abnormalities, incurred by changes in both angulation and size that could alter neural parenchyma compliance and/or impede cerebrospinal

  2. Use of Morphometric Mapping to Characterise Symptomatic Chiari-Like Malformation, Secondary Syringomyelia and Associated Brachycephaly in the Cavalier King Charles Spaniel

    Science.gov (United States)

    Cross, Chloe; Griffiths, Sandra; McFadyen, Angus K.; Jovanovik, Jelena; Tauro, Anna; Kibar, Zoha; Driver, Colin J.; La Ragione, Roberto M.; Rusbridge, Clare

    2017-01-01

    Objectives To characterise the symptomatic phenotype of Chiari-like malformation (CM), secondary syringomyelia (SM) and brachycephaly in the Cavalier King Charles Spaniel using morphometric measurements on mid-sagittal Magnetic Resonance images (MRI) of the brain and craniocervical junction. Methods This retrospective study, based on a previous quantitative analysis in the Griffon Bruxellois (GB), used 24 measurements taken on 130 T1-weighted MRI of hindbrain and cervical region. Associated brachycephaly was estimated using 26 measurements, including rostral forebrain flattening and olfactory lobe rotation, on 72 T2-weighted MRI of the whole brain. Both study cohorts were divided into three groups; Control, CM pain and SM and their morphometries compared with each other. Results Fourteen significant traits were identified in the hindbrain study and nine traits in the whole brain study, six of which were similar to the GB and suggest a common aetiology. The Control cohort had the most elliptical brain (p = 0.010), least olfactory bulb rotation (p = 0.003) and a protective angle (p = 0.004) compared to the other groups. The CM pain cohort had the greatest rostral forebrain flattening (p = 0.007), shortest basioccipital (p = 0.019), but a greater distance between the atlas and basioccipital (p = 0.002) which was protective for SM. The SM cohort had two conformation anomalies depending on the severity of craniocervical junction incongruities; i) the proximity of the dens (p <0.001) ii) increased airorhynchy with a smaller, more ventrally rotated olfactory bulb (p <0.001). Both generated ‘concertina’ flexures of the brain and craniocervical junction. Conclusion Morphometric mapping provides a diagnostic tool for quantifying symptomatic CM, secondary SM and their relationship with brachycephaly. It is hypothesized that CM pain is associated with increased brachycephaly and SM can result from different combinations of abnormalities of the forebrain, caudal fossa and

  3. Increase in cerebellar volume in Cavalier King Charles Spaniels with Chiari-like malformation and its role in the development of syringomyelia.

    Directory of Open Access Journals (Sweden)

    Thomas A Shaw

    Full Text Available Previous research in Cavalier King Charles Spaniels (CKCS has found that Chiari-like malformation and syringomyelia (CM/SM are associated with a volume mismatch between the caudal cranial fossa (CCF and the brain parenchyma contained within. The objectives of this study were to i compare cerebellar volume in CKCS (a "high risk' group which frequently develops CM/SM, small breed dogs (medium risk--occasionally develop CM/SM, and Labradors (low risk--CM/SM not reported; ii evaluate a possible association between increased cerebellar volume and CM/SM in CKCS; iii investigate the relationship between increased cerebellar volume and crowding of the cerebellum in the caudal part of the CCF (i.e. the region of the foramen magnum. Volumes of three-dimensional, magnetic resonance imaging derived models of the CCF and cerebellum were obtained from 75 CKCS, 44 small breed dogs, and 31 Labradors. As SM is thought to be a late onset disease process, two subgroups were formed for comparison: 18 CKCS younger than 2 years with SM (CM/SM group and 13 CKCS older than 5 years without SM (CM group. Relative cerebellar volume was defined as the volume of the cerebellum divided by the total volume of brain parenchyma. Our results show that the CKCS has a relatively larger cerebellum than small breed dogs and Labradors and provide evidence that increased cerebellar volume in CKCS is associated with crowding of cerebellum in the caudal part of the CCF. In CKCS there is an association between increased cerebellar volume and SM. These findings have implications for the understanding of the pathological mechanisms of CM/SM, and support the hypothesis that it is a multifactorial disease process governed by increased cerebellar volume and failure of the CCF to reach a commensurate size.

  4. Questionnaire-based behaviour analysis of Cavalier King Charles spaniels with neuropathic pain due to Chiari-like malformation and syringomyelia.

    Science.gov (United States)

    Rutherford, Lynda; Wessmann, Annette; Rusbridge, Clare; McGonnell, Imelda M; Abeyesinghe, Siobhan; Burn, Charlotte; Volk, Holger A

    2012-12-01

    Chiari-like malformation (CM)/syringomyelia (SM) is a disease complex recognised in Cavalier King Charles spaniels (CKCSs) that can lead to neuropathic pain (NeP). In humans, NeP is associated with anxiety, depression and reduced quality of life (QoL). In this study, databases of three specialist veterinary centres were searched and CKCS breed societies and health forums were contacted to identify CKCS with an imaging diagnosis of CM/SM. Owners completed questionnaires on behaviour, signalment, general health status, NeP and QoL. Data were analysed from 122 dogs out of 564 questionnaires completed, after incomplete questionnaires and data from dogs that had other potentially debilitating disease processes were excluded. NeP severity score was significantly and positively correlated with 'stranger-directed' fear (r(S)=0.28), non-social fear (r(S)=0.34), 'separation-related' behaviour (r(S)=0.38), attachment behaviour (r(S)=0.24), excitability (r(S)=0.21) and proxy for pain sensation (r(S)=0.29). Increased NeP was also significantly associated with decreased QoL (r(S)=0.47), ability to settle (r(S)=0.26) and willingness to exercise (r(S)=0.50). Severity of NeP was positively associated with certain fear-associated behaviour and with decreased owner-perceived QoL. Thus, neurobehavioural changes should be considered in the management of NeP in CKCS with CM/SM.

  5. Decreased inward rectifier potassium current IK1 in dystrophin-deficient ventricular cardiomyocytes.

    Science.gov (United States)

    Rubi, Lena; Koenig, Xaver; Kubista, Helmut; Todt, Hannes; Hilber, Karlheinz

    2017-03-04

    Kir2.x channels in ventricular cardiomyocytes (most prominently Kir2.1) account for the inward rectifier potassium current IK1, which controls the resting membrane potential and the final phase of action potential repolarization. Recently it was hypothesized that the dystrophin-associated protein complex (DAPC) is important in the regulation of Kir2.x channels. To test this hypothesis, we investigated potential IK1 abnormalities in dystrophin-deficient ventricular cardiomyocytes derived from the hearts of Duchenne muscular dystrophy mouse models. We found that IK1 was substantially diminished in dystrophin-deficient cardiomyocytes when compared to wild type myocytes. This finding represents the first functional evidence for a significant role of the DAPC in the regulation of Kir2.x channels.

  6. Fetal skeletal muscle progenitors have regenerative capacity after intramuscular engraftment in dystrophin deficient mice.

    Directory of Open Access Journals (Sweden)

    Hiroshi Sakai

    Full Text Available Muscle satellite cells (SCs are stem cells that reside in skeletal muscles and contribute to regeneration upon muscle injury. SCs arise from skeletal muscle progenitors expressing transcription factors Pax3 and/or Pax7 during embryogenesis in mice. However, it is unclear whether these fetal progenitors possess regenerative ability when transplanted in adult muscle. Here we address this question by investigating whether fetal skeletal muscle progenitors (FMPs isolated from Pax3(GFP/+ embryos have the capacity to regenerate muscle after engraftment into Dystrophin-deficient mice, a model of Duchenne muscular dystrophy. The capacity of FMPs to engraft and enter the myogenic program in regenerating muscle was compared with that of SCs derived from adult Pax3(GFP/+ mice. Transplanted FMPs contributed to the reconstitution of damaged myofibers in Dystrophin-deficient mice. However, despite FMPs and SCs having similar myogenic ability in culture, the regenerative ability of FMPs was less than that of SCs in vivo. FMPs that had activated MyoD engrafted more efficiently to regenerate myofibers than MyoD-negative FMPs. Transcriptome and surface marker analyses of these cells suggest the importance of myogenic priming for the efficient myogenic engraftment. Our findings suggest the regenerative capability of FMPs in the context of muscle repair and cell therapy for degenerative muscle disease.

  7. Dystrophin deficiency exacerbates skeletal muscle pathology in dysferlin-null mice

    Directory of Open Access Journals (Sweden)

    Han Renzhi

    2011-12-01

    Full Text Available Abstract Background Mutations in the genes coding for either dystrophin or dysferlin cause distinct forms of muscular dystrophy. Dystrophin links the cytoskeleton to the sarcolemma through direct interaction with β-dystroglycan. This link extends to the extracellular matrix by β-dystroglycan's interaction with α-dystroglycan, which binds extracellular matrix proteins, including laminin α2, agrin and perlecan, that possess laminin globular domains. The absence of dystrophin disrupts this link, leading to compromised muscle sarcolemmal integrity. Dysferlin, on the other hand, plays an important role in the Ca2+-dependent membrane repair of damaged sarcolemma in skeletal muscle. Because dysferlin and dystrophin play different roles in maintaining muscle cell integrity, we hypothesized that disrupting sarcolemmal integrity with dystrophin deficiency would exacerbate the pathology in dysferlin-null mice and allow further characterization of the role of dysferlin in skeletal muscle. Methods To test our hypothesis, we generated dystrophin/dysferlin double-knockout (DKO mice by breeding mdx mice with dysferlin-null mice and analyzed the effects of a combined deficiency of dysferlin and dystrophin on muscle pathology and sarcolemmal integrity. Results The DKO mice exhibited more severe muscle pathology than either mdx mice or dysferlin-null mice, and, importantly, the onset of the muscle pathology occurred much earlier than it did in dysferlin-deficient mice. The DKO mice showed muscle pathology of various skeletal muscles, including the mandible muscles, as well as a greater number of regenerating muscle fibers, higher serum creatine kinase levels and elevated Evans blue dye uptake into skeletal muscles. Lengthening contractions caused similar force deficits, regardless of dysferlin expression. However, the rate of force recovery within 45 minutes following lengthening contractions was hampered in DKO muscles compared to mdx muscles or dysferlin

  8. Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.

    Science.gov (United States)

    Kornegay, Joe N; Bogan, Daniel J; Bogan, Janet R; Dow, Jennifer L; Wang, Jiahui; Fan, Zheng; Liu, Naili; Warsing, Leigh C; Grange, Robert W; Ahn, Mihye; Balog-Alvarez, Cynthia J; Cotten, Steven W; Willis, Monte S; Brinkmeyer-Langford, Candice; Zhu, Hongtu; Palandra, Joe; Morris, Carl A; Styner, Martin A; Wagner, Kathryn R

    2016-01-01

    Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a less severe phenotype with greater total mass and strength and less fibrosis and fatty replacement of muscles than mdx mice with wild-type myostatin expression. Dogs with golden retriever muscular dystrophy (GRMD) have previously been noted to have increased muscle mass and reduced fibrosis after systemic postnatal myostatin inhibition. Based partly on these results, myostatin inhibitors are in development for use in human muscular dystrophies. However, persisting concerns regarding the effects of long-term and profound myostatin inhibition will not be easily or imminently answered in clinical trials. To address these concerns, we developed a canine (GRippet) model by crossbreeding dystrophin-deficient GRMD dogs with Mstn-heterozygous (Mstn (+/-)) whippets. A total of four GRippets (dystrophic and Mstn (+/-)), three GRMD (dystrophic and Mstn wild-type) dogs, and three non-dystrophic controls from two litters were evaluated. Myostatin messenger ribonucleic acid (mRNA) and protein levels were downregulated in both GRMD and GRippet dogs. GRippets had more severe postural changes and larger (more restricted) maximal joint flexion angles, apparently due to further exaggeration of disproportionate effects on muscle size. Flexors such as the cranial sartorius were more hypertrophied on magnetic resonance imaging (MRI) in the GRippets, while extensors, including the quadriceps femoris, underwent greater atrophy. Myostatin protein levels negatively correlated with relative cranial sartorius muscle cross-sectional area on MRI, supporting a role in disproportionate muscle size. Activin receptor type IIB (ActRIIB) expression was higher in dystrophic versus control dogs, consistent with physiologic feedback between myostatin and ActRIIB. However, there was no

  9. Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery

    Directory of Open Access Journals (Sweden)

    Xuan Guan

    2014-03-01

    Full Text Available The ability to extract somatic cells from a patient and reprogram them to pluripotency opens up new possibilities for personalized medicine. Induced pluripotent stem cells (iPSCs have been employed to generate beating cardiomyocytes from a patient's skin or blood cells. Here, iPSC methods were used to generate cardiomyocytes starting from the urine of a patient with Duchenne muscular dystrophy (DMD. Urine was chosen as a starting material because it contains adult stem cells called urine-derived stem cells (USCs. USCs express the canonical reprogramming factors c-myc and klf4, and possess high telomerase activity. Pluripotency of urine-derived iPSC clones was confirmed by immunocytochemistry, RT-PCR and teratoma formation. Urine-derived iPSC clones generated from healthy volunteers and a DMD patient were differentiated into beating cardiomyocytes using a series of small molecules in monolayer culture. Results indicate that cardiomyocytes retain the DMD patient's dystrophin mutation. Physiological assays suggest that dystrophin-deficient cardiomyocytes possess phenotypic differences from normal cardiomyocytes. These results demonstrate the feasibility of generating cardiomyocytes from a urine sample and that urine-derived cardiomyocytes retain characteristic features that might be further exploited for mechanistic studies and drug discovery.

  10. Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs

    Directory of Open Access Journals (Sweden)

    Voit Thomas

    2011-04-01

    Full Text Available Abstract Background This study aimed to measure the gait abnormalities in GRMD (Golden retriever muscular dystrophy dogs during growth and disease progression using an ambulatory gait analyzer (3D-accelerometers as a possible tool to assess the effects of a therapeutic intervention. Methods Six healthy and twelve GRMD dogs were evaluated twice monthly, from the age of two to nine months. The evolution of each gait variable previously shown to be modified in control and dystrophin-deficient adults was assessed using two-ways variance analysis (age, clinical status with repeated measurements. A principal component analysis (PCA was applied to perfect multivariate data interpretation. Results Speed, stride length, total power and force significantly already decreased (p Conclusion The gait variables measured by the accelerometers were sensitive to early detect and follow the gait disorders and mirrored the heterogeneity of clinical presentations, giving sense to monitor gait in GRMD dogs during progression of the disease and pre-clinical therapeutic trials.

  11. Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO.

    Science.gov (United States)

    Yin, Haifang; Moulton, Hong M; Betts, Corinne; Merritt, Thomas; Seow, Yiqi; Ashraf, Shirin; Wang, Qingsong; Boutilier, Jordan; Wood, Matthew Ja

    2010-10-01

    Splice modulation using antisense oligonucleotides (AOs) has been shown to yield targeted exon exclusion to restore the open reading frame and generate truncated but partially functional dystrophin protein. This has been successfully demonstrated in dystrophin-deficient mdx mice and in Duchenne muscular dystrophy (DMD) patients. However, DMD is a systemic disease; successful therapeutic exploitation of this approach will therefore depend on effective systemic delivery of AOs to all affected tissues. We have previously shown the potential of a muscle-specific/arginine-rich chimeric peptide-phosphorodiamidate morpholino (PMO) conjugate, but its long-term activity, optimized dosing regimen, capacity for functional correction and safety profile remain to be established. Here, we report the results of this chimeric peptide-PMO conjugate in the mdx mouse using low doses (3 and 6 mg/kg) administered via a 6 biweekly systemic intravenous injection protocol. We show 100% dystrophin-positive fibers and near complete correction of the dystrophin transcript defect in all peripheral muscle groups, with restoration of 50% dystrophin protein over 12 weeks, leading to correction of the DMD pathological phenotype and restoration of muscle function in the absence of detectable toxicity or immune response. Chimeric muscle-specific/cell-penetrating peptides therefore represent highly promising agents for systemic delivery of splice-correcting PMO oligomers for DMD therapy.

  12. Proteomic Profiling of the Dystrophin-Deficient mdx Phenocopy of Dystrophinopathy-Associated Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Ashling Holland

    2014-01-01

    Full Text Available Cardiorespiratory complications are frequent symptoms of Duchenne muscular dystrophy, a neuromuscular disorder caused by primary abnormalities in the dystrophin gene. Loss of cardiac dystrophin initially leads to changes in dystrophin-associated glycoproteins and subsequently triggers secondarily sarcolemmal disintegration, fibre necrosis, fibrosis, fatty tissue replacement, and interstitial inflammation. This results in progressive cardiac disease, which is the cause of death in a considerable number of patients afflicted with X-linked muscular dystrophy. In order to better define the molecular pathogenesis of this type of cardiomyopathy, several studies have applied mass spectrometry-based proteomics to determine proteome-wide alterations in dystrophinopathy-associated cardiomyopathy. Proteomic studies included both gel-based and label-free mass spectrometric surveys of dystrophin-deficient heart muscle from the established mdx animal model of dystrophinopathy. Comparative cardiac proteomics revealed novel changes in proteins associated with mitochondrial energy metabolism, glycolysis, signaling, iron binding, antibody response, fibre contraction, basal lamina stabilisation, and cytoskeletal organisation. This review summarizes the importance of studying cardiomyopathy within the field of muscular dystrophy research, outlines key features of the mdx heart and its suitability as a model system for studying cardiac pathogenesis, and discusses the impact of recent proteomic findings for exploring molecular and cellular aspects of cardiac abnormalities in inherited muscular dystrophies.

  13. Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice

    Directory of Open Access Journals (Sweden)

    Sali Arpana

    2011-05-01

    Full Text Available Abstract Background Cardiomyopathy in Duchenne muscular dystrophy (DMD is an increasing cause of death in patients. The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle. Treatment of cardiomyocyte membrane instability could help prevent cardiomyopathy. Methods Three month old female mdx mice were exposed to the β1 receptor agonist isoproterenol subcutaneously and treated with the non-ionic tri-block copolymer Poloxamer P188 (P188 (460 mg/kg/dose i.p. daily. Cardiac function was assessed using high frequency echocardiography. Tissue was evaluated with Evans Blue Dye (EBD and picrosirius red staining. Results BL10 control mice tolerated 30 mg/kg/day of isoproterenol for 4 weeks while death occurred in mdx mice at 30, 15, 10, 5 and 1 mg/kg/day within 24 hours. Mdx mice tolerated a low dose of 0.5 mg/kg/day. Isoproterenol exposed mdx mice showed significantly increased heart rates (p Conclusions This model suggests that chronic intermittent intraperitoneal P188 treatment can prevent isoproterenol induced cardiomyopathy in dystrophin deficient mdx mice.

  14. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

    Directory of Open Access Journals (Sweden)

    Jahnke Vanessa E

    2012-08-01

    Full Text Available Abstract Background Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiation; enhancing mitochondrial activity with exercise mimetics (AMPK and PPAR-delta agonists increases muscle function and inhibits muscle wasting in healthy mice. We therefore asked whether metabolic remodeling agents that increase mitochondrial activity would improve muscle function in mdx mice. Methods Twelve-week-old mdx mice were treated with two different metabolic remodeling agents (GW501516 and AICAR, separately or in combination, for 4 weeks. Extensive systematic behavioral, functional, histological, biochemical, and molecular tests were conducted to assess the drug(s' effects. Results We found a gain in body and muscle weight in all treated mice. Histologic examination showed a decrease in muscle inflammation and in the number of fibers with central nuclei and an increase in fibers with peripheral nuclei, with significantly fewer activated satellite cells and regenerating fibers. Together with an inhibition of FoXO1 signaling, these results indicated that the treatments reduced ongoing muscle damage. Conclusions The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient mdx mice.

  15. Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts.

    Science.gov (United States)

    Barnabei, Matthew S; Metzger, Joseph M

    2012-01-01

    Duchenne muscular dystrophy (DMD) is a progressive and fatal disease of muscle wasting caused by loss of the cytoskeletal protein dystrophin. In the heart, DMD results in progressive cardiomyopathy and dilation of the left ventricle through mechanisms that are not fully understood. Previous reports have shown that loss of dystrophin causes sarcolemmal instability and reduced mechanical compliance of isolated cardiac myocytes. To expand upon these findings, here we have subjected the left ventricles of dystrophin-deficient mdx hearts to mechanical stretch. Unexpectedly, isolated mdx hearts showed increased left ventricular (LV) compliance compared to controls during stretch as LV volume was increased above normal end diastolic volume. During LV chamber distention, sarcomere lengths increased similarly in mdx and WT hearts despite greater excursions in volume of mdx hearts. This suggests that the mechanical properties of the intact heart cannot be modeled as a simple extrapolation of findings in single cardiac myocytes. To explain these findings, a model is proposed in which disruption of the dystrophin-glycoprotein complex perturbs cell-extracellular matrix contacts and promotes the apparent slippage of myocytes past each other during LV distension. In comparison, similar increases in LV compliance were obtained in isolated hearts from β-sarcoglycan-null and laminin-α(2) mutant mice, but not in dysferlin-null mice, suggesting that increased whole-organ compliance in mdx mice is a specific effect of disrupted cell-extracellular matrix contacts and not a general consequence of cardiomyopathy via membrane defect processes. Collectively, these findings suggest a novel and cell-death independent mechanism for the progressive pathological LV dilation that occurs in DMD.

  16. Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts.

    Directory of Open Access Journals (Sweden)

    Matthew S Barnabei

    Full Text Available Duchenne muscular dystrophy (DMD is a progressive and fatal disease of muscle wasting caused by loss of the cytoskeletal protein dystrophin. In the heart, DMD results in progressive cardiomyopathy and dilation of the left ventricle through mechanisms that are not fully understood. Previous reports have shown that loss of dystrophin causes sarcolemmal instability and reduced mechanical compliance of isolated cardiac myocytes. To expand upon these findings, here we have subjected the left ventricles of dystrophin-deficient mdx hearts to mechanical stretch. Unexpectedly, isolated mdx hearts showed increased left ventricular (LV compliance compared to controls during stretch as LV volume was increased above normal end diastolic volume. During LV chamber distention, sarcomere lengths increased similarly in mdx and WT hearts despite greater excursions in volume of mdx hearts. This suggests that the mechanical properties of the intact heart cannot be modeled as a simple extrapolation of findings in single cardiac myocytes. To explain these findings, a model is proposed in which disruption of the dystrophin-glycoprotein complex perturbs cell-extracellular matrix contacts and promotes the apparent slippage of myocytes past each other during LV distension. In comparison, similar increases in LV compliance were obtained in isolated hearts from β-sarcoglycan-null and laminin-α(2 mutant mice, but not in dysferlin-null mice, suggesting that increased whole-organ compliance in mdx mice is a specific effect of disrupted cell-extracellular matrix contacts and not a general consequence of cardiomyopathy via membrane defect processes. Collectively, these findings suggest a novel and cell-death independent mechanism for the progressive pathological LV dilation that occurs in DMD.

  17. Differential expression of myosin heavy chain isoforms in the masticatory muscles of dystrophin-deficient mice.

    Science.gov (United States)

    Spassov, Alexander; Gredes, Tomasz; Gedrange, Tomasz; Lucke, Silke; Morgenstern, Sven; Pavlovic, Dragan; Kunert-Keil, Christiane

    2011-12-01

    The dystrophin-deficient mouse (mdx) is a homologue animal model of Duchenne muscular dystrophy (DMD) and is characterized by slowly progressive muscle weakness accompanied by changes in myosin heavy chain (MyHC) composition. It is likely that the masticatory muscles undergo similar changes. The aim of this study was to examine the masticatory muscles (masseter, temporal, tongue, and soleus) of 100-day-old mdx and control mice (n = 8-10), and the fibre type distribution (by immunohistochemistry) as well as the expression of the corresponding MyHC messenger RNA (mRNA) (protein and mRNA expression, using Western blot or quantitative real-time polymerase chain reaction (RT-PCR)). Immunohistochemistry and western blot analysis revealed that the masticatory muscles in the control and mdx mice consisted mainly of type 2 fibres, whereas soleus muscle consisted of both type 1 and 2 fibres. In the masseter muscle, the mRNA in mdx mice was not different from that found in the controls. However, the mRNA content of the MyHC-2b isoform in mdx mice was lower in comparison with the controls in the temporal muscle [11.9 versus 36.9 per cent; P muscle (65.7 versus 73.8 per cent; P muscle was lower than in the controls (25.9 versus 30.8 per cent; P muscles of mdx mice may lead to changed fibre type composition. The different MyHC gene expression in mdx mice masticatory muscles may be seen as an adaptive mechanism to muscular dystrophy.

  18. The proton pump inhibitor lansoprazole improves the skeletal phenotype in dystrophin deficient mdx mice.

    Directory of Open Access Journals (Sweden)

    Arpana Sali

    Full Text Available BACKGROUND: In Duchenne muscular dystrophy (DMD, loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential, which modifies excitation-contraction coupling and increases proinflammatory/apoptotic signaling cascades. Although glucocorticoids remain the standard of care for the treatment of DMD, there is a need to investigate the efficacy of other pharmacological agents targeting the involvement of imbalances in ion flux on dystrophic pathology. METHODOLOGY/PRINCIPAL FINDINGS: We designed a preclinical trial to investigate the effects of lansoprazole (LANZO administration, a proton pump inhibitor, on the dystrophic muscle phenotype in dystrophin deficient (mdx mice. Eight to ten week-old female mice were assigned to one of four treatment groups (n = 12 per group: (1 vehicle control; (2 5 mg/kg/day LANZO; (3 5 mg/kg/day prednisolone; and (4 combined treatment of 5 mg/kg/day prednisolone (PRED and 5 mg/kg/day LANZO. Treatment was administered orally 5 d/wk for 3 months. At the end of the study, behavioral (Digiscan and functional outcomes (grip strength and Rotarod were assessed prior to sacrifice. After sacrifice, body, tissue and organ masses, muscle histology, in vitro muscle force, and creatine kinase levels were measured. Mice in the combined treatment groups displayed significant reductions in the number of degenerating muscle fibers and number of inflammatory foci per muscle field relative to vehicle control. Additionally, mice in the combined treatment group displayed less of a decline in normalized forelimb and hindlimb grip strength and declines in in vitro EDL force after repeated eccentric contractions. CONCLUSIONS/SIGNIFICANCE: Together our findings suggest that combined treatment of LANZO and prednisolone attenuates some components of dystrophic pathology in mdx mice. Our findings

  19. Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers.

    Science.gov (United States)

    Miyazaki, Daigo; Nakamura, Akinori; Fukushima, Kazuhiro; Yoshida, Kunihiro; Takeda, Shin'ichi; Ikeda, Shu-ichi

    2011-05-01

    Matrix metalloproteases (MMPs) are a family of endopeptidases classified into subgroups based on substrate preference in normal physiological processes such as embryonic development and tissue remodeling, as well as in various disease processes via degradation of extracellular matrix components. Among the MMPs, MMP-9 and MMP-2 have been reported to be up-regulated in skeletal muscles in the lethal X-linked muscle disorder Duchenne muscular dystrophy (DMD), which is caused by loss of dystrophin. A recent study showed that deletion of the MMP9 gene in mdx, a mouse model for DMD, improved skeletal muscle pathology and function; however, the role of MMP-2 in the dystrophin-deficient muscle is not well known. In this study, we aimed at verifying the role of MMP-2 in the dystrophin-deficient muscle by using mdx mice with genetic ablation of MMP-2 (mdx/MMP-2(-/-)). We found impairment of regenerated muscle fiber growth with reduction of angiogenesis in mdx/MMP-2(-/-) mice at 3 months of age. Expression of vascular endothelial growth factor-A (VEGF-A), an important angiogenesis-related factor, decreased in mdx/MMP-2(-/-) mice at 3 months of age. MMP-2 had not a critical role in the degradation of dystrophin-glycoprotein complex (DGC) components such as β-dystroglycan and β-sarcoglycan in the regeneration process of the dystrophic muscle. Accordingly, MMP-2 may be essential for growth of regenerated muscle fibers through VEGF-associated angiogenesis in the dystrophin-deficient skeletal muscle.

  20. Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins

    DEFF Research Database (Denmark)

    Moghadaszadeh, Behzad; Albrechtsen, Reidar; Guo, Ling T;

    2003-01-01

    , and suggested that significant changes in mdx/ADAM12 muscle might occur post-transcriptionally. Indeed, by immunostaining and immunoblotting we found an approximately 2-fold increase in expression, and distinct extrasynaptic localization, of alpha 7B integrin and utrophin, the functional homolog of dystrophin....... The expression of the dystrophin-associated glycoproteins was also increased. In conclusion, these results demonstrate a novel way to alleviate dystrophin deficiency in mice, and may stimulate the development of new approaches to compensate for dystrophin deficiency in animals and humans....

  1. Nestin expression in end-stage disease in dystrophin-deficient heart: implications for regeneration from endogenous cardiac stem cells.

    Science.gov (United States)

    Berry, Suzanne E; Andruszkiewicz, Peter; Chun, Ju Lan; Hong, Jun

    2013-11-01

    Nestin(+) cardiac stem cells differentiate into striated cells following myocardial infarct. Transplantation of exogenous stem cells into myocardium of a murine model for Duchenne muscular dystrophy (DMD) increased proliferation of endogenous nestin(+) stem cells and resulted in the appearance of nestin(+) striated cells. This correlated with, and may be responsible for, prevention of dilated cardiomyopathy. We examined nestin(+) stem cells in the myocardium of dystrophin/utrophin-deficient (mdx/utrn(-/-)) mice, a model for DMD. We found that 92% of nestin(+) interstitial cells expressed Flk-1, a marker present on cardiac progenitor cells that differentiate into the cardiac lineage, and that a subset expressed Sca-1, present on adult cardiac cells that become cardiomyocytes. Nestin(+) interstitial cells maintained expression of Flk-1 but lost Sca-1 expression with age and were present in lower numbers in dystrophin-deficient heart than in wild-type heart. Unexpectedly, large clusters of nestin(+) striated cells ranging in size from 20 to 250 cells and extending up to 500 μm were present in mdx/utrn(-/-) heart near the end stage of disease. These cells were also present in dystrophin-deficient mdx/utrn(+/-) and mdx heart but not wild-type heart. Nestin(+) striated cells expressed cardiac troponin I, desmin, and Connexin 43 and correlated with proinflammatory CD68(+) macrophages. Elongated nestin(+) interstitial cells with striations were observed that did not express Flk-1 or the late cardiac marker cardiac troponin I but strongly expressed the early cardiac marker desmin. Nestin was also detected in endothelial and smooth muscle cells. These data indicate that new cardiomyocytes form in dystrophic heart, and nestin(+) interstitial cells may generate them in addition to other cells of the cardiac lineage.

  2. Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse.

    Directory of Open Access Journals (Sweden)

    Christopher F Spurney

    Full Text Available Thymosin beta-4 (Tbeta4 is a ubiquitous protein with many properties relating to cell proliferation and differentiation that promotes wound healing and modulates inflammatory mediators. We studied the effects of chronic administration of Tbeta4 on the skeletal and cardiac muscle of dystrophin deficient mdx mice, the mouse model of Duchenne muscular dystrophy. Female wild type (C57BL10/ScSnJ and mdx mice, 8-10 weeks old, were treated with 150 microg of Tbeta4 twice a week for 6 months. To promote muscle pathology, mice were exercised for 30 minutes twice a week. Skeletal and cardiac muscle function were assessed via grip strength and high frequency echocardiography. Localization of Tbeta4 and amount of fibrosis were quantified using immunohistochemistry and Gomori's tri-chrome staining, respectively. Mdx mice treated with Tbeta4 showed a significant increase in skeletal muscle regenerating fibers compared to untreated mdx mice. Tbeta4 stained exclusively in the regenerating fibers of mdx mice. Although untreated mdx mice had significantly decreased skeletal muscle strength compared to untreated wild type, there were no significant improvements in mdx mice after treatment. Systolic cardiac function, measured as percent shortening fraction, was decreased in untreated mdx mice compared to untreated wild type and there was no significant difference after treatment in mdx mice. Skeletal and cardiac muscle fibrosis were also significantly increased in untreated mdx mice compared to wild type, but there was no significant improvement in treated mdx mice. In exercised dystrophin deficient mice, chronic administration of Tbeta4 increased the number of regenerating fibers in skeletal muscle and could have a potential role in treatment of skeletal muscle disease in Duchenne muscular dystrophy.

  3. Motor physical therapy affects muscle collagen type I and decreases gait speed in dystrophin-deficient dogs.

    Directory of Open Access Journals (Sweden)

    Thaís P Gaiad

    Full Text Available Golden Retriever Muscular Dystrophy (GRMD is a dystrophin-deficient canine model genetically homologous to Duchenne Muscular Dystrophy (DMD in humans. Muscular fibrosis secondary to cycles of degeneration/regeneration of dystrophic muscle tissue and muscular weakness leads to biomechanical adaptation that impairs the quality of gait. Physical therapy (PT is one of the supportive therapies available for DMD, however, motor PT approaches have controversial recommendations and there is no consensus regarding the type and intensity of physical therapy. In this study we investigated the effect of physical therapy on gait biomechanics and muscular collagen deposition types I and III in dystrophin-deficient dogs. Two dystrophic dogs (treated dogs-TD underwent a PT protocol of active walking exercise, 3×/week, 40 minutes/day, 12 weeks. Two dystrophic control dogs (CD maintained their routine of activities of daily living. At t0 (pre and t1 (post-physical therapy, collagen type I and III were assessed by immunohistochemistry and gait biomechanics were analyzed. Angular displacement of shoulder, elbow, carpal, hip, stifle and tarsal joint and vertical (Fy, mediolateral (Fz and craniocaudal (Fx ground reaction forces (GRF were assessed. Wilcoxon test was used to verify the difference of biomechanical variables between t0 and t1, considering p<.05. Type I collagen of endomysium suffered the influence of PT, as well as gait speed that had decreased from t0 to t1 (p<.000. The PT protocol employed accelerates morphological alterations on dystrophic muscle and promotes a slower velocity of gait. Control dogs which maintained their routine of activities of daily living seem to have found a better balance between movement and preservation of motor function.

  4. Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs.

    Science.gov (United States)

    Nghiem, Peter P; Hoffman, Eric P; Mittal, Priya; Brown, Kristy J; Schatzberg, Scott J; Ghimbovschi, Svetlana; Wang, Zuyi; Kornegay, Joe N

    2013-11-01

    Both Duchenne and golden retriever muscular dystrophy (GRMD) are caused by dystrophin deficiency. The Duchenne muscular dystrophy sartorius muscle and orthologous GRMD cranial sartorius (CS) are relatively spared/hypertrophied. We completed hierarchical clustering studies to define molecular mechanisms contributing to this differential involvement and their role in the GRMD phenotype. GRMD dogs with larger CS muscles had more severe deficits, suggesting that selective hypertrophy could be detrimental. Serial biopsies from the hypertrophied CS and other atrophied muscles were studied in a subset of these dogs. Myostatin showed an age-dependent decrease and an inverse correlation with the degree of GRMD CS hypertrophy. Regulators of myostatin at the protein (AKT1) and miRNA (miR-539 and miR-208b targeting myostatin mRNA) levels were altered in GRMD CS, consistent with down-regulation of myostatin signaling, CS hypertrophy, and functional rescue of this muscle. mRNA and proteomic profiling was used to identify additional candidate genes associated with CS hypertrophy. The top-ranked network included α-dystroglycan and like-acetylglucosaminyltransferase. Proteomics demonstrated increases in myotrophin and spectrin that could promote hypertrophy and cytoskeletal stability, respectively. Our results suggest that multiple pathways, including decreased myostatin and up-regulated miRNAs, α-dystroglycan/like-acetylglucosaminyltransferase, spectrin, and myotrophin, contribute to hypertrophy and functional sparing of the CS. These data also underscore the muscle-specific responses to dystrophin deficiency and the potential deleterious effects of differential muscle involvement. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  5. Proteasome inhibitor (MG132 rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx5cv mice

    Directory of Open Access Journals (Sweden)

    Jean-Sebastien eRougier

    2013-03-01

    Full Text Available The cardiac voltage-gated sodium channel, Nav1.5, plays a central role in cardiac excitability and impulse propagation and associates with the dystrophin multiprotein complex (DMC at the lateral membrane of cardiomyocytes. It was previously shown that Nav1.5 protein content and the sodium current (INa were both decreased in cardiomyocytes of dystrophin-deficient mdx5cv mice. In this study, wild-type (WT and mdx5cv mice were treated for 7 days with the proteasome inhibitor MG132 (10 µg/Kg/24 h using implanted osmotic mini pumps. MG132 rescued both the total amount of Nav1.5 protein and INa but, unlike in previous studies, de novo expression of dystrophin was not observed in skeletal or cardiac muscle. This study suggests that the reduced expression of Nav1.5 in dystrophin-deficient cells is dependent on proteasomal degradation.

  6. Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins

    Directory of Open Access Journals (Sweden)

    Caroline Lewis

    2010-01-01

    Full Text Available Although Duchenne muscular dystrophy is primarily classified as a neuromuscular disease, cardiac complications play an important role in the course of this X-linked inherited disorder. The pathobiochemical steps causing a progressive decline in the dystrophic heart are not well understood. We therefore carried out a fluorescence difference in-gel electrophoretic analysis of 9-month-old dystrophin-deficient versus age-matched normal heart, using the established MDX mouse model of muscular dystrophy-related cardiomyopathy. Out of 2,509 detectable protein spots, 79 2D-spots showed a drastic differential expression pattern, with the concentration of 3 proteins being increased, including nucleoside diphosphate kinase and lamin-A/C, and of 26 protein species being decreased, including ATP synthase, fatty acid binding-protein, isocitrate dehydrogenase, NADH dehydrogenase, porin, peroxiredoxin, adenylate kinase, tropomyosin, actin, and myosin light chains. Hence, the lack of cardiac dystrophin appears to trigger a generally perturbed protein expression pattern in the MDX heart, affecting especially energy metabolism and contractile proteins.

  7. Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.

    Directory of Open Access Journals (Sweden)

    Meghna Pant

    Full Text Available The utrophin-dystrophin deficient (DKO mouse model has been widely used to understand the progression of Duchenne muscular dystrophy (DMD. However, it is unclear as to what extent muscle pathology affects metabolism. Therefore, the present study was focused on understanding energy expenditure in the whole animal and in isolated extensor digitorum longus (EDL muscle and to determine changes in metabolic enzymes. Our results show that the 8 week-old DKO mice consume higher oxygen relative to activity levels. Interestingly the EDL muscle from DKO mouse consumes higher oxygen per unit integral force, generates less force and performs better in the presence of pyruvate thus mimicking a slow twitch muscle. We also found that the expression of hexokinase 1 and pyruvate kinase M2 was upregulated several fold suggesting increased glycolytic flux. Additionally, there is a dramatic increase in dynamin-related protein 1 (Drp 1 and mitofusin 2 protein levels suggesting increased mitochondrial fission and fusion, a feature associated with increased energy demand and altered mitochondrial dynamics. Collectively our studies point out that the dystrophic disease has caused significant changes in muscle metabolism. To meet the increased energetic demand, upregulation of metabolic enzymes and regulators of mitochondrial fusion and fission is observed in the dystrophic muscle. A better understanding of the metabolic demands and the accompanied alterations in the dystrophic muscle can help us design improved intervention therapies along with existing drug treatments for the DMD patients.

  8. Early right ventricular fibrosis and reduction in biventricular cardiac reserve in the dystrophin-deficient mdx heart.

    Science.gov (United States)

    Meyers, Tatyana A; Townsend, DeWayne

    2015-02-15

    Duchenne muscular dystrophy (DMD) is a progressive disease of striated muscle deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant because they result in the leading causes of death in DMD patients. Despite the clinical and physiological significance of these systems, little has been done to understand the cardiorespiratory interaction in DMD. We show here that prior to the onset of global cardiac dysfunction, dystrophin-deficient mdx mice have increased cardiac fibrosis with the right ventricle being particularly affected. Using a novel biventricular cardiac catheterization technique coupled with cardiac stress testing, we demonstrate that both the right and left ventricles have significant reductions in both systolic and diastolic function in response to dobutamine. Unstimulated cardiac function is relatively normal except for a significant reduction in the ventricular pressure transient duration compared with controls. These biventricular analyses also reveal the absence of a dobutamine-induced increase in isovolumic relaxation in the right ventricle of control hearts. Simultaneous assessment of biventricular pressure demonstrates a dobutamine-dependent enhancement of coupling between the ventricles in control mice, which is absent in mdx mice. Furthermore, studies probing the passive-extension properties of the left ventricle demonstrate that the mdx heart is significantly more compliant compared with age-matched C57BL/10 hearts, which have an age-dependent stiffening that is completely absent from dystrophic hearts. These new results indicate that right ventricular fibrosis is an early indicator of the development of dystrophic cardiomyopathy, suggesting a mechanism by which respiratory insufficiency may accelerate the development of heart failure in DMD.

  9. Defects in mitochondrial ATP synthesis in dystrophin-deficient mdx skeletal muscles may be caused by complex I insufficiency.

    Directory of Open Access Journals (Sweden)

    Emma Rybalka

    Full Text Available Duchenne Muscular Dystrophy is a chronic, progressive and ultimately fatal skeletal muscle wasting disease characterised by sarcolemmal fragility and intracellular Ca2+ dysregulation secondary to the absence of dystrophin. Mounting literature also suggests that the dysfunction of key energy systems within the muscle may contribute to pathological muscle wasting by reducing ATP availability to Ca2+ regulation and fibre regeneration. No study to date has biochemically quantified and contrasted mitochondrial ATP production capacity by dystrophic mitochondria isolated from their pathophysiological environment such to determine whether mitochondria are indeed capable of meeting this heightened cellular ATP demand, or examined the effects of an increasing extramitochondrial Ca2+ environment. Using isolated mitochondria from the diaphragm and tibialis anterior of 12 week-old dystrophin-deficient mdx and healthy control mice (C57BL10/ScSn we have demonstrated severely depressed Complex I-mediated mitochondrial ATP production rate in mdx mitochondria that occurs irrespective of the macronutrient-derivative substrate combination fed into the Kreb's cycle, and, which is partially, but significantly, ameliorated by inhibition of Complex I with rotenone and stimulation of Complex II-mediated ATP-production with succinate. There was no difference in the MAPR response of mdx mitochondria to increasing extramitochondrial Ca2+ load in comparison to controls, and 400 nM extramitochondrial Ca2+ was generally shown to be inhibitory to MAPR in both groups. Our data suggests that DMD pathology is exacerbated by a Complex I deficiency, which may contribute in part to the severe reductions in ATP production previously observed in dystrophic skeletal muscle.

  10. Increased constitutive nitric oxide production by whole body periodic acceleration ameliorates alterations in cardiomyocytes associated with utrophin/dystrophin deficiency.

    Science.gov (United States)

    Lopez, Jose R; Kolster, Juan; Zhang, Rui; Adams, Jose

    2017-07-01

    Duchenne Muscular Dystrophy (DMD) cardiomyopathy is a progressive lethal disease caused by the lack of the dystrophin protein in the heart. The most widely used animal model of DMD is the dystrophin-deficient mdx mouse; however, these mice exhibit a mild dystrophic phenotype with heart failure only late in life. In contrast, mice deficient for both dystrophin and utrophin (mdx/utrn(-/-), or dKO) can be used to model severe DMD cardiomyopathy where pathophysiological indicators of heart failure are detectable by 8-10weeks of age. Nitric oxide (NO) is an important signaling molecule involved in vital functions of regulating rhythm, contractility, and microcirculation of the heart, and constitutive NO production affects the function of proteins involved in excitation-contraction coupling. In this study, we explored the efficacy of enhancing NO production as a therapeutic strategy for treating DMD cardiomyopathy using the dKO mouse model of DMD. Specifically, NO production was induced via whole body periodic acceleration (pGz), a novel non-pharmacologic intervention which enhances NO synthase (NOS) activity through sinusoidal motion of the body in a headward-footward direction, introducing pulsatile shear stress to the vascular endothelium and cardiomyocyte plasma membrane. Male dKO mice were randomized at 8weeks of age to receive daily pGz (480cpm, Gz±3.0m/s(2), 1h/d) for 4weeks or no treatment, and a separate age-matched group of WT animals (pGz-treated and untreated) served as non-diseased controls. At the conclusion of the protocol, cardiomyocytes from untreated dKO animals had, respectively, 4.3-fold and 3.5-fold higher diastolic resting concentration of Ca(2+) ([Ca(2+)]d) and Na(+) ([Na(+)]d) compared to WT, while pGz treatment significantly reduced these levels. For dKO cardiomyocytes, pGz treatment also improved the depressed contractile function, decreased oxidative stress, blunted the elevation in calpain activity, and mitigated the abnormal increase in [Ca

  11. Dystrophin-Deficient Cardiomyopathy.

    Science.gov (United States)

    Kamdar, Forum; Garry, Daniel J

    2016-05-31

    Dystrophinopathies are a group of distinct neuromuscular diseases that result from mutations in the structural cytoskeletal Dystrophin gene. Dystrophinopathies include Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), X-linked dilated cardiomyopathy, as well as DMD and BMD female carriers. The primary presenting symptom in most dystrophinopathies is skeletal muscle weakness. However, cardiac muscle is also a subtype of striated muscle and is similarly affected in many of the muscular dystrophies. Cardiomyopathies associated with dystrophinopathies are an increasingly recognized manifestation of these neuromuscular disorders and contribute significantly to their morbidity and mortality. Recent studies suggest that these patient populations would benefit from cardiovascular therapies, annual cardiovascular imaging studies, and close follow-up with cardiovascular specialists. Moreover, patients with DMD and BMD who develop end-stage heart failure may benefit from the use of advanced therapies. This review focuses on the pathophysiology, cardiac involvement, and treatment of cardiomyopathy in the dystrophic patient. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  12. Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy.

    Directory of Open Access Journals (Sweden)

    Elżbieta Krasowska

    Full Text Available Duchenne muscular dystrophy (DMD is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder. Convergent lines of evidence point to an important role for dystrophin in regulating the molecular machinery of central synapses. The clustering of neurotransmitter receptors at inhibitory synapses, thus impacting on synaptic transmission, is of particular significance. However, less is known about the role of dystrophin in influencing the precise expression patterns of proteins located within the pre- and postsynaptic elements of inhibitory synapses. To this end, we exploited molecular markers of inhibitory synapses, interneurons and dystrophin-deficient mouse models to explore the role of dystrophin in determining the stereotypical patterning of inhibitory connectivity within the cellular networks of the hippocampus CA1 region. In tissue from wild-type (WT mice, immunoreactivity of neuroligin2 (NL2, an adhesion molecule expressed exclusively in postsynaptic elements of inhibitory synapses, and the vesicular GABA transporter (VGAT, a marker of GABAergic presynaptic elements, were predictably enriched in strata pyramidale and lacunosum moleculare. In acute contrast, NL2 and VGAT immunoreactivity was relatively evenly distributed across all CA1 layers in dystrophin-deficient mice. Similar changes were evident with the cannabinoid receptor 1, vesicular glutamate transporter 3, parvalbumin, somatostatin and the GABAA receptor alpha1 subunit. The data show that in the absence of dystrophin, there is a rearrangement of the molecular machinery, which underlies the precise spatio-temporal pattern of GABAergic synaptic transmission within the CA1 sub-field of the hippocampus.

  13. Black bear parathyroid hormone has greater anabolic effects on trabecular bone in dystrophin-deficient mice than in wild type mice.

    Science.gov (United States)

    Gray, Sarah K; McGee-Lawrence, Meghan E; Sanders, Jennifer L; Condon, Keith W; Tsai, Chung-Jui; Donahue, Seth W

    2012-09-01

    Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease that has deleterious consequences in muscle and bone, leading to decreased mobility, progressive osteoporosis, and premature death. Patients with DMD experience a higher-than-average fracture rate, particularly in the proximal and distal femur and proximal tibia. The dystrophin-deficient mdx mouse is a model of DMD that demonstrates muscle degeneration and fibrosis and osteoporosis. Parathyroid hormone, an effective anabolic agent for post-menopausal and glucocorticoid-induced osteoporosis, has not been explored for DMD. Black bear parathyroid hormone (bbPTH) has been implicated in the maintenance of bone properties during extended periods of disuse (hibernation). We cloned bbPTH and found 9 amino acid residue differences from human PTH. Apoptosis was mitigated and cAMP was activated by bbPTH in osteoblast cultures. We administered 28nmol/kg of bbPTH 1-84 to 4-week old male mdx and wild type mice via daily (5×/week) subcutaneous injection for 6 weeks. Vehicle-treated mdx mice had 44% lower trabecular bone volume fraction than wild type mice. No changes were found in femoral cortical bone geometry or mechanical properties with bbPTH treatment in wild type mice, and only medio-lateral moment of inertia changed with bbPTH treatment in mdx femurs. However, μCT analyses of the trabecular regions of the distal femur and proximal tibia showed marked increases in bone volume fraction with bbPTH treatment, with a greater anabolic response (7-fold increase) in mdx mice than wild type mice (2-fold increase). Trabecular number increased in mdx long bone, but not wild type bone. Additionally, greater osteoblast area and decreased osteoclast area were observed with bbPTH treatment in mdx mice. The heightened response to PTH in mdx bone compared to wild type suggests a link between dystrophin deficiency, altered calcium signaling, and bone. These findings support further investigation of PTH as an anabolic

  14. Quantification of the mechanical behavior of carotid arteries from wild-type, dystrophin-deficient, and sarcoglycan-δ knockout mice

    Science.gov (United States)

    Gleason, Rudolph L.; Dye, Wendy W.; Wilson, Emily; Humphrey, Jay D.

    2008-01-01

    As patients with muscular dystrophy live longer because of improved clinical care, they will become increasingly susceptible to many of the cardiovascular diseases that affect the general population. There is, therefore, a pressing need to better understand both the biology and the mechanics of the arterial wall in these patients. In this paper, we use nonlinear constitutive relations to model, for the first time, the biaxial mechanical behavior of carotid arteries from two common mouse models of muscular dystrophy (dystrophin deficient and sarcoglycan-delta null) and wild-type controls. It is shown that a structurally motivated four-fiber family stress-strain relation describes the passive behavior of all three genotypes better than does a commonly used phenomenological exponential model, and that a Rachev-Hayashi model describes the mechanical contribution of smooth muscle contraction under basal tone. Because structurally motivated constitutive relations can be extended easily to model adaptations to altered hemodynamics, results from this study represent an important step toward the ultimate goal of understanding better the mechanobiology and pathophysiology of arteries in muscular dystrophy. PMID:18842267

  15. Deletion of Galgt2 (B4Galnt2) Reduces Muscle Growth in Response to Acute Injury and Increases Muscle Inflammation and Pathology in Dystrophin-Deficient Mice

    Science.gov (United States)

    Xu, Rui; Singhal, Neha; Serinagaoglu, Yelda; Chandrasekharan, Kumaran; Joshi, Mandar; Bauer, John A.; Janssen, Paulus M.L.; Martin, Paul T.

    2016-01-01

    Transgenic overexpression of Galgt2 (official name B4Galnt2) in skeletal muscle stimulates the glycosylation of α dystroglycan (αDG) and the up-regulation of laminin α2 and dystrophin surrogates known to inhibit muscle pathology in mouse models of congenital muscular dystrophy 1A and Duchenne muscular dystrophy. Skeletal muscle Galgt2 gene expression is also normally increased in the mdx mouse model of Duchenne muscular dystrophy compared with the wild-type mice. To assess whether this increased endogenous Galgt2 expression could affect disease, we quantified muscular dystrophy measures in mdx mice deleted for Galgt2 (Galgt2−/−mdx). Galgt2−/− mdx mice had increased heart and skeletal muscle pathology and inflammation, and also worsened cardiac function, relative to age-matched mdx mice. Deletion of Galgt2 in wild-type mice also slowed skeletal muscle growth in response to acute muscle injury. In each instance where Galgt2 expression was elevated (developing muscle, regenerating muscle, and dystrophic muscle), Galgt2-dependent glycosylation of αDG was also increased. Overexpression of Galgt2 failed to inhibit skeletal muscle pathology in dystroglycan-deficient muscles, in contrast to previous studies in dystrophin-deficient mdx muscles. This study demonstrates that Galgt2 gene expression and glycosylation of αDG are dynamically regulated in muscle and that endogenous Galgt2 gene expression can ameliorate the extent of muscle pathology, inflammation, and dysfunction in mdx mice. PMID:26435413

  16. Low-Level Laser Therapy (LLLT) in Dystrophin-Deficient Muscle Cells: Effects on Regeneration Capacity, Inflammation Response and Oxidative Stress.

    Science.gov (United States)

    Macedo, Aline Barbosa; Moraes, Luis Henrique Rapucci; Mizobuti, Daniela Sayuri; Fogaça, Aline Reis; Moraes, Fernanda Dos Santos Rapucci; Hermes, Tulio de Almeida; Pertille, Adriana; Minatel, Elaine

    2015-01-01

    The present study evaluated low-level laser therapy (LLLT) effects on some physiological pathways that may lead to muscle damage or regeneration capacity in dystrophin-deficient muscle cells of mdx mice, the experimental model of Duchenne muscular dystrophy (DMD). Primary cultures of mdx skeletal muscle cells were irradiated only one time with laser and analyzed after 24 and 48 hours. The LLLT parameter used was 830 nm wavelengths at 5 J/cm² fluence. The following groups were set up: Ctrl (untreated C57BL/10 primary muscle cells), mdx (untreated mdx primary muscle cells), mdx LA 24 (mdx primary muscle cells - LLLT irradiated and analyzed after 24 h), and mdx LA 48 (mdx primary muscle cells - LLLT irradiated and analyzed after 48 h). The mdx LA 24 and mdx LA 48 groups showed significant increase in cell proliferation, higher diameter in muscle cells and decreased MyoD levels compared to the mdx group. The mdx LA 48 group showed significant increase in Myosin Heavy Chain levels compared to the untreated mdx and mdx LA 24 groups. The mdx LA 24 and mdx LA 48 groups showed significant increase in [Ca2+]i. The mdx group showed significant increase in H2O2 production and 4-HNE levels compared to the Ctrl group and LLLT treatment reduced this increase. GSH levels and GPx, GR and SOD activities increased in the mdx group. Laser treatment reduced the GSH levels and GR and SOD activities in dystrophic muscle cells. The mdx group showed significant increase in the TNF-α and NF-κB levels, which in turn was reduced by the LLLT treatment. Together, these results suggest that the laser treatment improved regenerative capacity and decreased inflammatory response and oxidative stress in dystrophic muscle cells, indicating that LLLT could be a helpful alternative therapy to be associated with other treatment for dystrophinopathies.

  17. Low-Level Laser Therapy (LLLT in Dystrophin-Deficient Muscle Cells: Effects on Regeneration Capacity, Inflammation Response and Oxidative Stress.

    Directory of Open Access Journals (Sweden)

    Aline Barbosa Macedo

    Full Text Available The present study evaluated low-level laser therapy (LLLT effects on some physiological pathways that may lead to muscle damage or regeneration capacity in dystrophin-deficient muscle cells of mdx mice, the experimental model of Duchenne muscular dystrophy (DMD. Primary cultures of mdx skeletal muscle cells were irradiated only one time with laser and analyzed after 24 and 48 hours. The LLLT parameter used was 830 nm wavelengths at 5 J/cm² fluence. The following groups were set up: Ctrl (untreated C57BL/10 primary muscle cells, mdx (untreated mdx primary muscle cells, mdx LA 24 (mdx primary muscle cells - LLLT irradiated and analyzed after 24 h, and mdx LA 48 (mdx primary muscle cells - LLLT irradiated and analyzed after 48 h. The mdx LA 24 and mdx LA 48 groups showed significant increase in cell proliferation, higher diameter in muscle cells and decreased MyoD levels compared to the mdx group. The mdx LA 48 group showed significant increase in Myosin Heavy Chain levels compared to the untreated mdx and mdx LA 24 groups. The mdx LA 24 and mdx LA 48 groups showed significant increase in [Ca2+]i. The mdx group showed significant increase in H2O2 production and 4-HNE levels compared to the Ctrl group and LLLT treatment reduced this increase. GSH levels and GPx, GR and SOD activities increased in the mdx group. Laser treatment reduced the GSH levels and GR and SOD activities in dystrophic muscle cells. The mdx group showed significant increase in the TNF-α and NF-κB levels, which in turn was reduced by the LLLT treatment. Together, these results suggest that the laser treatment improved regenerative capacity and decreased inflammatory response and oxidative stress in dystrophic muscle cells, indicating that LLLT could be a helpful alternative therapy to be associated with other treatment for dystrophinopathies.

  18. Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy

    Directory of Open Access Journals (Sweden)

    Guttridge Denis C

    2011-05-01

    Full Text Available Abstract Background Duchenne muscular dystrophy (DMD is an inherited and progressive disease causing striated muscle deterioration. Patients in their twenties generally die from either respiratory or cardiac failure. In order to improve the lifespan and quality of life of DMD patients, it is important to prevent or reverse the progressive loss of contractile function of the heart. Recent studies by our labs have shown that the peptide NBD (Nemo Binding Domain, targeted at blunting Nuclear Factor κB (NF-κB signaling, reduces inflammation, enhances myofiber regeneration, and improves contractile deficits in the diaphragm in dystrophin-deficient mdx mice. Methods To assess whether cardiac function in addition to diaphragm function can be improved, we investigated physiological and histological parameters of cardiac muscle in mice deficient for both dystrophin and its homolog utrophin (double knockout = dko mice treated with NBD peptide. These dko mice show classic pathophysiological hallmarks of heart failure, including myocyte degeneration, an impaired force-frequency response and a severely blunted β-adrenergic response. Cardiac contractile function at baseline and frequencies and pre-loads throughout the in vivo range as well as β-adrenergic reserve was measured in isolated cardiac muscle preparations. In addition, we studied histopathological and inflammatory markers in these mice. Results At baseline conditions, active force development in cardiac muscles from NBD treated dko mice was more than double that of vehicle-treated dko mice. NBD treatment also significantly improved frequency-dependent behavior of the muscles. The increase in force in NBD-treated dko muscles to β-adrenergic stimulation was robustly restored compared to vehicle-treated mice. However, histological features, including collagen content and inflammatory markers were not significantly different between NBD-treated and vehicle-treated dko mice. Conclusions We conclude

  19. A comparative study of N-glycolylneuraminic acid (Neu5Gc and cytotoxic T cell (CT carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle.

    Directory of Open Access Journals (Sweden)

    Paul T Martin

    Full Text Available The expression of N-glycolylneuraminic acid (Neu5Gc and the cytotoxic T cell (CT carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice. Here, we describe the expression of these two glycans in skeletal muscles of dogs and humans with or without dystrophin-deficiency. Neu5Gc expression was highly reduced (>95% in muscle from normal golden retriever crosses (GR, n = 3 and from golden retriever with muscular dystrophy (GRMD, n = 5 dogs at multiple ages (3, 6 and 13 months when compared to mouse muscle, however, overall sialic acid expression in GR and GRMD muscles remained high at all ages. Neu5Gc was expressed on only a minority of GRMD satellite cells, CD8⁺ T lymphocytes and macrophages. Human muscle from normal (no evident disease, n = 3, Becker (BMD, n = 3 and Duchenne (DMD, n = 3 muscular dystrophy individuals had absent to very low Neu5Gc staining, but some punctate intracellular muscle staining was present in BMD and DMD muscles. The CT carbohydrate was localized to the neuromuscular junction in GR muscle, while GRMD muscles had increased expression on a subset of myofibers and macrophages. In humans, the CT carbohydrate was ectopically expressed on the sarcolemmal membrane of some BMD muscles, but not normal human or DMD muscles. These data are consistent with the notion that altered Neu5Gc and CT carbohydrate expression may modify disease severity resulting from dystrophin deficiency in dogs and humans.

  20. A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle.

    Science.gov (United States)

    Martin, Paul T; Golden, Bethannie; Okerblom, Jonathan; Camboni, Marybeth; Chandrasekharan, Kumaran; Xu, Rui; Varki, Ajit; Flanigan, Kevin M; Kornegay, Joe N

    2014-01-01

    The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice. Here, we describe the expression of these two glycans in skeletal muscles of dogs and humans with or without dystrophin-deficiency. Neu5Gc expression was highly reduced (>95%) in muscle from normal golden retriever crosses (GR, n = 3) and from golden retriever with muscular dystrophy (GRMD, n = 5) dogs at multiple ages (3, 6 and 13 months) when compared to mouse muscle, however, overall sialic acid expression in GR and GRMD muscles remained high at all ages. Neu5Gc was expressed on only a minority of GRMD satellite cells, CD8⁺ T lymphocytes and macrophages. Human muscle from normal (no evident disease, n = 3), Becker (BMD, n = 3) and Duchenne (DMD, n = 3) muscular dystrophy individuals had absent to very low Neu5Gc staining, but some punctate intracellular muscle staining was present in BMD and DMD muscles. The CT carbohydrate was localized to the neuromuscular junction in GR muscle, while GRMD muscles had increased expression on a subset of myofibers and macrophages. In humans, the CT carbohydrate was ectopically expressed on the sarcolemmal membrane of some BMD muscles, but not normal human or DMD muscles. These data are consistent with the notion that altered Neu5Gc and CT carbohydrate expression may modify disease severity resulting from dystrophin deficiency in dogs and humans.

  1. Environmental Assessment for Proposed Enlisted Dormitory, Cavalier Air Force Station, North Dakota

    Science.gov (United States)

    2011-07-01

    Cavalier AFS Final - July 2011 (Euphorbia esula), musk thistle (Carduus nutans), false chamomile (Matricaria perforate), and perennial sow thistle ...weeds that have been identified at Cavalier AFS are Canada thistle (Cirsium arvense), leafy spurge 3-14 EA for Proposed Enlisted Dormitory at...introduced in 1997 to prioritize the identification and assessment of environmental health and safety risks that may affect children and to ensure that

  2. Final Environmental Assessment for Construction and Operation of a Water Treatment Building at Cavalier Air Force Station, North Dakota

    Science.gov (United States)

    2010-07-01

    01.1). Noxious weeds that have been identified at Cavalier AFS are Canada thistle , leafy spurge, musk thistle , false chamomile, and perennial sow... thistle . The installation actively manages noxious weeds on site. Weed man- agement is conducted annually with primary emphasis during the spring and...infrastructure required for ongoing identification , management, tracking, and mini- mization of hazardous materials. Cavalier AFS has numerous plans

  3. Identification of 2 loci associated with development of myxomatous mitral valve disease in Cavalier King Charles Spaniels

    DEFF Research Database (Denmark)

    Madsen, Majbritt Busk; Olsen, Lisbeth Høier; Häggström, Jens;

    2011-01-01

    of MMVD as cases and old dogs with no or mild signs of MMVD as controls, we conducted a genome-wide association study (GWAS) to identify loci associated with development of MMVD. We have identified a 1.58 Mb region on CFA13 (P(genome) = 4.0 × 10(-5)) and a 1.68 Mb region on CFA14 (P(genome) = 7.9 × 10......(-4)) associated with development of MMVD. This confirms the power of using the dog as a model to uncover potential candidate regions involved in the molecular mechanisms behind complex traits....

  4. Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease

    DEFF Research Database (Denmark)

    Moesgaard, Sophia Gry; Løwert, Charlotte Klostergaard; Zois, Nora Elisabeth

    2012-01-01

    Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction.......Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction....

  5. Advanced electrocardiographic parameters change with severity of mitral regurgitation in Cavalier King Charles Spaniels in sinus rhythm

    DEFF Research Database (Denmark)

    Pakkanen, M. Spiljak; Petric, A. Domanjko; Olsen, Lisbeth Høier;

    2012-01-01

    Multiple advanced resting ECG (A-ECG) techniques have improved the diagnostic or prognostic value of ECG in detecting human cardiac diseases even before onset of clinical signs or changes in conventional ECG.......Multiple advanced resting ECG (A-ECG) techniques have improved the diagnostic or prognostic value of ECG in detecting human cardiac diseases even before onset of clinical signs or changes in conventional ECG....

  6. Guillem IV de Cervera, cavalier i monjo de Poblet

    Directory of Open Access Journals (Sweden)

    Gonzalvo i Bou, Gener

    1998-12-01

    Full Text Available Guillem IV of Cervera could be the prototype of the noble closely linked to all spheres of power. This article studies his connections as a councillor to the royal court of Pere I and during the early decades of that of Jaume I, at a time of crisis for this royal institution. Guillem of Cervera was also a key player in the difficult relations between the crown and the earldom of Urgell in the context of the absortion of the earldom into the House of Barcelona. On a spiritual level, the close ties between a lineage like the House of Cervera and the monastery of Poblet will be shown, these perhaps being in the image and reflections of the kings.[fr] Guillem IV de Cervera pourrait être le prototype de chevalier lié étroitement à toutes les spheres du pouvoir. Dans cet article, nous étudions ses relations en tant que conseiller de la cour royale de Pere I et ses relations dans la première époque du règne de Jaume I, à une époque de crise de l'institution royale. Guillem de Cervera fut aussi un personnage clé dans les rapports difficiles entre la Couronne et le Comté d'Urgell, dans un contexte d'absorption du Comté à la Maison de Barcelone. Au niveau spirituel, nous montrons les liens étroits d'une lignée comme celle des Cervera avec le monastère de Poblet, à l'image de ses rois.

  7. Kings Today, Rich Tomorrow

    DEFF Research Database (Denmark)

    Fattoum, Asma

    2013-01-01

    This study investigates the King vs. Rich dilemma that founder-CEOs face at IPO. When undertaking IPO, founders face two options. They can either get rich, but then run the risk of losing the control over their firms; or they can remain kings by introducing defensive mechanisms, but this is likely...... to lead to lower IPO valuation. Using psychological ownership theory, we argue founder-CEOs to be more likely to choose the King option. This option forces them to leave money on the table at the IPO. However, their stewardship behavior allows them to recover that money on the long-run post IPO. We...... provide support for all hypotheses using a unique hand-collected dataset covering the full population of 467 IPOs undertaken in France between 1992 and 2011....

  8. Of Gods and Kings

    DEFF Research Database (Denmark)

    Brisch, Nicole

    2013-01-01

    throughout history. This is not a new point but remains all too often underappreciated when discussing the blurring of lines between human and god as evidenced in the deification of kings. In ancient Mesopotamia, one of the oldest high civilizations in the world, it was a short-lived but nevertheless...... interesting phenomenon. The first instances of royal deification occur in the third millennium BCE during times of political expansion and centralization. Whether this worship continued into the second millennium BCE is still a matter of contention, yet Mesopotamian kings always maintained a close proximity...

  9. Forty Four Years a King.

    Science.gov (United States)

    Minneapolis Public Schools, Minn. Dept. of Intergroup Education.

    This curriculum unit contains guidelines for Martin Luther King Jr. Day, January 15th. Items included in the guide are: a list of suggested activities, a short biography of Dr. King, excerpts from some of his speeches including the famous, "I Have A Dream" speech, a play, study questions, "A King's Journey", a game, and a story…

  10. Dr. King's Dream. [Lesson Plan].

    Science.gov (United States)

    National Endowment for the Humanities (NFAH), Washington, DC.

    This lesson plan teaches students about the life and work of Martin Luther King, Jr. Students listen to a brief biography, view photographs of the March on Washington, hear a portion of King's "I Have a Dream" speech, and discuss what King's words mean to them. Finally, they will create picture books about their own dreams of freedom for…

  11. Of Gods and Kings

    DEFF Research Database (Denmark)

    Brisch, Nicole

    2013-01-01

    throughout history. This is not a new point but remains all too often underappreciated when discussing the blurring of lines between human and god as evidenced in the deification of kings. In ancient Mesopotamia, one of the oldest high civilizations in the world, it was a short-lived but nevertheless...

  12. The Lion King

    Institute of Scientific and Technical Information of China (English)

    齐玉俊; 温静

    2005-01-01

    Cultural Background of the Film The Lion King, released by Walt Disney Picture in 1994, was one of the top blockbusters in the past ten yesars in the US. There are at least two reasons for its popularity. One is the charm of Shakespeare's theme: Hamlet, and the other is the attraction of African scencry.

  13. Dystrophin deficiency-induced changes in porcine skeletal muscle

    Science.gov (United States)

    A novel porcine stress syndrome was detected in the U.S. Meat Animal Research Center’s swine research population when two sibling barrows died of apparent stress symptoms (open mouth breathing, vocalization, and refusal to move or stand) after transport at 12 weeks of age. At eight weeks of age, the...

  14. Gait analysis using accelerometry in dystrophin-deficient dogs.

    Science.gov (United States)

    Barthélémy, Inès; Barrey, Eric; Thibaud, Jean-Laurent; Uriarte, Ane; Voit, Thomas; Blot, Stéphane; Hogrel, Jean-Yves

    2009-11-01

    Dogs affected with Golden Retriever Muscular Dystrophy (GRMD) exhibit striking clinical similarities with patients suffering from Duchenne muscular dystrophy (DMD), particularly gait impairments. The purpose of this study was to describe the use and reliability of accelerometry in gait assessment of dogs with muscular dystrophy. Eight healthy and 11 GRMD adult dogs underwent three gait assessment sessions, using accelerometry. Three-axial recordings of accelerations were performed, and gait variables calculated. Total power, force and regularity of accelerations, stride length and speed, normalized by height at withers, stride frequency, and cranio-caudal power were significantly decreased, whereas medio-lateral power was significantly increased in GRMD dogs. Moreover, these variables were repeatable within and between sessions. Accelerometry provides reliable variables which highlight specific gait patterns of GRMD dogs, describing objectively and quantitatively their slow, short-stepped, and swaying gait. As it is easy to set-up, quick to perform and inexpensive, accelerometry represents a useful tool, to assess locomotion during pre-clinical trials.

  15. Martin Luther King Day

    Institute of Scientific and Technical Information of China (English)

    邵有为

    2005-01-01

    @@ It was December, 1955, and Martin Luther King, Jr. had just received his doctorate3 degree in theology4. He had moved to Montgomery, Alabama to preach5 at a Baptist church. He saw there, as in many other southern states, that African-Americans had to ride in the back of public buses. Dr. King knew that this law violated6 the rights of every African-American. He organized and led a boycott7 of the public buses in the city of Montgomery. Any person, black or white, who was against segregation8 refused to use public transportation. Those people who boycotted were threatened or attacked by other people, or even arrested or jailed by the police. After one year of boycotting the bus system, the Supreme Court9declared that the Alabama state segregation law was unconstitutional10.

  16. King Gesar Effectively Saved

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    King Gesar is an encyclopedia with contents covering social develop-ment, history, wars, religious belief, folklore, linguistics and exchanges between different tribes.In Tibet, folk balladeers declare they can sing up to 1,000 volumes of the epic, passed down through history orally and enriched in contents by the public themselves. The Central Government sets great store by the gathering, compiling and publishing of the epic, considered to be longer

  17. When physics became king

    CERN Document Server

    Morus, Iwan Rhys

    2005-01-01

    As recently as two hundred years ago, physics as we know it today did not exist. Born in the early nineteenth century during the second scientific revolution, physics struggled at first to achieve legitimacy in the scientific community and culture at large. In fact, the term "physicist" did not appear in English until the 1830s.When Physics Became King traces the emergence of this revolutionary science, demonstrating how a discipline that barely existed in 1800 came to be regarded a century later as the ultimate key to unlocking nature's secrets. A cultural history designed to provid

  18. King Tide floods in Tuvalu

    Science.gov (United States)

    Lin, C.-C.; Ho, C.-R.; Cheng, Y.-H.

    2013-05-01

    The spatial and temporal distributions of sea level rise present regional floods in some certain areas. The low-lying island countries are obviously the spots affected severely. Tuvalu, an atoll island country located in the south-west Pacific Ocean, is suffering the devastating effects of losing life, property, and intending migration caused by floods. They blame the regional flooding to King Tide, a term used but not clearly identified by Pacific islanders. In this study, we clarify what King Tide is first. By the tide gauge and topography data, we estimated the reasonable value of 3.2 m as the threshold of King Tide. This definition also fits to the statement by National Oceanic and Atmospheric Administration (NOAA) of King Tide occurring once or twice a year. In addition, We cross validate the 19 yr data of tide gauge and satellite altimeter (1993-2012), the correlation coefficient indicates King Tide phenomenon is considerable connected to warm water mass. The 28 King Tide events revealed the fact that flooding can be referenced against spring tide levels, so can it be turned up by warm water mass. The warm water mass pushes up sea level; once spring tide, storm surge, or other climate variability overlaps it, the rising sea level might overflow and so has been called "King Tide" for the floods in Tuvalu. This study provides more understanding of the signals of King Tide and an island country case study of regional sea level rise.

  19. The fermionic King model

    CERN Document Server

    Chavanis, Pierre-Henri; Méhats, Florian

    2014-01-01

    We study the fermionic King model which may provide a relevant model of dark matter halos. The exclusion constraint can be due to quantum mechanics (for fermions such as massive neutrinos) or to Lynden-Bell's statistics (for collisionless systems undergoing violent relaxation). This model has a finite mass. Furthermore, a statistical equilibrium state exists for all accessible values of energy. Dwarf and intermediate size halos are degenerate quantum objects stabilized against gravitational collapse by the Pauli exclusion principle. Large halos at sufficiently high energies are in a gaseous phase where quantum effects are negligible. They are stabilized by thermal motion. Below a critical energy they undergo gravitational collapse (gravothermal catastrophe). This may lead to the formation of a central black hole that does not affect the structure of the halo. This may also lead to the formation of a compact degenerate object surrounded by a hot massive atmosphere extending at large distances. We argue that la...

  20. The last Viking King

    DEFF Research Database (Denmark)

    Dissing, J.; Binladen, J.; Hansen, Anders J.

    2007-01-01

    of King Sven Estridsen to haplogroup H; Estrid's sequence differed from that of Sven at two positions in HVR-1, 16093T -> C and 16304T -> C, indicating that she belongs to subgroup H5a. Given the maternal inheritance of mtDNA, offspring will have the same mtDNA sequence as their mother with the exception...... was much younger (approximately 35 years) at the time of death than the 70 years history records tell. Although the entombed woman cannot be the Estrid, she may well be one of Sven's two daughters-in-law who were also called Estrid and who both became queens. (c) 2006 Elsevier Ireland Ltd. All rights...

  1. The King Tapestries at Kronborg Castle

    DEFF Research Database (Denmark)

    Reindel, Ulrik

    2015-01-01

    In the 1580s, Frederik II (Danish-Norwegian king, reigned 1559-1588) had the Great Hall at Kronborg Castle, Elsinore, furnished with 43 tapestries portraying no fewer than 100 Danish kings. The tapestries were arranged chronologically, beginning with King Dan, the mythological founder of the king......In the 1580s, Frederik II (Danish-Norwegian king, reigned 1559-1588) had the Great Hall at Kronborg Castle, Elsinore, furnished with 43 tapestries portraying no fewer than 100 Danish kings. The tapestries were arranged chronologically, beginning with King Dan, the mythological founder...

  2. Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates

    DEFF Research Database (Denmark)

    Thøfner, Maria Søndergaard; Stougaard, C. L.; Westrup, Ulrik

    2015-01-01

    (P euthanasia in 20%. Dogs with syringes, which expressed no clinical signs at the age of 6, remained asymptomatic in 14/15 cases (93%). CONCLUSIONS AND CLINICAL IMPORTANCE: The prevalence of symptomatic SM is high...

  3. Breeding Restrictions Decrease the Prevalence of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels over an 8-to 10-Year Period

    DEFF Research Database (Denmark)

    Birkegård, Anna Camilla; Reimann, M. J.; Martinussen, T.;

    2016-01-01

    compared with dogs in 2002-2003, reflecting a 73% decreased risk (P Importance: A mandatory breeding scheme based on auscultation...... and echocardiography findings significantly decreased the prevalence of MMVD over the 8- to 10-year period. Such a breeding scheme therefore is recommended for CKCS....

  4. Congratulations to Carey King

    Science.gov (United States)

    Hall, Charles A. S.

    2012-03-01

    I first came across Carey King when, out of the blue, he invited me to a special session of the annual meeting of the American Association for the Advancement of Science (the largest and most prestigious US scientific meeting) where he was developing a special session on energy return on investment (EROI). At that meeting and since, I have found Carey to be a refreshing new colleague, extremely intelligent, very knowledgeable about many diverse aspects of energy and other things, able to take criticism and to dish it out, and very ambitious, which is mostly a good thing. He is becoming a leader in thinking about EROI and its implications, and I am delighted to see him honored by Environmental Research Letters. This is important because in the US, there is little insight about energy or, especially, its potential physical limitations except when gas prices increase. There is also little awareness of the very strong historical connection in both the US and the world between increased affluence and increased use of energy, especially petroleum. It is not understood by all that many of the economic problems we have now (such as the budgetary problems faced by most of our State governments, pension plans and universities) have substantial origin in the fact that oil and other energy production no longer increase reliably year after year, as they once did (Murphy and Hall 2011). Many economists have argued in the past that energy is not important because it constituted only 5 per cent or so of GDP, or because they believe that market forces and innovations will substitute for any shortage (e.g. Barnett and Morse 1963, Passell et al 1972, Solow 1974, Denison 1989). One problem with that view is that if you remove that five per cent the economy comes to a dead stop, as Cuba found out in 1989 when Russia removed its oil subsidy. Additionally if that five per cent goes up to 10 or 15 per cent, as it did in the early 1980s, and again in 2008, recession steps in (Murphy and

  5. Martin Luther King, Jr. Teacher's Resource Manual.

    Science.gov (United States)

    Connecticut State Dept. of Education, Hartford.

    This Connecticut teachers' manual on Martin Luther King, Jr. includes: (1) teacher background information; (2) five excerpts from King's speeches; (3) four themes for lesson plans; and (4) sample lesson plans. The teacher's background information provides biographical sketches of King and his precursors. The five speeches reproduced here are…

  6. Views of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Davis, Alan H.

    1990-01-01

    Discusses views of Martin Luther King, Jr., including concepts of human rights, related counseling approaches, and ethics. Claims King's views provide helpful insights for counselors and clients. Concludes King invited individuals to view challenging life situations as moral opportunities. (Author/ABL)

  7. Books about Martin Luther King, Jr.

    Science.gov (United States)

    Woll, Christina B.

    1990-01-01

    Briefly reviews three recent biographies of Martin Luther King, Jr. that also deal with the civil rights movement. Summarizes contents and identifies reading ability levels appropriate for elementary and junior high students. Recommends six additional King biographies for children. Also endorses two filmstrips on King and the movement. Gives full…

  8. "Shiva Natavaja, King of Dancers."

    Science.gov (United States)

    Prabhu, Vas

    1987-01-01

    Offers an art lesson designed to introduce junior high school students to a Shiva sculpture and to Hindu symbolism. The lesson is based on a full-color photograph of a 500 year-old bronze sculpture entitled Shiva Nataraja, King of Dancers. (BR)

  9. The philosophical core of King's conceptual system.

    Science.gov (United States)

    Whelton, B J

    1999-04-01

    Aristotelian understanding of being human is presented as the philosophical core of King's conceptual system. A summary of King's thought is organized according to contemporary influences. The article then turns to what Aristotle teaches about the composition of the world and what it means to be a human being. Wallace's life-powers model of the soul brings these insights into contemporary thought. Aristotelian philosophy completes King's account of the personal system by providing insight into what it is to be human. Parallels in the reasoning of transaction and Aristotelian deliberation are further evidence of classical influences within King's work.

  10. The Words of Martin Luther King, Jr.

    Science.gov (United States)

    Today's Education, 1979

    1979-01-01

    Excerpts from speeches by Dr. Martin Luther King, Jr., are reprinted. Topics discussed include discrimination, the South, education, nonviolent resistance, poverty, economic opportunity, and world peace. (LH)

  11. The True Lion King of Africa: The Epic History of Sundiata, King of Old Mali.

    Science.gov (United States)

    Paterno, Domenica R.

    David Wisniewski's 1992 picture book version of the African epic of "Sundiata, Lion King of Mali" and the actual historical account of the 13th century Lion King, Sundiata, are both badly served by Disney's "The Lion King." Disney has been praised for using African animals as story characters; for using the African landscape as…

  12. King in a maverick style.

    Science.gov (United States)

    Abbasi, K

    1999-10-09

    This article features Maurice King, who is advocating a one-child world. King was born in 1927 in Ceylon (now Sri Lanka) and studied at Trinity Hall, Cambridge, and St. Thomas Hospital, London. He first worked as a pathologist, moving to Africa in 1956. He was always willing to fight injustice, objecting to not being allowed to train black Africans. He authored ¿Medical Care in Developing Countries,¿ considered the ¿Bible¿ of the primary health care movement. By 1985, he was teaching public health medicine at Leeds University, having spent most of his time in Africa working on various projects for the WHO, and was focusing on primary health care. His other great cause then was nuclear disarmament. His lecture to the Royal Society of Medicine on health of Africa in 1988 ignited his interest in demography. He had then championed ideas, which initially provoked outrage, such as the case with ¿entrapment,¿ the hardinian taboo, and now his concept of the lockstep. He had claimed that the US State Department, together with UN, the World Bank and the Roman Catholic Church, is actively preventing population issues being discussed fully. He may appear on the surface as obsessed with imposing a one-child world and paranoid about the role of the US; but a closer analysis reveals a deep affection for Africa and a missionary zeal to surmount the problems of overpopulation.

  13. The King's Ring: A Matter of Trust

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2017-01-01

    This essay examines the material and social effects of an exchange of trust between a king, Henry VIII, and his counsellor, Thomas Cranmer in Shakespeare and Fletcher’s All is True. The ring that the King gives Cranmer is both nothing and everything: nothing in that it could be anything, any ring...

  14. Yolanda King to deliver keynote address for Martin Luther King celebration

    OpenAIRE

    Lazenby, Jenna

    2007-01-01

    Yolanda King, the eldest of Dr. Martin Luther King Jr.'s children, and founder and CEO of Higher Ground Productions, an organization dedicated to teach people to celebrate diversity and embrace unity, will speak in Burruss Hall Auditorium at 7 p.m., on Monday, Jan. 15 to kick-off the week-long celebration of Dr. Martin Luther King's legacy. Tickets are free for the general public.

  15. John Davies of Hereford, the King of Denmark & Shakespeare's Meeting of Kings: Praise Beyond Praise

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2016-01-01

    This article traces the response and style of John Davies of Hereford, 'an ordinary man' as he celebrated an extraordinary event, the state visit of the King of Denmark to the court of James I in 1606. It then draws comparisons to Shakespeare's meeting of kings some seven or eight years later...

  16. Kinging in the heartland; or, the power of marginality.

    Science.gov (United States)

    Piontek, Thomas

    2002-01-01

    Theorizations of the drag king phenomenon and definitions of "the Drag King" thus far have relied almost exclusively on Judith Halberstam's description of the drag king scenes in New York, London, and San Francisco. In order to expand the scope of the investigation of drag king culture and as an example of the range of drag kings and drag king acts that have developed across the U.S. and across the world, this article focuses on H.I.S. Kings, a group of women, who have been performing in Columbus, Ohio since 1996. By infusing drag with a dose of theory, which is always tempered by their outrageous sense of humor, H.I.S. Kings have developed what arguably is one of the most interesting varieties of kinging, an approach to the genre of the drag show that Halberstam's model cannot account for. Unlike kings in New York, for example, H.I.S. Kings frequently utilize the supposedly gay male form of camp in their performance of multiple masculinities and femininities, and they create innovative ensemble numbers that engage the racial and gender politics of drag. The example of H.I.S. Kings calls into question any theorization of the drag king phenomenon that ignores cultural developments in the heartland by focusing exclusively on cities traditionally considered the centers of queer culture.

  17. EDITORIAL: King of the elements? King of the elements?

    Science.gov (United States)

    Demming, Anna

    2010-07-01

    Throughout the history of science, carbon-based research has played a defining role in the development of a range of fundamental and technological fields. It was used in Avagadro's definition of the mole in the early 18th century, it provides the 'backbone' of molecules in organic compounds, and in the environmental debate currently raging in the press and international government discussions, the 'carbon footprint' has become the metric of our species' impact on our planet. Also in nanotechnology, with the discovery of various wonder materials, carbon is once again asserting its claim as king of the elements. Until the 1980s the only known forms of carbon were diamond, graphite and amorphous carbon, as in soot or charcoal. In 1985 Robert Curl, Harold Kroto and Richard Smalley reported the existence of fullerenes, spherical structures comprising hexagonal carbon rings [1], work for which they won the Nobel Prize for Chemistry in 1996 [2]. The discovery of fullerenes was followed in 1991 by Sumio Ijima with the discovery of rolled graphite sheets, the carbon nanotube [3]. The discovery of these novel carbon nanostructures inspired researchers in a range of fields, largely as a result of the extraordinary capacity for investigations of these structures to reveal ever more intriguing properties. One of the fascinating properties attributed to carbon nanotubes is their phenomenal strength, with a Young's modulus of single walled carbon nanotubes approaching a terapascal [4]. Ingenious methods of harnessing this strength have since been developed, including bucky paper, a term used to refer to a mat of randomly self-entangled carbon nanotubes. Steven Crannford and Markus Buehler have recently reported a novel computational technique for probing the mechanical properties of these structures and show that the Young's modulus of bucky paper can be tuned by manipulation of the carbon nanotube type and density [5]. The electrical properties of carbon nanotubes, which depend

  18. The Martin Luther King Library and Archives at the Crossroads.

    Science.gov (United States)

    Chepesiuk, Ron; Kelley-Palmer, Gloria

    1994-01-01

    Describes the collection of the Martin Luther King Library and Archives and examines recent problems that have developed. Topics discussed include a lack of adequate funding and personnel; the lawsuit concerning papers given to Boston University by Dr. King; and an interview with Coretta Scott King. (LRW)

  19. The Newest Monument: The Martin Luther King, Jr. National Memorial

    Science.gov (United States)

    Social Studies and the Young Learner, 2011

    2011-01-01

    This article features the newest monument, the Martin Luther King, Jr. National Memorial. The memorial on the National Mall in Washington, D.C., honoring Dr. Martin Luther King, Jr. will be an engaging landscape experience to convey four fundamental and recurring themes throughout Dr. King's life--democracy, justice, hope, and love. Natural…

  20. Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice

    OpenAIRE

    2009-01-01

    Editors' Summary Background Muscular dystrophies are genetic (inherited) diseases in which the body's muscles gradually weaken and degenerate. The commonest and most severe muscular dystrophy—Duchenne muscular dystrophy—affects 1 in 3,500 boys (girls can be carriers of the disease but rarely have any symptoms). At birth, these boys seem normal but the symptoms of their disease begin to appear in early childhood. Affected children may initially have difficulty walking or find it to hard to sit...

  1. Dystrophin deficiency leads to disturbance of LAMP1-vesicle-associated protein secretion

    DEFF Research Database (Denmark)

    Duguez, S.; Duddy, W.; Johnston, H.

    2013-01-01

    Duchenne muscular dystrophy results from loss of the protein dystrophin, which links the intracellular cytoskeletal network with the extracellular matrix, but deficiency in this function does not fully explain the onset or progression of the disease. While some intracellular events involved...... of new potential therapeutic targets....

  2. Disruption of action potential and calcium signaling properties in malformed myofibers from dystrophin-deficient mice.

    Science.gov (United States)

    Hernández-Ochoa, Erick O; Pratt, Stephen J P; Garcia-Pelagio, Karla P; Schneider, Martin F; Lovering, Richard M

    2015-04-01

    Duchenne muscular dystrophy (DMD), the most common and severe muscular dystrophy, is caused by the absence of dystrophin. Muscle weakness and fragility (i.e., increased susceptibility to damage) are presumably due to structural instability of the myofiber cytoskeleton, but recent studies suggest that the increased presence of malformed/branched myofibers in dystrophic muscle may also play a role. We have previously studied myofiber morphology in healthy wild-type (WT) and dystrophic (MDX) skeletal muscle. Here, we examined myofiber excitability using high-speed confocal microscopy and the voltage-sensitive indicator di-8-butyl-amino-naphthyl-ethylene-pyridinium-propyl-sulfonate (di-8-ANEPPS) to assess the action potential (AP) properties. We also examined AP-induced Ca(2+) transients using high-speed confocal microscopy with rhod-2, and assessed sarcolemma fragility using elastimetry. AP recordings showed an increased width and time to peak in malformed MDX myofibers compared to normal myofibers from both WT and MDX, but no significant change in AP amplitude. Malformed MDX myofibers also exhibited reduced AP-induced Ca(2+) transients, with a further Ca(2+) transient reduction in the branches of malformed MDX myofibers. Mechanical studies indicated an increased sarcolemma deformability and instability in malformed MDX myofibers. The data suggest that malformed myofibers are functionally different from myofibers with normal morphology. The differences seen in AP properties and Ca(2+) signals suggest changes in excitability and remodeling of the global Ca(2+) signal, both of which could underlie reported weakness in dystrophic muscle. The biomechanical changes in the sarcolemma support the notion that malformed myofibers are more susceptible to damage. The high prevalence of malformed myofibers in dystrophic muscle may contribute to the progressive strength loss and fragility seen in dystrophic muscles. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

  3. Effect of Dystrophin Deficiency on Selected Intrinsic Laryngeal Muscles of the "mdx" Mouse

    Science.gov (United States)

    Fry, Lisa T.; Stemple, Joseph C.; Andreatta, Richard D.; Harrison, Anne L.; Andrade, Francisco H.

    2010-01-01

    Background: Intrinsic laryngeal muscles (ILM) show biological differences from the broader class of skeletal muscles. Yet most research regarding ILM specialization has been completed on a few muscles, most notably the thyroarytenoid and posterior cricoarytenoid. Little information exists regarding the biology of other ILM. Early evidence suggests…

  4. Dietary phosphorus overload aggravates the phenotype of the dystrophin-deficient mdx mouse.

    Science.gov (United States)

    Wada, Eiji; Yoshida, Mizuko; Kojima, Yoriko; Nonaka, Ikuya; Ohashi, Kazuya; Nagata, Yosuke; Shiozuka, Masataka; Date, Munehiro; Higashi, Tetsuo; Nishino, Ichizo; Matsuda, Ryoichi

    2014-11-01

    Duchenne muscular dystrophy is a lethal X-linked disease with no effective treatment. Progressive muscle degeneration, increased macrophage infiltration, and ectopic calcification are characteristic features of the mdx mouse, a murine model of Duchenne muscular dystrophy. Because dietary phosphorus/phosphate consumption is increasing and adverse effects of phosphate overloading have been reported in several disease conditions, we examined the effects of dietary phosphorus intake in mdx mice phenotypes. On weaning, control and mdx mice were fed diets containing 0.7, 1.0, or 2.0 g phosphorus per 100 g until they were 90 days old. Dystrophic phenotypes were evaluated in cryosections of quadriceps and tibialis anterior muscles, and maximal forces and voluntary activity were measured. Ectopic calcification was analyzed by electron microscopy to determine the cells initially responsible for calcium deposition in skeletal muscle. Dietary phosphorus overload dramatically exacerbated the dystrophic phenotypes of mdx mice by increasing inflammation associated with infiltration of M1 macrophages. In contrast, minimal muscle necrosis and inflammation were observed in exercised mdx mice fed a low-phosphorus diet, suggesting potential beneficial therapeutic effects of lowering dietary phosphorus intake on disease progression. To our knowledge, this is the first report showing that dietary phosphorus intake directly affects muscle pathological characteristics of mdx mice. Dietary phosphorus overloading promoted dystrophic disease progression in mdx mice, whereas restricting dietary phosphorus intake improved muscle pathological characteristics and function.

  5. Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.

    Directory of Open Access Journals (Sweden)

    Thibaut Larcher

    Full Text Available A few animal models of Duchenne muscular dystrophy (DMD are available, large ones such as pigs or dogs being expensive and difficult to handle. Mdx (X-linked muscular dystrophy mice only partially mimic the human disease, with limited chronic muscular lesions and muscle weakness. Their small size also imposes limitations on analyses. A rat model could represent a useful alternative since rats are small animals but 10 times bigger than mice and could better reflect the lesions and functional abnormalities observed in DMD patients. Two lines of Dmd mutated-rats (Dmdmdx were generated using TALENs targeting exon 23. Muscles of animals of both lines showed undetectable levels of dystrophin by western blot and less than 5% of dystrophin positive fibers by immunohistochemistry. At 3 months, limb and diaphragm muscles from Dmdmdx rats displayed severe necrosis and regeneration. At 7 months, these muscles also showed severe fibrosis and some adipose tissue infiltration. Dmdmdx rats showed significant reduction in muscle strength and a decrease in spontaneous motor activity. Furthermore, heart morphology was indicative of dilated cardiomyopathy associated histologically with necrotic and fibrotic changes. Echocardiography showed significant concentric remodeling and alteration of diastolic function. In conclusion, Dmdmdx rats represent a new faithful small animal model of DMD.

  6. Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy.

    Science.gov (United States)

    Larcher, Thibaut; Lafoux, Aude; Tesson, Laurent; Remy, Séverine; Thepenier, Virginie; François, Virginie; Le Guiner, Caroline; Goubin, Helicia; Dutilleul, Maéva; Guigand, Lydie; Toumaniantz, Gilles; De Cian, Anne; Boix, Charlotte; Renaud, Jean-Baptiste; Cherel, Yan; Giovannangeli, Carine; Concordet, Jean-Paul; Anegon, Ignacio; Huchet, Corinne

    2014-01-01

    A few animal models of Duchenne muscular dystrophy (DMD) are available, large ones such as pigs or dogs being expensive and difficult to handle. Mdx (X-linked muscular dystrophy) mice only partially mimic the human disease, with limited chronic muscular lesions and muscle weakness. Their small size also imposes limitations on analyses. A rat model could represent a useful alternative since rats are small animals but 10 times bigger than mice and could better reflect the lesions and functional abnormalities observed in DMD patients. Two lines of Dmd mutated-rats (Dmdmdx) were generated using TALENs targeting exon 23. Muscles of animals of both lines showed undetectable levels of dystrophin by western blot and less than 5% of dystrophin positive fibers by immunohistochemistry. At 3 months, limb and diaphragm muscles from Dmdmdx rats displayed severe necrosis and regeneration. At 7 months, these muscles also showed severe fibrosis and some adipose tissue infiltration. Dmdmdx rats showed significant reduction in muscle strength and a decrease in spontaneous motor activity. Furthermore, heart morphology was indicative of dilated cardiomyopathy associated histologically with necrotic and fibrotic changes. Echocardiography showed significant concentric remodeling and alteration of diastolic function. In conclusion, Dmdmdx rats represent a new faithful small animal model of DMD.

  7. Martin Luther King, Jr. Resource Guide.

    Science.gov (United States)

    New York State Education Dept., Albany. Div. of Civil Rights and Intercultural Relations.

    This resource guide was developed to commemorate Dr. Martin Luther King, Jr.'s birthday by providing school personnel with background information and hands-on activities for use with students in Grades K-12. The activities in the guide can be implemented throughout the school year to help students become aware of the social, economic, and…

  8. The city of the divine king

    DEFF Research Database (Denmark)

    Barnow, Niels Finn

    2001-01-01

    The City of the Divine King deals with urban systems and urban architecture in the river kingdoms of the Near East and the agrarian societies of the Orient. The book is part of a larger work comprising studies of the antique Greek world and the Roman Empire and the later developments of cities an...

  9. Briti publik armastab King Kongi / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Briti filmiajakiri Empire lugejate filmiauhinnad : parim film "King Kong" (Peter Jackson), parim režii Steve Box, Nick Park "Wallace & Gromit - libaküüliku needus", parim meesnäitleja Johnny Depp, parim naisnäitleja Thandie Newton

  10. Briti publik armastab King Kongi / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2006-01-01

    Briti filmiajakiri Empire lugejate filmiauhinnad : parim film "King Kong" (Peter Jackson), parim režii Steve Box, Nick Park "Wallace & Gromit - libaküüliku needus", parim meesnäitleja Johnny Depp, parim naisnäitleja Thandie Newton

  11. Oedipus king: preparing man for the polis

    OpenAIRE

    José Joaquim Pereira Melo; Renan Willian Fernandes Gomes

    2013-01-01

    Having Sophoclean play Oedipus King as a frame of reference, the purpose of this paper is to discuss the educative proposal conceived to the Greek Man as preparation for life in the polis. Although not intentionally, Sophocles pointed out an ideal of Man which, in his perspective, would fulfill Greek societal demands of that time. Such society was divided between myth and rationality and, as a result, Man found Himself in conflict and lacking direction for His life. Given that, Oedipus’ chara...

  12. Drag kings in the new wave: gender performance and participation.

    Science.gov (United States)

    Surkan, Kim

    2002-01-01

    In an examination of Midwestern drag king performers and communities that have emerged since the study by Volcano and Halberstam of king cultures in London, New York, and San Francisco, this article considers traditional and alternative ways of "doing drag," both performative and participatory, as a means of interrogating the proximity of a "new wave" of king culture to academic theory. Tracing the evolution of drag king performance in the Twin Cities from the 1996 workshop by Diane Torr to the formation of two distinct king troupes in the late 1990s demonstrates a particular trajectory in kinging that reflects a new consciousness and enactment of gender theory through artistic praxis. Participation plays a key role in breaking down the distance between spectator and performer in venues such as the First International Drag King Extravaganza in Columbus, Ohio, and Melinda Hubman's art installation "Performing Masculinities: Take a Chance on Gender" in Minneapolis. By engaging the "audience" in drag, the Extravaganza "Science Fair" successfully referenced drag kings' shared history with early American freak shows in a clever and critical way. Moving beyond the contest framework of early king shows, new drag king troupes like Minneapolis' Dykes Do Drag are "mixing it up" in an attempt to complicate notions of butch/femme gender roles, sexuality, and drag stereotypes.

  13. Feeding performance of king Mackerel, Scomberomorus cavalla.

    Science.gov (United States)

    Ferguson, Amber R; Huber, Daniel R; Lajeunesse, Marc J; Motta, Philip J

    2015-08-01

    Feeding performance is an organism's ability to capture and handle prey. Although bite force is a commonly used metric of feeding performance, other factors such as bite pressure and strike speed are also likely to affect prey capture. Therefore, this study investigated static bite force, dynamic speeds, and predator and prey forces resulting from ram strikes, as well as bite pressure of the king mackerel, Scomberomorus cavalla, in order to examine their relative contributions to overall feeding performance. Theoretical posterior bite force ranged from 14.0-318.7 N. Ram speed, recorded with a rod and reel incorporated with a line counter and video camera, ranged from 3.3-15.8B L/s. Impact forces on the prey ranged from 0.1-1.9 N. Bite pressure, estimated using theoretical bite forces at three gape angles and tooth cross-sectional areas, ranged from 1.7-56.9 MPa. Mass-specific bite force for king mackerel is relatively low in comparison with other bony fishes and sharks, with relatively little impact force applied to the prey during the strike. This suggests that king mackerel rely on high velocity chases and high bite pressure generated via sharp, laterally compressed teeth to maximize feeding performance.

  14. A New Reading of Shakespeare's King John.

    Science.gov (United States)

    Usher, Peter D.

    1995-12-01

    Shakespeare wrote King John c.1594, six years after the defeat of the Spanish Armada, and ~ 50 years after publication of the Copernican heliocentric hypothesis. It is said to be the most unhistorical of the History Plays, ``anomalous'', ``puzzling'', and ``odd'', and as such it has engendered far more than the customary range of interpretive opinion. I suggest that the play alerts Elizabethans not just to military and political threats, but to a changing cosmic world view, all especially threatening as they arise in Catholic countries. (a) Personification characterizes the play. John personifies the old order, while Arthur and the Dauphin's armies personify the new. I suggest that Shakespeare decenters King John just as Copernicus decentered the world. (b) Hubert menaces Arthur's eyes for a whole scene (4.1), but the need for such cruelty is not explained and is especially odd as Arthur is already under sentence of death (3.3.65-66). This hitherto unexplained anomaly suggests that the old order fears what the new might see. (c) Eleanor's confession is made only to Heaven and to her son the King (1.1.42-43), yet by echoing and word play the Messenger from France later reveals to John that he is privy to it (4.2.119-124). This circumstance has not been questioned heretofore. I suggest that the Messenger is like the wily Hermes (Mercury), chief communicator of the gods and patron of the sciences; by revealing that he moves in the highest circles, he tells John that he speaks with an authority that transcends even that of a king. The message from on high presages more than political change; it warns of a new cosmic and religious world order (d) Most agree that John is a weak king, so Shakespeare must have suspected flaws in the old ways. He would have known that Tycho Brahe's new star of 1572, the comet of 1577, and the 1576 model of his compatriot Thomas Digges, were shattering old ideas. (e) The tensions of the play are not resolved because in 1594 the new order was

  15. Characterization of the complete mitochondrial genome of the king pigeon (Columba livia breed king).

    Science.gov (United States)

    Zhang, Rui-Hua; He, Wen-Xiao; Xu, Tong

    2015-06-01

    The king pigeon is a breed of pigeon developed over many years of selective breeding primarily as a utility breed. In the present work, we report the complete mitochondrial genome sequence of king pigeon for the first time. The total length of the mitogenome was 17,221 bp with the base composition of 30.14% for A, 24.05% for T, 31.82% for C, and 13.99% for G and an A-T (54.22 %)-rich feature was detected. It harbored 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one non-coding control region (D-loop region). The arrangement of all genes was identical to the typical mitochondrial genomes of pigeon. The complete mitochondrial genome sequence of king pigeon would serve as an important data set of the germplasm resources for further study.

  16. Goldie Brangman Remembers the Operation to Save Dr King.

    Science.gov (United States)

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led.

  17. A Palisade Fit for a King: Ideal architecture in King Harald Bluetooth's Jelling

    DEFF Research Database (Denmark)

    Jessen, Mads Dengsø; Holst, Mads Kähler; Lindblom, Charlotta;

    2014-01-01

    family named on the rune stones in Jelling and in particular to the reign of King Harald Bluetooth. In addition to the structure and date of the palisade, the article will present the tentative results from a series of analyses regarding the construction, composition, function and demolition...

  18. Blindness and Insight in King Lear

    Institute of Scientific and Technical Information of China (English)

    岳元玉

    2008-01-01

    This paper intends to explore how William Shakespeare illustrates the theme of blindness and insight in his great tragedy "King Lear".Four characters’ deeds and their fate are used as a case study to examine what blindness is,what insight is,and the relationship between the two.The writer finds that by depicting the characters’ deeds and their fate in a double plot,Shakespeare renders the folly of blindness,the transition from blindness to insight,and the use of reason and thought to understand the truth.

  19. Habitat Suitability Index Models: Red king crab

    Science.gov (United States)

    Jewett, Stephen C.; Onuf, Christopher P.

    1988-01-01

    A review and synthesis of existing information were used to develop a Habitat Suitability Index (HSI) model for evaluating habitat of different life stages of red king crab (Paralithodes camtschatica). A model consolidates habitat use information into a framework appropriate for field application, and is scaled to produce an index between 0.0 (unsuitable habitat) and 1.0 (optimum habitat) in Alaskan coastal waters, especially in the Gulf of Alaska and the southeastern Bering Sea. HSI models are designed to be used with Habitat Evaluation Procedures previously developed by the U.S. Fish and Wildlife Service.

  20. King customer forever: Customer satisfaction and beyond

    Directory of Open Access Journals (Sweden)

    Myuers James

    2004-01-01

    Full Text Available "King Customer!" So proclaimed the front cover of Business Week in a 1989 issue. At about the same time, "Rediscovering the Customer" was the title of a series of company vignettes in Fortune magazine. And a Wall Street Journal article asked, "For Customers, More Than Lip Service?" Combined, these three prestigious business publications reflected a new era in business firms perceptions of their customers and the role they should play in the formulation of company strategies and priorities. Had the "Era of the Customer" finally arrived in American business? .

  1. King Kong tuli unenäost / Alar Niineväli

    Index Scriptorium Estoniae

    Niineväli, Alar

    2005-01-01

    Hiigelgorilla King Kongi sünd kinolinal 1933.a. Merian C. Cooperi õudusfilmis "King Kong" ja koletise hilisemad tulemised, ka koos jaapanlaste Godzillaga (1962) ja Tarzaniga india filmis "Tarzan ja King Kong" (1965)

  2. King Kong tuli unenäost / Alar Niineväli

    Index Scriptorium Estoniae

    Niineväli, Alar

    2005-01-01

    Hiigelgorilla King Kongi sünd kinolinal 1933.a. Merian C. Cooperi õudusfilmis "King Kong" ja koletise hilisemad tulemised, ka koos jaapanlaste Godzillaga (1962) ja Tarzaniga india filmis "Tarzan ja King Kong" (1965)

  3. Martin Luther King, Jr.: The Dream of Peaceful Revolution.

    Science.gov (United States)

    Rowland, Della

    This biography for younger readers depicts the life of Martin Luther King, Jr., the Nobel Peace Prize winner who dedicated himself to the struggle for equal rights for African Americans while embracing the principle of nonviolent resistance. The book presents an overview of the civil rights movement and chronicles King's role as national leader…

  4. Keeping the Dream Alive. Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Cassells, Linda; And Others

    1993-01-01

    Presents activities for teaching elementary students about Dr. Martin Luther King's life, the civil rights movement, and King's accomplishments. Suggestions include shoebox dioramas, acronym games, oral histories, multicultural awareness activities, pledge cards, community service projects, special commemorative ceremonies, and a book of dreams.…

  5. King Harald V and Queen Sonja of Norway visit CERN

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    Norway's King Harald V and Queen Sonja take a tour of the ATLAS detector with CERN's Director-General Robert Aymar in April 2006. During their visit the royal party met with members of CERN's Norwegian community. A group of about 40 students greeted the royal motorcade with a belting rendition of 'The King's Song', Norway's royal anthem.

  6. An Archetypal Reading of Henderson the Ring King

    Institute of Scientific and Technical Information of China (English)

    时静

    2009-01-01

    Henderson the Rain King (1959) is one of Nobel Prize winner Saul Bellow's major and mature novels. Like many great works, this novel can be traced hack to some ancient archetypes. This thesis attempts to use axchetypal the-ories to probe into the archetypal quest theme in Henderson the Rain King.

  7. Henry David Thoreau and Martin Luther King, Jr. Lesson Plan.

    Science.gov (United States)

    Powell, Brent

    1995-01-01

    Presents a five-lesson, high school instructional unit on the ideas and activities of Henry David Thoreau and Martin Luther King, Jr. Includes student objectives, step-by-step instructional procedures, and discussion questions. Provides quotations by Thoreau and King. (CFR)

  8. Dr. Martin Luther King, Jr. Washington State Resource Guide.

    Science.gov (United States)

    Washington Office of the State Superintendent of Public Instruction, Olympia, WA. Div. of Instructional Programs and Services.

    The Washington State Resource Guide on Martin Luther King, Jr., supplies a wide variety of materials for use with all grade levels in classroom and assembly presentations in public schools. The goal is for every child enrolled in Washington State schools to learn about Dr. King during the days of January 15 to January 17. Resolutions supporting an…

  9. Author! Author! The Gallant Children's Author: Dick King-Smith

    Science.gov (United States)

    Brodie, Carolyn S.

    2005-01-01

    This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

  10. Une fresque hagiographique sur Martin Luther King

    OpenAIRE

    Portes, Jacques

    2015-01-01

    Ce film est sorti en prévision du cinquantième anniversaire des grandes manifestations de Selma (Alabama) de janvier-mars 1965, qui ont débouché en juillet suivant sur le vote de la loi du droit de vote qui va assurer aux électeurs noirs l’accès au suffrage, dont ils étaient privés dans le Sud depuis la fin du XIXe siècle. « Selma » a mis en avant une fois de plus la personnalité de Martin Luther King, à la fois prudent et déterminé, dont le rôle précédent avait été largement reconnu par son ...

  11. Cell scientist to watch - Megan King.

    Science.gov (United States)

    2016-12-15

    Megan king received her BA in biochemistry from Brandeis University and then pursued a PhD degree in Biochemistry and Molecular Biophysics at the University of Pennsylvania working in the group of Mark Lemmon. For her postdoctoral training, Megan chose the laboratory of Günter Blobel at the Rockefeller University in New York. Since starting her own group at the Cell Biology Department at Yale School of Medicine in 2009, Megan was named a Searle Scholar and her work has been recognised with the NIH Director's New Innovator Award in 2011. She is now an Associate professor for Cell Biology and her research focuses on chromatin dynamics, nuclear mechanics and live-cell assay development.

  12. Review - Scripture of the Ten Kings

    Directory of Open Access Journals (Sweden)

    Paul K. Nietupski

    2013-12-01

    Full Text Available Review of: Daniel Berounský (with Luboš Bělka, "Comparative Description of the Paintings". 2012. The Tibetan Version of the Scripture on the Ten Kings and the Quest for Chinese Influence on the Tibetan Perception of the Afterlife. Prague: Triton Publishing House. This book is a study of the various influences on the complex Tibetan visions of the afterlife. It is based on new text-critical research and includes an introduction and translation of a rare Tibetan manuscript entitled Scripture on the Ten Kings, housed in the National Gallery, Prague. The book includes extensive references to secondary scholarship, as well as collaborative work by competent scholars and an appended study of the text illustrations by Luboš Bělka From the outset, the book raises a range of interpretive questions of central importance to at least Tibetan and Asian studies. The author describes the plan of the book and its parameters in the Introduction, noting that the manuscript under study does not include tantric perspectives (12, and is instead more oriented to popular understanding and use. This is an important and controversial methodological position, consistent with the formalized one circulated in scholastic and monastic circles that emphasizes secrecy and limited access to fully developed tantric studies. This position can, however, be contrasted with, for example, the uses of texts noted by Cuevas (2003, and further emphasized by Prude (2005:1-3, who suggests more popular use of tantric texts. This view is discussed in detail by others, including Thurman (2006, in his obviously tantric-influenced introduction and translation of the..

  13. King County Metro Transit Hybrid Articulated Buses: Final Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Walkowicz, K.

    2006-12-01

    Final technical report compares and evaluates new diesel and diesel hybrid-electric articulated buses operated as part of the King County Metro Transit (KC Metro) fleet in Seattle, Washington. The evaluation lasted 12 months.

  14. The Influence of Martin Luther King on Education

    Science.gov (United States)

    Harper, Frederick D.

    1973-01-01

    In a sense, Martin Luther King was an educator whose students composed citizens of the United States, whose classroom encompassed the entire country, and whose course contents and lesson plans included civil rights, race relations, human rights, and love. (Author)

  15. Monkey King by Zhengjiang General Troupe of Quyi and Acrobatics

    Institute of Scientific and Technical Information of China (English)

    王玉

    2008-01-01

    Monkey King,the grand acrobatic and magical theme show, has successfully given its first dozen shows at Hangzhou Theater since July 27.The show was presented by Zhejiang General Troupe of Quyi and Acrobatics, and

  16. Dragon-kings: mechanisms, statistical methods and empirical evidence

    CERN Document Server

    Sornette, D; 10.1140/epjst/e2012-01559-5

    2012-01-01

    This introductory article presents the special Discussion and Debate volume "From black swans to dragon-kings, is there life beyond power laws?" published in Eur. Phys. J. Special Topics in May 2012. We summarize and put in perspective the contributions into three main themes: (i) mechanisms for dragon-kings, (ii) detection of dragon-kings and statistical tests and (iii) empirical evidence in a large variety of natural and social systems. Overall, we are pleased to witness significant advances both in the introduction and clarification of underlying mechanisms and in the development of novel efficient tests that demonstrate clear evidence for the presence of dragon-kings in many systems. However, this positive view should be balanced by the fact that this remains a very delicate and difficult field, if only due to the scarcity of data as well as the extraordinary important implications with respect to hazard assessment, risk control and predictability.

  17. King Cove, Alaska Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The King Cove, Alaska Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST) model. MOST...

  18. AFSC/RACE/SAP/Urban: Golden King Crab tagging

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data is comprised of the records of individual male golden king crab (GKC) tagged at the Kodiak Laboratory. Initial size, shell condition and missing limbs was...

  19. Dragon-Kings, Black Swans and the Prediction of Crises

    CERN Document Server

    Sornette, Didier

    2009-01-01

    We develop the concept of ``dragon-kings'' corresponding to meaningful outliers, which are found to coexist with power laws in the distributions of event sizes under a broad range of conditions in a large variety of systems. These dragon-kings reveal the existence of mechanisms of self-organization that are not apparent otherwise from the distribution of their smaller siblings. We present a generic phase diagram to explain the generation of dragon-kings and document their presence in six different examples (distribution of city sizes, distribution of acoustic emissions associated with material failure, distribution of velocity increments in hydrodynamic turbulence, distribution of financial drawdowns, distribution of the energies of epileptic seizures in humans and in model animals, distribution of the earthquake energies). We emphasize the importance of understanding dragon-kings as being often associated with a neighborhood of what can be called equivalently a phase transition, a bifurcation, a catastrophe ...

  20. Population dynamics of the king rails, Rallus elegans

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report describes the findings of research conducted by a team of biologists from East Carolina University. The project ‘Population Dynamics of the King Rail,...

  1. Analysis of astronomical records of King Wu's Conquest

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    All related astronomical records of King Wu's Conquest have been searched and analysed comprehensively. Constrained by the newest conclusions of archeology, philology and history in the Xia-Shang-Zhou Chronology Project and based mainly on dates in Wucheng, Jupiter's position in Guoyu and information on the season, our first choice of the date of King Wu's Conquest is Jun. 20, BC1046. This conclusion explains properly most relevant literature.

  2. Den radikale Kings skandinaviske drøm

    DEFF Research Database (Denmark)

    Brøndal, Jørn

    2013-01-01

    I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale......I dag forgudes Martin Luther King for sin racemæssige vision. Derimod aner de fleste amerikanere ikke noget om hans økonomiske ideer, og hvis de gjorde, ville mange af dem utvivlsomt affeje dem som alt for radikale...

  3. Judas Iscariot: The Archetypal Betrayer and DeMille’s Cine-Biblical Salvation within The King of Kings (1927)

    OpenAIRE

    Anton Karl Kozlovic

    2008-01-01

    Cecil B. DeMille, the legendary cofounder of Hollywood, progenitor of Paramount studio, and unsung Christian auteur was a master of the American biblical epic whose indelible classics became the template for numerous ancient epics thereafter. Utilising humanist film criticism as the guiding analytical lens, the critical DeMille, film and religion literature was selectively reviewed and his silent Jesus film, The King of Kings (1927) was closely examined to reveal his dramatic construction of ...

  4. The 'Byzantinisms' of king Stefan Radoslav

    Directory of Open Access Journals (Sweden)

    Maksimović Ljubomir

    2009-01-01

    Full Text Available The life-style and politics of Stefan Radoslav bear the mark of activities that indicated his special attachment to the Byzantine world. These activities were prompted by a combination of ideological ambitions and political reality, but they were not in keeping with the modest achievements of Radoslav's reign. Moreover, most of these activities belong to the time when Radoslav was heir to the throne. There is no doubt that Stefan Nemanjić the Grand Zhupan and subsequently the first crowned king, had exclusive connections with the Byzantine dynasty of the Angeloi, especially with the emperor Alexios III (1195-1203. In that context, the donor's inscription in the basic ring of the dome in the Church of the Mother of God in Studenica (1208, in which his father Stefan Nemanja, is mentioned as (former 'veleslavni gospodin vse srbske zemlje veli(ki župan i svat cara grčkog kir Alesija', is quite indicative. This ideological construction would acquire a contour in reality by means of a political marriage with one of the female offspring of Angeloi lineage, which would represent an alternative solution to Stefan's failed marriage with Eudocia, daughter of the emperor Alexios. Instead, several years elapsed in waging war with the Latins, the Bulgarians and the State of Epiros. However, efforts to create firmer, more tangible ties with the Angeloi dynasty from Epiros were not forgotten. Therefore, the Serbian monarch brought his eldest son Radoslav into play, intending to have him act as a link with the Angeloi bloodline. As a result of all this, the final attempt to have Radoslav become the husband of a princess from the Angelos dynasty is not surprising. At the end of 1219 or the beginning of 1220, he married Anna Doukaina, the daughter of the epirotic ruler Theodore I Angelos Doukas Komnenos, which at that point represented a marriage connection of the highest possible level between two ruling houses. Stefan's insistence on Serbia acquiring a stake

  5. C. Judson King of UC Berkeley

    Energy Technology Data Exchange (ETDEWEB)

    Prausnitz, John

    2005-06-01

    In the middle of the UC Berkeley campus, next to the Main Library, South Hall is the last surviving building from the original campus, founded about 135 years ago. A tiny tree-shaded appendix to this venerated classical building houses Berkeley's Center for Studies in Higher Education, directed by C. Judson King, former Provost and Senior Vice President--Academic Affairs of the ten-campus University of California and long-time Professor of Chemical Engineering at Berkeley. Jud came to Berkeley in 1963 as assistant professor of chemical engineering, following receipt of a doctor's degree from MIT and a subsequent short appointment as director of the MIT chemical engineering practice school station at what was then Esso (now Exxon) in New Jersey. His undergraduate degree is from Yale. Starting with his MIT doctoral dissertation on gas absorption, Jud has devoted much of his professional career to separation processes. His teaching and research activities have been primarily concerned with separation of mixtures with emphasis on liquid-liquid extraction and drying. As a consultant to Procter and Gamble, he contributed to the technology of making instant coffee. His life-long activities in hiking and camping stimulated Jud's interest in the manufacture of freeze-dried foods (e.g. turkey meat) to minimize the weight of his hiking back-pack. Jud is internationally known not only for his many research publications but even more, for his acclaimed textbook ''Separation Processses'' (McGraw-Hill, second edition 1980) that is used in standard chemical engineering courses in the US and abroad.

  6. The Foolish King (A Folktale of the Uzbek Ethnic Nationality)

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    ONCE upon a time, there was a poor man who had himself a hut. Because he had little money he had the roof made of a thin layer of poor quality straw matting. One night a thief came. He mounted the roof to see if there was any chance of getting into the house. But the straw mats could not stand his weight and he went right through the roof and fell onto the poor man, who was sound asleep. The thief was annoyed, and went to the King first timing in the morning. "Your Majesty," he said to the King, "I am a thief who knows my job very well. But last night I couldn’t steal anything. Instead, I broke my leg." The King sent for the poor man immediately. "It’s true, your Majesty," said the poor man when he arrived. "Then you must be sent to the gallows," announced the King, and ordered the gallows to be readied at once. Seeing what a fool the King was, the poor man cried, "I’m innocent, Your Majesty. It is the hut-builder who is guilty, because he didn’t build the roof strong enough."

  7. The open cluster King 1 in the second quadrant

    Science.gov (United States)

    Carrera, Ricardo; Rodríguez Espinosa, Loreto; Casamiquela, Laia; Balaguer Nuñez, Lola; Jordi, Carme; Allende Prieto, Carlos; Stetson, Peter B.

    2017-10-01

    We analyse the poorly studied open cluster King 1 in the second Galactic quadrant. From wide-field photometry, we have studied the spatial distribution of this cluster. We determined that the centre of King 1 is located at α2000 = 00h22m and δ2000 = +64°23΄. By parameterizing the stellar density with a King profile, we have obtained a central density of ρ0 = 6.5 ± 0.2 star arcmin-2 and a core radius of rcore = 1.9 ± 0.2 arcmin. By comparing the observed colour-magnitude diagram of King 1 with those of similar open clusters and with different sets of isochrones, we have estimated an age of 2.8 ± 0.3 Gyr, a distance modulus of (m - M)o = 10.6 ± 0.1 mag and a reddening of E(B - V) = 0.80 ± 0.05 mag. To complete our analysis, we acquired medium resolution spectra for 189 stars in the area of King 1. From their derived radial velocities, we determined an average velocity = -53.1 ± 3.1 km s-1. From the strength of the infrared Ca ii lines in red giants we have determined an average metallicity of = +0.07 ± 0.08 dex. From spectral synthesis, we have also estimated an α-elements abundance of = -0.10 ± 0.08 dex.

  8. Ancestry and pathology in King Tutankhamun's family.

    Science.gov (United States)

    Hawass, Zahi; Gad, Yehia Z; Ismail, Somaia; Khairat, Rabab; Fathalla, Dina; Hasan, Naglaa; Ahmed, Amal; Elleithy, Hisham; Ball, Markus; Gaballah, Fawzi; Wasef, Sally; Fateen, Mohamed; Amer, Hany; Gostner, Paul; Selim, Ashraf; Zink, Albert; Pusch, Carsten M

    2010-02-17

    The New Kingdom in ancient Egypt, comprising the 18th, 19th, and 20th dynasties, spanned the mid-16th to the early 11th centuries bc. The late 18th dynasty, which included the reigns of pharaohs Akhenaten and Tutankhamun, was an extraordinary time. The identification of a number of royal mummies from this era, the exact relationships between some members of the royal family, and possible illnesses and causes of death have been matters of debate. To introduce a new approach to molecular and medical Egyptology, to determine familial relationships among 11 royal mummies of the New Kingdom, and to search for pathological features attributable to possible murder, consanguinity, inherited disorders, and infectious diseases. From September 2007 to October 2009, royal mummies underwent detailed anthropological, radiological, and genetic studies as part of the King Tutankhamun Family Project. Mummies distinct from Tutankhamun's immediate lineage served as the genetic and morphological reference. To authenticate DNA results, analytical steps were repeated and independently replicated in a second ancient DNA laboratory staffed by a separate group of personnel. Eleven royal mummies dating from circa 1410-1324 bc and suspected of being kindred of Tutankhamun and 5 royal mummies dating to an earlier period, circa 1550-1479 bc, were examined. Microsatellite-based haplotypes in the mummies, generational segregation of alleles within possible pedigree variants, and correlation of identified diseases with individual age, archeological evidence, and the written historical record. Genetic fingerprinting allowed the construction of a 5-generation pedigree of Tutankhamun's immediate lineage. The KV55 mummy and KV35YL were identified as the parents of Tutankhamun. No signs of gynecomastia and craniosynostoses (eg, Antley-Bixler syndrome) or Marfan syndrome were found, but an accumulation of malformations in Tutankhamun's family was evident. Several pathologies including Köhler disease

  9. Review the Nature and the Humanity in King Lear

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhi-lan

    2015-01-01

    Tragedy is the art that purifies the mind. Through richly-drawn impressive characters, King Lear illustrates the same⁃ness of human nature and manifest the common outlook on humanity in Chinese and western culture. King Lear should be studied from the perspectives of dialectics of nature and history of social development.Through manifestation of nature and human beings, King Lear proves to be deeply touching for being earthshaking, society-changing and mind-purifying.The artistic value of this trag⁃edy lies in that the truth, the good and the beauty against the fake,the bad and the ugly. All these contributes to its extraordinary standing in aesthetics, philosophy, anthropology, sociology and psychology.

  10. Naval submarine base Kings Bay and Bangor soil evaluations.

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, David Joseph; Patteson, Raymond; Wesenberg, Donald L.; Attaway, Stephen W.

    2004-08-01

    This report provides soil evaluation and characterization testing for the submarine bases at Kings Bay, Georgia, and Bangor, Washington, using triaxial testing at high confining pressures with different moisture contents. In general, the samples from the Bangor and Kings Bay sites appeared to be stronger than a previously used reference soil. Assuming the samples of the material were representative of the material found at the sites, they should be adequate for use in the planned construction. Since soils can vary greatly over even a small site, a soil specification for the construction contractor would be needed to insure that soil variations found at the site would meet or exceed the requirements. A suggested specification for the Bangor and Kings Bay soils was presented based on information gathered from references plus data obtained from this study, which could be used as a basis for design by the construction contractor.

  11. King James II Stuart, Irish Elites and Patriot Parliament

    Directory of Open Access Journals (Sweden)

    Stankov Kirill Nikolaevich

    2014-09-01

    Full Text Available The article is devoted to the insufficiently studied episode of the “Glorious revolution” of 1688-1689, the political fight on Green Island. On the basis of historical sources, the author shows the main directions of Irish policy of last catholic king James II, who tried to fight for his lost British throne, because the majority of population of this catholic country remained loyal to his patron. The author pays special attention to investigating the policy of different ethnic groups represented in Patriot Parliament by their elites. There were two elite groups who supported king James II and tried to influence him: “Old English” aristocracy and “Old Irish” nobility. King’s own elite group also consisted of “New English” and “New Scots”, but during the “Glorious revolution” the majority of them supported the counterpart of king James II – William Orange. Basing the study on historical sources the author proves that eventually king James II had two groups of supporters: “Old English” and “native Irish”. The article is concerned with non-investigated problem of negotiations between king James II and Irish elites and analyses the demands of the last. The author proves that acts and decisions of patriot parliament were the Irish population’s answers to the program and suggestions of king James II and that the main concessions were given to “Old English” aristocracy. The demands of “Old Irish” in agrarian issue were mainly ignored. The Patriot Parliament based the foundations of Jacobite political regime in Ireland during the restoration rebellion of 1689-1691.

  12. The Character Construction of Simba in The Lion King

    Institute of Scientific and Technical Information of China (English)

    黄婷婷

    2015-01-01

    The Lion King(1994)told the story of little lion Simba who experienced growth,death,love and responsibility,and finally overcame himself and the enemy and got the throne of the king of the forest,and became the hero of lion herd.As the soul character of the movie,Simba plays a very important role to the whole story.This paper examines Simba's personality features,through analyzing thefunction of character design and plot in construction of character,and attempts to explore how the heroic character Simba is constructed step by step.

  13. The Character Construction of Simba in The Lion King

    Institute of Scientific and Technical Information of China (English)

    黄婷婷

    2015-01-01

    The Lion King(1994)told the story of little lion Simba who experienced growth,death,love and responsibility,and finally overcame himself and the enemy and got the throne of the king of the forest,and became the hero of lion herd.As the soul character of the movie,Simba plays a very important role to the whole story.This paper examines Simba’s personality features,through analyzing the function of character design and plot in construction of character,and attempts to explore how the heroic character Simba is constructed step by step.

  14. The leaders King Sverre and King Haakon : analysis of King Sverre Sigurdsson and King Haakon Haakonsson in Sverris Saga and Haakonar Saga Haakonarsonar through Max Weber's and John Gardner's models

    OpenAIRE

    Osornio, Ismael Jose Duran

    2004-01-01

    The leadership of the Norwegian Kings during the Medieval ‘Civil War’ plays a prominent part in social, political and economical life in high Medieval Norway. The objective of the present dissertation discusses how King Sverre Sigurdsson (1177-1202) and Haakon Haakonsson (1217-1263) are depicted in their Sagas. The work will be focus on four analytical tools: 1. The Kings’ Charisma; 2. The Kings’ Personal Abilities; 3. The Kings’ Bureaucracy; 4. The King’s closest Fellows. The thesis goal wil...

  15. Monkey King —Prime Candidate for 2008 Olympics Mascot

    Institute of Scientific and Technical Information of China (English)

    LIDAOYING; YOUZHENGJUN; LIWUZHOU

    2003-01-01

    IS the monkey an appropriate 2008 Olympic mascot? No one will know for sure until next year. Now that the Chinese Seal has been officially des-ignated as the 2008 Olympics emblem,the games'' mascot has taken over as hot topic. Animal images like the panda, dragon, lion, tiger, Tibetan ante-lope, and rabbit are also under consid-eration, but monkeyking2008.com, a website promoting the Monkey King as 2008 Olympics mascot, reports that 89 percent of its visitors want the monkey. Results of a survey conducted by China''s largest portal site, Sina.com, also indicate the Monkey King as hot favorite for mascot.

  16. King's theory of goal attainment: exploring functional status.

    Science.gov (United States)

    Caceres, Billy A

    2015-04-01

    Imogene King's Theory of Goal Attainment provides a schema for nurses interested in functional status. However, the lack of a uniform definition for functional status has hindered development of a concise understanding of this phenomenon. Functional status is particularly important to nurses who are concerned with the safety and wellbeing of clients. With healthcare's increased focus on client-family-centered care it is important to develop innovative approaches for evaluating functional status that incorporate the client-family perspective. King's focus on mutual decision-making is an underutilized resource that can provide great insight into the study and understanding of functional status.

  17. Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency

    Science.gov (United States)

    Southard, Sheryl; Kim, Ju-Ryoung; Low, SiewHui; Tsika, Richard W; Lepper, Christoph

    2016-01-01

    When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon trauma. Yet, little is known regarding the mechanistic basis controlling initial and homeostatic ‘scaling’ of stem cell pool sizes relative to their target tissues for effective regeneration. Here, we show that TEAD1-expressing skeletal muscle of transgenic mice features a dramatic hyperplasia of muscle stem cells (i.e. satellite cells, SCs) but surprisingly without affecting muscle tissue size. Super-numeral SCs attain a ‘normal’ quiescent state, accelerate regeneration, and maintain regenerative capacity over several injury-induced regeneration bouts. In dystrophic muscle, the TEAD1 transgene also ameliorated the pathology. We further demonstrate that hyperplastic SCs accumulate non-cell-autonomously via signal(s) from the TEAD1-expressing myofiber, suggesting that myofiber-specific TEAD1 overexpression activates a physiological signaling pathway(s) that determines initial and homeostatic SC pool size. We propose that TEAD1 and its downstream effectors are medically relevant targets for enhancing muscle regeneration and ameliorating muscle pathology. DOI: http://dx.doi.org/10.7554/eLife.15461.001 PMID:27725085

  18. Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.

    Science.gov (United States)

    Giacomotto, Jean; Pertl, Cordula; Borrel, Caroline; Walter, Maggie C; Bulst, Stefanie; Johnsen, Bob; Baillie, David L; Lochmüller, Hanns; Thirion, Christian; Ségalat, Laurent

    2009-11-01

    Duchenne Muscular Dystrophy is an inherited muscle degeneration disease for which there is still no efficient treatment. However, compounds active on the disease may already exist among approved drugs but are difficult to identify in the absence of cellular models. We used the Caenorhabditis elegans animal model to screen a collection of 1000 already approved compounds. Two of the most active hits obtained were methazolamide and dichlorphenamide, carbonic anhydrase inhibitors widely used in human therapy. In C. elegans, these drugs were shown to interact with CAH-4, a putative carbonic anhydrase. The therapeutic efficacy of these compounds was further validated in long-term experiments on mdx mice, the mouse model of Duchenne Muscular Dystrophy. Mice were treated for 120 days with food containing methazolamide or dichlorphenamide at two doses each. Musculus tibialis anterior and diaphragm muscles were histologically analyzed and isometric muscle force was measured in M. extensor digitorum longus. Both substances increased the tetanic muscle force in the treated M. extensor digitorum longus muscle group, dichlorphenamide increased the force significantly by 30%, but both drugs failed to increase resistance of muscle fibres to eccentric contractions. Histological analysis revealed a reduction of centrally nucleated fibers in M. tibialis anterior and diaphragm in the treated groups. These studies further demonstrated that a C. elegans-based screen coupled with a mouse model validation strategy can lead to the identification of potential pharmacological agents for rare diseases.

  19. Effective exon skipping and dystrophin restoration by 2'-o-methoxyethyl antisense oligonucleotide in dystrophin-deficient mice.

    Directory of Open Access Journals (Sweden)

    Lu Yang

    Full Text Available Antisense oligonucleotide (AO-mediated exon-skipping therapy is one of the most promising therapeutic strategies for Duchenne Muscular Dystrophy (DMD and several AO chemistries have been rigorously investigated. In this report, we focused on the effect of 2'-O-methoxyethyl oligonucleotides (MOE on exon skipping in cultured mdx myoblasts and mice. Efficient dose-dependent skipping of targeted exon 23 was achieved in myoblasts with MOE AOs of different lengths and backbone chemistries. Furthermore, we established that 25-mer MOE phosphorothioate (PS AOs provided the greatest exon-skipping efficacy. When compared with 2'O methyl phosphorothioate (2'OmePS AOs, 25-mer MOE (PS AOs also showed higher exon-skipping activity in vitro and in mdx mice after intramuscular injections. Characterization of uptake in vitro corroborated with exon-skipping results, suggesting that increased uptake of 25-mer MOE PS AOs might partly contribute to the difference in exon-skipping activity observed in vitro and in mdx mice. Our findings demonstrate the substantial potential for MOE PS AOs as an alternative option for the treatment of DMD.

  20. Eosinophilia of dystrophin-deficient muscle is promoted by perforin-mediated cytotoxicity by T cell effectors

    Science.gov (United States)

    Cai, B.; Spencer, M. J.; Nakamura, G.; Tseng-Ong, L.; Tidball, J. G.

    2000-01-01

    Previous investigations have shown that cytotoxic T lymphocytes (CTLs) contribute to muscle pathology in the dystrophin-null mutant mouse (mdx) model of Duchenne muscular dystrophy through perforin-dependent and perforin-independent mechanisms. We have assessed whether the CTL-mediated pathology includes the promotion of eosinophilia in dystrophic muscle, and thereby provides a secondary mechanism through which CTLs contribute to muscular dystrophy. Quantitative immunohistochemistry confirmed that eosinophilia is a component of the mdx dystrophy. In addition, electron microscopic observations show that eosinophils traverse the basement membrane of mdx muscle fibers and display sites of close apposition of eosinophil and muscle membranes. The close membrane apposition is characterized by impingement of eosinophilic rods of major basic protein into the muscle cell membrane. Transfer of mdx splenocytes and mdx muscle extracts to irradiated C57 mice by intraperitoneal injection resulted in muscle eosinophilia in the recipient mice. Double-mutant mice lacking dystrophin and perforin showed less eosinophilia than was displayed by mdx mice that expressed perforin. Finally, administration of prednisolone, which has been shown previously to reduce the concentration of CTLs in dystrophic muscle, produced a significant reduction in eosinophilia. These findings indicate that eosinophilia is a component of the mdx pathology that is promoted by perforin-dependent cytotoxicity of effector T cells. However, some eosinophilia of mdx muscle is independent of perforin-mediated processes.

  1. Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging

    Directory of Open Access Journals (Sweden)

    Zhong Jia

    2009-10-01

    Full Text Available Abstract Background Duchenne muscular dystrophy (DMD is caused by the absence of the cytoskeletal protein, dystrophin. In DMD patients, dilated cardiomyopathy leading to heart failure may occur during adolescence. However, early cardiac dysfunction is frequently undetected due to physical inactivity and generalized debilitation. The objective of this study is to determine the time course of cardiac functional alterations in mdx mouse, a mouse model of DMD, by evaluating regional ventricular function with CMR tagging. Methods In vivo myocardial function was evaluated by 3D CMR tagging in mdx mice at early (2 months, middle (7 months and late (10 months stages of disease development. Global cardiac function, regional myocardial wall strains, and ventricular torsion were quantified. Myocardial lesions were assessed with Masson's trichrome staining. Results Global contractile indexes were similar between mdx and C57BL/6 mice in each age group. Histology analysis showed that young mdx mice were free of myocardial lesions. Interstitial fibrosis was present in 7 month mdx mice, with further development into patches or transmural lesions at 10 months of age. As a result, 10 month mdx mice showed significantly reduced regional strain and torsion. However, young mdx mice showed an unexpected increase in regional strain and torsion, while 7 month mdx mice displayed similar regional ventricular function as the controls. Conclusion Despite normal global ventricular function, CMR tagging detected a biphasic change in myocardial wall strain and torsion, with an initial increase at young age followed by progressive decrease at older ages. These results suggest that CMR tagging can provide more sensitive measures of functional alterations than global functional indexes in dystrophin-related cardiomyopathies.

  2. AFSC/RACE/SAP/Long: Data from: Embryo development in golden king crab, Lithodes aequispina.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data from this study, describes embryo development in Golden king crab, Lithodes aequispinus. Six female multiparous golden king crab were captured from the...

  3. Martin Luther King Jr. contest winning posters to be displayed in downtown Blacksburg

    OpenAIRE

    Shannon, Kelly Baker

    2010-01-01

    Each year as part of the Martin Luther King Jr. celebration at Virginia Tech area kindergarten through 12th grade students are invited to participate in the annual Martin Luther King Jr. poster contest.

  4. The Inaccuracies in the Reprintings of Martin Luther King's "I Have a Dream" Speech.

    Science.gov (United States)

    Bosmajian, Haig

    1982-01-01

    Identifies the additions, deletions, and changes in the reprinted versions of King's classic speech. (Serves both as a warning that published speeches cannot be depended upon to preserve the original text and as a source of reference for teachers using Dr. King.s speech in classroom study.) (PD)

  5. Commemoration of Dr. Martin Luther King, Jr., January 15, 1929-April 4, 1968. Revised.

    Science.gov (United States)

    Montgomery County Public Schools, Rockville, MD.

    Developed in honor of Dr. Martin Luther King, Jr., this is a short collection of suggested activities to teach black awareness in the elementary and secondary grades through King's philosophy. An introductory biographical sketch of King and an article about his accomplishments are provided. Activities are divided into grade-level ranges for the…

  6. 78 FR 39599 - Safety Zone; Independence Day Fireworks, Kings Beach, CA

    Science.gov (United States)

    2013-07-02

    ... SECURITY Coast Guard 33 CFR Part 165 Safety Zone; Independence Day Fireworks, Kings Beach, CA AGENCY: Coast... safety zone for the Independence Day Fireworks, Kings Beach, CA in the Captain of the Port, San Francisco... Marina to the launch site off of Kings Beach, CA in approximate position 39 13'55'' N, 120 01'42'' W...

  7. 77 FR 38005 - Safety Zone; Independence Day Fireworks, Kings Beach, CA

    Science.gov (United States)

    2012-06-26

    ... SECURITY Coast Guard 33 CFR Part 165 Safety Zone; Independence Day Fireworks, Kings Beach, CA AGENCY: Coast... safety zone for the Kings Beach Independence Day Fireworks display from 7 a.m. until 10 p.m. on July 3... from Tahoe Keys Marina to the launch site off of Kings Beach, CA at position 39 13'55'' N, 120...

  8. Let Freedom Ring: The Life & Legacy of Martin Luther King, Jr. [Lesson Plan].

    Science.gov (United States)

    National Endowment for the Humanities (NFAH), Washington, DC.

    This lesson plan teaches students about the life and work of Martin Luther King, Jr. Students listen to a brief biography, view photographs of the March on Washington, and read a portion of King's "I Have a Dream" speech. After studying Dr. King's use of imagery and allusion, students create original poetic phrases about freedom and…

  9. Henry David Thoreau, Martin Luther King Jr., and the American Tradition of Protest.

    Science.gov (United States)

    Powell, Brent

    1995-01-01

    Maintains that Henry David Thoreau and Martin Luther King, Jr. fundamentally altered the tradition of protest and reform. Compares and contrasts the role of each man in U.S. social and constitutional history. Concludes that while Thoreau lacked the broad influence of King, his writings influenced both King and Mohandas Gandhi. (CFR)

  10. New Light on the Legendary King Nechepsos of Egypt

    DEFF Research Database (Denmark)

    Ryholt, Kim

    2011-01-01

    This paper identifies several indigenous Egyptian attestations of King Nechepsos, previously well known from Classical sources. The name may be understood as ‘Necho the Wise’, and refers to Necho II of the Twenty-sixth Dynasty. His association with astrology may be related to an eclipse near...

  11. 76 FR 3819 - Martin Luther King, Jr., Federal Holiday, 2011

    Science.gov (United States)

    2011-01-20

    ... the President of the United States of America A Proclamation Half a century ago, America was moved by a young preacher who called a generation to action and forever changed the course of history. The... recognizing one of America's greatest visionary leaders, and we celebrate the life and legacy of Dr. King....

  12. Gold King Mine Release New Mexico Response Activities

    Science.gov (United States)

    DALLAS - (August 8, 2015) EPA Region 6 deployed a federal on-scene coordinator from its emergency response team and scientific technicians under contract to EPA to assist the state in preparations for the potential impacts from the Gold King Mine re

  13. Littoral Encounters : The Shore as Cultural Interface in King Horn

    NARCIS (Netherlands)

    Sobecki, Sebastian

    2006-01-01

    1. III * Later Medieval: Excluding Chaucer -- Brown et al., 10.1093 ... ... between the Saracens and the londisse men allied to the protagonist (' Littoral Encounters: the Shore as Cultural Interface in King Horn', Al-Mas a ... www.ywes.oxfordjournals.org/cgi/content/full/man0092 2.Murray, Alan V. “

  14. Mutual mate choice for olorful traits in King Penguins

    NARCIS (Netherlands)

    Nolan, Paul M.; Dobson, F. Stephen; Nicolaus, Marion; Karels, Tim J.; McGraw, Kevin J.; Jouventin, Pierre

    2010-01-01

    While studies of mate choice based on male color pattern are ubiquitous, studies of mate choice based on ornamental color traits in sexually monomorphic species are less common. We conducted manipulative field experiments on two color ornaments of king penguins (Aptenodytes patagonicus), the size of

  15. Time Analysis Of King Matthias the Ist Sculptural Group

    Directory of Open Access Journals (Sweden)

    Julieta Daniela CHELARU

    2010-06-01

    Full Text Available The paper presents a study on the degradation of the King Matthias I sculptural group, caused by environment factors and influenced by the casting technology and by the assembling method. During this study, samples from inside the statue were used and analyzed, using microscopy and X ray diffraction.

  16. NEA President Don Morrison Interviews Mrs. Martin Luther King, Jr.

    Science.gov (United States)

    Morrison, Don

    1972-01-01

    Civil rights leader's widow suggests activities conducive to peaceful social change, including Foundation-released film. Describes King Atlanta Center's plans for teacher-training in nonviolent means to attack poverty, fortify women's rights, improve race relations and black representation, end segregation outside South. (PD)

  17. Shame, recognition and love in Shakespeare’s 'King Lear'

    DEFF Research Database (Denmark)

    Montes Sanchez, Alba

    2014-01-01

    In this paper, I explore the experience of shame and its connections to recognition and love as manifested in Shakespeare’s King Lear. My main focus in this paper is the ethical relevance of shame. I start from Sartre’s account of shame in Being and Nothingness, and I consider Webber’s attempt to...

  18. Shame, recognition and love in Shakespeare’s 'King Lear'

    DEFF Research Database (Denmark)

    Montes Sanchez, Alba

    2014-01-01

    In this paper, I explore the experience of shame and its connections to recognition and love as manifested in Shakespeare’s King Lear. My main focus in this paper is the ethical relevance of shame. I start from Sartre’s account of shame in Being and Nothingness, and I consider Webber’s attempt...

  19. Dr. Martin Luther King: A Unit for Primary Grades.

    Science.gov (United States)

    Sweet, Kelli

    1986-01-01

    Presents a unit consisting of 4 lessons which focus on Dr. Martin Luther King, Jr.'s childhood, his adult life and family, his civil rights work, and the national holiday which commemorates his birthday. Each lesson features specific objectives, learning activities, and instructional guidelines for the teacher. (TRS)

  20. Celebrate the legacy of Dr. Martin Luther King Jr.

    OpenAIRE

    Lazenby, Jenna

    2006-01-01

    In celebration of the life and legacy of Dr. Martin Luther King, Jr., Virginia Tech will host a variety of educational and cultural programs and community service events Jan. 14-19, 2007. All events are free and open to the public.

  1. Mutual mate choice for olorful traits in King Penguins

    NARCIS (Netherlands)

    Nolan, Paul M.; Dobson, F. Stephen; Nicolaus, Marion; Karels, Tim J.; McGraw, Kevin J.; Jouventin, Pierre

    While studies of mate choice based on male color pattern are ubiquitous, studies of mate choice based on ornamental color traits in sexually monomorphic species are less common. We conducted manipulative field experiments on two color ornaments of king penguins (Aptenodytes patagonicus), the size of

  2. Secrets of the ‘King of Cable’

    Institute of Scientific and Technical Information of China (English)

    ANDY; ZHAI

    2007-01-01

    From watch repairman to cable magnate, Jiang Xipei takes success in his stride Jiang Xipei, Chairman of Far East Group, has worked his way up from being an ordinary watch repairman to being China’s 'King of Cable'-leading his company to a ranking of 30t

  3. Making Sense of the Senseless: The Murder of Lawrence King

    Science.gov (United States)

    Reis, Beth

    2009-01-01

    When Larry King was murdered, allegedly due to a classmate's prejudice, some pundits asked if adults were to blame for encouraging him to come out. They can't be sure what adults did or didn't do, but the question remains: Should adults encourage LGBT [lesbian, gay, bisexual, or transgendered] youth to come out? No. They shouldn't push a young…

  4. Mutual Mate Choice for Colorful Traits in King Penguins

    NARCIS (Netherlands)

    Nolan, Paul M.; Dobson, F. Stephen; Nicolaus, Marion; Karels, Tim J.; McGraw, Kevin J.; Jouventin, Pierre

    2010-01-01

    While studies of mate choice based on male color pattern are ubiquitous, studies of mate choice based on ornamental color traits in sexually monomorphic species are less common. We conducted manipulative field experiments on two color ornaments of king penguins (Aptenodytes patagonicus), the size of

  5. Refining King and Baxter Magolda's Model of Intercultural Maturity

    Science.gov (United States)

    Perez, Rosemary J.; Shim, Woojeong; King, Patricia M.; Baxter Magolda, Marcia B.

    2015-01-01

    This study examined 110 intercultural experiences from 82 students attending six colleges and universities to explore how students' interpretations of their intercultural experiences reflected their developmental capacities for intercultural maturity. Our analysis of students' experiences confirmed as well as refined and expanded King and Baxter…

  6. Ornamental colors reveal age in the king penguin

    NARCIS (Netherlands)

    Nicolaus, Marion; Le Bohec, Celine; Nolan, Paul M.; Gauthier-Clerc, Michel; Le Maho, Yvon; Komdeur, Jan; Jouventin, Pierre

    2007-01-01

    We investigated whether delayed plumage maturation occurred in king penguins (Aptenodytes patagonicus). Therefore we examined the relationships between age and sex on spectral properties and size of two colored plumage patches and a UV-reflective beak spot, using known-age cohorts. Unlike the colore

  7. NEA President Don Morrison Interviews Mrs. Martin Luther King, Jr.

    Science.gov (United States)

    Morrison, Don

    1972-01-01

    Civil rights leader's widow suggests activities conducive to peaceful social change, including Foundation-released film. Describes King Atlanta Center's plans for teacher-training in nonviolent means to attack poverty, fortify women's rights, improve race relations and black representation, end segregation outside South. (PD)

  8. 75 FR 3839 - Martin Luther King, Jr., Federal Holiday, 2010

    Science.gov (United States)

    2010-01-22

    ... promise of economic and social justice because we stand on the shoulders of giants like Dr. King, yet our... ladders of opportunity by correcting social injustice, breaking the cycle of poverty in struggling... strongest weapon against injustice and inequality. Recognizing that our Nation has yet to reach Dr....

  9. Celebrate the legacy of Dr. Martin Luther King Jr.

    OpenAIRE

    Lazenby, Jenna

    2006-01-01

    In celebration of the life and legacy of Dr. Martin Luther King, Jr., Virginia Tech will host a variety of educational and cultural programs and community service events Jan. 14-19, 2007. All events are free and open to the public.

  10. Martin Luther King Jr.: The Crozer Seminary Years.

    Science.gov (United States)

    Carson, Clayborne

    1997-01-01

    As an undergraduate at Morehouse College, Martin Luther King Jr. was not a strong student, although he excelled in oratory, but in his years at Crozer Theological Seminary in Pennsylvania he applied himself to become a straight-A student. The development of his theological perspective is described. (SLD)

  11. A Dr. Martin Luther King, Jr. Curriculum: Playing the Dream.

    Science.gov (United States)

    Clemens, Sydney Gurewitz

    1988-01-01

    Discusses curriculum for young children centered around the beliefs and teachings of Dr. Martin Luther King, Jr. His works are interpreted in a human rights context in which children find their voice in the peaceable resolution of everyday conflicts. Describes the Child of the Day program. (Author/RWB)

  12. Comment on God and Oedipus in Oedipus the King

    Institute of Scientific and Technical Information of China (English)

    龚航

    2009-01-01

    By analyzing the two popular sayings about Oedipus the King on the internet, this paper aims to explore the relationship between God and human being, combined with the artistic theory of Aristotle about the power of a successful drama, and the theme of prophecy, oracles, and predestination.

  13. Making Sense of the Senseless: The Murder of Lawrence King

    Science.gov (United States)

    Reis, Beth

    2009-01-01

    When Larry King was murdered, allegedly due to a classmate's prejudice, some pundits asked if adults were to blame for encouraging him to come out. They can't be sure what adults did or didn't do, but the question remains: Should adults encourage LGBT [lesbian, gay, bisexual, or transgendered] youth to come out? No. They shouldn't push a young…

  14. Identification of the remains of King Richard III

    NARCIS (Netherlands)

    T.E. King (Turi E.); G.G. Fortes (Gloria Gonzalez); P. Balaresque (Patricia); M.G. Thomas (Mark); D.J. Balding (David); P.M. Delser (Pierpaolo Maisano); R. Neumann (Rita); W. Parson (Walther); M. Knapp (Michael); S. Walsh (Susan); L. Tonasso (Laure); J. Holt (John); M.H. Kayser (Manfred); J. Appleby (Jo); P. Forster (Peter); D. Ekserdjian (David); M. Hofreiter (Michael); K. Schürer (Kevin)

    2014-01-01

    textabstractIn 2012, a skeleton was excavated at the presumed site of the Grey Friars friary in Leicester, the last-known resting place of King Richard III. Archaeological, osteological and radiocarbon dating data were consistent with these being his remains. Here we report DNA analyses of both the

  15. 78 FR 59414 - Environmental Impact Statement; King County, Washington

    Science.gov (United States)

    2013-09-26

    ... Federal Highway Administration Environmental Impact Statement; King County, Washington AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of Intent to prepare an environmental impact statement... Environmental Impact Statement (EIS) will be prepared for a proposed project to (1) manage congestion and...

  16. Fat King Penguins Are Less Steady on Their Feet.

    Science.gov (United States)

    Willener, Astrid S T; Handrich, Yves; Halsey, Lewis G; Strike, Siobhán

    2016-01-01

    Returning to the shore after a feeding sojourn at sea, king penguins often undertake a relatively long terrestrial journey to the breeding colony carrying a heavy, mostly frontal, accumulation of fat along with food in the stomach for chick-provisioning. There they must survive a fasting period of up to a month in duration, during which their complete reliance on endogenous energy stores results in a dramatic loss in body mass. Our aim was to determine if the king penguin's walking gait changes with variations in body mass. We investigated this by walking king penguins on a treadmill while instrumented with an acceleration data logger. The stride frequency, dynamic body acceleration (DBA) and posture of fat (pre-fasting; 13.2 kg) and slim (post fasting; 11 kg) king penguins were assessed while they walked at the same speed (1.4 km/h) on a treadmill. Paired statistical tests indicated no evidence for a difference in dynamic body acceleration or stride frequency between the two body masses however there was substantially less variability in both leaning angle and the leaning amplitude of the body when the birds were slimmer. Furthermore, there was some evidence that the slimmer birds exhibited a decrease in waddling amplitude. We suggest the increase in variability of both leaning angle and amplitude, as well as a possibly greater variability in the waddling amplitude, is likely to result from the frontal fat accumulation when the birds are heavier, which may move the centre of mass anteriorly, resulting in a less stable upright posture. This study is the first to use accelerometry to better understand the gait of a species within a specific ecological context: the considerable body mass change exhibited by king penguins.

  17. Human Progress Never Rolls in on Wheels of Inevitability: Biographies of Martin Luther King, Jr., in the Classroom.

    Science.gov (United States)

    Kazemek, Francis E.

    1990-01-01

    Presents resources for teaching about Dr. Martin Luther King, Jr. Outlines criteria for selecting biographies for children and young adults. Identifies problems in certain biographies of King, and recommends high quality biographies of King. Discusses exercises for integrating themes from King's life into the classroom. (RW)

  18. [The oral health problems of Sun King Louis XIV].

    Science.gov (United States)

    Eijkman, M A J

    2012-01-01

    King Louis XIV (1638-1715) of France was a man plagued by a variety of chronic diseases, such as rheumatism, intestinal infections, fistula, headaches, chronic fever, malaria, urinary infections, gout, and chronic oral problems. At his birth, 2 deciduous teeth were already erupted, and at a very young age he already suffered from caries. In 1685, when he revoked the Edict of Nantes, a clumsy extraction of all maxillary teeth gave rise to a large maxillary bone defect and an oroantral communication.

  19. An Analysis Of Theme In Stephen King's Novel The Shining

    OpenAIRE

    Rahmad

    2015-01-01

    Sastra adalah sebuah karangan fiksi dalam bentuk tulisan, dalam tulisan itu menggambarkan masalah yang dialami oleh manusia. Novel adalah salah satu karya sastra yang memiliki unsur intrinsik (unsur dalaman). Mempelajari unsur intrinsik dalam sebuah novel sama dengan mempelajari pengalaman hidup dari sekelompok manusia melalui novel. Penulis menganalisi unsur tema dalam novel berjudul The shining oleh Stephen King 's. Oleh karena itu, Tugas Akhir ini Berjudul: AN ANALYSIS OF THEME IN S...

  20. Pairing Behavior of the Monogamous King Quail, Coturnix chinensis.

    Directory of Open Access Journals (Sweden)

    Elizabeth Adkins-Regan

    Full Text Available Animals with socially monogamous mating systems are valuable for discovering proximate mechanisms of prosocial behavior and close social relationships. Especially powerful are comparisons between related species that differ in monogamous tendency. Birds are the most socially monogamous vertebrates. Thus far most research on mechanisms of pairing has used zebra finches, which do not have a relative with a different mating system, however. The goal of the experiments reported here was to develop a new comparative avian system by studying the pairing behavior of a reportedly strongly monogamous quail, the king quail (Coturnix chinensis, a species in the same clade as the less monogamous Japanese quail (Coturnix japonica, the subject of much prior research. In Experiment 1 male-female pairs of king quail housed together were initially avoidant or aggressive but most rapidly progressed to allopreening and huddling. A separation-reunion paradigm reliably elicited both of these behaviors in males that had cohabited for one week. In Experiment 2 the allopreening and huddling behavior of males in cohabiting pairs was highly selective, and a majority of the males were aggressive toward a familiar female that was not the cohabitation partner. In Experiment 3 males were separated from their female cohabitation partners for 9-10 weeks and then given two-choice tests. All but one male spent more time near an unfamiliar female, which may have reflected aggression and shows recognition of and memory for the past pairing experience. Thus king quail show robust, selective and easy to measure pairing behavior that can be reliably elicited with simple separation-reunion testing procedures. Copulation is rarely seen during tests. The behavior of king quail is a striking contrast to that of Japanese quail, providing a new comparative system for discovering mechanisms of behavior related to close social relationships and monogamy.

  1. The Waste Land in Henderson the Rain King

    Institute of Scientific and Technical Information of China (English)

    童燕芳

    2009-01-01

    As a quest for "out of the waste land",Henderson the Rain King presents a vivid picture of the modem spiritual waste land.The current paper concludes a general view of the waste land by studying Henderson's instinctive feeling and complaint about the world and his life,and also analyzes Henderson's individual case from the perspective of neurotic theory,for his mental crises is rather representative in his time.

  2. Fate or Flaws:On Oedipus the King

    Institute of Scientific and Technical Information of China (English)

    覃思

    2008-01-01

    @@ People usually think that Oedipus in Sophocles'Oedipus the King is the most tragic and innocentprotagonist among all the characters in ancient Greekdramas. Yet, after reading this masterpiece I can' thelp asking: is Oedipus really so desperate that he evendoesn't have a slightest chance to make things right andto avoid that tragedy? Not exactly. Fate, prophesy andhis own flaws together lead the tragic outcome comingstep by step.

  3. Pairing Behavior of the Monogamous King Quail, Coturnix chinensis

    Science.gov (United States)

    Adkins-Regan, Elizabeth

    2016-01-01

    Animals with socially monogamous mating systems are valuable for discovering proximate mechanisms of prosocial behavior and close social relationships. Especially powerful are comparisons between related species that differ in monogamous tendency. Birds are the most socially monogamous vertebrates. Thus far most research on mechanisms of pairing has used zebra finches, which do not have a relative with a different mating system, however. The goal of the experiments reported here was to develop a new comparative avian system by studying the pairing behavior of a reportedly strongly monogamous quail, the king quail (Coturnix chinensis), a species in the same clade as the less monogamous Japanese quail (Coturnix japonica), the subject of much prior research. In Experiment 1 male-female pairs of king quail housed together were initially avoidant or aggressive but most rapidly progressed to allopreening and huddling. A separation-reunion paradigm reliably elicited both of these behaviors in males that had cohabited for one week. In Experiment 2 the allopreening and huddling behavior of males in cohabiting pairs was highly selective, and a majority of the males were aggressive toward a familiar female that was not the cohabitation partner. In Experiment 3 males were separated from their female cohabitation partners for 9–10 weeks and then given two-choice tests. All but one male spent more time near an unfamiliar female, which may have reflected aggression and shows recognition of and memory for the past pairing experience. Thus king quail show robust, selective and easy to measure pairing behavior that can be reliably elicited with simple separation-reunion testing procedures. Copulation is rarely seen during tests. The behavior of king quail is a striking contrast to that of Japanese quail, providing a new comparative system for discovering mechanisms of behavior related to close social relationships and monogamy. PMID:27257681

  4. Toward Inclusive Understandings of Marriage in an Early Childhood Classroom: Negotiating (Un)readiness, Community, and Vulnerability through a Critical Reading of "King and King"

    Science.gov (United States)

    Bentley, Dana Frantz; Souto-Manning, Mariana

    2016-01-01

    This collaborative classroom research study examines the ways in which preschoolers made sense of same-sex marriage through a critical reading of the book "King and King" by De Haan and Nijland. Acknowledging the importance of community in doing critical and political work, this article details the ways in which a preschool teacher and a…

  5. Toward Inclusive Understandings of Marriage in an Early Childhood Classroom: Negotiating (Un)readiness, Community, and Vulnerability through a Critical Reading of "King and King"

    Science.gov (United States)

    Bentley, Dana Frantz; Souto-Manning, Mariana

    2016-01-01

    This collaborative classroom research study examines the ways in which preschoolers made sense of same-sex marriage through a critical reading of the book "King and King" by De Haan and Nijland. Acknowledging the importance of community in doing critical and political work, this article details the ways in which a preschool teacher and a…

  6. The anatomy of the king crab Hapalogaster mertensii Brandt, 1850 (Anomura: Paguroidea: Hapalogastridae): new insights into the evolutionary transformation of hermit crabs into king crabs

    NARCIS (Netherlands)

    Keiler, J.; Richter, S.; Wirkner, C.S.

    2015-01-01

    The emergence of king crabs from a hermit crab-like ancestor is one of the most curious events in decapod evolution. King crabs comprise two taxa, Lithodidae and Hapalogastridae, and while lithodids have formed the focus of various anatomical studies, the internal anatomy of hapalogastrids has never

  7. Pessoa’s myth of the King Sebastian reinterpreted

    Directory of Open Access Journals (Sweden)

    Monika Świda

    2013-01-01

    Full Text Available The present paper depicts alterations undergone by the sleeping king motif (sebastianism in the writings of Fernando Pessoa. The data to conduct the study were collected in thematic anthologies and several unpublished pieces. The myth of the King Sebastian was given a congregational dimension by Pessoa, thus conveying his cultural and identity project subsumed under the metaphor of the spiritual empire. Pessoa introduces some readjustments in the way the historical king is to be conceived of. In his theory, Sebastian becomes the figure of the individual effort on the way towards the national renewal. The messianic character of D. Sebastião is defeated in this theory despite having been associated with the figures of either Jesus or the Antichrist. The messiah of the Portuguese foundation myth is replaced with the idea of great man and the task to be carried out in this field, included the metaphor of the Fifth Empire, gains a cultural character. That is why Pessoa’s theories must no longer be interpreted in messianic terms. The Pessoa’s transformations of the sebastianism analyzed in this article are the starting point for the new national narration in the poetic cycle of "Mensagem".

  8. Ultraviolet reflecting photonic microstructures in the King Penguin beak.

    Science.gov (United States)

    Dresp, Birgitta; Jouventin, Pierre; Langley, Keith

    2005-09-22

    King and emperor penguins (Aptenodytes patagonicus and Aptenodytes forsteri) are the only species of marine birds so far known to reflect ultraviolet (UV) light from their beaks. Unlike humans, most birds perceive UV light and several species communicate using the near UV spectrum. Indeed, UV reflectance in addition to the colour of songbird feathers has been recognized as an important signal when choosing a mate. The king penguin is endowed with several highly coloured ornaments, notably its beak horn and breast and auricular plumage, but only its beak reflects UV, a property considered to influence its sexual attraction. Because no avian UV-reflecting pigments have yet been identified, the origin of such reflections is probably structural. In an attempt to identify the structures that give rise to UV reflectance, we combined reflectance spectrophotometry and morphological analysis by both light and electron microscopy, after experimental removal of surface layers of the beak horn. Here, we characterize for the first time a multilayer reflector photonic microstructure that produces the UV reflections in the king penguin beak.

  9. When the King Becomes your Personal Enemy: W. T. Stead, King Leopold II, and the Congo Free State

    Directory of Open Access Journals (Sweden)

    Marysa Demoor

    2013-04-01

    mso-fareast-language:JA;} This paper will highlight an unknown but important episode in the life of the journalist W. T. Stead, which, intriguingly, remained unmentioned in Belgian, British, and colonial historiography. It concerns a face-to-face meeting between Stead and Leopold II, King of the Belgians, which certainly did not leave Stead the ‘friend of all Kings’, as the posthumous article published by the 'Daily Mirror' contended. Based on Stead’s own Character Sketches in the 'Review of Reviews', the paper will show how Stead’s perceptions of the scandalous government of the Congo Free State result to a large extent from his own meeting (probably towards the end of 1884 with King Leopold II, and the King’s refusal to cooperate with Britain in an improvised rescue of General Gordon in Sudan.

  10. Judas Iscariot: The Archetypal Betrayer and DeMille’s Cine-Biblical Salvation within The King of Kings (1927

    Directory of Open Access Journals (Sweden)

    Anton Karl Kozlovic

    2008-11-01

    Full Text Available Cecil B. DeMille, the legendary cofounder of Hollywood, progenitor of Paramount studio, and unsung Christian auteur was a master of the American biblical epic whose indelible classics became the template for numerous ancient epics thereafter. Utilising humanist film criticism as the guiding analytical lens, the critical DeMille, film and religion literature was selectively reviewed and his silent Jesus film, The King of Kings (1927 was closely examined to reveal his dramatic construction of Judas Iscariot, which was briefly compared to some cinematic rivals to highlight its frequent superiority. Often unappreciated was DeMille’s harmonisation of the conflicting hanging versus disembowelment accounts of Judas’ demise. It was concluded that DeMille was a defter biblical filmmaker than has been hitherto appreciated. Further research into DeMille studies, Hollywood epics, and the emerging interdisciplinary field of religion-and-film is recommended, warranted, and already long overdue.

  11. Three Kings and the Bright Star of Fame

    Directory of Open Access Journals (Sweden)

    Emalyn J. Bullis

    2013-12-01

    Full Text Available Many phenomena in music history as well as in American history have helped develop and shape the types of music listened to today, but none have been so fresh as looking back to twentieth-century popular music and the several key individuals that “ruled” in this area. These “rulers” were hailed as “kings” firstly as a media ploy, but the American public did nothing but encourage the titles. This is somewhat confusing considering American’s pride in their democratic political system but history shows that in several key American cultural changes the “Kings” crowned in the music sphere are representative of these changes. While not difficult to determine who these individuals are, as most of them were hailed and recognized as “Kings” to their respective audiences. Benny Goodman, the King of Swing, in the 1920’s and 30’s helped usher in and popularize the Swing movement. Elvis Presley, the King of Rock and Roll, capitalized (intentionally or not on the move towards combining African-American sounds such as blues and jazz with folk, gospel, and soul, thus creating a whole new and extremely popular sound. Michael Jackson, the King of Pop, was practically born into fame with his involvement with the ‘Jackson 5,’ but that did not stop him from rising up the ladder of fame in his solo career to change the face of pop music forever. There were also many artists that surrounded these “kings,” a court, if you will, that allowed their new styles to proliferate throughout American culture, and sometimes even surpassed them musically. However, as icons, these men stand on their own for their achievements in music and their ability to change and adapt to the culture around them. By looking at the three Kings of American pop culture’s past, it is possible to see the direction of America’s culture in general from the 1920’s on and perhaps see the trajectory of music of the USA today

  12. A Discourse Analysis of the Centered and Critical Scholar-Activism of Martin Luther King Jr.

    OpenAIRE

    Keatts, Quenton

    2010-01-01

    The purpose of this project is to investigate the often neglected research concerning the Reverend Dr. Martin Luther King, Jr. and his scholar-activism. This project is intended to look for evidence of intellectual leadership within Kingâ s writings in an effort to classify King within the Scholar-Activist paradigm in Africana Studies. Further, the aim is to examine Martin Luther King, Jr. from the critical and centered Scholar-Activist paradigm of Africana Studies based on an analysis of ...

  13. King penguin population threatened by Southern Ocean warming.

    Science.gov (United States)

    Le Bohec, Céline; Durant, Joël M; Gauthier-Clerc, Michel; Stenseth, Nils C; Park, Young-Hyang; Pradel, Roger; Grémillet, David; Gendner, Jean-Paul; Le Maho, Yvon

    2008-02-19

    Seabirds are sensitive indicators of changes in marine ecosystems and might integrate and/or amplify the effects of climate forcing on lower levels in food chains. Current knowledge on the impact of climate changes on penguins is primarily based on Antarctic birds identified by using flipper bands. Although flipper bands have helped to answer many questions about penguin biology, they were shown in some penguin species to have a detrimental effect. Here, we present for a Subantarctic species, king penguin (Aptenodytes patagonicus), reliable results on the effect of climate on survival and breeding based on unbanded birds but instead marked by subcutaneous electronic tags. We show that warm events negatively affect both breeding success and adult survival of this seabird. However, the observed effect is complex because it affects penguins at several spatio/temporal levels. Breeding reveals an immediate response to forcing during warm phases of El Niño Southern Oscillation affecting food availability close to the colony. Conversely, adult survival decreases with a remote sea-surface temperature forcing (i.e., a 2-year lag warming taking place at the northern boundary of pack ice, their winter foraging place). We suggest that this time lag may be explained by the delay between the recruitment and abundance of their prey, adjusted to the particular 1-year breeding cycle of the king penguin. The derived population dynamic model suggests a 9% decline in adult survival for a 0.26 degrees C warming. Our findings suggest that king penguin populations are at heavy extinction risk under the current global warming predictions.

  14. Paleomagnetism of King George Island, South Shetlands, Antarctica

    Science.gov (United States)

    Slotznick, S. P.; Kirschvink, J. L.; Raub, T. D.; Swanson-Hysell, N.; Edgar, L.

    2011-12-01

    During December of 2009 when the US R/V Lawrence M. Gould was iced out of the Antarctic Peninsula, we collected core and block samples from 17 different flows and dikes at three sampling areas on Weaver Peninsula and Fildes Peninsula, King George Island, South Shetland Islands, Antarctica. Two of the three sampling areas on Weaver Peninsula and Fildes Peninsula were near dikes with Ar-Ar ages of 54.6 ± 3.8 Ma and 57.4 ± 2.1 Ma respectively, close in age to the Paleocene Eocene Thermal Maximum (PETM) (Kraus 2005, Kraus et al. 2007). After removal of significant magnetically soft components by low-temperature cycling and weak AF demagnetization, the basaltic flows from the Weaver Peninsula preserve a dual-polarity characteristic remanence isolated by higher-field AF demagnetization with an in-situ magnetization of D = 166.3, I= 65.4 (n/N = 24/30, α95 = 6.31). This direction, prior to correction for bedding tilt, is indistinct from a plausible Cenozoic reversed polarity magnetization for the site, while correcting for bedding tilt results in anomalously shallow inclinations. This result implies a post-tilting thermochemical remagnetization origin for the characteristic remanence. Analyses of the baked contact, dikes, and conglomerate tests help constrain the age of this event in context of subsequent Cenozoic magmatism on King George Island. Rock magnetic and Kappabridge experiments show that the magnetic mineralogy of the samples is often dominated by magnetite, with titanomagnetite and hematite present in some flows. The results of this multi-site study of Weaver and Fildes Peninsulas add to a growing paleomagnetic database for volcanic rocks from King George Island (Valencio et al. 1979, Kraus et al. 2010, Watts et al. 1984, Nawrocki et al. 2010) and contribute to a better understanding of the complex tectonic and magmatic activity of the South Shetland Islands.

  15. Outliers and Extremes: Dragon-Kings or Dragon-Fools?

    Science.gov (United States)

    Schertzer, D. J.; Tchiguirinskaia, I.; Lovejoy, S.

    2012-12-01

    Geophysics seems full of monsters like Victor Hugo's Court of Miracles and monstrous extremes have been statistically considered as outliers with respect to more normal events. However, a characteristic magnitude separating abnormal events from normal ones would be at odd with the generic scaling behaviour of nonlinear systems, contrary to "fat tailed" probability distributions and self-organized criticality. More precisely, it can be shown [1] how the apparent monsters could be mere manifestations of a singular measure mishandled as a regular measure. Monstrous fluctuations are the rule, not outliers and they are more frequent than usually thought up to the point that (theoretical) statistical moments can easily be infinite. The empirical estimates of the latter are erratic and diverge with sample size. The corresponding physics is that intense small scale events cannot be smoothed out by upscaling. However, based on a few examples, it has also been argued [2] that one should consider "genuine" outliers of fat tailed distributions so monstrous that they can be called "dragon-kings". We critically analyse these arguments, e.g. finite sample size and statistical estimates of the largest events, multifractal phase transition vs. more classical phase transition. We emphasize the fact that dragon-kings are not needed in order that the largest events become predictable. This is rather reminiscent of the Feast of Fools picturesquely described by Victor Hugo. [1] D. Schertzer, I. Tchiguirinskaia, S. Lovejoy et P. Hubert (2010): No monsters, no miracles: in nonlinear sciences hydrology is not an outlier! Hydrological Sciences Journal, 55 (6) 965 - 979. [2] D. Sornette (2009): Dragon-Kings, Black Swans and the Prediction of Crises. International Journal of Terraspace Science and Engineering 1(3), 1-17.

  16. Fish for peasants and kings - a Danish perspective

    DEFF Research Database (Denmark)

    Kristiansen, Mette Svart

    2011-01-01

    Fish played an important role in medieval Europe. It formed the basis of a food culture influenced by Catholicism and was a central commodity in the national and international network of trade. Fish of all sorts held a prominent position on the dining tables of peasants as well as kings. Household...... commodity at the international market. The cheap herring from the local markets in the Limfjord supplied the national as well as the international market in the spring in a period with poor food supply generally. Also substantial was the North Sea fishing on herring, whiting and flatfish off the west coast...

  17. Pleistocene glaciation of the King Valley, Western Tasmania, Australia

    Science.gov (United States)

    Fitzsimons, Sean J.; Colhoun, Eric A.

    1991-09-01

    Analysis of the geomorphology, geology, and palynology of deposits in the King Valley permits the identification of four glaciations and two interglaciations and has led to a revision of the Pleistocene stratigraphy of the West Coast Range. The oldest late-Cenozoic deposits in the valley appear to predate glaciation, contain extinct pollen types, and are probably of late-Tertiary age. Overlying deposits of the Linda Glaciation show intense chemical weathering and have a reversed detrital remanent magnetization indicating deposition before 730,000 yr B.P. The highly weathered tills are conformably overlain by organic deposits of the Regency Interglaciation which show a transition from montane scrub rainforest to lowland temperate rainforest. Deposits formed during the later Moore Glaciation record advances of the King Glacier and glaciers from the West Coast Range. A pollen-bearing fluvial deposit records an interstade during this glaciation. On the basis of weathering rinds, amino acid dating, and palaeomagnetism the deposits are estimated to have formed between 730,000 and 390,000 yr B.P. The Moore Glaciation deposits are overlain by sediments of the Henty Glaciation which are believed to predate 130,000 yr B.P. These deposits record multiple advances of the King Glacier and the development of a large lake during an interstade. Deposits of the subsequent Pieman Interglaciation consist of organic fine sands and silts that record a lowland scrub rainforest. Deposits of the last (Margaret) glaciation are restricted to small areas in the northern part of the valley. Although the most recent ice advance culminated after 19,000 yr B.P., evidence of older deposits of the Margaret Glaciation suggests that an early last-glaciation ice advance may have occurred. When combined with earlier studies, the recent work in the King Valley has provided one of the more complete records of Pleistocene glaciation in the Southern Hemisphere. Comparison of the deposits with the record

  18. Martin Luther King, Jr., General Hospital and community involvement.

    Science.gov (United States)

    Humphrey, M M

    1973-07-01

    Community involvement is not just one facet of the new Martin Luther King, Jr., General Hospital's existence. It is the mainstream from which all other activities flow. In addition to meeting the conventional needs of a conventional hospital staff with the core collection of texts and journals, this library goes one step further. It acts as a resource for its community health workers, dietitians, and nurses in their various outreach programs. It serves as a stimulus for the high school or community college student who may be curious about a health career. It also finds time to provide reading material for its patients.

  19. Missions of Patriotism: Joseph H. Jackson and Martin Luther King

    Directory of Open Access Journals (Sweden)

    Sam Hitchmough

    2011-06-01

    Full Text Available I.IntroductionJoseph H. Jackson has been treated very negatively in history-writing. Most texts refer to him in passing as the “brilliantly conservative”, “autocratic” president of the National Baptist Convention, a figure opposed to the Civil Rights Movement or else a man with a personal grudge or a neurotic dislike of Martin Luther King. King’s deputy, Ralph Abernathy, speculates that it may have been a “certain amount of envy” that caused Jackson to ‘turn’ on the movement. The bitter feud...

  20. A Study of Forms and Linguistic Usage of Meeting Documents in the Reign of His Majesty King Chulalongkorn and the Reign of His Majesty King Bhumibol Adulyadej

    Directory of Open Access Journals (Sweden)

    Preeya Hiranpradit

    2010-01-01

    Full Text Available Problem statement: At present, meeting is an activity which is necessary for work. Gathering for discussing or solving problems is assumed that it has been held since the reign of His Majesty King Chulalongkorn. The purposes of this research were these: (1 to investigate forms of meeting documents in the reign of His Majesty King Chulalongkorn and the reign of His Majesty King Bhumibol Adulyadej, (2 to analyses meeting procedures from the minutes of the meetings in the reign of His Majesty King Chulalongkorn and the reign of His Majesty King Bhumibol Adulyadej and (3 to analyses Thai usage in the minutes of the meetings in the reign of His Majesty King Chulalongkorn and the reign of His Majesty King Bhumibol Adulyadej. Approach: The meeting documents in the reign of His Majesty King Chalalongkorn such as microfilms and four books of script photos were analyzed, they consisted of four meeting document: (1 the minutes of the meeting of the Minister Council in the first session on the Council of State Affairs Councilor, (2 the minute of the meeting of the Minister Council in Rattanakosin Era of 111, (3 the minute of the meeting of the Minister Council in the second session, part one in Rattanakosin Era of 112 and (4 the minutes of the meeting of the Minister Council in the third session in Rattanakosin Era of 113. A total pages of these documents was 1,000 pages. A sample was 6 experts I creating meeting documents and 1 linguistic expert. Research data were collected by means of an interview, the data were analyzed by means of an interpretation and a composition technique and were presented by means of a descriptive analysis. Results: (1 Forms of meeting documents in the reign of His Majesty King Chulalongkorn and His Majesty King Bhumibol Adulyadej consisted of these: (i A law of meeting regulations, (ii a document of meeting schedule and agenda, (iii the minutes of the meeting, (iv a meeting document and (v an after

  1. AFSC/RACE/SAP/Long: Data from: Habitat, predation, growth, and coexistence: Could interactions between juvenile red and blue king crabs limit blue king crab productivity?

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is from a series of laboratory experiments examining the interactions between red and blue king crabs and habitat. We examined how density and predator...

  2. Eocene paleosols of King George Island, Maritime Antarctica

    Science.gov (United States)

    Spinola, Diogo; Portes, Raquel; Schaefer, Carlos; Kühn, Peter

    2016-04-01

    Red layers between lava flows on King George Island, Maritime Antarctica, were formed during the Eocene, which was one of the warmest periods on Earth in the Cenozoic. Our hypothesis is that these red layers are paleosols formed in periods of little or no volcanic activity. Therefore, our main objective was to identify the main pedogenic properties and features to distinguish these from diagenetic features formed after the lava emplacement. Additionally, we compared our results with volcanic soils formed under different climates to find the best present analogue. The macromorphological features indicate a pedogenic origin, because of the occurrence of well-defined horizons based on colour and structure. Micromorphological analyses showed that most important pedogenic features are the presence of biological channels, plant residues, anisotropic b-fabric, neoformed and illuvial clay and distinct soil microstructure. Although the paleosols are not strongly weathered, the geochemical data also support the pedogenic origin despite of diagenetic features as the partial induration of the profiles and zeolites filling nearly all voids in the horizons in contact with the overlying lava flow, indicating circulation of hydrothermal fluids. The macromorphological and micromorphological features of these paleosols are similar to the soils formed under seasonal climates. Thus, these paleosol features do not correspond to the other proxies (e.g. sediment, plant fossils), which indicate a wet, non-seasonal climate, as in Valdivian Forest, Chile, during the Eocene in King George Island

  3. King County Metro Battery Electric Bus Demonstration: Preliminary Project Results

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-22

    The U.S. Federal Transit Administration (FTA) funds a variety of research projects that support the commercialization of zero-emission bus technology. To evaluate projects funded through these programs, FTA has enlisted the help of the National Renewable Energy Laboratory (NREL) to conduct third-party evaluations of the technologies deployed under the FTA programs. NREL works with the selected agencies to evaluate the performance of the zero-emission buses compared to baseline conventional buses in similar service. The evaluation effort will advance the knowledge base of zero-emission technologies in transit bus applications and provide 'lessons learned' to aid other fleets in incrementally introducing next generation zero-emission buses into their operations. This report provides preliminary performance evaluation results from a demonstration of three zero-emission battery electric buses at King County Metro in King County, Washington. NREL developed this preliminary results report to quickly disseminate evaluation results to stakeholders. Detailed evaluation results will be published in future reports.

  4. The Greek charter of the Hungarian King Stephen I

    Directory of Open Access Journals (Sweden)

    Stojkovski Boris

    2016-01-01

    Full Text Available The first Hungarian Christian ruler, King Stephen I (997-1038 issued several charters that have survived to this day. One of them is the charter issued on behalf of the nuns from the Monastery of the Holy Theotokos in Veszprémvölgy. The charter was written in the Greek language, and has been the subject of many studies. The original has not been preserved; what remains is a copy from the time of King Coloman, dated to 1109. The charter has not been published in a critical edition in any language other than Hungarian and even though it has been examined by numerous Hungarian scholars, many questions remain open. The aim of the author is to provide a critical edition and an English translation of the charter, but also to clarify some remaining doubts about the charter and its contents. Furthermore, some comparisons will be made with the Byzantine charters issued at the beginning of the 11th and during the 12th century.

  5. BOREAS AFM-2 Wyoming King Air 1994 Aircraft Sounding Data

    Science.gov (United States)

    Kelly, Robert D.; Hall, Forrest G. (Editor); Knapp, David E. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    The BOREAS AFM-2 team used the University of Wyoming King Air aircraft during IFCs 1, 2, and 3 in 1994 to collected pass-by-pass fluxes (and many other statistics) for the large number of level (constant altitude), straight-line passes used in a variety of flight patterns over the SSA and NSA and areas along the transect between these study areas. The data described here form a second set, namely soundings that were incorporated into nearly every research flight by the King Air in 1994. These soundings generally went from near the surface to above the inversion layer. Most were flown immediately after takeoff or immediately after finishing the last flux pattern of that particular day's flights. The parameters that were measured include wind direction, wind speed, west wind component (u), south wind component (v), static pressure, air dry bulb temperature, potential temperature, dewpoint, temperature, water vapor mixing ratio, and CO2 concentration. Data on the aircraft's location, attitude, and altitude during data collection are also provided. These data are stored in tabular ASCH files. The data files are available on a CD-ROM (see document number 20010000884) or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  6. The King James Bible and the Politics of Religious Education: Secular State and Sacred Scripture

    Science.gov (United States)

    Gearon, Liam

    2013-01-01

    This article provides an outline historical-educational analysis of the King James Bible from its 1611 publication through to its four-hundredth anniversary commemoration in 2011. With particular focus on England, the article traces the educational impact of the King James Bible and charts, in the country of its origin, its progressive decline in…

  7. The "Other" Beauty of Martin Luther King, Jr.'s "Letter from Birmingham Jail."

    Science.gov (United States)

    Klein, Mia

    1981-01-01

    Submits that Martin Luther King's persuasiveness in his writings may be attributed not only to his structure, logic, and ethos, but even more to his creative, eloquent, and commanding use of the English language. Supports this argument with examples from King's "Letter from Birmingham Jail." (RL)

  8. Reading Stephen King: Issues of Censorship, Student Choice, and Popular Literature.

    Science.gov (United States)

    Power, Brenda Miller, Ed.; Wilhelm, Jeffrey D., Ed.; Chandler, Kelly, Ed.

    This collection of essays grew out of the "Reading Stephen King Conference" held at the University of Maine in 1996. Stephen King's books have become a lightning rod for the tensions around issues of including "mass market" popular literature in middle and high school English classes and of who chooses what students read.…

  9. William Bennett on Martin Luther King: Mock-Diversifying the Core Curriculum.

    Science.gov (United States)

    Zorn, Jeff

    1992-01-01

    The writings of Martin Luther King Jr. deserve to be read in undergraduate humanities classes but not in the spirit advocated by former Secretary of Education William Bennett. It is argued that Bennett downplays the struggles against racial discrimination and chooses the most conservative King pieces for the literary canon. (SLD)

  10. Range-wide wetland associations of the King Rail: A multi-scale approach

    Science.gov (United States)

    Glisson, Wesley J.; Conway, Courtney J.; Nadeau, Christopher P.; Borgmann, Kathi L.; Laxson, Thomas A.

    2015-01-01

    King Rail populations have declined and identifying wetland features that influence King Rail occupancy can help prevent further population declines. We integrated continent-wide marsh bird survey data with spatial wetland data from the National Wetland Inventory (NWI) to examine wetland features that influenced King Rail occupancy throughout the species’ range. We analyzed wetland data at 7 spatial scales to examine the scale(s) at which 68 wetland features were most strongly related to King Rail occupancy. Occupancy was most strongly associated with estuarine features and brackish and tidal saltwater regimes. King Rail occupancy was positively associated with emergent and scrub-shrub wetlands and negatively associated with forested wetlands. The best spatial scale for assessing King Rail occupancy differed among wetland features; we could not identify one spatial scale (among all wetland features) that best explained variation in occupancy. Future research on King Rail habitat that includes multiple spatial scales is more likely to identify the suite of features that influence occupancy. Our results indicate that NWI data may be useful for predicting occupancy based on broad habitat features across the King Rail’s range, which may help inform management decisions for this and other wetland-dependent birds.

  11. 82 FR 39535 - Safety Zone: PG&E Evolution, King Salmon, CA

    Science.gov (United States)

    2017-08-21

    ...-AA00 Safety Zone: PG&E Evolution, King Salmon, CA AGENCY: Coast Guard, DHS. ACTION: Temporary final... Humboldt Bay in King Salmon, CA in support of the Pacific Gas and Electric Evolution that will be effective... workers, mariners, and other vessels transiting the area from the dangers associated with this evolution...

  12. Addressing Curriculum Deficiencies on Martin Luther King, Jr. through Computer Assisted Instruction and Multimedia Resources.

    Science.gov (United States)

    Kim, James S.

    Students need to see past heroes as real people who struggled with ordinary problems in order to see the relevancy of studying history and to act practically upon the lessons that each leader teaches them. This study attempts to answer two questions relating to Martin Luther King, Jr.: (1) What do we teach our children about King? and (2) Can we…

  13. Difficulties in Academic Writing: From the Perspective of King Saud University Postgraduate Students

    Science.gov (United States)

    Al Fadda, Hind

    2012-01-01

    The purpose of this study was to determine what difficulties King Saud University students encounter when learning to write academic English and to differentiate between students' learning needs and objectives. The sample consisted of 50 postgraduate students enrolled in King Saud University during the academic year 2009-2010. Analysis of the data…

  14. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    Science.gov (United States)

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  15. Martin Luther King, Jr. and the Power of Nonviolence. [Lesson Plan].

    Science.gov (United States)

    National Endowment for the Humanities (NFAH), Washington, DC.

    This lesson plan introduces students in grades 6-8 to Martin Luther King Jr.'s philosophy of nonviolence and the teachings of Mohandas K. Gandhi that influenced King's views. After considering the political impact of this philosophy, students explore its relevance to personal life. In these 6 lessons students will: (1) examine the philosophy of…

  16. Martin Luther King, Jr. Borrows a Revolution: Argument, Audience, and Implications of a Secondhand Universe.

    Science.gov (United States)

    Miller, Keith D.

    1986-01-01

    Examines features of and sources for the discourse of Martin Luther King, Jr., as they relate to the language and assumptions favored by his listeners and readers in an effort to understand how speakers and writers can successfully argue from premises that audiences accept. Indicates how an understanding of King can help in composition…

  17. Children's Books on Martin Luther King, Jr. Offer a One-Dimensional View.

    Science.gov (United States)

    Banfield, Beryle

    1985-01-01

    Reviews children's books, teacher references, mini-plays, and curriculum resources that relate to the life of Martin Luther King, Jr. Reports that most of these sources ignore growth and changes within King's life and thought, the role models who shaped his philosophy, or his participation in issues such as the Vietnam War and poverty. (KH)

  18. 75 FR 57478 - Accreditation and Approval of King Laboratories, Inc., as a Commercial Gauger and Laboratory

    Science.gov (United States)

    2010-09-21

    ... SECURITY U.S. Customs and Border Protection Accreditation and Approval of King Laboratories, Inc., as a Commercial Gauger and Laboratory AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of King Laboratories, Inc., as a commercial gauger...

  19. 75 FR 3245 - Accreditation and Approval of King Laboratories, Inc., as a Commercial Gauger and Laboratory

    Science.gov (United States)

    2010-01-20

    ... SECURITY U.S. Customs and Border Protection Accreditation and Approval of King Laboratories, Inc., as a Commercial Gauger and Laboratory AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of King Laboratories, Inc., as a commercial gauger...

  20. 78 FR 6828 - Accreditation and Approval of King Laboratories, Inc., as a Commercial Gauger and Laboratory

    Science.gov (United States)

    2013-01-31

    ... SECURITY U.S. Customs and Border Protection Accreditation and Approval of King Laboratories, Inc., as a Commercial Gauger and Laboratory AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of King Laboratories, Inc., as a commercial gauger...

  1. Martin Luther King Family Center, Chicago, Illinois: Model Programs. Childhood Education.

    Science.gov (United States)

    American Institutes for Research in the Behavioral Sciences, Palo Alto, CA.

    Prepared for the White House Conference on Children (December 1970), this booklet reports on the Martin Luther King Family Center, one of 34 promising programs on childhood education. The Martin Luther King Family Center is now a privately funded, community-controlled demonstration service center with an all black staff. All of its programs are…

  2. 76 FR 5326 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; King and Spanish Mackerel Coastal...

    Science.gov (United States)

    2011-01-31

    ..., Gulf of Mexico, and South Atlantic; King and Spanish Mackerel Coastal Migratory Pelagic Fishery Off the... future access to the king and Spanish mackerel components of the coastal migratory pelagics fishery..., the Council recommended a new control date of September 17, 2010, for king and Spanish mackerel....

  3. King-Denborough Syndrome: report of two Brazilian cases

    Directory of Open Access Journals (Sweden)

    Reed Umbertina Conti

    2002-01-01

    Full Text Available We report on two boys aged 2 and 6 years-old respectively with dysmorphic face, ptosis, down-slanting palpebral fissures, hypertelorism, epicanthic folds, low-set ears, malar hypoplasia, micrognathia, high-arched palate, clinodactyly, palmar simian line, pectus excavatum, winging of the scapulae, lumbar lordosis and mild thoracic scoliosis who present congenital hypotonia, slightly delayed motor development, diffuse joint hyperextensibility and mild proximal weakness. The muscle biopsy revealed minimal but identifiable changes represented by size fiber variability, type I fiber predominance and atrophy, perimysial fibrous infiltration and some disarray of the intermyofibrillary network. These cases correspond to the first Brazilian reports of the King-Denborough syndrome and our objective is increasing the awareness of this disorder as these patients are predisposed to developing malignant hyperthermia.

  4. Biological Activities and Phytochemicals of Swietenia macrophylla King

    Directory of Open Access Journals (Sweden)

    Habsah Abdul Kadir

    2013-08-01

    Full Text Available Swietenia macrophylla King (Meliaceae is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals that limonoids and its derivatives are the major constituents of S. macrophylla. There are several data in the literature indicating a great variety of pharmacological activities of S. macrophylla, which exhibits antimicrobial, anti-inflammatory, antioxidant effects, antimutagenic, anticancer, antitumor and antidiabetic activities. Various other activities like anti-nociceptive, hypolipidemic, antidiarrhoeal, anti-infective, antiviral, antimalarial, acaricidal, antifeedant and heavy metal phytoremediation activity have also been reported. In view of the immense medicinal importance of S. macrophylla, this review aimed at compiling all currently available information on its ethnomedicinal uses, phytochemistry and biological activities of S. macrophylla, showing its importance.

  5. Volcanic geology of Admiralty Bay, King George Island, Antarctica

    Institute of Scientific and Technical Information of China (English)

    邢光福; 王德滋; 金庆民; 沈渭洲; 陶奎元

    2002-01-01

    At Admiralty Bay of central King George Island, Keller Peninsula, Ullman Spur and Point Hennequin are main Tertiary volcanic terranes. Field investigation and isotopic datings indicate that, there occurred three periods of eruptions ( three volcanic cycles) and accompanying N-toward migration of the volcanic center on Keller Peninsula. After the second period of eruptions, the crater collapsed and a caldera was formed, then later eruptions were limited at the northern end of the peninsula and finally migrated to Ullman Spur. Thus Keller Peninsula is a revived caldera, and its volcanism migrated toward E with time. Point Hennequin volcanism happened more or less simultaneously with the above two areas, but has no clear relation in chemical evolution with them, frequently it belongs to another independent volcanic center.

  6. INSIGHT AGONISTES: A READING OF SOPHOCLES'S OEDIPUS THE KING.

    Science.gov (United States)

    Mahon, Eugene J

    2015-07-01

    In this reading of Sophocles's Oedipus the King, the author suggests that insight can be thought of as the main protagonist of the tragedy. He personifies this depiction of insight, calling it Insight Agonistes, as if it were the sole conflicted character on the stage, albeit masquerading at times as several other characters, including gods, sphinxes, and oracles. This psychoanalytic reading of the text lends itself to an analogy between psychoanalytic process and Sophocles's tragic hero. The author views insight as always transgressing against, always at war with a conservative, societal, or intrapsychic chorus of structured elements. A clinical vignette is presented to illustrate this view of insight. © 2015 The Psychoanalytic Quarterly, Inc.

  7. [Oceanography and King Dom Carlos I's collection of iconography].

    Science.gov (United States)

    Jardim, Maria Estela; Peres, Isabel Marília; Ré, Pedro Barcia; Costa, Fernanda Madalena

    2014-01-01

    After the Challenger expedition (1872-1878), other nations started to show interest in oceanographic research and organizing their own expeditions. As of 1885, Prince Albert I of Monaco conducted oceanographic campaigns with the collaboration of some of the best marine biologists and physical oceanographers of the day, inventing new techniques and instruments for the oceanographic work. Prince Albert's scientific activity certainly helped kindle the interest of his friend, Dom Carlos I, king of Portugal, in the study of the oceans and marine life. Both shared the need to use photography to document their studies. This article analyzes the role of scientific photography in oceanography, especially in the expeditions organized by the Portuguese monarch.

  8. Medical students’ assessment preferences at King Faisal University, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Tarek Tawfik Amin

    2011-03-01

    Full Text Available Tarek Tawfik Amin1, Feroze Kaliyadan2, Nouria Saab Al-Muhaidib31Community Medicine Department, Faculty of Medicine, Cairo, Egypt; 2Department of Internal Medicine, Dermatology Section; 3Vice Dean for Female Students, College of Medicine, King Faisal University, Saudi ArabiaObjective: To assess the preferred methods for assessment among medical students at both preclinical and clinical stages of medical education and the possible correlates that promote these preferences.Subjects and methods: All medical students from the third year onwards were surveyed. A self-administered anonymous questionnaire was designed to gather information on the preferred assessment method for course achievement. The preferred methods were also evaluated in relation to cognitive functions. Preference for specific exam format, in the form of multiple choices, short essay questions, or both, and the stated reasons for that preference, was also included in the questionnaire.Results: Out of 310 questionnaires distributed, 238 were returned. Written tests, projects, portfolios, and take home exams were the preferred modes for assessing students’achievements in a course; oral tests including a viva voce were the least preferred type of assessment. Questions that tested the domains of ‘understanding’ and ‘application’ were the most preferred type while those entailing ‘analysis’ were the least preferred. Multiple choice question format was the most preferred type of question (68.7% at both pre- and clinical stages.Conclusion: Students’ assessments at the College of Medicine, King Faisal University, Saudi Arabia, do not use the full range of cognitive domains. The emphasis on higher domains for medical students’ assessment incorporating critical thinking should increase as the students’ progress through their medical courses.Keywords: medical students, assessment, exams, multiple choices, essay

  9. Glucose regulates lipid metabolism in fasting king penguins.

    Science.gov (United States)

    Bernard, Servane F; Orvoine, Jord; Groscolas, René

    2003-08-01

    This study aims to determine whether glucose intervenes in the regulation of lipid metabolism in long-term fasting birds, using the king penguin as an animal model. Changes in the plasma concentration of various metabolites and hormones, and in lipolytic fluxes as determined by continuous infusion of [2-3H]glycerol and [1-14C]palmitate, were examined in vivo before, during, and after a 2-h glucose infusion under field conditions. All the birds were in the phase II fasting status (large fat stores, protein sparing) but differed by their metabolic and hormonal statuses, being either nonstressed (NSB; n = 5) or stressed (SB; n = 5). In both groups, glucose infusion at 5 mg.kg-1.min-1 induced a twofold increase in glycemia. In NSB, glucose had no effect on lipolysis (maintenance of plasma concentrations and rates of appearance of glycerol and nonesterified fatty acids) and no effect on the plasma concentrations of triacylglycerols (TAG), glucagon, insulin, or corticosterone. However, it limited fatty acid (FA) oxidation, as indicated by a 25% decrease in the plasma level of beta-hydroxybutyrate (beta-OHB). In SB, glucose infusion induced an approximately 2.5-fold decrease in lipolytic fluxes and a large decrease in FA oxidation, as reflected by a 64% decrease in the plasma concentration of beta-OHB. There were also a 35% decrease in plasma TAG, a 6.5- and 2.8-fold decrease in plasma glucagon and corticosterone, respectively, and a threefold increase in insulinemia. These data show that in fasting king penguins, glucose regulates lipid metabolism (inhibition of lipolysis and/or of FA oxidation) and affects hormonal status differently in stressed vs. nonstressed individuals. The results also suggest that in birds, as in humans, the availability of glucose, not of FA, is an important determinant of the substrate mix (glucose vs. FA) that is oxidized for energy production.

  10. The philosophical premises of the second King Report on corporate governance

    Directory of Open Access Journals (Sweden)

    G.J. Rossouw

    2005-07-01

    Full Text Available This article focuses on the philosophical presuppositions of the second King Report on corporate governance for South Africa (hereafter referred to as the King II Report. Especially in the “Introduction and Background” section of the King II Report it is clear that the Report is premised upon a specific understanding of the present-day corporation and its moral obligations. The purpose of this article is to commit what Charles Taylor called “an act of retrieval” in which the philosophical premises of the King II Report will be unearthed and exposed. It will be argued that the view of the present-day corporation that underlies the King II Report could be related back to a number of debates on the notion of the comtemporary corporation and its moral responsibilities that have been played out since the 1970s. It will be indicated how these debates provide the philosophical foundations for the view of the comtemporary corporation and its moral obligations that is espoused in the King II Report. The claim made in the Report that the African world view and culture influenced the Report’s notion of corporate governance will also be critically reviewed. Finally it will be attempted to evaluate to what extent the recommendations of the King II Report live up to its own philosophical premises.

  11. Brood rearing ecology of king eiders on the north slope of Alaska

    Science.gov (United States)

    Phillips, Laura M.; Powell, Abby N.

    2009-01-01

    We examined King Eider (Somateria spectabilis) brood survival in the Kuparak oil field in northern Alaska in 2002 and 2003 by monitoring hens with broods using radiotelemetry. We observed complete brood loss in eight of 10 broods. Broods survived less than 2 weeks on average, and most mortality occurred within 10 days of hatch. Distance hens traveled overland did not affect brood survival. Apparent King Eider brood survival in our study area was lower than reported for eider species in other areas. We recommend future studies examine if higher densities of predators in oil fields reduces King Eider duckling survival.

  12. Synchronization and an application of a novel fractional order King Cobra chaotic system.

    Science.gov (United States)

    Muthukumar, P; Balasubramaniam, P; Ratnavelu, K

    2014-09-01

    In this paper, we design a new three dimensional King Cobra face shaped fractional order chaotic system. The multi-scale synchronization scheme of two fractional order chaotic systems is described. The necessary conditions for the multi-scale synchronization of two identical fractional order King Cobra chaotic systems are derived through feedback control. A new cryptosystem is proposed for an image encryption and decryption by using synchronized fractional order King Cobra chaotic systems with the supports of multiple cryptographic assumptions. The security of the proposed cryptosystem is analyzed by the well known algebraic attacks. Numerical simulations are given to show the effectiveness of the proposed theoretical results.

  13. No barrier to emergence of bathyal king crabs on the Antarctic shelf

    DEFF Research Database (Denmark)

    Aronson, Richard B.; Smith, Kathryn E.; Vos, Stephanie C.;

    2015-01-01

    showed that abundant, predatory king crabs comprise a reproductively viable population at 841- to 2,266-m depth. Depth profiles of temperature, salinity, habitat structure, food availability, and predators indicate that there are no barriers to prevent king crabs from moving upward onto the outer shelf...... at 400–550 m. A cold-water barrier above 200 m could be breached within the next few decades. Emergence of king crabs on the shelf could have catastrophic consequences for the unique seafloor communities of Antarctica....

  14. Synchronization and an application of a novel fractional order King Cobra chaotic system

    Energy Technology Data Exchange (ETDEWEB)

    Muthukumar, P., E-mail: muthukumardgl@gmail.com; Balasubramaniam, P., E-mail: balugru@gmail.com [Department of Mathematics, Gandhigram Rural Institute‐Deemed University, Gandhigram 624 302, Tamilnadu (India); Ratnavelu, K., E-mail: kuru052001@gmail.com [Faculty of Science, Institute of Mathematical Sciences, University of Malaya, 50603 Kuala Lumpur (Malaysia)

    2014-09-01

    In this paper, we design a new three dimensional King Cobra face shaped fractional order chaotic system. The multi-scale synchronization scheme of two fractional order chaotic systems is described. The necessary conditions for the multi-scale synchronization of two identical fractional order King Cobra chaotic systems are derived through feedback control. A new cryptosystem is proposed for an image encryption and decryption by using synchronized fractional order King Cobra chaotic systems with the supports of multiple cryptographic assumptions. The security of the proposed cryptosystem is analyzed by the well known algebraic attacks. Numerical simulations are given to show the effectiveness of the proposed theoretical results.

  15. JEWISH IDEA: FROM KING TEMPLE TO KING STATE YAHUDİ İDEASI: KRAL MABEDİNDEN KRAL DEVLETE

    Directory of Open Access Journals (Sweden)

    Mustafa YİĞİTOĞLU

    2012-06-01

    Full Text Available The study focuses on a process that has become the main problem of Judaism. As the subject, this article is reflectiton the world and the beyond world of the point of view of Judaism. This actually means that the analysis in general terms the history of Jewish thought. Although concentrated in the research issue is not exactly a history of thought. But this article examines the structure of Judaism directly. Firstly in this research discusses King Solomon’s temple which was built as an indicator of Judaism is institutionalized and the idea of Jewish towards to King State. Bu çalışma Yahudiliğin temel sorunu haline gelen bir süreci ele almaktadır. Konu itibari ile Yahudiliğin dünyaya ve dünya ötesine bakış açısını yansıtmaktadır. Bu, aslında Yahudi düşünce tarihinin genel anlamda analizi demektir. Gerçi araştırmanın yoğunlaştığı husus tam anlamıyla bir düşünce tarihi değildir. Ancak alan itibariyle Yahudiliğin doğrudan yapısını inceleyen bir duruma haizdir.Araştırmada ilk olarak Yahudiliğin kurumsallaştığının bir göstergesi olan Kral Süleyman’ın inşa ettirdiği mabed; önemi, konumu ve etkisi gibi hususiyetleriyle tarihsel bir çerçevede ele alınmış, nihayetinde Kral Devlete doğru giden bir Yahudi düşüncesine yer verilmiştir.

  16. 3 CFR 8340 - Proclamation 8340 of January 15, 2009. Martin Luther King, Jr., Federal Holiday, 2009

    Science.gov (United States)

    2010-01-01

    ..., we believe it is self-evident that all men are created equal and that freedom is not a grant of government but a gift from the Author of Life. Dr. King trusted in these beliefs articulated in our founding...

  17. Interim Evaluation Results from New Flyer/Allison Hybrid Buses at King County Metro: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eberts, E.; Eudy, L.

    2005-05-01

    This paper prepared for the 2005 American Public Transportation Association Bus & Paratransit Conference discusses NREL/DOE evaluation of hybrid electric articulated transit buses operated by King County Metro.

  18. AFSC/RACE/SAP/Cummiskey: Red king crab sonic tagging and dive database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is data from a long-term monitoring project which utilized sonic tags to follow aggregations of red king crab in Womens Bay near Kodiak Alaska. The database...

  19. AFSC/RACE/SAP/Swiney: Red king crab fecundity and embryo and larval quality

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Stock assessment of Alaskan red king crab, Paralithodes camtschaticus (Tilesius, 1815), can be improved by incorporating reproductive output, which requires an...

  20. Early life history studies of the king crab: A progress report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Describes a study where Alaska King Crabs were brought down from the Bering Sea and placed in outside rearing ponds at the State of Washington's Marine Research...

  1. 2010 King County (WA) Dept of Natural Resources and Parks Lidar: Cedar River

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Watershed Sciences, Inc. (WS) collected Light Detection and Ranging (LiDAR) data and true-color orthophotographs of King County, WA from March 18 to March 20, 2010....

  2. AFSC/RACE/GAP/Nichol: Archival tag depth and temperature data from red king crab

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In December of 2009, a total of 135 adult male red king crab (Paralithodes camtschaticus) were tagged with depth and temperature recording archival tags and released...

  3. 76 FR 23335 - Wilderness Stewardship Plan/Environmental Impact Statement, Sequoia and Kings Canyon National...

    Science.gov (United States)

    2011-04-26

    ... proper food storage; party size; camping and campsites; human waste management; stock use; meadow... National Park Service Wilderness Stewardship Plan/Environmental Impact Statement, Sequoia and Kings Canyon... Intent to Prepare Environmental Impact Statement for Wilderness Stewardship Plan, Sequoia and...

  4. Week-long celebration of Dr. Martin Luther King Jr. legacy continues

    OpenAIRE

    Owczarski, Mark

    2006-01-01

    A wide range of educational and cultural programs and community service events are underway as Virginia Tech celebrates Dr. Martin Luther King Jr. Week Jan. 15-20. All events are free (unless otherwise noted) and open to the public.

  5. ON THE CONVERGENCE OF KING-WERNER ITERATIONMETHOD IN BANACH SPACE

    Institute of Scientific and Technical Information of China (English)

    Zheng-da Huang

    2000-01-01

    In this paper , a Kantorovitch-Ostrowskitype convergence theorem and an error estimate ofusing the information of higher derivativesat the center between initial points for King-Werner iteration method in Banachspace are established.

  6. Spatial Vegetation Data for Sequoia and Kings Canyon National Parks Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — High resolution vegetation polygons mapped by the National Park Service. The Vegetation Map of Sequoia and Kings Canyon National Parks was produced over an eight...

  7. Maya Angelou to speak during Virginia Tech's third annual Martin Luther King Jr. celebration

    OpenAIRE

    Williams, Meghan

    2008-01-01

    A remarkable woman who is hailed as one of the greatest voices of contemporary literature, Maya Angelou, will be a guest speaker during the third annual Dr. Martin Luther King Jr. celebration at Virginia Tech.

  8. Maya Angelou to visit Virginia Tech during third annual Martin Luther King, Jr. celebration

    OpenAIRE

    Williams, Meghan

    2007-01-01

    A remarkable woman who is hailed as one of the greatest voices of contemporary literature, Maya Angelou, will be a guest speaker during the third annual Dr. Martin Luther King Jr. celebration at Virginia Tech.

  9. Radiological Risk Assessment for King County Wastewater Treatment Division

    Energy Technology Data Exchange (ETDEWEB)

    Strom, Daniel J.

    2005-08-05

    Staff of the King County Wastewater Treatment Division (WTD) have concern about the aftermath of a radiological dispersion event (RDE) leading to the introduction of significant quantities of radioactive material into the combined sanitary and storm sewer system in King County, Washington. Radioactive material could come from the use of a radiological dispersion device (RDD). RDDs include "dirty bombs" that are not nuclear detonations but are explosives designed to spread radioactive material (National Council on Radiation Protection and Measurements (NCRP) 2001). Radioactive material also could come from deliberate introduction or dispersion of radioactive material into the environment, including waterways and water supply systems. This document develops plausible and/or likely scenarios, including the identification of likely radioactive materials and quantities of those radioactive materials to be involved. These include 60Co, 90Sr, 137Cs, 192Ir, 226Ra, plutonium, and 241Am. Two broad categories of scenarios are considered. The first category includes events that may be suspected from the outset, such as an explosion of a "dirty bomb" in downtown Seattle. The explosion would most likely be heard, but the type of explosion (e.g., sewer methane gas or RDD) may not be immediately known. Emergency first responders must be able to quickly detect the radioisotopes previously listed, assess the situation, and deploy a response to contain and mitigate (if possible) detrimental effects resulting from the incident. In such scenarios, advance notice of about an hour or two might be available before any contaminated wastewater reaches a treatment plant. The second category includes events that could go initially undetected by emergency personnel. Examples of such a scenario would be the inadvertent or surreptitious introduction of radioactive material into the sewer system. Intact rogue radioactive sources from industrial radiography devices, well-logging apparatus, or

  10. Updated Fiscal Impact Analysis for the Naval Submarine Base, Kings Bay, Georgia. Technical Appendices

    Science.gov (United States)

    1986-12-01

    any person wishing to enter the labor force. Thus, the only existing labor supply is actually the inflow of spouses of inmigrants who wish to work...The existing labor supply for the Kings Bay expansion is calculated in the model by assuming that 60 percent of the spouses of inmigrants who wish to...work. The existing labor supply for the Kings Bay expansion is calculated in the model by assuming that 60 percent of the spouses of inmigrants from the

  11. Microhabitat selection, demography, and correlates of home range size for the King Rail (Rallus elegans)

    Science.gov (United States)

    Pickens, Bradley A.; King, Sammy L.

    2013-01-01

    Animal movements and habitat selection within the home range, or microhabitat selection, can provide insights into habitat requirements, such as foraging and area requirements. The King Rail (Rallus elegans) is a wetland bird of high conservation concern in the United States, but little is known about its movements, habitats, or demography. King Rails (n = 34) were captured during the 2010–2011 breeding seasons in the coastal marshes of southwest Louisiana and southeast Texas. Radio telemetry and direct habitat surveys of King Rail locations were conducted to estimate home ranges and microhabitat selection. Within home ranges, King Rails selected for greater plant species richness and comparatively greater coverage of Phragmites australis, Typha spp., and Schoenoplectus robustus. King Rails were found closer to open water compared to random locations placed 50 m from King Rail locations. Home ranges (n = 22) varied from 0.8–32.8 ha and differed greatly among sites. Home range size did not vary by year or sex; however, increased open water, with a maximum of 29% observed in the study, was correlated with smaller home ranges. Breeding season cumulative survivorship was 89% ± 22% in 2010 and 61% ± 43% in 2011, which coincided with a drought. With an equal search effort, King Rail chicks and juveniles observed in May-June decreased from 110 in 2010 to only 16 in the drier year of 2011. The findings show King Rail used marsh with ≤ 29% open water and had smaller home ranges when open water was more abundant.

  12. Community control of health services. Dr. Martin Luther King, Jr. Health Center's community management system.

    Science.gov (United States)

    Tichy, N M; Taylor, J I

    1976-01-01

    This article presents the case of Dr. Martin Luther King Jr. Health Center's unique community management system in which neighborhood workers have been developed to assume managerial responsibilities and are directing the Center. The Martin Luther King Center experience is instructive because the Center was able to achieve significant community control by focusing primarily on the internal dimension of control, namely, management, without experiencing destructive conflicts and the deterioration of health services.

  13. Prevalence of Glomerular Diseases: King Khalid University Hospital, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Mitwalli A

    2000-01-01

    Full Text Available To obtain a more recent and comprehensive insight into the prevalence of glomerular diseases in our patient population, medical records of 200 patients with biopsy proven glomerulonephritis (GN, between January 1994 and June 1999, at the King Khalid University Hospital, Riyadh, Saudi Arabia were analyzed. Primary glomerular disease was found to be the most prevalent, accounting for 63.5% of all glomerular diseases. Among primary glomerular diseases, focal and segmental glomerulosclerosis (FSGS was the most common histological lesion (34.6% and was associated with a high prevalence of hypertension (86.4%, nephrotic syndrome (68.18%, hematuria (63.6% and renal functional impairment (27.3%. Mesangioproliferative GN was the second most common lesion (25.1% followed by mesangiocapillary GN (15.7%, IgA nephropathy (10.2%, and minimal change disease (8.5%. Amongst secondary glomerular diseases, lupus nephritis was the most prevalent (24.5%. In conclusion, primary glomerular diseases constituted the commonest group encountered and the prevalence of FSGS was quite high with male sex and young adults predominating. FSGS was also associated with a high prevalence of end-stage renal disease. Further collaborative studies are necessary to explore the predisposing factors and associations of glomerular disease, especially FSGS.

  14. Maternal telomere length inheritance in the king penguin.

    Science.gov (United States)

    Reichert, S; Rojas, E R; Zahn, S; Robin, J-P; Criscuolo, F; Massemin, S

    2015-01-01

    Telomeres are emerging as a biomarker for ageing and survival, and are likely important in shaping life-history trade-offs. In particular, telomere length with which one starts in life has been linked to lifelong survival, suggesting that early telomere dynamics are somehow related to life-history trajectories. This result highlights the importance of determining the extent to which telomere length is inherited, as a crucial factor determining early life telomere length. Given the scarcity of species for which telomere length inheritance has been studied, it is pressing to assess the generality of telomere length inheritance patterns. Further, information on how this pattern changes over the course of growth in individuals living under natural conditions should provide some insight on the extent to which environmental constraints also shape telomere dynamics. To fill this gap partly, we followed telomere inheritance in a population of king penguins (Aptenodytes patagonicus). We tested for paternal and maternal influence on chick initial telomere length (10 days old after hatching), and how these relationships changed with chick age (at 70, 200 and 300 days old). Based on a correlative approach, offspring telomere length was positively associated with maternal telomere length early in life (at 10 days old). However, this relationship was not significant at older ages. These data suggest that telomere length in birds is maternally inherited. Nonetheless, the influence of environmental conditions during growth remained an important factor shaping telomere length, as the maternal link disappeared with chicks' age.

  15. On Cas A, Cassini, Comets and King Charles

    CERN Document Server

    Soria, Roberto; Ohtsuka, Yasuyo

    2013-01-01

    We re-examine the long-standing problem of the date of the Cassiopeia A supernova (SN), in view of recent claims that it might be the 1630 "noon-star" seen at the birth of King Charles II. We do not support this identification, based on the expected brightness of a Type-IIb SN (too faint to be seen in daylight), the extrapolated motion of the ejecta (inconsistent with a date earlier than 1650), the lack of any scientific follow-up observations, the lack of any mention of it in Asian archives. The origin of the 1630 noon-star event (if real) remains a mystery; there was a bright comet in 1630 June but no evidence to determine whether or not it was visible in daylight. Instead, we present French reports about a 4th-magnitude star discovered by Cassini in Cassiopeia in or shortly before 1671, which was not seen before or since. The brightness is consistent with what we expect for the Cas A SN; the date is consistent with the extrapolated motion of the ejecta. We argue that this source could be the long-sought SN...

  16. Color ornaments and territory position in king penguins.

    Science.gov (United States)

    Keddar, Ismaël; Jouventin, Pierre; Dobson, F Stephen

    2015-10-01

    King penguins exhibit mutual color ornamentation of feathers and beak color. They breed in dense colonies and produce a single chick every 2 years. Thus, males and females must choose partners carefully to be reproductively successful, and auricular patches of males and UV coloration of beak spots have been shown to influence mate choice. Position in the breeding colony is also important to reproductive success, with pairs on the edge of the colony less successful than those in the center. We studied the mutual ornaments, individual condition, and position of pairs in their breeding colony. Males were significantly larger than females in size, body mass, and auricular patch size. Within pairs, auricular patch size of males and females were significantly correlated, and male auricular patch size and body mass were significantly associated, suggesting a link between this ornament and male body condition. Moving from the edge to the center of the colony, pairs had larger yellow-orange auricular patches, indicating a link between this ornament and settlement in higher quality territories in the center of the colony. Pairs were also less brightly brown colored on the breast and less saturated in UV color of the beak spot. Since we observed pairs that were settling for egg laying, location in the colony may have reflected aspects of pair condition, rather than later jockeying for positioning using ornaments as signals of behavioral dominance.

  17. Phytochemical Studies and Antioxidant Activities of Artocarpus scortechinii King

    Directory of Open Access Journals (Sweden)

    Norzafneza Mohd Arriffin

    2017-05-01

    Full Text Available Six known compounds identified as 4',5-dihydroxy-6,7-(2,2-dimethylpyrano-2'-methoxy-8-γ,γ-dimethylallyflavone (1, cudraflavone A (2, artocarpin(3, cycloartobiloxanthone (4, artonin E (5 and oxyresveratrol (6 were isolated from the stem barks of Artocapus scortechinii King. Another four compounds namely macakurzin C (7, flemichapparin A (8, luteolin (9 and apigenin (10 were isolated from the leaves. Structures of all pure compounds were elucidated spectroscopically using 1D NMR ( 1H, 13C, DEPT, 2D NMR (COSY, HMQC, HMBC, MS and FTIR, as well as by comparison with literature data. All isolated compounds were evaluated for their antioxidant capacities using 2,2-diphenyl-1-picrylhydrazyl (DPPH, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS and ferric reducing antioxidant potential (FRAP assays. Luteolin (9 showed the best ability to act as DPPH free radical scavenger with IC 50 value of 9.51 µM. Luteolin (9 also exhibited the strongest scavenger and potent ferric ion reducer compared to other isolated compounds in the ABTS and FRAP assays with IC 50 value of 124.4µM and 4.07 ± 0.180 mM FRAP equivalent respectively.

  18. Lee de Forest King of Radio, Television, and Film

    CERN Document Server

    Adams, Mike

    2012-01-01

    Lee de Forest, Yale doctorate and Oscar winner, gave voice to the radio and the motion picture. Yet by the 1930s, after the radio and the Talkies were regular features of American life, Lee de Forest had seemingly lost everything. Why? Why didn’t he receive the recognition and acclaim he sought his entire life until years later in 1959, when he was awarded an Oscar? A lifelong innovator, Lee de Forest invented the three-element vacuum tube which he developed between 1906 and 1916 as a detector, amplifier, and oscillator of radio waves. As early as 1907, he was broadcasting music programming. In 1918, he began to develop a system for recording and playing back sound by using light patterns on motion picture film. In order to promote and demonstrate his process he made hundreds of short sound films, found theatres for their showing, and issued publicity to gain audiences for his invention. While he received many patents for this technology, he was ignored by the film industry. Lee de Forest, King of Radio, Te...

  19. On Cas A, Cassini, Comets, and King Charles

    Science.gov (United States)

    Soria, Roberto; Balestrieri, Riccardo; Ohtsuka, Yasuyo

    2013-03-01

    We re-examine the long-standing problem of the date of the Cassiopeia A supernova (SN), in view of recent claims that it might be the 1630 'noon-star' seen at the birth of King Charles II. We do not support this identification, based on the expected brightness of a Type-IIb SN (too faint to be seen in daylight), the extrapolated motion of the ejecta (inconsistent with a date earlier than 1650), the lack of any scientific follow-up observations, the lack of any mention of it in Asian archives. The origin of the 1630 noon-star event (if real) remains a mystery; there was a bright comet in 1630 June but no evidence to determine whether or not it was visible in daylight. Instead, we present French reports about a fourth-magnitude star discovered by Cassini in Cassiopeia in or shortly before 1671, which was not seen before or since. The brightness is consistent with what we expect for the Cas A SN; the date is consistent with the extrapolated motion of the ejecta. We argue that this source could be the long-sought SN.

  20. Did King Herod suffer from a rheumatic disease?

    Science.gov (United States)

    Leatherwood, Cianna; Panush, Richard S

    2017-04-01

    Herod the Great was appointed "king of Jews," to govern Judea, by the Roman Emperor and Senate. He lived from 73/74 BCE to 4 CE. He died with an illness and symptoms that have been the source of considerable speculation. Richard Strauss depicted Herod in his classic opera, "Salome." That opera was derived from a play of the same name by Oscar Wilde, which was based on an 1876 painting, "Salome Dancing Before Herod," by Gustave Moreau. The operatic Herod was afflicted with an illness characterized by dementia, hallucinations, paranoia, alcoholism (from drinking the Emperor's wine), violence, twitches, and sterility; different interpretations showed him also with falls, chills, shaking, thirst, forgetfulness, and sleepiness, for which we suggest the novel diagnosis of chronic lead intoxication (which can manifest to rheumatologists as saturnine gout). He had compatible symptoms (encephalopathy and neuromuscular abnormalities) and consumed excessive quantities of imperial wine, known to be highly contaminated with lead and likely associated with similar symptoms among Roman aristocracy. Herod's demented cruelties-an oppressive reign which including the beheading of John the Baptist-exacerbated the political climate and may have contributed to the subsequent violent 7-year revolt culminating in the destruction of the second temple. How different might history have been if Herod the Great had been abstemious?

  1. Magnetometry at Uruk (Iraq): The city of King Gilgamesh

    Science.gov (United States)

    Fassbinder, J.; Becker, H.; van Ess, M.

    2003-04-01

    Uruk (Tell Warka) is one of the most famous sites for the early cultural development at Mesopotamia. The Sumerian city state was also important for the origin of writing and Uruk was the scene of action of mans oldest epic, the famous Epic of Gilgamesh (2600 B.C). During the time of the Sassanides, 400 A.D. the city was given up completely. Today the ruin is dominated by shallow hills and wadis, covered by pottery, mudbricks and slags. The area is totally free of modern buildings and far away from the modern village of Warka. Therefore it is an ideal place for uncompensated cesium magnetometry. The most sensational find was the discovery of a canal system inside the city. Furthermore the magnetogram shows the remains of buildings of the Babylonian type as well as garden structures, a middle Babylonian graveyard and the so called "New Years Temple" of the God Anu or Godess Ischtar. The city wall, which we prospected in a length of more than one kilometer, includes a water gate and is nearly 40 meters broad. From magnetometry it is evident that it was build by burned mudbricks as it was described by the Epic. In the west of the "New Years Temple" in the middle of the former Euphrates river we detected the remains of a building which may be interpreted as a burial. But if this building is the grave of the famous King Gilgamesh as it was described by the Epic of Gilgamesh it must remain speculative.

  2. Detection of integron integrase genes on King George Island, Antarctica

    Institute of Scientific and Technical Information of China (English)

    Vernica Antelo; Hctor Romero; Silvia Batista

    2015-01-01

    The presence and diversity of class 1 integrase gene (intI) sequences were evaluated by PCR using previously designed primers. Two clone libraries were constructed from DNA in sediment and microbial mat samples collected on Fildes Peninsula, King George Island, Antarctica.The libraries constructed from samples collected at Halfthree Point (HP) and Norma Cove (NC) contained 62 and 36 partial intI sequences, respectively. These sequences clustered into 10 different groups with <95% amino acid identity. Alignment of the deduced amino acid sequences with those from recognized integron-encoded integrases demonstrated the presence of highly conserved motifs characteristic of intI integrases. The HP library contained 42 nucleotide sequences identical to the class 1 intI gene found in a collection of trimethoprim-resistant (Tmpr) Antarctic Enterobacter sp. isolates, previously collected in the same area. These integrons, located on plasmids, had a genetic organization similar to that of pKOX105 from Klebsiella oxytoca. The 20 remaining HP and NC library sequences were similar to integrase sequences previously determined in a metagenomic analysis of environmental samples. We have demonstrated the presence of integron integrase genes in Antarctic sediment samples. About half these genes were very similar to the class 1 integrons found in human-associated microbiota, suggesting that they originated from human-dominated ecosystems. The remaining integrase genes were probably associated with endemic bacteria.

  3. Truncated ambition: Thomas King Chambers, MD (1817-1889).

    Science.gov (United States)

    Drain, Susan

    2016-05-01

    Thomas King Chambers clearly intended to be a physician of note and at times indeed he was mentioned in the same breath as Sir James Paget (1814-1899), Sir Henry Acland (1815-1900) and Francis Anstie (1833-1874). At the time of his death his career was pronounced 'less than brilliant though far from inglorious'. He had made all the right political moves-networking through the medical societies, marrying well and even accompanying the Prince of Wales on his first foreign tour. He wanted to be more than a society doctor, however: he published his clinical lectures and original research, proposed a new paradigm for medicine that he dubbed 'the renewal of life' and found his ideas taken up enthusiastically in the United States. Alas, his career foundered when he suffered an aneurysm and underwent amputation through the thigh. Nevertheless, he made significant contributions to the profession through his service on the General Medical Council and to medical education, in particular to medical education for women, through his strong support of the London School of Medicine for Women. To examine his life is to revisit what makes a life meaningful and worthwhile, for Chambers' life, unlike his body, is remarkably whole.

  4. Speciation, range contraction and extinction in the endemic New Zealand King Shag complex.

    Science.gov (United States)

    Rawlence, Nicolas J; Till, Charlotte E; Easton, Luke J; Spencer, Hamish G; Schuckard, Rob; Melville, David S; Scofield, R Paul; Tennyson, Alan J D; Rayner, Matt J; Waters, Jonathan M; Kennedy, Martyn

    2017-10-01

    New Zealand's endemic King Shag (Leucocarbo carunculatus) has occupied only a narrow portion of the northeastern South Island for at least the past 240years. However, pre-human Holocene fossil and archaeological remains have suggested a far more widespread distribution of the three Leucocarbo species (King, Otago, Foveaux) on mainland New Zealand at the time of Polynesian settlement in the late 13th Century CE. We use modern and ancient DNA, and morphometric and osteological analyses, of modern King Shags and Holocene fossil Leucocarbo remains to assess the pre-human distribution and taxonomic status of the King Shag on mainland New Zealand, and the resultant conservation implications. Our analyses show that the King Shag was formerly widespread around southern coasts of the North Island and the northern parts of the South Island but experienced population and lineage extinctions, and range contraction, probably after Polynesian arrival. This history parallels range contractions of other New Zealand seabirds. Conservation management of the King Shag should take into account this species narrow distribution and probable reduced genetic diversity. Moreover, combined genetic, morphometric and osteological analyses of prehistoric material from mainland New Zealand suggest that the now extinct northern New Zealand Leucocarbo populations comprised a unique lineage. Although these distinctive populations were previously assigned to the King Shag (based on morphological similarities and geographic proximity to modern Leucocarbo populations), we herein describe them as a new species, the Kohatu Shag (Leucocarbo septentrionalis). The extinction of this species further highlights the dramatic impacts Polynesians and introduced predators had on New Zealand's coastal and marine biodiversity. The prehistoric presence of at least four species of Leucocarbo shag on mainland NZ further highlights its status as a biodiversity hotspot for Phalacrocoracidae. Copyright © 2017 Elsevier

  5. Overvåking av norsk kosthold - metoder og resultater

    Directory of Open Access Journals (Sweden)

    Lars Johansson

    2009-11-01

    Full Text Available  SAMMENDRAGKunnskap om endringer i matvarenes sammensetning og befolkningens kosthold er grunnleggende for utformingog oppfølging av en helsefremmende mat- og ernæringspolitikk. Dagens system for overvåking avkostholdet bygger først og fremst på en matvaredatabase og opplysninger om forbruket av matvarer fra tretyper datasett; matforsyningsstatistikk, forbruksundersøkelser og kostholdsundersøkelser. Det avgis årlig envurdering av utviklingen i norsk kosthold i forhold til mat- og ernæringspolitiske målsettinger. Det norskesystemet for overvåking av kostholdet er blitt betydelig styrket i løpet av 1990-årene ved innføringen avregelmessige kostholdsundersøkelser blant landsrepresentative utvalg av befolkningen i ulike aldersgrupperog økte ressurser til analyse av næringsinnholdet i matvarer. Det er imidlertid beskjedent sammenlignet meddatainnsamlingen i land som USA og Storbritannia. Det norske overvåkingssystemet er forsatt i enutviklingsfase, og det må justeres og kompletteres etter hvert. Dessuten vil det arbeides med å kvalitetssikredatainnsamlingen.Johansson L. Surveillance of the diet in Norway – methods and results.Nor J Epidemiol ENGLISH SUMMARYKnowledge about changes in composition and intake of foods, as well as changes in the prevalence of dietrelatedhealth problems is fundamental for an effective food and nutrition policy. The National Council onNutrition and Physical Activity is responsible for evaluating changes in the diet. Annually the Council publishesreports about trends in the Norwegian diet, and suggests measures to improve the diet. The Council, incooperation with the National Food Authority and the Institute for Nutrition Research, University of Oslo,has established a national food and dietary surveillance system. This system is mainly based on a fooddatabase and food consumption data. The food consumption data include three principally different datasets: food supplies, household consumption surveys

  6. The Russian secret service and King Alexander Obrenović of Serbia (1900-1903

    Directory of Open Access Journals (Sweden)

    Rajić Suzana

    2012-01-01

    Full Text Available The period of 1900-1903 saw three phases of cooperation between the Rus­sian Secret Service (Okhrana and King Alexander Obrenović of Serbia. It is safe to say that the Secret Service operated in Serbia as an extended arm of the Russian Ministry of Foreign Affairs, i.e. of its diplomatic mission in Belgrade. Its goal was to fortify the position of Russia in Serbia after King Alexander’s wedding and the departure of his father, ex-King Milan (who abdicated in 1889 in favour of his minor son, from the country. The Serbian King, however, benefited little from the cooperation, because he did not receive assistance from the Secret Service when he needed it most. Thus, the issue of conspiracy against his life was lightly treated throughout 1902 until his assassination in 1903. In the third and last period of cooperation, from the beginning of 1902 until the King’s assassination on 11 June 1903,1 the Russian ministries of Internal and Foreign Affairs forbade the agents to receive money from the Serbian King and relieved them of any duty regarding the protection of his life. [Projekat Ministarstva nauke Republike Srbije, br. 177014: Serbian nation: Integrating and disintegrating processes

  7. International importance of the eastern Chukchi Sea as a staging area for migrating king eiders

    Science.gov (United States)

    Oppel, S.; Dickson, D.L.; Powell, A.N.

    2009-01-01

    The evaluation of habitats used by arctic birds on migration is crucial for their conservation. We explored the importance of the eastern Chukchi Sea (ECS) as a staging area for king eiders (Somateria spectabilis) migrating between breeding areas in Siberia and western North America and wintering areas in the Bering Sea. We tracked 190 king eiders with satellite transmitters between 1997 and 2007. In late summer, 74% of satellite-tracked king eiders migrating south staged in the ECS for 13 ?? 13 (SD) days between late June and early November. During spring migration, king eiders staged in the ECS between mid-April and early June for 21 ?? 10 days. All instrumented birds migrating to breeding grounds in western North America (n = 62), and 6 of 11 males migrating to breeding grounds in Siberia, used this area for at least 1 week during spring migration. The importance of this staging area renders it possible that industrial development could adversely affect king eider populations in both Siberia and North America. ?? 2009 US Government.

  8. Tissue Doppler imaging for detection of radial and longitudinal myocardial dysfunction in a family of cats affected by dystrophin-deficient hypertrophic muscular dystrophy.

    Science.gov (United States)

    Chetboul, Valérie; Blot, Stephane; Sampedrano, Carolina Carlos; Thibaud, Jean-Laurent; Granger, Nicolas; Tissier, Renaud; Bruneval, Patrick; Gaschen, Frederic; Gouni, Vassiliki; Nicolle, Audrey P; Pouchelon, Jean-Louis

    2006-01-01

    Diagnosis of feline hypertrophic cardiomyopathy currently is based on the presence of myocardial hypertrophy detected using conventional echocardiography. The accuracy of tissue Doppler imaging (TDI) for earlier detection of the disease has never been described. The objective of this sudy was to quantify left ventricular free wall (LVFW) velocities in cats with hypertrophic muscular dystrophy (HFMD) during preclinical cardiomyopathy using TDI. The study animals included 22 healthy controls and 7 cats belonging to a family of cats with HFMD (2 affected adult males, 2 heterozygous adult females, one 2.5-month-old affected male kitten, and 2 phenotypically normal female kittens from the same litter). All cats were examined via conventional echocardiography and 2-dimensional color TDI. No LVFW hypertrophy was detected in the 2 carriers or in the affected kitten when using conventional echocardiography and histologic examination, respectively. The LVFW also was normal for 1 affected male and at the upper limit of normal for the 2nd male. Conversely, LVFW dysfunction was detected in all affected and carrier cats with HFMD when using TDI. TDI consistently detects LVFW dysfunction in cats with HFMD despite the absence of myocardial hypertrophy. Therefore, TDI appears more sensitive than conventional echocardiography in detecting regional myocardial abnormalities.

  9. A new technique for the quantitative assessment of 8-oxoguanine in nuclear DNA as a marker of oxidative stress. Application to dystrophin-deficient DMD skeletal muscles.

    Science.gov (United States)

    Nakae, Yoshiko; Stoward, Peter J; Bespalov, Ivan A; Melamede, Robert J; Wallace, Susan S

    2005-09-01

    This is the first report on the development of an immunohistochemical technique, combined with quantitative image analysis, for the assessment of oxidative stress quantitatively in nuclear DNA in situ, and its application to measure DNA damage in Duchenne muscular dystrophic (DMD) muscles. Three sequential staining procedures for cell nuclei, a cell marker, and a product of oxidative DNA damage, 8-oxoguanine (8-oxoG), were performed. First, the nuclei in muscle sections were stained with Neutral Red followed by the capture of their images with an image analysis system used for absorbance measurements. Second, the same sections were then immunostained for laminin in basement membranes as the cell marker. Next, the sections were treated with 2 N HCl to remove the bound Neutral Red and to denature tissue DNA. Third, the sections were immunostained for 8-oxoG in DNA, using diaminobenzidine (DAB) to reveal the antibody complex. This was followed by capture of the images of the immunostained sections as previously. The absorbances at 451.2 nm of bound Neutral Red and DAB polymer oxides, the final product of 8-oxoG immunostaining, were measured in the same myonuclei in the sections. Analysis of these absorbances permitted indices of the 8-oxoG content, independent of the nuclear densities, to be determined in nuclear DNA in single myofibres and myosatellite cells surrounded by basement membranes. We found that the mean index for the myonuclei in biceps brachii muscles of 2- to 7-year-old patients was 14% higher than that in age-matched normal controls. This finding of the increased oxidative stress in the myonuclei in young DMD muscles agrees with the previous reports of increased oxidative stress in the cytoplasm in the DMD myofibres and myosatellite cells. The present technique for the quantitative assessment of oxidative stress in nuclear DNA in situ is applicable not only in biomedical research but also in the development of effective drugs for degenerative diseases related to oxidative stress.

  10. Influence of Botulinumtoxin A on the Expression of Adult MyHC Isoforms in the Masticatory Muscles in Dystrophin-Deficient Mice (Mdx-Mice

    Directory of Open Access Journals (Sweden)

    Ute Ulrike Botzenhart

    2016-01-01

    Full Text Available The most widespread animal model to investigate Duchenne muscular dystrophy is the mdx-mouse. In contrast to humans, phases of muscle degeneration are replaced by regeneration processes; hence there is only a restricted time slot for research. The aim of the study was to investigate if an intramuscular injection of BTX-A is able to break down muscle regeneration and has direct implications on the gene expression of myosin heavy chains in the corresponding treated and untreated muscles. Therefore, paralysis of the right masseter muscle was induced in adult healthy and dystrophic mice by a specific intramuscular injection of BTX-A. After 21 days the mRNA expression and protein content of MyHC isoforms of the right and left masseter, temporal, and the tongue muscle were determined using quantitative RT-PCR and Western blot technique. MyHC-IIa and MyHC-I-mRNA expression significantly increased in the paralyzed masseter muscle of control-mice, whereas MyHC-IIb and MyHC-IIx/d-mRNA were decreased. In dystrophic muscles no effect of BTX-A could be detected at the level of MyHC. This study suggests that BTX-A injection is a suitable method to simulate DMD-pathogenesis in healthy mice but further investigations are necessary to fully analyse the BTX-A effect and to generate sustained muscular atrophy in mdx-mice.

  11. Influence of Botulinumtoxin A on the Expression of Adult MyHC Isoforms in the Masticatory Muscles in Dystrophin-Deficient Mice (Mdx-Mice)

    Science.gov (United States)

    Todorov, Teodor

    2016-01-01

    The most widespread animal model to investigate Duchenne muscular dystrophy is the mdx-mouse. In contrast to humans, phases of muscle degeneration are replaced by regeneration processes; hence there is only a restricted time slot for research. The aim of the study was to investigate if an intramuscular injection of BTX-A is able to break down muscle regeneration and has direct implications on the gene expression of myosin heavy chains in the corresponding treated and untreated muscles. Therefore, paralysis of the right masseter muscle was induced in adult healthy and dystrophic mice by a specific intramuscular injection of BTX-A. After 21 days the mRNA expression and protein content of MyHC isoforms of the right and left masseter, temporal, and the tongue muscle were determined using quantitative RT-PCR and Western blot technique. MyHC-IIa and MyHC-I-mRNA expression significantly increased in the paralyzed masseter muscle of control-mice, whereas MyHC-IIb and MyHC-IIx/d-mRNA were decreased. In dystrophic muscles no effect of BTX-A could be detected at the level of MyHC. This study suggests that BTX-A injection is a suitable method to simulate DMD-pathogenesis in healthy mice but further investigations are necessary to fully analyse the BTX-A effect and to generate sustained muscular atrophy in mdx-mice. PMID:27689088

  12. Modern sedimentation patterns in Potter Cove, King George Island, Antarctica

    Science.gov (United States)

    Hass, H. Christian; Kuhn, Gerhard; Wölfl, Anne-Cathrin; Wittenberg, Nina; Betzler, Christian

    2013-04-01

    IMCOAST among a number of other initiatives investigates the modern and the late Holocene environmental development of south King George Island with a strong emphasis on Maxwell Bay and its tributary fjord Potter Cove (maximum water depth: about 200 m). In this part of the project we aim at reconstructing the modern sediment distribution in the inner part of Potter Cove using an acoustic ground discrimination system (RoxAnn) and more than136 ground-truth samples. Over the past 20 years the air temperatures in the immediate working area increased by more than 0.6 K (Schloss et al. 2012) which is less than in other parts of the West Antarctic Peninsula (WAP) but it is still in the range of the recovery of temperatures from the Little Ice Age maximum to the beginning of the 20th century. Potter Cove is a small fjord characterized by a series of moraine ridges produced by a tidewater glacier (Fourcade Glacier). Presumably, the farthest moraine is not much older than about 500 years (LIA maximum), hence the sediment cover is rather thin as evidenced by high resolution seismic data. Since a few years at least the better part of the tidewater glacier retreated onto the island's mainland. It is suggested that such a fundamental change in the fjord's physiography has also changed sedimentation patterns in the area. Potter Cove is characterized by silty-clayey sediments in the deeper inner parts of the cove. Sediments are coarser (fine to coarse sands and boulders) in the shallower areas; they also coarsen from the innermost basin to the mouth of the fjord. Textural structures follow the seabed morphology, i.e. small v-shaped passages through the moraine ridges. The glacier still produces large amounts of turbid melt waters that enter the cove at various places. We presume that very fine-grained sediments fall out from the meltwater plumes and are distributed by mid-depth or even bottom currents, thus suggesting an anti-estuarine circulation pattern. Older sediments that are

  13. Climate Controlled Sedimentation in Maxwell Bay, King George Island, Antarctica

    Science.gov (United States)

    Hass, H.; Kuhn, G.; Wittenberg, N.; Woelfl, A.; Betzler, C.

    2012-12-01

    Climatic change in Antarctica is strongest over the Antarctic Peninsula where in places the annual mean temperatures increased by 0.5 K per decade through the past 60 years. The impact of this warming trend is clearly visible in the form of retreating glaciers and melting ice sheets, loss of sea ice and strong meltwater discharge into the coastal zone. While it is generally accepted that the rapidity of the present climate change bears a significant anthropogenic aspect, it is not clear whether the effects caused by the warming trend are exceptional and unprecedented or whether the reaction of the environment is similar to that of earlier climate phases such as the Medieval Warm Period (MWP) about 1,000 years ago. One of the major goals of the joint international research project IMCOAST is to investigate the strength of the recent warming trend and its impact on the marine environment of the West Antarctic Peninsula (WAP). The study we present here reveals the Upper Holocene climatic history based on high-resolution sediment cores from Maxwell Bay (King George Island, WAP) and information on the actual processes triggered or altered by the recent warming trend based on sedimentologic and hydroacoustic investigations in Potter Cove, a tributary fjord to Maxwell Bay. Long sediment cores from Maxwell Bay reveal grain-size changes that can be linked to cold and warm phases such as the Little Ice Age (LIA) and the MWP. Generally, warm phases are finer grained than cold phases as a result of longer and stronger melting processes during the warm phases. It is suggested that meltwater plumes carry fine-grained sediment out of the surrounding fjords into Maxwell Bay where it settles in suitable areas to produce sediments that have a modal value around 16 μm. This mode is largely absent in sediments deposited during e.g. the LIA. However, post LIA sediments are depleted in the 16 μm-mode sediment suggesting slightly different conditions during the last century. One reason

  14. Perimortem trauma in King Richard III: a skeletal analysis.

    Science.gov (United States)

    Appleby, Jo; Rutty, Guy N; Hainsworth, Sarah V; Woosnam-Savage, Robert C; Morgan, Bruno; Brough, Alison; Earp, Richard W; Robinson, Claire; King, Turi E; Morris, Mathew; Buckley, Richard

    2015-01-17

    Richard III was the last king of England to die in battle, but how he died is unknown. On Sept 4, 2012, a skeleton was excavated in Leicester that was identified as Richard. We investigated the trauma to the skeleton with modern forensic techniques, such as conventional CT and micro-CT scanning, to characterise the injuries and establish the probable cause of death. We assessed age and sex through direct analysis of the skeleton and from CT images. All bones were examined under direct light and multi-spectral illumination. We then scanned the skeleton with whole-body post-mortem CT. We subsequently examined bones with identified injuries with micro-CT. We deemed that trauma was perimortem when we recorded no evidence of healing and when breakage characteristics were typical of fresh bone. We used previous data to identify the weapons responsible for the recorded injuries. The skeleton was that of an adult man with a gracile build and severe scoliosis of the thoracic spine. Standard anthropological age estimation techniques based on dry bone analysis gave an age range between 20s and 30s. Standard post-mortem CT methods were used to assess rib end morphology, auricular surfaces, pubic symphyseal face, and cranial sutures, to produce a multifactorial narrower age range estimation of 30-34 years. We identified nine perimortem injuries to the skull and two to the postcranial skeleton. We identified no healed injuries. The injuries were consistent with those created by weapons from the later medieval period. We could not identify the specific order of the injuries, because they were all distinct, with no overlapping wounds. Three of the injuries-two to the inferior cranium and one to the pelvis-could have been fatal. The wounds to the skull suggest that Richard was not wearing a helmet, although the absence of defensive wounds on his arms and hands suggests he was still otherwise armoured. Therefore, the potentially fatal pelvis injury was probably received post mortem

  15. Martin Luther King, 40 ans après sa disparition

    OpenAIRE

    Hélène Harter

    2009-01-01

    Le 4 avril 1968 Martin Luther King est assassiné à Memphis. Moins de cinq ans après la mort du président Kennedy, les Etats-Unis sont à nouveau touchés par la violence politique. Cet article retrace le parcours qui a conduit le révérend King jusqu’à Memphis en cette année politiquement et socialement agitée. Comment sa mort est-elle vécue aux États-Unis ? Quelle mémoire conserve-t-on de lui aujourd’hui ?On April 4, 1968 Martin Luther King was assassinated in Memphis. Less than five years afte...

  16. Fifth Annual Report: 2008 Pre-Construction Eelgrass Monitoring and Propagation for King County Outfall Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, Dana L.; Judd, Chaeli; Thom, Ronald M.; Sather, Nichole K.; Kaufmann, Ronald M.

    2010-01-01

    This is the fifth and final report in a series documenting progress of the pre-construction eelgrass restoration and mitigation activities for the proposed King County Brightwater marine outfall, discharging to Puget Sound near Point Wells, Washington. King County began implementing a multiyear eelgrass monitoring and restoration program in 2004, with the primary goal of returning intertidal and shallow subtidal habitat and eelgrass to pre-construction conditions, after construction of the outfall. Major eelgrass mitigation program elements include: a) pre-construction monitoring, i.e., documenting initial eelgrass conditions and degree of fluctuation over a 5 year period prior to construction, b) eelgrass transplanting, including harvesting, offsite propagation and stockpiling of local plants for post-construction planting, and c) post-construction planting and subsequent monitoring, occurring in 2009 and beyond. The overall program is detailed in the Eelgrass Restoration and Biological Resources Implementation Workplan (King County 2008).

  17. No barrier to emergence of bathyal king crabs on the Antarctic shelf

    DEFF Research Database (Denmark)

    Aronson, Richard B.; Smith, Kathryn E.; Vos, Stephanie C.

    2015-01-01

    Significance For tens of millions of years, cold conditions have excluded shell-crushing fish and crustaceans from the continental shelf surrounding Antarctica. Rapid warming is now allowing predatory crustaceans to return. Our study of the continental slope off the western Antarctic Peninsula sh...... at 400–550 m. A cold-water barrier above 200 m could be breached within the next few decades. Emergence of king crabs on the shelf could have catastrophic consequences for the unique seafloor communities of Antarctica....... showed that abundant, predatory king crabs comprise a reproductively viable population at 841- to 2,266-m depth. Depth profiles of temperature, salinity, habitat structure, food availability, and predators indicate that there are no barriers to prevent king crabs from moving upward onto the outer shelf...

  18. Viewpoint: use of King's conceptual system, nursing informatics, and nursing classification systems for global communication.

    Science.gov (United States)

    Killeen, Mary B; King, Imogene M

    2007-01-01

    To propose a common nursing language for communication among members of the nursing community worldwide. The Taxonomy of Nursing Practice, nursing informatics literature, King's Theory of Goal Attainment applied to the nursing process. Several milestones in nursing in the 20th century indicated the need for a universal language for nursing. The nursing process provides a method for synthesis of nursing data, information, and knowledge and is congruent with Imogene King's Theory of Goal Attainment. The authors advocate for a common nursing language (nursing classification and terminology systems) that would unify nurses worldwide. Supported by nursing theory and technology, global communication would be enhanced for nurses and the interdisciplinary teams of which they are a part. Use of Imogene King's Conceptual System and Theory of Goal Attainment and the nursing specialty of Nursing Informatics are examples of nursing theory and technology to frame global communication.

  19. Five analogies between a King's Speech treatment and contemporary play therapies.

    Science.gov (United States)

    Terr, Lenore C

    2012-01-01

    Psychiatric patients frequently respond positively to play therapy, which may rely on psychoanalytic, Jungian, cognitive-behavioral, familial, school-based, or other theories. I wished to determine if there were unifying principles that tie together these various types of play treatments. The fact-based film, The King's Speech, vividly illustrates play utilized by Lionel Logue in his speech treatment (1926-1939) of the future King of England. In the film I found five analogies to the play therapy I employ in office practice. The play scenes in The King's Speech point to five unifying principles among contemporary play therapies: (1) the crucial nature of the relationship, (2) the centrality of having fun, (3) the occasional reliance on others, (4) the interjection of pithy talk, and (5) the usefulness of a little drama. No matter what theory a play therapist ascribes to, these five unifying principles should be kept in mind during treatment.

  20. Statistical Outliers and Dragon-Kings as Bose-Condensed Droplets

    CERN Document Server

    Yukalov, V I

    2012-01-01

    A theory of exceptional extreme events, characterized by their abnormal sizes compared with the rest of the distribution, is presented. Such outliers, called "dragon-kings", have been reported in the distribution of financial drawdowns, city-size distributions (e.g., Paris in France and London in the UK), in material failure, epileptic seizure intensities, and other systems. Within our theory, the large outliers are interpreted as droplets of Bose-Einstein condensate: the appearance of outliers is a natural consequence of the occurrence of Bose-Einstein condensation controlled by the relative degree of attraction, or utility, of the largest entities. For large populations, Zipf's law is recovered (except for the dragon-king outliers). The theory thus provides a parsimonious description of the possible coexistence of a power law distribution of event sizes (Zipf's law) and dragon-king outliers.

  1. At-sea distribution and habitat use in king penguins at sub-Antarctic Marion Island.

    Science.gov (United States)

    Pistorius, Pierre; Hindell, Mark; Crawford, Robert; Makhado, Azwianewi; Dyer, Bruce; Reisinger, Ryan

    2017-06-01

    King penguins make up the bulk of avian biomass on a number of sub-Antarctic islands where they have a large functional effect on terrestrial and marine ecosystems. The same applies at Marion Island where a substantial proportion of the world population breeds. In spite of their obvious ecological importance, the at-sea distribution and behavior of this population has until recently remained entirely unknown. In addressing this information deficiency, we deployed satellite-linked tracking instruments on 15 adult king penguins over 2 years, April 2008 and 2013, to study their post-guard foraging distribution and habitat preferences. Uniquely among adult king penguins, individuals by and large headed out against the prevailing Antarctic Circumpolar Current, foraging to the west and southwest of the island. On average, individuals ventured a maximum distance of 1,600 km from the colony, with three individuals foraging close to, or beyond, 3,500 km west of the colony. Birds were mostly foraging south of the Antarctic Polar Front and north of the southern boundary of the Antarctic Circumpolar Current. Habitat preferences were assessed using boosted regression tree models which indicated sea surface temperate, depth, and chorophyll a concentration to be the most important predictors of habitat selection. Interestingly, king penguins rapidly transited the eddy-rich area to the west of Marion Island, associated with the Southwest Indian Ocean Ridge, which has been shown to be important for foraging in other marine top predators. In accordance with this, the king penguins generally avoided areas with high eddy kinetic energy. The results from this first study into the behavioral ecology and at-sea distribution of king penguins at Marion Island contribute to our broader understanding of this species.

  2. The influence of the king on medical practice in ancient Mesopotamia.

    Science.gov (United States)

    Adamson, P B

    1989-01-01

    Rulers in ancient Mesopotamia were interested in their own health and, by the second millenium B.C., medicine was extended to the population, but not to the conquered people. Physicians were very few and under patronage and control of the king; they were a cast lower than priests and considered as skilled technicians, with a great influence. Surgeons and veterinary surgeons were also encouraged, but kings promulgated laws to reward and penalise surgeons for damage or trauma or failure to effect a cure of the patients, heritage of the lex talionis.

  3. Purcell and Dryden’s King Arthur and the Myth of the Golden Age King Arthur et le mythe de l’Âge d’Or

    Directory of Open Access Journals (Sweden)

    Andrea Trocha Van Nort

    2009-08-01

    Full Text Available Le King Arthur de Purcell et de Dryden, un semi-opéra ou opéra dramatique selon les termes de Dryden, rompt avec le mode héroïque anglais et façonne le récit de la légende arthurienne selon les critères de la mythologie gréco-romaine. Qu’on le lise d’un point de vue poétique ou politique, King Arthur fait revivre à la scène les valeurs d’un d’âge d’or et de paix et témoigne à sa manière de l’esthétique du théâtre de la Restauration anglaise.

  4. The solving of non-linear equation by King-Werner Iterative method%用King-Werner选代法求解非线性方程

    Institute of Scientific and Technical Information of China (English)

    吕彬

    2002-01-01

    King-Werner迭代是效率较高的方法,它每步的计值量与Newton迭代格式相同,组合代价也只比Newton迭代高一倍,而且有收敛阶1+(√2).我们所做工作是把King-Werner迭代法应用于求解非线性方程,f(x)+g(x)=0,此类方程的适应范围较广,研究它的数值解意义很大,近年来此类方程的研究也引起了人们的关注.

  5. "A Creative Psalm of Brotherhood": The (De)Constructive Play in Martin Luther King's "Letter from Birmingham Jail"

    Science.gov (United States)

    Gaipa, Mark

    2007-01-01

    Scholars have celebrated the spoken word in King's "Letter from Birmingham Jail," but they have overlooked the significance of the Letter's writing. In this essay I closely read King's act of writing the Letter, along with the figures of speech he employs in it, and I show how both--by enacting the mass media's ability to cross contexts--are…

  6. 基于KingView的MPS组态监控系统设计%Design of MPS configuration monitoring system based on KingView

    Institute of Scientific and Technical Information of China (English)

    陈天炎

    2012-01-01

    Based on the modular production system of German company FESTO,this paper designs an online real-time monitoring system for automated production line by KingView soft.System uses Siemens S7-300 series PLC as the main control device,designs the automatic control system hardware and software,implements communication between the PLC and PC,completes the development of the monitoring program and the system real-time online monitoring based on industrial configuration software KingView.%以德国FESTO公司的MPS模块化生产加工系统为基础,设计了一种基于Kingview组态王的自动化生产线实时在线监控系统.系统采用西门子S7-300系列PLC作为主要控制设备,完成自动控制系统的硬件和软件设计,实现PLC与上位机之间的通信,并利用工业组态软件KingView完成监控程序的开发,实现对该系统的实时在线监控.

  7. Escaping from allegories:cat’s eye and King Lear Escaping from allegories:cat’s eye and King Lear

    Directory of Open Access Journals (Sweden)

    Caroline Cakebread

    2008-04-01

    Full Text Available In her 1972 study of Canadian literature, aptly titled Survival, Margaret Atwood uses the symbol of the mirror to describe the difficulty faced by Canadian writers and artists, struggling to assert their voices in a country trying to define itself against a colonial past.Here, she sees Canada as squeezed between the overwhelming, colonizing powers of Great Britain on one side, and The United States on the other. In her view, a piece of art becomes a mirror. As she writes: If a country or a culture lacks such mirrors it has no way of knowing what it looks like; it must travel blind. If, as has long been the case in [Canada], the viewer is given a mirror that reflects not him but someone else, and told at the same time that the reflection he sees is himself, he will get a very distorted idea of what he is really like. He will also get a distorted idea of what other people are like: it’s hard to find out who anyone else is until you have found out who you are. (15-16 With its roots in Lacanian psychoanalysis, the mirror Atwood describes provides an unreliable reflection for burgeoning artists inCanada: up against the powerful countries that surround them she sees a major identity crisis. Sixteen years later, her 1988 novel, Cat’s Eye, treads similar ground, tracking as it does the passage of its protagonist—painter, Elaine Risley—through childhood in mid-century Canada to her development as an established artist in the 1980s. It is into this narrative that Atwood places extensive references to Shakespeare’s tragedy, King Lear—a play that deals with the notion of identity. Here, Lear’s question, “Who is it that can tell me who I am?” becomes Elaine’s, as she ventures back to Toronto to attend a retrospective of her work at a women’s art gallery named “Sub-Versions.” In her 1972 study of Canadian literature, aptly titled Survival, Margaret Atwood uses the symbol of the mirror to describe the difficulty faced

  8. Two questions from the time of king Bodin's rule

    Directory of Open Access Journals (Sweden)

    Živković Tibor

    2005-01-01

    Full Text Available In this paper we try to give reliable answer upon two major questions: did Bodin, king of Dioclea, capture Dyrrachion in 1085, as it is related in the Chronicle of the Priest of Dioclea, and when did he try to capture Dubrovnik (Ragusa. The capture of Dyrrachion is not mentioned at Ane Comnene's Alexias. Byzantine princess wrote that citizens of Dyrrachion surrender the town to her father, the Emperor Alexios, after the death of the Norman ruler Robert Guiscard in 1085. On the other hand, the Priest of Dioclea says that Bodin, after the death of Robert Guiscard captured Dyrrachion which he gave back to the Byzantines after he signed the peace treaty with the Emperor. Both statements are not clear enough, but detailed analysis of both writings shows that Bodin took northern part of the theme of Dyrrachion and most probably tried to negotiate surrender of town itself, but he failed. Bodin's military activities against the Byzantine possessions in the theme of Dyrrachion could be placed between 1085 and 1090 when he was captured, being forced to sign peace treaty. The charter of antipope Clement III issued in 1089 to the archbishop of Antibaris, contain list of bishops which served in Dioclea, and only one of them - the bishop of Dulcigno (Ulcinj, had been earlier under the archbishop of Dyrrachion. In other words, Bodin took a very small part of the theme of Dyrrachion and southern borders of Dioclea were approximately the same as in the time of his father Michael. The description of the siege of Dubrovnik is well preserved in Chronicle of the Priest of Dioclea as well by several other authors from Dubrovnik. The authors from Dubrovnik, which composed their Chronicles much later (from XIV to XVII century, made mistake in the chronology, assuming that the siege took place in 1104. Having at their disposal an old note, that Bodin's tower, which stood on the shores just opposite the wooden bridge which lead from Dubrovnik to the land, was captured on

  9. Radiological Instrumentation Assessment for King County Wastewater Treatment Division

    Energy Technology Data Exchange (ETDEWEB)

    Strom, Daniel J.; McConn, Ronald J.; Brodzinski, Ronald L.

    2005-05-19

    The King County Wastewater Treatment Division (WTD) have concern about the aftermath of a radiological dispersion event (RDE) leading to the introduction of significant quantities of radioactive material into its combined sanitary and storm sewer system. Radioactive material could come from the use of a radiological dispersion device (RDD). RDDs include "dirty bombs" that are not nuclear detonations but are explosives designed to spread radioactive material. Radioactive material also could come from deliberate introduction or dispersion of radioactive material into the environment, including waterways and water supply systems. Volume 2 of PNNL-15163 assesses the radiological instrumentation needs for detection of radiological or nuclear terrorism, in support of decisions to treat contaminated wastewater or to bypass the West Point Treatment Plant (WPTP), and in support of radiation protection of the workforce, the public, and the infrastructure of the WPTP. Fixed radiation detection instrumentation should be deployed in a defense-in-depth system that provides 1) early warning of significant radioactive material on the way to the WPTP, including identification of the radionuclide(s) and estimates of the soluble concentrations, with a floating detector located in the wet well at the Interbay Pump Station and telemetered via the internet to all authorized locations; 2) monitoring at strategic locations within the plant, including 2a) the pipe beyond the hydraulic ram in the bar screen room; 2b) above the collection funnels in the fine grit facility; 2c) in the sampling tank in the raw sewage pump room; and 2d) downstream of the concentration facilities that produce 6% blended and concentrated biosolids. Engineering challenges exist for these applications. It is necessary to deploy both ultra-sensitive detectors to provide early warning and identification and detectors capable of functioning in high-dose rate environments that are likely under some scenarios, capable

  10. PEMERIKSAAN DAYA HAMBAT EKTRAK METANOL DAUN TRISTANIA SUBAURICULATA KING TERHADAP PERTUMBUHAN KUMAN PSEUDOMONAS AERUGINOSA DAN STAPHYLOCOCCUS AUREUS

    Directory of Open Access Journals (Sweden)

    Yustini Alioes

    2011-05-01

    Full Text Available AbstrakTristania subauriculata King dikenal oleh penduduk sekitar Kelok Sembilan, Payakumbuh sebagai obat untuk mengobati penyakit kulit. Diduga Tristania subauriculata King mengandung suatu senyawa bioaktif yang bersifat sebagai anti bakteri.Untuk melihat efektifitas ekstrak metanol daun Tristania subauriculata King dalam menghambat pertumbuhan kuman Pseudomonas aeruginosa dan Staphylococcus aureus, telah dilakukan penelitian secara invitro dengan menggunakan metode difusi agar, pengamatan dilakukan dengan mengukur diameter daerah hambat yang terbentuk pada agar.Dari penelitian didapatkan adanya daya hambat ekstrak metanol daun Tristania subauriculata King 15% b/v dalam menghambat pertumbuhan kuman Pseudomonas aeruginosa dan Staphylococcus aureus. Daya hambat ini meningkat pada konsentrasi 30% b/v, 45% b/v, dan daya hambat terbesar pada konsentrasi 60% b/v yang terlihat dengan semakin besarnya diameter daerah bebas kuman yang dihasilkan.Kata kunci : Ekstrak Metanol daun Tristania subauriculata King, Diameterhambat, Pseudomonas aeruginosa dan Staphylococcus aureusAbstractTristania subauriculata King has been known by the people of Kelok Sembilan, Payakumbuh as the medicine to cure dermatopathy. It is thought that Tristania subauriculata King contains a bioactive constituent which acts as anti bacteria.To figure the effects of methanol extract of Tristania subauriculata King in holding the growth of Pseudomonas aeruginosa and Staphylococcus aureus,an invitro observation has been done using difusion agar method. The observation was done by measuring the diameter of inhibition area that has been formed.From the observation, it is found that there is inhibition capacity of methanol extract of Tristania subauriculata King 15% b/v in holding the growth ofARTIKEL PENELITIAN38Pseudomonas aeruginosa and Staphylococcus aureus. This inhibition capacity increase on the concentration of 30% b/v, 45% b/v, and the biggest inhibition capacity is on the

  11. Comparison of the King's and MiToS staging systems for ALS.

    Science.gov (United States)

    Fang, Ton; Al Khleifat, Ahmad; Stahl, Daniel R; Lazo La Torre, Claudia; Murphy, Caroline; Young, Carolyn; Shaw, Pamela J; Leigh, P Nigel; Al-Chalabi, Ammar

    2017-05-01

    To investigate and compare two ALS staging systems, King's clinical staging and Milano-Torino (MiToS) functional staging, using data from the LiCALS phase III clinical trial (EudraCT 2008-006891-31). Disease stage was derived retrospectively for each system from the ALS Functional Rating Scale-Revised subscores using standard methods. The two staging methods were then compared for timing of stages using box plots, correspondence using chi-square tests, agreement using a linearly weighted kappa coefficient and concordance using Spearman's rank correlation. For both systems, progressively higher stages occurred at progressively later proportions of the disease course, but the distribution differed between the two methods. King's stage 3 corresponded to MiToS stage 1 most frequently, with earlier King's stages 1 and 2 largely corresponding to MiToS stage 0 or 1. The Spearman correlation was 0.54. There was fair agreement between the two systems with kappa coefficient of 0.21. The distribution of timings shows that the two systems are complementary, with King's staging showing greatest resolution in early to mid-disease corresponding to clinical or disease burden, and MiToS staging having higher resolution for late disease, corresponding to functional involvement. We therefore propose using both staging systems when describing ALS.

  12. Siim Nestor soovitab : Goldie. Kevin Saunderson. Nicole Willis. King Britt / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2005-01-01

    Popmuusikaüritustest: briti muusik Goldie esineb jungle-muusikaga Tallinnas 21. apr. klubis Privé, DJ Kevin Saunderson 22. apr. klubis Privé, laulja Nicole Willis 27. apr. BonBon Jazz Lounge'il klubis BonBon, Philadelphia muusik King Britt ja Eesti ansambel Broken Time Orchestra esitlevad oma heliplaate

  13. 36 CFR 7.8 - Sequoia and Kings Canyon National Parks.

    Science.gov (United States)

    2010-07-01

    ... National Parks. 7.8 Section 7.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.8 Sequoia and Kings Canyon National Parks. (a) Dogs and cats. Dogs and cats are prohibited on any park land or trail except within...

  14. AFSC/RACE/SAP/Long: Effects of ocean acidification on blue king crab

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is data from a laboratory experiment in which blue king crab juveniles were held at three different pHs (ambient, pH 7.8, and pH 7.5) for a year. Growth,...

  15. Multiple Intelligences Patterns of Students at King Saud University and Its Relationship with Mathematics' Achievement

    Science.gov (United States)

    Kandeel, Refat A. A.

    2016-01-01

    The purpose of this study was to determine the multiple intelligences patterns of students at King Saud University and its relationship with academic achievement for the courses of Mathematics. The study sample consisted of 917 students were selected a stratified random manner, the descriptive analysis method and Pearson correlation were used, the…

  16. The Rule of Law and Civil Disobedience: The Case behind King's Letter from a Birmingham Jail

    Science.gov (United States)

    Kaplan, Howard

    2013-01-01

    Fifty years ago, the Reverend Dr. Martin Luther King Jr. wrote his "Letter from a Birmingham Jail." In exploring the story of the events behind the essay, and the Supreme Court case that resulted, "Walker v. Birmingham", 399 U.S. 307 (1967), educators will find a pedagogically powerful lens through which to review the seminal…

  17. King Lear, de Jean-Luc Godard: uma tragédia?

    Directory of Open Access Journals (Sweden)

    Thais Flores Nogueira Diniz

    1995-10-01

    Full Text Available The article discusses Shakespeare's King Lear fIlmic translationladaptation by Jean-Luc Godard as a transformationlnegation of genre. It also shows that the tilmmaker's non-conventional treatment oftheme and forro changes the play into a "mock-fIlm".

  18. Willingness to Communicate in English: A Case Study of EFL Students at King Khalid University

    Science.gov (United States)

    Mahdi, Dawood Ahmed

    2014-01-01

    The main purpose of learning a foreign language is to use it for meaningful and effective communication both inside and outside the classroom. This paper is devoted to identifying the main communication difficulties faced by EFL students at King Khalid University (KKU) and exploring the reasons that lie behind these difficulties. The paper…

  19. Saudi Female Students' Perceptions of Their Democratic Empowerment in the Classroom at King Saud University

    Science.gov (United States)

    Alajlan, Sarah Mohammed

    2016-01-01

    The purpose of this quantitative study is to describe female graduate students' perceptions about their democratic empowerment in the classroom at King Saud University in Saudi Arabia. Their perceptions are compared based on female students' tracks. It also investigates the obstacles for democratic empowerment that female students face in the…

  20. Participant Perspectives of the School Readiness Planning Process. Larry King Center Evaluation

    Science.gov (United States)

    Gifford, Beth; Evans, Kelly; Babinski, Leslie; Foster, Audrey

    2011-01-01

    In September 2009 the Council for Children's Rights unveiled the Larry King Center for Building Children's Futures (LKC). The LKC serves as a resource to the community "maximizing the effectiveness and impact of work being done for children by providers, agencies and funders." The LKC has chosen three initial priorities to address in…

  1. "Free at Last": Kennedy, King, and the Meaning of Liberty in the Disability Rights Movement

    Science.gov (United States)

    Turnbull, H. Rutherford, III

    2012-01-01

    There is a direct link connecting President Kennedy and Martin Luther King, Jr., to the causes of liberty, consent, choice, the least restrictive environment, and genuine community presence for people with intellectual and related developmental disabilities. This article connects the meaning of liberty in those civil rights movements to the…

  2. "I Have a Dream, Too!": The American Dream in Coretta Scott King Award-Winning Books

    Science.gov (United States)

    Parsons, Linda T.; Castleman, Michele

    2011-01-01

    The Coretta Scott King (CSK) Award, instituted in 1969 and recognized as an official award by the American Library Association (ALA) in 1982, is conferred annually to an African American author and an illustrator for their outstanding contributions to literature about the Black experience for children and young adults. A partial impetus for the…

  3. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    Science.gov (United States)

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  4. Dr Malcolm King Honoured at University of Alberta Annual General Meeting

    Directory of Open Access Journals (Sweden)

    2004-01-01

    Full Text Available On September 25, 2003, Dr Malcolm King, former Canadian Thoracic Society (CTS President and member, was honoured by the University of Alberta (U of A with the University of Alberta Board of Governors Award of Distinction for 2003. The following are highlights of an article written by Ryan Smith for ExpressNews.

  5. A PRIMARY STUDY OF FOSSIL HILL FLORA FROM FILDES PENINSULA OF KING GEORGE ISLAND, ANTARCTICA

    Institute of Scientific and Technical Information of China (English)

    1990-01-01

    The fossil plants studied in this paper were collected by the Chinese Antarctic Expeditions (1986—1987 and 1987—1988) from the locality Fossil Hill on the Fildes Peninsula southwest of the King George Island of the South Shetland Islands.

  6. If Dr. King Were a Principal: Building the "Beloved Community" in Schools

    Science.gov (United States)

    Hillis, Michael; Woolworth, Stephen

    2008-01-01

    In this article, the authors offer a more humanistic vision of educational community, one that is substantive in content yet flexible in its application to the diverse contexts in which American schooling occurs. In doing so, the authors turn specifically to the nonviolent philosophy of Dr. Martin Luther King, Jr. and consider what a school…

  7. Martin Luther King's "I Have a Dream": The Speech Event as Metaphor.

    Science.gov (United States)

    Alvarez, Alexandra

    1988-01-01

    Martin Luther King's speech is examined as a sermon in the Black Baptist tradition. The speech, which is a dialog between speaker and audience, has, in addition to the "message" contained in the code, a broader ethnographic meaning. The speech event itself is metaphorical in nature, signaling political protest. (Author/BJV)

  8. King's "I Have a Dream" Speech: A Case Study of Incorporating Orality in Rhetorical Criticism.

    Science.gov (United States)

    Weitzel, Al

    1994-01-01

    Emphasizes the importance of orality, a dimension of textual authenticity, that can influence the content, the form of a speech transcript, and the act of criticism. Demonstrates, with Martin Luther King's "I Have A Dream" speech, that incorporation of orality does not necessarily provide answers to all of the critic's questions. (SR)

  9. A Pedagogical Treatment of King's "I Have a Dream" Speech: Toward Incorporating Orality in Rhetorical Criticism.

    Science.gov (United States)

    Weitzel, Al R.

    This paper first discusses the ways in which Martin Luther King's "I Have a Dream" speech demonstrates some of the fundamental principles that should be used to teach rhetorical criticism, and then offers a microscopic, intrinsic criticism of the speech. The paper's four sections (1) review the nature of written speech texts; (2) discuss…

  10. Analysis of the reported symptoms that preceded the death of King Rajasinghe of Sithawake (1592 AD).

    Science.gov (United States)

    Veerasingam, Philip G

    2002-06-01

    A copy of an ola leaf manuscript, the original of which was written around the late 1590s, was published recently. It describes the sequence of events leading to the death of the warrior King Rajasinghe of the Sithawake Kingdom (1521-1593). A study of the contents of this letter is presented. The dressing applied to a wound on the foot of the King is described in that letter. It is likely that this dressing would have been an ideal medium to produce the highly potent tetanus exotoxin. The toxin would have diffused into the open wound and produced the sequence of symptoms and signs mentioned in the letter. An analysis of the symptoms and signs noted during the King's last illness as described in the letter is presented. Laryngospasm, and tonic and clonic spasms are easily identified. In addition, a group of symptoms attributed in the 1960s to sympathetic over-activity in tetanus are also recognisable. The conclusion is drawn that the King died of tetanus. The intriguing possibility of the wilful use of a lethal dressing on an open wound as a biological contact poison is left open for discussion.

  11. Errors Analysis of Solving Linear Inequalities among the Preparatory Year Students at King Saud University

    Science.gov (United States)

    El-khateeb, Mahmoud M. A.

    2016-01-01

    The purpose of this study aims to investigate the errors classes occurred by the Preparatory year students at King Saud University, through analysis student responses to the items of the study test, and to identify the varieties of the common errors and ratios of common errors that occurred in solving inequalities. In the collection of the data,…

  12. King Cotton's Lasting Legacy of Poverty and Southern Region Contemporary Conditions

    Science.gov (United States)

    Guthrie, James W.; Peevely, Gary

    2010-01-01

    One hundred fifty years ago, cotton was considered as the king of all United States' agricultural exports. Cotton's dollar value far exceeded that of any other mid-19th-century United States trade item, much more than tobacco, fish, forest products, raw materials for manufacturing, or manufactured items. Indeed, in the mid-19th century, cotton was…

  13. Fighting Fair. Dr. Martin Luther King, Jr. for Kids. Second Edition.

    Science.gov (United States)

    Schmidt, Fran; Friedman, Alice

    This curriculum guide for grades 4 through 9 uses the life and work of Dr. Martin Luther King, Jr., to teach conflict resolution and to explore the philosophy of non-violence for daily life. To enable students to learn and apply non-violence, it must be modeled in a classroom environment that builds trust and a sense of community. Each of the…

  14. Evaluating the Usability and Accessibility of LMS "Blackboard" at King Saud University

    Science.gov (United States)

    Alturki, Uthman T.; Aldraiweesh, Ahmed; Kinshuck

    2016-01-01

    King Saud University is in the process of adopting and implementing the interactive Blackboard Learning Management Systems (LMSs) with features that allow members of staff and teachers from different faculties to access, upload assignments, send quizzes, download content, and evaluate the academic progress of the members of faculty. However, many…

  15. Abuse of Power? : J. Edgar Hoover vs. Robert Kennedy and Martin Luther King, Jr.

    OpenAIRE

    Isaksen, Vigdis

    2002-01-01

    In this thesis I have looked at how J. Edgar Hoover came to power as Director of the FBI, and how he later used that power against Attorney General Robert Kennedy and SCLC leader Martin Luther King, Jr. I have further analyzed the reasons and motives for Hoover's actions by, among other things, making a psychological profile on the Director.

  16. Microbial Activity In The Peerless Jenny King Sulfate Reducing Bioreactors System

    Science.gov (United States)

    The Peerless Jenny King treatment system is a series of four sulfate reducing bioreactor cells installed to treat acid mine drainage in the Upper Tenmile Creek Superfund Site located in the Rimini Mining District, near Helena, MT. The system consists of a wetland pretreatment fo...

  17. Microbial Activity In The Peerless Jenny King Sulfate Reducing Bioreactor System (Presentation)

    Science.gov (United States)

    The Peerless Jenny King treatment system is a series of four sulfate reducing bioreactor cells installed to treat acid mine drainage in the Upper Tenmile Creek Superfund Site located in the Rimini Mining District, near Helena MT. The system consists of a wetland pretreatment fol...

  18. Pulpit Responses to Contemporary Issues: The On-Going Rhetoric of Dr. Martin Luther King.

    Science.gov (United States)

    Fadely, Dean; Greene, Ronald W.

    Many theoreticians have indicated that a major task of the nonpresumptive rhetor is to gain presumption, thereby shifting the burden of proof to the opposition. Rhetorically, Martin Luther King, Jr., sought to effect this shift in the burden of proof through the use of hierarchies of values. At the top of his value system was the love of God. The…

  19. Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

    NARCIS (Netherlands)

    Van Manen, Mirjam J G; Wapenaar, Monique; Strookappe, Bert; Drent, Marjolein; Elfferich, Marjon; De Vries, J.; Gosker, Harry R; Birring, Surinder S; Patel, Amit S; Van den Toorn, Leon; Van den Blink, Bernt; Boomars, Karin; Hoitsma, Elske; Wijsenbeek, Marlies S

    2016-01-01

    Background The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.Objective The aim of this study

  20. Conservative nutrient use by big-leaf mahogany (Swietenia macrophylla King) planted under contrasting environmental conditions

    Science.gov (United States)

    E. Medina; E. Cuevas; A.E. Lugo; E. Terezo; J. Jimenez-Osornio; P.A. Macario-Mendoza; P. Montanez

    2014-01-01

    We analyzed the nutritional composition and isotope ratios (C and N) of big-leaf mahogany (Swietenia macrophylla King) leaves in plantations established on contrasting soils and climates in Central America (State of Quintana Roo, Yucatan, Mexico) and South America (State of Para, Brazil). The objective was to determine the adaptability of this species to large...

  1. I Have a Dream: Martin Luther King, Jr. Handbook of Activities.

    Science.gov (United States)

    Duff, Ogle Burks, Ed.; Bowman, Suzanne H., Ed.

    This handbook is designed by teachers for teachers to share ideas and activities for celebrating the Martin Luther King holiday, as well as to teach students about other famous black leaders throughout the school year. The lesson plans and activities are presented for use in K-12 classrooms. Each lesson plan has a designated subject area, goals,…

  2. "The Lion King" and "Hamlet": A Homecoming for the Exiled Child.

    Science.gov (United States)

    Gavin, Rosemarie

    1996-01-01

    Explains how the movie "The Lion King" may be used to elucidate Shakespeare's "Hamlet," a play about a prince who does not always seem heroic to modern audiences. Gives specific points of comparison between the two works concerning heroes, characters, conflicts, themes, ending scenes, and archetypal patterns. (TB)

  3. Giving Peace a Chance: Gandhi and King in the English Classroom.

    Science.gov (United States)

    Gill, David

    2000-01-01

    Describes how one high school English teacher developed and taught a unit that would give students the opportunity to see how violence and nonviolence affects their lives. Notes the unit involves discussing the lives and careers of Mahatma Gandhi and Martin Luther King, Jr., viewing film clips and film, reading, writing in journals, and writing a…

  4. Abuse of Power? : J. Edgar Hoover vs. Robert Kennedy and Martin Luther King, Jr.

    OpenAIRE

    Isaksen, Vigdis

    2002-01-01

    In this thesis I have looked at how J. Edgar Hoover came to power as Director of the FBI, and how he later used that power against Attorney General Robert Kennedy and SCLC leader Martin Luther King, Jr. I have further analyzed the reasons and motives for Hoover's actions by, among other things, making a psychological profile on the Director.

  5. A fossil wood flora from King George Island: ecological implications for an Antarctic eocene vegetation

    NARCIS (Netherlands)

    Poole, I.J.; Hunt, Richard J.; Cantrill, David J.

    2001-01-01

    Early Tertiary sediments of the Antarctic Peninsula region continue to yield a rich assemblage of well-preserved fossil dicotyledonous angiosperm wood. The wood flora under consideration is from the Collins Glacier region on Fildes Peninsula, King George Island and is derived from tuffaceous

  6. If Dr. King Were a Principal: Building the "Beloved Community" in Schools

    Science.gov (United States)

    Hillis, Michael; Woolworth, Stephen

    2008-01-01

    In this article, the authors offer a more humanistic vision of educational community, one that is substantive in content yet flexible in its application to the diverse contexts in which American schooling occurs. In doing so, the authors turn specifically to the nonviolent philosophy of Dr. Martin Luther King, Jr. and consider what a school…

  7. "The Lion King" and "Hamlet": A Homecoming for the Exiled Child.

    Science.gov (United States)

    Gavin, Rosemarie

    1996-01-01

    Explains how the movie "The Lion King" may be used to elucidate Shakespeare's "Hamlet," a play about a prince who does not always seem heroic to modern audiences. Gives specific points of comparison between the two works concerning heroes, characters, conflicts, themes, ending scenes, and archetypal patterns. (TB)

  8. The King and Prisoner Puzzle: A Way of Introducing the Components of Logical Structures

    Science.gov (United States)

    Roh, Kyeong Hah; Lee, Yong Hah; Tanner, Austin

    2016-01-01

    The purpose of this paper is to provide issues related to student understanding of logical components that arise when solving word problems. We designed a logic problem called the King and Prisoner Puzzle--a linguistically simple, yet logically challenging problem. In this paper, we describe various student solutions to the puzzle and discuss the…

  9. Validation of the King's Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

    NARCIS (Netherlands)

    Van Manen, Mirjam J G; Wapenaar, Monique; Strookappe, Bert; Drent, Marjolein; Elfferich, Marjon; De Vries, J.; Gosker, Harry R; Birring, Surinder S; Patel, Amit S; Van den Toorn, Leon; Van den Blink, Bernt; Boomars, Karin; Hoitsma, Elske; Wijsenbeek, Marlies S

    2016-01-01

    Background The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.Objective The aim of this study w

  10. Examples of Mechanism Design: from King Solomon to eBay

    NARCIS (Netherlands)

    De Weerdt, M.M.

    2007-01-01

    The judgment of king Solomon is an early example of mechanism design. Mechanism design attempts to achieve desired outcomes in situations with self-interested players by setting the rules of the game in a specific way. We will see that the game Solomon proposed would not have worked if the women wer

  11. Metabolic response to lipid infusion in fasting winter-acclimatized king penguin chicks (Aptenodytes patagonicus).

    Science.gov (United States)

    Teulier, Loïc; Tornos, Jérémy; Rouanet, Jean-Louis; Rey, Benjamin; Roussel, Damien

    2013-05-01

    During the cold austral winter, king penguin chicks are infrequently fed by their parents and thus experience severe nutritional deprivation under harsh environmental conditions. These energetic constraints lead to a range of energy sparing mechanisms balanced by the maintenance of efficient thermogenic processes. The present work investigated whether the high thermogenic capacities exhibited by winter-acclimatized king penguin chicks could be related to an increase in lipid substrate supply and oxidation in skeletal muscle, the main site of thermogenesis in birds. To test this hypothesis, we examined i) the effect of an experimental rise in plasma triglyceride on the whole metabolic rate in winter-acclimatized (WA) and de-acclimatized king penguin chicks kept at thermoneutrality (TN), and ii) investigated the fuel preference of muscle mitochondria. In vivo, a perfusion of a lipid emulsion induced a small 10% increase of metabolic rate in WA chicks but not in TN group. In vitro, the oxidation rate of muscle mitochondria respiring on lipid-derived substrate was +40% higher in WA chicks than in TN, while no differences were found between groups when mitochondria oxidized carbohydrate-derived substrate or succinate. Despite an enhanced fuel selection towards lipid oxidation in skeletal muscle, a rise of circulating lipids per se was not sufficient to fully unravel the thermogenic capacity of winter-acclimatized king penguin chicks.

  12. Racism and the Older Voter? Arizona's Rejection of a Paid Holiday to Honor Martin Luther King.

    Science.gov (United States)

    Kastenbaum, Robert

    1991-01-01

    Questions whether defeat of propositions to establish paid Martin Luther King holiday in Arizona was example of racism among primarily White senior adult voters of the state. Proposes three models to account for general pattern of election-related behavior and for vote itself: proactive racist; pragmatic self-interest; and fortress mentality.…

  13. Martin Luther King, Jr.'s "Beloved Community" Ideal and the Apartheid System in South Africa.

    Science.gov (United States)

    Baldwin, Lewis V.

    1986-01-01

    King's comments and opinions on the following aspects of South African apartheid are presented: (1) similarities to and differences from America's racist system; (2) the role of western countries and their pressure; (3) the role of black Americans; (4) the role of multi-racial coalitions; and (5) the role of religious groups. (PS)

  14. A fossil wood flora from King George Island: ecological implications for an Antarctic eocene vegetation

    NARCIS (Netherlands)

    Poole, I.J.; Hunt, Richard J.; Cantrill, David J.

    2001-01-01

    Early Tertiary sediments of the Antarctic Peninsula region continue to yield a rich assemblage of well-preserved fossil dicotyledonous angiosperm wood. The wood flora under consideration is from the Collins Glacier region on Fildes Peninsula, King George Island and is derived from tuffaceous sedimen

  15. Critical Discourse Analysis of Martin Luther King's Speech in Socio-Political Perspective

    Science.gov (United States)

    Sipra, Muhammad Aslam; Rashid, Athar

    2013-01-01

    The article presents the Critical Discourse Analysis (CDA) of the first part of King Martin Luther's speech "When I Have a Dream" in socio-political context. The study investigates how it lies on the basis of application of Fairclough version of CDA in the first part of the text. Moreover, it explicates the terms like social, cultural…

  16. "I Have a Dream, Too!": The American Dream in Coretta Scott King Award-Winning Books

    Science.gov (United States)

    Parsons, Linda T.; Castleman, Michele

    2011-01-01

    The Coretta Scott King (CSK) Award, instituted in 1969 and recognized as an official award by the American Library Association (ALA) in 1982, is conferred annually to an African American author and an illustrator for their outstanding contributions to literature about the Black experience for children and young adults. A partial impetus for the…

  17. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    Science.gov (United States)

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  18. Utilidade e significância social da teoria do alcance de metas de king

    Directory of Open Access Journals (Sweden)

    Inácia Sátiro Xavier de França

    2002-02-01

    Full Text Available Esta pesquisa enfocou o modelo de análise de teorias de Meleis, a Teoria do Alcance de Objetivos (King, 1981 e um estudo realizado por Silveira, objetivando analisar a utilidade e significância social da Teoria de King. Realizamos uma leitura compreensiva da Teoria de King e do modelo proposto por Meleis. Recortamos, desse modelo, o segmento "Crítica de teoria" para servir de suporte analítico. Selecionamos o estudo "Estar despido na unidade de terapia intensiva: duas percepções e um encontro" (Silveira, 1996, cujo marco teórico é a teoria supracitada. Da análise crítica, apoiada na inter-relação desses construtos, concluímos que: a teoria de King é útil à pesquisa por possibilitar a percepção e a interpretação dos dados objetivo-subjetivos da realidade concreta. Sua significância social tem relação com a aplicação da teoria por representantes dos vários segmentos sociais, viabilizando a re-socialização de pessoas e grupos em prol de um mundo mais humano, solidário, cidadão.

  19. Martin Luther King, 40 ans après sa disparition

    Directory of Open Access Journals (Sweden)

    Hélène Harter

    2009-01-01

    Full Text Available Le 4 avril 1968 Martin Luther King est assassiné à Memphis. Moins de cinq ans après la mort du président Kennedy, les Etats-Unis sont à nouveau touchés par la violence politique. Cet article retrace le parcours qui a conduit le révérend King jusqu’à Memphis en cette année politiquement et socialement agitée. Comment sa mort est-elle vécue aux États-Unis ? Quelle mémoire conserve-t-on de lui aujourd’hui ?On April 4, 1968 Martin Luther King was assassinated in Memphis. Less than five years after the death of President Kennedy, the United States were affected again by political violence. This article explains why Rev. King went to Memphis during this politically and socially troubled year. How his death has been perceived in the United States? Does his legacy still live on forty years after his death?

  20. Martin Luther King, Jr.: A Lesson with Interdisciplinary Connections for Middle-Level Music Students.

    Science.gov (United States)

    Early, Mary Frances; Terry, Cynthia

    This lesson begins with a very brief biography of Martin Luther King, Jr. The lesson identifies its educational objectives; addresses National Standards for Music Education; lists materials needed; details six step-by-step classroom procedures for lesson implementation; and provides curriculum connections for language arts, visual art, physical…

  1. Siim Nestor soovitab : Goldie. Kevin Saunderson. Nicole Willis. King Britt / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2005-01-01

    Popmuusikaüritustest: briti muusik Goldie esineb jungle-muusikaga Tallinnas 21. apr. klubis Privé, DJ Kevin Saunderson 22. apr. klubis Privé, laulja Nicole Willis 27. apr. BonBon Jazz Lounge'il klubis BonBon, Philadelphia muusik King Britt ja Eesti ansambel Broken Time Orchestra esitlevad oma heliplaate

  2. The Rhetorical Construction of Time in Martin Luther King, Jr.'s "Letter from Birmingham Jail."

    Science.gov (United States)

    Lee, Ronald E.

    1991-01-01

    Explores the rhetorical use of time in Martin Luther King, Jr.'s "Letter from Birmingham Jail." Offers an explanation of the ideological heritage that temporarily unifies the discourse. Describes the letter's recent, historical, and spiritual time frames, accounts for the ideological purpose each serves, and explains on what ground they…

  3. The Fierce Urgency of now: Honoring Martin Luther King, Jr. in and out of the Classroom.

    Science.gov (United States)

    Kazemek, Francis E.

    1988-01-01

    Explores how educators and their students can best honor Martin Luther King, Jr.'s, memory by using his life and works as a catalyst for acting upon school and society in a way that fosters social change. (Author/BJV)

  4. Endotracheal Intubation Using the Macintosh Laryngoscope or KingVision Video Laryngoscope during Uninterrupted Chest Compression

    Directory of Open Access Journals (Sweden)

    Ewelina Gaszynska

    2014-01-01

    Full Text Available Objective. Advanced airway management, endotracheal intubation (ETI, during CPR is more difficult than, for example, during anesthesia. However, new devices such as video laryngoscopes should help in such circumstances. The aim of this study was to assess the performance of the KingVision video laryngoscopes in a manikin cardiopulmonary resuscitation (CPR scenario. Methods. Thirty students enrolled in the third year of paramedic school took part in the study. The simulated CPR scenario was ETI using the standard laryngoscope with a Macintosh blade (MCL and ETI using the KingVision video laryngoscope performed during uninterrupted chest compressions. The primary endpoints were the time needed for ETI and the success ratio. Results. The mean time required for intubation was similar for both laryngoscopes: 16.6 (SD 5.11, median 15.64, range 7.9–27.9 seconds versus 17.91 (SD 5.6, median 16.28, range 10.6–28.6 seconds for the MCL and KingVision, respectively (P=0.1888. On the first attempt at ETI, the success rate during CPR was comparable between the evaluated laryngoscopes: P=0.9032. Conclusion. The KingVision video laryngoscope proves to be less superior when used for endotracheal intubation during CPR compared to the standard laryngoscope with a Mackintosh blade. This proves true in terms of shortening the time needed for ETI and increasing the success ratio.

  5. The Rhetoric of Martin Luther King, Jr.: Letter from Birmingham Jail

    Science.gov (United States)

    Mott, Wesley T.

    1975-01-01

    Argues that the success of 'The Letter' can be attributed to the confluence of three distinct rhetorical traits: King's heritage of the highly emotional Negro preaching tradition, his shrewd sense of political timing and polemical skill, and his conscious literary ability, and notes that 'The Letter' is one of the most frequently collected items…

  6. Monkey-King immune evolutionary algorithm%猴王免疫进化算法

    Institute of Scientific and Technical Information of China (English)

    邹艳玲; 吴启满; 李育强; 王兵

    2011-01-01

    猴王遗传算法具有原理简单、易于计算的优点,但存在猴王点(最优个体)附近空间局部寻优能力弱,进而影响全局搜索能力的局限.通过引入免疫进化算法,对猴王点进行免疫进化迭代优化,使得既加大对最优个体附近解空间搜索的同时,也兼顾了对最优个体附近解空间以外区域的搜索,避免了不成熟收敛;且随着迭代的进行,局部搜索能力不断得到加强,算法以更高的精度逼近全局最优解.对多个典型测试函数的计算,并与猴王遗传算法、改进后的猴王遗传算法和普通爬山算子遗传算法的优化计算结果进行了比较.结果表明猴王免疫进化算法具有更佳的寻优能力和更好的稳定性.%Monkey-King genetic algorithm has the shortages of the lower searching ability in the local area and further in the whole area at monkey-king point, in spite of the advantages of the simple principle and simplicity in calculation. Monkey-king point was optimized iteratively by using immune evolutionary algorithm. This method overcomes the premature convergence because of the optimal searching in the out as well as in of the areas at the monkey-king point. At the same time, with the process of iteration, the algorithm closes in the whole of optimal solution with the higher precision because of the gradual strengthening of local searching ability. This paper calculates typical test function and compares with several methods, such as monkey-king genetic algorithm, improved monkey-king genetic algorithm and common climbing operator genetic algorithm et al. The results show that the monkey-king immune evolutionary algorithm has the optimal searching ability and the better stability.

  7. Biohistorical materials and contemporary privacy concerns-the forensic case of King Albert I.

    Science.gov (United States)

    Larmuseau, Maarten H D; Bekaert, Bram; Baumers, Maarten; Wenseleers, Tom; Deforce, Dieter; Borry, Pascal; Decorte, Ronny

    2016-09-01

    The rapid advancement of technology in genomic analysis increasingly allows researchers to study human biohistorical materials. Nevertheless, little attention has been paid to the privacy of the donor's living relatives and the negative impact they might experience from the (public) availability of genetic results, even in cases of scientific, forensic or historical relevance. This issue has become clear during a cold case investigation of a relic attributed to Belgian King and World War I-hero Albert I who died, according to the official version, in a solo climbing accident in 1934. Authentication of the relic with blood stains assigned to the King and collected on the place where his body was discovered is recognised as one of the final opportunities to test the plausibility of various conspiracy theories on the King's demise. While the historical value and current technological developments allow the genomic analysis of this relic, publication of genetic data would immediately lead to privacy concerns for living descendants and relatives of the King, including the Belgian and British royal families, even after more than 80 years. Therefore, the authentication study of the relic of King Albert I has been a difficult exercise towards balancing public research interests and privacy interests. The identification of the relic was realised by using a strict genetic genealogical approach including Y-chromosome and mitochondrial genome comparison with living relatives, thereby limiting the analysis to genomic regions relevant for identification. The genetic results combined with all available historical elements concerning the relic, provide strong evidence that King Albert I was indeed the donor of the blood stains, which is in line with the official climbing accident hypothesis and contradicts widespread 'mise-en-scène' scenarios. Since publication of the haploid data of the blood stains has the potential to violate the privacy of living relatives, we opted for

  8. FERMENTATION QUALITY OF KING GRASS SILAGE TREATED WITH LIQUID OR DRIED INOCULANT OF LACTIC ACID BACTERIA

    Directory of Open Access Journals (Sweden)

    B. Santoso

    2016-03-01

    Full Text Available The aim of this study was to evaluate the nutritive value and fermentation characteristic of king grass silage treated with addition of liquid or dried lactic acid bacteria (LAB inoculant. Experiment was arranged to a completely randomized design with four treatments and three replications. Four treatments as follows (A king grass without LAB inoculant as the control; (B king grass + 30 ml of liquid of epiphytic LAB inoculant/kg of fresh forage; (C king grass + 30 g of freeze-dried powder of LAB inoculant/kg of fresh forage; (D king grass + 30 g of centrifuged powder of LAB inoculant/kg of fresh forage. The liquid LAB inoculant was sprayed on the top of grass and then mannualy mixed by hand. The intial LAB concentration in all inoculants were 1.0 × 106 cfu/g. About 500 g of silage materials were ensiled into plastic silos and stored at room temperatures (approximately 28oC for 30 days. Results showed that pH value, concentrations of lactic acid, N-amonia (NH3-N, butyric acid and total volatile fatty acids (VFA as well as Fleigh Point were affected by treatment of LAB inoculant. Silage treated with liquid or dried of LAB inoculant had lower (P<0.01 pH value compared to the control silage. Concentrations of NH3-N and butyric acid significantly decreased (P<0.01 in silage treated with LAB inoculants. Silage treated with centrifuged powder of LAB inoculant had the highest (P<0.05 Fleigh Point than other silage. In vitro neutral detergent fiber (NDF digestibility was significantly higher (P<0.05 in silage treated with LAB inoculant compared to the control silage.

  9. Dr Julia King CBE FREng, Chief Executive Designate, Institute of Physics (United Kingdom), visiting the NA48 experiment.

    CERN Document Server

    Patrice Loïez

    2002-01-01

    Photo 02: Visiting the NA48 experiment, Dr Julia King, Chief Executive Designate, Institute of Physics (Britain and Ireland) (right) with A. Ceccucci and K. Peach. Photo 05: Visiting the NA48 experiment, Dr Julia King, Chief Executive Designate, Institute of Physics (Britain and Ireland) (centre) with A. Ceccucci and C. Lazzeroni. Photo 08: Visiting the NA48 experiment, Dr Julia King, Chief Executive Designate, Institute of Physics (Britain and Ireland) (second from left) with (left to right) R. Barlow, J. Wood, N. McCubbin, K. Peach, A. Ceccucci, C. Lazzeroni, M. Patel and D. Munday.

  10. Monarchical Activities of the Yoruba Kings of South Western Nigeria: A Cultural Heritage in Printmaking Visual Documentary.

    OpenAIRE

    2014-01-01

    Printmaking is a visual documentary media of art which was used as a medium of expression in analyzing myth and mythology monarchical activities of the Yorubas in South Western Nigeria in this study. The  monarchical activities of the Yoruba Kings, is  the cultural heritage and legacy that people do guide jealously and considered to be of high cultural value. The Yoruba Kings of South Western Nigeria are traditional entity which passed through the rites of installing kings for the throne fore...

  11. King-Werner法求解高阶奇异问题%King-Werner Method for Solving High Order Singular Problems

    Institute of Scientific and Technical Information of China (English)

    龙海波; 孙伟; 姜福全

    2009-01-01

    近年来,有许多实际问题的解决都可归结为高阶奇异非线性方程组的求解,因而引起了人们的兴趣.本文考虑用King-Werner法yn+1=yn-F′((xn+yn)/(2))-1F(yn),xn+1=yn+1-F′((xn+yn)/(2))-1F(yn+1).(1)求解高阶奇异问题.

  12. AFSC/RACE/SAP/Daly:Juvenile blue king crab cannibalism experiment conducted in the Kodiak Lab in 2014

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is part of a laboratory experiment, which evaluated how varying prey densities (year-0 blue king crabs) and habitat type (shell and sand) affect the...

  13. Copper and Other Contaminants in King's Bay and Crystal River (Florida) Sediments: Implications for Impact on the West Indian Manatee

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Contaminant concentrations were measured in 25 sediment samples collected from King's Bay, the headwaters of the Crystal River, Florida. Total organic carbon content...

  14. Compreensão do modelo de king sobre o paradigma do Interacionismo Simbólico Entendiendo el modelo de king en el paradigma del Interaccionismo Simbolico Understanding of king's model on the paradigm of Simbolic Interactionism

    Directory of Open Access Journals (Sweden)

    Iliana Maria de Almeida Araújo

    2005-12-01

    Full Text Available Objetivou-se refletir sobre o modelo conceitual de King, segundo a abordagem do Interacionismo Simbólico, dentro do modelo de análises de teoria de Meleis. Para alcançar o objetivo, realizamos uma leitura dos três modelos citados nos trabalho, buscando as congruências e discrepâncias entre os conceitos e correlacionando-os. O estudo permitiu concluir que as teorias concordam ao elucidar o homem como um ser que reage e busca compreender o significado das coisas ao seu redor, planejando e julgando suas ações e a dos outros. É importante a questão dos significados poderem ser modificados e gerarem a elaboração de metas em comum.Se apuntó a reflectir acerca del modelo conceptual de King, según el acercamiento de Interacionismo Simbólico, dentro del modelo de análisis de la teoría de Meleis. Para alcanzar el objetivo, nosotros logramos una lectura de los tres modelos mencionada en el trabajo, mientras buscando las consistencias y diferencias entre los conceptos y poniéndolos en correlación. El estudio permitió concluir que las teorías están de acuerdo al elucidar al hombre como un ser que reacciona e investiga para entender el significado de las cosas en suyo circuito, mientras flotando y juzgando sus acciones y el uno de los otros. Es importante el asunto de los significados podría modificarse y ellos generan la elaboración de metas en común.It was aimed to reflect on King's Theory, according to the approach of Symbolic Interaccionism, and theory analyses model of Meleis. To reach the objective, we proceeded the reading of the three models as mentioned before, looking for the consistencies and discrepancies among the concepts and correlating them. The study allowed to conclude that the theories agree when elucidating the man as a being that reacts and search to understand the meaning of things to his/her circuit, drifting and judging their actions and the one of the other ones. It is important the subject of the meanings

  15. Implementing e-resource access for alumni at King's College London: a case study

    Directory of Open Access Journals (Sweden)

    Anna França

    2014-11-01

    Full Text Available University libraries are increasingly considering ways to develop the library services offered to their alumni in response to growing demand. In particular, there has been a rising interest in how university libraries can extend access to e-resources to include provision of access for alumni, raising a number of challenging questions around the licensing of e-resources for alumni as well as access and funding considerations. This article describes the work carried out at King's College London to investigate extending e-resource access to alumni and the experience of implementing access to JSTOR in 2012. The article then examines some of the barriers that King's have faced in building on this work.

  16. Novel Eimeria sp. isolated from a King's skink (Egernia kingii) in Western Australia.

    Science.gov (United States)

    Yang, Rongchang; Brice, Belinda; Bennett, Mark D; Eliott, Aileen; Ryan, Una

    2013-02-01

    A novel Eimeria sp. was identified in faeces collected from a King's skink (Egernia kingii) housed at the Kanyana Wildlife Rehabilitation Centre in Western Australia. Oocysts measure 17.0×15.0 μm with a length/width ratio (L/W) of 1.13. Phylogenetic analysis of 18S rRNA sequences indicated that the novel Eimeria sp. shared the highest genetic similarity to Eimeria antrozoi and Eimeria rioarribaensis from vespertilionid bats from North America (≥98.9%). At the COI locus, bat-derived sequences were not available and phylogenetic analysis placed the novel Eimeria sp. in a clade by itself and shared 98.8% similarity with the rodent-derived species E. falciformis and E. vermiformis. This suggests that the isolate from the King's skink's faeces was probably derived from a mammal, possibly a rodent or a bat.

  17. Racism and the older voter? Arizona's rejection of a paid holiday to honor Martin Luther King.

    Science.gov (United States)

    Kastenbaum, R

    1991-01-01

    Two propositions that would have established a paid Martin Luther King holiday were defeated in Arizona's statewide elections of November 6, 1990. Communities and counties with high proportions of senior adult voters cast proportionately more votes against these propositions. Was this an example of racism among the primarily anglo senior adult voters of Arizona? Three models were proposed to account for the general pattern of election-related behavior as well as the vote itself: 1) proactive racist, 2) pragmatic self-interest, and 3) fortress mentality. It was suggested that proactive racism and pragmatic self-interest accounted for less of the opposition to a paid holiday honoring Martin Luther King than did a fortress mentality that has developed through a combination of circumstances. Attention is also given to the larger question of senior adults as perpetrators as well as victims of bigotry.

  18. Isolation and identification of lactid acid bacteria originated from king grass (Pennisetum purpureophoides) as candidate of probiotic for livestock

    OpenAIRE

    Santoso B; Maunatin A; Hariadi BT; Abubakar H

    2013-01-01

    A study was conducted to isolate and identify strain of lactic acid bacteria (LAB) isolated from king grass, and to determine their potential as candidate of probiotic for livestock. The LAB was isolated by culturing king grass extract in De Man, Rogosa and Sharpe (MRS) medium. The pure culture LAB was used to identify strain of bacteria using Analytical Profile Index (API) 50 CH kit. The result showed that the strain bacteria was identified as Lactobacillus plantarum. L. plantarum was able t...

  19. At?sea distribution and habitat use in king penguins at sub?Antarctic Marion Island

    OpenAIRE

    Pistorius, Pierre; Hindell, Mark; Crawford, Robert; Makhado, Azwianewi; Dyer, Bruce; Reisinger, Ryan

    2017-01-01

    Abstract King penguins make up the bulk of avian biomass on a number of sub?Antarctic islands where they have a large functional effect on terrestrial and marine ecosystems. The same applies at Marion Island where a substantial proportion of the world population breeds. In spite of their obvious ecological importance, the at?sea distribution and behavior of this population has until recently remained entirely unknown. In addressing this information deficiency, we deployed satellite?linked tra...

  20. Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors.

    Science.gov (United States)

    Sivasothy, Yasodha; Krishnan, Thiba; Chan, Kok-Gan; Abdul Wahab, Siti Mariam; Othman, Muhamad Aqmal; Litaudon, Marc; Awang, Khalijah

    2016-03-21

    Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.

  1. Reconciling PM10 analyses by different sampling methods for Iron King Mine tailings dust.

    Science.gov (United States)

    Li, Xu; Félix, Omar I; Gonzales, Patricia; Sáez, Avelino Eduardo; Ela, Wendell P

    2016-03-01

    The overall project objective at the Iron King Mine Superfund site is to determine the level and potential risk associated with heavy metal exposure of the proximate population emanating from the site's tailings pile. To provide sufficient size-fractioned dust for multi-discipline research studies, a dust generator was built and is now being used to generate size-fractioned dust samples for toxicity investigations using in vitro cell culture and animal exposure experiments as well as studies on geochemical characterization and bioassay solubilization with simulated lung and gastric fluid extractants. The objective of this study is to provide a robust method for source identification by comparing the tailing sample produced by dust generator and that collected by MOUDI sampler. As and Pb concentrations of the PM10 fraction in the MOUDI sample were much lower than in tailing samples produced by the dust generator, indicating a dilution of Iron King tailing dust by dust from other sources. For source apportionment purposes, single element concentration method was used based on the assumption that the PM10 fraction comes from a background source plus the Iron King tailing source. The method's conclusion that nearly all arsenic and lead in the PM10 dust fraction originated from the tailings substantiates our previous Pb and Sr isotope study conclusion. As and Pb showed a similar mass fraction from Iron King for all sites suggesting that As and Pb have the same major emission source. Further validation of this simple source apportionment method is needed based on other elements and sites.

  2. Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors

    Directory of Open Access Journals (Sweden)

    Yasodha Sivasothy

    2016-03-01

    Full Text Available Malabaricones A–C (1–3 and giganteone A (4 were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4 as a suitable anti-quorum sensing agent was demonstrated.

  3. TERPENOS Y FLAVONOIDES DE Ageratina fastigiata (H.B.K. King & Robinson

    Directory of Open Access Journals (Sweden)

    Ruben Torrenegra G.

    2010-09-01

    Full Text Available De los extractos lipofílicos tanto de hojas como de flores, se aislaron e identificaron dos derivados del kaurano: el ent-kauran-16B-ol y el entkauran-] 6,20-diol y, dos flavonas metoxiladas: la 5-hidroxi-7,4' dimetoxiflavona y la 5-hidroxi-3,7,4'-trimetoxi-flavona, Los dos diterpenos confirman la ubicación taxonómica de dicha especie según King y Robinson.

  4. Impact of Foreign-Born Persons on HIV Diagnosis Rates among Blacks in King County, Washington

    Science.gov (United States)

    Kent, James B.

    2005-01-01

    To characterize HIV and AIDS cases in foreign-born persons in King County, Washington, HIV surveillance data were analyzed by place of birth, race and ethnicity, mode of transmission, and year of HIV diagnosis. The proportion of new HIV diagnoses among foreign-born Blacks increased from 3.5% during the 3-year period from 1995 to 1997 to 7.5%…

  5. La nación Latin Kings, desafíos para repensar lo nacional

    Directory of Open Access Journals (Sweden)

    Mauro Cerbino Ana Rodríguez

    2010-04-01

    Full Text Available En contra de visiones de la criminología positivista y las perspectivas securitarias, que reducen la organización Latin Kings a un fenómeno de pandillerismo, es decir, como formación juvenil desviada, esta investigación indaga en las condiciones históricas, sociales y culturales que han posibilitado el surgimiento de este grupo y su permanencia en contextos de profundas desigualdades y exclusiones.

  6. Using King's interacting systems theory to link emotional intelligence and nursing practice.

    Science.gov (United States)

    Shanta, Linda L; Connolly, Maria

    2013-01-01

    King's theory is a broad theory designed to provide a framework for nursing (I.M. King, 1981), whereas emotional intelligence (EI; J.D. Mayer & P. Salovey, 2004) is a theory that is specific for addressing potential competency in dealing with emotions and emotional information. J.D. Mayer, P. Salovey, D.R. Caruso, and G. Sitarenios (2001) defined EI as the "ability to recognize the meaning of emotions and their relationships and to use them as a basis for reasoning and problem solving" (p. 234). These researchers believed that EI is related to cognitive intellect through the ability to use reasoning by way of information to find meaning. J.D. Mayer and P. Salovey (2004) argued that the skills that comprise EI were likely enhanced through obtaining a liberal education infused with values exploration. J.D. Mayer, P. Salovey, D.R. Caruso, and G. Sitarenios (2001) contended that there are 4 branches of abilities that create EI: (a) the skill of perceiving emotion within oneself and others, (b) assimilation of an emotion to facilitate thinking, (c) understanding and knowledge of emotion, and (d) conscious regulation of emotion. Each level or branch builds upon the previous one, and awareness of what each branch offers the individual in enhancing relationships with others is a key component of healthy emotional interactions. This article will provide a theoretic foundation based upon King's interacting systems theory (IST; 1981) that embraces EI as a crucial component in the nurse's ability to provide holistic care for patients, peers, and themselves. King's IST underscores the necessity of nurses possessing abilities of EI as they care for others but does not fully describe a mechanism to understand and incorporate emotions within the complex nurse-patient interactions and communications that are part of the nursing process. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Scholarly communications a history from content as king to content as kingmaker

    CERN Document Server

    Regazzi, John J

    2015-01-01

    Scholarly Communications: A History from Content as King to Content as Kingmaker traces the development of scholarly communications from the creation of the first scientific journal through the wide diversity of professional information services today. Unlike any other book, this work is an authoritative history by the past President of Elsevier and current Professor at Long Island University, which examines the changing nature of scholarly communication throughout its history, including its research importance as well as its business value.

  8. Are dragon-king neuronal avalanches dungeons for self-organized brain activity?

    Science.gov (United States)

    de Arcangelis, L.

    2012-05-01

    Recent experiments have detected a novel form of spontaneous neuronal activity both in vitro and in vivo: neuronal avalanches. The statistical properties of this activity are typical of critical phenomena, with power laws characterizing the distributions of avalanche size and duration. A critical behaviour for the spontaneous brain activity has important consequences on stimulated activity and learning. Very interestingly, these statistical properties can be altered in significant ways in epilepsy and by pharmacological manipulations. In particular, there can be an increase in the number of large events anticipated by the power law, referred to herein as dragon-king avalanches. This behaviour, as verified by numerical models, can originate from a number of different mechanisms. For instance, it is observed experimentally that the emergence of a critical behaviour depends on the subtle balance between excitatory and inhibitory mechanisms acting in the system. Perturbing this balance, by increasing either synaptic excitation or the incidence of depolarized neuronal up-states causes frequent dragon-king avalanches. Conversely, an unbalanced GABAergic inhibition or long periods of low activity in the network give rise to sub-critical behaviour. Moreover, the existence of power laws, common to other stochastic processes, like earthquakes or solar flares, suggests that correlations are relevant in these phenomena. The dragon-king avalanches may then also be the expression of pathological correlations leading to frequent avalanches encompassing all neurons. We will review the statistics of neuronal avalanches in experimental systems. We then present numerical simulations of a neuronal network model introducing within the self-organized criticality framework ingredients from the physiology of real neurons, as the refractory period, synaptic plasticity and inhibitory synapses. The avalanche critical behaviour and the role of dragon-king avalanches will be discussed in

  9. [Ophthalmology in the ancient river cultures. Was cataract surgery performed during the time of King Hammurabi?].

    Science.gov (United States)

    Bieganowski, Lech

    2003-01-01

    The article presents the state of ophthalmological knowledge in the Ancient River Cultures. Medical and ophthalmological information included in King Hammurabi Code is discussed. The author presents a critical analysis of the views related to the hypothesis of possible performance of cataract operation in Babylon during the Hammurabi period. Terminological and medical matters related to this issue are discussed. The original opinion about surgical treatment of symblepharon or pannus trachomatosus is presented.

  10. Terpenos y flavonoides de ageratina fastigiata (H.B.K. King & Robinson

    Directory of Open Access Journals (Sweden)

    Rubén Torrenegra G.

    2010-07-01

    Full Text Available De los extractos lipofílicos tanto de hojas como de flores, se aislaron e identificaron dos derivados del kaurano: el ent-kauran-16B-ol y el entkauran-] 6,20-diol y, dos flavonas metoxiladas: la 5-hidroxi-7,4'-dimetoxiflavona y la 5-hidroxi-3,7,4'-trimetoxi-flavona, Los dos diterpenos confirman la ubicación taxonómica de dicha especie según King y Robinson.

  11. Hydrography of Potter Cove, a Small Fjord-like Inlet on King George Island (South Shetlands)

    Science.gov (United States)

    Klöser, Heinz; Ferreyra, Gustavo; Schloss, Irene; Mercuri, Guillermo; Laturnus, Frank; Curtosi, Antonio

    1994-05-01

    The hydrography of Potter Cove (King George Island, South Shetlands) is described in detail for one summer season. Recorded data are wind, air temperature, water temperature, salinity and water colour. From these, information on surface circulation patterns and dynamics of suspended sediments are derived. Possible sources of sediment input are discussed. As a result, a complex interaction between wind forcing, circulation and seasonal melt of high glacier surfaces emerges.

  12. King Lear’s“look with thine ears”and Shakespeare’s Grammar School Training

    Institute of Scientific and Technical Information of China (English)

    牛颖

    2014-01-01

    About Shakespeare’s classic learning, Ben Jonson’s“small Latin and less Greek”has long been regarded precise and pertinent. This essay, however, is to explore the other part of the picture. In King Lear, Shakespeare has shown adroit application of Elizabethan rhetoric devices like hypallage, polyptoton and anadiplosis. It denotes his somewhat rigid grammar school training especially in oratory, which partly explains his classism.

  13. Oedipus The King by Sophocles and Seneca – The Cultural, Historical and Individual Aspects of Hermeneutics

    OpenAIRE

    Brane Senegačnik

    2010-01-01

    A comparison between Sophocles’ and Seneca’s Oedipus the King affords large scope for illuminating the similarities and contrasts between their respective cultural milieus. The generic and thematic similarity of the works (which, of course, points to the embeddedness of Roman drama in the Greek genre) helps to set off the enormous cultural differences: the social function of the theatre, the conception of myth, and the religious and spiritual horizons in the early Roman Empire vastly differed...

  14. The myth of king Oedipus versus the "Molinism" of Corneille's great tragedies

    OpenAIRE

    Boštjan Marko Turk

    2015-01-01

    he article tries to shed light on the internal dynamics in the plays by Pierre Corneille. As a comparative basis it uses the story about king Oedipus as it was first presented by Sophocles. In this connection it researches the role of coincidence or hamartia, as defined by Aristotle and comes to the conclusion that coincidence has an important role in the genesis of the great tragedies, although it is not so explicit as with Sophocles.

  15. Dysmenorrhea among female medical students in King Abdulaziz University: Prevalence, Predictors and outcome

    OpenAIRE

    Ibrahim, Nahla Khamis; AlGhamdi, Manar Saleh; Al-Shaibani, Alanoud Nawaf; AlAmri, Fatima Ali; Alharbi, Huda Abdulrahman; Al-Jadani, Arwa Kheder; Alfaidi, Raghad Ahmed

    2015-01-01

    Objective: To determine the prevalence, predictors and outcome of dysmenorrhea among female medical students in King Abdulaziz University (KAU), Jeddah, Saudi Arabia. Methods: A cross-sectional study was conducted among 435 medical students at KAU, Jeddah selected through stratified random sample method. A pre-constructed, validated, self-administered questionnaire was used to collect personal and socio-demographic information. Data about menstrual history, stress, smoking were also collected...

  16. Cicero's de legibus and Martin Luther King, Jr.’s Stride toward freedom

    Directory of Open Access Journals (Sweden)

    Boleslav s. Povšič

    1979-12-01

    Full Text Available He who reads carefully Cicero'sDe Legibus and Martin Luther King, Jr.'s Stride Toward Freedom is surprised to find, mutatis mutandis, on how many points these two great men agree. The historical circumstances are different, but the essential ideas are very similar. The purpose of this paper is to show on what precisely they agree and on what they differ.

  17. KingSCADA与液位仪的通讯设计

    Institute of Scientific and Technical Information of China (English)

    冯宏伟

    2014-01-01

    液位仪是一种对大型储油罐参数进行实时监测的设备,利用KingSCADA上位软件实现对油罐数据的监控。本文设计了基于visual studio 2010平台的液位仪设备接口的驱动开发,从而实现油罐最优化的管理。

  18. ATTITUDES OF MEDICAL LABORATORY TECHNOLOGY GRADUATES TOWARDS THE INTERNSHIP TRAINING PERIOD AT KING FAISAL UNIVERSITY

    OpenAIRE

    Bashawri, Layla A.M.; Mirghani A Ahmed; Bahnassy, Ahmed A.L.; Al-Salim, Jawaher A.

    2006-01-01

    Objectives: The objective of this present survey was to look into the attitudes of medical laboratory technology (MLT) graduates towards the internship training period of the MLT Department, College of Applied Medical Sciences, King Faisal University. Material and Methods: A self-administered questionnaire was designed and distributed for this purpose. The study period was from December 1st 2002 – 31st December 2004. Two-hundred questionnaires were distributed to recent graduates, and 115 wer...

  19. Regional variation in bycatches associated with king scallop (Pecten maximus L.) dredge fisheries.

    Science.gov (United States)

    Szostek, Claire L; Murray, Lee G; Bell, Ewen; Lambert, Gwladys; Kaiser, Michel J

    2017-02-01

    The biomass and composition of bycatch from king scallop dredge fisheries was assessed and compared between the English Channel, Cardigan Bay in Wales and around the Isle of Man. Bycatch composition varied significantly at localised, and broad, geographic scales. The mean proportion of scallop dredge bycatch biomass in the English Channel was 19% of total catch biomass. The proportion of bycatch was lower in Cardigan Bay (15%) but notably higher around the Isle of Man (53%). The proportion of individual bycatch species in dredge catches were low, therefore scallop dredging is unlikely to cause a substantial increase the population mortality of individual commercially fished species beyond that caused by the target fisheries for those species, or bycatches of other fisheries. The amount and mortality of organisms left on the seabed in the dredge path was not quantified in this study but should also be considered in management of the fishery. The discard rate of finfish and shellfish of commercial value from the king scallop dredge fishery in the English Channel was between 18 and 100%, with a higher rate of discarding occurring in the eastern English Channel compared to the west. The clear regional differences in bycatch composition and variation in the quantity of discards mean that an area by area approach to managing bycatch species is required in relation to the king scallop dredge fishery.

  20. Understanding King's Health Questionnaire (KHQ in assessment of female urinary incontinence

    Directory of Open Access Journals (Sweden)

    Shripad Hebbar

    2015-06-01

    Full Text Available Urinary incontinence has emerged as one of the leading medical problems for the geriatric population worldwide. Women are affected physically, mentally and socially and face embarrassment, depression and isolation. Increased life expectancy further adds to the prevalence of the condition and social, economic and health care burden. Although not sinister by itself, urinary incontinence has a profound impact on a woman's quality of life and warrants appropriate management. The efficacy of interventional procedures is measured by the caregiver mainly by improvement in urodynamic parameters. However, these gadgets do not assess the individuals satisfaction and feeling of wellbeing following the therapeutic intervention. Several generic QoL tools have been developed in an attempt to quantify these changes. But ironically, generic QoL questionnaires lack precision when applied to subjects with specific disease condition. In the context of female urinary problems, various QoL tools have been designed and investigated. King's Health Questionnaire (KHQ, which was formulated as early as 1997 by the group of researchers from King's College Hospital London still enjoys popularity till today, because of its strong psychometric properties, ease of administration and it adds objectivity to patient's subjective symptoms. However, the available information about KHQ is somewhat inadequate for the novice research scholar. The following brief essay aims at easy understanding of implementation, documentation, analysis and interpretation of King's Health Questionnaire in research settings. [Int J Res Med Sci 2015; 3(3.000: 531-538

  1. Robust Statistical Tests of Dragon-Kings beyond Power Law Distributions

    CERN Document Server

    Pisarenko, V F

    2011-01-01

    We ask the question whether it is possible to diagnose the existence of "Dragon-Kings" (DK), namely anomalous observations compared to a power law background distribution of event sizes. We present two new statistical tests, the U-test and the DK-test, aimed at identifying the existence of even a single anomalous event in the tail of the distribution of just a few tens of observations. The DK-test in particular is derived such that the p-value of its statistic is independent of the exponent characterizing the null hypothesis. We demonstrate how to apply these two tests on the distributions of cities and of agglomerations in a number of countries. We find the following evidence for Dragon-Kings: London in the distribution of city sizes of Great Britain; Moscow and St-Petersburg in the distribution of city sizes in the Russian Federation; and Paris in the distribution of agglomeration sizes in France. True negatives are also reported, for instance the absence of Dragon-Kings in the distribution of cities in Ger...

  2. BOREAS AFM-2 King Air 1994 Aircraft Flux and Moving Window Data

    Science.gov (United States)

    Kelly, Robert D.; Hall, Forrest G. (Editor); Newcomer, Jeffrey A. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    The BOREAS AFM-2 team collected pass-by-pass fluxes (and many other statistics) for a large number of level (constant altitude), straight-line passes used in a variety of flight patterns. The data were collected by the University of Wyoming King Air in 1994 BOREAS IFCs 1-3. Most of these data were collected at 60-70 m above ground level, but a significant number of passes were also flown at various levels in the planetary boundary layer, up to about the inversion height. This documentation concerns only the data from the straight and level passes that are presented as original (over the NSA and SSA) and moving window values (over the Transect). Another archive of King Air data is also available, containing data from all the soundings flown by the King Air 1994 IFCs 1-3. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884) or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  3. Aerosols in King George Island (Antarctic peninsula) using PIXE and alpha spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Dias da Cunha, K.; Medeiros, G., E-mail: kenya@ird.gov.b, E-mail: kenya@vdg.fis.puc-rio.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Leal, M.A.; Lima, C. [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil); Dalia, K.C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Centro de Ciencias da Saude; Barros Leite, C.V. [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ (Brazil)

    2009-07-01

    The aim of this study was to characterize the airborne particles and particles deposited in the recent snow samples collected at King George Island (Admiralty Bay) in order to evaluate the possible local sources of airborne particles and the aerosol transport from South America to Antarctic at sea level. Airborne particles samples were collected using a cascade impactor and cyclones at several sampling points at Admiralty Bay. Airborne particles were also collected during the ship travel from Rio de Janeiro to Antarctica. The recent snow samples and aerosols collected at several sampling points at Admiralty Bay were analyzed by PIXE for the determination of the elemental mass concentration. Snow samples were analyzed by alpha spectrometry to determine the 232Th, 228Th, 238U and 234U concentrations in snow. The Mass Median Aerodynamic Diameter of airborne particles was determined. The results suggest that there is a correlation between the aerosol samples and the particles deposited in the snow, but the elemental mass distributions are not equal. The snow elemental concentration can be used as an indicator of the elements present in the aerosols. The local aerosol sources (natural and anthropogenic) have been considered to characterize the aerosol transport to Antarctic, mainly King George Island. The main aerosol sources are the marine spray, weathering of local rocks and anthropogenic sources, as the diesel burning in the island. Besides the local aerosol sources the transport of airborne particles from south Atlantic to Antarctic is an important source of airborne particles at King George Island. (author)

  4. ‘Crack Nature’s Molds’: Reasoned Madness and Evolution in King Lear

    Directory of Open Access Journals (Sweden)

    Matthew Smith

    2015-06-01

    Full Text Available King Lear as a product of evolutionary progressions is logical because the play is framed around two ideas of society and generation in direct confrontation. The sociopolitical ramifications of King Lear are clarified when viewed as an evolutionary progression because societal causality is mirrored in nature. The connection between Lear’s madness and nature’s role in determining societal evolution is demonstrated in the evolutionary notion that “everybody is what he typically is because his progenitors were what they were . . . [i]n the molecular structure of the minute germ of him,” (Maudsley 4 and that and social events are connected with the mechanistic march of nature. When Lear bellows “Crack nature’s molds, all germens spill at once,” (3.2.8 he is requesting the impossible, that the laws of causation be terminated and evolution be put on hold.Keywords: Evolutionary Criticism, reason, philosophy, Shakespeare, King Lear, consilience, evolution, mechanism, madness, nature

  5. Ponded Impact Melt Dynamics and its Effects on Pond Surface Morphology - Insights from King Crater

    Science.gov (United States)

    Ashley, J. W.; DiCarlo, N.; Enns, A. C.; Hawke, B. R.; Hiesinger, H.; Robinson, M. S.; Sato, H.; Speyerer, E.; van der Bogert, C.; Wagner, R.; Young, K. E.; LROC Science Team

    2011-12-01

    King crater is a 77-km diameter impact feature located at 5.0°N and 120.5°E on the lunar farside. Previous work delimited King crater with an asymmetric distribution of ejecta that includes a large impact melt pond (~385 square kilometer surface area), located in nearby Al-Tusi crater. The pond provides an opportunity to study the behavior of a large impact melt deposit. The Lunar Reconnaissance Orbiter Camera (LROC) Wide Angle Camera (WAC) and Narrow Angle Cameras (NAC) [1] imaged King crater from a nominal 50 km altitude at pixel scales of 100 meters and up to 0.5 meters, respectively providing the means to create geologic maps for the region. Digital terrain/elevation models (DTMs) were derived [2] from both WAC and NAC images for the area, and supplemented the mapping effort. The high-resolution (50 cm/p) NAC images show fine details within the Al-Tusi melt pond that raise questions about melt pond dynamics and evolution. These include both positive- and negative-relief features, anomalous crater morphologies, and flow features that show variable degrees of melt viscosity. WAC DTM processing reveals a horizontal and relatively flat (at the 20 m contour interval) pond, demonstrating that an equipotential surface was achieved during initial melt accumulation. The NAC DTM shows kilometer-scale zones of topographic down-warping within the 20 m contour interval. The perimeters of these depressed areas show moderate to high spatial correlation with the occurrence of negative relief features (~10 to 100 m in length). Such sagging may have occurred as the result of contraction and/or compaction within the melt both during and following cooling, with the negative relief features resulting from consequent structural failure and separation of the thickening surface crust. The variability in the degree of contraction/compaction may be explained by the presence of underlying hummocky ejecta deposits (which probably also explains the positive relief features) emplaced by

  6. Were king Stefan the First-Crowned and his son Radoslav co-rulers?

    Directory of Open Access Journals (Sweden)

    Bubalo Đorđe

    2009-01-01

    Full Text Available The Serbian historiography considers the issue of the co-ruling of King Stefan the First-Crowned and his son Radoslav as the one finally resolved. The suggested solution on the co-rule of Stefan and Radoslav may be most succinctly expressed as following: as early as in the year of 1220, due to the frail health of Stefan the First-Crowned and Radoslav's marriage to Anne the Epirus princess, Radoslav was crowned to be the king and positioned to co-rule with his father after the Byzantine model of governing. Nevertheless this point of view has some loose ends. The notion of co-ruling and the very term of 'co-ruler' are quite freely used in the scholarly works. A general consensus on the precise meaning has not been reached yet. At the point where one author perceives a co-rule, the other categorically denies it. Basically the approach equalizing the heir to the throne and the co-ruler is wrong. Although the co-rulers in most cases were the throne heirs, they cannot be called the co-rulers because of the right to inherit the throne, but for the ruling attributes that formally established that right. The conviction of the co-rule of King Stefan and his son Radoslav is founded on the interpretation of the facts coming from the following sources: entitling charters for the monastery of Žiča, produced by Stefan and Radoslav around 1220; some segments from St. Sava's biographies by Domentian and Theodosius describing the circumstances of Stefan's death-bed leaving the throne to Radoslav; the three acts of the town of Kotor from 1221 and 1227 dated by the rule of king Radoslav, the portraits of Stefan and Radoslav next to the entrance to the Church of the Ascension in the monastery of Žiča and in the nartex of the Mileševa monastery church. In the first Žiča charter, Stefan calls Radoslav his heir, while in the second Žiča charter Stefan points out Radoslav as his first-born son blessed by him to be the king of the whole state. (jegože i

  7. Automated purification of Borrelia burgdorferi s.l. PCR products with KingFisher{sup TM} magnetic particle processor prior to genome sequencing

    Energy Technology Data Exchange (ETDEWEB)

    Maekinen, Johanna E-mail: johanna.makinen@utu.fi; Marttila, Harri; Viljanen, Matti K

    2001-07-01

    Borrelia burgdorferi sensu lato genospecies were differentiated by PCR-based sequencing of the borrelial flagellin gene. To evaluate the usefulness of KingFisher{sup TM} magnetic particle processor in PCR product purification, borrelia PCR products were purified with KingFisher{sup TM} magnetic particle processor prior to cycle sequencing and the quality of the sequence data received was analyzed. KingFisher was found to offer a rapid and reliable alternative for borrelial PCR product purification.

  8. Spatial patterns and movements of red king and Tanner crabs: Implications for the design of marine protected areas

    Science.gov (United States)

    Taggart, S.J.; Mondragon, J.; Andrews, A.G.; Nielsen, J.K.

    2008-01-01

    Most examples of positive population responses to marine protected areas (MPAs) have been documented for tropical reef species with very small home ranges; the utility of MPAs for commercially harvested temperate species that have large movement patterns remains poorly tested. We measured the distribution and abundance of red king Paralithodes camtschaticus and Tanner Chionoecetes bairdi crabs inside and outside of MPAs in Glacier Bay National Park, Alaska, USA. By tagging a sub-sample of crabs with sonic tags, we estimated the movement of adult crabs from one of the MPAs (Muir Inlet) into the central portion of Glacier Bay where fishing still occurs. Tanner crabs and red king crabs moved similar average distances per day, although Tanner crabs had a higher transfer out of the Muir Inlet MPA into the central bay. Tanner crab movements were characterized by large variation among individual crabs, both in distance and direction traveled, while red king crabs migrated seasonally between 2 specific areas. Although Tanner crabs exhibited relatively large movements, distribution and abundance data suggest that they may be restricted at large spatial scales by habitat barriers. MPAs that are effective at protecting king and especially Tanner crab brood stock from fishing mortality will likely need to be larger than is typical of MPAs worldwide. However, by incorporating information on the seasonal movements of red king crabs and the location of habitat barriers for Tanner crabs, MPAs could likely be designed that would effectively protect adults from fishing mortality. ?? Inter-Research 2008.

  9. Environmental conditions of interstadial (MIS 3 and features of the last glacial maximum on the King George island (West Antarctica

    Directory of Open Access Journals (Sweden)

    S. R. Verkulich

    2013-01-01

    Full Text Available The interstadial marine deposits stratum was described in the Fildes Peninsula (King George Island due to field and laboratory investigations during 2008–2011. The stratum fragments occur in the west and north-west parts of peninsula in following forms: sections of soft sediments, containing fossil shells, marine algae, bones of marine animals and rich marine diatom complexes in situ (11 sites; fragments of shells and bones on the surface (25 sites. According to the results of radiocarbon dating, these deposits were accumulated within the period 19–50 ky BP. Geographical and altitude settings of the sites, age characteristics, taxonomy of fossil flora and fauna, and good safety of the soft deposits stratum allow to make following conclusions: during interstadial, sea water covered significant part of King George Island up to the present altitude of 40 m a.s.l., and the King George Island glaciation had smaller size then; environmental conditions for the interstadial deposit stratum accumulation were at least not colder than today; probably, the King George island territory was covered entirely by ice masses of Last glacial maximum not earlier than 19 ky BP; during Last glacial maximum, King George Island was covered by thin, «cold», not mobile glaciers, which contribute to conservation of the soft marine interstadial deposits filled with fossil flora and fauna.

  10. Monarchical Activities of the Yoruba Kings of South Western Nigeria: A Cultural Heritage in Printmaking Visual Documentary.

    Directory of Open Access Journals (Sweden)

    Emmanuel Bankole Oladumiye

    2014-10-01

    Full Text Available Printmaking is a visual documentary media of art which was used as a medium of expression in analyzing myth and mythology monarchical activities of the Yorubas in South Western Nigeria in this study. The  monarchical activities of the Yoruba Kings, is  the cultural heritage and legacy that people do guide jealously and considered to be of high cultural value. The Yoruba Kings of South Western Nigeria are traditional entity which passed through the rites of installing kings for the throne fore fathers as a leader with symbol of authority between the people and the spirit world. The kings in Yoruba kingdom is so much respected that they are seen as divine and representative of God on earth and they are exalted into the position of deity because of his monarchical duties to his subjects at large. The funfairs that accompany the monarch roles  are worth documenting using printmaking as vehicle of visual and historical expression of myths and mythologies demonstrating African culture which stands out as sacred. The discourse also relies on oral testimonies written and archival documents. The materials used for the execution of the prints are rubber, wood, plate, offset printing inks and glass which records the events as an alternative to the use of photographic documentation. The research examine the philosophy behind the monarchical roles of the Yoruba Kings in print visuals based on the cultural heritage of the Yoruba people it employs an exploratory qualitative methods rely on literature review.

  11. Purification and antibacterial activities of an L-amino acid oxidase from king cobra (Ophiophagus hannah venom

    Directory of Open Access Journals (Sweden)

    CS Phua

    2012-01-01

    Full Text Available Some constituents of snake venom have been found to display a variety of biological activities. The antibacterial property of snake venom, in particular, has gathered increasing scientific interest due to antibiotic resistance. In the present study, king cobra venom was screened against three strains of Staphylococcus aureus [including methicillin-resistant Staphylococcus aureus (MRSA], three other species of gram-positive bacteria and six gram-negative bacteria. King cobra venom was active against all the 12 bacteria tested, and was most effective against Staphylococcus spp. (S. aureus and S. epidermidis. Subsequently, an antibacterial protein from king cobra venom was purified by gel filtration, anion exchange and heparin chromatography. Mass spectrometry analysis confirmed that the protein was king cobra L-amino acid oxidase (Oh-LAAO. SDS-PAGE showed that the protein has an estimated molecular weight of 68 kDa and 70 kDa under reducing and non-reducing conditions, respectively. The minimum inhibitory concentrations (MIC of Oh-LAAO for all the 12 bacteria were obtained using radial diffusion assay method. Oh-LAAO had the lowest MIC value of 7.5 µg/mL against S. aureus ATCC 25923 and ATCC 29213, MRSA ATCC 43300, and S. epidermidis ATCC 12228. Therefore, the LAAO enzyme from king cobra venom may be useful as an antimicrobial agent.

  12. Relationships between aerosol and snow chemistry at King Col, Mt. Logan Massif, Yukon, Canada

    Science.gov (United States)

    Yalcin, Kaplan; Wake, Cameron P.; Dibb, Jack E.; Whitlow, Sallie I.

    Simultaneous samples of aerosol ( n=48) and recent snow ( n=193) chemistry were collected at King Col (4135 m) in the St. Elias Mountains, Yukon, between 17 May and 11 June 2001. Major ion concentrations in aerosol samples were low with the total ionic burden averaging 5.52 neq m -3 at standard temperature and pressure (STP). Interspecies aerosol relationships indicate the presence of (NH 4) 2SO 4 aerosol at King Col. An aerosol Cl - deficiency relative to seawater suggests volatilization of HCl by reaction with unneutralized SO42- that is present in half of the samples. Backwards trajectories for select aerosol concentration peaks document the transport of Asian dust and anthropogenic emissions, the eruption plume from the 22 May eruption of Sheveluch, Kamchatka, and sea salt from the marine boundary layer over the Gulf of Alaska to King Col during the sampling period. Fresh snow chemistry generally mimics aerosol chemistry with similar relative abundances and interspecies relationships except for large enrichments in snow Cl - and NO3- relative to aerosol due to snow scavenging of gas-phase HCl and HNO 3. Although relatively strong correlations between aerosol and snow concentrations were observed for species associated with accumulation mode aerosols, e.g. NH4+ ( r=0.56) and SO42- ( r=0.43), only weak correlations were observed for dust and sea-salt species. These results are influenced by greater variability in concentrations between replicate snow samples for species associated with coarse mode dust and sea-salt particles and by snow scavenging of gas-phase HCl and HNO 3.

  13. Interns’ perceived abuse during their undergraduate training at King Abdul Aziz University

    Directory of Open Access Journals (Sweden)

    Iftikhar R

    2014-05-01

    Full Text Available Rahila Iftikhar,1 Razaz Tawfiq,2 Salem Barabie2 1Department of Family and Community Medicine, 2General Practice Department, King Abdul Aziz University, Jeddah, Saudi Arabia Background and objectives: Abuse occurs in all workplaces, including the medical field. The aim of this study was to determine the prevalence of perceived abuse among medical students, the types of abuse experienced during medical training, the source of abuse, and the perceived barriers to reporting abuse. Method: This cross-sectional survey was conducted between September 2013 and January 2014 among medical graduates of King Abdul Aziz University, Jeddah. The survey questionnaire was designed to gather information regarding the frequency with which participants perceived themselves to have experienced abuse, the type of abuse, the source of abuse, and the reasons for nonreporting of perceived abuse. Data were analyzed using the Statistical Package for the Social Sciences. Result: Of the 186 students enrolled in this study, 169 (90.9% reported perceiving some form of abuse during medical school training. Perceived abuse was most often verbal (86.6%, although academic abuse (73.1%, sex discrimination (38.7%, racial or ethnic discrimination (29.0%, physical abuse (18.8%, religious discrimination (15.1%, and sexual harassment (8.6% were also reported. Professors were most often cited as the sources of perceived abuse, followed by associate professors, demonstrators (or assistant teaching staff, and assistant professors. The Internal Medicine Department was the most frequently cited department where students perceived themselves to have experienced abuse. Only 14.8% of the students reported the abuse to a third party. Conclusion: The self-reported prevalence of medical student abuse at King Abdul Aziz University is high. A proper system for reporting abuse and for supporting victims of abuse should be set up, to promote a good learning environment. Keywords: maltreatment

  14. Eocene age of the Baranowski Glacier Group at Red Hill, King George Island, West Antarctica

    Directory of Open Access Journals (Sweden)

    Mozer Anna

    2015-12-01

    Full Text Available Radiometric and geochemical studies were carried out at Red Hill in the southern part of King George Island (South Shetland Islands, northern Antarctic Peninsula on the Bransfield Strait coast. The rock succession at Red Hill has been determined to represent the Baranowski Glacier Group that was previously assigned a Late Cretaceous age. Two formations were distinguished within this succession: the lower Llano Point Formation and the upper Zamek Formation. These formations have stratotypes defined further to the north on the western coast of Admiralty Bay. On Red Hill the Llano Point Formation consists of terrestrial lavas and pyroclastic breccia; the Zamek Formation consist predominantly of fine to coarse tuff, pyroclastic breccia, lavas, tuffaceous mud-, silt-, and sandstone, locally conglomeratic. The lower part of the Zamek Formation contains plant detritus (Nothofagus, dicotyledonous, thermophilous ferns and numerous coal seams (vitrinitic composition that confirm the abundance of vegetation on stratovolcanic slopes and surrounding lowlands at that time. Selected basic to intermediate igneous rocks from the succession have been analysed for the whole-rock K-Ar age determination. The obtained results indicate that the Red Hill succession was formed in two stages: (1 from about 51–50 Ma; and (2 46–42 Ma, i.e. during the Early to Middle Eocene. This, in combination with other data obtained from other Baranowski Glacier Group exposures on western coast of Admiralty Bay, confirms the recently defined position of the volcano-clastic succession in the stratigraphic scheme of King George Island. The new stratigraphic position and lithofacies development of the Red Hill succession strongly suggest its correlation with other Eocene formations containing fossil plants and coal seams that commonly occur on King George Island.

  15. Assessment of the health impacts of particulates from the redevelopment of Kings Cross.

    Science.gov (United States)

    Haynes, Ralph; Savage, Anna

    2007-07-01

    The Kings Cross/St. Pancras area has been a rail transport hub from Central London to the Midlands and North Eastern England since the middle of the nineteenth century and dust from the Kings Cross railway lands was even described by Charles Dickens. The Channel Tunnel high speed Rail Link (CTRL) is being constructed between 2001 and 2007 to connect continental Europe to Central London. The CTRL and associated development will help regenerate an area that is surrounded by deprived high density housing estates. London Borough of Camden has set up an extensive particulate monitoring programme to determine if there are any health impacts on local residents from emissions from the demolition and construction work. This article assesses the results from particulate measurements in 2003-2004 and compares this to baseline conditions before the redevelopment work began. The evidence suggests that although 2003 had higher than average pollution levels in the UK as a whole, even higher levels of particulates in the size range PM(10)-PM(2.5) (defined as PM(coarse)) were measured in Kings Cross. Due to the size of these particulates, they tend to be released from construction works rather than transport or secondary particulate sources. Concentrations in 2004 were lower than 2003, but this was primarily due to meteorological conditions. The paper also looks at the health of the local population and discusses whether these elevated levels are creating a problem and legally constitute a statutory nuisance. The Council continues to work with the contractors to try and ensure best practical means to minimise dust emissions and their effect on local residents.

  16. The origins of dragon-kings and their occurrence in society

    Science.gov (United States)

    Malkov, Artemy; Zinkina, Julia; Korotayev, Andrey

    2012-11-01

    A society is a medium with a complex structure of one-to-one relations between people. Those could be relations between friends, wife-husband relationships, relations between business partners, and so on. At a certain level of analysis, a society can be regarded as a gigantic maze constituted of one-to-one relationships between people. From a physical standpoint it can be considered as a highly porous medium. Such media are widely known for their outstanding properties and effects like self-organized criticality, percolation, power-law distribution of network cluster sizes, etc. In these media supercritical events, referred to as dragon-kings, may occur in two cases: when increasing stress is applied to a system (self-organized criticality scenario) or when increasing conductivity of a system is observed (percolation scenario). In social applications the first scenario is typical for negative effects: crises, wars, revolutions, financial breakdowns, state collapses, etc. The second scenario is more typical for positive effects like emergence of cities, growth of firms, population blow-ups, economic miracles, technology diffusion, social network formation, etc. If both conditions (increasing stress and increasing conductivity) are observed together, then absolutely miraculous dragon-king effects can occur that involve most human society. Historical examples of this effect are the emergence of the Mongol Empire, world religions, World War II, and the explosive proliferation of global internet services. This article describes these two scenarios in detail beginning with an overview of historical dragon-king events and phenomena starting from the early human history till the last decades and concluding with an analysis of their possible near future consequences on our global society. Thus we demonstrate that in social systems dragon-king is not a random outlier unexplainable by power-law statistics, but a natural effect. It is a very large cluster in a porous

  17. [Analysis on professor WANG Juyi's crevice theory from Tao Teh King].

    Science.gov (United States)

    Luo, Lu; Wang, Juyi

    2015-10-01

    The crevice theory proposed by professor WANG Juyi is analyzed in this article. In the crevice theory, it is believed that the meridians are located among "skin, pulse, flesh, tendon and bone", and the crevice is the path for the transportation of qi-blood and body fluid in the body, which is the essential condition for vital movement. This is in agreement with the idea of "action through inaction" from Tao Teh King. Based on crevice theory, the abnormalities of meridians can reflex the deficiency and excess of diseases, and regulating meridians is a significant way to treat diseases, and maintaining smooth meridian is important for healthcare.

  18. [Properties of chitinolytic enzymes from the hepatopancreas of the red king crab (Paralithodes camtschaticus)].

    Science.gov (United States)

    Novikov, V Iu; Mukhin, V A; Rysakova, K S

    2007-01-01

    Our study confirms the presence of chitinolytic, chitosanolytic, and deacetylase activities in the hepatopancreas of the red king crab, related to the specific diet of this species. The maximum rate of chitin/chitosan hydrolysis by an enzyme preparation from crab hepatopancreas occurs at 36.5-37.0 degrees C. Two pH optimums have been found for the enzymatic reaction under mildly alkaline and acidic conditions for both exo- and endochitinase activities. The enzyme preparation is most affine to partly deacetylated chitin with an acetylation degree within 40-50%.

  19. [Glycolytic activity of enzyme preparation from the red king crab (Paralithodes camtschaticus) hepatopancreas].

    Science.gov (United States)

    Rysakova, K S; Novikov, V Iu; Mukhin, V A; Serafimchik, E M

    2008-01-01

    Enzyme preparation exhibiting glycolytic activity yielding chitooligosaccharides along with N-acetyl-D-glucosamine was obtained from the red king crab (Paralithodes camtschaticus) hepatopancreas. The results of the analysis confirmed the presence of endo- and exochitinase activities in the preparation. HPLC showed that the hydrolysis products of chitin and chitosan did not contain D(+)-glucosamine, which is indicative of the absence of deacetylase and, apparently, exochitosanase activities. A comparison of the dependence of the enzyme preparation activity on temperature and pH of the incubation medium suggests that chitinase and protease activities are exhibited by different enzymes.

  20. THE AMERICAN PROPHET: THE INFLUENCE OF THE PROPHETIC ON MARTIN LUTHER KING JR

    OpenAIRE

    Ritchie, David T.

    2010-01-01

    The foundations of U.S. civil rights pioneer Martin Luther King Jr.’s thought are as variedand diverse as his vision for a new American society. As a Baptist minister his ideas were of courseshaped by the Christian ideals of that faith. He was also influenced, however, by religious and secularideals from other traditions. In this article I discuss the effect of the work of the Jewish theologian andsocial philosopher Martin Buber on King’s philosophy. In particular, I examine how Buber’s notio...

  1. An improved lower bound for (1,<=2)-identifying codes in the king grid

    OpenAIRE

    Foucaud, Florent; Laihonen, Tero; Parreau, Aline

    2011-01-01

    International audience; We call a subset $C$ of vertices of a graph $G$ a $(1,\\leq \\ell)$-identifying code if for all subsets $X$ of vertices with size at most $\\ell$, the sets $\\{c\\in C |\\exists u \\in X, d(u,c)\\leq 1\\}$ are distinct. The concept of identifying codes was introduced in 1998 by Karpovsky, Chakrabarty and Levitin. Identifying codes have been studied in various grids. In particular, it has been shown that there exists a $(1,\\leq 2)$-identifying code in the king grid with density ...

  2. Christopher R. Fee & David A. Leeming. Gods, Heroes, and Kings. The Battle for Mythic Britain

    Directory of Open Access Journals (Sweden)

    Sophie ALATORRE

    2006-06-01

    Full Text Available A reassessment of British mythology has long been overdue, and Gods, Heroes and Kings is to be regarded as a stimulating contribution which helps to situate Anglo-Saxon tales in the mainstream of Medieval literature. Myths, pagan and Judeo-Christian beliefs, classical narratives: such vast material forms the backcloth Christopher F. Fee and David A. Leeming have undertaken to explore, thanks to an erudite comparative approach. Obviously, their book first aims at giving readers a new image of ...

  3. Halley of 87 BC on the Coins of Armenian King Tigranes?

    CERN Document Server

    Gurzadyan, V G

    2004-01-01

    Coins of Armenian king Tigranes II the Great (95-55 BC), silver and copper-bronze tetradrachms and drachms, clearly reveal a star with a tail on the royal tiara which may be associated with the Halley's comet passage of 87 BC. If so, one has another case when astronomical events can be useful for historical chronological problems, this would be a far earlier record of Halley in Armenia than was previously known from chronicles and also one of the earliest known images of Halley's comet.

  4. Overvåking av Tokke-Vinje-vassdraget 2009-2011

    OpenAIRE

    Kaste, Ø.; Skancke, L.; Eriksen, T.; Kile, M.; Nylend, Anne

    2012-01-01

    Rapporten viser resultater fra vanndirektiv-relatert overvåking i 2009-2011 i Tokke-Vinje-vassdraget i Telemark. Omfanget av overvåkingen har variert mellom årene, men kvalitetselementene planteplankton, dyreplankton, påvekstalger og bunndyr, samt vannkjemiske og bakteriologiske støtteparametre har inngått i minst ett av årene. Målet med overvåkingen var å klassifisere tilstanden i utvalgte vannforekomster i forhold til vanndirektivets bestemmelser, samt identifisere lokaliteter hvor det er b...

  5. The Ancient Astronomy of Easter Island: Canopus and the Legendary King Hotu-Matua

    CERN Document Server

    Rjabchikov, Sergei

    2016-01-01

    Watchings of Canopus as a herald of the winter were important duties of ancient priests-astronomers on Easter Island. All the analysed data witness that this star was observed during the first and second voyages from Mangareva to the island. The names of king Hotu-Matua (Anua-Motua) and his father Tara tahi have been decoded. Several rongorongo records from the Esteban Atan manuscript have been deciphered advantageously. The new view at a painted barkcloth figurine connected with the bird-man cult has been offered. Some data about watchings of Aldebaran, the Pleiades, the sun, the moon, Venus and Mars have been collected as well.

  6. Preliminary evidence for 17 coastal terraces on Fildes Peninsula, King George Island, Antarctica

    Institute of Scientific and Technical Information of China (English)

    CHU Zhuding; YIN Xuebin; SUN Liguang; WANG Yuhong

    2015-01-01

    This study confirms the presence of 17 coastal terraces on Fildes Peninsula, Antarctica based on field observations and grain size analysis. The terraces formed by isostatic uplift during climate warming and glacier melting, and each level corresponds to a relatively stable period of climate. The grain size characteristics indicate an overlapping sedimentary origin for the sediments on the coastal terraces. The consistency of regional sea level rise, climate change, and glacial area suggest the presence of similar coastal terraces on King George Island since 18.0 ka.

  7. Morphological study on Littorina Flava (King & Broderip from Brazil (Caenogastropoda, Littorinidae

    Directory of Open Access Journals (Sweden)

    Luiz Ricardo L. Simone

    1998-12-01

    Full Text Available A detailed morphological study of the littorinid Littorina flava (King & Broderip, from Venezuelan and Brazilian coasts, is given and commented. a considerable degree of shell characters variation was found, mainly in color and sculpture. The pallial cavity presents normal fashion of mesogastropods, without any detectable morphological modification for the long air-exposure. The digestive system present odontophore muscles very similar to those of the cerithioideans and hydrobioideans; the radula, however, is enormously long; the stomach lacks differentiate style sac. The penis is characteristic in lacking annex glands. The pallial oviduct has no jelly gland, and has a well developed bursa copulatrix and vaginal tube.

  8. The Concept of Blindness in Sophocles' King Oedipus and Arthur Miller's Death of a Salesman

    OpenAIRE

    Md. Ziaul Haque; Fahmida Kabir Chowdhury

    2013-01-01

    In King Oedipus (429 B.C.E) by Sophocles and Death of a Salesman (1949 A.D) by Arthur Miller, the central characters Oedipus and Willy Loman take extreme pride in their professions; their pride blinds them from seeing the reality of their circumstances, and it eventually brings their ruin. At he same time, the other characters also display their figurative blindness in both the tragedies. However, it is demonstrated that the protagonists do not succeed in executing their responsibilities as l...

  9. Improved Monkey-King Genetic Algorithm for Solving Large Winner Determination in Combinatorial Auction

    Science.gov (United States)

    Li, Yuzhong

    Using GA solve the winner determination problem (WDP) with large bids and items, run under different distribution, because the search space is large, constraint complex and it may easy to produce infeasible solution, would affect the efficiency and quality of algorithm. This paper present improved MKGA, including three operator: preprocessing, insert bid and exchange recombination, and use Monkey-king elite preservation strategy. Experimental results show that improved MKGA is better than SGA in population size and computation. The problem that traditional branch and bound algorithm hard to solve, improved MKGA can solve and achieve better effect.

  10. DISCOVERY OF LATE CRETACEOUS PALYNOFLORA FROM FILDES PENINSULA, KING GEORGE ISLAND, ANTARCTICA AND ITS SIGNIFICANCE

    Institute of Scientific and Technical Information of China (English)

    1990-01-01

    This paper makes an analysis and study on altogether 8 palyniferous samples from the volcano-sedimentary rock series in the Half Three Point area of the Fildes Peninsula, King George Island, Antarctica, the rock series being grey tuffaceous siltstone in lithological characters, about 5m in thickness. Only after making a number of analyses, could we find the relatively abundant sporopollen fossils from 4 samples (Nos. GWP 4—7). But the fossils are poorly preserved, and most of them can hardly be identifi...

  11. A Catalog of previously unstudied clusters of IC, King and Dias

    CERN Document Server

    Tadross, A L

    2008-01-01

    The main astrophysical properties of 14 previously unstudied open star clusters are probed with JHK Near-IR (2MASS) photometry of Cutri et al. (2003) and proper motions (NOMAD) astrometry of Zacharias et al. (2004). The fundamental parameters have been derived for IC (1023, 1434, 2156); King (17, 18, 23, 25, 26); and Dias (2, 3, 4, 7, 8, 11), for which no prior parameters are available in the literature. The clusters' centers coordinates and angular diameters are re-determined, while ages, distances, and color excesses for these clusters are estimated here for the first time.

  12. Kandungan senyawa kimia pada bunga dan daun Chromolaena odorata L RM King dan H Robinson

    Directory of Open Access Journals (Sweden)

    Yuliasri Jamal

    1996-12-01

    Full Text Available An analysis on the chemical compounds of flowers and leaves of Chromolaena Odorata (L. R.M. King and H. Robinson from Timor island using GCMS, was conducted. Total number of the compound from flowers which can be detected were 18 considered of alkanes, oxygenated hydrocarbon, fatty acid, hydrazine, and alkaloid along with two unidentified compound (1,2. Twenty seven compound detected from leaves were identified as alkanes, fatty acid, alkaloid, hydrazine together with 12 unidentified compound (3-14. Compounds were identified using NIST Library data. Flower and leaves Chromolaena Odorata contained allelopathy compounds such as palmitic aid, linoleic acid, and 2.6-dimetoxy phenol.

  13. 基于King View组态软件的水电站实时监测系统设计%Design of a Real - time Detection System for Water Power Plant Based on King View Integrated Software

    Institute of Scientific and Technical Information of China (English)

    吴轶群; 向铁元

    2004-01-01

    King View组态软件为实时监测系统的设计提供了强有力的软件开发平台.它具有强大的数据采集与处理功能和动态显示的人机界面.基于King View组态软件的水电站监测系统的设计,理想地实现了对水电站相关设备的实时监测工作,并保障了设备系统的可靠、高效和安全运行.

  14. Isolation and identification of lactid acid bacteria originated from king grass (Pennisetum purpureophoides as candidate of probiotic for livestock

    Directory of Open Access Journals (Sweden)

    Santoso B

    2013-06-01

    Full Text Available A study was conducted to isolate and identify strain of lactic acid bacteria (LAB isolated from king grass, and to determine their potential as candidate of probiotic for livestock. The LAB was isolated by culturing king grass extract in De Man, Rogosa and Sharpe (MRS medium. The pure culture LAB was used to identify strain of bacteria using Analytical Profile Index (API 50 CH kit. The result showed that the strain bacteria was identified as Lactobacillus plantarum. L. plantarum was able to survive in extreme condition at pH 2 and 0.3% bile salt. L. plantarum also survived against pathogenic bacteria i.e. Staphylococcus aureus, Escherechia coli and Salmonella thypi. It is concluded that L. plantarum isolated from king grass could potentially to be used as probiotic for livestock.

  15. The Overview of Chemical Knowledge in Eighteenth Century Georgia According to the Chemistry Book by King Vakhtang VI

    Directory of Open Access Journals (Sweden)

    Ketevan Kupatadze

    2016-07-01

    Full Text Available The article deals with political and educational-cultural situation in Georgia during the reign of King Vakhtang VI (XVIII century. It describes the book on chemistry compiled and published by Vakhtang VI. The methods of chemical experiments highlighted in the book are compared to the methods of early alchemists, such as: Jābir ibn Hayyān, Muhammad ibn Zakariyā Rāzī, Liebau and others. The article summarizes the methods to which Vakhtang VI agreed and also indicates the techniques, slightly differently presented in his records. The paper also points out how the King could get information on chemistry. It gives an assumption that the scientific information most likely was brought by travelers who were close to the king or was accumulated from the early period and was also linked with journeys. DOI: http://dx.doi.org/10.17807/orbital.v8i3.839 

  16. Keystone and the Divine King:A Study on the Nyikang of the Shilluk and Divine Kingship

    Institute of Scientific and Technical Information of China (English)

    Wang Wenlan; Zhang Yahui

    2016-01-01

    In his famous book The Golden Bough,James Frazer mentioned one special custom found along the shores of Lake Nemi in Italy. The forest king who lived beside Lake Nemi, was not only once a prisoner, but also the murderer of his predecessor. Why did the King have to be killed? How could he be killed? This was the very starting point of James Frazer’s divine kingship study. This was in contrast to the common idea held in many cultures, that kings, or even gods, would die. However, in the most primitive societies, kings and gods also had a symbolic duty. People be-lieved that their king took the responsibility to maintain the order of society and the natural world. In that case, it was obvious that if the king became old and weak, the society and order would be in danger. The way used by primitive people to solve this problem was to kill the king when he became weak, and to rebuild this symbol of order through the accession of a new king. This worry about the loss of order and fertility, Frazer explained, was the reason why they choose to kill their king, who was also a god to them. To prove his theory, Fra-zer used many examples. Among them, the exam-ple of the Shilluk of Nilotic Sudan was the only real case of a people killing their king. All the kings were possessed by the spirit of Nyikang, who was not only a hero and king in their history, but also the god who created the universe of the Shilluk people. In Shilluk, it was not the king who ruled the country, but the spirit who possessed him. For that reason, once the king showed his weakness and age, he had to be killed or commit a suicide so as to keep Nyikang in a healthy body. This case was mentioned by James Frazer, re-examined by Evans-Pritchard, and discussed by Henri Frank-fort and David Graeber. The Shilluk people lived in Sudan, in the Ni-lotic area alongside the Nile River. Their kingdom consisted of y many hamlets and occupied by linea-ges. But all these hamlets and lineages shared the same king, who

  17. KING KONG

    DEFF Research Database (Denmark)

    Jochum, Elizabeth

    2013-01-01

    Director of puppetry Peter Wilson de- signed the choreography through a hybrid control system that combined automation, direct-control, and remote control of "voodoo" puppeteers hid- den offstage. The opportu- nity to watch the dynamic interaction between the puppet and the puppeteers highlighted...

  18. Development of a real-time PCR assay for detection of planktonic red king crab (Paralithodes camtschaticus (Tilesius 1815)) larvae

    Science.gov (United States)

    Jensen, Pamela C.; Purcell, Maureen K.; Morado, J. Frank; Eckert, Ginny L.

    2012-01-01

    The Alaskan red king crab (Paralithodes camtschaticus) fishery was once one of the most economically important single-species fisheries in the world, but is currently depressed. This fishery would benefit from improved stock assessment capabilities. Larval crab distribution is patchy temporally and spatially, requiring extensive sampling efforts to locate and track larval dispersal. Large-scale plankton surveys are generally cost prohibitive because of the effort required for collection and the time and taxonomic expertise required to sort samples to identify plankton individually via light microscopy. Here, we report the development of primers and a dual-labeled probe for use in a DNA-based real-time polymerase chain reaction assay targeting the red king crab, mitochondrial gene cytochrome oxidase I for the detection of red king crab larvae DNA in plankton samples. The assay allows identification of plankton samples containing crab larvae DNA and provides an estimate of DNA copy number present in a sample without sorting the plankton sample visually. The assay was tested on DNA extracted from whole red king crab larvae and plankton samples seeded with whole larvae, and it detected DNA copies equivalent to 1/10,000th of a larva and 1 crab larva/5mL sieved plankton, respectively. The real-time polymerase chain reaction assay can be used to screen plankton samples for larvae in a fraction of the time required for traditional microscopial methods, which offers advantages for stock assessment methodologies for red king crab as well as a rapid and reliable method to assess abundance of red king crab larvae as needed to improve the understanding of life history and population processes, including larval population dynamics.

  19. Arterial roads and area socioeconomic status are predictors of fast food restaurant density in King County, WA

    Directory of Open Access Journals (Sweden)

    Streichert Laura C

    2009-07-01

    Full Text Available Abstract Background Fast food restaurants reportedly target specific populations by locating in lower-income and in minority neighborhoods. Physical proximity to fast food restaurants has been associated with higher obesity rates. Objective To examine possible associations, at the census tract level, between area demographics, arterial road density, and fast food restaurant density in King County, WA, USA. Methods Data on median household incomes, property values, and race/ethnicity were obtained from King County and from US Census data. Fast food restaurant addresses were obtained from Public Health-Seattle & King County and were geocoded. Fast food density was expressed per tract unit area and per capita. Arterial road density was a measure of vehicular and pedestrian access. Multivariate logistic regression models containing both socioeconomic status and road density were used in data analyses. Results Over one half (53.1% of King County census tracts had at least one fast food restaurant. Mean network distance from dwelling units to a fast food restaurant countywide was 1.40 km, and 1.07 km for census tracts containing at least one fast food restaurant. Fast food restaurant density was significantly associated in regression models with low median household income (p Conclusion No significant association was observed between census tract minority status and fast food density in King County. Although restaurant density was linked to low household incomes, that effect was attenuated by arterial road density. Fast food restaurants in King County are more likely to be located in lower income neighborhoods and higher traffic areas.

  20. Inter-annual dynamics of the Barents Sea red king crab (Paralithodes camtschaticus) stock indices in relation to environmental factors

    Science.gov (United States)

    Dvoretsky, Alexander G.; Dvoretsky, Vladimir G.

    2016-12-01

    Knowledge of relationships between environmental variables and biological processes can greatly improve fisheries assessment and management in commercially important species. We analyzed the effects of environmental factors (climatic indices and water temperature) on the stock characteristics (total population number, number of pre-recruits and number of legal males) of the red king crab (Paralithodes camtschaticus), an introduced species in the Barents Sea. Stock trends in red king crab appear to be related to decadal climate shifts. Abundances were negatively related to the North Atlantic Oscillation index (NAO) in August and positively related to water temperature in late winter-early summer. Total and commercial stock abundance were negatively correlated with the lag-1 Arctic Oscillation index (AO) in August and the lag-2 winter NAO index. The total number of P. camtschaticus was most strongly associated with water temperature in spring and summer and NAO/AO indices in April and May. Lagged NAO indices in February and August (9 or 10 yr) had a positive relationship to the commercial stock of P. camtschaticus. These findings suggest that temperature conditions of current and previous year affect natural mortality of larvae and juvenile red king crabs. Warmer temperature conditions lead to increased biomass of red king crab food items. Negative correlations between climatic indices and the red king crab stocks may be associated with predator pressure on juvenile red king crabs or higher mortality because of predator or parasite pressure and diseases. The associations between stock indices and environmental variables could help better predict recruitment patterns of P. camtschaticus.

  1. The occurrence and development of peat mounds on King George Island (Maritime Antarctic

    Directory of Open Access Journals (Sweden)

    Jerzy Fabiszewski

    2014-02-01

    Full Text Available On King George Island, South Shetlands Islands, a type of peat formation has been discovered which has not previously been reported from the Antarctic. These formations are in shape of mounds up to 7x 15 m in area, with a peat layer of about I m thick. About twenty five cm below the surface there is a layer of permanently frozen peat. The mounds are covered by living mosses (Polytrichum alpinum and Drepanocladus uncinatus, Antarctic hair grass (Deschampsia antarctica and lichens. Erosion fissures occurring on the surface are evidence of contemporary drying and cessation of the mound's growth. The initial phase of the development of the mounds began with a community dominated by Calliergidium austro-stramineum and Deschampsia antarctica, and their further development has been due to peat accumulation formed almost entirely by Calliergidium. The location of the mounds is near a penguin rookery, which clearly conditioned the minerotrophic character of these formations, as compared with the "moss peat banks" formed by Chorisodontium aciphyllum and Polytrichum al-pestre. Moreover, the peat mounds differ from the latter in several ways, e.g. rate of growth and floristic composition. Radiocarbon dating of peat from the base of one mound gave an age of 4090±60 years B.P. This suggests that the age of the tundra on King George Island is about 5000-4000 years.

  2. Morbidity patterns among King Faisal university students, Al Hassa, Kingdom of Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Abdulrashid C Choudary

    2007-01-01

    Full Text Available Objectives : To explore the prevalent morbidity problems among students at King Faisal University. To identify the nature of referred cases and assess the efficiency of the referral system. Subjects and Methods : This was a retrospective, records-based descriptive study, involving the examination of the health records of students at King Faisal University, who attended the Medical Center for Primary Health Care services in a five-year period. A pre-tested compilation sheet was used for data collection. Results : Out of 2472 consultations, about 58 % of the diagnosed morbidity conditions were of infectious nature, mostly affecting the respiratory (62%, dental (14%, gastrointestinal (7%, and skin infections (5 %, with more prevalence among males. The non-infectious morbidity conditions were recorded more among females and included muscle and joints problems (16 %, allergic conditions (15 %, gastrointestinal (8 %, and trauma (5 %. Some of the encountered morbidity demonstrated seasonal variation. Case referrals were about 6 %, more in the non-infectious conditions, with a deficient feedback system. Conclusion : Quality improvement of the medical records and the establishment of a proper referral system are necessary. Health education on preventable morbid conditions should be organized and implemented.

  3. Genetic analysis of the presumptive blood from Louis XVI, King of France.

    Science.gov (United States)

    Lalueza-Fox, Carles; Gigli, Elena; Bini, Carla; Calafell, Francesc; Luiselli, Donata; Pelotti, Susi; Pettener, Davide

    2011-11-01

    A text on a pyrographically decorated gourd dated to 1793 explains that it contains a handkerchief dipped with the blood of Louis XVI, king of France, after his execution. Biochemical analyses confirmed that the material contained within the gourd was blood. The mitochondrial DNA (mtDNA) hypervariable region 1 (HVR1) and 2 (HVR2), the Y-chromosome STR profile, some autosomal STR markers and a SNP in HERC2 gene associated to blue eyes, were retrieved, and some results independently replicated in two different laboratories. The uncommon mtDNA sequence retrieved can be attributed to a N1b haplotype, while the novel Y-chromosome haplotype belongs to haplogroup G2a. The HERC2 gene showed that the subject analyzed was a heterozygote, which is compatible with a blue-eyed person, as king Louis XVI was. To confirm the identity of the subject, an analysis of the dried heart of his son, Louis XVII, could be undertaken.

  4. Genomic analysis of the blood attributed to Louis XVI (1754-1793), king of France.

    Science.gov (United States)

    Olalde, Iñigo; Sánchez-Quinto, Federico; Datta, Debayan; Marigorta, Urko M; Chiang, Charleston W K; Rodríguez, Juan Antonio; Fernández-Callejo, Marcos; González, Irene; Montfort, Magda; Matas-Lalueza, Laura; Civit, Sergi; Luiselli, Donata; Charlier, Philippe; Pettener, Davide; Ramírez, Oscar; Navarro, Arcadi; Himmelbauer, Heinz; Marquès-Bonet, Tomàs; Lalueza-Fox, Carles

    2014-04-24

    A pyrographically decorated gourd, dated to the French Revolution period, has been alleged to contain a handkerchief dipped into the blood of the French king Louis XVI (1754-1793) after his beheading but recent analyses of living males from two Bourbon branches cast doubts on its authenticity. We sequenced the complete genome of the DNA contained in the gourd at low coverage (~2.5×) with coding sequences enriched at a higher ~7.3× coverage. We found that the ancestry of the gourd's genome does not seem compatible with Louis XVI's known ancestry. From a functional perspective, we did not find an excess of alleles contributing to height despite being described as the tallest person in Court. In addition, the eye colour prediction supported brown eyes, while Louis XVI had blue eyes. This is the first draft genome generated from a person who lived in a recent historical period; however, our results suggest that this sample may not correspond to the alleged king.

  5. Pesticides detected in urban streams in King County, Washington, 1998-2003

    Science.gov (United States)

    Frans, Lonna M.

    2004-01-01

    The U.S. Geological Survey and the King County Department of Natural Resources collected water samples from 14 sites on urban streams in King County during storms and during base flow between 1998 and 2003. The samples were analyzed for the presence of 155 pesticides and pesticide transformation products. Thirty-nine of the compounds were detected at least once during the study: 20 herbicides, 9 insecticides, 2 fungicides, 6 pesticide transformation products, and 2 other types of compounds. The most widespread compound was 4-nitrophenol, which was detected at all 14 sampling sites. The most frequently detected compound was pentachlorophenol, a fungicide, which occurred in more than 80 percent of the samples. The most frequently detected herbicides were prometon, trichlopyr, 2,4-D, and MCPP, and the most frequently detected insecticides were diazinon and carbaryl. All of the most frequently detected herbicides and insecticides were sold for homeowner use over the timeframe of this study. More compounds were detected during storms than during base flow, and were detected more frequently and typically at high concentrations during storms. Seven compounds were detected only during storms. Most of the compounds that were detected during storms occurred more frequently during spring storms than during autumn storms.

  6. Characterizing the nutritional strategy of incubating king eiders Somateria spectabilis in northern Alaska

    Science.gov (United States)

    Bentzen, R.L.; Powell, A.N.; Williams, T.D.; Kitaysky, A.S.

    2008-01-01

    We measured plasma concentrations of variables associated with lipid metabolism (free fatty acids, glycerol, triglyceride, and ??- hydroxybutyrate), protein metabolism (uric acid), and baseline corticosterone to characterize the nutritional state of incubating king eiders Somateria spectabilis and relate this to incubation constancy at two sites, Kuparuk and Teshekpuk, in northern Alaska. King eiders at both sites appeared to employ a partial-income incubation strategy, relying on both endogenous and exogenous energy resources. Females maintained high invariant levels of free fatty acids, ??-hydroxybutyrate, and glycerol throughout incubation, indicating that fat reserves were a major energy source, and not completely depleted during incubation. Similarly, uric acid did not increase, suggesting effective protein sparing or protein ingestion and adequate lipid reserves throughout incubation. Baseline corticosterone and triglyceride levels increased during incubation, indicative of an increase in foraging during late stages of incubation. Incubating females at Kuparuk had higher triglyceride concentrations but also had higher ??-hydroxybutyrate concentrations than females at Teshekpuk. This dichotomy may reflect a short-term signal of feeding overlaying the longer-term signal of reliance on endogenous lipid reserves due to higher food intake yet higher metabolic costs at Kuparuk because of its colder environment. Incubation constancy was not correlated with plasma concentrations of lipid or protein metabolites. ?? 2008 The Authors.

  7. King Nikola and the territorial expansion of Montenegro, 1914-1920

    Directory of Open Access Journals (Sweden)

    Živojinović Dragoljub R.

    2014-01-01

    Full Text Available This article discusses the abortive efforts of King Nikola of Montenegro to achieve territorial expansion for his country during the First World War. Although he was a believer in the unification of Serbdom, he wanted to achieve it under his lead­ership rather than that of the Serbian Karadjordjević dynasty, and therefore had no intention of letting Montenegro be simply merged with Serbia and his family pushed into the background. Therefore, King Nikola campaigned not just for the preservation of Montenegro as an independent state, but also for its considerable territorial expansion, mostly at the expense of Austria-Hungary, and also at that of Serbia and Albania. He did not desist from his endeavours even at the time of his exile following the capitulation and occupation of Montenegro in 1916; on the contrary, it was then that his demands were most comprehensive. However, he could not resist the reality on the ground during and in the wake of the war, and all his efforts remained useless.

  8. Three new bricks in the wall: Berkeley 23, Berkeley 31, and King 8

    CERN Document Server

    Cignoni, Michele; Bragaglia, Angela; Tosi, Monica

    2011-01-01

    A comprehensive census of Galactic open cluster properties places unique constraints on the Galactic disc structure and evolution. In this framework we investigate the evolutionary status of three poorly-studied open clusters, Berkeley 31, Berkeley 23 and King 8, all located in the Galactic anti-centre direction. To this aim, we make use of deep LBT observations, reaching more than 6 mag below the main sequence Turn- Off. To determine the cluster parameters, namely age, metallicity, distance, reddening and binary fraction, we compare the observational colour-magnitude diagrams (CMDs) with a library of synthetic CMDs generated with different evolutionary sets (Padova, FRANEC and FST) and metallicities. We find that Berkeley 31 is relatively old, with an age between 2.3 and 2.9 Gyr, and rather high above the Galactic plane, at about 700 pc. Berkeley 23 and King 8 are younger, with best fitting ages in the range 1.1-1.3 Gyr and 0.8-1.3 Gyr, respectively. The position above the Galactic plane is about 500- 600 pc...

  9. Deepwater Chondrichthyan Bycatch of the Eastern King Prawn Fishery in the Southern Great Barrier Reef, Australia.

    Science.gov (United States)

    Rigby, Cassandra L; White, William T; Simpfendorfer, Colin A

    2016-01-01

    The deepwater chondrichthyan fauna of the Great Barrier Reef is poorly known and life history information is required to enable their effective management as they are inherently vulnerable to exploitation. The chondrichthyan bycatch from the deepwater eastern king prawn fishery at the Swain Reefs in the southern Great Barrier Reef was examined to determine the species present and provide information on their life histories. In all, 1533 individuals were collected from 11 deepwater chondrichthyan species, with the Argus skate Dipturus polyommata, piked spurdog Squalus megalops and pale spotted catshark Asymbolus pallidus the most commonly caught. All but one species is endemic to Australia with five species restricted to waters offshore from Queensland. The extent of life history information available for each species varied but the life history traits across all species were characteristic of deep water chondrichthyans with relatively large length at maturity, small litters and low ovarian fecundity; all indicative of low biological productivity. However, variability among these traits and spatial and bathymetric distributions of the species suggests differing degrees of resilience to fishing pressure. To ensure the sustainability of these bycatch species, monitoring of their catches in the deepwater eastern king prawn fishery is recommended.

  10. Hazard assessment of debris flows for Leung King Estateof Hong Kong by incorporating GIS with numericalsimulations

    Directory of Open Access Journals (Sweden)

    K. T. Chau

    2004-01-01

    Full Text Available As over seventy percent of the land of Hong Kong is mountainous, rainfall-induced debris flows are not uncommon in Hong Kong. The objective of this study is to incorporate numerical simulations of debris flows with GIS to identify potential debris flow hazard areas. To illustrate this approach, the proposed methodology is applied to Leung King Estate in Tuen Mun. A Digital Elevation Model (DEM of the terrain and the potential debris-flow sources were generated by using GIS to provide the required terrain and flow source data for the numerical simulations. A theoretical model by Takahashi et al. (1992 improved by incorporating a new erosion initiation criterion was used for simulating the runout distances of debris flows. The well-documented 1990 Tsing Shan debris flow, which occurred not too far from Leung King Estate, was used to calibrate most of the flow parameters needed for computer simulations. Based on the simulation results, a potential hazard zone was identified and presented by using GIS. Our proposed hazard map was thus determined by flow dynamics and a deposition mechanism through computer simulations without using any so- called expert opinions, which are bounded to be subjective and biased.

  11. Characterising terrestrial influences on Antarctic air masses using radon-222 measurements at King George Island

    Directory of Open Access Journals (Sweden)

    S. D. Chambers

    2014-05-01

    Full Text Available We report on one year of high precision direct hourly radon observations at King Sejong Station (King George Island beginning in February 2013. Findings are compared with historic and ongoing radon measurements from other Antarctic sites. Monthly median concentrations reduced from 72 mBq m−3 in late summer to 44 mBq m−3 in late-winter and early-spring. Monthly 10th percentiles, ranging from 29 to 49 mBq m−3, were typical of oceanic baseline values. Diurnal cycles were rarely evident and local influences were minor, consistent with regional radon flux estimates one tenth of the global average for ice-free land. The predominant fetch region for terrestrially influenced air masses was South America (47–53° S, with minor influences also attributed to aged Australian air masses and local sources. Plume dilution factors of 2.8–4.0 were estimated for the most terrestrially influenced (South American air masses, and a seasonal cycle in terrestrial influence on tropospheric air descending at the pole was identified and characterised.

  12. The leadership principles of Dr. Martin Luther King, Jr. and their relevance to surgery.

    Science.gov (United States)

    Brunicardi, F Charles; Cotton, Ronald T; Cole, George W; Martinez, George

    2007-01-01

    In order to face the challenges in healthcare this century, it is essential that surgeons understand modern leadership principles. One of the greatest leaders in history was Dr. Martin Luther King, Jr., who provides a shining example of level-5 leadership for us to study. The study of leadership principles of great leaders can provide us with practical methods of conflict resolution as well as inspiration to keep us engaged and focused. As leaders of the medical community, we face numerous challenges, including discovering and implementing new treatments for disease, providing care for the indigent, overcoming educational challenges such as incorporating the ACGME Core Competencies into our surgical training and promoting diversity in education. Achieving these goals is often hindered by the environment in which we labor-nearly 50 million are uninsured, the rising cost of medical care is currently at 16% of the GNP, and reimbursement rates are falling-which makes the practice of surgery a significant challenge. Effective leadership will be paramount in achieving these goals. In this editorial, which summarizes a presentation given to the Surgical Section of the annual National Medical Association meeting, five important leadership principles that are important for surgeons have been selected and related to the outstanding leadership of Dr. Martin Luther King, Jr.

  13. Book review: Martin’s dream: my journey and the legacy of Martin Luther King Jr.\\ud

    OpenAIRE

    McCormick, Roger

    2013-01-01

    "Martin’s Dream: My Journey and the Legacy of Martin Luther King Jr." Clayborne Carson. Palgrave Macmillan. January 2013. --- \\ud Written with the unique perspective of someone who has, for three decades, been involved with Martin Luther King Jr.’s legacy, Clayborne Carson gives readers an insider’s account of what transpired after the Dream speech, and beyond. A rich and engrossing memoir of black empowerment at a unique moment in time, this is an undoubtedly special contribution to King’s m...

  14. Silage Quality of King Grass (Pennisetum purpureophoides Treated with Epiphytic Lactic Acid Bacteria and Tannin of Acacia

    Directory of Open Access Journals (Sweden)

    B. Santoso

    2011-08-01

    Full Text Available The aim of this study was to evaluate the silage quality of king grass (Pennisetum purpureophoides treated with addition of epiphytic lactic acid bacteria (LAB prepared from fermented grass extract (FGE or combined with tannin of acacia. Experiment was arranged to a completely randomized design with six treatments and three replications. Treatments were (A king grass without additive as a control; (B king grass + 3% (v/w of FGE; (C king grass + 3% (v/w of FGE + 10 ml of acacia extract (50 g/100 ml; (D king grass + 3% of FGE (v/w + 10 ml of acacia extract (50 g/75 ml; (E king grass + 3% of FGE (v/w + 10 ml of acacia extract (50 g/50 ml, and (F king grass + 3% of FGE (v/w + 10 ml of acacia extract (50 g/25 ml. About 250 g of silage materials were ensiled in 400 ml bottle silos at room temperatures (approximately 28 °C for 30 days. Variables measured were characteristics of FGE, fermentation characteristics and chemical composition of silage. Data were analyzed by analysis of variance and the significance differences among means were tested by the Duncan’s multiple range test. Results showed that the number of lactic acid bacteria in FGE increased from 0.8 × 107 cfu/ml to 2.9 × 107 cfu/ml after 2 days anaerobic incubation. Concentration of lactic acid in silages with addition of FGE or combined with tannin of acacia (B, C, D, E, and F were higher (P<0.01 than that of silage A (control. Silages with addition of FGE combined with tannin of acacia (C, D, E, and F had lower pH value than that of silages A and B. Concentrations of NH3-N decreased with increasing concentration of tannin. Butyric acid concentration decreased in silages B, C, D, E, and F as compared to that in silage A. Addition of FGE combined with tannin prepared from acacia leaf improved fermentation quality of king grass silage.

  15. Geologic map of southwestern Sequoia National Park and vicinity, Tulare County, California, including the Mineral King metamorphic pendant

    Science.gov (United States)

    Sisson, T. W.; Moore, J. G.

    2012-12-01

    From the late 1940s to the early 1990s, scientists of the U.S. Geological Survey (USGS) mapped the geology of most of Sequoia and Kings Canyon National Parks, California, and published the results as a series of 15-minute (1:62,500 scale) Geologic Quadrangles. The southwest corner of Sequoia National Park, encompassing the Mineral King and eastern edge of the Kaweah 15-minute topographic quadrangles, however, remained unfinished. At the request of the National Park Service's Geologic Resources Division (NPS-GRD), the USGS has mapped the geology of that area using 7.5-minute (1:24,000 scale) topographic bases and high-resolution ortho-imagery. With partial support from NPS-GRD, the major plutons in the map area were dated by the U-Pb zircon method with the Stanford-USGS SHRIMP-RG ion microprobe. Highlights include: (1) Identification of the Early Cretaceous volcano-plutonic suite of Mineral King (informally named), consisting of three deformed granodiorite plutons and the major metarhyolite tuffs of the Mineral King metamorphic pendant. Members of the suite erupted or intruded at 130-140 Ma (pluton ages: this study; rhyolite ages: lower-intercept concordia from zircon results of Busby-Spera, 1983, Princeton Ph.D. thesis, and from Klemetti et al., 2011, AGU abstract) during the pause of igneous activity between emplacement of the Jurassic and Cretaceous Sierran batholiths. (2) Some of the deformation of the Mineral King metamorphic pendant is demonstrably Cretaceous, with evidence including map-scale folding of Early Cretaceous metarhyolite tuff, and an isoclinally folded aplite dike dated at 98 Ma, concurrent with the large 98-Ma granodiorite of Castle Creek that intruded the Mineral King pendant on the west. (3) A 21-km-long magmatic synform within the 99-100 Ma granite of Coyote Pass that is defined both by inward-dipping mafic inclusions (enclaves) and by sporadic, cm-thick, sharply defined mineral layering. The west margin of the granite of Coyote Pass overlies

  16. An "Aufbau" Approach to Understanding How the King-Altman Method of Deriving Rate Equations for Enzyme-Catalyzed Reactions Works

    Science.gov (United States)

    Sims, Paul A.

    2009-01-01

    The King-Altman method of deriving rate equations for enzymatic reactions is applied to the derivation of the Michaelis-Menten equation, along with an explanation for how (or why) the King-Altman method works in this case. The slightly more complicated cases of competitive inhibition and a two-substrate enzyme-catalyzed reaction are then treated…

  17. An "Aufbau" Approach to Understanding How the King-Altman Method of Deriving Rate Equations for Enzyme-Catalyzed Reactions Works

    Science.gov (United States)

    Sims, Paul A.

    2009-01-01

    The King-Altman method of deriving rate equations for enzymatic reactions is applied to the derivation of the Michaelis-Menten equation, along with an explanation for how (or why) the King-Altman method works in this case. The slightly more complicated cases of competitive inhibition and a two-substrate enzyme-catalyzed reaction are then treated…

  18. The Mutable Prophet: Dr. Martin Luther King, Jr., and the Echo Chamber Campaign of "U. S. News & World Report," 1964-1968.

    Science.gov (United States)

    Lentz, Richard

    Between 1964 and 1968, "U. S. News and World Report" engaged in symbolic discourse with its readership through its coverage of Dr. Martin Luther King, Jr. "U. S. News" faced a dilemma in the mingling of King's force as a symbol with the power exerted by the egalitarian principles that Gunnar Myrdal identified as components of…

  19. A natural resource condition assessment for Sequoia and Kings Canyon National Parks: Appendix 22: climatic change

    Science.gov (United States)

    Das, Adrian J.; Stephenson, Nathan L.

    2013-01-01

    Climate is a master controller of the structure, composition, and function of biotic communities, affecting them both directly, through physiological effects, and indirectly, by mediating biotic interactions and by influencing disturbance regimes. Sequoia and Kings Canyon National Park’s (SEKI’s) dramatic elevational changes in biotic communities -- from warm mediterranean to cold alpine -- are but one manifestation of climate’s overarching importance in shaping SEKI’s landscape. Yet humans are now altering the global climate, with measurable effects on ecosystems (IPCC 2007). Over the last few decades across the western United States, human-induced climatic changes have likely contributed to observed declines in fraction of precipitation falling as snow and snowpack water content (Mote et al. 2005, Knowles et al. 2006), advance in spring snowmelt (Stewart et al. 2005, Barnett et al. 2008), and consequent increase in area burned in wildfires (Westerling et al. 2006). In the Sierra Nevada, warming temperatures have likely contributed to observed glacial recession (Basagic 2008), uphill migration of small mammals (Moritz et al. 2008), and increasing tree mortality rates (van Mantgem and Stephenson 2007, van Mantgem et al. 2009). More substantial changes can be expected for the future (e.g., IPCC 2007). Given the central importance of climate and climatic changes, we sought to describe long-term trends in temperature and precipitation at SEKI. Time and budget constraints limited us to analyses of mean annual temperature and mean annual precipitation, using readily-available data. If funds become available in the future, further analyses will be needed to analyze trends by season, trends in daily minimum and maximum temperatures, and so on. We chose to analyze data from individual weather stations rather than use interpolated climatic data from sources such as PRISM (http://www.prism.oregonstate.edu/). In topographically complex mountainous regions with few

  20. Effect of experience with pine (Pituophis melanoleucus) and king (Lampropeltis getulus) snake odors on Y-maze behavior of pine snake hatchlings.

    Science.gov (United States)

    Burger, J; Boarman, W; Kurzava, L; Gochfeld, M

    1991-01-01

    The abilities of hatchling pine snakes (Pituophis melanoleucus) and king snakes (Lampropeltis getulus) to discriminate the chemical trails of pine and king snakes was investigated inY-maze experiments. Pine snakes were housed for 17 days either with shavings impregnated with pine snake odor, king snake odor, or no odor to test for the effect of experience on choice. Both pine and king snake hatchlings entered the arm with the pine snake odor and did not enter the arm with the king snake odor. The data support the hypothesis that hatchlings of both species can distinguish conspecific odors from other odors and that our manipulation of previous experience was without effect for pine snake hatchlings.

  1. Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah).

    Science.gov (United States)

    Tan, Choo Hock; Tan, Kae Yi; Fung, Shin Yee; Tan, Nget Hong

    2015-09-10

    The king cobra (Ophiophagus hannah) is widely distributed throughout many parts of Asia. This study aims to investigate the complexity of Malaysian Ophiophagus hannah (MOh) venom for a better understanding of king cobra venom variation and its envenoming pathophysiology. The venom gland transcriptome was investigated using the Illumina HiSeq™ platform, while the venom proteome was profiled by 1D-SDS-PAGE-nano-ESI-LCMS/MS. Transcriptomic results reveal high redundancy of toxin transcripts (3357.36 FPKM/transcript) despite small cluster numbers, implying gene duplication and diversification within restricted protein families. Among the 23 toxin families identified, three-finger toxins (3FTxs) and snake-venom metalloproteases (SVMPs) have the most diverse isoforms. These 2 toxin families are also the most abundantly transcribed, followed in descending order by phospholipases A2 (PLA2s), cysteine-rich secretory proteins (CRISPs), Kunitz-type inhibitors (KUNs), and L-amino acid oxidases (LAAOs). Seventeen toxin families exhibited low mRNA expression, including hyaluronidase, DPP-IV and 5'-nucleotidase that were not previously reported in the venom-gland transcriptome of a Balinese O. hannah. On the other hand, the MOh proteome includes 3FTxs, the most abundantly expressed proteins in the venom (43 % toxin sbundance). Within this toxin family, there are 6 long-chain, 5 short-chain and 2 non-conventional 3FTx. Neurotoxins comprise the major 3FTxs in the MOh venom, consistent with rapid neuromuscular paralysis reported in systemic envenoming. The presence of toxic enzymes such as LAAOs, SVMPs and PLA2 would explain tissue inflammation and necrotising destruction in local envenoming. Dissimilarities in the subtypes and sequences between the neurotoxins of MOh and Naja kaouthia (monocled cobra) are in agreement with the poor cross-neutralization activity of N. kaouthia antivenom used against MOh venom. Besides, the presence of cobra venom factor, nerve growth factors

  2. On the Differences between Chinese and Western Culture--From Fighting Against the Flood of King Yu to Noah's Ark

    Institute of Scientific and Technical Information of China (English)

    张长江

    2015-01-01

    With the increasing cross-culture communication, more and more linguists come to realize that the cultural gap is a large obstacle in cultural transition and social intercourse.This paper discusses the differences between Chinese and Western culture from King Yu combating the flood to Noah's Ark to help Chinese communicate with westerners and develop Cross-Cultural Communication smoothly.

  3. Pragmatic Analyses of Martin Luther King (Jr)'s Speech: "I Have a Dream"--An Introspective Prognosis

    Science.gov (United States)

    Josiah, Ubong E.; Oghenerho, Gift

    2015-01-01

    This paper investigates the speech of Martin Luther King (Jr.) titled: "I Have a Dream", presented in 1963 at the Lincoln Memorial. This speech is selected for use because it involves a speaker and an audience who belong to a particular speech community. The speech is about the failed promises by the Americans whose dream advocate…

  4. "Some People Even Died": Martin Luther King, Jr, the Civil Rights Movement and the Politics of Remembrance in Elementary Classrooms

    Science.gov (United States)

    Wills, John S.

    2005-01-01

    This article examines the interpretive practices and cultural texts that shape what teachers and students remember and forget during the annual observance of the King holiday in two second-grade classrooms. Drawing on data from an ethnographic case study of the curriculum in use and theory and research on collective memory, the author analyzes the…

  5. Elujõuline Eesti etnoloogia / Terje Anepaio, Aivar Jürgenson, Timothy King, Art Leete ; interv. Maarja Kaaristo

    Index Scriptorium Estoniae

    2006-01-01

    Etnoloogia hetkeseisu ja tuleviku üle arutlevad Eesti Rahva Muuseumi teadusdirektor Terje Anepaio, Ajaloo Instituudi etnoloogia osakonna juhataja vanemteadur Aivar Jürgenson, Tallinna Ülikooli antropoloogia õppekava juht Timothy King ja Tartu Ülikooli etnoloogia õppetooli professor Art Leete

  6. Martin Luther King Jr.'s "I Have a Dream" in Context: Ceremonial Protest and African American Jeremiad.

    Science.gov (United States)

    Vander Lei, Elizabeth; Miller, Keith D.

    1999-01-01

    Discusses how "I Have a Dream" is the product of African-American rhetorical traditions of ceremonial protest and jeremiad speech-making, rituals that had crystallized long before King was born. Describes the peaceful essences of the March on Washington and how it was a "Ceremonial Protest." Considers the historical use of…

  7. Supernatural threats to kings: exploration of a motif in the Ulster Cycle and in other medieval Irish tales

    NARCIS (Netherlands)

    Borsje, J.; Ó hUiginn, R.; Ó Catháin, B.

    2009-01-01

    The subject of this contribution is the belief in a sacral bond between the land and the ruler. This belief is connected with the concept known as ‘sacral kingship’, which is found in many cultures. In the Tenach or Old Testament, for instance, the king is supposed to be chosen by God and anointed b

  8. Perceptions and Performance of King Saud University Students' about Concept and Finding Limit of Functions Graphical and Symbolic

    Science.gov (United States)

    El-khateeb, Mahmoud M. A.

    2015-01-01

    The purpose of this study was to investigate the misperceptions and performance of king Saud University students' about concept and finding the limit of same partial functions given in the form of both graphical and symbolic. In the collection of the data, the researcher employed the open-ended question test consisted of four items. Firstly,…

  9. The Effect of King Grass Silage on the Nitrogen Balance and Hematological Profile of Ettawa Grade Male Goat

    Directory of Open Access Journals (Sweden)

    S. Sunarso

    2012-04-01

    Full Text Available The aims of this research was to study the nutritional value of ensiled King Grass (Pennisetum purpuphoides to be applied for goat. Twelve Ettawa grade male (PE, + 10 months old, and with average body weight of 19.45 + 3.03 kg were used to determine the voluntary intake, balance nitrogen and their hematological profile. All of the animals were randomly allotted at individual pens. Data were analyzed statistically using analysis of variance, based on completely randomized design arrangement with four treatments (level of King Grass silage and three replicates. Treatment means were compared using Duncan multiple range test. The result showed that increasing level of King Grass silage within ration significantly increased the average dry matter (DM intake per metabolic body weight. In fact, the daily DM intake, nitrogen balance, blood hemoglobin and blood hematocrit of the experimental animals were not affected by level of King Grass silage feed. Experiment had no bad effect on healthy condition of the treated goat, so it implies that conserving grass as silage and then feeding grass silage to goat might be implemented by farmers to secure the continuous supply of green forage to keep the goat production sustainability all year round. [Keywords: silage, nitrogen balance, haemoglobin, haematocryt, goat

  10. An Author as a Counter-Storyteller: Applying Critical Race Theory to a "Coretta Scott King Award Book"

    Science.gov (United States)

    Brooks, Wanda

    2009-01-01

    This article analyzes the 2002 Coretta Scott King Award book by Mildred Taylor entitled "The Land". The novel and its author are situated within a tradition of historical fiction written by and about African Americans. I then offer an analysis that utilizes Critical Race Theory as an interpretive tool for examining the ways Taylor embeds meanings…

  11. Supernatural threats to kings: exploration of a motif in the Ulster Cycle and in other medieval Irish tales

    NARCIS (Netherlands)

    Borsje, J.; Ó hUiginn, R.; Ó Catháin, B.

    2009-01-01

    The subject of this contribution is the belief in a sacral bond between the land and the ruler. This belief is connected with the concept known as ‘sacral kingship’, which is found in many cultures. In the Tenach or Old Testament, for instance, the king is supposed to be chosen by God and anointed

  12. To Be, or Not to Be:Comparison of Oedipus the King and Hamlet the Prince of Denmark as Tragedies

    Institute of Scientific and Technical Information of China (English)

    WANG Yi-lin

    2016-01-01

    Oedipus the King and Hamlet the Prince of Denmark are two classic tragedies. They successfully achieved the dramat-ic and tragic effects, and fulfilled three essential elements expounded by Aristotle, that is, complicated plot, emotion of pity and fear, and action of reversal effect. However, the two dramas are quite different in the three elements.

  13. The Political, Socio-Economic and Sociocultural Impacts of the King Abdullah Scholarship Program (KASP) on Saudi Arabia

    Science.gov (United States)

    Hilal, Kholoud T.; Scott, Safiyyah; Maadad, Nina

    2015-01-01

    Since 2006, Saudi Arabian politicians, economists and sociologists have had to consider the implications of their country's King Abdullah Scholarship Program (KASP). Because Saudi Arabia has certain religious traditions and economic practices that are sensitive, international scholars are examining from different perspectives the outcomes and…

  14. Seasonal variation of algal growth conditions in sheltered Antarctic bays: the example of Potter Cove (King George Island, South Shetlands)

    NARCIS (Netherlands)

    Klöser, H.; Ferreyra, G.; Schloss, I.; Mercuri, G.; Laturnus, F.; Curtosi, A.

    1993-01-01

    Wind, air temperature, surface irradiance, light penetration into the water, salinity and water temperature have been recorded from mid November to mid February in Potter Cove, King George Island. Results are compared with published data on requirements for growth of Antarctic microalgae. The invest

  15. Seasonal variation of algal growth conditions in sheltered Antarctic bays: the example of Potter Cove (King George Island, South Shetlands)

    NARCIS (Netherlands)

    Klöser, H.; Ferreyra, G.; Schloss, I.; Mercuri, G.; Laturnus, F.; Curtosi, A.

    1993-01-01

    Wind, air temperature, surface irradiance, light penetration into the water, salinity and water temperature have been recorded from mid November to mid February in Potter Cove, King George Island. Results are compared with published data on requirements for growth of Antarctic microalgae. The

  16. The Limits of Master Narratives in History Textbooks: An Analysis of Representations of Martin Luther King, Jr.

    Science.gov (United States)

    Alridge, Derrick P.

    2006-01-01

    In this study, I argue that American history textbooks present discrete, heroic, one-dimensional, and neatly packaged master narratives that deny students a complex, realistic, and rich understanding of people and events in American history. In making this argument, I examine the master narratives of Martin Luther King, Jr., in high school history…

  17. Elujõuline Eesti etnoloogia / Terje Anepaio, Aivar Jürgenson, Timothy King, Art Leete ; interv. Maarja Kaaristo

    Index Scriptorium Estoniae

    2006-01-01

    Etnoloogia hetkeseisu ja tuleviku üle arutlevad Eesti Rahva Muuseumi teadusdirektor Terje Anepaio, Ajaloo Instituudi etnoloogia osakonna juhataja vanemteadur Aivar Jürgenson, Tallinna Ülikooli antropoloogia õppekava juht Timothy King ja Tartu Ülikooli etnoloogia õppetooli professor Art Leete

  18. Pretext, Context, Subtext: Textual Power in the Writing of Langston Hughes, Richard Wright, and Martin Luther King, Jr.

    Science.gov (United States)

    Bogumil, Mary L.; Molino, Michael R.

    1990-01-01

    Studies verbal pretexts, social subtexts, and interpretive contexts of works by Langston Hughes, Richard Wright, and Martin Luther King, Jr. Notes that cultural repression is propagated (and dispelled) in part through the power of language. Notes that these texts are relevant for teaching textual power in hopes of affecting social change. (RS)

  19. 76 FR 73761 - Notice to Rescind the Notice of Intent to Develop the Environmental Impact Statement: Kings...

    Science.gov (United States)

    2011-11-29

    ... the east to Atlantic Avenue on the west. The purpose of the original Project was to address various... TRANSPORTATION Federal Highway Administration Notice to Rescind the Notice of Intent to Develop the Environmental Impact Statement: Kings County, NY AGENCY: Federal Highway Administration (FHWA), United States...

  20. A CLINICAL ASSESSMENT OF MACINTOSH BLADE, MILLER BLADE AND KING VISIONTM VIDEOLARYNGOSCOPE FOR LARYNGEAL EXPOSURE AND DIFFICULTY IN ENDOTRACHEAL INTUBATION

    Directory of Open Access Journals (Sweden)

    Apoorva Mahendera

    2016-03-01

    Full Text Available CONTEXT Previous studies suggest glottic view is better achieved with straight blades while tracheal intubation is easier with curved blades and videolaryngoscope is better than conventional laryngoscope. AIMS Comparison of conventional laryngoscope (Macintosh blade and Miller blade with channelled videolaryngoscope (King Vision TM with respect to laryngeal visualisation and difficulty in endotracheal intubation. SETTINGS AND DESIGN This prospective randomised comparative study was conducted at a tertiary care hospital (in ASA I and ASA II patients after approval from the Institutional Ethics Committee. METHODS We compared Macintosh, Miller, and the King VisionTM videolaryngoscope for glottic visualisation and ease of tracheal intubation. Patients undergoing elective surgeries under general anaesthesia requiring endotracheal intubation were randomly divided into three groups (N=180. After induction of anaesthesia, laryngoscopy was performed and trachea intubated. We recorded visualisation of glottis (Cormack-Lehane grade-CL, ease of intubation, number of attempts, need to change blade, and need for external laryngeal manipulation. STATISTICAL ANALYSIS Demographic data, Mandibular length, Mallampati classification were compared using ANOVA, Chi-square test, Kruskal-Wallis Test, where P value <0.005 is statically significant. RESULTS CL grade 1 was most often observed in King Vision -TM VL group (90% which is followed by Miller (28.33%, and Macintosh group (15%. We found intubation was to be easier (grade 1 with King Vision -TM VL group (73.33%, followed by Macintosh (38.33%, and Miller group (1.67%. External manipulation (BURP was needed more frequently in patients in Miller group (71.67%, followed by Macintosh (28.33% and in King Vision -TM VL group (6.67%. All (100% patients were intubated in the 1 st attempt with King Vision -TM VL group, followed by Macintosh group (90% and Miller group (58.33%. CONCLUSIONS In patients with normal airway

  1. CONTEXTUAL MEANING STUDY OF TRANSLATION OF CHILDRENS STORY THE LION KING FROM ENGLISH INTO INDONESIAN

    Directory of Open Access Journals (Sweden)

    Djuria Suprato

    2010-04-01

    Full Text Available Article aimed to present study on the translation of words, phrases, expressions and sentences in a children's story.The story of "The Lion King" was used as case and content analysis was applied as a reference for the study. The focus of this analysis was aimed to observe the appearance of the terms or meaning of certain words that are considered important and supports the goals of the research, in this case is the translation of words, phrases, sentences in the source language (English into the target language (Indonesian. As its criterion, dictionaries was used and rules of contextual translation was applied. It can be concluded that children's stories emphasize the style and meaning contained in it, so the translation is done must consider the context of the story.

  2. Dark Ages Religious Conflicts and their Literary Representations: The Winter King, by Bernard Cornwell

    Directory of Open Access Journals (Sweden)

    Carlos A. Sanz Mingo

    2011-07-01

    Full Text Available This paper analyses the religious situation in Britain in the fifth and sixth centuries as reflected in Arthurian literature. This reflection usually depicts religious strife which brought a political division between the British kingdoms. This, in turn, provoked the final defeat against the Anglo-Saxons. Four religious creeds will be dealt with: the native Celtic religion and the cults that the Romans brought with them from the Eastern Mediterranean, including Christianity and the mysteries of Isis and Mithras. All of them are represented in Bernard Cornwell’s trilogy The WarlordChronicles. We will concentrate on how these creeds influenced the lives of Britons in the agerepresented and exemplified in the first book of Conrnwell’s trilogy, The Winter King. Despite thefact that religion has always been one of the most common topics in Arthuriana, modern literaturedeals with it in a different way to previous texts, linking it with history and politics.

  3. A lethal neurotoxic protein from Indian king cobra (Ophiophagus hannah) venom.

    Science.gov (United States)

    De, Pallabi; Dasgupta, S C; Gomes, A

    2002-12-01

    A lethal neurotoxin protein (Toxin CM36) was isolated and purified from the Indian King Cobra (Ophiophagus hannah) venom by CM-Sephadex ion exchange chromatography and HPLC. The purified toxin had a SDS-molecular weight of 15 +/- 0.5 kD. The UV absorption spectra of Toxin CM36 showed a peak at 280 nm and an Emax at 343.8 nm, when excited at 280 nm fluorescence. Toxin CM36 had an LD50 of 3.5 microg/20 g (i.v.) in male albino mice. It exhibited neurotoxicity and produced irreversible blockade of isolated chick biventer cervicis and rat phrenic nerve diaphragm. The neurotoxicity was found to be Ca2+ dependent. Toxin CM36 had no significant effect on isolated guineapig heart and auricle. It also had no effect on blood pressure of cat and rat but produced respiratory apnoea in rat and guineapig. Toxin CM36 lacked phospholipase activity.

  4. Towards A Minimum Conceptualisation Of Ethical Organisational Change: The Platform Provided By The "King II" Report

    Directory of Open Access Journals (Sweden)

    C. L. Van Tonder

    2006-11-01

    Full Text Available Despite the fact that organisational change is one of the most frequently recurring organisational phenomena of our time, organisations do not succeed at instituting change processes effectively and dismal change "success rates" are recorded. Van Tonder and Van Vuuren (2004 suggested that the adoption of an ethical framework would significantly mitigate the implicit risk of change practices and reduce the negative consequences of such change initiatives. The literature on ethical change practices however is exceedingly sparse and offers little guidance to management on how to conduct change practices ethically. This study argues that the King II report on corporate governance indirectly yet substantially informs issues of governance, risk and ethics in change management and provides a useful point of departure for establishing ethical change practices.

  5. Business ethics and corporate governance in the Second King Report: Farsighted or futile?

    Directory of Open Access Journals (Sweden)

    G.J. Rossouw

    2002-08-01

    Full Text Available The relationship between corporate governance and business ethics has always been ambiguous. Does corporate governance per definition have an ethical nature or is it merely self-interested? Is business ethics an integral part of corporate governance or is it marginalised or even excluded by the debate on corporate governance? Does corporate governance also include the governance of ethics? This article will focus on the relationship between corporate governance and business ethics from the perspective of a developing country. More specifically, it will look at a recent development in South Africa where the Second Report on Corporate Governance for South Africa (IOD, 2002, also known as the Second King Report, gave particular prominence to business ethics. The motivation for its emphasis on business ethics as well as its guidelines for the corporate governance of ethics will be explored and, in conclusion, critically reviewed.

  6. Integration of computer technology into the medical curriculum: the King's experience

    Directory of Open Access Journals (Sweden)

    Vickie Aitken

    1997-12-01

    Full Text Available Recently, there have been major changes in the requirements of medical education which have set the scene for the revision of medical curricula (Towle, 1991; GMC, 1993. As part of the new curriculum at King's, the opportunity has been taken to integrate computer technology into the course through Computer-Assisted Learning (CAL, and to train graduates in core IT skills. Although the use of computers in the medical curriculum has up to now been limited, recent studies have shown encouraging steps forward (see Boelen, 1995. One area where there has been particular interest is the use of notebook computers to allow students increased access to IT facilities (Maulitz et al, 1996.

  7. Problematizing gender identity from Feminist Research in a Drag King experience

    Directory of Open Access Journals (Sweden)

    Roberto Fernández Droguett

    2014-12-01

    Full Text Available This paper presents an experience of Feminist Research developed within the course Methodological Innovations in Qualitative Research, taught in the career of Psychology at the University of Chile. The research consisted of a autoethnography of a Drag-King experience developed in three public places in the city of Santiago in Chile, and our purpose here is to discuss the joint between the methodology developed and the feminist epistemological perspective. Based on a collaborative dialogue we analyse some results of this research and the methodological decisions that were taken during the process. The focus of analysis is the creation of an ambiguous identity that stresses the social norms and allows its critical review, while producing at the same time a complex physical and emotional experience that challenges not only to the persons but also the ways of accounting that through specific narratives.

  8. Aetiology of chronic diarrhoea in children: experience at King Khalid University Hospital, Riyadh, Saudi Arabia.

    Science.gov (United States)

    Abdullah, A M

    1994-01-01

    Forty-eight cases of chronic diarrhoea in children seen at King Khalid University Hospital over a 5-year period were analysed. The mean age at presentation was 1.8 years (range 0.08-10 years); 34 were boys and 14 girls. Forty-four patients were Saudi and four were non-Saudi Arabs. Most children presented with failure to thrive and pallor. The aetiological factors identified were: the post-gastro-enteritis syndrome with or without lactose intolerance in 16 (33%); coeliac disease in ten (21%); congenital chloride diarrhoea in five (10%); glucose-galactose malabsorption and acrodermatitis enteropathica, each in three (6%); ulcerative colitis, intestinal lymphangiectasia, cow's milk protein intolerance and ataxia telangiectasia, each in two (4%); and giardiasis, immune deficiency and cystic fibrosis, each in one (2%). Five children died.

  9. Mechanistic origin of dragon-kings in a population of competing agents

    Science.gov (United States)

    Johnson, N.; Tivnan, B.

    2012-05-01

    We analyze the mechanistic origins of the extreme behaviors that arise in an idealized model of a population of competing agents, such as traders in a market. These extreme behaviors exhibit the defining characteristics of `dragon-kings'. Our model comprises heterogeneous agents who repeatedly compete for some limited resource, making binary choices based on the strategies that they have in their possession. It generalizes the well-known Minority Game by allowing agents whose strategies have not made accurate recent predictions, to step out of the competition until their strategies improve. This generates a complex dynamical interplay between the number V of active agents (mimicking market volume) and the imbalance D between the decisions made (mimicking excess demand). The wide spectrum of extreme behaviors which emerge, helps to explain why no unique relationship has been identified between the price and volume during real market crashes and rallies.

  10. Philip King Brown and Arequipa Sanatorium: early occupational therapy as medical and social experiment.

    Science.gov (United States)

    Harley, Lilas; Schwartz, Kathleen Barker

    2013-01-01

    Historical inquiry enriches occupational therapy practice by identifying enduring values and inspiring future excellence. This study presents for the first time the pioneering life and work of Philip King Brown, a San Francisco physician who used occupation to treat the physical, mental, and social effects of tuberculosis (TB) at Arequipa Sanatorium, the institution he founded in 1911. Through textual analysis of the Arequipa Sanatorium Records, this article evaluates and defends Brown's assertion that his institution was medically and socially experimental. The Arequipa Sanatorium promoted occupational therapy by demonstrating its viability in the treatment of TB, the era's most critical health threat. It also put into practice the ideals of holism, humanism, and occupational justice that resonate within the profession today. Finally, Arequipa provided an example of how an occupation program can change the public perception of disability.

  11. Holocene environmental change according to lake core in Fildes Peninsula of King George Island, Antarctica

    Institute of Scientific and Technical Information of China (English)

    李小梅; 袁宝印; 赵俊琳

    2002-01-01

    Lake core sampled from Xihu in Fildes Peninsula of King Gorge Island, Antarctica could reveal the environmental change of the district. The lake core(GA7) , 9.28 meters long ,was sectioned at an interval of 2 cm. Through measuring the organic carbon, magnetic susceptibility, granularity and organic carbon isotope of GA7, by use of 14C age it was estimated that there were four periods of high temperature in Fildes Peninsula: 4800-4400 aB.P., 3600-3350 aB.P.,2100-1800 aB.P. and 900 aB.P. - present. Meanwhile, results showed that there was a strikingly positive correlation between the content of organic carbon and that of organic carbon isotope(δC13org) which could be the substitute indicators of environmental temperature.

  12. Development of Antarctic herb tundra vegetation near Arctowski station, King George Island

    Science.gov (United States)

    Kozeretska, I. A.; Parnikoza, I. Yu.; Mustafa, O.; Tyschenko, O. V.; Korsun, S. G.; Convey, P.

    2010-01-01

    We studied the development of the Antarctic herb tundra vegetation formation in relation to the history of deglaciation across a range of habitats near H. Arctowski Research Station (King George Island, South Shetland Islands). Across the three identified environmental zones (coastal, intermediate, periglacial), we quantified the total vegetation cover, cover of the two indigenous flowering plants and bryophytes, age structure and reproductive features of the two flowering plants, and species diversity of mosses and liverworts. Analysis of these data supported the recognition of the three environmental zones; however, there were few indications of systematic differences in biological features of the two higher plants across the three zones, generally supporting the view that these, and the grass Deschampsia antarctica in particular, are effective primary colonists of recently deglaciated ground in this region.

  13. King Solomon's Silver? Southern Phoenician Hacksilber Hoards and the Location of Tarshish

    Directory of Open Access Journals (Sweden)

    Christine M. Thompson

    2013-10-01

    Full Text Available Evidence from silver hoards found in Phoenicia is linking Tarshish, the legendary source of King Solomon's silver, to ores in the western Mediterranean. Biblical passages sometimes describe this lost land as a supplier of metals (especially silver to Phoenician sailors who traded in the service of Solomon and Hiram of Tyre in the 10th century BC. Classical authors similarly attribute the mercantile supremacy of the Phoenicians to their command of lucrative supplies of silver in the west, before they colonised the coasts and islands of its metalliferous regions around 800 BC. Conservative rejections of such reports have correctly emphasised a lack of evidence from silver. Lead isotope analyses of silver hoards found in Phoenicia now provide the initial evidence for pre-colonial silver-trade with the west; ore-provenance data correlate with the ancient documents that indicate both Sardinia and Spain as suppliers, and Sardinia as the island of Tarshish.

  14. 悼罗伯特·K.默顿%In Memory of Robeot King Merton

    Institute of Scientific and Technical Information of China (English)

    林聚任

    2003-01-01

    @@ 当我得知美国著名社会学家罗伯特·金·默顿(Robert King Merton)2003年2月23日在纽约不幸去世的消息后,心情十分悲痛.回想几个月前他还在耐心地解答我通过电子邮件提出的问题,现在却离我们而去了.他的谢世,用其学生、现任哥伦比亚大学教务长乔纳森·科尔(Jonathan R.Cole)的话说就是“标志着20世纪社会学发展的一个阶段的终结”.……

  15. Gunshot wounds to the hand. The Martin Luther King, Jr, General Hospital experience.

    Science.gov (United States)

    Phillips, P; Hansraj, K K; Cox, E E; Ashley, E M

    1995-01-01

    This article is a retrospective review of patients who presented to Martin Luther King, Jr./Drew Medical Center with gunshot wounds and had either isolated or associated injuries to the hand. The following is an account of those injuries noting the location, soft-tissue or bony involvement, and interventional methods that were implemented in the treatment of these patients who resided primarily in South Central Los Angeles. Prompt evaluation and initiation of treatment is essential in the management of both high- and low-velocity gunshot wounds so as to decrease the potential morbidity that often follows. Society must also look at the prevalence of these injuries and address the underlying issues that often are the root of the acts of violence.

  16. Lloyd Llewellyn Jones. King and Court in Ancient Persia, 559-331 BCE

    OpenAIRE

    Nunn, Astrid

    2017-01-01

    L. Llewellyn-Jones analyse la cour achéménide sous un aspect politique et social. Dans un premier chapitre l’A. s’attache au « Grand Roi et ses hommes » (p. 12-41). Le second chapitre est dédié aux institutions (“Pomp and Circumstance: Monarchy on Display”, p. 42-73) et le troisième à l’apanage du roi en route (“The Great King in His Empire: The Movable Court”, p. 74-95). Les deux derniers chapitres sont sociaux-culturels et traitent du harem et des femmes (p. 96-122) ainsi que des plaisirs e...

  17. Knowledge and attitudes of dental interns toward denture adhesives in King Saud University, Riyadh, Saudi Arabia.

    Science.gov (United States)

    Al Taweel, Sara Mohammad; Al Shehri, Huda Ahmed

    2016-01-01

    The objective of this study was to evaluate the knowledge and attitudes of dental interns at King Saud University College of Dentistry (KSUCD) regarding denture adhesives (DAs). Surveys were distributed to dental interns at KSUCD (n = 100). Cross-tabulations with the Pearson-™s Chi-square test were used to compare variables using the Statistical Package for Social Sciences (P ≤ 0.05). Approximately, 85.5% of the respondents had learned about DAs as part of their undergraduate curriculum, 71% agree that DAs can be a beneficial adjunct in the fabrication of dentures, and 87% agree that dentists should routinely inform all denture patients of the proper use and misuse of DAs. Most of the participants have adequate knowledge and attitude toward DAs.

  18. Salmon Supplementation Studies in Idaho Rivers; Field Activities Conducted on Clear and Pete King Creeks, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Gass, Carrie; Olson, Jim M. (US Fish and Wildlife Service, idaho Fishery Resource Office, Ahsahka, ID)

    2004-11-01

    In 2001 the Idaho Fisheries Resource Office continued as a cooperator on the Salmon Supplementation Studies in Idaho Rivers (ISS) project on Pete King and Clear creeks. Data relating to supplementation treatment releases, juvenile sampling, juvenile PIT tagging, brood stock spawning and rearing, spawning ground surveys, and snorkel surveys were used to evaluate project data points and augment past data. Due to low adult spring Chinook returns to Kooskia National Fish Hatchery (KNFH) in brood year 1999 there was no smolt supplementation treatment release into Clear Creek in 2001. A 17,014 spring Chinook parr supplementation treatment (containing 1000 PIT tags) was released into Pete King Creek on July 24, 2001. On Clear Creek, there were 412 naturally produced spring Chinook parr PIT tagged and released. Using juvenile collection methods, Idaho Fisheries Resource Office staff PIT tagged and released 320 naturally produced spring Chinook pre-smolts on Clear Creek, and 16 natural pre-smolts on Pete King Creek, for minimum survival estimates to Lower Granite Dam. There were no PIT tag detections of brood year 1999 smolts from Clear or Pete King creeks. A total of 2261 adult spring Chinook were collected at KNFH. Forty-three females were used for supplementation brood stock, and 45 supplementation (ventral fin-clip), and 45 natural (unmarked) adults were released upstream of KNFH to spawn naturally. Spatial and temporal distribution of 37 adults released above the KNFH weir was determined through the use of radio telemetry. On Clear Creek, a total of 166 redds (8.2 redds/km) were observed and data was collected from 195 carcasses. Seventeen completed redds (2.1 redds/km) were found, and data was collected data from six carcasses on Pete King Creek.

  19. Map Showing Limits of Tahoe Glaciation in Sequoia and Kings Canyon National Parks, California

    Science.gov (United States)

    Moore, James Gregory; Mack, Gregory S.

    2008-01-01

    The latest periods of extensive ice cover in the Sierra Nevada include the Tahoe glaciation followed by the Tioga glaciation, and evidence for these ice ages is widespread in the Sequoia and Kings Canyon National Parks area. However, the timing of the advances and retreats of the glaciers during the periods of glaciation continues to be a matter of debate. A compilation of existing work (Clark and others, 2003) defines the Tioga glaciation at 14-25 thousand years ago and splits the Tahoe glaciation into two stages that range from 42-50 and 140-200 thousand years ago. The extent of the Tahoe ice mass shown in the map area is considered to represent the younger Tahoe stage, 42-50 thousand years ago. Evidence of glaciations older than the Tahoe is limited in the southern Sierra Nevada. After the Tioga glaciation, only minor events with considerably less ice cover occurred. The Tioga glaciation was slightly less extensive than the Tahoe glaciation, and each covered about half of the area of Sequoia and Kings Canyon National Parks. The Tahoe glaciers extended 500-1,000 ft lower and 0.5-1.2 mi farther down valleys. Evidence for the Tahoe glacial limits is not as robust as that for Tioga, but the extent of the Tahoe ice is mapped because it covered a larger area and the ice did leave prominent moraines (piles of sediment and boulders deposited by glaciers as they melted at their margins) lower on the east front of the range. Current Sierra redwood (Sequoiadendron giganteum) groves occur in a belt on the west side of the Sierra Nevada, generally west of the area of Tahoe glaciation.

  20. Web Site of King Faysal for Researches and Islamic Studies :Evaluative Case Study . 1

    Directory of Open Access Journals (Sweden)

    Hind Badi Aly al-Badi

    2007-03-01

    Full Text Available This study makes evaluation to the website of King Faisal Islamic Study & Research Center (KFISRC in relation to its site, advanced design, services rendered, public users and easy-to-search including its discharged duties; content, form and scope.The study aims to evaluate the website of KFISRC published in the Internet as well as the volume of its sample users, and to determine the motivations of use.The study was conducted on the Second Semester in 1426H. / 2005G. The researcher has relied in the evaluation case study on "on-line access" in the Internet; a matter which was imposed by the nature and objectives of the study and followed by an evaluation-analysis methodology based on the measures derived from Website & Information Resources Measures in the Internet. The information were gathered using the questionnaire forms which were distributed to a random sample of 15% of the society slide subject of the study totaling 1755 of post-graduate female students; i.e. Master degree; enrolled in Library & Information, Arabic Language and History Departments of Faculty of Arts & Humanities , King Abdulaziz University, Jeddah; and post-graduate female students; i.e. Master degree; enrolled in Faculty of Da'wa & Fundamentals of Religion, Umm Al-Qura University, Makkah Al-Mukarramah, including male and female staff of KFISRC. The study has reached to the number of findings, mainly as follows:The volume of the users has reached to 40.7% of the sampling. One of the reasons of the decreasing percentage in the number of the site users of KFISRC is that 32.4% did not know about the existence of the site in the Internet; whereas, 24.1% of the sampling whose most important motivation to use the site is to know whether the resources searched by them would be available in the data-bases of the KFISRC or not