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Sample records for dysprosium 158

  1. First search for double $\\beta$ decay of dysprosium

    CERN Document Server

    Belli, P; Cappella, F; Cerulli, R; Danevich, F A; d'Angelo, S; Di Vacri, M L; Incicchitti, A; Laubenstein, M; Nagorny, S S; Nisi, S; Tolmachev, A V; Tretyak, V I; Yavetskiy, R P

    2011-01-01

    A search for double $\\beta$ decay of dysprosium was realized for the first time with the help of an ultra low-background HP Ge $\\gamma$ detector. After 2512 h of data taking with a 322 g sample of dysprosium oxide limits on double beta processes in $^{156}$Dy and $^{158}$Dy have been established on the level of $T_{1/2}\\geq 10^{14}-10^{16}$ yr. Possible resonant double electron captures in $^{156}$Dy and $^{158}$Dy were restricted on a similar level. As a by-product of the experiment we have measured the radioactive contamination of the Dy$_2$O$_3$ sample and set limits on the $\\alpha$ decay of dysprosium isotopes to the excited levels of daughter nuclei as $T_{1/2}\\geq 10^{15} - 10^{17}$ yr.

  2. Dysprosium magneto-optical traps

    CERN Document Server

    Youn, Seo Ho; Ray, Ushnish; Lev, Benjamin L

    2010-01-01

    Magneto-optical traps (MOTs) of highly magnetic lanthanides open the door to explorations of novel phases of strongly correlated matter such as lattice supersolids and quantum liquid crystals. We recently reported the first MOTs of the five high abundance isotopes of the most magnetic atom, dysprosium. Described here are details of the experimental technique employed for repumper-free Dy MOTs containing up to half a billion atoms. Extensive characterization of the MOTs' properties---population, temperature, loading, metastable decay dynamics, trap dynamics---is provided.

  3. On polymorphism of dysprosium trichloride

    Energy Technology Data Exchange (ETDEWEB)

    Zakiryanova, Irina D.; Khokhlov, Vladimir A.; Salyulev, Alexander B.; Korzun, Iraida V. [RAS Ural Branch, Ekaterinburg (Russian Federation). Institute of High-Temperature Electrochemistry

    2015-07-01

    For the first time, the structure of crystalline DyCl{sub 3} over a wide temperature range from room temperature to melting point was studied by Raman spectroscopy. The phonon modes (cm{sup -1}) of dysprosium trichloride (monoclinic crystal lattice of AlCl{sub 3} type, Z = 4, CN = 6) at room temperature are 257 (A{sub 1g}), 201 (E{sub g}), 112 (E{sub g}), 88 (A{sub 1g}), and 63 (E{sub g}). The monoclinic structure of the crystalline DyCl{sub 3} C{sub 2h}{sup 3} symmetry was found to remain constant over the studied temperature range. No polymorphic transformation in the solid state was detected. Gravimetry, calorimetry, and mass spectrometry have been used in addition to support the conclusions made on the basis of Raman spectroscopic data.

  4. Resonance ionization spectroscopy in dysprosium

    Energy Technology Data Exchange (ETDEWEB)

    Studer, D., E-mail: dstuder@uni-mainz.de; Dyrauf, P.; Naubereit, P.; Heinke, R.; Wendt, K. [Johannes Gutenberg-Universität Mainz, Institut für Physik (Germany)

    2017-11-15

    We report on resonance ionization spectroscopy (RIS) of high-lying energy levels in dysprosium. We developed efficient excitation schemes and re-determined the first ionization potential (IP) via analysis of Rydberg convergences. For this purpose both two- and three-step excitation ladders were investigated. An overall ionization efficiency of 25(4) % could be demonstrated in the RISIKO mass separator of Mainz University, using a three-step resonance ionization scheme. Moreover, an extensive analysis of the even-parity 6sns- and 6snd-Rydberg-series convergences, measured via two-step excitation was performed. To account for strong perturbations in the observed s-series, the approach of multichannel quantum defect theory (MQDT) was applied. Considering all individual series limits we extracted an IP-value of 47901.76(5) cm{sup −1}, which agrees with the current literature value of 47901.7(6) cm{sup −1}, but is one order of magnitude more precise.

  5. The dysprosium-tin phase diagram

    Energy Technology Data Exchange (ETDEWEB)

    Eremenko, V.N.; Bulanova, M.V.; Martsenjuk, P.S. (I.N. Frantsevich Inst. for Problems of Materials Science, Kiev (Ukraine))

    1992-12-07

    The dysprosium-tin phase diagram was established by means of differential thermal, X-ray and microscopic analyses of 22 alloys. Seven intermetallic compounds were found to exist in the system. Dy[sub 5]Sn[sub 3] melts congruently at 1870 degC, and undergoes a polymorphous transformation at 1823 [+-] 6 degC. The intermetallics Dy[sub 5]Sn[sub 4], Dy[sub 11]Sn[sub 10], DySn, Dy[sub 4]Sn[sub 5], DySn[sub 2], DySn[sub 3] are formed peritectically at 1712 [+-]11, 1605 [+-]12, 1208 [+-]3, 1166 [+-]7, 1138 [+-]3 and 747 [+-]6 degC respectively. DySn[sub 3] exists in a narrow temperature range, in two polymorphous modifications. The transformation [beta]-DySn[sub 3] [yields] [alpha]-DySn[sub 3] occurs at 608 [+-] 12 degC, and at 499 [+-]2 degC [alpha]-DySn[sub 3] decomposes to DySn[sub 2] and the tin-rich melt. The dysprosium-rich eutectic crystallizes at 1204 [+-]10 degC and contains 13 at.% tin. The solid-state solubility of tin in dysprosium is about 3 at.%, and that of dysprosium in tin is negligible.

  6. Towards a new measurement of parity violation in dysprosium

    CERN Document Server

    Leefer, N; Antypas, D; Budker, D

    2014-01-01

    The dysprosium parity violation experiment concluded nearly 17 years ago with an upper limit on weak interaction induced mixing of nearly degenerate, opposite parity states in atomic dysprosium. While that experiment was limited in sensitivity by statistics, a new apparatus constructed in the interim for radio-frequency spectroscopy is expected to provide significant improvements to the statistical sensitivity. Preliminary work from the new PV experiment in dysprosium is presented with a discussion of the current statistical sensitivity and outlook.

  7. Dysprosium Modification of Cobalt Ferrite Ionic Magnetic Fluids

    Institute of Scientific and Technical Information of China (English)

    JIANG Rong-li; LIU Yong-chao; GENG Quan-rong; ZHAO Wen-tao

    2005-01-01

    Dysprosium composite cobalt ferrite ionic magnetic fluids were prepared by precipitation in the presence of Tri-sodium citrate. Influence of dysprosium modification on magnetic property is studied. The result shows that magnetic response toward exterior magnetic field can be improved by adding Dy3+. Studies also show that the increase of reaction temperature may improve the modification effect of dysprosium. By adding dysprosium ions, the average diameter of the magnetic nanoparticles will be decreased evidently. It is clear that the particles appear as balls, Cobalt ferrite with sizes of 12-15 nm, rare earth composite cobalt ferrite with sizes of 6-8 nm.

  8. Can a dysprosium shortage threaten green energy technologies?

    NARCIS (Netherlands)

    Hoenderdaal, S.; Tercero Espinoza, L.; Marschneider-Weidemann, F.; Crijns - Graus, Wina

    2013-01-01

    Dysprosium, one of the various rare earth elements, is currently for more than 99% mined in China. As China is reducing its exports, new mining projects outside of China are needed to sustain supply and meet future demands. Dysprosium is mainly used in permanent magnets to retain the magnet's streng

  9. Phenalenyl-based mononuclear dysprosium complexes

    Directory of Open Access Journals (Sweden)

    Yanhua Lan

    2016-07-01

    Full Text Available The phenalenyl-based dysprosium complexes [Dy(PLN2(HPLNCl(EtOH] (1, [Dy(PLN3(HPLN]·[Dy(PLN3(EtOH]·2EtOH (2 and [Dy(PLN3(H2O2]·H2O (3, HPLN being 9-hydroxy-1H-phenalen-1-one, have been synthesized. All compounds were fully characterized by means of single crystal X-ray analysis, paramagnetic 1H NMR, MALDI-TOF mass spectrometry, UV–vis spectrophotometry and magnetic measurements. Both static (dc and dynamic (ac magnetic properties of these complexes have been investigated, showing slow relaxation of magnetization, indicative of single molecule magnet (SMM behavior. Attempts to synthesize sublimable phenalenyl-based dysprosium complexes have been made by implementing a synthetic strategy under anhydrous conditions. The sublimed species were characterized and their thermal stability was confirmed. This opens up the possibility to deposit phenalenyl-based lanthanides complexes by sublimation onto surfaces, an important prerequisite for ongoing studies in molecular spintronics.

  10. Anisotropy in the Interaction of Ultracold Dysprosium

    CERN Document Server

    Kotochigova, Svetlana

    2011-01-01

    The nature of the interaction between ultracold atoms with a large orbital and spin angular momentum has attracted considerable attention. It was suggested that such interactions can lead to the realization of exotic states of highly correlated matter. Here, we report on a theoretical study of the competing anisotropic dispersion, magnetic dipole-dipole, and electric quadrupole-quadrupole forces between two dysprosium atoms. Each dysprosium atom has an orbital angular momentum L=6 and magnetic moment $\\mu=10\\mu_B$. We show that the dispersion coefficients of the ground state adiabatic potentials lie between 1865 a.u. and 1890 a.u., creating a non-negligible anisotropy with a spread of 25 a.u. and that the electric quadrupole-quadrupole interaction is weak compared to the other interactions. We also find that for interatomic separations $R< 50\\,a_0$ both the anisotropic dispersion and magnetic dipole-dipole potential are larger than the atomic Zeeman splittings for external magnetic fields of order 10 G to ...

  11. Neutron resonance parameters of dysprosium isotopes using neutron capture yields

    Energy Technology Data Exchange (ETDEWEB)

    Shin, S. G.; Kye, Y. U.; Cho, M. H. [POSTECH, Pohang (Korea, Republic of); Namkung, W. [Pohang Accelerator Laboratory, Pohang (Korea, Republic of); Kim, G. N. [Kyungpook National University, Daegu (Korea, Republic of); Lee, M. W.; Kang, Y. R. [Dongnam Inst. Of Radiological and Medical Science, Busan (Korea, Republic of)

    2015-10-15

    Dysprosium is used in the field of nuclear reactor system because it has a very large thermal neutron absorption cross-section. The dysprosium alloyed with special stainless steels is attractive for control in nuclear reactor because of the ability to absorb neutrons readily without swelling or contracting over time and its high melting point. Dysprosium is also one of fission products from the thermal fission of {sup 234}U, {sup 233}U, and {sup 239}Pu. The fission products are accumulated in the reactor core by the burn-up of the nuclear fuel and the poison effect is increased. Therefore, it is required to understand how Dysprosium as both a poison and an absorbing material in the control rod has an effect on the neutron population in a nuclear reactor system over all energy regions. Neutron Capture experiments on Dy isotopes were performed at the electron linear accelerator (LINAC) facility of the Rensselear Polytechnic Institute (RPI) in the neutron energy region from 10 eV to 1 keV. Resonance parameters were extracted by fitting the neutron capture data using the SAMMY multilevel R-matrix Bayesian code.

  12. Properties of Polydisperse Tin-doped Dysprosium and Indium Oxides

    Directory of Open Access Journals (Sweden)

    Malinovskaya Tatyana

    2017-01-01

    Full Text Available The results of investigations of the complex permittivity, diffuse-reflectance, and characteristics of crystal lattices of tin-doped indium and dysprosium oxides are presented. Using the methods of spectroscopy and X-ray diffraction analysis, it is shown that doping of indium oxide with tin results in a significant increase of the components of the indium oxide complex permittivity and an appearance of the plasma resonance in its diffuse-reflectance spectra. This indicates the appearance of charge carriers with the concentration of more than 1021 cm−3 in the materials. On the other hand, doping of the dysprosium oxide with the same amount of tin has no effect on its optical and electromagnetic properties.

  13. Dysprosium titanate as an absorber material for control rods

    Science.gov (United States)

    Risovany, V. D.; Varlashova, E. E.; Suslov, D. N.

    2000-09-01

    Disprosium titanate is an attractive control rod material for the thermal neutron reactors. Its main advantages are: insignificant swelling, no out-gassing under neutron irradiation, rather high neutron efficiency, a high melting point (˜1870°C), non-interaction with the cladding at temperatures above 1000°C, simple fabrication and easily reprocessed non-radioactive waste. It can be used in control rods as pellets and powder. The disprosium titanate control rods have worked off in the MIR reactor for 17 years, in VVER-1000 - for 4 years without any operating problems. After post-irradiation examinations this type of control rod having high lifetime was recommended for the VVER and RBMK. The paper presents the examination results of absorber element dummies containing dysprosium titanate, irradiated in the SM reactor to the neutron fluence of 3.4×10 22 cm -2 ( E>0.1 MeV) and, also, the data on structure, thermal-physical properties of dysprosium titanate, efficiency of dysprosium titanate control rods.

  14. Dysprosium electrodeposition from a hexaalkylguanidinium-based ionic liquid

    Science.gov (United States)

    Berger, Claudia A.; Arkhipova, Maria; Maas, Gerhard; Jacob, Timo

    2016-07-01

    The rare-earth element dysprosium (Dy) is an important additive that increases the magnetocrystalline anisotropy of neodymium magnets and additionally prevents from demagnetizing at high temperatures. Therefore, it is one of the most important elements for high-tech industries and is mainly used in permanent magnetic applications, for example in electric vehicles, industrial motors and direct-drive wind turbines. In an effort to develop a more efficient electrochemical technique for depositing Dy on Nd-magnets in contrast to commonly used costly physical vapor deposition, we investigated the electrochemical behavior of dysprosium(iii) trifluoromethanesulfonate in a custom-made guanidinium-based room-temperature ionic liquid (RTIL). We first examined the electrodeposition of Dy on an Au(111) model electrode. The investigation was carried out by means of cyclic voltammetry (CV) and X-ray photoelectron spectroscopy (XPS). The initial stages of metal deposition were followed by in situ scanning tunneling microscopy (STM). CV measurements revealed a large cathodic reduction peak, which corresponds to the growth of monoatomic high islands, based on STM images taken during the initial stages of deposition. XPS identified these deposited islands as dysprosium. A similar reduction peak was also observed on an Nd-Fe-B substrate, and positively identified as deposited Dy using XPS. Finally, we varied the concentration of the Dy precursor, electrolyte flow and temperature during Dy deposition and demonstrated that each of these parameters could be used to increase the thickness of the Dy deposit, suggesting that these parameters could be tuned simultaneously in a temperature-controlled flow cell to enhance the thickness of the Dy layer.The rare-earth element dysprosium (Dy) is an important additive that increases the magnetocrystalline anisotropy of neodymium magnets and additionally prevents from demagnetizing at high temperatures. Therefore, it is one of the most important

  15. 30 CFR 15.8 - Quality assurance.

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    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality assurance. 15.8 Section 15.8 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF... § 15.8 Quality assurance. (a) Applicants granted an approval or an extension of approval under...

  16. 40 CFR 158.350 - Certified limits.

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    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Certified limits. 158.350 Section 158... REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.350 Certified limits. The applicant must propose certified limits for the ingredients in the product. Certified limits become legally binding limits upon...

  17. 21 CFR 158.3 - Definitions.

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    2010-04-01

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    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Skin diving. 15.8 Section 15.8 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.8 Skin diving. Diving with camera, or diving for observation and pleasure is permitted and encouraged within...

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    2010-10-01

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  20. 14 CFR 158.83 - Informal resolution.

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    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Informal resolution. 158.83 Section 158.83... PASSENGER FACILITY CHARGES (PFC'S) Termination § 158.83 Informal resolution. The Administrator shall undertake informal resolution with the public agency or any other affected party if, after review...

  1. Dysprosium detector for neutron dosimetry in external beam radiotherapy

    Science.gov (United States)

    Ostinelli, A.; Berlusconi, C.; Conti, V.; Duchini, M.; Gelosa, S.; Guallini, F.; Vallazza, E.; Prest, M.

    2014-09-01

    Radiotherapy treatments with high-energy (>8 MeV) photon beams are a standard procedure in clinical practice, given the skin and near-target volumes sparing effect, the accurate penetration and the uniform spatial dose distribution. On the other hand, despite these advantages, neutrons may be produced via the photo-nuclear (γ,n) reactions of the high-energy photons with the high-Z materials in the accelerator head, in the treatment room and in the patient, resulting in an unwanted dose contribution which is of concern, given its potential to induce secondary cancers, and which has to be monitored. This work presents the design and the test of a portable Dysprosium dosimeter to be used during clinical treatments to estimate the "in vivo" dose to the patient. The dosimeter has been characterized and validated with tissue-equivalent phantom studies with a Varian Clinical iX 18 MV photon beam, before using it with a group of patients treated at the S. Anna Hospital in Como. The working principle of the dosimeter together with the readout chain and the results in terms of delivered dose are presented.

  2. Dysprosium detector for neutron dosimetry in external beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ostinelli, A.; Berlusconi, C.; Conti, V.; Duchini, M.; Gelosa, S. [Medical Physics - Sant' Anna Hospital, Como (Italy); Guallini, F. [EL.SE s.r.l. (Italy); Vallazza, E. [INFN, Trieste (Italy); Prest, M. [University of Insubria, Como (Italy)

    2014-09-21

    Radiotherapy treatments with high-energy (>8MeV) photon beams are a standard procedure in clinical practice, given the skin and near-target volumes sparing effect, the accurate penetration and the uniform spatial dose distribution. On the other hand, despite these advantages, neutrons may be produced via the photo-nuclear (γ,n) reactions of the high-energy photons with the high-Z materials in the accelerator head, in the treatment room and in the patient, resulting in an unwanted dose contribution which is of concern, given its potential to induce secondary cancers, and which has to be monitored. This work presents the design and the test of a portable Dysprosium dosimeter to be used during clinical treatments to estimate the “in vivo” dose to the patient. The dosimeter has been characterized and validated with tissue-equivalent phantom studies with a Varian Clinical iX 18 MV photon beam, before using it with a group of patients treated at the S. Anna Hospital in Como. The working principle of the dosimeter together with the readout chain and the results in terms of delivered dose are presented.

  3. Low Field Magnetic and Thermal Hysteresis in Antiferromagnetic Dysprosium

    Directory of Open Access Journals (Sweden)

    Iuliia Liubimova

    2017-06-01

    Full Text Available Magnetic and thermal hysteresis (difference in magnetic properties on cooling and heating have been studied in polycrystalline Dy (dysprosium between 80 and 250 K using measurements of the reversible Villari effect and alternating current (AC susceptibility. We argue that measurement of the reversible Villari effect in the antiferromagnetic phase is a more sensitive method to detect magnetic hysteresis than the registration of conventional B(H loops. We found that the Villari point, recently reported in the antiferromagnetic phase of Dy at 166 K, controls the essential features of magnetic hysteresis and AC susceptibility on heating from the ferromagnetic state: (i thermal hysteresis in AC susceptibility and in the reversible Villari effect disappears abruptly at the temperature of the Villari point; (ii the imaginary part of AC susceptibility is strongly frequency dependent, but only up to the temperature of the Villari point; (iii the imaginary part of the susceptibility drops sharply also at the Villari point. We attribute these effects observed at the Villari point to the disappearance of the residual ferromagnetic phase. The strong influence of the Villari point on several magnetic properties allows this temperature to be ranked almost as important as the Curie and Néel temperatures in Dy and likely also for other rare earth elements and their alloys.

  4. A Low-Symmetry Dysprosium Metallocene Single-Molecule Magnet with a High Anisotropy Barrier.

    Science.gov (United States)

    Pugh, Thomas; Chilton, Nicholas F; Layfield, Richard A

    2016-09-05

    The single-molecule magnet (SMM) properties of the isocarbonyl-ligated dysprosium metallocene [Cp*2 Dy{μ-(OC)2 FeCp}]2 (1Dy ), which contains a rhombus-shaped Dy2 Fe2 core, are described. Combining a strong axial [Cp*](-) ligand field with a weak equatorial field consisting of the isocarbonyl ligands leads to an anisotropy barrier of 662 cm(-1) in zero applied field. The dominant thermal relaxation pathways in 1Dy involves at least the fourth-excited Kramers doublet, thus demonstrating that prominent SMM behavior can be observed for dysprosium in low-symmetry environments.

  5. Malonate complexes of dysprosium: synthesis, characterization and application for LI-MOCVD of dysprosium containing thin films.

    Science.gov (United States)

    Milanov, Andrian P; Seidel, Rüdiger W; Barreca, Davide; Gasparotto, Alberto; Winter, Manuela; Feydt, Jürgen; Irsen, Stephan; Becker, Hans-Werner; Devi, Anjana

    2011-01-07

    A series of malonate complexes of dysprosium were synthesized as potential metalorganic precursors for Dy containing oxide thin films using chemical vapor deposition (CVD) related techniques. The steric bulkiness of the dialkylmalonato ligand employed was systematically varied and its influence on the resulting structural and physico-chemical properties that is relevant for MOCVD was studied. Single crystal X-ray diffraction analysis revealed that the five homoleptic tris-malonato Dy complexes (1-5) are dimers with distorted square-face bicapped trigonal-prismatic geometry and a coordination number of eight. In an attempt to decrease the nuclearity and increase the solubility of the complexes in various solvents, the focus was to react these dimeric complexes with Lewis bases such as 2,2'-biypridyl and pyridine (6-9). This resulted in monomeric tris-malonato mono Lewis base adduct complexes with improved thermal properties. Finally considering the ease of synthesis, the monomeric nature and promising thermal characteristics, the silymalonate adduct complex [Dy(dsml)(3)bipy] (8) was selected as single source precursor for growing DySi(x)O(y) thin films by liquid injection metalorganic chemical vapor deposition (LI-MOCVD) process. The as-deposited films were analyzed for their morphology and composition by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis, Rutherford backscattering (RBS) analysis and X-ray photoelectron spectroscopy.

  6. Exploration of dysprosium: the most critical element for Japan

    Science.gov (United States)

    Watanabe, Y.

    2012-04-01

    Dysprosium (Dy), one of the heavy rare earth elements, is used mainly as an additive for NdFeB permanent magnets which are installed in various modern industrial products such as voice coil motors in computers, factory automation machinery, hybrid and electric vehicles, home electronics, and wind turbine, to improve heat resistance of the magnets. Dy has been produced about 2,000t per year from the ores from ion adsorption type deposits in southern China. However, the produced amount of Dy was significantly reduced in 2011 in China due to reservation of heavy rare earth resources and protection of natural environment, resulting in soaring of Dy price in the world. In order to respond the increasing demand of Dy, unconventional supply sources are inevitably developed, in addition to heavy rare earth enriched ion adsorption type deposits outside China. Heavy rare earth elements including Dy are dominantly hosted in xenotime, fergusonite, zircon, eudialyte, keiviite, kainosite, iimoriite, etc. Concentration of xenotime is found in placer deposits in Malaysia and India, hydrothermal deposits associated with unconformity-type uranium mineralization (Athabasca basin in Canada, Western Australia), iron-oxide fluorite mineralization (South Africa) and Sn-bearing alkaline granite (Brazil). Zircon and fergusontie concentration is found as igneous and hydrothermal products in peralkaline syenite, alkaline granite and pegmatite (e.g., Nechalacho in Canada). Eudialyte concentration is found in some peralkaline syenite bodies in Greenland, Canada, Sweden and Russia. Among these sources, large Dy resources are estimated in the deposits hosted in peralkaline rocks (Nechalacho: 79,000t, Kvanefjeld: 49,000t, Norra Karr: 15,700t, etc.) compared to the present demand of Dy. Thus, Dy will be supplied from the deposits associated with peralkaline and alkaline deposits in future instead of ion adsorption type deposits in southern China.

  7. Long afterglow of trivalent dysprosium doped strontium aluminate

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Yuan Ming, E-mail: dongshanisland@126.com [School of Mathematics and Physics, Changzhou University, Jiangsu 213164 (China); Ma, Qing-lan [School of Mathematics and Physics, Changzhou University, Jiangsu 213164 (China); School of Electronics and Information, Nantong University, Jiangsu 226019 (China)

    2015-04-15

    Trivalent dysprosium doped strontium aluminate (SrA1{sub 2}O{sub 4}:Dy{sup 3+}) was synthesized via the sol–gel combustion method to realize green afterglow in the absence of Eu{sup 2+} luminescent centers. The morphology, crystal structure, photoluminescence and long afterglow of the SrAl{sub 2}O{sub 4}:Dy{sup 3+} were characterized with scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy and photoluminescence spectroscopy, respectively. The bluish-green photoluminescence of SrAl{sub 2}O{sub 4}:Dy{sup 3+} consists of a broad emission band centered at about 520 nm and two characteristic emissions of Dy{sup 3+} ions centered at 480 and 575 nm, respectively. The green afterglow of SrAl{sub 2}O{sub 4}:Dy{sup 3+} is a broad emission band centered at around 520 nm, and the lifetime extracted from afterglow decay is found to be 53 s. The mechanism on the green afterglow from SrAl{sub 2}O{sub 4}:Dy{sup 3+} is discussed in terms of the possible defect levels in the host. - Highlights: • Broad band long-lasting afterglow is observed in SrAl{sub 2}O{sub 4}:Dy{sup 3+} phosphors. • Characteristic emissions of Dy{sup 3+} ions are superimposed on the broad PL of phosphors. • Dy{sup 3+} ions can also act as luminescent centers in addition to electron traps. • A mechanism on long afterglow of SrAl{sub 2}O{sub 4}:Dy{sup 3+} is proposed without Eu{sup 2+} activator.

  8. Low temperature spin reorientation in dysprosium iron garnet

    Energy Technology Data Exchange (ETDEWEB)

    Lahoubi, M; Younsi, W; Soltani, M L [Department of Physics, Badji-Mokhtar University, BP-12 Annaba, 23000 (Algeria); Voiron, J; Schmitt, D, E-mail: mlahoubi@gmail.co [Louis Neel Laboratory, CNRS-UJF, BP-166, 38042 Grenoble Cedex 9 (France)

    2009-03-01

    The spin reorientation (SR) phase transition in dysprosium iron garnet (Dy{sub 3}Fe{sub 5}O{sub 12} or DyIG) have been studied by specific heat C{sub p}(T) and high field magnetisation measurements M{sub T}(H) and M{sub H}(T) on single crystals at low temperature. A first order SR is observed with a sharp jump at T{sub SR} = 14.5+-0.5 K in the C{sub p}(T) curve which corresponds to a spontaneous change from the high temperature (HT) easy direction (111) to an (uuw) angular low temperature (LT) phases. Above T{sub SR}, the magnetic structure is described by the irreducible representation (IR) A{sub 2g} of the rhombohedral space group R 3 c. Below T{sub SR}, the magnetic structure changes in the monoclinic the space group C2/c with the IR A{sub g}. When the field H is kept aligned along the hard symmetry directions (100) and (110), we obtain respectively the variation of the angular positions theta(T) and theta'(T) from the total spontaneous magnetisation down to 1.5 K (theta = 39.23 deg. and theta' = 30.14 deg.) and the results are in good agreement with the previous observations in low fields. When the sample is allowed to rotate freely on itself, the critical field H{sub c}(T) between the HT(111) and the LT(uuw) angular phases permits us to precise the transition line up to 15 T and 40 K between the so called canted field induced (FI) and the associated collinear magnetic phases. The experimental magnetic phase diagram (MPD) is precisely determined in the (H{sub c}-T) plane and the domains of the existence and the stability of the two magnetic phases are specified.

  9. Anisotropic magnetic properties of dysprosium iron garnet (DyIG)

    Energy Technology Data Exchange (ETDEWEB)

    Lahoubi, M; Younsi, W; Soltani, M-L [Department of Physics, Badji-Mokhtar University, BP 12 - 23000 Annaba (Algeria); Ouladdiaf, B, E-mail: mlahoubi@gmail.co [Institut Laue Langevin, BP 156 - 38042 Grenoble Cedex 9 (France)

    2010-01-01

    The magnetic properties of dysprosium iron garnet (DyIG) have been studied by performing high resolution powder neutron diffraction experiments and high dc fields magnetizations on single crystals. Among all the reflections (hkl) indexed in the nuclear cubic space group (CSG) Ia 3-bar d with h+k+l=2n and k=[000], the superstructure lines (hkl)* forbidden by the symmetry (222)* and (622)* are not observed in the patterns at all temperatures. The pattern at 130 K is well interpreted within the magnetic modes F belonging to the irreducible representation (IR) T{sub 1g} of the CSG and identified to the room temperature ferrimagnetic Neel model. The high magnetic field behavior of the spontaneous collinear magnetic structure (MS) along the easy axis (EA) <111> is isotropic. Below 130 K, the patterns exhibit additional magnetic superstructure lines. They are associated to the appearance of the spontaneous non collinear MS which is described in the subgroup of the CSG, R 3-bar c within the IR A{sub 2g}. A strong magnetization anisotropy (MA) is observed at 1.5 K in the low symmetry phases were the spin reorientation transition (SR) occur at T{sub RS}=14.5 K. The onset of MA is detected below two characteristic temperatures, Ta{sub 1}=125 K and Ta{sub 2}=75 K respectively to the hard axis (HA) <100> and <110>. Symmetry arguments are used in the framework of the theory of representation analysis (RA) applied to the subgroup of R 3-bar c, C2/c within the IR A{sub g}. It seems that this MA results essentially from the difference between the spontaneous non collinear MS and the field induced (FI) configurations. All results are discussed with previous neutrons studies.

  10. Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems

    KAUST Repository

    Arratia-Quijada, Jenny

    2015-10-23

    A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nanoparticles showed a linear relationship with the reciprocal relaxation spin-lattice (T1) time of water protons which is reflected as contrast in aqueous suspensions analyzed by magnetic resonance imaging. The interlayer space of dysprosium containing LDH was successfully intercalated with folate, ibuprofen and gallate ions, which are key molecules for recognition of some cancer cells and treatment of diseases. The paramagnetic property of the dysprosium-containing LDH detected in this work beside the ability to transport drugs open up the opportunity to design theranostic materials in a single crystal phase with nanometric dimensions.

  11. Effects of Dysprosium Oxide Doping on Microstructure and Properties of Barium Titanate Ceramic

    Institute of Scientific and Technical Information of China (English)

    Pu Yongping; Ren Huijun; Chen Wei; Chen Shoutian

    2005-01-01

    Different amounts of dysprosium oxide were incorporated into barium titanate powders synthesized by hydrothermal method. Relations of substitution behaviors and lattice parameters with solid-solubility were studied. Furthermore, the influences of dysprosium oxide doping fraction on grain size and dielectric properties of barium titanate ceramic, including dielectric constant and breakdown electric field strength, were investigated via scanning electron microscope, X-ray diffraction and electric property tester. The results show that dysprosium oxide can restrain abnormal grain growth during sintering and that fine-grained and high density of barium titanate ceramic can result in excellent dielectric properties. As mass fraction of dysprosium oxide is 0.6%, the lattice parameters of grain increase to the maximum because of the lowest vacancy concentration. The electric property parameters are cited as following: dielectric constant (25 ℃) reaches 4100, the change in relative dielectric constant with temperature is -10% to 10% within the range of -15~100 ℃, breakdown electric field strength (alternating current) achieves 3.2 kV·mm-1, which can be used in manufacturing high voltage ceramic capacitors.

  12. Sandwich-type tetrakis(phthalocyaninato) dysprosium-cadmium quadruple-decker SMM.

    Science.gov (United States)

    Wang, Hailong; Qian, Kang; Wang, Kang; Bian, Yongzhong; Jiang, Jianzhuang; Gao, Song

    2011-09-14

    Homoleptic tetrakis[2,3,9,10,16,17,23,24-octa(butyloxy)phthalocyaninato] dysprosium-cadmium quadruple-decker complex 1 was isolated in relatively good yield of 43% from a simple one-pot reaction. This compound represents the first sandwich-type tetrakis(phthalocyaninato) rare earth-cadmium quadruple-decker SMM that has been structurally characterized.

  13. In situ characterization of the nitridation of dysprosium during mechanochemical processing

    Energy Technology Data Exchange (ETDEWEB)

    Jaques, Brian J.; Osterberg, Daniel D.; Alanko, Gordon A.; Tamrakar, Sumit; Smith, Cole R.; Hurley, Michael F.; Butt, Darryl P., E-mail: DarrylButt@BoiseState.edu

    2015-01-15

    Highlights: • A nitridation reaction in a high energy planetary ball mill was monitored in situ. • Dysprosium mononitride was synthesized from Dy at low temperatures in short times. • Ideal gas law and in situ temperature and pressure used to assess reaction extent. • It is proposed that reaction rate is proportional to the creation of new surface. - Abstract: Processing of advanced nitride ceramics traditionally requires long durations at high temperatures and, in some cases, in hazardous atmospheres. In this study, dysprosium mononitride (DyN) was rapidly formed from elemental dysprosium in a closed system at ambient temperatures. An experimental procedure was developed to quantify the progress of the nitridation reaction during mechanochemical processing in a high energy planetary ball mill (HEBM) as a function of milling time and intensity using in situ temperature and pressure measurements, SEM, XRD, and particle size analysis. No intermediate phases were formed. It was found that the creation of fresh dysprosium surfaces dictates the rate of the nitridation reaction, which is a function of milling intensity and the number of milling media. These results show clearly that high purity nitrides can be synthesized with short processing times at low temperatures in a closed system requiring a relatively small processing footprint.

  14. Dysprosium complexes with the tetraphenylporphyrin macrocyclic ligand; Complejos de disprosio con el ligante macrociclico tetrafenilporfirina

    Energy Technology Data Exchange (ETDEWEB)

    Martinez M, V.; Padilla, J.; Ramirez, F.M

    1992-04-15

    In this report, the results obtained on the synthesis, characterization and study of the chemical behavior of dysprosium complex with the acetylacetone chelating agent (Hacac) and the tetraphenylporphyrin macrocyclic ligand (H{sub 2}TFP) are given. Based on the literature but according to our necessities and interest, the appropriate methodology settled down from the synthesis of prime matters until the obtaining and characterization of the products. The acetyl acetonate complex was obtained of mono hydrated dysprosium [Dy(acac){sub 3}. H{sub 2}0] and trihydrated [Dy(acac){sub 3} .3 H{sub 2}0], the mono tetra phenyl porphyrinate [Dy(TFP)(acac). 2 ac] the double sandwich of the dysprosium porphyrinate [Dy(TFP){sub 2}] and the triple sandwich of the dysprosium porphyrinate [Dy(TFP){sub 3}. 2 TCB] (TCB = trichlorobenzene). Its were characterized by their melting points, solubility, IR, UV, TGA and DTA both first and besides the techniques already mentioned for NMR'H, RPE and Magnetic susceptibility the three last complexes. From the spectroscopic point of view, IR and RPE its suggested the existence of a complex of inverse mixed valence [Dy(TFP){sup 2-} (TFP) {sup 1-}] for the Dy(TFP){sub 2} as a result of the existence of the free radical (TFP' {sup 1-} and that it was not in none of the other porphyrin compounds. In the NMR'H spectra of the compounds were not observed signals in the region from 0 to 10 ppm that which shows that the dysprosium complexes in special those of the porphyrin type are highly paramagnetic and its could be used as displacement reagents, creators of images and contrast agents of great utility in these days in studies of NMR, technique today by today used in medical diagnoses. (Author)

  15. Synthesis, structural characterization and in vitro testing of dysprosium containing silica particles as potential MRI contrast enhancing agents

    Science.gov (United States)

    Chiriac, L. B.; Trandafir, D. L.; Turcu, R. V. F.; Todea, M.; Simon, S.

    2016-11-01

    The work is focused on synthesis and structural characterization of novel dysprosium-doped silica particles which could be considered as MRI contrast agents. Sol-gel derived silica rich particles obtained via freeze-drying and spray-drying processing methods were structurally characterized by XRD, 29Si MAS-NMR and XPS methods. The occurrence of dysprosium on the outermost layer of dysprosium containing silica particles was investigated by XPS analysis. The MRI contrast agent characteristics have been tested using RARE-T1 and RARE-T2 protocols. The contrast of MRI images delivered by the investigated samples was correlated with their local structure. Dysprosium disposal on microparticles with surface structure characterised by decreased connectivity of the silicate network units favours dark T2-weighted MRI contrast properties.

  16. Dysprosium-containing layered double hydroxides nanoparticles intercalated with biologically active species as an approach for theranostic systems

    Energy Technology Data Exchange (ETDEWEB)

    Arratia-Quijada, Jenny [Departamento de Ciencias de la Salud, Centro Universitario Tonalá, Universidad de Guadalajara, Av. Nuevo Periférico No. 555, C.P. 48525, Tonalá, Jalisco (Mexico); Sánchez Jiménez, Cecilia [Departamento de Química, Universidad de Guadalajara, Boulevard Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico); Gurinov, Andrey [Research Resources Center for Magnetic Resonance, St. Petersburg State University, Universitetskiy pr. 26, 198504 St. Petersburg (Russian Federation); NMR Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900 (Saudi Arabia); Pérez Centeno, Armando; Ceja Andrade, Israel [Departamento de Física, Universidad de Guadalajara, Boulevard Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico); Carbajal Arízaga, Gregorio Guadalupe, E-mail: gregoriocarbajal@yahoo.com.mx [Departamento de Química, Universidad de Guadalajara, Boulevard Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico)

    2016-01-15

    Graphical abstract: - Highlights: • LDH structure including dysprosium was prepared by co-precipitation. • LDH was capable to produce contrast in the T1 mode of MRI. • LDH were intercalated with folate, ibuprofen and gallate ions. - Abstract: A layered double hydroxide structure including dysprosium cations was prepared by co-precipitation. The nanoparticles showed a linear relationship with the reciprocal relaxation spin-lattice (T1) time of water protons which is reflected as contrast in aqueous suspensions analyzed by magnetic resonance imaging. The interlayer space of dysprosium containing LDH was successfully intercalated with folate, ibuprofen and gallate ions, which are key molecules for recognition of some cancer cells and treatment of diseases. The paramagnetic property of the dysprosium-containing LDH detected in this work beside the ability to transport drugs open up the opportunity to design theranostic materials in a single crystal phase with nanometric dimensions.

  17. Slow magnetic relaxation in a hydrogen-bonded 2D array of mononuclear dysprosium(III) oxamates.

    Science.gov (United States)

    Fortea-Pérez, Francisco R; Vallejo, Julia; Julve, Miguel; Lloret, Francesc; De Munno, Giovanni; Armentano, Donatella; Pardo, Emilio

    2013-05-01

    The reaction of N-(2,6-dimethylphenyl)oxamic acid with dysprosium(III) ions in a controlled basic media afforded the first example of a mononuclear lanthanide oxamate complex exhibiting a field-induced slow magnetic relaxation behavior typical of single-ion magnets (SIMs). The hydrogen-bond-mediated self-assembly of this new bifunctional dysprosium(III) SIM in the solid state provides a unique example of 2D hydrogen-bonded polymer with a herringbone net topology.

  18. 18 CFR 158.6 - Determination.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Determination. 158.6 Section 158.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT....6 Determination. If no formal hearing is had the matter in issue will be determined by the...

  19. 21 CFR 158.170 - Frozen peas.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen peas. 158.170 Section 158.170 Food and.... (a) Identity—(1) Product definition. Frozen peas is the food in “package” form as that term is... the words “frozen” or “quick frozen”. The name of the food shall include a declaration of...

  20. 14 CFR 158.53 - Collection compensation.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Collection compensation. 158.53 Section 158... Collection compensation. (a) As compensation for collecting, handling, and remitting the PFC revenue, the... a new compensation level based on an analysis of the data provided under paragraph (c)(1) of...

  1. 49 CFR 173.158 - Nitric acid.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Nitric acid. 173.158 Section 173.158... Nitric acid. (a) Nitric acid exceeding 40 percent concentration may not be packaged with any other material. (b) Nitric acid in any concentration which does not contain sulfuric acid or hydrochloric acid as...

  2. 21 CFR 225.158 - Laboratory assays.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory assays. 225.158 Section 225.158 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... Laboratory assays. Where the results of laboratory assays of drug components, including assays by State...

  3. Dysprosium-Catalyzed Growth of Single-Walled Carbon Nanotube Arrays on Substrates

    Directory of Open Access Journals (Sweden)

    Qian Yong

    2009-01-01

    Full Text Available Abstract In this letter, we report that dysprosium is an effective catalyst for single-walled carbon nanotubes (SWNTs growth via a chemical vapor deposition (CVD process for the first time. Horizontally superlong well-oriented SWNT arrays on SiO2/Si wafer can be fabricated by EtOH-CVD under suitable conditions. The structure and properties are characterized by scanning electron microscopy, transition electron microscopy, Raman spectroscopy and atomic force microscopy. The results show that the SWNTs from dysprosium have better structural uniformity and better conductivity with fewer defects. This rare earth metal provides not only an alternative catalyst for SWNTs growth, but also a possible method to generate high percentage of superlong semiconducting SWNT arrays for various applications of nanoelectronic device.

  4. Direct Search for keV Sterile Neutrino Dark Matter with a Stable Dysprosium Target

    CERN Document Server

    Lasserre, T; Cribier, M; Merle, A; Mertens, S; Vivier, M

    2016-01-01

    We investigate a new method to search for keV-scale sterile neutrinos that could account for Dark Matter. Neutrinos trapped in our galaxy could be captured on stable $^{163}$Dy if their mass is greater than 2.83~keV. Two experimental realizations are studied, an integral counting of $^{163}$Ho atoms in dysprosium-rich ores and a real-time measurement of the emerging electron spectrum in a dysprosium-based detector. The capture rates are compared to the solar neutrino and radioactive backgrounds. An integral counting experiment using several kilograms of $^{163}$Dy could reach a sensitivity for the sterile-to-active mixing angle $\\sin^2\\theta_{e4}$ of $10^{-5}$ significantly exceeding current laboratory limits. Mixing angles as low as $\\sin^2\\theta_{e4} \\sim 10^{-7}$ / $\\rm m_{^{163}\\rm Dy}\\rm{(ton)}$ could possibly be explored with a real-time experiment.

  5. Preparation of Dysprosium Ferrite/Polyacrylamide Magnetic Composite Microsphere and Its Characterization

    Institute of Scientific and Technical Information of China (English)

    Hidehiro Kumazawa; Wang Zhifeng; Zhou Lanxiang; Zhang Hong; Li Yourong; Zhang Ming

    2005-01-01

    Using the technique of microemulsion polymerization with nano-reactor, dysprosium ferrite/polyacrylamide magnetic composite microsphere was prepared by one-step method in a single inverse microemulsion. The structure, average particle size, morphology of composite microsphere were characterized by FTIR, XRD, TEM and TGA. The magnetic responsibility of composite microsphere was also investigated. The results indicate that the magnetic composite microsphere possess high magnetic responsibility and suspension stability.

  6. {Delta}I = 2 energy staggering in normal deformed dysprosium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Riley, M.A.; Brown, T.B.; Archer, D.E. [Florida State Univ., Tallahassee, FL (United States)] [and others

    1996-12-31

    Very high spin states (I{ge}50{Dirac_h}) have been observed in {sup 155,156,157}Dy. The long regular band sequences, free from sharp backbending effects, observed in these dysprosium nuclei offer the possibility of investigating the occurence of any {Delta}I = 2 staggering in normal deformed nuclei. Employing the same analysis techniques as used in superdeformed nuclei, certain bands do indeed demonstrate an apparent staggering and this is discussed.

  7. Poly[[[μ3-N′-(carboxymethylethylenediamine-N,N,N′-triacetato]dysprosium(III] trihydrate

    Directory of Open Access Journals (Sweden)

    Xiaomei Zhuang

    2010-11-01

    Full Text Available In the title coordination polymer, {[Dy(C10H13N2O8]·3H2O}n, the dysprosium(III ion is coordinated by two N atoms and six O atoms from three different (carboxymethylethylenediaminetriacetate ligands in a distorted square-antiprismatic geometry. The ligands connect the metal atoms, forming layers parallel to the ab plane. O—H...O hydrogen bonds further assemble adjacent layers into a three-dimensional supramolecular network.

  8. Making two dysprosium atoms rotate - Einstein-de Haas effect revisited

    OpenAIRE

    Górecki, Wojciech; Rzążewski, Kazimierz

    2016-01-01

    We present a numerical study of the behaviour of two magnetic dipolar atoms trapped in a harmonic potential and exhibiting the standard Einstein-de Haas effect while subject to a time dependent homogeneous magnetic field. Using a simplified description of the short range interaction and the full expression for the dipole-dipole forces we show, that under experimentally realisable conditions two dysprosium atoms may be pumped to a high ($l>20$) value of the relative orbital angular momentum.

  9. Phosphor Dysprosium-Doped Layered Double Hydroxides Exchanged with Different Organic Functional Groups

    Directory of Open Access Journals (Sweden)

    David Ricardo Martínez Vargas

    2013-01-01

    Full Text Available The layers of a Zn/Al layered double hydroxide (LDH were doped with Dy3+ cations. Among some compositions, the Zn2+ : Al3+ : Dy3+ molar ratio equal to 30 : 9 : 1 presented a single crystalline phase. Organic anions with carboxylic, amino, sulfate, or phosphate functional groups were intercalated as single layers between LDH layers as confirmed by X-ray diffraction and infrared spectroscopy. Photoluminescence spectra of the nitrate intercalated LDH showed a wide emission band with strong intensity in the yellow region (around 574 nm, originated due to symmetry distortion of the octahedral coordination in dysprosium centers. Moreover, a broad red band emission was also detected apparently due to the presence of zinc oxide. The distorted symmetry of the dysprosium coordination environment, also confirmed by X-ray photoelectron spectroscopy analysis, was modified after the intercalation with phenyl phosphonate (PP, aspartate (Asp, adipate (Adip, and serinate (Ser anions; the emission as measured from PL spectra of these LDH was more intense in the blue region (ca. 486 nm, thus indicating an increase in symmetry of dysprosium octahedrons. The red emission band from zinc oxide kept the same intensity after intercalation of dodecyl sulfate (DDS. An additional emission of unknown origin at λ = 767 nm was present in all LDHs.

  10. Stream Habitat Reach Summary - NCWAP [ds158

    Data.gov (United States)

    California Department of Resources — The Stream Habitat - NCWAP - Reach Summary [ds158] shapefile contains in-stream habitat survey data summarized to the stream reach level. It is a derivative of the...

  11. Systematic study on surface and magnetostructural changes in Mn-substituted dysprosium ferrite by hydrothermal method

    Energy Technology Data Exchange (ETDEWEB)

    Rekha, G. [Department of Physics, College of Engineering Guindy, Anna University, Sardar Patel Road, Chennai 600025 (India); Tholkappiyan, R. [Department of Physics, College of Engineering Guindy, Anna University, Sardar Patel Road, Chennai 600025 (India); Department of Physics, College of Science, UAE University, Al-Ain 15551 (United Arab Emirates); Vishista, K., E-mail: raovishista@gmail.com [Department of Physics, College of Engineering Guindy, Anna University, Sardar Patel Road, Chennai 600025 (India); Hamed, Fathalla [Department of Physics, College of Science, UAE University, Al-Ain 15551 (United Arab Emirates)

    2016-11-01

    Highlights: • Garnet type Dy{sub 3}Fe{sub 5-x}Mn{sub x}O{sub 12} (x = 0–0.06) nanoparticles of 88.4–86.8 nm were synthesized by hydrothermal method. • The Dy, Mn, Fe and O elements in the ferrites were confirmed from XPS. • The multiple oxidation states of Fe and Mn ions, bonding energy and cationic distributions of the samples were examined by XPS. • The magnetic property shows ferromagnetic behavior from VSM technique. • The results from these studies are correlated with respect to Mn dopant. - Abstract: Dysprosium iron garnets are of scientific importance because of the wide range of magnetic properties that can be obtained in substituting dysprosium by a rare earth metal. In the present work, the effect of Mn substitution on magnetostructural changes in dysprosium ferrite nanoparticles is studied. Highly crystalline pure and Mn doped dysprosium ferrite nanoparticles were synthesized by hydrothermal method. The samples were calcined at 1100 °C for 2 h in air atmosphere which is followed by characterization using XRD, FT-IR analysis, SEM, XPS and VSM. The average crystallite size of synthesized samples were calculated by X-ray diffraction falls in the range of 88.4–86.8 nm and was found to be in cubic garnet structure. For further investigation of the structure and corresponding changes in the tetrahedral and octahedral stretching vibrational bonds, FT-IR was used. The synthesized samples consist of multiple oxidation (Fe{sup 3+} and Fe{sup 2+}) states for Fe ions and (Mn{sup 3+} and Mn{sup 2+}) Mn ions analyzed in three ways of Fe 2p and Mn 2p spectra from the XPS analysis. With respect to Mn dopant in Dy{sub 3}Fe{sub 5}O{sub 12}, the cationic distributions of elements were discussed from high resolution XPS spectra by peak position and shift, area, width. To find out the porous/void surface morphology of the sample, scanning electron microscopy was used. From XPS analysis, the presence of elements (Dy, Mn, Fe and O) and their composition in the

  12. Synthesis, structural characterization and in vitro testing of dysprosium containing silica particles as potential MRI contrast enhancing agents

    Energy Technology Data Exchange (ETDEWEB)

    Chiriac, L.B.; Trandafir, D.L. [Faculty of Physics & National Magnetic Resonance Center, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Interdisciplinary Research Institute on Bio-Nano-Sciences & Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Turcu, R.V.F. [Faculty of Physics & National Magnetic Resonance Center, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Todea, M. [Interdisciplinary Research Institute on Bio-Nano-Sciences & Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Simon, S., E-mail: simons@phys.ubbcluj.ro [Faculty of Physics & National Magnetic Resonance Center, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania); Interdisciplinary Research Institute on Bio-Nano-Sciences & Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca, RO-400084 (Romania)

    2016-11-01

    Highlights: • Dysprosium containing silica microparticles obtained by freeze and spray drying. • Higher structural units interconnection achieved in freeze vs. spray dried samples. • Dy occurance on the outermost layer of the microparticles evidenced by XPS. • Enhanced MRI contrast observed for freeze dried samples with 5% mol Dy{sub 2}O{sub 3}. - Abstract: The work is focused on synthesis and structural characterization of novel dysprosium-doped silica particles which could be considered as MRI contrast agents. Sol-gel derived silica rich particles obtained via freeze-drying and spray-drying processing methods were structurally characterized by XRD, {sup 29}Si MAS-NMR and XPS methods. The occurrence of dysprosium on the outermost layer of dysprosium containing silica particles was investigated by XPS analysis. The MRI contrast agent characteristics have been tested using RARE-T{sub 1} and RARE-T{sub 2} protocols. The contrast of MRI images delivered by the investigated samples was correlated with their local structure. Dysprosium disposal on microparticles with surface structure characterised by decreased connectivity of the silicate network units favours dark T{sub 2}-weighted MRI contrast properties.

  13. Dicty_cDB: CHS158 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS158 (Link to dictyBase) - - - Contig-U16313-1 CHS158P (Link to Original site) CHS1...58F 647 CHS158Z 746 CHS158P 1373 - - Show CHS158 Library CH (Link to library) Clone ID CHS1...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHS1-C/CHS158Q.Seq.d/ Representative seq. ID CHS1...58P (Link to Original site) Representative DNA sequence >CHS158 (CHS158Q) /CSM/CH/CHS1-C/CHS1...n*fqfniti*tlsll*nliink kttapfk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHS158 (CHS1

  14. Dicty_cDB: SLB158 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB158 (Link to dictyBase) - - - Contig-U16455-1 SLB158Z (Link... to Original site) - - SLB158Z 721 - - - - Show SLB158 Library SL (Link to library) Clone ID SLB158 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB1-C/SLB158Q.Seq.d/ Representative seq. ID SLB15...8Z (Link to Original site) Representative DNA sequence >SLB158 (SLB158Q) /CSM/SL/SLB1-C/SLB158Q.Seq.d/ XXXXX... SLE193 (SLE193Q) /CSM/SL/SLE1-D/SLE193Q.Seq.d/ 1407 0.0 SLB795 (SLB795Q) /CSM/SL/SLB7-D/SLB795Q.Seq.d/ 1407 0.0 SLB249 (SLB

  15. Influence of exchange splitting on optical properties in gadolinium and dysprosium single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Knyazev, Yu.V.; Bolotin, G.A. (AN SSSR, Sverdlovsk. Inst. Fiziki Metallov)

    1984-12-01

    The temperature dependences of optical conductivity in gadolinium and dysprosium single crystals at the light wave vector polarization along a hexagonal axis and in the basis plane are considered. A substantial anisotropy of interzonal absorption has been found. The sample transition into magnetically ordered state is shown to be accompanied by the emergence of resonance absorption peaks in the near infrared spectral region. The manifestation of these peculiarities is associated with quantum electron transitions between the s-, d-f- interaction-split energy bands near the Fermi level. Main peculiarities of the experimental spectrum of gadolinium optical conductivity found their reflection in theoretically calculated dispersion dependence.

  16. Therapeutic application of dysprosium-165-FHMA in the treatment of rheumatoid knee effusions

    Energy Technology Data Exchange (ETDEWEB)

    English, R.J.; Zalutsky, M.; Venkatesan, P.; Sledge, C.B.

    1986-03-01

    Radiation synovectomy utilizing a variety of radionuclides has proven to be an effective technique in the treatment of rheumatoid arthritis. The recent introduction of the short-lived radionuclide, Dysprosium-165 (/sup 165/Dy), as a replacement for the longer-lived radiocolloids has reduced nontarget dosimetry caused by leakage of the agent from the articular cavity. A review of the methods and status of radiation synovectomy, and the application of /sup 165/Dy-ferric hydroxide macroaggregates (FHMA) as an alternative therapeutic agent is described.

  17. Properties of dysprosium-doped gallium lanthanum sulfide fiber amplifiers operating at 1.3 microm.

    Science.gov (United States)

    Samson, B N; Schweizer, T; Hewak, D W; Laming, R I

    1997-05-15

    In light of recent progress in the fabrication of gallium lanthanum sulfide (GaLaS) fibers, we have modeled the performance of dysprosium-doped GaLaS fiber amplifiers operating at 1.3 microm . Based on experimental data, we find that the incorporation of a codopant (terbium) in the fiber core significantly shortens the optimum amplifier length from >30 m to approximately 3 m . Such a device may be practical, given the fiber losses currently achieved in GaLaS fibers.

  18. 40 CFR 158.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES General Provisions § 158.3 Definitions. All terms defined in sec. 2 of the Federal Insecticide, Fungicide, and Rodenticide Act apply to this part and are used with the meaning given in the...

  19. Reference: 158 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 158 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15659098i Dieterle Monika et al. 2005 Fe...lin 3A. 3 386-99 15659098 2005 Feb The Plant journal Cognat Valerie|Dieterle Monika|Genschik Pascal|Kretsch

  20. 40 CFR 98.158 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING HCFC-22 Production and HFC-23 Destruction § 98.158 Definitions. All terms used in... Service Emission factor(kg/hr/source) ≥10,000 ppmv Gas 0.0782 0.000131 Valves...

  1. 42 CFR 417.158 - Payroll deductions.

    Science.gov (United States)

    2010-10-01

    ....158 Payroll deductions. Each employing entity that provides payroll deductions as a means of paying employees' contributions for health benefits or provides a health benefits plan that does not require an employee contribution must, with the consent of an employee who selects the HMO option, arrange for the...

  2. Effect of dysprosium on the kinetics and structural transformations during the decomposition of the supersaturated solid solution in magnesium-samarium alloys

    Science.gov (United States)

    Rokhlin, L. L.; Luk'yanova, E. A.; Tabachkova, N. Yu.; Dobatkina, T. V.; Tarytina, I. E.; Korol'kova, I. G.

    2017-03-01

    The effect of dysprosium added in the amounts such that it does not form an individual phase in equilibrium with solid magnesium on the decomposition of the supersaturated magnesium solid solution in Mg-Sm alloys is studied. The presence of dysprosium in Mg-Sm alloys is found to retard the decomposition of the supersaturated magnesium solid solution and to increase the hardening effect upon aging. When these alloys are aged, dysprosium is partly retained in the magnesium solid solution and partly enters into the compositions of the phases that form during the decomposition of the solid solution and are characteristic of Mg-Sm alloys.

  3. Cyclic single-molecule magnets: from the odd-numbered heptanuclear to a dimer of heptanuclear dysprosium clusters.

    Science.gov (United States)

    Tian, Haiquan; Bao, Song-Song; Zheng, Li-Min

    2016-02-01

    A heptanuclear and a dimer of heptanuclear dysprosium clusters (Dy7 and Dy14) have been successfully synthesized by ingenious coalescence of the single and double pyrazinyl hydrazone as well as phosphonate ligands. The complexes feature the largest odd-numbered cyclic lanthanide clusters reported thus far. Both exhibit single molecule magnet behaviors at low temperature.

  4. A comparison of the effects of symmetry and magnetoanisotropy on paramagnetic relaxation in related dysprosium single ion magnets.

    Science.gov (United States)

    Williams, Ursula J; Mahoney, Brian D; DeGregorio, Patrick T; Carroll, Patrick J; Nakamaru-Ogiso, Eiko; Kikkawa, James M; Schelter, Eric J

    2012-06-07

    Dysprosium complexes of the tmtaa(2-) ligand were synthesized and characterized by X-band EPR and magnetism studies. Both complexes demonstrate magnetoanisotropy and slow paramagnetic relaxation. Comparison of these compounds with the seminal phthalocyanine complex [Dy(Pc)(2)](-) shows the azaannulide complexes are more susceptible to relaxation through non-thermal pathways.

  5. Dual responsive dysprosium-doped hydroxyapatite particles and toxicity reduction after functionalization with folic and glucuronic acids

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez Lafarga, Ana Karen; Pacheco Moisés, Fermín P. [Departamento de Química, Universidad de Guadalajara, Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico); Gurinov, Andrey [Research Resources Center for Magnetic Resonance, Saint Petersburg State University, Universitetskij pr. 26, 198504 St. Petersburg (Russian Federation); Ortiz, Genaro Gabriel [Laboratorio Desarrollo-Envejecimiento, Enfermedades Neurodegenerativas, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano de Seguro Social (IMSS), Guadalajara, Jalisco (Mexico); Carbajal Arízaga, Gregorio Guadalupe, E-mail: gregoriocarbajal@yahoo.com.mx [Departamento de Química, Universidad de Guadalajara, Marcelino García Barragán 1421, C.P. 44430, Guadalajara, Jalisco (Mexico)

    2015-03-01

    The development of probes for biomedical applications demands materials with low toxicity levels besides fluorescence or magnetic properties to be detected by confocal microscopes or MRI resonators. Several drug delivery systems or other biomedical materials prepared with hydroxyapatite have been proposed, however, toxicity effects might arise when the size of particles is nanometric. In this study, hydroxyapatite functionalized with glucuronic or folic acids presented lower oxidative stress, measured from lipoperoxides and nitric oxide indicators in rats than pure hydroxyapatite. In separated experiments, hydroxyapatite was doped with dysprosium cations by coprecipitation producing a single crystal phase with fluorescent properties easily visualized by confocal microscopy when excited at 488 nm. These particles also presented the ability to modify the proton relaxation time in T1 maps collected by magnetic resonance imaging. These modified hydroxyapatite nanoparticles could be candidates to design bimodal probes with low toxicity. - Highlights: • Hydroxyapatite functionalized with glucuronic acid reduced oxidative stress in rats. • Functionalization with folic acid reduced oxidative stress in rats. • Dysprosium doping does not affect the crystalline structure of hydroxyapatite. • Dysprosium doped particles are visible in fluorescent microscope. • Dysprosium doped particles act as MRI contrast agents.

  6. Tuning Slow Magnetic Relaxation in a Two-Dimensional Dysprosium Layer Compound through Guest Molecules.

    Science.gov (United States)

    Chen, Qi; Li, Jian; Meng, Yin-Shan; Sun, Hao-Ling; Zhang, Yi-Quan; Sun, Jun-Liang; Gao, Song

    2016-08-15

    A novel two-dimensional dysprosium(III) complex, [Dy(L)(CH3COO)]·0.5DMF·H2O·2CH3OH (1), has been successfully synthesized from a new pyridine-N-oxide (PNO)-containing ligand, namely, N'-(2-hydroxy-3-methoxybenzylidene)pyridine-N-oxidecarbohydrazide (H2L). Single-crystal X-ray diffraction studies reveal that complex 1 is composed of a dinuclear dysprosium subunit, which is further extended by the PNO part of the ligand to form a two-dimensional layer. Magnetic studies indicate that complex 1 shows well-defined temperature- and frequency-dependent signals under a zero direct-current (dc) field, typical of slow magnetic relaxation with an effective energy barrier Ueff of 33.6 K under a zero dc field. Interestingly, powder X-ray diffraction and thermogravimetric analysis reveal that compound 1 undergoes a reversible phase transition that is induced by the desorption and absorption of methanol and water molecules. Moreover, the desolvated sample [Dy(L)(CH3COO)]·0.5DMF (1a) also exhibits slow magnetic relaxation but with a higher anisotropic barrier of 42.0 K, indicating the tuning effect of solvent molecules on slow magnetic relaxation.

  7. Dosimetric properties of dysprosium doped calcium magnesium borate glass subjected to Co-60 gamma ray

    Energy Technology Data Exchange (ETDEWEB)

    Omar, R. S., E-mail: ratnasuffhiyanni@gmail.com; Wagiran, H., E-mail: husin@utm.my; Saeed, M. A. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru (Malaysia)

    2016-01-22

    Thermoluminescence (TL) dosimetric properties of dysprosium doped calcium magnesium borate (CMB:Dy) glass are presented. This study is deemed to understand the application of calcium as the modifier in magnesium borate glass with the presence of dysprosium as the activator to be performed as TL dosimeter (TLD). The study provides fundamental knowledge of a glass system that may lead to perform new TL glass dosimetry application in future research. Calcium magnesium borate glass systems of (70-y) B{sub 2}O{sub 3} − 20 CaO – 10 MgO-(y) Dy{sub 2}O{sub 3} with 0.05  mol % ≤ y ≤ 0.7  mol % of dyprosium were prepared by melt-quenching technique. The amorphous structure and TL properties of the prepared samples were determined using powder X-ray diffraction (XRD) and TL reader; model Harshaw 4500 respectively. The samples were irradiated to Co-60 gamma source at a dose of 50 Gy. Dosimetric properties such as annealing procedure, time temperature profile (TTP) setting, optimization of Dy{sub 2}O{sub 3} concentration of 0.5 mol % were determined for thermoluminescence dosimeter (TLD) reader used.

  8. Bistatic radar observations of 2011 UW158

    Science.gov (United States)

    Bondarenko, Yuri; Ipatov, Alexander; Medvedev, Yuri; Mishina, Nadezda; Marshalov, Dmitry; Benner, Lance A. M.

    2016-10-01

    We report results of intercontinental bistatic radar observations of near-Earth Asteroid 2011 UW158 during its close approach to the Earth in July 2015. High power continuous wave signal at a fixed 8.4 GHz frequency was transmitted to the asteroid from the 70 m antenna of the Goldstone Observatory (DSS-14) and then the echo reflected back from the target was received by the 32 m radio telescopes of Quasar VLBI network in Zelenchukskaya and Badary observatories. Analysis of the echo power spectra allowed us to estimate the size and spin period, which agrees with the photometric observations as well as obtain some information about asteroid's shape and near-surface roughness. We also reported 18 Doppler estimates and computed the heliocentric orbit of 2011 UW158.

  9. 18 CFR 158.7 - Assignment for oral hearing.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Assignment for oral hearing. 158.7 Section 158.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Proposed Remedies § 158.7 Assignment for oral hearing. In case consent to the shortened procedure is not...

  10. 18 CFR 158.12 - Qualifications of accountants.

    Science.gov (United States)

    2010-04-01

    ... accountants. 158.12 Section 158.12 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Proposed Remedies § 158.12 Qualifications of accountants. The Commission will recognize only independent certified public accountants, or independent licensed public accountants who were licensed on or...

  11. 12 CFR 308.158 - Filing papers and effective date.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Filing papers and effective date. 308.158 Section 308.158 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE... Section 19 of the FDIA § 308.158 Filing papers and effective date. (a) Filing with the regional...

  12. 40 CFR 158.2010 - Biochemical pesticides data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides data...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2010 Biochemical pesticides... required to support registration of biochemical pesticides. Sections 158.2080 through 158.2084 identify...

  13. 40 CFR 158.1410 - Residue chemistry data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Residue chemistry data requirements table. 158.1410 Section 158.1410 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Residue Chemistry § 158.1410 Residue chemistry data...

  14. 19 CFR 158.21a - Time period.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Time period. 158.21a Section 158.21a Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... While in Customs Custody § 158.21a Time period. An abatement or refund of duties shall be made in the...

  15. 7 CFR 3550.158 - Active military duty.

    Science.gov (United States)

    2010-01-01

    ... include participation in a military reserve or the National Guard unless the borrower is called to active... 7 Agriculture 15 2010-01-01 2010-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military...

  16. 27 CFR 25.158 - Tax computation for bottled beer.

    Science.gov (United States)

    2010-04-01

    ... bottled beer. 25.158 Section 25.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.158 Tax computation for bottled beer. Barrel equivalents for various case sizes are as follows: (a) For U.S....

  17. Luminescent properties of dysprosium(Ⅲ) ions in LaAlO3 nanocrystallites

    Institute of Scientific and Technical Information of China (English)

    K. Lema(n)ski; P.J. Dere(n)

    2011-01-01

    The absorption and emission spectra as well as decay time profile of Dy3+ ions in LaAlO3 nanocrystals were analyzed.The crystal structure of LaAlO3 was confirmed from XRD measurement.The emission peaks from blue to red came from main emitting level of dysprosium 4F9/2 to the ground and other excited levels of Dy3+ ions.Cross relaxation process led to non-radiative quenching of luminescence,so that the lifetime of the 4F9/2 energy level ions decreased with increasing amount of doped Dy3+ ions.The cross relaxation transfer rates were experimentally determined as a function of Dy3+ concentration.

  18. Magnetic ordering temperatures in rare earth metal dysprosium under ultrahigh pressures

    Science.gov (United States)

    Samudrala, Gopi K.; Tsoi, Georgiy M.; Weir, Samuel T.; Vohra, Yogesh K.

    2014-04-01

    Magnetic ordering temperatures in heavy rare earth metal dysprosium (Dy) have been studied using an ultrasensitive electrical transport measurement technique in a designer diamond anvil cell to a pressure of 69 GPa and a temperature of 10 K. Previous studies using magnetic susceptibility measurements at high pressures were able to track magnetic ordering temperature only till 7 GPa in the hexagonal close packed (hcp) phase of Dy. Our studies indicate that the magnetic ordering temperature shows an abrupt drop of 80 K at the hcp-Sm phase transition followed by a gradual decrease that continues till 17 GPa. This is followed by a rapid increase in the magnetic ordering temperatures in the double hcp phase and finally leveling off in the distorted face centered cubic phase of Dy. Our studies reaffirm that 4f-shell remains localized in Dy and there is no loss of magnetic moment or 4f-shell delocalization for pressures up to 69 GPa.

  19. Electrochemical behaviour of dysprosium in the eutectic LiCl-KCl at W and Al electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Castrillejo, Y. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain)]. E-mail: ycastril@qa.uva.es; Bermejo, M.R. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Barrado, A.I. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Pardo, R. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Barrado, E. [Dpto de Quimica Analitica, Facultad de Ciencias, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid (Spain); Martinez, A.M. [Department of Materials Technology, Sem Saelands vei 6, 7491 Trondheim (Norway)

    2005-03-15

    The electrochemical behaviour of DyCl{sub 3} was studied in the eutectic LiCl-KCl at different temperatures. The cathodic reaction can be written:Dy(III)+3e-bar Dy(0)which can be divided in two very close cathodic steps:Dy(III)+1e-bar Dy(II)andDy(II)+2e-bar Dy(0)Transient electrochemical techniques, such as cyclic voltammetry, chronopotentiometry, and chronoamperometry were used in order to study the reaction mechanism and the transport parameters of electroactive species at a tungsten electrode. The results showed that in the eutectic LiCl-KCl, electrocrystallization of dysprosium seems to be the controlling electrochemical step. Chronoamperometric studies indicated instantaneous nucleation of dysprosium with three dimensional growth of the nuclei whatever the applied overpotential.Mass transport towards the electrode is a simple diffusion process, and the diffusion coefficient of the electroactive species, i.e. Dy(III), has been calculated. The validity of the Arrhenius law was also verified by plotting the variation of the logarithm of the diffusion coefficient versus 1/T.In addition, the electrode reactions of the LiCl-KCl-DyCl{sub 3} solutions at an Al wire were also investigated by cyclic voltammetry and open circuit chronopotentiometry. The redox potential of the Dy(III)/Dy couple at the Al electrode was observed at more positive potentials values than those at the inert electrode. This potential shift was thermodynamically analyzed by a lowering of activity of Dy in the metal phase due to the formation of intermetallic compounds.

  20. Dicty_cDB: SSI158 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSI158 (Link to dictyBase) - - - Contig-U05414-1 SSI158Z (Link to Original si...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSI1-C/SSI158Q.Seq.d/ Representative seq. ID SSI158Z (Link to Original si...keletal 8.0 %: mitochondrial 4.0 %: vacuolar 4.0 %: vesicles of secretory system >> prediction for SSI...te) - - SSI158Z 644 - - - - Show SSI158 Library SS (Link to library) Clone ID SSI158 (Link to... dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U05414-1 Original site URL http://dict

  1. Structural, optical, thermal, mechanical and dielectric studies of Sulfamic acid single crystals: An influence of dysprosium (Dy3+) doping

    Science.gov (United States)

    Singh, Budhendra; Shkir, Mohd.; AlFaify, S.; Kaushal, Ajay; Nasani, Narendar; Bdikin, Igor; Shoukry, H.; Yahia, I. S.; Algarni, H.

    2016-09-01

    Sulfamic acid is a potential material that exhibits excellent optical properties. A good quality, pure and dysprosium (Dy3+) doped (2.5 and 5 mol %) Sulfamic acid (SA) single crystals were grown successfully by slow cooling method. Structural study revealed a slight change in its lattice parameters and volume, suggesting the successful incorporation of Dy3+ in crystal system. The existence of dysprosium in the system was also confirmed. Presence of various vibrational modes was confirmed. Optical transparency was found to have a significant effect with variation in the doping concentration. Furthermore, a marked enhancement in its mechanical parameters with doping was also identified by nanoindentation technique. Etching study was also performed on the grown crystals to study the etch-pit formation and growth mechanism. Effect of doping on the thermal stability was analysed. All the results were compared and discussed in detail to get insight of the effect of doping concentration on Sulfamic acid crystal.

  2. Optical trapping of ultracold dysprosium atoms: transition probabilities, dynamic dipole polarizabilities and van der Waals $C_6$ coefficients

    CERN Document Server

    Li, Hui; Dulieu, Olivier; Nascimbene, Sylvain; Lepers, Maxence

    2016-01-01

    The efficiency of optical trapping of ultracold atoms depend on the atomic dynamic dipole polarizability governing the atom-field interaction. In this article, we have calculated the real and imaginary parts of the dynamic dipole polarizability of dysprosium in the ground and first excited level. Due to the high electronic angular momentum of those two states, the polarizabilities possess scalar, vector and tensor contributions that we have computed, on a wide range of trapping wavelengths, using the sum-over-state formula. Using the same formalism, we have also calculated the $C_6$ coefficients characterizing the van der Waals interaction between two dysprosium atoms in the two lowest levels. We have computed the energies of excited states and the transition probabilities appearing in the sums, using a combination of \\textit{ab initio} and least-square-fitting techniques provided by the Cowan codes and extended in our group. Regarding the real part of the polarizability, for field frequencies far from atomic...

  3. Mixed (phthalocyaninato)(Schiff-base) di-dysprosium sandwich complexes. Effect of magnetic coupling on the SMM behavior.

    Science.gov (United States)

    Wang, Hailong; Liu, Chenxi; Liu, Tao; Zeng, Suyuan; Cao, Wei; Ma, Qi; Duan, Chunying; Dou, Jianmin; Jiang, Jianzhuang

    2013-11-21

    Reaction between Schiff-base ligand and half-sandwich complex M(Pc)(acac) led to the isolation of new sandwich-type mixed (phthalocyaninato)(Schiff-base) di-lanthanide compounds M2(Pc)2(L)H2O (M = Dy, Gd) (1, 2) [H2Pc = metal free phthalocyanine, Hacac = acetylacetone, H2L = N,N'-bis(3-methyloxysalicylidene)benzene-1,2-diamine] with the triple-decker molecular structure clearly revealed by single crystal X-ray diffraction analysis. For the comparative studies, sandwich triple-decker analogues with pure Schiff-base ligand M2(L)3H2O (M = Dy, Gd) (3, 4) were also prepared. Dynamic magnetic measurement result reveals the single-molecule magnet (SMM) nature of the di-dysprosium derivative 1, while the static magnetic investigation over both pure and the diamagnetic diluted samples of this compound discloses the interionic ferromagnetic coupling between the two dysprosium ions, which in turn effectively suppresses the QTM and enhances the energy barrier of this SMM. Nevertheless, comparative studies over the static magnetic properties of the di-dysprosium triple-decker complexes 1 and 3 indicate the stronger magnetic coupling between the two lanthanide ions in mixed (phthalocyaninato)(Schiff-base) species than in the pure Schiff-base triple-decker analogue, suggesting the special coordination sphere around the dysprosium ions in the former compound over the latter one on the more intense inter-ionic ferromagnetic coupling. As a very small step towards understanding the structure-property relationship, the present result will be surely helpful for the design and synthesis of the multinuclear lanthanide-based SMMs with good properties.

  4. Evaluating United States and world consumption of neodymium, dysprosium, terbium, and praseodymium in final products

    Science.gov (United States)

    Hart, Matthew

    This paper develops scenarios of future rare-earth-magnet metal (neodymium, dysprosium, terbium, and praseodymium) consumption in the permanent magnets used in wind turbines and hybrid electric vehicles. The scenarios start with naive base-case scenarios for growth in wind-turbine and hybrid-electric-vehicle sales over the period 2011 to 2020, using historical data for each good. These naive scenarios assume that future growth follows time trends in historical data and does not depend on any exogenous variable. Specifically, growth of each technological market follows historical time trends, and the amount of rare earths used per unit of technology remains fixed. The chosen reference year is 2010. Implied consumptions of the rare earth magnet metals are calculated from these scenarios. Assumptions are made for the material composition of permanent magnets, the market share of permanent-magnet wind turbines and vehicles, and magnet weight per unit of technology. Different scenarios estimate how changes in factors like the material composition of magnets, growth of the economy, and the price of a substitute could affect future consumption. Each scenario presents a different method for reducing rare earth consumption and could be interpreted as potential policy choices. In 2010, the consumption (metric tons, rare-earth-oxide equivalent) of each rare-earth-magnet metal was as follows. Total neodymium consumption in the world for both technologies was 995 tons; dysprosium consumption was 133 tons; terbium consumption was 50 tons; praseodymium consumption was zero tons. The base scenario for wind turbines shows there could be strong, exponential growth in the global wind turbine market. New U.S. sales of hybrid vehicles would decline (in line with the current economic recession) while non-U.S. sales increase through 2020. There would be an overall increase in the total amount of magnetic rare earths consumed in the world. Total consumption of each rare earth in the short

  5. 20 CFR 655.158 - Duration of positive recruitment.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of positive recruitment. 655.158 Section 655.158 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY... recruitment. Except as otherwise noted, the obligation to engage in positive recruitment described in §§ 655...

  6. 14 CFR 135.158 - Pitot heat indication systems.

    Science.gov (United States)

    2010-01-01

    ... instrument pitot heating system unless the airplane is also equipped with an operable pitot heat indication... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pitot heat indication systems. 135.158... Equipment § 135.158 Pitot heat indication systems. (a) Except as provided in paragraph (b) of this...

  7. 19 CFR 158.30 - Review of port director's decision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Review of port director's decision. 158.30 Section 158.30 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) RELIEF FROM DUTIES ON MERCHANDISE LOST, DAMAGED, ABANDONED, OR...

  8. 19 CFR 158.29 - Decision by port director.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Decision by port director. 158.29 Section 158.29 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) RELIEF FROM DUTIES ON MERCHANDISE LOST, DAMAGED, ABANDONED, OR EXPORTED Casualty,...

  9. 33 CFR 158.240 - Ship repair yards.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Ship repair yards. 158.240... Facilities: Oily Mixtures § 158.240 Ship repair yards. The reception facility that services oceangoing ships using a ship repair yard must have a capacity for receiving— (a) An amount of ballast from bunker...

  10. 40 CFR 158.2110 - Microbial pesticides data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides data requirements...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2110 Microbial pesticides data requirements. (a) For all microbial pesticides. (1) The following § 158.2120 through §...

  11. 40 CFR 158.100 - Pesticide use patterns.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Pesticide use patterns. 158.100... DATA REQUIREMENTS FOR PESTICIDES How To Use Data Tables § 158.100 Pesticide use patterns. (a) General use patterns. There are six broad use categories used in the data tables. The six broad categories...

  12. 40 CFR 158.1300 - Environmental fate data requirements table.

    Science.gov (United States)

    2010-07-01

    ... transformation products. 7. Environmental chemistry methods used to generate data associated with this study must... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Environmental fate data requirements table. 158.1300 Section 158.1300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

  13. 33 CFR 158.520 - Following the instruction manual.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Following the instruction manual... Operations § 158.520 Following the instruction manual. The person in charge shall ensure that the instruction manual under § 158.330(b) is followed during the transfer of any NLS....

  14. 18 CFR 158.4 - Form and style.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Form and style. 158.4 Section 158.4 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT....4 Form and style. Each memoranda must be complete in itself. All pertinent data should be set...

  15. Luminescence features of dysprosium and phosphorus oxide co-doped lithium magnesium borate glass

    Science.gov (United States)

    Hashim, S.; Mhareb, M. H. A.; Ghoshal, S. K.; Alajerami, Y. S. M.; Saripan, M. I.; Bradley, D. A.

    2017-08-01

    Lithium magnesium borate (LMB) glass system co-doped with the oxides of dysprosium (Dy2O3) and phosphorus (P2O5) were synthesized using melt-quenching method. Prepared samples were characterized using various techniques to determine the effects of co-dopants concentration variation on their thermoluminescence (TL) and photoluminescence (PL) properties. TL glow curves of LMB:0.5Dy sample revealed a single prominent peak at Tm=190 °C, where TL intensity was enhanced by a factor of 2.5 with the increase of P2O5 concentration up to 1 mol%. This enhancement was accompanied by a shift in Tm towards higher temperature. Good linearity in the range of 1-100 Gy with linear correlation coefficient of 0.998 was achieved. PL spectra displayed two significant peaks centred at 481 nm and 573 nm. These attractive luminescence features of the proposed glass system may be useful for the development of radiation dosimetry.

  16. Single-molecule magnet behavior for an antiferromagnetically superexchange-coupled dinuclear dysprosium(III) complex.

    Science.gov (United States)

    Long, Jérôme; Habib, Fatemah; Lin, Po-Heng; Korobkov, Ilia; Enright, Gary; Ungur, Liviu; Wernsdorfer, Wolfgang; Chibotaru, Liviu F; Murugesu, Muralee

    2011-04-13

    A family of five dinuclear lanthanide complexes has been synthesized with general formula [Ln(III)(2)(valdien)(2)(NO(3))(2)] where (H(2)valdien = N1,N3-bis(3-methoxysalicylidene)diethylenetriamine) and Ln(III) = Eu(III)1, Gd(III)2, Tb(III)3, Dy(III)4, and Ho(III)5. The magnetic investigations reveal that 4 exhibits single-molecule magnet (SMM) behavior with an anisotropic barrier U(eff) = 76 K. The step-like features in the hysteresis loops observed for 4 reveal an antiferromagnetic exchange coupling between the two dysprosium ions. Ab initio calculations confirm the weak antiferromagnetic interaction with an exchange constant J(Dy-Dy) = -0.21 cm(-1). The observed steps in the hysteresis loops correspond to a weakly coupled system similar to exchange-biased SMMs. The Dy(2) complex is an ideal candidate for the elucidation of slow relaxation of the magnetization mechanism seen in lanthanide systems.

  17. A comparative study of donor formation in dysprosium, holmium, and erbium implanted silicon

    Energy Technology Data Exchange (ETDEWEB)

    Emtsev, V.V.; Emtsev, V.V. Jr.; Poloskin, D.S.; Shek, E.I.; Sobolev, N.A. [Division of Solid State Electronics, Ioffe Physicotechnical Institute, Russian Academy of Sciences, 194021 St. Petersburg (Russian Federation)

    1998-12-01

    Formation of donor centers in Czochralski grown silicon doped with dysprosium, holmium, and erbium is discussed. Donor states of three kinds are introduced in the implanted layers after annealing at T=700C. Shallow donor states with ionization energies between 20 and 40 meV are attributed to oxygen -related thermal donors. Other donor centers in the energy range of E{sub C}-(60...70) meV and E{sub C}-(100...120) meV appear to be dependent on dopants. After a 900C anneal strong changes in the donor formation are observed only in silicon doped with erbium. Instead of donors at E{sub C}-(118{+-}5) meV, new donor centres at E{sub C}-(145{+-}5) meV are formed. Reportedly, the latter ones are involved in the excitation process of the Er{sup 3+} ions with a characteristic luminescence line at {approx}1.54 {mu}m. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  18. Thermoluminescence properties of lithium magnesium borate glasses system doped with dysprosium oxide.

    Science.gov (United States)

    Mhareb, M H A; Hashim, S; Ghoshal, S K; Alajerami, Y S M; Saleh, M A; Razak, N A B; Azizan, S A B

    2015-12-01

    We report the impact of dysprosium (Dy(3+)) dopant and magnesium oxide (MgO) modifier on the thermoluminescent properties of lithium borate (LB) glass via two procedures. The thermoluminescence (TL) glow curves reveal a single prominent peak at 190 °C for 0.5 mol% of Dy(3+). An increase in MgO contents by 10 mol% enhances the TL intensity by a factor of 1.5 times without causing any shift in the maximum temperature. This enhancement is attributed to the occurrence of extra electron traps created via magnesium and the energy transfer to trivalent Dy(3+) ions. Good linearity in the range of 0.01-4 Gy with a linear correlation coefficient of 0.998, fading as low as 21% over a period of 3 months, excellent reproducibility without oven annealing and tissue equivalent effective atomic numbers ~8.71 are achieved. The trap parameters, including geometric factor (μg), activation energy (E) and frequency factor (s) associated with LMB:Dy are also determined. These favorable TL characteristics of prepared glasses may contribute towards the development of Li2O-MgO-B2O3 radiation dosimeters.

  19. Optical properties of zinc borotellurite glass doped with trivalent dysprosium ion

    Science.gov (United States)

    Ami Hazlin, M. N.; Halimah, M. K.; Muhammad, F. D.; Faznny, M. F.

    2017-04-01

    The zinc borotellurite doped with dysprosium oxide glass samples with chemical formula {[(TeO2) 0 . 7(B2O3) 0 . 3 ] 0 . 7(ZnO) 0 . 3 } 1 - x(Dy2O3)x (where x=0.01, 0.02, 0.03, 0.04 and 0.05 M fraction) were prepared by using conventional melt quenching technique. The structural and optical properties of the proposed glass systems were characterized by using X-ray diffraction (XRD) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, and UV-VIS spectroscopy. The amorphous nature of the glass systems is confirmed by using XRD technique. The infrared spectra of the glass systems indicate three obvious absorption bands which are assigned to BO3 and TeO4 vibrational groups. Based on the absorption spectra obtained, the direct and indirect optical band gaps, as well as the Urbach energy were calculated. It is observed that both the direct and indirect optical band gaps increase with the concentration of Dy3+ ions. On the other hand, the Urbach energy is observed to decrease as the concentration of Dy3+ ions increases.

  20. Isolation of {sup 163}Ho from dysprosium target material by HPLC for neutrino mass measurements

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Veronika; Taylor, Wayne A.; Nortier, Francois M.; Engle, Jonathan W.; Pollington, Anthony D.; Kunde, Gerd J.; Rabin, Michael W.; Birnbaum, Eva R. [Los Alamos National Laboratory, Los Alamos, NM (United States). Chemistry Div.; Barnhart, Todd E.; Nickles, Robert J. [Univ. Wisconsinn, Madison, WI (United States). Dept. of Medical Physics

    2015-07-01

    The rare earth isotope {sup 163}Ho is of interest for neutrino mass measurements. This report describes the isolation of {sup 163}Ho from a proton-irradiated dysprosium target and its purification. A Dy metal target was irradiated with 16 MeV protons for 10 h. After target dissolution, {sup 163}Ho was separated from the bulk Dy via cation-exchange high performance liquid chromatography using 70 mmol dm{sup -3} α-hydroxyisobutyric acid as the mobile phase. Subsequent purification of the collected Ho fraction was performed to remove the α-hydroxyisobutyrate chelating agent and to concentrate the Ho in a low ionic strength aqueous matrix. The final solution was characterized by MC-ICP-MS to determine the {sup 163}Ho/{sup 165}Ho ratio, {sup 163}Ho and the residual Dy content. The HPLC purification process resulted in a decontamination factor 1.4 x 10{sup 5} for Dy. The isolated Ho fraction contained 24.8 ± 1.3 ng of {sup 163}Ho corresponding to holmium recovery of 72 ± 3%.

  1. Acute dysprosium toxicity to Daphnia pulex and Hyalella azteca and development of the biotic ligand approach.

    Science.gov (United States)

    Vukov, Oliver; Smith, D Scott; McGeer, James C

    2016-01-01

    The toxicological understanding of rare earth elements (REEs) in the aquatic environment is very limited but of increasing concern. The objective of this research is to compare the toxicological effect of the REE dysprosium to the freshwater invertebrates Daphnia pulex and Hyalella azteca and in the more sensitive organism, understand the toxicity modifying influence of Ca, Na, Mg, pH and dissolved organic matter (DOM). Standard methods (Environment Canada) were followed for testing and culture in media of intermediate hardness (60mg CaCO3 mg/L) at pH 7.8 with Ca at 0.5, Na 0.5, Mg 0.125 (mM) and 23°C. Acute toxicity tests were done with azteca and D. pulex revealed Hyalella to be 1.4 times more sensitive than Daphnia. Additions of Ca and Na but not Mg provided significant protection against Dy toxicity to Hyalella. Similarly, low pH was associated with reduction in toxicity. Exposures which were pH buffered with and without MOPS were significantly different and indicated that MOPS enhanced Dy toxicity. DOM also mitigated Dy toxicity. Biotic ligand based parameters (LogK values) were calculated based on free ion relationships as determined by geochemical equilibrium modeling software (WHAM ver. 7.02). The logK value for Dy(3+) toxicity to Hyalella was 7.75 while the protective influence of Ca and Na were 3.95 and 4.10, respectively. This study contributes data towards the development of site specific water quality guidelines and criteria for Dy and possibly REEs in general and offers insight into the complex bio-geochemical nature of this element.

  2. 40 CFR 158.2080 - Experimental use permit data requirements-biochemical pesticides.

    Science.gov (United States)

    2010-07-01

    ... requirements-biochemical pesticides. 158.2080 Section 158.2080 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2080 Experimental use permit data requirements—biochemical pesticides. (a) Sections...

  3. Optical trapping of ultracold dysprosium atoms: transition probabilities, dynamic dipole polarizabilities and van der Waals C 6 coefficients

    Science.gov (United States)

    Li, H.; Wyart, J.-F.; Dulieu, O.; Nascimbène, S.; Lepers, M.

    2017-01-01

    The efficiency of the optical trapping of ultracold atoms depends on the atomic dynamic dipole polarizability governing the atom-field interaction. In this article, we have calculated the real and imaginary parts of the dynamic dipole polarizability of dysprosium in the ground and first excited levels. Due to the high electronic angular momentum of those two states, the polarizabilities possess scalar, vector and tensor contributions that we have computed, on a wide range of trapping wavelengths, using the sum-over-state formula. Using the same formalism, we have also calculated the C 6 coefficients characterizing the van der Waals interaction between two dysprosium atoms in the two lowest levels. We have computed the energies of excited states and the transition probabilities appearing in the sums, using a combination of ab initio and least-square-fitting techniques provided by the Cowan codes and extended in our group. Regarding the real part of the polarizability, for field frequencies far from atomic resonances, the vector and tensor contributions are two-orders-of-magnitude smaller than the scalar contribution, whereas for the imaginary part, the vector and tensor contributions represent a noticeable fraction of the scalar contribution. Finally, our anisotropic C 6 coefficients are much smaller than those published in the literature.

  4. Acute dysprosium toxicity to Daphnia pulex and Hyalella azteca and development of the biotic ligand approach

    Energy Technology Data Exchange (ETDEWEB)

    Vukov, Oliver, E-mail: vuko3930@mylaurier.ca [Biology Department, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5 (Canada); Smith, D. Scott [Chemistry Department, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5 (Canada); McGeer, James C. [Biology Department, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5 (Canada)

    2016-01-15

    The toxicological understanding of rare earth elements (REEs) in the aquatic environment is very limited but of increasing concern. The objective of this research is to compare the toxicological effect of the REE dysprosium to the freshwater invertebrates Daphnia pulex and Hyalella azteca and in the more sensitive organism, understand the toxicity modifying influence of Ca, Na, Mg, pH and dissolved organic matter (DOM). Standard methods (Environment Canada) were followed for testing and culture in media of intermediate hardness (60 mg CaCO{sub 3} mg/L) at pH 7.8 with Ca at 0.5, Na 0.5, Mg 0.125 (mM) and 23 °C. Acute toxicity tests were done with <24 h old neonates for 48 h in the case of D. pulex and with 2–9 days old offspring for 96 h tests with Hyalella. The potential protective effect of cationic competition was tested with Ca (0.5–2.0 mM), Na (0.5–2.0 mM) and Mg (0.125–0.5 mM). The effect of pH (6.5–8.0) and Suwannee River DOM complexation (at dissolved organic carbon (DOC) concentrations of 9 and 13 mg C/L) were evaluated. Dissolved Dy concentrations were lower than total (unfiltered) indicating precipitation, particularly at higher concentrations. Acute toxicity of Dy to H. azteca and D. pulex revealed Hyalella to be 1.4 times more sensitive than Daphnia. Additions of Ca and Na but not Mg provided significant protection against Dy toxicity to Hyalella. Similarly, low pH was associated with reduction in toxicity. Exposures which were pH buffered with and without MOPS were significantly different and indicated that MOPS enhanced Dy toxicity. DOM also mitigated Dy toxicity. Biotic ligand based parameters (Log K values) were calculated based on free ion relationships as determined by geochemical equilibrium modeling software (WHAM ver. 7.02). The log K value for Dy{sup 3+} toxicity to Hyalella was 7.75 while the protective influence of Ca and Na were 3.95 and 4.10, respectively. This study contributes data towards the development of site specific

  5. White light emission of dysprosium doped lanthanum calcium phosphate oxide and oxyfluoride glasses

    Science.gov (United States)

    Luewarasirikul, N.; Kim, H. J.; Meejitpaisan, P.; Kaewkhao, J.

    2017-04-01

    Lanthanum calcium phosphate oxide and oxyfluoride glasses doped with dysprosium oxide were prepared by melt-quenching technique with chemical composition 20La2O3:10CaO:69P2O5:1Dy2O3 and 20La2O3:10CaF2:69P2O5:1Dy2O3. The physical, optical and luminescence properties of the glass samples were studied to evaluate their potential to using as luminescence materials for solid-state lighting applications. The density, molar volume and refractive index of the glass samples were carried out. The optical and luminescence properties were studied by investigating absorption, excitation, and emission spectra of the glass samples. The absorption spectra were investigated in the UV-Vis-NIR region from 300 to 2000 nm. The excitation spectra observed under 574 nm emission wavelength showed the highest peak centered at 349 nm (6H15/2 → 6P7/2). The emission spectra, excited with 349 nm excitation wavelength showed two major peaks corresponding to 482 nm blue emission (4F9/2 → 6H15/2) and 574 nm yellow emission (4F9/2 → 6H13/2). The experimental lifetime were found to be 0.539 and 0.540 for oxide and oxyfluoride glass sample, respectively. The x,y color coordinates under 349 nm excitation wavelength were (0.38, 0.43) for both glass samples, that be plotted in white region of CIE 1931 chromaticity diagram. The CCT values obtained from the glass samples are 4204 K for oxide glass and 4228 K for oxyfluoride glass corresponding to the commercial cool white light (3100-4500 K). Judd-Ofelt theory had also been employed to obtain the J-O parameters (Ω2, Ω4 and Ω6), oscillator strength, radiative transition possibility, stimulated emission cross section and branching ratio. The Ω2 > Ω4 > Ω6 trend of J-O parameters of both glass samples may indicate the good quality of a glass host for using as optical device application. Temperature dependence of emission spectra was studied from 300 K to 10 K and found that the intensity of the emission peak was found to be increased with

  6. Ultrahigh Spin Structures in 157,158,159Er

    Institute of Scientific and Technical Information of China (English)

    MA Hai-Liang; DONG Bao-Guo; YAN Yu-Liang

    2008-01-01

    Rotational structures at ultrahigh spin in 157'158'159Er have been investigated with the configuration-dependent cranked Nilsson-Strutinsky approach. Configurations of observed bands are assigned and the corresponding deformations are given theoretically. The calculations suggest that one of ultrahigh spin bands in 158Er is triaxial highly deformed and the other is normal-deformed, while both ultrahigh spin bands in 157Er are suggested to be triaxial highly deformed. The possible ultrahigh spin bands in l59Er are predicted to be triaxial highly deformed and have shape coexistence in the same configuration. The configurations with two neutron holes in the Nosc=4 orbitals and two neutron holes in the h11/2 orbitals in 159Er are favoured for ultrahigh spin states but unfavoured for band termination, which is similar to ultrahigh spin bands in 157,158Er.

  7. Limits on violations of Lorentz symmetry and the Einstein equivalence principle using radio-frequency spectroscopy of atomic dysprosium.

    Science.gov (United States)

    Hohensee, M A; Leefer, N; Budker, D; Harabati, C; Dzuba, V A; Flambaum, V V

    2013-08-02

    We report a joint test of local Lorentz invariance and the Einstein equivalence principle for electrons, using long-term measurements of the transition frequency between two nearly degenerate states of atomic dysprosium. We present many-body calculations which demonstrate that the energy splitting of these states is particularly sensitive to violations of both special and general relativity. We limit Lorentz violation for electrons at the level of 10(-17), matching or improving the best laboratory and astrophysical limits by up to a factor of 10, and improve bounds on gravitational redshift anomalies for electrons by 2 orders of magnitude, to 10(-8). With some enhancements, our experiment may be sensitive to Lorentz violation at the level of 9 × 10(-20).

  8. Nonlinear optical properties of lutetium and dysprosium bisphthalocyanines at 1550 nm with femto- and nanosecond pulse excitation

    Science.gov (United States)

    Plekhanov, A. I.; Basova, T. V.; Parkhomenko, R. G.; Gürek, A. G.

    2017-02-01

    In this work, the nonlinear optical properties of unsubstituted lutetium (LuPc2) and dysprosium (DyPc2) bisphthalocyanines as well as octasubstituted Lu(PcR8)2 derivative with R=-S(C6H13) were studied at a wavelength of 1550 nm with 10 ns and 300 fs pulses. Based on Z-scan measurements the nonlinear absorption and refraction coefficient as well as the nature of nonlinear optical properties were analyzed for these materials. Open aperture Z-scan indicates strong two-photon absorption in all three bisphthalocyanines in nano- and femtosecond regimes. With good nonlinear optical coefficients, bisphthalocyanines of rare earth elements are expected to be promising materials for the creation of optical limiters.

  9. 40 CFR 158.355 - Enforcement analytical method.

    Science.gov (United States)

    2010-07-01

    ... DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.355 Enforcement analytical method. An analytical method suitable for enforcement purposes must be provided for each active ingredient in the... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Enforcement analytical method....

  10. Phenotype abnormality: 158 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 158 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u664i decreased efficiency... in organ named root hair cell during process named organ development ... root hair cell ... decreased efficiency ... organ development ...

  11. Image collection: 158 [Togo Picture Gallery[Archive

    Lifescience Database Archive (English)

    Full Text Available 158 Camelus_dromedarius_NL.png ヒトコブラクダ Dromedary Camelus dromedarius 9838 生物アイコン,脊索動物門,脊椎動物亜門,哺乳綱,獣亜綱,真獣下綱,ウシ目

  12. 40 CFR 158.2100 - Microbial pesticides definition and applicability.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides definition and...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2100 Microbial pesticides definition and applicability. (a) This subpart applies to all living or dead microbial pesticides as...

  13. 27 CFR 24.158 - Extent of relief.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Extent of relief. 24.158... Extent of relief. (a) General. The surety on any bond required by this part who has filed a notice for relief from liability as provided in § 24.157 will be relieved from liability under bond as set forth in...

  14. Spectroscopic data of the 1.8-, 2.9-, and 4.3- mu m transitions in dysprosium-doped gallium lanthanum sulfide glass

    Science.gov (United States)

    Schweizer, T.; Hewak, D. W.; Samson, B. N.; Payne, D. N.

    1996-10-01

    Infrared emission at 1.8, 2.9, and 4.3 mu m is measured in dysprosium-doped gallium lanthanum sulfide (Ga:La:S) glass excited at 815 nm. Emission cross sections were calculated by Judd-Ofelt analysis, the Fuchtbauer-Ladenburg equation, and the theory of McCumber. The sigma tau value for the 4.3- mu m transition is \\similar 4000 times larger in the Ga:La:S glass than in a dysprosium-doped LiYF4 crystal, which has lased on this transition. The large sigma tau value and the recently reported ability of Ga:La:S glass to be fabricated into fiber form show the potential for an efficient, low-threshold mid-infrared fiber laser. The fluorescence peak at 4.3 mu m coincides with the fundamental absorption of atmospheric carbon dioxide, making the glass a potential laser source for gas-sensing applications.

  15. Spectroscopic data of the 1.8-, 2.9-, and 4.3-microm transitions in dysprosium-doped gallium lanthanum sulfide glass.

    Science.gov (United States)

    Schweizer, T; Hewak, D W; Samson, B N; Payne, D N

    1996-10-01

    Infrared emission at 1.8, 2.9, and 4.3 microm is measured in dysprosium-doped gallium lanthanum sulfide (Ga:La:S) glass excited at 815 nm. Emission cross sections were calculated by Judd-Ofelt analysis, the Füchtbauer- Ladenburg equation, and the theory of McCumber. The sigmatau value for the 4.3-microm transition is ~4000 times larger in the Ga:La:S glass than in a dysprosium-doped LiYF(4) crystal, which has lased on this transition. The large sigmatau value and the recently reported ability of Ga:La:S glass to be fabricated into fiber form show the potential for an efficient, low-threshold mid-infrared fiber laser. The f luorescence peak at 4.3 microm coincides with the fundamental absorption of atmospheric carbon dioxide, making the glass a potential laser source for gas-sensing applications.

  16. On-line complexation/cloud point preconcentration for the sensitive determination of dysprosium in urine by flow injection inductively coupled plasma-optical emission spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Claudia; Cerutti, Soledad; Silva, Maria F. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Olsina, Roberto A.; Martinez, Luis D. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Avda. Rivadavia 1917, CP C1033AAJJ, Buenos Aires (Argentina)

    2003-01-01

    An on-line dysprosium preconcentration and determination system based on the hyphenation of cloud point extraction (CPE) to flow injection analysis (FIA) associated with ICP-OES was studied. For the preconcentration of dysprosium, a Dy(III)-2-(5-bromo-2-pyridylazo)-5-diethylaminophenol complex was formed on-line at pH 9.22 in the presence of nonionic micelles of PONPE-7.5. The micellar system containing the complex was thermostated at 30 C in order to promote phase separation, and the surfactant-rich phase was retained in a microcolumn packed with cotton at pH 9.2. The surfactant-rich phase was eluted with 4 mol L{sup -1} nitric acid at a flow rate of 1.5 mL min{sup -1}, directly in the nebulizer of the plasma. An enhancement factor of 50 was obtained for the preconcentration of 50 mL of sample solution. The detection limit value for the preconcentration of 50 mL of aqueous solution of Dy was 0.03 {mu}g L{sup -1}. The precision for 10 replicate determinations at the 2.0 {mu}g L{sup -1}Dy level was 2.2% relative standard deviation (RSD), calculated from the peak heights obtained. The calibration graph using the preconcentration system for dysprosium was linear with a correlation coefficient of 0.9994 at levels near the detection limits up to at least 100 {mu}g L {sup -1}. The method was successfully applied to the determination of dysprosium in urine. (orig.)

  17. The role of Ile87 of CYP158A2 in oxidative coupling reaction

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Bin; Bellamine, Aouatef; Lei, Li; Waterman, Michael R. (Vanderbilt)

    2012-05-15

    Both CYP158A1 and CYP158A2 are able to catalyze an oxidative C-C coupling reaction producing biflaviolin or triflaviolin in Streptomyces coelicolor A3(2). The substrate-bound crystal structures of CYP158A2 and CYP158A1 reveal that the side chain of Ile87 in CYP158A2 points to the active site contacting the distal flaviolin molecule, however, the bulkier side chain of Lys90 in CYP158A1 (corresponding to Ile87 in CYP158A2) is toward the distal surface of the protein. These results suggest that these residues could be important in determining product regiospecificity. In order to explore the role of the two residues in catalysis, the reciprocal mutants, Ile87Lys and Lys90Ile, of CYP158A2 and CYP158A1, respectively, were generated and characterized. The mutant Ile87Lys enzyme forms two isomers of biflaviolin instead of three isomers of biflaviolin in wild-type CYP158A2. CYP158A1 containing the substitution of lysine with isoleucine has the same catalytic activity compared with the wild-type CYP158A1. The crystal structure of Ile87Lys showed that the BC loop in the mutant is in a very different orientation compared with the BC loop in both CYP158A1/A2 structures. These results shed light on the mechanism of the oxidative coupling reaction catalyzed by cytochrome P450.

  18. Pole and Shape for the NEA (436724) 2011 UW158

    Science.gov (United States)

    Carbognani, Albino; Gary, Bruce L.; Oey, Julian; Baj, Giorgio; Bacci, Paolo

    2016-01-01

    The near-Earth asteroid (436724) 2011 UW158 was followed by an international team of observers on 31 nights between 2015 Jun 17 and Sep 26. By using the standard lightcurve inversion method with the combined photometry data set, we obtained a unique spin axis solution with ecliptic coordinates λ = 290° ± 3°, β = -39° ± 2°, a sidereal period Ps = 0.610752 ± 0.000001 h, and a shape model qualitatively consistent with radar observations.

  19. 75 FR 17823 - Notice-Interpretation of 49 CFR 158.45

    Science.gov (United States)

    2010-04-07

    ... any disputed amount and related finance or other charges, as applicable.'' 12 CFR Sec. 226.13(e)(1... processors, and the airports complies with 14 CFR Sections 158.45 and 158.49. We appreciate the importance of...

  20. 40 CFR 158.1010 - Applicator exposure-criteria for testing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Applicator exposure-criteria for testing. 158.1010 Section 158.1010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Human Exposure § 158.1010 Applicator...

  1. 40 CFR 158.510 - Tiered testing options for nonfood pesticides.

    Science.gov (United States)

    2010-07-01

    ... pesticides. 158.510 Section 158.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Toxicology § 158.510 Tiered testing options for nonfood pesticides. For nonfood use pesticides only, applicants have two options for generating and...

  2. 40 CFR 158.2170 - Experimental use permit data requirements-microbial pesticides.

    Science.gov (United States)

    2010-07-01

    ... requirements-microbial pesticides. 158.2170 Section 158.2170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2170 Experimental use permit data requirements—microbial pesticides. (a) For all microbial pesticides. (1)...

  3. 40 CFR 158.2130 - Microbial pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides residue data... (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2130 Microbial pesticides residue data requirements table. (a) General. Sections 158.100 through 158.130 describe how to...

  4. 40 CFR 158.2081 - Experimental use permit biochemical pesticides product chemistry data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides product chemistry data requirements table. 158.2081 Section 158.2081 Protection of Environment... Pesticides § 158.2081 Experimental use permit biochemical pesticides product chemistry data requirements... product chemistry data requirements for a particular biochemical pesticide product. Notes that apply to...

  5. 40 CFR 158.2171 - Experimental use permit microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides product analysis data requirements table. 158.2171 Section 158.2171 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2171 Experimental use permit microbial pesticides product analysis data requirements...

  6. 40 CFR 158.2172 - Experimental use permit microbial pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides residue data requirements table. 158.2172 Section 158.2172 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2172 Experimental use permit microbial pesticides residue data requirements table. (a)...

  7. 17 CFR 1.58 - Gross collection of exchange-set margins.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Gross collection of exchange-set margins. 1.58 Section 1.58 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous § 1.58 Gross collection of exchange-set...

  8. Synthesis and Crystal Structure of Tri-(2-mercaptopyridine N-oxide)bis(dimethyl sulfoxide) Dysprosium(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A range of rare earth metal complexes of 2-mercaptopyridine N-oxide (Hmpo) have been synthesized, and studied by elemental analysis and IR spectroscopic technique. Crystal structure of Dy(mpo)3(DMSO)2 (DMSO = dimethyl sulfoxide) has been determined. The complex crystallizes in the triclinic system, space group Pī with lattice parameters: a = 9.602(3), b = 9.803(3), c = 15.498(5)A, α= 89.51(1), β= 85.73(1), γ= 62.99(1)°, Dc = 1.787 g/cm3, C19H24N3O5S5Dy, Mr = 697.21, Z = 2, F(000) = 690, μ = 3.321mm-1, the final R = 0.0237 and wR = 0.0587 for 4116 reflections with I>σ2(I). The coordination number of dysprosium Ⅲ is eight, and its coordination geometry is a somewhat distorted square antiprism with O(3), O(4), O(5), S(3) and O(1), O(2), S(1), S(2) at the tetragonal bases (dihedral angle between their mean planes is 2.9(1)0). Around the Dy atom, three five-membered ring planes (Dy, O, N, C, S) make the dihedral angles of 74.42, 11.31 and 83.72, respectively.

  9. Photo-, cathodo- and thermoluminescent properties of dysprosium-doped HfO2 films deposited by ultrasonic spray pyrolysis.

    Science.gov (United States)

    Manríquez, R Reynoso; Góngora, J A I Díaz; Guzmán-Mendoza, J; Montalvo, T Rivera; Olguín, J C Guzmán; Ramírez, P V Cerón; García-Hipólito, M; Falcony, C

    2014-09-01

    In this work, the photoluminescent (PL), cathodoluminescent (CL) and thermoluminescent (TL) properties of hafnium oxide films doped with trivalent dysprosium ions are reported. The films were deposited on glass substrates at temperatures ranging from 300 to 600°C, using chlorides as precursor reagents. The surface morphology of films showed a veins shaped microstructure at low deposition temperatures, while at higher temperatures the formation of spherical particles was observed on the surface. X-ray diffraction showed the presence of HfO2 monoclinic phase in the films deposited at temperatures greater than 400°C. The PL and CL spectra of the doped films showed the highest emission band centered at 575nm corresponding to the transitions (4)F9/2→(6)H13/2, which is a characteristic transition of Dy(3+) ion. The greatest emission intensities were observed in samples doped with 1 atomic percent (at%) of DyCl3 in the precursor solution. Regarding the TL behavior, the glow curve of HfO2:Dy(+3) films exhibited spectrum with one broad band centered at about 150°C. The highest intensity TL response was observed on the films deposited at 500°C. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Workplace testing of the new single sphere neutron spectrometer based on Dysprosium activation foils (Dy-SSS)

    Science.gov (United States)

    Bedogni, R.; Gómez-Ros, J. M.; Esposito, A.; Gentile, A.; Chiti, M.; Palacios-Pérez, L.; Angelone, M.; Tana, L.

    2012-08-01

    A photon insensitive passive neutron spectrometer consisting of a single moderating polyethylene sphere with Dysprosium activation foils arranged along three perpendicular axes was designed by CIEMAT and INFN. The device is called Dy-SSS (Dy foil-based Single Sphere Spectrometer). It shows nearly isotropic response in terms of neutron fluence up to 20 MeV. The first prototype, previously calibrated with 14 MeV neutrons, has been recently tested in workplaces having different energy and directional distributions. These are a 2.5 MeV nearly mono-chromatic and mono-directional beam available at the ENEA Frascati Neutron Generator (FNG) and the photo-neutron field produced in a 15 MV Varian CLINAC DHX medical accelerator, located in the Ospedale S. Chiara (Pisa). Both neutron spectra are known through measurements with a Bonner Sphere Spectrometer. In both cases the experimental response of the Dy-SSS agrees with the reference data. Moreover, it is demonstrated that the spectrometric capability of the new device are independent from the directional distribution of the neutron field. This opens the way to a new generation of moderation-based neutron instruments, presenting all advantages of the Bonner sphere spectrometer without the disadvantage of the repeated exposures. This concept is being developed within the NESCOFI@BTF project of INFN (Commissione Scientifica Nazionale 5).

  11. Ferroelectric properties of dysprosium-doped Bi4Ti3O12 thin films crystallized in various atmospheres

    Institute of Scientific and Technical Information of China (English)

    CHENG Chuan-pin; TANG Ming-hua; YE Zhi; ZHOU Yic-hun; ZHENG Xue-jun; ZHONG Xiang-li; HU Zeng-shun

    2006-01-01

    Dysprosium-doped Bi4Ti3O12 (Bi3.4Dy0.6Ti3O12,BDT) ferroelectric thin films were deposited on Pt(111)/Ti/SiO2/Si(111) substrates by chemical solution deposition (CSD) and crystallized in nitrogen,air and oxygen atmospheres,respectively. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to identify the crystal structure,the surface and cross-section morphology of the deposited ferroelectric films. The results show that the crystallization atmosphere has significant effect on determining the crystallization and ferroelectric properties of the BDT films. The film crystallized in nitrogen at a relatively low temperature of 650 ℃,exhibits excellent crystallinity and ferroelectricity with a remanent polarization of 2Pr = 24.9 μC/cm2 and a coercive field of 144.5 kV/cm. While the films annealed in air and oxygen at 650 ℃ do not show good crystallinity and ferroelectricity until they are annealed at 700 ℃. The structure evolution and ferroelectric properties of BDT thin films annealed under different temperatures (600-750 ℃) were also investigated. The crystallinity of the BDT films is improved and the average grain size increases when the annealing temperature increases from 600 ℃ to 750 ℃ at an interval of 50 ℃. However,the polarization of the films is not monotonous function of the annealing temperature.

  12. FIRAS map of C+ 158 Aum spectral line

    Science.gov (United States)

    2002-01-01

    FIRAS map of C+ 158 Aum spectral line intensity from Bennett et al. 1994, Astrophysical Journal, 434, 587, 'Morphology of the Interstellar Cooling Lines Detected by COBE.' The map is a projection of the full sky in Galactic coordinates. The plane of the Milky Way is horizontal in the middle of the map with the Galactic center at the center. The C+ line is an important coolant of the interstellar gas, in particular the 'Cold Neutral Medium' (e.g., surfaces of star-forming molecular clouds). In contrast, the N+ line emission (see slide 31) arises entirely from the 'Warm Ionized Medium' which surrounds hot stars.

  13. The (C II) 158 micron line mapping of spiral galaxies

    Science.gov (United States)

    Stacey, Gordon J.; Geis, N.; Genzel, Reinhard; Jackson, J. M.; Poglitsch, Albrecht; Townes, Charles H.

    1990-01-01

    Large scale maps of the face of spiral galaxies M51, M83, and NGC 6946 in the 158 micron (C II) fine structure line. The maps are obtained from the Far-infrared Imaging Fabry-Perot Interferometer (FIFI) during its first series of flights on board the Kuiper Airborne Observatory. The (C II) line emission is ubiquitous and easily traced over the mapped regions of each of the galaxies. The (C II) maps are compared with those obtained with similar sized beams in the CO line. The data available from these maps is interpreted.

  14. Sensitive search for the temporal variation of the fine structure constant using radio-frequency E1 transitions in atomic dysprosium

    CERN Document Server

    Nguyen, A T; Lamoreaux, S K; Torgerson, J R

    2003-01-01

    It has been proposed that the radio-frequency electric-dipole (E1) transition between two nearly degenerate opposite-parity states in atomic dysprosium should be highly sensitive to possible temporal variation of the fine structure constant ($\\alpha$) [V. A. Dzuba, V. V. Flambaum, and J. K. Webb, Phys. Rev. A {\\bf 59}, 230 (1999)]. We discuss here an experimental realization of the proposed search, which involves monitoring the E1 transition frequency over a period of time using direct frequency counting techniques. We estimate that a statistical sensitivity of $|\\adota| \\sim 10^{-18}$/yr may be achieved and discuss possible systematic effects in such a measurement.

  15. Radar observations of the asteroid 2011 UW158

    Science.gov (United States)

    Ipatov, A. V.; Bondarenko, Yu. S.; Medvedev, Yu. D.; Mishina, N. A.; Marshalov, D. A.; Benner, L. A.

    2016-12-01

    In July 2015 intercontinental bistatic radar observations of the potentially dangerous asteroid 2011 UW158 during its close approach to the Earth were carried out. The asteroid was illuminated at a frequency of 8.4 GHz with the 70-m DSS-14 antenna of the Goldstone Deep Space Communications Complex, while the signal reflected from the asteroid was received with the 32-m radio telescopes of the Quasar VLBI network at the Zelenchukskaya and Badary Observatories. The spectra of the reflected radio signals were obtained. The sizes and rotation period of the asteroid consistent with photometric observations and the ratio of the powers of the reflected signals with left- and right-hand circular polarizations were determined. The derived values suggest that the asteroid has an inhomogeneous surface and a prolate shape. The observations of the Doppler shift of the reflected signal frequency were obtained, which allowed the orbital parameters of the asteroid to be improved.

  16. Dysprosium doping induced shape and magnetic anisotropy of Fe3-xDyxO4 (x=0.01-0.1) nanoparticles

    Science.gov (United States)

    Jain, Richa; Luthra, Vandna; Gokhale, Shubha

    2016-09-01

    The effect of dysprosium doping on evolution of structural and magnetic properties of magnetite (Fe3O4) nanoparticles is reported. A standard route of co-precipitation was used for the synthesis of undoped and doped magnetite nanoparticles Fe3-xDyxO4 (x=0.0-0.1). Transmission electron microscopy (TEM) shows formation of round shaped particles with diameter in the range of 8-14 nm for undoped sample. On doping beyond x=0.01, the formation of rod like structures is initiated along with the round shaped particles. The number of rods is found to increase with increasing doping concentration. Magnetic characterization using Vibrating Sample Magnetometer (VSM) revealed doping dependent magnetic properties which can be correlated with the crystallite size as determined from X-ray diffraction (XRD). Enhancement in the saturation magnetization in the initial stages of doping can be explained on the basis of incorporation of Dy3+ ions in the inverse spinel structure at the octahedral site in place of Fe3+ ions. Subsequent decrease in saturation magnetization observed beyond x=0.03 could be attributed to precipitation of excess Dy in form of dysprosium ferrite phase.

  17. Cause analysis of 158 cases of perinatal death%158例围产儿死亡原因分析

    Institute of Scientific and Technical Information of China (English)

    张丽欣; 张爱青; 高素红; 赵银珠; 周钰

    2016-01-01

    Objective To make related intervention measures to reduce perinatal mortality rate through analyzing causes and factors of 158 cases of perinatal mortality in Haidian Maternal and Child Health Hospital .Methods Retrospective analysis was conducted on perinatal data of 158 cases delivered and evaluated with death discussion in the hospital from April 2010 to December 2013.Results Perinatal mortality rate of the hospital was 3.24‰.The common death causes were the followings:birth defects (32.28%), umbilical cord factors (27.85%), unexplained stillbirth (9.50%), premature (8.86%), placental abruption (6.96%) and early-onset preeclampsia (5.06%).Conclusion In order to reduce perinatal mortality rate , health education for fertile and pregnant women should be strengthened so as to improve their self-care consciousness and basic perinatal care knowledge .Pregnancy management , screening and diagnosis should also be enhanced and intervention measures should be taken to reduce perinatal defects .The management of high-risk pregnant women should be strengthened to prevent and cure complications effectively .%目的:分析北京市海淀区妇幼保健院158例围产儿死亡原因及相关因素,制订相应的干预措施,降低围产儿死亡率。方法对2010年4月至2013年12月于北京市海淀区妇幼保健院分娩并经死亡评审讨论的158例围产儿资料进行回顾性分析。结果围产儿死亡率为3.24‰。常见死亡原因依次为出生缺陷(32.28%)、脐带因素(27.85%)、不明原因死胎(9.50%)、早产(8.86%)、胎盘早剥(6.96%)、早发型子痫前期(5.06%)。结论要降低围产儿死亡率,必须加强健康教育,提高孕产妇孕前以及孕期保健意识;严格孕期管理,加强产前筛查与诊断,采取干预措施,降低围产儿出生缺陷的发生;加强高危孕妇管理,积极有效防治妊娠并发症和合并症。

  18. COMT Val158Met genotypes differentially influence subgenual cingulate functional connectivity in healthy females

    Directory of Open Access Journals (Sweden)

    Chris eBaeken

    2014-06-01

    Full Text Available Brain imaging studies have consistently shown subgenual Anterior Cingulate Cortical (sgACC involvement in emotion processing. COMT Val158 and Met158 polymorphisms may influence such emotional brain processes in specific ways. Given that resting-state fMRI (rsfMRI may increase our understanding on brain functioning, we integrated genetic and rsfMRI data and focused on sgACC functional connections. No studies have yet investigated the influence of the COMT Val158Met polymorphism (rs4680 on sgACC resting-state functional connectivity (rsFC in healthy individuals. A homogeneous group of sixty-one Caucasian right-handed healthy female university students, all within the same age range, underwent rsfMRI. Compared to Met158 homozygotes, Val158 allele carriers displayed significantly stronger rsFC between the sgACC and the left parahippocampal gyrus, ventromedial parts of the inferior frontal gyrus, and the nucleus accumbens (NAc. On the other hand, compared to Val158 homozygotes, we found in Met158 allele carriers stronger sgACC rsFC with the medial frontal gyrus, more in particular the anterior parts of the medial orbitofrontal cortex. Although we did not use emotional or cognitive tasks, our sgACC rsFC results point to possible distinct differences in emotional and cognitive processes between Val158 and Met158 allele carriers. However, the exact nature of these directions remains to be determined.

  19. [A study of 158 cases of acute delta hepatitis].

    Science.gov (United States)

    Castro, A; Buti, M; Esteban, R; Jardí, R; Allende, H; Roget, M; Rodríguez-Frías, F; Guardia, J

    1990-09-22

    We have prospectively studied 158 cases of acute hepatitis delta observed during the last 7 years in a general hospital. Among them 136 were male and 22 female. The mean age was 22.7 years with a range between 16 and 61 years. The epidemiologic factors were drug addiction by parenteral route in 145 cases (92%), sexual transmission in 5 (3%), post transfusional in 2 (1%) and unknown in 6 (4%). With respect to the delta type infection, 105 cases (66%) were coinfections with type B and delta, and 53 patients had a type delta superinfection (34%). The clinical course was a fulminant hepatitis in three cases (two cases of coinfection B and delta an one case of delta superinfection), and an acute benign hepatitis in 155 patients. The follow-up of 118 patients revealed that 96% of coinfections by type B and delta evolved to the chronicity showing findings of active chronic hepatitis or hepatic cirrhosis. It should be noted that in 4 cases of superinfection delta type (11%) the HBsAg was negative after several months of positivity. In these patients the level of transaminases normalized and the hepatic histology evidenced alterations of chronic active hepatitis (2 cases) and hepatic cirrhosis (2 cases) without identification of tissular delta antigen.

  20. The Local [CII] 158 um Emission Line Luminosity Function

    CERN Document Server

    Hemmati, Shoubaneh; Diaz-Santos, Tanio; Armus, Lee; Capak, Peter; Faisst, Andreas; Masters, Daniel

    2016-01-01

    We present, for the first time, the local [CII] 158 um emission line luminosity function measured using a sample of more than 500 galaxies from the Revised Bright Galaxy Sample (RBGS). [CII] luminosities are measured from the Herschel PACS observations of the Luminous Infrared Galaxies in the Great Observatories All-sky LIRG Survey (GOALS) and estimated for the rest of the sample based on the far-IR luminosity and color. The sample covers 91.3% of the sky and is complete at S_60 um > 5.24 Jy. We calculated the completeness as a function of [CII] line luminosity and distance, based on the far-IR color and flux densities. The [CII] luminosity function is constrained in the range ~10^(7-9) (Lo) from both the 1/V_max and a maximum likelihood methods. The shape of our derived [CII] emission line luminosity function agrees well with the IR luminosity function. For the CO(1-0) and [CII] luminosity functions to agree, we propose a varying ratio of [CII]/CO(1-0) as a function of CO luminosity, with larger ratios for f...

  1. 158th Symposium of the International Astronomical Union

    CERN Document Server

    Tango, W

    1994-01-01

    The 1990s are proving to be a very exciting p&iod for high angular resolution astronomy. At radio wavelengths a combination of new array instruments and pow­ erful imaging algorithms have generated images of unprecedented resolution and quality. In the optical and infrared, the great technical difficulties associated with constructing separated-aperture interferometers have been largely overcome, and many new instruments are now operating or are being developed. As these pro­ grams start to produce observational results they will be able to draw extensively on the experience gained by the radio-interferometry community. Thus it seemed that the time was ripe for a meeting which would bring together workers from all wavelength ranges to discuss the details of the science and art of "Very High Angular Resolution Imaging" . While the main emphasis of Symposium No. 158 was on high resolution tech­ niques from the radio, mm-wave, infrared and optical bands, it also provided an opportunity for presentation of...

  2. Hydrogen production by Rhodobacter sphaeroides DSM 158 under intense irradiation.

    Science.gov (United States)

    Krujatz, Felix; Härtel, Paul; Helbig, Karsten; Haufe, Nora; Thierfelder, Simone; Bley, Thomas; Weber, Jost

    2015-01-01

    To identify optimal hydrogen production conditions using growing cultures of Rhodobacter sphaeroides DSM 158 the effects of varying the reactor's volumetric power input (0.01-1.4kWm(-3)) and irradiation intensity (5-2500Wm(-2)) were investigated in batch and continuous production modes. Irradiation intensity had a greater effect on hydrogen production than volumetric power input. Hydrogen production and photofermentative biomass formation were maximized by irradiation at 2250Wm(-2) with a volumetric power input of 0.55kWm(-3). The bacterial dry weight (2.64gL(-1)) and rate of hydrogen production (195mLL(-1)h(-1)) achieved under these conditions were greater than any that have previously been reported for batch-mode hydrogen production by R. sphaeroides. Continuous mode experiments (D=0.1h(-1)) yielded a bacterial dry weight, hydrogen production rate, productivity and hydrogen yield of 2.35±0.18gL(-1), 165±6.2mLL(-1)h(-1), 3.96LL(-1)d(-1) and 36.6%, respectively.

  3. 40 CFR 158.230 - Experimental use permit data requirements for toxicology.

    Science.gov (United States)

    2010-07-01

    ... requirements for toxicology. 158.230 Section 158.230 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Experimental use permit data requirements for toxicology. All toxicology data, as described in paragraph (c) of...) Table. The following table shows the experimental use data requirements for toxicology. The test...

  4. 14 CFR 158.30 - PFC Authorization at Non-Hub Airports.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false PFC Authorization at Non-Hub Airports. 158... (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.30 PFC Authorization at Non-Hub Airports. (a) General. This section specifies the procedures a public agency controlling...

  5. 7 CFR 1717.158 - Mergers with borrowers who prepaid RUS loans.

    Science.gov (United States)

    2010-01-01

    ... has prepaid RUS debt at a discount pursuant to 7 CFR part 1786, and whose eligibility for future RUS... 7 Agriculture 11 2010-01-01 2010-01-01 false Mergers with borrowers who prepaid RUS loans. 1717.158 Section 1717.158 Agriculture Regulations of the Department of Agriculture (Continued)...

  6. 40 CFR 158.210 - Experimental use permit data requirements for product chemistry.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Experimental use permit data requirements for product chemistry. 158.210 Section 158.210 Protection of Environment ENVIRONMENTAL PROTECTION... Experimental use permit data requirements for product chemistry. All product chemistry data, as described in...

  7. 40 CFR 158.270 - Experimental use permit data requirements for residue chemistry.

    Science.gov (United States)

    2010-07-01

    ... requirements for residue chemistry. 158.270 Section 158.270 Protection of Environment ENVIRONMENTAL PROTECTION... Experimental use permit data requirements for residue chemistry. All residue chemistry data, as described in... section 408(r) is sought. Residue chemistry data are not required for an experimental use permit issued on...

  8. 40 CFR 158.2120 - Microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides product analysis... AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2120 Microbial pesticides product analysis data requirements table. (a) General. Sections 158.100 through...

  9. 14 CFR 158.35 - Extension of time to submit application to use PFC revenue.

    Science.gov (United States)

    2010-01-01

    ... use PFC revenue. 158.35 Section 158.35 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION.... The notice shall include progress on the project, a revised schedule for obtaining project approval..., shall be accompanied by the following: (1) A description of progress on the project application to...

  10. 40 CFR 158.660 - Nontarget plant protection data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Nontarget plant protection data... protection data requirements table. (a) General. Sections 158.100 through158.130 describe how to use this... table shows the nontarget plant protection data requirements. The table notes are shown in paragraph...

  11. 40 CFR 158.2083 - Experimental use permit biochemical pesticides human health assessment data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides human health assessment data requirements table. 158.2083 Section 158.2083 Protection of... determine the human health assessment data requirements for a particular biochemical pesticide product. (2.... Table—EUP Biochemical Pesticides Human Health Assessment Data Requirements Guideline Number Data...

  12. 34 CFR 222.158 - What procedures apply to the Secretary's review of an initial decision?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What procedures apply to the Secretary's review of an initial decision? 222.158 Section 222.158 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION IMPACT AID PROGRAMS...

  13. Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression.

    Directory of Open Access Journals (Sweden)

    Nitin Patel

    Full Text Available Prostate cancer (PCa is the second-leading cause of cancer-related mortality, after lung cancer, in men from developed countries. In its early stages, primary tumor growth is dependent on androgens, thus generally can be controlled by androgen deprivation therapy (ADT. Eventually however, the disease progresses to castration-resistant prostate cancer (CRPC, a lethal form in need of more effective treatments. G-protein coupled receptors (GPCRs comprise a large clan of cell surface proteins that have been implicated as therapeutic targets in PCa growth and progression. The findings reported here provide intriguing evidence of a role for the newly characterized glutamate family member GPR158 in PCa growth and progression. We found that GPR158 promotes PCa cell proliferation independent of androgen receptor (AR functionality and that this requires its localization in the nucleus of the cell. This suggests that GPR158 acts by mechanisms different from other GPCRs. GPR158 expression is stimulated by androgens and GPR158 stimulates AR expression, implying a potential to sensitize tumors to low androgen conditions during ADT via a positive feedback loop. Further, we found GPR158 expression correlates with a neuroendocrine (NE differentiation phenotype and promotes anchorage-independent colony formation implying a role for GPR158 in therapeutic progression and tumor formation. GPR158 expression was increased at the invading front of prostate tumors that formed in the genetically defined conditional Pten knockout mouse model, and co-localized with elevated AR expression in the cell nucleus. Kaplan-Meier analysis on a dataset from the Memorial Sloan Kettering cancer genome portal showed that increased GPR158 expression in tumors is associated with lower disease-free survival. Our findings strongly suggest that pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of CRPC.

  14. COMT Val158Met Polymorphism Modulates Huntington's Disease Progression

    Science.gov (United States)

    Rebeix, Isabelle; Dupoux, Emmanuel; Durr, Alexandra; Brice, Alexis; Charles, Perrine; Cleret de Langavant, Laurent; Youssov, Katia; Verny, Christophe; Damotte, Vincent; Azulay, Jean-Philippe; Goizet, Cyril; Simonin, Clémence; Tranchant, Christine; Maison, Patrick; Rialland, Amandine; Schmitz, David; Jacquemot, Charlotte; Fontaine, Bertrand; Bachoud-Lévi, Anne-Catherine

    2016-01-01

    Little is known about the genetic factors modulating the progression of Huntington’s disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, affects clinical progression in HD. We carried out a prospective longitudinal multicenter study from 1994 to 2011, on 438 HD gene carriers at different stages of the disease (34 pre-manifest; 172 stage 1; 130 stage 2; 80 stage 3; 17 stage 4; and 5 stage 5), according to Total Functional Capacity (TFC) score. We used the Unified Huntington’s Disease Rating Scale to evaluate motor, cognitive, behavioral and functional decline. We genotyped participants for COMT polymorphism (107 Met-homozygous, 114 Val-homozygous and 217 heterozygous). 367 controls of similar ancestry were also genotyped. We compared clinical progression, on each domain, between groups of COMT polymorphisms, using latent-class mixed models accounting for disease duration and number of CAG (cytosine adenine guanine) repeats. We show that HD gene carriers with fewer CAG repeats and with the Val allele in COMT polymorphism displayed slower cognitive decline. The rate of cognitive decline was greater for Met/Met homozygotes, which displayed a better maintenance of cognitive capacity in earlier stages of the disease, but had a worse performance than Val allele carriers later on. COMT polymorphism did not significantly impact functional and behavioral performance. Since COMT polymorphism influences progression in HD, it could be used for stratification in future clinical trials. Moreover, DA treatments based on the specific COMT polymorphism and adapted according to disease duration could potentially slow HD progression. PMID:27657697

  15. Vertebrados silvestres atropelados na BR 158, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Daniela da Silva Oliveira

    2012-09-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2012v25n4p229   Entre os problemas que ameaçam a fauna silvestre, o atropelamento de animais é uma importante causa de mortalidade para várias espécies. O presente estudo visou identificar as espécies vitimadas por atropelamento em 98km da rodovia BR 158, entre o município de Cruz Alta e o distrito de Val de Serra, município de Júlio de Castilhos, RS e analisar as variações mensais nas taxas de atropelamento e sua correlação com o volume mensal de chuvas. Foram realizadas expedições mensais, entre os meses de abril a setembro de 2007, onde se registrou 61 animais atropelados pertencentes a 15 espécies, com uma taxa de atropelamento de 0,10 ind./km/mês. As espécies com maior número de atropelamentos foram o zorrilho (Conepatus chinga, com 17 indivíduos (28%, seguida pelo graxaim-do-campo (Lycalopex gymnocercus, com sete (11% e o graxaim-do-mato (Cerdocyon thous, com cinco (8%. Não foi encontrada diferença nas taxas de atropelamento entre os meses amostrados, contudo, o mês com maior registro de atropelamentos foi setembro (n=18. Também não foi verificada correlação entre os atropelamentos e a precipitação mensal, no entanto, há uma tendência entre a ocorrência dos atropelamentos com um volume maior de chuvas.

  16. Single-molecule magnet behavior in an octanuclear dysprosium(iii) aggregate inherited from helical triangular Dy3 SMM-building blocks.

    Science.gov (United States)

    Zhang, Li; Zhang, Peng; Zhao, Lang; Wu, Jianfeng; Guo, Mei; Tang, Jinkui

    2016-06-28

    An unprecedented octanuclear dysprosium(iii) cluster with the formula [Dy8L6(μ3-OH)4(μ2-CH3O)2(CH3OH)6(H2O)2]·6H2O·10CH3OH·2CH3CN () based on a nonlinearly tritopic aroylhydrazone ligand H3L has been isolated, realizing the successful linking of pairwise interesting triangular Dy3 SMMs. It is noteworthy that two enantiomers (Λ and Δ configurations) individually behaving as a coordination-induced chirality presented in the Dy3 helicate are connected in the meso Dy8 cluster. Remarkably, alternating-current magnetic susceptibility measurements revealed that the Dy8 cluster shows typical SMM behavior inherited from its Dy3 helical precursor. It is one of the rare polynuclear Lnn SMMs (n > 7) under zero dc field.

  17. Another challenge to paramagnetic relaxation theory: a study of paramagnetic proton NMR relaxation in closely related series of pyridine-derivatised dysprosium complexes.

    Science.gov (United States)

    Rogers, Nicola J; Finney, Katie-Louise N A; Senanayake, P Kanthi; Parker, David

    2016-02-14

    Measurements of the relaxation rate behaviour of two series of dysprosium complexes have been performed in solution, over the field range 1.0 to 16.5 Tesla. The field dependence has been modelled using Bloch-Redfield-Wangsness theory, allowing estimates of the electronic relaxation time, T1e, and the size of the magnetic susceptibility, μeff, to be made. Changes in relaxation rate of the order of 50% at higher fields were measured, following variation of the para-substituent in the single pyridine donor. The magnetic susceptibilities deviated unexpectedly from the free-ion values for certain derivatives in each series examined, in a manner that was independent of the electron-releasing/withdrawing ability of the pyridine substituent, suggesting that the polarisability of just one pyridine donor in octadenate ligands can play a significant role in defining the magnetic susceptibility anisotropy.

  18. Catechol-O-Methyltransferase gene val158met polymorphism and depressive symptoms during early childhood

    Science.gov (United States)

    Sheikh, Haroon I.; Kryski, Katie R.; Smith, Heather J.; Dougherty, Lea R.; Klein, Daniel N.; Bufferd, Sara J.; Singh, Shiva M.; Hayden, Elizabeth P.

    2017-01-01

    Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns = 476 and 409). In both samples, preschool-aged children were genotyped for the COMT val158met polymorphism. Symptoms of psychopathology were assessed via parent interviews and primary caregiver reports. In both samples, children homozygous for the val allele had higher levels of depressive symptoms compared to children with at least one copy of the met allele. Our findings extend previous research in older participants by showing links between the COMT val158met polymorphism and internalizing symptoms in early childhood. PMID:23475824

  19. Comprehensive treatment of 158 cases with attention deficit hyperactivity disorder%注意缺陷多动障碍158例的综合治疗

    Institute of Scientific and Technical Information of China (English)

    张洁; 闫素玲

    2014-01-01

    目的:探讨注意缺陷多动障碍(ADHD)的治疗疗效。方法:2012年1月1日-2012年12月31日有158例ADHD 患者来我科咨询、治疗、接受指导。根据患者具体情况给予家庭教育、药物和行为治疗。观察疗效。结果:158例 ADHD 经治疗症状都有所改善。11例青春期患儿治疗效果不如140例儿童效果显著,7例成人症状明显减轻。结论:应早期发现,早期治疗ADHD,以提高生活质量。%Objective: To explore the treatment of attention deficit hyperactivity disorder (ADHD).Methods:From January 1, 2012 to December 31,2012, 158 cases with ADHD come to consult, treat, and accept guidance.158 cases were given family education , medication and behavioral therapy on the basis of the condition of the patients,.Observe curative effect.Results: Symptoms of 158 cases of ADHD after treatment were improved. The treatment effect of 11 cases of children with adolescent was remarkablely better than that of 140 cases . The symptoms of 7 cases of adult significantly reduce.Conclusion: ADHD should be found early, and early treatment, in order to improve the quality of life.

  20. Tuning the composition and magnetostructure of dysprosium iron garnets by Co-substitution: An XRD, FT-IR, XPS and VSM study

    Energy Technology Data Exchange (ETDEWEB)

    Tholkappiyan, R.; Vishista, K., E-mail: raovishista@gmail.com

    2015-10-01

    Graphical abstract: - Highlights: • Garnet type Dy{sub 3}Fe{sub 5−x}Co{sub x}O{sub 12} (x = 0–0.06) nanoparticles were synthesized by glycine assisted combustion method. • To investigate and confirm the phases in the synthesized ferrite nanoparticles by FT-IR and XRD analysis. • To investigate the compositional and oxidation state of the samples by X-ray photoelectron spectroscopy. • The detailed core level spectra of Dy 4d, Fe 2p, Co 2p and O 1s were analyzed using XPS. • The magnetic property was studied by VSM technique. - Abstract: We report the Co-substituting on the synthesis and properties of garnet type dysprosium ferrite nanoparticles by basic composition Dy{sub 3}Fe{sub 5−x}Co{sub x}O{sub 12} (x = 0–0.06) synthesized through glycine assisted combustion method. A possible formation mechanism of synthesized Dy{sub 3}Fe{sub 5−x}Co{sub x}O{sub 12} samples by controlling the synthesis process has been proposed. XRD, FT-IR, XPS and VSM studies were used to investigate the compositional and magnetostructural properties of the prepared nanoparticles. XRD results confirm that all the samples are single-phase cubic garnet structure with mean crystallite size of 97–105 nm obtained from Scherrer method and 95–102 nm from W–H method. FT-IR analysis shows the presence of three expected bands in the frequency limit of 450–600 cm{sup −1} attributed to metal–O stretching vibration in tetrahedral site of garnet structure. A typical survey spectrum from XPS results confirmed the presence of Dy, Fe, Co and O elements in the samples. This study also to characterize the different oxidation states of the samples by fitting the parameters of high resolution Dy 4d, Fe 2p, Co 2p and O 1s XPS spectra. The XPS data of Dy 4d spectrum show that Dy{sup 3+} ion occupy in dodecahedral (D) site. The XPS analysis of Fe 2p and Co 2p data suggests that (Fe{sup 3+} and Fe{sup 2+}), (Co{sup 3+} and Co{sup 2+}) are distributed in tetrahedral and octahedral sites

  1. A dysprosium-based metal-organic framework: Synthesis, characterization, crystal structure and interaction with calf thymus-DNA and bovine serum albumin

    Indian Academy of Sciences (India)

    Biplab Mondal; Buddhadeb Sen; Ennio Zangrando; Pabitra Chattopadhyay

    2014-07-01

    A dysprosium-based metallo-organic framework (MOF) containing calcium ions formulated as {Dy(pyda)3Ca1.5(H2O)6} · 5.5H2O (1) (H2pyda = pyridine-2,6-dicarboxylic acid) was solvothermally synthesized in ethanolic medium and characterized by physico-chemical and spectroscopic tools. A detailed structural analysis of the solid state structure of 1 by single crystal X-ray diffraction study showed a tricapped trigonal prism geometry for lanthanide in the [Dy(pyda)3]3− fragment. The mode of interaction of 1 with calf thymus- DNA and with protein bovine serum albumin (BSA) was investigated by using absorption and emission spectroscopic tools. The apparent association constant of complex 1 with CT-DNA was deduced from an absorption spectral study (b = 4.08 × 104 M-1). Spectral and viscosity measurements indicated a groove-binding mode of 1 with CT-DNA, and from spectroscopic study the formation of a metal complex-BSA adduct was assumed to be the result of the interaction of 1 with BSA.

  2. Dual-mode T1 and T2 magnetic resonance imaging contrast agent based on ultrasmall mixed gadolinium-dysprosium oxide nanoparticles: synthesis, characterization, and in vivo application

    Science.gov (United States)

    Tegafaw, Tirusew; Xu, Wenlong; Wasi Ahmad, Md; Baeck, Jong Su; Chang, Yongmin; Bae, Ji Eun; Chae, Kwon Seok; Kim, Tae Jeong; Lee, Gang Ho

    2015-09-01

    A new type of dual-mode T1 and T2 magnetic resonance imaging (MRI) contrast agent based on mixed lanthanide oxide nanoparticles was synthesized. Gd3+ (8S7/2) plays an important role in T1 MRI contrast agents because of its large electron spin magnetic moment resulting from its seven unpaired 4f-electrons, and Dy3+ (6H15/2) has the potential to be used in T2 MRI contrast agents because of its very large total electron magnetic moment: among lanthanide oxide nanoparticles, Dy2O3 nanoparticles have the largest magnetic moments at room temperature. Using these properties of Gd3+ and Dy3+ and their oxide nanoparticles, ultrasmall mixed gadolinium-dysprosium oxide (GDO) nanoparticles were synthesized and their potential to act as a dual-mode T1 and T2 MRI contrast agent was investigated in vitro and in vivo. The D-glucuronic acid coated GDO nanoparticles (davg = 1.0 nm) showed large r1 and r2 values (r2/r1 ≈ 6.6) and as a result clear dose-dependent contrast enhancements in R1 and R2 map images. Finally, the dual-mode imaging capability of the nanoparticles was confirmed by obtaining in vivo T1 and T2 MR images.

  3. Experimental and molecular dynamics studies of dysprosium(III) salt solutions for a better representation of the microscopic features used within the binding mean spherical approximation theory.

    Science.gov (United States)

    Ruas, Alexandre; Guilbaud, Philippe; Den Auwer, Christophe; Moulin, Christophe; Simonin, Jean-Pierre; Turq, Pierre; Moisy, Philippe

    2006-10-19

    This work is aimed at a predictive description of the thermodynamic properties of actinide(III) salt solutions at high concentration and 25 degrees C. A new solution of the binding mean spherical approximation (BIMSA) theory, based on the Wertheim formalism, for taking into account 1:1 and also 1:2 complex formation, is used to reproduce, from a simple procedure, experimental osmotic coefficient variation with concentration for three binary salt solutions of the same lanthanide(III) cation: dysprosium(III) perchlorate, nitrate, and chloride. The relevance of the fitted parameters is discussed, and their values are compared with available literature values. UV-vis/near-IR, time-resolved laser-induced fluorescence spectroscopy experiments, and molecular dynamics (MD) calculations were conducted for dilute to concentrated solutions (ca. 3 mol.kg-1) for a study of the microscopic behavior of DyCl3 binary solutions. Coupling MD calculations and extended X-ray absorption fine structure led to the determination of reliable distances. The MD results were used for a discussion of the parameters used in the BIMSA.

  4. Experimental and molecular dynamics studies of dysprosium(III) salt solutions for a better representation of the microscopic features used within the binding mean spherical approximation theory

    Energy Technology Data Exchange (ETDEWEB)

    Ruas, Alexandre; Guilbaud, Philippe; Den Auwer, Christophe; Moulin, Christophe; Simonin, Jean-Pierre; Turq, Pierre; Moisy, Philippe [DEN/DRCP/SCPS, CEA-Valrho Marcoule, BP 17171, 30207 Bagnols-sur-Ceze Cedex, DEN/DPC/SECR/LSRM, CEA-Saclay, Bat 391, BP 91191 Gif sur Yvette, Cedex (France); Laboratoire LI2C (UMR 7612), Universite Pierre et Marie Curie-Paris 6, Boite No. 51, 4 Place Jussieu, 75252 Paris Cedex 05 (France)

    2006-07-01

    This work is aimed at a predictive description of the thermodynamic properties of actinide (III) salt solutions at high concentration and 25 deg. C. A new solution of the binding mean spherical approximation (BIMSA) theory, based on the Wertheim formalism, for taking into account 1: 1 and also 1: 2 complex formation, is used to reproduce, from a simple procedure, experimental osmotic coefficient variation with concentration for three binary salt solutions of the same lanthanide (III) cation: dysprosium (III) perchlorate, nitrate, and chloride. The relevance of the fitted parameters is discussed, and their values are compared with available literature values. UV-vis/near-IR, time-resolved laser-induced fluorescence spectroscopy experiments, and molecular dynamics (MD) calculations were conducted for dilute to concentrated solutions (ca. 3 mol, kg{sup -1}) for a study of the microscopic behavior of DyCl{sub 3} binary solutions. Coupling MD calculations and extended X-ray absorption fine structure led to the determination of reliable distances. The MD results were used for a discussion of the parameters used in the BIMSA. (authors)

  5. Elucidation of Dual Magnetic Relaxation Processes in Dinuclear Dysprosium(III) Phthalocyaninato Triple-Decker Single-Molecule Magnets Depending on the Octacoordination Geometry.

    Science.gov (United States)

    Katoh, Keiichi; Aizawa, Yu; Morita, Takaumi; Breedlove, Brian K; Yamashita, Masahiro

    2017-08-07

    When applying single-molecule magnets (SMMs) to spintronic devices, control of the quantum tunneling of the magnetization (QTM) as well as a spin-lattice interactions are important. Attempts have been made to use not only coordination geometry but also magnetic interactions between SMMs as an exchange bias. In this manuscript, dinuclear dysprosium(III) (Dy(III) ) SMMs with the same octacoordination geometry undergo dual magnetic relaxation processes at low temperature. In the dinuclear Dy(III) phthalocyaninato (Pc(2-) ) triple-decker type complex [(Pc)Dy(ooPc)Dy(Pc)] (1) (ooPc(2-) =2,3,9,10,16,17,23,24-octakis(octyloxy)phthalocyaninato) with a square-antiprismatic (SAP) geometry, the ground state is divided by the Zeeman effect, and level intersection occurs when a magnetic field is applied. Due to the ground state properties of 1, since the Zeeman diagram where the levels intersect in an Hdc of 2500 Oe, two kinds of QTM and direct processes occur. However, dinuclear Dy(III) -Pc systems with C4 geometry, which have a twist angle (ϕ) of less than 45° do not undergo dual magnetic relaxation processes. From magnetic field and temperature dependences, the dual magnetic relaxation processes were clarified. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Annealing behaviour and crystal structure of RF-sputtered Bi-substituted dysprosium iron-garnet films having excess co-sputtered Bi-oxide content

    Energy Technology Data Exchange (ETDEWEB)

    Vasiliev, M; Nur-E-Alam, M; Alameh, K [Electron Science Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027 (Australia); Premchander, P; Lee, Y T [Department of Information and Communications, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712 (Korea, Republic of); Kotov, V A [Institute of Radio Engineering and Electronics, Russian Academy of Sciences, 11 Mohovaya St, Moscow, 125009 (Russian Federation); Lee, Y P, E-mail: m.vasiliev@ecu.edu.au [Quantum Photonic Science Research Center, Department of Physics, Hanyang University, 133-791 (Korea, Republic of)

    2011-02-23

    We investigate the magneto-optic properties, crystal structure and annealing behaviour of nano-composite media with record-high magneto-optic quality exceeding the levels reported so far in sputtered iron-garnet films. Bi-substituted dysprosium-gallium iron-garnet films having excess bismuth oxide content are deposited using RF co-sputtering, and a range of garnet materials are crystallized using conventional oven-annealing processes. We report, for the first time ever, the results of optimization of thermal processing regimes for various high-performance magneto-optic iron-garnet compositions synthesized and describe the evolution of the optical and magneto-optical properties of garnet-Bi-oxide composite-material films occurring during the annealing processes. The crystallization temperature boundaries of the system (BiDy){sub 3}(FeGa){sub 5}O{sub 12} : Bi{sub 2}O{sub 3} are presented. We also report the results of x-ray diffraction and energy-dispersive x-ray spectroscopy studies of this recently developed class of high-performance magneto-optic composites. Our hypothesis of iron oxides being the cause of excess optical absorption in sputtered Bi-iron-garnet films is confirmed experimentally.

  7. Electroweak Radiative Corrections to the Parity-violating Asymmetry for SLAC Experiment E158

    Energy Technology Data Exchange (ETDEWEB)

    Zykunov, Vladimir A.; /Gomel State Tech. U.

    2012-04-04

    Electroweak radiative corrections to observable quantities of Moeller scattering of polarized particles are calculated. We emphasize the contribution induced by infrared divergent parts of cross section. The covariant method is used to remove infrared divergences, so that our results do not involve any unphysical parameters. When applied to the kinematics of SLAC E158 experiment, these corrections reduce the parity violating asymmetry by about -6.5% at E = 48 GeV and y = 0.5, and kinematically weighted 'hard' bremsstrahlung effect for SLAC E158 is {approx} 1%.

  8. Spin-parity assignments and extension of the 02+ band in 158Er

    Directory of Open Access Journals (Sweden)

    Dinoko T S

    2013-12-01

    Full Text Available Low and medium spin collective structures in 158Er have been studied using the 150Sm(12C,4nγγ fusion-evaporation reaction at a beam energy of Elab = 65 MeV. A band built on the 02+ excitation has been established and extended to Jπ = 18+ from the analysis of γ-γ coincidence relationships, intensity arguments and DCO ratios. The 02+ band in 158Er presents a similar trend to the 02+ bands in the lighter N = 90 isotones but lies about 125 keV higher. This systematic trend supports a similar configuration for the 02+ bands in the N = 90 isotones.

  9. Global use structures of the magnetic materials neodymium and dysprosium. A scenario-based analysis of the effect of the diffusion of electromobility on the demand for rare earths; Globale Verwendungsstrukturen der Magnetwerkstoffe Neodym und Dysprosium. Eine szenariobasierte Analyse der Auswirkung der Diffusion der Elektromobilitaet auf den Bedarf an Seltenen Erden

    Energy Technology Data Exchange (ETDEWEB)

    Gloeser-Chahoud, Simon; Kuehn, Andre; Tercero Espinoza, Luis

    2016-06-15

    Neodymium-iron-boron magnets (NdFeB) have experienced a significant demand as the most powerful permanent magnet in recent years, especially for the manufacture of compact electric servomotors with high efficiency and high power density, especially for mobile applications in hybrid traction motors and electric vehicles or for electric bikes. However, NdFeB magnets are also increasingly being used in general mechanical engineering (conveying and pumping systems, tools, air conditioning systems, lift motors, etc.), in the small electric motors of conventional passenger cars or in the generators of large wind power plants with permanent magnetic direct drive. Nevertheless, there is still high uncertainty in the use structures of NdFeB magnets and the contained rare earth elements neodymium and dysprosium. An effective instrument for increasing the market transparency and the understanding of complex anthropogenic material cycles is the dynamic material flow modeling. In the present work paper, this instrument is used for an in-depth analysis of the use structures of NdFeB magnets and the contained rare earths on a global scale. The dynamic modeling of product usage cycles reveals today's usage structures and quantifies future magnetic quantities in obsolete product flows. It could be shown that the magnets in today's scrap volume are mainly contained in obsolete electronics applications such as hard disks (HDD), CD and DVD drives, which makes the recycling hardly seem to be economical due to the small magnets and the high material spread, but in the foreseeable future with larger magnetic quantities from synchronous servomotors and generators can be expected, which significantly increases the recycling potential. In a further step, the effect of the diffusion of alternative drives in the automotive market on the dysprosium requirement is analyzed using a system dynamics model and possible adaptation mechanisms in the form of different substitution effects in

  10. 19 CFR 158.42 - Abandonment by importer within 30 days after entry.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Abandonment by importer within 30 days after entry..., OR EXPORTED Destroyed, Abandoned, or Exported Merchandise § 158.42 Abandonment by importer within 30... which the merchandise being abandoned appears. (b) Application within 30 days. The importer shall...

  11. 24 CFR 200.158 - Applicability of Treasury regulations to debenture transactions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Applicability of Treasury... Mortgage Insurance Procedures and Processing Claims for Losses § 200.158 Applicability of Treasury regulations to debenture transactions. The Department of the Treasury acts as fiscal agent for...

  12. $\\psi^'$ production in Pb-Pb collisions at 158 GeV/nucleon

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Castor, J; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Comets, M P; Constantinescu, S; Cortese, P; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Fargeix, J; Force, P; Gallio, M; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Idzik, M; Jouan, D; Karavicheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scomparin, E; Serci, S; Shahoyan, R; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, E; Villatte, L; Willis, N

    2007-01-01

    \\psi^' production is studied in Pb-Pb collisions at 158 GeV/c per nucleon incident momentum. Absolute cross-sections are measured and production rates are investigated as a function of the centrality of the collision. The results are compared with those obtained for lighter colliding systems and also for the J/\\psi meson produced under identical conditions.

  13. 40 CFR 81.158 - Southern Wisconsin Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Air Quality Control Regions § 81.158 Southern Wisconsin Intrastate Air Quality Control Region. The Southern Wisconsin Intrastate Air Quality Control Region consists of the territorial area encompassed by... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Southern Wisconsin Intrastate...

  14. 77 FR 19002 - Foreign-Trade Zone 158-Vicksburg/Jackson, MS; Application for Expansion

    Science.gov (United States)

    2012-03-29

    ... Order 430, 54 FR 15480, 4/18/89), and expanded on October 23, 1994 (Board Order 707, 59 FR 54885, 11/2/94), and on March 8, 2005 (Board Order 1378, 70 FR 13449, 3/21/05). The zone currently consists of 17... Foreign-Trade Zones Board Foreign-Trade Zone 158--Vicksburg/Jackson, MS; Application for Expansion...

  15. 40 CFR 158.2040 - Biochemical pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pheromones), natural and plant growth regulators. Notes that apply to an individual test and include specific... for biochemical agents in the biochemical human health assessment data requirements, § 158.2050. 2.... Required unless it is an arthropod pheromone applied at a rate less than or equal to 150 grams...

  16. 40 CFR 158.2082 - Experimental use permit biochemical pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... and attractants, semiochemicals (e.g., insect pheromones), natural and plant growth regulators. Notes... biochemical agents in the biochemical human health assessment data requirements, § 158.2050. 2. The same... an arthropod pheromone applied at a rate less than or equal to 150 grams active ingredient per...

  17. 40 CFR 158.2070 - Biochemical pesticides product performance data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides product... AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2070 Biochemical pesticides product performance data requirements. Product performance data must be developed...

  18. 40 CFR 158.2160 - Microbial pesticides product performance data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides product... AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2160 Microbial pesticides product performance data requirements. Product performance data must be developed...

  19. COMT Val158Met Genotype as a Risk Factor for Problem Behaviors in Youth

    Science.gov (United States)

    Albaugh, Matthew D.; Harder, Valerie S.; Althoff, Robert R.; Rettew, David C.; Ehli, Erik A.; Lengyel-Nelson, Timea; Davies, Gareth E.; Ayer, Lynsay; Sulman, Julie; Stanger, Catherine; Hudziak, James J.

    2010-01-01

    Objective: To test the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and both aggressive behavior and attention problems in youth. We hypothesized that youth carrying a Met allele would have greater average aggressive behavior scores, and that youth exhibiting Val-homozygosity would have greater average…

  20. 40 CFR 158.2030 - Biochemical pesticides product chemistry data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides product... PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2030 Biochemical pesticides product chemistry data requirements table. (a) General. (1) Sections...

  1. 37 CFR 1.58 - Chemical and mathematical formulae and tables.

    Science.gov (United States)

    2010-07-01

    ... Provisions The Application § 1.58 Chemical and mathematical formulae and tables. (a) The specification, including the claims, may contain chemical and mathematical formulae, but shall not contain drawings or flow... mathematical formulae must be encoded to maintain the proper positioning of their characters when displayed...

  2. 42 CFR 483.158 - FFP for nurse aide training and competency evaluation.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false FFP for nurse aide training and competency... Competency Evaluation, and Paid Feeding Assistants § 483.158 FFP for nurse aide training and competency evaluation. (a) State expenditures for nurse aide training and competency evaluation programs and...

  3. Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Somatosensory Amplification and Nocebo Responses

    Science.gov (United States)

    Benson, Sven; Engler, Harald; Engler, Andrea; Hinney, Anke; Rief, Winfried; Witzke, Oliver; Schedlowski, Manfred

    2014-01-01

    A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups. These nocebo effects also play a major role in drug discontinuation in clinical practice, negatively affecting treatment efficacy as well as patient adherence and compliance. Experimental and clinical data document a large interindividual variability in nocebo responses, however, data on psychological, biological or genetic predictors of nocebo responses are lacking. Thus, with an established paradigm of behaviorally conditioned immunosuppressive effects we analyzed possible genetic predictors for nocebo responses. We focused on the genetic polymorphisms in the catechol-O-methyltransferase (COMT) gene (Val158Met) and analyzed drug specific and general side effects before and after immunosuppressive medication and subsequent placebo intake in 62 healthy male subjects. Significantly more drug-specific as well as general side effects were reported from homozygous carriers of the Val158 variant during medication as well as placebo treatment compared to the other genotype groups. Val158/Val158 carriers also had significantly higher scores in the somatosensory amplification scale (SSAS) and the BMQ (beliefs about medicine questionnaire). Together these data demonstrate potential genetic and psychological variables predicting nocebo responses after drug and placebo intake, which might be utilized to minimize nocebo effects in clinical trials and medical practice. PMID:25222607

  4. COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia

    DEFF Research Database (Denmark)

    Haraldsson, H Magnus; Ettinger, Ulrich; Magnusdottir, Brynja B;

    2009-01-01

    The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls...

  5. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses.

    Directory of Open Access Journals (Sweden)

    Laura Wendt

    Full Text Available A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups. These nocebo effects also play a major role in drug discontinuation in clinical practice, negatively affecting treatment efficacy as well as patient adherence and compliance. Experimental and clinical data document a large interindividual variability in nocebo responses, however, data on psychological, biological or genetic predictors of nocebo responses are lacking. Thus, with an established paradigm of behaviorally conditioned immunosuppressive effects we analyzed possible genetic predictors for nocebo responses. We focused on the genetic polymorphisms in the catechol-O-methyltransferase (COMT gene (Val158Met and analyzed drug specific and general side effects before and after immunosuppressive medication and subsequent placebo intake in 62 healthy male subjects. Significantly more drug-specific as well as general side effects were reported from homozygous carriers of the Val158 variant during medication as well as placebo treatment compared to the other genotype groups. Val158/Val158 carriers also had significantly higher scores in the somatosensory amplification scale (SSAS and the BMQ (beliefs about medicine questionnaire. Together these data demonstrate potential genetic and psychological variables predicting nocebo responses after drug and placebo intake, which might be utilized to minimize nocebo effects in clinical trials and medical practice.

  6. 40 CFR 158.1050 - Post-application exposure-general requirements.

    Science.gov (United States)

    2010-07-01

    ...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Human Exposure § 158.1050 Post-application exposure... requirements if the data meet the basic quality assurance, quality control, good laboratory practice, and other scientific needs of EPA. In order to be acceptable, among other things, the Agency must find that the...

  7. Pathologic and clinical analysis on 158 cases of renal biopsy%158例肾活检病理及临床分析

    Institute of Scientific and Technical Information of China (English)

    畅飞; 张莉; 孟梅霞; 安军民; 高明; 傅艳平

    2012-01-01

    目的 回顾性总结158例肾活检的病理结果,分析其病理类型及临床分类特点.方法 总结我院158例肾活检病理资料,分析其病理类型与临床分类特点.结果 158例肾活检中原发性肾小球疾病125例(79.11%),继发性肾小球疾病33例(20.89%).原发性肾小球疾病病理类型最多的是系膜增生型肾炎,第二位是IgA肾病,继发性肾小球疾病以紫癜性肾炎病理类型最多.原发性肾小球疾病临床分布最多的前三位依次是肾病综合征、慢性肾炎、IgA肾病.其中肾病综合征的病理类型主要是系膜增生型和膜性肾病,慢性肾炎的主要病理类型是系膜增生型和肾小球硬化.结论 原发性肾小球疾病是最常见的肾小球疾病,肾活检病理类型以系膜增生型肾炎、IgA肾病最多,临床类型则以肾病综合征、慢性肾炎、IgA肾病最为多见.%Objective To retrospectively summarize the pathological results of 158 cases of renal biopsy, and to analyze the pathological types and clinical classification. Methods The pathological data of 158 cases of renal biopsy were pathology retrospectively analyzed. Results Among the 158 cases, 125 cases (79.11%) were of primary glomerular disease and 33 cases (20.89%) were of secondary glomerular diseases. The most common pathological type of primary glomerular disease was mesangial proliferative glomerulonephritis, the second was IgA nephropathy. The most common pathological type of secondary glomerular diseases was purpura nephritis. The top three primary glomerular diseases with most clinical distribution were nephrotic syndrome, chronic nephritis, IgA nephropathy. The main pathological types of nephrotic syndrome were mesangial proliferative and membranous nephropathy, and the main types of chronic nephritis was mesangial proliferative and glomerular sclerosis. Conclusion Primary glomerular disease is the most common renal disease occurred in China. The most common pathological types of

  8. Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease.

    Science.gov (United States)

    Zhang, Youwen; Feng, Shujun; Nie, Kun; Zhao, Xin; Gan, Rong; Wang, Limin; Zhao, Jiehao; Tang, Hongmei; Gao, Liang; Zhu, Ruiming; Wang, Lijuan; Zhang, Yuhu

    2016-10-15

    The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to be associated with increased risk of Parkinson's disease (PD) and have a specific impact on dopamine-mediated prefrontal executive function in an inverted-U curve manner. We explored the influence of this genetic polymorphism on prefrontal executive function in a well-established Chinese cohort of early PD patients with no current or past history of motor fluctuations or dyskinesias. Cognitive functions were assessed in 250 patients with early PD using Wechsler Adult Intelligence Scale-Chinese Revision (WAIS-RC) and Wechsler Memory Scale-Chinese Revision (WMS-RC). These patients and 300 healthy controls were subsequently genotyped for the COMT gene Val158Met polymorphism. We employed analysis of covariance (ANCOVA) and a stratified analysis to determine the associations between the COMT Val158Met genotype and cognitive functions. The COMT Val158Met allele frequency and genotype distributions showed no statistically significant differences between PD patients and controls. However, patients with met/met genotype performed significantly worse on WAIS-RC similarities, a measure of executive function, compared to individuals with val/val genotype. Subsequent ANCOVA analysis revealed that COMT genotype interacted with sex and daily levodopa equivalent dose (LED) to influence executive function. Further stratified analysis showed that the lower-activity COMT met/met genotype has a detrimental effect on executive function among women. Our results demonstrate that COMT Val158Met polymorphism is probably not associated with increased risk of PD, but has an effect on prefrontal executive function interacting with gender and dopaminergic medication. Copyright © 2016. Published by Elsevier B.V.

  9. 158株金黄色葡萄球菌耐药性分析%Analysis of drug resisitance in 158 strains of Staphylococcus aureus

    Institute of Scientific and Technical Information of China (English)

    武超; 晏开力; 戴媛媛

    2012-01-01

    目的 了解住院患者感染的金黄色葡萄球菌(methicillin sensitive staphylococcus aureus,MSSA)对常用抗生素的耐药情况,以指导临床合理使用抗生素.方法 应用VITEK32微生物自动鉴定分析系统,采用K-B法对2009-03至2011-10临床各科室分离的158株MSSA进行药物敏感性试验,并对其药敏结果 进行统计分析.结果 158株MSSA中耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)96株,占60.76%,对青霉素G、氨苄西林100%耐药,对万古霉素100%敏感;对甲氧西林敏感MSSA,占39.24%,对青霉素G、氨苄西林耐药率分别为69.35%和67.74%,对利奈唑胺、喹努普汀/达福普汀和万古霉素100%敏感.结论 MSSA是临床感染的主要病原菌之一,分析MSSA耐药情况,可以指导临床合理选用抗生素.%Objective To study the resistance of clinically - isolated Staphylococcus aureus to antimicrobial agents so as to facilitate the rational use of antibiotics. Methods The pathogenic bacteria were evaluated by VITEK32. Drug susceptibility test was carried out by K - B method. The results of 158 strains of Staphylococcus aureus were analysed by WHONET. Results 96 strains of MR-SA were detected from 158 strains of Staphylococcus aureus, which accounted for 60.76% . All the MRSA was resistant to penicillin and ampicillin but was sensitive to vancomycin. The resistance rate of MSSA to penicillin and ampicillin was 69.35% and 67.74% , respectively, and all the MSSA was sensitive to linezolid, quinupristin/dalfopristin and vancomycin. Conclusions Staphylococcus aureus is one of the main pathogens of clinical infection. Analysis of drug resistance of Staphylococcus aureus can guide the clinical use of antibiotics.

  10. The role of dysprosium on the structural and magnetic properties of (Nd1-xDyx)2Fe14B nanoparticles

    Science.gov (United States)

    Rahimi, Hamed; Ghasemi, Ali; Mozaffarinia, Reza; Tavoosi, Majid

    2017-02-01

    In current work, Nd2Fe14B nanoparticles was synthesized by sol-gel method. Dysprosium powders were added into Nd2Fe14B nanoparticles by mechanical alloying process in order to enhancement of coercivity. The phase analysis, structure, and magnetic properties of annealed (Nd1-xDyx)2Fe14B nanoparticles with different Dy-content (x=0.1, 0.2, 0.3, 0.4, 0.5, 0.6) were investigated by employing X-ray diffraction, X-ray photoelectron spectroscopy, energy dispersive spectroscopy, field emission scanning electron microscope, transmission electron microscope and vibrating sample magnetometer techniques. The results showed that with an increase in Dy amounts, the coercivity of particles increased from 2.9 kOe to 13.4 kOe and then decreased to 5.6 kOe. By adding an optimum amount of Dy (x=0.4), the coercivity was significantly increased from 2.9 kOe to 13.4 kOe. The average particle size of annealed (Nd1-xDyx)2Fe14B nanoparticles was below 10 nm. Magnetization reversal studies indicate that the coercivity of milled and annealed (Nd1-xDyx)2Fe14B nanoparticles is controlled by the nucleation of reversed magnetic domains. The experimental results in the angular dependence of coercivity for (Nd1-xDyx)2Fe14B permanent magnets showed that the normalized coercivity of the permanent magnets Hc(θ)/Hc(0) increases from 1 to about 1.2-1.5 with increasing θ from 0 to about π/3, for x=0.4-0.6.

  11. Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility.

    LENUS (Irish Health Repository)

    McGrath, Emma

    2012-02-01

    PROBLEM: Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility. METHOD OF STUDY: NK cell phenotypes were determined by flow cytometry in endometrial biopsies and matched blood samples. RESULTS: While circulating and endometrial T cell populations remained constant throughout the menstrual cycle in fertile and infertile women, circulating NK cells in infertile women increased during the secretory phase. However, increased expression of CD94, CD158b (secretory phase), and CD158a (proliferative phase) by endometrial NK cells from infertile women was observed. These changes were not reflected in the circulation. CONCLUSION: In infertile women, changes in circulating NK cell percentages are found exclusively during the secretory phase and not in endometrium; cycle-related changes in NK receptor expression are observed only in infertile endometrium. While having exciting implications for understanding NK cell function in fertility, our data emphasize the difficulty in attaching diagnostic or prognostic significance to NK cell analyses in individual patients.

  12. Precise measurement in elastic electron scattering: HAPPEX and E-158 experiments; Mesures precises de violation de parite en diffusion d'electrons: experiences HAPPEX et E-158

    Energy Technology Data Exchange (ETDEWEB)

    Vacheret, A

    2004-12-01

    Parity Violation asymmetry measurements in elastic electron scattering are in one hand an interesting way of retrieving new informations about the sea quarks of the nucleon and in the other hand a powerful test of the Standard Model electroweak sector at low energy. This thesis describes the HAPPEX experiment at JLab and the E-158 experiment at SLAC (USA) which measure de parity violation asymmetries in elastic scattering of polarized electron on nuclei like Hydrogen or Helium and on atomic electrons. With the measurements on hadronic targets one can extract the strange quarks contribution to the charge and current density of the nucleon. With the electron-electron scattering one can test the standard model at the loop level and far from the Z pole by extracting sin{sup 2} {theta}{sub W}. In this thesis we describe the formalism associated with the electroweak probe. We present in detail the experimental methods used to make such precise measurements of parity violation asymmetry. Then, we describe the experimental set-up of each experiment and in particular the electron detector and the feedback loop on the beam current for the HAPPEX experiment and the analysis of E-158 run III with a dedicated systematic study on the beam sub-pulse fluctuations. We present the preliminary results for each experiment with a comparison with the other existing results and the future experiments. (author)

  13. P158

    Directory of Open Access Journals (Sweden)

    N. Dementyeva

    2015-11-01

    Work was conducted with the application of the Tomsk regional common use center technical equipment acquired thanks to a grant of the Russian Ministry of the Agreement No. 14.594.21.0001 (RFMEFI59414X0001. This project is supported by “The Tomsk State University Academic D.I. Mendeleev Fund Program” under Grant (No. 18.1.52.2015.

  14. Association study between COMT 158Met and creativity scores in bipolar disorder and healthy controls

    OpenAIRE

    2014-01-01

    Background Bipolar disorder (BD) patients have been reported to be associated higher creativity abilities, and recent data tend to support the hypothesis that dopaminergic system that could be associated with creativity. Catechol-O-methyltransferase (COMT) is one of the major enzymes involved in the metabolic degradation of dopamine. The COMT gene polymorphism (rs4680 or Val158Met) Met allele is reported to cause decreased activity of this enzyme in prefrontal cortex and improve performance ...

  15. Directed and Elliptic Flow in 158 GeV/Nucleon Pb + Pb Collisions

    CERN Document Server

    Appelshäuser, H; Bailey, S J; Barnby, L S; Bartke, J; Barton, R A; Bialkowska, H; Blyth, C O; Bock, R; Bormann, C; Brady, F P; Brockmann, R; Buncic, N; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Dunn, J; Eckardt, V; Eckardt, F; Ferguson, M I; Fischer, H G; Flier, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Fuchs, M; Gabler, F; Gál, J; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Petridis, A; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Rendfort, R; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sandoval, A; Sann, H; Semenov, A Yu; Schäfer, E; Scjmischke, D; Schmitz, N; Schönfelder, S; Seyboth, P; Seyerlein, J; Siklér, F; Skrzypczak, E; Squier, G T A; Stock, R; Ströbele, H; Szentpétery, I; Sziklay, J; Toy, M; Trainor, T A; Trentalage, S; Ullrich, T; Vassiliou, M; Veztergombi, G; Voloshin, S; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wienold, T; Wood, L; Yates, T A; Zimányi, J; Zybert, R

    1998-01-01

    The directed and elliptic flow of protons and charged pions has been observed from the semi-central collisions of a 158 GeV/nucleon Pb beam with a Pb target. The rapidity and transverse momentum dependence of the flow has been measured. The directed flow of the pions is opposite to that of the protons but both exhibit negative flow at low pt. The elliptic flow of both is fairly independent of rapidity but rises with pt.

  16. Multifractal moments in heavy ion Pb-Pb collisions at 158 A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Dutt, Sunil [Department of Physics, Govt. College for Women GandhiNagar, Jammu - J& K (India)

    2016-05-06

    In present work, we use the method of scaled factorial moments to search for intermittent behavior in Pb-Pb interactions at 158 A GeV. The analysis is done on photon distributions obtained using preshower photon multiplicity detector. Scaled factorial moments are used to study short range fluctuations in pseudorapidity distributions of photons. Scaled factorial moments are calculated using horizontal corrected and vertical analysis. The results are compared with simulation analysis using VENUS event generator.

  17. Metabolic Studies on WR-158,122 in Bile Duct Cannulated Rats and Monkeys.

    Science.gov (United States)

    1980-02-15

    usually be counted directly, but some highly- colored samples may require bleaching. 5. Feces. Feces are digested in appropriately sized jars with 10 volumes...sulfate, niacin supplement, calcium O. pantothenate, copper sulfate, vitamin B12 supplement, vitamin D3 supplement, manganese sulfate, riboflavin ...after recording color and volume of each phase and salt, if any. 0 47 Table 3.2 Extraction of Control Monkey Urine Spiked with WR-158,122 14C Solvent

  18. Predisposing Factors of Complicated Deep Neck Infection: An Analysis of 158 Cases

    OpenAIRE

    Lee, Joon-Kyoo; Kim, Hee-Dae; Lim, Sang-Chul

    2007-01-01

    Both the introduction of antibiotics and improvements in oral hygiene have made deep neck infections occur less frequently today than in the past. Nevertheless, the complications from these infections are often life-threatening. The purpose of this article was to review the clinical findings of deep neck infections and identify the predisposing factors of these complications. The present study reviewed 158 cases of deep neck infections between the years of 1995 to 2004, 23 of which had life-t...

  19. Multiplicity fluctuations in nuclear collisions at 158A GeV

    CERN Document Server

    Rybczynski, Maciej; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Trubnikov, V; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Van Leeuwen, M; 10.1088/1742-6596/5/1/007

    2005-01-01

    The system size dependence of multiplicity fluctuations of charged particles produced in nuclear collisions at 158A GeV was studied in the NA49 CERN experiment. The results indicate a non-monotonic dependence of the scaled variance of the multiplicity distribution with a maximum for semi-peripheral Pb+Pb interactions with number of projectile participants of about 35. This effect is not observed in a string-hadronic model of nuclear collision HIJING.

  20. Antinuclei production in Pb + Pb collisions at 158 A GeV/ c

    Science.gov (United States)

    Appelquist, G.; Baglin, C.; Beringer, J.; Bohm, C.; Borer, K.; Bussière, A.; Dittus, F.; Elsener, K.; Frei, D.; Gorodetzky, Ph.; Guillaud, J. P.; Hugentobler, E.; Klingenberg, R.; Linden, T.; Lohmann, K. D.; Moser, U.; Pal, T.; Pretzl, K.; Schacher, J.; Selldén, B.; Stoffel, F.; Tuominiemi, J.; Zhang, Q. P.; Newmass (NA52) Collaboration

    1996-02-01

    We investigate antinuclei production in Pb + Pb interactions at 158 GeV/ c per nucleon at zero degree production angle. We quote invariant differential production cross sections for antiprotons and antideuterons. The corresponding antideuteron to antiproton ratio at midrapidity is 4.2 · 10 -4. One antihelium-3 nucleus was observed. The results are discussed in the framework of a simple coalescence model.

  1. BMP-Smad 1/5/8 signalling in the development of the nervous system.

    Science.gov (United States)

    Hegarty, Shane V; O'Keeffe, Gerard W; Sullivan, Aideen M

    2013-10-01

    The transcription factors, Smad1, Smad5 and Smad8, are the pivotal intracellular effectors of the bone morphogenetic protein (BMP) family of proteins. BMPs and their receptors are expressed in the nervous system (NS) throughout its development. This review focuses on the actions of Smad 1/5/8 in the developing NS. The mechanisms by which these Smad proteins regulate the induction of the neuroectoderm, the central nervous system (CNS) primordium, and finally the neural crest, which gives rise to the peripheral nervous system (PNS), are reviewed herein. We describe how, following neural tube closure, the most dorsal aspect of the tube becomes a signalling centre for BMPs, which directs the pattern of the development of the dorsal spinal cord (SC), through the action of Smad1, Smad5 and Smad8. The direct effects of Smad 1/5/8 signalling on the development of neuronal and non-neuronal cells from various neural progenitor cell populations are then described. Finally, this review discusses the neurodevelopmental abnormalities associated with the knockdown of Smad 1/5/8.

  2. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome.

    Directory of Open Access Journals (Sweden)

    Kathryn T Hall

    Full Text Available Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT, an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS. The three treatment arms from this study were: no-treatment ("waitlist", placebo treatment alone ("limited" and, placebo treatment "augmented" with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035. The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response.

  3. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome.

    Science.gov (United States)

    Hall, Kathryn T; Lembo, Anthony J; Kirsch, Irving; Ziogas, Dimitrios C; Douaiher, Jeffrey; Jensen, Karin B; Conboy, Lisa A; Kelley, John M; Kokkotou, Efi; Kaptchuk, Ted J

    2012-01-01

    Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS). The three treatment arms from this study were: no-treatment ("waitlist"), placebo treatment alone ("limited") and, placebo treatment "augmented" with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS) after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response.

  4. Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome

    Science.gov (United States)

    Hall, Kathryn T.; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin B.; Conboy, Lisa A.; Kelley, John M.; Kokkotou, Efi; Kaptchuk, Ted J.

    2012-01-01

    Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS). The three treatment arms from this study were: no-treatment (“waitlist”), placebo treatment alone (“limited”) and, placebo treatment “augmented” with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS) after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response. PMID:23110189

  5. COMT Val108/158 Met Genotype Affects Neural but not Cognitive Processing in Healthy Individuals

    Science.gov (United States)

    Need, Anna C.; LaBar, Kevin S.; Waters-Metenier, Sheena; Cirulli, Elizabeth T.; Kragel, James; Goldstein, David B.; Cabeza, Roberto

    2010-01-01

    The relationship between cognition and a functional polymorphism in the catechol-O-methlytransferase (COMT) gene, val108/158met, is one of debate in the literature. Furthermore, based on the dopaminergic differences associated with the COMT val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. To investigate these issues the current study aimed to 1) examine the effects of COMT genotype using a large sample of healthy individuals (n = 496–1218) and multiple cognitive measures, and using a subset of the sample (n = 22), 2) examine whether COMT genotype effects medial temporal lobe (MTL) and frontal activity during successful relational memory processing, and 3) investigate group differences in functional connectivity associated with successful relational memory processing. Results revealed no significant group difference in cognitive performance between COMT genotypes in any of the 19 cognitive measures. However, in the subset sample, COMT val homozygotes exhibited significantly decreased MTL and increased prefrontal activity during both successful relational encoding and retrieval, and reduced connectivity between these regions compared with met homozygotes. Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output. PMID:19641018

  6. Dysprosium(III) complexes with a square-antiprism configuration featuring mononuclear single-molecule magnetic behaviours based on different β-diketonate ligands and auxiliary ligands.

    Science.gov (United States)

    Zhang, Sheng; Ke, Hongshan; Shi, Quan; Zhang, Jangwei; Yang, Qi; Wei, Qing; Xie, Gang; Wang, Wenyuan; Yang, Desuo; Chen, Sanping

    2016-03-28

    Three mononuclear dysprosium(III) complexes derived from three β-diketonate ligands, 4,4,4-trifluoro-1-(4-methylphenyl)-1,3-butanedione (tfmb), 4,4,4-trifluoro-1-(4-fluorophenyl)-1,3-butanedione (tffb) and 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedione (tfnb) as well as auxiliary ligands, 5-nitro-1,10-phenanthroline (5-NO2-Phen), DMF and 2,2'-bipyridine (bpy) have been synthesized and structurally characterized, namely [Dy(5-NO2-Phen)(tfmb)3] (1), [Dy(DMF)2(tffb)3] (2) and [Dy(bpy)2(tfnb)3]·0.5(1,4-dioxane) (3). The metal ions in 1-3 adopt an approximately square-antiprismatic (SAP) coordination environment with D4d axial symmetry. The magnetic properties of 1-3 have been investigated, displaying weak out-of-phase AC signals under a zero-DC field. With an applied DC field of 1200 Oe, the quantum tunnelling of the magnetization was suppressed in 1-3 with the pre-exponential factor τ0 = 5.3 × 10(-7) s and the effective barrier ΔE/kB = 83 K for 1 as well as the pre-exponential factor τ0 = 3.09 × 10(-7) s and the effective barrier ΔE/kB = 39 K for 3. Interestingly, for the frequency dependence of the out-of-phase (χ'') of the AC susceptibility of 2, two slow relaxation of the magnetization processes occurred under the applied magnetic field of 1200 Oe, corresponding to the fast relaxation (FR) phase and slow relaxation (SR) phase, respectively. Arrhenius analysis gave the effective energy barrier (ΔE/kB) of 55 K and the pre-exponential factor (τ0) of 8.23 × 10(-12) for the SR. It is thus very likely that the FR process in complex 2 results from QTM enhanced by dipolar interactions between the Dy ions or the presence of the applied field. The structure-property relationship of some Dy(III) based mononuclear SMMs with the SAP configuration was further discussed.

  7. Magnetic Phase Transition of Nanocrystalline Bulk Metal Gadolinium and Dysprosium%纳米块体金属钆和镝的磁性相变分析

    Institute of Scientific and Technical Information of China (English)

    刘凤艳; 侯碧辉; 岳明; 王克军

    2011-01-01

    The magnetic properties of bulk nanocrystalline metal gadolinium (Gd) and dysprosium (Dy)samples were studied.The magnetization and Curie temperature TC of nanocrystalline Gd and Dy decreased usually as compared with the polycrystal.However,when the mean grain size was 10 nm, the Curie temperature Tc of nanocrystalline Dy increased to 100 K instead and there was an antiferromagnetic phase in nanocrystalline Gd.According to the calculation based on Ruderman-Kittel-Kasuya-Yosida exchange interaction, the exchange integral of the grain boundary atoms and crystalline surface atoms had its sign changed from plus to minus or vice versa, and there were three orderly phases in the steady state with the lowest energy, ferromagnetic phase, antiferromagnetic phase and fan phase.For the nanocrystals with mean grain size of 10 nm, the proportion of grain boundary to crystalline surface atoms was high, and as the result of superposition of the three phases, and there appeared a peak near the phase transition temperature for the nanocrystalline Gd.While for the Dy, the magnetization decreased gently with temperature, and showing a higher Curie temperature than in the case of the polycrystal.%对纳米晶钆(Gd)和镝(Dy)块体材料的磁性进行了研究.与多晶比较,通常纳米晶的磁化强度减小,居里温度TC降低,但平均粒径为10 nm的纳米晶Dy的居里温度TC反而升高到100 K,平均粒径为10 nm的纳米晶Gd中还存在明显的反铁磁相.通过RKKY交换作用的计算知道,晶面晶界处原子的交换积分会发生正负号的变化,能量最低的稳定状态对应三种有序相:铁磁相、反铁磁相和扇相,晶粒中在一定条件下出现三相共存.对于平均粒径为10 nm的纳米晶,晶面晶界处原子所占比例很大,三相叠加的结果,对于Gd,即是在相变点附近出现磁化强度尖峰;对于Dy,则是磁化强度随温度升高下降缓慢,表现为居里温度TC比多晶升高.

  8. No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population

    Directory of Open Access Journals (Sweden)

    Bassam Lajin

    2011-01-01

    Full Text Available Background : The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. Aims: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. Methods and Materials: 71 unrelated schizophrenic subjects (45 men and 102 unrelated healthy controls (62 men were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. Results: the results demonstrated that there is no statistically significant difference between the two groups. Conclusion: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.

  9. Association between the catechol-o-methyltransferase val158met polymorphism with susceptibility and severity of carpal tunnel syndrome

    Directory of Open Access Journals (Sweden)

    Erkol İnal E

    2015-12-01

    Full Text Available Carpal tunnel syndrome (CTS is the most common entrapment neuropathy of the upper extremity. In this study, we aimed to clarify the relationships between the catechol-O-methyltransferase (COMT gene Val158Met (rs4680 polymorphism and development, functional and clinical status of CTS. Ninety-five women with electro diagnostically confirmed CTS and 95 healthy controls were enrolled in the study. The functional and clinical status of the patients was measured by the Turkish version of the Boston Questionnaire and intensity of pain related to the past 2 weeks was evaluated on a visual analog scale (VAS. The Val158Met polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP, method. We divided patients according to the genotypes of the Val158Met polymorphism as Val/Val, Val/Met and Met/Met. There were not any significant differences in terms of Val158Met polymorphisms between patients and healthy controls (p >0.05. We also did not find any relationships between the Val158Met polymorphism and CTS (p >0.05. In conclusion, although we did not find any relationships between CTS and the Val158Met polymorphism, we could not generalize this result to the general population. Future studies are warranted to conclude precise associations.

  10. Mid-Rapidity Protons in 158A$\\cdot$GeV Pb + Pb Collisions

    CERN Document Server

    Bearden, I G; Boissevain, J G; Dodd, J; Erazmus, B; Esumi, S C; Fabjan, Christian Wolfgang; Ferenc, D; Fields, D E; Franz, A; Gaardhøje, J J; Hansen, O; Hardtke, D; van Hecke, H; Holzer, E B; Humanic, T J; Hummel, P; Jacak, B V; Jayanti, R; Kaneta, M; Kopytine, M L; Leltchouk, M; Ljubicic, T; Lörstad, B; Maeda, N; Medvedev, A; Murray, M; Nishimura, S; Ohnishi, H; Paic, G; Pandey, S U; Piuz, François; Pluta, F; Polychronakos, V; Potekhin, M V; Poulard, G; Sakaguchi, A; Simon-Gillo, J; Schmidt-Sørensen, J; Sondheim, W E; Spegel, M; Sugitate, T; Sullivan, J P; Sumi, Y; Willis, W J; Wolf, K; Xu, N; Zachary, D S

    1996-01-01

    Proton distributions at mid-rapidity (2 $\\le y \\le$ 3) have been measured for 158A$\\cdot$GeV Pb + Pb collisions in the focusing spectrometer experiment NA44 at CERN. From baryon number conservation and by comparing the experimentally measured dN/dy distribution with the transport model RQMD, we conclude that a rather high degree of nuclear stopping has been reached for the truly heavy-ion collisions at these energies. Transverse mass distributions exhibit characteristically thermal shapes and the slope parameters increase with the mass of the colliding system.

  11. Transverse Momentum Fluctuations in Nuclear Collisions at 158 AGeV

    CERN Document Server

    Anticic, T.; Barna, D.; Bartke, J.; Behler, M.; Betev, L.; Bialkowska, H.; Billmeier, A.; Blume, C.; Boimska, B.; Botje, M.; Bracinik, J.; Bramm, R.; Brun, R.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chvala, O.; Cramer, J.G.; Csato, P.; Darmenov, N.; Dimitrov, A.; Dinkelaker, P.; Eckardt, V.; Filip, P.; Flierl, D.; Fodor, Z.; Foka, P.; Freund, P.; Friese, V.; Gal, J.; Gazdzicki, M.; Georgopoulos, G.; Gladysz, E.; Hegyi, S.; Hohne, C.; Kadija, K.; Karev, A.; Kolesnikov, V.I.; Kollegger, T.; Korus, R.; Kowalski, M.; Kraus, I.; Kreps, M.; van Leeuwen, M.; Levai, P.; Litov, L.; Makariev, M.; Malakhov, A.I.; Markert, C.; Mateev, M.; Mayes, B.W.; Melkumov, G.L.; Meurer, C.; Mischke, A.; Mitrovski, M.; Molnar, J.; Mrowczynski, S.; Palla, G.; Panagiotou, A.D.; Panayotov, D.; Perl, K.; Petridis, A.; Pikna, M.; Pinsky, Lawrence S.; Puhlhofer, F.; Reid, J.G.; Renfordt, R.; Retyk, W.; Roland, C.; Roland, G.; Rybczynski, M.; Rybicki, A.; Sandoval, A.; Sann, H.; Schmitz, N.; Seyboth, P.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Stefanek, G.; Stock, R.; Strobele, H.; Susa, T.; Szentpetery, I.; Sziklai, J.; Trainor, T.A.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wetzler, A.; Wlodarczyk, Z.; Yoo, I.K.; Zaranek, J.; Zimanyi, J.

    2004-01-01

    Results are presented on event-by-event fluctuations in transverse momentum of charged particles, produced at forward rapidities in p+p, C+C, Si+Si and Pb+Pb collisions at 158 AGeV. Three different characteristics are discussed: the average transverse momentum of the event, the Phi_pT fluctuation measure and two-particle transverse momentum correlations. In the kinematic region explored, the dynamical fluctuations are found to be small. However, a significant system size dependence of Phi_pT is observed, with the largest value measured in peripheral Pb+Pb interactions. The data are compared with predictions of several models.

  12. Particle production in central Pb+Pb collisions at 158A GeV/c

    CERN Document Server

    Bearden, I G; Boissevain, J G; Christiansen, P H L; Conin, L; Dodd, J; Erazmus, B; Esumi, S; Fabjan, Christian Wolfgang; Ferenc, D; Fields, D E; Franz, A; Gaardhøje, J J; Hamelin, M; Hansen, A G; Hansen, O; Hardtke, D; Holzer, E B; Humanic, T J; Hummel, P; Jacak, B V; Kaimi, K; Kaneta,1 M; Kohama, T; Kopytine, M; Leltchouk, M; Ljubicic, A; Lörstad, B; Maeda, N; Malina, R; Martin, L; Medvedev, A; Murray, M; Ohnishi, H; Paic, G; Pandey, S U; Piuz, François; Pluta, J; Polychronakos, V; Potekhin, M V; Poulard, G; Reichhold, D M; Sakaguchi, A; Schmidt-Sørensen, J; Simon-Gillo, J; Sondheim, W E; Spegel, M; Sugitate, T; Sullivan, J P; Sumi, Y; Willis, W J; Wolf, K L; Xu, N; Zachary, D S; van Hecke, H; Ljubicic, A Jr

    2002-01-01

    The NA44 experiment has measured single-particle inclusive spectra for charged pions, kaons, and protons as a function of transverse mass near midrapidity in 158A GeV/c Pb+Pb collisions. From the particle mass dependence of the observed m/sub T/ distributions, we are able to deduce a value of about 120 MeV for the temperature at thermal freeze-out. From the observed ratios of the rapidity densities, we find values of the chemical potentials for light and strange quarks and a chemical freeze-out temperature of approximately 140 MeV. (34 refs).

  13. Two-proton correlations from 158 A GeV Pb + Pb central collisions

    CERN Document Server

    Appelshauser, H.; Bailey, S.J.; Barna, D.; Barnby, L.S.; Bartke, J.; Barton, R.A.; Betev, L.; Bialkowska, H.; Billmeier, A.; Blyth, C.O.; Bock, R.; Boimska, B.; Bormann, C.; Brady, F.P.; Brockmann, R.; Brun, R.; Buncic, P.; Caines, H.L.; Carr, L.D.; Cebra, D.A.; Cooper, G.E.; Cramer, J.G.; Cristinziani, M.; Csato, P.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Ferguson, M.I.; Fischer, H.G.; Flierl, D.; Fodor, Z.; Foka, P.; Freund, P.; Friese, V.; Fuchs, M.; Gabler, F.; Gal, J.; Ganz, R.; Gazdzicki, M.; Geist, Walter M.; Gladysz, E.; Grebieszkow, J.; Gunther, J.; Harris, J.W.; Hegyi, S.; Henkel, T.; Hill, L.A.; Hummler, H.; Igo, G.; Irmscher, D.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kolesnikov, V.I.; Kowalski, M.; Lasiuk, B.; Lednicky, R.; Levai, P.; Malakhov, A.I.; Margetis, S.; Markert, C.; Melkumov, G.L.; Mock, A.; Molnar, J.; Nelson, John M.; Oldenburg, M.; Odyniec, G.; Palla, G.; Panagiotou, A.D.; Petridis, A.; Piper, A.; Porter, R.J.; Poskanzer, Arthur M.; Prindle, D.J.; Puhlhofer, F.; Susa, T.; Reid, J.G.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Rohrich, D.; Roland, C.; Roland, G.; Rudolph, H.; Rybicki, A.; Sammer, T.; Sandoval, A.; Sann, H.; Semenov, A.Yu.; Schafer, E.; Schmischke, D.; Schmitz, N.; Schonfelder, S.; Seyboth, P.; Sikler, F.; Skrzypczak, E.; Snellings, R.; Squier, G.T.A.; Stock, R.; Strobele, H.; Struck, Chr.; Szentpetery, I.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Ullrich, T.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Voloshin, S.; Vranic, D.; Wang, F.; Weerasundara, D.D.; Wenig, S.; Whitten, C.; Wood, L.; Xu, N.; Yates, T.A.; Zimanyi, J.; Zhu, X.Z.; Zybert, R.

    1999-01-01

    The two-proton correlation function at midrapidity from Pb+Pb central collisions at 158 AGeV has been measured by the NA49 experiment. The results are compared to model predictions from static thermal Gaussian proton source distributions and transport models RQMD and VENUS. An effective proton source size is determined by minimizing CHI-square/ndf between the correlation functions of the data and those calculated for the Gaussian sources, yielding 3.85 +- 0.15 (stat.) +- 0.15 (syst.) fm. The RQMD model overpredicts the effective source size, while the VENUS model underpredicts the effective source size.

  14. Broadband radio circular polarization spectrum of the relativistic jet in PKS B2126-158

    CERN Document Server

    O'Sullivan, S P; Feain, I J; Gaensler, B M; Sault, R J

    2013-01-01

    We present full-Stokes radio polarization observations of the quasar PKS B2126-158 (z=3.268) from 1 to 10 GHz using the Australia Telescope Compact Array. The source has large fractional circular polarization, m_c \\equiv |V|/I, detected at high significance across the entire band (from 15 to 90\\sigma per 128 MHz sub-band). This allows us to construct the most robust circular polarization (CP) spectrum of an AGN jet to date. We find m_c \\propto \

  15. Novel planar Gunn diode operating in fundamental mode up to 158 GHz

    Energy Technology Data Exchange (ETDEWEB)

    Li Chong; Khalid, A; Holland, M C; Cumming, D S R [Department of Electronic and Electrical Engineering, University of Glasgow, Glasgow G12 8LT (United Kingdom); Pilgrim, N; Dunn, G, E-mail: lichong@elec.gla.ac.u [School of Engineering and Physical Sciences, University of Aberdeen, Aberdeen AB24 SFX (United Kingdom)

    2009-11-15

    We show the experimental realisation of fundamental mode operation of planar Gunn diode structures fabricated in GaAs/AlGaAs quantum wells. The electron density in the active channel is enhanced by positioning double delta-doping layers on either side. Small signal measurement shows that a typical device exhibits negative resistance up to 158 GHz. Using this device structure we have demonstrated a planar Gunn oscillator working at 115.5 GHz with an output power of -28 dBm.

  16. Novel planar Gunn diode operating in fundamental mode up to 158 GHz

    Science.gov (United States)

    Li, Chong; Khalid, A.; Pilgrim, N.; Holland, M. C.; Dunn, G.; Cumming, D. S. R.

    2009-11-01

    We show the experimental realisation of fundamental mode operation of planar Gunn diode structures fabricated in GaAs/AlGaAs quantum wells. The electron density in the active channel is enhanced by positioning double delta-doping layers on either side. Small signal measurement shows that a typical device exhibits negative resistance up to 158 GHz. Using this device structure we have demonstrated a planar Gunn oscillator working at 115.5 GHz with an output power of -28 dBm.

  17. Long-range correlations in PbPb collisions at 158 a *GeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, J; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csato, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gal, J; Gazdzicki, M; Georgopoulos, G; Gladysz, E; Grebieszkow, K; Hegyi, S; Hohne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; van Leeuwen, M; Levai, P; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnar, J; Mrowczynski, S; Palla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Puhlhofer, F; Renfordt, R; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Seyboth, P; Sikler, F; Sitar, B; Skrzypczak, E; Stefanek, G; Stock, R; Strobele, H; Susa, T; Szentpetery, I; Sziklai, J; Trubnikov, V; Varga, D; Vassiliou, M; Veres, G l; Vesztergombi, G; Vranie, D; Wetzler, A; Wlodarczyk, Z; Yoo, l K; Zaranek, J; Zimanyi, J; Feofilov, G; Kolevatov, R; Kondratiev, V; Naumenko, P; Vechernin, V

    2005-01-01

    We present the 1st results of the event-by-event study of long-range correlations between event mean Pt and charged particle multiplicity using NA49 experimental data in two separated rapidity intervals in 158 A *Ge V Pb Pb collisions at the CERN SPS. Noticeable long range correlations are found. The most striking feature is the negative Prn correlation observed for the central PbPb collisions. Results are compared to the predictions of the HIJING event generator and of the String Fusion Model favoring a string fusion hypothesis.

  18. [Acupuncture combined with catgut embedding therapy for treatment of 158 cases of facial paralysis].

    Science.gov (United States)

    Li, Ling

    2005-03-01

    To observe therapeutic effect of acupuncture combined with catgut embedding therapy on peripheral facial paralysis. Treatment group of 158 cases were treated by acupuncture combined with catgut embedding therapy and control group of 54 cases were treated by acupuncture, and their therapeutic effects were compared. There was no significant difference in the total effective rate (P > 0.05), but the cured rate in the treatment group was significantly higher than that in the control group (P Acupuncture combined with catgut embedding therapy is a better therapy for facial paralysis.

  19. Production of Λ -hyperons in inelastic p+p interactions at 158 {GeV}/c

    Science.gov (United States)

    Aduszkiewicz, A.; Ali, Y.; Andronov, E.; Antićić, T.; Antoniou, N.; Baatar, B.; Bay, F.; Blondel, A.; Bogomilov, M.; Brandin, A.; Bravar, A.; Brzychczyk, J.; Bunyatov, S. A.; Busygina, O.; Christakoglou, P.; Ćirković, M.; Czopowicz, T.; Damyanova, A.; Davis, N.; Dembinski, H.; Deveaux, M.; Diakonos, F.; Di Luise, S.; Dominik, W.; Dumarchez, J.; Dynowski, K.; Engel, R.; Ereditato, A.; Feofilov, G. A.; Fodor, Z.; Garibov, A.; Gaździcki, M.; Golubeva, M.; Grebieszkow, K.; Grzeszczuk, A.; Guber, F.; Haesler, A.; Hasegawa, T.; Hervé, A. E.; Hierholzer, M.; Igolkin, S.; Ivashkin, A.; Johnson, S. R.; Kadija, K.; Kapoyannis, A.; Kaptur, E.; Kisiel, J.; Kobayashi, T.; Kolesnikov, V. I.; Kolev, D.; Kondratiev, V. P.; Korzenev, A.; Kowalik, K.; Kowalski, S.; Koziel, M.; Krasnoperov, A.; Kuich, M.; Kurepin, A.; Larsen, D.; László, A.; Lewicki, M.; Lyubushkin, V. V.; Maćkowiak-Pawłowska, M.; Maksiak, B.; Malakhov, A. I.; Manić, D.; Marcinek, A.; Marino, A. D.; Marton, K.; Mathes, H.-J.; Matulewicz, T.; Matveev, V.; Melkumov, G. L.; Messerly, B.; Mills, G. B.; Morozov, S.; Mrówczyński, S.; Nagai, Y.; Nakadaira, T.; Naskręt, M.; Nirkko, M.; Nishikawa, K.; Panagiotou, A. D.; Paolone, V.; Pavin, M.; Petukhov, O.; Pistillo, C.; Płaneta, R.; Popov, B. A.; Posiadała, M.; Puławski, S.; Puzović, J.; Rauch, W.; Ravonel, M.; Redij, A.; Renfordt, R.; Richter-Wąs, E.; Robert, A.; Röhrich, D.; Rondio, E.; Roth, M.; Rubbia, A.; Rumberger, B. T.; Rustamov, A.; Rybczynski, M.; Sadovsky, A.; Sakashita, K.; Schmidt, K.; Sekiguchi, T.; Selyuzhenkov, I.; Seryakov, A.; Seyboth, P.; Sgalaberna, D.; Shibata, M.; Słodkowski, M.; Staszel, P.; Stefanek, G.; Stepaniak, J.; Ströbele, H.; Šuša, T.; Szuba, M.; Tada, M.; Taranenko, A.; Tefelski, D.; Tereshchenko, V.; Tsenov, R.; Turko, L.; Ulrich, R.; Unger, M.; Vassiliou, M.; Veberič, D.; Vechernin, V. V.; Vesztergombi, G.; Vinogradov, L.; Wilczek, A.; Włodarczyk, Z.; Wojtaszek-Szwarc, A.; Wyszyński, O.; Zambelli, L.; Zimmerman, E. D.

    2016-04-01

    Inclusive production of Λ -hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158 {GeV}/c. Spectra of transverse momentum and transverse mass as well as distributions of rapidity and x_{_F} are presented. The mean multiplicity was estimated to be 0.120 {± } 0.006(stat.){± }0.010(sys.). The results are compared with previous measurements and predictions of the Epos, Ur qmd and Fritiof models.

  20. Baryon and antibaryon production in lead-lead collisions at 158 A GeV/c

    Science.gov (United States)

    Newmass (NA52) Collaboration; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Bohm, C.; Borer, K.; Bussière, A.; Dittus, F.; Elsener, K.; Frei, D.; Gorodetzky, Ph.; Guillaud, J. P.; Hess, P.; Hugentobler, E.; Kabana, S.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pal, T.; Pretzl, K.; Schacher, J.; Selldén, B.; Stoffel, F.; Tuominiemi, J.; Weber, M.; Zhang, Q. P.

    1998-01-01

    We report on baryon and antibaryon as well as K+ and K- production cross sections measured in lead-lead collisions at 158 GeV/c per nucleon. The presented data were taken at zero degree production angle with a minimum bias trigger. The measurements covered a wide range of rapidity 1.4

  1. Strangelet Search in Pb-Pb Interactions at 158 GeV /c per Nucleon

    Science.gov (United States)

    Appelquist, G.; Baglin, C.; Beringer, J.; Bohm, C.; Borer, K.; Bussière, A.; Dittus, F.; Elsener, K.; Frei, D.; Gorodetzky, Ph.; Guillaud, J. P.; Hugentobler, E.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Moser, U.; Pal, T.; Pretzl, K.; Schacher, J.; Selldén, B.; Stoffel, F.; Tuominiemi, J.; Zhang, Q. P.

    1996-05-01

    The NA52 experiment searches for long-lived massive strange quark matter particles, so-called strangelets, produced in Pb-Pb collisions at a beam momentum of plab = 158 A GeV/c. Upper limits for the production of strangelets at zero degree production angle covering a mass to charge ratio up to 120 GeV/c2 and lifetimes tlab>~1.2 μs are given. The data presented here were taken during the 1994 lead beam running period at CERN.

  2. Strangelet search in Pb-Pb interactions at 158 GeV/{ital c} per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Appelquist, G.; Baglin, C.; Beringer, J.; Bohm, C.; Borer, K.; Bussiere, A.; Dittus, F.; Elsener, K.; Frei, D.; Gorodetzky, P.; Guillaud, J.P.; Hugentobler, E.; Klingenberg, R.; Linden, T.; Lohmann, K.D.; Moser, U.; Pal, T.; Pretzl, K.; Schacher, J.; Sellden, B.; Stoffel, F.; Tuominiemi, J.; Zhang, Q.P. [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland)]|[CERN, SL Division, CH-1211 Geneva 23 (Switzerland)]|[CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France)]|[Department of Physics, University of Helsinki, P.O. Box 9, FIN-00014 Helsinki (Finland)]|[Department of Physics, University of Stockholm, P.O. Box 6730, S-11385 Stockholm (Sweden)]|[CNRS-IN2P3, CRN Strasbourg, F-67037 Strasbourg (France)

    1996-05-01

    The NA52 experiment searches for long-lived massive strange quark matter particles, so-called {ital strangelets}, produced in Pb-Pb collisions at a beam momentum of {ital p}{sub lab}=158 AGeV/{ital c}. Upper limits for the production of strangelets at zero degree production angle covering a mass to charge ratio up to 120 GeV/{ital c}{sup 2} and lifetimes {ital t}{sub lab}{approx_gt}1.2 {mu}s are given. The data presented here were taken during the 1994 lead beam running period at CERN. {copyright} {ital 1996 The American Physical Society.}

  3. A Preliminary Measurement of the Left-Right Parity-Violating ep Asymmetry at E158

    Energy Technology Data Exchange (ETDEWEB)

    Biesiada, J.

    2005-04-11

    This thesis investigates the parity-violating ep asymmetry based on the Run I data produced in Spring of 2002 by the E158 experiment, located at the Stanford Linear Accelerator Center. The main scientific objective of the experiment is the precision measurement of the weak mixing angle of the Standard Model. The ep asymmetry is an important background in the experiment and theoretically interesting in its own right, providing insights into the structure of the proton. The analysis centers upon identifying systematic error and consistency. The definite measurement of the ep asymmetry will await the final reprocessing of the data set during the Fall of 2002.

  4. Production of $\\Lambda$ hyperons in inelastic p+p interactions at 158 GeV/$c$

    CERN Document Server

    Aduszkiewicz, A.; Andronov, E.; Antićić, T.; Antoniou, N.; Baatar, B.; Bay, F.; Blondel, A.; Bogomilov, M.; Brandin, A.; Bravar, A.; Brzychczyk, J.; Bunyatov, S.A.; Busygina, O.; Christakoglou, P.; Ćirković, M.; Czopowicz, T.; Damyanova, A.; Davis, N.; Dembinski, H.; Deveaux, M.; Diakonos, F.; Di Luise, S.; Dominik, W.; Dumarchez, J.; Dynowski, K.; Engel, R.; Ereditato, A.; Feofilov, G.A.; Fodor, Z.; Garibov, A.; Gazdzicki, M.; Golubeva, M.; Grebieszkow, K.; Grzeszczuk, A.; Guber, F.; Haesler, A.; Hasegawa, T.; Hervé, A.E.; Hierholzer, M.; Igolkin, S.; Ivashkin, A.; Johnson, S.R.; Kadija, K.; Kapoyannis, A.; Kaptur, E.; Kisiel, J.; Kobayashi, T.; Kolesnikov, V.I.; Kolev, D.; Kondratiev, V.P.; Korzenev, A.; Kowalik, K.; Kowalski, S.; Koziel, M.; Krasnoperov, A.; Kuich, M.; Kurepin, A.; Larsen, D.; László, A.; Lewicki, M.; Lyubushkin, V.V.; Maćkowiak-Pawłowska, M.; Maksiak, B.; Malakhov, A.I.; Manić, D.; Marcinek, A.; Marino, A.D.; Marton, K.; Mathes, H.J.; Matulewicz, T.; Matveev, V.; Melkumov, G.L.; Messerly, B.; Mills, G.B.; Morozov, S.; Mrówczyński, S.; Nagai, Y.; Nakadaira, T.; Naskręt, M.; Nirkko, M.; Nishikawa, K.; Panagiotou, A.D.; Paolone, V.; Pavin, M.; Petukhov, O.; Pistillo, C.; Płaneta, R.; Popov, B.A.; Posiadała, M.; Puławski, S.; Puzović, J.; Rauch, W.; Ravonel, M.; Redij, A.; Renfordt, R.; Richter-Wąs, E.; Robert, A.; Röhrich, D.; Rondio, E.; Roth, M.; Rubbia, A.; Rumberger, B.T.; Rustamov, A.; Rybczynski, M.; Sadovsky, A.; Sakashita, K.; Schmidt, K.; Sekiguchi, T.; Selyuzhenkov, I.; Seryakov, A.; Seyboth, P.; Sgalaberna, D.; Shibata, M.; Słodkowski, M.; Staszel, P.; Stepaniak, J.; Stefanek, G.; Ströbele, H.; Šuša, T.; Szuba, M.; Tada, M.; Taranenko, A.; Tefelski, D.; Tereshchenko, V.; Tsenov, R.; Turko, L.; Ulrich, R.; Unger, M.; Vassiliou, M.; Veberič, D.; Vechernin, V.V.; Vesztergombi, G.; Vinogradov, L.; Wilczek, A.; Włodarczyk, Z.; Wojtaszek-Szwarc, A.; Wyszyński, O.; Zambelli, L.; Zimmerman, E.D.; Zambelli, L.; Zimmermann, E.D.

    2016-01-01

    Inclusive production of $\\Lambda$-hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158 GeVc. Spectra of transverse momentum and transverse mass as well as distributions of rapidity and x$_{_F}$ are presented. The mean multiplicity was estimated to be $0.120\\,\\pm0.006\\;(stat.)\\,\\pm 0.010\\;(sys.)$. The results are compared with previous measurements and predictions of the EPOS, UrQMD and FRITIOF models.

  5. Extension of the energy range of the experimental activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium up to 65 MeV

    CERN Document Server

    Tárkányi, F; Takács, S; Hermanne, A; Ignatyuk, A V

    2016-01-01

    Activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium were extended up to 65 MeV by using stacked foil irradiation and gamma spectrometry experimental methods. Experimental cross-sections data for the formation of the radionuclides $^{159}$Dy, $^{157}$Dy, $^{155}$Dy, $^{161}$Tb, $^{160}$Tb, $^{156}$Tb, $^{155}$Tb, $^{154m2}$Tb, $^{154m1}$Tb, $^{154g}$Tb, $^{153}$Tb, $^{152}$Tb and $^{151}$Tb are reported in the 36-65 MeV energy range, and compared with an old dataset from 1964. The experimental data were also compared with the results of cross section calculations of the ALICE and EMPIRE nuclear model codes and of the TALYS nuclear reaction model code as listed in the latest on-line libraries TENDL 2013.

  6. Extension of the energy range of the experimental activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium up to 65MeV.

    Science.gov (United States)

    Tárkányi, F; Ditrói, F; Takács, S; Hermanne, A; Ignatyuk, A V

    2015-04-01

    Activation cross-sections data of longer-lived products of proton induced nuclear reactions on dysprosium were extended up to 65MeV by using stacked foil irradiation and gamma spectrometry experimental methods. Experimental cross-sections data for the formation of the radionuclides (159)Dy, (157)Dy, (155)Dy, (161)Tb, (160)Tb, (156)Tb, (155)Tb, (154m2)Tb, (154m1)Tb, (154g)Tb, (153)Tb, (152)Tb and (151)Tb are reported in the 36-65MeV energy range, and compared with an old dataset from 1964. The experimental data were also compared with the results of cross section calculations of the ALICE and EMPIRE nuclear model codes and of the TALYS nuclear reaction model code as listed in the latest on-line libraries TENDL 2013. Copyright © 2015. Published by Elsevier Ltd.

  7. Pulse Pressure magnifies the effect of COMTVal158Met on 15 Year Episodic Memory Trajectories

    Directory of Open Access Journals (Sweden)

    Ninni ePersson

    2016-03-01

    Full Text Available We investigated whether a physiological marker of cardiovascular health, pulse pres­sure (PP, and age magnified the effect of the functional COMT Val158Met (rs4680 pol­ymor­phism on 15-year cognitive trajectories (episodic memory [EM], visuospatial ability, and se­man­tic memory using data from 1585 non-demented adults from the Betula study. A mul­tiple-group growth model was specified to gauge individual differences in change. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val158Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by sta­tistical control for PP. Further, PP mod­erated the effects of COMT on 15-year EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (dia­betes, stroke, and hypertension, and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in nor­mal cognitive aging, as the addition thereof may even place healthy individuals at greater risk for memory decline.

  8. Neon and [CII] 158 micron Emission Line Profiles in Dusty Starbursts and Active Galactic Nuclei

    CERN Document Server

    Samsonyan, Anahit; Lebouteiller, Vianney; Barry, Donald; Sargsyan, Lusine

    2016-01-01

    The sample of 379 extragalactic sources is presented that have mid-infrared, high resolution spectroscopy with the Spitzer Infrared Spectrograph (IRS) and also spectroscopy of the [CII] 158 um line with the Herschel Photodetector Array Camera and Spectrometer (PACS). The emission line profiles of [NeII] 12.81 um, [NeIII] 15.55 um, and [CII] 158 um are presented, and intrinsic line widths are determined (full width half maximum of Gaussian profiles after instrumental correction). All line profiles together with overlays comparing positions of PACS and IRS observations are made available in the Cornell Atlas of Spitzer IRS Sources (CASSIS). Sources are classified from AGN to starburst based on equivalent widths of the 6.2 um polycyclic aromatic hydrocarbon feature. It is found that intrinsic line widths do not change among classification for [CII], with median widths of 207 km per s for AGN, 248 km per s for composites, and 233 km per s for starbursts. The [NeII] line widths also do not change with classificati...

  9. Studying the spatially resolved Schmidt-Kennicutt law in interacting galaxies: the case of Arp 158

    CERN Document Server

    Boquien, Médéric; Duc, Pierre-Alain; Braine, Jonathan; Bournaud, Frédéric; Brinks, Elias; Charmandaris, Vassilis

    2011-01-01

    Recent studies have shown that star formation in mergers does not seem to follow the same Schmidt-Kennicutt (KS) relation as in spiral disks, presenting a higher star formation rate (SFR) for a given gas column density. In this paper we study why and how different models of star formation arise. To do so we examine the process of star formation in the interacting system Arp 158 and its tidal debris. We perform an analysis of the properties of specific regions of interest in Arp 158 using observations tracing the atomic and the molecular gas, star formation, the stellar populations as well as optical spectroscopy to determine their exact nature. We also fit their spectral energy distribution with an evolutionary synthesis code. Finally, we compare star formation in these objects to star formation in the disks of spiral galaxies and mergers. Abundant molecular gas is found throughout the system and the tidal tails appear to have many young stars compared to their old stellar content. One of the nuclei is domina...

  10. Study of projectile fragmentation in the reaction (158AGeV) Pb + Pb using CR-39

    Energy Technology Data Exchange (ETDEWEB)

    Qureshi, I.E. [Physics Research Division, PINSTECH, P.O. Nilore, Islamabad (Pakistan)]. E-mail: imtinan@pinstech.org.pk; Shahzad, M.I. [Physics Research Division, PINSTECH, P.O. Nilore, Islamabad (Pakistan); Javed, M.T. [Centre for High Energy Physics, University of the Punjab, Lahore (Pakistan); Manzoor, S. [Physics Research Division, PINSTECH, P.O. Nilore, Islamabad (Pakistan); Sher, G. [Physics Research Division, PINSTECH, P.O. Nilore, Islamabad (Pakistan); Aleem, F. [Centre for High Energy Physics, University of the Punjab, Lahore (Pakistan); Khan, H.A. [COMSATS, Shahrah-e-Jamhuriyyat, G-5/2, Islamabad (Pakistan)

    2005-11-15

    The fragmentation of Pb ions at 158AGeV energy produced in the interaction with Pb target has been studied using a CR-39 track detector. A stack comprising of 64 detectors was prepared such that a target of 1cm thickness was sandwiched between the sheets of CR-39. The purpose of this exposure geometry was to calibrate CR-39 with respect to relativistic heavy ions as well as to study the fragmentation of Pb ions at 158AGeV energy. The exposure was carried out at the SPS beam facility of CERN at normal incidence with a fluence of {approx}1500ion/cm{sup 2}. Two detectors from the exposed stack have been selected for this study: one before and the other after the target material. After etching, the detectors were scanned using an optical microscope and the etched track lengths and the diameters of the track openings were measured manually. Considering that the lengths of tracks provide the best charge resolution for Z>65, we have measured track lengths for a sufficiently large number of fragments to identify individual charge states for 65

  11. 158例热性惊厥儿童的脑电图分析%Analysis of Electroencephalogram in 158 Children with Febrile Convulsion

    Institute of Scientific and Technical Information of China (English)

    王元青

    2012-01-01

    目的 探讨热性惊厥(FC)患儿异常脑电图(EEG)与临床特征的关系,以及和以后FC的再发及移行为癫痫(EP)发作的关系.方法 记录158例6个月~6岁患儿FC后EEG.结果 EEG异常率与性别无关;3岁以后首发FC的EEG异常率较3岁以内的高;FC再发者EEG异常率较首次FC发作者高;FC大多发生于体温≥38.5℃,但初发体温<38.5℃,EEG异常发生率明显增高;局灶性发作和FC发作持续时间≥ 15min者的EEG异常率较全身性发作及发作持续时间<15min者高;有阳性家族史者EEG异常率明显升高.其中有6例FC经过2~5年的随访,最后诊断为EP.结论 FC患者EEG的异常率与阳性家族史及临床特征有明显关系,EEG对FC的早期分类诊断和进行预防性治疗有指导意义.

  12. The roles of COMT val158met status and aviation expertise in flight simulator performance and cognitive ability.

    Science.gov (United States)

    Kennedy, Q; Taylor, J L; Noda, A; Adamson, M; Murphy, G M; Zeitzer, J M; Yesavage, J A

    2011-09-01

    The polymorphic variation in the val158met position of the catechol-O-methyltransferase (COMT) gene is associated with differences in executive performance, processing speed, and attention. The purpose of this study is: (1) replicate previous COMT val158met findings on cognitive performance; (2) determine whether COMT val158met effects extend to a real-world task, aircraft navigation performance in a flight simulator; and (3) determine if aviation expertise moderates any effect of COMT val158met status on flight simulator performance. One hundred seventy two pilots aged 41-69 years, who varied in level of aviation training and experience, completed flight simulator, cognitive, and genetic assessments. Results indicate that although no COMT effect was found for an overall measure of flight performance, a positive effect of the met allele was detected for two aspects of cognitive ability: executive functioning and working memory performance. Pilots with the met/met genotype benefited more from increased levels of expertise than other participants on a traffic avoidance measure, which is a component of flight simulator performance. These preliminary results indicate that COMT val158met polymorphic variation can affect a real-world task.

  13. Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chronic tension-type headache.

    Science.gov (United States)

    Fernández-de-las-Peñas, César; Ambite-Quesada, Silvia; Rivas-Martínez, Inés; Ortega-Santiago, Ricardo; de-la-Llave-Rincón, Ana Isabel; Fernández-Mayoralas, Daniel M; Pareja, Juan A

    2011-10-01

    Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case-control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and 70 healthy children participated. After amplifying Val158Met polymorphism by polymerase chain reactions, we assessed genotype frequencies and allele distributions. We classified children according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. Pressure pain thresholds (PPT) were bilaterally assessed over the temporalis, upper trapezius, second metacarpal, and tibialis anterior muscles. The distribution of Val158Met genotypes was not significantly different (p = 0.335), between children with CTTH and healthy children, and between boys and girls (p = 0.872). Children with CTTH with the Met/Met genotype showed a longer headache history compared with those with Met/Val (p = 0.001) or Val/Val (p = 0.002) genotype. Children with CTTH with Met/Met genotype showed lower PPT over upper trapezius and temporalis muscles than children with CTTH with Met/Val or Val/Val genotype (p < 0.01). The Val158Met catechol-O-methyltransferase (COMT) polymorphism does not appear to be involved in predisposition to suffer from CTTH in children; nevertheless, this genetic factor may be involved in the phenotypic expression, as pressure hypersensitivity was greater in those CTTH children with the Met/Met genotype.

  14. Association between the Catechol O-methyltransferase (COMT Val158met polymorphism and different dimensions of impulsivity.

    Directory of Open Access Journals (Sweden)

    Leandro Fernandes Malloy-Diniz

    Full Text Available BACKGROUND: Impulsivity is a multidimensional construct which has been associated with dopaminergic neurotransmission. Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val with methionine (met in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met. The present study aimed to investigate the association between val158met COMT polymorphism and impulsive behavior measured by two neuropsychological tests. METHODOLOGY/PRINCIPAL FINDINGS: We administered two neuropsychological tests, a Continuous Performance Task and the Iowa Gambling Task were applied to 195 healthy participants to characterize their levels of motor, attentional and non-planning impulsivity. Then, subjects were grouped by genotype, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional and motor impulsivity. Those participants who were homozygous for the met allele performed worse in the Iowa Gambling Task than val/val and val/met subjects. CONCLUSIONS/SIGNIFICANCE: Our results suggest that met allele of val158met COMT polymorphism is associated with poor performance in decision-making/cognitive impulsivity task. The results reinforce the hypothesis that val and met alleles of the val158met polymorphism show functional dissociation and are related to different prefrontal processes.

  15. Functional characterizations of residues Arg-158 and Tyr-170 of the mosquito-larvicidal Bacillus thuringiensis Cry4Ba

    Science.gov (United States)

    Leetachewa, Somphob; Moonsom, Saengduen; Chaisri, Urai; Khomkhum, Narumol; Yoonim, Nonglak; Wang, Ping; Angsuthanasombat, Chanan

    2014-01-01

    The insecticidal activity of Bacillus thuringiensis (Bt) Cry toxins involves toxin stabilization, oligomerization, passage across the peritrophic membrane (PM), binding to midgut receptors and pore-formation. The residues Arg-158 and Tyr-170 have been shown to be crucial for the toxicity of Bt Cry4Ba. We characterized the biological function of these residues. In mosquito larvae, the mutants R158A/E/Q (R158) could hardly penetrate the PM due to a significantly reduced ability to alter PM permeability; the mutant Y170A, however, could pass through the PM, but degraded in the space between the PM and the midgut epithelium. Further characterization by oligomerization demonstrated that Arg-158 mutants failed to form correctly sized high-molecular weight oligomers. This is the first report that Arg-158 plays a role in the formation of Cry4Ba oligomers, which are essential for toxin passage across the PM. Tyr-170, meanwhile, is involved in toxin stabilization in the toxic mechanism of Cry4Ba in mosquito larvae. [BMB Reports 2014; 47(10): 546-551] PMID:24286331

  16. GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role.

    Science.gov (United States)

    Patel, Nitin; Itakura, Tatsuo; Gonzalez, Jose M; Schwartz, Stephen G; Fini, M Elizabeth

    2013-01-01

    Members of the large G protein-coupled receptor (GPCR) clan are implicated in many physiological and disease processes, making them important therapeutic drug targets. In the present study, we follow up on results of a pilot study suggesting a functional relationship between glucocorticoid (GC)-induced ocular hypertension and GPR158, one of three orphan members of the GPCR Family C. GC treatment increases levels of GPR158 mRNA and protein through transcriptional mechanisms, in cultured trabecular meshwork (TBM) cells derived from the eye's aqueous outflow pathway. Like treatment with GCs, transient overexpression of GPR158 stimulates cell proliferation, while siRNA knockdown of endogenous GPR158 has the opposite effect. Both endogenous and overexpressed GPR158 show an unusual subcellular localization pattern, being found almost entirely in the nucleus. However, when cells are treated with inhibitors of clathrin-mediated endocytosis, GPR158 is shifted to the plasma membrane. Mutation of a bipartite nuclear localization signal (NLS) in the 8(th) helix also shifts GPR158 out of the nucleus, but in this case the protein is found in vesicles localized in the cytoplasm. These results suggest that newly synthesized GPR158 first traffics to the plasma membrane, where it rapidly undergoes endocytosis and translocation to the nucleus. Significantly, mutation of the NLS abrogates GPR158-mediated enhancement of cell proliferation, indicating a functional requirement for nuclear localization. GPR158 overexpression upregulates levels of the cell cycle regulator cyclin D1, but mutation of the NLS reverses this. Overexpression of GPR158 enhances the barrier function of a TBM cell monolayer, which is associated with an increase in the levels of tight junction proteins ZO-1 and occludin, similar to reported studies on GC treatment. Regulated paracellular permeability controls aqueous outflow facility in vivo. Since GCs stimulate GPR158 expression, the result is consistent with a

  17. Dysprosium selective potentiometric membrane sensor

    Energy Technology Data Exchange (ETDEWEB)

    Zamani, Hassan Ali, E-mail: haszamani@yahoo.com [Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad (Iran, Islamic Republic of); Faridbod, Farnoush; Ganjali, Mohammad Reza [Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran (Iran, Islamic Republic of)

    2013-03-01

    A novel Dy(III) ion-selective PVC membrane sensor was made using a new synthesized organic compound, 3,4-diamino-N Prime -((pyridin-2-yl)methylene)benzohydrazide (L) as an excellent sensing element. The electrode showed a Nernstian slope of 19.8 {+-} 0.6 mV per decade in a wide concentration range of 1.0 Multiplication-Sign 10{sup -6}-1.0 Multiplication-Sign 10{sup -2} mol L{sup -1}, a detection limit of 5.5 Multiplication-Sign 10{sup -7} mol L{sup -1}, a short conditioning time, a fast response time (< 10 s), and high selectivity towards Dy(III) ion in contrast to other cations. The proposed sensor was successfully used as an indicator electrode in the potentiometric titration of Dy(III) ions with EDTA. The membrane sensor was also applied to the F{sup -} ion indirect determination of some mouth washing solutions and to the Dy{sup 3+} determination in binary mixtures. Highlights: Black-Right-Pointing-Pointer The novelty of this work is based on the high affinity of the ionophore toward the Dy{sup 3+} ions. Black-Right-Pointing-Pointer This technique is very simple, fast and inexpensive and it is not necessary to use sophisticated equipment. Black-Right-Pointing-Pointer The newly developed sensor is superior to the formerly reported Dy{sup 3+} sensors in terms of selectivity.

  18. The magnetocaloric effect in dysprosium

    Science.gov (United States)

    Benford, S. M.

    1979-01-01

    The magnetocaloric effect in polycrystalline Dy was measured in the 84-280-K range in measuring fields from 1 to 7 T. These adiabatic temperature changes reflect structural changes in Dy with applied field and temperature, and include the first magnetocaloric data for a helical antiferromagnet. Above the Neel point (179 K) a field increase always caused heating; below the Neel point fields less than about 2 T cause cooling for some values of initial temperature. The largest temperature increase with a 7 T field occurs at the Neel point and at fields below 2 T near the Curie point. For refrigeration purposes the optimal working region for a Dy cooling element is field dependent.

  19. Interacciones moleculares en la transferencia conjugativa del plásmido pMV158

    OpenAIRE

    2009-01-01

    La conjugación bacteriana es la transferencia de material genético desde uuna célula donadora a otra receptora mediante contacto físico. Por su alta capacidad de establecimiento en diversos patógenos Gram-positivos, pMV158 es un sistema interesante para el estudio del proceso conjugativo. Este plásmido contiene un origen de transferencia (oriT) yel fen mobM, que codifica la proteína iniciadora de la conjugación MobM. En el capítulo 1 se anaaliza la expresión del gen mobM. La RNA polimerasa d...

  20. A disk asymmetry in motion around the B[e] star MWC158

    CERN Document Server

    Kluska, J; Soulez, F; Berger, J -P; Bouquin, J -B Le; Malbet, F; Lazareff, B; Thiébaut, E

    2016-01-01

    MWC158 is a star with the B[e] phenomenon that shows strong spectrophotometric variability (in lines and in UV and visible continuum) attributed to phases of shell ejection. The evolutionary stage of this star was never clearly determined. Previous interferometric, spectropolarimetric and spectro-interferometric studies suggest a disk morphology for its environment. We investigate the origin of the variability within the inner astronomical unit of the central star using near-infrared interferometric observations with PIONIER at the VLTI over a two-year period. We performed an image reconstruction of the circumstellar environment using the SPARCO method. We discovered that the morphology of the circumstellar environment could vary on timescales of weeks or days. We carried out a parametric fit of the data with a model consisting of a star, a disk and a bright spot that represents a brighter emission in the disk. We detect strong morphological changes in the first astronomical unit around the star, that happen ...

  1. Strangeness production in pA and AA collisions at 158 A GeV

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    LUCIAE, a hadronic and string cascade model and its corresponding event generator are used to analyse strangeness production singly and multiply in p-Pb and Pb-Pb collisions at 158 A GeV. Spectra of multiplicity and transverse mass for single (Λ, Λ) and multiple (Ξ-, Ξ-, Ω-, Ω-) strangeness are given. In LUCIAE model it suggests a physical mechanism, i.e. the dependence of the strange quark suppression factor on incident energy, projectile mass and centrality of colliding system might result in increase of yield of strange particles with increasing the above three parameters. Calculations from the model reconstruct well the WA97 experimental data: increase of yield of strange particles with increasing centrality and increase of strangeness enhancement with increasing number of strange quarks, in relativistic nucleus-nucleus collisions.

  2. Strangeness production in pA and AA collisions at 158 A GeV

    Institute of Scientific and Technical Information of China (English)

    王晓荣[1; 萨本豪[2; 周代翠[3; 刘涵[4; 蔡勖[5

    2000-01-01

    LUCIAE, a hadronic and string cascade model and its corresponding event generator are used to analyse strangeness production singly and multiply in p-Pb and Pb-Pb collisions at 158 A GeV. Spectra of multiplicity and transverse mass for single (Α ,Α ) and multiple (Ε Ε ) strangeness are given. in LUCIAE model it suggests a physical mechanism, i.e. the dependence of the strange quark suppression factor on incident energy, projectile mass and centrality of colliding sys-tem might result in increase of yield of strange particles with increasing the above three parameters. Calculations from the model reconstruct well the WA97 experimental data: increase of yield of strange particles with increasing centrality and increase of strangeness enhancement with increasing number of strange quarks, in relativistic nucleus-nucleus collisions.

  3. Hadronic Expansion Dynamics in Central Pb+Pb Collisions at 158 GeV per Nucleon

    CERN Document Server

    Appelshäuser, H; Bailey, S J; Barnby, L S; Bartke, Jerzy; Barton, R A; Bialkowska, H; Billmeier, A; Blyth, C O; Bock, R; Bormann, C; Brady, F P; Brockmann, R; Brun, R; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Dunn, J; Eckardt, V; Eckhardt, F; Ferguson, M I; Ferenc, D; Fischer, H G; Flierl, D; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Fuchs, M; Gabler, F; Gál, J; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Oldenburg, M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Petridis, A; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sandoval, A; Sann, H; Semenov, A Yu; Schäfer, E; Schmischke, D; Schmitz, N; Schönfelder, S; Seyboth, P; Seyerlein, J; Siklér, F; Skrzypczak, E; Squier, G T A; Stock, Reinhard; Ströbele, H; Struck, C; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Vassiliou, Maria; Vesztergombi, G; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wienold, T; Wood, L; Yates, T A; Xu, N; Zimányi, J; Zhu, X Z; Zybert, R

    1998-01-01

    Two-particle correlation functions of negative hadrons over wide phase space, and transverse mass spectra of negative hadrons and deuterons near mid-rapidity have been measured in central Pb+Pb collisions at 158 GeV per nucleon by the NA49 experiment at the CERN SPS. A novel Coulomb correction procedure for the negative two-particle correlations is employed making use of the measured oppositely charged particle correlation. Within an expanding source scenario these results are used to extract the dynamic characteristics of the hadronic source, resolving the ambiguities between the temperature and transverse expansion velocity of the source, that are unavoidable when single and two particle spectra are analysed separately. The source shape, the total duration of the source expansion, the duration of particle emission, the freeze-out temperature and the longitudinal and transverse expansion velocities are deduced.

  4. $\\Xi$ and $\\overline{\\Xi}$ production in 158 GeV/nucleon Pb + Pb collisions

    CERN Document Server

    Appelshauser, H.; Bailey, S.J.; Barna, D.; Barnby, L.S.; Bartke, J.; Barton, R.A.; Bialkowska, H.; Billmeier, A.; Blyth, C.O.; Bock, R.; Bormann, C.; Brady, F.P.; Brockmann, R.; Brun, R.; Buncic, P.; Caines, H.L.; Carr, L.D.; Cebra, D.A.; Cooper, G.E.; Cramer, J.G.; Cristinziani, M.; Csato, P.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Ferguson, M.I.; Fischer, H.G.; Flierl, D.; Fodor, Z.; Foka, P.; Freund, P.; Friese, V.; Fuchs, M.; Gabler, F.; Geist, Walter M.; Gal, J.; Gazdzicki, M.; Gladysz, E.; Grebieszkow, J.; Gunther, J.; Harris, J.W.; Hegyi, S.; Henkel, T.; Hill, L.A.; Hummler, H.; Igo, G.; Irmscher, D.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kolesnikov, V.I.; Konashenok, A.; Kowalski, M.; Lasiuk, B.; Levai, P.; Liu, F.; Malakhov, A.I.; Margetis, S.; Markert, C.; Melkumov, G.L.; Mock, A.; Molnar, J.; Nelson, John M.; Oldenburg, M.; Odyniec, G.; Palla, G.; Panagiotou, A.D.; Petridis, A.; Piper, A.; Porter, R.J.; Poskanzer, Arthur M.; Prindle, D.J.; Puhlhofer, F.; Rauch, W.; Reid, J.G.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Rohrich, D.; Roland, C.; Roland, G.; Rudolph, H.; Rybicki, A.; Sandoval, A.; Sann, H.; Semenov, A.Yu.; Schafer, E.; Schmischke, D.; Schmitz, N.; Schonfelder, S.; Seyboth, P.; Seyerlein, J.; Sikler, F.; Skrzypczak, E.; Snellings, R.; Squier, G.T.A.; Stock, R.; Strobele, H.; Struck, C.; Susa, T.; Szentpetery, I.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Ullrich, T.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Vranic, D.; Wang, F.; Weerasundara, D.D.; Wenig, S.; Whitten, C.; Wienold, T.; Wood, L.; Xu, N.; Yates, T.A.; Zimanyi, J.; Zhu, X.Z.; Zybert, R.

    1998-01-01

    We report measurements of Xi and Xi-bar hyperon absolute yields as a function of rapidity in 158 GeV/c Pb+Pb collisions. At midrapidity, dN/dy = 2.29 +/- 0.12 for Xi, and 0.52 +/- 0.05 for Xi-bar, leading to the ratio of Xi-bar/Xi = 0.23 +/- 0.03. Inverse slope parameters fitted to the measured transverse mass spectra are of the order of 300 MeV near mid-rapidity. The estimated total yield of Xi particles in Pb+Pb central interactions amounts to 7.4 +/- 1.0 per collision. Comparison to Xi production in properly scaled p+p reactions at the same energy reveals a dramatic enhancement (about one order of magnitude) of Xi production in Pb+Pb central collisions over elementary hadron interactions.

  5. Elliptic flow of Lambda hyperons in Pb+Pb collisions at 158A GeV

    CERN Document Server

    Stefanek, G; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Flierl, D; Fodor, Z; Foka, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Laszlo, A; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Nicolic, V; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Prindle, D; Pühlhofer, F; Renfordt, R; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Schuster, T; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stock, R; Strabel, C; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Szymanski, P; Trubnikov, V; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Wojtaszek, A; Yoo, I K; Zimányi, J

    2007-01-01

    The elliptic flow of Lambda hyperons has been measured by the NA49 experiment at the CERN-SPS in semi-central Pb+Pb collisions at 158A GeV. The standard method of correlating particles with the event plane was used. Measurements of v2 near mid-rapidity are reported as a function of rapidity, centrality and transverse momentum. Elliptic flow of Lambda particles increases both with the impact parameter and with the transverse momentum. It is compared with v2 for pions and protons as well as with model calculations. The observation of large elliptic flow and its mass dependence suggest strong collective behaviour of the matter produced in collisions of heavy nuclei already at the SPS.

  6. Search for strangelets in Pb+Pb collisions at 158 A GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Arsenescu, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Baglin, C [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Beck, H P [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Borer, K [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Bussiere, A [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Elsener, K [CERN, SL Division, CH-1211 Geneva (Switzerland); Gorodetzky, Ph [SPCC - College de France, 11 Place Marcellin Berthelod, 75005 Paris (France); Guillaud, J P [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Kabana, S [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Klingenberg, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Lehmann, G [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Linden, T [Helsinki Insitute of Physics, PO Box 9, FIN-00014 Helsinki (Finland); Lohmann, K D [CERN, SL Division, CH-1211 Geneva (Switzerland); Mommsen, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Moser, U [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Pretzl, K [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Schacher, J [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Spiwoks, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Tuominiemi, J [Helsinki Insitute of Physics, PO Box 9, FIN-00014 Helsinki (Finland); Weber, M [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland)

    2002-11-01

    The NA52 experiment at CERN has investigated lead-lead collisions at 158 A GeV/c and searched for long-lived strange quark matter droplets, so-called strangelets, with a unique signature of a high mass-to-charge ratio. This ratio was measured in a focusing spectrometer equipped with a time-of-flight system. A total of 3x10{sup 11} Pb + Pb interactions at positive and 10{sup 13} at negative spectrometer polarities have been recorded. No strangelet has been observed, which sets experimental upper limits (90% CL) for the strangelet production at 3x10{sup -9} per interaction for positively charged and at 2x10{sup -10} per interaction for negatively charged strangelets.

  7. Search for strangelets in Pb + Pb collisions at 158 A GeV/c

    Science.gov (United States)

    Arsenescu, R.; Baglin, C.; Beck, H. P.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Kabana, S.; Klingenberg, R.; Lehmann, G.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Spiwoks, R.; Tuominiemi, J.; Weber, M.

    2002-11-01

    The NA52 experiment at CERN has investigated lead-lead collisions at 158 A GeV/c and searched for long-lived strange quark matter droplets, so-called strangelets, with a unique signature of a high mass-to-charge ratio. This ratio was measured in a focusing spectrometer equipped with a time-of-flight system. A total of 3×1011 Pb + Pb interactions at positive and 1013 at negative spectrometer polarities have been recorded. No strangelet has been observed, which sets experimental upper limits (90% CL) for the strangelet production at 3×10-9 per interaction for positively charged and at 2×10-10 per interaction for negatively charged strangelets.

  8. Antihelium-3 production in lead-lead collisions at 158 A GeV/c

    CERN Document Server

    Arsenescu, R; Beck, H P; Borer, K; Bussière, A; Elsener, K; Gorodetzky, P; Guillaud, J P; Kabana, S; Klingenberg, R; Lehmann, G; Lindén, T; Lohmann, K D; Mommsen, R K; Moser, U; Pretzl, K; Schacher, J; Spiwoks, R; Tuominiemi, J; Weber, M

    2003-01-01

    The NA-52 experiment measured particle and antiparticle yields at 0 deg production angle over a wide range in rapidity in lead-lead (Pb-Pb) collisions at 158 A GeV/c with a minimum bias trigger. Besides O(10 sup 6) antiprotons and O(10 sup 3) antideuterons a total of five antihelium-3 were found. The resulting invariant differential production cross sections at p sub t approx =0 GeV/c turn out to be E (d sup 3 sigma)/(dp sup 3) = (2.5 +- 1.8) x 10 sup - sup 7 bc sup 3 GeV sup - sup 2 at a rapidity of y = 3.4 in the laboratory system and (5.9 +- 3.4) x 10 sup - sup 8 bc sup 3 GeV sup - sup 2 at y = 4.0. The results are discussed in the framework of a simple coalescence model.

  9. Antihelium-3 production in lead-lead collisions at 158 A GeV/c

    Science.gov (United States)

    Arsenescu, R.; Baglin, C.; Beck, H. P.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Kabana, S.; Klingenberg, R.; Lehmann, G.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Spiwoks, R.; Tuominiemi, J.; Weber, M.

    2003-01-01

    The NA52 experiment measured particle and antiparticle yields at 0° production angle over a wide range in rapidity in lead-lead (Pb-Pb) collisions at 158 A GeV/c with a minimum bias trigger. Besides Script O(106) antiprotons (bar-p) and Script O(103) antideuterons (bar-d) a total of five antihelium-3 (overline-3He) were found. The resulting invariant differential overline-3He production cross sections at ptsimeq0 GeV/c turn out to be E (d3sigma)/(dp3) = (2.5 ± 1.8) × 10-7 bc3 GeV-2 at a rapidity of y = 3.4 in the laboratory system and (5.9 ± 3.4) × 10-8 bc3 GeV-2 at y = 4.0. The results are discussed in the framework of a simple coalescence model.

  10. Antihelium-3 production in lead-lead collisions at 158 A GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Arsenescu, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Baglin, C [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Beck, H P [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Borer, K [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Bussiere, A [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Elsener, K [CERN, SL Division, CH-1211 Geneva (Switzerland); Gorodetzky, Ph [SPCC - College de France, 11 Place Marcellin Berthelod, 75005 Paris (France); Guillaud, J P [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Kabana, S [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Klingenberg, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Lehmann, G [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Linden, T [Helsinki Insitute of Physics, PO Box 9, FIN-00014 Helsinki (Finland); Lohmann, K D [CERN, SL Division, CH-1211 Geneva (Switzerland); Mommsen, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Moser, U [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Pretzl, K [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Schacher, J [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Spiwoks, R [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Tuominiemi, J [Helsinki Insitute of Physics, PO Box 9, FIN-00014 Helsinki (Finland); Weber, M [Laboratory for High Energy Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland)

    2003-01-01

    The NA-52 experiment measured particle and antiparticle yields at 0 deg production angle over a wide range in rapidity in lead-lead (Pb-Pb) collisions at 158 A GeV/c with a minimum bias trigger. Besides O(10{sup 6}) antiprotons and O(10{sup 3}) antideuterons a total of five antihelium-3 were found. The resulting invariant differential production cross sections at p{sub t}{approx_equal}0 GeV/c turn out to be E (d{sup 3}{sigma})/(dp{sup 3}) = (2.5 {+-} 1.8) x 10{sup -7} bc{sup 3} GeV{sup -2} at a rapidity of y = 3.4 in the laboratory system and (5.9 {+-} 3.4) x 10{sup -8} bc{sup 3} GeV{sup -2} at y = 4.0. The results are discussed in the framework of a simple coalescence mode000.

  11. Val158Met COMT polymorphism and risk of aggression in alcohol dependence.

    Science.gov (United States)

    Soyka, Michael; Zill, Peter; Koller, Gabi; Samochowiec, Agnieszka; Grzywacz, Anna; Preuss, Ulrich W

    2015-01-01

    Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent in-patients (293 German patients and 499 controls, and additional 190 Polish patients as replication sample). As expected, patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism and more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. COMT genotype was not associated with a history of violent or non-violent crime. More studies are needed on the neurobiological basis of aggression and violence in alcoholism.

  12. Association study between COMT 158Met and creativity scores in bipolar disorder and healthy controls

    Directory of Open Access Journals (Sweden)

    Márcio Gerhardt Soeiro-de-Souza

    2014-03-01

    Full Text Available Background Bipolar disorder (BD patients have been reported to be associated higher creativity abilities, and recent data tend to support the hypothesis that dopaminergic system that could be associated with creativity. Catechol-O-methyltransferase (COMT is one of the major enzymes involved in the metabolic degradation of dopamine. The COMT gene polymorphism (rs4680 or Val158Met Met allele is reported to cause decreased activity of this enzyme in prefrontal cortex and improve performance in several cognitive domains. Objective The objective of this study was to evaluate the influence of Val158Met on creativity in BD type I and healthy controls. Methods Ninety-seven healthy volunteers and 120 BD type I were genotyped for COMT rs4680 and tested for creativity (Barrow Welsh Art Scale – BWAS and intelligence Wechsler Abbreviated Scale of Intelligence (WASI. Results COMT Met allele positively influenced creativity scores in healthy controls but not in BD subjects during mood episodes and euthymia. The presence of allele Met did not influence IQ scores. No influence of IQ total score on creativity was observed. Limitations control group presented higher IQ scores and euthymic group was under medication use. Discussion Our research suggests positive effect of COMT rs4680 (allele Met on creativity scores in healthy controls. One possible interpretation is that creativity is more likely to be associated with lesser degrees of bipolarity. The fact that the same results were not observed in BD may be associated to dysfunctions in the dopaminergic system that characterizes this disorder. Further studies with larger samples and other types of BD should explore the role of the dopaminergic system in creativity.

  13. Omega and Antiomega production in central Pb+Pb collisions at 40 and 158 AGeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    Results are presented on Omega production in central Pb+Pb collisions at 40 and 158 AGeV beam energy. Given are transverse-mass spectra, rapidity distributions, and total yields for the sum Omega+Antiomega at 40 AGeV and for Omega and Antiomega separately at 158 AGeV. The yields are strongly under-predicted by the string-hadronic UrQMD model and agree with predictions from a hadron gas model assuming strangeness under-saturation.

  14. 儿童攻击行为与COMT Val158Met及5-HTTLPR基因多态性关联分析%Association between aggressive behaviors and COMT Val158Met and 5-HTTLPR polymorphisms in children

    Institute of Scientific and Technical Information of China (English)

    曹玉萍; 李龙飞; 赵幸福; 张亚林

    2011-01-01

    目的 探讨儿茶酚胺氧位甲基转移酶(COMT)第158位密码子从缬氨酸到蛋氨酸的错义突变(Val158Met)多态性及5-羟色胺转运体(5-HTT)基因启动子区缺失/插入多态性(5-HTTLPR)是否为家庭暴力环境下儿童攻击行为的易感因素.方法 以家庭暴力环境下68例儿童作为研究对象,依据Achenbach儿童行为量表(父母卷)评分,其中24例为攻击行为高分组,44例为低分组.采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术,检测两组COMT Val158Met和5-HTTLPR多态性,对所得基因型和等位基因频率进行对照和关联分析.结果 攻击行为高分组与低分组COMT Val158Met多态性的各基因型差异(χ2=1.612,P=0.447)和等位基因频率差异(χ2=1.648,P=0.119)均无统计学意义.两组5-HTTLPR多态性的各基因型差异(χ2=1.807,P=0.405)和等位基因频率差异(χ2=0.403,P=0.527)亦无统计学意义.结论 本研究结果不支持COMT Val158Met和5-HTTLPR基因多态性是儿童攻击行为产生的易感因素.提示儿童攻击行为可能是多因素共同作用的结果.%Objective To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children. Methods A total of 68 children who were exposed to domestic violence were recruited. The frequencies of genotypes and alleles of COMT Val158Met and 5-HTTLPR were examined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. A comparison was conducted between 24 children with high scores of aggressive problems and 44 control children with low scores of aggressive problems according to Child Behavior Checklist ( for parents). Results There were no significant differences in genotypes of C OMT Vail 58Met (x2 = 1.612,P = 0. 447) and 5-HTTLPR (x2

  15. One-, two-, and three-particle distributions from 158A GeV/c central Pb+Pb collisions

    NARCIS (Netherlands)

    Aggarwal, MM; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Bathe, S; Batiounia, B; Bernier, T; Bhalla, KB; Bhatia, VS; Blume, C; Bucher, D; Busching, H; Carlen, L; Chattopadhyay, S; Decowski, MP; Delagrange, H; Donni, P; Majumdar, MRD; El Chenawi, K; Enosawa, K; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Kamermans, R; Karadjev, K; Karpio, K; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Lohner, H; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Miake, Y; Mishra, GC; Mohanty, B; Mora, MJ; Morrison, D; Mukhanova, T; Mukhopadhyay, DS; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Peressounko, D; Petracek, [No Value; Plasil, F; Purschke, ML; Rak, J; Raniwala, R; Raniwala, S; Rao, NK; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Rubio, JM; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Sood, G; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A.; Tykarski, L; v d Pijll, EC; v Eijndhoven, N; v Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Young, GR

    2003-01-01

    Several hadronic observables have been studied in central 158A GeV Pb+Pb collisions using data measured by the WA98 experiment at CERN: single pi(-) and K- production, as well as two- and three-pion interferometry. The Wiedemann-Heinz hydrodynamical model has been fitted to the pion spectrum, giving

  16. No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data

    Directory of Open Access Journals (Sweden)

    Genis Mendoza Alma D

    2011-09-01

    Full Text Available Abstract Background The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis. Methods We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases. Results No significant differences were found in the distribution of alleles (χ2 = 0.33, 1 df, p = 0.56 or genotypes (χ2 = 2.36, 2 df, p = 0.26. The meta-analysis comprising 12 association studies (including the present one showed that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-1.23, even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23. Conclusion Our results showed no association between COMTval158/met and suicidal behavior. However, more studies are necessary to determine conclusively an association between COMT and suicidal behavior.

  17. Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population.

    Science.gov (United States)

    González-Castro, Thelma Beatriz; Tovilla-Zárate, Carlos; Juárez-Rojop, Isela; Pool García, Sherezada; Genis, Alma; Nicolini, Humberto; López Narváez, Lilia

    2013-09-10

    Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. On the other hand, some studies have reported that the enzymatic activity of COMT is partly genetically determined. With regard to the COMT gene, the most studied polymorphism is the functional variant Val108/158Met (rs4680), which results in substantial three- to four-fold variations in enzyme activity. To date, the rs4680 polymorphism of COMT has been associated with a number of disorders. In addition, this polymorphism has been found to have important differences in frequency according to the studied population. Therefore, the aim of the present study was to evaluate the frequency of a common single nucleotide polymorphism (SNP) Val108/158Met of the COMT gene in the Mexican population. Accordingly, we recruited 431 healthy volunteers. Our sample consisted of 111 healthy individuals from Mexico City and 320 individuals from the state of Tabasco, Mexico. We observed that Met was the most common allele, ranging from 57% (Tabasco) to 85% (Mexico City). In addition, we analyzed the frequency of Val108/158Met polymorphism of Caucasian (54% Met allele), Asian (29% Met allele) and African (34% Met allele) populations separately and also in comparison with Mexican (63% Met allele) population. In conclusion, the distribution of the Val108/158Met polymorphism distinguishes the Mexican population studied from other populations, but it is necessary to increase the size of the sample to get more conclusive results.

  18. Differential Association of the COMT Val158Met Polymorphism with Clinical Phenotypes in Schizophrenia and Bipolar Disorder

    OpenAIRE

    Goghari, Vina M.; Sponheim, Scott R.

    2008-01-01

    Schizophrenia and bipolar disorder, although diagnostically separate, likely share elements of their genetic etiology. This study assessed whether COMT Val158Met polymorphism has shared or specific associations with clinical phenotypes evident in schizophrenia and bipolar disorder. Schizophrenia and bipolar patients completed a clinical assessment encompassing premorbid functioning and current and lifetime symptomatology. Multivariate analyses yielded a three-way interaction of diagnosis, COM...

  19. Identification and structure of yrast levels in the N = 89 odd-odd /sup 158/Tm nucleus

    Energy Technology Data Exchange (ETDEWEB)

    Drissi, S.; Andre, S.; Genevey, J.; Barci, V.; Gizon, A.; Gizon, J.; Pinston, J.A.; Jastrzebski, J.; Kossakowski, R.; Preibisz, Z.

    1981-10-01

    Excited levels have been identified in the odd-odd /sup 158/Tm nucleus produced in the /sup 150/Sm (/sup 14/N,6n) reaction. The observed level structure based on an isomeric state (Tsub(1/2) = 16 +- 4 ns) is interpreted as a rotational aligned band.

  20. Influence of COMT val158met Genotype on the Depressed Brain during Emotional Processing and Working Memory

    NARCIS (Netherlands)

    Opmeer, Esther M.; Kortekaas, Rudie; van Tol, Marie-Jose; van der Wee, Nic J. A.; Woudstra, Saskia; van Buchem, Mark A.; Penninx, Brenda W.; Veltman, Dick J.; Aleman, Andre

    2013-01-01

    Major depressive disorder (MDD) has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT) gene has been shown to influence prefrontal cortex (PFC) activation during both emot

  1. Effect of COMT Val158Met polymorphism on personality traits and educational attainment in a longitudinal population representative study.

    Science.gov (United States)

    Lehto, K; Akkermann, K; Parik, J; Veidebaum, T; Harro, J

    2013-10-01

    The COMT Val158Met polymorphism has been associated with anxiety and affective disorders, but its effect on anxiety-related personality traits varies between studies. Our purpose was to investigate the effect of COMT Val158Met on personality traits from adolescence to young adulthood in a population representative Caucasian birth cohort. Also its association with educational attainment and anxiety and mood disorders by the age 25 were examined. This analysis is based on the older cohort of the Estonian Children Personality Behavior and Health Study (original number of subjects 593). The personality traits were assessed when the participants were 15, 18 and 25 years old. COMT Val158Met had an effect on Neuroticism in females by age 25 (p=0.001, Bonferroni-corrected for five traits), whereas female Val homozygotes scored the highest. In addition, the Conscientiousness scores of subjects with Val/Val genotype were decreasing in time, being the lowest by the age 25 (p=0.006, Bonferroni-corrected for five traits). By the age 25, males with the Val/Met genotype had mainly secondary or vocational education, whereas female heterozygotes mostly had obtained or were obtaining university education. COMT Val158Met was not associated with anxiety or mood disorders in either gender. These results suggest that genes affecting dopamine system are involved in the development of personality traits and contribute to educational attainment.

  2. Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.

    Science.gov (United States)

    Lang, Undine E; Bajbouj, Malek; Bajbouj, Malck; Sander, Thomas; Gallinat, Juergen

    2007-09-01

    The gene encoding cathechol-O-methyltransferase (COMT) contains a common functional missense polymorphism (Val158Met) that regulates dopamine in an allele-dependent manner. A pivotal role of dopamine neurotransmission in the prefrontal cortex has been implicated in drug-seeking behavior and related personality traits, such as sensation seeking, with some evidence for a gender-specific association. Here, we tested the hypothesis that the COMT Val158Met polymorphism modulates the personality dimension, sensation seeking, in a gender-dependent manner. Study sample included 214 male (age 38.1+/-12.6 years) and 218 female (age 36.1+/-13.6 years) healthy volunteers, who were assessed with Zuckerman's sensation-seeking scale and genotyped for the Val158Met polymorphism (dbSNP:rs4680). Univariate analysis of variance showed that the sensation seeking score was significantly affected by a COMT genotype x gender interaction (F=5.330, df=2, p=0.005). The Val158Met polymorphism was associated with the sensation seeking personality trait in women only. The highest scores in the sensation-seeking scale and in three of the four subscales were observed in female subjects with the Val/Val genotype relative to women carrying the Met allele. Our results suggest that high COMT enzyme activity associated with the Val allele predisposes to high sensation seeking scores in female subjects and add to increasing evidence for a gender specific role of COMT in normal and dysfunctional behavior.

  3. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 158B/159A

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States); Walker, Billy Justin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-11-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 158B/159A which were measured by the Radiation Measurements Laboratory (RML).

  4. Catechol-O-methyltransferase Val158met Polymorphism Interacts With Early Experience to Predict Executive Functions in Early Childhood

    Science.gov (United States)

    Blair, Clancy; Sulik, Michael; Willoughby, Michael; Mills-Koonce, Roger; Petrill, Stephen; Bartlett, Christopher; Greenberg, Mark

    2017-01-01

    Numerous studies demonstrate that the Methionine variant of the catechol-O-methyltransferase Val158Met polymorphism, which confers less efficient catabolism of catecholamines, is associated with increased focal activation of prefrontal cortex (PFC) and higher levels of executive function abilities. By and large, however, studies of COMT Val158Met have been conducted with adult samples and do not account for the context in which development is occurring. Effects of early adversity on stress response physiology and the inverted U shape relating catecholamine levels to neural activity in PFC indicate the need to take into account early experience when considering relations between genes such as COMT and executive cognitive ability. Consistent with this neurobiology, we find in a prospective longitudinal sample of children and families (N=1292) that COMT Val158Met interacts with early experience to predict executive function abilities in early childhood. Specifically, the Valine variant of the COMT Val158Met polymorphism, which confers more rather than less efficient catabolism of catecholamines is associated with higher executive function abilities at child ages 48 and 60 months and with faster growth of executive function for children experiencing early adversity, as indexed by cumulative risk factors in the home at child ages 7, 15, 24, and 36 months. Findings indicate the importance of the early environment for the relation between catecholamine genes and developmental outcomes and demonstrate that the genetic moderation of environmental risk is detectable in early childhood. PMID:26251232

  5. Event-by-event charged-neutral fluctuations in Pb plus Pb collisions at 158 A GeV

    NARCIS (Netherlands)

    Aggarwal, M. M.; Ahammed, Z.; Angelis, A. L. S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T. C.; Baba, P. V. K. S.; Badyal, S. K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K. B.; Bhatia, V. S.; Blume, C.; Bucher, D.; Buesching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M. P.; Delagrange, H.; Donni, P.; Majumdar, M. R. Dutta; El Chenawi, K.; Dubey, A. K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M. S.; Garpman, S.; Gavrishchuk, O.; Geurts, F. J. M.; Ghosh, T. K.; Glasow, R.; Gupta, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H. H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpios, K.; Kolb, B. W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Liu, H.; Löhner, H.; Luquin, L.; Mahapatra, D. P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G. C.; Mohanty, B.; Mora, M. -J.; Morrison, D.; Moukhanova, T.; Mukhopadhyay, D. S.; Naef, H.; Nandi, B. K.; Nayak, S. K.; Nayak, T. K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Pavliouk, S.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Pinanaud, W.; Plasil, F.; Purschke, M. L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N. K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J. M.; Sambyal, S. S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H. -R.; Schutz, Y.; Shabratova, G.; Shah, T. H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B. C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S. P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; Pijll, E. C. V. D.; Eijndhoven, N. V.; Nieuwenhuizen, G. J. V.; Vinogradov, A.; Viyogi, Y. P.; Vodopianov, A.; Voeroes, S.; Wyslouch, B.; Young, G. R.

    2011-01-01

    Charged particles and photons have been measured in central Pb + Pb collisions at 158 A GeV in a common (eta-phi)-phase space region in the WA98 experiment at the CERN SPS. The measured distributions have been analyzed to quantify the frequency with which phase space regions of varying sizes have

  6. Centrality dependence of charged-neutral particle fluctuations in 158A (GeVPb)-Pb-208+Pb-208 collisions

    NARCIS (Netherlands)

    Aggarwal, MM; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Bathe, S; Batiounia, B; Bernier, T; Bhalla, KB; Bhatia, VS; Blume, C; Bucher, D; Busching, H; Carlen, L; Chattopadhyay, S; Decowski, MP; Delagrange, H; Donni, P; Majumdar, MRD; El Chenawi, K; Dubey, AK; Enosawa, K; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Karadjev, K; Karpio, K; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Lohner, H; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Miake, Y; Mishra, GC; Mohanty, B; Mora, MJ; Morrison, D; Mukhanova, T; Mukhopadhyay, DS; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Peressounko, D; Petracek, [No Value; Pinganaud, W; Plasil, F; Purschke, ML; Rak, J; Raniwala, R; Raniwala, S; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Sood, G; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A.; Tykarski, L; von der Pijll, EC; von Eijndhoven, N; von Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Young, GR

    Results on the study of localized fluctuations in the multiplicity of charged particles and photons produced in 158A GeV/c Pb+Pb collisions are presented for varying centralities. The charged versus neutral particle multiplicity correlations in common phase space regions of varying azimuthal sizes

  7. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158met polymorphism.

    Directory of Open Access Journals (Sweden)

    Karin B Jensen

    Full Text Available Increased pain sensitivity after opioid administration (opioid-induced hyperalgesia and/or repeated painful stimuli is an individually varying and clinically important phenomenon. The functional polymorphism (val(158met of the Catechol-O-methyltransferase (COMT gene regulates the metabolism of dopamine/noradrenaline. Individuals homozygous for the met(158 allele have been reported to have increased pain sensitivity and there are findings of lower micro-opioid system activation during sustained pain. We hypothesized that met/met individuals would exhibit higher pain sensitization and opioid-induced hyperalgesia in response to repeated pain stimuli and an intravenous injection of an opioid drug. Participants were 43 healthy subjects who went through an experiment where five blocks of pain were induced to the hand using a heat probe. After each stimulus subjects rated the pain on a visual analogue scale (VAS from 0 mm (no pain to 100 mm (worst possible pain. Before the second stimulus there was an intravenous injection of a rapid and potent opioid drug. At baseline there was no difference in pain ratings between the COMTval(158met genotypes, F(2, 39<1. However, a repeated measures ANOVA for all five stimuli revealed a main effect for COMTval(158met genotype, F(2, 36 = 4.17, p = 0.024. Met/met individuals reported significantly more pain compared to val/val, p = 0.010. A pairwise comparison of baseline and the opioid intervention demonstrated that analgesia was induced in all groups (p = 0.042 without a separating effect for genotype (n.s. We suggest that the initial response of the descending pain system is not influenced by the COMTval(158met polymorphism but when the system is challenged the difference is revealed. An important clinical implication of this may be that the COMTval(158met related differences may be more expressed in individuals where the inhibitory system is already challenged and sensitive, e.g. chronic pain patients. This has to

  8. Association of Catechol-O-methyltransferase polymorphism Val158Met and mammographic density: A meta-analysis.

    Science.gov (United States)

    Kallionpää, Roope A; Uusitalo, Elina; Peltonen, Juha

    2017-08-15

    The Val158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Val158Met polymorphism on mammographic density. Original studies reporting data on mammographic density, stratified by the presence of COMT Val158Met polymorphism, were identified and combined using genetic models Met/Val vs. Val/Val, Met/Met vs. Val/Val, Val/Met+Met/Met vs. Val/Val (dominant model) and Met/Met vs. Val/Met+Val/Val (recessive model). Subgroup analyses by breast cancer status, menopausal status and use of hormone replacement therapy (HRT) were also performed. Eight studies were included in the meta-analysis. The overall effect in percent mammographic density was -1.41 (CI -2.86 to 0.05; P=0.06) in the recessive model. Exclusion of breast cancer patients increased the effect size to -1.93 (CI -3.49 to -0.37; P=0.02). The results suggested opposite effect of COMT Val158Met for postmenopausal users of HRT versus premenopausal women or postmenopausal non-users of HRT. COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Globules and pillars seen in the [CII] 158 micron line with SOFIA

    CERN Document Server

    Schneider, N; Tremblin, P; Hennemann, M; Minier, V; Hill, T; Comerón, F; Requena-Torres, M A; Kraemer, K E; Simon, R; Röllig, M; Stutzki, J; Djupvik, A A; Zinnecker, H; Marston, A; Csengeri, T; Cormier, D; Lebouteiller, V; Audit, E; Motte, F; Bontemps, S; Sandell, G; Allen, L; Megeath, T; Gutermuth, R A

    2012-01-01

    Molecular globules and pillars are spectacular features, found only in the interface region between a molecular cloud and an HII-region. Impacting Far-ultraviolet (FUV) radiation creates photon dominated regions (PDRs) on their surfaces that can be traced by typical cooling lines. With the GREAT receiver onboard SOFIA we mapped and spectrally resolved the [CII] 158 micron atomic fine-structure line and the highly excited 12CO J=11-10 molecular line from three objects in Cygnus X (a pillar, a globule, and a strong IRAS source). We focus here on the globule and compare our data with existing Spitzer data and recent Herschel Open-Time PACS data. Extended [CII] emission and more compact CO-emission was found in the globule. We ascribe this emission mainly to an internal PDR, created by a possibly embedded star-cluster with at least one early B-star. However, external PDR emission caused by the excitation by the Cyg OB2 association cannot be fully excluded. The velocity-resolved [CII] emission traces the emission ...

  10. Topological Model for the Search of New Antibacterial Drugs. 158 Theoretical Candidates.

    Science.gov (United States)

    Bueso-Bordils, Jose I; Aleman, Pedro A; Zamora, Luis Lahuerta; Martin-Algarra, Rafael; Duart, Maria J; Antón-Fos, Gerardo M

    2015-01-01

    In this paper, molecular topology was used to develop a mathematical model capable of classifying compounds according to their antibacterial activity. Topological indices were used as structural descriptors and their relation to antibacterial activity was determined by applying linear discriminant analysis (LDA) on a group of quinolones, widely used nowadays because of their broad spectrum of activity, well tolerance profile and advantageous pharmacokinetic properties. The topological model of activity obtained included two discriminant functions, selected by a combination of various statistical paremeters such as Fisher-Snedecor F and Wilk's lambda, and allows the reliable prediction of antibacterial activity in any organic compound. After a virtual pharmacological screening on a library of 6375 compounds, the model has selected 263 as active compounds, from which 40% have proven antibacterial activity. The results obtained clearly reveal the high efficiency of molecular topology for the prediction of pharmacological activities. These models are very helpful in the discovery of new applications of natural and synthetic molecules with different chemical or biological properties. Therefore, we finally present 158 strong candidates to be developed as novel antibacterials.

  11. A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Jay P Singh

    Full Text Available We conducted a meta-analysis of studies examining the association between the Val158Met COMT polymorphism and violence against others in schizophrenia. A systematic search current to November 1, 2011 was conducted using MEDLINE, EMBASE, CINAHL, PsycINFO, ProQuest, and the National Criminal Justice Reference Service and identified 15 studies comprising 2,370 individuals with schizophrenia for inclusion. Bivariate analyses of study sensitivities and specificities were conducted. This methodology allowed for the calculation of pooled diagnostic odds ratios (DOR. Evidence of a significant association between the presence of a Met allele and violence was found such that men's violence risk increased by approximately 50% for those with at least one Met allele compared with homozygous Val individuals (DOR = 1.45; 95% CI = 1.05-2.00; z = 2.37, p = 0.02. No significant association between the presence of a Met allele and violence was found for women or when outcome was restricted to homicide. We conclude that male schizophrenia patients who carry the low activity Met allele in the COMT gene are at a modestly elevated risk of violence. This finding has potential implications for the pharmacogenetics of violent behavior in schizophrenia.

  12. Strange particle production in proton-proton collisions at 158 GeV

    CERN Document Server

    Barna, Daniel

    A new experimen tal procedure to reconstruct neutral strange particles (so-called V 0 s, like §, §) and multiply strange particles ( cascades , like • ° and ≠ ° ) in the NA49 experimen t at the CERN SPS is presen ted in this thesis, together with the results obtained by this metho d in proton-proton collisions at 158 GeV beam energy . The NA49 experimen t, its detector system and reconstruction software is brie∞y describ ed. The way from the detector signals to reconstructed particle trajectories is ex- plained, with special emphasis on V 0 and cascade reconstruction. The newly developed procedure is presen ted together with another metho d. These two metho ds are com- pared, and their performance is studied in detail. Argumen ts for the need of the newly developed procedure (and for the need of two indep enden t metho ds) are given. The results of my work, presen ted in this thesis (obtained by combining the results of the two separate metho ds) are as follows: ≤ Inclusiv e longitudinal and tran...

  13. Catechol-O-methyltransferase val158met Polymorphism Interacts with Sex to Affect Face Recognition Ability

    Science.gov (United States)

    Lamb, Yvette N.; McKay, Nicole S.; Singh, Shrimal S.; Waldie, Karen E.; Kirk, Ian J.

    2016-01-01

    The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implicated in face recognition, a form of cognition for which a female advantage has typically been reported. This study aimed to investigate potential joint effects of sex and COMT genotype on face recognition. A sample of 142 university students was genotyped and assessed using the Faces I subtest of the Wechsler Memory Scale – Third Edition (WMS-III). A significant two-way interaction between sex and COMT genotype on face recognition performance was found. Of the male participants, COMT val homozygotes and heterozygotes had significantly lower scores than met homozygotes. Scores did not differ between genotypes for female participants. While male val homozygotes had significantly lower scores than female val homozygotes, no sex differences were observed in the heterozygotes and met homozygotes. This study contributes to the accumulating literature documenting sex-specific effects of the COMT polymorphism by demonstrating a COMT-sex interaction for face recognition, and is consistent with a role for dopamine in face recognition. PMID:27445927

  14. Catechol-O-methyltransferase val(158)met Polymorphism Interacts with Sex to Affect Face Recognition Ability.

    Science.gov (United States)

    Lamb, Yvette N; McKay, Nicole S; Singh, Shrimal S; Waldie, Karen E; Kirk, Ian J

    2016-01-01

    The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implicated in face recognition, a form of cognition for which a female advantage has typically been reported. This study aimed to investigate potential joint effects of sex and COMT genotype on face recognition. A sample of 142 university students was genotyped and assessed using the Faces I subtest of the Wechsler Memory Scale - Third Edition (WMS-III). A significant two-way interaction between sex and COMT genotype on face recognition performance was found. Of the male participants, COMT val homozygotes and heterozygotes had significantly lower scores than met homozygotes. Scores did not differ between genotypes for female participants. While male val homozygotes had significantly lower scores than female val homozygotes, no sex differences were observed in the heterozygotes and met homozygotes. This study contributes to the accumulating literature documenting sex-specific effects of the COMT polymorphism by demonstrating a COMT-sex interaction for face recognition, and is consistent with a role for dopamine in face recognition.

  15. Electron-Pair Production in 158 AGeV/c Pb-Au Collisions from CERES

    CERN Document Server

    Yurevich, Sergey

    2006-01-01

    The CERES experiment is devoted to the measurement of low-mass electron pairs in proton and ion-induced collisions at the Super Proton Synchrotron accelerator. The main goal of the CERES experiment is to investigate modifications of hadron properties in hot and dense nuclear matter. A significant enhancement of dilepton pair yield with respect to expectations based on hadron decays was observed in the mass range 0.25 m 0.7 GeV/c. This fascinating result can only be described by models invoking in-medium modifications of the meson. To distinguish between different theoretical explanations of the enhancement the experiment was upgraded in 1998 by the addition of a radial TPC to improve the mass resolution in the vector meson region. In this thesis, the analysis of the data sample taken in 2000 in 158 A GeV/c Pb-Au collisions with the upgraded experimental setup is presented. The observed enhancement of the pairs confirms previous results of CERES. The data, compared to the theoretical calculations based on drop...

  16. Centrality and system size dependence of multiplicity fluctuations in nuclear collisions at 158 AGeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, J; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Flierl, D; Fodor, Z; Foka, P; Friese, V; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Gál, J; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Laszlo, A; Litov, L; Lungwitz, B; Lévai, Peter; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Nicolic, V; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Prindle, D; Pálla, G; Pühlhofer, F; Renfordt, R; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Schuster, T; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Strabel, C; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Szymanski, P; Trubnikov, V; Van Leeuwen, M; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zimányi, J

    2007-01-01

    The centrality and system size dependence of multiplicity fluctuations of charged particles produced in nuclear collisions at 158 AGeV was studied by the NA49 collaboration. Centrality selected Pb+Pb collisions, semi-central C+C and Si+Si collisions as well as inelastic p+p interactions were analyzed. The number of projectile participants determined on event-by-event basis was used to characterize the collision centrality. The scaled variance of the multiplicity distribution obtained in the forward rapidity region (1.1

  17. Traumatic peripheral nerve injuries: epidemiological findings, neuropathic pain and quality of life in 158 patients.

    Science.gov (United States)

    Ciaramitaro, Palma; Mondelli, Mauro; Logullo, Francesco; Grimaldi, Serena; Battiston, Bruno; Sard, Arman; Scarinzi, Cecilia; Migliaretti, Giuseppe; Faccani, Giuliano; Cocito, Dario

    2010-06-01

    The objectives of this study were (1) epidemiological analysis of traumatic peripheral nerve injuries; (2) assessment of neuropathic pain and quality of life in patients affected by traumatic neuropathies. All consecutive patients with a diagnosis of traumatic neuropathies from four Italian centres were enrolled. Electromyography confirmed clinical level and site diagnosis of peripheral nerve injury. All patients were evaluated by disability scales, pain screening tools, and quality of life tests. 158 consecutive patients for a total of 211 traumatic neuropathies were analysed. The brachial plexus was a frequent site of traumatic injury (36%) and the radial, ulnar, and peroneal were the most commonly involved nerves with 15% of iatrogenic injuries. Seventy-two percent of the traumatic neuropathies were painful. Pain was present in 66% and neuropathic pain in 50% of all patients. Patients had worse quality of life scores than did the healthy Italian population. Moreover, there was a strong correlation between the quality of life and the severity of the pain, particularly neuropathic pain (Short Form-36 [SF-36] p < 0.005; Beck Depression Inventory [BDI] p < 0.0001). Traumatic neuropathies were more frequent in young males after road accidents, mainly in the upper limbs. Severe neuropathic pain and not only disability contributed to worsening the quality of life in patients with traumatic neuropathies.

  18. Charged pion production in fixed-target Pb + Pb collisions at 158 GeV/nucleon

    Science.gov (United States)

    NA52 Collaboration; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Bohm, C.; Borer, K.; Bussière, A.; Dittus, F.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Hess, P.; Kabana, S.; Klingenberg, R.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Selldén, B.; Stoffel, F.; Weber, M.; Zhang, Q. P.

    1999-12-01

    Changes in pion production as a function of the impact parameter of the collision or the incident energy, may reveal characteristics of a possible first-order phase transition from nuclear to quark matter, as predicted by lattice quantum chromodynamics. In this paper we investigate charged pion production in Pb+Pb collisions at 158 GeV/nucleon near 0° production angle and at forward rapidity (4.3≤ y≤ 6.3). The centrality dependence of pion production is shown in the impact parameter range ~ 2-12 fm at the rapidities y = 5.7 and 6.3. An enhancement in the π-π+ ratio has been measured near beam rapidity, indicating Coulomb interaction of charged pions with the spectator protons. The charged pion yield per nucleon participating in the collision (Np) at y = 5.7 increases faster than linearly with Np, up to Np~100 and then it saturates, while at y = 6.3 it does not exhibit any sudden change as a function of Np.

  19. Measurement of open charm in 158-AGeV/c Pb - Au collisions

    CERN Document Server

    Ludolphs, Wilrid

    This thesis presents a measurement of an upper limit for the open charm yield in 158 AGeV/c Pb-Au collisions with the CERES spectrometer at 7% centrality. A secondary particle reconstruction scheme, based on the reconstruction of the decay vertex, is developed and tested using the decay K0short -> Pi+ Pi- as a reference measurement. An integrated K0short rapidity density of dN/dy = 19.75 +- 0.23(stat) +- 1.70(syst) is measured in the rapidity region 2.0 K+ Pi- requires careful study of the combinatorial background and resonances contributing to the invariant mass spectrum. An open charm enhancement of more than a factor 22 can be excluded at 98% confidence level. The enhancement is calculated with respect to the expected open charm yield in nucleus-nucleus collisions of = 0.21 per event, obtained by scaling the charm cross-section in proton-proton collisions with the number of binary collisions. The first part of this thesis is devoted to the development of a hit finding algorithm for the CERES TPC. Further...

  20. Radionuclide Bone Imaging Features of Bone Metastasis from 158 Patients of Esophageal Cancer%158例食管癌骨转移核素骨显像特征分析

    Institute of Scientific and Technical Information of China (English)

    丁忠旗; 张俊; 盛强; 姚圣华; 骆佩芳

    2012-01-01

    目的探讨食管癌骨转移患者的核素骨显像特征及临床应用。方法收集我院2007年1月至2011年12月接受全身骨显像的158例食管癌患者病历资料。对全身骨显像结果进行统计和分析,归纳食管癌患者骨转移显像特点。结果 158例食管癌患者骨转移发生率为17.72%(28/158),其中以脊柱及肋骨转移最为多见,发生率分别为89.29%(25/28),64.29%(18/28)。依据病理类型,鳞癌、腺癌、小细胞癌的骨转移发生率分别为13.83%(13/94),21.95%(9/41)和26.09%(6/23)。结论放射性核素骨显像对食管癌患者具有重要的临床意义,应作为治疗前后骨转移诊断和随访的常规检查手段。%Objective To investigate radionuclide bone imaging features and its clinical value in esophageal cancer patients with bone metastasis.Methods The medical records of 158 patients with esophageal cancer who accepted the whole body bone scan(WBS) from January 2007 to December 2011 in our hospital were collected.The WBS results were statistically analyzed,and the imaging features were summarized.Results The bone metastasis incidence of 158 cases of esophageal cancer patients was 17.72%(28/158).The spine and rib metastasis were the most common,the rate was 89.29%(25/28) and 64.29%(18/28),respectively.According to the pathological type,the bone metastasis incidence of squamous cell carcinoma,adenocarcinoma,small cell carcinoma was 13.83%(13/94),21.95%(9/41) and 26.09%(6/23),respectively.Conclusion Radionuclide bone imaging has important clinical value in patients with esophageal cancer.It should serve as a routine means of diagnosis and follow-up of bone metastases before or after treatment of patients.

  1. 158A GeV/c Pb+Pb碰撞可能有QGP的一旁证%A Circumstantial Evidence for the Possible Production of QGP in the 158A GeV/c Central Pb+Pb Collisions

    Institute of Scientific and Technical Information of China (English)

    刘志毅; 萨本豪; 周书华

    2001-01-01

    用不含QGP假设的强子和弦级联模型(JPCIAE),研究了CERN WA98实验组新近发表的158A GeV/c Pb+Pb中心碰撞中直接光子和π0粒子的横动量分布:两者的理论结果均一致的低于实验值. 联系到JPCIAE能成功解释无直接光子超出确切迹象的WA80和WA93对200A GeV/c S+Au中心碰撞测量得出的结果:因而为158A GeV/c Pb+Pb中心碰撞中可能有QGP生成提供了一个旁证.

  2. Clinical research on the antenatal hemorrhage of placenta previa of 158 patients in the later stages of pregnancy%158例孕晚期前置胎盘出血的临床分析

    Institute of Scientific and Technical Information of China (English)

    李艳

    2011-01-01

    Objective: To explore the related factors and emergency treatment of antenatal hemorrhage of placenta previa. Methods: 158 patients diagnosed as antenatal hemorrhage of placenta previa were analyzed retrospectively. Results: Of all the 158 patients, 147 patients (93.04%) performed cesarean section, and the other 11 cases (6.96%) performed vaginal delivery. All newborns including 7 cases of suffocation newboms (one was a severe suffocation case) had good prognosis except one death. 2 patients were performed hysterectomy for postpartum hemorrhage (one for placenta accreta), and the others were safe. Conclusion: Cesarean section is a main means to treat antenatal hemorrhage of placenta previa in the later stages of pregnancy, and can guarantee mothers and infants security to greatest extent.%目的:探讨前置胎盘产前大出血的相关因素,总结紧急处理措施.方法:对诊断前置胎盘出血158例患者进行回顾性分析.结果:剖宫产术147例(93.04%),阴道分娩11例(6.96%).158例中1例死胎,新生儿窒息7例(重度窒息1例),新生儿预后均良好.2例因产后大出血切除子宫(其中1例为胎盘植入),其余均母婴安全.结论:剖宫产术是处理晚孕期前置胎盘大出血的主要手段,可以最大限度地保证母婴安全.

  3. Xining Area 158 Examples Pulmonary Tuberculoses Clinical and X Characteristic Analysis%西宁地区158例肺结核临床与X线的特征分析

    Institute of Scientific and Technical Information of China (English)

    王小义

    2009-01-01

    目的:本文通过进一步对西宁地区158例老年肺结核影像特点及诊断探讨.方法:采用我院LDRD型数字化低剂量医用诊断DRX射线机照射,对158例肺结核临床表现进行分析.结果:西宁地区158例老年肺结核病变以两肺分布多见,病变范围广泛、病变多以渗出增殖及纤维空洞为主、并发症较多.结论:老年肺结核诊断中应注意与肺部炎症、矽肺、肺癌等鉴别、X线诊断肺结核病仍然是最常用的方法.

  4. Production of neutral pions Pb+Au collisions at 158 AGeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Soualah, Rachik

    2009-06-24

    The direct photons are a particularly useful probe to search for an evidence of the Quark-Gluon Plasma formation in ultra-relativistic heavy-ion collisions. Direct photons can be extracted experimentally by measuring the large background from {pi}{sup 0} and {eta} meson decays. This thesis work represents the production of the neutral pion mesons measured with the CERES/NA45 experiment at the top SPS energy in 158 AGeV/c Pb-Au collisions. The {pi}{sup 0} {yields} {gamma}{gamma} (98.8%) is the decay channel used in the reconstruction scheme. The {pi}{sup 0} measurement is based on the data taken in the year 2000. The CERES experiment can measure the photons that convert shortly before the TPC by measuring the e{sup +}e{sup -} pairs in the TPC. The RICH2 mirror is the main converter used for this analysis. The presented analysis method describes in more details the selection of the e{sup +} and e{sup -} tracks using only the TPC information to reconstruct the converted photon. A Secondary vertex technique was developed and used to select the photons converted in the RICH2 mirror area. The extraction of the {pi}{sup 0} needs a careful study of the combinatorial background determined using the mixed event technique. The obtained invariant mass distribution of the two photons defined well the {pi}{sup 0} peak. The neutral pion transverse spectra compared to phenomenological models and other experiments validate our analysis method. (orig.)

  5. The interaction of early life experiences with COMT val158met affects anxiety sensitivity.

    Science.gov (United States)

    Baumann, C; Klauke, B; Weber, H; Domschke, K; Zwanzger, P; Pauli, P; Deckert, J; Reif, A

    2013-11-01

    The pathogenesis of anxiety disorders is considered to be multifactorial with a complex interaction of genetic factors and individual environmental factors. Therefore, the aim of this study was to examine gene-by-environment interactions of the genes coding for catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA) with life events on measures related to anxiety. A sample of healthy subjects (N = 782; thereof 531 women; mean age M = 24.79, SD = 6.02) was genotyped for COMT rs4680 and MAOA-uVNTR (upstream variable number of tandem repeats), and was assessed for childhood adversities [Childhood Trauma Questionnaire (CTQ)], anxiety sensitivity [Anxiety Sensitivity Index (ASI)] and anxious apprehension [Penn State Worry Questionnaire (PSWQ)]. Main and interaction effects of genotype, environment and gender on measures related to anxiety were assessed by means of regression analyses. Association analysis showed no main gene effect on either questionnaire score. A significant interactive effect of childhood adversities and COMT genotype was observed: Homozygosity for the low-active met allele and high CTQ scores was associated with a significant increment of explained ASI variance [R(2) = 0.040, false discovery rate (FDR) corrected P = 0.04]. A borderline interactive effect with respect to MAOA-uVNTR was restricted to the male subgroup. Carriers of the low-active MAOA allele who reported more aversive experiences in childhood exhibited a trend for enhanced anxious apprehension (R(2) = 0.077, FDR corrected P = 0.10). Early aversive life experiences therefore might increase the vulnerability to anxiety disorders in the presence of homozygosity for the COMT 158met allele or low-active MAOA-uVNTR alleles.

  6. Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.

    Science.gov (United States)

    Rissling, Ida; Frauscher, Birgit; Kronenberg, Florian; Tafti, Mehdi; Stiasny-Kolster, Karin; Robyr, Anne-Catherine; Körner, Yvonne; Oertel, Wolfgang Hermann; Poewe, Werner; Högl, Birgit; Möller, Jens Carsten

    2006-01-01

    A preliminary study by our group suggested an association between daytime sleepiness and the catechol-O-methyltransferase (COMT) val158met polymorphism (rs4680) in patients with Parkinson disease (PD). We sought to confirm this association in a large group of patients with PD. Genetic association study in patients with PD. Movement disorder sections at 2 university hospitals. PD patients with and without episodes of suddenly falling asleep matched for antiparkinsonian medication, disease duration, sex, and age, who participated in a previous genetic study on dopamine-receptor polymorphisms. Not applicable. In this study, 240 patients with PD (154 men; age 65.1 +/- 6.1 years; disease duration 9.4 +/- 6.0 years) were included. Seventy had the met-met (LL), 116 the met-val (LH), and 54 the val-val (HH) genotype. In the combined LL+LH group (featuring reduced COMT activity), the mean Epworth Sleepiness Scale (ESS) score was 9.0 +/- 5.9 versus 11.0 +/- 6.1 in the HH (high COMT activity) group (P = .047). Forty-seven percent of the LL and LH patients had sudden sleep onset compared with 61% of the HH patients (P = .07). Logistic regression, however, showed that both pathologic ESS scores (i.e., > 10) and sudden sleep onset were predicted by subjective disease severity (P < .001 each) but not by the COMT genotype. Our previous finding that the L-allele may be associated with daytime sleepiness could not be confirmed in the present study. Altogether, our data do not support a clinically relevant effect of the COMT genotype on daytime sleepiness in PD.

  7. Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood.

    Science.gov (United States)

    Boecker-Schlier, Regina; Holz, Nathalie E; Buchmann, Arlette F; Blomeyer, Dorothea; Plichta, Michael M; Jennen-Steinmetz, Christine; Wolf, Isabella; Baumeister, Sarah; Treutlein, Jens; Rietschel, Marcella; Meyer-Lindenberg, Andreas; Banaschewski, Tobias; Brandeis, Daniel; Laucht, Manfred

    2016-05-15

    Accumulating evidence suggests that altered dopamine transmission may increase the risk of mental disorders such as ADHD, schizophrenia or depression, possibly mediated by reward system dysfunction. This study aimed to clarify the impact of the COMT Val(158)Met polymorphism in interaction with environmental variation (G×E) on neuronal activity during reward processing. 168 healthy young adults from a prospective study conducted over 25years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. DNA was genotyped for COMT, and childhood family adversity (CFA) up to age 11 was assessed by a standardized parent interview. At reward delivery, a G×E revealed that fMRI activation for win vs. no-win trials in reward-related regions increased with the level of CFA in Met homozygotes as compared to Val/Met heterozygotes and Val homozygotes, who showed no significant effect. During the anticipation of monetary vs. verbal rewards, activation decreased with the level of CFA, which was also observed for EEG, in which the CNV declined with the level of CFA. These results identify convergent genetic and environmental effects on reward processing in a prospective study. Moreover, G×E effects during reward delivery suggest that stress during childhood is associated with higher reward sensitivity and reduced efficiency in processing rewarding stimuli in genetically at-risk individuals. Together with previous evidence, these results begin to define a specific system mediating interacting effects of early environmental and genetic risk factors, which may be targeted by early intervention and prevention. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Are Mechanistic and Statistical QSAR Approaches Really Different? MLR Studies on 158 Cycloalkyl-Pyranones.

    Science.gov (United States)

    Bhhatarai, Barun; Garg, Rajni; Gramatica, Paola

    2010-07-12

    Two parallel approaches for quantitative structure-activity relationships (QSAR) are predominant in literature, one guided by mechanistic methods (including read-across) and another by the use of statistical methods. To bridge the gap between these two approaches and to verify their main differences, a comparative study of mechanistically relevant and statistically relevant QSAR models, developed on a case study of 158 cycloalkyl-pyranones, biologically active on inhibition (Ki ) of HIV protease, was performed. Firstly, Multiple Linear Regression (MLR) based models were developed starting from a limited amount of molecular descriptors which were widely proven to have mechanistic interpretation. Then robust and predictive MLR models were developed on the same set using two different statistical approaches unbiased of input descriptors. Development of models based on Statistical I method was guided by stepwise addition of descriptors while Genetic Algorithm based selection of descriptors was used for the Statistical II. Internal validation, the standard error of the estimate, and Fisher's significance test were performed for both the statistical models. In addition, external validation was performed for Statistical II model, and Applicability Domain was verified as normally practiced in this approach. The relationships between the activity and the important descriptors selected in all the models were analyzed and compared. It is concluded that, despite the different type and number of input descriptors, and the applied descriptor selection tools or the algorithms used for developing the final model, the mechanistical and statistical approach are comparable to each other in terms of quality and also for mechanistic interpretability of modelling descriptors. Agreement can be observed between these two approaches and the better result could be a consensus prediction from both the models. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Prevalence of Back Problems in 1069 Adults With Idiopathic Scoliosis and 158 Adults Without Scoliosis.

    Science.gov (United States)

    Grauers, A; Topalis, C; Möller, H; Normelli, H; Karlsson, Mk; Danielsson, A; Gerdhem, P

    2014-04-08

    Study Design. Multi-center case-control studyObjective. To investigate the prevalence of back problems in adults with idiopathic scoliosis.Summary of Background Data. Information on the prevalence of back problems in adults with idiopathic scoliosis is scarce, especially in untreated individuals, males and individuals with an age at onset of the scoliosis of less than 10 years.Methods. 1069 individuals with idiopathic scoliosis and 158 individuals without scoliosis, all aged 20-65 years, answered a questionnaire on back problems. Individuals with scoliosis were diagnosed between ages 4 and 20 years and any treatment was terminated before age 20. Logistic regression or ANCOVA was used for group comparisons.Results. Mean (SD) age at the time of investigation in individuals with scoliosis (123 men and 946 women) was 41 (9) years, and in individuals without scoliosis (75 men and 83 women) 45 (13) years. 374 individuals with scoliosis were untreated, 451 had been brace treated and 244 surgically treated. The mean prevalence of back problems was 64% in the individuals with scoliosis and 29% in the individuals without scoliosis (pscoliosis, 69% reported back problems, among the brace treated 61%, and among the surgically treated 64% (p = 0.06). When comparing females and males with scoliosis, and individuals with juvenile and adolescent scoliosis, there were no statistically significant differences in the prevalence of back problems (p = 0.10 and p = 0.23, respectively).Conclusion. Adults with idiopathic scoliosis have a higher prevalence of back problems than individuals without scoliosis. Treatment, gender and juvenile or adolescent onset of diagnosis was not related to the prevalence of back problems in adulthood.

  10. Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway.

    Science.gov (United States)

    Kee, Hae Jin; Cho, Soo-Na; Kim, Gwi Ran; Choi, Sin Young; Ryu, Yuhee; Kim, In Kyeom; Hong, Young Joon; Park, Hyung Wook; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Jeong, Myung Ho

    2014-11-01

    Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism. Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway.

  11. Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder.

    Science.gov (United States)

    Goghari, Vina M; Sponheim, Scott R

    2008-08-01

    Schizophrenia and bipolar disorder, although diagnostically separate, likely share elements of their genetic etiology. This study assessed whether the COMT Val158Met polymorphism has shared or specific associations with clinical phenotypes evident in schizophrenia and bipolar disorder. Schizophrenia and bipolar patients completed a clinical assessment encompassing premorbid functioning and current and lifetime symptomatology. Multivariate analyses yielded a three-way interaction of diagnosis, COMT genotype for lifetime symptomatology. The COMT Val allele was associated with greater positive symptomatology in schizophrenia, whereas Met homozygosity was associated with greater positive symptomatology in bipolar disorder. Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder. Lifetime symptomatology may be particularly useful in determining the relationship between genes and clinical phenotypes across mental disorders.

  12. Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder.

    Science.gov (United States)

    Armagan, E; Almacıoglu, M L; Yakut, T; Köse, A; Karkucak, M; Köksal, O; Görükmez, O

    2013-03-19

    Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.

  13. Deuteron and triton production in Pb+Pb collisions at 158 A centre dot GeV.

    CERN Document Server

    Hansen, A G; Bøggild, H; Boissevain, J G; Conin, L; Christiansen, P; Dodd, J; Erazmus, B; Esumi, S; Fabjan, Christian Wolfgang; Ferenc, D; Fields, D E; Franz, A; Gaardhøje, J J; Hansen, A G; Hansen, O; Hardtke, D; Hecke, H V; Holzer, E B; Humanic, T J; Hummel, P; Jacak, B V; Jayanti, R; Kaimi, K; Kaneta, M; Kohama, T; Kopytine, M; Leltchouk, M; Ljubicic, A; Lörstad, B; Martin, L; Maeda, N; Malina, R; Medvedev, A; Murray, M; Ohnishi, H; Paic, G; Pandey, S U; Piuz, François; Pluta, J; Polychronakos, V; Potekhin, M V; Poulard, G; Reichhold, D M; Sakaguchi, A; Simon-Gillo, J; Schmidt-Sørensen, J; Sondheim, W E; Sugitate, T; Sullivan, J P; Sumi, Y; Willis, W J; Wolf, K L; Xu, N; Zachary, D S

    1999-01-01

    NA44 has measured the invariant cross section of deuterons and tritons at non zero p sub t in 158 A centre dot GeV lead on lead collisions at CERN SPS. Normalized transverse mass spectra and coalescence parameters versus p sub t have been calculated showing a significant transverse flow. Radius parameters have been extracted using a simple thermal coalescence model. Results from RQMD+coalescence calculations are compared to the data.

  14. Body mass index and incident hospitalisation for cardiovascular disease in 158 546 participants from the 45 and Up Study

    OpenAIRE

    Joshy, G; Korda, R J; Attia, J; Liu, B.; Bauman, A E; Banks, E.

    2013-01-01

    Objective: To investigate the relationship between fine gradations in body mass index (BMI) and risk of hospitalisation for different types of cardiovascular disease (CVD). Design, Subjects and Methods: The 45 and Up Study is a large-scale Australian cohort study initiated in 2006. Self-reported data from 158 546 individuals with no history of CVD were linked prospectively to hospitalisation and mortality data. Hazard ratios (HRs) of incident hospitalisation for specific CVD diagnoses in rela...

  15. VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome

    Science.gov (United States)

    del Hoyo, Laura; Xicota, Laura; Langohr, Klaus; Sánchez-Benavides, Gonzalo; de Sola, Susana; Cuenca-Royo, Aida; Rodriguez, Joan; Rodríguez-Morató, Jose; Farré, Magí; Dierssen, Mara; de la Torre, Rafael; Cuenca-Royo, Aida

    2016-01-01

    Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. DS also present a high risk for early onset of Alzheimer Disease-like dementia. The dopamine (DA) system plays a neuromodulatory role in the activity of the PFC. Several studies have implicated trait differences in DA signaling on executive functioning based on genetic polymorphisms in the genes encoding for the catechol-O-methyltransferase (COMTVal158Met) and the dopamine transporter (VNTR-DAT1). Since it is known that the phenotypic consequences of genetic variants are modulated by the genetic background in which they occur, we here explore whether these polymorphisms variants interact with the trisomic genetic background to influence gene expression, and how this in turn mediates DS phenotype variability regarding PFC cognition. We genotyped 69 young adults of both genders with DS, and found that VNTR-DAT1 was in Hardy-Weinberg equilibrium but COMTVal158Met had a reduced frequency of Met allele homozygotes. In our population, genotypes conferring higher DA availability, such as Met allele carriers and VNTR-DAT1 10-repeat allele homozygotes, resulted in improved performance in executive function tasks that require mental flexibility. Met allele carriers showed worse adaptive social skills and self-direction, and increased scores in the social subscale of the Dementia Questionnaire for People with Intellectual Disabilities than Val allele homozygotes. The VNTR-DAT1 was not involved in adaptive behavior or early dementia symptoms. Our results suggest that genetic variants of COMTVal158Met and VNTR-DAT1 may contribute to PFC-dependent cognition, while only COMTVal158Met is involved in behavioral phenotypes of DS, similar to euploid population. PMID:27799900

  16. Enhancement of central $\\Lambda$, $\\Xi$ and $\\Omega$ yields in Pb-Pb collisions at 158 A GeV/c

    CERN Document Server

    Andersen, E; Armenise, N; Bakke, H; Bán, J; Barberis, D; Beker, H; Beusch, Werner; Bloodworth, Ian J; Böhm, J; Caliandro, R; Campbell, M; Cantatore, E; Carrer, N; Catanesi, M G; Chesi, Enrico Guido; Dameri, M; Darbo, G; Diaczek, A; Di Bari, D; Di Liberto, S; Earl, B C; Elia, D; Evans, D; Fanebust, K; Fini, R A; Fontaine, J C; Ftácnik, J; Ghidini, B; Grella, G; Guida, M; Heijne, Erik H M; Helstrup, H; Holme, A K; Huss, D; Jacholkowski, A; Jones, G; Jovanovic, P; Jusko, A; Kachanov, V A; Kachelhoffer, T; Kinson, J B; Kirk, A; Klempt, W; Knudsen, H; Knudson, K P; Králik, I; Lassalle, J C; Lenti, V; Lietava, R; Loconsole, R A; Løvhøiden, G; Lupták, M; Mack, V; Manzari, V; Martinengo, P; Mazzoni, M A; Meddi, F; Michalon, A; Michalon-Mentzer, M E; Middelkamp, P; Morando, M; Muciaccia, M T; Nappi, E; Navach, F; Norman, P I; Osculati, B; Pastircák, B; Pellegrini, F; Píska, K; Posa, F; Quercigh, Emanuele; Ricci, R A; Romano, G; Rosa, G; Rossi, L; Rotscheidt, Herbert; Safarík, K; Saladino, S; Salvo, C; Sándor, L; Scognetti, T; Segato, G F; Sené, M; Sené, R; Simone, S; Singovsky, A V; Snoeys, W; Staroba, P; Szafran, S; Thompson, M; Thorsteinsen, T F; Tomasicchio, G; Torrieri, G D; Tveter, T S; Urbán, J; Vasileiadis, G; Venables, M; Villalobos Baillie, O; Virgili, T; Volte, A; Votruba, M F; Závada, P

    1998-01-01

    $\\Lambda$, $\\Xi$ and $\\Omega$ yields and transverse mass spectra have been measured at central rapidity in Pb-Pb and p-Pb collisions at 158~A~GeV/$c$. The yields in Pb-Pb interactions are presente d as a function of the collision centrality and compared with those obtained from p-Pb collisions. Strangeness enhancement is observed which increases with centrality and with the strangeness co ntent of the hyperon.

  17. Transverse energy production in {sup 208}Pb+Pb collisions at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Alber, T.; Appelshaeuser, H.; Baechler, J.; Bartke, J.; Bialkowska, H.; Bieser, F.; Bloomer, M.A.; Blyth, C.O.; Bock, R.; Bormann, C.; Brady, F.P.; Brockmann, R.; Buncic, P.; Caines, H.L.; Cebra, D.; Chan, P.; Cooper, G.E.; Cramer, J.G.; Cramer, P.B.; Csato, P.; Derado, I.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Euler, S.; Ferguson, M.I.; Fischer, H.G.; Fodor, Z.; Foka, P.; Freund, P.; Fuchs, M.; Gal, J.; Gazdzicki, M.; Gladysz, E.; Grebieszkow, J.; Guenther, J.; Harris, J.W.; Heck, W.; Hegyi, S.; Hill, L.A.; Huang, I.; Howe, M.A.; Igo, G.; Irmscher, D.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kecskemeti, J.; Kowalski, M.; Kuehmichel, A.; Lasiuk, B.; Margetis, S.; Mitchell, J.W.; Mock, A.; Nelson, J.M.; Odyniec, G.; Palinkas, J.; Palla, G.; Panagiotou, A.D.; Petridis, A.; Piper, A.; Poskanzer, A.M.; Prindle, D.J.; Puehlhofer, F.; Rauch, W.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Roehrich, D.; Rudolph, H.; Runge, K.; Sandoval, A.; Sann, H.; Schaefer, E.; Schmitz, N.; Schoenfelder, S.; Seyboth, P.; Seyerlein, J.; Sikler, F.; Skrzypczak, E.; Stock, R.; Stroebele, H.; Szentpetery, I.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Vassiliou, M.; Vesztergombi, G.; Vranic, D.; Wenig, S.; Whitten, C.; Wienold, T.; Wood, L.; Zimanyi, J.; Zhu, X.; Zybert, R. [Department of Physics, University of Athens, Athens (Greece)]|[Lawrence Berkeley Laboratory, University of California, Berkeley California (United States)]|[Birmingham University, Birmingham (United Kingdom)]|[Institute of Physics, Budapest (Hungary)]|[CERN, Geneva (Switzerland)]|[Institute of Nuclear Physics, Cracow (Poland)]|[Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt (Germany)]|[University of California at Davis, Davis California (United States)]|[Fachbereich Physik der Universitaet, Frankfurt (Germany)]|[Fachbereich Physik der Universitaet, Freiburg (Germany)]|[University of California at Los Angeles, Los Angeles California (United States)

    1995-11-20

    Measurements of the forward and the transverse energy in 158 GeV per nucleon {sup 208}Pb+Pb collisions are presented. A total transverse energy of about 1 TeV is created in central collisions. An energy density of about 3GeV/fm{sup 3} is estimated for near head-on collisions. Only statistical fluctuations are seen in the ratio of electromagnetic to hadronic transverse energy. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

  18. COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making

    OpenAIRE

    Qinghua He; Gui Xue; Chuansheng Chen; Zhong-Lin Lu; Chunhui Chen; Xuemei Lei; Yuyun Liu; Jin Li; Bi Zhu; Moyzis, Robert K.; Qi Dong; Antoine Bechara

    2012-01-01

    Both genetic and environmental factors have been shown to influence decision making, but their relative contributions and interactions are not well understood. The present study aimed to reveal possible gene-environment interactions on decision making in a large healthy sample. Specifically, we examined how the frequently studied COMT Val158Met polymorphism interacted with an environmental risk factor (i.e., stressful life events) and a protective factor (i.e., parental warmth) to influence a...

  19. Determination of the number of wounded nucleons in Pb+Pb collisions at 158 A GeV/c

    CERN Document Server

    Antinori, Federico; Bakke, H; Barbera, R; Beker, H; Beusch, Werner; Bloodworth, Ian J; Botje, M; Caliandro, R; Campbell, M; Cantatore, E; Carena, W; Carrer, N; De Haas, A P; Di Bari, D; Di Liberto, S; Divià, R; Elia, D; Evans, D; Fanebust, K; Fedorisin, J; Feofilov, G A; Fini, R A; Ftácnik, J; Ghidini, B; Grella, G; Gulino, M; Helstrup, H; Holme, A K; Huss, D; Jacholkowski, A; Jones, G T; Jovanovic, P; Jusko, A; Kamermans, R; Kinson, J B; Klempt, W; Knudson, K; Kolojvari, A A; Králik, I; Kuijer, P; Lenti, V; Lietava, R; Loconsole, R A; Løvhøiden, G; Lupták, M; Manzari, V; Mazzoni, M A; Martinská, G; Meddi, F; Michalon, A; Michalon-Mentzer, M E; Morando, M; Nappi, E; Navach, F; Norman, P I; Palmeri, A; Pappalardo, G S; Pastircák, B; Pellegrini, F; Pisút, J; Pisútová, N; Posa, F; Quercigh, Emanuele; Riggi, F; Röhrich, D; Romano, G; Safarík, K; Sándor, L; Schillings, E; Segato, G F; Snoeys, W; Staroba, P; Stolyarov, O I; Thompson, M; Thorsteinsen, T F; Tomasicchio, G; Torrieri, G D; Tsimbal, F A; Tulina, T A; Turrisi, R; Tveter, T S; Urbán, J; Valiev, F F; Van den Brink, A; Van de Ven, P; Van de Vyvre, P; van Eijndhoven, N; Vannucci, Luigi; Vascotto, Alessandro; Villalobos Baillie, O; Vinogradov, I; Virgili, T; Votruba, M F; Vrláková, J; Závada, P

    1999-01-01

    The charged particle multiplicity distributions measured with the WA97 and the NA57 multiplicity detectors in Pb+Pb collisions at 158 A GeV/c have been analyzed in the framework of the Wounded Nucleon Model (WNM). We obtain a good description of the data within the centrality range of our samples. This allows us to make use of the measured multiplicities to estimate the number of wounded nucleons of the collision.

  20. Transverse mass distributions of neutral pions from 208Pb-induced reactions at 158 A GeV

    NARCIS (Netherlands)

    Aggarwal, M.M.; Agnihotri, A.; Ahammed, Z.A.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Barlag, C.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.-M.; Böröcz, Z.K.; Bucher, D.; Buijs, A.; Büsching, H.; Carlén, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbatchev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Delagrange, H.; Djordjadze, V.; Donni, P.; Doubovik, I.; Dubey, A.K.; Dutt, S.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Ganti, M.S.; Garpmann, S.; Gavrishchuk, O.; Geurts, F.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.-A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.-H.; Karadjev, K.; Karpio, K.; Kato, S.; Kees, S.; Klein-Bösing, C.; Knoche, S.; Kolb, B.; Kosarev, I.; Koutcheryaev, I.; Krümpel, T.; Kugler, A.; Kulinich, P.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Bevedev, A.; Lee, Y.Y.; Löhner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Mgebrichvili, G.; Miake, Y.; Mir, Md.F.; Mishra, G.C.; Mitamoto, Y.; Mohanti, B.; Mora, M.-J.; Morrison, D.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.

    Results on transverse mass spectra of neutral pious measured at central rapidity are presented for impact parameter selected 158-A GeV Pb + Pb-1 and Pb + Nb collisions. The distributions cover the range 0.5 GeV/c(2) less than or equal to MT - Mo less than or equal to 4 GeV/c(2). The change of the

  1. Upper Limit of D0 Production in Central Pb-Pb Collisions at 158A GeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Flierl, D; Fodor, Z; Foka, P; Friese, V; Gál, J; Gazdzicki, M; Genchev, V; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Nicolic, V; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Prindle, D; Pühlhofer, F; Renfordt, R; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Schuster, T; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Szymanski, P; Trubnikov, V; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zimányi, J

    2006-01-01

    Results are presented from a search for the decays D0 -> Kmin piplus and D0bar -> Kplus pimin in a sample of 3.8x10^6 central Pb-Pb events collected with a beam energy of 158A GeV by NA49 at the CERN SPS. No signal is observed. An upper limit on D0 production is derived and compared to predictions from several models.

  2. VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome

    Directory of Open Access Journals (Sweden)

    Laura Del Hoyo

    2016-10-01

    Full Text Available Down syndrome (DS is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC deficits. DS also present a high risk for early onset of Alzheimer Disease (AD-like dementia. The dopamine (DA system plays a neuromodulatory role in the activity of the PFC. Several studies have implicated trait differences in DA signaling on executive functioning based on genetic polymorphisms in the genes encoding for the catechol-O-methyltransferase (COMTVal158Met and the dopamine transporter (VNTR-DAT1. Since it is known that the phenotypic consequences of genetic variants are modulated by the genetic background in which they occur, we here explore whether these polymorphisms variants interact with the trisomic genetic background to influence gene expression, and how this in turn mediates DS phenotype variability regarding PFC cognition. We genotyped 69 young adults of both genders with DS, and found that VNTR-DAT1 was in Hardy-Weinberg equilibrium but COMTVal158Met had a reduced frequency of Met allele homozygotes. In our population, genotypes conferring higher DA availability, such as Met allele carriers and VNTR-DAT1 10-repeat allele homozygotes, resulted in improved performance in executive function tasks that require mental flexibility. Met allele carriers showed worse adaptive social skills and self-direction, and increased scores in the social subscale of the Dementia Questionnaire for People with Intellectual Disabilities than Val allele homozygotes. The VNTR-DAT1 was not involved in adaptive behavior or early dementia symptoms. Our results suggest that genetic variants of COMTVal158Met and VNTR-DAT1 may contribute to PFC-dependent cognition, while only COMTVal158Met is involved in behavioral phenotypes of DS, similar to euploid population.

  3. COMT Val158Met and PPARγ Pro12Ala polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.

    Science.gov (United States)

    Lee, Young Ho; Song, Gwan Gyu

    2014-05-01

    The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met or the peroxisome proliferator-activated receptor-gamma (PPARγ) Pro12Ala polymorphisms are associated with susceptibility to Alzheimer's disease (AD). We conducted a meta-analysis of the associations between the COMT Val158Met and the PPARγ Pro12Ala polymorphisms and AD in subjects. Meta-analysis showed no association between AD and the COMT G allele in any of the study subjects [odds ratio (OR) = 0.972, 95 % confidence intervals (95 % CI) = 0.893-1.059, p = 0.515]. Stratification by ethnicity indicated an association between the COMT GG+GA genotype and AD in an Asian group (OR = 0.702, 95 % CI = 0.517-0.953, p = 0.023), but not in Europeans (OR = 1.058, 95 % CI = 0.868-1.289, p = 0.579). Homozygote contrast analysis showed the same pattern for the COMT GG+GA genotype. Meta-analysis showed no association between AD and the PPARγ polymorphism (OR for the C allele = 0.963, 95 % CI = 0.818-1.134, p = 0.649). This meta-analysis identified an association between AD and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPARγ Pro12Ala polymorphism.

  4. Dielectron production in heavy ion collisions at 158 GeV/c per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Busch, Oliver

    2007-12-03

    In this thesis we study dilepton production in Pb-Au collisions at 158 GeV/c per nucleon measured with the Cherenkov Ring Electron Spectrometer (CERES) at the Super Proton Synchrotron (SPS) at CERN. The data taken in the year 2000 represent the first CERES runs with the fully operational Time Projection Chamber (TPC). The upgrade of the spectrometer with this powerful tracking device allows to realize a new approach for particle identification with the Ring Imaging Cherenkov (RICH) detector. We present the development and optimization of track-based ring reconstruction methods which allow to identify both electrons and pions at momenta above the Cherenkov threshold. To compare the performance of different methods, the reconstruction is applied to the CERES data. This allows to determine experimentally, for the first time, the CERES RICH efficiency and background rejection power. The new particle identification is used for low-mass dielectron reconstruction. Significant improvements in the simulation of the detector allow to evaluate the electron pair reconstruction efficiency with high accuracy and to study the origin of electron pair combinatorial background. The results motivate an extension of the TPC tracking, to improve the reconstruction efficiency for low-momentum tracks, and allow better identification of electron background. Our results corroborate the previous CERES findings of an enhancement of electron pairs over the hadronic cocktail in the invariant mass region m{sub inv} >or similar 0.2 GeV/c{sup 2}. Comparison to previous analyses of the same data shows good consistency and supports our estimate of the systematic uncertainties of the electron analysis. Our results supply evidence for a modification of the spectral function of the {rho} meson in the hot and dense medium and strongly support baryon-induced interactions at the origin of the effect. Furthermore, we present in this work the first direct measurements of transition radiation (TR) spectra

  5. Microstructure and dielectric properties of dysprosium-doped barium titanate ceramics Microestrutura e propriedades dielétricas de cerâmicas de titanato de bário dopado com disprósio

    Directory of Open Access Journals (Sweden)

    Y. Pu

    2005-09-01

    Full Text Available The substitution behavior and lattice parameter of barium titanate between solid_solubility with a dopant concentration in the range of 0.25 to 1.5 mol% are studied. The influences of dysprosium-doped fraction on the grain size and dielectric properties of barium titanate ceramic, including dielectric constant and breakdown electric field strength, are investigated via scanning electronic microscopy, X-ray diffraction and electric property tester. The results show that, at a dysprosium concentration of 0.75 mol%, the abnormal grain growth is inhibited and the lattice parameters of grain rise up to the maximum because of the lowest vacancy concentration. In addition, the finegrain and high density of barium titanate ceramic result in its excellent dielectric properties. The relative dielectric constant (25 °C reaches to 4100. The temperature coefficient of the capacitance varies from -10 to 10% within the temperature range of -15 °C -100 °C, and the breakdown electric field strength (alternating current achieves 3.2 kV/mm. These data suggest that our barium titanate could be used in the manufacture of high voltage ceramic capacitors.Foram estudados o comportamento da substituição e o parâmetro de rede de titanato de bário da solubilidade sólida com uma concentração de dopante na faixa 0,25-1,5 mol%. As influências da fração do dopante disprósio no tamanho de grão e nas propriedades dielétricas da cerâmica de titanato de bário, incluindo constante dielétrica e rigidez dielétrica foram investigadas por meio de microscopia eletrônica de varredura, difração de raios X e teste de propriedades elétricas. Os resultados mostram que a uma concentração de disprósio de 0,75 mol% o crescimento anormal de grão é inibido e os parâmetros de rede aumentam até um máximo devido a menor concentração de vacâncias. Além disso, as cerâmicas de grãos pequenos e alta densidade resultam em excelentes propriedades dielétricas. A

  6. Neodymium Dysprosium Modified Starch- coated Magnetic Fluid Preparation of Ferrite%淀粉包覆镝钕改性铁氧体磁性液体的制备

    Institute of Scientific and Technical Information of China (English)

    林穗云; 周育辉

    2011-01-01

    In this paper, in order to obtain the ferrite magnetic fluids of higher saturation magnetic intensity with simple technology, nanometer magnetite ( Fe3O4 ) particles ware prepared by chemical co - precipitation. And to a certain proportion of Dysprosium Neodymium ferrite magnetic fluids on the modification, we selected starch prepara- tion for the relief of water - based coating of rare earth iron oxide magnetic fluid composites. We also investigated the amount of Nd - Dy, the amount of coating agent, reaction temperature, coating temperature on the performance of the products and the effects of particle size, and its preliminary characterization was also performed . Through experiment,we summed up, under n (Fe) : [ n ( Nd3+ ) + n ( Dy3+ ) ] = 30:1 and n ( Fe3 + ) : n ( Fe2 + ) = 1.70 ~ 1. 75, the ratio for use of dysprosium and neodymium is n(Dy3+ ) : n(Nd3+ ) =4:1, 25%NH3 · H2O(A. R. ) as precipitating agent and pH value conditioner; the reacting system temperature was controlled in 35 ℃, and the pH value was adjusted to 9 ~ 11 ; the best dosage of starch as the relief is O. 0050g each 6OraL magnetic fluids, the temperature of surfactant was controlled in 50℃ and the pH value was adjusted to 2 ~ 3. In such system under the conditions of a water - based rare - earth compound Nd Dy Fe Magnetic, fluid magnetic oxygen was higher than or- dinary water- based ferrite.%为制备工艺简单且饱和磁化强度高的磁流体,本文采用化学共沉淀法制得了纳米磁性Fe304粒子.然后以一定比例的镝钕对铁氧体磁流体改性,选择淀粉为包覆剂制备水基稀土复合铁氧磁流体.考察了镝钕的用量、包覆剂的用量、反应温度、包覆温度等因素对产物粒径及性能的影响,并对其进行了初步的性能表征.实验总结出适宜的条件:在n(Fe):[n(Nd3+)+n(Dy3+)]=30:1,n(Fe3+):n(Fe2+)=1.70~1.75

  7. Protective Role of Maternal P.VAL158MET Catechol-O-methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications

    Directory of Open Access Journals (Sweden)

    Krnjeta Tijana

    2016-09-01

    Full Text Available Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT polymorphism and risk of preeclampsia (PE. The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA complicating PE.

  8. Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.

    Science.gov (United States)

    Klauke, Benedikt; Winter, Bernward; Gajewska, Agnes; Zwanzger, Peter; Reif, Andreas; Herrmann, Martin J; Dlugos, Andrea; Warrings, Bodo; Jacob, Christian; Mühlberger, Andreas; Arolt, Volker; Pauli, Paul; Deckert, Jürgen; Domschke, Katharina

    2012-01-01

    The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system--partly conferred by catechol-O-methyltransferase (COMT) gene variation--for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of the functional COMT Val158Met polymorphism, caffeine as an adenosine A2A receptor antagonist (300 mg in a placebo-controlled intervention design) and childhood maltreatment (CTQ) as well as their interaction on the affect-modulated startle response as a neurobiologically founded defensive reflex potentially related to fear- and distress-related disorders. COMT val/val genotype significantly increased startle magnitude in response to unpleasant stimuli, while met/met homozygotes showed a blunted startle response to aversive pictures. Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers. No main effect of or interaction effects with caffeine were observed. Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders.

  9. Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.

    Directory of Open Access Journals (Sweden)

    Namni Goel

    Full Text Available BACKGROUND: The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel marker in healthy adults of differential vulnerability to chronic partial sleep deprivation (PSD, a condition distinct from total sleep loss and one experienced by millions on a daily and persistent basis. METHODOLOGY/PRINCIPAL FINDINGS: 20 Met/Met, 64 Val/Met, and 45 Val/Val subjects participated in a protocol of two baseline 10h time in bed (TIB nights followed by five consecutive 4 h TIB nights. Met/Met subjects showed differentially steeper declines in non-REM EEG slow-wave energy (SWE-the putative homeostatic marker of sleep drive-during PSD, despite comparable baseline SWE declines. Val/Val subjects showed differentially smaller increases in slow-wave sleep and smaller reductions in stage 2 sleep during PSD, and had more stage 1 sleep across nights and a shorter baseline REM sleep latency. The genotypes, however, did not differ in performance across various executive function and cognitive tasks and showed comparable increases in subjective and physiological sleepiness in response to chronic sleep loss. Met/Met genotypic and Met allelic frequencies were higher in whites than African Americans. CONCLUSIONS/SIGNIFICANCE: The COMT Val158Met polymorphism may be a genetic biomarker for predicting individual differences in sleep physiology-but not in cognitive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult population of men and women. Beyond healthy sleepers, our results may also provide insight for predicting sleep loss responses in patients with schizophrenia and other psychiatric disorders, since these groups repeatedly experience chronically-curtailed sleep and demonstrate COMT

  10. The influence of the Val158Met catechol-O-methyltransferase polymorphism on the personality traits of bipolar patients.

    Directory of Open Access Journals (Sweden)

    Wendy Dávila

    Full Text Available INTRODUCTION: Certain personality traits and genetic polymorphisms are contributing factors to bipolar disorder and its symptomatology, and in turn, this syndrome influences personality. The aim of the present study is to compare the personality traits of euthymic bipolar patients with healthy controls and to investigate the effect of the catechol-O-methyltransferase (COMT Val158Met genotype on those traits. We recruited thirty seven bipolar I patients in euthymic state following a manic episode and thirty healthy controls and evaluated their personality by means of the Cloninger's Temperament and Character Inventory (version TCI-R-140. We assessed the influence of the polymorphism Val158Met in the COMT gene on the personality of these patients. The patients scored higher than controls in harm avoidance (61.3±12.5 vs. 55.3±8.1 and self-transcendence (45.3±12.8 vs. 32.7±8.2 and scored lower than controls in self-directedness (68.8±13.3 vs. 79.3±8.1, cooperativeness (77.1±9.1 vs. 83.9±6.5 and persistence (60.4±15.1 vs. 67.1±8.9. The novelty seeking dimension associates with the Val158Met COMT genotype; patients with the low catabolic activity genotype, Met/Met, show a higher score than those with the high catabolic activity genotype, Val/Val. CONCLUSIONS: Suffering from bipolar disorder could have an impact on personality. A greater value in harm avoidance may be a genetic marker for a vulnerability to the development of a psychiatric disorder, but not bipolar disorder particularly, while a low value in persistence may characterize affective disorders or a subgroup of bipolar patients. The association between novelty seeking scores and COMT genotype may be linked with the role dopamine plays in the brain's reward circuits.

  11. Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.

    Directory of Open Access Journals (Sweden)

    Benedikt Klauke

    Full Text Available The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system--partly conferred by catechol-O-methyltransferase (COMT gene variation--for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of the functional COMT Val158Met polymorphism, caffeine as an adenosine A2A receptor antagonist (300 mg in a placebo-controlled intervention design and childhood maltreatment (CTQ as well as their interaction on the affect-modulated startle response as a neurobiologically founded defensive reflex potentially related to fear- and distress-related disorders. COMT val/val genotype significantly increased startle magnitude in response to unpleasant stimuli, while met/met homozygotes showed a blunted startle response to aversive pictures. Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers. No main effect of or interaction effects with caffeine were observed. Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders.

  12. On Antiproton Production in 158 GeV/c Proton-Carbon Collisions and Nuclear Temperature of Interacting System

    Directory of Open Access Journals (Sweden)

    Fu-Hu Liu

    2013-01-01

    Full Text Available The multisource thermal model is used in this paper to analyze the antiproton (p¯ production process in high-energy proton-carbon (p-C collisions. The transverse momentum, Feynman variable, and rapidity distributions of antiprotons in the nucleon-nucleon center-of-mass system are calculated by using the model. The modeling results are compared and found to be in agreement with the experimental data measured by the NA49 Collaboration at 158 GeV/c beam momentum. As a parameter, the nuclear temperature of interacting system extracted from the antiproton spectrum is estimated to be about 150 MeV.

  13. Recent results on anomalous J/psi suppression in Pb-Pb collisions at 158 AGeV/c

    CERN Document Server

    Santos, H; Alexa, C; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Bedjidian, Marc; Beolè, S; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prado da Silva, W L; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N; Wu, T

    2002-01-01

    We report our latest results on charmonium suppression as measured at the CERN-SPS in Pb-Pb interactions at an incident beam momentum of 158 GeV/c per nucleon. Preliminary results obtained from the most recent sample of data collected in year 2000 under improved experimental conditions are compared with published results. For the most peripheral Pb-Pb collisions, J/psi suppression agrees with the normal absorption measured from interactions of lighter nuclei while a steady increasing abnormal supression is observed with increasing centrality.

  14. Production of Λ-hyperons in inelastic p+p interactions at 158 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Aduszkiewicz, A.; Dominik, W.; Kuich, M.; Matulewicz, T.; Posiadala, M. [University of Warsaw, Warsaw (Poland); Ali, Y. [Jagiellonian University, Cracow (Poland); COMSATS Institute of Information Technology, Department of Physics, Islamabad (Pakistan); Andronov, E.; Feofilov, G.A.; Igolkin, S.; Kondratiev, V.P.; Seryakov, A.; Vechernin, V.V.; Vinogradov, L. [St. Petersburg State University, St. Petersburg (Russian Federation); Anticic, T.; Kadija, K. [Ruder Boskovic Institute, Zagreb (Croatia); Antoniou, N.; Christakoglou, P.; Davis, N.; Diakonos, F.; Kapoyannis, A.; Panagiotou, A.D.; Vassiliou, M. [University of Athens, Athens (Greece); Baatar, B.; Bunyatov, S.A.; Kolesnikov, V.I.; Krasnoperov, A.; Lyubushkin, V.V.; Malakhov, A.I.; Matveev, V.; Melkumov, G.L.; Tereshchenko, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bay, F.; Di Luise, S.; Rubbia, A.; Sgalaberna, D. [ETH Zuerich, Zuerich (Switzerland); Blondel, A.; Bravar, A.; Damyanova, A.; Haesler, A.; Korzenev, A.; Ravonel, M. [University of Geneva, Geneva (Switzerland); Bogomilov, M.; Kolev, D.; Tsenov, R. [University of Sofia, Faculty of Physics, Sofia (Bulgaria); Brandin, A.; Selyuzhenkov, I.; Taranenko, A. [National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Moscow (Russian Federation); Brzychczyk, J.; Larsen, D.; Planeta, R.; Richter-Was, E.; Staszel, P.; Wyszynski, O. [Jagiellonian University, Cracow (Poland); Busygina, O.; Golubeva, M.; Guber, F.; Ivashkin, A.; Kurepin, A.; Sadovsky, A. [Institute for Nuclear Research, Moscow (Russian Federation); Cirkovic, M.; Manic, D.; Puzovic, J. [University of Belgrade, Belgrade (Serbia); Czopowicz, T.; Dynowski, K.; Grebieszkow, K.; Mackowiak-Pawlowska, M.; Maksiak, B.; Slodkowski, M.; Tefelski, D. [Warsaw University of Technology, Warsaw (Poland); Dembinski, H.; Engel, R.; Herve, A.E.; Mathes, H.J.; Roth, M.; Szuba, M.; Ulrich, R.; Unger, M.; Veberic, D. [Karlsruhe Institute of Technology, Karlsruhe (Germany); Deveaux, M.; Koziel, M.; Renfordt, R.; Stroebele, H. [University of Frankfurt, Frankfurt (Germany); Dumarchez, J.; Robert, A. [University of Paris VI and VII, LPNHE, Paris (France); Ereditato, A.; Hierholzer, M.; Nirkko, M.; Pistillo, C.; Redij, A. [University of Bern, Bern (Switzerland); Fodor, Z. [Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest (Hungary); University of Wroclaw, Wroclaw (Poland); Garibov, A. [National Nuclear Research Center, Baku (Azerbaijan); Gazdzicki, M. [University of Frankfurt, Frankfurt (Germany); Jan Kochanowski University in Kielce, Kielce (Poland); Grzeszczuk, A.; Kaptur, E.; Kisiel, J.; Kowalski, S.; Pulawski, S.; Schmidt, K.; Wilczek, A. [University of Silesia, Katowice (Poland); Hasegawa, T.; Kobayashi, T.; Nakadaira, T.; Nishikawa, K.; Sakashita, K.; Sekiguchi, T.; Shibata, M.; Tada, M. [Institute for Particle and Nuclear Studies, Tsukuba (Japan); Johnson, S.R.; Marino, A.D.; Nagai, Y.; Rumberger, B.T.; Zimmerman, E.D. [University of Colorado, Boulder (United States); Kowalik, K.; Rondio, E.; Stepaniak, J. [National Centre for Nuclear Research, Warsaw (Poland); Laszlo, A.; Marton, K.; Vesztergombi, G. [Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest (Hungary); Lewicki, M.; Naskret, M.; Turko, L. [University of Wroclaw, Wroclaw (Poland); Marcinek, A. [Jagiellonian University, Cracow (Poland); University of Wroclaw, Wroclaw (Poland); Messerly, B.; Paolone, V. [University of Pittsburgh, Pittsburgh (United States); Mills, G.B. [Los Alamos National Laboratory, Los Alamos (United States); Morozov, S.; Petukhov, O. [Institute for Nuclear Research, Moscow (Russian Federation); National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Moscow (Russian Federation); Mrowczynski, S.; Rybczynski, M.; Seyboth, P.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University in Kielce, Kielce (Poland); Pavin, M. [Ruder Boskovic Institute, Zagreb (Croatia); University of Paris VI and VII, LPNHE, Paris (France); Popov, B.A. [University of Paris VI and VII, LPNHE, Paris (France); Joint Institute for Nuclear Research, Dubna (Russian Federation); Rauch, W. [Fachhochschule Frankfurt, Frankfurt (Germany); Roehrich, D. [University of Bergen, Bergen (Norway); Rustamov, A. [National Nuclear Research Center, Baku (Azerbaijan); University of Frankfurt, Frankfurt (Germany); Susa, T. [Ruder Boskovic Institute, Zagreb (Croatia); Zambelli, L. [University of Paris VI and VII, LPNHE, Paris (France); Institute for Particle and Nuclear Studies, Tsukuba (Japan); Collaboration: NA61/SHINE Collaboration

    2016-04-15

    Inclusive production of Λ-hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158 GeV/c. Spectra of transverse momentum and transverse mass as well as distributions of rapidity and x{sub F} are presented. The mean multiplicity was estimated to be 0.120 ± 0.006(stat.) ± 0.010(sys.). The results are compared with previous measurements and predictions of the Epos, Urqmd and Fritiof models. (orig.)

  15. Electric charge fluctuations in central Pb+Pb collisions at 20, 30, 40, 80 and 158 AGeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    Results are presented on event-by-event electric charge fluctuations in central Pb+Pb collisions at 20, 30, 40, 80 and 158 AGeV. The observed fluctuations are close to those expected for a gas of pions correlated by global charge conservation only. These fluctuations are considerably larger than those calculated for an ideal gas of deconfined quarks and gluons. The present measurements do not necessarily exclude reduced fluctuations from a quark-gluon plasma because these might be masked by contributions from resonance decays.

  16. Inclusive production of charged pions in p+C collisions at 158 GeV/c beam momentum

    CERN Document Server

    Alt, C; Barna, D; Barr, G; Bartke, Jerzy; Betev, L; Biakowska, H; Blume, C; Boimska, B; Bracinik, J; Bramm, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Dinkelaker, P; Dolejsi, J; Eckardt, V; Fischer, H G; Flierl, D; Fodor, Z; Foka, P; Friese, V; Gazdzicki, M; Georgopoulos, G; Höhne, C; Karev, A; Kniege, S; Kollegger, T; Kolesnikov, V I; Kornas, E; Kowalski, M; Kraus, I; Kreps, M; Litov, L; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mitrovski, M; Pálla, G; Panagiotou, A D; Panayotov, D; Pattison, C; Petridis, A; Renfordt, R; Rybicki, A; Sandoval, A; Schmitz, N; Seyboth, P; Siklér, F; Stock, R; Ströbele, H; Sziklai, J; Szymanski, P; Trubnikov, V; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wenig, S; Wetzler, A; Zaranek, J

    2007-01-01

    The production of charged pions in minimum bias p+C interactions is studied using a sample of 377000 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The data cover a phase space area ranging from 0 to 1.8 GeV/c in transverse momentum and from -0.1 to 0.5 in Feynman x. Inclusive invariant cross sections are given on a grid of 270 bins per charge thus offering for the first time a dense coverage of the projectile hemisphere and of the cross-over region into the target fragmentation zone.

  17. Centrality dependence of K+ produced in Pb+Pb collisions at 158 GeV per nucleon

    CERN Document Server

    Arsenescu, R; Baglin, C; Beck, H P; Borer, K; Bussière, A; Elsener, K; Gorodetzky, P; Guillaud, J P; Hess, P; Kabana, S; Klingenberg, R; Lehmann, G; Lindén, T; Lohmann, K D; Mommsen, R K; Moser, U; Pretzl, Klaus P; Schacher, J; Stoffel, F; Spiwoks, R; Tuominiemi, Jorma; Weber, M; Gorodetzky, Ph.

    2001-01-01

    The NA52 collaboration searches for a discontinuous behaviour of charged kaons produced in Pb+Pb collisions at 158 A GeV as a function of the impact parameter, which could reveal a hadron to quark-gluon plasma (QGP) phase transition. The K+ yield is found to grow proportional to the number of participating ('wounded') nucleons N, above N=100. Previous NA52 data agree with the above finding and show a discontinuous behaviour in the kaon centrality dependence near N=100, marking the onset of strangeness enhancement -over e.g. p+A data at the same \\sqrt{s}- in a chemically equilibrated phase.

  18. An investigation of the antinuclei and nuclei production mechanism in Pb + Pb collisions at 158-A-GeV

    Energy Technology Data Exchange (ETDEWEB)

    Arsenescu, R [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Baglin, C [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Beck, H P [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Borer, K [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Bussiere, A [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Elsener, K [CERN, SL Division, CH-1211 Geneva 23 (Switzerland); Gorodetzky, Ph [PCC - College de France, 11 Place Marcellin Berthelod, 75005 Paris, France (France); Guillaud, J P [CNRS-IN2P3, LAPP Annecy, F-74941 Annecy-le-Vieux (France); Kabana, S [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Klingenberg, R [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Lehmann, G [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Linden, T [Helsinki Institute of Physics, PO Box 9, FIN-00014 Helsinki (Finland); Lohmann, K D [CERN, SL Division, CH-1211 Geneva 23 (Switzerland); Mommsen, R [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Moser, U [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Pretzl, K [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Schacher, J [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Spiwoks, R [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland); Tuominiemi, J [Helsinki Institute of Physics, PO Box 9, FIN-00014 Helsinki (Finland); Weber, M [Laboratorium fuer Hochenergiephysik, Universitaet Bern, Sidlerstrasse 5, 3012-Bern (Switzerland)

    2003-11-01

    We investigate the production mechanisms of p, d, t, {sup 3}He, {sup 4}He, {sup 6}Li, pbar,dbar and {sup 3}Hebar in Pb+Pb collisions at 158-A-GeV measured near zero transverse momentum with the NA52 experiment at the CERN SPS. We find evidence that nuclei and antinuclei in Pb+Pb collisions are mainly produced via the coalescence mechanism out of a thermalized source of hadrons, at a time close to the thermal freeze-out of hadrons corresponding to a temperature of {approx}120-MeV.

  19. New results from NA52 on particle production in Pb-Pb collisions at 158 A GeV/c

    Science.gov (United States)

    Arsenescu, R.; NA52 Collaboration; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Bohm, C.; Borer, K.; Bussière, A.; Dittus, F.; Elsener, K.; Gorodetsky, Ph.; Guillaud, J. P.; Hess, P.; Kabana, S.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Selldén, B.; Stoffel, F.; Tuominiemi, J.; Weber, M.; Zhang, Q. P.

    1999-02-01

    We are presenting new results on and production in minimum bias lead-lead collisions at 158 A GeV/c. The measurements were performed at zero degree production angle and for a wide rapidity range. The analysis method used the full particle identification capabilities (time of flight, Cerenkov counters and hadronic calorimeter) of the spectrometer. We show K/ and ratios as a function of rapidity, as well as invariant particle production cross sections. As a particularity we observe near projectile rapidity an enhancement in the number of with respect to .

  20. An investigation of the antinuclei and nuclei production mechanism in Pb + Pb collisions at 158 A GeV

    Science.gov (United States)

    Arsenescu, R.; Baglin, C.; Beck, H. P.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Kabana, S.; Klingenberg, R.; Lehmann, G.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Spiwoks, R.; Tuominiemi, J.; Weber, M.

    2003-11-01

    We investigate the production mechanisms of p, d, t, 3He, 4He, 6Li, \\overline {\\mathrm {p}} , \\overline {\\mathrm {d}} and \\overline {^3{\\mathrm {He}}} in Pb+Pb collisions at 158 A GeV measured near zero transverse momentum with the NA52 experiment at the CERN SPS. We find evidence that nuclei and antinuclei in Pb+Pb collisions are mainly produced via the coalescence mechanism out of a thermalized source of hadrons, at a time close to the thermal freeze-out of hadrons corresponding to a temperature of ~120 MeV.

  1. Centrality dependence of K+ produced in Pb+Pb collisions at 158 GeV per nucleon

    CERN Document Server

    Arsenescu, R; Borer, K; Kabana, S; Klingenberg, R; Lehmann, G; Mommsen, R K; Moser, U; Pretzl, Klaus P; Schacher, J; Spiwoks, R; Weber, M; Elsener, K; Lohmann, K D; Baglin, C; Bussière, A; Guillaud, J P; Lindén, T; Tuominiemi, Jorma; Gorodetzky, P; Gorodetzky, Ph.

    2000-01-01

    The NA52 collaboration searches for a discontinuous behaviour of charged kaons produced in Pb+Pb collisions at 158 A GeV as a function of the impact parameter, which could reveal a hadron to quark-gluon plasma (QGP) phase transition. The K+ yield is found to grow proportional to the number of participating ('wounded') nucleons N, above N=100. Previous NA52 data agree with the above finding and show a discontinuous behaviour in the kaon centrality dependence near N=100, marking the onset of strangeness enhancement -over e.g. p+A data at the same \\sqrt{s}- in a chemically equilibrated phase.

  2. The NA52 strangelet and particle search in Pb+Pb collisions at 158 A GeV/c

    Science.gov (United States)

    Weber, M.; NA52 Collaboration; Arsenescu, R.; Baglin, C.; Beck, H. P.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Kabana, S.; Klingenberg, R.; Lehmann, G.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Spiwoks, R.; Tuominiemi, J.; Weber, M.

    2002-07-01

    The NA52 experiment searched for long-lived charged strangelets in 158 A GeV/c Pb+Pb collisions at CERN SPS. We collected 1013 Pb+Pb interactions looking for negatively charged strangelets and 3 × 1011 Pb+Pb interactions for positively charged ones. No evidence for the production of strangelets has been observed. The upper strangelet production limits are discussed. Besides the strangelet searches NA52 was able to identify particles and anti-particles over a wide range in rapidity. Results of the invariant differential particle production cross sections including fragments up to carbon and 5 0954-3899/28/7/347/hebar_1 are presented.

  3. 158 AGeV/c Pb-Pb碰撞中的J/Ψ反常抑制现象研究%Investigations of J/Ψ Anomalous Suppressions in Pb-Pb Collisions at 158 AGeV/c

    Institute of Scientific and Technical Information of China (English)

    姜志进

    2011-01-01

    在核吸收与随动者吸收理论的基础上,给出了在有QGP相变情况下高能重离子碰撞中的J/Ψ微分产生截面,并用其讨论了CERN的NA50合作组给出的入射动量为158 AGeV/c的Pb-Pb碰撞中的J/Ψ反常抑制现象。理论较好地解释了实验结果。%On the basis of nuclear and comover absorption theories,we have derived out the differential cross section of J/Ψ production in high-energy heavy-ion collisions under the situation that QGP phase transition occurs,and analyzed the experimental data of NA50 Collaboration at CERN in Pb-Pb collisions at 158 AGeV/c.Our theory favors the data well.

  4. 子宫内膜病变158例的诊断与治疗分析

    Institute of Scientific and Technical Information of China (English)

    杨柳枝

    2013-01-01

    目的:子宫内膜病变诊断与治疗以及妇女病筛查的重要性。方法对158例有症状绝经妇女进行超声检查,并行诊断性刮宫,内膜送病理检查。结果分析其中的阳性符合率,以期超声作为绝经妇女内膜癌的主要筛查手段。结论超声是经济、实用、无痛、无创、快捷的子宫内膜病变筛查的可靠检查方法,对临床诊疗有重要的指导意义。%Objective: To explore the diagnosis and treatment of endometrial lesions as wel as the importance of screening women disease; methods: 158patients with symptomatic postmenopausal women by ultrasonography, paral el diagnostic curettage, endometrial sent for histopathological examination, analysis the positive coincidence rate, with period ultrasound as premenopausal women with endometrial carcinoma primary screening tools, conclusion: Ultrasound is the economy, practical, painless, non-invasive, fast endometrial disease screening and reliable inspection method for clinical diagnosis and treatment, has the important guiding significance.

  5. Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory.

    Directory of Open Access Journals (Sweden)

    Esther M Opmeer

    Full Text Available Major depressive disorder (MDD has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT gene has been shown to influence prefrontal cortex (PFC activation during both emotional processing and working memory (WM. Although COMT-genotype is not directly associated with MDD, it may affect MDD pathology by altering PFC activation, an endophenotype associated with both COMT and MDD. 125 participants, including healthy controls (HC, n=28 and MDD patients were genotyped for the COMT val158met polymorphism and underwent functional magnetic resonance imaging (fMRI-neuroimaging during emotion processing (viewing of emotional facial expressions and a WM task (visuospatial planning. Within HC, we observed a positive correlation between the number of met-alleles and right inferior frontal gyrus activation during emotional processing, whereas within patients the number of met-alleles was not correlated with PFC activation. During WM a negative correlation between the number of met-alleles and middle frontal gyrus activation was present in the total sample. In addition, during emotional processing there was an effect of genotype in a cluster including the amygdala and hippocampus. These results demonstrate that COMT genotype is associated with relevant endophenotypes for MDD. In addition, presence of MDD only interacts with genotype during emotional processing and not working memory.

  6. Catechol-O-Methyltransferase (COMT Val108/158 Met polymorphism does not modulate executive function in children with ADHD

    Directory of Open Access Journals (Sweden)

    Stepanian Marina

    2004-12-01

    Full Text Available Abstract Background An association has been observed between the catechol-O-methyltransferase (COMT gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC, and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD are mediated by prefrontal dopamine (DA mechanisms, we investigated the relationship between a functional polymorphism of the COMT gene and neuropsychological task performance in these children. Methods The Val108/158 Met polymorphism of the COMT gene was genotyped in 118 children with ADHD (DSM-IV. The Wisconsin Card Sorting Test (WCST, Tower of London (TOL, and Self-Ordered Pointing Task (SOPT were employed to evaluate executive functions. Neuropsychological task performance was compared across genotype groups using analysis of variance. Results ADHD children with the Val/Val, Val/Met and Met/Met genotypes were similar with regard to demographic and clinical characteristics. No genotype effects were observed for WCST standardized perseverative error scores [F2,97 = 0.67; p > 0.05], TOL standardized scores [F2,99 = 0.97; p > 0.05], and SOPT error scores [F2,108 = 0.62; p > 0.05]. Conclusions Contrary to the observed association between WCST performance and the Val108/158 Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.

  7. Study of projectile fragmentation in the reaction (158 A GeV) Pb + Pb using CR-39

    CERN Document Server

    Qureshi, I E; Javed, M T; Manzoor, S; Sher, G; Aleem, F; Khan, H A

    2005-01-01

    The fragmentation of Pb ions at 158 A GeV energy produced in the interaction with Pb target has been studied using a CR-39 track detector. A stack comprising of 64 detectors was prepared such that a target of 1 cm thickness was sandwiched between the sheets of CR-39. The purpose of this exposure geometry was to calibrate CR-39 with respect to relativistic heavy ions as well as to study the fragmentation of Pb ions at 158 A GeV energy. The exposure was carried out at the SPS beam facility of CERN at normal incidence with a fluence of . Two detectors from the exposed stack have been selected for this study: one before and the other after the target material. After etching, the detectors were scanned using an optical microscope and the etched track lengths and the diameters of the track openings were measured manually. Considering that the lengths of tracks provide the best charge resolution for Z>65, we have measured track lengths for a sufficiently large number of fragments to identify individual charge states...

  8. Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.

    Science.gov (United States)

    Orlandi, Cesare; Xie, Keqiang; Masuho, Ikuo; Fajardo-Serrano, Ana; Lujan, Rafael; Martemyanov, Kirill A

    2015-05-29

    Regulators of G protein signaling control the duration and extent of signaling via G protein-coupled receptor (GPCR) pathways by accelerating the GTP hydrolysis on G protein α subunits thereby promoting termination of GPCR signaling. A member of this family, RGS7, plays a critical role in the nervous system where it regulates multiple neurotransmitter GPCRs that mediate vision, memory, and the action of addictive drugs. Previous studies have established that in vivo RGS7 forms mutually exclusive complexes with the membrane protein RGS7-binding protein or the orphan receptor GPR158. In this study, we examine the impact of GPR158 on RGS7 in the brain. We report that knock-out of GPR158 in mice results in marked post-transcriptional destabilization of RGS7 and substantial loss of its association with membranes in several brain regions. We further identified the RGS7-binding site in the C terminus of GPR158 and found that it shares significant homology with the RGS7-binding protein. The proximal portion of the GPR158 C terminus additionally contained a conserved sequence that was capable of enhancing RGS7 GTPase-activating protein activity in solution by an allosteric mechanism acting in conjunction with the regulators of the G protein signaling-binding domain. The distal portion of the GPR158 C terminus contained several phosphodiesterase E γ-like motifs and selectively recruited G proteins in their activated state. The results of this study establish GPR158 as an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. 表面修饰对镝铁氧体纳米磁粒子的合成及其磁性能的影响%Effect of Surface Modification on Formation and Magnetic Property of Dysprosium Ferrite Nanomagnetic Particles

    Institute of Scientific and Technical Information of China (English)

    陈静; 张茂润; 邓真娟

    2011-01-01

    利用湿化学法制备镝铁氧体纳米磁粒子时,用适量的阴离子表面活性剂进行表面修饰,能够有效地控制磁粒子的粒径,同时避免干燥时产生硬团聚.文章介绍了用月桂酸、月桂酸钠、正十二烷基硫酸钠对磁粒子进行表面修饰的研究结果,探讨了三者及其用量对磁粒子的形成及磁性能的影响.借助X射线衍射仪(XRD)、透射电镜(TEM)、振动样品磁强计(VSM)、红外光谱仪(IR)对产物的性能进行了表征.结果表明,用月桂酸修饰后的产物具有Fe3O4磁粒子的晶型结构且结晶度高、磁性能优异、平均粒径约16nm;用月桂酸钠、正十二烷基硫酸钠修饰后的产物不具有Fe3O4磁粒子的晶型结构,结晶度低且磁性能差.%When wet chemical method are use to prepare dysprosium-doped ferrite magnetic nanoparticles, right a-mount of anionic surfactant were doped as surface modification, which can effectively control the size of magnetic particles, and avoid producing hard reunion when dry out. This paper introduces the research results of magnetic particle surface modification by using lauric acid, laurel acid sodium and lauryl sodium sulfate, discusses the effect of lauric acid, laurel acid sodium and lauryl sodium sulfate and their dosages on the formation of magnetic and its magnetic property. The properties of the product can be characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), infrared spectrometer (IR). The results showed that the product modified with lauric acid have a crystalline structure of Fe3O4 magnetic particles and high crystallin-ity, excellent magnetic properties. The average particle size is about 16 nm; the product modified with laurel acid sodium and lauryl sodium sulfate does not have the crystalline structure of Fe3O4 magnetic particles, with low crystal-linity and low magnetic property.

  10. 158A GeV/c Pb-Pb碰撞中的QGP相变问题研究%Study on QGP phase transition in Pb-Pb collisions at 158A GeV/c

    Institute of Scientific and Technical Information of China (English)

    李强; 姜志进; 夏宏福

    2006-01-01

    以J/ψ反常抑制现象为夸克-胶子等离子体(QGP)相变信号,在核与随动者吸收理论的基础上,导出了有相变产生时高能重离子碰撞中的J/ψ微分产生截面,并对NA50合作组给出的入射动量为158A GeV/c的Pb-Pb碰撞中的实验数据进行了分析,较好地解释了实验结果.表明在NA50合作组的实验中,QGP物质已经产生.

  11. The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study

    Directory of Open Access Journals (Sweden)

    Skorpen Frank

    2007-06-01

    Full Text Available Abstract Background The catechol-O-methyltransferase (COMT gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. Whether the Val158Met polymorphism is associated with survival has not been evaluated in the general population. The aim of this prospective study was to evaluate the impact of codon 158 COMT gene polymorphism on survival in a population-based cohort. Methods The sample comprised 2979 non-diabetic individuals who participated in the Nord-Trøndelag Health Study (HUNT in the period 1995–97. The subjects were followed up with respect to mortality throughout year 2004. Results 212 men and 183 women died during the follow up. No association between codon 158 COMT gene polymorphism and survival was found. The unadjusted relative risk of death by non-ischemic heart diseases with Met/Met or Met/Val genotypes was 3.27 (95% confidence interval, 1.19–9.00 compared to Val/Val genotype. When we adjusted for age, gender, smoking, coffee intake and body mass index the relative risk decreased to 2.89 (95% confidence interval, 1.04–8.00. Conclusion During 10 year of follow-up, the Val158Met polymorphism had no impact on survival in a general population. Difference in mortality rates from non-ischemic heart diseases may be incidental and should be evaluated in other studies.

  12. Association of catechol-O-methyltransferase Val(108/158) Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population.

    Science.gov (United States)

    Mao, Qiao; Tan, Yun-Long; Luo, Xing-Guang; Tian, Li; Wang, Zhi-Ren; Tan, Shu-Ping; Chen, Song; Yang, Gui-Gang; An, Hui-Mei; Yang, Fu-De; Zhang, Xiang-Yang

    2016-08-30

    Catechol-O-methyltransferase (COMT), an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, is associated with the sensory gating phenomenon, protecting the cerebral cortex from information overload. The COMT Val(108/158)Met polymorphism is essential for prefrontal cortex processing capacity and efficiency. The current study was designed to investigate the role of COMT Val(108/158)Met polymorphism in development, sensory gating deficit, and symptoms of schizophrenia in Han Chinese population. P50 gating was determined in 139 schizophrenic patients and 165 healthy controls. Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptomatology in 370 schizophrenic subjects. COMT Val(108/158)Met polymorphism was genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP). No significant differences in COMT allele and genotype distributions were observed between schizophrenic patients and control groups. Although P50 deficits were present in patients, there was no evidence for an association between COMT Val(108/158)Met polymorphism and the P50 biomarker. Moreover, PANSS negative subscore was significantly higher in Val allele carriers than in Met/Met individuals. The present findings suggest that COMT Val(108/158)Met polymorphism may not contribute to the risk of schizophrenia and to the P50 deficits, but may contribute to the negative symptoms of schizophrenia among Han Chinese.

  13. The Influence of the Val158Met Catechol-O-Methyltransferase Polymorphism on the Personality Traits of Bipolar Patients

    Science.gov (United States)

    Dávila, Wendy; Basterreche, Nieves; Arrue, Aurora; Zamalloa, María I.; Gordo, Estíbaliz; Dávila, Ricardo; González-Torres, Miguel A.; Zumárraga, Mercedes

    2013-01-01

    Introduction Certain personality traits and genetic polymorphisms are contributing factors to bipolar disorder and its symptomatology, and in turn, this syndrome influences personality. The aim of the present study is to compare the personality traits of euthymic bipolar patients with healthy controls and to investigate the effect of the catechol-O-methyltransferase (COMT) Val158Met genotype on those traits. We recruited thirty seven bipolar I patients in euthymic state following a manic episode and thirty healthy controls and evaluated their personality by means of the Cloninger’s Temperament and Character Inventory (version TCI-R-140). We assessed the influence of the polymorphism Val158Met in the COMT gene on the personality of these patients. The patients scored higher than controls in harm avoidance (61.3±12.5 vs. 55.3±8.1) and self-transcendence (45.3±12.8 vs. 32.7±8.2) and scored lower than controls in self-directedness (68.8±13.3 vs. 79.3±8.1), cooperativeness (77.1±9.1 vs. 83.9±6.5) and persistence (60.4±15.1 vs. 67.1±8.9). The novelty seeking dimension associates with the Val158Met COMT genotype; patients with the low catabolic activity genotype, Met/Met, show a higher score than those with the high catabolic activity genotype, Val/Val. Conclusions Suffering from bipolar disorder could have an impact on personality. A greater value in harm avoidance may be a genetic marker for a vulnerability to the development of a psychiatric disorder, but not bipolar disorder particularly, while a low value in persistence may characterize affective disorders or a subgroup of bipolar patients. The association between novelty seeking scores and COMT genotype may be linked with the role dopamine plays in the brain’s reward circuits. PMID:23646156

  14. [Analysis of clinical characteristic of 158 inpatients with dengue fever in Guangzhou area during the 2014 epidemic].

    Science.gov (United States)

    Ye, Zi; Huang, Yingxiong; Jiang, Peng; Zheng, Ziyu; Xiong, Yan; Xu, Jia; Xiao, Xiaoyong; Zhan, Hong

    2015-04-01

    To investigate the clinical characteristics of the inpatients suffering from dengue fever in order to provide references for better diagnosis and treatment. The clinical data of 158 dengue fever patients admitted to the First Affiliated Hospital of Sun Yat-Sen University from July 23rd to October 31st, 2014 during the 2014 epidemic in Guangzhou area were retrospectively analyzed, including general clinical manifestations, conventional examinations, pathogenesis, and prognosis. The mean age of the 158 patients was ( 56 ± 20 ) years, with half of them over 60 years old (79 cases). Among them, 94 (59.49%) were male. (1) The common manifestations included fever (100%), headache (70.89%), myalgia/bone soreness (62.03%), and skin rash (54.43%). Bleeding and plasma leakage were found in 25.95% and 14.56% of the patients respectively. (2) Laboratory examination: leucopenia (75.32%) and thrombocytopenia (77.85%) were found, and alanine aminotransferase (ALT) and aspartate aminotransferase ( AST ) were elevated in 57.59% and 77.85% of the patients respectively. However, elevation of blood hematocrit was rare (1.27% ). (3) It was found that in the acute phase (0 - 5 days of the onset), serum dengue virus antibody IgM (DF-IgM) was positive in 63.54% of the patients (61/96), and 92.62% (113/122) of patients were dengue virus RNA ( DENA-RNA ) positive. (4) The rate of comorbidity in this study was 55.06% ( 87/158 ), including hypertension (27.22%) and type 2 diabetes (15.82%), which were the two most common co-morbidities. (5) All the patients were given supportive therapy to prevent complications. They were also isolated for more than 5 days after onset, and at least for 24 hours after subsidence of fever in addition. (6) The criteria for the diagnosis of severe dengue were fulfilled in 18 patients (11.39%). One patient died of massive hemorrhage from gastro-intestinal tract, and 1 patient voluntarily left hospital with untreated multiple organ dysfunction syndrome (MODS

  15. Neutron measurements in the stray field produced by 158 GeV c(-1) per nucleon lead ion beams.

    Science.gov (United States)

    Agosteo, S; Birattari, C; Foglio Para, A; Nava, E; Silari, M; Ulrici, L

    1998-12-01

    This paper discusses measurements carried out at CERN in the stray radiation field produced by 158 GeV c(-1) per nucleon 208Pb82+ ions. The purpose was to test and intercompare the response of several detectors, mainly neutron measuring devices, and to determine the neutron spectral fluence as well as the microdosimetric (absorbed dose and dose equivalent) distributions in different locations around the shielding. Both active instruments and passive dosimeters were employed, including different types of Andersson-Braun rem counters, a tissue equivalent proportional counter, a set of superheated drop detectors, a Bonner sphere system, and different types of ion chambers. Activation measurements with 12C plastic scintillators and with 32S pellets were also performed to assess the neutron yield of high energy lead ions interacting with a thin gold target. The results are compared with previous measurements and with measurements made during proton runs.

  16. A new measurement of $J/\\psi$ suppression in Pb-Pb collisions at 158 GeV per nucleon

    CERN Document Server

    Alessandro, Bruno; Arnaldi, R; Atayan, M; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Castanier, G; Castor, J; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Comets, M P; Constantinescu, S; Cortesc, P; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Fargeix, J; Force, P; Gallio, M; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Guber, F F; Guichard, A; Gulkanian, H R; Idzik, M; Jouan, D; Karavicheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; MacCormick, M; Macciotta, P; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, P; Pizzi, J R; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, E; Villatte, L; Willis, N; Wu, T

    2005-01-01

    We present a new measurement of J/psi production in Pb-Pb collisions at 158 GeV/nucleon, from the data sample collected in year 2000 by the NA50 Collaboration, under improved experimental conditions with respect to previous years. With the target system placed in vacuum, the setup was better adapted to study, in particular, the most peripheral nuclear collisions with unprecedented accuracy. The analysis of this data sample shows that the (J/ psi )/Drell-Yan cross-sections ratio measured in the most peripheral Pb-Pb interactions is in good agreement with the nuclear absorption pattern extrapolated from the studies of proton-nucleus collisions. Furthermore, this new measurement confirms our previous observation that the (J/ psi )/Drell-Yan cross-sections ratio departs from the normal nuclear absorption pattern for semicentral Pb-Pb collisions and that this ratio persistently decreases up to the most central collisions. (41 refs).

  17. A new measurement of $J/\\psi$ suppression in Pb-Pb collisions at 158 GeV per nucleon

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Comets, M P; Constantinescu, S; Cortese, P; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Fargeix, J; Force, P; Gallio, M; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Guber, F F; Guichard, A; Gulkanian, H R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; MacCormick, M; Macciotta, P; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N; Wu, T

    2005-01-01

    We present a new measurement of J/psi production in Pb-Pb collisions at 158 GeV/nucleon, from the data sample collected in year 2000 by the NA50 Collaboration, under improved experimental conditions with respect to previous years. With the target system placed in vacuum, the setup was better adapted to study, in particular, the most peripheral nuclear collisions with unprecedented accuracy. The analysis of this data sample shows that the (J/psi)/Drell-Yan cross-sections ratio measured in the most peripheral Pb-Pb interactions is in good agreement with the nuclear absorption pattern extrapolated from the studies of proton-nucleus collisions. Furthermore, this new measurement confirms our previous observations that the (J/psi)/Drell-Yan cross-sections ratio departs from the normal nuclear absorption pattern for semi-central Pb-Pb collisions and that this ratio persistently decreases up to the most central collisions.

  18. Baryon stopping and charged particle production from lead-lead collisions at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Toy, Milton Y. [Univ. of California, Los Angeles, CA (United States)

    1999-01-01

    Net proton (proton minus antiproton) and negative charge hadron spectra (h-) from central Pb+Pb collisions at 158 GeV per nucleon at the CERN Super Proton Synchrotron were measured and compared to spectra from central collisions of the lighter S+S system. Net baryon distributions were derived from those of net protons and net lambdas. Stopping, or rapidity shift with respect to the beam, of net protons and net baryons increase with system size. The mean transverse momentum of net protons also increase with system size. The h- rapidity density scales with the number of participant nucleons for nuclear collisions, where their is independent of system size. The dependence upon particle mass and system size is consistent with larger transverse flow velocity at midrapidity for central collisions of Pb+Pb compared to that of S+S.

  19. Scale-dependence of transverse momentum correlations in Pb-Au collisions at 158A GeV/c

    CERN Document Server

    Adamová, D; Antonczyk, D; Appelshäuser, H; Belaga, V; Bielcikova, S; Braun-Munzinger, P; Busch, O; Cherlin, A; Damjanovic, S; Dietel, T; Dietrich, L; Drees, A; Dubitzky, W; Esumi, S I; Filimonov, K; Fomenko, K; Fraenkel, Zeev; Garabatos, C; Glässel, P; Holeczek, J; Kushpil, V; Maas, A; Marín, A; Milosevic, J; Milov, A; Miskowiec, D; Panebratsev, Yu A; Petchenova, O; Petracek, V; Pfeiffer, A; Ploskon, M; Radomski, S; Rak, acn J; Ravinovich, I; Rehak, P; Sako, H; Schmitz, W; Sedykh, S; Shimansky, S; Stachel, J; Sumbera, M; Tilsner, H; Tserruya, Itzhak; Tsiledakis, G; Wessels, J P; Wienold, T; Wurm, J P; Xie, W; Yurevich, S; Yurevich, V

    2008-01-01

    We present results on transverse momentum correlations of charged particle pairs produced in Pb-Au collisions at 158$A$ GeV/$c$ at the Super Proton Synchrotron. The transverse momentum correlations have been studied as a function of collision centrality, angular separation of the particle pairs, transverse momentum and charge sign. We demonstrate that the results are in agreement with previous findings in scale-independent analyses at the same beam energy. Employing the two-particle momentum correlator $$ and the cumulative $p_t$ variable $x(p_t)$, we identify, using the scale-dependent approach presented in this paper, different sources contributing to the measured correlations, such as quantum and Coulomb correlations, elliptic flow and mini-jet fragmentation.

  20. Inclusive production of charged pions in p+C collisions at 158 GeV/c beam momentum

    Energy Technology Data Exchange (ETDEWEB)

    Alt, C.; Blume, C.; Bramm, R.; Dinkelaker, P.; Flierl, D.; Gazdzicki, M.; Kniege, S.; Kollegger, T.; Mitrovski, M.; Renfordt, R.; Stock, R.; Stroebele, H.; Wetzler, A.; Zaranek, J. [Universitaet Frankfurt, Fachbereich Physik, Frankfurt (Germany); Baatar, B.; Kolesnikov, V.I.; Malakhov, A.I.; Melkumov, G.L. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Barna, D.; Fodor, Z.; Palla, G.; Sikler, F.; Sziklai, J.; Veres, G.I.; Vesztergombi, G. [KFKI Research Institute for Particle and Nuclear Physics, Budapest (Hungary); Barr, G.; Pattison, C. [University of Oxford, Oxford (United Kingdom); Bartke, J.; Kornas, E.; Kowalski, M.; Rybicki, A. [Polish Academy of Sciences, The H. Niewodniczanski Institute of Nuclear Physics, Cracow (Poland); Betev, L.; Buncic, P.; Fischer, H.G.; Varga, D.; Wenig, S. [CERN, Geneva (Switzerland); Bialkowska, H.; Boimska, B.; Trubnikov, V. [Institute for Nuclear Studies, Warsaw (Poland); Bracinik, J.; Cerny, V.; Kreps, M. [Comenius University, Bratislava (Slovakia); Christakoglou, P.; Georgopoulos, G.; Panagiotou, A.D.; Petridis, A.; Vassiliou, M. [University of Athens, Department of Physics, Athens (Greece); Chvala, O.; Dolejsi, J. [Charles University, Faculty of Mathematics and Physics, Institute of Particle and Nuclear Physics, Prague (Czech Republic); Eckardt, V.; Schmitz, N.; Seyboth, P. [Max-Planck-Institut fuer Physik, Munich (Germany); Foka, P.; Friese, V.; Hoehne, C.; Kraus, I.; Sandoval, A.; Vranic, D. [Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt (Germany); Karev, A. [CERN, Geneva (Switzerland); Max-Planck-Inst. fuer Physik, Muenchen (Germany); Litov, L.; Makariev, M.; Mateev, M.; Panayotov, D. [Sofia University St. Kliment Ohridski, Atomic Physics Department, Sofia (Bulgaria); Szymanski, P. [CERN, Geneva (Switzerland); Inst. of Nuclear Studies, Warsaw (Poland)

    2007-03-15

    The production of charged pions in minimum bias p+C interactions is studied using a sample of 377000 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The data cover a phase space area ranging from 0 to 1.8 GeV/c in transverse momentum and from -0.1 to 0.5 in Feynman x{sub F}. Inclusive invariant cross sections are given on a grid of 270 bins per charge, thus offering for the first time a dense coverage of the projectile hemisphere and of the cross-over region into the target fragmentation zone. (orig.) NA Collaboration

  1. Critical fluctuations of the proton density in A+A collisions at 158A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Anticic, T.; Kadija, K.; Susa, T. [Rudjer Boskovic Institute, Zagreb (Croatia); Baatar, B.; Kolesnikov, V.I.; Malakhov, A.I.; Melkumov, G.L. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bartke, J.; Kowalski, M.; Rybicki, A. [Polish Academy of Science, H. Niewodniczanski Institute of Nuclear Physics, Cracow (Poland); Beck, H.; Blume, C.; Book, J.; Mitrovski, M.; Renfordt, R.; Rustamov, A.; Schuster, T.; Stock, R.; Stroebele, H. [Fachbereich Physik der Universitaet, Frankfurt (Germany); Betev, L.; Buncic, P.; Karev, A. [CERN, Geneva (Switzerland); Bialkowska, H.; Boimska, B. [National Center for Nuclear Research, Warsaw (Poland); Bogusz, M.; Cetner, T.; Grebieszkow, K.; Mackowiak-Pawlowska, M.; Peryt, W.; Pluta, J.; Slodkowski, M.; Szuba, M. [Warsaw University of Technology, Faculty of Physics, Warsaw (Poland); Botje, M.; Christakoglou, P.; Leeuwen, M. van [NIKHEF, Amsterdam (Netherlands); Chvala, O. [Charles University, Institute of Particle and Nuclear Physics, Prague (Czech Republic); Cramer, J.; Prindle, D. [University of Washington, Nuclear Physics Laboratory, Seattle, WA (United States); Eckardt, V.; Schmitz, N.; Seyboth, P. [Max-Planck-Institut fuer Physik, Munich (Germany); Fodor, Z.; Laszlo, A.; Palla, G.; Sikler, F.; Veres, G.I.; Vesztergombi, G. [Hungarian Academy of Sciences, Wigner Research Center for Physics, Budapest (Hungary); Foka, P.; Friese, V.; Hoehne, C.; Kresan, D.; Sandoval, A.; Vranic, D. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Gazdzicki, M. [Fachbereich Physik der Universitaet, Frankfurt (Germany); Jan Kochanowski University, Institute of Physics, Kielce (Poland); Makariev, M. [BAS, Institute for Nuclear Research and Nuclear Energy, Sofia (Bulgaria); Mateev, M. [Sofia University St. Kliment Ohridski, Atomic Physics Department, Sofia (Bulgaria); Mrowczynski, S.; Rybczynski, M.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University, Institute of Physics, Kielce (Poland); Panagiotou, A.D.; Vassiliou, M.; Antoniou, N.G.; Davis, N.; Diakonos, F.K. [University of Athens, Department of Physics, Athens (Greece); Puehlhofer, F. [Fachbereich Physik der Universitaet, Marburg (Germany); Roland, C.; Roland, G. [MIT, Cambridge, MA (United States); Skrzypczak, E. [University of Warsaw, Institute for Experimental Physics, Warsaw (Poland); Varga, D. [Eoetvoes Lorant University, Budapest (Hungary); Collaboration: (NA49 Collaboration)

    2015-12-15

    We look for fluctuations expected for the QCD critical point using an intermittency analysis in the transverse momentum phase space of protons produced around midrapidity in the 12.5 % most central C+C, Si+Si and Pb+Pb collisions at the maximum SPS energy of 158A GeV. We find evidence of power-law fluctuations for the Si+Si data. The fitted power-law exponent φ{sub 2} = 0.96{sub -0.25}{sup +0.38}(stat.)±0.16(syst.) is consistent with the value expected for critical fluctuations. Power-law fluctuations had previously also been observed in low-mass π{sup +}π{sup -} pairs in the same Si+Si collisions. (orig.)

  2. No evidence of association between Catechol-O-Methyltransferase (COMT Val158Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study

    Directory of Open Access Journals (Sweden)

    O'Donovan Michael C

    2004-06-01

    Full Text Available Abstract Background Several studies have suggested an association between the functional Val158Met polymorphism in the Catechol-O-Methyltransferase (COMT gene and neurocognitive performance. Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST and another study found an effect on processing speed and attention. Methods We set out to examine the association between the Val158Met polymorphism and performance on neurocognitive tasks including those tapping working memory, attention and speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task performance for each genotypic group was compared using analysis of variance. Results There was no evidence of association with performance on any of the neurocognitive tasks. Conclusions We conclude that Val158Met COMT genotype is not associated with neurocognitive performance in our sample.

  3. Modulation of the COMT Val158Met polymorphism on resting-state EEG power in postmenopausal healthy women

    Directory of Open Access Journals (Sweden)

    Silvia eSolis-Ortiz

    2015-04-01

    Full Text Available The catechol-O-methyltransferase (COMT Val158Met polymorphism impacts cortical dopamine levels and may influence cortical electrical activity in the human brain. This study investigated whether COMT genotype influences resting-state electroencephalogram (EEG power in the frontal, parietal and midline regions in healthy volunteers. EEG recordings were conducted in the resting-state in 13 postmenopausal healthy woman carriers of the Val/Val genotype and 11 with the Met/Met genotype. The resting EEG spectral absolute power in the frontal (F3, F4, F7, F8, FC3 and FC4, parietal (CP3, CP4, P3 and P4 and midline (Fz, FCz, Cz, CPz, Pz and Oz was analyzed during the eyes-open and eyes-closed conditions. The frequency bands considered were the delta, theta, alpha1, alpha2, beta1 and beta2. EEG data of the Val/Val and Met/Met genotypes, brain regions and conditions were analyzed using a general linear model analysis. In the individuals with the Met/Met genotype, delta activity was increased in the eyes-closed condition, theta activity was increased in the eyes-closed and in the eyes-open conditions, and alpha1 band, alpha2 band and beta1band activity was increased in the eyes-closed condition.A significant interaction between COMT genotypes and spectral bands was observed. Met homozygote individuals exhibited more delta, theta and beta1 activity than individuals with the Val/Val genotype. No significant interaction between COMT genotypes and the resting-state EEG regional power and conditions were observed for the three brain regions studied. Our findings indicate that the COMT Val158Met polymorphism does not directly impact resting-state EEG regional power, but instead suggest that COMT genotype can modulate resting-state EEG spectral power in postmenopausal healthy women.

  4. Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network.

    Directory of Open Access Journals (Sweden)

    Tian Tian

    Full Text Available The effect of catechol-O-methyltransferase (COMT Val158Met polymorphism on brain structure and function has been previously investigated separately and regionally; this prevents us from obtaining a full picture of the effect of this gene variant. Additionally, gender difference must not be overlooked because estrogen exerts an interfering effect on COMT activity. We examined 323 young healthy Chinese Han subjects and analyzed the gray matter volume (GMV differences between Val/Val individuals and Met carriers in a voxel-wise manner throughout the whole brain. We were interested in genotype effects and genotype × gender interactions. We then extracted these brain regions with GMV differences as seeds to compute resting-state functional connectivity (rsFC with the rest of the brain; we also tested the genotypic differences and gender interactions in the rsFCs. Val/Val individuals showed decreased GMV in the posterior cingulate cortex (PCC compared with Met carriers; decreased GMV in the medial superior frontal gyrus (mSFG was found only in male Val/Val subjects. The rsFC analysis revealed that both the PCC and mSFG were functionally correlated with brain regions of the default mode network (DMN. Both of these regions showed decreased rsFCs with different parts of the frontopolar cortex of the DMN in Val/Val individuals than Met carriers. Our findings suggest that the COMT Val158Met polymorphism modulates both the structure and functional connectivity within the DMN and that gender interactions should be considered in studies of the effect of this genetic variant, especially those involving prefrontal morphology.

  5. Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers

    Science.gov (United States)

    Gibbs, Ayana A.; Bautista, Carla E.; Mowlem, Florence D.; Naudts, Kris H.; Duka, Dora T.

    2014-01-01

    Background Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has pleiotropic effects on cognitive and emotional processing. The met allele has been associated with enhanced cognitive processing but impaired emotional processing relative to the val allele. Methods We genotyped healthy, white men in relation to the COMT val158met polymorphism. They were given a single 4 mg dose of the selective noradrenaline reuptake inhibitor (NRI) reboxetine or placebo in a randomized, double-blind between-subjects model and then completed an emotional memory task 2 hours later. Results We included 75 men in the study; 41 received reboxetine and 34 received placebo. In the placebo group, met/met carriers did not demonstrate the usual memory advantage for emotional stimuli that was observed in val carriers. Reboxetine restored this emotional enhancement of memory in met/met carriers, but had no significant effect in val carriers. Limitations We studied only men, thus limiting the generalizability of our findings. We also relied on self-reported responses to screening questions to establish healthy volunteer status, and in spite of the double-blind design, participants were significantly better than chance at identifying their intervention allocation. Conclusion Emotional memory is impaired in healthy met homozygotes and selectively improved in this group by reboxetine. This has potential translational implications for the use of reboxetine, which is currently licensed as an antidepressant in several countries, and edivoxetine, a new selective NRI currently in development. PMID:24467942

  6. Star formation rates from [C II] 158 μm and mid-infrared emission lines for starbursts and active galactic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Sargsyan, L.; Lebouteiller, V.; Weedman, D.; Barry, D.; Spoon, H. [Center for Radiophysics and Space Research, Cornell University, Ithaca, NY 14853 (United States); Samsonyan, A. [Byurakan Astrophysical Observatory, Byurakan 0213 (Armenia); Bernard-Salas, J. [Department of Physical Sciences, Open University, Milton Keynes MK7 6AA (United Kingdom); Houck, J., E-mail: sargsyan@isc.astro.cornell.edu, E-mail: dweedman@isc.astro.cornell.edu [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States)

    2014-07-20

    A summary is presented for 130 galaxies observed with the Herschel Photodetector Array Camera and Spectrometer instrument to measure fluxes for the [C II] 158 μm emission line. Sources cover a wide range of active galactic nucleus to starburst classifications, as derived from polycyclic aromatic hydrocarbon strength measured with the Spitzer Infrared Spectrograph. Redshifts from [C II] and line to continuum strengths (equivalent width (EW) of [C II]) are given for the full sample, which includes 18 new [C II] flux measures. Calibration of L([C II)]) as a star formation rate (SFR) indicator is determined by comparing [C II] luminosities with mid-infrared [Ne II] and [Ne III] emission line luminosities; this gives the same result as determining SFR using bolometric luminosities of reradiating dust from starbursts: log SFR = log L([C II)]) – 7.0, for SFR in M{sub ☉} yr{sup –1} and L([C II]) in L{sub ☉}. We conclude that L([C II]) can be used to measure SFR in any source to a precision of ∼50%, even if total source luminosities are dominated by an active galactic nucleus (AGN) component. The line to continuum ratio at 158 μm, EW([C II]), is not significantly greater for starbursts (median EW([C II]) = 1.0 μm) compared to composites and AGNs (median EW([C II]) = 0.7 μm), showing that the far-infrared continuum at 158 μm scales with [C II] regardless of classification. This indicates that the continuum at 158 μm also arises primarily from the starburst component within any source, giving log SFR = log νL{sub ν}(158 μm) – 42.8 for SFR in M{sub ☉} yr{sup –1} and νL{sub ν}(158 μm) in erg s{sup –1}.

  7. Quels conflits d'intérêts sont-ils constitutifs de gestion déloyale (art. 158 CP) ?

    OpenAIRE

    Deuel, Michael

    2013-01-01

    Ce travail examine quels types de conflits d'intérêts ont une pertinence pénale au regard de l’art. 158 CP relatif à la gestion déloyale. Les deux infractions décrites à l'art. 158 CP sont présentées et quatre types de conflits d'intérêts, pertinents dans le cas de conseils d'administration, sont décrits. Enfin, des situations dans lesquels ils peuvent constituer une infraction de gestion déloyale sont analysées.

  8. The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence

    OpenAIRE

    Nikolac, Matea; Šagud, Marina; Nedić, Gordana; Nenadić Šviglin, Korona; Mihaljević Peleš, Alma; Uzun, Suzana; Vuskan Čusa, Bjanka; Kozumplik, Oliver; Živković, Maja; Mustapić, Maja; Jakovljević, Miro; PAVLOVIĆ, Mladen; Muck-Šeler, Dorotea; Borovečki, Fran; Pivac, Nela

    2013-01-01

    The study elucidated the association between the COMT Val108/158Met polymorphism and smoking in patients with schizophrenia, patients with alcohol dependence and healthy control subjects. The stepwise logistic regression (odds ratio (OR)=1.56, 95% confidence interval (CI)=1.10–2.23, P=0.014) and the χ2 test (P=0.008) revealed that the COMT Val/Val genotype was significantly associated with smoking in healthy male subjects. Although the hypothesis of the study was that COMT Val108/158Met genot...

  9. 亚甲蓝染色法乳腺癌前哨淋巴结活检术158例分析%Analysis of 158 Cases of Sentinel Lymph Node Biopsy in Breast Cancer by Methylene Blue Staining Method

    Institute of Scientific and Technical Information of China (English)

    黄国兴; 苏国森; 李上芹; 湛建伟; 程少萍

    2016-01-01

    目的:分析研究亚甲蓝染色法乳腺癌前哨淋巴结活检术(SLNB)158例的检测结果,为临床手术治疗提供数据参考。方法选择乳腺癌患者158例,所有患者均给予亚甲蓝染色法 SLNB 术,观察并统计乳腺癌患者的年龄、肿瘤大小和位置、术前化疗情况以及腋窝淋巴结肿大情况。分析亚甲蓝染色法 SLNB 术对于乳腺癌前哨淋巴结(SLN)的检出情况,并分析影响乳腺癌 SLN 检出的危险因素。结果亚甲蓝染色法 SLNB 术检测乳腺癌SLN 的准确度为94.94%,敏感度为94.38%,特异度为95.65%,肿瘤大小>5 cm 及触及腋窝淋巴结肿大的 SLN 检出率均显著少于肿瘤大小≤5 cm 及未触及腋窝淋巴结肿大者(P 5 cm and hit axillary lymph node enlargement of SLN detection rate were significant-ly less than tumor size≤5 cm and not palpable axillary lymph nodes,the difference was statistically significant (P < 0. 05). Tumor size and axillary lymph nodes were the unfavorable factors for SLN detection in breast cancer. Conclusion Meth-ylene blue staining method was applied to SLNB operation,the detection value was higher,but the clinic should also pay at-tention to the unfavorable factors of SLN detection in breast cancer.

  10. Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification

    NARCIS (Netherlands)

    Hellingman, C.A.; Davidson, E.N.; Koevoet, W.; Vitters, E.L.; Berg, W.B. van den; Osch, G.J. van; Kraan, P.M. van der

    2011-01-01

    The aim of this study was to investigate the roles of Smad2/3 and Smad1/5/8 phosphorylation in transforming growth factor-beta-induced chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells (BMSCs) to assess whether specific targeting of different Smad signaling pathways offers

  11. COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China.

    Science.gov (United States)

    Ge, Lin; Wu, Hua-Yu; Pan, Shang-Ling; Huang, Ling; Sun, Peng; Liang, Qing-Hua; Pang, Guo-Fang; Lv, Ze-Ping; Hu, Cai-You; Liu, Cheng-Wu; Zhou, Xiao-Ling; Huang, Ling-Jin; Yin, Rui-Xing; Peng, Jun-Hua

    2015-01-01

    To see the possible relationship between COMT Val158Met polymorphism and blood pressure (BP) and serum lipid levels and its putative role in human longevity, we genotyped COMT Val158Met (rs4680) by PCR-RFLP for members from Bama long-lived families (BLF, n = 1538), Bama non-long-lived families (BNLF, n = 600), Pingguo (a county outside Bama region) long-lived families (PLF, n = 538) and Pingguo non-long-lived families (PNLF, n = 403) after anthropometric measures were collected and serum lipid levels were detected. The distribution of genotypes and alleles among four family groups was significantly different (all P pressure (SBP), pulse pressure (PP), total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) levels of GG genotype carriers were dramatically higher than non-GG carriers in BNLF (P pressure and lipids were observed between genotypes in BLF and PNLF (P > 0.05). Correlation analyses revealed that COMT Val158Met was mainly correlated negatively with SBP, diastolic blood pressure (DBP) and LDL-C in BNLF and negatively with TC level in BLF, BNLF and PLF. These data suggest that COMT Val158Met polymorphism may have more impact on the modulation of BP and lipid profiles in the average families than in the long-lived families in Bama region. The association between this SNP and other phenotypes (e.g. cognition) and its roles in the longevity in Bama area thus warrant further investigation.

  12. The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder

    DEFF Research Database (Denmark)

    Miskowiak, K W; Kjaerstad, H L; Støttrup, M M

    2017-01-01

    OBJECTIVES: Cognitive dysfunction affects a substantial proportion of patients with bipolar disorder (BD), and genetic-imaging paradigms may aid in the elucidation of mechanisms implicated in this symptomatic domain. The Val allele of the functional Val158Met polymorphism of the catechol-O-methyl...

  13. Catechol-O-Methyltransferase "Val[superscript 158]Met" Genotype, Parenting Practices and Adolescent Alcohol Use: Testing the Differential Susceptibility Hypothesis

    Science.gov (United States)

    Laucht, Manfred; Blomeyer, Dorothea; Buchmann, Arlette F.; Treutlein, Jens; Schmidt, Martin H.; Esser, Gunter; Jennen-Steinmetz, Christine; Rietschel, Marcella; Zimmermann, Ulrich S.; Banaschewski, Tobias

    2012-01-01

    Background: Recently, first evidence has been reported for a gene-parenting interaction (G x E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase ("COMT") "Val[superscript 158]Met" polymorphism as a genetic susceptibility factor. Moreover, the current study…

  14. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lachman, H.M.; Papolos, D.F.; Veit, S. [Albert Einstein College of Medicine, Bronx, NY (United States)] [and others

    1996-09-20

    Velo-cardio-facial-syndrome (VCFS) is a common congenital disorder associated with typical facial appearance, cleft palate, cardiac defects, and learning disabilities. The majority of patients have an interstitial deletion on chromosome 22q11. In addition to physical abnormalities, a variety of psychiatric illnesses have been reported in patients with VCFS, including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. The psychiatric manifestations of VCFS could be due to haploinsufficiency of a gene(s) within 22q11. One candidate that has been mapped to this region is catechol-O-methyltransferase (COMT). We recently identified a polymorphism in the COMT gene that leads to a valine{r_arrow}methionine substitution at amino acid 158 of the membrane-bound form of the enzyme. Homozygosity for COMT158{sup met} leads to a 3- to 4-fold reduction in enzymatic activity, compared with homozygotes for COMT158{sup met}. We now report that in a population of patients with VCFS, there is an apparent association between the low-activity allele, COMT158{sup met}, and the development of bipolar spectrum disorder, and in particular, a rapid-cycling form. 33 refs., 3 tabs.

  15. Pion freeze-out time in Pb plus Pb collisions at 158 AGeV/c studied via pi(-)/pi(+) and K-/K+ ratios

    NARCIS (Netherlands)

    Aggarwal, M. M.; Ahammed, Z.; Angelis, A. L. S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T. C.; Baba, P. V. K. S.; Badyal, S. K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K. B.; Bhatia, V. S.; Blume, C.; Bucher, D.; Buesching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M. P.; Delagrange, H.; Donni, P.; Majumdar, M. R. Dutta; El Chenawi, K.; Dubey, A. K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M. S.; Garpman, S.; Gavrishchuk, O.; Geurts, F. J. M.; Ghosh, T. K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H. H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B. W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Löhner, H.; Luquin, L.; Mahapatra, D. P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G. C.; Mohanty, B.; Mora, M.-J.; Morrison, D.; Mukhanova, T.; Mukhopadhyay, D. S.; Naef, H.; Nandi, B. K.; Nayak, S. K.; Nayak, T. K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Pavliouk, S.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Phatak, S. C.; Pinganaud, W.; Plasil, F.; Purschke, M. L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N. K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J. M.; Sambyal, S. S.; Santo, R.; Sato, S.; Schlagheck, H.; Schutz, Y.; Shabratova, G.; Shah, T. H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B. C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S. P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; v. d. Pijll, E. C.; Eijndhoven, N. V.; Nieuwenhuizen, G. J. v.; Vinogradov, A.; Viyogi, Y. P.; Vodopianov, A.; Voeroes, S.; Wyslouch, B.; Young, G. R.

    2006-01-01

    The effect of the final state Coulomb interaction on particles produced in Pb + Pb collisions at 158AGeV/c has been investigated in the WA98 experiment through the study of the pi(-)/pi(+) and K-/K+ ratios measured as a function of T-m- (m)0. While the ratio for kaons shows no significant T-m

  16. Azimuthal anisotropy of photon and charged particle emission in Pb-208+Pb-208 collisions at 158 center dot A GeV/c

    NARCIS (Netherlands)

    Aggarwal, MM; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Bathe, S; Batiounia, B; Bernier, T; Bhatia, VS; Blume, C; Bucher, D; Busching, H; Carlen, L; Chattopadhyay, S; Decowski, MP; Delagrange, H; Donni, P; Majumdar, MRD; Dubey, AK; El Chenawi, K; Enosawa, K; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Gupta, R; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Kamermans, R; Karadjev, K; Karpio, K; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Löhner, H; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Miake, Y; Mishra, GC; Mohanty, B; Mora, MJ; Morrison, D; Moukhanova, T; Mukhopadhyay, DS; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Peressounko, D; Phatak, SC; Pinganaud, W; Plasil, F; Purschke, ML; Rak, J; Raniwala, R; Raniwala, S; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sharma, A; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Sood, G; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A; Tykarski, L; van der Phjll, EC; van Eijndhoven, N; van Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Young, GR

    The azimuthal distributions of photons and charged particles with respect to the event plane are investigated as a function of centrality in Pb-208 + Pb-208 collisions at 158 (.) A GeV/c in the WA98 experiment at the CERN SPS. The anisotropy of the azimuthal distributions is characterized using a

  17. Impact parameter dependence of π ±, K±, p, overlinep, d and overlined production in Pb+Pb collisions at 158 A GeV

    Science.gov (United States)

    Kabana, Sonja; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Borer, K.; Bussière, A.; Dittus, F.; Elsener, K.; Gorodetzky, Ph.; Guillaud, J. P.; Hess, P.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Tuominiemi, J.; Weber, M.; NA52 Collaboration

    1999-12-01

    The impact parameter dependence of π ±, K±, p, overlinep, d and overlined yields produced in fixed target lead+lead collisions at 158 A GeV incident energy is presented. The particle yields are measured near zero transverse momentum and in the forward rapidity region.

  18. Zircon U-Pb ages of olivine pyroxenite xenolith from Hannuoba:Links between the 97-158 Ma basaltic under-plating and granulite-facies metamorphism

    Institute of Scientific and Technical Information of China (English)

    LIU Yongsheng; YUAN Honglin; GAO Shan; HU Zhaochu; WANG Xuance; LIU Xiaoming; LIN Wenli

    2004-01-01

    U-Pb zircon dating by LA-ICP-MS and SHRIMP for one olivine pyroxenite yields complex age populations including Mesozoic ages of 97-158 Ma and 228 ±8.7 Ma, Early Paleozoic ages of 418-427 Ma, Paleoproterozoic age of 1844±13 Ma, Neoarchean age of 2541 ± 54 Ma and middle Archean age of 3123 ± 4.4 Ma. The 97-158 Ma and 228 ± 8.7 Ma zircons show typical igneous oscillatory zonation in CL images, suggesting two episodes of magmatic events. Overlapping of the 97-158 Ma ages with that of granulite xenoliths indicates that the Mesozoic granulite-facies metamorphism was induced by heating from the basaltic underplating at the base of the lower crust. Both processes lasted at least from about 158 to 97 Ma. Ages of 418-427 Ma could be records of the subduction of Mongolia oceanic crust under the North China craton. Ages of 1.84 Ga,2.54 Ga and 3.12 Ga correspond to the three important crust-mantle evolutionary events in the North China craton,and imply preservation of Precambrian lower crust in the present-day lower crust.

  19. A 158 fs 5.3 nJ fiber-laser system at 1 mu m using photonic bandgap fibers for dispersion control and pulse compression

    DEFF Research Database (Denmark)

    Nielsen, C.K.; Jespersen, Kim Giessmann; Keiding, S.R.

    2006-01-01

    We demonstrate a 158 fs 5.3 nJ mode-locked laser system based on a fiber oscillator, fiber amplifier and fiber compressor. Dispersion compensation in the fiber oscillator was obtained with a solid-core photonic bandgap (SC-PBG) fiber spliced to standard fibers, and external compression is obtaine...

  20. 158例老年贫血患者骨髓细胞学检查结果分析%Bone marrow cytology examination results analysis of 158 case elderly anemia patients

    Institute of Scientific and Technical Information of China (English)

    占颖奇; 陈速

    2014-01-01

    Objective:Cytological analysis of characteristics of the patients with bone marrow anemia in the elderly, to investigate the causes of anemia, improvement of anemia in the elderly attention.Methods:A retrospective analysis of 158 cases of anemia in the elderly patients (≥ 60 years) bone marrow cytology results and clinical data were performed.Results:158 cases of 48 cases with anemia in the elderly patients with mild anemia (30.4%); moderate anemia in 71 cases (44.9%); 39 cases (24.7%) in severe anemia. Diagnosis of 136 cases (86.1%): among the 26 cases of megaloblastic anemia (16.5%); anemia of chronic disease in 23 cases (14.6%); 20 cases with iron deficiency anemia (12.7%); 13 cases of multiple myeloma (8.2%); 12 cases of acute leukemia (7.6%); 9 patients with thrombocytopenia (5.7%); infectious anemia in 7 cases (4.3%); 5 cases of chronic lymphocytic leukemia (3.2%); 5 cases of myelodysplastic syndrome (3.2%); 4 cases of hemolytic anemia (2.5%); 3 cases of lymphoma (1.9%); 3 cases of hypersplenism (1.9%); 2 cases of chronic myelogenous leukemia (1.3%); 2 cases of malignant tumors (1.3%); 1 cases with pure red cell aplasia (0.6%); 1 cases of bone marrow fibrosis (0.6%). 22 cases of unknown causes (13.9%).Conclusions: Anemia in the elderly complex etiology, onset occult, should be thought highly by the elderly and medical workers;Bone marrow cytology for diagnosis of anemia, anemia in elderly type determination has important clinical significance.%目的:分析老年贫血患者骨髓细胞学特点,探讨老年贫血病因,提高对老年贫血的重视。方法:回顾分析158例老年贫血患者(≥60岁)骨髓细胞学检查结果及临床资料。结果:158例老年贫血患者中轻度贫血48例(30.4%);中度贫血71例(44.9%);重度贫血39例(24.7%)。明确病因的有136例(86.1%):其中巨幼细胞性贫血26例(16.5%);慢性病贫血23例(14.6%);缺铁性贫血20例(12.7%);多发性骨髓瘤13例(8.2%)

  1. The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder

    Directory of Open Access Journals (Sweden)

    Bergström Jan

    2010-11-01

    Full Text Available Abstract Background Cognitive behavioral therapy (CBT represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fear responses. We have recently demonstrated that the ability to extinguish learned fear responses is associated with a functional genetic polymorphism (COMTval158met in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting. Methods We tested a possible effect of the COMTval158met polymorphism on the efficacy of CBT, in particular exposure-based treatment modules, in a sample of 69 panic disorder patients. Results We present evidence that panic patients with the COMTval158met met/met genotype may profit less from (exposure-based CBT treatment methods as compared to patients carrying at least one val-allele. No association was found with the 5-HTTLPR/rs25531 genotypes which is presented as additional material. Conclusions We were thus able to transfer findings on the effect of the COMTval158met polymorphism from an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Limitations of the study as well as possible clinical implications are discussed. Trial registration Clinical Trial Registry name: Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder (IP2. Registration Identification number: NCT00845260, http://www.clinicaltrials.gov/ct2/show/NCT00845260

  2. Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.

    Directory of Open Access Journals (Sweden)

    Hugh Ramsay

    Full Text Available OBJECTIVE: Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences. METHOD: Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses. RESULTS: While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype. CONCLUSION: The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.

  3. The val158met polymorphism of human catechol-O-methyltransferase (COMT affects anterior cingulate cortex activation in response to painful laser stimulation

    Directory of Open Access Journals (Sweden)

    Musso Francesco

    2010-05-01

    Full Text Available Abstract Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography. The functional val158met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI, PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT val158met polymorphism on the blood oxygen level-dependent (BOLD response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC, foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT val158met polymorphism on cerebral pain processing.

  4. Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation

    Science.gov (United States)

    Liu, Jia; Saito, Kan; Maruya, Yuriko; Nakamura, Takashi; Yamada, Aya; Fukumoto, Emiko; Ishikawa, Momoko; Iwamoto, Tsutomu; Miyazaki, Kanako; Yoshizaki, Keigo; Ge, Lihong; Fukumoto, Satoshi

    2016-01-01

    Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue; however, its role during tooth development is unclear. Here, we used cell culture and in vivo analyses to determine the role of GDF5 during tooth development. GDF5 and its associated BMP receptors are expressed at the protein and mRNA levels during postnatal tooth development, particularly at a stage associated with enamel formation. Furthermore, whereas BMP2 was observed to induce evidently the differentiation of enamel-forming ameloblasts, excess GDF5 induce mildly this differentiation. A mouse model harbouring a mutation in GDF5 (W408R) showed enhanced enamel formation in both the incisors and molars, but not in the tooth roots. Overexpression of the W408R GDF5 mutant protein was shown to induce BMP2-mediated mRNA expression of enamel matrix proteins and downstream phosphorylation of Smad1/5/8. These results suggest that mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-signalling. PMID:27030100

  5. One-, Two- and Three-Particle Distributions from 158 A GeV/c Central Pb+Pb Collisions

    CERN Document Server

    Aggarwal, M M; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bucher, D; Büsching, H; Carlén, L; Chattopadhyay, S; Decowski, M P; Delagrange, H; Dönni, P; Dutta-Majumdar, M R; El-Chenawi, K F; Enosawa, K; Fokin, S; Frolov, V; Ganti, M S; Garpman, S; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Karadzhev, K; Karpio, K; Kolb, B W; Kosarev, I; Kucheryaev, I; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Löhner, H; Mahapatra, D P; Man'ko, V; Martin, M; Martínez, G; Maksimov, A; Miake, Y; Mishra, G C; Mohanty, B; Mora, M J; Morrison, D; Mukhanova, T; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Nyanin, A; Nikitin, V; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, V P; Nystrand, J; Oskarsson, A; Otterlund, I; Peitzmann, T; Peressounko, D Yu; Petracek, V; Plasil, F; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Rao, N K; Reygers, K; Roland, G; Rosselet, L; Rufanov, I; Rubio, J M; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Sood, G; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A; Tykarski, L; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Young, G R

    2003-01-01

    Several hadronic observables have been studied in central 158 A GeV Pb+Pb collisions using data measured by the WA98 experiment at CERN: single negative pion and kaon production, as well as two- and three-pion interferometry. The Wiedemann-Heinz hydrodynamical model has been fitted to the pion spectrum, giving an estimate of the temperature and transverse flow velocity. Bose-Einstein correlations between two identified negative pions have been analysed as a function of kT, using two different parameterizations. The results indicate that the source does not have a strictly boost invariant expansion or spend time in a long-lived intermediate phase. A comparison between data and a hydrodynamical based simulation shows very good agreement for the radii parameters as a function of kT. The pion phase-space density at freeze-out has been measured and agrees well with the Tomasik-Heinz model. A large pion chemical potential close to the condensation limit of the pion mass seems to be excluded. The three-pion Bose-Ein...

  6. COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence

    Directory of Open Access Journals (Sweden)

    C. A. Bousman

    2010-01-01

    Full Text Available Catechol-O-methyltransferease (COMT metabolizes prefrontal cortex dopamine (DA, a neurotransmitter involved in executive behavior; the Val158Met genotype has been linked to executive dysfunction, which might increase sexual risk behaviors favoring HIV transmission. Main and interaction effects of COMT genotype and executive functioning on sexual risk behavior were examined. 192 sexually active nonmonogamous men completed a sexual behavior questionnaire, executive functioning tests, and were genotyped using blood-derived DNA. Main effects for executive dysfunction but not COMT on number of sexual partners were observed. A COMT x executive dysfunction interaction was found for number of sexual partners and insertive anal sex, significant for carriers of the Met/Met and to a lesser extent Val/Met genotypes but not Val/Val carriers. In the context of HIV and methamphetamine dependence, dopaminergic overactivity in prefrontal cortex conferred by the Met/Met genotype appears to result in a liability for executive dysfunction and potentially associated risky sexual behavior.

  7. $\\phi$ production in Pb-Pb collisions at 158 GeV/c per nucleon incident momentum

    CERN Document Server

    Alessandro, B; Arnaldi, R; Astruc, J; Atayan, M; Baglin, C; Baldit, A; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Bussière, A; Capelli, L; Caponi, V; Castanier, C; Castor, J I; Chaurand, B; Chevrot, I; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constans, N; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Ducroux, L; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigoryanm, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Da Silva, W; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Silva, S; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N

    2003-01-01

    The production of vector mesons phi , rho and omega has been measured in Pb-Pb collisions at 158 GeV/c per nucleon incident momentum at the CERN/SPS. The muon spectrometer of experiment NA50 detects phi , rho and omega mesons via their mu /sup +/ mu /sup -/ decay channel in the collision center of mass rapidity range 0

  8. Bright [CII] 158$\\mu$m emission in a quasar host galaxy at $z=6.54$

    CERN Document Server

    Bañados, E; Walter, F; Venemans, B P; Farina, E P; Fan, X

    2015-01-01

    The [CII] 158$\\mu$m fine-structure line is known to trace regions of active star formation and is the main coolant of the cold, neutral atomic medium. In this \\textit{Letter}, we report a strong detection of the [CII] line in the host galaxy of the brightest quasar known at $z>6.5$, the Pan-STARRS1 selected quasar PSO J036.5078+03.0498 (hereafter P036+03), using the IRAM NOEMA millimeter interferometer. Its [CII] and total far-infrared luminosities are $(5.8 \\pm 0.7) \\times 10^9 \\,L_\\odot$ and $(7.6\\pm1.5) \\times 10^{12}\\,L_\\odot$, respectively. This results in a $L_{[CII]} /L_{TIR}$ ratio of $\\sim 0.8\\times 10^{-3}$, which is at the high end for those found for active galaxies, though it is lower than the average found in typical main sequence galaxies at $z\\sim 0$. We also report a tentative additional line which we identify as a blended emission from the $3_{22} - 3_{13}$ and $5_{23} - 4_{32}$ H$_2$O transitions. If confirmed, this would be the most distant detection of water emission to date. P036+03 riva...

  9. EMA-CO方案治疗滋养细胞肿瘤158例临床分析

    Institute of Scientific and Technical Information of China (English)

    夏天

    2011-01-01

    滋养细胞肿瘤(GTN)是一组来缘于胎盘滋养细胞的肿瘤,包括侵蚀性葡萄胎、绒毛膜癌、胎盘部位滋养细胞肿瘤。1956年首次报到甲氨蝶呤(MTX)可治愈转移性绒毛膜癌以来,对于GTN的化学治疗已十分成熟并形成规范化模式。但对高危和耐药病例的治疗仍是探索的焦点。近20多年来,EMA-CO方案被滋养细胞肿瘤专家推荐治疗高危GTN的一线化疗选择。笔者总结分析了使用EMA.CO方案治疗的高危耐药GTN患者158例的临床资料,以期正确认识和使用该方案。现报道如下。

  10. EMA-CO方案治疗滋养细胞肿瘤158例临床分析

    Institute of Scientific and Technical Information of China (English)

    夏天

    2011-01-01

    @@ 滋养细胞肿瘤(GTN)是一组来缘于胎盘滋养细胞的肿瘤,包括侵蚀性葡萄胎、绒毛膜癌、胎盘部位滋养细胞肿瘤[1].1956年首次报到甲氨蝶吟(MTX)可治愈转移性绒毛膜癌以来,对于GTN的化学治疗已十分成熟并形成规范化模式.但对高危和耐药病例的治疗仍是探索的焦点[2].近20多年来,EMA-CO方案被滋养细胞肿瘤专家推荐治疗高危GTN的一线化疗选择[3].笔者总结分析了使用EMA-CO方案治疗的高危耐药GTN患者158例的临床资料,以期正确认识和使用该方案.现报道如下.

  11. Detailed analysis of two particle correlations in central Pb-Au collisions at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Antonczyk, D.

    2006-07-01

    This thesis presents a two-particle correlation analysis of the fully calibrated high statistics CERES Pb+Au collision data at the top SPS energy, with the emphasis on the pion-proton correlations and the event-plane dependence of the correlation radii. CERES is a dilepton spectrometer at CERN SPS. After the upgrade, which improved the momentum resolution and extended the detector capabilities to hadrons, CERES collected 30 million Pb+Au events at 158 AGeV in the year 2000. A previous Hanbury-Brown-Twiss (HBT) analysis of pion pairs in a subset of these data, together with the results obtained at other beam energies, lead to a new freeze-out criterion [AAA+03]. In this work, the detailed transverse momentum and event-plane dependence of the pion correlation radii, as well as the pion-proton correlations, are discussed in the framework of the blast wave model of the expanding fireball. Furthermore, development of an electron drift velocity gas monitor for the ALICE TPC sub-detector is presented. The new method of the gas composition monitoring is based on the simultaneous measurement of the electron drift velocity and the gas gain and is sensitive to even small variations of the gas mixture composition. Several modifications of the apparatus were performed resulting in the final drift velocity resolution of 0.3 permille. (orig.)

  12. Multistrange Hyperon Production in Pb+Pb collisions at 30, 40, 80 and 158 A$\\cdot$GeV

    CERN Document Server

    Mitrovski, Michael; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Fischer, H G; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wenig, S; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Mitrovski, Michael

    2004-01-01

    A non-monotonic energy dependence of the $K^{+} / \\pi^{+}$ ratio with a sharp maximum close to 30 A$\\cdot$GeV is observed in central Pb+Pb collisions. Within a statistical model of the early stage, this is interpreted as a sign of the phase transition to a QGP, which causes a sharp change in the energy dependence of the strangeness to entropy ratio. This observation naturally motivates us to study the production of multistrange hyperons ($\\Xi$, $\\Omega$) as a function of the beam energy. Furthermore it was suggested that the kinematic freeze-out of $\\Omega$ takes place directly at QGP hadronization. If this is indeed the case, the transverse momentum spectra of the $\\Omega$ directly reflect the transverse expansion velocity of a hadronizing QGP. In this report we show preliminary NA49 results on $\\Omega^{-}$ and $\\bar{\\Omega}^{+}$ production in central Pb+Pb collisions at 40 and 158 A$\\cdot$GeV and compare them to measurements of $\\Xi^{-}$ and $\\bar{\\Xi}^{+}$ production in central Pb+Pb collisions at 30, 40, ...

  13. Strangeness enhancement at mid-rapidity in Pb-Pb collisions at 158 GeV/c

    CERN Document Server

    Andersen, E; Armenise, N; Bakke, H; Bán, J; Barberis, D; Beker, H; Beusch, Werner; Bloodworth, Ian J; Böhm, J; Caliandro, R; Campbell, M; Cantatore, E; Carrer, N; Catanesi, M G; Chesi, Enrico Guido; Dameri, M; Darbo, G; Diaczek, A; Di Bari, D; Di Liberto, S; Earl, B C; Elia, D; Evans, D; Fanebust, K; Fini, R A; Fontaine, J C; Ftácnik, J; Ghidini, B; Grella, G; Guida, M; Heijne, Erik H M; Helstrup, H; Holme, A K; Huss, D; Jacholkowski, A; Jones, G T; Jovanovic, P; Jusko, A; Kachelhoffer, T; Kinson, J B; Kirk, A; Klempt, W; Knudsen, H; Knudson, K P; Králik, I; Lenti, V; Lietava, R; Loconsole, R A; Løvhøiden, G; Lupták, M; Mack, V; Manzari, V; Martinengo, P; Mazzoni, M A; Meddi, F; Michalon, A; Michalon-Mentzer, M E; Middelkamp, P; Morando, M; Muciaccia, M T; Nappi, E; Navach, F; Norman, P I; Osculati, B; Pastircák, B; Pellegrini, F; Píska, K; Posa, F; Quercigh, Emanuele; Ricci, R A; Romano, G; Rosa, G; Rossi, L; Rotscheidt, Herbert; Safarík, K; Saladino, S; Salvo, C; Sándor, L; Segato, G F; Sené, M; Sené, R; Simone, S; Snoeys, W; Staroba, P; Szafran, S; Thompson, M; Thorsteinsen, T F; Tomasicchio, G; Torrieri, G D; Tveter, T S; Urbán, J; Venables, M; Villalobos Baillie, O; Virgili, T; Volte, A; Votruba, M F; Závada, P

    1999-01-01

    $K^{0}_{s}$, $\\Lambda$, $\\Xi$, $\\Omega$ and negative particle yields and transverse mass spectra have been measured at central rapidity in Pb-Pb and p-Pb collisions at 158 $A$ GeV/$c$. The yields in Pb-Pb interactions % are presented as a function of the collision centrality and compared with those obtained from p-Pb collisions. Strangeness enhancement in Pb-Pb relative to p-Pb collisions increases with the strangeness content of the particle. Going from p-Pb to Pb-Pb, the strange particle yields increase faster than linearly with the number of participants $N_{part}$ up to $N_{part} \\approx 100$, thereafter the increase becomes %linear with $N_{part}$. Yields are studied as a function of the number of nucleons participating in the collision $N_{part}$, which is estimated with the Glauber model. From p-Pb to Pb-Pb collisions the particle yields per participant increase substantially. The enhancement is more pronounced for multistrange particles, and exceeds an order of magnitude for the $\\Omega$. For a number...

  14. COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making.

    Science.gov (United States)

    He, Qinghua; Xue, Gui; Chen, Chuansheng; Lu, Zhong-Lin; Chen, Chunhui; Lei, Xuemei; Liu, Yuyun; Li, Jin; Zhu, Bi; Moyzis, Robert K; Dong, Qi; Bechara, Antoine

    2012-01-01

    Both genetic and environmental factors have been shown to influence decision making, but their relative contributions and interactions are not well understood. The present study aimed to reveal possible gene-environment interactions on decision making in a large healthy sample. Specifically, we examined how the frequently studied COMT Val(158)Met polymorphism interacted with an environmental risk factor (i.e., stressful life events) and a protective factor (i.e., parental warmth) to influence affective decision making as measured by the Iowa Gambling Task. We found that stressful life events acted as a risk factor for poor IGT performance (i.e., high reward sensitivity) among Met carriers, whereas parental warmth acted as a protective factor for good IGT performance (i.e., higher IGT score) among Val/Val homozygotes. These results shed some new light on gene-environment interactions in decision making, which could potentially help us understand the underlying etiology of several psychiatric disorders associated with decision making impairment.

  15. Effects of FCGRIIIa-158V/F polymorphism on antibody-dependent cellular cytotoxicity activity of adalimumab.

    Science.gov (United States)

    Kimura, Koji; Kobayashi, Daigo; Hatoyama, Saori; Yamamoto, Mizuki; Takayanagi, Risa; Yamada, Yasuhiko

    2017-09-15

    The associations between the efficacy of IgG reagents and the FCGRIIIa-158V/F polymorphism (rs396991) have been investigated. Although the genotype frequencies in healthy Japanese have been reported, those have varied, as one study reported that the proportions of V/V, V/F, and F/F were 59.1%, 38.6%, and 2.3%, respectively, while another study found that they were 4%, 44%, and 52%, respectively. However, there are no known investigations of the association between the antibody-dependent cellular cytotoxicity (ADCC) activity of adalimumab (ADA), an IgG reagent, in combination with FcγRIIIa and the polymorphism. In this study, we analyzed healthy Japanese to clarify genotype frequency using a direct sequence method. In addition, we examined the association between the ADA-mediated ADCC activity and the polymorphism. Our results showed that the frequencies of the V/V, V/F, and F/F genotypes in healthy Japanese were 9.2%, 39.8%, and 51.0%, respectively. The average activity of ADA-mediated ADCC was 25.0%, 19.0%, and 13.3% in the V/V, V/F, and F/F genotypes, respectively. Then, the ADCC activity of V/V was significantly higher than that of F/F (p F polymorphism. © 2017 APMIS. Published by John Wiley & Sons Ltd.

  16. Differential influence of 5-HTTLPR - polymorphism and COMT Val158Met - polymorphism on emotion perception and regulation in healthy women.

    Science.gov (United States)

    Weiss, Elisabeth M; Freudenthaler, H Harald; Fink, Andreas; Reiser, Eva M; Niederstätter, Harald; Nagl, Simone; Parson, Walther; Papousek, Ilona

    2014-05-01

    Converging evidence indicates that a considerable amount of variance in self-estimated emotional competency can be directly attributed to genetic factors. The current study examined the associations between the polymorphisms of the Catechol-O-methyltransferase (COMT Met158Val) and the serotonin transporter (5-HTTLPR) and specific measures of the self-estimated effectiveness of an individual's emotion perception and regulation. Emotional competence was measured in a large sample of 289 healthy women by using the Self-report Emotional Ability Scale (SEAS), which includes two subscales for the assessment of emotion perception and regulation in the intra-personal domain and two subscales for the assessment of emotion perception and regulation in the inter-personal domain. Participants' reports of effective emotion regulation in everyday life were associated with the COMT Met-allele, with women homozygous for the Val-allele scoring lowest on this scale. Self-estimated effectiveness of emotion perception of the individual's own emotions was related to the 5-HTTLPR. Both homozygous groups (s/s and l/l) rated their intra-personal emotion perception less effective than participants in the heterozygous s/l group. Taken together, the results indicate that genetic variants of the COMT and 5HTTLPR genes are differentially associated with specific measures of the self-estimated effectiveness of an individual's emotion perception and regulation in the intra-personal domain.

  17. A mature galaxy cluster at z=1.58 around the radio galaxy 7C1753+6311

    CERN Document Server

    Cooke, E A; Stern, D; Rettura, A; Brodwin, M; Galametz, A; Wylezalek, D; Bridge, C; Conselice, C J; De Breuck, C; Gonzalez, A H; Jarvis, M

    2015-01-01

    We report on the discovery of a z=1.58 mature cluster around the high-redshift radio galaxy 7C1753+6311, first identified in the Clusters Around Radio-Loud AGN survey. Two-thirds of the excess galaxies within the central 1Mpc lie on a red sequence with a colour that is consistent with an average formation redshift of zf~3. We show that 80+/-6% of the red sequence galaxies in the cluster core are quiescent, while the remaining 20% are red due to dusty star formation. We demonstrate that the cluster has an enhanced quiescent galaxy fraction that is three times that of the control field. We also show that this enhancement is mass dependent: 91+/-9% of the M* >10^{10.5}Msun cluster galaxies are quiescent, compared to only 36+/-2% of field galaxies, whereas the fraction of quiescent galaxies with lower masses is the same in the cluster and field environments. The presence of a dense core and a well-formed, quiescent red sequence suggest that this is a mature cluster. This means that distant radio galaxies do not s...

  18. Energy dependence of multiplicity fluctuations in heavy ion collisions at 20A to 158A GeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, J; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Buncic, P; Cerny, V; Christakoglou, P; Chung, P; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Flierl, D; Fodor, Z; Foka, P; Friese, V; Gál, J; Gazdzicki, M; Genchev, V; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kikola, D; Kliemant, M; Kniege, S; Kolesnikov, V I; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Laszlo, A; Lacey, R; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Nicolic, V; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Peryt, W; Pikna, M; Pluta, J; Prindle, D; Pühlhofer, F; Renfordt, R; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Schuster, T; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Slodkowski, M; Stefanek, G; Stock, R; Strabel, C; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Szuba, M; Szymanski, P; Trubnikov, V; Utvic, M; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Wojtaszek, A; Yoo, I K; Zimányi, J

    2008-01-01

    Multiplicity fluctuations of positively, negatively and all charged hadrons in the forward hemisphere were studied in central Pb+Pb collisions at 20A, 30A, 40A, 80A and 158A GeV. The multiplicity distributions and their scaled variances $\\omega$ are presented in dependence of collision energy as well as of rapidity and transverse momentum. The distributions have bell-like shape and their scaled variances are in the range from 0.8 to 1.2 without any significant structure in their energy dependence. No indication of the critical point fluctuations are observed. The string-hadronic model UrQMD significantly overpredicts the mean, but approximately reproduces the scaled variance of the multiplicity distributions. The predictions of the statistical hadron-resonance gas model obtained within the grand-canonical and canonical ensembles disagree with the measured scaled variances. The narrower than Poissonian multiplicity fluctuations measured in numerous cases may be explained by the impact of conservation laws on f...

  19. System-size dependence of Λ and Ξ production in nucleus-nucleus collisions at 40A and 158A GeV measured at the CERN Super Proton Synchrotron

    NARCIS (Netherlands)

    Anticic, T.; Botje, M.A.J.|info:eu-repo/dai/nl/070139032; van Leeuwen, M.|info:eu-repo/dai/nl/250599171; Mischke, A.|info:eu-repo/dai/nl/325781435

    2009-01-01

    Results on Λ, Λ̅ , and Ξ- production in centrality selected Pb+Pb reactions at 40A and 158A GeV and in near-central C+C and Si+Si reactions at 158A GeV are presented. Transverse mass spectra, rapidity spectra, and multiplicities in dependence of the system size are discussed. Comparisons to

  20. Radical surgical treatment of pineal region tumors: report of 158 cases%松果体区肿瘤的手术治疗(附158例报告)

    Institute of Scientific and Technical Information of China (English)

    漆松涛; 樊俊; 张喜安; 方陆雄; 邱炳辉; 潘军

    2013-01-01

    Objective To investigate surgical strategies and key techniques of pineal region tumors.Methods The records of 158 patients with pineal region tumors surgically removed by occipital transtentorial approach,including their clinical data,surgical methods and follow-up results,were retrospectively reviewed.Results A gross total tumor removal was accomplished in 137 patients (86.7%),subtotal in 19 (12.0%),and partial in 2 (1.3%).The histological diagnosis was germ cell tumor in 52.5%,pineal parenchymal tumor in 11.4%,glioma in 18.4% and miscellaneous in 17.7%.The mortality and permanent morbidity were 1.9% and 18.4%,respectively.Early or delayed hydrocephalus occurred in 19 cases.Conclusions Radical surgery plays an important role in the management of pineal region tumors.Reasonable approach selection,developed knowledge about arachnoid membranes and deep veins in pineal region,and skilled microsurgical techniques are critical to achieve a safe tumor removal.%目的 探讨松果体区肿瘤的手术治疗策略和技术要点.方法 对采用枕部经小脑幕入路切除的158例松果体区肿瘤患者进行回顾性研究,总结分析其临床资料、手术方法及术后随访结果.结果 肿瘤全切除137例,次全切除19例,部分切除2例.病理证实生殖细胞肿瘤83例,松果体实质肿瘤18例,神经上皮肿瘤29例,其他类型肿瘤28例.术后死亡3例(1.9%),出现同向偏盲、眼球运动障碍等永久性并发症29例(18.4%).19例出现早期或迟发性脑积水.结论 手术切除是松果体区肿瘤的必要治疗手段,合理的手术入路、对松果体区蛛网膜及深静脉系统的深入了解以及娴熟的显微操作技巧,是保障手术安全有效的关键因素.

  1. 158 ORIGINAL ARTICLE

    African Journals Online (AJOL)

    boaz

    range of serious infections, including nosocomial pneumonia, bacteremia ... cysticfibrosis, neutropenia, recent surgery, trauma, mechanical ventilation, and previous therapy with ... culture bottles containing brain-heart infusion broth and then ...

  2. SAJCC 158.indd

    African Journals Online (AJOL)

    was conducted did not have any policies or procedures currently in place, but felt that this practice might be beneficial to ... This practice has, however, sparked some controversy among ... A qualitative inquiry approach, using content analysis, was used. .... of the meaning of the concept 'family-witnessed resuscitation' and.

  3. Association between the COMT Val158Met polymorphism and risk of cancer: evidence from 99 case–control studies

    Directory of Open Access Journals (Sweden)

    Zhou Q

    2015-10-01

    Full Text Available Quan Zhou, Yan Wang, Aihua Chen, Yaling Tao, Huamei Song, Wei Li, Jing Tao, Manzhen ZuoDepartment of Gynecology and Obstetrics, The People’s Hospital of Three Gorges University, The First People’s Hospital of Yichang, Yichang, People’s Republic of ChinaAbstract: Catechol-O-methyltransferase (COMT plays a central role in DNA repair and estrogen-induced carcinogenesis. Many recent epidemiologic studies have investigated the association between the COMT Val158Met polymorphism and cancer risk, but the results are inconclusive. In this study, we performed a meta-analysis to investigate the association between cancer susceptibility and COMT Val158Met in different genetic models. Overall, no significant associations were found between COMT Val158Met polymorphism and cancer risk (homozygote model: odds ratio [OR] =1.05, 95% confidence interval [CI] = [0.98, 1.13]; heterozygote model: OR =1.01, 95% CI = [0.98, 1.04]; dominant model: OR =1.02, 95% CI [0.97, 1.06], and recessive model: OR =1.03, 95% CI [0.97, 1.09]. In the subgroup ­analysis of cancer type, COMT Val158Met was significantly associated with increased risks of ­bladder cancer in recessive model, and esophageal cancer in homozygote model, heterozygote model, and dominant model. Subgroup analyses based on ethnicities, COMT Val158Met was significantly associated with increased risk of cancer in homozygote and recessive model among Asians. In addition, homozygote, recessive, and dominant models were significantly associated with increased cancer risk in the subgroup of allele-specific polymerase chain reaction genotyping. Significant associations were not observed when data were stratified by the source of the controls. In summary, this meta-analysis suggested that COMT Val158Met polymorphism might not be a risk factor for overall cancer risk, but it might be involved in cancer development at least in some ethnic groups (Asian or some specific cancer types (bladder and esophageal cell

  4. Differential Effects of the Catechol-O-Methyltransferase Val158Met Genotype on the Cognitive Function of Schizophrenia Patients and Healthy Japanese Individuals

    Science.gov (United States)

    Tsuchimine, Shoko; Yasui-Furukori, Norio; Kaneda, Ayako; Kaneko, Sunao

    2013-01-01

    Background The functional polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene has been associated with differences in prefrontal cognitive functions in patients with schizophrenia and healthy individuals. Several studies have indicated that the Met allele is associated with better performance on measures of cognitive function. We investigated whether the COMT Val158Met genotype was associated with cognitive function in 149 healthy controls and 118 patients with schizophrenia. Methods Cognitive function, including verbal memory, working memory, motor speed, attention, executive function and verbal fluency, was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS-J). We employed a one-way analysis of variance (ANOVA) and a multiple regression analysis to determine the associations between the COMT Val158Met genotype and the BACS-J measurements. Results The one-way ANOVA revealed a significant difference in the scores on the Tower of London, a measure of executive function, between the different Val158Met genotypes in the healthy controls (p = 0.023), and a post-hoc analysis showed significant differences between the scores on the Tower of London in the val/val genotype group (18.6 ± 2.4) compared to the other two groups (17.6 ± 2.7 for val/met and 17.1 ± 3.2 for met/met; p = 0.027 and p = 0.024, respectively). Multiple regression analyses revealed that executive function was significantly correlated with the Val158Met genotype (p = 0.003). However, no evidence was found for an effect of the COMT on any cognitive domains of the BACS-J in the patients with schizophrenia. Conclusion These data support the hypothesis that the COMT Val158Met genotype maintains an optimal level of dopamine activity. Further studies should be performed that include a larger sample size and include patients on and off medication, as these patients would help to confirm our findings. PMID:24282499

  5. Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals.

    Directory of Open Access Journals (Sweden)

    Shoko Tsuchimine

    Full Text Available BACKGROUND: The functional polymorphism Val158Met in the catechol-O-methyltransferase (COMT gene has been associated with differences in prefrontal cognitive functions in patients with schizophrenia and healthy individuals. Several studies have indicated that the Met allele is associated with better performance on measures of cognitive function. We investigated whether the COMT Val158Met genotype was associated with cognitive function in 149 healthy controls and 118 patients with schizophrenia. METHODS: Cognitive function, including verbal memory, working memory, motor speed, attention, executive function and verbal fluency, was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS-J. We employed a one-way analysis of variance (ANOVA and a multiple regression analysis to determine the associations between the COMT Val158Met genotype and the BACS-J measurements. RESULTS: The one-way ANOVA revealed a significant difference in the scores on the Tower of London, a measure of executive function, between the different Val158Met genotypes in the healthy controls (p = 0.023, and a post-hoc analysis showed significant differences between the scores on the Tower of London in the val/val genotype group (18.6 ± 2.4 compared to the other two groups (17.6 ± 2.7 for val/met and 17.1 ± 3.2 for met/met; p = 0.027 and p = 0.024, respectively. Multiple regression analyses revealed that executive function was significantly correlated with the Val158Met genotype (p = 0.003. However, no evidence was found for an effect of the COMT on any cognitive domains of the BACS-J in the patients with schizophrenia. CONCLUSION: These data support the hypothesis that the COMT Val158Met genotype maintains an optimal level of dopamine activity. Further studies should be performed that include a larger sample size and include patients on and off medication, as these patients would help to confirm our findings.

  6. Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Ryu Takizawa

    Full Text Available BACKGROUND: "Imaging genetics" studies have shown that brain function by neuroimaging is a sensitive intermediate phenotype that bridges the gap between genes and psychiatric conditions. Although the evidence of association between functional val108/158met polymorphism of the catechol-O-methyltransferase gene (COMT and increasing risk for developing schizophrenia from genetic association studies remains to be elucidated, one of the most topical findings from imaging genetics studies is the association between COMT genotype and prefrontal function in schizophrenia. The next important step in the translational approach is to establish a useful neuroimaging tool in clinical settings that is sensitive to COMT variation, so that the clinician could use the index to predict clinical response such as improvement in cognitive dysfunction by medication. Here, we investigated spatiotemporal characteristics of the association between prefrontal hemodynamic activation and the COMT genotype using a noninvasive neuroimaging technique, near-infrared spectroscopy (NIRS. METHODOLOGY/PRINCIPAL FINDINGS: Study participants included 45 patients with schizophrenia and 60 healthy controls matched for age and gender. Signals that are assumed to reflect regional cerebral blood volume were monitored over prefrontal regions from 52-channel NIRS and compared between two COMT genotype subgroups (Met carriers and Val/Val individuals matched for age, gender, premorbid IQ, and task performance. The [oxy-Hb] increase in the Met carriers during the verbal fluency task was significantly greater than that in the Val/Val individuals in the frontopolar prefrontal cortex of patients with schizophrenia, although neither medication nor clinical symptoms differed significantly between the two subgroups. These differences were not found to be significant in healthy controls. CONCLUSIONS/SIGNIFICANCE: These data suggest that the prefrontal NIRS signals can noninvasively detect the impact

  7. The catechol-O-methyltransferase (COMT val158met polymorphism affects brain responses to repeated painful stimuli.

    Directory of Open Access Journals (Sweden)

    Marco L Loggia

    Full Text Available Despite the explosion of interest in the genetic underpinnings of individual differences in pain sensitivity, conflicting findings have emerged for most of the identified "pain genes". Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT, as its substantial association to pain sensitivity has been reported in various studies, but rejected in several others. In line with findings from behavioral studies, we hypothesized that the effect of COMT on pain processing would become apparent only when the pain system was adequately challenged (i.e., after repeated pain stimulation. In the present study, we used functional Magnetic Resonance Imaging (fMRI to investigate the brain response to heat pain stimuli in 54 subjects genotyped for the common COMT val158met polymorphism (val/val = n 22, val/met = n 20, met/met = n 12. Met/met subjects exhibited stronger pain-related fMRI signals than val/val in several brain structures, including the periaqueductal gray matter, lingual gyrus, cerebellum, hippocampal formation and precuneus. These effects were observed only for high intensity pain stimuli after repeated administration. In spite of our relatively small sample size, our results suggest that COMT appears to affect pain processing. Our data demonstrate that the effect of COMT on pain processing can be detected in presence of 1 a sufficiently robust challenge to the pain system to detect a genotype effect, and/or 2 the recruitment of pain-dampening compensatory mechanisms by the putatively more pain sensitive met homozygotes. These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation.

  8. Catechol-O-methyltransferase Val158Met polymorphism on the relationship between white matter hyperintensity and cognition in healthy people.

    Directory of Open Access Journals (Sweden)

    Mu-En Liu

    Full Text Available BACKGROUND: White matter lesions can be easily observed on T2-weighted MR images, and are termed white matter hyperintensities (WMH. Their presence may be correlated with cognitive impairment; however, the relationship between regional WMH volume and catechol-O-methyltransferase (COMT Val158Met polymorphism in healthy populations remains unclear. METHODS: We recruited 315 ethnic Chinese adults with a mean age of 54.9 ± 21.8 years (range: 21-89 y to examine the genetic effect of COMT on regional WMH and the manner in which they interact to affect cognitive function in a healthy adult population. Cognitive tests, structural MRI scans, and genotyping of COMT were conducted for each participant. RESULTS: Negative correlations between the Digit Span Forward (DSF score and frontal WMH volumes (r = -.123, P = .032, uncorrected were noted. For the genetic effect of COMT, no significant difference in cognitive performance was observed among 3 genotypic groups. However, differences in WMH volumes over the subcortical region (P = .016, uncorrected, whole brain (P = .047, uncorrected, and a trend over the frontal region (P = .050, uncorrected were observed among 3 COMT genotypic groups. Met homozygotes and Met/Val heterozygotes exhibited larger WMH volumes in these brain regions than the Val homozygotes. Furthermore, a correlation between the DSF and regional WMH volume was observed only in Met homozygotes. The effect size (cohen's f revealed a small effect. CONCLUSIONS: The results indicate that COMT might modulate WMH volumes and the effects of WMH on cognition.

  9. Catechol-O-Methyltransferase Val158Met Polymorphism on the Relationship between White Matter Hyperintensity and Cognition in Healthy People

    Science.gov (United States)

    Liu, Mu-En; Huang, Chu-Chung; Yang, Albert C.; Tu, Pei-Chi; Yeh, Heng-Liang; Hong, Chen-Jee; Liou, Ying-Jay; Chen, Jin-Fan; Chou, Kun-Hsien; Lin, Ching-Po; Tsai, Shih-Jen

    2014-01-01

    Background White matter lesions can be easily observed on T2-weighted MR images, and are termed white matter hyperintensities (WMH). Their presence may be correlated with cognitive impairment; however, the relationship between regional WMH volume and catechol-O-methyltransferase (COMT) Val158Met polymorphism in healthy populations remains unclear. Methods We recruited 315 ethnic Chinese adults with a mean age of 54.9±21.8 years (range: 21–89 y) to examine the genetic effect of COMT on regional WMH and the manner in which they interact to affect cognitive function in a healthy adult population. Cognitive tests, structural MRI scans, and genotyping of COMT were conducted for each participant. Results Negative correlations between the Digit Span Forward (DSF) score and frontal WMH volumes (r = −.123, P = .032, uncorrected) were noted. For the genetic effect of COMT, no significant difference in cognitive performance was observed among 3 genotypic groups. However, differences in WMH volumes over the subcortical region (P = .016, uncorrected), whole brain (P = .047, uncorrected), and a trend over the frontal region (P = .050, uncorrected) were observed among 3 COMT genotypic groups. Met homozygotes and Met/Val heterozygotes exhibited larger WMH volumes in these brain regions than the Val homozygotes. Furthermore, a correlation between the DSF and regional WMH volume was observed only in Met homozygotes. The effect size (cohen’s f) revealed a small effect. Conclusions The results indicate that COMT might modulate WMH volumes and the effects of WMH on cognition. PMID:24551149

  10. No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

    Directory of Open Access Journals (Sweden)

    Stovner Lars

    2006-05-01

    Full Text Available Abstract Background The Catechol-O-methyltransferase (COMT gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype. Methods In the 1995–97 Nord-Trøndelag Health Study (HUNT, the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs was evaluated in a random sample of 3017 individuals. Results The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups. Conclusion In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.

  11. Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder

    Science.gov (United States)

    Park, Subin; Park, Jong-Eun; Yoo, Hee Jeong; Kim, Jae-Won; Cheong, Jae Hoon; Han, Doug Hyun; Kim, Yeni

    2015-01-01

    Objective We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios. Methods A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios. Results In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ2=4.21, p=0.040). Conclusion These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations. PMID:26508970

  12. SLAC's polarized electron source laser system and minimization of electron beam helicity correlations for the E-158 parity violation experiment

    Energy Technology Data Exchange (ETDEWEB)

    Humensky, T.B. E-mail: humensky@uchicago.edu; Alley, R.; Brachmann, A.; Browne, M.J.; Cates, G.D.; Clendenin, J.; Lamare, J. de; Frisch, J.; Galetto, T.; Hughes, E.W.; Kumar, K.S.; Mastromarino, P.; Sodja, J.; Souder, P.A.; Turner, J.; Woods, M

    2004-04-01

    SLAC E-158 is an experiment designed to make the first measurement of parity violation in Moeller scattering. E-158 will measure the right-left cross-section asymmetry, A{sub LR}{sup Moeller}, in the elastic scattering of a 45-GeV polarized electron beam from unpolarized electrons in a liquid hydrogen target. E-158 plans to measure the expected Standard Model asymmetry of {approx}10{sup -7} to an accuracy of better than 10{sup -8}. To make this measurement, the photoemission-based polarized electron source requires an intense circularly polarized laser beam and the ability to quickly switch between right- and left-helicity polarization states with minimal right-left helicity-correlated asymmetries in the resulting beam parameters (intensity, position, angle, spot size, and energy), {sup beam}A{sub LR}'s. This laser beam is produced by a unique SLAC-designed flashlamp-pumped Ti:Sapphire laser and is directed through a carefully designed set of polarization optics. We analyze the transport of nearly circularly polarized light through the optical system and identify several mechanisms that generate {sup beam}A{sub LR}'s. We show that the dominant effects depend linearly on particular polarization phase shifts in the optical system. We present the laser system design and a discussion of the suppression and control of {sup beam}A{sub LR}'s. We also present results on beam performance from engineering and physics runs for E-158.

  13. Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT

    Directory of Open Access Journals (Sweden)

    Zwart John-Anker

    2008-06-01

    Full Text Available Abstract Background The catechol-O-methyltransferase (COMT gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS in the general adult population. Methods In the Nord-Trøndelag Health Study (HUNT the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (≥ 8 and ≥ 11 were used to identify cases with anxiety (HADS-A and depression (HADS-D, whereas controls had HADS-A Results The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cut-off score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006. In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11 was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76. Conclusion In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding.

  14. No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population.

    Science.gov (United States)

    Tovilla-Zárate, Carlos; Medellín, Beatriz Camarena; Fresán, Ana; López-Narváez, Lilia; Castro, Thelma Beatriz Gonzalez; Juárez Rojop, Isela; Ramírez-Bello, Julián; Genis, Alma; Nicolini, Humberto

    2013-02-01

    The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. We determined the relation of the COMT Val108/158Met polymorphism with schizophrenia or its symptomatology (negative, disorganized and psychotic dimension). We conducted a case-control study comprising 186 patients with schizophrenia and 247 controls. The diagnosis of schizophrenia was established using the DSM-IV criteria for this illness. The clinical symptomatology was assessed through the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. No significant differences were found in the distribution of alleles (χ2 = 0.01, df = 1, p = 0.90) or genotypes (χ2 = 1.66, df = 2, p = 0.43) between schizophrenic patients and the control group. Multivariate analysis showed that the COMT Val108/158Met polymorphism has no influence in the clinical symptomatology of schizophrenia. Our results showed no association between COMT Val108/158Met and schizophrenia or evidence for an association between COMT and the clinical symptomatology of this illness. This suggests that the COMT gene may not contribute to the risk for schizophrenia among the Mexican population.

  15. The effects of catechol-O-methyl-transferase polymorphism Val158Met on functional connectivity in healthy young females: a resting EEG study.

    Science.gov (United States)

    Lee, Tien-Wen; Yu, Younger W-Y; Hong, Chen-Jee; Tsai, Shih-Jen; Wu, Hung-Chi; Chen, Tai-Jui

    2011-03-04

    The catechol-O-methyl-transferase (COMT) gene has been linked to a wide spectrum of human phenotypes, including cognition, affective response, pain sensitivity, anxiety and psychosis. This study examined the modulatory effects of COMT Val158Met on neural interactions, indicated by connectivity strengths. Blood samples and resting state eyes-closed EEG signals were collected in 254 healthy young females. The COMT Val158Met polymorphism was decoded into 3 groups: Val/Val, Val/Met and Met/Met. The values of mutual information of 20 frontal-related channel pairs across delta, theta, alpha and beta frequencies were analyzed based on the time-frequency mutual information method. Our one-way ANOVA analyses revealed that the significant connection-frequency pairs were relatively left lateralized (PF7-T3 and F7-C3 at delta frequency, and F3-F4, F7-T3, F7-C3, F7-P3, F3-C3, F3-F7 and F4-F8 at theta frequency. The F-test at F7-T3 and F7-C3 theta surpassed the statistical threshold of PVal/Met>Met/Met. Our analyses complemented previous literature regarding neural modulation by the COMT Val158Met polymorphism. The implication to the pathogenesis in schizophrenia was also discussed. Further studies are needed to clarify whether there is gender difference on this gene-brain interaction. Copyright © 2010 Elsevier B.V. All rights reserved.

  16. The catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects

    Science.gov (United States)

    Zhang, Xiaolong; Li, Jin; Qin, Wen; Yu, Chunshui; Liu, Bing; Jiang, Tianzi

    2015-01-01

    The influence of catechol-o-methyltransferase (COMT) Val158Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val158Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition. PMID:26054510

  17. Characterization of novel human papillomavirus types 157, 158 and 205 from healthy skin and recombination analysis in genus γ-Papillomavirus.

    Science.gov (United States)

    Bolatti, Elisa M; Chouhy, Diego; Casal, Pablo E; Pérez, Germán R; Stella, Emma J; Sanchez, Adriana; Gorosito, Mario; Bussy, Ramón Fernandez; Giri, Adriana A

    2016-08-01

    Gammapapillomavirus (γ-PV) is a diverse and rapidly expanding genus, currently consisting of 79 fully characterized human PV (HPV) types. In this study, three novel types, HPV157, HPV158 and HPV205, obtained from healthy sun-exposed skin of two immunocompetent individuals, were amplified by the "Hanging droplet" long PCR technique, cloned, sequenced and characterized. HPV157, HPV158 and HPV205 genomes comprise 7154-bp, 7192-bp and 7298-bp, respectively, and contain four early (E1, E2, E6 and E7) and two late genes (L1 and L2). Phylogenetic analysis of the L1 ORF placed all novel types within the γ-PV genus: HPV157 was classified as a new member of species γ-12 while HPV158 and HPV205 belong to species γ-1. We then explored potential recombination events in genus γ-PV with the RDP4 program in a dataset of 74 viruses (71 HPV types with available full-length genomes and the 3 novel types). Two events, both located in the E1 ORF, met the inclusion criterion (p-values genus γ-PV. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Carbon Chemistry in Transitional Clouds from the GOT C+ Survey of CII 158 micron Emission in the Galactic Plane

    Science.gov (United States)

    Langer, W. D.; Velusamy, T.; Pineda, J.; Willacy, K.; Goldsmith, P. F.

    2011-05-01

    In understanding the lifecycle and chemistry of the interstellar gas, the transition from diffuse atomic to molecular gas clouds is a very important stage. The evolution of carbon from C+ to C0 and CO is a fundamental part of this transition, and C+ along with its carbon chemistry is a key diagnostic. Until now our knowledge of interstellar gas has been limited primarily to the diffuse atomic phase traced by HI and the dense molecular H2 phase traced by CO. However, we have generally been missing an important layer in diffuse and transition clouds, which is denoted by the warm "dark gas'', that is mostly H2 and little HI and CO, and is best traced with C+. Here, we discuss the chemistry in the transition from C+ to C0 and CO in these clouds as understood by a survey of the CII 1.9 THz (158 micron) line from a sparse survey of the inner galaxy over about 40 degrees in longitude as part of the Galactic Observations of Terahertz C+ (GOT C+) program, a Herschel Space Observatory Open Time Key Program to study interstellar clouds by sampling ionized carbon. Using the first results from GOT C+ along 11 LOSs, in a sample of 53 transition clouds, Velusamy, Langer et al. (A&A 521, L18, 2010) detected an excess of CII intensities indicative of a thick H2 layer (a significant warm H2, "dark gas'' component) around the 12CO core. Here we present a much larger, statistically significant sample of a few hundred diffuse and transition clouds traced by CII, along with auxiliary HI and CO data in the inner Galaxy between l=-30° and +30°. Our new and more extensive sample of transition clouds is used to elucidate the time dependent physical and carbon chemical evolution of diffuse to transition clouds, and transition layers. We consider the C+ to CO conversion pathways such as H++ O and C+ + H2 chemistry for CO production to constrain the physical parameters such as the FUV intensity and cosmic ray ionization rate that drive the CO chemistry in the diffuse transition clouds.

  19. Lack of association of COMT Val158Met polymorphism with attention and executive function in patients with schizophrenia%精神分裂症COMT基因Val158Met多态性与注意力及执行功能缺乏关联

    Institute of Scientific and Technical Information of China (English)

    王强; 杨振兴; 梁林辉; 谷晓楚; 黄朝华; 李名立; 邓伟; 马小红; 王英成

    2014-01-01

    目的 探讨COMT基因Val158Met多态性与执行功能以及注意力之间的相关性.方法 采用连线测验评估103例精神分裂症患者(患者组)和99名正常对照(对照组)的注意力和执行功能;采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测COMT Val158 met各突变点的基因多态性并进行基因分型,用SPSS 13.0软件的一般线性模型分析COMT Val158Met多态性和执行功能以及注意力之间的相关性.结果 执行功能以及注意力在患者组和对照组中差异有统计学意义,而在三组基因型之间的差异无统计学意义.结论 COMT Val158Met多态性和执行功能以及注意力无相关性,主要原因可能是人群的异质性.%Objective To explore the association of a functional polymorphism Val158Met of COMT gene and attention and executive function in first-episode treatment-na(i)ve patients with schizophrenia and healthy controls.Method Trail making test (TMT) and clinical performances were evaluated in 103 firstepisode treatment-naive patients with schizophrenia and 99 healthy controls.Polymorphism of COMT Val158Met was analyzed using polymerase chain reaction-restriction fragment length polymorphism method.A general linear model was used to investigate the effect of genotype subgroups on the attention and executive function.Results There was a significant difference between control subjects and patients with schizophrenia on the TMT-A and B.However,no significant difference among Val/Val,Val/Met and Met/ Met on the TMT-A and B in control subjects and patients with schizophrenia was detected.Conclusion The association among COMTMet variant and trail making testing (attention and executive function) has been replicated.However,no association of COMTMet variant with disruption of dopaminergic influence on neurocognitive function was detected.This may be due to the heterogeneity of population.

  20. The Catechol-O-Methyltransferase Val158Met Polymorphism Contributes to the Risk of Breast Cancer in the Chinese Population: An Updated Meta-Analysis

    Science.gov (United States)

    Wan, Guo-Xing; Cao, Yu-Wen; Li, Wen-Qin; Li, Yu-Cong; Li, Feng

    2014-01-01

    Purpose Catechol-O-methyltransferase (COMT) enzyme plays a central role in estrogen-induced carcinogenesis. Emerging evidence from association studies has revealed that the functional Val158Met polymorphism (rs4680 G>A) of the Catechol-O-methyltransferase gene (COMT) has been implicated in susceptibility to breast cancer in the Chinese population, while results of individual published studies remain inconclusive and inconsistent. To assess this association in the Chinese population, a meta-analysis was performed. Methods Eligible studies were searched on MEDLINE, Embase, Cochrane Library, China National Knowledge Infrastructure, and the Chinese Biomedicine Database. Odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were pooled to assess the association between COMT polymorphisms and the risk of breast cancer using RevMan 5.2 and Stata 12.0 software. Results The meta-analysis included 14 eligible studies, with a total of 4,626 breast cancer cases and 5,637 controls. Overall, the COMT Val158Met polymorphism (rs4680 G>A) was significantly associated with an increased risk of breast cancer in several genetic models (A/A vs. G/G: OR, 1.59, 95% CI, 1.12-2.27; A/A vs. G/A+G/G: OR, 1.62, 95% CI, 1.14-2.29; A vs. G: OR, 1.15, 95% CI, 1.00-1.32), and a subgroup analysis according to menopausal status showed that this association was especially evident among premenopausal Chinese women (A/A vs. G/G: OR, 1.87, 95% CI, 0.99-3.54; A/A vs. G/A+G/G: OR, 1.94, 95% CI, 1.03-3.63). Conclusion The results of this meta-analysis indicated that COMT Val158Met variants contribute to breast cancer susceptibility in the Chinese population, particularly among premenopausal women. PMID:25013436

  1. COMT Val(158)Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.

    Science.gov (United States)

    Winkler, Ethan A; Yue, John K; Ferguson, Adam R; Temkin, Nancy R; Stein, Murray B; Barber, Jason; Yuh, Esther L; Sharma, Sourabh; Satris, Gabriela G; McAllister, Thomas W; Rosand, Jonathan; Sorani, Marco D; Lingsma, Hester F; Tarapore, Phiroz E; Burchard, Esteban G; Hu, Donglei; Eng, Celeste; Wang, Kevin K W; Mukherjee, Pratik; Okonkwo, David O; Diaz-Arrastia, Ramon; Manley, Geoffrey T

    2017-01-01

    Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransferase (COMT) is suggested to influence development of post-traumatic stress disorder (PTSD), but its role in TBI remains unclear. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether the COMT Val(158)Met polymorphism is associated with PTSD and global functional outcome as measured by the PTSD Checklist - Civilian Version and Glasgow Outcome Scale Extended (GOSE), respectively. Results in 93 predominately Caucasian subjects with mTBI show that the COMT Met(158) allele is associated with lower incidence of PTSD (univariate odds ratio (OR) of 0.25, 95% CI [0.09-0.69]) and higher GOSE scores (univariate OR 2.87, 95% CI [1.20-6.86]) 6-months following injury. The COMT Val(158)Met genotype and PTSD association persists after controlling for race (multivariable OR of 0.29, 95% CI [0.10-0.83]) and pre-existing psychiatric disorders/substance abuse (multivariable OR of 0.32, 95% CI [0.11-0.97]). PTSD emerged as a strong predictor of poorer outcome on GOSE (multivariable OR 0.09, 95% CI [0.03-0.26]), which persists after controlling for age, GCS, and race. When accounting for PTSD in multivariable analysis, the association of COMT genotype and GOSE did not remain significant (multivariable OR 1.73, 95% CI [0.69-4.35]). Whether COMT genotype indirectly influences global functional outcome through PTSD remains to be determined and larger studies in more diverse populations are needed to confirm these findings.

  2. Transverse momentum distribution of J/psi produced in Pb-Pb interactions at 158 GeV/c per nucleon

    CERN Document Server

    Abreu, M C; Alessandro, B; Astruc, J; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Bellaiche, F G; Bedjidian, Marc; Beolè, S; Boldea, V; Bordalo, P; Bussière, A; Capony, V; Castor, J I; Casagrande, L; Chambon, T; Chaurand, B; Chevrot, I; Cheynis, B; Chiavassa, E; Cicalò, C; Constantinescu, S; Comets, M P; Cruz, J; De Falco, A; Dellacasa, G; De Marco, N; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Filippov, S N; Fleuret, F; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; McCormick, M; Ohlsson-Malek, F; Marzari-Chiesa, A; Masera, M; Masoni, A; Mehrabyan, S S; Mourgues, S; Musso, A; Petiau, P; Silva, W L P; Piccotti, A; Pizzi, J R; Puddu, G; Quintans, C; Racca, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Sartori, S M; Saturnini, P; Scomparin, E; Shahoyan, R; Silva, S; Soave, C; Serci, S; Sonderegger, P; Tarrago, X; Temnikov, P; Topilskaya, N S; Usai, G L; Vale, C; Vercellin, Ermanno; Willis, N

    1999-01-01

    The production of dimuon in Pb-Pb collisions at 158 GeV/c per nucleon has been measured at the CERN SPS in experiment NA50. An anomalous suppression of J/psi production cross section has been observed in comparison with the value expected from the results obtained in proton and light ion induced reactions. An analysis of the transverse momentum distribution of J/psi is presented. For J/psi production, values have been calculated as a function of centrality.

  3. A Circumstantial Evidence for the Possible Production of QGP in the 158 AGeV/c Central Pb+Pb Collisions

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    One of the aims to research relativistic heavy-ion collisions is to explore the probability of quark-gluon plasma phase transition from normal nuclear matter. Hadron and string cascade model (JPCIAE) ,based on the hypothesis without introducing the quark-gluon plasma (QGP), is employed to study the direct photon and π 0 transverse momentum distributions for central 208Pb+208Pb collisions at 158 AGeV/c; The theoretical results of transverse momentum distribution for both the direct photon and the π0 particle are lower than the data of WA98 experiment. Having considered the fact that the

  4. $\\Lambda$ and $\\bar{\\Lambda}$ Production in Central Pb-Pb Collisions at 40, 80, and 158 A$\\cdot$GeV

    CERN Document Server

    Anticic, T; Collins, J; Dokshitzer, Y; Görlich, L; Grindhammer, G; Gustafson, G; Jönsson, L B; Jun, H; Kwiecinski, J; Levin, E; Lipatov, A V; Lönnblad, L; Lublinsk, M; Maul, M; Milcewicz, I; Miu, G; Nowak, G; Sjöstrand, Torbjörn; Stasto, A M; Timneanu, N; Turnau, J; Zotov, N P

    2003-01-01

    Production of Lambda and Antilambda hyperons was measured in central Pb-Pb collisions at 40, 80, and 158 A$\\cdot$GeV beam energy on a fixed target. Transverse mass spectra and rapidity distributions are given for all three energies. The $\\Lambda/\\pi$ ratio at mid-rapidity and in full phase space shows a pronounced maximum between the highest AGS and 40 A$\\cdot$GeV SPS energies, whereas the $\\bar{\\Lambda}/\\pi$ ratio exhibits a monotonic increase.

  5. Dopamine D3 Receptor Ser9Gly and Catechol-O-methyltransferase Val158Met Polymorphisms and Acute Pain in Sickle Cell Disease

    Science.gov (United States)

    Jhun, Ellie; He, Ying; Yao, Yingwei; Molokie, Robert E.; Wilkie, Diana J.; Wang, Zaijie Jim

    2014-01-01

    Background Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among SCD patients. In this study, we investigated the possible contribution of monoamine gene polymorphisms to pain variation. Methods Adult subjects with SCD completed PAINReportIt®, a computerized McGill Pain Questionnaire, from which we calculated the Composite Pain Index. Utilization data were obtained from the medical record and biweekly telephone calls for 12 months. Utilization is defined as admissions to the emergency department and/or the acute care center resulting from a sickle cell pain crisis. We performed genotyping for catechol-O-methyltransferase (COMT) Val158Met (rs4680) and dopamine D3 receptor(DRD3) Ser9Gly (rs6280) polymorphisms, which were analyzed for associations with pain phenotypes. Results Binary logistic models revealed that DRD3 Ser9Gly heterozygote patients were more likely not to have an acute pain crisis (odds ratio [OR] [95% confidence interval (CI)], 4.37 [1.39, 22.89]; p=0.020), which remained so when demographic variables were considered (OR [95% CI], 4.53 [1.41, 28.58]; p=0.016). COMT Val158Met Met allele showed lower probability for zero utilization (OR [95% CI], 0.32 [0.12, 0.83]; p=0.020) than the Val allele. In the negative binomial regression analysis, subjects with COMT Met/Met genotype had utilization incident rate ratio [95% CI] of 2.20 [1.21, 3.99] over those with Val/Val (p=0.010). Conclusions These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heterogeneity in SCD, as suggested by the different rates of acute pain crisis. Specifically, SCD patients with the DRD3 homozygote genotypes, COMT 158 Met allele or Met/Met genotype are more likely to have acute care utilization, an indicator of acute pain. These results, however, will need to be further examined in

  6. Directed and elliptic flow of charged pions and protons in Pb+Pb collisions at 40 and 158 AGeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, J; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Borghini, N; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Chvala, O; Cooper, G E; Cramer, J G; Csató, P; Dinh, P M; Dinkelaker, P; Eckardt, V; Filip, P; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Jacobs, P; Kadija, K; Karev, A; Kniege, S; Kolesnikov, V I; Kollegger, T; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Malakhov, A I; Markert, C; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Odyniec, Grazyna Janina; Ollitrault, J Y; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Pühlhofer, F; Reid, J G; Renfordt, R; Retyk, W; Ritter, H G; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R J; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2003-01-01

    Directed and elliptic flow measurements for charged pions and protons are reported as a function of transverse momentum, rapidity, and centrality for 40 and 158 AGeV Pb + Pb collisions as recorded by the NA49 detector. Both the standard method of correlating particles with an event plane, and the cumulant method of studying multiparticle correlations are used. In the standard method the directed flow is corrected for conservation of momentum. In the cumulant method elliptic flow is reconstructed from genuine 4, 6, and 8-particle correlations, showing the first unequivocal evidence for collective motion in A+A collisions at SPS energies.

  7. Electric charge fluctuations in central Pb+Pb collisions at 20A, 30A, 40A, 80A, and 158A GeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Van Leeuwen, M

    2004-01-01

    Results are presented on event-by-event electric charge fluctuations in central Pb+Pb collisions at 20A, 30A, 40A, 80A, and 158A GeV. The observed fluctuations are close to those expected for a gas of pions correlated by global charge conservation only. These fluctuations are considerably larger than those calculated for an ideal gas of deconfined quarks and gluons. The present measurements do not necessarily exclude reduced fluctuations from a quark-gluon plasma because these might be masked by contributions from resonance decays.

  8. Bose-Einstein correlations of charged kaons in central Pb + Pb collisions at $E_{beam}$ = 158 GeV per nucleon

    CERN Document Server

    Afanasiev, S V; Baatar, B; Barna, D; Bartke, Jerzy; Barton, R A; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Filip, P; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Igo, G; Jones, P G; Kadija, K; Karev, A; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lednicky, R; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Nelson, J M; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Squier, G T A; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Whitten, C; Yoo, I K; Zaranek, J; Zimányi, J; 10.1016/S0370-2693(03)00102-3

    2003-01-01

    Bose-Einstein correlations of charged kaons were measured near mid- rapidity in central Pb + Pb collisions at 158 A GeV by the NA49 experiment at the CERN SPS. Source radii were extracted using the Yano-Koonin-Podgoretsky and Bertsch-Pratt parameterizations. The results are compared to published pion and kaon data. The measured m /sub perpendicular to / dependence for kaons and pions is consistent with collective transverse expansion of the source and a freeze-out time of about 9.5 fm. (31 refs).

  9. Lambda and $\\overline{Lambda}$ production in central Pb-Pb collisions at 40, 80, and 158A GeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    Production of Lambda and Antilambda hyperons was measured in central Pb-Pb collisions at 40, 80, and 158A GeV beam energy on a fixed target. Transverse mass spectra and rapidity distributions are given for all three energies. The Lambda / pi ratio at midrapidity and in full phase space shows a pronounced maximum between the highest BNL Alternating Gradient Synchrotron and 40A GeV CERN Super Proton Synchrotron energies, whereas the Lambda / pi ratio exhibits a monotonic increase. (36 refs).

  10. Rapidity and transverse momentum dependence of pion-pion Bose-Einstein correlations measured at 20, 30, 40, 80, and 158 AGeV beam energy

    CERN Document Server

    Kniege, S; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Filip, P; Flierl, D; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Kniege, Stefan

    2004-01-01

    Preliminary results on pion-pion Bose-Einstein correlations in central Pb+Pb collisions measured by the NA49 experiment are presented. Rapidity as well as transverse momentum dependence of the HBT-radii are shown for collisions at 20, 30, 40, 80, and 158 AGeV beam energy. Including results from AGS and RHIC experiments only a weak energy dependence of the radii is observed. Based on hydrodynamical models parameters like lifetime and geometrical radius of the source are derived from the dependence of the radii on transverse momentum.

  11. Control Efficacy of Quizalofop-P-ethyl 15.8% EC against Bromus tectorum L.and Avena fatua L.in Spring Rape Fields%15.8%精喹禾灵EC对春油菜田旱雀麦、野燕麦的防治效果

    Institute of Scientific and Technical Information of China (English)

    魏有海; 翁华; 程亮

    2011-01-01

    为明确15.8%精喹禾灵EC对春油菜田禾本科杂草的防除效果及其使用的安全性,在田间设15.8%精喹禾灵EC每公顷225、300、375、600 mL 4个剂量处理,以15%精喹禾灵EC 300mL/hm为对照药剂,以人工锄草和清水喷雾为对照,于油菜2~5叶期(旱雀麦1~4叶期、野燕麦2~4叶期)对水300L喷雾处理,药后观察油菜和杂草的反应,20d、40d时调查杂草防效.试验结果表明,15.8%精喹禾灵EC对油菜田旱雀麦、野燕麦具有很好的防效,适宜剂量分别为375mL/hm、300mL/hm,此时防效均在80%以上,并且对油菜安全.因此,15.8%精喹未灵EC是防除油菜田旱雀麦和野燕麦的优良除草剂,可以在生产上推广使用.%The study revealed the control efficacy of Quizalofop-P-ethyl 15.8% EC against Bromus tectorumL.and Avena fatua L.as well as its safety in spring rape fields.The treatment included 225,300,375 and 600mL/ha of Quizalofop-P-ethyl 15.8% EC.The 300mL/ha of Quizalofop-P-ethyl 15% EC was used as herbicide control, and manual weeding and water were regarded as negative control.These herbicides were sprayed during 2-5 leaf stage of rape with 300 L water (1-4 leaf stage of Bromus tectorum L.and 2-4 leaf stage of Avena fatua L.).The incidence of weeds was investigated on the 20 th and 40 th days after the first spraying for calculating the control effects.The results of field trial showed that Quizalofop-P-ethyl 15.8% EC preformed well in controlling the weeds of Bromus tectorum L.and Avena fatua L.and the suitable dosages were 375mL/ha and 300mL/ha, respectively.Quizalofop-P-ethyl 15.8%EC effectively controlled Bromus tectorum L.and Avena fatua L.and could be used widely in spring rape fields.

  12. Mycelial glucoamylases produced by the thermophilic fungus Scytalidium thermophilum strains 15.1 and 15.8: purification and biochemical characterization Glucoamilases miceliais produzidas pelas linhagens 15.1 e 15.8 do fungo termofílico Scytalidium thermophilum: purificação e caracterização bioquímica

    Directory of Open Access Journals (Sweden)

    M.S. Ferreira-Nozawa

    2008-06-01

    Full Text Available Two strains (15.1 and 15.8 of the thermophilic fungus Scytalidium thermophilum produced high levels of intracellular glucoamylases, with potential for industrial applications. The isoform I of the glucoamylase produced by 15.1 strain was sequentially submitted to DEAE-Cellulose and CM-Cellulose chromatography, and purified 141-fold, with 5.45% recovery. The glucoamylase of strain 15.8 was purified 71-fold by CM-Cellulose and Concanavalin A-Sepharose chromatography, with 7.38% recovery. Temperature and pH optima were in the range of 50-60ºC and 5.0-6.0, respectively, using starch and maltose as substrates. The glucoamylase of S. thermophilum 15.8 was more stable (t50 > 60 min than that of S. thermophilum 15.1 (t50= 11-15 min, at 60ºC. The glucoamylase activities were enhanced by several ions (e.g. Mn2+ and Ca2+ and inhibited by β-mercaptoethanol. The glucoamylase from 15.1 strain showed a Km of 0.094 mg/ml and 0.029 mg/ml and Vmax of 202 U/mg prot and 109 U/mg prot, for starch and maltose, respectively. The hydrolysis products of starch and maltose, analyzed by TLC, demonstrated glucose as end product and confirming the character of the enzyme as glucoamylase. Differences were observed in relation to the products formed with maltose as substrate between the two strains studied. S. thermophilum 15.8 formed maltotriose in contrast with S. thermophilum 15.1.Duas linhagens (15.1 e 15.8 do fungo termofílico Scytalidium thermophilum se mostraram produtoras de grandes quantidades de glucoamilases, com potencial aplicação industrial. A isoforma I de glucoamilase produzida pela linhagem 15.1 foi submetida seqüencialmente a cromatografia em colunas de DEAE-celulose e CM-celulose, sendo purificada 141 vezes com porcentagem de recuperação de 5,45%. A glucoamilase da linhagem 15.8 foi purificada 71 vezes através do uso de colunas de cromatografia de CM-celulose e Concanavalina A-sepharose com porcentagem de recuperação de 7,38%. Temperatura e pH

  13. 长寿家系COMT Val158Met基因多态性及其与血压和血脂水平的相关性%Association of COMT Val158Met polymorphism with blood pressure and serum lipid levels in long-lived families

    Institute of Scientific and Technical Information of China (English)

    王艺苑; 庞国防; 罗桓; 胡才友; 潘尚领; 彭均华; 刘承武

    2015-01-01

    目的 探讨长寿家系COMT Val158Met(G>A)基因多态性与血压、血脂水平的相关性,了解其在长寿中的作用.方法 用PCR-RFLP方法对广西红水河流域长寿家系(HL)及非长寿家系(HNL)、外地区(平果)长寿(PL)及非长寿家系(PNL)的COMT Val158Met进行基因分型,分析该多态与血压和血脂水平的相关性.结果 等位基因A及其基因型(GA/AA)频率在HL和HNL间无差异,但高于PL和PNL(P <0.01).HL和PNL的血压、血脂水平在GA/AA和GG基因型携带者之间无差异,但HNL的GA/AA携带者的收缩压、脉压差、TC、TG及LDL-C水平明显高于GG携带者(P<0.05),尤以女性为甚,PL的部分结果与此类似.COMT Val158Met多态与HNL及PL的TC和LDL-C水平呈负相关(P< 0.05).结论 COMT Val158Met虽然在红水河流域人群中高频出现,但其对血压及血脂的影响主要在一般家系,对长寿家系的影响较小.

  14. Swift reveals a ~5.7 day super-orbital period in the M31 globular cluster X-ray binary XB158

    CERN Document Server

    Barnard, R; Murrray, S S

    2015-01-01

    The M31 globular cluster X-ray binary XB158 (a.k.a. Bo 158) exhibits intensity dips on a 2.78 hr period in some observations, but not others. The short period suggests a low mass ratio, and an asymmetric, precessing disk due to additional tidal torques from the donor star since the disk crosses the 3:1 resonance. Previous theoretical 3D smoothed particle hydrodynamical modeling suggested a super-orbital disk precession period 29$\\pm$1 times the orbital period, i.e. $\\sim$81$\\pm$3 hr. We conducted a Swift monitoring campaign of 30 observations over ~1 month in order to search for evidence of such a super-orbital period. Fitting the 0.3--10 keV Swift XRT luminosity lightcurve with a sinusoid yielded a period of 5.65+/-0.05 days, and a >5$\\sigma$ improvement in $\\chi^2$ over the best fit constant intensity model. A Lomb-Scargle periodogram revealed that periods 5.4--5.8 days were detected at a >3$\\sigma$ level, with a peak at 5.6 days. We consider this strong evidence for a 5.65 day super-orbital period, ~70\\% l...

  15. Artificial antigen-presenting cells expressing AFP(158-166) peptide and interleukin-15 activate AFP-specific cytotoxic T lymphocytes.

    Science.gov (United States)

    Sun, Longhao; Guo, Hao; Jiang, Ruoyu; Lu, Li; Liu, Tong; Zhang, Zhixiang; He, Xianghui

    2016-04-05

    Professional antigen-presenting cells (APCs) are potent generators of tumor antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive immunotherapy; however, generation of APCs is cumbersome, expensive, and subject to the tumor microenvironment. Artificial APCs (aAPCs) have been developed as a cost-effective alternative to APCs. We developed a cellular aAPC that efficiently generated alpha-fetoprotein (AFP)-specific CTLs. We genetically modified the human B cell lymphoma cell line BJAB with a lentiviral vector to establish an aAPC called BA15. The expression of AFP(158-166)-HLA-A*02:01 complex, CD80, CD86, and interleukin (IL)-15 in BA15 cells was assessed. The efficiency of BA15 at generating AFP-specific CTLs and the specific cytotoxicity of CTLs against AFP+ cells were also determined. BA15 cells expressed high levels of AFP(158-166) peptide, HLA-A2, CD80, CD86, and IL-15. BA15 cells also exhibited higher efficiency in generating AFP-specific CTLs than did dendritic cells. These CTLs had greater cytotoxicity against AFP+ hepatocellular carcinoma cells than did CTLs obtained from dendritic cells in vitro and in vivo. Our novel aAPC system could provide a robust platform for the generation of functional AFP-specific CTLs for adoptive immunotherapy of hepatocellular carcinoma.

  16. COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator.

    Science.gov (United States)

    Gao, Xiaoxue; Gong, Pingyuan; Liu, Jinting; Hu, Jie; Li, Yue; Yu, Hongbo; Gong, Xiaoliang; Xiang, Yang; Jiang, Changjun; Zhou, Xiaolin

    2016-05-01

    Individuals tend to avoid risk in a gain frame, in which options are presented in a positive way, but seek risk in a loss frame, in which the same options are presented negatively. Previous studies suggest that emotional responses play a critical role in this "framing effect." Given that the Met allele of COMT Val158Met polymorphism (rs4680) is associated with the negativity bias during emotional processing, this study investigated whether this polymorphism is associated with individual susceptibility to framing and which brain areas mediate this gene-behavior association. Participants were genotyped, scanned in resting state, and completed a monetary gambling task with options (sure vs risky) presented as potential gains or losses. The Met allele carriers showed a greater framing effect than the Val/Val homozygotes as the former gambled more than the latter in the loss frame. Moreover, the gene-behavior association was mediated by resting-state functional connectivity (RSFC) between orbitofrontal cortex (OFC) and bilateral amygdala. Met allele carriers showed decreased RSFC, thereby demonstrating higher susceptibility to framing than Val allele carriers. These findings demonstrate the involvement of COMT Val158Met polymorphism in the framing effect in decision-making and suggest RSFC between OFC and amygdala as a neural mediator underlying this gene-behavior association. Hum Brain Mapp 37:1880-1892, 2016. © 2016 Wiley Periodicals, Inc.

  17. Systematic decay studies of even-even $132-138$^Nd, $144-158$^Gd, $176-196$^Hg and $192-198$^Pb isotopes

    CERN Document Server

    Santhosh, K P

    2010-01-01

    The alpha and cluster decay properties of the $132-138$^Nd, $144-158$^Gd, $176-196$^Hg and $192-198$^Pb even-even isotopes in the two mass regions A = 130-158 and A = 180-198 are analysed using the Coulomb and Proximity Potential Model. On examining the clusters at corresponding points in the cold valleys (points with same A_2) of the various isotopes of a particular nucleus we find that at certain mass numbers of the parent nuclei, the clusters emitted are getting shifted to the next lower atomic number. It is interesting to see that the change in clusters appears at those isotopes where a change in shape is occurring correspondingly. Such a change of clusters with shape change is studied for the first time in cluster decay. The alpha decay half lives of these nuclei are computed and these are compared with the available experimental alpha decay data. It is seen that the two are in good agreement. On making a comparison of the alpha half lives of the normal deformed and super deformed nuclei, it can be seen ...

  18. Two-Channel Kondo Physics due to As Vacancies in the Layered Compound ZrAs1.58 Se0.39

    Science.gov (United States)

    Cichorek, T.; Bochenek, L.; Schmidt, M.; Czulucki, A.; Auffermann, G.; Kniep, R.; Niewa, R.; Steglich, F.; Kirchner, S.

    2016-09-01

    We address the origin of the magnetic-field-independent -|A |T1 /2 term observed in the low-temperature resistivity of several As-based metallic systems of the PbFCl structure type. For the layered compound ZrAs1.58 Se0.39 , we show that vacancies in the square nets of As give rise to the low-temperature transport anomaly over a wide temperature regime of almost two decades in temperature. This low-temperature behavior is in line with the nonmagnetic version of the two-channel Kondo effect, whose origin we ascribe to a dynamic Jahn-Teller effect operating at the vacancy-carrying As layer with a C4 symmetry. The pair-breaking nature of the dynamical defects in the square nets of As explains the low superconducting transition temperature Tc≈0.14 K of ZrAs1.58 Se0.39 compared to the free-of-vacancies homologue ZrP1.54 S0.46 (Tc≈3.7 K ). Our findings should be relevant to a wide class of metals with disordered pnictogen layers.

  19. Efficient utilization of hemicellulose and cellulose in alkali liquor-pretreated corncob for bioethanol production at high solid loading by Spathaspora passalidarum U1-58.

    Science.gov (United States)

    Yu, Hai; Guo, Jian; Chen, Yefu; Fu, Gengxin; Li, Baozhong; Guo, Xuewu; Xiao, Dongguang

    2017-02-11

    The bioethanol fermentation of pretreated corncob was investigated using Spathaspora passalidarum U1-58, which simultaneously utilizes glucose and xylose for high-efficiency ethanol production. Two approaches, namely, separate hydrolysis and co-fermentation (SHCF) and simultaneous saccharification and co-fermentation (SSCF), were optimized to test the ethanol fermentation potential of U1-58. The highest ethanol titer of 42.46g/L and yield of 72.12% were acquired in SHCF, whereas 53.24g/L ethanol and yield of 75.35% were obtained in SSCF at solid-to-liquid ratio of 1:5 (w/v). Approximately 86.20% of cellulose and 82.99% of hemicellulose were consumed in SSCF after 96h, and at least 10.49g/L ethanol was produced from hemicellulose, which corresponded to 37.59% of the theoretical yield. Compared with the published cellulosic ethanol fermentation cases, the present work presented high ethanol titer and yield, and cellulose and hemicellulose could be efficiently utilized for ethanol production.

  20. Measurement of resonance production in pion-carbon interactions at 158 and 350 GeV/c with NA61/SHINE

    Energy Technology Data Exchange (ETDEWEB)

    Herve, Alexander [KIT, Karlsruhe (Germany); Collaboration: NA61/SHINE-Collaboration

    2016-07-01

    The interpretation of extensive air shower measurements, produced by ultra-high energy cosmic rays, relies on the correct modelling of the hadron-air interactions that occur during the shower development. The majority of hadronic particles is produced at equivalent beam energies below the TeV range. NA61/SHINE is a fixed target experiment at the CERN Super Proton Synchrotron, studying hadron production in hadron-nucleus and nucleus-nucleus collisions to provide valuable contributions to a number of subjects, from neutrino through cosmic-ray to heavy-ion physics. Pion-Carbon interactions have been performed, at 158 and 350 GeV/c, to give precise particle production measurements for the most numerous projectile in air showers, the π meson. The ability to measure the production of resonances, such as the ρ{sup 0} and ω mesons, is particularly important to predict the number of muons produced in air showers. In this contribution we present updated results of resonance spectra at 158 and 350 GeV/c measured by NA61/SHINE.

  1. The first determination of Trichuris sp. from roe deer by amplification and sequenation of the ITS1-5.8S-ITS2 segment of ribosomal DNA.

    Science.gov (United States)

    Salaba, O; Rylková, K; Vadlejch, J; Petrtýl, M; Scháňková, S; Brožová, A; Jankovská, I; Jebavý, L; Langrová, I

    2013-03-01

    Trichuris nematodes were isolated from roe deer (Capreolus capreolus). At first, nematodes were determined using morphological and biometrical methods. Subsequently genomic DNA was isolated and the ITS1-5.8S-ITS2 segment from ribosomal DNA (RNA) was amplified and sequenced using PCR techniques. With u sing morphological and biometrical methods, female nematodes were identified as Trichuris globulosa, and the only male was identified as Trichuris ovis. The females were classified into four morphotypes. However, analysis of the internal transcribed spacers (ITS1-5.8S-ITS2) of specimens did not confirm this classification. Moreover, the female individuals morphologically determined as T. globulosa were molecularly identified as Trichuris discolor. In the case of the only male molecular analysis match the result of the molecular identification. Furthermore, a comparative phylogenetic study was carried out with the ITS1 and ITS2 sequences of the Trichuris species from various hosts. A comparison of biometric information from T. discolor individuals from this study was also conducted.

  2. β地中海贫血杂合子基因突变及Gγ珠蛋白基因-158位点SNP与Hb F的关系%β-thalassemia mutations and single nucleotide polymorphism at -158 of Gγ-globin gene associated with altered levels of Hb F in β-thalassemia heterozygotes

    Institute of Scientific and Technical Information of China (English)

    陈剑锋; 龙桂芳; 林伟雄; 陈萍

    2004-01-01

    目的探讨β地中海贫血(简称β地贫)杂合子基因突变类型和Gγ珠蛋白基因启动子-158位点(Gγ-158)单核苷酸多态性与胎儿血红蛋白(fetal hemoglobin, Hb F)水平的关系. 方法抗碱-比色法测定 Hb F水平;PCR-寡核苷酸斑点杂交法检测β地贫基因型;限制性内切酶Xmn Ⅰ消化经PCR扩增的Gγ基因启动子DNA片段,分析Gγ-158位点的单核苷酸多态性. 结果 63例受检的轻型β地贫中15例Hb F≥2%(2.06%~10.44%).共检出6种β地贫基因突变,分别是:CD41/42(-TTCT)、CD17(A→T)、nt-28(A→G)、CD71/72(+A)、IVS-II-654(C→T)、IVS-I-1(G→T).CD41/42、CD17、CD71/72、IVS-II-654的杂合子在15例Hb F升高组和48例Hb F正常组各自所占比例相同.63例个体中有10例为Gγ-158(C→T)突变的杂合子,总检出率为15.9%;其中15例高Hb F个体中检出8例(检出率53.33%), Hb F正常的48例检出2例(检出率4.17%),两组检出率差异有显著性(P<0.001). 结论β地贫基因突变CD41/42、CD17、CD71/72、IVS-II-654与β地贫杂合子的Hb F水平无关;而Gγ-158(C→T)突变与广西地区β地贫杂合子Hb F升高密切相关.

  3. Event-by-event fluctuations of the particle yield ratios in heavy-ion collisions at 20 - 158 AGeV

    Energy Technology Data Exchange (ETDEWEB)

    Kresan, Dmytro

    2010-12-22

    Non-statistical event-by-event fluctuations are considered as an important signal for the critical endpoint of the QCD phase diagram. Event-by-event fluctuations of different observables are thus investigated in detail in current experiments but are also an important observable to be studied at the future CBM experiment at FAIR. In this work we present the energy and centrality dependence of event-by-event fluctuations of particle yield ratios measured by the NA49 experiment in Pb+Pb collisions at 20-158 AGeV. Systematic studies of the influence of the dE/dx resolution on the particle identification and the centrality bin size were performed. Results can be compared to event-by-event fluctuations measured by NA49 for different observables such as or the mean charged particle multiplicity. Main results of these studies are an increase of absolute value of the dynamical particle ratio fluctuations with decreasing centrality for all considered ratios, saturation of the K/{pi} and K/p ratio fluctuations for peripheral Pb + Pb collisions at 158A GeV and scaling of the energy and centrality dependences of the p/{pi} ratio fluctuations with N{sub p}N{sub {pi}}. The measured energy and centrality dependences of the K/{pi} and K/p ratio fluctuations scale with N{sub K} in a different way. The saturation of the mentioned ratios fluctuations was attributed to the development of pronounced spike at zero in the eventwise ratio distributions, which, as was shown by Monte Carlo simulations, influence the measured fluctuations in the very peripheral Pb + Pb collisions at 158A GeV. In future, the CBM experiment at FAIR will investigate the intermediate region of the QCD phase diagram in great detail searching for the first order phase transition line and the expected critical endpoint. It is therefore important to closely investigate its sensitivity towards particle ratio fluctuations in Au+Au collisions at 10-45 AGeV beam energy. Detailed simulation studies are

  4. Neutron production from 158 GeV/c per nucleon lead ions on thin copper and lead targets in the angular range 30-135 degree

    CERN Document Server

    Silari, Marco; Birattari, C; Foglio-Para, A; Gini, L; Mitaroff, Angela; Ulrici, L

    2002-01-01

    The neutron emission from 5, 10 and 20 mm thick lead and 10 and 20 mm thick copper targets bombarded by a lead ion beam with momentum of 158 GeV/c per nucleon were measured at the CERN Super Proton Synchrotron. The neutron yield and spectral fluence per incident ion on target were measured with an extended range Bonner sphere spectrometer in the angular range 30-135 degree with respect to beam direction. Monte Carlo simulations with the FLUKA code were performed to establish a guess spectrum for the unfolding of the experimental data. The results have shown that, lacking Monte Carlo radiation transport codes dealing with ions with masses larger than 1 amu, a reasonable prediction can be carried out by scaling the result of a Monte Carlo calculation for protons by the projectile mass number to the power of 0.85-0.95 for a lead target and 0.88-1.03 for a copper target.

  5. L-band tunable external cavity laser based on 1.58 μm superluminescent diode integrated with spot-size converter.

    Science.gov (United States)

    Oh, Su Hwan; Yoon, Ki-Hong; Kim, Ki Soo; Kim, Jongbae; Kwon, O-Kyun; Oh, Dae Kon; Noh, Young-Ouk; Lee, Hyung-Jong

    2010-09-13

    We report a 1.58 μm superluminescent diode (SLD) with a spot-size converter (SSC) designed and fabricated as a light source for a tunable external cavity laser (T-ECL). The active section of the SLD is fabricated by using a planar buried heterostructure (PBH) for low-threshold current and high-output power operation at a low injection current. The SSC structure of the SLD is designed to possess a buried deep-ridge waveguide (BD-RWG) and show a beam of less divergence. The full-width at half maximum (FWHM) of the horizontal and vertical far-field patterns (FFPs), due to the beam of the less divergence, are 14° and 13°, respectively. We also confirm that an L-band T-ECL employing the SSC SLD operates well enough to prove the characteristics of high performance.

  6. COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.

    LENUS (Irish Health Repository)

    Boot, Erik

    2011-09-01

    Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2\\/3) R binding ratios (D(2\\/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2\\/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2\\/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.

  7. The ETFDH c.158A>G Variation Disrupts the Balanced Binding of ESE and ESS Proteins Causing Missplicing and Multiple acyl-CoA Dehydrogenation Deficiency

    DEFF Research Database (Denmark)

    Olsen, Rikke K J; Brøner, Sabrina; Sabaratnam, Rugivan

    2013-01-01

    Multiple acyl-CoA dehydrogenation deficiency is a disorder of fatty acid and amino acid oxidation caused by defects of electron transfer flavoprotein (ETF) or its dehydrogenase (ETFDH). A clear relationship between genotype and phenotype makes genotyping of patients important not only diagnostica......Multiple acyl-CoA dehydrogenation deficiency is a disorder of fatty acid and amino acid oxidation caused by defects of electron transfer flavoprotein (ETF) or its dehydrogenase (ETFDH). A clear relationship between genotype and phenotype makes genotyping of patients important not only......-down of nuclear proteins, we show that the c.158A>G variation increases the strength of a preexisting exonic splicing silencer (ESS) motif UAGGGA. This ESS motif binds splice inhibitory hnRNP A1, hnRNP A2/B1, and hnRNP H proteins. Binding of these inhibitory proteins prevents binding of the positive splicing...

  8. The Role of the Catechol-o-methyltransferase (COMT) Gene Val158Met in Aggressive Behavior, A Review of Genetic Studies

    Science.gov (United States)

    Qayyum, Arqam; Zai, Clement C.; Hirata, Yuko; Tiwari, Arun K.; Cheema, Sheraz; Nowrouzi, Behdin; Beitchman, Joseph H.; Kennedy, James L.

    2015-01-01

    Aggressive behaviors have become a major public health problem, and early-onset aggression can lead to outcomes such as substance abuse, antisocial personality disorder among other issues. In recent years, there has been an increase in research in the molecular and genetic underpinnings of aggressive behavior, and one of the candidate genes codes for the catechol-O-methyltransferase (COMT). COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. We will be reviewing the current literature on this gene variant in aggressive behavior. PMID:26630958

  9. On some properties of Deuteron and Antideuteron production in high energy lead-lead collisions at 158A GeV

    CERN Document Server

    Sau, Goutam

    2014-01-01

    We would attempt here to understand some properties of the transverse momentum ($p_T$) and rapidity ($y$) spectra on production of deuteron ($d$) and antideuteron($\\overline{d}$) in lead-lead $(Pb+Pb)$ collisions at 158A GeV recently reported by NA49 collaboration. Starting from some basic properties of $p+p$ reactions for production of secondary proton-antiprotons the cases of production of the composite set of particles, like $d$ and $\\overline{d}$, would be analysed. Some ratio-behaviours would also be dealt with in the light of the same approaches. It is found that the combination of the models put into use here capture modestly well the trends of the data on some important observables. Some limitations of the approach would also be pointed out in the end.

  10. Energy dependence of transverse momentum fluctuations in Pb+Pb collisions at the CERN Super Proton Synchrotron (SPS) at 20A to 158A GeV

    Energy Technology Data Exchange (ETDEWEB)

    NA49 Collaboration; Anticic, T.

    2009-04-15

    Results are presented on event-by-event fluctuations of transverse momenta p{sub T} in central Pb+Pb interactions at 20A, 30A, 40A, 80A, and 158A GeV. The analysis was performed for charged particles at forward center-of-mass rapidity (1.1 < y*{sub {pi}} < 2.6). Three fluctuation measures were studied: the distribution of average transverse momentum M(p{sub T}) in the event, the {phi}{sub p{sub T}} fluctuation measure, and two-particle transverse momentum correlations. Fluctuations of p{sub T} are small and show no significant energy dependence in the energy range of the CERN Super Proton Synchrotron. Results are compared with QCD-inspired predictions for the critical point, and with the UrQMD model. Transverse momentum fluctuations, similar to multiplicity fluctuations, do not show the increase expected for freeze-out near the critical point of QCD.

  11. Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells.

    Science.gov (United States)

    Kim, Beom Su; Kang, Hyo-Jin; Park, Ji-Yun; Lee, Jun

    2015-01-09

    Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar bone marrow-derived mesenchymal stem cells (hABM-MSCs) remain largely unknown. We investigated the action of fucoidan on osteoblast differentiation in hABM-MSCs and its impact on signaling pathways. Its effect on proliferation was determined using the crystal violet staining assay. Osteoblast differentiation was evaluated based on alkaline phosphatase (ALP) activity and the mRNA expression of multiple osteoblast markers. Calcium accumulation was determined by Alizarin red S staining. We found that fucoidan induced hABM-MSC proliferation. It also significantly increased ALP activity, calcium accumulation and the expression of osteoblast-specific genes, such as ALP, runt-related transcription factor 2, type I collagen-α 1 and osteocalcin. Moreover, fucoidan induced the expression of bone morphogenetic protein 2 (BMP2) and stimulated the activation of extracellular signal-related kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase by increasing phosphorylation. However, the effect of fucoidan on osteogenic differentiation was inhibited by specific inhibitors of ERK (PD98059) and JNK (SP600125) but not p38 (SB203580). Fucoidan enhanced BMP2 expression and Smad 1/5/8, ERK and JNK phosphorylation. Moreover, the effect of fucoidan on osteoblast differentiation was diminished by BMP2 knockdown. These results indicate that fucoidan induces osteoblast differentiation through BMP2-Smad 1/5/8 signaling by activating ERK and JNK, elucidating the molecular basis of the osteogenic effects of fucoidan in hABM-MSCs.

  12. Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4 promoter methylation in very preterm children at school age

    Directory of Open Access Journals (Sweden)

    Cecil Ming Yeung Chau

    2014-12-01

    Full Text Available Children born very preterm are exposed to repeated neonatal procedures that induce pain and stress during hospitalization in the neonatal intensive care unit (NICU. The COMT Val158Met genotype is involved with pain sensitivity, and early life stress is implicated in altered expression of methylation of the serotonin transporter. We examined: (1 whether methylation of the serotonin transporter gene (SLC6A4 promoter differs between very preterm children and full-term controls at school age, (2 relationships with child behavior problems, and (3 whether the extent of neonatal pain exposure interacts with the COMT Val158Met genotype to predict SLC6A4 methylation at 7 years in the very preterm children. We examined the associations between the COMT genotypes, neonatal pain exposure (adjusted for neonatal clinical confounders, SLC6A4 methylation and behavior problems. Very preterm children had significantly higher methylation at 7/10 CpG sites in the SLC6A4 promoter compared to full-term controls at 7 years. Neonatal pain (adjusted for clinical confounders was significantly associated with total child behaviour problems on the Child Behavior Checklist (CBCL questionnaire (adjusted for concurrent stressors and 5HTTLPR genotype (p = 0.035. CBCL total problems was significantly associated with greater SLC6A4 methylation in very preterm children (p = 0.01. Neonatal pain (adjusted for clinical confounders and COMT Met/Met genotype were associated with SLC6A4 promoter methylation in very preterm children at 7 years (p = 0.001. These findings provide evidence that both genetic predisposition and early environment need to be considered in understanding susceptibility for developing behavioral problems in this vulnerable population.

  13. Translation initiation of the replication initiator repB gene of promiscuous plasmid pMV158 is led by an extended non-SD sequence.

    Science.gov (United States)

    López-Aguilar, Celeste; Ruiz-Masó, José A; Rubio-Lepe, Tania Samir; Sanz, Marta; del Solar, Gloria

    2013-07-01

    RepB is the pMV158-encoded protein that initiates rolling-circle replication of this promiscuous plasmid. Availability of RepB is rate-limiting for the plasmid replication process, and therefore the repB gene encoding the protein is subjected to strict control. Two trans-acting plasmid elements, CopG and the antisense RNAII, are involved in controlling the synthesis of the initiator at the transcriptional and translational level, respectively. In addition to this dual control of repB expression that senses and corrects fluctuations in plasmid copy number, proper availability of RepB also relies on the adequate functionality of the transcription and translation initiation regulatory signals. Translation of repB has been postulated to depend on an atypical ribosome binding site that precedes its start codon, although such a hypothesis has never been proved. To define sequences involved in translation of repB, several mutations in the translation initiation region of the repB mRNA have been characterized by using an Escherichia coli in vitro expression system wherein the synthesis of RepB was detected and quantified. We showed that translation of repB is not coupled to that of copG and depends only on its own initiation signals. The atypical ribosome binding site, as it was defined, is not involved in translation initiation. However, the sequence just upstream of the repB start codon, encompassing the proximal box of the atypical ribosome binding site and the four bases immediately downstream of it, is indeed important for efficient translation of repB. The high degree of conservation of this sequence among the rep genes of plasmids of the same pMV158 family supports its relevancy as a translation initiation signal in mRNAs without a recognizable Shine-Dalgarno sequence.

  14. Association of the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Anxiety-Related Traits: A Meta-Analysis

    Science.gov (United States)

    Lee, Lewina O.; Prescott, Carol A.

    2014-01-01

    Objectives The main goals of this study were: (i) to examine genotypic association of the COMT val158met polymorphism with anxiety-related traits via a meta-analysis; (ii) to examine sex and ethnicity as moderators of the association, and (iii) to evaluate whether the association differed by particular anxiety traits. Methods Association studies of the COMT val18met polymorphism and anxiety traits were identified from the PubMed or PsycInfo databases, conference abstracts and listserv postings. Exclusion criteria were: (a) pediatric samples, (b) exclusively clinical samples, and (c) samples selected for a non-anxiety phenotype. Standardized mean differences in anxiety between genotypes were aggregated to produce mean effect sizes across all available samples, and for subgroups stratified by sex and ethnicity (Caucasians vs. Asians). Construct-specific analysis was conducted to evaluate the association of COMT with neuroticism, harm avoidance, and behavioral inhibition. Results Twenty seven eligible studies (N=15,979) with available data were identified. Overall findings indicate sex-specific and ethnic-specific effects: Val homozygotes had higher neuroticism than Met homozygotes in studies of Caucasian males ( ES¯=0.13, 95%CI: 0.02 – 0.25, p = 0.03), and higher harm avoidance in studies of Asian males ( ES¯=0.43, 95%CI: 0.14 – 0.72, p = 0.004). No significant associations were found in women and effect sizes were diminished when studies were aggregated across ethnicity or anxiety traits. Conclusions: This meta-analysis provides evidence for sex and ethnicity differences in the association of the COMT val158met polymorphism with anxiety traits. Our findings contribute to current knowledge on the relation between prefrontal dopaminergic transmission and anxiety. PMID:24300663

  15. System-size and centrality dependence of charged kaon and pion production in nucleus-nucleus collisions at 40A GeV and 158A GeV beam energy

    NARCIS (Netherlands)

    Anticic, T.; Baatar, B.; Christakoglou, P.; van Leeuwen, M.; Wojtaszek-Szwarc, A.

    2012-01-01

    Measurements of charged pion and kaon production are presented in centrality selected Pb+Pb collisions at 40A GeV and 158A GeV beam energy as well as in semicentral C+C and Si+Si interactions at 40A GeV. Transverse mass spectra, rapidity spectra, and total yields are determined as a function of

  16. Impact parameter dependence of {pi}{sup {+-}}, K{sup {+-}}, p, p-bar, d and d-bar production in Pb+Pb collisions at 158 A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Kabana, Sonja; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Borer, K.; Bussiere, A.; Dittus, F.; Elsener, K.; Gorodetzky, Ph.; Guillaud, J.P.; Hess, P.; Klingenberg, R.; Linden, T.; Lohmann, K.D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Tuominiemi, J.; Weber, M

    1999-12-27

    The impact parameter dependence of {pi}{sup {+-}}, K{sup {+-}}, p, p-bar, d and d-bar yields produced in fixed target lead+lead collisions at 158 A GeV incident energy is presented. The particle yields are measured near zero transverse momentum and in the forward rapidity region.

  17. Impact parameter dependence of pi sup+-, K sup+-, p, p-bar, d and d-bar production in Pb+Pb collisions at 158 A GeV

    CERN Document Server

    Kabana, S; Arsenescu, R; Baglin, C; Beringer, J; Borer, K; Bussière, A; Dittus, F; Elsener, K; Gorodetzky, P; Guillaud, J P; Hess, P; Klingenberg, R; Lindén, T; Lohmann, K D; Mommsen, R K; Moser, U; Pretzl, K; Schacher, J; Stoffel, F; Tuominiemi, J; Weber, M

    1999-01-01

    The impact parameter dependence of pi sup+-, K sup+-, p, p-bar, d and d-bar yields produced in fixed target lead+lead collisions at 158 A GeV incident energy is presented. The particle yields are measured near zero transverse momentum and in the forward rapidity region.

  18. Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.

    Directory of Open Access Journals (Sweden)

    Sari Voutilainen

    Full Text Available BACKGROUND: The role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met in the Catechol-O-methyltransferase (COMT gene. METHODOLOGY AND FINDINGS: Our aim was to examine the role of COMT Val158Met polymorphism and interaction of this polymorphism with serum tHcy and folate concentration on the risk of acute coronary and events in middle-aged men from eastern Finland. A population-based prospective cohort of 792 men aged 46-64 years was examined as part of the Kuopio Ischaemic Heart Disease Risk Factor Study. During an average follow-up of 9.3 years, there were 69 acute coronary events in men with no previous history of CHD. When comparing the COMT low activity genotype with the others, we found an age and examination year adjusted hazard rate ratio (HRR of 1.73 (95% confidence interval (CI, 1.07-2.79, and an age, examination year, serum LDL and HDL cholesterol, and triglyceride concentration, systolic blood pressure and smoking adjusted HRR of 1.77 (95% CI, 1.05-2.77. Although serum tHcy concentration was not statistically significantly associated with acute coronary events (HRR for the highest third versus others 1.52, 95% CI, 0.93-2.49, subjects with both high serum tHcy and the COMT low activity genotype had an additionally increased adjusted risk of HRR 2.94 (95% CI 1.50-5.76 as compared with other men. CONCLUSIONS: This prospective cohort study suggests that the functional COMT Val158Met polymorphism is associated with increased risk of acute coronary events and it may interact with high serum tHcy levels.

  19. Explaining the [CII]158um Deficit in Luminous Infrared Galaxies - First Results from a Herschel/PACS Study of the GOALS Sample

    CERN Document Server

    Diaz-Santos, T; Charmandaris, V; Stierwalt, S; Murphy, E J; Haan, S; Inami, H; Malhotra, S; Meijerink, R; Stacey, G; Petric, A O; Evans, A S; Veilleux, S; van der Werf, P P; Lord, S; Lu, N; Howell, J H; Appleton, P; Mazzarella, J M; Surace, J A; Xu, C K; Schulz, B; Sanders, D B; Bridge, C; Chan, B H P; Frayer, D T; Iwasawa, K; Melbourne, J; Sturm, E

    2013-01-01

    We present the first results of a survey of the [CII]158um emission line in 241 luminous infrared galaxies (LIRGs) comprising the Great Observatories All-sky Survey (GOALS) sample, obtained with the PACS instrument on board Herschel. The [CII] luminosities of the LIRGs in GOALS range from ~10^7 to 2x10^9 Lsun. We find that LIRGs show a tight correlation of [CII]/FIR with far-IR flux density ratios, with a strong negative trend spanning from ~10^-2 to 10^-4, as the average temperature of dust increases. We find correlations between the [CII]/FIR ratio and the strength of the 9.7um silicate absorption feature as well as with the luminosity surface density of the mid-IR emitting region (Sigma_MIR), suggesting that warmer, more compact starbursts have substantially smaller [CII]/FIR ratios. Pure star-forming (SF) LIRGs have a mean [CII]/FIR ~ 4x10^-3, while galaxies with low 6.2um PAH equivalent widths (EWs), indicative of the presence of active galactic nuclei (AGN), span the full range in [CII]/FIR. However, we...

  20. The VMC Survey XXII. Hierarchical Star Formation in the 30 Doradus-N158-N159-N160 Star-Forming Complex

    CERN Document Server

    Sun, Ning-Chen; Subramanian, Smitha; Cioni, Maria-Rosa L; Rubele, Stefano; Bekki, Kenji; Ivanov, Valentin D; Piatti, Andrés E; Ripepi, Vincenzo

    2016-01-01

    We study the hierarchical stellar structures in a $\\sim$1.5 deg$^2$ area covering the 30 Doradus-N158-N159-N160 star-forming complex with the VISTA Survey of the Magellanic Clouds. Based on the young upper main-sequence stars, we find that the surface densities cover a wide range of values, from log($\\Sigma\\cdot$pc$^2$) $\\lesssim$ $-$2.0 to log($\\Sigma\\cdot$pc$^2$) $\\gtrsim$ 0.0. Their distributions are highly non-uniform, showing groups that frequently have sub-groups inside. The sizes of the stellar groups do not exhibit characteristic values, and range continuously from several parsecs to more than 100 pc; the cumulative size distribution can be well described by a single power law, with the power-law index indicating a projected fractal dimension $D_2$ = 1.6 $\\pm$ 0.3. We suggest that the phenomena revealed here support a scenario of hierarchical star formation. Comparisons with other star-forming regions and galaxies are also discussed.

  1. Source radii at target rapidity from two-proton and two-deuteron correlations in central Pb+Pb collisions at 158 A GeV

    CERN Document Server

    Aggarwal, M M; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Dubey, A.K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Liu, H.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.-J.; Morrison, D.; Moukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Pavliouk, S.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Petracek, V.; Pinanaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.-R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; van de Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voros, S.; Wyslouch, B.; Young, G.R.

    2007-01-01

    Two-proton and two-deuteron correlations have been studied in the target fragmentation region of central Pb+Pb collisions at 158 A GeV. Protons and deuterons were measured with the Plastic Ball spectrometer of the WA98 experiment at the CERN SPS. The results of one-dimensional and multi-dimensional analyses using both the Bertsch-Pratt and Yano-Koonin-Podgoretsky parameterizations of the two-particle correlation functions are presented. The proton source exhibits a volume emission, while the deuteron source, with small outward radius, appears opaque. Both proton and deuteron sources have cross-terms R_{ol}^2 and longitudinal velocities beta consistent with zero, indicating a boost-invariant expansion. The invariant radius parameter R follows an approximate A/sqrt{m} scaling while the longitudinal and transverse radii, R_{L} and R_{T}, scale approximately as A/sqrt{m_{T}} with A ~ 3 fm GeV^{1/2} in both cases.

  2. Kaon and pion production in centrality selected minimum bias Pb+Pb collisions at 40 and 158A.GeV

    CERN Document Server

    Dinkelaker, Peter

    2009-01-01

    Results on charged kaon and negatively charged pion production and spectra for centrality selected Pb+Pb mininimum bias events at 40 and 158A GeV have been presented in this thesis. All analysis are based on data taken by the NA49 experiment at the accelerator Super Proton Synchrotron (SPS) at the European Organization for Nuclear Research (CERN) in Geneva, Switzerland. The kaon results are based on an analysis of the mean energy loss of the charged particles traversing the detector gas of the time projection chambers (TPCs). The pion results are from an analysis of all negatively charged particles h- corrected for contributions from particle decays and secondary interactions. For the dE/dx analysis of charged kaons, main TPC tracks with a total momentum between 4 and 50 GeV have been analyzed in logarithmic momentum log(p) and transverse momentum pt bins. The resulting dE/dx spectra have been fitted by the sum of 5 Gaussians, one for each main particle type (electrons, pions, kaons, pro...

  3. Variation in phytoplankton composition between two North Pacific frontal zones along 158°W during winter-spring 2008-2011

    Science.gov (United States)

    Howell, Evan A.; Bograd, Steven J.; Hoover, Aimee L.; Seki, Michael P.; Polovina, Jeffrey J.

    2017-01-01

    Data from three research cruises along the 158°W meridian through the North Pacific Subtropical Frontal Zone (STF) during spring 2008, 2009, and 2011 were used to estimate phytoplankton functional types and size classes. These groups were used to describe phytoplankton composition at the North Pacific Subtropical (STF) and Transition Zone Chlorophyll (TZCF) Fronts, which represent ecologically important large-scale features in the central North Pacific. Phytoplankton class composition was consistent at each front through time, yet significantly different between fronts. The STF contained lower integrated chlorophyll-a concentrations, with surface waters dominated by picophytoplankton and a deep chlorophyll maximum equally comprised of pico- and nanophytoplankton. The TZCF contained significantly higher concentrations of nanophytoplankton through the water column, specifically the prymnesiophyte group. Integrated chlorophyll-a concentrations at the TZCF were 30-90% higher than at the STF, with the dominant increase in the signal from the nanophytoplanktonic prymnesiophyte group. The meridional position of the STF was consistently located near 32°N through these three years, with the more spatially variable TZCF ranging from 2° to 4° further north of the STF. This variability in the frontal position of the TZCF may lead to ecological impacts though the food web. Continued in-situ and remote monitoring, specifically during El Niño and ENSO neutral phases, will provide additional ecological information to help understand mechanistic causes of phytoplankton variability in this important ecological region.

  4. J/$\\psi$ azimuthal anisotropy relative to the reaction plane in Pb-Pb collisions at 158 GeV per nucleon

    CERN Document Server

    Prino, F; Alexa, C; Arnaldi, R; Atayan, M; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Castanier, C; Castor, J; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalo, C; Comets, M P; Constantinescu, S; Cortese, P; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Fargeix, J; Force, P; Gallio, M; Gerschel, C; Giubellino, P; Golubeva, M B; Grigoryan, A A; Grigoryan, S; Guber, F F; Guichard, A; Gulkanyan, H; Idzik, M; Jouan, D; Karavicheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Mac Cormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Riccati, L; Santos, H; Saturnini, P; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, E; Villatte, L; Willis, N; Wu, T

    2009-01-01

    The J/$\\psi$ azimuthal distribution relative to the reaction plane has been measured by the NA50 experiment in Pb-Pb collisions at 158 GeV/nucleon. Various physical mechanisms related to charmonium dissociation in the medium created in the heavy ion collision are expected to introduce an anisotropy in the azimuthal distribution of the observed J/$\\psi$ mesons at SPS energies. Hence, the measurement of J/$\\psi$ elliptic anisotropy, quantified by the Fourier coefficient v$_2$ of the J/$\\psi$ azimuthal distribution relative to the reaction plane, is an important tool to constrain theoretical models aimed at explaining the anomalous J/$\\psi$ suppression observed in Pb-Pb collisions. We present the measured J/$\\psi$ yields in different bins of azimuthal angle relative to the reaction plane, as well as the resulting values of the Fourier coefficient v$_{2}$ as a function of the collision centrality and of the J/$\\psi$ transverse momentum. The reaction plane has been estimated from the azimuthal distribution of the ...

  5. Latest results from NA50 on $J/\\psi$ suppression in Pb-Pb collisions at 158 GeV/c

    CERN Document Server

    Beolè, S; Alessandro, B; Alexa, C; Arnaldi, R; Ataian, M R; Baglin, C; Baldit, A; Bedjidian, Marc; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castor, J I; Castanier, C; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constans, N; Constantinescu, S; Cortese, P; Cruz, J; De Marco, N; De Falco, A; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, G; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prado da Silva, W L; Prino, F; Puddu, G; Quintans, C; Ramos, S; Ramello, L; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Silva, S; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N

    2002-01-01

    The main goal of the NA50 experiment is to study the J/ psi suppression pattern in Pb-Pb interactions, at 158 GeV/c per nucleon at the CERN SPS. We present here the results from the 1996 and 1998 data taking periods. We used new event selection procedures, different analysis techniques and different event centrality estimators and we now confirm and extend our previous observation that the J/ psi is anomalously suppressed when going from peripheral to central Pb-Pb collisions. We observe that in peripheral collisions the J/ psi cross section per nucleon-nucleon collision agrees with the pattern inferred from a wide range of measurements with lighter systems, from p-p to S-U. When the collisions become more central a clear departure from this behavior is observed. The 1996 data show a sudden drop in the J/ psi production yield for transverse energy values above 40 GeV. The 1998 data provide a big improvement in the study of the most central region, where a second change in the pattern becomes visible. This sup...

  6. Probing the Mass and Structure of the Ring Nebula in Lyra with SOFIA/GREAT Observations of the [CII] 158 micron line

    CERN Document Server

    Sahai, R; Werner, M W; Güsten, R; Wiesemeyer, H; Sandell, G

    2012-01-01

    We have obtained new velocity-resolved spectra of the [CII] 158 micron line towards the Ring Nebula in Lyra (NGC 6720), one of the best-studied planetary nebulae, in order to probe its controversial 3-dimensional structure and to estimate the mass of circumstellar material in this object. We used the Terahertz receiver GREAT aboard the SOFIA airborne telescope to obtain the [CII] spectra at eight locations within and outside the bright optical ring of NGC 6720. Emission was detected at all positions except for the most distant position along the nebula's minor axis, and generally covers a broad velocity range, ~50 km/s (FWZI), except at a position along the major axis located just outside the optical ring, where it is significantly narrower (~25 km/s). The one narrow spectrum appears to be probing circumstellar material lying outside the main nebular shell that has not been accelerated by past fast wind episodes from the central star, and therefore most likely comes from equatorial and/or low-latitude regions...

  7. Genetic diversity of Histoplasma and Sporothrix complexes based on sequences of their ITS1-5.8S-ITS2 regions from the BOLD System.

    Science.gov (United States)

    Estrada-Bárcenas, Daniel Alfonso; Vite-Garín, Tania; Navarro-Barranco, Hortensia; de la Torre-Arciniega, Raúl; Pérez-Mejía, Amelia; Rodríguez-Arellanes, Gabriela; Ramirez, Jose Antonio; Humberto Sahaza, Jorge; Taylor, Maria Lucia; Toriello, Conchita

    2014-01-01

    High sensitivity and specificity of molecular biology techniques have proven usefulness for the detection, identification and typing of different pathogens. The ITS (Internal Transcribed Spacer) regions of the ribosomal DNA are highly conserved non-coding regions, and have been widely used in different studies including the determination of the genetic diversity of human fungal pathogens. This article wants to contribute to the understanding of the intra- and interspecific genetic diversity of isolates of the Histoplasma capsulatum and Sporothrix schenckii species complexes by an analysis of the available sequences of the ITS regions from different sequence databases. ITS1-5.8S-ITS2 sequences of each fungus, either deposited in GenBank, or from our research groups (registered in the Fungi Barcode of Life Database), were analyzed using the maximum likelihood (ML) method. ML analysis of the ITS sequences discriminated isolates from distant geographic origins and particular wild hosts, depending on the fungal species analyzed. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012).

  8. A 158 Micron [CII] Line Survey of Galaxies at z ~ 1 to 2: An Indicator of Star Formation in the Early Universe

    CERN Document Server

    Stacey, G J; Ferkinhoff, C; Nikola, T; Parshley, S C; Benford, D J; Staguhn, J G; Fiolet, N

    2010-01-01

    We have detected the 158 {\\mu}m [CII] line from 12 galaxies at z~1-2. This is the first survey of this important starformation tracer at redshifts covering the epoch of maximum star-formation in the Universe and quadruples the number of reported high z [CII] detections. The line is very luminous, between <0.024-0.65% of the far-infrared continuum luminosity of our sources, and arises from PDRs on molecular cloud surfaces. An exception is PKS 0215+015, where half of the [CII] emission could arise from XDRs near the central AGN. The L[CII] /LFIR ratio in our star-formation-dominated systems is ~8 times larger than that of our AGN-dominated systems. Therefore this ratio selects for star-formation-dominated systems. Furthermore, the L[CII]/LFIR and L[CII]/L(CO(1-0)) ratios in our starforming galaxies and nearby starburst galaxies are the same, so that luminous starforming galaxies at earlier epochs (z~1-2) appear to be scaled up versions of local starbursts entailing kilo-parsec-scale starbursts. Most of the F...

  9. Combination of deep eutectic solvent and ionic liquid to improve biocatalytic reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cell

    Science.gov (United States)

    Xu, Pei; Du, Peng-Xuan; Zong, Min-Hua; Li, Ning; Lou, Wen-Yong

    2016-05-01

    The efficient anti-Prelog asymmetric reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cells was successfully performed in a biphasic system consisting of deep eutectic solvent (DES) and water-immiscible ionic liquid (IL). Various DESs exerted different effects on the synthesis of (R)-2-octanol. Choline chloride/ethylene glycol (ChCl/EG) exhibited good biocompatibility and could moderately increase the cell membrane permeability thus leading to the better results. Adding ChCl/EG increased the optimal substrate concentration from 40 mM to 60 mM and the product e.e. kept above 99.9%. To further improve the reaction efficiency, water-immiscible ILs were introduced to the reaction system and an enhanced substrate concentration (1.5 M) was observed with C4MIM·PF6. Additionally, the cells manifested good operational stability in the reaction system. Thus, the efficient biocatalytic process with ChCl/EG and C4MIM·PF6 was promising for efficient synthesis of (R)-2-octanol.

  10. Beam-loss induced pressure rise of Large Hadron Collider collimator materials irradiated with 158 GeV/u $In^{49+}$ ions at the CERN Super Proton Synchrotron

    CERN Document Server

    Mahner, Edgar; Hansen, Jan; Page, Eric; Vincke, H

    2004-01-01

    During heavy ion operation, large pressure rises, up to a few orders of magnitude, were observed at CERN, GSI, and BNL. The dynamic pressure rises were triggered by lost beam ions that impacted onto the vacuum chamber walls and desorbed about 10/sup 4/ to 10/sup 7/ molecules per ion. The deterioration of the dynamic vacuum conditions can enhance charge-exchange beam losses and can lead to beam instabilities or even to beam abortion triggered by vacuum interlocks. Consequently, a dedicated measurement of heavy-ion induced molecular desorption in the GeV/u energy range is important for Large Hadron Collider (LHC) ion operation. In 2003, a desorption experiment was installed at the super proton synchrotron to measure the beam-loss induced pressure rise of potential LHC collimator materials. Samples of bare graphite, sputter coated (Cu, TiZrV) graphite, and 316 LN (low carbon with nitrogen) stainless steel were irradiated under grazing angle with 158 GeV/u indium ions. After a description of the new experimental ...

  11. Structures of incommensurate and commensurate composite crystals NaxCuO2 (x=1.58, 1.6, 1.62).

    Science.gov (United States)

    van Smaalen, Sander; Dinnebier, Robert; Sofin, Mikhail; Jansen, Martin

    2007-02-01

    NaxCuO2 (x approximately 1.6) has been synthesized for different compositions x, resulting in both commensurate and incommensurate composite crystals. The crystal structures are reported for two incommensurate compounds (x=1.58 and 1.62) determined by Rietveld refinements against X-ray powder diffraction data. The incommensurate compounds and commensurate Na8Cu5O10 (x=1.6) are found to possess similar structures, with valence fluctuations of Cu2+/Cu3+ as the origin of the modulations of the CuO2 subsystems; the displacive modulations of Na being defined by the closest Na-O contacts between the subsystems. A comparison of the structure models obtained from single-crystal X-ray diffraction, synchrotron-radiation X-ray powder diffraction and X-ray powder diffraction with Cu Kalpha1 radiation indicates that single-crystal X-ray diffraction is by far the most accurate method, while powder diffraction with radiation from an X-ray tube provides the least accurate structure model.

  12. Structures of Incommensurate and Commensurate Composite Crystals NaxCuO2(x=1.58, 1.6, 1.62)

    Energy Technology Data Exchange (ETDEWEB)

    van Smaalen,S.; Dinnebier, R.; Sofin, M.; Jansen, M.

    2007-01-01

    NaxCuO2 (x {approx_equal} 1.6) has been synthesized for different compositions x, resulting in both commensurate and incommensurate composite crystals. The crystal structures are reported for two incommensurate compounds (x = 1.58 and 1.62) determined by Rietveld refinements against X-ray powder diffraction data. The incommensurate compounds and commensurate Na{sub 8}Cu{sub 5}O{sub 10} (x = 1.6) are found to possess similar structures, with valence fluctuations of Cu{sup 2+}/Cu{sup 3+} as the origin of the modulations of the CuO{sub 2} subsystems; the displacive modulations of Na being defined by the closest Na-O contacts between the subsystems. A comparison of the structure models obtained from single-crystal X-ray diffraction, synchrotron-radiation X-ray powder diffraction and X-ray powder diffraction with Cu K{sub 1} radiation indicates that single-crystal X-ray diffraction is by far the most accurate method, while powder diffraction with radiation from an X-ray tube provides the least accurate structure model.

  13. ALMA [C II] 158 μm Detection of a Redshift 7 Lensed Galaxy behind RXJ1347.1‑1145

    Science.gov (United States)

    Bradač, Maruša; Garcia-Appadoo, Diego; Huang, Kuang-Han; Vallini, Livia; Quinn Finney, Emily; Hoag, Austin; Lemaux, Brian C.; Borello Schmidt, Kasper; Treu, Tommaso; Carilli, Chris; Dijkstra, Mark; Ferrara, Andrea; Fontana, Adriano; Jones, Tucker; Ryan, Russell; Wagg, Jeff; Gonzalez, Anthony H.

    2017-02-01

    We present the results of ALMA spectroscopic follow-up of a z = 6.766 Lyα emitting galaxy behind the cluster RX J1347.1‑1145. We report the detection of [C ii] 158 μm line fully consistent with the Lyα redshift and with the peak of the optical emission. Given the magnification of μ = 5.0 ± 0.3, the intrinsic (corrected for lensing) luminosity of the [C ii] line is L [C ii] = {1.4}-0.3+0.2× {10}7 {L}ȯ , roughly ∼5 times fainter than other detections of z ∼ 7 galaxies. The result indicates that low L [C ii] in z ∼ 7 galaxies compared to the local counterparts might be caused by their low metallicities and/or feedback. The small velocity offset ({{Δ }}v={20}-40+140 {km} {{{s}}}-1) between the Lyα and [C ii] line is unusual, and may be indicative of ionizing photons escaping. These observations are based on the following ALMA data: ADS/JAO.ALMA#2015.1.00091.S. They are also associated with programs Spitzer #90009, 60034, 00083, 50610, 03550, 40593, and HST # GO10492, GO11591, GO12104, and GO13459. Furthermore based on multi-year KECK programs.

  14. The VMC Survey. XXII. Hierarchical Star Formation in the 30 Doradus-N158–N159–N160 Star-forming Complex

    Science.gov (United States)

    Sun, Ning-Chen; de Grijs, Richard; Subramanian, Smitha; Cioni, Maria-Rosa L.; Rubele, Stefano; Bekki, Kenji; Ivanov, Valentin D.; Piatti, Andrés E.; Ripepi, Vincenzo

    2017-02-01

    We study the hierarchical stellar structures in a ∼1.5 deg2 area covering the 30 Doradus-N158–N159–N160 star-forming complex with the VISTA Survey of Magellanic Clouds. Based on the young upper main-sequence stars, we find that the surface densities cover a wide range of values, from log({{Σ }}\\cdot pc2) ≲ ‑2.0 to log({{Σ }}\\cdot pc2) ≳ 0.0. Their distributions are highly non-uniform, showing groups that frequently have subgroups inside. The sizes of the stellar groups do not exhibit characteristic values, and range continuously from several parsecs to more than 100 pc the cumulative size distribution can be well described by a single power law, with the power-law index indicating a projected fractal dimension D2 = 1.6 ± 0.3. We suggest that the phenomena revealed here support a scenario of hierarchical star formation. Comparisons with other star-forming regions and galaxies are also discussed.

  15. Combination of deep eutectic solvent and ionic liquid to improve biocatalytic reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cell.

    Science.gov (United States)

    Xu, Pei; Du, Peng-Xuan; Zong, Min-Hua; Li, Ning; Lou, Wen-Yong

    2016-01-01

    The efficient anti-Prelog asymmetric reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cells was successfully performed in a biphasic system consisting of deep eutectic solvent (DES) and water-immiscible ionic liquid (IL). Various DESs exerted different effects on the synthesis of (R)-2-octanol. Choline chloride/ethylene glycol (ChCl/EG) exhibited good biocompatibility and could moderately increase the cell membrane permeability thus leading to the better results. Adding ChCl/EG increased the optimal substrate concentration from 40 mM to 60 mM and the product e.e. kept above 99.9%. To further improve the reaction efficiency, water-immiscible ILs were introduced to the reaction system and an enhanced substrate concentration (1.5 M) was observed with C4MIM·PF6. Additionally, the cells manifested good operational stability in the reaction system. Thus, the efficient biocatalytic process with ChCl/EG and C4MIM·PF6 was promising for efficient synthesis of (R)-2-octanol.

  16. The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds.

    Science.gov (United States)

    Harris, Sarah E; Wright, Alan F; Hayward, Caroline; Starr, John M; Whalley, Lawrence J; Deary, Ian J

    2005-09-02

    A polymorphism (Val 158 Met) in the gene for catechol-O-methyl transferase (COMT) was previously associated with differences in cognitive ability and personality. Here we examine associations between this polymorphism and cognitive ability, cognitive aging, personality and mood in 460 relatively healthy people born in 1921. All had cognitive ability measured at age 11 in the Scottish Mental Survey of 1932, and again at age 79. COMT genotype was not associated with childhood IQ. At age 79, COMT genotype was significantly related to differences in verbal declarative memory (scores on the Logical Memory test; p=0.028) and to scores on the personality trait of intellect/imagination (p=0.023), adjusted for sex and childhood IQ. In both cases the Val/Met heterozygotes had higher scores than both homozygous groups. There were trends toward the heterozygotes having higher scores on the personality traits of agreeableness and conscientiousness. The effect of COMT genotype on Logical Memory scores was independent of the effect of APOE genotype, and similar in effect size. Therefore, COMT genotype may contribute to differences in normal cognitive aging and to differences in some of the major personality traits in old age.

  17. Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children.

    Science.gov (United States)

    Sugiura, Lisa; Toyota, Tomoko; Matsuba-Kurita, Hiroko; Iwayama, Yoshimi; Mazuka, Reiko; Yoshikawa, Takeo; Hagiwara, Hiroko

    2016-11-30

    The genetic basis controlling language development remains elusive. Previous studies of the catechol-O-methyltransferase (COMT) Val(158)Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine. However, COMT may further influence posterior cortical regions implicated in language perception. We investigated whether COMT influences language ability and cortical language processing involving the posterior language regions in 246 children aged 6-10 years. We assessed language ability using a language test and cortical responses recorded during language processing using a word repetition task and functional near-infrared spectroscopy. The COMT genotype had significant effects on language performance and processing. Importantly, Met carriers outperformed Val homozygotes in language ability during the early elementary school years (6-8 years), whereas Val homozygotes exhibited significant language development during the later elementary school years. Both genotype groups exhibited equal language performance at approximately 10 years of age. Val homozygotes exhibited significantly less cortical activation compared with Met carriers during word processing, particularly at older ages. These findings regarding dopamine transmission efficacy may be explained by a hypothetical inverted U-shaped curve. Our findings indicate that the effects of the COMT genotype on language ability and cortical language processing may change in a narrow age window of 6-10 years.

  18. Inclusive production of protons, anti-protons, neutrons, deuterons and tritons in p+C collisions at 158 GeV/c beam momentum

    Energy Technology Data Exchange (ETDEWEB)

    Baatar, B.; Kolesnikov, V.; Malakhov, A.; Melkumov, G. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Barr, G.; Tinti, G. [Oxford University, Oxford (United Kingdom); Bartke, J.; Kowalski, M.; Rybicki, A. [Polish Academy of Sciences, H. Niewodniczanski Institute of Nuclear Physics, Cracow (Poland); Betev, L.; Fischer, H.G.; Karev, A.; Wenig, S. [CERN, Geneva (Switzerland); Chvala, O.; Dolejsi, J. [Charles University, Faculty of Mathematics and Physics, Institute of Particle and Nuclear Physics, Prague (Czech Republic); Eckardt, V.; Schmitz, N.; Seyboth, P. [Max-Planck-Institut fuer Physik, Munich (Germany); Fodor, Z.; Vesztergombi, G. [KFKI Research Institute for Particle and Nuclear Physics, Budapest (Hungary); Makariev, M. [Bulgarian Academy of Sciences, Institute for Nuclear Research and Nuclear Energy, Sofia (Bulgaria); Mateev, M. [Sofia University St. Kliment Ohridski, Atomic Physics Department, Sofia (Bulgaria); Stock, R. [Fachbereich Physik der Universitaet, Frankfurt (Germany); Varga, D. [Eoetvoes Lorand University, Budapest (Hungary)

    2013-04-15

    The production of protons, anti-protons, neutrons, deuterons and tritons in minimum bias p+C interactions is studied using a sample of 385 734 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The data cover a phase space area ranging from 0 to 1.9 GeV/c in transverse momentum and in Feynman x from -0.8 to 0.95 for protons, from -0.2 to 0.3 for anti-protons and from 0.1 to 0.95 for neutrons. Existing data in the far backward hemisphere are used to extend the coverage for protons and light nuclear fragments into the region of intra-nuclear cascading. The use of corresponding data sets obtained in hadron-proton collisions with the same detector allows for the detailed analysis and model-independent separation of the three principle components of hadronization in p+C interactions, namely projectile fragmentation, target fragmentation of participant nucleons and intra-nuclear cascading. (orig.)

  19. Strangelet search and particle production studies in Pb-Pb collisions at 158·A GeV/c with the H6 beamline spectrometer at CERN

    CERN Document Server

    Lindén, Tomas

    The charged particle beamline simulation program DECAY TURTLE (Trace Unlimited Rays Through Lumped Elements) has been modified to enable simulation of dipole magnet steering effects and simulation of hadronic interactions. These modifications together with the implementation of the measured misalignments of the magnetic elements of the H6 beamline at the CERN North Area and implementation of more accurate magnet apertures have been shown to allow a realistic simulation to be made of the complex 524 m long H6 beamline spectrometer used by NA52. The acceptance of the H6 beamline spectrometer has been computed using this modified version of DECAY TURTLE. Using these results better determined invariant differential production cross sections have been computed from the NA52 1994-1995 data, with improved error estimates. New limits for strangelet production in lead-lead collisions at 158.A GeV/c have been computed from the NA52 measurements from 1994-1995. The methods and results presented in this work can be appli...

  20. The thermal dust emission in the N158-N159-N160 (LMC) star forming complex mapped by Spitzer, Herschel and LABOCA

    CERN Document Server

    Galametz, M; Galliano, F; Madden, S C; Albrecht, M; Bot, C; Cormier, D; Engelbracht, C; Fukui, Y; Israel, F P; Kawamura, A; Lebouteiller, V; Li, A; Meixner, M; Misselt, K; Montiel, E; Okumura, K; Panuzzo, P; Duval, J Roman-; Rubio, M; Sauvage, M; Seale, J P; Sewilo, M; van Loon, J Th

    2013-01-01

    We present a study of the infrared/submm emission of the LMC star forming complex N158-N159-N160. Combining observations from the Spitzer Space Telescope (3.6-70um), the Herschel Space Observatory (100-500um) and LABOCA (870um) allows us to work at the best angular resolution available now for an extragalactic source. We observe a remarkably good correlation between SPIRE and LABOCA emission and resolve the low surface brightnesses emission. We use the Spitzer and Herschel data to perform a resolved Spectral Energy Distribution (SED) modelling of the complex. Using MBB, we derive a global emissivity index beta_c of 1.47. If beta cold is fixed to 1.5, we find an average temperature of 27K. We also apply the Galliano et al. (2011) modelling technique (and amorphous carbon to model carbon dust) to derive maps of the star formation rate, the mean starlight intensity, the fraction of PAHs or the dust mass surface density of the region. We observe that the PAH fraction strongly decreases in the HII regions. This de...

  1. Measurement of negatively charged pion spectra in inelastic p+p interactions at p{sub lab} = 20, 31, 40, 80 and 158 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Abgrall, N.; Blondel, A.; Bravar, A.; Debieux, S.; Haesler, A.; Korzenev, A.; Murphy, S.; Ravonel, M. [University of Geneva, Geneva (Switzerland); Aduszkiewicz, A.; Dominik, W.; Kielczewska, D.; Kirejczyk, M.; Matulewicz, T.; Posiadala, M.; Skrzypczak, E. [University of Warsaw, Faculty of Physics, Warsaw (Poland); Ali, Y.; Brzychczyk, J.; Majka, Z.; Marcinek, A.; Planeta, R.; Staszel, P.; Wyszynski, O. [Jagiellonian University, Cracow (Poland); Anticic, T.; Kadija, K.; Susa, T. [Rudjer Boskovic Institute, Zagreb (Croatia); Antoniou, N.; Christakoglou, P.; Davis, N.; Diakonos, F.; Kapoyannis, A.; Panagiotou, A.D.; Vassiliou, M. [University of Athens, Athens (Greece); Baatar, B.; Bunyatov, S.A.; Kolesnikov, V.I.; Krasnoperov, A.; Lyubushkin, V.V.; Malakhov, A.I.; Melkumov, G.L.; Tereshchenko, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bay, F.; Luise, S.Di; Rubbia, A.; Sgalaberna, D. [ETH, Zurich (Switzerland); Blumer, J.; Dembinski, H.; Engel, R.; Mathes, H.J.; Roth, M.; Szuba, M.; Ulrich, R.; Unger, M. [Karlsruhe Institute of Technology, Karlsruhe (Germany); Bogomilov, M.; Kolev, D.; Tsenov, R. [University of Sofia, Faculty of Physics, Sofia (Bulgaria); Busygina, O.; Golubeva, M.; Guber, F.; Ivashkin, A.; Kurepin, A.; Marin, V.; Petukhov, O.; Sadovsky, A. [Institute for Nuclear Research, Moscow (Russian Federation); Czopowicz, T.; Dynowski, K.; Grebieszkow, K.; Maksiak, B.; Peryt, W.; Pluta, J.; Slodkowski, M. [Warsaw University of Technology, Warsaw (Poland); Drozhzhova, T.; Feofilov, G.A.; Igolkin, S.; Kondratiev, V.P.; Vechernin, V.V.; Vinogradov, L. [St. Petersburg State University, St. Petersburg (Russian Federation); Dumarchez, J.; Robert, A.; Zambelli, L. [LPNHE, University of Paris VI and VII, Paris (France); Ereditato, A.; Hierholzer, M.; Nirkko, M.; Pistillo, C.; Redij, A. [University of Bern, Bern (Switzerland); Fodor, Z.; Fulop, A.; Kiss, T.; Laszlo, A.; Marton, K.; Palla, G.; Sipos, R.; Tolyhi, T.; Vesztergombi, G. [KFKI Research Institute for Particle and Nuclear Physics, Budapest (Hungary); Gazdzicki, M. [Jan Kochanowski University in Kielce, Kielce (Poland); University of Frankfurt, Frankfurt (Germany); Grzeszczuk, A.; Kaptur, E.; Kisiel, J.; Kowalski, S.; Larsen, D.; Pulawski, S.; Schmidt, K.; Wilczek, A.; Zipper, W. [University of Silesia, Katowice (Poland); Hasegawa, T.; Kobayashi, T.; Nakadaira, T.; Nishikawa, K.; Sakashita, K.; Sekiguchi, T.; Shibata, M.; Tada, M. [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki (Japan); Idczak, R.; Kovesarki, P.; Turko, L. [University of Wroclaw, Wroclaw (Poland); Jokovic, D.; Manic, D.; Puzovic, J.; Savic, M. [University of Belgrade, Belgrade (Serbia); Kleinfelder, S. [University of California, Irvine (United States); Mackowiak-Pawlowska, M.; Renfordt, R.; Rustamov, A.; Stroebele, H. [University of Frankfurt, Frankfurt (Germany); Matveev, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Institute for Nuclear Research, Moscow (Russian Federation); Mrowczynski, S.; Rybczynski, M.; Seyboth, P.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University in Kielce, Kielce (Poland); Palczewski, T.; Rondio, E.; Stepaniak, J. [National Centre for Nuclear Research, Warsaw (Poland); Paul, T.; Veberic, D. [University Nova Gorica, Laboratory of Astroparticle Physics, Nova Gorica (Slovenia); Popov, B.A. [Joint Institute for Nuclear Research, Dubna (Russian Federation); LPNHE, University of Paris VI and VII, Paris (France); Rauch, W. [Fachhochschule Frankfurt, Frankfurt (Germany); Roehrich, D. [University of Bergen, Bergen (Norway); Collaboration: NA61/SHINE Collaboration

    2014-03-15

    We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/c (√(s) = 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter. They are required for interpretation of results on nucleus-nucleus and proton-nucleus collisions. (orig.)

  2. Measurement of negatively charged pion spectra in inelastic p+p interactions at 20, 31, 40, 80 and 158 GeV/c

    Science.gov (United States)

    Abgrall, N.; Aduszkiewicz, A.; Ali, Y.; Anticic, T.; Antoniou, N.; Baatar, B.; Bay, F.; Blondel, A.; Blumer, J.; Bogomilov, M.; Bravar, A.; Brzychczyk, J.; Bunyatov, S. A.; Busygina, O.; Christakoglou, P.; Czopowicz, T.; Davis, N.; Debieux, S.; Dembinski, H.; Diakonos, F.; Luise, S. Di; Dominik, W.; Drozhzhova, T.; Dumarchez, J.; Dynowski, K.; Engel, R.; Ereditato, A.; Feofilov, G. A.; Fodor, Z.; Fulop, A.; Gaździcki, M.; Golubeva, M.; Grebieszkow, K.; Grzeszczuk, A.; Guber, F.; Haesler, A.; Hasegawa, T.; Hierholzer, M.; Idczak, R.; Igolkin, S.; Ivashkin, A.; Joković, D.; Kadija, K.; Kapoyannis, A.; Kaptur, E.; Kiełczewska, D.; Kirejczyk, M.; Kisiel, J.; Kiss, T.; Kleinfelder, S.; Kobayashi, T.; Kolesnikov, V. I.; Kolev, D.; Kondratiev, V. P.; Korzenev, A.; Kovesarki, P.; Kowalski, S.; Krasnoperov, A.; Kurepin, A.; Larsen, D.; László, A.; Lyubushkin, V. V.; Maćkowiak-Pawłowska, M.; Majka, Z.; Maksiak, B.; Malakhov, A. I.; Manić, D.; Marcinek, A.; Marin, V.; Marton, K.; Mathes, H.-J.; Matulewicz, T.; Matveev, V.; Melkumov, G. L.; Mrówczyński, St.; Murphy, S.; Nakadaira, T.; Nirkko, M.; Nishikawa, K.; Palczewski, T.; Palla, G.; Panagiotou, A. D.; Paul, T.; Pistillo, C.; Peryt, W.; Petukhov, O.; Płaneta, R.; Pluta, J.; Popov, B. A.; Posiadała, M.; Puławski, S.; Puzović, J.; Rauch, W.; Ravonel, M.; Redij, A.; Renfordt, R.; Robert, A.; Röhrich, D.; Rondio, E.; Roth, M.; Rubbia, A.; Rustamov, A.; Rybczyński, M.; Sadovsky, A.; Sakashita, K.; Savić, M.; Schmidt, K.; Sekiguchi, T.; Seyboth, P.; Sgalaberna, D.; Shibata, M.; Sipos, R.; Skrzypczak, E.; Słodkowski, M.; Staszel, P.; Stefanek, G.; Stepaniak, J.; Ströbele, H.; Šuša, T.; Szuba, M.; Tada, M.; Tereshchenko, V.; Tolyhi, T.; Tsenov, R.; Turko, L.; Ulrich, R.; Unger, M.; Vassiliou, M.; Veberič, D.; Vechernin, V. V.; Vesztergombi, G.; Vinogradov, L.; Wilczek, A.; Włodarczyk, Z.; Wojtaszek-Szwarc, A.; Wyszyński, O.; Zambelli, L.; Zipper, W.

    2014-03-01

    We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/ c ( 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter. They are required for interpretation of results on nucleus-nucleus and proton-nucleus collisions.

  3. A SNP Harvester Analysis to Better Detect SNPs of CCDC158 Gene That Are Associated with Carcass Quality Traits in Hanwoo.

    Science.gov (United States)

    Lee, Jea-Young; Lee, Jong-Hyeong; Yeo, Jung-Sou; Kim, Jong-Joo

    2013-06-01

    The purpose of this study was to investigate interaction effects of genes using a Harvester method. A sample of Korean cattle, Hanwoo (n = 476) was chosen from the National Livestock Research Institute of Korea that were sired by 50 Korean proven bulls. The steers were born between the spring of 1998 and the autumn of 2002 and reared under a progeny-testing program at the Daekwanryeong and Namwon branches of NLRI. The steers were slaughtered at approximately 24 months of age and carcass quality traits were measured. A SNP Harvester method was applied with a support vector machine (SVM) to detect significant SNPs in the CCDC158 gene and interaction effects between the SNPs that were associated with average daily gains, cold carcass weight, longissimus dorsi muscle area, and marbling scores. The statistical significance of the major SNP combinations was evaluated with x (2)-statistics. The genotype combinations of three SNPs, g.34425+102 A>T(AA), g.4102636T>G(GT), and g.11614+19G>T(GG) had a greater effect than the rest of SNP combinations, e.g. 0.82 vs. 0.75 kg, 343 vs. 314 kg, 80.4 vs 74.7 cm(2), and 7.35 vs. 5.01, for the four respective traits (pHarvester method is a good option when multiple SNPs and interaction effects are tested. The significant SNPs could be applied to improve meat quality of Hanwoo via marker-assisted selection.

  4. Beam-Loss Induced Pressure Rise of LHC Collimator Materials Irradiated with 158 GeV/u $In^{49+}$ Ions at the CERN SPS

    CERN Document Server

    Mahner, Edgar; Hansen, Jan; Page, Eric; Vincke, Helmut H

    2004-01-01

    During heavy ion operation, large pressure rises, up to a few orders of magnitude, were observed at CERN, GSI, and BNL. The dynamic pressure rises were triggered by lost beam ions that impacted onto the vacuum chamber walls and desorbed about 1044 to 107 molecules per ion. The deterioration of the dynamic vacuum conditions can enhance charge-exchange beam losses and can lead to beam instabilities or even to beam abortion triggered by vacuum interlocks. Consequently, a dedicated measure-ment of heavy-ion induced molecular desorption in the GeV/u energy range is important for LHC ion operation. In 2003, a desorption experiment was installed at the SPS to measure the beam-loss induced pressure rise of potential LHC collimator materials. Samples of bare graphite, sputter coated (Cu, TiZrV) graphite, and 316 LN stainless steel, were irradiated under grazing angle with 158 GeV/u indium ions. After a description of the new experimental set-up, the results of the pressure rise measurements are presented, and the deri...

  5. Beam-loss induced pressure rise of Large Hadron Collider collimator materials irradiated with 158 GeV/u In49+ ions at the CERN Super Proton Synchrotron

    Science.gov (United States)

    Mahner, E.; Efthymiopoulos, I.; Hansen, J.; Page, E.; Vincke, H.

    2004-10-01

    During heavy ion operation, large pressure rises, up to a few orders of magnitude, were observed at CERN, GSI, and BNL. The dynamic pressure rises were triggered by lost beam ions that impacted onto the vacuum chamber walls and desorbed about 104 to 107 molecules per ion. The deterioration of the dynamic vacuum conditions can enhance charge-exchange beam losses and can lead to beam instabilities or even to beam abortion triggered by vacuum interlocks. Consequently, a dedicated measurement of heavy-ion induced molecular desorption in the GeV/u energy range is important for Large Hadron Collider (LHC) ion operation. In 2003, a desorption experiment was installed at the Super Proton Synchrotron to measure the beam-loss induced pressure rise of potential LHC collimator materials. Samples of bare graphite, sputter coated (Cu, TiZrV) graphite, and 316LN (low carbon with nitrogen) stainless steel were irradiated under grazing angle with 158 GeV/u indium ions. After a description of the new experimental setup, the results of the pressure rise measurements are presented, and the derived desorption yields are compared with data from other experiments.

  6. Measurement of negatively charged pion spectra in inelastic p+p interactions at $p_{lab}$ = 20, 31, 40, 80 and 158 GeV/c

    CERN Document Server

    Abgrall, N; Ali, Y; Anticic, T; Antoniou, N; Baatar, B; Bay, F; Blondel, A; Blumer, J; Bogomilov, M; Bravar, A; Brzychczyk, J; Bunyatov, S A; Busygina, O; Christakoglou, P; Czopowicz, T; Davis, N; Debieux, S; Dembinski, H; Diakonos, F; Di Luise, S; Dominik, W; Drozhzhova, T; Dumarchez, J; Dynowski, K; Engel, R; Ereditato, A; Feofilov, G A; Fodor, Z; Fulop, A; Gazdzicki, M; Golubeva, M; Grebieszkow, K; Grzeszczuk, A; Guber, F; Haesler, A; Hasegawa, T; Hierholzer, M; Idczak, R; Igolkin, S; Ivashkin, A; Jokovic, D; Kadija, K; Kapoyannis, A; Katrynska, N; Kaptur, E; Kielczewska, D; Kirejczyk, M; Kisiel, J; Kiss, T; Kleinfelder, S; Kobayashi, T; Kolesnikov, V I; Kolev, D; Kondratiev, V P; Korzenev, A; Kovesarki, P; Kowalski, S; Krasnoperov, A; Kurepin, A; Larsen, D; Laszlo, A; Lyubushkin, V V; Mackowiak-Pawlowska, M; Majka, Z; Maksiak, B; Malakhov, A I; Manic, D; Marcinek, A; Marin, V; Marton, K; Mathes, H J; Matulewicz, T; Matveev, V; Melkumov, G.L; Mrowczynski, St; Murphy, S; Nakadaira, T; Nirkko, M; Nishikawa, K; Palczewski, T; Palla, G; Panagiotou, A D; Paul, T; Pistillo, C; Peryt, W; Petukhov, O; Planeta, R; Pluta, J; Popov, B A; Posiadala, M; Pulawski, S; Puzovic, J; Rauch, W; Ravonel, M; Redij, A; Renfordt, R; Robert, A; Rohrich, D; Rondio, E; Roth, M; Rubbia, A; Rustamov, A; Rybczynski, M; Sadovsky, A; Sakashita, K; Savic, M; Schmidt, K; Sekiguchi, T; Seyboth, P; Sgalaberna, D; Shibata, M; Sipos, R; Skrzypczak, E; Slodkowski, M; Staszel, P; Stefanek, G; Stepaniak, J; Strobele, H; Susa, T; Szuba, M; Tada, M; Tereshchenko, V; Tolyhi, T; Tsenov, R; Turko, L; Ulrich, R; Unger, M; Vassiliou, M; Veberic, D; Vechernin, V V; Vesztergombi, G; Vinogradov, L; Wilczek, A; Wlodarczyk, Z; Wojtaszek-Szwarc, A; Wyszynski, O; Zambelli, L; Zipper, W

    2014-01-01

    We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158GeV/c ($\\sqrt{s}$ = 6.3, 7.7, 8.8, 12.3 and 17.3GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly inter...

  7. Phylogenetic relationships within the genus Aspidisca (Protozoa, Ciliophora, Euplotida) revealed by ITS1-5.8S-ITS2 region sequences

    Science.gov (United States)

    Huang, Jie; Yi, Zhenzhen; Miao, Miao; Al-Rasheid, Khaled A. S.; Song, Weibo

    2011-03-01

    The internal transcribed spacer regions (ITS1 and ITS2) and 5.8S rRNA genes were sequenced in six populations of four Aspidisca species, namely A. leptaspis, A. orthopogon, A. magna and A. aculeata. Phylogenetic trees were constructed by means of Bayesian inference (BI), Maximum Parsimony (MP), Neighbor-Joining (NJ), and Maximum Likelihood (ML) to assess the inter- and intra-species relationships within the genus Aspidisca. All trees show similar topologies with stable supports and indicate that: (1) four well known groups, i.e., Oligotrichia, Stichotrichia, Choreotrichia and Hypotrichia, are distinctly outlined within the class Spirotrichea, and all are monophyletic other than Hypotrichia; (2) members of Aspidisca can be distinguished well, based on the ITS1-5.8S-ITS2 region sequences, and A. leptaspis and A. magna shared a closer relationship than other species; (3) Aspidisca and Euplotes branch early in the subclass Hypotrichia. To compare the phylogenetic relationships based on different genes, SSU rRNA trees were also constructed with nearly the same species inclusion, which revealed different topologies of inter-species, inter-genera and inter-subclasses.

  8. Observations of [C II] 158 micron Line and Far-infrared Continuum Emission toward the High-latitude Molecular Clouds in Ursa Major

    CERN Document Server

    Matsuhara, H; Yonekura, Y; Fukui, Y; Kawada, M K; Bock, J J; Matsuhara, Hideo; Tanaka, Masahiro; Yonekura, Yoshinori; Fukui, Yasuo; Kawada, Mitsunobu; Bock, James. J.

    1997-01-01

    We report the results of a rocket-borne observation of [C II] 158\\micron line and far-infrared continuum emission at 152.5\\micron toward the high latitude molecular clouds in Ursa Major. We also present the results of a follow-up observation of the millimeter ^{12}CO J=1-0 line over a selected region observed by the rocket-borne experiment. We have discovered three small CO cloudlets from the follow-up ^{12}CO observations. We show that these molecular cloudlets, as well as the MBM clouds(MBM 27/28/29/30), are not gravitationally bound. Magnetic pressure and turbulent pressure dominate the dynamic balance of the clouds. After removing the HI-correlated and background contributions, we find that the [C II] emission peak is displaced from the 152.5\\micron and CO peaks, while the 152.5\\micron continuum emission is spatially correlated with the CO emission. We interpret this behavior by attributing the origin of [C II] emission to the photodissociation regions around the molecular clouds illuminated by the local ...

  9. 新疆158名育龄期妇女乳腺自检与临检认知情况分析%Analysis situation of breast self-examination and clinical inspection cognition at reproductive age women in Xinjiang with 158 case

    Institute of Scientific and Technical Information of China (English)

    辛丽萍; 杨舒旖; 王淑霞

    2015-01-01

    Objective To investigate the influence factors and situation of breast self-examination and clinical in-spection cognition of women in childbearing age,and to provide reference for health education.Methods Randomly selected 158 case in First Affiliated Hospital of Xinjiang Medical University from 2012 January to 2013 December in women of childbearing age as the object of study,using the questionnaire survey,analyzed by SPSS 17.0.Results 158 cases of women of childbearing age self-cognitive scores and clinical cognitive score were 5.09 ±1.00 and 7.15±1.31,the difference was statistically significant (P <0.05);different nationality,marital status, educational level of the women in the self-inspection and clinical cognition score were different (P <0.05);age and self-checking,clinical cognitive score correlation coefficientr = 0.324,r = 0.34 (P <0.05);self-cognition level influence factors including age,race,marital status,educational level (P <0.05);clinical cognitive influence factor including age,ethnic,cultural level (P <0.05).Conclusion For the low age,the Han nationality,low cul-tural level,divorced,widowed,single women should strengthen health education.%目的:了解新疆育龄期妇女乳腺自检与临检认知水平及其影响因素,为育龄期妇女健康教育提供参考资料。方法随机抽取2012年1月-2013年12月在新疆医科大学第一附属医院健康管理中心健康体检部参加体检和咨询的育龄期妇女158名作为研究对象,进行问卷调查。结果158名育龄期妇女自检认知得分为(5.09±1.00)分,临检得分为(7.15±1.31)分,差异有统计学意义(P <0.05);不同民族、婚姻状况、文化水平的育龄期妇女的自检、临检认知水平差异有统计学意义(P <0.05);年龄与自检、临检认知得分相关系数分别为 r =0.324、r =0.340(P <0.05);自检认知水平的影响因素包括年龄、民族、文化水平,

  10. Comparison of cytopathological changes of plant hosts infected with two Broad bean wilt virus 2 isolates PV131 and P158%蚕豆萎蔫病毒2号分离物PV131和P158侵染寄主植物的细胞病理比较观察

    Institute of Scientific and Technical Information of China (English)

    刘成科; 李燕宏; 王卫兵; 洪健; 周雪平

    2009-01-01

    透射电镜观察比较了蚕豆萎蔫病毒2号(BBWV-2)分离物PV131和P158侵染昆诺藜(Chenopodium quinoa)和蚕豆(Viciafaba)的细胞超微结构变化.结果显示:受PV131分离物侵染的昆诺藜叶肉细胞质中膜结构大茸增生,形成有膜状结构、大小泡囊及电子致密物质的特殊膜增生区;病毒粒子散布在细胞质中,形成大块结晶体和管状结构,该管状结构直径约75 nm,横切面由9个病毒粒子组成;受PV131侵染的蚕豆叶肉细胞中也形成膜增生区和管状结构,未见病毒结晶体.受P158分离物侵染的昆诺藜和蚕豆叶肉细胞病变情况与PV131分离物相似,形成膜增生区和相同的管状结构,在蚕豆叶肉细胞中也未观察到病毒结晶体.上述结果表明:2个BBWV-2分离物虽然在不同寄主植物上引起的细胞病变程度有差异,但其细胞病理学特征是由病毒基因结构所决定,与寄主的种类无关.

  11. 显露喉返神经的甲状腺手术临床研究附158例体会

    Institute of Scientific and Technical Information of China (English)

    刘珊; 邓瑞华

    2012-01-01

      目的:探讨甲状腺手术中显露喉返神经的方法及其意义.方法:回顾性分析2008年4月至2012年1月本院收治的甲状腺手术患者278例的临床资料,其中120例术中未显露喉返神经(为未显露组),158例术中常规显露喉返神经(为显露组).比较2组术后喉返神经损伤情况.结果:未显露组8例患者(6.67%)出现神经损伤,其中4例为暂时性的损伤,l例出现呼吸困难,术后3个月内均恢复,3例为永久性损伤.显露组3例患者(1.90%)出现神经损伤,均为暂时性的损伤,对症治疗后2-6周内均恢复.未显露组喉返神经损伤发生率明显高于显露组(P<0.05),有统计学意义.结论:甲状腺手术中合理的显露喉返神经可明显降低喉返神经的损伤率%  Objective:to investigate the methods and significance of the exposure of recurrent laryngeal nerve in thyroid surgery.Methods:From April 2008 to January 2012,the clinical data of 278 cases for the patients with thyroid surgery were retrospectively analyzed.Among them,120 cases were without exposure of recurrent laryngeal nerve in the operation(non exposure group of the RLN),the other 158 cases treated with operation of exposure of the recurrent laryngeal nerve routinely(nerve exposure group),and the results were compared.Results:there were 8 cases of the non exposure group with injury of the nerve(the rate was 6.67%),among them,4 cases were the temporary injury,1 case was dyspnea,and all would recovery in the 3 months of the operation,the other 3 cases was permanent injury.For the exposure group,3 cases suffered nerve injury(the rate was 1.08%), and were temporary injury,all of them recovered in 2-6 weeks after symptomatic treatment.These data showed that the injury of the recurrent laryngeal nerve for the non exposure group was obviously higher than that of the exposure group and the difference was significant(p<0.05).Conclusion:the injury of the recurrent laryngeal nerve was significantly

  12. Effect of catechol-O-methyltransferase-val158met-polymorphism on the automatization of motor skills - a post hoc view on an experimental data.

    Science.gov (United States)

    Krause, Daniel; Beck, Frieder; Agethen, Manfred; Blischke, Klaus

    2014-06-01

    The purpose of this study was to evaluate if the catechol-O-methyltransferase-val158met (COMT)-polymorphism, which is known to affect prefrontal dopaminergic metabolism, affects the automatization of motor skills. Twenty-two participants volunteered for gene analysis after they had participated in experiments in which they practiced a single-joint arm movement sequence 460-760 times under different feedback conditions. Motor automaticity was assessed in a pre-test and a post-test according to the dual-task paradigm, which incorporated a visuo-spatial secondary task. To account for the different practice conditions in the four original studies, dual-task cost reduction was assessed using single case effect sizes proportioned to the respective group mean. For the secondary task but not for the prioritized motor task, these relative single case effect sizes proved to be positively (and significantly) correlated with the number of met-alleles on the COMT-genotype, rs=.553; p=.004. Thus, the number of met-alleles indicated a tendency toward enhanced motor automatization. Thus, due to an increased prefrontal dopamine level, met-carriers may be able to develop a well formed and stable, spatially coded movement representation early in practice, thereby supporting the formation of a representation in motor coordinates in the course of extended practice, which later enables automatic movement execution. This process might also be enhanced by a prevalence of met-carriers to functionally evaluate positive feedback information (i.e., rewards) and to better maintain recent reward information in active working memory.

  13. Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions

    Directory of Open Access Journals (Sweden)

    Winnie W Leung

    2007-01-01

    Full Text Available Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC, Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departments of Psychology and Psychiatry, Washington University, St. Louis, MO, USAAbstract: A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT, an enzyme responsible for the degradation of the catecholamine dopamine (DA, epinephrine, and norepinephrine, is associated with cognitive deficits. However, previous studies have not examined the effects of COMT on context processing, as measured by the AX-CPT, a task hypothesized to be maximally relevant to DA function. 32 individuals who were either healthy, with schizotypal personality disorder, or non-cluster A, personality disorder (OPD were genotyped at the COMT Val158Met locus. Met/Met (n = 6, Val/Met (n = 10, Val/Val (n = 16 individuals were administered a neuropsychological battery, including the AX-CPT and the N-back working memory test. For the AX-CPT, Met/Met demonstrated more AY errors (reflecting good maintenance of context than the other genotypes, who showed equivalent error rates. Val/Val demonstrated disproportionately greater deterioration with increased task difficulty from 0-back to 1-back working memory demands as compared to Met/Met, while Val/Met did not differ from either genotypes. No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation.Keywords: COMT, dopamine, context processing, working memory, schizotypal personality disorder

  14. COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

    Directory of Open Access Journals (Sweden)

    Dennis Hernaus

    Full Text Available Catechol-O-methyltransferase (COMT plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. We aimed to investigate the effect of variations in COMT genotype on in vivo measures of stress-induced prefrontal cortex (PFC dopaminergic processing and subjective stress responses. A combined sample of healthy controls and healthy first-degree relatives of psychosis patients (n = 26 were subjected to an [(18F]fallypride Positron Emission Tomography scan. Psychosocial stress during the scan was induced using the Montreal Imaging Stress Task and subjective stress was assessed every 12 minutes. Parametric t-maps, generated using the linear extension of the simplified reference region model, revealed an effect of COMT genotype on the spatial extent of [(18F]fallypride displacement. Detected effects of exposure to psychosocial stress were unilateral and remained restricted to the left superior and right inferior frontal gyrus, with Met-hetero- and homozygotes showing less [(18F]fallypride displacement than Val-homozygotes. Additionally, Met-hetero- and homozygotes experienced larger subjective stress responses than Val-homozygotes. The direction of the effects remained the same when the data was analyzed separately for controls and first-degree relatives. The human stress response may be mediated in part by COMT-dependent dopaminergic PFC activity, providing speculation for the neurobiology underlying COMT-dependent differences in human behaviour following stress. Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed.

  15. Molecular characterization of endophytes isolated from Saccharum spp based on esterase and ribosomal DNA (ITS1-5.8S-ITS2) analyses.

    Science.gov (United States)

    Leme, A C; Bevilaqua, M R R; Rhoden, S A; Mangolin, C A; Machado, M F P S; Pamphile, J A

    2013-09-27

    This study used esterases and ribosomal DNA (rDNA) markers to determine endophytic variability in order to better understand endophyte-host interactions. Polyacrylamide gel electrophoresis and esterase isoenzymes (EST; EC 3.1.1.3), with α-naphthyl acetate and β-naphthyl acetate as substrates, were used to assess relationships among endophytes. ITS1-5.8S-ITS2 sequencing data were used as rDNA markers. Thirty-two esterases were obtained from 37 isolates of Saccharum spp, which clustered into five endophyte groups. Esterase EST-06 was observed with the highest frequency, being present in 22 of the 37 isolates analyzed, followed by esterase EST-11, which was present in 20 isolates. The esterases EST-10 and EST-14 were present in 19 isolates and EST-09 was present in 18 isolates. The esterase EST-01 was unique to isolate 33 and can, therefore, be used as a marker for this isolate. None of the esterases identified were common to all isolates tested. Similarly, phylogenetic analysis, based on rDNA sequence data, classified the isolates into 5 genus groups: 1) Curvularia with a 100% bootstrap value (BP), 2) Alternaria with 100% BP, 3) Epicoccum with 60% BP, 4) Phoma with 89% BP, and 5) Saccharicola with 100% BP. This polyphyletic analysis based on several markers, therefore, proved to be a valuable approach in determining the relationship between variation in endophytes and their associated host plants. Furthermore, both the esterase and rDNA analyses obtained similar results and were equally effective in resolving relationships.

  16. Association of COMT val158met and DRD2 G>T genetic polymorphisms with individual differences in motor learning and performance in female young adults.

    Science.gov (United States)

    Noohi, Fatemeh; Boyden, Nate B; Kwak, Youngbin; Humfleet, Jennifer; Burke, David T; Müller, Martijn L T M; Bohnen, Nico I; Seidler, Rachael D

    2014-02-01

    Individuals learn new skills at different rates. Given the involvement of corticostriatal pathways in some types of learning, variations in dopaminergic transmission may contribute to these individual differences. Genetic polymorphisms of the catechol-O-methyltransferase (COMT) enzyme and dopamine receptor D2 (DRD2) genes partially determine cortical and striatal dopamine availability, respectively. Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. DRD2 G-allele homozygotes benefit from a higher striatal dopamine level compared with T-allele carriers. We hypothesized that individuals who are homozygous for COMT met and DRD2 G alleles would show higher rates of motor learning. Seventy-two young healthy females (20 ± 1.9 yr) performed a sensorimotor adaptation task and a motor sequence learning task. A nonparametric mixed model ANOVA revealed that the COMT val-val group demonstrated poorer performance in the sequence learning task compared with the met-met group and showed a learning deficit in the visuomotor adaptation task compared with both met-met and val-met groups. The DRD2 TT group showed poorer performance in the sequence learning task compared with the GT group, but there was no difference between DRD2 genotype groups in adaptation rate. Although these results did not entirely come out as one might predict based on the known contribution of corticostriatal pathways to motor sequence learning, they support the role of genetic polymorphisms of COMT val158met (rs4680) and DRD2 G>T (rs 1076560) in explaining individual differences in motor performance and motor learning, dependent on task type.

  17. TCR gamma delta cytotoxic T lymphocytes expressing the killer cell-inhibitory receptor p58.2 (CD158b) selectively lyse acute myeloid leukemia cells.

    Science.gov (United States)

    Dolstra, H; Fredrix, H; van der Meer, A; de Witte, T; Figdor, C; van de Wiel-van Kemenade, E

    2001-05-01

    Cytotoxic T lymphocytes (CTL) are thought to play an important role in the graft-versus-leukemia (GVL) response. Unfortunately, GVL reactivity is often associated with life-threatening graft-versus-host disease (GVHD). Characterization of CTL that selectively attack leukemic cells but not normal cells may lead to the development of adjuvant immunotherapy that separates GVL from GVHD. Here, we describe TCR gamma delta (V gamma 9/V delta 1) CTL, isolated from the peripheral blood of an AML patient after stem cell transplantation (SCT), that very efficiently lysed freshly isolated acute myeloid leukemia (AML) cells and AML cell lines. Interestingly, HLA-matched non-malignant hematopoietic cells were not killed. We revealed that the killer cell-inhibitory receptor (KIR) p58.2 (CD158b) specific for group 2 HLA-C molecules negatively regulates the cytotoxic effector function displayed by these TCR gamma delta CTL. First, an antibody against HLA-C enhances lysis of non-malignant cells. Secondly, stable transfection of HLA-Cw*0304 into the class I-negative cell line 721.221 inhibited lysis. Finally, engagement of p58.2 by antibodies immobilized on Fc gamma R-expressing murine P815 cells inhibits CD3- and TCR gamma delta-directed lysis. Compared to non-malignant hematopoietic cells, AML cells express much lower levels of MHC class I molecules making them susceptible to lysis by p58.2(+) TCR gamma delta CTL. Such KIR-regulated CTL reactivity may have a role in the GVL response without affecting normal tissues of the host and leading to GVHD.

  18. Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission

    Directory of Open Access Journals (Sweden)

    Alexandre A. Loch

    2015-09-01

    Full Text Available Objective:To assess the relationship between cognitive function, a proposed schizophrenia endophenotype, and two genetic polymorphisms related to dopamine function, catechol-O-methyl transferase (COMT Val158Met and dopamine receptor 3 (DRD3 Ser9Gly.Methods:Fifty-eight outpatients with schizophrenia/schizoaffective disorder and 88 healthy controls underwent neurocognitive testing and genotyping. Analyses of covariance (ANCOVAs using age, sex, and years of education as covariates compared cognitive performance for the proposed genotypes in patients and controls. ANCOVAs also tested for the epistatic effect of COMT and DRD3 genotype combinations on cognitive performance.Results:For executive functioning, COMT Val/Val patients performed in a similar range as controls (30.70-33.26 vs. 35.53-35.67, but as COMT Met allele frequency increased, executive functioning worsened. COMT Met/Met patients carrying the DRD3 Ser/Ser genotype performed poorest (16.184 vs. 27.388-31.824. Scores of carriers of this COMT/DRD3 combination significantly differed from all DRD3 Gly/Gly combinations (p < 0.05, from COMT Val/Met DRD3 Ser/Gly (p = 0.02, and from COMT Val/Val DRD3 Ser/Ser (p = 0.01 in patients. It also differed significantly from all control scores (p < 0.001.Conclusion:Combined genetic polymorphisms related to dopamine neurotransmission might influence executive function in schizophrenia. Looking at the effects of multiple genes on a single disease trait (epistasis provides a comprehensive and more reliable way to determine genetic effects on endophenotypes.

  19. ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells.

    Science.gov (United States)

    Xu, Jianliang; Lim, Sophia Beng Hui; Ng, Mei Yong; Ali, Safiah Mohamed; Kausalya, Jaya P; Limviphuvadh, Vachiranee; Maurer-Stroh, Sebastian; Hunziker, Walter

    2012-09-01

    ZO-1/Tjp1 is a cytosolic adaptor that links tight junction (TJ) transmembrane proteins to the actin cytoskeleton and has also been implicated in regulating cell proliferation and differentiation by interacting with transcriptional regulators and signaling proteins. To explore possible roles for ZO-1 in mouse embryonic stem cells (mESCs), we inactivated the ZO-1 locus by homologous recombination. The lack of ZO-1 was found to affect mESC self-renewal and differentiation in the presence of leukemia-inhibiting factor (LIF) and Bmp4 or following removal of the growth factors. Our data suggest that ZO-1 suppresses Stat3 and Smad1/5/8 activities and sustains extracellular-signal-regulated kinase (Erk) activity to promote mESC differentiation. Interestingly, Smad2, critical for human but not mESC self-renewal, was hyperactivated in ZO-1(-/-) mESCs and RhoA protein levels were concomitantly enhanced, suggesting attenuation of the noncanonical transforming growth factor β (Tgfβ)/Activin/Nodal pathway that mediates ubiquitination and degradation of RhoA via the TJ proteins Occludin, Par6, and Smurf1 and activation of the canonical Smad2-dependent pathway. Furthermore, Bmp4-induced differentiation of mESCs in the absence of LIF was suppressed in ZO-1(-/-) mESCs, but differentiation down the neural or cardiac lineages was not disturbed. These findings reveal novel roles for ZO-1 in mESC self-renewal, pluripotency, and differentiation by influencing several signaling networks that regulate these processes. Possible implications for the differing relevance of Smad2 in mESC and human ESC self-renewal and how ZO-1 may connect to the different pathways are discussed.

  20. Use of drugs for ADHD among adults-a multinational study among 15.8 million adults in the Nordic countries.

    Science.gov (United States)

    Karlstad, Øystein; Zoëga, Helga; Furu, Kari; Bahmanyar, Shahram; Martikainen, Jaana E; Kieler, Helle; Pottegård, Anton

    2016-12-01

    The use of ADHD drugs among adults is controversial and has until recently not been approved for use in adults in most countries. The aim was to investigate use of ADHD drugs (stimulants and atomoxetine) among the entire adult population in the Nordic countries. We conducted a multinational population-based prescription register study based on the entire adult population in the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). All users of ADHD drugs aged 18-64 years during 2008-2012 were included, which for 2012 comprised 76,896 drug users among 15.8 million adult inhabitants. Annual prevalence of drug use increased during the study period for both genders and all age groups. The overall prevalence increased from 2.4 to 5.3 per 1000 men and 1.8 to 4.4 per 1000 women. Incidence also increased, but to a lesser extent in the last part of the study period. Methylphenidate was used by 88 % of drug users. Treatment was discontinued within the first year by 21 % of new drug users. Among all users of ADHD drugs, 53 % of men and 64 % of women concurrently used other psychotropic drugs, most frequently antidepressants and hypnotics. Psychotropic co-medication increased with age and was more pronounced among women than men. Use of ADHD drug among adults more than doubled over a 5-year period, and a majority were concurrently treated with other psychotropics. Adults constitute a substantial proportion of persons treated with ADHD drugs. Thus, evidence for long-term efficacy and safety in adults is urgently needed.

  1. Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.

    Science.gov (United States)

    Zarrouk, Amira; Nury, Thomas; Karym, El-Mostafa; Vejux, Anne; Sghaier, Randa; Gondcaille, Catherine; Andreoletti, Pierre; Trompier, Doriane; Savary, Stéphane; Cherkaoui-Malki, Mustapha; Debbabi, Meryam; Fromont, Agnès; Riedinger, Jean-Marc; Moreau, Thibault; Lizard, Gérard

    2016-02-24

    Mitochondrial dysfunctions and oxidative stress are involved in several non demyelinating or demyelinating neurodegenerative diseases. Some of them, including multiple sclerosis (MS), are associated with lipid peroxidation processes leading to increased levels of 7-ketocholesterol (7KC). So, the eventual protective effect of dimethylfumarate (DMF), which is used for the treatment of MS, was evaluated on 7KC-treated oligodendrocytes, which are myelin synthesizing cells. To this end, murine oligodendrocytes 158N were exposed to 7KC (25, 50μM) for 24h without or with DMF (1, 25, 50μM). The biological activities of DMF associated or not with 7KC were evaluated by phase contrast microscopy, crystal violet and MTT tests. The impact on transmembrane mitochondrial potential (ΔYm), O2(-) and H2O2 production, apoptosis and autophagy was measured by microscopical and flow cytometric methods by staining with DiOC6(3), dihydroethidine and dihydrorhodamine 123, Hoechst 33342, and by Western blotting with the use of specific antibodies raised against uncleaved and cleaved caspase-3 and PARP, and LC3-I/II. DMF attenuates the different effects of 7KC, namely: cell growth inhibition and/or loss of cell adhesion, decrease of ΔΨm, O2(-) and H2O2 overproduction, PARP and caspase-3 cleavage, nuclear condensation and fragmentation, and activation of LC3-I into LC3-II. The ability of DMF to attenuate 7KC-induced reactive oxygen species overproduction, apoptosis, and autophagy on oligodendrocytes reinforces the interest for this molecule for the treatment of MS or other demyelinating diseases.

  2. System-size and centrality dependence of charged kaon and pion production in nucleus-nucleus collisions at 40A GeV and158A GeV beam energy

    CERN Document Server

    Anticic, T.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; Bogusz, M.; Boimska, B.; Book, J.; Botje, M.; Buncic, P.; Cetner, T.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, J.G.; Dinkelaker, P.; Eckardt, V.; Fodor, Z.; Foka, P.; Friese, V.; Gazdzicki, M.; Grebieszkow, K.; Hohne, C.; Kadija, K.; Karev, A.; Kliemant, M.; Kolesnikov, V.I.; Kollegger, T.; Kowalski, M.; Kresan, D.; Laszlo, A.; Lacey, R.; van Leeuwen, M.; Lungwitz, B.; Mackowiak, M.; Makariev, M.; Malakhov, A.I.; Mateev, M.; Melkumov, G.L.; Mitrovski, M.; Mrowczynski, St.; Nicolic, V.; Palla, G.; Panagiotou, A.D.; Peryt, W.; Pluta, J.; Prindle, D.; Puhlhofer, F.; Renfordt, R.; Roland, C.; Roland, G.; Rybczynski, M.; Rybicki, A.; Sandoval, A.; Schmitz, N.; Schuster, T.; Seyboth, P.; Sikler, F.; Skrzypczak, E.; Slodkowski, M.; Stefanek, G.; Stock, R.; Strobele, H.; Susa, T.; Szuba, M.; Utvic, M.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A.

    2012-01-01

    Measurements of charged pion and kaon production are presented in centrality selected Pb+Pb collisions at 40A GeV and 158A GeV beam energy as well as in semi-central C+C and Si+Si interactions at 40A GeV. Transverse mass spectra, rapidity spectra and total yields are determined as a function of centrality. The system-size and centrality dependence of relative strangeness production in nucleus-nucleus collisions at 40A GeV and 158A GeV beam energy are derived from the data presented here and published data for C+C and Si+Si collisions at 158A GeV beam energy. At both energies a steep increase with centrality is observed for small systems followed by a weak rise or even saturation for higher centralities. This behavior is compared to calculations using transport models (UrQMD and HSD), a percolation model and the core-corona approach.

  3. Prospective study of 158 adult scoliosis treated by a bivalve polyethylene overlapping brace and reviewed at least 5 years after brace fitting

    Directory of Open Access Journals (Sweden)

    Jean Claude de Mauroy

    2016-10-01

    Full Text Available Abstract Background The conservative orthopaedic treatment of adult scoliosis is very disappointing. In a series of 144 patients; only 25 % (33 cases were monitored at 2 years of treatment. (Papadopoulos 2013. Thereby the literature typically focuses on a small number of patients, which limits the usefulness and relevance of its results. The brace effect on pain has been systematically described, but there is no publication on the effect of treatment on the Cobb angle and main clinical parameters. Methods From a prospective database started in 1998, we selected all 158 consecutive patients effectively treated conservatively with the Lyon management treatment and controlled five years after brace fitting. Lyon management includes a lordosing bivalve polyethylene overlapping brace in association with specific physiotherapy. The brace can either be short with anterior support under the chest or long with sterno-clavicular support when there is a high thoracic kyphosis. Results 1. For the rate of scoliosis controlled after 5 years, the follow-up was 24 % of the 661 patients accepting the treatment. Pain is almost the main reason for the medical consultation, generally correlating with an increase of the scoliotic angulation. 2. The descriptive data can be superimposed on general group with age (m=56 years, SD=13 but initial Cobb angulation is significantly higher (m=40°, SD=17. Ratio Female/Male=0.91. Generally, the scoliosis is stabilized at (m=39.74 °, SD=19.40, 8 years after the beginning of the treatment. 38 improvements of more than 5°= 24 %; 88 stable = 56 %; 32 worsening of more than 5° = 20 % The rib hump is improved of by 3 mm, (modelling effect of the brace. The occipital axis is improved by more than 6 mm. But the T1 plumb line distance is worsening by 7 mm (most braces are short without sterno-clavicular support. Conclusions For the first time, the number of records and follow up after 8 years allows to study the

  4. Kaon and pion production in centrality selected minimum bias Pb+Pb collisions at 40 and 158 A.GeV

    Energy Technology Data Exchange (ETDEWEB)

    Dinkelaker, Peter

    2009-07-01

    Results on charged kaon and negatively charged pion production and spectra for centrality selected Pb+Pb minimum bias events at 40 and 158A GeV have been presented in this thesis. All analysis are based on data taken by the NA49 experiment at the accelerator Super Proton Synchrotron (SPS) at the European Organization for Nuclear Research (CERN) in Geneva, Switzerland. The kaon results are based on an analysis of the mean energy loss of the charged particles traversing the detector gas of the time projection chambers (TPCs). The pion results are from an analysis of all negatively charged particles h{sup -} corrected for contributions from particle decays and secondary interactions. For the dE/dx analysis of charged kaons, main TPC tracks with a total momentum between 4 and 50 GeV have been analyzed in logarithmic momentum log(p) and transverse momentum p{sub t} bins. The resulting dE/dx spectra have been fitted by the sum of 5 Gaussians, one for each main particle type (electrons, pions, kaons, protons, deuterons). The amplitude of the Gaussian used for the kaon part of the spectra has been corrected for efficiency and acceptance and the binning has been transformed to rapidity y and transverse momentum pt bins. The multiplicity dN/dy of the single rapidity bins has been derived by summing the measured range of the transverse momentum spectra and an extrapolation to full coverage with a single exponential function fitted to the measured range. The results have been combined with the mid-rapidity measurements from the time-of-flight detectors and a double Gaussian fit to the dN/dy spectra has been used for extrapolation to rapidity outside of the acceptance of the dE/dx analysis. For the h{sup -} analysis of negatively charged pions, all negatively charged tracks have been analyzed. The background from secondary reactions, particle decays, and gamma-conversions has been corrected with the VENUS event generator. The results were also corrected for efficiency

  5. 1-对甲苯磺酰基-3-羟基-1,5,8-三氮杂环癸烷的合成及与DNA的相互作用研究%Synthesis of 1-Tosyl-3-hydroxyl-1,5,8-triazacyclodecane and Its Interaction with DNA

    Institute of Scientific and Technical Information of China (English)

    李涛; 吴晓军; 梁峰; 熊小琴; 杨利; 周泱泱; 吴成泰

    2011-01-01

    通过控制反应条件,制备得到1-对甲苯磺酰基-3-羟基-1,5,8-三氮杂环癸烷(2).根据谱学数据确定目标化合物2的结构,应用DNA熔点温度测量和计算机模拟研究测定化合物2~4与DNA的结合能力.结果显示羟基和对甲苯磺酰基的引入有利于化合物2与DNA的结合.在37℃生理条件作用下,不需要金属离子辅助,大环配体2可使超螺旋型pBR322DNA断裂,同时得到切口开环型和线形DNA.并且,化合物2对肺癌细胞有选择性抑制作用.因此,这种先导化合物可以用于人工核酸酶及抗肿瘤药物设计.%In this paper, 1-tosyl-3-hydroxyl-1,5,8-triazacyclodecane (2) was prepared in optimized conditions. The structure of title compound 2 was established on the basis of spectroscopic data. The binding of compounds 2, 3, 4 to DNA was investigated with melting temperature measurements and molecular-modeling calculations The results showed that the introduction of hydroxyl and tosyl groups into triazacyclicamines may enhance the interaction between the compound Z and DNA. The free macrocyclic ligand 2 could catalyze cleavage supercoiled pBR322 DNA to the nicked and the linear form at the same time at near neutral conditions and 37 ℃ without any metal ions aid. In addition, compound 2 showed selectively inhibition to lung cancer cells. Thus, this leading compound might be useful as artificial restriction enzymes and may be usefully applied in the development of anti-tumor drug.

  6. Cross sections of production of J / {psi}, {psi}` resonances and of the Drell-Yan process in the Pb-Pb interactions with 158 GeV / c per nucleon; Section efficaces de production des resonances J / {psi}, {psi}` et du processus Drell-Yan dans les interactions Pb-Pb a 158 GeV / c par nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Bellaiche, F

    1997-04-24

    In the framework of the experimental research for the quark and gluons plasma formation in ultrarelativistic heavy ion collisions, data obtained by the NA50 collaboration at SPS-CERN are analysed. The segmented target used by NA50 experiment is described and analysed in terms of vertex identification efficiency and re-interactions recognition. The absolute J/{psi}, {psi}`and Drell-Yan process cross-sections in 158 GeV/c per nucleon Pb-Pb interactions are extracted. The transverse energy dependence of the production yield of J/{psi} and Drell-Yan process is established. The comparison of these cross-sections with the ones measured in lighter systems and the comparison of the E dependence of J/{psi} production with the Glauber model prediction show an anomalous J/{psi} suppression observed in Pb-Pb interactions is confronted to theoretical models proposed by several authors, describing charmonium bound states formation and interactions is confronted to theoretical models proposed by several authors, describing charmonium bound states formation and interactions in confined or deconfined media. (author) 122 refs.

  7. Impact parameter dependence of K+/-, p, pbar, d and dbar production in fixed-target Pb + Pb collisions at 158 GeV/nucleonImpact parameter dependence of K+/-, p, pbar, d and dbar production in fixed-target Pb + Pb collisions at 158 GeV/nucleon

    Science.gov (United States)

    NA52 Collaboration; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Hess, P.; Kabana, S.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Tuominiemi, J.; Weber, M.

    1999-12-01

    Nuclear matter is expected to undergo a phase transition to quark matter in ultrarelativistic heavy-ion collisions, possibly showing up as a discontinuity in the impact parameter dependence of relevant observables. Following this expectation, we have investigated the impact parameter dependence of the invariant yields of K+/-, p, d, pbar and dbar in the range ~ 2 - 12 fm in fixed-target Pb+Pb collisions at 158 GeV/nucleon incident energy at the CERN SPS. The particles have been measured near zero transverse momentum and in the rapidity range y = 3.1 - 4.4. In addition, the centrality dependence of the baryon chemical potential, the effective temperature and the size of the particle emitting source at freeze-out were studied. No dramatic change in the distribution of any of these variables is observed as a function of the impact parameter. The same is found for the particle yields, with the exception of the yield of charged kaons per number of nucleons participating in the collision (Np), where there is an indication of a threshold behaviour at Np~80.

  8. Dysprosium-free melt-spun permanent magnets.

    Science.gov (United States)

    Brown, D N; Wu, Z; He, F; Miller, D J; Herchenroeder, J W

    2014-02-12

    Melt-spun NdFeB powders can be formed into a number of different types of permanent magnet for a variety of applications in electronics, automotive and clean technology industries. The melt-spinning process produces flake powder with a fine uniform array of nanoscale Nd2Fe14B grains. These powders can be net-shape formed into isotropic polymer-bonded magnets or hot formed into fully dense magnets. This paper discusses the influence of heavy rare earth elements and microstructure on the magnetic performance, thermal stability and material cost of NdFeB magnets. Evidence indicates that melt-spun nanocrystalline NdFeB magnets are less dependent on heavy rare earth elements for high-temperature performance than the alternative coarser-grained sintered NdFeB magnets. In particular, hot-pressed melt-spun magnets are an attractive low-cost solution for applications that require thermal stability up to 175-200 °C.

  9. Structural and magnetic study of dysprosium substituted cobalt ferrite nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Hemaunt, E-mail: hvatsal@gmail.com [Department of Physics, Govind Ballabh Pant University of Agr. & Technology, Pantnagar, Uttarakhand 263145 (India); Srivastava, R.C. [Department of Physics, Govind Ballabh Pant University of Agr. & Technology, Pantnagar, Uttarakhand 263145 (India); Pal Singh, Jitendra [Advanced Analysis Centre, Korea Institute of Science and Technology, Seoul 02792 (Korea, Republic of); Negi, P. [Department of Physics, Govind Ballabh Pant University of Agr. & Technology, Pantnagar, Uttarakhand 263145 (India); Agrawal, H.M. [Advanced Analysis Centre, Korea Institute of Science and Technology, Seoul 02792 (Korea, Republic of); Das, D. [UGC-DAE CSR Kolkata Centre, Kolkata 700098 (India); Hwa Chae, Keun [Advanced Analysis Centre, Korea Institute of Science and Technology, Seoul 02792 (Korea, Republic of)

    2016-03-01

    The present work investigates the magnetic behavior of Dy{sup 3+} substituted cobalt ferrite nanoparticles. X-ray diffraction studies reveal presence of cubic spinel phases in these nanoparticles. Raman spectra of these nanoparticles show change in intensity of Raman bands, which reflects cation redistribution in cubic spinel lattice. Saturation magnetization and coercivity decrease with increase of Dy{sup 3+}concentration in these nanoparticles. Room temperature Mössbauer measurements show the cation redistribution in these nanoparticles and corroborates the results obtained from Raman Spectroscopic measurements. Decrease in magnetization of Dy{sup 3+} substituted cobalt ferrite is attributed to the reduction in the magnetic interaction and cation redistribution. - Highlights: • Slight decrease in crystallite size after Dy{sup 3+} doping. • Saturation magnetization and coercivity decrease after Dy{sup 3+} doping. • Mössbauer measurements show the cation redistribution in the samples.

  10. Dysprosium Acetylacetonato Single-Molecule Magnet Encapsulated in Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Ryo Nakanishi

    2016-12-01

    Full Text Available Dy single-molecule magnets (SMMs, which have several potential uses in a variety of applications, such as quantum computing, were encapsulated in multi-walled carbon nanotubes (MWCNTs by using a capillary method. Encapsulation was confirmed by using transmission electron microscopy (TEM. In alternating current magnetic measurements, the magnetic susceptibilities of the Dy acetylacetonato complexes showed clear frequency dependence even inside the MWCNTs, meaning that this hybrid can be used as magnetic materials in devices.

  11. Microscopic study of neutron-rich dysprosium isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Vargas, Carlos E. [Universidad Veracruzana, Facultad de Fisica e Inteligencia Artificial, Xalapa (Mexico); Universidad Nacional Autonoma de Mexico, Facultad de Ciencias, Apartado Postal 70-542, Mexico D.F. (Mexico); Velazquez, Victor [Universidad Nacional Autonoma de Mexico, Facultad de Ciencias, Apartado Postal 70-542, Mexico D.F. (Mexico); Lerma, Sergio [Universidad Veracruzana, Facultad de Fisica e Inteligencia Artificial, Xalapa (Mexico)

    2013-01-15

    Microscopic studies in heavy nuclei are very scarce due to large valence spaces involved. This computational problem can be avoided by means of the use of symmetry-based models. Ground-state, {gamma} and {beta} bands, and their B(E2) transition strengths in {sup 160-168}Dy isotopes, are studied in the framework of the pseudo-SU(3) model which includes the preserving symmetry Q . Q term and the symmetry-breaking Nilsson and pairing terms, systematically parametrized. Additionally, three rotor-like terms are considered, whose free parameters, fixed for all members of the chain, are used to fine tune the moment of inertia of rotational bands and the band head of {gamma} and {beta} bands. The model succesfully describes in a systematic way rotational features in these nuclei and allows to extrapolate toward the midshell nucleus {sup 170}Dy. The results presented show that it is possible to study a full chain of isotopes or isotones in the region with the present model. (orig.)

  12. Photodissociation spectroscopy of the dysprosium monochloride molecular ion

    CERN Document Server

    Dunning, Alexander; Showalter, Steven J; Puri, Prateek; Kotochigova, Svetlana; Hudson, Eric R

    2015-01-01

    We have performed a combined experimental and theoretical study of the photodissociation cross section of the molecular ion DyCl$^+$. The cross section for the photon energy range 35,500 cm$^{-1}$ to 47,500 cm$^{-1}$ is measured using an integrated ion trap and time-of-flight mass spectrometer, and we observe a broad, asymmetric profile that is peaked near 43,000 cm$^{-1}$. The theoretical cross section is determined from electronic potentials and transition dipole moments calculated using the relativistic configuration-interaction valence-bond and coupled-cluster methods. The electronic structure of DyCl$^+$ is unprecedentedly complex due to the presence of multiple open electronic shells, including 4f$^{10}$ orbitals. The molecule has nine attractive potentials with ionically-bonded electrons and 99 repulsive potentials dissociating to a ground state Dy$^+$ ion and Cl atom. We explain the lack of symmetry in the cross section as due to multiple contributions from one-electron-dominated transitions between t...

  13. FTIR and Electrical Study of Dysprosium Doped Cobalt Ferrite Nanoparticles

    Directory of Open Access Journals (Sweden)

    Hemaunt Kumar

    2014-01-01

    Full Text Available We have studied the role of Dy3+ doping on the XRD, TEM, FTIR, and dielectric and electrical properties of CoFe2O4 at room temperature. Cubic spinel phase of CoFe2−xDyxO4 (x = 0.00, 0.05, 0.10, and 0.15 was synthesized by using different sintering temperatures (300, 500, 700, and 900°C. The two absorption bands ν1 and ν2 are observed in Fourier transform infrared spectroscopy (FTIR spectra corresponding to the tetrahedral and octahedral sites, which show signature of spinel structure of the sample. For the sample sintered at 300°C, the dielectric constant is almost unchanged with the frequency at the particular concentrations of x = 0.00 and 0.05. Similar result is obtained for the sample sintered at 500°C (x = 0.10, 0.15, 700°C (x = 0.05, 0.10, and 0.15, and 900°C (x = 0.05, 0.10. An increase in the dielectric constant was observed for the undoped cobalt ferrite sintered at 500, 700, and 900°C. The values of electrical resistivity of the materials vary from ~105 to 109 Ω-cm.

  14. Adsorption of D113 Resin for Dysprosium(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The adsorption behavior and mechanism of D113 resin for Dy(Ⅲ) was investigated by using the method of resin adsorption. Experimental results show that the optimum medium pH of adsorption of D113 resin for Dy3+ is pH=6.00 in the HAc-NaAc medium. The static adsorption capacity of D113 resin for Dy3+chemical analysis and IR spectra.

  15. 1300-nm gain obtained with dysprosium-doped chloride crystals

    Energy Technology Data Exchange (ETDEWEB)

    Page, R.H.; Schaffers, K.I.; Beach, R.J.; Payne, S.A.; Krupke, W.F.

    1996-03-01

    Dy{sup 3+} - doped chloride crystals have high 1300-nm emission quantum yields. Pump - probe experiments on La Cl{sub 3}:Dy{sup 3+} demonstrate optical gain consistent with predictions based on spectroscopic cross sections and lifetimes.

  16. Microscopic study of neutron-rich Dysprosium isotopes

    CERN Document Server

    Vargas, Carlos E; Lerma, Sergio; 10.1140/epja/i2013-13004-1

    2013-01-01

    Microscopic studies in heavy nuclei are very scarce due to large valence spaces involved. This computational problem can be avoided by means of the use of symmetry based models. Ground-state, gamma and beta-bands, and their B(E2) transition strengths in 160-168Dy isotopes, are studied in the framework of the pseudo-SU(3) model which includes the preserving symmetry Q.Q term and the symmetry-breaking Nilsson and pairing terms, systematically parametrized. Additionally, three rotor-like terms are considered whose free parameters, fixed for all members of the chain are used to fine tune the moment of inertia of rotational bands and the band-head of gamma and beta-bands. The model succesfully describes in a systematic way rotational features in these nuclei and allows to extrapolate toward the midshell nucleus 170Dy. The results presented show that it is possible to study full chain of isotopes or isotones in the region with the present model.

  17. Visible luminescence of dysprosium ions in oxyhalide lead borate glasses

    Science.gov (United States)

    Pisarska, Joanna; Żur, Lidia; Pisarski, Wojciech A.

    2011-08-01

    Visible luminescence of Dy 3+ ions in oxyhalide lead borate glasses was examined. Luminescence spectra show two intense bands at 480 nm and 573 nm due to 4F 9/2 → 6H 15/2 (blue) and 4F 9/2 → 6H 13/2 (yellow) transitions of Dy 3+. Luminescence decays from 4F 9/2 state and yellow-to-blue luminescence intensity ratios (Y/B) were analysed with PbX 2 (X = F, Cl) content. An introduction of PbX 2 to the borate glass results in the increasing of 4F 9/2 lifetime and the decreasing of yellow-to-blue luminescence intensity ratio, which is due to reduction of covalency between Dy 3+ and O 2-/X - ions.

  18. MAGNETIC FIELD INDUCED FIRST-ORDER TRANSITIONS IN DYSPROSIUM ORTHOFERRITE

    OpenAIRE

    Eremenko, V.; Gnatchenko, S.; Kharchenko, N.; Lebedev, P.; Piotrowski, K; Szymczak, H.; Szymczak, R.

    1988-01-01

    New type of magnetic first-order phase transition induced by external magnetic field applied in the ab-plane in DyFeO3 is investigated using different magnetooptic techniques. The phenomenological model of this transition is proposed. The phase diagram in H-T plane has been obtained for various H orientation in the ab-plane.

  19. Analysis of clinical characteristic of 158 inpatients with dengue fever in Guangzhou area during the 2014 epidemic%2014年广州地区158例登革热住院患者临床特征分析

    Institute of Scientific and Technical Information of China (English)

    叶子; 黄应雄; 蒋鹏; 郑梓煜; 熊艳; 徐嘉; 肖孝勇; 詹红

    2015-01-01

    目的:探讨登革热住院患者的临床特征,为登革热的临床诊治提供参考依据。方法回顾性分析2014年7月23日至10月31日广州地区登革热暴发期间,中山大学附属第一医院收治的158例登革热住院患者的病例资料,记录患者的一般资料、常规临床检查和病原学检查结果以及预后,并进行描述性统计分析。结果158例登革热住院患者平均年龄(56±20)岁,≥60岁者79例(占50.00%),男性94例(占59.49%)。①主要临床表现:发热(100%)、头痛(70.89%)、骨骼/肌肉疼痛(62.03%)、皮疹(54.43%);部分患者有出血(25.95%)和血浆渗漏表现(14.56%)。②实验室检查:多数患者表现为白细胞总数降低(75.32%)、血小板减少(77.85%)、丙氨酸转氨酶(ALT)升高(57.59%)、天冬氨酸转氨酶(AST)升高(77.85%),但血细胞比容(HCT)增高者较少见(1.27%)。③病原学检查:急性期(起病0~5 d)血清登革热IgM抗体(DF-IgM)阳性率为63.54%(61/96),登革热病毒核酸(DENV-RNA)阳性率为92.62%(113/122)。④基础疾病:87例(占55.06%)合并基础疾病,最常见为高血压(27.22%)和2型糖尿病(15.82%)。⑤治疗措施:隔离患者直至病程超过5 d,且热退24 h以上,以对症支持治疗和及时防治各种并发症为主。⑥预后:重症登革热18例(占11.39%),其中1例死于消化道大出血,1例合并多器官功能障碍综合征(MODS)未愈出院,另有2例院内感染普通登革热患者死于原发心脑血管疾病,余154例(占97.47%)患者经对症支持治疗后均痊愈出院。结论本组登革热住院患者临床表现典型,且重症发生率较高。DENV-RNA检测是早期病原学诊断的敏感指标。经对症支持治疗大部分登革热患者预后良好,但对重症患者的早期识别和治疗干预方式

  20. Oceanographic profile data collected from CTD and sound velocimeter - moving vessel profiler casts aboard NOAA Ship FAIRWEATHER as part of project OPR-P158-FA-09 in the Gulf of Alaska from 2009-09-09 to 2009-09-22 (NCEI Accession 0130817)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0130817 includes physical and profile data collected aboard NOAA Ship FAIRWEATHER during project OPR-P158-FA-09 in the Gulf of Alaska from 2009-09-09...