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Sample records for drumming reveals common

  1. Monkey drumming reveals common networks for perceiving vocal and nonvocal communication sounds.

    Science.gov (United States)

    Remedios, Ryan; Logothetis, Nikos K; Kayser, Christoph

    2009-10-20

    Salient sounds such as those created by drumming can serve as means of nonvocal acoustic communication in addition to vocal sounds. Despite the ubiquity of drumming across human cultures, its origins and the brain regions specialized in processing such signals remain unexplored. Here, we report that an important animal model for vocal communication, the macaque monkey, also displays drumming behavior, and we exploit this finding to show that vocal and nonvocal communication sounds are represented by overlapping networks in the brain's temporal lobe. Observing social macaque groups, we found that these animals use artificial objects to produce salient periodic sounds, similar to acoustic gestures. Behavioral tests confirmed that these drumming sounds attract the attention of listening monkeys similarly as conspecific vocalizations. Furthermore, in a preferential looking experiment, drumming sounds influenced the way monkeys viewed their conspecifics, suggesting that drumming serves as a multimodal signal of social dominance. Finally, by using high-resolution functional imaging we identified those brain regions preferentially activated by drumming sounds or by vocalizations and found that the representations of both these communication sounds overlap in caudal auditory cortex and the amygdala. The similar behavioral responses to drumming and vocal sounds, and their shared neural representation, suggest a common origin of primate vocal and nonvocal communication systems and support the notion of a gestural origin of speech and music.

  2. FAILURE ANALYSIS: WASTEWATER DRUM BULGING

    Energy Technology Data Exchange (ETDEWEB)

    Vormelker, P

    2008-09-15

    A 55 gallon wastewater drum lid was found to be bulged during storage in a remote area. Drum samples were obtained for analysis. The interior surface of these samples revealed blistering and holes in the epoxy phenolic drum liner and corrosion of the carbon steel drum. It is suspected that osmotic pressure drove permeation of the water through the epoxy phenolic coating which was weakened from exposure to low pH water. The coating failed at locations throughout the drum interior. Subsequent corrosion of the carbon steel released hydrogen which pressurized the drum causing deformation of the drum lid. Additional samples from other wastewater drums on the same pallet were also evaluated and limited corrosion was visible on the interior surfaces. It is suspected that, with time, the corrosion would have advanced to cause pressurization of these sealed drums.

  3. L AREA WASTEWATER STORAGE DRUM EVALUATION

    Energy Technology Data Exchange (ETDEWEB)

    Vormelker, P; Cynthia Foreman, C; Zane Nelson, Z; David Hathcock, D; Dennis Vinson, D

    2007-11-30

    This report documents the determination of the cause of pressurization that led to bulging deformation of a 55 gallon wastewater drum stored in L-Area. Drum samples were sent to SRNL for evaluation. The interior surface of these samples revealed blistering and holes in the epoxy phenolic drum liner and corrosion of the carbon steel drum. It is suspected that osmotic pressure drove permeation of the water through the epoxy phenolic coating which was weakened from exposure to low pH water. The coating failed at locations throughout the drum interior. Subsequent corrosion of the carbon steel released hydrogen which pressurized the drum causing deformation of the drum lid. Additional samples from other wastewater drums on the same pallet were also evaluated and limited corrosion was visible on the interior surfaces. It is suspected that, with time, the corrosion would have advanced to cause pressurization of these sealed drums.

  4. Avalanche dynamics of granular materials under the slumping regime in a rotating drum as revealed by speckle visibility spectroscopy.

    Science.gov (United States)

    Yang, H; Li, R; Kong, P; Sun, Q C; Biggs, M J; Zivkovic, V

    2015-04-01

    We used speckle visibility spectroscopy to measure the time-resolved dynamcis of avalanching down the inclined surface of a granular material in a half-full rotating drum operating in the slumping regime. The distribution of the avalanche period, t(d), rest time between them, t(r), and peak particle velocity fluctuation, δv(p)(2), are all normally distributed. While the distributions of the two times at the top and bottom of the free surface are very similar, the particle velocity fluctuation is greater at the bottom of the free surface than at the top. The rest time is observed to be inversely related to the drum speed. Combining this with the relation of t(r) and the difference of the upper and lower angle of repose for the granular material, Δθ, we find that the latter decreases linearly with increasing rotational speed. We also observe that t(d) increases in a linear fashion with the drum speed. Using the relation of t(r) and the distance that particles have to move during an avalanche, we further find that a new scaling relation of the mean number of avalanches required to traverse the free surface with drum speed. We find that the slumping frequency increases with the rotating speed before becoming constant in the slumping-to-rolling transition region. Finally, we find that the average peak of the fluctuation speed of the avalanche, δv(p)(2), increases linearly with the drum speed.

  5. Bronze Drum

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Drums were frequently used to direct the army to move ahead or retreat as well as to dance at feasts and at sacrificial rites to gods or ancestors. According to legend, Emperor Huangdi who ruled before 2140 B.C. had a

  6. Drum Screen Preventing Corrosion Protection and Common Issue Prevention%鼓形旋转滤网腐蚀防护及常见问题预防

    Institute of Scientific and Technical Information of China (English)

    孙宗旭; 黄海滨

    2015-01-01

    本文简要介绍了腐蚀的定义及腐蚀防护的基本方法,对鼓形旋转滤网腐蚀防护的难点及国内常见腐蚀防护方法的选择做了分析,并结合工程实践经验对鼓形旋转滤网腐蚀防护常见的问题进行了分析,提出了预防措施及解决办法,为工程施工过程提供参考依据。%This paper introduces the definition of corrosion and basic methods of corrosion protection. It analyzes the difficulties in corrosion protection of drum screen and the choice of common domestic corrosion protection method. According to engineering experience, common issues of corrosion protection of drum screen are also analyzed. It provides preventive measures and solutions for construction projects for reference.

  7. Over-Pressurized Drums: Their Causes and Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, Fred; Kuntamukkula, Murty; Quigley, David; Robertson, Janeen; Freshwater, David

    2009-07-10

    Having to contend with bulging or over-pressurized drums is, unfortunately, a common event for people storing chemicals and chemical wastes. (Figure 1) The Department of Energy alone reported over 120 incidents of bulging drums between 1992 and 1999 (1). Bulging drums can be caused by many different mechanisms, represent a number of significant hazards and can be tricky to mitigate. In this article, we will discuss reasons or mechanisms by which drums can become over-pressurized, recognition of the hazards associated with and mitigation of over-pressurized drums, and methods that can be used to prevent drum over-pressurization from ever occurring. Drum pressurization can represent a significant safety hazard. Unless recognized and properly mitigated, improperly manipulated pressurized drums can result in employee exposure, employee injury, and environmental contamination. Therefore, recognition of when a drum is pressurized and knowledge of pressurized drum mitigation techniques is essential.

  8. Drum Performance Tnvolues Women

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    DRUM teams from along the Yellow River are known not only in China but by many foreign friends. Recently women have formed their own teams and their performances have further increased the popularity of this ancient Chinese folk art.

  9. A systems biology approach reveals common metastatic pathways in osteosarcoma

    Directory of Open Access Journals (Sweden)

    Flores Ricardo J

    2012-05-01

    Full Text Available Abstract Background Osteosarcoma (OS is the most common malignant bone tumor in children and adolescents. The survival rate of patients with metastatic disease remains very dismal. Nevertheless, metastasis is a complex process and a single-level analysis is not likely to identify its key biological determinants. In this study, we used a systems biology approach to identify common metastatic pathways that are jointly supported by both mRNA and protein expression data in two distinct human metastatic OS models. Results mRNA expression microarray and N-linked glycoproteomic analyses were performed on two commonly used isogenic pairs of human metastatic OS cell lines, namely HOS/143B and SaOS-2/LM7. Pathway analysis of the differentially regulated genes and glycoproteins separately revealed pathways associated to metastasis including cell cycle regulation, immune response, and epithelial-to-mesenchymal-transition. However, no common significant pathway was found at both genomic and proteomic levels between the two metastatic models, suggesting a very different biological nature of the cell lines. To address this issue, we used a topological significance analysis based on a “shortest-path” algorithm to identify topological nodes, which uncovered additional biological information with respect to the genomic and glycoproteomic profiles but remained hidden from the direct analyses. Pathway analysis of the significant topological nodes revealed a striking concordance between the models and identified significant common pathways, including “Cytoskeleton remodeling/TGF/WNT”, “Cytoskeleton remodeling/Cytoskeleton remodeling”, and “Cell adhesion/Chemokines and adhesion”. Of these, the “Cytoskeleton remodeling/TGF/WNT” was the top ranked common pathway from the topological analysis of the genomic and proteomic profiles in the two metastatic models. The up-regulation of proteins in the “Cytoskeleton remodeling/TGF/WNT” pathway in the Sa

  10. Sequence similarity network reveals common ancestry of multidomain proteins.

    Science.gov (United States)

    Song, Nan; Joseph, Jacob M; Davis, George B; Durand, Dannie

    2008-05-16

    We address the problem of homology identification in complex multidomain families with varied domain architectures. The challenge is to distinguish sequence pairs that share common ancestry from pairs that share an inserted domain but are otherwise unrelated. This distinction is essential for accuracy in gene annotation, function prediction, and comparative genomics. There are two major obstacles to multidomain homology identification: lack of a formal definition and lack of curated benchmarks for evaluating the performance of new methods. We offer preliminary solutions to both problems: 1) an extension of the traditional model of homology to include domain insertions; and 2) a manually curated benchmark of well-studied families in mouse and human. We further present Neighborhood Correlation, a novel method that exploits the local structure of the sequence similarity network to identify homologs with great accuracy based on the observation that gene duplication and domain shuffling leave distinct patterns in the sequence similarity network. In a rigorous, empirical comparison using our curated data, Neighborhood Correlation outperforms sequence similarity, alignment length, and domain architecture comparison. Neighborhood Correlation is well suited for automated, genome-scale analyses. It is easy to compute, does not require explicit knowledge of domain architecture, and classifies both single and multidomain homologs with high accuracy. Homolog predictions obtained with our method, as well as our manually curated benchmark and a web-based visualization tool for exploratory analysis of the network neighborhood structure, are available at http://www.neighborhoodcorrelation.org. Our work represents a departure from the prevailing view that the concept of homology cannot be applied to genes that have undergone domain shuffling. In contrast to current approaches that either focus on the homology of individual domains or consider only families with identical domain

  11. Sequence similarity network reveals common ancestry of multidomain proteins.

    Directory of Open Access Journals (Sweden)

    Nan Song

    2008-05-01

    Full Text Available We address the problem of homology identification in complex multidomain families with varied domain architectures. The challenge is to distinguish sequence pairs that share common ancestry from pairs that share an inserted domain but are otherwise unrelated. This distinction is essential for accuracy in gene annotation, function prediction, and comparative genomics. There are two major obstacles to multidomain homology identification: lack of a formal definition and lack of curated benchmarks for evaluating the performance of new methods. We offer preliminary solutions to both problems: 1 an extension of the traditional model of homology to include domain insertions; and 2 a manually curated benchmark of well-studied families in mouse and human. We further present Neighborhood Correlation, a novel method that exploits the local structure of the sequence similarity network to identify homologs with great accuracy based on the observation that gene duplication and domain shuffling leave distinct patterns in the sequence similarity network. In a rigorous, empirical comparison using our curated data, Neighborhood Correlation outperforms sequence similarity, alignment length, and domain architecture comparison. Neighborhood Correlation is well suited for automated, genome-scale analyses. It is easy to compute, does not require explicit knowledge of domain architecture, and classifies both single and multidomain homologs with high accuracy. Homolog predictions obtained with our method, as well as our manually curated benchmark and a web-based visualization tool for exploratory analysis of the network neighborhood structure, are available at http://www.neighborhoodcorrelation.org. Our work represents a departure from the prevailing view that the concept of homology cannot be applied to genes that have undergone domain shuffling. In contrast to current approaches that either focus on the homology of individual domains or consider only families with

  12. Comparative Frictional Analysis of Automobile Drum and Disc Brakes

    Directory of Open Access Journals (Sweden)

    H.P. Khairnar

    2016-03-01

    Full Text Available In the present work, a comparative frictional behaviour of drum brakes and disc brakes in automobiles has been investigated. The influential factors; contact force and friction radius were modeled for the estimation of the friction coefficient for drum as well as disc brakes. The effect of contact force and friction radius is studied with varying conditions of parameters; longitudinal force, caliper force and torque on piston side as well as non-piston side. The numerical results obtained have been compared with the similar obtained from virtual Matlab/Simulink models for drum and disc brakes. The results evidenced that friction radius predominantly affects brake pressure and thus the friction coefficient, also the increase in contact force resulted with decrease in friction coefficient both for drum and disc brakes. Further it has been found that disc brakes exhibit gradual decrease of friction coefficient due to the equitable distribution of braking effort while drum brake presents sudden variations in friction coefficient. It can be revealed that frictional behaviour of disc brake is more consistent than drum brake.

  13. Simulating Lahars Using A Rotating Drum

    Science.gov (United States)

    Neather, Adam; Lube, Gert; Jones, Jim; Cronin, Shane

    2014-05-01

    A large (0.5 m in diameter, 0.15 m wide) rotating drum is used to investigate the erosion and deposition mechanics of lahars. To systematically simulate the conditions occurring in natural mass flows our experimental setup differs from the common rotating drum employed in industrial/engineering studies. Natural materials with their typical friction properties are used, as opposed to the frequently employed spherical glass beads; the drum is completely water-proof, so solid/air and solid/liquid mixtures can be investigated; the drum velocity and acceleration can be precisely controlled using a software interface to a micro-controller, allowing for the study of steady, unsteady and intermediate flow regimes. The drum has a toughened glass door, allowing high-resolution, high-speed video recording of the material inside. Vector maps of the velocities involved in the flows are obtained using particle image velocimetry (PIV). The changes in velocity direction and/or magnitude are used to locate the primary internal boundaries between layers of opposite flow direction, as well as secondary interfaces between shear layers. A range of variables can be measured: thickness and number of layers; the curvature of the free surface; frequency of avalanching; position of the centre of mass of the material; and the velocity profiles of the flowing material. Experiments to date have focussed on dry materials, and have had a fill factor of approximately 0.3. Combining these measured variables allows us to derive additional data of interest, such as mass and momentum flux. It is these fluxes that we propose will allow insight into the erosion/deposition mechanics of a lahar. A number of conclusions can be drawn to date. A primary interface separates flowing and passive region (this interface has been identified in previous studies). As well as the primary interface, the flowing layer separates into individual shear layers, with individual erosion/deposition and flow histories. This

  14. An excursion on Linneaeus's drum from Sorsele

    Directory of Open Access Journals (Sweden)

    Bo Lundmark

    1991-01-01

    Full Text Available When Linnaeus made his journey to Holland in 1735, a Saami drum was included in his baggage. The original owner of the drum was the Saami, Anders Nilsson Pont of Granbyn, who was denounced for the possession and use of drums. In this way Linnaeus received greetings from Lycksele lappmark, where he had never set foot. The most likely explanation is that Linnaeus got the drum from Georg Wallin the younger, who made a visit of inspection in 1715.

  15. Study on mechanics of driving drum with superelastic convexity surface covering-layer structure

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, L.J.; Sui, X.H.; Miao, D.J. [Shandong University of Science & Technology, Qingdao (China)

    2008-09-15

    Belt conveyor is one of the main transport equipment in coal mine and the driving drum is its key part. With the method of bionic design, the mushroom morphological structure is applied to the design of covering-layer structure of driving drum surface of belt conveyor. Superelastic rubber with large deformation is adopted as the covering-layer material. Nonlinear constitutive model of rubber, which is of superelasticity and large deformation, is established. The stress states and deformation principles of driving drums including both bionic covering-layer and common covering-layer are obtained by static intensity analysis with Finite Element Analysis (FEA) software ANSYS. The values of the stress and strain on the driving drum surface are gotten and the dangerous area is determined. FEA results show that the superelastic convexity surface structure can enlarge the contact area between the driving drum and viscoelastic belt. The results also show that in comparison with common driving drum, the bionic surface driving drum can not only increase the friction coefficient between drum and belt but also prolong its service life.

  16. ON OPTIMUM DESIGN OF THE SHEARER DRUM

    Institute of Scientific and Technical Information of China (English)

    TaoChidong; ChenChong

    1996-01-01

    On the basis of the model experiments, a software for optimum design of the shearer drum has been developed, and the main parameters of a shearer drum also have been optimized. The combination of the techniques of optimization with the model experiment makes the designing and theoretical systems of the shearer drum more perfect.

  17. Sound Intensity of a Drum

    Directory of Open Access Journals (Sweden)

    Ticha Sethapakdi

    2012-01-01

    Full Text Available A small steel ball was dropped onto the center of a bongo drum. The relationship between impact energy and the maximum amplitude of the sound produced upon impact was determined using release heights ranging from 5 to 70 cm. It was found that there was a power relation between the impact energy and the maximum amplitude of the sound, indicating that the partitioning of energy in the system is dependent on impact energy.

  18. Complex Event Extraction using DRUM

    Science.gov (United States)

    2015-10-01

    read papers and combine results of individual studies into a comprehensive explanatory model. A first step is to automatically extract relevant events...for public release; distribution is unlimited. Complex Event Extraction using DRUM The views, opinions and/or findings contained in this report are...event extraction , big mechanism, deep reading REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 10. SPONSOR/MONITOR’S ACRONYM(S

  19. The coke drum thermal kinetic effects

    Energy Technology Data Exchange (ETDEWEB)

    Aldescu, Maria M.; Romero, Sim; Larson, Mel [KBC Advanced Technologies plc, Surrey (United Kingdom)

    2012-07-01

    The coke drum thermal kinetic dynamics fundamentally affect the coker unit yields as well as the coke product properties and unit reliability. In the drum the thermal cracking and polymerization or condensation reactions take place in a semi-batch environment. Understanding the fundamentals of the foaming kinetics that occur in the coke drums is key to avoiding a foam-over that could result in a unit shutdown for several months. Although the most dynamic changes with time occur during drum filling, other dynamics of the coker process will be discussed as well. KBC has contributed towards uncovering and modelling the complexities of heavy oil thermal dynamics. (author)

  20. Fort Drum integrated resource assessment

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, D.R.; Armstrong, P.R.; Brodrick, J.R.; Daellenbach, K.K.; Di Massa, F.V.; Keller, J.M.; Richman, E.E.; Sullivan, G.P.; Wahlstrom, R.R.

    1992-12-01

    The US Army Forces Command (FORSCOM) has tasked the Pacific Northwest Laboratory (PNL) as the lead laboratory supporting the US Department of Energy (DOE) Federal Energy Management Program's mission to identify, evaluate, and assist in acquiring all cost-effective energy projects at Fort Drum. This is a model program PNL is designing for federal customers served by the Niagara Mohawk Power Company. It will identify and evaluate all electric and fossil fuel cost-effective energy projects; develop a schedule at each installation for project acquisition considering project type, size, timing, and capital requirements, as well as energy and dollar savings; and secure 100% of the financing required to implement electric energy efficiency projects from Niagara Mohawk and have Niagara Mohawk procure the necessary contractors to perform detailed audits and install the technologies. This report documents the assessment of baseline energy use at one of Niagara Mohawk's primary federal facilities, the FORSCOM Fort Drum facility located near Watertown, New York. It is a companion report to Volume 1, the Executive Summary, and Volume 3, the Resource Assessment. This analysis examines the characteristics of electric, gas, oil, propane, coal, and purchased thermal capacity use for fiscal year (FY) 1990. It records energy-use intensities for the facilities at Fort Drum by building type and energy end use. It also breaks down building energy consumption by fuel type, energy end use, and building type. A complete energy consumption reconciliation is presented that includes the accounting of all energy use among buildings, utilities, central systems, and applicable losses.

  1. Comparison of Conventional Sprocket Drum and Sprocket Drum with Modified Design

    Science.gov (United States)

    Sobota, Piotr

    2016-09-01

    Seats in conventional sprocket drums are symmetrical. Due to the set general direction of sprocket drum revolutions resulting from the direction of rock transport, the wear of the seat bottoms and teeth flanks may be reduced by introducing the asymmetry of the profile of the sprocket drum seats. The proposed modification of sprocket drum seats' profile consists of inclining the seat bottom towards the expected direction of the basic drum revolutions. The work compares the loads on the seats and teeth of a conventional drum with its profile conforming to the standard to a modified drum with an asymmetric profile of seats. For the general direction of sprocket drum revolutions, the maximum values of all forces are higher for a standard drum than for a modified drum. The profile asymmetry substantially shortens the friction path of the horizontal link front torus on the seat bottom and relative total friction work on the seat bottom and lessens the occurrence probability of the slide of the horizontal link rear torus on the tooth flank. The modification of the profile causes also the asymmetric wear of link joints. The total relative friction work is considerably reduced in the front joint as compared to a conventional drum, and the total relative friction work in the rear joint is increasing at the same time.

  2. A NOVEL APPROACH TO DRUM VENTING AND DRUM MONITORINGe/pj

    Energy Technology Data Exchange (ETDEWEB)

    Ohl, P.C.; Farwick, C.C.; Douglas, D.G.; Cruz, E.J.

    2003-02-27

    This paper describes the details and specifications associated with drum venting and drum monitoring technologies, and discusses the maturity of in-place systems and current applications. Each year, unventilated drums pressurize and develop bulges and/or breaches that can result in potentially hazardous explosions, posing undesirable hazards to workers and the environment. Drum venting is accomplished by the safe and simple installation of ventilated lids at the time of packaging, or by the inherently risky in-situ ventilation (depressurization) of ''bulged'' drums. Drum monitoring employs either a Magnetically Coupled Pressure Gauge (MCPG) Patent Pending and/or a Magnetically Coupled Corrosion Gauge (MCCG) Patent Pending. Through patented magnetic sensor coupling, these devices enable the noninvasive and remote monitoring of the potentially hazardous materials and/or spent nuclear fuel that is contained in 55-gal drums and associated steel overpack containers.

  3. A NOVEL APPROACH TO DRUM VENTING AND DRUM MONITORINGe/pj

    Energy Technology Data Exchange (ETDEWEB)

    Ohl, P.C.; Farwick, C.C.; Douglas, D.G.; Cruz, E.J.

    2003-02-27

    This paper describes the details and specifications associated with drum venting and drum monitoring technologies, and discusses the maturity of in-place systems and current applications. Each year, unventilated drums pressurize and develop bulges and/or breaches that can result in potentially hazardous explosions, posing undesirable hazards to workers and the environment. Drum venting is accomplished by the safe and simple installation of ventilated lids at the time of packaging, or by the inherently risky in-situ ventilation (depressurization) of ''bulged'' drums. Drum monitoring employs either a Magnetically Coupled Pressure Gauge (MCPG) Patent Pending and/or a Magnetically Coupled Corrosion Gauge (MCCG) Patent Pending. Through patented magnetic sensor coupling, these devices enable the noninvasive and remote monitoring of the potentially hazardous materials and/or spent nuclear fuel that is contained in 55-gal drums and associated steel overpack containers.

  4. Los Alamos waste drum shufflers users manual

    Energy Technology Data Exchange (ETDEWEB)

    Rinard, P.M.; Adams, E.L.; Painter, J.

    1993-08-24

    This user manual describes the Los Alamos waste drum shufflers. The primary purpose of the instruments is to assay the mass of {sup 235}U (or other fissile materials) in drums of assorted waste. It can perform passive assays for isotopes that spontaneously emit neutrons or active assays using the shuffler technique as described on this manual.

  5. ANALYSIS OF DEPOSIT MAINTENANCE IN ROTATING DRUMS

    Directory of Open Access Journals (Sweden)

    Krystian Malek

    2015-10-01

    Full Text Available Rotating drums are used to grinding, drying, mixing, screening, granulating and other processes in environmental engineering. Depending on the nature of the process they can be equipped with additional devices to support the processes. In this work, the effect of drum surface roughness on the behaviour of the feed during drumming. For this purpose, three types of bottom coverings with grain size of 40, 80 and 120 were used. In the experiment the methodology of sequential image analysis using PIV software was applied. The results of theoretical calculations and experimental works have shown significant discrepancies (of approx. 46% of speed characteristics for the minimum speed of the drum and smaller (amounting to approx. 5% for the critical speed. In case of change in the particle size of the drum coverings, there were no significant differences in the behaviour of the feed.

  6. LOAD DISTRIBUTION ON DRUMS OF DOUBLE DRIVE BELT CONVEYOR

    Institute of Scientific and Technical Information of China (English)

    薛河; 苏清祖; 马胜利

    1999-01-01

    The double drum drive is widely used on the mine belt conveyor, which are divided the rigid connected double drums and separately driving double drums according to connected method of two drums. Because of the change of real work condition, the load distribution is changed on the two drive drums, which may produce a slippage between a drum and belt. Slippage may intensify the wear of the drum, and sometimes causing the fire of the belt. This restricts the development toward narrow belt, high velocity and large power of belt conveyor. In this paper, the factors affecting the load distribution of two drums of double drum belt conveyor are'systematically analyzed and some computing formulas derived, by these formulas, the actual load distribution onthe two drums of rigid connected or separately driving belt conveyor can be separately calculated. These formulas also can be as the theory base for adjusting the driving force of two drums.

  7. Lebenszyklus der schamanischen Rahmentrommel - The life cycle of the shamanic frame drum

    Directory of Open Access Journals (Sweden)

    Stefan Festini Cucco

    2012-12-01

    Full Text Available Frame drums are among the most common musical instruments in the world. They are present on every continent -except for Australia- featuring different shapes, sizes, materials and aesthetic qualities. The common denominator of all frame drums across the globe is a drumhead spawn over a frame. For many Euro-Asian peoples the frame drum is an important paraphernalia of the shaman. Rather than as a mere musical instrument, they consider it as a living entity and a constant companion of its owner. As such, the shamans’ drum has a manlike life-cycle or biography: it goes through several lifestages such as conception, birth, initiation, adult life, death and in some cases rebirth. During its lifecycle, the shamans’ drum assumes sundry roles and functions, whereas all of them carry cosmological and mythological meanings. This essay is an attempt to outline a biographical model of the shamans’ drum out of a comparative study, which considers different scholars’ insights in various local traditions of so-called Eurasia.

  8. Study on Parameter Optimization Design of Drum Brake Based on Hybrid Cellular Multiobjective Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    2012-01-01

    Full Text Available In consideration of the significant role the brake plays in ensuring the fast and safe running of vehicles, and since the present parameter optimization design models of brake are far from the practical application, this paper proposes a multiobjective optimization model of drum brake, aiming at maximizing the braking efficiency and minimizing the volume and temperature rise of drum brake. As the commonly used optimization algorithms are of some deficiency, we present a differential evolution cellular multiobjective genetic algorithm (DECell by introducing differential evolution strategy into the canonical cellular genetic algorithm for tackling this problem. For DECell, the gained Pareto front could be as close as possible to the exact Pareto front, and also the diversity of nondominated individuals could be better maintained. The experiments on the test functions reveal that DECell is of good performance in solving high-dimension nonlinear multiobjective problems. And the results of optimizing the new brake model indicate that DECell obviously outperforms the compared popular algorithm NSGA-II concerning the number of obtained brake design parameter sets, the speed, and stability for finding them.

  9. Energy expenditure in rock/pop drumming.

    Science.gov (United States)

    De La Rue, S E; Draper, S B; Potter, C R; Smith, M S

    2013-10-01

    Despite the vigorous nature of rock/pop drumming, there are no precise data on the energy expenditure of this activity. The aim of this study was to quantify the energy cost of rock/pop drumming. Fourteen male drummers (mean±SD; age 27±8 yrs.) completed an incremental drumming test to establish the relationship between energy expenditure and heart rate for this activity and a ramped cycle ergometer test to exhaustion as a criterion measure for peak values (oxygen uptake and heart rate). During live concert performance heart rate was continuously measured and used to estimate energy expenditure (from the energy expenditure vs. heart rate data derived from the drumming test). During concert performance, estimated energy expenditure (mean±SD) was 623±168 kcal.h⁻¹ (8.1±2.2 METs) during performances of 38.6±15.6 min, and drummers achieved a peak heart rate of 186±16 b.min⁻¹. During the drumming test participants attained 78.7±8.3% of the cycle ergometer peak oxygen uptake. Rock/pop drumming represents a relatively high-intensity form of physical activity and as such involves significant energy expenditure. Rock/pop drumming should be considered as a viable alternative to more traditional forms of physical activity.

  10. 49 CFR 178.504 - Standards for steel drums.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for steel drums. 178.504 Section 178.504...-bulk Performance-Oriented Packaging Standards § 178.504 Standards for steel drums. (a) The following are identification codes for steel drums: (1) 1A1 for a non-removable head steel drum; and (2) 1A2...

  11. 30 CFR 56.19026 - Drum end attachment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drum end attachment. 56.19026 Section 56.19026... Ropes § 56.19026 Drum end attachment. (a) For drum end attachment, wire rope shall be attached— (1... bolts, clamps, or wedges, provided that the attachment is a design feature of the hoist drum....

  12. 30 CFR 57.19026 - Drum end attachment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drum end attachment. 57.19026 Section 57.19026... Wire Ropes § 57.19026 Drum end attachment. (a) For drum end attachment, wire rope shall be attached— (1... bolts, clamps, or wedges, provided that the attachment is a design feature of the hoist drum....

  13. TRU drum corrosion task team report

    Energy Technology Data Exchange (ETDEWEB)

    Kooda, K.E.; Lavery, C.A.; Zeek, D.P.

    1996-05-01

    During routine inspections in March 1996, transuranic (TRU) waste drums stored at the Radioactive Waste Management Complex (RWMC) were found with pinholes and leaking fluid. These drums were overpacked, and further inspection discovered over 200 drums with similar corrosion. A task team was assigned to investigate the problem with four specific objectives: to identify any other drums in RWMC TRU storage with pinhole corrosion; to evaluate the adequacy of the RWMC inspection process; to determine the precise mechanism(s) generating the pinhole drum corrosion; and to assess the implications of this event for WIPP certifiability of waste drums. The task team investigations analyzed the source of the pinholes to be Hcl-induced localized pitting corrosion. Hcl formation is directly related to the polychlorinated hydrocarbon volatile organic compounds (VOCs) in the waste. Most of the drums showing pinhole corrosion are from Content Code-003 (CC-003) because they contain the highest amounts of polychlorinated VOCs as determined by headspace gas analysis. CC-001 drums represent the only other content code with a significant number of pinhole corrosion drums because their headspace gas VOC content, although significantly less than CC-003, is far greater than that of the other content codes. The exact mechanisms of Hcl formation could not be determined, but radiolytic and reductive dechlorination and direct reduction of halocarbons were analyzed as the likely operable reactions. The team considered the entire range of feasible options, ranked and prioritized the alternatives, and recommended the optimal solution that maximizes protection of worker and public safety while minimizing impacts on RWMC and TRU program operations.

  14. Comparative transcriptome analysis reveals the genetic basis of skin color variation in common carp.

    Directory of Open Access Journals (Sweden)

    Yanliang Jiang

    Full Text Available The common carp is an important aquaculture species that is widely distributed across the world. During the long history of carp domestication, numerous carp strains with diverse skin colors have been established. Skin color is used as a visual criterion to determine the market value of carp. However, the genetic basis of common carp skin color has not been extensively studied.In this study, we performed Illumina sequencing on two common carp strains: the reddish Xingguo red carp and the brownish-black Yellow River carp. A total of 435,348,868 reads were generated, resulting in 198,781 assembled contigs that were used as reference sequences. Comparisons of skin transcriptome files revealed 2,012 unigenes with significantly different expression in the two common carp strains, including 874 genes that were up-regulated in Xingguo red carp and 1,138 genes that were up-regulated in Yellow River carp. The expression patterns of 20 randomly selected differentially expressed genes were validated using quantitative RT-PCR. Gene pathway analysis of the differentially expressed genes indicated that melanin biosynthesis, along with the Wnt and MAPK signaling pathways, is highly likely to affect the skin pigmentation process. Several key genes involved in the skin pigmentation process, including TYRP1, SILV, ASIP and xCT, showed significant differences in their expression patterns between the two strains.In this study, we conducted a comparative transcriptome analysis of Xingguo red carp and Yellow River carp skins, and we detected key genes involved in the common carp skin pigmentation process. We propose that common carp skin pigmentation depends upon at least three pathways. Understanding fish skin color genetics will facilitate future molecular selection of the fish skin colors with high market values.

  15. Comparative Transcriptome Analysis Reveals the Genetic Basis of Skin Color Variation in Common Carp

    Science.gov (United States)

    Jiang, Yanliang; Zhang, Songhao; Xu, Jian; Feng, Jianxin; Mahboob, Shahid; Al-Ghanim, Khalid A.; Sun, Xiaowen; Xu, Peng

    2014-01-01

    Background The common carp is an important aquaculture species that is widely distributed across the world. During the long history of carp domestication, numerous carp strains with diverse skin colors have been established. Skin color is used as a visual criterion to determine the market value of carp. However, the genetic basis of common carp skin color has not been extensively studied. Methodology/Principal Findings In this study, we performed Illumina sequencing on two common carp strains: the reddish Xingguo red carp and the brownish-black Yellow River carp. A total of 435,348,868 reads were generated, resulting in 198,781 assembled contigs that were used as reference sequences. Comparisons of skin transcriptome files revealed 2,012 unigenes with significantly different expression in the two common carp strains, including 874 genes that were up-regulated in Xingguo red carp and 1,138 genes that were up-regulated in Yellow River carp. The expression patterns of 20 randomly selected differentially expressed genes were validated using quantitative RT-PCR. Gene pathway analysis of the differentially expressed genes indicated that melanin biosynthesis, along with the Wnt and MAPK signaling pathways, is highly likely to affect the skin pigmentation process. Several key genes involved in the skin pigmentation process, including TYRP1, SILV, ASIP and xCT, showed significant differences in their expression patterns between the two strains. Conclusions In this study, we conducted a comparative transcriptome analysis of Xingguo red carp and Yellow River carp skins, and we detected key genes involved in the common carp skin pigmentation process. We propose that common carp skin pigmentation depends upon at least three pathways. Understanding fish skin color genetics will facilitate future molecular selection of the fish skin colors with high market values. PMID:25255374

  16. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

    Science.gov (United States)

    Lanktree, Matthew B.; Guo, Yiran; Murtaza, Muhammed; Glessner, Joseph T.; Bailey, Swneke D.; Onland-Moret, N. Charlotte; Lettre, Guillaume; Ongen, Halit; Rajagopalan, Ramakrishnan; Johnson, Toby; Shen, Haiqing; Nelson, Christopher P.; Klopp, Norman; Baumert, Jens; Padmanabhan, Sandosh; Pankratz, Nathan; Pankow, James S.; Shah, Sonia; Taylor, Kira; Barnard, John; Peters, Bas J.; M. Maloney, Cliona; Lobmeyer, Maximilian T.; Stanton, Alice; Zafarmand, M. Hadi; Romaine, Simon P.R.; Mehta, Amar; van Iperen, Erik P.A.; Gong, Yan; Price, Tom S.; Smith, Erin N.; Kim, Cecilia E.; Li, Yun R.; Asselbergs, Folkert W.; Atwood, Larry D.; Bailey, Kristian M.; Bhatt, Deepak; Bauer, Florianne; Behr, Elijah R.; Bhangale, Tushar; Boer, Jolanda M.A.; Boehm, Bernhard O.; Bradfield, Jonathan P.; Brown, Morris; Braund, Peter S.; Burton, Paul R.; Carty, Cara; Chandrupatla, Hareesh R.; Chen, Wei; Connell, John; Dalgeorgou, Chrysoula; Boer, Anthonius de; Drenos, Fotios; Elbers, Clara C.; Fang, James C.; Fox, Caroline S.; Frackelton, Edward C.; Fuchs, Barry; Furlong, Clement E.; Gibson, Quince; Gieger, Christian; Goel, Anuj; Grobbee, Diederik E.; Hastie, Claire; Howard, Philip J.; Huang, Guan-Hua; Johnson, W. Craig; Li, Qing; Kleber, Marcus E.; Klein, Barbara E.K.; Klein, Ronald; Kooperberg, Charles; Ky, Bonnie; LaCroix, Andrea; Lanken, Paul; Lathrop, Mark; Li, Mingyao; Marshall, Vanessa; Melander, Olle; Mentch, Frank D.; J. Meyer, Nuala; Monda, Keri L.; Montpetit, Alexandre; Murugesan, Gurunathan; Nakayama, Karen; Nondahl, Dave; Onipinla, Abiodun; Rafelt, Suzanne; Newhouse, Stephen J.; Otieno, F. George; Patel, Sanjey R.; Putt, Mary E.; Rodriguez, Santiago; Safa, Radwan N.; Sawyer, Douglas B.; Schreiner, Pamela J.; Simpson, Claire; Sivapalaratnam, Suthesh; Srinivasan, Sathanur R.; Suver, Christine; Swergold, Gary; Sweitzer, Nancy K.; Thomas, Kelly A.; Thorand, Barbara; Timpson, Nicholas J.; Tischfield, Sam; Tobin, Martin; Tomaszweski, Maciej; Verschuren, W.M. Monique; Wallace, Chris; Winkelmann, Bernhard; Zhang, Haitao; Zheng, Dongling; Zhang, Li; Zmuda, Joseph M.; Clarke, Robert; Balmforth, Anthony J.; Danesh, John; Day, Ian N.; Schork, Nicholas J.; de Bakker, Paul I.W.; Delles, Christian; Duggan, David; Hingorani, Aroon D.; Hirschhorn, Joel N.; Hofker, Marten H.; Humphries, Steve E.; Kivimaki, Mika; Lawlor, Debbie A.; Kottke-Marchant, Kandice; Mega, Jessica L.; Mitchell, Braxton D.; Morrow, David A.; Palmen, Jutta; Redline, Susan; Shields, Denis C.; Shuldiner, Alan R.; Sleiman, Patrick M.; Smith, George Davey; Farrall, Martin; Jamshidi, Yalda; Christiani, David C.; Casas, Juan P.; Hall, Alistair S.; Doevendans, Pieter A.; D. Christie, Jason; Berenson, Gerald S.; Murray, Sarah S.; Illig, Thomas; Dorn, Gerald W.; Cappola, Thomas P.; Boerwinkle, Eric; Sever, Peter; Rader, Daniel J.; Reilly, Muredach P.; Caulfield, Mark; Talmud, Philippa J.; Topol, Eric; Engert, James C.; Wang, Kai; Dominiczak, Anna; Hamsten, Anders; Curtis, Sean P.; Silverstein, Roy L.; Lange, Leslie A.; Sabatine, Marc S.; Trip, Mieke; Saleheen, Danish; Peden, John F.; Cruickshanks, Karen J.; März, Winfried; O'Connell, Jeffrey R.; Klungel, Olaf H.; Wijmenga, Cisca; Maitland-van der Zee, Anke Hilse; Schadt, Eric E.; Johnson, Julie A.; Jarvik, Gail P.; Papanicolaou, George J.; Grant, Struan F.A.; Munroe, Patricia B.; North, Kari E.; Samani, Nilesh J.; Koenig, Wolfgang; Gaunt, Tom R.; Anand, Sonia S.; van der Schouw, Yvonne T.; Soranzo, Nicole; FitzGerald, Garret A.; Reiner, Alex; Hegele, Robert A.; Hakonarson, Hakon; Keating, Brendan J.

    2011-01-01

    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and uncommon SNPs with adult height in 114,223 individuals from 47 studies and six ethnicities. A total of 64 loci contained a SNP associated with height at array-wide significance (p < 2.4 × 10−6), with 42 loci surpassing the conventional genome-wide significance threshold (p < 5 × 10−8). Common variants with minor allele frequencies greater than 5% were observed to be associated with height in 37 previously reported loci. In individuals of European ancestry, uncommon SNPs in IL11 and SMAD3, which would not be genotyped with the use of standard genome-wide genotyping arrays, were strongly associated with height (p < 3 × 10−11). Conditional analysis within associated regions revealed five additional variants associated with height independent of lead SNPs within the locus, suggesting allelic heterogeneity. Although underpowered to replicate findings from individuals of European ancestry, the direction of effect of associated variants was largely consistent in African American, South Asian, and Hispanic populations. Overall, we show that dense coverage of genes for uncommon SNPs, coupled with large-scale meta-analysis, can successfully identify additional variants associated with a common complex trait. PMID:21194676

  17. Status of Drum Assay System for disposal of Radioactive Waste Drums stored at KAERI

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Won Hyuk; Kwak, Kyung Kil; Hong, Dae Seok; Shin, Ki Baek [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    According to the construction schedule for the final repository at Kyeong-ju in the southeast of Korea, a disposal plan for the radioactive waste drums at KAERI was required. More than 95% of all radionuclides contained in radioactive waste package should be identified for final disposal. To characterize the radioactive waste drums at KAERI, a radioactive waste drum assay facility equipped with a Wide-Range SGS system manufactured by ANTECH has been constructed. According to the acceptance criteria of KORAD and the government, KAERI make thorough preparation of disposal plan. To characterize the radioactive waste drums at KAERI, a radioactive waste drum assay facility equipped with a Wide-Range SGS system manufactured by ANTECH has been constructed. Since then, about 400 drums have been completed gamma radionuclide assay. Co-60 and Cs-137 were major radionuclides of the radioactive waste drums at KAERI. We have a plan to examine radionuclides and activity of a radioactive waste drum and secure reliability of analysis results with cross analysis using drum assay equipment at institute for inspection.

  18. The eigenspectra of Indian musical drums

    CERN Document Server

    Sathej, G

    2008-01-01

    In a family of drums used in the Indian subcontinent, the circular drum head is made of material of non-uniform density. Remarkably, and in contrast to a circular membrane of uniform density, the low eigenmodes of the non-uniform membrane are harmonic. In this work we model the drum head by a non-uniform membrane whose density varies smoothly between two prescribed values. Using a Fourier-Chebyshev spectral collocation method we obtain the eigenmodes and eigenvalues of the drum head. For a suitable choice of parameters, which we find by optimising a cost function, the eigenspectra obtained from our model are in excellent agreement with experimental values. Our model and the numerical method should find application in numerical sound synthesis.

  19. DRUM DRYER FOR DRYING THE PARTICULATE PRODUCTS

    Directory of Open Access Journals (Sweden)

    I. S. Iurova

    2014-01-01

    Full Text Available Summary. For raise effectiveness drying process drum-type installation in which drum the mechanism of creation of various zones providing a necessary temperature and hydrodynamic regime of process of drying in process of product passage on a drum and changes in it of a relationship of various forms of communication of a moisture, and also a process intensification at last stage of drying by creation разряжения in a continuous technological stream of drying is provided is offered. The drum provides formation of a zone of separation of heat-transfer agent by means of the dissector, zones of intensive drying by disposing lobate nozzles in chessboard order with a dividing ring, zones of separation of the completed heat-transfer agent from жома as a result of separator installation in which the elliptic disk having cuts on a straight line from edge to the centre places, with formation of the triangular slot for passage dried pulp and heat-transfer agent, and also zones the final drying by performance of a section of a drum matching to a zone perforated on which length are had spring-loaded lobate nozzles representing the blades connected bow-shaped rod with metal plates, had with outer side of a drum and under the form repeating its contour, thus the bow-shaped rod from the interior of a drum which ends are supplied by springs rest against overhead and bottom persistent screw nuts, and blades and metal plates are installed with possibility of twirl concerning a fastening place on a drum and supplied by reinforcing ribs.

  20. Steam Drum Design for Direct Steam Generation

    OpenAIRE

    Willwerth, Lisa; Müller, Svenja; Krüger, Joachim; Succo, Manuel; Feldhoff, Jan Fabian; Tiedemann, Jörg; Pandian, Juvaraj; Krüger, Dirk; Hennecke, Klaus

    2016-01-01

    For the direct steam generation in solar fields, the recirculation concept has been demonstrated in several installations. Water masses in the solar field vary during transient phases, such as passing clouds. The volume of the steam drum can serve as a buffer during such transients by taking in excess water and providing water storage. The saturated steam mass flow to the superheating section or the consumer can be maintained almost constant during short transients; therefore the steam drum p...

  1. Flower-drum Opera Krom Anhui

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    THE opening scene of anyflower-drum opera is usuallynoisy,colorful and visuallyexciting.The performers make theirentrance in single to the accom-paniment of drums and gongs-with the women standing gracefullyon the shoulders of the men.While the group moves around the stage,singing.the women make patternsin the air by waving silk fans and large.embroidered handkerchiefs intime to the music.

  2. Miao Women Drum Their Way to Fame

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    POPULATIONS of Miao nationality people are mainly distributed throughout Guizhou, Yunnan, Hunan, Sichuan, Hubei and Guangdong provinces and Guangxi Zhuang Autonomous Region with a population of 7,390,000. Their many offshoots still maintain common features.Ancient Chinese books have records of Miao people who lived more than 5,000 years ago. The Miao have created a colorful traditional culture. Miao embroidery, cross-stitch work and batik are well-known. There are as many as 130 styles of Miao traditional dress. Silver adornments, which are popular among Miao women, are exquisitely made. The Miao people are accomplished singers and dancers. Love songs, sung in the antiphonal style and singing while drinking wine show off their musical talents. The lusheng, a reed-pipe, is the most typical Miao musical instrument. The Miao wood drum dance features a free-spirited and bold style.In their long history, the Miao people have developed an impressive literary tradition, handed down orally rather than in writte

  3. Metabolic Demands of Heavy Metal Drumming

    Directory of Open Access Journals (Sweden)

    Bryan Romero

    2016-07-01

    Full Text Available Background: The drum set involves dynamic movement of all four limbs. Motor control studies have been done on drum set playing, yet not much is known about the physiological responses to this activity. Even less is known about heavy metal drumming. Aims: The purpose of this study was to determine metabolic responses and demands of heavy metal drumming. Methods: Five semi-professional male drummers (mean ± SD age = 27.4 ± 2.6 y, height = 177.2 ± 3.8 cm, body mass = 85.1 ± 17.8 kg performed four prescribed and four self-selected heavy metal songs. Oxygen consumption (VO2, minute ventilation (VE and respiratory exchange ratio (RER were measured using a metabolic cart.  Heart rate (HR was measured using a heart rate monitor. VO2max was determined using a graded cycle ergometer test. Results: The results indicated a metabolic cost of 6.3 ± 1.4 METs and heart rate of 145.1 ± 15.7 beats·min-1 (75.4 ± 8.3% of age-predicted HRmax. VO2 peak values reached approximately 90% of the drummer’s VO2max when performing at the fastest speeds. According to these results, heavy metal drumming may be considered vigorous intensity activity (≥ 6.0 METs. The relative VO2max of 40.2 ± 9.5 mL·kg·min-1 leads to an aerobic fitness classification of “average” for adult males. Conclusions: The metabolic demands required during heavy metal drumming meet the American College of Sports Medicine guidelines for the development of health related fitness.  Keywords: Drum set, Exercise physiology, VO2, Music

  4. Utilizing drumming for American Indians/Alaska Natives with substance use disorders: a focus group study.

    Science.gov (United States)

    Dickerson, Daniel; Robichaud, Francis; Teruya, Cheryl; Nagaran, Kathleen; Hser, Yih-Ing

    2012-09-01

    Drumming has been utilized among American Indian/Alaska Native (AI/AN) tribes for centuries to promote healing and self-expression. Drum-Assisted Recovery Therapy for Native Americans (DARTNA), currently under development, is a substance abuse treatment utilizing drumming as a core component. Focus groups were conducted to assist in the development of the DARTNA protocol. Feedback obtained from these focus groups will inform a subsequent pretest of DARTNA and an empirical study analyzing its effectiveness. Three focus groups were conducted among AIs/ANs with substance use disorders (n = 6), substance abuse treatment providers (n = 8), and a community advisory board (n = 4) to solicit feedback prior to a pretest of the DARTNA protocol. Overall, participants indicated that DARTNA could be beneficial for AIs/ANs with substance use disorders. Four overarching conceptual themes emerged across the focus groups: (1) benefits of drumming, (2) importance of a culture-based focus, (3) addressing gender roles in drumming activities, and (4) providing a foundation of common AI/AN traditions. The DARTNA protocol is a potentially beneficial and culturally appropriate substance abuse treatment strategy for AIs/ANs. In order to optimize the potential benefits of a substance abuse treatment protocol utilizing drumming for AIs/ANs, adequate attention to tribal diversity and gender roles is needed. Due to the shortage of substance abuse treatments utilizing traditional healing activities for AIs/ANs, including drumming, results from this study provide an opportunity to develop an intervention that may meet the unique treatment needs of AIs/ANs.

  5. The Saami shamanic drum in Rome

    Directory of Open Access Journals (Sweden)

    Juha Y. Pentikäinen

    1987-01-01

    Full Text Available What is the history of the drum, which once arrived from the Saami area in northernmost Europe to the collections of an Italian museum, L. Pigorini museum? At the moment, it is the only Saami drum the existence of which is certain in Italy. Saami drums were probably popular objects of export in the 17th and 18th centuries. Missionaries and explorers brought dozens of drums from various parts of Lappmark to be sold and shipped to the private collections of noblemen and other interested people all over Continental Europe. Some of these drums later on found their way to the museums, many became lost or are still somewhere, to be traced by future investigations of local museums and private collections. There clearly has been a special interest towards the most northern corner of the European continent in the Mediterranean countries, particularly in Italy. The correspondence and other descriptions bear evidence about shamanism as the most illuminating and appealing manifestation of the ancient culture and religion of the exotic people living behind the circumpolar zone at the edge of the universe.

  6. Muscle biopsies from human muscle diseases with myopathic pathology reveal common alterations in mitochondrial function.

    Science.gov (United States)

    Sunitha, Balaraju; Gayathri, Narayanappa; Kumar, Manish; Keshava Prasad, Thottethodi Subrahmanya; Nalini, Atchayaram; Padmanabhan, Balasundaram; Srinivas Bharath, Muchukunte Mukunda

    2016-07-01

    Muscle diseases are clinically and genetically heterogeneous and manifest as dystrophic, inflammatory and myopathic pathologies, among others. Our previous study on the cardiotoxin mouse model of myodegeneration and inflammation linked muscle pathology with mitochondrial damage and oxidative stress. In this study, we investigated whether human muscle diseases display mitochondrial changes. Muscle biopsies from muscle disease patients, represented by dysferlinopathy (dysfy) (dystrophic pathology; n = 43), polymyositis (PM) (inflammatory pathology; n = 24), and distal myopathy with rimmed vacuoles (DMRV) (distal myopathy; n = 31) were analyzed. Mitochondrial damage (ragged blue and COX-deficient fibers) was revealed in dysfy, PM, and DMRV cases by enzyme histochemistry (SDH and COX-SDH), electron microscopy (vacuolation and altered cristae) and biochemical assays (significantly increased ADP/ATP ratio). Proteomic analysis of muscle mitochondria from all three muscle diseases by isobaric tag for relative and absolute quantitation labeling and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis demonstrated down-regulation of electron transport chain (ETC) complex subunits, assembly factors and Krebs cycle enzymes. Interestingly, 80 of the under-expressed proteins were common among the three pathologies. Assay of ETC and Krebs cycle enzyme activities validated the MS data. Mitochondrial proteins from muscle pathologies also displayed higher tryptophan (Trp) oxidation and the same was corroborated in the cardiotoxin model. Molecular modeling predicted Trp oxidation to alter the local structure of mitochondrial proteins. Our data highlight mitochondrial alterations in muscle pathologies, represented by morphological changes, altered mitochondrial proteome and protein oxidation, thereby establishing the role of mitochondrial damage in human muscle diseases. We investigated whether human muscle diseases display mitochondrial changes. Muscle biopsies

  7. Revealing time-unlocked brain activity from MEG measurements by common waveform estimation.

    Directory of Open Access Journals (Sweden)

    Yusuke Takeda

    Full Text Available Brain activities related to cognitive functions, such as attention, occur with unknown and variable delays after stimulus onsets. Recently, we proposed a method (Common Waveform Estimation, CWE that could extract such brain activities from magnetoencephalography (MEG or electroencephalography (EEG measurements. CWE estimates spatiotemporal MEG/EEG patterns occurring with unknown and variable delays, referred to here as unlocked waveforms, without hypotheses about their shapes. The purpose of this study is to demonstrate the usefulness of CWE for cognitive neuroscience. For this purpose, we show procedures to estimate unlocked waveforms using CWE and to examine their role. We applied CWE to the MEG epochs during Go trials of a visual Go/NoGo task. This revealed unlocked waveforms with interesting properties, specifically large alpha oscillations around the temporal areas. To examine the role of the unlocked waveform, we attempted to estimate the strength of the brain activity of the unlocked waveform in various conditions. We made a spatial filter to extract the component reflecting the brain activity of the unlocked waveform, applied this spatial filter to MEG data under different conditions (a passive viewing, a simple reaction time, and Go/NoGo tasks, and calculated the powers of the extracted components. Comparing the powers across these conditions suggests that the unlocked waveforms may reflect the inhibition of the task-irrelevant activities in the temporal regions while the subject attends to the visual stimulus. Our results demonstrate that CWE is a potential tool for revealing new findings of cognitive brain functions without any hypothesis in advance.

  8. Enhancing mixing of particles by baffles in a rotating drum mixer

    Institute of Scientific and Technical Information of China (English)

    Maoqiang Jiang; Yongzhi Zhao; Gesi Liu; Jinyang Zheng

    2011-01-01

    Baffles with shape of “-” (single baffle), “+” (cross-baffles with four arms) and (baffles with 6 arms)are used to enhance the mixing of particles in a rotating drum mixer. A micro-dynamics study of mixing and segregation of a bi-disperse system of two particle sizes in the rotating drum with these three kinds of baffles is carried out using the discrete element method (DEM). The effect of the baffles on mixing, and the mechanisms of mixing enhancement by the baffles are discussed and analyzed. Simulation results show that in an unbaffled drum mixer, particle convection, particle diffusion, and size segregation of bidisperse particles, all play important roles in the mixing process; whereas size segregation will be largely restrained when the drum mixer has a baffle, regardless of its shape, and the degree of mixing is higher than that in an unbaffled drum mixer. The different mixing characteristics for “-” shaped baffle, “+” baffle,and baffle are revealed by the simulation results. For “+” or “*” style baffles, there is an optimal size of baffles for the mixing of particles, and the optimal mixing efficiency is higher than that for “-” baffle.

  9. Comparative analyses reveal discrepancies among results of commonly used methods for Anopheles gambiaemolecular form identification

    Directory of Open Access Journals (Sweden)

    Pinto João

    2011-08-01

    Full Text Available Abstract Background Anopheles gambiae M and S molecular forms, the major malaria vectors in the Afro-tropical region, are ongoing a process of ecological diversification and adaptive lineage splitting, which is affecting malaria transmission and vector control strategies in West Africa. These two incipient species are defined on the basis of single nucleotide differences in the IGS and ITS regions of multicopy rDNA located on the X-chromosome. A number of PCR and PCR-RFLP approaches based on form-specific SNPs in the IGS region are used for M and S identification. Moreover, a PCR-method to detect the M-specific insertion of a short interspersed transposable element (SINE200 has recently been introduced as an alternative identification approach. However, a large-scale comparative analysis of four widely used PCR or PCR-RFLP genotyping methods for M and S identification was never carried out to evaluate whether they could be used interchangeably, as commonly assumed. Results The genotyping of more than 400 A. gambiae specimens from nine African countries, and the sequencing of the IGS-amplicon of 115 of them, highlighted discrepancies among results obtained by the different approaches due to different kinds of biases, which may result in an overestimation of MS putative hybrids, as follows: i incorrect match of M and S specific primers used in the allele specific-PCR approach; ii presence of polymorphisms in the recognition sequence of restriction enzymes used in the PCR-RFLP approaches; iii incomplete cleavage during the restriction reactions; iv presence of different copy numbers of M and S-specific IGS-arrays in single individuals in areas of secondary contact between the two forms. Conclusions The results reveal that the PCR and PCR-RFLP approaches most commonly utilized to identify A. gambiae M and S forms are not fully interchangeable as usually assumed, and highlight limits of the actual definition of the two molecular forms, which might

  10. 30 CFR 77.1436 - Drum end attachment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drum end attachment. 77.1436 Section 77.1436... Hoisting Wire Ropes § 77.1436 Drum end attachment. (a) For drum end attachment, wire rope shall be attached... anchor bolts, clamps, or wedges, provided that the attachment is a design feature of the hoist...

  11. 30 CFR 75.1436 - Drum end attachment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drum end attachment. 75.1436 Section 75.1436... attachment. (a) For drum end attachment, wire rope shall be attached— (1) Securely by clips after making one... that the attachment is a design feature of the hoist drum. Design feature means either the...

  12. Motion Sickness Induced by Optokinetic Drums

    NARCIS (Netherlands)

    Bos, J.E.; Bles, W.

    2004-01-01

    Motion sickness is not only elicited by certain kinds of self-motion, but also by motion of a visual scene. In case of the latter, optokinetic drums are often used and a visual-vestibular conflict is assumed to cause the sickness. When the rotation axis is Earth vertical however, different studies s

  13. The Great Bronze Drums of Guangxi

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    SINCE ancient times bronzedrums have been loved by thepeople of Guangxi, and the re- sounding beat of drums has echoedacross its beautiful land for over 2,000years.Even now the sound of drumsnever fails to excite people duringfestivals in Zhuang,Yi and Yao vil- lages.

  14. [Nineteenth century physicians against drum perforation].

    Science.gov (United States)

    Kierzek, A

    1995-01-01

    The trials of "organic" closure of drum perforation are described. The achievements of Adam Politzer, Hermann Schwartze, Joseph Gruber are presented. The first who used term "myringoplasty" was Emil Berthold. The "epochal" method of Wasilij Okuniew and achievements of Beniamin Gomperz are also depicted. The scientific activities of Polish otologists: Ludwik Guranowski and Rafai Spira were presented.

  15. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

    NARCIS (Netherlands)

    Lanktree, Matthew B.; Guo, Yiran; Murtaza, Muhammed; Glessner, Joseph T.; Bailey, Swneke D.; Onland-Moret, N. Charlotte; Lettre, Guillaume; Ongen, Halit; Rajagopalan, Ramakrishnan; Johnson, Toby; Shen, Haiqing; Nelson, Christopher P.; Klopp, Norman; Baumert, Jens; Padmanabhan, Sandosh; Pankratz, Nathan; Pankow, James S.; Shah, Sonia; Taylor, Kira; Barnard, John; Peters, Bas J.; Maloney, Cliona M.; Lobmeyer, Maximilian T.; Stanton, Alice; Zafarmand, M. Hadi; Romaine, Simon P. R.; Mehta, Amar; van Iperen, Erik P. A.; Gong, Yan; Price, Tom S.; Smith, Erin N.; Kim, Cecilia E.; Li, Yun R.; Asselbergs, Folkert W.; Atwood, Larry D.; Bailey, Kristian M.; Bhatt, Deepak; Bauer, Florianne; Behr, Elijah R.; Bhangale, Tushar; Boer, Jolanda M. A.; Boehm, Bernhard O.; Bradfield, Jonathan P.; Brown, Morris; Braund, Peter S.; Burton, Paul R.; Carty, Cara; Chandrupatla, Hareesh R.; Chen, Wei; Connell, John; Dalgeorgou, Chrysoula; de Boer, Anthonius; Drenos, Fotios; Elbers, Clara C.; Fang, James C.; Fox, Caroline S.; Frackelton, Edward C.; Fuchs, Barry; Furlong, Clement E.; Gibson, Quince; Gieger, Christian; Goe, Anuj; Grobbee, Diederik E.; Hastie, Claire; Howard, Philip J.; Huang, Guan-Hua; Johnson, W. Craig; Li, Qing; Kleber, Marcus E.; Klein, Barbara E. K.; Klein, Ronald; Kooperberg, Charles; Ky, Bonnie; LaCroix, Andrea; Lanken, Paul; Lathrop, Mark; Li, Mingyao; Marshal, Vanessa; Melander, Olle; Mentch, Frank D.; Meyer, Nuala J.; Monda, Keri L.; Montpetit, Alexandre; Murugesan, Gurunathan; Nakayama, Karen; Nondah, Dave; Onipinla, Abiodun; Rafelt, Suzanne; Newhouse, Stephen J.; Otieno, F. George; Patel, Sanjey R.; Putt, Mary E.; Rodriguez, Santiago; Safa, Radwan N.; Sawyer, Douglas B.; Schreiner, Pamela J.; Simpson, Claire; Sivapalaratnam, Suthesh; Srinivasan, Sathanur R.; Suver, Christine; Swergold, Gary; Sweitzer, Nancy K.; Thomas, Kelly A.; Thorand, Barbara; Timpson, Nicholas J.; Tischfield, Sam; Tobin, Martin; Tomaszweski, Maciej; Verschuren, W. M. Monique; Wallace, Chris; Winkelmann, Bernhard; Zhang, Haitao; Zheng, Dongling; Zhang, Li; Zmuda, Joseph M.; Clarke, Robert; Balmforth, Anthony J.; Danesh, John; Day, Ian N.; Schork, Nicholas J.; de Bakker, Paul I. W.; Delles, Christian; Duggan, David; Hingorani, Aroon D.; Hirschhorn, Joel N.; Hofker, Marten H.; Humphries, Steve E.; Kivimaki, Mika; Lawlor, Debbie A.; Kottke-Marchant, Kandice; Mega, Jessica L.; Mitchell, Braxton D.; Morrow, David A.; Palmen, Jutta; Redline, Susan; Shields, Denis C.; Shuldiner, Alan R.; Sleiman, Patrick M.; Smith, George Davey; Farrall, Martin; Jamshidi, Yalda; Christiani, David C.; Casas, Juan P.; Hall, Alistair S.; Doevendans, Pieter A.; Christie, Jason D.; Berenson, Gerald S.; Murray, Sarah S.; Illig, Thomas; Dorn, Gerald W.; Cappola, Thomas P.; Boerwinkle, Eric; Sever, Peter; Rader, Daniel J.; Reilly, Muredach P.; Caulfield, Mark; Talmud, Philippa J.; Topol, Eric; Engert, James C.; Wang, Kai; Dominiczak, Anna; Hamsten, Anders; Curtis, Sean P.; Silverstein, Roy L.; Lange, Leslie A.; Sabatine, Marc S.; Trip, Mieke; Saleheen, Danish; Peden, John F.; Cruickshanks, Karen J.; Maerz, Winfried; O'Connell, Jeffrey R.; Klungel, Olaf H.; Wijmenga, Cisca; Maitland-van der Zee, Anke Hilse; Schadt, Eric E.; Johnson, Julie A.; Jarvik, Gail P.; Papanicolaou, George J.; Watkins, Hugh; Grant, Struan F. A.; Munroe, Patricia B.; North, Kari E.; Samani, Nilesh J.; Koenig, Wolfgang; Gaunt, Tom R.; Anand, Sonia S.; van der Schouw, Yvonne T.; Kumari, Meena; Soranzo, Nicole; FitzGerald, Garret A.; Reiner, Alex; Hegele, Robert A.; Hakonarson, Hakon; Keating, Brendan J.

    2011-01-01

    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and

  16. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

    NARCIS (Netherlands)

    Lanktree, Matthew B.; Guo, Yiran; Murtaza, Muhammed; Glessner, Joseph T.; Bailey, Swneke D.; Onland-Moret, N. Charlotte; Lettre, Guillaume; Ongen, Halit; Rajagopalan, Ramakrishnan; Johnson, Toby; Shen, Haiqing; Nelson, Christopher P.; Klopp, Norman; Baumert, Jens; Padmanabhan, Sandosh; Pankratz, Nathan; Pankow, James S.; Shah, Sonia; Taylor, Kira; Barnard, John; Peters, Bas J.; Maloney, Cliona M.; Lobmeyer, Maximilian T.; Stanton, Alice; Zafarmand, M. Hadi; Romaine, Simon P. R.; Mehta, Amar; van Iperen, Erik P. A.; Gong, Yan; Price, Tom S.; Smith, Erin N.; Kim, Cecilia E.; Li, Yun R.; Asselbergs, Folkert W.; Atwood, Larry D.; Bailey, Kristian M.; Bhatt, Deepak; Bauer, Florianne; Behr, Elijah R.; Bhangale, Tushar; Boer, Jolanda M. A.; Boehm, Bernhard O.; Bradfield, Jonathan P.; Brown, Morris; Braund, Peter S.; Burton, Paul R.; Carty, Cara; Chandrupatla, Hareesh R.; Chen, Wei; Connell, John; Dalgeorgou, Chrysoula; de Boer, Anthonius; Drenos, Fotios; Elbers, Clara C.; Fang, James C.; Fox, Caroline S.; Frackelton, Edward C.; Fuchs, Barry; Furlong, Clement E.; Gibson, Quince; Gieger, Christian; Goe, Anuj; Grobbee, Diederik E.; Hastie, Claire; Howard, Philip J.; Huang, Guan-Hua; Johnson, W. Craig; Li, Qing; Kleber, Marcus E.; Klein, Barbara E. K.; Klein, Ronald; Kooperberg, Charles; Ky, Bonnie; LaCroix, Andrea; Lanken, Paul; Lathrop, Mark; Li, Mingyao; Marshal, Vanessa; Melander, Olle; Mentch, Frank D.; Meyer, Nuala J.; Monda, Keri L.; Montpetit, Alexandre; Murugesan, Gurunathan; Nakayama, Karen; Nondah, Dave; Onipinla, Abiodun; Rafelt, Suzanne; Newhouse, Stephen J.; Otieno, F. George; Patel, Sanjey R.; Putt, Mary E.; Rodriguez, Santiago; Safa, Radwan N.; Sawyer, Douglas B.; Schreiner, Pamela J.; Simpson, Claire; Sivapalaratnam, Suthesh; Srinivasan, Sathanur R.; Suver, Christine; Swergold, Gary; Sweitzer, Nancy K.; Thomas, Kelly A.; Thorand, Barbara; Timpson, Nicholas J.; Tischfield, Sam; Tobin, Martin; Tomaszweski, Maciej; Verschuren, W. M. Monique; Wallace, Chris; Winkelmann, Bernhard; Zhang, Haitao; Zheng, Dongling; Zhang, Li; Zmuda, Joseph M.; Clarke, Robert; Balmforth, Anthony J.; Danesh, John; Day, Ian N.; Schork, Nicholas J.; de Bakker, Paul I. W.; Delles, Christian; Duggan, David; Hingorani, Aroon D.; Hirschhorn, Joel N.; Hofker, Marten H.; Humphries, Steve E.; Kivimaki, Mika; Lawlor, Debbie A.; Kottke-Marchant, Kandice; Mega, Jessica L.; Mitchell, Braxton D.; Morrow, David A.; Palmen, Jutta; Redline, Susan; Shields, Denis C.; Shuldiner, Alan R.; Sleiman, Patrick M.; Smith, George Davey; Farrall, Martin; Jamshidi, Yalda; Christiani, David C.; Casas, Juan P.; Hall, Alistair S.; Doevendans, Pieter A.; Christie, Jason D.; Berenson, Gerald S.; Murray, Sarah S.; Illig, Thomas; Dorn, Gerald W.; Cappola, Thomas P.; Boerwinkle, Eric; Sever, Peter; Rader, Daniel J.; Reilly, Muredach P.; Caulfield, Mark; Talmud, Philippa J.; Topol, Eric; Engert, James C.; Wang, Kai; Dominiczak, Anna; Hamsten, Anders; Curtis, Sean P.; Silverstein, Roy L.; Lange, Leslie A.; Sabatine, Marc S.; Trip, Mieke; Saleheen, Danish; Peden, John F.; Cruickshanks, Karen J.; Maerz, Winfried; O'Connell, Jeffrey R.; Klungel, Olaf H.; Wijmenga, Cisca; Maitland-van der Zee, Anke Hilse; Schadt, Eric E.; Johnson, Julie A.; Jarvik, Gail P.; Papanicolaou, George J.; Watkins, Hugh; Grant, Struan F. A.; Munroe, Patricia B.; North, Kari E.; Samani, Nilesh J.; Koenig, Wolfgang; Gaunt, Tom R.; Anand, Sonia S.; van der Schouw, Yvonne T.; Kumari, Meena; Soranzo, Nicole; FitzGerald, Garret A.; Reiner, Alex; Hegele, Robert A.; Hakonarson, Hakon; Keating, Brendan J.

    2011-01-01

    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and

  17. Camera traps reveal an apparent mutualism between a common mesocarnivore and an endangered ungulate

    Science.gov (United States)

    Cove, Michael V.; Maurer, Andrew S.; O'Connell, Allan F.

    2017-01-01

    Camera traps are commonly used to study mammal ecology and they occasionally capture previously undocumented species interactions. The key deer (Odocoileus virginianus clavium) is an endangered endemic subspecies of the Florida Keys, where it exists with few predators. We obtained a camera trap sequence of 80 photos in which a key deer interacted with two northern raccoons (Procyon lotor). One of the raccoons groomed the deer’s face for ∼1 min. This interaction is peculiar and appears mutualistic because the deer was not concerned and willingly remained still throughout the physical contact. Although mutualistic relationships between deer and birds are common, we are unaware of any previously documented mesocarnivore-deer mutualisms. Key deer have evolved in the absence of mammalian predators and we hypothesize that they exhibit reduced vigilance or concern when encountering other species because of predator naivety. Key deer and raccoons are commonly associated with humans and urbanization and an alternative hypothesis is that the interactions are a consequence of heightened deer density, causing a greater probability of sustained interactions with the common mesocarnivores.

  18. DEGRADATION EVALUATION OF HEAVY WATER DRUMS AND TANKS

    Energy Technology Data Exchange (ETDEWEB)

    Mickalonis, J.; Vormelker, P.

    2009-07-31

    Heavy water with varying chemistries is currently being stored in over 6700 drums in L- and K-areas and in seven tanks in L-, K-, and C-areas. A detailed evaluation of the potential degradation of the drums and tanks, specific to their design and service conditions, has been performed to support the demonstration of their integrity throughout the desired storage period. The 55-gallon drums are of several designs with Type 304 stainless steel as the material of construction. The tanks have capacities ranging from 8000 to 45600 gallons and are made of Type 304 stainless steel. The drums and tanks were designed and fabricated to national regulations, codes and standards per procurement specifications for the Savannah River Site. The drums have had approximately 25 leakage failures over their 50+ years of use with the last drum failure occurring in 2003. The tanks have experienced no leaks to date. The failures in the drums have occurred principally near the bottom weld, which attaches the bottom to the drum sidewall. Failures have occurred by pitting, crevice and stress corrosion cracking and are attributable, in part, to the presence of chloride ions in the heavy water. Probable degradation mechanisms for the continued storage of heavy water were evaluated that could lead to future failures in the drum or tanks. This evaluation will be used to support establishment of an inspection plan which will include susceptible locations, methods, and frequencies for the drums and tanks to avoid future leakage failures.

  19. Chipping machines: disc and drum energy requirements

    Directory of Open Access Journals (Sweden)

    Alessio Facello

    2013-09-01

    Full Text Available Air pollution and fossil fuel reserves exhaustion are increasing the importance of the biomass-derived products, in particular wood, as source of clean and renewable energy for the production of electricity or steam. In order to improve the global efficiency and the entire production chain, we have to evaluate the energetic aspects linked to the process of transformation, handling and transport of these materials. This paper reports results on a comparison between two chippers of similar size using different cutting technology: disc and drum tool respectively. During trials, fuel consumption, PTO torque and speed, processing time and weight of processed material were recorded. Power demand, fuel consumption, specific energy and productivity were computed. The machine was fed with four different feedstock types (chestnut logs, poplar logs, poplar branches, poplar sawmill residues. 15 repetitions for each combination of feedstock-tool were carried out. The results of this study show that the disc tool requires, depending on the processed material, from 12 to 18% less fuel per unit of material processed than the drum tool, and consequently, from 12 to 16% less specific energy. In particular, the highest difference between tools was found in branches processing whereas the smallest was in poplar logs. Furthermore the results of the investigation indicate, that, in testing conditions, the productivity of drum tool is higher (8% than disc tool.

  20. Size limitation on zebra mussels consumed by freshwater drum may preclude the effectiveness of drum as a biological controller

    Science.gov (United States)

    French, John R. P.; Love, Joy G.

    1995-01-01

    The septa lengths of bivalve shells were used to estimate shell lengths of the largest zebra mussels (Dreissena polymorpha) crushed and consumed by freshwater drum (Aplodinotus grunniens) to determine if size limitation could preclude the effectiveness of drum as a biological controller of the zebra mussel. We examined gut samples of drum (273 to 542 mm long) collected from western Lake Erie in 1991, found the largest mussel (shell length = 21.4 mm) in the 11th largest drum (TL = 405 mm), and observed a reduction of mussel size in larger drum. The lack of a relationship between mussel size and drum size for larger specimens suggests that either drum prefer smaller mussels or the gape between the upper and lower pharyngeal teeth restricts drum feeding to zebra mussels of limited size. Although drum may reduce zebra mussel populations, because of the apparent size limitation of prey it is unlikely that drum would be fully effective as a biological controller; thus, this fish should not be introduced beyond its native range for that purpose.

  1. Screening and Spectral Summing of LANL Empty Waste Drums - 13226

    Energy Technology Data Exchange (ETDEWEB)

    Gruetzmacher, Kathleen M.; Bustos, Roland M.; Ferran, Scott G.; Gallegos, Lucas E. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Lucero, Randy P. [Pajarito Scientific Corporation, Santa Fe, New Mexico 87505 (United States)

    2013-07-01

    Empty 55-gallon drums that formerly held transuranic (TRU) waste (often over-packed in 85- gallon drums) are generated at LANL and require radiological characterization for disposition. These drums are typically measured and analyzed individually using high purity germanium (HPGe) gamma detectors. This approach can be resource and time intensive. For a project requiring several hundred drums to be characterized in a short time frame, an alternative approach was developed. The approach utilizes a combination of field screening and spectral summing that was required to be technically defensible and meet the Nevada Nuclear Security Site (NNSS) Waste Acceptance Criteria (WAC). In the screening phase of the operation, the drums were counted for 300 seconds (compared to 600 seconds for the typical approach) and checked against Low Level (LL)/TRU thresholds established for each drum configuration and detector. Multiple TRU nuclides and multiple gamma rays for each nuclide were evaluated using an automated spreadsheet utility that can process data from up to 42 drums at a time. Screening results were reviewed by an expert analyst to confirm the field LL/TRU determination. The spectral summing analysis technique combines spectral data (channel-by-channel) associated with a group of individual waste containers producing a composite spectrum. The grouped drums must meet specific similarity criteria. Another automated spreadsheet utility was used to spectral sum data from an unlimited number of similar drums grouped together. The composite spectrum represents a virtual combined drum for the group of drums and was analyzed using the SNAP{sup TM}/Radioassay Data Sheet (RDS)/Batch Data Report (BDR) method. The activity results for a composite virtual drum were divided equally amongst the individual drums to generate characterization results for each individual drum in the group. An initial batch of approximately 500 drums were measured and analyzed in less than 2 months in 2011

  2. A Multimodal Data Mining Framework for Revealing Common Sources of Spam Images

    Directory of Open Access Journals (Sweden)

    Chengcui Zhang

    2009-10-01

    Full Text Available This paper proposes a multimodal framework that clusters spam images so that ones from the same spam source/cluster are grouped together. By identifying the common sources of spam images, we can provide evidence in tracking spam gangs. For this purpose, text recognition and visual feature extraction are performed. Subsequently, a two-level clustering method is applied where images with visually similar illustrations are first grouped together. Then the clustering result from the first level is further refined using the textual clues (if applicable contained in spam images. Our experimental results show the effectiveness of the proposed framework.

  3. VOC transport in vented drums containing simulated waste sludge

    Energy Technology Data Exchange (ETDEWEB)

    Liekhus, K.J.; Gresham, G.L.; Rae, C.; Connolly, M.J.

    1994-02-01

    A model is developed to estimate the volatile organic compound (VOC) concentration in the headspace of the innermost layer of confinement in a lab-scale vented waste drum containing simulated waste sludge. The VOC transport model estimates the concentration using the measured VOC concentration beneath the drum lid and model parameters defined or estimated from process knowledge of drum contents and waste drum configuration. Model parameters include the VOC diffusion characteristic across the filter vent, VOC diffusivity in air, size of opening in the drum liner lid, the type and number of layers of polymer bags surrounding the waste, VOC permeability across the polymer, and the permeable surface area of the polymer bags. Comparison of model and experimental results indicates that the model can accurately estimate VOC concentration in the headspace of the innermost layer of confinement. The model may be useful in estimating the VOC concentration in actual waste drums.

  4. The sound picture of the Saami shamanic drum

    Directory of Open Access Journals (Sweden)

    Rolf Kristoffersson

    1991-01-01

    Full Text Available Research on the Saami shamanic drum has mainly concerned the pictorial world of the drumhead. Therefore, studying the sound picture may give new insights into the Saami Shamanic drum. In my study of the Saami drum I have tried to find the answer to two questions: 1 Is it possible to detect the sound pictogram from some of the drums preserved? 2 Are there marks of usage which might indicate what kind of sounds the users preferred? A comparison of the different drums shows that the signs of usage are surprisingly consistent. The drum sounds reach the receptive organs in the human ear in a range of low but strong tones, with low frequencies but high amplitude. This means that more energy is transferred into the nervous system than with various other types of instrumental sounds.

  5. The Saami shaman drums: some reflexions from an archaelogical perspective

    Directory of Open Access Journals (Sweden)

    Inger Zachrisson

    1991-01-01

    Full Text Available The Saami shaman drums from northern Scandinavia can be discussed from many different points of view. For an archaeologist there are other questions of interest than those which generally occupy the historian of religions. One important question is how old the known Saami drums are. The known drums are as a rule assumed to be from the seventeenth or the eighteenth centuries, when most of them were collected. It has also been thought that, because of the materials they are made of, drums could not have been preserved any longer. Another perhaps more interesting question is how old the known types of Saami drums might be. When did they acquire their 'classical' form? What did the Viking Age Saami drums look like?

  6. Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases

    Science.gov (United States)

    Tippana, Ramreddy; Hwang, Helen; Opresko, Patricia L.; Bohr, Vilhelm A.; Myong, Sua

    2016-01-01

    G-quadruplex (GQ) is a four stranded DNA secondary structure that arises from a guanine rich sequence. Stable formation of GQ in genomic DNA can be counteracted by the resolving activity of specialized helicases including RNA helicase AU (associated with AU rich elements) (RHAU) (G4 resolvase 1), Bloom helicase (BLM), and Werner helicase (WRN). However, their substrate specificity and the mechanism involved in GQ unfolding remain uncertain. Here, we report that RHAU, BLM, and WRN exhibit distinct GQ conformation specificity, but use a common mechanism of repetitive unfolding that leads to disrupting GQ structure multiple times in succession. Such unfolding activity of RHAU leads to efficient annealing exclusively within the same DNA molecule. The same resolving activity is sufficient to dislodge a stably bound GQ ligand, including BRACO-19, NMM, and Phen-DC3. Our study demonstrates a plausible biological scheme where different helicases are delegated to resolve specific GQ structures by using a common repetitive unfolding mechanism that provides a robust resolving power. PMID:27407146

  7. Drum-mate: interaction dynamics and gestures in human-humanoid drumming experiments

    Science.gov (United States)

    Kose-Bagci, Hatice; Dautenhahn, Kerstin; Syrdal, Dag S.; Nehaniv, Chrystopher L.

    2010-06-01

    This article investigates the role of interaction kinesics in human-robot interaction (HRI). We adopted a bottom-up, synthetic approach towards interactive competencies in robots using simple, minimal computational models underlying the robot's interaction dynamics. We present two empirical, exploratory studies investigating a drumming experience with a humanoid robot (KASPAR) and a human. In the first experiment, the turn-taking behaviour of the humanoid is deterministic and the non-verbal gestures of the robot accompany its drumming to assess the impact of non-verbal gestures on the interaction. The second experiment studies a computational framework that facilitates emergent turn-taking dynamics, whereby the particular dynamics of turn-taking emerge from the social interaction between the human and the humanoid. The results from the HRI experiments are presented and analysed qualitatively (in terms of the participants' subjective experiences) and quantitatively (concerning the drumming performance of the human-robot pair). The results point out a trade-off between the subjective evaluation of the drumming experience from the perspective of the participants and the objective evaluation of the drumming performance. A certain number of gestures was preferred as a motivational factor in the interaction. The participants preferred the models underlying the robot's turn-taking which enable the robot and human to interact more and provide turn-taking closer to 'natural' human-human conversations, despite differences in objective measures of drumming behaviour. The results are consistent with the temporal behaviour matching hypothesis previously proposed in the literature which concerns the effect that the participants adapt their own interaction dynamics to the robot's.

  8. Safety analysis report for packaging (onsite) steel drum

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, W.A.

    1998-09-29

    This Safety Analysis Report for Packaging (SARP) provides the analyses and evaluations necessary to demonstrate that the steel drum packaging system meets the transportation safety requirements of HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments, for an onsite packaging containing Type B quantities of solid and liquid radioactive materials. The basic component of the steel drum packaging system is the 208 L (55-gal) steel drum.

  9. The synaptic connexions to intercostal motoneurones as revealed by the average common excitation potential.

    Science.gov (United States)

    Kirkwood, P A; Sears, T A

    1978-02-01

    1. The hypothesis is advanced that the joint occurrence of unitary e.p.s.p.s evoked in motoneurones by branches of common stem presynaptic fibres causes, on average, transient depolarization in one motoneurone at the time of discharge in another motoneurone of the same pool. 2. The hypothesis was tested in anaesthetized, paralysed cats by averaging the naturally occurring synpatic noise of thoracic inspiratory motoneurones with an averager triggered by spikes from other inspiratory motoneurones. These spikes were obtained as efferent discharges in nerve filaments supplying the proximal regions of the external intercostal muscles. 3. A transient depolarization centred around the time of the trigger spikes was consistently observed and was designated the average common excitation (a.c.e.) potential. 4. The peak depolarization lay between -1.0 and +4.6 msec (mean +0.7 msec) with respect to the trigger spikes and the rise times of its most prominent component ranged from 4 to 16 msec (mean 8.4 msec). 5. The amplitudes of the a.c.e. potentials ranged from 6 to 104 muV (mean 32 muV) when the trigger spikes were derived from a filament in the same segment as the relevant motoneurones, and from 3 to 42 muV (mean 19 muV) when the filament was two segments rostral to the motoneurone. 6. Cells innervating the proximal region of the intercostal space gave larger a.c.e. potentials than those innervating more distal regions and also showed larger central respiratory drive potentials. 7. A.c.e. potentials were observed for either alpha or gamma spikes as triggers. The potentials were usually smaller for the gamma than for the alpha spikes, the mean ration being about 0.6. The presence of the a.c.e. potentials from the gamma spikes was taken as evidence for alpha-gamma coactivation by common presynaptic axons. 8. A theory is developed which quantitatively accounts for the main features of both the a.c.e. potential and the short term synchrony observed by Sears & Stagg (1976). 9

  10. An economic experiment reveals that humans prefer pool punishment to maintain the commons.

    Science.gov (United States)

    Traulsen, Arne; Röhl, Torsten; Milinski, Manfred

    2012-09-22

    Punishment can stabilize costly cooperation and ensure the success of a common project that is threatened by free-riders. Punishment mechanisms can be classified into pool punishment, where the punishment act is carried out by a paid third party, (e.g. a police system or a sheriff), and peer punishment, where the punishment act is carried out by peers. Which punishment mechanism is preferred when both are concurrently available within a society? In an economic experiment, we show that the majority of subjects choose pool punishment, despite being costly even in the absence of defectors, when second-order free-riders, cooperators that do not punish, are also punished. Pool punishers are mutually enforcing their support for the punishment organization, stably trapping each other. Our experimental results show how organized punishment could have displaced individual punishment in human societies.

  11. Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury.

    Directory of Open Access Journals (Sweden)

    Helen L Hellmich

    Full Text Available Developing new pharmacotherapies for traumatic brain injury (TBI requires elucidation of the neuroprotective mechanisms of many structurally and functionally diverse compounds. To test our hypothesis that diverse neuroprotective drugs similarly affect common gene targets after TBI, we compared the effects of two drugs, metyrapone (MT and carbenoxolone (CB, which, though used clinically for noncognitive conditions, improved learning and memory in rats and humans. Although structurally different, both MT and CB inhibit a common molecular target, 11β hydroxysteroid dehydrogenase type 1, which converts inactive cortisone to cortisol, thereby effectively reducing glucocorticoid levels. We examined injury-induced signaling pathways to determine how the effects of these two compounds correlate with pro-survival effects in surviving neurons of the injured rat hippocampus. We found that treatment of TBI rats with MT or CB acutely induced in hippocampal neurons transcriptional profiles that were remarkably similar (i.e., a coordinated attenuation of gene expression across multiple injury-induced cell signaling networks. We also found, to a lesser extent, a coordinated increase in cell survival signals. Analysis of injury-induced gene expression altered by MT and CB provided additional insight into the protective effects of each. Both drugs attenuated expression of genes in the apoptosis, death receptor and stress signaling pathways, as well as multiple genes in the oxidative phosphorylation pathway such as subunits of NADH dehydrogenase (Complex1, cytochrome c oxidase (Complex IV and ATP synthase (Complex V. This suggests an overall inhibition of mitochondrial function. Complex 1 is the primary source of reactive oxygen species in the mitochondrial oxidative phosphorylation pathway, thus linking the protective effects of these drugs to a reduction in oxidative stress. The net effect of the drug-induced transcriptional changes observed here indicates that

  12. RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming.

    Directory of Open Access Journals (Sweden)

    Helen L Wright

    Full Text Available Neutrophils are central to the pathology of inflammatory diseases, where they can damage host tissue through release of reactive oxygen metabolites and proteases, and drive inflammation via secretion of cytokines and chemokines. Many cytokines, such as those generated during inflammation, can induce a similar "primed" phenotype in neutrophils, but it is unknown if different cytokines utilise common or cytokine-specific pathways to induce these functional changes. Here, we describe the transcriptomic changes induced in control human neutrophils during priming in vitro with pro-inflammatory cytokines (TNF-α and GM-CSF using RNA-seq. Priming led to the rapid expression of a common set of transcripts for cytokines, chemokines and cell surface receptors (CXCL1, CXCL2, IL1A, IL1B, IL1RA, ICAM1. However, 580 genes were differentially regulated by TNF-α and GM-CSF treatment, and of these 58 were directly implicated in the control of apoptosis. While these two cytokines both delayed apoptosis, they induced changes in expression of different pro- and anti-apoptotic genes. Bioinformatics analysis predicted that these genes were regulated via differential activation of transcription factors by TNF-α and GM-CSF and these predictions were confirmed using functional assays: inhibition of NF-κB signalling abrogated the protective effect of TNF-α (but not that of GM-CSF on neutrophil apoptosis, whereas inhibition of JAK/STAT signalling abrogated the anti-apoptotic effect of GM-CSF, but not that of TNF-α (p<0.05. These data provide the first characterisation of the human neutrophil transcriptome following GM-CSF and TNF-α priming, and demonstrate the utility of this approach to define functional changes in neutrophils following cytokine exposure. This may provide an important, new approach to define the molecular properties of neutrophils after in vivo activation during inflammation.

  13. Sound Quality and Striking Position of a Conga Drum

    Directory of Open Access Journals (Sweden)

    Dylan Harvey

    2014-12-01

    Full Text Available The relationship between the location at which a drum membrane was struck and the quality of sound produced was investigated by striking the drum at several distances between the center and the rim. Through analyzing the harmonics of the wave produced from the impact, it was shown that as the striking location changes, the relative amplitudes of different modes of vibration also changes. It was found that sound of a higher pitch is produced at the rim of the drum than anywhere else on the drum head due to higher modes of vibration becoming dominant.

  14. Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

    Energy Technology Data Exchange (ETDEWEB)

    Sadre-Bazzaz, K.; Robinson, H.; Whitby, F. G.; Formosa, T.; Hill, C. P.

    2010-03-12

    The proteasome is an abundant protease that is critically important for numerous cellular pathways. Proteasomes are activated in vitro by three known classes of proteins/complexes, including Blm10/PA200. Here, we report a 3.4 {angstrom} resolution crystal structure of a proteasome-Blm10 complex, which reveals that Blm10 surrounds the proteasome entry pore in the 1.2 MDa complex to form a largely closed dome that is expected to restrict access of potential substrates. This architecture and the observation that Blm10 induces a disordered proteasome gate structure challenge the assumption that Blm10 functions as an activator of proteolysis in vivo. The Blm10 C terminus binds in the same manner as seen for 11S activators and inferred for 19S/PAN activators and indicates a unified model for gate opening. We also demonstrate that Blm10 acts to maintain mitochondrial function. Consistent with the structural data, the C-terminal residues of Blm10 are needed for this activity.

  15. Patterns of hypothalamic regionalization in amphibians and reptiles: common traits revealed by a genoarchitectonic approach

    Directory of Open Access Journals (Sweden)

    Laura eDominguez

    2015-02-01

    Full Text Available Most studies in mammals and birds have demonstrated common patterns of hypothalamic development highlighted by the combination of developmental regulatory genes (genoarchitecture, supporting the notion of the hypothalamus as a component of the secondary prosencephalon, topologically rostral to the diencephalon. In our comparative analysis we have summarized the data on the expression patterns of different transcription factors and neuroactive substances, used as anatomical markers, in the developing hypothalamus of the amphibian Xenopus laevis and the juvenile turtle Pseudemys scripta. This analysis served to highlight the organization of the hypothalamus in the anamniote/amniotic transition. We have identified supraoptoparaventricular and the suprachiasmatic regions in the alar part of the hypothalamus, and tuberal and mammillary regions in the basal hypothalamus. Shared features in the two species are: 1 The supraoptoparaventricular region is defined by the expression of Otp and the lack of Nkx2.1/Isl1. It is subdivided into rostral, rich in Otp and Nkx2.2, and caudal, only Otp-positive, portions. 2 The suprachiasmatic area contains catecholaminergic cell groups and lacks Otp, and can be further divided into rostral (rich in Nkx2.1 and Nkx2.2 and a caudal (rich in Isl1 and devoid of Nkx2.1 portions. 3 Expression of Nkx2.1 and Isl1 define the tuberal hypothalamus and only the rostral portion expresses Otp. 4 Its caudal boundary is evident by the lack of Isl1 in the adjacent mammillary region, which expresses Nkx2.1 and Otp. Differences in the anamnio-amniote transition were noted since in the turtle, like in other amniotes, the boundary between the alar hypothalamus and the telencephalic preoptic area shows distinct Nkx2.2 and Otp expressions but not in the amphibian (anamniote, and the alar supraoptoparaventricular region is defined by the expression of Otp/Pax6, whereas in Xenopus only Otp is expressed.

  16. Proteome profiling reveals regional protein alteration in cerebrum of common marmoset (Callithrix jacchus) exposed to methylmercury.

    Science.gov (United States)

    Shao, Yueting; Yamamoto, Megumi; Figeys, Daniel; Ning, Zhibin; Chan, Hing Man

    2016-03-10

    Methylmercury (MeHg) is known to selectively damage the calcarine and precentral cortices along deep sulci and fissures in adult cases, but the detailed mechanism is still unclear. This study aims to identify and analyze the differential proteome expression in two regions of the cerebrum (the frontal lobe and the occipital lobe including the calcarine sulcus) of the common marmoset exposed to MeHg using a shot-gun proteomic approach. A total of 1045 and 1062 proteins were identified in the frontal lobe (FL) and occipital lobe (OL), of which, 62 and 89 proteins were found significantly changed with MeHg exposure. Functional enrichment/depletion analysis showed that the lipid metabolic process and proteolysis were affected in both two lobes. Functional changes in FL were characterized in cell cycle and cell division, sulfur compound metabolic process, microtubule-based process and glycerolipid metabolic process. In comparison, proteins were enriched in the functions of transport, carbohydrate metabolic process, chemical caused homeostasis and regulation of body fluid levels in OL. Pathway analysis predicted that vasopressin-regulated water reabsorption was disturbed in MeHg-treated FL. Our results showed that MeHg induced regional specific protein changes in FL and OL but with similar endpoint effects such as energy diminish and disruption of water transport. APOE and GPX1 were shown to be possible key proteins targeted by MeHg leading to multiple functional changes in OL. This is the first report of the whole proteome changes of primate cerebrum for MeHg neurotoxicity, and the results will contribute to the understanding of molecular basis of MeHg intoxication in humans. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. Patterns of hypothalamic regionalization in amphibians and reptiles: common traits revealed by a genoarchitectonic approach.

    Science.gov (United States)

    Domínguez, Laura; González, Agustín; Moreno, Nerea

    2015-01-01

    Most studies in mammals and birds have demonstrated common patterns of hypothalamic development highlighted by the combination of developmental regulatory genes (genoarchitecture), supporting the notion of the hypothalamus as a component of the secondary prosencephalon, topologically rostral to the diencephalon. In our comparative analysis we have summarized the data on the expression patterns of different transcription factors and neuroactive substances, used as anatomical markers, in the developing hypothalamus of the amphibian Xenopus laevis and the juvenile turtle Pseudemys scripta. This analysis served to highlight the organization of the hypothalamus in the anamniote/amniotic transition. We have identified supraoptoparaventricular and the suprachiasmatic regions (SCs) in the alar part of the hypothalamus, and tuberal and mammillary regions in the basal hypothalamus. Shared features in the two species are: (1) The supraoptoparaventricular region (SPV) is defined by the expression of Otp and the lack of Nkx2.1/Isl1. It is subdivided into rostral, rich in Otp and Nkx2.2, and caudal, only Otp-positive, portions. (2) The suprachiasmatic area contains catecholaminergic cell groups and lacks Otp, and can be further divided into rostral (rich in Nkx2.1 and Nkx2.2) and a caudal (rich in Isl1 and devoid of Nkx2.1) portions. (3) Expression of Nkx2.1 and Isl1 define the tuberal hypothalamus and only the rostral portion expresses Otp. (4) Its caudal boundary is evident by the lack of Isl1 in the adjacent mammillary region, which expresses Nkx2.1 and Otp. Differences in the anamnio-amniote transition were noted since in the turtle, like in other amniotes, the boundary between the alar hypothalamus and the telencephalic preoptic area shows distinct Nkx2.2 and Otp expressions but not in the amphibian (anamniote), and the alar SPV is defined by the expression of Otp/Pax6, whereas in Xenopus only Otp is expressed.

  18. A survey of genomic traces reveals a common sequencing error, RNA editing, and DNA editing.

    Directory of Open Access Journals (Sweden)

    Alexander Wait Zaranek

    2010-05-01

    Full Text Available While it is widely held that an organism's genomic information should remain constant, several protein families are known to modify it. Members of the AID/APOBEC protein family can deaminate DNA. Similarly, members of the ADAR family can deaminate RNA. Characterizing the scope of these events is challenging. Here we use large genomic data sets, such as the two billion sequences in the NCBI Trace Archive, to look for clusters of mismatches of the same type, which are a hallmark of editing events caused by APOBEC3 and ADAR. We align 603,249,815 traces from the NCBI trace archive to their reference genomes. In clusters of mismatches of increasing size, at least one systematic sequencing error dominates the results (G-to-A. It is still present in mismatches with 99% accuracy and only vanishes in mismatches at 99.99% accuracy or higher. The error appears to have entered into about 1% of the HapMap, possibly affecting other users that rely on this resource. Further investigation, using stringent quality thresholds, uncovers thousands of mismatch clusters with no apparent defects in their chromatograms. These traces provide the first reported candidates of endogenous DNA editing in human, further elucidating RNA editing in human and mouse and also revealing, for the first time, extensive RNA editing in Xenopus tropicalis. We show that the NCBI Trace Archive provides a valuable resource for the investigation of the phenomena of DNA and RNA editing, as well as setting the stage for a comprehensive mapping of editing events in large-scale genomic datasets.

  19. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation

    OpenAIRE

    Yurtsever, Zeynep; Scheaffer, Suzanne M.; Romero, Arthur G.; Holtzman, Michael J.; Brett, Tom J.

    2015-01-01

    The p38 MAP kinases are an important family of drug targets for a myriad of inflammatory, as well as other, diseases. Presented here is the crystal structure of the active form of MAPK13 (p38d) as well as a comprehensive analysis of all known apo inactive and active p38 MAPK structures, revealing a common mode of activation as well as some unique structural features.

  20. Mechanical Modeling of a WIPP Drum Under Pressure

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Jeffrey A. [Sandia National Laboratories, Albuquerque, NM (United States)

    2014-11-25

    Mechanical modeling was undertaken to support the Waste Isolation Pilot Plant (WIPP) technical assessment team (TAT) investigating the February 14th 2014 event where there was a radiological release at the WIPP. The initial goal of the modeling was to examine if a mechanical model could inform the team about the event. The intention was to have a model that could test scenarios with respect to the rate of pressurization. It was expected that the deformation and failure (inability of the drum to contain any pressure) would vary according to the pressurization rate. As the work progressed there was also interest in using the mechanical analysis of the drum to investigate what would happen if a drum pressurized when it was located under a standard waste package. Specifically, would the deformation be detectable from camera views within the room. A finite element model of a WIPP 55-gallon drum was developed that used all hex elements. Analyses were conducted using the explicit transient dynamics module of Sierra/SM to explore potential pressurization scenarios of the drum. Theses analysis show similar deformation patterns to documented pressurization tests of drums in the literature. The calculated failure pressures from previous tests documented in the literature vary from as little as 16 psi to 320 psi. In addition, previous testing documented in the literature shows drums bulging but not failing at pressures ranging from 69 to 138 psi. The analyses performed for this study found the drums failing at pressures ranging from 35 psi to 75 psi. When the drums are pressurized quickly (in 0.01 seconds) there is significant deformation to the lid. At lower pressurization rates the deformation of the lid is considerably less, yet the lids will still open from the pressure. The analyses demonstrate the influence of pressurization rate on deformation and opening pressure of the drums. Analyses conducted with a substantial mass on top of the closed drum demonstrate that the

  1. Cookoff Modeling of a WIPP waste drum (68660)

    Energy Technology Data Exchange (ETDEWEB)

    Hobbs, Michael L. [Sandia National Laboratories, Albuquerque, NM (United States)

    2014-11-24

    A waste drum located 2150 feet underground may have been the root cause of a radiation leak on February 14, 2014. Information provided to the WIPP Technical Assessment Team (TAT) was used to describe the approximate content of the drum, which included an organic cat litter (Swheat Scoop®, or Swheat) composed of 100% wheat products. The drum also contained various nitrate salts, oxalic acid, and a nitric acid solution that was neutralized with triethanolamine (TEA). CTH-TIGER was used with the approximate drum contents to specify the products for an exothermic reaction for the drum. If an inorganic adsorbent such as zeolite had been used in lieu of the kitty litter, the overall reaction would have been endothermic. Dilution with a zeolite adsorbent might be a useful method to remediate drums containing organic kitty litter. SIERRA THERMAL was used to calculate the pressurization and ignition of the drum. A baseline simulation of drum 68660 was performed by assuming a background heat source of 0.5-10 W of unknown origin. The 0.5 W source could be representative of heat generated by radioactive decay. The drum ignited after about 70 days. Gas generation at ignition was predicted to be 300-500 psig with a sealed drum (no vent). At ignition, the wall temperature increases modestly by about 1°C, demonstrating that heating would not be apparent prior to ignition. The ignition location was predicted to be about 0.43 meters above the bottom center portion of the drum. At ignition only 3-5 kg (out of 71.6 kg total) has been converted into gas, indicating that most of the material remained available for post-ignition reaction.

  2. Chimpanzee drumming : a spontaneous performance with characteristics of human musical drumming

    NARCIS (Netherlands)

    Dufour, Valerie; Poulin, Nicolas; Cure, Charlotte; Sterck, Elisabeth H. M.

    2015-01-01

    Despite the quintessential role that music plays in human societies by enabling us to release and share emotions with others, traces of its evolutionary origins in other species remain scarce. Drumming like humans whilst producing music is practically unheard of in our most closely related species,

  3. Multiloop control of a drum boiler

    Directory of Open Access Journals (Sweden)

    Alena Kozáková

    2014-05-01

    Full Text Available The Equivalent Subsystems Method (ESM (Kozáková et al., 2011 is methodology of decentralized controller design in the frequency domain which allows designing local controllers using any SISO frequency domain method. The paper deals with the digital ESM version where digital local PID controllers guaranteeing required performance for the full system are designed for individual equivalent subsystems using the practice-oriented Sine-wave method (Bucz et al., 2012. The proposed decentralized controller design procedure was verified on the nonlinear benchmark drum boiler simulation model (Morilla, 2012.

  4. Packaging design criteria for the Type B Drum

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, W.S.; Smith, R.J.; Wells, A.H.

    1995-09-01

    The Type B Drum package is a transportation cask capable of shipping a single 55-gal (208 L) drum of transuranic (TRU) waste. The Type B Drum is smaller than existing certified packages, such as the TRUPACT-II cask, but will allow payloads with higher thermal and gas generation rates, thus providing greater operational flexibility. The Type B Drum package has double containment so that plutonium contents and other radioactive material may be transported in Type B quantities. Conceptual designs of unshielded and shielded versions of the Type B Drum were completed in Report on the Conceptual Design of the Unshielded Type B Drum Packaging and Report on the Conceptual Design of the Shielded type B Drum Packaging (WEC 1994a, WEC 1994b), which demonstrated the Type B Drum to be a viable packaging system. A Type B package containment system must withstand the normal conditions of transport and the hypothetical accident conditions, which include a 9-m (30-ft) drop onto an unyielding surface and a 1-m (3-ft) drop onto a 15-cm (6-in.) diameter pin, and a fire and immersion scenarios.

  5. Self-diffusion of wet particles in rotating drums

    Science.gov (United States)

    Liu, P. Y.; Yang, R. Y.; Yu, A. B.

    2013-06-01

    Axial mixing of wet particles in rotating drums was investigated by the discrete element method with the capillary force explicitly considered. Different flow regimes were observed by varying the surface tension of liquid and keeping other conditions unchanged. The analysis of the concentration and mean square displacement of particles indicated that the axial motion of wet particles was a diffusive process characterised by Fick's law. Particle diffusivity decreased with increasing inter-particle cohesion and drum filling level but increased with increasing drum rotation speed. Two competing mechanisms were proposed to explain these effects. A theoretical model based on the relation between local diffusivity and shear rate was developed to predict particle diffusivity as a function of drum operation conditions. It was also observed that despite the high inhomogeneity of particle flow in rotating drums, the mean diffusivity of flow exhibited a strong correlation with granular temperature, defined as the mean square fluctuating velocity of particles.

  6. Perfomance investigation of thresher T30 at threshing some common wheat varieties

    Directory of Open Access Journals (Sweden)

    E Askari Asli–Ardeh

    2016-04-01

    Full Text Available Introduction: In many rural areas, manual threshers are still in use because of the small farming units. However, research sections, have been used manual threshers particularly in breeding unites in many cases due to the low volume of crop. Manual threshers for the first time were manufactured by Iran Ashtad Cooperative in two models (T25 and T30 and then they were made available to the farmers across the country. The threshers due to having wire loop drum had a good performance for threshing rice crop. According to the mentioned application, manual threshers expected to have been capable of threshing wheat crop. A type of this thresher (modelT30 was available in University of Mohaghegh Ardabili. Therefore, It was decided that the performance of this thresher was assessed at threshing some common wheat varieties in Ardabil province. Effects of drum speed levels (800, 900 and 1000 rpm of threshing unit of john deere combine (model 955 on damaged grains percent showed that the minimum of this dependent factor was obtained at two levels of drum speed 800 and 900 rpm, clearance between drum and concave 25 mm and forward speed 1.8 km.h-1 (Lashgari et al., 2008. Research performed by Vejasit and Salokhe (2004 on a axial flow thresher revealed that the threshing efficiency can be 98 to 100% at tests for soybean, drum speed 600 to 700 rpm, feed rate 540 to 720 kg h-1 and grain moisture content 14.34 to 22.77 w.b.%. Alizadeh and Khodabakhshipour (2010 found at moisture content 17 to 23 w.b.% and drum speed 450 to 850 rpm at test of an axial flow thresher on paddy, ,the most damaged grains percent obtained at the most level of drum speed 850 rpm and the least level grain moisture content 17 W.b.%. Threshing losses due to mechanical damaged wheat grains during threshing process were reported 5.0, 8.1, 10.0 and 19.9% at tests at drum speed 800, 900, 1000 and 1100 rpm, respectively, by King and Riddols (1962. The results of research reported by Mitchell and

  7. 49 CFR 178.506 - Standards for metal drums other than steel or aluminum.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for metal drums other than steel or... drums other than steel or aluminum. (a) The following are the identification codes for metal drums other than steel or aluminum: (1) 1N1 for a non-removable head metal drum; and (2) 1N2 for a removable...

  8. Genetic diversity revealed by genomic-SSR and EST-SSR markers among common wheat, spelt and compactum

    Institute of Scientific and Technical Information of China (English)

    YANG Xinquan; LIU Peng; HAN Zongfu; NI Zhongfu; SUN Qixin

    2005-01-01

    In this study, two SSR molecular markers, named genomic-SSR and EST-SSR, are used to measure the genetic diversity among three hexaploid wheat populations, which include 28 common wheat ( Triticum aestivum L. ), 13 spelt ( Triticum spelta L. ),and 11 compactum ( Triticum compactum Host. ). The results show that common wheat has the highest genetic polymorphism, followed by spelt and then compactum. The mean genetic distance between the populations is higher than that within a population, and similar tendency is detected for individual genomes A, B and D. Therefore, spelt and compactum can be used as potential germplasms for wheat breeding, especially for enriching the genetic variation in genome D. As compared with spelt, the genetic diversity between common wheat and compactum is much smaller, indicating a closer consanguine relationship between these two species. Although the polymorphism revealed by EST-SSR is lower than that by genomic-SSR, it can effectively differentiate diverse genotypes as well. Together with our present results, it is concluded that EST-SSR marker is an ideal marker for assessing the genetic diversity in wheat. Meanwhile, the origin and evolution of hexaploid wheat is also analyzed and discussed.

  9. Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type–specific cancer genes in leukemia

    Science.gov (United States)

    Sauvageau, Martin; Miller, Michelle; Lemieux, Sébastien; Lessard, Julie; Hébert, Josée; Sauvageau, Guy

    2017-01-01

    Proviral insertional mutagenesis is a powerful tool for the discovery of cancer-associated genes. The ability of integrated proviruses to affect gene expression over long distances combined with the lack of methods to determine the expression levels of large numbers of genes in a systematic and truly quantitative manner have limited the identification of cancer genes by proviral insertional mutagenesis. Here, we have characterized a new model of proviral insertional mutagenesis-induced lymphoid tumors derived from Eed Polycomb group gene mutant mice and quantitatively determined the expression levels of all genes within 100 kb of 20 different retroviral common insertion sites (CISs) identified in these tumors. Using high-throughput quantitative reverse transcription–polymerase chain reaction (Q-RT-PCR), we document an average of 13 CIS-associated genes deregulated per tumor, half of which are leukemia subtype–specific, while the others are coordinately deregulated in the majority of tumors analyzed. Interestingly, we find that genes located distantly from common proviral integration sites are as frequently deregulated as proximal genes, with multiple genes affected per integration. Our studies reveal an unsuspected conservation in the group of genes deregulated among phenotypically similar subtypes of lymphoid leukemias, and suggest that identification of common molecular determinants of this disease is within reach. PMID:17906077

  10. The aesthetic interpretation on Wooden Drum Dancing of Wa people

    Directory of Open Access Journals (Sweden)

    Youfeng Wang

    2017-02-01

    Full Text Available The Wa nationality, a typical ethnic group in Yunnan province, is an ancient one lives across Yunnan. The main residences of it are border area beside northern Yunnan and the Wa States in Burma. Among all the Wa dances, Wooden Drum Dancing leads a vital position, and it is also a symbolic dancing in the culture of Wa people. The feature of Wooden Drum Dancing is that every action expending by the beats of wooden drum, namely, first the wooden drum, then the Wooden Drum Dancing. Dancing is an important content in the life of Wa people, and the aesthetics of life comes from dancing, so they present their value on worship by the form of dancing. This article is going to interpret the aesthetic standard on Wa people’s Wooden Drum Dancing by the view of aesthetics, and come into a conclude that the inspiration of such dancing came from practice and their worship to nature and ancestor. The Wooden Drum Dancing displays totally the tough air and solidarity of Wa people, which also presents the fair society of them. The Wooden Drum Dancing is an enriched art that Wa People took from particle life, so dancing of Wa is often classified into the aesthetic area of plain. The information of people’s living situation displayed by Wa dancing also conveys their rich emotions. The sense of beauty within Wooden Drum Dancing will give others a solemn feeling. The formal beauty is displayed by the rhythm of upper part of body, and the power beauty is displayed by the rhythm of the lower part of body.

  11. Dynamic simulation of hydrodynamic model of drum level wave action and sloshing

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In order to build the model of the drum level wave action and sloshing, based on the method of modularization modeling,the hydrodynamic model of drum level wave action and sloshing was developed, and dynamic simulation researches were carried out based on the model. The results indicate that both drum level and drum length have functional relations with period of drum level wave action and sloshing. When the drum level decreases or drum length increases, the period of drum level wave action and sloshing increases, density of liquid and number of sub-module division have little influence on the period of drum level wave action and sloshing. The model was validated by the analytical solution theory of liquid's wave action and sloshing in cuboid container, and the 3D graphics of drum level wave action and sloshing was also obtained. The model can dynamically reflect the rules of wave action and sloshing of water in the container exactly.

  12. Teaching assistants' performance at identifying common introductory student difficulties in mechanics revealed by the Force Concept Inventory

    Science.gov (United States)

    Maries, Alexandru; Singh, Chandralekha

    2016-06-01

    The Force Concept Inventory (FCI) has been widely used to assess student understanding of introductory mechanics concepts by a variety of educators and physics education researchers. One reason for this extensive use is that many of the items on the FCI have strong distractor choices which correspond to students' alternate conceptions in mechanics. Instruction is unlikely to be effective if instructors do not know the common alternate conceptions of introductory physics students and explicitly take into account students' initial knowledge states in their instructional design. Here, we discuss research involving the FCI to evaluate one aspect of the pedagogical content knowledge of teaching assistants (TAs): knowledge of introductory student alternate conceptions in mechanics as revealed by the FCI. For each item on the FCI, the TAs were asked to identify the most common incorrect answer choice of introductory physics students. This exercise was followed by a class discussion with the TAs related to this task, including the importance of knowing student difficulties in teaching and learning. Then, we used FCI pretest and post-test data from a large population (˜900 ) of introductory physics students to assess the extent to which TAs were able to identify alternate conceptions of introductory students related to force and motion. In addition, we carried out think-aloud interviews with graduate students who had more than two semesters of teaching experience in recitations to examine how they reason about the task. We find that while the TAs, on average, performed better than random guessing at identifying introductory students' difficulties with FCI content, they did not identify many common difficulties that introductory physics students have after traditional instruction. We discuss specific alternate conceptions, the extent to which TAs are able to identify them, and results from the think-aloud interviews that provided valuable information about why TAs sometimes

  13. Teaching assistants’ performance at identifying common introductory student difficulties in mechanics revealed by the Force Concept Inventory

    Directory of Open Access Journals (Sweden)

    Alexandru Maries

    2016-05-01

    Full Text Available The Force Concept Inventory (FCI has been widely used to assess student understanding of introductory mechanics concepts by a variety of educators and physics education researchers. One reason for this extensive use is that many of the items on the FCI have strong distractor choices which correspond to students’ alternate conceptions in mechanics. Instruction is unlikely to be effective if instructors do not know the common alternate conceptions of introductory physics students and explicitly take into account students’ initial knowledge states in their instructional design. Here, we discuss research involving the FCI to evaluate one aspect of the pedagogical content knowledge of teaching assistants (TAs: knowledge of introductory student alternate conceptions in mechanics as revealed by the FCI. For each item on the FCI, the TAs were asked to identify the most common incorrect answer choice of introductory physics students. This exercise was followed by a class discussion with the TAs related to this task, including the importance of knowing student difficulties in teaching and learning. Then, we used FCI pretest and post-test data from a large population (∼900 of introductory physics students to assess the extent to which TAs were able to identify alternate conceptions of introductory students related to force and motion. In addition, we carried out think-aloud interviews with graduate students who had more than two semesters of teaching experience in recitations to examine how they reason about the task. We find that while the TAs, on average, performed better than random guessing at identifying introductory students’ difficulties with FCI content, they did not identify many common difficulties that introductory physics students have after traditional instruction. We discuss specific alternate conceptions, the extent to which TAs are able to identify them, and results from the think-aloud interviews that provided valuable information

  14. A-Ha. Drum'n'bassi supernimi FABIO

    Index Scriptorium Estoniae

    2002-01-01

    7.sept. annab norra menukaim popansambel A-Ha Tallinnas Lauluväljakul kontserdi, kus presenteerib ka oma viimast albumit "Lifelines". 14. sept.tuleb drum'n'bassi spetsialist Fabio Tallinna üritusele Circulation

  15. Application Research of Developed Drummed Nuclear Waste Neutron Counting System

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The application researches such as variety of factors affecting the measurement, calibrating etc. are need before the drummed nuclear waste neutron counting system (WNC) can be really put into use after installed at the site.

  16. The Play as Novel: Reappropriating Brecht's "Drums in the Night."

    Science.gov (United States)

    Pollock, Della

    1988-01-01

    Applies Mikhail Bakhtin's theory of the novel to Bertolt Brecht's "Drums in the Night" to illuminate the play's dialogic structure and alienation value, and reappropriate its prerevolutionary dimensions for contemporary use. (MM)

  17. Microbial degradation of lignocellulosic fractions during drum composting of mixed organic waste

    Directory of Open Access Journals (Sweden)

    Vempalli Sudharsan Varma

    2017-11-01

    Full Text Available The study aimed to characterize the microbial population involved in lignocellulose degradation during drum composting of mixed organic waste i.e. vegetable waste, cattle manure, saw dust and dry leaves in a 550 L rotary drum composter. Lignocellulose degradation by different microbial populations was correlated by comparing results from four trials, i.e., Trial 1 (5:4, Trial 2 (6:3, Trial 3 (7:2 and Trial 4 (8:1 of varying waste combinations during 20 days of composting period. Due to proper combination of waste materials and agitation in drum composter, a maximum of 66.5 and 61.4 °C was achieved in Trial 1 and 2 by observing a temperature level of 55 °C for 4–6 d. The study revealed that combinations of waste materials had a major effect on the microbial degradation of waste material and quality of final compost due to its physical properties. However, Trial 1 was observed to have longer thermophilic phase leading to higher degradation of lignocellulosic fractions. Furthermore, Fourier transform infrared spectrometer and fluorescent spectroscopy confirmed the decrease in aliphatic to aromatic ratio and increase in polyphenolic compounds of the compost. Heterotrophic bacteria were observed predominantly due to the readily available organic matter during the initial period of composting. However, fungi and actinomycetes were active in the degradation of lignocellulosic fractions.

  18. Drum Sound Detection in Polyphonic Music with Hidden Markov Models

    OpenAIRE

    Jouni Paulus; Anssi Klapuri

    2009-01-01

    This paper proposes a method for transcribing drums from polyphonic music using a network of connected hidden Markov models (HMMs). The task is to detect the temporal locations of unpitched percussive sounds (such as bass drum or hi-hat) and recognise the instruments played. Contrary to many earlier methods, a separate sound event segmentation is not done, but connected HMMs are used to perform the segmentation and recognition jointly. Two ways of using HMMs are studied: modelling combination...

  19. Drum Sound Detection in Polyphonic Music with Hidden Markov Models

    Directory of Open Access Journals (Sweden)

    Jouni Paulus

    2009-01-01

    Full Text Available This paper proposes a method for transcribing drums from polyphonic music using a network of connected hidden Markov models (HMMs. The task is to detect the temporal locations of unpitched percussive sounds (such as bass drum or hi-hat and recognise the instruments played. Contrary to many earlier methods, a separate sound event segmentation is not done, but connected HMMs are used to perform the segmentation and recognition jointly. Two ways of using HMMs are studied: modelling combinations of the target drums and a detector-like modelling of each target drum. Acoustic feature parametrisation is done with mel-frequency cepstral coefficients and their first-order temporal derivatives. The effect of lowering the feature dimensionality with principal component analysis and linear discriminant analysis is evaluated. Unsupervised acoustic model parameter adaptation with maximum likelihood linear regression is evaluated for compensating the differences between the training and target signals. The performance of the proposed method is evaluated on a publicly available data set containing signals with and without accompaniment, and compared with two reference methods. The results suggest that the transcription is possible using connected HMMs, and that using detector-like models for each target drum provides a better performance than modelling drum combinations.

  20. Drum composting of municipal solid waste.

    Science.gov (United States)

    Kalamdhad, Ajay S; Khwairakpam, Meena; Kazmi, A A

    2012-01-01

    The high initial C/N ratio (> 30) found in Indian municipal solid waste (MSW) leads to more time required for composting (> 3 months), with poor-quality compost production. Therefore, the effects of MSW amended with cattle manure (trial 1) and tree leaves (trial 2) were compared with unamended MSW (control) in a rotary drum composter. The initial C/N ratios of trial 1 and trial 2 were kept at 22, as compared to 32 for the MSW control sample. It was observed that trial 1 produced high-quality and stable compost within 20 days. It showed higher final total nitrogen (2.2%), final total phosphorus (3.2 g/kg) and low electrical conductivity (2.7 dS/m). At the end of 20 days, higher degradation caused lower final oxygen uptake rate (OUR) (1.8 mg/g volatile solids (VS)/day), final CO2 evolution (1.0 mg/g VS/day) and final C/N ratio (7.8). Trial 2 produced good-quality and stable compost resulting in 1.9% of total nitrogen, 2.7% of total phosphorus and low OUR (2.0 mg/g VS/day), CO2 evolution (1.5 mg/g VS/day) and C/N ratio (10.1) after 20 days ofcomposting. However, the control sample with an initial C/N ratio of 32 showed higher OUR (3.6 mg/g VS/day) and CO2 evolution (2.6 mg/g VS/day) comprising a lower concentration of total nitrogen (1.6%) and total phosphorus (2.3 g/kg), which indicated an unstable and low-quality product as compared to trials 1 and 2. Therefore, results showed that the characteristics of MSW amended with cattle manure and tree leaves significantly influence the compost quality and process dynamics in a rotary drum composter.

  1. Meta-analysis reveals association between most common class II haplotype in full-heritage Native Americans and rheumatoid arthritis.

    Science.gov (United States)

    Williams, R C; Jacobsson, L T; Knowler, W C; del Puente, A; Kostyu, D; McAuley, J E; Bennett, P H; Pettitt, D J

    1995-01-01

    The association of RA with the alleles at the HLA system was tested among Pima and Tohono O'odham Indians (Pimans) of the Gila River Indian Community of Arizona. Serologic class I (HLA-A, -B, and -C) alleles were typed in 51 individuals with RA and in 302 without RA. Serologic class II (HLA-DR, DQ; DR52 DR53) alleles were typed in a subset of 47 with RA and 147 without RA. Molecular subtypes of DR3X6, DRB1*1402, and *1406 were determined in 29 individuals, 16 with RA and 13 without RA. Among the cases with RA, 46 of 47 had the serologic antigen HLA-DR3X6, as did 140 of 147 of those without the disease. However, this association was not statistically significant because of the high prevalence of the antigen in the controls. Data from Pimans were analyzed with similar results from the Tlingit and Yakima Indians. A meta-analysis employing the Mantel-Haenszel procedure, stratified by tribe, revealed a statistically significant association between the most common haplotype, DRB1*1402 DQA1*0501 DQB1*0301 DRB3*0101, and RA (summary odds ratio = 2.63, 95% confidence interval = 1.08, 6.46). There was also a statistically significant difference in the genotype distributions of one class I locus, HLA-C, between those with and without RA (chi 2 = 12.4, 5 df; p = 0.03). It is concluded that the association with the most common class II haplotype in full-heritage Native Americans might help explain their high prevalence of RA.

  2. Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

    Directory of Open Access Journals (Sweden)

    Peter A. Bell

    2013-06-01

    Pseudoachondroplasia and multiple epiphyseal dysplasia are genetic skeletal diseases resulting from mutations in cartilage structural proteins. Electron microscopy and immunohistochemistry previously showed that the appearance of the cartilage extracellular matrix (ECM in targeted mouse models of these diseases is disrupted; however, the precise changes in ECM organization and the pathological consequences remain unknown. Our aim was to determine the effects of matrilin-3 and COMP mutations on the composition and extractability of ECM components to inform how these detrimental changes might influence cartilage organization and degeneration. Cartilage was sequentially extracted using increasing denaturants and the extraction profiles of specific proteins determined using SDS-PAGE/Western blotting. Furthermore, the relative composition of protein pools was determined using mass spectrometry for a non-biased semi-quantitative analysis. Western blotting revealed changes in the extraction of matrilins, COMP and collagen IX in mutant cartilage. Mass spectrometry confirmed quantitative changes in the extraction of structural and non-structural ECM proteins, including proteins with roles in cellular processes such as protein folding and trafficking. In particular, genotype-specific differences in the extraction of collagens XII and XIV and tenascins C and X were identified; interestingly, increased expression of several of these genes has recently been implicated in susceptibility and/or progression of murine osteoarthritis. We demonstrated that mutation of matrilin-3 and COMP caused changes in the extractability of other cartilage proteins and that proteomic analyses of Matn3 V194D, Comp T585M and Comp DelD469 mouse models revealed both common and discrete disease signatures that provide novel insight into skeletal disease mechanisms and cartilage degradation.

  3. Phylogenetic analysis reveals common antimicrobial resistant Campylobacter coli population in antimicrobial-free (ABF and commercial swine systems.

    Directory of Open Access Journals (Sweden)

    Macarena P Quintana-Hayashi

    Full Text Available The objective of this study was to compare the population biology of antimicrobial resistant (AR Campylobacter coli isolated from swine reared in the conventional and antimicrobial-free (ABF swine production systems at farm, slaughter and environment. A total of 200 C. coli isolates selected from fecal, environmental, and carcass samples of ABF (n = 100 and conventional (n = 100 swine production systems were typed by multilocus sequence typing (MLST. Sequence data from seven housekeeping genes was analyzed for the identification of allelic profiles, sequence types (STs and clonal complex determination. Phylogenetic trees were generated to establish the relationships between the genotyped isolates. A total of 51 STs were detected including two novel alleles (glnA 424 and glyA 464 and 14 novel STs reported for the first time. The majority of the C. coli isolates belonged to ST-854 (ABF: 31, conventional: 17, and were grouped in clonal complex ST-828 (ABF: 68%, conventional: 66%. The mean genetic diversity (H for the ABF (0.3963+/-0.0806 and conventional (0.4655+/-0.0714 systems were similar. The index of association (I(A(S for the ABF (I(A(S= 0.1513 and conventional (I(A(S = 0.0991 C. coli populations were close to linkage equilibrium, indicative of a freely recombining population. Identical STs were detected between the pigs and their environment both at farm and slaughter. A minimum spanning tree revealed the close clustering of C. coli STs that originated from swine and carcass with those from the environment. In conclusion, our study reveals a genotypic diverse C. coli population that shares a common ancestry in the conventional and ABF swine production systems. This could potentially explain the high prevalence of antimicrobial resistant C. coli in the ABF system in the absence of antimicrobial selection pressure.

  4. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.

    Science.gov (United States)

    Yurtsever, Zeynep; Scheaffer, Suzanne M; Romero, Arthur G; Holtzman, Michael J; Brett, Tom J

    2015-04-01

    The p38 MAP kinases (p38 MAPKs) represent an important family centrally involved in mediating extracellular signaling. Recent studies indicate that family members such as MAPK13 (p38δ) display a selective cellular and tissue expression and are therefore involved in specific diseases. Detailed structural studies of all p38 MAPK family members are crucial for the design of specific inhibitors. In order to facilitate such ventures, the structure of MAPK13 was determined in both the inactive (unphosphorylated; MAPK13) and active (dual phosphorylated; MAPK13/pTpY) forms. Here, the first preparation, crystallization and structure determination of MAPK13/pTpY are presented and the structure is compared with the previously reported structure of MAPK13 in order to facilitate studies for structure-based drug design. A comprehensive analysis of inactive versus active structures for the p38 MAPK family is also presented. It is found that MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14. Surprisingly, the analysis of activated p38 MAPK structures (MAP12/pTpY, MAPK13/pTpY and MAPK14/pTpY) reveals that, despite a high degree of sequence similarity, different side chains are used to coordinate the phosphorylated residues. There are also differences in the rearrangement of the hinge region that occur in MAPK14 compared with MAPK13 which would affect inhibitor binding. A thorough examination of all of the active (phosphorylated) and inactive (unphosphorylated) p38 MAPK family member structures was performed to reveal a common structural basis of activation for the p38 MAP kinase family and to identify structural differences that may be exploited for developing family member-specific inhibitors.

  5. Study on pick arrangement of shearer drum based on load fluctuation

    Institute of Scientific and Technical Information of China (English)

    DU Chang-long; LIU Song-yong; CUI Xin-xia; LI Ti-jian

    2008-01-01

    According to the coal or rock cutting theory, a mechanical model and computing formula for a pick and the drum load fluctuation model were established in order to obtain relationships between pick arrangements and drum fluctuation loads, drum rotary speeds and haulage speeds. Based on a minimum load fluctuation, an optimal mathematical model was established for drum pick arrangements. The effects of pick arrangements (including punnett square, sequence, aberrance Ⅰ and Ⅱ) on the drum load fluctuation coefficient are discussed. The relationships between the pick arrangements of the drum with different start vanes and the cutting load fluctuation coefficient, the drum rotary speed and haulage speed were also studied. The results indicate that the punnett square arrangement has a smaller cutting load fluctuation coefficient than other forms of arrangement and the drum with the 4-start vanes has the smallest coefficient. The drum rotary speed and haulage speed are affected not only by pick arrangements, but also by the number of vanes.

  6. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.

    Science.gov (United States)

    Hayashi, Chie; Papadopoulos, George; Gudino, Cynthia V; Weinberg, Ellen O; Barth, Kenneth R; Madrigal, Andrés G; Chen, Yang; Ning, Hua; LaValley, Michael; Gibson, Frank C; Hamilton, James A; Genco, Caroline A

    2012-10-01

    Clinical and epidemiological studies have implicated chronic infections in the development of atherosclerosis. It has been proposed that common mechanisms of signaling via TLRs link stimulation by multiple pathogens to atherosclerosis. However, how pathogen-specific stimulation of TLR4 contributes to atherosclerosis progression remains poorly understood. In this study, atherosclerosis-prone apolipoprotein-E null (ApoE(-/-)) and TLR4-deficient (ApoE(-/-)TLR4(-/-)) mice were orally infected with the periodontal pathogen Porphyromonas gingivalis. ApoE(-/-)TLR4(-/-) mice were markedly more susceptible to atherosclerosis after oral infection with P. gingivalis. Using live animal imaging, we demonstrate that enhanced lesion progression occurs progressively and was increasingly evident with advancing age. Immunohistochemical analysis of lesions from ApoE(-/-)TLR4(-/-) mice revealed an increased inflammatory cell infiltrate composed primarily of macrophages and IL-17 effector T cells (Th17), a subset linked with chronic inflammation. Furthermore, enhanced atherosclerosis in TLR4-deficient mice was associated with impaired development of Th1 immunity and regulatory T cell infiltration. In vitro studies suggest that the mechanism of TLR4-mediated protective immunity may be orchestrated by dendritic cell IL-12 and IL-10, which are prototypic Th1 and regulatory T cell polarizing cytokines. We demonstrate an atheroprotective role for TLR4 in response to infection with the oral pathogen P. gingivalis. Our results point to a role for pathogen-specific TLR signaling in chronic inflammation and atherosclerosis.

  7. Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate

    Science.gov (United States)

    Mangold, Elisabeth; Böhmer, Anne C.; Ishorst, Nina; Hoebel, Ann-Kathrin; Gültepe, Pinar; Schuenke, Hannah; Klamt, Johanna; Hofmann, Andrea; Gölz, Lina; Raff, Ruth; Tessmann, Peter; Nowak, Stefanie; Reutter, Heiko; Hemprich, Alexander; Kreusch, Thomas; Kramer, Franz-Josef; Braumann, Bert; Reich, Rudolf; Schmidt, Gül; Jäger, Andreas; Reiter, Rudolf; Brosch, Sibylle; Stavusis, Janis; Ishida, Miho; Seselgyte, Rimante; Moore, Gudrun E.; Nöthen, Markus M.; Borck, Guntram; Aldhorae, Khalid A.; Lace, Baiba; Stanier, Philip; Knapp, Michael; Ludwig, Kerstin U.

    2016-01-01

    Nonsyndromic cleft lip with/without cleft palate (nsCL/P) and nonsyndromic cleft palate only (nsCPO) are the most frequent subphenotypes of orofacial clefts. A common syndromic form of orofacial clefting is Van der Woude syndrome (VWS) where individuals have CL/P or CPO, often but not always associated with lower lip pits. Recently, ∼5% of VWS-affected individuals were identified with mutations in the grainy head-like 3 gene (GRHL3). To investigate GRHL3 in nonsyndromic clefting, we sequenced its coding region in 576 Europeans with nsCL/P and 96 with nsCPO. Most strikingly, nsCPO-affected individuals had a higher minor allele frequency for rs41268753 (0.099) than control subjects (0.049; p = 1.24 × 10−2). This association was replicated in nsCPO/control cohorts from Latvia, Yemen, and the UK (pcombined = 2.63 × 10−5; ORallelic = 2.46 [95% CI 1.6–3.7]) and reached genome-wide significance in combination with imputed data from a GWAS in nsCPO triads (p = 2.73 × 10−9). Notably, rs41268753 is not associated with nsCL/P (p = 0.45). rs41268753 encodes the highly conserved p.Thr454Met (c.1361C>T) (GERP = 5.3), which prediction programs denote as deleterious, has a CADD score of 29.6, and increases protein binding capacity in silico. Sequencing also revealed four novel truncating GRHL3 mutations including two that were de novo in four families, where all nine individuals harboring mutations had nsCPO. This is important for genetic counseling: given that VWS is rare compared to nsCPO, our data suggest that dominant GRHL3 mutations are more likely to cause nonsyndromic than syndromic CPO. Thus, with rare dominant mutations and a common risk variant in the coding region, we have identified an important contribution for GRHL3 in nsCPO. PMID:27018475

  8. Transcriptome analysis reveals genes commonly induced by Botrytis cinerea infection, cold, drought and oxidative stresses in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Arjun Sham

    Full Text Available Signaling pathways controlling biotic and abiotic stress responses may interact synergistically or antagonistically. To identify the similarities and differences among responses to diverse stresses, we analyzed previously published microarray data on the transcriptomic responses of Arabidopsis to infection with Botrytis cinerea (a biotic stress, and to cold, drought, and oxidative stresses (abiotic stresses. Our analyses showed that at early stages after B. cinerea inoculation, 1498 genes were up-regulated (B. cinerea up-regulated genes; BUGs and 1138 genes were down-regulated (B. cinerea down-regulated genes; BDGs. We showed a unique program of gene expression was activated in response each biotic and abiotic stress, but that some genes were similarly induced or repressed by all of the tested stresses. Of the identified BUGs, 25%, 6% and 12% were also induced by cold, drought and oxidative stress, respectively; whereas 33%, 7% and 5.5% of the BDGs were also down-regulated by the same abiotic stresses. Coexpression and protein-protein interaction network analyses revealed a dynamic range in the expression levels of genes encoding regulatory proteins. Analysis of gene expression in response to electrophilic oxylipins suggested that these compounds are involved in mediating responses to B. cinerea infection and abiotic stress through TGA transcription factors. Our results suggest an overlap among genes involved in the responses to biotic and abiotic stresses in Arabidopsis. Changes in the transcript levels of genes encoding components of the cyclopentenone signaling pathway in response to biotic and abiotic stresses suggest that the oxylipin signal transduction pathway plays a role in plant defense. Identifying genes that are commonly expressed in response to environmental stresses, and further analyzing the functions of their encoded products, will increase our understanding of the plant stress response. This information could identify targets

  9. The Saami shaman's drum and the star horizons

    Directory of Open Access Journals (Sweden)

    Bo Sommarström

    1991-01-01

    Full Text Available The aim of this contribution is to examine the possible influences of stellar constellations on the positioning of the drum figures on the drums used by the Saami people during the 17th and 18th centuries. Certain of the drum figures seem to have a similar position to corresponding figures on traditional star maps, both with respect to single star constellations and to some members of the Zodiac circle. The most general correspondences between star maps and the painted designs on drums depend on the existence of a cross for determining the four cardinal points in both cases. The star constellations compared here with the drum-figures are in fact peripheral Saami skies. It is hard to believe that they can have played any vital role in their capacity as star symbols within the frame of the Saamis' own astral cosmology. It is more probable that the earthly meanings of most of the figures were more important to the drummer.

  10. Study on the dynamic performance of concrete mixer's mixing drum

    National Research Council Canada - National Science Library

    Jiapeng Yang; Hua Zeng; Tongqing Zhu; Qi An

    2017-01-01

    When working, the geometric distribution shape of concrete in concrete mixing truck's rotary drum changes continuously, which cause a great difficulty for studying the dynamic performance of the mixing drum...

  11. Image data rate converter having a drum with a fixed head and a rotatable head

    Science.gov (United States)

    Billingsley, F. C. (Inventor)

    1973-01-01

    A data-rate converter is disclosed comprising a rotatable data-storing drum with at least one fixed read/record head and a rotatable read/record head. The latter is rotatable in a circular path about the drum axis of rotation. The drum is positionable in any one of a plurality of axial positions with respect to the heads, so that at least one drum track is aligned with the fixed head in one drum position and with the rotatable head in another drum position. When a track is aligned with the fixed head, data may be recorded therin or read out therefrom at a rate which is a function of drum rotation, while when aligned with the rotatable head, data may be recorded or read out at a rate which is a function of the rates and directions of rotation of both the drum and the head.

  12. RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.

    Science.gov (United States)

    Cui, Julia Yue; Klaassen, Curtis D

    2016-09-01

    entire hepatic transcriptome correlated with a marked change in the expression of many DNA and histone epigenetic modifiers. In conclusion, the present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands. Results from this study will further support the role of these receptors in regulating the homeostasis of xenobiotic and intermediary metabolism in the liver, and aid in distinguishing between PXR and CAR signaling at various physiological and pathophysiological conditions. This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

  13. Renewable Energy Opportunities at Fort Drum, New York

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Scott A.; Orrell, Alice C.; Solana, Amy E.; Williamson, Jennifer L.; Hand, James R.; Russo, Bryan J.; Weimar, Mark R.; Rowley, Steven; Nesse, Ronald J.

    2010-10-20

    This document provides an overview of renewable resource potential at Fort Drum, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Drum took place on May 4 and 5, 2010.

  14. On the efficiency calibration of a drum waste assay system

    CERN Document Server

    Dinescu, L; Cazan, I L; Macrin, R; Caragheorgheopol, G; Rotarescu, G

    2002-01-01

    The efficiency calibration of a gamma spectroscopy waste assay system, constructed by IFIN-HH, was performed. The calibration technique was based on the assumption of a uniform distribution of the source activity in the drum and also a uniform sample matrix. A collimated detector (HPGe--20% relative efficiency) placed at 30 cm from the drum was used. The detection limit for sup 1 sup 3 sup 7 Cs and sup 6 sup 0 Co is approximately 45 Bq/kg for a sample of about 400 kg and a counting time of 10 min. A total measurement uncertainty of -70% to +40% was estimated.

  15. 77 FR 24200 - American Drum & Pallet, Memphis, Shelby County, TN; Notice of Settlement

    Science.gov (United States)

    2012-04-23

    ... AGENCY American Drum & Pallet, Memphis, Shelby County, TN; Notice of Settlement AGENCY: Environmental... settlement for reimbursement of past response costs concerning the American Drum and Pallet Superfund Site...-04- 2012-3770 or Site name American Drum & Pallet Superfund Site by one of the following methods: www...

  16. 77 FR 47840 - American Drum and Pallet Company Site; Memphis, Shelby County, Tennessee; Notice of settlement

    Science.gov (United States)

    2012-08-10

    ... AGENCY American Drum and Pallet Company Site; Memphis, Shelby County, Tennessee; Notice of settlement... Agency has entered into a settlement for past response costs concerning the American Drum and Pallet... Drum and Pallet Company Site by one of the following methods: www.epa.gov/region4/superfund/programs...

  17. 77 FR 8255 - Constitution Road Drum Superfund Site, Atlanta, Dekalb County, GA; Notice of Settlement

    Science.gov (United States)

    2012-02-14

    ... AGENCY Constitution Road Drum Superfund Site, Atlanta, Dekalb County, GA; Notice of Settlement AGENCY... entered into a settlement for past response costs concerning the Constitution Road Drum Superfund Site... available from Ms. Paula V. Painter. Submit your comments by Site name Constitution Road Drum Superfund...

  18. RATIONALE FOR CENTERING CAPACITY OF REDISIGNED BELT CONVEYOR DRUMS

    Directory of Open Access Journals (Sweden)

    V. V. Suglobov

    2016-02-01

    Full Text Available Purpose. In the study is necessary: 1 to justify aligning drums of a new design of belt conveyors; 2 to develop a method for calculating and determining the rational design parameters of drums depending on the technical parameters of the conveyor belt (the length of the conveyor, belt width, the performance of the conveyor, the diameter of the drive and tension drums, etc.; 3 to carry out pilot studies of efficiency conveyor belt in a production environment in order to determine the magnitude of dynamic loads and a comparative evaluation of the effectiveness of the centering ability of conventional and new designs of drums. Methodology. To substantiate the effectiveness of the centering ability of the drums of a new design by the authors developed a mathematical model of interaction of the tape with the drum. Mathematical simulation of tape reels with new design comes to drawing up a differential equation of the belt based on the dynamic component and restoring force. This model allowed us to estimate the movement of the tape in the transverse direction based on the calculated additional dynamic loads and forces on the investigated centering a conveyor belt with given specifications. For the first time the technique of calculating and determining the rational parameters of the drums, which allows determining the design parameters of the centering portions, depending on the mechanical properties and geometric parameters of the tape. Findings. With the help of mathematical modeling the scientifically substantiated effect of centering the ability of the new design of the drum, which ensures stable tape running along the longitudinal axis of the conveyor. The authors made the following conclusions: 1 the mathematical model of interaction with the new belt design of the drum, which allowed to describe the belt in the transverse direction in view of additional dynamic loads and renewable power was developed; 2 the method of calculation and

  19. Development of New Drummed Nuclear Waste Neutron Counting System

    Institute of Scientific and Technical Information of China (English)

    ZHU; Li-qun; XU; Xiao-ming; BAI; Lei; LI; Xin-jun; GU; Shao-gang; HE; Li-xia; WANG; Mian

    2012-01-01

    <正>The development of a new neutron counting system (Fig. 1) for 200 L drummed radioactive waste measurement has been accomplished in this year. This waste neutron counting system is mainly used for solid radioactive waste classification. It is based on the passive neutron counting technique. The amount of radionuclide contained in the waste is

  20. DRUMS: a human disease related unique gene mutation search engine.

    Science.gov (United States)

    Li, Zuofeng; Liu, Xingnan; Wen, Jingran; Xu, Ye; Zhao, Xin; Li, Xuan; Liu, Lei; Zhang, Xiaoyan

    2011-10-01

    With the completion of the human genome project and the development of new methods for gene variant detection, the integration of mutation data and its phenotypic consequences has become more important than ever. Among all available resources, locus-specific databases (LSDBs) curate one or more specific genes' mutation data along with high-quality phenotypes. Although some genotype-phenotype data from LSDB have been integrated into central databases little effort has been made to integrate all these data by a search engine approach. In this work, we have developed disease related unique gene mutation search engine (DRUMS), a search engine for human disease related unique gene mutation as a convenient tool for biologists or physicians to retrieve gene variant and related phenotype information. Gene variant and phenotype information were stored in a gene-centred relational database. Moreover, the relationships between mutations and diseases were indexed by the uniform resource identifier from LSDB, or another central database. By querying DRUMS, users can access the most popular mutation databases under one interface. DRUMS could be treated as a domain specific search engine. By using web crawling, indexing, and searching technologies, it provides a competitively efficient interface for searching and retrieving mutation data and their relationships to diseases. The present system is freely accessible at http://www.scbit.org/glif/new/drums/index.html.

  1. The Way of the Drum: When Earth Becomes Heart.

    Science.gov (United States)

    Antone, Grafton; Turchetti, Lois Provost

    Two Native people describe their respective journeys to healing, journeys that involved the rediscovery of language and culture. In Part I, "Healing the Tears of Yesterday by the Drum Today: The Oneida Language Is a Healing Medicine" (Grafton Antone), the first narrator taught the Oneida language to adult students at a community center.…

  2. Non-Destructive Assay of Curium Contaminated Transuranic Waste Drums

    Energy Technology Data Exchange (ETDEWEB)

    Foster, L.A.

    1998-11-01

    At the Plutonium Facility at Los Alamos National Laboratory, a series of non-destructive assays were performed on five transuranic waste (TRU) drums containing non-plutonium scrap metal that was potentially contaminated with weapons grade plutonium and trace quantities of curium. Typically, waste drums containing metal matrices are assayed for plutonium content using passive neutron coincidence counting techniques. The presence of trace quantities of Cm-244 prevents this type of analysis because of the strong coincidence signal created by spontaneous fission of Cm-244. To discriminate between the plutonium and curium materials present, an active neutron measurement technique was used. A Cf shuffler designed for measurement of uranium bearing materials was calibrated for plutonium in the active mode. The waste drums were then assayed for plutonium content in the shuffler using the active-mode calibration. The curium contamination levels were estimated from the difference between the active-mode measurement in the shuffler and a passive assay in a neutron coincidence counter. Far field gamma-ray measurements were made to identify additional radioactive contaminants and to corroborate the plutonium measurement results obtained from the active-mode assay. This report describes in detail the measurement process used for characterization of these waste drums. The measurement results and the estimated uncertainty will be presented.

  3. Teaching Ugandan Traditional Dances and Drumming in Summer Camps

    Science.gov (United States)

    Mabingo, Alfdaniels

    2017-01-01

    Dances and drum rhythms from African traditions have been integrated into summer camp activities in the United States as a response to the ever-globalized environments in which these camps are located and the diversity of the campers and teachers that they attract. This reflective article draws on critical reflections, observations and experiences…

  4. Development of Interpersonal Coordination between Peers during a Drumming Task

    Science.gov (United States)

    Endedijk, Hinke M.; Ramenzoni, Veronica C. O.; Cox, Ralf F. A.; Cillessen, Antonius H. N.; Bekkering, Harold; Hunnius, Sabine

    2015-01-01

    During social interaction, the behavior of interacting partners becomes coordinated. Although interpersonal coordination is well-studied in adults, relatively little is known about its development. In this project we explored how 2-, 3-, and 4-year-old children spontaneously coordinated their drumming with a peer. Results showed that all children…

  5. Evaluation of an Intergrated / Biocoagulant-sand filter Drum for ...

    African Journals Online (AJOL)

    User

    2015-03-18

    Mar 18, 2015 ... many homes do not have proper toilets. There is the ... are farming and grazing on the different watersheds of Age for and. Bamendankwe and ... bed and included; 150 L carrying capacity drum (plastic), 1½ yards of hose, four ...

  6. Small-Scale Experiments.10-gallon drum experiment summary

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, David M.

    2015-02-05

    A series of sub-scale (10-gallon) drum experiments were conducted to characterize the reactivity, heat generation, and gas generation of mixtures of chemicals believed to be present in the drum (68660) known to have breached in association with the radiation release event at the Waste Isolation Pilot Plant (WIPP) on February 14, 2014, at a scale expected to be large enough to replicate the environment in that drum but small enough to be practical, safe, and cost effective. These tests were not intended to replicate all the properties of drum 68660 or the event that led to its breach, or to validate a particular hypothesis of the release event. They were intended to observe, in a controlled environment and with suitable diagnostics, the behavior of simple mixtures of chemicals in order to determine if they could support reactivity that could result in ignition or if some other ingredient or event would be necessary. There is a significant amount of uncertainty into the exact composition of the barrel; a limited sub-set of known components was identified, reviewed with Technical Assessment Team (TAT) members, and used in these tests. This set of experiments was intended to provide a framework to postulate realistic, data-supported hypotheses for processes that occur in a “68660-like” configuration, not definitively prove what actually occurred in 68660.

  7. Occupational hygiene in a Finnish drum composting plant.

    Science.gov (United States)

    Tolvanen, Outi; Nykänen, Jenni; Nivukoski, Ulla; Himanen, Marina; Veijanen, Anja; Hänninen, Kari

    2005-01-01

    Bioaerosols (microbes, dust and endotoxins) and volatile organic compounds (VOCs) were determined in the working air of a drum composting plant treating source-separated catering waste. Different composting activities at the Oulu drum composting plant take place in their own units separated by modular design and constructions. Important implication of this is that the control room is a relatively clean working environment and the risk of exposure to harmful factors is low. However, the number of viable airborne microbes was high both in the biowaste receiving hall and in the drum composting hall. The concentration (geometric average) of total microbes was 21.8 million pcs/m3 in the biowaste receiving hall, 13.9 million pcs/m3 in the drum composting hall, and just 1.4 million pcs/m3 in the control room. Endotoxin concentrations were high in the biowaste receiving hall and in the drum composting hall. The average (arithmetic) endotoxin concentration was over the threshold value of 200 EU/m3 in both measurement locations. In all working areas, the average (arithmetic) dust concentrations were in a low range of 0.6-0.7 mg/m3, being below the Finnish threshold value of 5 mg/m3. In the receiving hall and drum composting hall, the concentrations of airborne microbes and endotoxins may rise to levels hazardous to health during prolonged exposure. It is advisable to use a respirator mask (class P3) in these areas. Detected volatile organic compounds were typical compounds of composting plants: carboxylic acids and their esters, alcohols, ketones, aldehydes, and terpenes. Concentrations of VOCs were much lower than the Finnish threshold limit values (Finnish TLVs), many of the quantified compounds exceeded their threshold odour concentrations (TOCs). Primary health effects due VOCs were not presumable at these concentrations but unpleasant odours may cause secondary symptoms such as nausea and hypersensitivity reactions. This situation is typical of composting plants where

  8. Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons

    NARCIS (Netherlands)

    van den Bos, Hilda; Spierings, Diana C J; Taudt, Aaron S; Bakker, Bjorn; Porubský, David; Falconer, Ester; Novoa, Carolina; Halsema, Nancy; Kazemier, Hinke G; Hoekstra-Wakker, Karina; Guryev, Victor; den Dunnen, Wilfred F A; Foijer, Floris; Tatché, Maria Colomé; Boddeke, Hendrikus W G M; Lansdorp, Peter M

    2016-01-01

    Background: Alzheimer's disease (AD) is a neurodegenerative disease of the brain and the most common form of dementia in the elderly. Aneuploidy, a state in which cells have an abnormal number of chromosomes, has been proposed to play a role in neurodegeneration in AD patients. Several studies using

  9. Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons

    NARCIS (Netherlands)

    van den Bos, Hilda; Spierings, Diana C J; Taudt, Aaron S; Bakker, Bjorn; Porubský, David; Falconer, Ester; Novoa, Carolina; Halsema, Nancy; Kazemier, Hinke G; Hoekstra-Wakker, Karina; Guryev, Victor; den Dunnen, Wilfred F A; Foijer, Floris; Tatché, Maria Colomé; Boddeke, Hendrikus W G M; Lansdorp, Peter M

    2016-01-01

    BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease of the brain and the most common form of dementia in the elderly. Aneuploidy, a state in which cells have an abnormal number of chromosomes, has been proposed to play a role in neurodegeneration in AD patients. Several studies using

  10. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms.

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    Jonna Jalanka-Tuovinen

    Full Text Available BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce. The aim of this study was to characterize the intestinal microbiota of healthy adults and specifically address its temporal stability, core microbiota and relation with intestinal symptoms. We carried out a longitudinal study by following a set of 15 healthy Finnish subjects for seven weeks and regularly assessed their intestinal bacteria and archaea with the Human Intestinal Tract (HIT Chip, a phylogenetic microarray, in conjunction with qPCR analyses. The health perception and occurrence of intestinal symptoms was recorded by questionnaire at each sampling point. PRINCIPAL FINDINGS: A high overall temporal stability of the microbiota was observed. Five subjects showed transient microbiota destabilization, which correlated not only with the intake of antibiotics but also with overseas travelling and temporary illness, expanding the hitherto known factors affecting the intestinal microbiota. We identified significant correlations between the microbiota and common intestinal symptoms, including abdominal pain and bloating. The most striking finding was the inverse correlation between Bifidobacteria and abdominal pain: subjects who experienced pain had over five-fold less Bifidobacteria compared to those without pain. Finally, a novel computational approach was used to define the common core microbiota, highlighting the role of the analysis depth in finding the phylogenetic core and estimating its size. The in-depth analysis suggested that we share a substantial number of our intestinal phylotypes but as they represent highly variable proportions of the total community, many of them often remain undetected. CONCLUSIONS/SIGNIFICANCE: A global and high-resolution microbiota analysis was carried out to determine the temporal stability, the associations with intestinal symptoms, and the

  11. Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.

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    Sumeet A Khetarpal

    2011-12-01

    Full Text Available Genome-wide association studies (GWAS have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies are being utilized to catalogue the allelic spectrum at GWAS loci. The goal of these studies is to identify causative variants and missing heritability, including heritability due to low frequency and rare alleles with large phenotypic impact. Whereas rare variant efforts have primarily focused on nonsynonymous coding variants, we hypothesized that noncoding variants in these loci are also functionally important. Using the HDL-C gene LIPG as an example, we explored the effect of regulatory variants identified through resequencing of subjects at HDL-C extremes on gene expression, protein levels, and phenotype. Resequencing a portion of the LIPG promoter and 5' UTR in human subjects with extreme HDL-C, we identified several rare variants in individuals from both extremes. Luciferase reporter assays were used to measure the effect of these rare variants on LIPG expression. Variants conferring opposing effects on gene expression were enriched in opposite extremes of the phenotypic distribution. Minor alleles of a common regulatory haplotype and noncoding GWAS SNPs were associated with reduced plasma levels of the LIPG gene product endothelial lipase (EL, consistent with its role in HDL-C catabolism. Additionally, we found that a common nonfunctional coding variant associated with HDL-C (rs2000813 is in linkage disequilibrium with a 5' UTR variant (rs34474737 that decreases LIPG promoter activity. We attribute the gene regulatory role of rs34474737 to the observed association of the coding variant with plasma EL levels and HDL-C. Taken together, the findings show that both rare and common noncoding regulatory variants are important contributors to the allelic spectrum in complex trait loci.

  12. GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases

    Institute of Scientific and Technical Information of China (English)

    Yin Yao Shugart; Ying Wang; Wei-Hua Jia; Yi-Xin Zeng

    2011-01-01

    Increasing evidence suggests that multiple genes in the human leukocyte antigen (HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.

  13. Molecular markers reveal spatially segregated cryptic species in a critically endangered fish, the common skate (Dipturus batis).

    Science.gov (United States)

    Griffiths, Andrew M; Sims, David W; Cotterell, Stephen P; El Nagar, Aliya; Ellis, Jim R; Lynghammar, Arve; McHugh, Matthew; Neat, Francis C; Pade, Nicolas G; Queiroz, Nuno; Serra-Pereira, Bárbara; Rapp, Toby; Wearmouth, Victoria J; Genner, Martin J

    2010-05-22

    Many sharks and skates are particularly vulnerable to overfishing because of their large size, slow growth, late maturity and low fecundity. In Europe dramatic population declines have taken place in common skate (Dipturus batis L.), one of the largest demersal fish in regional shelf seas, leading to extirpations from substantial parts of its former range. Here we report the discovery of cryptic species in common skate collected from the northeast Atlantic continental shelf. Data from nuclear microsatellite markers indicated two clearly distinct clades and phylogenetic analysis of mitochondrial DNA sequences demonstrated monophyly of each one of them. Capture locations showed evidence of strong spatial segregation, with one taxon occurring mainly in waters off the southern British Isles and around Rockall, while the other was restricted to more northerly shelf waters. These apparently cryptic species showed overlapping substrate and depth preferences, but distributional limits were closely related to temperature gradients, potentially indicating thermal limits to their distributions. This discovery of hidden diversity within a large, critically endangered marine vertebrate demonstrates how marine biodiversity can be underestimated, even in such a relatively well-studied and heavily exploited region.

  14. Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans.

    Science.gov (United States)

    Noble, Daniel C; Aoki, Scott T; Ortiz, Marco A; Kim, Kyung Won; Verheyden, Jamie M; Kimble, Judith

    2016-01-01

    Germ cell specification as sperm or oocyte is an ancient cell fate decision, but its molecular regulation is poorly understood. In Caenorhabditis elegans, the FOG-1 and FOG-3 proteins behave genetically as terminal regulators of sperm fate specification. Both are homologous to well-established RNA regulators, suggesting that FOG-1 and FOG-3 specify the sperm fate post-transcriptionally. We predicted that FOG-1 and FOG-3, as terminal regulators of the sperm fate, might regulate a battery of gamete-specific differentiation genes. Here we test that prediction by exploring on a genomic scale the messenger RNAs (mRNAs) associated with FOG-1 and FOG-3. Immunoprecipitation of the proteins and their associated mRNAs from spermatogenic germlines identifies 81 FOG-1 and 722 FOG-3 putative targets. Importantly, almost all FOG-1 targets are also FOG-3 targets, and these common targets are strongly biased for oogenic mRNAs. The discovery of common target mRNAs suggested that FOG-1 and FOG-3 work together. Consistent with that idea, we find that FOG-1 and FOG-3 proteins co-immunoprecipitate from both intact nematodes and mammalian tissue culture cells and that they colocalize in germ cells. Taking our results together, we propose a model in which FOG-1 and FOG-3 work in a complex to repress oogenic transcripts and thereby promote the sperm fate.

  15. Multilocus sequence analysis of Bacillus thuringiensis serovars navarrensis, bolivia and vazensis and Bacillus weihenstephanensis reveals a common phylogeny.

    Science.gov (United States)

    Soufiane, Brahim; Baizet, Mathilde; Côté, Jean-Charles

    2013-01-01

    The Bacillus cereus group sensu lato includes six closely-related bacterial species: Bacillus cereus, Bacillus anthracis, Bacillus thuringiensis, Bacillus mycoides, Bacillus pseudomycoides and Bacillus weihenstephanensis. B. thuringiensis is distinguished from the other species mainly by the appearance of an inclusion body upon sporulation. B. weihenstephanensis is distinguished based on its psychrotolerance and the presence of specific signature sequences in the 16S rRNA gene and cspA genes. A total of seven housekeeping genes (glpF, gmK, ilvD, pta, purH, pycA and tpi) from different B. thuringiensis serovars and B. weihenstephanensis strains were amplified and their nucleotide sequences determined. A maximum likelihood phylogenetic tree was inferred from comparisons of the concatenated sequences. B. thuringiensis serovars navarrensis, bolivia and vazensis clustered not with the other B. thuringiensis serovars but rather with the B. weihenstephanensis strains, indicative of a common phylogeny. In addition, specific signature sequences and single nucleotide polymorphisms common to B. thuringiensis serovars navarrensis, bolivia and vazensis and the B. weihenstephanensis strains, and absent in the other B. thuringiensis serovars, were identified.

  16. Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami.

    Science.gov (United States)

    Huyghe, Jeroen R; Fransen, Erik; Hannula, Samuli; Van Laer, Lut; Van Eyken, Els; Mäki-Torkko, Elina; Lysholm-Bernacchi, Alana; Aikio, Pekka; Stephan, Dietrich A; Sorri, Martti; Huentelman, Matthew J; Van Camp, Guy

    2010-05-01

    The Saami from Fennoscandia are believed to represent an ancient, genetically isolated population with no evidence of population expansion. Theoretical work has indicated that under this demographic scenario, extensive linkage disequilibrium (LD) is generated by genetic drift. Therefore, it has been suggested that the Saami would be particularly suited for genetic association studies, offering a substantial power advantage and allowing more economic study designs. However, no study has yet assessed this claim. As part of a GWAS for a complex trait, we evaluated the relative power for association studies of common variants in the Finnish Saami. LD patterns in the Saami were very similar to those in the non-African HapMap reference panels. Haplotype diversity was reduced and, on average, levels of LD were higher in the Saami as compared with those in the HapMap panels. However, using a 'hidden' SNP approach we show that this does not translate into a power gain in association studies. Contrary to earlier claims, we show that for a given set of common SNPs, genomic coverage attained in the Saami is similar to that in the non-African HapMap panels. Nevertheless, the reduced haplotype diversity could potentially facilitate gene identification, especially if multiple rare variants play a role in disease etiology. Our results further indicate that the HapMap is a useful resource for genetic studies in the Saami.

  17. Common neural mechanisms for the evaluation of facial trustworthiness and emotional expressions as revealed by behavioral adaptation.

    Science.gov (United States)

    Engell, Andrew D; Todorov, Alexander; Haxby, James V

    2010-01-01

    People rapidly and automatically evaluate faces along many social dimensions. Here, we focus on judgments of trustworthiness, which approximate basic valence evaluation of faces, and test whether these judgments are an overgeneralization of the perception of emotional expressions. We used a behavioral adaptation paradigm to investigate whether the previously noted perceptual similarities between trustworthiness and emotional expressions of anger and happiness extend to their underlying neural representations. We found that adapting to angry or happy facial expressions causes trustworthiness evaluations of subsequently rated neutral faces to increase or decrease, respectively. Further, we found no such modulation of trustworthiness evaluations after participants were adapted to fearful expressions, suggesting that this effect is specific to angry and happy expressions. We conclude that, in line with the overgeneralization hypothesis, a common neural system is engaged during the evaluation of facial trustworthiness and expressions of anger and happiness.

  18. pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia.

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    Karl Simin

    2004-02-01

    Full Text Available Retinoblastoma 1 (pRb and the related pocket proteins, retinoblastoma-like 1 (p107 and retinoblastoma-like 2 (p130 (pRb(f, collectively, play a pivotal role in regulating eukaryotic cell cycle progression, apoptosis, and terminal differentiation. While aberrations in the pRb-signaling pathway are common in human cancers, the consequence of pRb(f loss in the mammary gland has not been directly assayed in vivo. We reported previously that inactivating these critical cell cycle regulators in divergent cell types, either brain epithelium or astrocytes, abrogates the cell cycle restriction point, leading to increased cell proliferation and apoptosis, and predisposing to cancer. Here we report that mouse mammary epithelium is similar in its requirements for pRb(f function; Rb(f inactivation by T(121, a fragment of SV40 T antigen that binds to and inactivates pRb(f proteins, increases proliferation and apoptosis. Mammary adenocarcinomas form within 16 mo. Most apoptosis is regulated by p53, which has no impact on proliferation, and heterozygosity for a p53 null allele significantly shortens tumor latency. Most tumors in p53 heterozygous mice undergo loss of the wild-type p53 allele. We show that the mechanism of p53 loss of heterozygosity is not simply the consequence of Chromosome 11 aneuploidy and further that chromosomal instability subsequent to p53 loss is minimal. The mechanisms for pRb and p53 tumor suppression in the epithelia of two distinct tissues, mammary gland and brain, are indistinguishable. Further, this study has produced a highly penetrant breast cancer model based on aberrations commonly observed in the human disease.

  19. Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.

    Science.gov (United States)

    Johnston, Harvey E; Carter, Matthew J; Cox, Kerry L; Dunscombe, Melanie; Manousopoulou, Antigoni; Townsend, Paul A; Garbis, Spiros D; Cragg, Mark S

    2017-03-01

    Approximately 800,000 leukemia and lymphoma cases are diagnosed worldwide each year. Burkitt's lymphoma (BL) and chronic lymphocytic leukemia (CLL) are examples of contrasting B-cell cancers; BL is a highly aggressive lymphoid tumor, frequently affecting children, whereas CLL typically presents as an indolent, slow-progressing leukemia affecting the elderly. The B-cell-specific overexpression of the myc and TCL1 oncogenes in mice induce spontaneous malignancies modeling BL and CLL, respectively. Quantitative mass spectrometry proteomics and isobaric labeling were employed to examine the biology underpinning contrasting Eμ-myc and Eμ-TCL1 B-cell tumors. Additionally, the plasma proteome was evaluated using subproteome enrichment to interrogate biomarker emergence and the systemic effects of tumor burden. Over 10,000 proteins were identified (qIL5) receptor. IL5 treatment promoted Eμ-TCL1 tumor proliferation, suggesting an amplification of IL5-induced AKT signaling by TCL1. Tumor plasma contained a substantial tumor lysis signature, most prominent in Eμ-myc plasma, whereas Eμ-TCL1 plasma contained signatures of immune-response, inflammation and microenvironment interactions, with putative biomarkers in early-stage cancer. These findings provide a detailed characterization of contrasting B-cell tumor models, identifying common and specific tumor mechanisms. Integrated plasma proteomics allowed the dissection of a systemic response and a tumor lysis signature present in early- and late-stage cancers, respectively. Overall, this study suggests common B-cell cancer signatures exist and illustrates the potential of the further evaluation of B-cell cancer subtypes by integrative proteomics.

  20. Genetic diversity of common bean accessions from former Yugoslav Republic of Macedonia as revealed by molecular and morphological markers

    Directory of Open Access Journals (Sweden)

    Maras Marko

    2016-01-01

    Full Text Available Cultivation of common bean has a long tradition in the Former Yugoslav Republic of Macedonia (FYROM and is still nowadays important part of the human diet. In a study reported here 71 accessions from the FYROM were assessed for genetic diversity with the aim to provide information on genetic structure of Macedonian common bean germplasm and to depict its peculiarities. A total of 71 accessions were assessed using 13 microsatellite and 16 morphological markers. The average number of alleles per microsatellite was 5.8, and ranged from three to 16 alleles. High capacity of selected markers for distinguishing genotypes was identified by the calculation of a very low value of probability of identity. The relationship among 71 studied accessions was assessed by hierarchical cluster analysis. A very clear separation of accessions into two groups was observed in the UPGMA dendrogram. The larger represented Andean gene pool and contained 40 accessions (56% of total, while the other 31 accessions (44% of total composed Mesoamerican gene pool. The two groups were successfully discriminated by eight morphological traits. Within the larger Andean cluster in the UPGMA dendrogram a sub-group of 16 climbing accessions was separated from 24 bush accessions. The absence of the string in the pods of the climbers suggests that this sub-group comprises snap beans grown primarily for their fresh pods. There were eight morphological traits in total that distinguished the two Andean sub-groups. Assessment of genetic relationship among accessions, their classification into respective gene pool and identification of morphological peculiarities provided valuable information for the management of plant gene bank and Macedonian bean breeding program.

  1. Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Darcie J.; Jerga, Agoston; Rock, Charles O.; White, Stephen W. (SJCH)

    2008-08-11

    Soluble diacylglycerol (DAG) kinases function as regulators of diacylglycerol metabolism in cell signaling and intermediary metabolism. We report the structure of a DAG kinase, DgkB from Staphylococcus aureus, both as the free enzyme and in complex with ADP. The molecule is a tight homodimer, and each monomer comprises two domains with the catalytic center located within the interdomain cleft. Two distinctive features of DkgB are a structural Mg{sup 2+} site and an associated Asp{center_dot}water{center_dot}Mg{sup 2+} network that extends toward the active site locale. Site-directed mutagenesis revealed that these features play important roles in the catalytic mechanism. The key active site residues and the components of the Asp{center_dot}water{center_dot}Mg{sup 2+} network are conserved in the catalytic cores of the mammalian signaling DAG kinases, indicating that these enzymes use the same mechanism and have similar structures as DgkB.

  2. Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases.

    Science.gov (United States)

    Miller, Darcie J; Jerga, Agoston; Rock, Charles O; White, Stephen W

    2008-07-01

    Soluble diacylglycerol (DAG) kinases function as regulators of diacylglycerol metabolism in cell signaling and intermediary metabolism. We report the structure of a DAG kinase, DgkB from Staphylococcus aureus, both as the free enzyme and in complex with ADP. The molecule is a tight homodimer, and each monomer comprises two domains with the catalytic center located within the interdomain cleft. Two distinctive features of DkgB are a structural Mg2+ site and an associated Asp*water*Mg2+ network that extends toward the active site locale. Site-directed mutagenesis revealed that these features play important roles in the catalytic mechanism. The key active site residues and the components of the Asp*water*Mg2+ network are conserved in the catalytic cores of the mammalian signaling DAG kinases, indicating that these enzymes use the same mechanism and have similar structures as DgkB.

  3. A nanogenerator as a self-powered sensor for measuring the vibration spectrum of a drum membrane.

    Science.gov (United States)

    Yu, Aifang; Zhao, Yong; Jiang, Peng; Wang, Zhong Lin

    2013-02-08

    A nanogenerator (NG) is a device that converts vibration energy into electricity. Here, a flexible, small size and lightweight NG is successfully demonstrated as an active sensor for detecting the vibration spectrum of a drum membrane without the use of an external power source. The output current/voltage signal of the NG is a direct measure of the strain of the local vibrating drum membrane that contains rich informational content, such as, notably, the vibration frequency, vibration speed and vibration amplitude. In comparison to the laser vibrometer, which is excessively complex and expensive, this kind of small and low cost sensor based on an NG is also capable of detecting the local vibration frequency of a drum membrane accurately. A spatial arrangement of the NGs on the membrane can provide position-dependent vibration information on the surface. The measured frequency spectrum can be understood on the basis of the theoretically calculated vibration modes. This work expands the application of NGs and reveals the potential for developing sound wave detection, environmental/infrastructure monitoring and many more applications.

  4. A maximum likelihood QTL analysis reveals common genome regions controlling resistance to Salmonella colonization and carrier-state

    Directory of Open Access Journals (Sweden)

    Thanh-Son Tran

    2012-05-01

    Full Text Available Abstract Background The serovars Enteritidis and Typhimurium of the Gram-negative bacterium Salmonella enterica are significant causes of human food poisoning. Fowl carrying these bacteria often show no clinical disease, with detection only established post-mortem. Increased resistance to the carrier state in commercial poultry could be a way to improve food safety by reducing the spread of these bacteria in poultry flocks. Previous studies identified QTLs for both resistance to carrier state and resistance to Salmonella colonization in the same White Leghorn inbred lines. Until now, none of the QTLs identified was common to the two types of resistance. All these analyses were performed using the F2 inbred or backcross option of the QTLExpress software based on linear regression. In the present study, QTL analysis was achieved using Maximum Likelihood with QTLMap software, in order to test the effect of the QTL analysis method on QTL detection. We analyzed the same phenotypic and genotypic data as those used in previous studies, which were collected on 378 animals genotyped with 480 genome-wide SNP markers. To enrich these data, we added eleven SNP markers located within QTLs controlling resistance to colonization and we looked for potential candidate genes co-localizing with QTLs. Results In our case the QTL analysis method had an important impact on QTL detection. We were able to identify new genomic regions controlling resistance to carrier-state, in particular by testing the existence of two segregating QTLs. But some of the previously identified QTLs were not confirmed. Interestingly, two QTLs were detected on chromosomes 2 and 3, close to the locations of the major QTLs controlling resistance to colonization and to candidate genes involved in the immune response identified in other, independent studies. Conclusions Due to the lack of stability of the QTLs detected, we suggest that interesting regions for further studies are those that were

  5. Migration routes and strategies in a highly aerial migrant, the common swift Apus apus, revealed by light-level geolocators.

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    Susanne Åkesson

    Full Text Available The tracking of small avian migrants has only recently become possible by the use of small light-level geolocators, allowing the reconstruction of whole migration routes, as well as timing and speed of migration and identification of wintering areas. Such information is crucial for evaluating theories about migration strategies and pinpointing critical areas for migrants of potential conservation value. Here we report data about migration in the common swift, a highly aerial and long-distance migrating species for which only limited information based on ringing recoveries about migration routes and wintering areas is available. Six individuals were successfully tracked throughout a complete migration cycle from Sweden to Africa and back. The autumn migration followed a similar route in all individuals, with an initial southward movement through Europe followed by a more southwest-bound course through Western Sahara to Sub-Saharan stopovers, before a south-eastward approach to the final wintering areas in the Congo basin. After approximately six months at wintering sites, which shifted in three of the individuals, spring migration commenced in late April towards a restricted stopover area in West Africa in all but one individual that migrated directly towards north from the wintering area. The first part of spring migration involved a crossing of the Gulf of Guinea in those individuals that visited West Africa. Spring migration was generally wind assisted within Africa, while through Europe variable or head winds were encountered. The average detour at about 50% could be explained by the existence of key feeding sites and wind patterns. The common swift adopts a mixed fly-and-forage strategy, facilitated by its favourable aerodynamic design allowing for efficient use of fuel. This strategy allowed swifts to reach average migration speeds well above 300 km/day in spring, which is higher than possible for similar sized passerines. This study

  6. Meta-analysis of several gene lists for distinct types of cancer: A simple way to reveal common prognostic markers

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    Sun Xiao

    2007-04-01

    Full Text Available Abstract Background Although prognostic biomarkers specific for particular cancers have been discovered, microarray analysis of gene expression profiles, supported by integrative analysis algorithms, helps to identify common factors in molecular oncology. Similarities of Ordered Gene Lists (SOGL is a recently proposed approach to meta-analysis suitable for identifying features shared by two data sets. Here we extend the idea of SOGL to the detection of significant prognostic marker genes from microarrays of multiple data sets. Three data sets for leukemia and the other six for different solid tumors are used to demonstrate our method, using established statistical techniques. Results We describe a set of significantly similar ordered gene lists, representing outcome comparisons for distinct types of cancer. This kind of similarity could improve the diagnostic accuracies of individual studies when SOGL is incorporated into the support vector machine algorithm. In particular, we investigate the similarities among three ordered gene lists pertaining to mesothelioma survival, prostate recurrence and glioma survival. The similarity-driving genes are related to the outcomes of patients with lung cancer with a hazard ratio of 4.47 (p = 0.035. Many of these genes are involved in breakdown of EMC proteins regulating angiogenesis, and may be used for further research on prognostic markers and molecular targets of gene therapy for cancers. Conclusion The proposed method and its application show the potential of such meta-analyses in clinical studies of gene expression profiles.

  7. Single-Cell Analysis of Growth in Budding Yeast and Bacteria Reveals a Common Size Regulation Strategy.

    Science.gov (United States)

    Soifer, Ilya; Robert, Lydia; Amir, Ariel

    2016-02-08

    To maintain a constant cell size, dividing cells have to coordinate cell-cycle events with cell growth. This coordination has long been supposed to rely on the existence of size thresholds determining cell-cycle progression [1]. In budding yeast, size is controlled at the G1/S transition [2]. In agreement with this hypothesis, the size at birth influences the time spent in G1: smaller cells have a longer G1 period [3]. Nevertheless, even though cells born smaller have a longer G1, the compensation is imperfect and they still bud at smaller cell sizes. In bacteria, several recent studies have shown that the incremental model of size control, in which size is controlled by addition of a constant volume (in contrast to a size threshold), is able to quantitatively explain the experimental data on four different bacterial species [4-7]. Here, we report on experimental results for the budding yeast Saccharomyces cerevisiae, finding, surprisingly, that cell size control in this organism is very well described by the incremental model, suggesting a common strategy for cell size control with bacteria. Additionally, we argue that for S. cerevisiae the "volume increment" is not added from birth to division, but rather between two budding events. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins.

    Science.gov (United States)

    Provasi, Davide; Murcia, Marta; Coller, Barry S; Filizola, Marta

    2009-11-01

    The beta3 integrin family members alphaIIbeta3 and alphaVbeta3 signal bidirectionally through long-range allosteric changes, including a transition from a bent unliganded-closed low-affinity state to an extended liganded-open high-affinity state. To obtain an atomic-level description of this transition in an explicit solvent, we carried out targeted molecular dynamics simulations of the headpieces of alphaIIbeta3 and alphaVbeta3 integrins. Although minor differences were observed between these receptors, our results suggest a common transition pathway in which the hybrid domain swing-out is accompanied by conformational changes within the beta3 betaA (I-like) domain that propagate through the alpha7 helix C-terminus, and are followed by the alpha7 helix downward motion and the opening of the beta6-alpha7 loop. Breaking of contact interactions between the beta6-alpha7 loop and the alpha1 helix N-terminus results in helix straightening, internal rearrangements of the specificity determining loop (SDL), movement of the beta1-alpha1 loop toward the metal ion dependent adhesion site (MIDAS), and final changes at the interfaces between the beta3 betaA (I-like) domain and either the hybrid or the alpha beta-propeller domains. Taken together, our results suggest novel testable hypotheses of intradomain and interdomain interactions responsible for beta3 integrin activation.

  9. Narrow-front loop migration in a population of the common cuckoo Cuculus canorus, as revealed by satellite telemetry.

    Science.gov (United States)

    Willemoes, Mikkel; Strandberg, Roine; Klaassen, Raymond H G; Tøttrup, Anders P; Vardanis, Yannis; Howey, Paul W; Thorup, Kasper; Wikelski, Martin; Alerstam, Thomas

    2014-01-01

    Narrow migration corridors known in diurnal, social migrants such as raptors, storks and geese are thought to be caused by topographical leading line effects in combination with learning detailed routes across generations. Here, we document narrow-front migration in a nocturnal, solitary migrant, the common cuckoo Cuculus canorus, using satellite telemetry. We tracked the migration of adult cuckoos from the breeding grounds in southern Scandinavia (n = 8), to wintering sites in south-western Central Africa (n = 6) and back to the breeding grounds (n = 3). Migration patterns were very complex; in addition to the breeding and wintering sites, six different stopover sites were identified during the 16,000 km annual route that formed a large-scale clockwise loop. Despite this complexity, individuals showed surprisingly similar migration patterns, with very little variation between routes. We compared observed tracks with simulated routes based on vector orientation (with and without effects of barriers on orientation and survival). Observed distances between routes were often significantly smaller than expected if the routes were established on the basis of an innate vector orientation programme. Average distance between individuals in eastern Sahel after having migrated more than 5,000 km for example, was merely 164 km. This implies that more sophisticated inherent guiding mechanisms, possibly involving elements of intermediate goal area navigation or more elaborate external cues, are necessary to explain the complex narrow-front migration pattern observed for the cuckoos in this study.

  10. Narrow-front loop migration in a population of the common cuckoo Cuculus canorus, as revealed by satellite telemetry.

    Directory of Open Access Journals (Sweden)

    Mikkel Willemoes

    Full Text Available Narrow migration corridors known in diurnal, social migrants such as raptors, storks and geese are thought to be caused by topographical leading line effects in combination with learning detailed routes across generations. Here, we document narrow-front migration in a nocturnal, solitary migrant, the common cuckoo Cuculus canorus, using satellite telemetry. We tracked the migration of adult cuckoos from the breeding grounds in southern Scandinavia (n = 8, to wintering sites in south-western Central Africa (n = 6 and back to the breeding grounds (n = 3. Migration patterns were very complex; in addition to the breeding and wintering sites, six different stopover sites were identified during the 16,000 km annual route that formed a large-scale clockwise loop. Despite this complexity, individuals showed surprisingly similar migration patterns, with very little variation between routes. We compared observed tracks with simulated routes based on vector orientation (with and without effects of barriers on orientation and survival. Observed distances between routes were often significantly smaller than expected if the routes were established on the basis of an innate vector orientation programme. Average distance between individuals in eastern Sahel after having migrated more than 5,000 km for example, was merely 164 km. This implies that more sophisticated inherent guiding mechanisms, possibly involving elements of intermediate goal area navigation or more elaborate external cues, are necessary to explain the complex narrow-front migration pattern observed for the cuckoos in this study.

  11. Designing the sound of a cut-off drum

    CERN Document Server

    Martinetti, Pierre

    2015-01-01

    The spectral action in noncommutative geometry naturally implements an ultraviolet cut-off, by counting the eigenvalues of a (generalized) Dirac operator lower than an energy of unification. Inverting the well known question "how to hear the shape of a drum ?", we ask what drum can be designed by hearing the truncated music of the spectral action ? This makes sense because the same Dirac operator also determines the metric, via Connes distance. The latter thus offers an original way to implement the high-momentum cut-off of the spectral action as a short distance cut-off on space. This is a non-technical presentation of the results of http://arxiv.org/abs/1305.2605

  12. Reliability modeling of hydraulic system of drum shearer machine

    Institute of Scientific and Technical Information of China (English)

    SEYED HADI Hoseinie; MOHAMMAD Ataie; REZA Khalookakaei; UDAY Kumar

    2011-01-01

    The hydraulic system plays an important role in supplying power and its transition to other working parts of a coal shearer machine.In this paper,the reliability of the hydraulic system of a drum shearer was analyzed.A case study was done in the Tabas Coal Mine in Iran for failure data collection.The results of the statistical analysis show that the time between failures (TBF)data of this system followed the 3-parameters Weibull distribution.There is about a 54% chance that the hydraulic system of the drum shearer will not fail for the first 50 h of operation.The developed model shows that the reliability of the hydraulic system reduces to a zero value after approximately 1 650 hours of operation.The failure rate of this system decreases when time increases.Therefore,corrective maintenance(run-to-failure)was selected as the best maintenance strategy for it.

  13. Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells.

    Science.gov (United States)

    Liu, Mengling; Xia, Yingfeng; Ding, Jane; Ye, Bingwei; Zhao, Erhu; Choi, Jeong-Hyeon; Alptekin, Ahmet; Yan, Chunhong; Dong, Zheng; Huang, Shuang; Yang, Liqun; Cui, Hongjuan; Zha, Yunhong; Ding, Han-Fei

    2016-10-04

    High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues of therapeutic interventions. Here, we report the isolation and propagation of neuroblastoma sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma with MYCN amplification. Transcriptional profiling reveals that mouse neuroblastoma sphere-forming cells acquire a metabolic program characterized by transcriptional activation of the cholesterol and serine-glycine synthesis pathways, primarily as a result of increased expression of sterol regulatory element binding factors and Atf4, respectively. This metabolic reprogramming is recapitulated in high-risk human neuroblastomas and is prognostic for poor clinical outcome. Genetic and pharmacological inhibition of the metabolic program markedly decreases the growth and tumorigenicity of both mouse neuroblastoma sphere-forming cells and human neuroblastoma cell lines. These findings suggest a therapeutic strategy for targeting the metabolic program of high-risk neuroblastoma. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  14. A MODULAR STORE FOR DRUMS OF RADIOACTIVE WASTE

    Energy Technology Data Exchange (ETDEWEB)

    Sims, J.; Holden, G.

    2003-02-27

    Currently, the United Kingdom has no facility for the disposal of any waste above the low level category, indicating that all intermediate and high level waste, apart from spent fuel, has to be stored on the site of origin. To meet this storage requirement, nuclear sites are resorting to converting existing buildings or contemplating the construction of dedicated facilities, resulting in considerable cost implications. These financing aspects not only concern the construction strategy but also impinge on the ultimate decommissioning costs associated with each particular nuclear site. This paper reports on an investigation to apply the commercially available interlocking hollow block system to the design of a store for drums of radioactive waste. This block system can be quickly, and cost effectively, erected and filled with a choice of dense material. Later, the store can be dismantled with a minimum of disposable radioactive waste and the complete facility re - erected at another location if required, considerably reducing both capital construction and decommissioning costs. The investigation also encompassed a detailed review of the equipment required to place the drums of waste into the store, resulting in a scheme for a remotely operated vehicle that did not rely on umbilical control cables. The drum handler design included for 100% redundancy of all functions, meaning that whichever component failed, the handler was always recoverable to effect the necessary repair. The ultimate aim of the waste drum store review was to produce a facility that was as safe as a conventionally constructed unit, but at a lower overall building and decommissioning cost.

  15. AUTOMATIC CONTROL SYSTEM OF THE DRUM BOILER SUPERHEATED STEAM TEMPERATURE.

    Directory of Open Access Journals (Sweden)

    Juravliov A.A.

    2006-04-01

    Full Text Available The control system of the temperature of the superheated steam of the drum boiler is examined. Main features of the system are the PI-controller in the external control loop and introduction of the functional component of the error signal of the external control loop with the negative feedback of the error signal between the prescribed value of steam flowrate and the signal of the steam flowrate in the exit of the boiler in the internal control loop.

  16. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.

    Science.gov (United States)

    Richardson, Jessica; Blunck, Rikard; Ge, Pinghua; Selvin, Paul R; Bezanilla, Francisco; Papazian, Diane M; Correa, Ana M

    2006-10-24

    Voltage-dependent ion channels are fundamental to the physiology of excitable cells because they underlie the generation and propagation of the action potential and excitation-contraction coupling. To understand how ion channels work, it is important to determine their structures in different conformations in a membrane environment. The validity of the crystal structure for the prokaryotic K(+) channel, K(V)AP, has been questioned based on discrepancies with biophysical data from functional eukaryotic channels, underlining the need for independent structural data under native conditions. We investigated the structural organization of two prokaryotic voltage-gated channels, NaChBac and K(V)AP, in liposomes by using luminescence resonance energy transfer. We describe here a transmembrane packing representation of the voltage sensor and pore domains of the prokaryotic Na channel, NaChBac. We find that NaChBac and K(V)AP share a common arrangement in which the structures of the Na and K selective pores and voltage-sensor domains are conserved. The packing arrangement of the voltage-sensing region as determined by luminescence resonance energy transfer differs significantly from that of the K(V)AP crystal structure, but resembles that of the eukaryotic K(V)1.2 crystal structure. However, the voltage-sensor domain in prokaryotic channels is closer to the pore domain than in the K(V)1.2 structure. Our results indicate that prokaryotic and eukaryotic channels that share similar functional properties have similar helix arrangements, with differences arising likely from the later introduction of additional structural elements.

  17. Bacterial communities of two ubiquitous Great Barrier Reef corals reveals both site- and species-specificity of common bacterial associates.

    Directory of Open Access Journals (Sweden)

    E Charlotte E Kvennefors

    Full Text Available BACKGROUND: Coral-associated bacteria are increasingly considered to be important in coral health, and altered bacterial community structures have been linked to both coral disease and bleaching. Despite this, assessments of bacterial communities on corals rarely apply sufficient replication to adequately describe the natural variability. Replicated data such as these are crucial in determining potential roles of bacteria on coral. METHODOLOGY/PRINCIPAL FINDINGS: Denaturing Gradient Gel Electrophoresis (DGGE of the V3 region of the 16S ribosomal DNA was used in a highly replicated approach to analyse bacterial communities on both healthy and diseased corals. Although site-specific variations in the bacterial communities of healthy corals were present, host species-specific bacterial associates within a distinct cluster of gamma-proteobacteria could be identified, which are potentially linked to coral health. Corals affected by "White Syndrome" (WS underwent pronounced changes in their bacterial communities in comparison to healthy colonies. However, the community structure and bacterial ribotypes identified in diseased corals did not support the previously suggested theory of a bacterial pathogen as the causative agent of the syndrome. CONCLUSIONS/SIGNIFICANCE: This is the first study to employ large numbers of replicated samples to assess the bacterial communities of healthy and diseased corals, and the first culture-independent assessment of bacterial communities on WS affected Acroporid corals on the GBR. Results indicate that a minimum of 6 replicate samples are required in order to draw inferences on species, spatial or health-related changes in community composition, as a set of clearly distinct bacterial community profiles exist in healthy corals. Coral bacterial communities may be both site and species specific. Furthermore, a cluster of gamma-proteobacterial ribotypes may represent a group of specific common coral and marine

  18. Handling 78,000 drums of mixed-waste sludge

    Energy Technology Data Exchange (ETDEWEB)

    Berry, J.B.; Gilliam, T.M.; Harrington, E.S.; Youngblood, E.L. (Oak Ridge National Lab., TN (United States)); Baer, M.B. (Oak Ridge K-25 Site, TN (United States))

    1991-01-01

    The Oak Ridge Gaseous Diffusion Plant (now know as the Oak Ridge K-25 Site) prepared two mixed-waste surface impoundments for closure by removing the sludge and contaminated pond-bottom clay and attempting to process it into durable, nonleachable, concrete monoliths. Interim, controlled, above-ground storage of the stabilized waste was planned until final disposition. The strategy for disposal included delisting the stabilized pond sludge from hazardous to nonhazardous and disposing of the delisted monoliths as radioactive waste. Because of schedule constraints and process design and control deficiencies, {approximately}46,000 drums of material in various stages of solidification and {approximately}32,000 drums of unprocessed sludge are presently being stored. In addition, the abandoned treatment facility still contains {approximately}16,000 gal of raw sludge. Such conditions do not comply with the requirements set forth by the Resource Conservation and Recovery Act (RCRA) for the storage of listed waste. Various steps are being taken to bring the storage of {approximately}78,000 drums of mixed waste into compliance with RCRA. This paper (1) reviews the current situation, (2) discusses the plan for remediation of regulatory noncompliances, including decanting liquid from stabilized waste and dewatering untreated waste, and (3) provides an assessment of alternative raw-waste treatment processes. 1 ref., 6 figs., 2 tabs.

  19. Kinematics and Path Following Control of an Articulated Drum Roller

    Science.gov (United States)

    BIAN, Yongming; YANG, Meng; FANG, Xiaojun; WANG, Xiahui

    2017-07-01

    Automatic navigation of an articulated drum roller, which is an articulated steering type vehicle widely used in the construction industry, is highly expected for operation cost reduction and improvement of work efficiency. In order to achieve the path following control, considering that its steering system is articulated steering and two frames are articulated by an active revolute joint, a kinematic model and an error dynamic state-space equation of an articulated drum roller are proposed. Besides, a state-feedback control law based on Lyapunov stability theory is also designed, which can be proved to achieve the purpose of control by the analysis of stability. What's more, to evaluate the performance of the proposed method, simulation under the MATLAB/Simulink and experiments using positioning algorithm and errors correction at the uneven construction site are performed, with initial displacement error (-1.5 m), heading error (-0.11 rad) and steering angle (-0.19 rad). Finally, simulation and experimental results show that the errors and steering angle can decrease gradually, and converge to zero with time. Meanwhile, the control input is not saturated. An articulated drum roller can lock into a desired path with the proposed method in uneven fields.

  20. Scaling of heat transfer in granular material in rotating drums

    Science.gov (United States)

    Yohannes, Bereket; Emady, Heather; Pardes, Ingrid; Javed, Maham; Borghard, William; Glasser, Benjamin; Muzzio, Fernando; Cuitino, Alberto

    Several industrial processes involve thermal treatment of granular materials and powders, in devices such as rotating drums, to bring about a desired chemical and/or physical transformation. Developing a better understanding of the heat transfer process can significantly improve the quality of the end product and efficiency. However, there is a lack of predictive models, for example, to predict the evolution of the distribution and average of the particles' temperature, particularly for the purposes of scale-up from laboratory scale experiments to manufacturing scale productions. We used discrete element method (DEM) based simulations to study the distribution of particles' temperature in rotating drums at low temperature. Various physical, mechanical, and thermal properties of particles were considered in the simulations and in the analysis. In addition, the effect of operating conditions such as size of drum, material fill level, and speed of rotation on the heat transfer were investigated. Based on the simulations, we identified timescales relevant to the heat transfer process and developed a relationship between these timescales that can be used to predict the average temperature of particles. We also found that the evolution of the temperature distribution, since different particles may have different temperatures, can be predicted based on these timescales. These findings can be used to predict the required time to heat up all particles to the desired temperature.

  1. Multipurpose explosive (MPX) drum-shaped packaging design criteria

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    In fiscal year 1993, the Transportation Management Division of the US Department of Energy sponsored an engineering study, completed by Westinghouse Hanford Company, to examine the viability of a generic packaging design able to satisfy multiple explosives packaging needs. Engineering study results indicated that a box-shaped and drum-shaped (allowable outer packaging shapes) multipurpose explosive (MPX) packaging would mitigate the impact of US Department of Transportation (DOT) Docket HM-181. The MPX packaging concept was for a multi-modal, reusable outer packaging to facilitate the transport of prepackaged solid explosives, most of which are in obsolete pre-HM-181 specification packagings, inside of the MPX packaging. This document sets forth the design criteria for the drum-shaped MPX packaging. These design criteria delineate minimum functional and regulation mandated requirements for the MPX drum-shaped packaging. Functional requirements are derived from US Department of Energy site personnel involved in explosives manufacturing and shipping. Regulatory requirements are derived from DOT and International Air Transport Association transport regulations, enabling the MPX packaging to be used by commercial carriers in either highway or air transportation modes.

  2. W-026, acceptance test report TRU empty drum compactor (submittal{number_sign}634)

    Energy Technology Data Exchange (ETDEWEB)

    Watson, T.L.

    1997-06-18

    On 10/19/96 and 10/21/96, the 06/04/96 version of the Empty Drum Compactor Acceptance Test Procedure was used to perform tests by INET Corporation at the Hanford WRAP facility. The INET compaction components were installed in the Diversified glovebox. The Diversified glovebox and cart and the INET compaction components, EDC HPU and drum centering device constitute the Empty Drum Compactor.

  3. Characterization of void volume VOC concentration in vented TRU waste drums. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Liekhus, K.J.

    1995-08-01

    A test program has been conducted at the Idaho National Engineering Laboratory to demonstrate that the concentration of volatile organic compounds within the innermost layer of confinement in a vented waste drum can be estimated using a model incorporating diffusion and permeation transport principles and limited waste drum sampling data. This final report summarizes the experimental measurements and model predictions for transuranic waste drums containing solidified sludges and solid waste.

  4. Characterization of voic volume VOC concentration in vented TRU waste drums. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Liekhus, K.J.

    1994-12-01

    A test program has been conducted at the Idaho National Engineering Laboratory to demonstrate that the concentration of volatile organic compounds within the innermost layer of confinement in a vented waste drum can be estimated using a model incorporating diffusion and permeation transport principles and limited waste drum sampling data. This final report summarizes the experimental measurements and model predictions for transuranic waste drums containing solidified sludges and solid waste.

  5. Influence de l'énergie de surface d'un tambour deshuileur sur son efficacité de relevage Influence of the Surface Energy of a Deoiling Drum on Its Gathering Efficiency

    Directory of Open Access Journals (Sweden)

    Aurelle Y.

    2006-11-01

    our laboratory and is currently marketed by Société Elf. To simulate industrial conditions of the use of deoiling drums, we chose a tangential rotation speed of 0. 24 m/s, appreciably corresponding to the rotation speed of Elf drums. Likewise, the pollution sequences performed in the laboratory were examined to simulate the different working conditions of an industrial drum. Figures 5, 6, 7 and 8 show the volumes of kerosine and water gathered for each of the four drums as a function of time, together with the cumulative volumes of kerosine added to the test tank (Fig. 2 to simulate sequential pollution. The experimental results obtained reveal the different types of behavior by deoiling drums according to the nature of the material making them up :1 If all the drums tested were first immersed in and imbibed by the kerosine phase before being immersed in water, they were able to recover the polluting kerosine phase under excellent conditions. No appreciable difference in behavior was found among the different materials (Fig. 17. 2 At the end of the recovery of the initial pollution, with the drums rotating in water, three different types of behavior could be seen as a function of time. The steel drum immediately forms a very large film of water over its entire surface area (Fig. 5. The PVC and polypropylene drums are not immediately covered by water after the disappearance of the kerosine film. However, after several hours, a slight rise in the water film can be seen in preferential areas of the drums. This dynamic phenomenon increased in time, and after 24 hours of operating the entire surface area of the drums was covered by a homogeneous water film (Figs. 6c and 7c. Only the fluorocarbon-derivative drum, after having entirely recovered the hydrocarbon phase, was not covered by water after 24 hours. It thus proves to be very advantageous from the industrial standpoint since it is highly selective with regard to hydrocarbons. 3 After this conditioning phase in

  6. Measurement and Monte Carlo Calculation of Waste Drum Filled With Radioactive Aqueous Solution

    Institute of Scientific and Technical Information of China (English)

    XU; Li-jun; ZHANG; Wei-dong; YE; Hong-sheng; LIN; Min; CHEN; Xi-lin; GUO; Xiao-qing

    2012-01-01

    <正>Theoretically the best calibrating source of gamma scan system (SGS) is a waste drum filled with uniform distribution of medium and radioactive nuclides. However, in reality, waste drums usually full of solid substance, which are difficult to be prepared in a completely uniformly distributed state. To reduce measurement uncertainty of the radioactivity of waste drums prepared using the method of shell source, a waste drum filled with radioactive aqueous solution was prepared. Besides, its radioactivity was measured by a SGS device and calculated using Monte Carlo method to verify the exact geometric model, which

  7. Modeling unsteady-state VOC transport in simulated waste drums. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Liekhus, K.J.; Gresham, G.L.; Peterson, E.S.; Rae, C.; Hotz, N.J.; Connolly, M.J.

    1994-01-01

    This report is a revision of an EG&G Idaho informal report originally titled Modeling VOC Transport in Simulated Waste Drums. A volatile organic compound (VOC) transport model has been developed to describe unsteady-state VOC permeation and diffusion within a waste drum. Model equations account for three primary mechanisms for VOC transport from a void volume within the drum. These mechanisms are VOC permeation across a polymer boundary, VOC diffusion across an opening in a volume boundary, and VOC solubilization in a polymer boundary. A series of lab-scale experiments was performed in which the VOC concentration was measured in simulated waste drums under different conditions. A lab-scale simulated waste drum consisted of a sized-down 55-gal metal drum containing a modified rigid polyethylene drum liner. Four polyethylene bags were sealed inside a large polyethylene bag, supported by a wire cage, and placed inside the drum liner. The small bags were filled with VOC-air gas mixture and the VOC concentration was measured throughout the drum over a period of time. Test variables included the type of VOC-air gas mixtures introduced into the small bags, the small bag closure type, and the presence or absence of a variable external heat source. Model results were calculated for those trials where the permeability had been measured.

  8. Steam drum level control studies of a natural circulation multi loop reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Rajesh; Contractor, A.D.; Srivastava, Abhishek; Lele, H.G. [Bhabha Atomic Research Centre, Trombay, Mumbai (India). Reactor Safety Div.; Vaze, K.K. [Bhabha Atomic Research Centre, Trombay, Mumbai (India). Reactor Design and Development Group

    2013-12-15

    The proposed heavy water moderated and light water cooled pressure tube type boiling water reactor works on natural circulation at all power levels. It has parallel inter-connected loops with 452 boiling channels in the main heat transport system configuration. These multiple (four) interconnected loops influence the steam drum level control adversely through the common reactor inlet header. Alternate design studies made earlier for efficient control of SD levels have shown favorable results. This has lead to explore further the present scheme with the compartmentalization of CRIH into four compartments catering to four loops separately. The conventional 3-element level control has been found to be working satisfactorily. The interconnections between ECCS header and inlet header compartments have also increased the safety margin for various LOCA and design basis events. The paper deals with the SD level control aspects for this novel MHT configuration which has been analyzed for various PIEs (Postulated Initiating Events) and found to be satisfactory. (orig.)

  9. Timing and motor control in drumming

    DEFF Research Database (Denmark)

    Dahl, Sofia; Grossbach, Michael; Altenmüller, Eckart

    the stick movement becomes increasingly difficult, sometimes resulting in irregularities in timing and/or striking force. Timing irregularities can also be a revealing sign of motor control problems, such as focal dystonia (Jabusch, Vauth & Altenmüller, 2004). The "breakdown" in motor control can therefore......The ability to keep a steady tempo is influenced by individual prerequisites as well as the playing conditions at hand. Percussionists have to acquire playing techniques that allow them to perform at the required tempi and dynamic levels. For more extreme tempi and dynamic levels controlling......) and dynamic levels (p, mf, f) were recorded. The motion data was analyzed with respect to general movement pattern, variability in timing and striking force. Preliminary results confirm deterioration in movement patterns for the faster tempi, typically displaying stiffened joints and lack of timing control...

  10. Fluorescence In Situ Hybridization (FISH-Based Karyotyping Reveals Rapid Evolution of Centromeric and Subtelomeric Repeats in Common Bean (Phaseolus vulgaris and Relatives

    Directory of Open Access Journals (Sweden)

    Aiko Iwata-Otsubo

    2016-04-01

    Full Text Available Fluorescence in situ hybridization (FISH-based karyotyping is a powerful cytogenetics tool to study chromosome organization, behavior, and chromosome evolution. Here, we developed a FISH-based karyotyping system using a probe mixture comprised of centromeric and subtelomeric satellite repeats, 5S rDNA, and chromosome-specific BAC clones in common bean, which enables one to unambiguously distinguish all 11 chromosome pairs. Furthermore, we applied the karyotyping system to several wild relatives and landraces of common bean from two distinct gene pools, as well as other related Phaseolus species, to investigate repeat evolution in the genus Phaseolus. Comparison of karyotype maps within common bean indicates that chromosomal distribution of the centromeric and subtelomeric satellite repeats is stable, whereas the copy number of the repeats was variable, indicating rapid amplification/reduction of the repeats in specific genomic regions. In Phaseolus species that diverged approximately 2–4 million yr ago, copy numbers of centromeric repeats were largely reduced or diverged, and chromosomal distributions have changed, suggesting rapid evolution of centromeric repeats. We also detected variation in the distribution pattern of subtelomeric repeats in Phaseolus species. The FISH-based karyotyping system revealed that satellite repeats are actively and rapidly evolving, forming genomic features unique to individual common bean accessions and Phaseolus species.

  11. Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria.

    Science.gov (United States)

    Tan, Yunhao; Zanoni, Ivan; Cullen, Thomas W; Goodman, Andrew L; Kagan, Jonathan C

    2015-11-17

    Microbe-induced receptor trafficking has emerged as an essential means to promote innate immune signal transduction. Upon detection of bacterial lipopolysaccharides (LPS), CD14 induces an inflammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes. Although several regulators of CD14-dependent TLR4 endocytosis have been identified, the cargo-selection mechanism during this process remains unknown. We reveal that, in contrast to classic cytosolic interactions that promoted the endocytosis of transmembrane receptors, TLR4 was selected as cargo for inflammatory endocytosis entirely through extracellular interactions. Mechanistically, the extracellular protein MD-2 bound to and dimerized TLR4 in order to promote this endocytic event. Our analysis of LPS variants from human pathogens and gut commensals revealed a common mechanism by which bacteria prevent inflammatory endocytosis. We suggest that evasion of CD14-dependent endocytosis is an attribute that transcends the concept of pathogenesis and might be a fundamental feature of bacteria that inhabit eukaryotic hosts.

  12. Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells

    DEFF Research Database (Denmark)

    Kirstetter, Peggy; Schuster, Mikkel B; Bereshchenko, Oksana

    2008-01-01

    Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBPalpha isoform (p...... penetrance. p42-deficient leukemia could be transferred by a Mac1+c-Kit+ population that gave rise only to myeloid cells in recipient mice. Expression profiling of this population against normal Mac1+c-Kit+ progenitors revealed a signature shared with MLL-AF9-transformed AML....

  13. Fort Drum integrated resource assessment. Volume 2, Baseline detail

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, D.R.; Armstrong, P.R.; Brodrick, J.R.; Daellenbach, K.K.; Di Massa, F.V.; Keller, J.M.; Richman, E.E.; Sullivan, G.P.; Wahlstrom, R.R.

    1992-12-01

    The US Army Forces Command (FORSCOM) has tasked the Pacific Northwest Laboratory (PNL) as the lead laboratory supporting the US Department of Energy (DOE) Federal Energy Management Program`s mission to identify, evaluate, and assist in acquiring all cost-effective energy projects at Fort Drum. This is a model program PNL is designing for federal customers served by the Niagara Mohawk Power Company. It will identify and evaluate all electric and fossil fuel cost-effective energy projects; develop a schedule at each installation for project acquisition considering project type, size, timing, and capital requirements, as well as energy and dollar savings; and secure 100% of the financing required to implement electric energy efficiency projects from Niagara Mohawk and have Niagara Mohawk procure the necessary contractors to perform detailed audits and install the technologies. This report documents the assessment of baseline energy use at one of Niagara Mohawk`s primary federal facilities, the FORSCOM Fort Drum facility located near Watertown, New York. It is a companion report to Volume 1, the Executive Summary, and Volume 3, the Resource Assessment. This analysis examines the characteristics of electric, gas, oil, propane, coal, and purchased thermal capacity use for fiscal year (FY) 1990. It records energy-use intensities for the facilities at Fort Drum by building type and energy end use. It also breaks down building energy consumption by fuel type, energy end use, and building type. A complete energy consumption reconciliation is presented that includes the accounting of all energy use among buildings, utilities, central systems, and applicable losses.

  14. Design of the control law of the steam drum boiler level taking into consideration energy economy

    Directory of Open Access Journals (Sweden)

    Juravliov A.A.

    2005-12-01

    Full Text Available The cascade system for maintaining the level in the steam boiler drum was investigated. Main features of the system are it’s variable structure which changes depending on the load variation relative to its previous value, and the use of the model of the drum level in dependence of the feedwater flow rate.

  15. A method to quantify tritium inside waste drums: He{sup 3} ingrowth method

    Energy Technology Data Exchange (ETDEWEB)

    Godot, A.; Lepeytre, C.; Hubinois, J.C. [CEA Valduc, Dept. Traitement Materiaux Nucleaires, Service Analyses- Dechets, Lab. Chimie Analytique, 21 - Is-sur-Tille (France); Arseguel, A.; Daclin, J.P.; Douche, C. [CEA Valduc, Dept. Traitement Materiaux Nucleaires, Service Analyses- Dechets, Lab. de Gestion des Dechets Trities, 21 - Is-sur-Tille (France)

    2008-07-15

    This method enables an indirect, non intrusive and non destructive measurement of the Tritium activity in wastes drums. The amount of tritium enclosed inside a wastes drum can be determined by the measurement of the leak rate of {sup 3}He of this latter. The simulation predicts that a few months are necessary for establishing the equilibrium between the {sup 3}He production inside the drum and the {sup 3}He drum leak. In practice, after one year of storage, sampling {sup 3}He outside the drum can be realized by the mean of a confining chamber that collect the {sup 3}He outflow. The apparatus, the experimental procedure and the calculation of tritium activity from mass spectrometric {sup 3}He measurements are detailed. The industrial device based on a confinement cell and the automated process to measure the {sup 3}He amount at the initial time and after the confinement time is described. Firstly, reference drums containing a certified tritium activity (HTO) in addition to organic materials have been measured to qualify the method and to evaluate its performances. Secondly, tritium activity of organic wastes drums issued from the storage building in Valduc have been determined. Results of the qualification and optimised values of the experimental parameters are reported in order to determine the performances of this industrial device. As a conclusion, the apparatus enables the measurement of an activity as low as 1 GBq of tritium in a 200 liters drum containing organic wastes. (authors)

  16. Multi-Cultural Awareness Project, the Organization and Implementation of a "World Steel Drum Ensemble".

    Science.gov (United States)

    Lawson, Stanley G.

    This proposal describes the organization and implementation of a "World Steel Drum Ensemble" as a strategy to solve the problems of low minority academic achievement, high minority discipline incidents, and minority isolationism. The drum ensemble studied and performed music from Caribbean, Hispanic, and African heritages in a middle…

  17. CSER 00-006 Storage of Plutonium Residue Containers in 55 Gallon Drums at the PFP

    Energy Technology Data Exchange (ETDEWEB)

    DOBBIN, K.D.

    2000-05-24

    This criticality safety evaluation report (CSER) provides the required limit set and controls for safe transit and storage of these drums in the 234-5Z Building at the PFP. A mass limit of 200 g of plutonium or fissile equivalent per drum is acceptable

  18. 76 FR 51314 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Adoption of Drum and...

    Science.gov (United States)

    2011-08-18

    ....11.19.13, Volatile Organic Compounds from Specific Processes, Drum and Pail Coating. Maryland's SIP revision meets the requirement to adopt Reasonably Available Control Technology (RACT) for sources covered... of Drum and Pail Coating Standards AGENCY: Environmental Protection Agency (EPA). ACTION:...

  19. Nondestructive Analysis of MET-5 Drum at TA35 Building 2 A-Wing Vault.

    Energy Technology Data Exchange (ETDEWEB)

    Desimone, David J. [Los Alamos National Laboratory; Vo, Duc Ta [Los Alamos National Laboratory

    2016-11-03

    Measurements using a mechanically cooled portable high purity germanium HPGe Ortec detective were taken of a type B drum Serial number R-1157 to determine if any radioactive material was inside. The Drum, R-1157, spectrum was analyzed using PeakEasy 4.84 and a visual look at the spectrum showed background radiation.

  20. Bringing Carnaval Drum and Dance Traditions into 4-H Programming for Latino Youth

    Science.gov (United States)

    Conklin-Ginop, Evelyn; Braverman, Marc T.; Caruso, Robyn; Bone, Dennis

    2011-01-01

    4-H Bloco Drum and Dance is an afterschool program that teaches adolescents drumming, dancing, and theater arts in the rich traditions of Brazilian Carnaval. Teens learn to express themselves in a variety of modalities and perform at community events. The program was developed by a community coalition that included 4-H, other youth programs, and…

  1. An inverse method for online stress monitoring and fatigue life analysis of boiler drums

    Institute of Scientific and Technical Information of China (English)

    HU Wen-sen; LI Bin; CAO Zi-dong; YANG Dong; LI Ya-chao

    2009-01-01

    A method based on solution of the inverse heat conduction problem was presented for online stress monitoring and fatigue life analysis of boiler drums. The mathematical model of the drum temperature distribution is based on the assumptions that the difference of temperature along the longitudinal axis of the boiler drum is negligible with changes only in the radial direction and the circumferential direction, and that the outer surface of drum is thermally insulated. Combining this model with the control-volume method provides temperatures at different points on a eross-section of the drum. With the temperature data, the stresses and the life expectancy of the boiler drum are derived according to the ASME code. Applying this method to the cold start-up process of a 300 MW boiler demonswated the absence of errors caused by the boundary condition assumptions on the inner surface of the drum and testified that the method is an applicable technique for the online stress monitoring and fatigue life analysis of boiler drums.

  2. 77 FR 2981 - Constitution Road Drum Superfund Site; Atlanta, Dekalb County, GA; Notice of Settlement

    Science.gov (United States)

    2012-01-20

    ... AGENCY Constitution Road Drum Superfund Site; Atlanta, Dekalb County, GA; Notice of Settlement AGENCY... Protection Agency has entered into a settlement for past response costs concerning the Constitution Road Drum... settlement are available from Ms. Paula V. Painter. Submit your comments by Site name Constitution Road...

  3. 佤族木鼓文化中女性身体的社会性别分析%Gender Analysis of Female Bodies in the Wooden Drum Culture of Wa People

    Institute of Scientific and Technical Information of China (English)

    马祯

    2015-01-01

    木鼓崇拜是历史上佤文化的重要内容,在佤族社会中扮演着重要角色。木鼓起源神话、木鼓形制、木鼓祭祀女神、拉木鼓仪式中猎女人头等均与女性有关。整个木鼓崇拜中女性无处不在。通过对木鼓文化的人类学分析,揭示木鼓文化背后的社会性别象征,探讨佤族社会的女性观念,进而反观社会性别研究中对女性身体的讨论。%Wooden drum worship is very important of Wa culture in history.The origin of wooden drama myths,drum shape,the sacrifice to the Goddess,hunting women in drum ceremonies were related to women.Wa peoples'drum culture was closely related to women,especially their bodies.This paper trying to reveals the concept of women and gender symbol in the wooden drum cul-ture through an anthropological perspective and,in turn,to discuss the female body in the social gen-der studies.

  4. Correlation between discharge timings of pairs of motor units reveals the presence but not the proportion of common synaptic input to motor neurons.

    Science.gov (United States)

    Rodriguez-Falces, Javier; Negro, Francesco; Farina, Dario

    2017-01-18

    We investigated whether correlation measures derived from pairs of motor unit (MU) spike trains are reliable indicators of the degree of common synaptic input to motor neurons. Several 50-s isometric contractions of the biceps brachii muscle were performed at different target forces ranging from 10 to 30% of the maximal voluntary contraction (MVC) relying on force feedback. 48 pairs of MUs were examined at various force levels. Motor unit synchrony was assessed by cross-correlation analysis using three indices: the output correlation as the peak of the cross-histogram (ρ), the number of synchronous spikes per second (CIS), and per trigger (E). Individual analysis of MU pairs revealed that ρ, CIS, and E were most often positively associated to discharge rate (87, 85, and 76% of the MU pairs, respectively) and negatively to inter-spike interval variability (69, 65, and 62% of the MU pairs, respectively). Moreover, the behaviour of synchronization indices with discharge rate (and inter-spike interval variability) varied greatly among the MU pairs. These results were consistent with theoretical predictions, which showed that the output correlation between pairs of spike trains depends on the statistics of the input current and motor neuron intrinsic properties that differ for different motor neuron pairs. In conclusion, the synchronization between MU firing trains is necessarily caused by the (functional) common input to motor neurons, but it is not possible to infer the degree of shared common input to a pair of motor neurons based on correlation measures of their output spike trains.

  5. Control of thermoacoustic instability with a drum-like silencer

    Science.gov (United States)

    Zhang, Guangyu; Wang, Xiaoyu; Li, Lei; Jing, Xiaodong; Sun, Xiaofeng

    2017-10-01

    Theoretical investigation is carried out by a novel method of controlling thermoacoustic instability with a drum-like silencer. It is shown that by decreasing the frequency of thermoacoustic system, the instability can be suppressed with the help of drum-like silencer. The purely reactive silencer, which is composed of a flexible membrane and a backing cavity, is usually known as a noise control device that works effectively in low frequency bandwidth without any aerodynamic loss. In present research, the silencer is exploited in a Rijke tube, as a means of decreasing the natural frequency of the system, and consequently changing the resonance period of the system. The ;transfer element method; (TEM) is used to consider the interactions between the acoustic waves and the flexible membranes of the silencer. The effects of all possible properties of the silencer on the growth rate and resonance frequency of the thermoacoustic system are explored. According to the calculation results, it is found that for some properties of the silencer, the resonance frequencies are greatly decreased and then the phase difference between the unsteady heat release and the pressure fluctuation is increased. Consequently, the instability is suppressed with some dissipation that can not be able to control its onset in the original system. Therefore, when the damping is low, but not zero, it is effective to control thermoacoustic instability with this technique.

  6. Validation testing of radioactive waste drum filter vents

    Energy Technology Data Exchange (ETDEWEB)

    Weber, L.D. [Pall Corp., Port Washington, NY (United States); Rahimi, R.S. [Pall Corp., Cortland, NY (United States); Edling, D. [Edling & Associates, Inc., Russel Springs, KY (United States)

    1997-08-01

    The minimum requirements for Drum Filter Vents (DFVs) can be met by demonstrating conformance with the Waste Isolation Pilot Plant (WIPP) Trupact II Safety Assessment Report (SAR), and conformance with U.S. Federal shipping regulations 49 CFR 178.350, DOT Spec 7A, for Type A packages. These together address a number of safety related performance parameters such as hydrogen diffusivity, flow related pressure drop, filtration efficiency and, separately, mechanical stability and the ability to prevent liquid water in-leakage. In order to make all metal DFV technology (including metallic filter medium) available to DOE sites, Pall launched a product development program to validate an all metal design to meet these requirements. Numerous problems experienced by DOE sites in the past came to light during this development program. They led us to explore enhancements to DFV design and performance testing addressing these difficulties and concerns. The result is a patented all metal DFV certified to all applicable regulatory requirements, which for the first time solves operational and health safety problems reported by DOE site personnel but not addressed by previous DFV`s. The new technology facilitates operations (such as manual, automated and semi-automated drum handling/redrumming), sampling, on-site storage, and shipping. At the same time, it upgrades filtration efficiency in configurations documented to maintain filter efficiency following mechanical stress. 2 refs., 2 figs., 10 tabs.

  7. Effects of Community African Drumming on Generalised Anxiety in Teenagers

    Directory of Open Access Journals (Sweden)

    David Akombo

    2013-07-01

    Full Text Available The purpose of this study was to test the effects of community music projects (CMPs, such as after-school African drumming circles, on academic performance and generalised anxiety in adolescents. Adolescents from a Junior High (7th, 8th, and 9th graders, age range from 12-14 in the State of Utah (USA participated in the study. A one-sample t-test found a significant difference in reading scores (df(4 p=.004. A paired samples t-test found a significant relationship between the maths trait anxiety score pre-intervention and the total state anxiety score pre-test (df(4 p=.033. A paired samples t-test found a significant relationship between the reading trait anxiety score post-intervention and the total state anxiety score post-test (df(4 p=.030. This research demonstrates the effectiveness of community music such as drumming for reducing anxiety and also for improving academic performance in adolescents. CMPs are recommended as a non-invasive intervention modality for adolescents.

  8. Drawing method and device of activated carbon sludge from drums

    Energy Technology Data Exchange (ETDEWEB)

    Ozaki, Shigeru [Toshiba Corp., Kawasaki, Kanagawa (Japan); Kaji, Koichi

    1998-09-11

    Upon drawing out active sludge accumulated while being separated from supernatant water in a drum for containing active sludge generated as residues after the processing of washing liquid generated in a nuclear power plant, the sludge is stirred together with the supernatant water while being scraped off from the surface by using a stirring blade equipped with teeth. Then the sludge in the form of a slurry is drained by a highly viscous fluid transferring-pump. Then accumulated active carbon sludge can be supplied quantitatively as a mayonnaise-like slurry to a furnace. Alternatively, the supernatant water is drawn out at first from a drum, and sludge is discharged to the outside next by using screw blades disposed backward while scraping the sludge from the surface by rotating scraping teeth. With such procedures, there can be provided an advantageous point that the accumulated active carbon sludge can be supplied in a state of small lumps quantitatively to a furnace. (T.M.)

  9. Reliability and maintainability analysis of electrical system of drum shearers

    Institute of Scientific and Technical Information of China (English)

    SEYED Hadi Hoseinie; MOHAMMAD Ataei; REZA Khalokakaie; UDAY Kumar

    2011-01-01

    The reliability and maintainability of electrical system of drum shearer at Parvade.l Coal Mine in central Iran was analyzed. The maintenance and failure data were collected during 19 months of shearer operation. According to trend and serial correlation tests, the data were independent and identically distributed (iid) and therefore the statistical techniques were used for modeling. The data analysis show that the time between failures (TBF) and time to repair (TTR) data obey the lognormal and Weibull 3 parameters distribution respectively. Reliability-based preventive maintenance time intervals for electrical system of the drum shearer were calculated with regard to reliability plot. The reliability-based maintenance intervals for 90%, 80%, 70% and 50% reliability level are respectively 9.91, 17.96, 27.56 and 56.1 h. Also the calculations show that time to repair (TTR) of this system varies in range 0.17-4 h with 1.002 h as mean time to repair (MTTR). There is a 80% chance that the electrical system of shearer of Parvade.l mine repair will be accomplished within 1.45 h.

  10. Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators.

    Science.gov (United States)

    Clarke, Luka A; Botelho, Hugo M; Sousa, Lisete; Falcao, Andre O; Amaral, Margarida D

    2015-11-01

    A meta-analysis of 13 independent microarray data sets was performed and gene expression profiles from cystic fibrosis (CF), similar disorders (COPD: chronic obstructive pulmonary disease, IPF: idiopathic pulmonary fibrosis, asthma), environmental conditions (smoking, epithelial injury), related cellular processes (epithelial differentiation/regeneration), and non-respiratory "control" conditions (schizophrenia, dieting), were compared. Similarity among differentially expressed (DE) gene lists was assessed using a permutation test, and a clustergram was constructed, identifying common gene markers. Global gene expression values were standardized using a novel approach, revealing that similarities between independent data sets run deeper than shared DE genes. Correlation of gene expression values identified putative gene regulators of the CF transmembrane conductance regulator (CFTR) gene, of potential therapeutic significance. Our study provides a novel perspective on CF epithelial gene expression in the context of other lung disorders and conditions, and highlights the contribution of differentiation/EMT and injury to gene signatures of respiratory disease.

  11. High-resolution mapping reveals linkage between genes in common bean cultivar Ouro Negro conferring resistance to the rust, anthracnose, and angular leaf spot diseases.

    Science.gov (United States)

    Valentini, Giseli; Gonçalves-Vidigal, Maria Celeste; Hurtado-Gonzales, Oscar P; de Lima Castro, Sandra Aparecida; Cregan, Perry B; Song, Qijian; Pastor-Corrales, Marcial A

    2017-08-01

    Co-segregation analysis and high-throughput genotyping using SNP, SSR, and KASP markers demonstrated genetic linkage between Ur-14 and Co-3 (4) /Phg-3 loci conferring resistance to the rust, anthracnose and angular leaf spot diseases of common bean. Rust, anthracnose, and angular leaf spot are major diseases of common bean in the Americas and Africa. The cultivar Ouro Negro has the Ur-14 gene that confers broad spectrum resistance to rust and the gene cluster Co-3 (4) /Phg-3 containing two tightly linked genes conferring resistance to anthracnose and angular leaf spot, respectively. We used co-segregation analysis and high-throughput genotyping of 179 F2:3 families from the Rudá (susceptible) × Ouro Negro (resistant) cross-phenotyped separately with races of the rust and anthracnose pathogens. The results confirmed that Ur-14 and Co-3 (4) /Phg-3 cluster in Ouro Negro conferred resistance to rust and anthracnose, respectively, and that Ur-14 and the Co-3 (4) /Phg-3 cluster were closely linked. Genotyping the F2:3 families, first with 5398 SNPs on the Illumina BeadChip BARCBEAN6K_3 and with 15 SSR, and eight KASP markers, specifically designed for the candidate region containing Ur-14 and Co-3 (4) /Phg-3, permitted the creation of a high-resolution genetic linkage map which revealed that Ur-14 was positioned at 2.2 cM from Co-3 (4) /Phg-3 on the short arm of chromosome Pv04 of the common bean genome. Five flanking SSR markers were tightly linked at 0.1 and 0.2 cM from Ur-14, and two flanking KASP markers were tightly linked at 0.1 and 0.3 cM from Co-3 (4) /Phg-3. Many other SSR, SNP, and KASP markers were also linked to these genes. These markers will be useful for the development of common bean cultivars combining the important Ur-14 and Co-3 (4) /Phg-3 genes conferring resistance to three of the most destructive diseases of common bean.

  12. Infrared thermography applied to monitoring of radioactive waste drums; Termografia infravermelha aplicada ao monitoramento de tambores de rejeitos radioativos

    Energy Technology Data Exchange (ETDEWEB)

    Kelmer, P.; Camarano, D.M. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Calado, F.; Phillip, B.; Viana, C.; Andrade, R.M., E-mail: paulafuziki@yahoo.com.br, E-mail: flavio.arcalado@gmail.com, E-mail: bruno.phil@gmail.com, E-mail: criisviana@hotmail.com, E-mail: rma@ufmg.br, E-mail: dmc@cdtn.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Eletrica

    2013-07-01

    The use of thermography in the inspection of drums containing radioactive waste is being stimulated by the absence of physical contact. In Brazil the majority of radioactive wastes are compacted solids packed in metal drums stored temporarily for decades and requires special attention. These drums have only one qualitative indication of the radionuclides present. However, its structural condition is not followed systematically. The aim of this work is presents a methodology by applying thermography for monitoring the structural condition of drums containing radioactive waste in order to detect degraded regions of the drums. (author)

  13. Comparative Genomic Analyses of Multiple Pseudomonas Strains Infecting Corylus avellana Trees Reveal the Occurrence of Two Genetic Clusters with Both Common and Distinctive Virulence and Fitness Traits.

    Directory of Open Access Journals (Sweden)

    Simone Marcelletti

    Full Text Available The European hazelnut (Corylus avellana is threatened in Europe by several pseudomonads which cause symptoms ranging from twig dieback to tree death. A comparison of the draft genomes of nine Pseudomonas strains isolated from symptomatic C. avellana trees was performed to identify common and distinctive genomic traits. The thorough assessment of genetic relationships among the strains revealed two clearly distinct clusters: P. avellanae and P. syringae. The latter including the pathovars avellanae, coryli and syringae. Between these two clusters, no recombination event was found. A genomic island of approximately 20 kb, containing the hrp/hrc type III secretion system gene cluster, was found to be present without any genomic difference in all nine pseudomonads. The type III secretion system effector repertoires were remarkably different in the two groups, with P. avellanae showing a higher number of effectors. Homologue genes of the antimetabolite mangotoxin and ice nucleation activity clusters were found solely in all P. syringae pathovar strains, whereas the siderophore yersiniabactin was only present in P. avellanae. All nine strains have genes coding for pectic enzymes and sucrose metabolism. By contrast, they do not have genes coding for indolacetic acid and anti-insect toxin. Collectively, this study reveals that genomically different Pseudomonas can converge on the same host plant by suppressing the host defence mechanisms with the use of different virulence weapons. The integration into their genomes of a horizontally acquired genomic island could play a fundamental role in their evolution, perhaps giving them the ability to exploit new ecological niches.

  14. Active source requirements for assay of sludge drums on the BIR WIT system

    Energy Technology Data Exchange (ETDEWEB)

    Roberson, G.P.; Camp, D.C.

    1998-04-27

    The design of the active source for active and passive computed tomography (A&PCT) is critical with respect to accuracy and throughput. The A&PCT active source requirements are highly dependent upon the attenuation properties of the waste matrix within the drum. On of the most highly attenuating waste matrices is sludge. This waste stream will consist of solidified aqueous waste consisting of IDC 001 first stage sludge and IDC 007 wet sludge. Also, the stream consists of solidified organic waste known as code IDC 003 organic setups. We have evaluated the sludge drum data that was previously acquired on the WIT system and have determined that the active source activity must be increased to provide reasonable throughput. The sludge drum that is evaluated here is drum CEPRF11. CEPRF11 is a test drum that was part of the Nondestructive Assay system Capability Evaluation Project (CEP) and contained an actual Rocky Flats waste that is categorized as code 003 solidified organic waste. The full drum was evaluated and found to be somewhat homogenous; therefore, a single slice is arbitrarily chosen to represent the entire drum. Slice number 8 is used and is located approximately at the center of the drum. Figure 1 shows the averaged projections for different energies derived from the active sinogram of slice number 8 from the CEPRF11 drum. This is the average of all the projections of slice 8 taken over 180 degrees with an active integration time of 6 seconds. Figure 2 is also a graph showing the average of all the projections for slice 8; however, the active integration time is 30 seconds.

  15. A Markov chain analysis of the effectiveness of drum-buffer-rope material flow management in job shop environment

    Directory of Open Access Journals (Sweden)

    Masoud Rabbani

    2015-09-01

    Full Text Available The theory of constraints is an approach for production planning and control, which emphasizes on the constraints in the system to increase throughput. The theory of constraints is often referred to as Drum-Buffer-Rope developed originally by Goldratt. Drum-Buffer-Rope uses the drum or constraint to create a schedule based on the finite capacity of the first bottleneck. Because of complexity of the job shop environment, Drum-Buffer-Rope material flow management has very little attention to job shop environment. The objective of this paper is to apply the Drum-Buffer-Rope technique in the job shop environment using a Markov chain analysis to compare traditional method with Drum-Buffer-Rope. Four measurement parameters were considered and the result showed the advantage of Drum-Buffer-Rope approach compared with traditional one.

  16. Framing the Question: Learning How to Learn from the Drum

    Directory of Open Access Journals (Sweden)

    Robert Stephens

    2015-07-01

    Full Text Available In this essay, I explore the dimensions of my experiences as an initiated member of Omo-aña, consecrated players of the Afro-Cuban sacred batá drum, an instrument that originated in Yorubaland in Nigeria, West Africa, and traveled to Cuba in the 1800s. I will describe the evolving process of learning to play the batá under the guidance of one of the most influential Olubata—keepers of the sacred batá—in the United States, my cultural consultant, Orlando “Puntilla” Rios.  The guiding question is: How can I use frame analysis as a tool in thinking about my own learning process, and by extension, to deconstruct the dominant frames to illuminate a broader range of alternatives?

  17. The Telescope Array Middle Drum fluorescence detector simulation on GPUs

    Science.gov (United States)

    Abu-Zayyad, Tareq; Telescope-Array Collaboration

    2014-06-01

    In recent years, the Graphics Processing Unit (GPU) has been recognized and widely used as an accelerator for many scientific calculations. In general, problems amenable to parallelization are ones that benefit most from the use of GPUs. The Monte Carlo simulation of fluorescence detector response to air showers presents many opportunities for parallelization. In this paper we report on a Monte Carlo program used for the simulation of the Telescope Array Fluorescence Detector located at the Middle Drum site which uses GPU acceleration. All of the physics simulation from shower development, light production and atmospheric attenuation, as well as, the realistic detector optics and electronics simulations are done on the GPU. A detailed description of the code implementation is given, and results on the accuracy and performance of the simulation are presented as well. Improvements in computational throughput in excess of 50× are reported and the accuracy of the results is on par with the CPU implementation of the simulation.

  18. Passive neutron design study for 200-L waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Menlove, H.O.; Beddingfield, D.B.; Pickrell, M.M. [and others

    1997-09-01

    We have developed a passive neutron counter for the measurement of plutonium in 200-L drums of scrap and waste. The counter incorporates high efficiency for the multiplicity counting in addition to the traditional coincidence counting. The {sup 252}Cf add-a-source feature is used to provide an accurate assay over a wide range of waste matrix materials. The room background neutron rate is reduced by using 30 cm of external polyethylene shielding and the cosmic-ray background is reduced by statistical filtering techniques. Monte Carlo Code calculations were used to determine the optimum detector design, including the gas pressure, size, number, and placement of the {sup 3}He tubes in the moderator. Various moderators, including polyethylene, plastics, teflon, and graphite, were evaluated to obtain the maximum efficiency and minimum detectable mass of plutonium.

  19. Dynamic simulation of flash drums using rigorous physical property calculations

    Directory of Open Access Journals (Sweden)

    F. M. Gonçalves

    2007-06-01

    Full Text Available The dynamics of flash drums is simulated using a formulation adequate for phase modeling with equations of state (EOS. The energy and mass balances are written as differential equations for the internal energy and the number of moles of each species. The algebraic equations of the model, solved at each time step, are those of a flash with specified internal energy, volume and mole numbers (UVN flash. A new aspect of our dynamic simulations is the use of direct iterations in phase volumes (instead of pressure for solving the algebraic equations. It was also found that an iterative procedure previously suggested in the literature for UVN flashes becomes unreliable close to phase boundaries and a new alternative is proposed. Another unusual aspect of this work is that the model expressions, including the physical properties and their analytical derivatives, were quickly implemented using computer algebra.

  20. Drum silencer with shallow cavity filled with helium.

    Science.gov (United States)

    Choy, Y S; Huang, Lixi

    2003-09-01

    The motivation of this study is twofold: (a) to produce a flow-through silencer with zero pressure loss for pressure-critical applications, and (b) to tackle low frequency noise with limited sideway space using cavities filled with helium. The work represents a further development of our recently conceived device of a drum-like silencer with conventional air cavity [Huang, J. Acoust. Soc. Am. 112, 2014-2025 (2002); Choy and Huang, ibid. 112, 2026-2035 (2002)]. Theoretical predictions are validated by experimental data. The new silencer consists of two highly tensioned membranes lining part of a duct, and each membrane is backed by a cavity filled with helium. For a typical configuration of a duct with height h, membrane length L = 7h, cavity depth h = 0.2h, and tension T = 0.52rho0c0(2)h2, where rho0 and c0 are the ambient density and speed of sound in air, respectively, the transmission loss has a continuous stop band of TL > 6.35 dB for frequency 0.03c0/h to 0.064c0/h, which is much better than traditional duct lining. In addition to the mechanisms at work for drum silencers with air cavity, the low density of helium reduces the masslike reactance of the cavity on the second in vacuo mode of membrane vibration. The reduction greatly enhances the membrane response at this mode, which is found to be critical for achieving a broadband performance in the low-frequency regime.

  1. Analysis of resistance to loading by a helical cutting drum of a shearer loader

    Energy Technology Data Exchange (ETDEWEB)

    Matyja, S.; Krauze, K.

    1977-01-01

    This report analyzes coal handling by helical cutting drums on a shearer loader. Formulae which describe effects of drum specifications on coal resistance to loading are derived. Loads on the cutting drums associated with coal resistance to loading are calculated. Analyses show that with growing haulage speed and constant cutting speed, coal resistance to loading also increases. Under conditions of constant haulage speed, increasing cutting speed causes a decrease in coal resistance to loading. Performance tests show that loading moment amounts to 13-60% of the cutting moment. Higher cutting speeds correspond with lower loading moment. Recommendations for design of shearer loaders and optimum mining schemes are made. 5 refs.

  2. Analysis of load variations on drums with three to four rows of cutting tools

    Energy Technology Data Exchange (ETDEWEB)

    Krauze, K. (Akademia Gorniczo-Hutnicza, Cracow (Poland). Instytut Maszyn Gorniczych Przerobczych i Automatyki)

    1989-11-01

    Comparatively evaluates types of shearer loaders used for longwall mining of black coal in Poland. The following data are discussed: type, web size, rated power of motors, cutter motors, haulage speed, diameter of the cutting drums, revolution rate, cutting rate. Eleven types of shearer loaders with one or two cutting drums are reviewed. Factors that influence load variations on the cutting drums are analyzed: number and arrangement of rows of cutting tools, number of cutting tools in one row, angle of cutting tool attack, cutting tool design and geometry. Curves that describe load variations and factors that influence them are plotted. 1 ref.

  3. Unconventional microarray design reveals the response to obesity is largely tissue specific: analysis of common and divergent responses to diet-induced obesity in insulin-sensitive tissues.

    Science.gov (United States)

    Lee, Robyn K; Hittel, Dustin S; Nyamandi, Vongai Z; Kang, Li; Soh, Jung; Sensen, Christoph W; Shearer, Jane

    2012-04-01

    Obesity is a chronic condition involving the excessive accumulation of adipose tissue that adversely affects all systems in the body. The aim of the present study was to employ an unbiased, genome-wide assessment of transcript abundance in order to identify common gene expression pathways within insulin-sensitive tissues in response to dietary-induced diabetes. Following 20 weeks of chow or high-fat feeding (60% kcal), age-matched mice underwent a euglycemic-hyperinsulinemic clamp to assess insulin sensitivity. High-fat-fed animals were obese and highly insulin resistant, disposing of ∼75% less glucose compared with their chow-fed counterparts. Tissues were collected, and gene expression was examined by microarray in 4 tissues known to exhibit obesity-related metabolic disturbances: white adipose tissue, skeletal muscle, liver, and heart. A total of 463 genes were differentially expressed between diets. Analysis of individual tissues showed skeletal muscle to exhibit the largest number of differentially expressed genes (191) in response to high-fat feeding, followed by adipose tissue (169), liver (115), and heart (65). Analyses revealed that the response of individual genes to obesity is distinct and largely tissue specific, with less than 10% of transcripts being shared among tissues. Although transcripts are largely tissue specific, a systems approach shows numerous commonly activated pathways, including those involved in signal transduction, inflammation, oxidative stress, substrate transport, and metabolism. This suggests a coordinated attempt by tissues to limit metabolic perturbations occurring in early-stage obesity. Many identified genes were associated with a variety of disorders, thereby serving as potential links between obesity and its related health risks.

  4. De Novo Transcriptome Analysis of the Common New Zealand Stick Insect Clitarchus hookeri (Phasmatodea Reveals Genes Involved in Olfaction, Digestion and Sexual Reproduction.

    Directory of Open Access Journals (Sweden)

    Chen Wu

    Full Text Available Phasmatodea, more commonly known as stick insects, have been poorly studied at the molecular level for several key traits, such as components of the sensory system and regulators of reproduction and development, impeding a deeper understanding of their functional biology. Here, we employ de novo transcriptome analysis to identify genes with primary functions related to female odour reception, digestion, and male sexual traits in the New Zealand common stick insect Clitarchus hookeri (White. The female olfactory gene repertoire revealed ten odorant binding proteins with three recently duplicated, 12 chemosensory proteins, 16 odorant receptors, and 17 ionotropic receptors. The majority of these olfactory genes were over-expressed in female antennae and have the inferred function of odorant reception. Others that were predominantly expressed in male terminalia (n = 3 and female midgut (n = 1 suggest they have a role in sexual reproduction and digestion, respectively. Over-represented transcripts in the midgut were enriched with digestive enzyme gene families. Clitarchus hookeri is likely to harbour nine members of an endogenous cellulase family (glycoside hydrolase family 9, two of which appear to be specific to the C. hookeri lineage. All of these cellulase sequences fall into four main phasmid clades and show gene duplication events occurred early in the diversification of Phasmatodea. In addition, C. hookeri genome is likely to express γ-proteobacteria pectinase transcripts that have recently been shown to be the result of horizontal transfer. We also predicted 711 male terminalia-enriched transcripts that are candidate accessory gland proteins, 28 of which were annotated to have molecular functions of peptidase activity and peptidase inhibitor activity, two groups being widely reported to regulate female reproduction through proteolytic cascades. Our study has yielded new insights into the genetic basis of odour detection, nutrient digestion

  5. A comparison of two common sample preparation techniques for lipid and fatty acid analysis in three different coral morphotypes reveals quantitative and qualitative differences.

    Science.gov (United States)

    Conlan, Jessica A; Rocker, Melissa M; Francis, David S

    2017-01-01

    Lipids are involved in a host of biochemical and physiological processes in corals. Therefore, changes in lipid composition reflect changes in the ecology, nutrition, and health of corals. As such, accurate lipid extraction, quantification, and identification is critical to obtain comprehensive insight into a coral's condition. However, discrepancies exist in sample preparation methodology globally, and it is currently unknown whether these techniques generate analogous results. This study compared the two most common sample preparation techniques for lipid analysis in corals: (1) tissue isolation by air-spraying and (2) crushing the coral in toto. Samples derived from each preparation technique were subsequently analysed to quantify lipids and their constituent classes and fatty acids in four common, scleractinian coral species representing three distinct morphotypes (Acropora millepora, Montipora crassotuberculata, Porites cylindrica, and Pocillopora damicornis). Results revealed substantial amounts of organic material, including lipids, retained in the skeletons of all species following air-spraying, causing a marked underestimation of total lipid concentration using this method. Moreover, lipid class and fatty acid compositions between the denuded skeleton and sprayed tissue were substantially different. In particular, the majority of the total triacylglycerol and total fatty acid concentrations were retained in the skeleton (55-69% and 56-64%, respectively). As such, the isolated, sprayed tissue cannot serve as a reliable proxy for lipid quantification or identification in the coral holobiont. The in toto crushing method is therefore recommended for coral sample preparation prior to lipid analysis to capture the lipid profile of the entire holobiont, permitting accurate diagnoses of coral condition.

  6. Beyond the word and image: characteristics of a common meaning system for language and vision revealed by functional and structural imaging.

    Science.gov (United States)

    Jouen, A L; Ellmore, T M; Madden, C J; Pallier, C; Dominey, P F; Ventre-Dominey, J

    2015-02-01

    This research tests the hypothesis that comprehension of human events will engage an extended semantic representation system, independent of the input modality (sentence vs. picture). To investigate this, we examined brain activation and connectivity in 19 subjects who read sentences and viewed pictures depicting everyday events, in a combined fMRI and DTI study. Conjunction of activity in understanding sentences and pictures revealed a common fronto-temporo-parietal network that included the middle and inferior frontal gyri, the parahippocampal-retrosplenial complex, the anterior and middle temporal gyri, the inferior parietal lobe in particular the temporo-parietal cortex. DTI tractography seeded from this temporo-parietal cortex hub revealed a multi-component network reaching into the temporal pole, the ventral frontal pole and premotor cortex. A significant correlation was found between the relative pathway density issued from the temporo-parietal cortex and the imageability of sentences for individual subjects, suggesting a potential functional link between comprehension and the temporo-parietal connectivity strength. These data help to define a "meaning" network that includes components of recently characterized systems for semantic memory, embodied simulation, and visuo-spatial scene representation. The network substantially overlaps with the "default mode" network implicated as part of a core network of semantic representation, along with brain systems related to the formation of mental models, and reasoning. These data are consistent with a model of real-world situational understanding that is highly embodied. Crucially, the neural basis of this embodied understanding is not limited to sensorimotor systems, but extends to the highest levels of cognition, including autobiographical memory, scene analysis, mental model formation, reasoning and theory of mind. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Phylogenetic analysis of spring virema of carp virus reveals distinct subgroups with common origins for recent isolates in North America and the UK.

    Science.gov (United States)

    Miller, O; Fuller, F J; Gebreyes, W A; Lewbart, G A; Shchelkunov, I S; Shivappa, R B; Joiner, C; Woolford, G; Stone, D M; Dixon, P F; Raley, M E; Levine, J F

    2007-07-16

    Genetic relationships between 35 spring viremia of carp virus (SVCV) genogroup Ia isolates were determined based on the nucleotide sequences of the phosphoprotein (P) gene and glycoprotein (G) genes. Phylogenetic analysis based on P gene sequences revealed 2 distinct subgroups within SVCV genogroup Ia, designated SVCV Iai and Iaii, and suggests at least 2 independent introductions of the virus into the USA in 2002. Combined P- and G-sequence data support the emergence of SVCV in Illinois, USA, and in Lake Ontario, Canada, from the initial outbreak in Wisconsin, USA, and demonstrate a close genetic link to viruses isolated during routine import checks on fish brought into the UK from Asia. The data also showed a genetic link between SVCV isolations made in Missouri and Washington, USA, in 2004 and the earlier isolation made in North Carolina, USA, in 2002. However, based on the close relationship to a 2004 UK isolate, the data suggest than the Washington isolate represents a third introduction into the US from a common source, rather than a reemergence from the 2002 isolate. There was strong phylogenetic support for an Asian origin for 9 of 16 UK viruses isolated either from imported fish, or shown to have been in direct contact with fish imported from Asia. In one case, there was 100% nucleotide identity in the G-gene with a virus isolated in China.

  8. Large scale fusion of gray matter and resting-state functional MRI reveals common and shared biological markers across the psychosis spectrum in the B-SNIP cohort

    Directory of Open Access Journals (Sweden)

    Zheng eWang

    2015-12-01

    Full Text Available To investigate whether aberrant interactions between brain structure and function present similarly or differently across probands with psychotic illnesses (schizophrenia (SZ, schizoaffective disorder (SAD, and bipolar I disorder with psychosis (BP and whether these deficits are shared with their first-degree non-psychotic relatives. A total of 1199 subjects were assessed, including 220 SZ, 147 SAD, 180 psychotic BP, 150 first-degree relatives of SZ, 126 SAD relatives, 134 BP relatives and 242 healthy controls. All subjects underwent structural MRI (sMRI and resting-state functional MRI (rs-fMRI scanning. Joint independent analysis (jICA was used to fuse sMRI gray matter (GM and rs-fMRI amplitude of low frequency fluctuations (ALFF data to identify the relationship between the two modalities. Joint ICA revealed two significantly fused components. The association between functional brain alteration in a prefrontal-striatal-thalamic-cerebellar network and structural abnormalities in the default mode network (DMN was found to be common across psychotic diagnoses and correlated with cognitive function, social function and Schizo-Bipolar Scale (SBS scores. The fused alteration in the temporal lobe was unique to SZ and SAD. The above effects were not seen in any relative group (including those with cluster-A personality. Using a multivariate fused approach involving two widely used imaging markers we demonstrate both shared and distinct biological traits across the psychosis spectrum. Further, our results suggest that the above traits are psychosis biomarkers rather than endophenotypes.

  9. Forensic STR loci reveal common genetic ancestry of the Thai-Malay Muslims and Thai Buddhists in the deep Southern region of Thailand.

    Science.gov (United States)

    Kutanan, Wibhu; Kitpipit, Thitika; Phetpeng, Sukanya; Thanakiatkrai, Phuvadol

    2014-12-01

    Among the people living in the five deep Southern Thai provinces, Thai-Malay Muslims (MUS) constitute the majority, while the remaining are Thai Buddhists (BUD). Cultural, linguistic and religious differences between these two populations have been previously reported. However, their biological relationship has never been investigated. In this study, we aimed to reveal the genetic structure and genetic affinity between MUS and BUD by analyzing 15 autosomal short tandem repeats. Both distance and model-based clustering methods showed significant genetic homogeneity between these two populations, suggesting a common biological ancestry. After Islamization in this region during the fourteenth century AD, gradual albeit nonstatistically significant genetic changes occurred within these two populations. Cultural barriers possibly influenced these genetic changes. MUS have closer admixture to Malaysian-Malay Muslims than BUD countrywide. Admixture proportions also support certain degree of genetic dissimilarity between the two studied populations, as shown by the unequal genetic contribution from Malaysian-Malay Muslims. Cultural transformation and recent minor genetic admixture are the likely processes that shaped the genetic structure of both MUS and BUD.

  10. Intra- and interchromosomal rearrangements between cowpea [Vigna unguiculata (L.) Walp.] and common bean (Phaseolus vulgaris L.) revealed by BAC-FISH.

    Science.gov (United States)

    Vasconcelos, Emanuelle Varão; de Andrade Fonsêca, Artur Fellipe; Pedrosa-Harand, Andrea; de Andrade Bortoleti, Kyria Cilene; Benko-Iseppon, Ana Maria; da Costa, Antônio Félix; Brasileiro-Vidal, Ana Christina

    2015-06-01

    Cowpea (Vigna unguiculata) is an annual legume grown in tropical and subtropical regions, which is economically relevant due to high protein content in dried beans, green pods, and leaves. In this work, a comparative cytogenetic study between V. unguiculata and Phaseolus vulgaris (common bean) was conducted using BAC-FISH. Sequences previously mapped in P. vulgaris chromosomes (Pv) were used as probes in V. unguiculata chromosomes (Vu), contributing to the analysis of macrosynteny between both legumes. Thirty-seven clones from P. vulgaris 'BAT93' BAC library, corresponding to its 11 linkage groups, were hybridized in situ. Several chromosomal rearrangements were identified, such as translocations (between BACs from Pv1 and Pv8; Pv2 and Pv3; as well as Pv2 and Pv11), duplications (BAC from Pv3), as well as paracentric and pericentric inversions (BACs from Pv3, and Pv4, respectively). Two BACs (from Pv2 and Pv7), which hybridized at terminal regions in almost all P. vulgaris chromosomes, showed single-copy signal in Vu. Additionally, 17 BACs showed no signal in V. unguiculata chromosomes. The present results demonstrate the feasibility of using BAC libraries in comparative chromosomal mapping and karyotype evolution studies between Phaseolus and Vigna species, and revealed several macrosynteny and collinearity breaks among both legumes.

  11. On Inaudible Properties of Broken Drums - Isospectral Domains with Mixed Boundary Conditions

    CERN Document Server

    Herbrich, Peter

    2011-01-01

    Since Kac raised the question "Can one hear the shape of a drum?", various families of non-smooth counterexamples have been constructed using the transplantation method, which is based on a group-theoretic technique by Sunada. We apply the transplantation method to domains with mixed boundary conditions, which can be interpreted as broken drums. The method is translated into graph theory which allows for a computer-aided search for transplantable pairs, and a classification in terms of induced representations. Several tools are developed with which new pairs can be generated from given ones. In the end, we discuss inaudible properties and present the first example of a connected drum that sounds disconnected, and of a broken drum that sounds unbroken, that is, a planar domain with mixed boundary conditions that is isospectral to a domain with Dirichlet boundary conditions. Above all, the latter example shows that an orbifold can be Dirichlet isospectral to a manifold. The appendix contains several transplanta...

  12. Effectiveness of Using Floating Drum Bio-Digester to Treat Domestic ...

    African Journals Online (AJOL)

    Effectiveness of Using Floating Drum Bio-Digester to Treat Domestic Sewage. ... was incorporated at the top of the dome-shaped gas holder to control the gas flow. ... Health Organisation (WHO, 2006) standards for safe disposal of wastewater.

  13. Plasma Glucose Levels for Red Drum Sciaenops Ocellatus in a Florida Estuarine Fisheries Reserve

    Science.gov (United States)

    Bourtis, Carla M.; Francis-Floyd, Ruth; Boggs, Ashley S P.; Reyier, Eric A.; Stolen, Eric D.; Yanong, Roy P.; Guillette, Louis J., Jr.

    2015-01-01

    Despite the significant value of the southeastern United States' red drum (Sciaenops ocellatus) fishery, there is a lack of clinical blood chemistry data. This was the first study to assess plasma glucose values as an indicator of stress response to evaluate variation and the effect of reproductive activity for wild adult red drum in Florida. Red drum (n=126) were collected from NASA's Kennedy Space Center waters during three reproductive periods in 2011. Samples were obtained from the branchial vessels of the gill arch. Plasma glucose levels were significantly different among reproductive periods, with the highest mean values recorded during the spawning period, September- October (38.23 mg / dL +/- 10.0). The glucose range was 17 - 69 mg / dL. Glucose values were lower during all three periods than previous values recorded for cultured or captive red drum studies. This may indicate that fish from this population were under less stress than other populations previously sampled.

  14. Ruffed Grouse Drumming Survey Nulhegan Basin Division Silvio O. Conte National Wildlife Refuge 2004

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This presents the results of two separate Ruffed Grouse drumming survey routes conducted in May of 2004 on the Nulhegan Basin of the Silvio O. Conte National...

  15. 40 CFR 417.180 - Applicability; description of the manufacture of drum dried detergents subcategory.

    Science.gov (United States)

    2010-07-01

    ... dried detergents to powders or flakes, and packaging of finished products. ... manufacture of drum dried detergents subcategory. 417.180 Section 417.180 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING...

  16. Ruffed Grouse Drumming Survey Nulhegan Basin Division Silvio O. Conte National Wildlife Refuge 2003

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This presents the results of two separate Ruffed Grouse drumming survey routes conducted in May of 2003 on the Nulhegan Basin of the Silvio O. Conte National...

  17. Ruffed Grouse Drumming Survey Nulhegan Basin Division Silvio O. Conte National Wildlife Refuge 2006

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This presents the results of two separate Ruffed Grouse drumming survey routes conducted in May of 2006 on the Nulhegan Basin of the Silvio O. Conte National...

  18. Ruffed Grouse Drumming Survey Nulhegan Basin Division Silvio O. Conte National Wildlife Refuge 2005

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This presents the results of two separate Ruffed Grouse drumming survey routes conducted in May of 2005 on the Nulhegan Basin of the Silvio O. Conte National...

  19. Ruffed Grouse Drumming Survey Nulhegan Basin Division Silvio O. Conte National Wildlife Refuge 2002

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This presents the results of two separate Ruffed Grouse drumming survey routes conducted in May of 2002 on the Nulhegan Basin of the Silvio O. Conte National...

  20. Ruffed Grouse Drumming Survey Nulhegan Basin Division Silvio O. Conte National Wildlife Refuge 2007

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This presents the results of two separate Ruffed Grouse drumming survey routes conducted in May of 2007 on the Nulhegan Basin of the Silvio O. Conte National...

  1. Specialist bees collect Asteraceae pollen by distinctive abdominal drumming (Osmia) or brushing (Melissodes, Svastra)

    Science.gov (United States)

    Four species of western US Osmia (Cephalosmia) bees that are Asteraceae specialists (oligoleges) were observed to employ a heretofore unappreciated, stereotypical means of collecting pollen, abdominal drumming, to gather pollen from 19 flowering species representing nine tribes of Asteraceae. Abdom...

  2. Identification of the fast and thermal neutron characteristics of transuranic waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Storm, B.H. Jr.; Bramblett, R.L. [Lockheed Martin Specialty Components, Largo, FL (United States); Hensley, C. [Oak Ridge National Lab., TN (United States)

    1997-11-01

    Fissile and spontaneously fissioning material in transuranic waste drums can be most sensitively assayed using an active and passive neutron assay system such as the Active Passive Neutron Examination and Assay. Both the active and the passive assays are distorted by the presence of the waste matrix and containerization. For accurate assaying, this distortion must be characterized and accounted for. An External Matrix Probe technique has been developed that accomplishes this task. Correlations between in-drum neutron flux measurements and monitors in the Active Passive Neutron Examination and Assay chamber with various matrix materials provide a non-invasive means of predicting the thermal neutron flux in waste drums. Similarly, measures of the transmission of fast neutrons emitted from sources in the drum. Results obtained using the Lockheed Martin Specialty Components Active Passive Neutron Examination and Assay system are discussed. 12 figs., 1 tab.

  3. Selection Study of the Drive System for Toothed Drum Mixer%齿式圆筒混合机传动系统选型探讨

    Institute of Scientific and Technical Information of China (English)

    程波; 朱旭甫; 李书磊

    2014-01-01

    目前,齿式圆筒混合机的市场占有率越来越高,传动系统作为动力来源,其选型就显得十分重要。齿式圆筒混合机的传动系统形式多样,不同形式有不同的特点。经过市场调研,主要介绍了几种常见的传动形式,为齿式圆筒混合机传动系统的选型提供参考。%At the present , the market share of the toothed drum mixer is increasingly high .The drive sys-tem is power source , the selection of the drive system is very important .The type of the toothed drum mixer drive system is multifarious , and different type has different characteristics .Through market researching , this paper intro-duced some common drive types , offering reference for the selection of the toothed drum mixer drive system .

  4. Analysis of dashpot performance for rotating control drums of a lithium cooled fast reactor concept

    Science.gov (United States)

    Wenzler, C. J.

    1972-01-01

    A dashpot was incorporated in the design of the drive train of the rotating control drum to prevent shock damage to the control drum and drive train at the termination of a scram action. A rotating vane dashpot using reactor coolant lithium as a damping fluid appears to be the best candidate of the various damping devices explored. A performance analysis, results and discussion of vane type dashpots are presented.

  5. Reconstruction of the isotope activity content of heterogeneous nuclear waste drums.

    Science.gov (United States)

    Krings, Thomas; Mauerhofer, Eric

    2012-07-01

    Radioactive waste must be characterized in order to verify its conformance with national regulations for intermediate storage or its disposal. Segmented gamma scanning (SGS) is a most widely applied non-destructive analytical technique for the characterization of radioactive waste drums. The isotope specific activity content is generally calculated assuming a homogeneous matrix and activity distribution for each measured drum segment. However, real radioactive waste drums exhibit non-uniform isotope and density distributions most affecting the reliability and accuracy of activities reconstruction in SGS. The presence of internal shielding structures in the waste drum contributes generally to a strong underestimation of the activity and this in particular for radioactive sources emitting low energy gamma-rays independently of their spatial distribution. In this work we present an improved method to quantify the activity of spatially concentrated gamma-emitting isotopes (point sources or hot spots) in heterogeneous waste drums with internal shielding structures. The isotope activity is reconstructed by numerical simulations and fits of the angular dependent count rate distribution recorded during the drum rotation in SGS using an analytical expression derived from a geometric model. First results of the improved method and enhancements of this method are shown and are compared to each other as well as to the conventional method which assumes a homogeneous matrix and activity distribution. It is shown that the new model improves the accuracy and the reliability of the activity reconstruction in SGS and that the presented algorithm is suitable with respect to the framework requirement of industrial application.

  6. Design and Characterization of a Novel Rotating Corrugated Drum Reactor for Wastewater Treatment

    Directory of Open Access Journals (Sweden)

    Sarah M. Meunier

    2010-01-01

    Full Text Available A novel photoreactor system consisting of a TiO2-coated corrugated drum and a UV light source is experimentally characterized for the treatment of phenol-polluted wastewaters. The design incorporates periodic illumination and increased agitation through the introduction of rotation. The effects ofrent degrees and flat fins to increase surface area, varying rotational speed, initial pollutant concentration, and illumination intensities were studied. The corrugated and finned drums did not exhibit a critical rotational speed, indicating that there is excellent mass transfer in the system. A Langmuir-Hinshelwood kinetic analysis was applied to the degradation, and an average adsorption coefficient of K=0.120 L/mg was observed. The overall reaction rate increased with increasing surface area from 0.046 mg/L/min for the annular drum to 0.16 mg/L/min for the 40-fin drum. The apparent photonic efficiency was found to increase with increasing surface area at a faster rate for the corrugations than for the fin additions. The energy efficiency (EE/O found for the drums varied from 380–550 kWh/m3, which is up to 490% more energy-efficient than the annular drum.

  7. Influence of the Drum Position Parameters and the Ranging Arm Thickness on the Coal Loading Performance

    Directory of Open Access Journals (Sweden)

    Kuidong Gao

    2015-10-01

    Full Text Available The poor coal loading performance of a shearer drum primarily restricts the widespread application of the shearer and affects the mining efficiency in thin seam mining. The coal loading performance of the shearer drum is influenced by several factors, such as geographical environment, drum structural parameters, and motion parameters. In addition to the above factors, in the actual production, the coal loading performance of the shearer drum is also affected significantly by the drum position parameters and the structural parameters of the connected equipment, e.g., the thickness of the ranging arm. The influence of the parameters on the coal loading performance of the shearer drum was studied using a three-dimensional (3D discrete element method (DEM simulation in the current study, and the trends of the influential parameters were obtained. Therefore, the results of this study can provide technical guidance for thin seam shearer structural design, associated equipment selection, and mining technology selection, thus improving the mining efficiency and reducing the labor cost.

  8. Model test of helical angle effect on coal loading performance of shear drum

    Institute of Scientific and Technical Information of China (English)

    Kuidong Gao; Changlong Du; Songyong Liu; Lin Fu

    2012-01-01

    The work presented in this paper focuses on improving coal loading performance of shear drum.Employing the similarity theory,we carried out a dimensional analysis of the correlation parameters which influence coal loading performance of shear drum.On the basis of similarity criterion,proportional relationship between the model and the prototype was taken on the condition of taking 1/3 as the similarity coefficient.Besides taking 1600 mm drum as the prototype,four helical angle models of shearer drums (15°,18°,21°,24°) were developed.Simultaneously,based on an established cutting test-bed,coal loading performance tests for the four drums were carried out at the same drum rotational and haulage speeds.After analyzing the data of coal-loading performance and torque,we concluded that:both the coal loading performance and torque vary along the track of the parabola with the opening side facing downwards;the best coal loading performance arises when the helical angle is at 19.3°,while the biggest torque arises at 22.1°;and the coal loading performance had nonlinear relationship with the torque.

  9. Bonobo anatomy reveals stasis and mosaicism in chimpanzee evolution, and supports bonobos as the most appropriate extant model for the common ancestor of chimpanzees and humans

    National Research Council Canada - National Science Library

    Rui Diogo; Julia L Molnar; Bernard Wood

    2017-01-01

    .... Moreover, since the common chimpanzee-bonobo split c.2 Ma there have been no changes in bonobos, so with respect to HN-FL musculature bonobos are the better model for the last common ancestor (LCA...

  10. Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events.

    Directory of Open Access Journals (Sweden)

    Xianxin Li

    Full Text Available BACKGROUND: Genome-wide gene expression profile using deep sequencing technologies can drive the discovery of cancer biomarkers and therapeutic targets. Such efforts are often limited to profiling the expression signature of either mRNA or microRNA (miRNA in a single type of cancer. METHODOLOGY: Here we provided an integrated analysis of the genome-wide mRNA and miRNA expression profiles of three different genitourinary cancers: carcinomas of the bladder, kidney and testis. PRINCIPAL FINDINGS: Our results highlight the general or cancer-specific roles of several genes and miRNAs that may serve as candidate oncogenes or suppressors of tumor development. Further comparative analyses at the systems level revealed that significant aberrations of the cell adhesion process, p53 signaling, calcium signaling, the ECM-receptor and cell cycle pathways, the DNA repair and replication processes and the immune and inflammatory response processes were the common hallmarks of human cancers. Gene sets showing testicular cancer-specific deregulation patterns were mainly implicated in processes related to male reproductive function, and general disruptions of multiple metabolic pathways and processes related to cell migration were the characteristic molecular events for renal and bladder cancer, respectively. Furthermore, we also demonstrated that tumors with the same histological origins and genes with similar functions tended to group together in a clustering analysis. By assessing the correlation between the expression of each miRNA and its targets, we determined that deregulation of 'key' miRNAs may result in the global aberration of one or more pathways or processes as a whole. CONCLUSIONS: This systematic analysis deciphered the molecular phenotypes of three genitourinary cancers and investigated their variations at the miRNA level simultaneously. Our results provided a valuable source for future studies and highlighted some promising genes, mi

  11. Systematic analysis of phloem-feeding insect-induced transcriptional reprogramming in Arabidopsis highlights common features and reveals distinct responses to specialist and generalist insects.

    Science.gov (United States)

    Foyer, Christine H; Verrall, Susan R; Hancock, Robert D

    2015-02-01

    Phloem-feeding insects (PFIs), of which aphids are the largest group, are major agricultural pests causing extensive damage to crop plants. In contrast to chewing insects, the nature of the plant response to PFIs remains poorly characterized. Scrutiny of the literature concerning transcriptional responses of model and crop plant species to PFIs reveals surprisingly little consensus with respect to the transcripts showing altered abundance following infestation. Nevertheless, core features of the transcriptional response to PFIs can be defined in Arabidopsis thaliana. This comparison of the PFI-associated transcriptional response observed in A. thaliana infested by the generalists Myzus persicae and Bemisia tabaci with the specialist Brevicoryne brassicae highlights the importance of calcium-dependent and receptor kinase-associated signalling. We discuss these findings within the context of the complex cross-talk between the different hormones regulating basal immune response mechanisms in plants. We identify PFI-responsive genes, highlighting the importance of cell wall-associated kinases in plant-PFI interactions, as well as the significant role of kinases containing the domain of unknown function 26. A common feature of plant-PFI interaction is enhanced abundance of transcripts encoding WRKY transcription factors. However, significant divergence was observed with respect to secondary metabolism dependent upon the insect attacker. Transcripts encoding enzymes and proteins associated with glucosinolate metabolism were decreased following attack by the generalist M. persicae but not by the specialist B. brassicae. This analysis provides a comprehensive overview of the molecular patterns associated with the plant response to PFIs and suggests that plants recognize and respond to perturbations in the cell wall occurring during PFI infestation.

  12. Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.

    Science.gov (United States)

    Tumiati, M; Munne, P M; Edgren, H; Eldfors, S; Hemmes, A; Kuznetsov, S G

    2016-09-01

    Almost half of all hereditary breast cancers (BCs) are associated with germ-line mutations in homologous recombination (HR) genes. However, the tumor phenotypes associated with different HR genes vary, making it difficult to define the role of HR in BC predisposition. To distinguish between HR-dependent and -independent features of BCs, we generated a mouse model in which an essential HR gene, Rad51c, is knocked-out specifically in epidermal tissues. Rad51c is one of the key mediators of HR and a well-known BC predisposition gene. Here, we demonstrate that deletion of Rad51c invariably requires inactivation of the Trp53 tumor suppressor (TP53 in humans) to produce mammary carcinomas in 63% of female mice. Nonetheless, loss of Rad51c shortens the latency of Trp53-deficient mouse tumors from 11 to 6 months. Remarkably, the histopathological features of Rad51c-deficient mammary carcinomas, such as expression of hormone receptors and luminal epithelial markers, faithfully recapitulate the histopathology of human RAD51C-mutated BCs. Similar to other BC models, Rad51c/p53 double-mutant mouse mammary tumors also reveal a propensity for genomic instability, but lack the focal amplification of the Met locus or distinct mutational signatures reported for other HR genes. Using the human mammary epithelial cell line MCF10A, we show that deletion of TP53 can rescue RAD51C-deficient cells from radiation-induced cellular senescence, whereas it exacerbates their centrosome amplification and nuclear abnormalities. Altogether, our data indicate that a trend for genomic instability and inactivation of Trp53 are common features of HR-mediated BCs, whereas histopathology and somatic mutation patterns are specific for different HR genes.

  13. Computed tomography of human joints and radioactive waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Ashby, E; Bernardi, R; Hollerbach, K; Logan, C; Martz, H; Roberson, G P

    1999-06-01

    X- and gamma-ray imaging techniques in nondestructive evaluation (NDE) and assay (NDA) have been increasing use in an array of industrial, environmental, military, and medical applications. Much of this growth in recent years is attributed to the rapid development of computed tomography (CT) and the use of NDE throughout the life-cycle of a product. Two diverse examples of CT are discussed. (1) The computational approach to normal joint kinematics and prosthetic joint analysis offers an opportunity to evaluate and improve prosthetic human joint replacements before they are manufactured or surgically implanted. Computed tomography data from scanned joints are segmented, resulting in the identification of bone and other tissues of interest, with emphasis on the articular surfaces. (2) They are developing NDE and NDE techniques to analyze closed waste drums accurately and quantitatively. Active and passive computed tomography (A and PCT) is a comprehensive and accurate gamma-ray NDA method that can identify all detectable radioisotopes present in a container and measure their radioactivity.

  14. Limitation of tritium outgassing from tritiated solid waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Liger, K.; Trabuc, P.; Lefebvre, X.; Troulay, M.; Perrais, C. [CEA, Centre de Cadarache, DEN/DTN/STPA/LIPC, Saint-Paul-lez-Durance (France)

    2015-03-15

    In the framework of the development of fusion thermonuclear reactors, tritiated solid waste is foreseen and will have to be managed. The management of tritiated waste implies limitations in terms of activity and tritium degassing. The degassing tritium can be under the form of tritiated hydrogen, tritiated water and, in some specific cases, negligible amount of tritiated volatile organic compound. Hence, considering the major forms of degassing tritium, CEA has developed a mixed-compound dedicated to tritium trapping in drums. Based on several experiments, the foreseen mixed compound is composed of MnO{sub 2}, Ag{sub 2}O, Pt and molecular sieve, the three first species having the ability to convert tritiated hydrogen into tritiated water and the last one acting as a trap for tritiated water. To assess the performance of the trapping mixture, experimental tests were performed at room temperature on tritiated dust composed of beryllium and carbon. It was shown that the metallic oxides mixture used for tritiated hydrogen conversion is efficient and that tritiated water adsorption was limited due to an inefficient regeneration of the molecular sieve prior to its use. Apart from this point, the tritium release from waste was reduced by a factor of 5.5, which can be improved up to 87 if the adsorption step is efficient.

  15. Marker-assisted molecular profiling and RNA-Seq reveal a disease resistance cluster associated with Uromyces appendiculatus infection in common bean Phaseolus vulgaris L

    Science.gov (United States)

    Common bean (Phaseolus vulgaris L.) is an important legume, useful for its high protein and dietary fiber. The fungal pathogen Uromyces appendiculatus (Pers.) Unger can cause major loss in susceptible varieties of common bean. The Ur-3 locus provides race specific resistance to fungal rust along wit...

  16. Volunteer Conservation Action Data Reveals Large-Scale and Long-Term Negative Population Trends of a Widespread Amphibian, the Common Toad (Bufo bufo)

    Science.gov (United States)

    Petrovan, Silviu O.

    2016-01-01

    Rare and threatened species are the most frequent focus of conservation science and action. With the ongoing shift from single-species conservation towards the preservation of ecosystem services, there is a greater need to understand abundance trends of common species because declines in common species can disproportionately impact ecosystems function. We used volunteer-collected data in two European countries, the United Kingdom (UK) and Switzerland, since the 1970s to assess national and regional trends for one of Europe’s most abundant amphibian species, the common toad (Bufo bufo). Millions of toads were moved by volunteers across roads during this period in an effort to protect them from road traffic. For Switzerland, we additionally estimated trends for the common frog (Rana temporaria), a similarly widespread and common amphibian species. We used state-space models to account for variability in detection and effort and included only populations with at least 5 years of data; 153 populations for the UK and 141 for Switzerland. Common toads declined continuously in each decade in both countries since the 1980s. Given the declines, this common species almost qualifies for International Union for the Conservation of Nature (IUCN) red-listing over this period despite volunteer conservation efforts. Reasons for the declines and wider impacts remain unknown. By contrast, common frog populations were stable or increasing in Switzerland, although there was evidence of declines after 2003. “Toads on Roads” schemes are vital citizen conservation action projects, and the data from such projects can be used for large scale trend estimations of widespread amphibians. We highlight the need for increased research into the status of common amphibian species in addition to conservation efforts focusing on rare and threatened species. PMID:27706154

  17. Nuclear waste calorimeter for very large drums with 385 litres sample volume

    Energy Technology Data Exchange (ETDEWEB)

    Jossens, G.; Mathonat, C. [SETARAM Instrumentation, Caluire (France); Bachelet, F. [CEA Valduc, Is sur Tille (France)

    2015-03-15

    Calorimetry is a very precise and well adapted tool for the classification of drums containing nuclear waste material depending on their level of activities (low, medium, high). A new calorimeter has been developed by SETARAM Instrumentation and the CEA Valduc in France. This new calorimeter is designed for drums having a volume bigger than 100 liters. It guarantees high operator safety by optimizing drum handling and air circulation for cooling, and optimized software for direct measurement of the quantity of nuclear material. The LVC1380 calorimeter makes it possible to work over the range 10 to 3000 mW, which corresponds to approximately 0.03 to 10 g of tritium or 3 to 955 g of {sup 241}Pu in a volume up to 385 liters. This calorimeter is based on the heat flow measurement using Peltier elements which surround the drum in the 3 dimensions and therefore measure all the heat coming from the radioactive stuff whatever its position inside the drum. Calorimeter's insulating layers constitute a thermal barrier designed to filter disturbances until they represent less than 0.001 Celsius degrees and to eliminate long term disturbances associated, for example, with laboratory temperature variations between day and night. A calibration device based on Joule effect has also been designed. Measurement time has been optimized but remains long compared with other methods of measurement such as gamma spectrometry but its main asset is to have a good accuracy for low level activities.

  18. Corrosion of steel drums containing cemented ion-exchange resins as intermediate level nuclear waste

    Energy Technology Data Exchange (ETDEWEB)

    Duffó, G.S. [Departamento de Materiales, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina); Universidad Nacional de San Martín, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina); Consejo Nacional de Investigaciones Científicas y Tecnológicas – CONICET, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina); Farina, S.B., E-mail: farina@cnea.gov.ar [Departamento de Materiales, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina); Universidad Nacional de San Martín, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina); Consejo Nacional de Investigaciones Científicas y Tecnológicas – CONICET, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina); Schulz, F.M. [Consejo Nacional de Investigaciones Científicas y Tecnológicas – CONICET, Av. Gral. Paz 1499, 1650 Buenos Aires (Argentina)

    2013-07-15

    Highlights: • There are no works related to the corrosion of drums containing radioactive waste. • Chloride induces high corrosion rate and after 1 year it drops abruptly. • Decrease in the corrosion rate is due to the lack of water to sustain the process. • Cementated ion-exchange resins do not pose risks of corrosion of the steel drums. -- Abstract: Exhausted ion-exchange resins used in nuclear reactors are immobilized by cementation before being stored. They are contained in steel drums that may undergo internal corrosion depending on the presence of certain contaminants. The objective of this work is to evaluate the corrosion susceptibility of steel drums in contact with cemented ion-exchange resins with different aggressive species. The corrosion potential and the corrosion rate of the steel, and the electrical resistivity of the matrix were monitored for 900 days. Results show that the cementation of ion-exchange resins seems not to pose special risks regarding the corrosion of the steel drums.

  19. Coke drums inspection and evaluation using stress and strain analysis techniques

    Energy Technology Data Exchange (ETDEWEB)

    Haraguchi, Marcio Issamu [Tricom Tecnologia e Servicos de Manutencao Industrial Ltda., Piquete, SP (Brazil); Samman, Mahmod [Houston Engineering Solutions, Houston, TX (United States); Tinoco, Ediberto Bastos; Marangone, Fabio de Castro; Silva, Hezio Rosa da; Barcelos, Gustavo de Carvalho [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    Coke drums deform due to a complex combination of mechanical and thermal cyclic stresses. Bulges have progressive behavior and represent the main maintenance problem related to these drums. Bulge failure typically result in through-wall cracks, leaks, and sometimes fires. Such failures generally do not represent a great risk to personnel. Repairs needed to maintain reliability of these vessels might require extensive interruption to operation which in turn considerably impacts the profitability of the unit. Therefore the condition, progression and severity of these bulges should be closely monitored. Coke drums can be inspected during turnaround with 3D Laser Scanning and Remote Visual Inspection (RVI) tools, resulting in a detailed dimensional and visual evaluation of the internal surface. A typical project has some goals: inspect the equipment to generate maintenance or inspection recommendations, comparison with previous results and baseline data. Until recently, coke drum structural analysis has been traditionally performed analyzing Stress Concentration Factors (SCF) thought Finite Element Analysis methods; however this technique has some serious technical and practical limitations. To avoid these shortcomings, the new strain analysis technique PSI (Plastic Strain Index) was developed. This method which is based on API 579/ ASME FFS standard failure limit represents the state of the art of coke drum bulging severity assessment has an excellent correlation with failure history. (author)

  20. Novel Fabrication Techniques for Wafer-Scale Graphene Drum NanoElectroMechanical Resonators

    Science.gov (United States)

    Lee, Sunwoo; Chen, Changyao; Deshpande, Vikram V.; Lee, Gwan Hyoung; Storch, Isaac; Zhang, Congchun; Yu, Young-Jun; Kim, Philip; McEuen, Paul; Hone, James

    2012-02-01

    Graphene NanoElectroMechanical Systems (NEMS) have shown excellent mass sensitivity as well as resonant and oscillatory behaviors that are desirable in mass sensors and active elements in Radio Frequency Integrated Circuit (RFIC) design. Out of many structures proposed for graphene NEMS, it has been recently shown that a drum resonator exhibits higher Q-factor than other structures such as a bar resonator. However, fabricating a large array of drum graphene resonator has been problematic because liquid or gas can be trapped inside the drum. Such issues led to designs with a hole in the center of a drum or with a drainage trench, either at the cost of additional lithography step or lowered Q-factor. Here, we demonstrate two novel fabrication methods that are free of the trapping without any compromise in additional lithography step or Q-factor degradation. In one method, wafer scale graphene is dry-stamped on prefabricated leads, holes and local gates. In the other method, an resist strip with a circular hole at the center holds graphene underneath. I will discuss direct electrical readout and characterization of devices using these two methods. These drum structures may provide a practical way to achieve wafer scale high Q graphene NEMS.

  1. Tool-assisted rhythmic drumming in palm cockatoos shares key elements of human instrumental music.

    Science.gov (United States)

    Heinsohn, Robert; Zdenek, Christina N; Cunningham, Ross B; Endler, John A; Langmore, Naomi E

    2017-06-01

    All human societies have music with a rhythmic "beat," typically produced with percussive instruments such as drums. The set of capacities that allows humans to produce and perceive music appears to be deeply rooted in human biology, but an understanding of its evolutionary origins requires cross-taxa comparisons. We show that drumming by palm cockatoos (Probosciger aterrimus) shares the key rudiments of human instrumental music, including manufacture of a sound tool, performance in a consistent context, regular beat production, repeated components, and individual styles. Over 131 drumming sequences produced by 18 males, the beats occurred at nonrandom, regular intervals, yet individual males differed significantly in the shape parameters describing the distribution of their beat patterns, indicating individual drumming styles. Autocorrelation analyses of the longest drumming sequences further showed that they were highly regular and predictable like human music. These discoveries provide a rare comparative perspective on the evolution of rhythmicity and instrumental music in our own species, and show that a preference for a regular beat can have other origins before being co-opted into group-based music and dance.

  2. Traditional Saami hunting in relation to drum motifs of animals and hunting

    Directory of Open Access Journals (Sweden)

    Rolf Kjellström

    1991-01-01

    Full Text Available The focus of this paper is on the traditional Saami hunting in relation to the animal and hunting motifs on their drum, more specifially the southern Saami drums. One may wonder if it is possible for anyone to interpret a picture unconditionally. One has a certain ground of one's own to stand on and the question arises of whether this is the correct position, when -as in the present case — we approach another culture. We naturally include the experiences of our own culture in interpretations of another culture. The animal which is the commonest species on the southern Saami drums, is the reindeer. Other animals that occur are elks, wolves, beavers, foxes, snakes, among others. Considering the Saamis' hunting weapons, the most important of these were the bow and arrow, and the spear or spear shaft. Of these weapons it is the bow which is most often portrayed on drums. Also some trapping implement like a gin may appear on a drum, but in general we have little or no information about hunting or trapping methods at all.

  3. Hazards Associated with Legacy Nitrate Salt Waste Drums Managed under the Container Isolation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Funk, David John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Clark, David Lewis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-01-07

    At present, there are 29 drums of nitrate waste salts (oxidizers with potentially acidic liquid bearing RCRA characteristics D001 and D002) that are awaiting processing, specifically to eliminate these characteristics and to allow for ultimate disposition at WIPP. As a result of the Feb. 14th, 2014 drum breach at WIPP, and the subsequent identification of the breached drum as a product ofLANL TRU waste disposition on May 15th, 2014, these 29 containers were moved into the Perrnacon in Dome 231 at TA-54 Area G, as part of the New Mexico Environment Department (NMED) approved container isolation plan. The plan is designed to mitigate hazards associated with the nitrate salt bearing waste stream. The purpose of this document is to articulate the hazards associated with un-remediated nitrate salts while in storage at LANL. These hazards are distinctly different from the Swheat-remediated nitrate salt bearing drums, and this document is intended to support the request to remove the un-remediated drums from management under the container isolation plan. Plans to remediate and/or treat both of these waste types are being developed separately, and are beyond the scope of this document.

  4. A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness

    OpenAIRE

    Cheishvili, David; Stefanska, Barbara; Yi, Cao; Li, Chen Chen; Yu, Patricia; Arakelian, Ani; Tanvir, Imrana; Khan, Haseeb Ahmed; Rabbani, Shafaat; Szyf, Moshe

    2015-01-01

    Cancer invasion and metastasis is the most morbid aspect of cancer and is governed by different cellular mechanisms than those driving the deregulated growth of tumors. We addressed here the question of whether a common DNA methylation signature of invasion exists in cancer cells from different origins that differentiates invasive from non-invasive cells. We identified a common DNA methylation signature consisting of hyper- and hypomethylation and determined the overlap of differences in DNA ...

  5. Drum rotor blowers in EC technology. Energy conservation, comfortable control, low noise; Trommellaeufer-Ventilatoren in EC-Technik. Energieersparnis, komfortable Regelung und geringe Geraeuschentwicklung

    Energy Technology Data Exchange (ETDEWEB)

    Sigloch, U. [ebm-papst Mulfingen GmbH und Co. KG (Germany). Projektmanagement Vertrieb Europa; Reiff, E.C. [Redaktionsbuero Stutensee (Germany)

    2008-07-01

    Compact drum rotor blowers with forward-curved blades are quite common in air conditioning and ventilation because of their high efficiency and compact dimensions. They are found in air conditioner boxes, in air current systems in department stores, or in fan coils in hotel rooms, wherever other types of blowers would be too big. Until recently, EC technology was not available for the blower motors so the users had do accept low efficiency and the poor control options of conventional AC drives. This has changed by now. (orig.)

  6. A Simple Approach to Determine Noise Frequency of Boiler Drum Level

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper proposed a simple approach to determine noise frequency of boiler drum level in order to improve control performance. Based on analysis of uncertainty of drum level, the redundant oscillation component of signal, noise is ascribed to the surface wave of drum water. According to the characteristic of surface wave, a new method was proposed to determine noise's frequency band. By gradually removing the lowest frequency component of signal, the variance of remained component is calculated and observed. An apparent turning point was found and the corresponding critical frequcncy was determined. With this result a low-pass filter was designed to separate noise component. Finally validation is conducted by comparing the proposed method and conventional ones. Results show the accuracy and simpleness of the proposed method.

  7. TRANSITION PHENOMENON INVESTIGATION BETWEEN DIFFERENT FLOW REGIMES IN A ROTARY DRUM

    Directory of Open Access Journals (Sweden)

    D. A. Santos

    Full Text Available Abstract Rotary drums can show different granular flow regimes each one with its own specific flow behavior, which increase the complexity in their study. The way particles move inside the rotary drum is directly related to the mass and energy transfer rates, and consequently to the process performance. Thus, an experimental investigation regarding the transition between different flow regimes inside a rotary drum was carried out in the present work. To the best of our knowledge, the hysteresis phenomenon was observed for the first time in the transition between cataracting-centrifuging regimes, which was shown to be dependent on the physical properties of the particles such as sphericity, density and particle-wall friction coefficient. A new expression for the centrifuging critical rotation speed was proposed in this work.

  8. Drumming as a Medium to Promote Emotional and Social Functioning of Children in Middle Childhood in Residential Care

    Science.gov (United States)

    Flores, Kim; van Niekerk, Caroline; le Roux, Liana

    2016-01-01

    This study explores the potential of drumming to enhance emotional and social functioning of children in residential care. Fifteen children (aged 7-12) from a child and youth care centre in South Africa attended four months of weekly drumming sessions. Gestalt theory principles informed the workshops' theoretical foundation and interpretation of…

  9. 40 CFR 264.316 - Disposal of small containers of hazardous waste in overpacked drums (lab packs).

    Science.gov (United States)

    2010-07-01

    ... HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Landfills § 264.316 Disposal of small containers of hazardous waste in overpacked drums (lab packs). Small containers of hazardous waste in overpacked... hazardous waste in overpacked drums (lab packs). 264.316 Section 264.316 Protection of Environment...

  10. Control law design for the fuel consumption system of steam drum boiler taking into consideration the economy of energy resources

    Directory of Open Access Journals (Sweden)

    Juravliov A.A.

    2005-12-01

    Full Text Available The cascade system for maintaining the level in the steam boiler drum was investigated. Main features of the system are it’s variable structure which changes depending on the load variation relative to its previous value, and the use of the model of the drum level in dependence of the feedwater flow rate.

  11. Feeling the beat where it counts: fostering multi-limb rhythm skills with the haptic drum kit

    NARCIS (Netherlands)

    Holland, S.; Bouwer, A.J.; Dalgleish, M.; Hurtig, T.M.

    2010-01-01

    This paper introduces a tool known as the Haptic Drum Kit, which employs four computer-controlled vibrotactile devices, one attached to each wrist and ankle. In the applications discussed here, haptic pulses are used to guide the playing, on a drum kit, of rhythmic patterns that require multi-limb

  12. An ABC of Drumming: Children's Narratives about Beat, Rhythm and Groove in a Primary Classroom

    Science.gov (United States)

    Mackinlay, Elizabeth

    2014-01-01

    In this paper, I use a bricolage of arts-based research and writing practices to explore narratives by Grade 4 children about their experiences in a drumming circle called "Bam Bam" as represented in a text they created with me called An ABC of drumming. The term "narrative" is used here in a contemporary sense to…

  13. Genome evolution trend of common carp (Cyprinus carpio L.) as revealed by the analysis of microsatellite loci in a gynogentic family

    Institute of Scientific and Technical Information of China (English)

    Yan Zhang; Liqun Liang; Peng Jiang; Dayu Li; Cuiyun Lu; Xiaowen Sun

    2008-01-01

    Genome evolution arises from two main ways of duplication and reduction. Fish specific genome duplication (FSGD) may have oc curred before the radiation of the teleosts. Common carp {Cyprinus carpio L.) has been considered to be a tetraploid species, because of its chromosome numbers (2n=100) and its high DNA content. Using 69 microsatellite primer pairs, the variations were studied to better understand the genome evolution (genome duplication and diploidization) of common carp from a gynogenetic family. About 48% of primer pairs were estimated to amplify duplicates based on the number of PCR amplification per individual. Segregation patterns in the family suggested a partially duplicated genome structure and disomic inheritance. This indicates that the common carp is tetraploid and polyploidy occurred by allotetraploidy. Two primer pairs (HLJ021 and HLJ332) were estimated to amplify reduction based on the number of PCR amplification per individual. One allele in HLJ002 locus and HLJ332 locus was clearly lost in the gynogenetic family and the same as in six wild populations. Segregation patterns in the family suggested a partially diplodization genome structure. A hypothesis transition (dynamic) and equilibrium (static) were proposed to explain the common carp genome evolution between genome duplication and diploidization.

  14. An eye tracking system for monitoring face scanning patterns reveals the enhancing effect of oxytocin on eye contact in common marmosets.

    Science.gov (United States)

    Kotani, Manato; Shimono, Kohei; Yoneyama, Toshihiro; Nakako, Tomokazu; Matsumoto, Kenji; Ogi, Yuji; Konoike, Naho; Nakamura, Katsuki; Ikeda, Kazuhito

    2017-09-01

    Eye tracking systems are used to investigate eyes position and gaze patterns presumed as eye contact in humans. Eye contact is a useful biomarker of social communication and known to be deficient in patients with autism spectrum disorders (ASDs). Interestingly, the same eye tracking systems have been used to directly compare face scanning patterns in some non-human primates to those in human. Thus, eye tracking is expected to be a useful translational technique for investigating not only social attention and visual interest, but also the effects of psychiatric drugs, such as oxytocin, a neuropeptide that regulates social behavior. In this study, we report on a newly established method for eye tracking in common marmosets as unique New World primates that, like humans, use eye contact as a mean of communication. Our investigation was aimed at characterizing these primates face scanning patterns and evaluating the effects of oxytocin on their eye contact behavior. We found that normal common marmosets spend more time viewing the eyes region in common marmoset's picture than the mouth region or a scrambled picture. In oxytocin experiment, the change in eyes/face ratio was significantly greater in the oxytocin group than in the vehicle group. Moreover, oxytocin-induced increase in the change in eyes/face ratio was completely blocked by the oxytocin receptor antagonist L-368,899. These results indicate that eye tracking in common marmosets may be useful for evaluating drug candidates targeting psychiatric conditions, especially ASDs. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials.

    Directory of Open Access Journals (Sweden)

    Lycias Zembe

    Full Text Available The genetic diversity of HIV-1 across the globe is a major challenge for developing an HIV vaccine. To facilitate immunogen design, it is important to characterize clusters of commonly targeted T-cell epitopes across different HIV clades. To address this, we examined 39 HIV-1 clade C infected individuals for IFN-γ Gag-specific T-cell responses using five sets of overlapping peptides, two sets matching clade C vaccine candidates derived from strains from South Africa and China, and three peptide sets corresponding to consensus clades A, B, and D sequences. The magnitude and breadth of T-cell responses against the two clade C peptide sets did not differ, however clade C peptides were preferentially recognized compared to the other peptide sets. A total of 84 peptides were recognized, of which 19 were exclusively from clade C, 8 exclusively from clade B, one peptide each from A and D and 17 were commonly recognized by clade A, B, C and D. The entropy of the exclusively recognized peptides was significantly higher than that of commonly recognized peptides (p = 0.0128 and the median peptide processing scores were significantly higher for the peptide variants recognized versus those not recognized (p = 0.0001. Consistent with these results, the predicted Major Histocompatibility Complex Class I IC(50 values were significantly lower for the recognized peptide variants compared to those not recognized in the ELISPOT assay (p<0.0001, suggesting that peptide variation between clades, resulting in lack of cross-clade recognition, has been shaped by host immune selection pressure. Overall, our study shows that clade C infected individuals recognize clade C peptides with greater frequency and higher magnitude than other clades, and that a selection of highly conserved epitope regions within Gag are commonly recognized and give rise to cross-clade reactivities.

  16. Comparative Proteomic, Physiological, Morphological, and Biochemical Analyses Reveal the Characteristics of the Diploid Spermatozoa of Allotetraploid Hybrids of Red Crucian Carp (Carassius auratus) and Common Carp (Cyprinus carpio).

    Science.gov (United States)

    Duan, Wei; Xu, Kang; Hu, Fangzhou; Zhang, Yi; Wen, Ming; Wang, Jing; Tao, Min; Luo, Kaikun; Zhao, Rurong; Qin, Qinbo; Zhang, Chun; Liu, Jinhui; Liu, Yun; Liu, Shaojun

    2016-02-01

    The generation of diploid spermatozoa is essential for the continuity of tetraploid lineages. The DNA content of diploid spermatozoa from allotetraploid hybrids of red crucian carp and common carp was nearly twice as great as that of haploid spermatozoa from common carp, and the durations of rapid and slow progressive motility were longer. We performed comparative proteomic analyses to measure variations in protein composition between diploid and haploid spermatozoa. Using two-dimensional electrophoresis followed by liquid chromatography tandem mass spectrometry, 21 protein spots that changed in abundance were analyzed. As the common carp and the allotetraploid hybrids are not fully sequenced organisms, we identified proteins by Mascot searching against the National Center for Biotechnology Information non-redundant (NR) protein database for the zebrafish (Danio rerio), and verified them against predicted homologous proteins derived from transcriptomes of the testis. Twenty protein spots were identified successfully, belonging to four gene ontogeny categories: cytoskeleton, energy metabolism, the ubiquitin-proteasome system, and other functions, indicating that these might be associated with the variation in diploid spermatozoa. This categorization of variations in protein composition in diploid spermatozoa will provide new perspectives on male polyploidy. Moreover, our approach indicates that transcriptome data are useful for proteomic analyses in organisms lacking full protein sequences.

  17. Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development

    OpenAIRE

    Beauchemin, Kyle J.; Julie M. Wells; Kho, Alvin T.; Philip, Vivek M.; Kamir, Daniela; Kohane, Isaac S; Graber, Joel H.; Bult, Carol J.

    2016-01-01

    To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using Principal Component Analysis and least squares regression modeling, we identified both strain-independent and strain-dependent patterns of gene expression. The 4,683 genes contributing to the strain-independent expression patterns w...

  18. High resolution microfluidic single cell transcriptional profiling reveals clinically relevant subtypes among human stem cell populations commonly utilized in cell-based therapies

    Directory of Open Access Journals (Sweden)

    Robert C. Rennert

    2016-03-01

    Full Text Available Stem cell therapies can promote neural repair and regeneration, yet controversy regarding optimal cell source and mechanism of action has slowed clinical translation, potentially due to undefined cellular heterogeneity. Single cell resolution is needed to identify clinically relevant subpopulations with the highest therapeutic relevance. We combine single cell microfluidic analysis with advanced computational modeling to study for the first time two common sources for cell-based therapies, human NSCs and MSCs. This methodology has the potential to logically inform cell source decisions for any clinical application.

  19. Comparison of local features from two Spanish hospitals reveals common and specific traits at multiple levels of the molecular epidemiology of metallo-β-lactamase-producing Pseudomonas spp.

    Science.gov (United States)

    Viedma, Esther; Estepa, Vanesa; Juan, Carlos; Castillo-Vera, Jane; Rojo-Bezares, Beatriz; Seral, Cristina; Castillo, Francisco Javier; Sáenz, Yolanda; Torres, Carmen; Chaves, Fernando; Oliver, Antonio

    2014-01-01

    Twenty-seven well-characterized metallo-β-lactamase (MBL)-producing Pseudomonas strains from two distantly located hospitals were analyzed. The results revealed specific features defining the multilevel epidemiology of strains from each hospital in terms of species, clonality, predominance of high-risk clones, composition/diversity of integrons, and linkages of Tn402-related structures. Therefore, despite the global trends driving the epidemiology of MBL-producing Pseudomonas spp., the presence of local features has to be considered in order to understand this threat and implement proper control strategies.

  20. Common-garden experiments reveal geographical variation in the interaction among Crotalaria pallida (Leguminosae: Papilionideae), Utetheisa ornatrix L. (Lepidoptera: Arctiidae), and extrafloral nectary visiting ants.

    Science.gov (United States)

    Franco, M S; Cogni, R

    2013-06-01

    The study of geographical variation is a key approach to understand evolution of ecological interactions. We investigated geographical variation in the interaction among Crotalaria pallida (Leguminosae: Papilionideae), its specialized herbivore, Utetheisa ornatrix L. (Lepidoptera: Arctiidae), and ants attracted to extrafloral nectaries (EFNs). First, we used common-garden experiments with plants collected in different sites at different geographical scales to test for differences among populations in C. pallida attractiveness to ants. When we compared three populations from Southeast Brazil (150 km apart), the number of visiting ants per plant, and the percent of termite baits attacked by ants, were significantly different among plant populations. In a comparison of populations from SE Brazil and Florida (USA), there was no significant difference between the populations in the number of ants per plant or the frequency of baits attacked. Second, we tested in a common garden if U. ornatrix larvae present any behavior to avoid ant predation, and if there were genetic differences among populations. We observed that most larvae moved away from the vicinity of the EFNs (flowers and fruits) to the plant leaves. Of the larvae that moved to leaves, only 10% were attacked by ants while 89% of larvae that stayed near the fruit/flower were attacked. There was a significant difference among populations in the frequency of larvae that moved to the leaves and the frequency of larvae attacked by ants. We discuss the possible causes of the geographical differences observed and propose future research directions in this system.

  1. A Click Chemistry‐Based Proteomic Approach Reveals that 1,2,4‐Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile

    Science.gov (United States)

    Ismail, Hanafy M.; Barton, Victoria E.; Panchana, Matthew; Charoensutthivarakul, Sitthivut; Biagini, Giancarlo A.; Ward, Stephen A.

    2016-01-01

    Abstract In spite of the recent increase in endoperoxide antimalarials under development, it remains unclear if all these chemotypes share a common mechanism of action. This is important since it will influence cross‐resistance risks between the different classes. Here we investigate this proposition using novel clickable 1,2,4‐trioxolane activity based protein‐profiling probes (ABPPs). ABPPs with potent antimalarial activity were able to alkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7). Importantly, comparison of the alkylation fingerprint with that generated from an artemisinin ABPP equivalent confirms a highly conserved alkylation profile, with both endoperoxide classes targeting proteins in the glycolytic, hemoglobin degradation, antioxidant defence, protein synthesis and protein stress pathways, essential biological processes for plasmodial survival. The alkylation signatures of the two chemotypes show significant overlap (ca. 90 %) both qualitatively and semi‐quantitatively, suggesting a common mechanism of action that raises concerns about potential cross‐resistance liabilities. PMID:27397940

  2. Swing once more: Relating timing and tempo in expert jazz drumming

    NARCIS (Netherlands)

    Honing, H.; de Haas, W.B.

    2008-01-01

    Swing refers to a characteristic long-short subdivision of the beat that is generally considered a crucial aspect that contributes to the quality of a jazz or pop performance. The current study measures this pattern (referred to as the 'swing ratio') at different tempi in jazz drumming. The experime

  3. Swing Once More: Relating Timing and Tempo in Expert Jazz Drumming

    NARCIS (Netherlands)

    Honing, H.; de Haas, W.B.

    2008-01-01

    Swing refers to a characteristic long-short subdivision of the beat that is generally considered a crucial aspect that contributes to the quality of a jazz or pop performance. The current study measures this pattern (referred to as the ‘swing ratio’) at different tempi in jazz drumming. The experime

  4. Synchronized Drumming Enhances Activity in the Caudate and Facilitates Prosocial Commitment - If the Rhythm Comes Easily

    NARCIS (Netherlands)

    Kokal, Idil; Engel, Annerose; Kirschner, Sebastian; Keysers, Christian

    2011-01-01

    Why does chanting, drumming or dancing together make people feel united? Here we investigate the neural mechanisms underlying interpersonal synchrony and its subsequent effects on prosocial behavior among synchronized individuals. We hypothesized that areas of the brain associated with the processin

  5. Heat and water transfer in a rotating drum containing solid substrate particles

    NARCIS (Netherlands)

    Schutyser, M.A.I.; Schutyser, M.A.I.; Weber, F.J.; Briels, Willem J.; Rinzema, A.; Boom, R.M.

    2003-01-01

    In previous work we reported on the simulation of mixing behavior of a slowly rotating drum for solid-state fermentation (SSF) using a discrete particle model. In this investigation the discrete particle model is extended with heat and moisture transfer. Heat transfer is implemented in the model via

  6. Drums and Poems: An Intervention Promoting Empathic Connection and Literacy in Children

    Science.gov (United States)

    Sassen, Georgia

    2012-01-01

    Expressive therapies can be used with groups of children to increase empathy and reduce bullying and violence. When educators feel pressured to focus on standardized tests and basic skills, there is little attention and time for such programs. Drums and Poems is an intervention that counselors and teachers can use to address these problems by…

  7. The Extraordinary Nature of Barney's Drumming: A Complementary Study of Ordinary Noise Making in Chimpanzees.

    Science.gov (United States)

    Dufour, Valérie; Pasquaretta, Cristian; Gayet, Pierre; Sterck, Elisabeth H M

    2017-01-01

    In a previous study (Dufour et al., 2015) we reported the unusual characteristics of the drumming performance of a chimpanzee named Barney. His sound production, several sequences of repeated drumming on an up-turned plastic barrel, shared features typical for human musical drumming: it was rhythmical, decontextualized, and well controlled by the chimpanzee. This type of performance raises questions about the origins of our musicality. Here we recorded spontaneously occurring events of sound production with objects in Barney's colony. First we collected data on the duration of sound making. Here we examined whether (i) the context in which objects were used for sound production, (ii) the sex of the producer, (iii) the medium, and (iv) the technique used for sound production had any effect on the duration of sound making. Interestingly, duration of drumming differed across contexts, sex, and techniques. Then we filmed as many events as possible to increase our chances of recording sequences that would be musically similar to Barney's performance in the original study. We filmed several long productions that were rhythmically interesting. However, none fully met the criteria of musical sound production, as previously reported for Barney.

  8. Development on New Style of Drummed Nuclear Waste Neutron Counting System

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Designing a new style of drummed nuclear waste neutron counting system (WNC) was carried out in 2011. 3He proportional tubes are used as detector in this system. According to the limited quantity of 3He tubes, Monte Carlo method is used for

  9. The Extraordinary Nature of Barney's Drumming: A Complementary Study of Ordinary Noise Making in Chimpanzees

    Science.gov (United States)

    Dufour, Valérie; Pasquaretta, Cristian; Gayet, Pierre; Sterck, Elisabeth H. M.

    2017-01-01

    In a previous study (Dufour et al., 2015) we reported the unusual characteristics of the drumming performance of a chimpanzee named Barney. His sound production, several sequences of repeated drumming on an up-turned plastic barrel, shared features typical for human musical drumming: it was rhythmical, decontextualized, and well controlled by the chimpanzee. This type of performance raises questions about the origins of our musicality. Here we recorded spontaneously occurring events of sound production with objects in Barney's colony. First we collected data on the duration of sound making. Here we examined whether (i) the context in which objects were used for sound production, (ii) the sex of the producer, (iii) the medium, and (iv) the technique used for sound production had any effect on the duration of sound making. Interestingly, duration of drumming differed across contexts, sex, and techniques. Then we filmed as many events as possible to increase our chances of recording sequences that would be musically similar to Barney's performance in the original study. We filmed several long productions that were rhythmically interesting. However, none fully met the criteria of musical sound production, as previously reported for Barney. PMID:28154521

  10. Technical information for the relocation and treatment of Argonne National Laboratory drums

    Energy Technology Data Exchange (ETDEWEB)

    Clinton, R.

    1997-08-07

    The technical information in this document is to evaluate waste drums stored in Solid Waste Project Management facilities that contain organic and potentially flammable gases. The document provides an evaluation of the planned venting of potentially flammable gases and the potential risks associated with the task.

  11. Performance of helical cutting drum with additional picks on the face side

    Energy Technology Data Exchange (ETDEWEB)

    Krauze, K.; Paraszczak, J. (University of Mining Metallurgy, Krakow (Poland))

    1990-01-01

    Extensive study has shown that it is necessary to apply additional picks to a shearer in order to eliminate or diminish the forces pushing it out of the coal face. The presented design of the cutting drum with three or four additional picks has met these conditions, and tests and observations have confirmed the value of this design. 4 figs., 1 tab.

  12. A Drum's Trans-Atlantic Journey from Africa to the Americas and ...

    African Journals Online (AJOL)

    2010-12-08

    Long .... by the use of the drum were in Pidgin English, sung by workers of multiethnic origin ...... Universidad Nacional de Educación a Distancia, 1999. ... cuba. colección de Artículos. .... Investigaciones Científicas (CSIC), Madrid.

  13. Field test results for radioactive waste drum characterization with Waste Inspection Tomography (WIT)

    Energy Technology Data Exchange (ETDEWEB)

    Bernardi, R.T. [Bio-Imaging Research, Inc., Lincolnshire, IL (United States)

    1997-11-01

    This paper summarizes the design, fabrication, factory testing, evaluation and demonstration of waste inspection tomography (WIT). WIT consists of a self-sufficient, mobile semi-trailer for Non-Destructive Evaluation and Non-Destructive Assay (NDE/NDA) characterization of nuclear waste drums using X-ray and gamma-ray tomographic techniques. The 23-month WIT Phase I initial test results include 2 MeV Digital Radiography (DR), Computed Tomography (CT), Anger camera imaging, Single Photon Emission Computed Tomography (SPECT), Gamma-Ray Spectroscopy, Collimated Gamma Scanning (CGS), and Active and Passive Computed Tomography (A&PCT) using a 1.4 mCi source of {sup 166}Ho. These techniques were initially demonstrated on a 55-gallon phantom drum with three simulated waste matrices of combustibles, heterogeneous metals, and cement using check sources of gamma active isotopes. Waste matrix identification, isotopic identification, and attenuation-corrected gamma activity determination were all demonstrated nondestructively and noninvasively. Preliminary field tests results with nuclear waste drums are summarized. WIT has inspected drums with 0 to 20 grams plutonium 239. The minimum measured was 0.131 gram plutonium 239 in cement. 8 figs.

  14. Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

    Science.gov (United States)

    Le Tallec, Benoît; Millot, Gaël Armel; Blin, Marion Esther; Brison, Olivier; Dutrillaux, Bernard; Debatisse, Michelle

    2013-08-15

    Cancer genomes exhibit numerous deletions, some of which inactivate tumor suppressor genes and/or correspond to unstable genomic regions, notably common fragile sites (CFSs). However, 70%-80% of recurrent deletions cataloged in tumors remain unexplained. Recent findings that CFS setting is cell-type dependent prompted us to reevaluate the contribution of CFS to cancer deletions. By combining extensive CFS molecular mapping and a comprehensive analysis of CFS features, we show that the pool of CFSs for all human cell types consists of chromosome regions with genes over 300 kb long, and different subsets of these loci are committed to fragility in different cell types. Interestingly, we find that transcription of large genes does not dictate CFS fragility. We further demonstrate that, like CFSs, cancer deletions are significantly enriched in genes over 300 kb long. We now provide evidence that over 50% of recurrent cancer deletions originate from CFSs associated with large genes.

  15. ANALYSIS OF AVAILABLE HYDROGEN DATA & ACCUMULATION OF HYDROGEN IN UNVENTED TRANSURANIC (TRU) DRUMS

    Energy Technology Data Exchange (ETDEWEB)

    DAYLEY, L

    2004-06-24

    This document provides a response to the second action required in the approval for the Justification for Continued Operations (JCO) Assay and Shipment of Transuranic (TRU) Waste Containers in 218-W-4C. The Waste Management Project continues to make progress toward shipping certified TRU waste to the Waste Isolation Pilot Plant (WIPP). As the existing inventory of TRU waste in the Central Waste Complex (CWC) storage buildings is shipped, and the uncovered inventory is removed from the trenches and prepared for shipment from the Hanford Site, the covered inventory of suspect TRU wastes must be retrieved and prepared for processing for shipment to WIPP. Accumulation of hydrogen in unvented TRU waste containers is a concern due to the possibility of explosive mixtures of hydrogen and oxygen. The frequency and consequence of these gas mixtures resulting in an explosion must be addressed. The purpose of this study is to recommend an approach and schedule for venting TRU waste containers in the low-level burial ground (LLBG) trenches in conjunction with TRU Retrieval Project activities. This study provides a detailed analysis of the expected probability of hydrogen gas accumulation in significant quantities in unvented drums. Hydrogen gas accumulation in TRU drums is presented and evaluated in the following three categories: Hydrogen concentrations less than 5 vol%; Hydrogen between 5-15 vol%; and Hydrogen concentrations above 15 vol%. This analysis is based on complex-wide experience with TRU waste drums, available experimental data, and evaluations of storage conditions. Data reviewed in this report includes experience from the Idaho National Environmental Engineering Laboratories (INEEL), Savannah River Site (SRS), Los Alamos National Laboratories (LANL), Oak Ridge National Laboratories, (ORNL), Rocky Flats sites, Matrix Depletion Program and the National Transportation and Packaging Program. Based on this analysis, as well as an assessment of the probability and

  16. The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles But Also Signatures of Common Ancestry

    Energy Technology Data Exchange (ETDEWEB)

    de Wit, Pierre J. G. M.; van der Burgt, Ate; Okmen, Bilal; Stergiopoulos, Ioannis; Abd-Elsalam, Kamel A.; Aerts, Andrea L.; Bahkali, Ali H.; Beenen, Henriek G.; Chettri, Oranav; Cos, Murray P.; Datema, Erwin; de Vries, Ronald P.; DHillon, Braham; Ganley, Austen R.; Griffiths, Scott A.; Guo, Yanan; Gamelin, Richard C.; Henrissat, Bernard; Kabir, M. Shahjahan; Jashni, Mansoor Karimi; Kema, Gert; Klaubauf, Sylvia; Lapidus, Alla; Levasseur, Anthony; Lindquist, Erika; Mehrabi, Rahim; Ohm, Robin A.; Owen, Timothy J.; Salamov, Asaf; Schwelm, Arne; Schijlen, Elio; Sun, Hui; van den Burg, Harrold A.; van Burg, Roeland C. H. J.; Zhang, Shuguang; Goodwin, Stephen B.; Grigoriev, Igor V.; Collemare, Jerome; Bradshaw, Rosie E.

    2012-05-04

    We sequenced and compared the genomes of the Dothideomycete fungal plant pathogens Cladosporium fulvum (Cfu) (syn. Passalora fulva) and Dothistroma septosporum (Dse) that are closely related phylogenetically, but have different lifestyles and hosts. Although both fungi grow extracellularly in close contact with host mesophyll cells, Cfu is a biotroph infecting tomato, while Dse is a hemibiotroph infecting pine. The genomes of these fungi have a similar set of genes (70percent of gene content in both genomes are homologs), but differ significantly in size (Cfu >61.1-Mb; Dse 31.2-Mb), which is mainly due to the difference in repeat content (47.2percent in Cfu versus 3.2percent in Dse). Recent adaptation to different lifestyles and hosts is suggested by diverged sets of genes. Cfu contains an tomatinase gene that we predict might be required for detoxification of tomatine, while this gene is absent in Dse. Many genes encoding secreted proteins are unique to each species and the repeat-rich areas in Cfu are enriched for these species-specific genes. In contrast, conserved genes suggest common host ancestry. Homologs of Cfu effector genes, including Ecp2 and Avr4, are present in Dse and induce a Cf-Ecp2- and Cf-4-mediated hypersensitive response, respectively. Strikingly, genes involved in production of the toxin dothistromin, a likely virulence factor for Dse, are conserved in Cfu, but their expression differs markedly with essentially no expression by Cfu in planta. Likewise, Cfu has a carbohydrate-degrading enzyme catalog that is more similar to that of necrotrophs or hemibiotrophs and a larger pectinolytic gene arsenal than Dse, but many of these genes are not expressed in planta or are pseudogenized. Overall, comparison of their genomes suggests that these closely related plant pathogens had a common ancestral host but since adapted to different hosts and lifestyles by a combination of differentiated gene content, pseudogenization, and gene regulation.

  17. The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.

    Science.gov (United States)

    de Wit, Pierre J G M; van der Burgt, Ate; Ökmen, Bilal; Stergiopoulos, Ioannis; Abd-Elsalam, Kamel A; Aerts, Andrea L; Bahkali, Ali H; Beenen, Henriek G; Chettri, Pranav; Cox, Murray P; Datema, Erwin; de Vries, Ronald P; Dhillon, Braham; Ganley, Austen R; Griffiths, Scott A; Guo, Yanan; Hamelin, Richard C; Henrissat, Bernard; Kabir, M Shahjahan; Jashni, Mansoor Karimi; Kema, Gert; Klaubauf, Sylvia; Lapidus, Alla; Levasseur, Anthony; Lindquist, Erika; Mehrabi, Rahim; Ohm, Robin A; Owen, Timothy J; Salamov, Asaf; Schwelm, Arne; Schijlen, Elio; Sun, Hui; van den Burg, Harrold A; van Ham, Roeland C H J; Zhang, Shuguang; Goodwin, Stephen B; Grigoriev, Igor V; Collemare, Jérôme; Bradshaw, Rosie E

    2012-01-01

    We sequenced and compared the genomes of the Dothideomycete fungal plant pathogens Cladosporium fulvum (Cfu) (syn. Passalora fulva) and Dothistroma septosporum (Dse) that are closely related phylogenetically, but have different lifestyles and hosts. Although both fungi grow extracellularly in close contact with host mesophyll cells, Cfu is a biotroph infecting tomato, while Dse is a hemibiotroph infecting pine. The genomes of these fungi have a similar set of genes (70% of gene content in both genomes are homologs), but differ significantly in size (Cfu >61.1-Mb; Dse 31.2-Mb), which is mainly due to the difference in repeat content (47.2% in Cfu versus 3.2% in Dse). Recent adaptation to different lifestyles and hosts is suggested by diverged sets of genes. Cfu contains an α-tomatinase gene that we predict might be required for detoxification of tomatine, while this gene is absent in Dse. Many genes encoding secreted proteins are unique to each species and the repeat-rich areas in Cfu are enriched for these species-specific genes. In contrast, conserved genes suggest common host ancestry. Homologs of Cfu effector genes, including Ecp2 and Avr4, are present in Dse and induce a Cf-Ecp2- and Cf-4-mediated hypersensitive response, respectively. Strikingly, genes involved in production of the toxin dothistromin, a likely virulence factor for Dse, are conserved in Cfu, but their expression differs markedly with essentially no expression by Cfu in planta. Likewise, Cfu has a carbohydrate-degrading enzyme catalog that is more similar to that of necrotrophs or hemibiotrophs and a larger pectinolytic gene arsenal than Dse, but many of these genes are not expressed in planta or are pseudogenized. Overall, comparison of their genomes suggests that these closely related plant pathogens had a common ancestral host but since adapted to different hosts and lifestyles by a combination of differentiated gene content, pseudogenization, and gene regulation.

  18. The Energy Spectrum of Telescope Array's Middle Drum Detector and the Direct Comparison to the High Resolution Fly's Eye Experiment

    CERN Document Server

    Abu-Zayyad, T; Allen, M; Anderson, R; Azuma, R; Barcikowski, E; Belz, J W; Bergman, D R; Blake, S A; Cady, R; Cheon, B G; Chiba, J; Chikawa, M; Cho, E J; Cho, W R; Fujii, H; Fujii, T; Fukuda, T; Fukushima, M; Gorbunov, D; Hanlon, W; Hayashi, K; Hayashi, Y; Hayashida, N; Hibino, K; Hiyama, K; Honda, K; Iguchi, T; Ikeda, D; Ikuta, K; Inoue, N; Ishii, T; Ishimori, R; Ivanov, D; Iwamoto, S; Jui, C C H; Kadota, K; Kakimoto, F; Kalashev, O; Kanbe, T; Kasahara, K; Kawai, H; Kawakami, S; Kawana, S; Kido, E; Kim, H B; Kim, H K; Kim, J H; Kim, J H; Kitamoto, K; Kitamura, S; Kitamura, Y; Kobayashi, K; Kobayashi, Y; Kondo, Y; Kuramoto, K; Kuzmin, V; Kwon, Y J; Lim, S I; Machida, S; Martens, K; Martineau, J; Matsuda, T; Matsuura, T; Matsuyama, T; Matthews, J N; Minamino, M; Miyata, K; Murano, Y; Nagataki, S; Nakamura, T; Nam, S W; Nonaka, T; Ogio, S; Ohnishi, M; Ohoka, H; Oki, K; Oku, D; Okuda, T; Oshima, A; Ozawa, S; Park, I H; Pshirkov, M S; Rodriguez, D C; Roh, S Y; Rubtsov, G; Ryu, D; Sagawa, H; Sakurai, N; Sampson, A L; Scott, L M; Shah, P D; Shibata, F; Shibata, T; Shimodaira, H; Shin, B K; Shin, J I; Shirahama, T; Smith, J D; Sokolsky, P; Sonley, T J; Springer, R W; Stokes, B T; Stratton, S R; Stroman, T; Suzuki, S; Takahashi, Y; Takeda, M; Taketa, A; Takita, M; Tameda, Y; Tanaka, H; Tanaka, K; Tanaka, M; Thomas, S B; Thomson, G B; Tinyakov, P; Tkachev, I; Tokuno, H; Tomida, T; Troitsky, S; Tsunesada, Y; Tsutsumi, K; Tsuyuguchi, Y; Uchihori, Y; Udo, S; Ukai, H; Vasiloff, G; Wada, Y; Wong, T; Wood, M; Yamakawa, Y; Yamane, R; Yamaoka, H; Yamazaki, K; Yang, J; Yoneda, Y; Yoshida, S; Yoshii, H; Zollinger, R; Zundel, Z

    2012-01-01

    The Telescope Array's Middle Drum fluorescence detector was instrumented with telescopes refurbished from the High Resolution Fly's Eye's HiRes-1 site. The data observed by Middle Drum in monocular mode was analyzed via the HiRes-1 profile-constrained geometry reconstruction technique and utilized the same calibration techniques enabling a direct comparison of the energy spectra and energy scales between the two experiments. The spectrum measured using the Middle Drum telescopes is based on a three-year exposure collected between December 16, 2007 and December 16, 2010. The calculated difference between the spectrum of the Middle Drum observations and the published spectrum obtained by the data collected by the HiRes-1 site allows the HiRes-1 energy scale to be transferred to Middle Drum. The HiRes energy scale is applied to the entire Telescope Array by making a comparison between Middle Drum monocular events and hybrid events that triggered both Middle Drum and the Telescope Array's scintillator Ground Arra...

  19. Results for the Independent Sampling and Analysis of Used Oil Drums at the Impact Services Facility in Oak Ridge, TN

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-04-25

    The U.S. Department of Energy (DOE) requested that Oak Ridge Associated Universities (ORAU), via the Oak Ridge Institute for Science and Education (ORISE) contract, perform independent sampling and analysis of used oils contained within eight 55 gallon drums stored at the former IMPACT Services facility, located at the East Tennessee Technology Park in Oak Ridge, Tennessee. These drums were originally delivered by LATA Sharp Remediation Services (LSRS) to IMPACT Services on January 11, 2011 as part of the Bldg. K-33 demolition project, and the drums plus contents should have been processed as non-hazardous non-radiological waste by IMPACT Services. LSRS received a certificate of destruction on August 29, 2012 (LSRS 2012a). However, IMPACT Services declared bankruptcy and abandoned the site later in 2012, and eight of the original eleven K-33 drums are currently stored at the facility. The content of these drums is the subject of this investigation. The original drum contents were sampled by LSRS in 2010 and analyzed for gross alpha, gross beta, and polychlorinated biphenyls (PCBs), using both compositing and grab sampling techniques. The objective of this 2013 sample and analysis effort was to duplicate, to the extent possible, the 2010 sampling and analysis event to support final disposition decisions. Part of that decision process includes either verifying or refuting the assertion that oils that are currently stored in drums at the IMPACT Services facility originated from Bldg. K-33 equipment.

  20. Granular avalanches in a two-dimensional rotating drum with imposed vertical vibration.

    Science.gov (United States)

    Amon, Daniel L; Niculescu, Tatiana; Utter, Brian C

    2013-07-01

    We present statistics on granular avalanches in a rotating drum with and without imposed vertical vibration. The experiment consists of a quasi-two-dimensional, vertical drum containing pentagonal particles and rotated at a constant angular velocity. The drum rests on an electromagnetic shaker to allow vibration of the assembly as it rotates. We measure time series of the slope of the interface and find that the critical angle for slope failure θ(c) and the resulting angle of repose θ(r) are broadly distributed with an approximate power-law distribution of avalanches θ(c)-θ(r) for large avalanches. The faceted pentagonal grains used lead to significant interlocking with critical and repose angles (θ(c)≈45° and θ(r)≈39°) larger than experiments using spherical grains, even with vibration, and avalanche magnitudes correlated with the prior build-up and anti-correlated with the prior avalanche. We find that the stability of the assembly increases with small vibrations and is destabilized at vibration amplitudes above a dimensionless acceleration (peak acceleration divided by acceleration due to gravity) of Γ=0.2. We also study history dependence of the avalanches by periodically oscillating the drum to compare the initial avalanche upon reversal of shear to steady-state distributions for avalanches during continuous rotation. We observe history dependence as an initial decrease in critical angle upon reversal of the drum rotation direction, indicating that a texture is induced to resist continued shear such that the surface is weaker to reversals in shear direction. Memory of this history is removed by sufficient external vibration (Γ≥0.8), which leads to compaction and relaxation of the surface layer grains responsible for avalanching dynamics, as initial and steady-state avalanche distributions become indistinguishable.

  1. Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

    Directory of Open Access Journals (Sweden)

    Garcia Juan L

    2010-08-01

    Full Text Available Abstract Background Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. Even in those patients with low-grade gliomas, that imply a moderately good prognosis, treatment is almost never curative. Recent studies have demonstrated the existence of a small fraction of glioma cells with characteristics of neural stem cells which are able to grow in vitro forming neurospheres and that can be isolated in vivo using surface markers such as CD133. The aim of this study was to define the molecular signature of GBM cells expressing CD133 in comparison with non expressing CD133 cells. This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM. Methods Eight fresh, primary and non cultured GBMs were used in order to study the gene expression signatures from its CD133 positive and negative populations isolated by FACS-sorting. Dataset was generated with Affymetrix U133 Plus 2 arrays and analysed using the software of the Affymetrix Expression Console. In addition, genomic analysis of these tumours was carried out by CGH arrays, FISH studies and MLPA; Results Gene expression analysis of CD133+ vs. CD133- cell population from each tumour showed that CD133+ cells presented common characteristics in all glioblastoma samples (up-regulation of genes involved in angiogenesis, permeability and down-regulation of genes implicated in cell assembly, neural cell organization and neurological disorders. Furthermore, unsupervised clustering of gene expression led us to distinguish between two groups

  2. The xylan utilization system of the plant pathogen Xanthomonas campestris pv campestris controls epiphytic life and reveals common features with oligotrophic bacteria and animal gut symbionts.

    Science.gov (United States)

    Déjean, Guillaume; Blanvillain-Baufumé, Servane; Boulanger, Alice; Darrasse, Armelle; Dugé de Bernonville, Thomas; Girard, Anne-Laure; Carrére, Sébastien; Jamet, Stevie; Zischek, Claudine; Lautier, Martine; Solé, Magali; Büttner, Daniela; Jacques, Marie-Agnès; Lauber, Emmanuelle; Arlat, Matthieu

    2013-05-01

    Xylan is a major structural component of plant cell wall and the second most abundant plant polysaccharide in nature. Here, by combining genomic and functional analyses, we provide a comprehensive picture of xylan utilization by Xanthomonas campestris pv campestris (Xcc) and highlight its role in the adaptation of this epiphytic phytopathogen to the phyllosphere. The xylanolytic activity of Xcc depends on xylan-deconstruction enzymes but also on transporters, including two TonB-dependent outer membrane transporters (TBDTs) which belong to operons necessary for efficient growth in the presence of xylo-oligosaccharides and for optimal survival on plant leaves. Genes of this xylan utilization system are specifically induced by xylo-oligosaccharides and repressed by a LacI-family regulator named XylR. Part of the xylanolytic machinery of Xcc, including TBDT genes, displays a high degree of conservation with the xylose-regulon of the oligotrophic aquatic bacterium Caulobacter crescentus. Moreover, it shares common features, including the presence of TBDTs, with the xylan utilization systems of Bacteroides ovatus and Prevotella bryantii, two gut symbionts. These similarities and our results support an important role for TBDTs and xylan utilization systems for bacterial adaptation in the phyllosphere, oligotrophic environments and animal guts.

  3. Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.

    Science.gov (United States)

    Zhang, Weihua; Jernerén, Fredrik; Lehne, Benjamin C; Chen, Ming-Huei; Luben, Robert N; Johnston, Carole; Elshorbagy, Amany; Eppinga, Ruben N; Scott, William R; Adeyeye, Elizabeth; Scott, James; Böger, Rainer H; Khaw, Kay-Tee; van der Harst, Pim; Wareham, Nicholas J; Vasan, Ramachandran S; Chambers, John C; Refsum, Helga; Kooner, Jaspal S

    2016-11-30

    L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. We performed a genome-wide association study (GWAS) to identify genetic factors determining serum L-arginine levels, amongst 901 Europeans and 1,394 Indian Asians. We show that common genetic variations at the KLKB1 and F12 loci are strongly associated with serum L-arginine levels. The G allele of single nucleotide polymorphism (SNP) rs71640036 (T/G) in KLKB1 is associated with lower serum L-arginine concentrations (10 µmol/l per allele copy, p=1×10(-24)), while allele T of rs2545801 (T/C) near the F12 gene is associated with lower serum L-arginine levels (7 µmol/l per allele copy, p=7×10(-12)). Together these two loci explain 7 % of the total variance in serum L-arginine concentrations. The associations at both loci were replicated in independent cohorts with plasma L-arginine measurements (pL-arginine and its potential relationship with cardiovascular risk.

  4. Mutational analysis of the PITX2 coding region revealed no common cause for transposition of the great arteries (dTGA

    Directory of Open Access Journals (Sweden)

    Goldmuntz Elizabeth

    2005-05-01

    Full Text Available Abstract Background PITX2 is a bicoid-related homeodomain transcription factor that plays an important role in asymmetric cardiogenesis. Loss of function experiments in mice cause severe heart malformations, including transposition of the great arteries (TGA. TGA accounts for 5–7% of all congenital heart diseases affecting 0.2 per 1000 live births, thereby representing the most frequent cyanotic heart defect diagnosed in the neonatal period. Methods To address whether altered PITX2 function could also contribute to the formation of dTGA in humans, we screened 96 patients with dTGA by means of dHPLC and direct sequencing for mutations within the PITX2 gene. Results Several SNPs could be detected, but no stop or frame shift mutation. In particular, we found seven intronic and UTR variants, two silent mutations and two polymorphisms within the coding region. Conclusion As most sequence variants were also found in controls we conclude that mutations in PITX2 are not a common cause of dTGA.

  5. Detailed analysis of seed coat and cotyledon reveals molecular understanding of the hard-to-cook defect of common beans (Phaseolus vulgaris L.).

    Science.gov (United States)

    Yi, Jianyong; Njoroge, Daniel M; Sila, Daniel N; Kinyanjui, Peter K; Christiaens, Stefanie; Bi, Jinfeng; Hendrickx, Marc E

    2016-11-01

    The hard-to-cook (HTC) defect in legumes is characterized by the inability of cotyledons to soften during the cooking process. Changes in the non-starch polysaccharides of common bean seed coat and cotyledon were studied before and after development of the HTC defect induced by storage at 35°C and 75% humidity for 8months. Distinct differences in the yields of alcohol insoluble residues, degree of methoxylation (DM), sugar composition, and molar mass distribution of non-starch polysaccharides were found between the seeds coat and cotyledons. The non-starch polysaccharide profiles, both for seed coats and cotyledons, significantly differed when comparing HTC and easy-to-cook (ETC) beans. In conclusion, differences in the structure, composition and extractability of non-starch polysaccharides between the ETC and HTC beans confirmed the significant role of pectin polysaccharides in interaction with divalent ions in the HTC development, which consequently affect their cooking behaviors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Epigenetic analyses and the distribution of repetitive DNA and resistance genes reveal the complexity of common bean (Phaseolus vulgaris L., Fabaceae) heterochromatin.

    Science.gov (United States)

    Fonsêca, Artur; Richard, Manon M S; Geffroy, Valérie; Pedrosa-Harand, Andrea

    2014-01-01

    The common bean (Phaseolus vulgaris L.) is the main representative of its genus and one of most important sources of proteins in African and Latin American countries. Although it is a species with a small genome, its pericentromeric and subtelomeric heterochromatin fractions are interspersed with single-copy sequences and active genes, suggesting a less compartmentalized genome organization. The present study characterized its chromatin fractions, associating the distribution of repetitive sequences and resistance genes with histone and DNA epigenetic modifications with and without biotic stress. Immunostaining with H3K4me3 and H4K5ac were generally associated with euchromatic regions, whereas H3K9me2, H3K27me1, and 5mC preferentially labeled the pericentromeric heterochromatin. The 45S rDNA and centromeric DNA sequences were hypomethylated as were most of the terminal heterochromatic blocks. The largest of them, which is associated with resistance genes, was also hypomethylated after the plants were infected with virulent and avirulent strains of the fungus Colletotrichum lindemuthianum, suggesting no correlation with control of resistance gene expression. The results highlighted the differences between subtelomeric and pericentromeric heterochromatin as well as variation within the pericentromeric heterochromatin. © 2014 S. Karger AG, Basel.

  7. Mitochondrial genome of the homoscleromorph Oscarella carmela (Porifera, Demospongiae) reveals unexpected complexity in the common ancestor of sponges and other animals.

    Science.gov (United States)

    Wang, Xiujuan; Lavrov, Dennis V

    2007-02-01

    Homoscleromorpha is a small group in the phylum Porifera (Sponges) characterized by several morphological features (basement membrane, acrosomes in spermatozoa, and cross-striated rootlets of the flagellar basal apparatus) shared with eumetazoan animals but not found in most other sponges. To clarify the phylogenetic position of this group, we determined and analyzed the complete mitochondrial DNA (mtDNA) sequence of the homoscleromorph sponge Oscarella carmela (Porifera, Demospongiae). O. carmela mtDNA is 20,327 bp and contains the largest complement of genes reported for animal mtDNA, including a putative gene for the C subunit of the twin-arginine translocase (tatC) that has never been found in animal mtDNA. The genes in O. carmela mtDNA are arranged in 2 clusters with opposite transcriptional orientations, a gene arrangement reminiscent of those in several cnidarian mtDNAs but unlike those reported in sponges. At the same time, phylogenetic analyses based on concatenated amino acid sequences from 12 mitochondrial (mt) protein genes strongly support the phylogenetic affinity between the Homoscleromorpha and other demosponges. Altogether, our data suggest that homoscleromorphs are demosponges that have retained ancestral features in both mt genome and morphological organization lost in other taxa and that the most recent common ancestor of sponges and other animals was morphologically and genetically more complex than previously thought.

  8. Epidemiological Characteristics and Clinical Treatment Outcome of Typhoid Fever in Ningbo, China, 2005-2014: Pulsed-Field Gel Electorophoresis Results Revealing Great Proportion of Common Transmission Sources.

    Science.gov (United States)

    Song, Qifa; Yang, Yuanbin; Lin, Wenping; Yi, Bo; Xu, Guozhang

    2017-09-25

    We aimed to describe the molecular epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo, China during 2005-2014. Eighty-eight Salmonella Typhi isolates were obtained from 307 hospitalized patients. Three prevalent pulsed-field gel electrophoresis (PFGE) patterns of 54 isolates from 3 outbreaks were identified. Overall, there were 64 (72.7%) isolates from clustered cases and 24 (27.3%) isolates from sporadic cases. Resistance to nalidixic acid (NAL) (n = 47; 53.4%) and ampicillin (AMP) (n = 40; 45.4%) and rare resistance to tetracycline (TET) (n = 2; 2.3%) and gentamicin (GEN) (n = 2; 2.3%) were observed. No isolates resistant to cefotaxime (CTX), chloramphenicol (CL), ciprofloxacin (CIP), and trimethoprim-sulfamethoxazole (SXT) were found. The occurrence of reduced sensitivity to CIP was 52.3% (n = 46). The medians of fever clearance time in cases with and without complications were 7 (interquartile range (IQR): 4-10) and 5 (IQR: 3-7) days (P = 0.001), respectively, when patients were treated with CIP or levofloxacin (LEV) and/or third-generation cephalosporins (CEP). Rates of serious complications were at low levels: peritonitis (2.3%), intestinal hemorrhage (6.8%), and intestinal perforation (1.1%). The present study revealed a long-term clustering trend with respect to PFGE patterns, occasional outbreaks, and the rapid spread of AMP resistance and decreased CIP susceptibility among S. Typhi isolates in recent years.

  9. Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.

    Directory of Open Access Journals (Sweden)

    Yofre Cabeza-Arvelaiz

    Full Text Available The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT has been linked to Parkinson disease (PD etiology and is often used to model this neurodegenerative disease (ND. Many of the mechanisms of action of rotenone are posited mechanisms of neurodegeneration; however, they are not fully understood. Therefore, the study of rotenone-affected functional pathways is pertinent to the understanding of NDs pathogenesis. This report describes the transcriptome analysis of a neuroblastoma (NB cell line chronically exposed to marginally toxic and moderately toxic doses of rotenone. The results revealed a complex pleiotropic response to rotenone that impacts a variety of cellular events, including cell cycle, DNA damage response, proliferation, differentiation, senescence and cell death, which could lead to survival or neurodegeneration depending on the dose and time of exposure and cell phenotype. The response encompasses an array of physiological pathways, modulated by transcriptional and epigenetic regulatory networks, likely activated by homeostatic alterations. Pathways that incorporate the contribution of MT destabilization to rotenone toxicity are suggested to explain complex I-independent rotenone-induced alterations of metabolism and redox homeostasis. The postulated mechanisms involve the blockage of mitochondrial voltage-dependent anions channels (VDACs by tubulin, which coupled with other rotenone-induced organelle dysfunctions may underlie many presumed neurodegeneration mechanisms associated with pathophysiological aspects of various NDs including PD, AD and their variant forms. Thus, further investigation of such pathways may help identify novel therapeutic paths for these NDs.

  10. Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks

    Directory of Open Access Journals (Sweden)

    Zarnescu Daniela C

    2008-11-01

    Full Text Available Abstract Background In Drosophila, the genes sticky and dFmr1 have both been shown to regulate cytoskeletal dynamics and chromatin structure. These genes also genetically interact with Argonaute family microRNA regulators. Furthermore, in mammalian systems, both genes have been implicated in neuronal development. Given these genetic and functional similarities, we tested Drosophila sticky and dFmr1 for a genetic interaction and measured whole genome expression in both mutants to assess similarities in gene regulation. Results We found that sticky mutations can dominantly suppress a dFmr1 gain-of-function phenotype in the developing eye, while phenotypes produced by RNAi knock-down of sticky were enhanced by dFmr1 RNAi and a dFmr1 loss-of-function mutation. We also identified a large number of transcripts that were misexpressed in both mutants suggesting that sticky and dFmr1 gene products similarly regulate gene expression. By integrating gene expression data with a protein-protein interaction network, we found that mutations in sticky and dFmr1 resulted in misexpression of common gene networks, and consequently predicted additional specific phenotypes previously not known to be associated with either gene. Further phenotypic analyses validated these predictions. Conclusion These findings establish a functional link between two previously unrelated genes. Microarray analysis indicates that sticky and dFmr1 are both required for regulation of many developmental genes in a variety of cell types. The diversity of transcripts regulated by these two genes suggests a clear cause of the pleiotropy that sticky and dFmr1 mutants display and provides many novel, testable hypotheses about the functions of these genes. As both of these genes are implicated in the development and function of the mammalian brain, these results have relevance to human health as well as to understanding more general biological processes.

  11. The genome of the amoeba symbiont "Candidatus Amoebophilus asiaticus" reveals common mechanisms for host cell interaction among amoeba-associated bacteria.

    Science.gov (United States)

    Schmitz-Esser, Stephan; Tischler, Patrick; Arnold, Roland; Montanaro, Jacqueline; Wagner, Michael; Rattei, Thomas; Horn, Matthias

    2010-02-01

    Protozoa play host for many intracellular bacteria and are important for the adaptation of pathogenic bacteria to eukaryotic cells. We analyzed the genome sequence of "Candidatus Amoebophilus asiaticus," an obligate intracellular amoeba symbiont belonging to the Bacteroidetes. The genome has a size of 1.89 Mbp, encodes 1,557 proteins, and shows massive proliferation of IS elements (24% of all genes), although the genome seems to be evolutionarily relatively stable. The genome does not encode pathways for de novo biosynthesis of cofactors, nucleotides, and almost all amino acids. "Ca. Amoebophilus asiaticus" encodes a variety of proteins with predicted importance for host cell interaction; in particular, an arsenal of proteins with eukaryotic domains, including ankyrin-, TPR/SEL1-, and leucine-rich repeats, which is hitherto unmatched among prokaryotes, is remarkable. Unexpectedly, 26 proteins that can interfere with the host ubiquitin system were identified in the genome. These proteins include F- and U-box domain proteins and two ubiquitin-specific proteases of the CA clan C19 family, representing the first prokaryotic members of this protein family. Consequently, interference with the host ubiquitin system is an important host cell interaction mechanism of "Ca. Amoebophilus asiaticus". More generally, we show that the eukaryotic domains identified in "Ca. Amoebophilus asiaticus" are also significantly enriched in the genomes of other amoeba-associated bacteria (including chlamydiae, Legionella pneumophila, Rickettsia bellii, Francisella tularensis, and Mycobacterium avium). This indicates that phylogenetically and ecologically diverse bacteria which thrive inside amoebae exploit common mechanisms for interaction with their hosts, and it provides further evidence for the role of amoebae as training grounds for bacterial pathogens of humans.

  12. Development and Application of a Blastocystis Subtype-Specific PCR Assay Reveals that Mixed-Subtype Infections Are Common in a Healthy Human Population.

    Science.gov (United States)

    Scanlan, Pauline D; Stensvold, Christen Rune; Cotter, Paul D

    2015-06-15

    The human gut is host to a diversity of microorganisms, including the single-celled microbial eukaryote Blastocystis. Research has shown that most carriers host a single Blastocystis subtype (ST), which is unusual given the considerable within-host species diversity observed for other microbial genera in this ecosystem. However, our limited knowledge of both the incidence and biological significance of Blastocystis diversity within hosts (i.e., so-called mixed infections) is likely due to problems with existing methodologies. Here, we developed and applied Blastocystis ST-specific PCRs for the investigation of the most common subtypes of Blastocystis (ST1 to ST4) to a healthy human cohort (n = 50). We detected mixed infections in 22% of the cases, all of which had been identified as single-ST infections in a previous study using state-of-the-art methods. Our results show that certain STs occur predominantly as either single (ST3 and 4) or mixed (ST1) infections, which may reflect inter alia transient colonization patterns and/or cooperative or competitive interactions between different STs. Comparative analyses with other primers that have been used extensively for ST-specific analysis found them unsuitable for detection of mixed- and, in some cases, single-ST infections. Collectively, our data shed new light on the diversity of Blastocystis within and between human hosts. Moreover, the development of these PCR assays will facilitate future work on the molecular epidemiology and significance of mixed infections in groups of interest, including health and disease cohorts, and also help identify sources of Blastocystis transmission to humans, including identifying potential animal and environmental reservoirs. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  13. Metabolomic analysis reveals a common pattern of metabolic re-programming during invasion of three host plant species by Magnaporthe grisea.

    Science.gov (United States)

    Parker, David; Beckmann, Manfred; Zubair, Hassan; Enot, David P; Caracuel-Rios, Zaira; Overy, David P; Snowdon, Stuart; Talbot, Nicholas J; Draper, John

    2009-09-01

    The mechanisms by which biotrophic and hemi-biotrophic fungal pathogens simultaneously subdue plant defences and sequester host nutrients are poorly understood. Using metabolite fingerprinting, we show that Magnaporthe grisea, the causal agent of rice blast disease, dynamically re-programmes host metabolism during plant colonization. Identical patterns of metabolic change occurred during M. grisea infections in barley, rice and Brachypodium distachyon. Targeted metabolite profiling by GC-MS confirmed the modulation of a conserved set of metabolites. In pre-symptomatic tissues, malate and polyamines accumulated, rather than being utilized to generate defensive reactive oxygen species, and the levels of metabolites associated with amelioration of redox stress in various cellular compartments increased dramatically. The activity of NADP-malic enzyme and generation of reactive oxygen species were localized to pathogen penetration sites, and both appeared to be suppressed in compatible interactions. Early diversion of the shikimate pathway to produce quinate was observed, as well as accumulation of non-polymerized lignin precursors. These data are consistent with modulation of defensive phenylpropanoid metabolism by M. grisea and the inability of susceptible hosts to mount a hypersensitive reaction or produce lignified papillae (both involving reactive oxygen species) to restrict pathogen invasion. Rapid proliferation of M. grisea hyphae in plant tissue after 3 days was associated with accelerated nutrient acquisition and utilization by the pathogen. Conversion of photoassimilate into mannitol and glycerol for carbon sequestration and osmolyte production appear to drive hyphal growth. Taken together, our results suggest that fungal pathogens deploy a common metabolic re-programming strategy in diverse host species to suppress plant defence and colonize plant tissue.

  14. Transcriptome analysis reveals common differential and global gene expression profiles in bluetongue virus serotype 16 (BTV-16 infected peripheral blood mononuclear cells (PBMCs in sheep and goats

    Directory of Open Access Journals (Sweden)

    Anjali Singh

    2017-03-01

    Full Text Available Bluetongue is an economically important infectious, arthropod borne viral disease of domestic and wild ruminants, caused by Bluetongue virus (BTV. Sheep are considered the most susceptible hosts, while cattle, buffalo and goats serve as reservoirs. The viral pathogenesis of BTV resulting in presence or absence of clinical disease among different hosts is not clearly understood. In the present study, transcriptome of sheep and goats peripheral blood mononuclear cells infected with BTV-16 was explored. The differentially expressed genes (DEGs identified were found to be significantly enriched for immune system processes - NFκB signaling, MAPK signaling, Ras signaling, NOD signaling, RIG signaling, TNF signaling, TLR signaling, JAK-STAT signaling and VEGF signaling pathways. Greater numbers of DEGs were found to be involved in immune system processes in goats than in sheep. Interestingly, the DEHC (differentially expressed highly connected gene network was found to be dense in goats than in sheep. Majority of the DEHC genes in the network were upregulated in goats but down-regulated in sheep. The network of differentially expressed immune genes with the other genes further confirmed these findings. Interferon stimulated genes - IFIT1 (ISG56, IFIT2 (ISG54 and IFIT3 (ISG60 responsible for antiviral state in the host were found to be upregulated in both the species. STAT2 was the TF commonly identified to co-regulate the DEGs, with its network showing genes that are downregulated in sheep but upregulated in goats. The genes dysregulated and the networks perturbed in the present study indicate host variability with a positive shift in immune response to BTV in goats than in sheep.

  15. Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma.

    Directory of Open Access Journals (Sweden)

    Armand Valsesia

    Full Text Available Cancer genomes frequently contain somatic copy number alterations (SCNA that can significantly perturb the expression level of affected genes and thus disrupt pathways controlling normal growth. In melanoma, many studies have focussed on the copy number and gene expression levels of the BRAF, PTEN and MITF genes, but little has been done to identify new genes using these parameters at the genome-wide scale. Using karyotyping, SNP and CGH arrays, and RNA-seq, we have identified SCNA affecting gene expression ('SCNA-genes' in seven human metastatic melanoma cell lines. We showed that the combination of these techniques is useful to identify candidate genes potentially involved in tumorigenesis. Since few of these alterations were recurrent across our samples, we used a protein network-guided approach to determine whether any pathways were enriched in SCNA-genes in one or more samples. From this unbiased genome-wide analysis, we identified 28 significantly enriched pathway modules. Comparison with two large, independent melanoma SCNA datasets showed less than 10% overlap at the individual gene level, but network-guided analysis revealed 66% shared pathways, including all but three of the pathways identified in our data. Frequently altered pathways included WNT, cadherin signalling, angiogenesis and melanogenesis. Additionally, our results emphasize the potential of the EPHA3 and FRS2 gene products, involved in angiogenesis and migration, as possible therapeutic targets in melanoma. Our study demonstrates the utility of network-guided approaches, for both large and small datasets, to identify pathways recurrently perturbed in cancer.

  16. A conserved role for the NAM/miR164 developmental module reveals a common mechanism underlying carpel margin fusion in monocarpous and syncarpous eurosids.

    Directory of Open Access Journals (Sweden)

    Aurelie Chantal Marie Vialette-Guiraud

    2016-01-01

    Full Text Available The majority of angiosperms are syncarpous- their gynoecium is composed of two or more fused carpels. In Arabidopsis thaliana, this fusion is regulated through the balance of expression between CUP SHAPED COTYLEDON (CUC genes, which are orthologues of the Petunia hybrida transcription factor NO APICAL MERISTEM (NAM, and their post-transcriptional regulator miR164. Accordingly, the expression of a miR164-insensitive form of Ar. thaliana CUC2 causes a radical breakdown of carpel fusion. Here, we investigate the role of the NAM/miR164 genetic module in carpel closure in monocarpous plants. We show that the disruption of this module in monocarpous flowers of Ar. thaliana aux1-22 mutants causes a failure of carpel closure, similar to the failure of carpel fusion observed in the wild-type genetic background. This observation suggested that closely related mechanisms may bring about carpel closure and carpel fusion, at least in Ar. thaliana. We therefore tested whether these mechanisms were conserved in a eurosid species that is monocarpous in its wild-type form. We observed that expression of MtNAM, the NAM ortholog in the monocarpous eurosid Medicago truncatula, decreases during carpel margin fusion, suggesting a role for the NAM/miR164 module in this process. We transformed M. truncatula with a miR164-resistant form of MtNAM and observed, among other phenotypes, incomplete carpel closure in the resulting transformants. These data confirm the underlying mechanistic similarity between carpel closure and carpel fusion which we observed in Ar. thaliana. Our observations suggest that the role of the NAM/miR164 module in the fusion of carpel margins has been conserved at least since the most recent common ancestor of the eurosid clade, and open the possibility that a similar mechanism may have been responsible for carpel closure at much earlier stages of angiosperm evolution. We combine our results with studies of early-diverging angiosperms to speculate

  17. 凤阳花鼓的嬗变及其音乐特点探析%Study on Music Feature and Development of Fengyang Flower-drum Dance

    Institute of Scientific and Technical Information of China (English)

    李小舒

    2015-01-01

    梳理了安徽"凤阳花鼓"艺术的兴起、发展和演变历程,从音乐结构、旋律进行和词曲关系等方面分析流传于20世纪30年代的凤阳歌《凤阳花鼓》和清代康熙年间的《凤阳歌》. 认为这两首产生于不同时代的小曲具有同属于五声调式、由AB两个乐段构成、旋律多级进、腔词关系以一字一音为主、节奏简洁等共性特征.%The artistic rising ,development and evolution of Fengyang Flower-drum Dance were analyzed , and melody progress and lyric relationship were also studied from music structure in this paper .It ana-lyzed Fengyang Flower-drum Dance in 1930s and Fengyang Song of Kangxi Period of Qing Dynasty .The two songs have the following in common from different period such as they are belong to pentatonic scale , and are composed of A & B period .The two songs have progressive melody and concise rhythm ,mainly with one-word-one-sound aria lyric relationship .

  18. Variant Timekeeping Patterns and Their Effects in Jazz Drumming

    National Research Council Canada - National Science Library

    Butterfield, Matthew W

    2010-01-01

    ...." This essay shows how one modern jazz drummer employs variants of common timekeeping patterns in a more "liquid" way to generate motional energy through the strategic production of metric dissonance...

  19. Metrological tests of a 200 L calibration source for HPGE detector systems for assay of radioactive waste drums.

    Science.gov (United States)

    Boshkova, T; Mitev, K

    2016-03-01

    In this work we present test procedures, approval criteria and results from two metrological inspections of a certified large volume (152)Eu source (drum about 200L) intended for calibration of HPGe gamma assay systems used for activity measurement of radioactive waste drums. The aim of the inspections was to prove the stability of the calibration source during its working life. The large volume source was designed and produced in 2007. It consists of 448 identical sealed radioactive sources (modules) apportioned in 32 transparent plastic tubes which were placed in a wooden matrix which filled the drum. During the inspections the modules were subjected to tests for verification of their certified characteristics. The results show a perfect compliance with the NIST basic guidelines for the properties of a radioactive certified reference material (CRM) and demonstrate the stability of the large volume CRM-drum after 7 years of operation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. An analysis of thermionic space nuclear reactor power system: II. Merits of using safety drums for backup control

    Science.gov (United States)

    El-Genk, Mahomed S.; Xue, Huimin

    1993-01-01

    An analysis is performed to investigate the merits of using the TOPAZ-II safety drums for a backup control to prevent a reactivity excursion, stabilize the reactor, and achieve steady-state power operation, following a severe hypothetical reactivity initiated accident (RIA). Such an RIA is assumed to occur during the system start-up in orbit due to a malfunction of the drive mechanism of the control drums, causing the nine drums to accidentally rotate the full 180° outward. Results show that an immediate, inward rotation of the three safety drums to an angle of 80° will shutdown the reactor, however, a delay time of 10 s will not only prevents a reactivity excursion, but also enables operating the reactor at a steady-state thermal power of about 33.3 kW (0.9 kW per TFE). Conversely, when the immediate rotation of the safety drums is to a larger angle of 100°, a steady-state operation at about 37 kW can be achieved, but a delay of 10 s causes a reactivity excursion and overheating of the TFEs. It is therefor concluded that, should the drive mechanism be modified to enable rotating the safety drums for TOPAZ-II reactor at variable speeds of and below 22.5°/s, the three safety drums could be used successfully for a backup control, following an RIA. However, since the reactivity worth of the three safety drums is only 2.0, the maximum steady-state electric power achievable for the system is limited to approximately 0.25 kW, at which the fission power is about 37 kW and the emitter temperature is approximaely 1500 K. To alleviate such a limitation and enable operation at nominal design conditions (fission power of about 107 kW or a system's total electric power of 5.6 kW), the reactivity worth of the safety drums would have to be increased by at least 0.24. An additional increase in the safety drums' worth will also be necessary to maintain steady-state operation of the system at nominal conditions throughout the mission lifetime, with all nine control drums fully

  1. Safety evaluation for packaging (onsite) for the concrete-shielded RH TRU drum for the 327 Postirradiation Testing Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Smith, R.J.

    1998-03-31

    This safety evaluation for packaging authorizes onsite transport of Type B quantities of radioactive material in the Concrete Shielded Remote-Handled Transuranic Waste (RH TRU) Drum per HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments. The drum will be used for transport of 327 Building legacy waste from the 300 Area to a solid waste storage facility on the Hanford Site.

  2. Safety evaluation for packaging (onsite) for concrete-shielded RHTRU waste drum for the 327 postirradiation testing laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Adkins, H.E.

    1996-10-29

    This safety evaluation for packaging authorizes onsite transport of Type B quantities of radioactive material in the Concrete- Shielded Remote-Handled Transuranic Waste (RH TRU) Drum per WHC-CM-2-14, Hazardous Material Packaging and Shipping. The drum will be used for transport of 327 Building legacy waste from the 300 Area to the Transuranic Waste Storage and Assay Facility in the 200 West Area and on to a Solid Waste Storage Facility, also in the 200 Area.

  3. Pengembangan Reaktor Fotokatalitik Rotating Drum untuk Pengolahan Air Limbah Industri Tekstil

    Directory of Open Access Journals (Sweden)

    Cholid Syahroni

    2015-11-01

    Full Text Available Reaksi oksidasi fotokatalitik memiliki potensi untuk mendegradasi senyawa organik hingga tingkat mineralisasi, sehingga tidak meninggalkan residu (sludge. Penelitian ini bertujuan membuat reaktor fotokatalitik rotating drum dan mengaplikasikan pada industri tekstil. Langkah percobaan meliputi pembuatan katalis TiO2 secara anodizing serta karakterisasi dengan XRD dan SEM, pembuatan reaktor fotokatalitik  rotating drum dan uji coba degradasi air limbah industri tekstil. Proses anodizing dilakukan dengan bias potensial sebesar 40 volt selama 2 jam menggunakan elektrolit etilen glikol yang mengandung amonium fluorida dan air. Uji karakterisasi secara XRD dan SEM menunjukkan bahwa struktur kristal TiO2 adalah anatase dengan ukuran kristalit 8–19 nm. Bentuk kristal nanotube, dengan diameter 30–110 nm. Hasil uji coba menunjukkan bahwa  degradasi secara fotokatalitik dengan penambahan H2O2 0,15% terhadap air limbah bisa menurunkan COD 72,12% dalam waktu 2 jam. 

  4. Application of remote Raman screening to processing of mixed wastes in drums

    Science.gov (United States)

    Crawford, Beverly A.; Jewett, James R.; Parker, K. E.; Petersen, C. A.; Petty, Chris J.

    1993-12-01

    Transuranic (TRU) and low-level drum waste disposal involves decisions based on transportation restrictions, conditions for acceptance, and federal and state regulations. To support the decisions made concerning final disposition of these wastes, characterization protocols must be established to help define the environmental impact. One promising screening technique involves applying near infrared (IR) Fourier Transform Raman (FT- Raman) spectroscopy using remote fiber optic probes for identifying unknown salts, sludges, and solids in wastes. It is proposed that FT-Raman spectroscopy be used in conjunction with real-time radiography and visual documentation. Developing an extensive solid waste library is a key element in the deployment of this technology in the process environment of solid waste drums. The feasibility for such library generation is also demonstrated.

  5. Implementing a technique to improve the accuracy of shuffler assays of waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Rinard, P.M.

    1996-07-01

    The accuracy of shuffler assays for fissile materials is generally limited by the accuracy of the calibration standards, but when the matrix in a large drum has a sufficiently high hydrogen density (as exists in paper, for example) the accuracy in the active mode can be adversely affected by a nonuniform distribution of the fissile material within the matrix. This paper reports on a technique to determine the distribution nondestructively using delayed neutron signals generated by the shuffler itself. In assays employing this technique, correction factors are applied to the result of the conventional assay according to the distribution. Maximum inaccuracies in assays with a drum of paper, for example, are reduced by a factor of two or three.

  6. Portrayals of men and women in Drum magazine (South Africa) advertisements

    OpenAIRE

    Mlenga Jere

    2014-01-01

    Orientation: The subject of gender portrayals in advertising continues to generate academicdiscussions in part because of its socialisation effects.Research purpose: The purpose of this study is to determine how print advertisements inDrum magazine portray women and men based on a number of categories including traitdescriptors, physical characteristics, role behaviours and occupational status.Motivation for the study: It is important to understand gender portrayals in advertisingbecause perc...

  7. Fault Diagnosis of Demountable Disk-Drum Aero-Engine Rotor Using Customized Multiwavelet Method

    OpenAIRE

    Jinglong Chen; Yu Wang; Zhengjia He; Xiaodong Wang

    2015-01-01

    The demountable disk-drum aero-engine rotor is an important piece of equipment that greatly impacts the safe operation of aircraft. However, assembly looseness or crack fault has led to several unscheduled breakdowns and serious accidents. Thus, condition monitoring and fault diagnosis technique are required for identifying abnormal conditions. Customized ensemble multiwavelet method for aero-engine rotor condition identification, using measured vibration data, is developed in this paper. Fir...

  8. Simultaneous Thermal Analysis of WIPP and LANL Waste Drum Samples: A Preliminary Report

    Energy Technology Data Exchange (ETDEWEB)

    Wayne, David M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-19

    On Friday, February 14, 2014, an incident in P7R7 of the WIPP underground repository released radioactive material into the environment. The direct cause of the event was a breached transuranic (TRU) waste container, subsequently identified as Drum 68660. Photographic and other evidence indicates that the breach of 68660 was caused by an exothermic event. Subsequent investigations (Britt, 2015; Clark and Funk, 2015; Wilson et al., 2015; Clark, 2015) indicate that the combination of nitrate salts, pH neutralizing chemicals, and organic-based adsorbent represented a potentially energetic mixture. The materials inside the breached steel drum consisted of remediated, 30- to 40-year old, Pu processing wastes from LANL. The contents were processed and repackaged in 2014. Processing activities at LANL included: 1) neutralization of acidic liquid contents, 2) sorption of the neutralized liquid, and 3) mixing of acidic nitrate salts with an absorber to meet waste acceptance criteria. The contents of 68660 and its sibling, 68685, were derived from the same parent drum, S855793. Drum S855793 originally contained ten plastic bags of acidic nitrate salts, and four bags of mixed nitrate and oxalate salts generated in 1985 by Pu recovery operations. These salts were predominantly oxalic acid, hydrated nitrate salts of Mg, Ca, and Fe, anhydrous Na(NO3), and minor amounts of anhydrous and hydrous nitrate salts of Pb, Al, K, Cr, and Ni. Other major components include sorbed water, nitric acid, dissolved nitrates, an absorbent (Swheat Scoop®) and a neutralizer (KolorSafe®). The contents of 68660 are described in greater detail in Appendix E of Wilson et al. (2015)

  9. Corrosion susceptibility of steel drums to be used as containers for intermediate level nuclear waste

    Directory of Open Access Journals (Sweden)

    Duffó G.

    2013-07-01

    Full Text Available The present work is a study of the corrosion susceptibility of steel drums in contact with cemented ion-exchange resins contaminated with different types and concentrations of aggressive species. A special type of specimen was manufactured to simulate the cemented ion-exchange resins in the drum. The evolution of the corrosion potential and the corrosion rate of the steel, as well as the electrical resistivity of the matrix were monitored over a time period of 900 days. The aggressive species studied were chloride ions (the main ionic species of concern and sulphate ions (produced during radiolysis of the cationic exchange-resins after cementation. The work was complemented with an analysis of the corrosion products formed on the steel in each condition, as well as the morphology of the corrosion products. When applying the results obtained in the present work to estimate the corrosion depth of the steel drumscontaining the cemented radioactive waste after a period of 300 years (foreseen durability of the Intermediate Level Radioactive Waste facility in Argentina , it is found that in the most unfavourable case (high chloride contamination, the corrosion penetration will be considerably lower than the thickness of the wall of the steel drums.

  10. Do You Hear More Piano or Drum Sounds? An Auditory Version of the Solitaire Illusion.

    Science.gov (United States)

    Prpic, Valter; Luccio, Riccardo

    2016-10-03

    The solitaire illusion is an illusion of numerosity proposed by Frith and Frith. In the original version, an apparent number of elements was determined by the spatial arrangement of two kinds of elements (black and white marbles). In our study, an auditory version of the solitaire illusion was demonstrated. Participants were asked to judge if they perceived more drum or piano sounds. When half of the piano tones were perceived as lower in pitch than a drum sound and the other half higher, piano tones appeared to be arranged in small units, leading to numerosity underestimation. Conversely, when all piano tones were perceived to be higher in pitch than the drum sounds, they appeared to be arranged in a single large unit, leading to numerosity overestimation. Comparable to the visual version of the solitaire illusion, the clustering seems to be determined by Gestalt principles. In our auditory version, a clear reversal of the illusion (numerosity overestimation or underestimation) was observed when piano tones appeared to be arranged in a single large cluster or in several small clusters, respectively. © The Author(s) 2016.

  11. Carbon decomposition by inoculating Phanerochaete chrysosporium during drum composting of agricultural waste.

    Science.gov (United States)

    Varma, V Sudharsan; Ramu, Kamma; Kalamdhad, Ajay S

    2015-05-01

    The effect of Phanerochaete chrysosporium inoculation during drum composting of agricultural waste was performed at different composting stages. Three trials were carried out with (5:4:1) combination of vegetable waste, cattle manure, and sawdust along with 10 kg of dried leaves with a total mass of 100 kg in a 550 L rotary drum composter. Trial 1 was a control without inoculation of fungus, while trial 2 was inoculated during the initial day (0th day of composting), and trial 3 was inoculated after the thermophilic phase, i.e., on the 8th day of composting period. The inoculation of fungus increased the volatile solids reduction by 1.45-fold in trial 2 and 1.7-fold in trial 3 as compared to trial 1 without any fungal inoculation. Total Kjeldahl Nitrogen (TKN) was observed with 2.31, 2.62, and 2.59% in trials 1, 2, and 3, respectively, at the end of 20 days of composting period. Hence, it can be concluded that inoculation of white-rot fungus increased the decomposition rate of agricultural waste within shorter time in drum composting. However, inoculation after the thermophilic phase was found more effective than inoculation during initial days of composting for producing more stabilized and nutrient-rich compost.

  12. Motion sickness severity and physiological correlates during repeated exposures to a rotating optokinetic drum

    Science.gov (United States)

    Hu, Senqi; Grant, Wanda F.; Stern, Robert M.; Koch, Kenneth L.

    1991-01-01

    Fifty-two subjects were exposed to a rotating optokinetic drum. Ten of these subjects who became motion sick during the first session completed two additional sessions. Subjects' symptoms of motion sickness, perception of self-motion, electrogastrograms (EGGs), heart rate, mean successive differences of R-R intervals (RRI), and skin conductance were recorded for each session. The results from the first session indicated that the development of motion sickness was accompanied by increased EGG 4-9 cpm activity (gastric tachyarrhythmia), decreased mean succesive differences of RRI, increased skin conductance levels, and increased self-motion perception. The results from the subjects who had three repeated sessions showed that 4-9 cpm EGG activity, skin conductance levels, perception of self-motion, and symptoms of motion sickness all increased significantly during the drum rotation period of the first session, but increased significantly less during the following sessions. Mean successive differences of RRI decreased significantly during the drum rotation period for the first session, but decreased significantly less during the following sessions. Results show that the development of motion sickness is accompanied by an increase in gastric tachyarrhythmia, and an increase in sympathetic activity and a decrease in parasympathetic activity, and that adaptation to motion sickness is accompanied by the recovery of autonomic nervous system balance.

  13. Experimental Method for Analyzing Friction Phenomenon Related to Drum Brake Squeal

    Directory of Open Access Journals (Sweden)

    J. GLIŠOVIĆ

    2010-12-01

    Full Text Available Automobile brakes have been intensively developed during past few decades, but the maximum motor’s power, that should amortized in vehicle brakes, has been significantly increased also. Most of the kinetic energy of the moving vehicles is transforming into heat through friction. But the small part of kinetic energy transforms into sound pressure and makes noise. Low frequency squeal of drum brakes is very intense and can lead to customers’ complain. The interaction between the brake system and the vehicle framework and suspension is often very substantial during occurrence of brake noise. Unfortunately, to solve this type of squeal problem is also difficult because of the large number of components involved. The other cause is attributed to self-excited vibration that is induced when the friction material has a negative slope in relation to the relative velocity. This paper illustrates an approach to experimental studies of drum brakes in road conditions in order to monitor changes in the coefficient of friction that can generate drum brake squeal at low frequencies.

  14. Dietary nucleotides influence immune responses and intestinal morphology of red drum Sciaenops ocellatus.

    Science.gov (United States)

    Cheng, Zhenyan; Buentello, Alejandro; Gatlin, Delbert M

    2011-01-01

    Dietary nucleotides have been shown to benefit many physiological and nutritional functions in higher vertebrates and fish. Therefore, a 6-week feeding trial was conducted to evaluate the effects of graded levels of a commercial nucleotide product on growth performance, immune responses and intestinal morphology of juvenile red drum (initial average weight of 7.1g). The basal diet was formulated to contain 40% protein, 10% lipid and a digestible energy level of 3.5 kcal g(-1). Two levels of nucleotide (Ascogen P(®), 0.5% and 1% of diet) were added to the basal diet with menhaden fishmeal and menhaden oil adjusted to provide isonitrogenous and isolipidic diets. Nucleotide supplementation tended to improve weight gain and survival of red drum, but not at a significant level. Neutrophil oxidative radical anion production and serum lysozyme activity tended to be higher for fish fed diets supplemented with nucleotide, while extracellular superoxide anion production of head kidney macrophages from fish fed diets with 1% nucleotide was significantly (Pfish fed 0.5% nucleotide diet and the basal diet. Nucleotide supplementation significantly (Pfish fed with diets supplemented with nucleotides. It is therefore possible to use dietary nucleotides supplementation to significantly enhance the intestinal structure of red drum. Likewise, nucleotides in the diet may improve some components of the non-specific immune response of this sciaenid fish.

  15. Salt Composition Derived from Veazey Composition by Thermodynamic Modeling and Predicted Composition of Drum Contents

    Energy Technology Data Exchange (ETDEWEB)

    Weisbrod, Kirk Ryan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Funk, David John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Clark, David Lewis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-03-11

    This report describes the derivation of the salt composition from the Veazey salt stream analysis. It also provides an estimate of the proportions of the kitty litter, nitrate salt and neutralizer that was contained in drum 68660. While the actinide content of waste streams was judiciously followed in the 1980s in TA-55, no record of the salt composition could be found. Consequently, a salt waste stream produced from 1992 to 1994 and reported by Gerry Veazey provided the basis for this study. While chemical analysis of the waste stream was highly variable, an average analysis provided input to the Stream Analyzer software to calculate a composition for a concentrated solid nitrate salt and liquid waste stream. The calculation predicted the gas / condensed phase compositions as well as solid salt / saturated liquid compositions. The derived composition provides an estimate of the nitrate feedstream to WIPP for which kinetic measurements can be made. The ratio of salt to Swheat in drum 68660 contents was estimated through an overall mass balance on the parent and sibling drums. The RTR video provided independent confirmation concerning the volume of the mixture. The solid salt layer contains the majority of the salt at a ratio with Swheat that potentially could become exothermic.

  16. Common Warts

    Science.gov (United States)

    Diseases and Conditions Common warts By Mayo Clinic Staff Common warts are small, grainy skin growths that occur most often on your fingers or hands. Rough to the touch, common warts also often feature a pattern of tiny ...

  17. Development of phased array and tofd simultaneous inspection system for coke drum

    Energy Technology Data Exchange (ETDEWEB)

    Oka, M. [Sumitomo Heavy Industries, Ltd., Toyo Works, Quality Assurance Dept., Ehime (Japan); Kawashima, K. [S.H.I. Examination and Inspection, Ltd., Inspection and Engineering Dept., Ehime (Japan)

    2004-07-01

    Our current AUT (automatic ultrasonic testing) system is ''phased array linear scan and dual TOFD (time of fight diffraction) simultaneous inspection system'' which has been applied to the pre-service inspection at shop in lieu of radiography as per ASME Code case 2235-4 and the in-service inspection at user's turnaround stage for the circumferential and longitudinal weld joints of shell courses of coke drum. The coke drum is 13-30 feet in diameter and 80-100 feet in height. The base material of coke drum is either C-1/2Mo steel, 1Cr-1/2Mo steel, 1.25Cr-1/2Mo steel, or 2.25Cr-1Mo steel with type 410S or 405 stainless steel cladding material, and clad restoration weld material is either Inconel 82, Inconel 625 or same material as the cladding material (13Cr stainless steel). It is too difficult to detect the flaws in the clad restoration weld by the conventional manual UT and/or TOFD, but phased array can clearly detect them. In order to improve the capability to detect and size the low cycle fatigue crack caused in the clad restoration weld and its heat affected zone due to the cyclic operation of coke drum ''phased array sector scan'' has been adopted. This paper reports the verification test results of ''dual phased array sector scan'' (the simultaneous scanning by a pair of phased array probes placed equally for the centerline of weld joint) in comparison with the verification test results of TOFD, and introduces the characteristic of our current AUT system. In consideration with the verification test results in this paper, we would like to propose that ''dual phased array sector scan and dual TOFD simultaneous inspection system'' (the simultaneous inspection by four (4) kinds of AUT) will be applied to the in-service inspection for the coke drum and other important reactors overlaid inside by stainless steel or inconel at the oil refineries and/or petrochemical plants. (orig.)

  18. Analysis of heat conduction in a drum brake system of the wheeled armored personnel carriers

    Science.gov (United States)

    Puncioiu, A. M.; Truta, M.; Vedinas, I.; Marinescu, M.; Vinturis, V.

    2015-11-01

    This paper is an integrated study performed over the Braking System of the Wheeled Armored Personnel Carriers. It mainly aims to analyze the heat transfer process which is present in almost any industrial and natural process. The vehicle drum brake systems can generate extremely high temperatures under high but short duration braking loads or under relatively light but continuous braking. For the proper conduct of the special vehicles mission in rough terrain, we are talking about, on one hand, the importance of the possibility of immobilization and retaining position and, on the other hand, during the braking process, the importance movement stability and reversibility or reversibility, to an encounter with an obstacle. Heat transfer processes influence the performance of the braking system. In the braking phase, kinetic energy transforms into thermal energy resulting in intense heating and high temperature states of analyzed vehicle wheels. In the present work a finite element model for the temperature distribution in a brake drum is developed, by employing commercial finite element software, ANSYS. These structural and thermal FEA models will simulate entire braking event. The heat generated during braking causes distortion which modifies thermoelastic contact pressure distribution drum-shoe interface. In order to capture the effect of heat, a transient thermal analysis is performed in order to predict the temperature distribution transitional brake components. Drum brakes are checked both mechanical and thermal. These tests aim to establish their sustainability in terms of wear and the variation coefficient of friction between the friction surfaces with increasing temperature. Modeling using simulation programs led eventually to the establishment of actual thermal load of the mechanism of brake components. It was drawn the efficiency characteristic by plotting the coefficient of effectiveness relative to the coefficient of friction shoe-drum. Thus induced

  19. The acoustics of Japanese wooden drums called ``mokugyo''

    Science.gov (United States)

    Sunohara, Masahiro; Furihata, Kenji; Asano, David K.; Yanagisawa, Takesaburo; Yuasa, Atsuyoshi

    2005-04-01

    A drumlike traditional Japanese instrument, the mokugyo, is experimentally discussed. First, the acoustic characteristics of 176 mokugyos with diameters ranging from 7.5 to 120 cm and three drumsticks were measured. Results show that (a) the sound spectra consist of two common peaks [F1 (Hz): first peak frequency, F2 (Hz): second peak frequency] close together, with an average ratio (F2/F1) of 1.15, and (b) a drumstick beating the mokugyo is translated into an impact force applied over a period of time from 1 to 6 ms related to the mass and stiffness of the material wrapped around the tip of the drumstick. Second, to evaluate the acoustic response of a mokugyo in the final tuning process, the mechanical and acoustical analogy between the mokugyo and a bass reflex loudspeaker is theoretically and experimentally discussed. Results show that the model can be estimated within a relative error of 0.52% from the mass of wood chips. Finally, from a psychological experiment, the timbre of the mokugyo shows higher scores on psychological scales when the ratio (F2/F1) becomes 1.15. .

  20. Common Terms

    Science.gov (United States)

    ... Print Page Text Size: A A A Listen Common Terms Below is a list of diabetes-related ... a skin condition characterized by darkened skin patches; common in people whose body is not responding correctly ...

  1. Dynamic field of elastic displacements in a rope which is reeled up on the drum at lifting of loads

    Directory of Open Access Journals (Sweden)

    V. A. Ostapenko

    2011-11-01

    Full Text Available The boundary-value problem about construction of the displacement waves and the strain waves arising in ropes of elevating devices, such as lifts, mine lifts and so on is considered. The rope at lifting of loads is reeled up on a drum. In a case when the friction coefficient of a rope about a drum is not too big, occurs frictional sliding a rope on a drum. Therefore the behavior of a rope on a drum is described by the telegraph equation. The behavior of a hanging part of a rope is described by the wave equation. It means, that in different parts of a rope the displacements are solutions of the different equations. That is from this point of view the rope is shared on two zones. Thus owing to reeling of a rope on a drum the border which shares these two zones is a variable. In such model the waves not only reflect from ending points of a rope. There is also their reflection and refraction on moving border of the sharing of zones. Is developed methods for obtaining of exact solutions for the boundary-value problems with mobile borders for both the wave and telegraph equations. They are based on maintenance of a continuity of the displacements in points of reflection of waves. The exact solution of such problem is obtained for the case of sagging a rope prior to the beginning of rise.

  2. Habitat-related predation on juvenile wild-caught and hatchery-reared red drum Sciaenops ocellatus (Linnaeus).

    Science.gov (United States)

    Stunz, G W.; Minello, T J.

    2001-05-31

    We examined the patterns of habitat-specific mortality for newly settled red drum (Sciaenops ocellatus) using an experimental mesocosm approach. Experiments were designed to analyze prey vulnerability and fish rearing-type (wild-caught or hatchery-reared) in estuarine habitats of varying structural complexity including marsh (Spartina alterniflora Loisel), oyster reef (Crassostrea virginica Gmelin), seagrass (Halodule wrightii Aschers), and nonvegetated sand bottom. We used two different predators, pinfish (Lagodon rhomboides Linnaeus) and spotted seatrout (Cynoscion nebulosus Cuvier). For both predators, vulnerability of wild-caught red drum was significantly lower in structurally complex habitats such as seagrass and oyster reef; the highest vulnerability was associated with the nonvegetated bottom. This habitat effect was not apparent for hatchery-reared prey. In trials using a combination of both rearing-types, there was no significant habitat effect on prey selection, but hatchery-reared red drum suffered higher overall mortality than wild-caught fish from pinfish predators. In these trials, spotted seatrout did not select for either prey type. Differences we observed in prey vulnerability were likely caused by behavioral differences between wild-caught and hatchery-reared red drum. Our results reinforce the conclusion that structural complexity in estuarine habitats increases survival of newly settled fishes. Our data also suggest that hatchery-reared red drum may be more vulnerable to predation than natural fishes, and that survival of stocked fish may be enhanced through habitat-related behavior modification.

  3. Common Cold

    Science.gov (United States)

    ... nose, coughing - everyone knows the symptoms of the common cold. It is probably the most common illness. In the course of a year, people ... avoid colds. There is no cure for the common cold. For relief, try Getting plenty of rest ...

  4. Fielded ATM network for the Air National Guard Global Yankee Fort Drum exercise

    Science.gov (United States)

    Kaminski, Robert L.; Hague, Daniel; Maciag, Chester

    1996-06-01

    This paper will review the deployment, demonstration, and test of an Asynchronous Transfer Mode (ATM) network to support the Air National Guard `Global Yankee' field exercise held at Fort Drum, New York. The network provided forty five (45) megabit per second (mbps) ATM connections between the Air Operations Center (AOC) and Forward Operating Location (FOL) located at Fort Drum, the State University of New York (SUNY) Health Science Center located in Syracuse, New York and Rome Laboratory located in Rome, New York. Connections were made with both fiber and free space equipment. The fiber connections used were part of the existing ATM New York Network (NYNet) between Rome Lab, SUNY Health Science Center and NYNEX Corporation. This network was extended to Watertown, New York by NYNEX to provide connectivity to Fort Drum. The free space links were provided by commercial DS-3 (45 mbps) radios, and 2 to 6 mbps Troposcatter Satellite Support Radios (TSSRs). This paper will also discuss significant digital Command, Control, Communications and Intelligence enhancements to the battlefield provided by the deployed ATM network. For example, videoconferencing and shared workspace capability was demonstrated over the AOC-to-FOL TSSR link, enabling remote intelligence briefings, pilot Battle Damage Assessment, and Search and Rescue coordination. Remote Medical Diagnostics videoconferencing with MRI high resolution digital imagery was demonstrated between the FOL, AOC, and SUNY Health Science Center. Finally, the network provided connectivity between the AOC and the Joint Surveillance System (JSS) radar's located at Griffiss Air Force BAse. The JSS data combined with the Rome Lab developed Radar Analysis Program provided AOC personnel with air picture areas of interest.

  5. The Impact of Group Drumming on Social-Emotional Behavior in Low-Income Children

    Directory of Open Access Journals (Sweden)

    Ping Ho

    2011-01-01

    Full Text Available Low-income youth experience social-emotional problems linked to chronic stress that are exacerbated by lack of access to care. Drumming is a non-verbal, universal activity that builds upon a collectivistic aspect of diverse cultures and does not bear the stigma of therapy. A pretest-post-test non-equivalent control group design was used to assess the effects of 12 weeks of school counselor-led drumming on social-emotional behavior in two fifth-grade intervention classrooms versus two standard education control classrooms. The weekly intervention integrated rhythmic and group counseling activities to build skills, such as emotion management, focus and listening. The Teacher’s Report Form was used to assess each of 101 participants (n = 54 experimental, n = 47 control, 90% Latino, 53.5% female, mean age 10.5 years, range 10–12 years. There was 100% retention. ANOVA testing showed that intervention classrooms improved significantly compared to the control group in broad-band scales (total problems (P < .01, internalizing problems (P < .02, narrow-band syndrome scales (withdrawn/depression (P < .02, attention problems (P < .01, inattention subscale (P < .001, Diagnostic and Statistical Manual of Mental Disorders-oriented scales (anxiety problems (P < .01, attention deficit/hyperactivity problems (P < .01, inattention subscale (P < .001, oppositional defiant problems (P < .03, and other scales (post-traumatic stress problems (P < .01, sluggish cognitive tempo (P < .001. Participation in group drumming led to significant improvements in multiple domains of social-emotional behavior. This sustainable intervention can foster positive youth development and increase student-counselor interaction. These findings underscore the potential value of the arts as a therapeutic tool.

  6. Pengaruh kecepatan drum proses terhadap sifat fisik kulit kambing untuk sarung tangan golf

    Directory of Open Access Journals (Sweden)

    Sugeng Supriadi

    1998-06-01

    Full Text Available Fifteen pieces of wet blue were devided into three groups of equal number of pieces. All of the group were processed into glove leather with drum rotational speed of 15 RPM and 25 RPM resfectively. Analysis of varians showed that the speed effected the tensile strength, tensile stretch, elongation, and tear strength of the leather obtained. The leather processed at 25 RPM gave the highest tensile strength (138,56 kg/cm2 tensile stretch (29,30 mm, elongation (58,60%, and tear strength (30,53 kh/cm.

  7. Euler-like modelling of dense granular flows: application to a rotating drum

    Science.gov (United States)

    Bonamy, D.; Chavanis, P.-H.; Cortet, P.-P.; Daviaud, F.; Dubrulle, B.; Renouf, M.

    2009-04-01

    General conservation equations are derived for 2D dense granular flows from the Euler equation within the Boussinesq approximation. In steady flows, the 2D fields of granular temperature, vorticity and stream function are shown to be encoded in two scalar functions only. We checked such prediction on steady surface flows in a rotating drum simulated through the Non-Smooth Contact Dynamics method even though granular flows are dissipative and therefore not necessarily compatible with Euler equation. Finally, we briefly discuss some possible ways to predict theoretically these two functions using statistical mechanics.

  8. Electrically integrated SU-8 clamped graphene drum resonators for strain engineering

    Science.gov (United States)

    Lee, Sunwoo; Chen, Changyao; Deshpande, Vikram V.; Lee, Gwan-Hyoung; Lee, Ilkyu; Lekas, Michael; Gondarenko, Alexander; Yu, Young-Jun; Shepard, Kenneth; Kim, Philip; Hone, James

    2013-04-01

    Graphene mechanical resonators are the ultimate two-dimensional nanoelectromechanical systems (NEMS) with applications in sensing and signal processing. While initial devices have shown promising results, an ideal graphene NEMS resonator should be strain engineered, clamped at the edge without trapping gas underneath, and electrically integratable. In this Letter, we demonstrate fabrication and direct electrical measurement of circular SU-8 polymer-clamped chemical vapor deposition graphene drum resonators. The clamping increases device yield and responsivity, while providing a cleaner resonance spectrum from eliminated edge modes. Furthermore, the clamping induces a large strain in the resonator, increasing its resonant frequency.

  9. An optimization of inner structures of the drying chamber of high temperature pneumatic drum drier

    Directory of Open Access Journals (Sweden)

    Topić Radivoje M.

    2010-01-01

    Full Text Available In this paper an analysis of the influence of parameters of flights from inner drying chamber structure and drying chamber is given. The influence of the following parameters on dryer working process is analyzed: number, shape and width of flights, level of coverage of cross-section drying chamber by material, rpm and drying chamber diameter. In the analytical expression for determining the amount of material seized by a curved flight, depending on the current position of the flight during drum rotation, a new parameter is introduced, compared to expression for a rectilinear flight. The expanded analytical expression could be used for optimization.

  10. Shapes of drums with lowest base frequency under non-isotropic perimeter constraints

    OpenAIRE

    Biskup, Marek; Procaccia, Eviatar B.

    2016-01-01

    We study the minimizers of the sum of the principal Dirichlet eigenvalue of the negative Laplacian and the perimeter with respect to a general norm in the class of Jordan domains in the plane. This is equivalent (modulo scaling) to minimizing the said eigenvalue (or the base frequency of a drum of this shape) subject to a hard constraint on the perimeter. We show that, for all norms, a minimizer exists, is unique up to spatial translations and is convex but not necessarily smooth. We give con...

  11. Geophysical logging at the Cristex Drum National Priorities List Superfund Site near Oxford, North Carolina

    Science.gov (United States)

    Antolino, Dominick J.

    2017-01-01

    The collection of borehole geophysical logs data was conducted by the U.S. Geological Survey South Atlantic Water Science Center in the vicinity of the Cristex Drum National Priorities List Superfund Site near Oxford, North Carolina, during January through March 2016. In an effort to assist the U.S. Environmental Protection Agency in the development of a conceptual groundwater model for the assessment of current contaminant distribution and future migration of contaminants, borehole geophysical log and image data collection, which included the delineation of more than 150 subsurface features (primarily fracture orientations) in 3 open borehole wells.

  12. Method for Detecting the Inside of Coke Drum Using Acoustic Signals

    Directory of Open Access Journals (Sweden)

    Qian Guo

    2017-01-01

    Full Text Available A distance and acoustic intensity reverberation (DAIR physical model is developed that can be successfully applied to the signal processing of the hydraulic decoking process online monitoring. In this model, the transmission characteristics of acoustic signals generated by a moving sound source in a dynamic confined space are first analyzed using data recursion and correction according to the coordinate continuity in adjacent area and adjacent time. The results show that the nondetection zone of acoustic signals generated directly by the impact of water is eliminated, and the surface distribution of coke in the drum can be mapped in real time.

  13. New construction of an in-drum drying plant in the central decontamination and water treatment facility (ZDW)

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, Martin; Koischwitz, Ingmar; Viermann, Jorg [GNS Gesellschaft fur Nuklear-Service mbh, Essen (Germany)

    2013-07-01

    In order to ensure future conditioning of the accumulating radioactive liquid waste during the advancing dismantling of the nuclear power plant Greifswald, GNS provides EWN within the new construction of the ZDW with an in-drum drying plant, including the appropriate infrastructure and media supply. For the in-drum drying plant, GNS has consistently further developed the process of the FAVORIT plant operationally proven for many years. Noteworthy is that for the first time a fully automatic plant of this type has been implemented which requires interventions of the operating personnel only for rounds and for loading and unloading processes of the drum stations. Moreover, components of the vacuum unit were designed according to needs and optimised with regard to installation space and plant engineering. (authors)

  14. Feasibility study of 235U and 239Pu characterization in radioactive waste drums using neutron-induced fission delayed gamma rays

    Science.gov (United States)

    Nicol, T.; Pérot, B.; Carasco, C.; Brackx, E.; Mariani, A.; Passard, C.; Mauerhofer, E.; Collot, J.

    2016-10-01

    This paper reports a feasibility study of 235U and 239Pu characterization in 225 L bituminized waste drums or 200 L concrete waste drums, by detecting delayed fission gamma rays between the pulses of a deuterium-tritium neutron generator. The delayed gamma yields were first measured with bare samples of 235U and 239Pu in REGAIN, a facility dedicated to the assay of 118 L waste drums by Prompt Gamma Neutron Activation Analysis (PGNAA) at CEA Cadarache, France. Detectability in the waste drums is then assessed using the MCNPX model of MEDINA (Multi Element Detection based on Instrumental Neutron Activation), another PGNAA cell dedicated to 200 L drums at FZJ, Germany. For the bituminized waste drum, performances are severely hampered by the high gamma background due to 137Cs, which requires the use of collimator and shield to avoid electronics saturation, these elements being very penalizing for the detection of the weak delayed gamma signal. However, for lower activity concrete drums, detection limits range from 10 to 290 g of 235U or 239Pu, depending on the delayed gamma rays of interest. These detection limits have been determined by using MCNPX to calculate the delayed gamma useful signal, and by measuring the experimental gamma background in MEDINA with a 200 L concrete drum mock-up. The performances could be significantly improved by using a higher interrogating neutron emission and an optimized experimental setup, which would allow characterizing nuclear materials in a wide range of low and medium activity waste packages.

  15. Intelligent Mobile Sensor System for drum inspection and monitoring -- Volume 1. Final report, October 1, 1993--April 22, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The objective of the Intelligent Mobile Sensor System (IMSS) project is to develop an operational system for monitoring and inspection activities for waste storage facility operations at several DOE sites. Specifically, the product of this effort is a robotic device with enhanced intelligence and maneuverability capable of conducting routine inspection of stored waste drums. The device is capable of operating in the narrow free aisle space between rows of stacked drums. The system has an integrated sensor suite for problem-drum detection, and is linked to a site database both for inspection planning and for data correlation, updating, and report generation. The system is capable of departing on an assigned mission, collecting required data, recording which portions of its mission had to be aborted or modified due to environmental constraints, and reporting back when the mission is complete. Successful identification of more than 96% of drum defects has been demonstrated in a high fidelity waste storage facility mockup. Identified anomalies included rust spots, rust streaks, areas of corrosion, dents, and tilted drums. All drums were positively identified and correlated with the site database. This development effort is separated into three phases of which phase two is now complete. The first phase demonstrated an integrated system (maturity level IVa) for monitoring and inspection activities for waste storage facility operations. The second phase demonstrated a prototype system appropriate for operational use in an actual storage facility. The prototype provides an integrated design that considers operational requirements, hardware costs, maintenance, safety, and robustness. The final phase will demonstrate commercial viability using the prototype vehicle in a pilot waste operations and inspection project. This report summarizes the design and evaluation of the new IMSS Phase 2 system and vehicle.

  16. Application of artificial neural networks on the characterization of radioactive waste drums; Aplicacao de redes neurais artificiais na caracterizacao de tambores de rejeito radioativo

    Energy Technology Data Exchange (ETDEWEB)

    Potiens Junior, Ademar Jose; Hiromoto, Goro, E-mail: apotiens@ipen.b, E-mail: hiromoto@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-10-26

    The methodology consist of system simulation of drum-detector by Monte Carlo for obtention of counting efficiency. The obtained data were treated and a neural artificial network (RNA) were constructed for evaluation of total activity of drum. For method evaluation measurements were performed in ten position parallel to the drum axis and the results submitted to the RNA. The developed methodology showed to be effective for isotopic characterization of gamma emitter radioactive wastes distributed in a heterogeneous way in a 200 litters drum. The objective of this work as to develop a methodology of analyse for quantification and localization of radionuclides not homogeneous distributed in a 200 liters drum based on the mathematical techniques

  17. Student Commons

    Science.gov (United States)

    Gordon, Douglas

    2010-01-01

    Student commons are no longer simply congregation spaces for students with time on their hands. They are integral to providing a welcoming environment and effective learning space for students. Many student commons have been transformed into spaces for socialization, an environment for alternative teaching methods, a forum for large group meetings…

  18. Portrayals of men and women in Drum magazine (South Africa advertisements

    Directory of Open Access Journals (Sweden)

    Mlenga Jere

    2014-02-01

    Full Text Available Orientation: The subject of gender portrayals in advertising continues to generate academicdiscussions in part because of its socialisation effects.Research purpose: The purpose of this study is to determine how print advertisements inDrum magazine portray women and men based on a number of categories including traitdescriptors, physical characteristics, role behaviours and occupational status.Motivation for the study: It is important to understand gender portrayals in advertisingbecause perceptions of social reality are influenced by what people are exposed to insocialisation agents such as advertisements.Research approach, design and method: A quantitative content analysis was run on a sampleof 415 advertisements drawn from Drum magazine. Partial least squares analysis was used toassess the relationships between the variables.Main findings: The findings show that gender has a statistically significant effect on profiles(roles and sexual appeal but not on gender equity. Advertisers therefore treat modelsdifferently with regard to the roles assigned and the use of sexual appeal.Practical/managerial implications: Previous research evidence and theory indicate that thecontent of advertisements does influence readers’ self-perception and also their perceptionof others. Within the bounds of advertising creativity, it is important that advertisers payparticular attention to gender portrayals in advertising to avoid the creation or perpetuationof gender stereotypes.Contribution/value-add: Though the model’s gender influences portrayals in advertising,other contextual factors are also important determinants of portrayals.

  19. Magnetic anomalies of steel drums: a review of the literature and research results of the INGV

    Directory of Open Access Journals (Sweden)

    Marco Marchetti

    2013-04-01

    Full Text Available The detection and evaluation of the status of disposal sites that contain hazardous waste materials is becoming an increasingly important element in environmental investigations. Close cooperation between the Istituto Nazionale di Geofisica e Vulcanologia (INGV; National Institute of Volcanology and Geophysics in Rome and the Italian environmental police has resulted in numerous underground investigations of different buried materials. Among the geophysical investigation tools, magnetometry is the most effective, rapid and precise of all of the geophysical methods for localizing buried steel drums. Analysis of magnetic map anomalies can provide a variety of information about buried materials, including extension, distribution and depth, with processing of the acquired magnetic data. This information is also very useful in case of excavations that are aimed at the recovery of hazardous waste. This study determines the most relevant analyses reported in the literature, with modeling of magnetometric methods for environmental applications both theoretically and experimentally. Some studies and research results achieved by the INGV in relation to magnetic anomalies produced by buried steel drums are also reported, as found in field operations and as achieved from test sites.

  20. "Are you going to be Miss (or Mr) Africa?" Contesting masculinity in Drum magazine.

    Science.gov (United States)

    Clowes, L

    2001-01-01

    Drum magazine was first published in March 1951. Like other magazines, it both reflected and shaped the society from which its audience emerged. During 1951, its audience, mainly urban black readers, was able to push the publication away from its original rural focus towards an urban emphasis. Town living, however, meant different things to different people. Thus, while readers were successful in shifting the focus of the magazine, they were less successful in influencing the way the publication presented urban life. This paper explores the struggle between readers, journalists and editors over the Miss Africa beauty contest announced at the beginning of 1952. Although the magazine reluctantly admitted men to the contest, it discriminated against male entrants in a variety of ways over the course of the year, and subsequent competitions barred male contestants entirely. Despite opposition from male readers who wished to be considered beautiful, the men of Drum were largely successful in asserting their own deeply gendered cultural vision of urban life.

  1. Fault Diagnosis of Demountable Disk-Drum Aero-Engine Rotor Using Customized Multiwavelet Method

    Directory of Open Access Journals (Sweden)

    Jinglong Chen

    2015-10-01

    Full Text Available The demountable disk-drum aero-engine rotor is an important piece of equipment that greatly impacts the safe operation of aircraft. However, assembly looseness or crack fault has led to several unscheduled breakdowns and serious accidents. Thus, condition monitoring and fault diagnosis technique are required for identifying abnormal conditions. Customized ensemble multiwavelet method for aero-engine rotor condition identification, using measured vibration data, is developed in this paper. First, customized multiwavelet basis function with strong adaptivity is constructed via symmetric multiwavelet lifting scheme. Then vibration signal is processed by customized ensemble multiwavelet transform. Next, normalized information entropy of multiwavelet decomposition coefficients is computed to directly reflect and evaluate the condition. The proposed approach is first applied to fault detection of an experimental aero-engine rotor. Finally, the proposed approach is used in an engineering application, where it successfully identified the crack fault of a demountable disk-drum aero-engine rotor. The results show that the proposed method possesses excellent performance in fault detection of aero-engine rotor. Moreover, the robustness of the multiwavelet method against noise is also tested and verified by simulation and field experiments.

  2. IMPROVING THERMAL PERFORMANCE OF RADIOACTIVE MATERIAL DRUM TYPEPACKAGES BY USING HEAT PIPES

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, N

    2007-03-06

    This paper presents a feasibility study to improve thermal loading of existing radioactive material packages by using heat pipes. The concept could be used to channel heat in certain directions and dissipate to the environment. The concept is applied to a drum type package because the drum type packages are stored and transported in an upright position. This orientation is suitable for heat pipe operation that could facilitate the heat pipe implementation in the existing well proven package designs or in new designs where thermal loading is high. In this position, heat pipes utilize gravity very effectively to enhance heat flow in the upward direction Heat pipes have extremely high effective thermal conductivity that is several magnitudes higher than the most heat conducting metals. In addition, heat pipes are highly unidirectional so that the effective conductivity for heat transfer in the reverse direction is greatly reduced. The concept is applied to the 9977 package that is currently going through the DOE certification review. The paper presents computer simulations using typical off-the-shelf heat pipe available configurations and performance data for the 9977 package. A path forward is outlined for implementing the concepts for further study and prototype testing.

  3. Analytical Chemistry and Materials Characterization Results for Debris Recovered from Nitrate Salt Waste Drum S855793

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, Patrick Thomas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Chamberlin, Rebecca M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Schwartz, Daniel S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worley, Christopher Gordon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Garduno, Katherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lujan, Elmer J. W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Borrego, Andres Patricio [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Castro, Alonso [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Colletti, Lisa Michelle [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fulwyler, James Brent [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Holland, Charlotte S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Keller, Russell C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Klundt, Dylan James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinez, Alexander [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martin, Frances Louise [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montoya, Dennis Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Myers, Steven Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Porterfield, Donivan R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Schake, Ann Rene [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Schappert, Michael Francis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Soderberg, Constance B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Spencer, Khalil J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stanley, Floyd E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Thomas, Mariam R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Townsend, Lisa Ellen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Xu, Ning [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-16

    Solid debris was recovered from the previously-emptied nitrate salt waste drum S855793. The bulk sample was nondestructively assayed for radionuclides in its as-received condition. Three monoliths were selected for further characterization. Two of the monoliths, designated Specimen 1 and 3, consisted primarily of sodium nitrate and lead nitrate, with smaller amounts of lead nitrate oxalate and lead oxide by powder x-ray diffraction. The third monolith, Specimen 2, had a complex composition; lead carbonate was identified as the predominant component, and smaller amounts of nitrate, nitrite and carbonate salts of lead, magnesium and sodium were also identified. Microfocused x-ray fluorescence (MXRF) mapping showed that lead was ubiquitous throughout the cross-sections of Specimens 1 and 2, while heteroelements such as potassium, calcium, chromium, iron, and nickel were found in localized deposits. MXRF examination and destructive analysis of fragments of Specimen 3 showed elevated concentrations of iron, which were broadly distributed through the sample. With the exception of its high iron content and low carbon content, the chemical composition of Specimen 3 was within the ranges of values previously observed in four other nitrate salt samples recovered from emptied waste drums.

  4. 鼓式取皮机的切取技巧在瘢痕松解植皮中应用%The technology of Drum Type Skin Taking Machine Drum applied in the scar tissues resecting and skin grafting

    Institute of Scientific and Technical Information of China (English)

    曾光伟; 李玉梅; 何俊俊; 杨明勇

    2013-01-01

    目的:鼓式取皮机的应用技巧在临床应用.方法:40例患者存在颌颈或腘窝瘢痕增生挛缩畸形并切除松解,鼓式取皮机切取的中厚皮片移植矫正.结果:鼓式取皮机的应用技巧能够获取精确中厚皮片且移植成活良好.结论:鼓式取皮机的应用技巧实施,能够提供精确的中厚皮片;皮片移植的临床治疗效果良好.%Objective The application techniques of Drum Type Skin Taking Machine in acquisition the appropriate thick skin grafting in clinical applications.Methods 40 cases of patients with scar proliferation of jaw or neck with scar excision and relax,Drum Type Skin Taking Machine take the appropriate thick skin in correction with skin grafting.Results The application techniques of Drum Type Skin Taking Machine can obtain the accurate appropriate thick skin,the skin survived well after grafting.Conclusion Drum Type Skin Taking Machine can provide the accurate appropriate thick skin in the skin grafting with good clinical outcomes.

  5. Common Courses for Common Purposes:

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    2014-01-01

    (PME)? I suggest three alternative paths that increased cooperation in PME at the level of the command and staff course could take: a Nordic Defence College, standardized national command and staff courses, and a core curriculum of common courses for common purposes. I conclude with a discussion of how...

  6. Common Courses for Common Purposes:

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    2014-01-01

    (PME)? I suggest three alternative paths that increased cooperation in PME at the level of the command and staff course could take: a Nordic Defence College, standardized national command and staff courses, and a core curriculum of common courses for common purposes. I conclude with a discussion of how...

  7. QCI Common

    Energy Technology Data Exchange (ETDEWEB)

    2016-11-18

    There are many common software patterns and utilities for the ORNL Quantum Computing Institute that can and should be shared across projects. Otherwise we find duplication of code which adds unwanted complexity. This is a software product seeks to alleviate this by providing common utilities such as object factories, graph data structures, parameter input mechanisms, etc., for other software products within the ORNL Quantum Computing Institute. This work enables pure basic research, has no export controlled utilities, and has no real commercial value.

  8. Synchronized drumming enhances activity in the caudate and facilitates prosocial commitment--if the rhythm comes easily

    NARCIS (Netherlands)

    Kokal, Idil; Engel, Annerose; Kirschner, Sebastian; Keysers, Christian

    2011-01-01

    Why does chanting, drumming or dancing together make people feel united? Here we investigate the neural mechanisms underlying interpersonal synchrony and its subsequent effects on prosocial behavior among synchronized individuals. We hypothesized that areas of the brain associated with the processin

  9. Fluctuations of hi-hat timing and dynamics in a virtuoso drum track of a popular music recording.

    Directory of Open Access Journals (Sweden)

    Esa Räsänen

    Full Text Available Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro's one-handed hi-hat pattern in "I Keep Forgettin'"-one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro's drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy.

  10. Effects of cooling rate on vermicular graphite percentage in a brake drum produced by one-step cored wire injection

    Directory of Open Access Journals (Sweden)

    Yu-shuang Feng

    2015-09-01

    Full Text Available In this research, a vermicular graphite cast iron brake drum was produced by cored wire injection in a one-step method. Silica sand and low-density alumina-silicate ceramic were used as molding materials in order to investigate the effect of cooling rate on percentage of vermicular graphite and mechanical properties of the brake drum casting. Several thermocouples were inserted into the casting in the desired positions to measure the temperature change. By means of one-step cored wire injection, the two residual concentrations of Mg and RE were effectively controlled in the ranges of 0.013%-0.017% and 0.019%-0.025%, respectively, which are crucial for the production of vermicular graphite cast iron and the formation of vermicular graphite. In addition, the cooling rate had a significant effect on the vermicular graphite percentage. In the case of the silica mold brake drum casting, there was an obvious difference in the cooling rate with the wall change, leading to a change in vermicular graphite percentage from 70.8% to 90%. In the low-density alumina-silicate ceramic mold casting, no obvious change in temperature was detected by the thermocouples and the percentage of the vermicular graphite was stable at 85%. Therefore, the vermicular graphite cast iron brake drum with a better combination of mechanical properties could be obtained.

  11. First Industrial Tests of a Matrix Monitor Correction for the Differential Die-away Technique of Historical Waste Drums

    Energy Technology Data Exchange (ETDEWEB)

    Antoni, Rodolphe; Passard, Christian; Perot, Bertrand [CEA Cadarache DEN/Nuclear Measurement Laboratory, 13108 Saint-Paul lez Durance (France); Batifol, Marc; Vandamme, Jean-Christophe [Nuclear Measurement Team, AREVA NC, La Hague plant F-50444 Beaumont-Hague (France); Grassi, Gabriele [AREVA NC, 1 place Jean-Millier, 92084 Paris-La-Defense cedex (France)

    2015-07-01

    The fissile mass in radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA NC La Hague reprocessing plant is measured by neutron interrogation with the Differential Die-away measurement Technique (DDT). In the next years, old hulls and nozzles mixed with Ion-Exchange Resins will be measured. The ion-exchange resins increase neutron moderation in the matrix, compared to the waste measured in the current process. In this context, the Nuclear Measurement Laboratory (LMN) of CEA Cadarache has studied a matrix effect correction method, based on a drum monitor, namely a 3He proportional counter located inside the measurement cavity. After feasibility studies performed with LMN's PROMETHEE 6 laboratory measurement cell and with MCNPX simulations, this paper presents first experimental tests performed on the industrial ACC (hulls and nozzles compaction facility) measurement system. A calculation vs. experiment benchmark has been carried out by performing dedicated calibration measurements with a representative drum and {sup 235}U samples. The comparison between calculation and experiment shows a satisfactory agreement for the drum monitor. The final objective of this work is to confirm the reliability of the modeling approach and the industrial feasibility of the method, which will be implemented on the industrial station for the measurement of historical wastes. (authors)

  12. Modification of whole flours of navy bean, pinto bean, black bean and chickpea by steam jet cooking and drum drying

    Science.gov (United States)

    Whole bean flours of navy bean, pinto bean, black bean and chickpea were processed by excess steam jet cooking, drum drying, and milling to a state resembling the raw flours. Analysis of the structure and size of the particles, color, solubility and pasting characteristics, dietary fiber, and protei...

  13. Effects of the prebiotics GroBiotic-A and inulin on the intestinal microbiota of red drum, Sciaenops ocellatus

    Science.gov (United States)

    Two separate feeding trials examined the effects of dietary supplementation of the prebiotics GroBiotic®-A and inulin on growth performance and gastrointestinal tract microbiota of the red drum Sciaenops ocellatus. In the first feeding trial, fishmeal-based diets without prebiotics or supplemented ...

  14. Large-Scale Fusion of Gray Matter and Resting-State Functional MRI Reveals Common and Distinct Biological Markers across the Psychosis Spectrum in the B-SNIP Cohort.

    Science.gov (United States)

    Wang, Zheng; Meda, Shashwath A; Keshavan, Matcheri S; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A; Schretlen, David J; Calhoun, Vince D; Lui, Su; Pearlson, Godfrey D

    2015-01-01

    To investigate whether aberrant interactions between brain structure and function present similarly or differently across probands with psychotic illnesses [schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar I disorder with psychosis (BP)] and whether these deficits are shared with their first-degree non-psychotic relatives. A total of 1199 subjects were assessed, including 220 SZ, 147 SAD, 180 psychotic BP, 150 first-degree relatives of SZ, 126 SAD relatives, 134 BP relatives, and 242 healthy controls (1). All subjects underwent structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) scanning. Joint-independent component analysis (jICA) was used to fuse sMRI gray matter and rs-fMRI amplitude of low-frequency fluctuations data to identify the relationship between the two modalities. jICA revealed two significantly fused components. The association between functional brain alteration in a prefrontal-striatal-thalamic-cerebellar network and structural abnormalities in the default mode network was found to be common across psychotic diagnoses and correlated with cognitive function, social function, and schizo-bipolar scale scores. The fused alteration in the temporal lobe was unique to SZ and SAD. The above effects were not seen in any relative group (including those with cluster-A personality). Using a multivariate-fused approach involving two widely used imaging markers, we demonstrate both shared and distinct biological traits across the psychosis spectrum. Furthermore, our results suggest that the above traits are psychosis biomarkers rather than endophenotypes.

  15. Comparative structural biology of the genome: nano-scale imaging of single nucleus from different kingdoms reveals the common physicochemical property of chromatin with a 40 nm structural unit.

    Science.gov (United States)

    Kobori, Toshiro; Kodama, Mami; Hizume, Kohji; Yoshimura, Shige H; Ohtani, Toshio; Takeyasu, Kunio

    2006-01-01

    Genome function is closely linked to the higher-order chromatin structures. To reveal a structural basis for the interphase chromatin organization, the 'on-substrate' lysis procedure was applied to nuclei isolated from human HeLa cells, chicken erythrocyte cells and yeast Schizosaccharomyces pombe, which possessed different intrinsic properties of the genomes such as histone composition and inter-nucleosomal distance. The isolated nuclei on a coverslip were successively treated with a detergent and a high-salt solution to extract the nuclear membrane and the nucleoplasm, and therefore, atomic force microscopy (AFM) visualized the structural changes in response to the lysis procedure. After the nucleoplasm was extracted, AFM clarified that chromatin fibers, approximately 40 nm in width, were partially released out of the nuclei and that the other chromatin still remaining in the nuclei was composed of granular structures with diameter of 80-100 nm. Thus, these results suggest that the approximately 40 nm fiber would be a stable structural unit and fold the 80-100 nm granules into a one-step higher unit. A common mechanism could be implied regardless of the intrinsic properties of the eukaryotic genomes.

  16. SINTESIS NANOSERAT POLI(VINIL ALKOHOL DALAM BENTUK LEMBARAN DENGAN PEMINTAL ELEKTRIK MULTI NOZEL DAN KOLEKTOR DRUM

    Directory of Open Access Journals (Sweden)

    A. Y. Nuryantini

    2014-07-01

    Full Text Available Sistem pemintalan elektrik jarum tunggal dan kolektor bidang memiliki kelemahan, yaitu laju produksi yang rendah. Untuk mengatasinya digunakan sistem jarum banyak yang berjejer (multi nozel dan kolektor berbentuk silinder berputar (kolektor drum. Banyaknya jarum dimaksudkan untuk menambah laju produksi, kolektor drum berputar dimaksudkan agar dihasilkan nanoserat dalam bentuk lembaran yang seragam. Tujuan penelitian adalah untuk menguji pengaruh medan listrik pada proses pemintalan elektrik multi nozel dan kolektor drum berputar, serta mengontrol morfologi nanoserat poli(vinil alkohol/PVA yang dihasilkan dengan cara mengubah laju alir larutan. Hasil penelitian yang didapat adalah: (1 telah berhasil dibuat nanoserat PVA dalam bentuk lembaran yang menumpuk di kolektor drum, (2 pada pemintalan elektrik dengan sistem multi nozel terjadi distorsi medan listrik pada ujung jarum yang menyebabkan serat pada kolektor tidak rata, (3 morfologi nanoserat PVA yang dihasilkan pada laju alir 0,4 dan 0,6 ml/jam banyak mengandung butiran, sedangkan pada laju alir 0,8 ml/jam jumlah butiran berkurang.ABSTRACTElectrospinning system with single needle and planar collector has the disadvantage of a low productivity. To overcome this problem drum collector and multi-nozzle system were employed. The multi-nozzle system was used to improve the production rate, while the drum collector was used for maintaining the uniformity of the size. The purposes of this study were to examine the influence of electric field in the electrospinning process and to control the morphology of the obtained poly(vinyl alcohol/PVA nanofibers by changing the solution flow rate. The obtained results were: (1 PVA nanofibers membrane have been successfully produced stacked on the drum collector, (2 distortion of the electric field at the tip of the needle was occurred, which results in inhomogeneous thickness of the stacked nanofibers, and (3 the morphology of the obtained nanofibers at the flow

  17. Instituting Commoning

    Directory of Open Access Journals (Sweden)

    . STEALTH.unlimited

    2015-06-01

    Full Text Available Starting from the origins of the notion of management, this paper explores how commons governance is constituted by the earlier influential research of Elinor Ostrom, and pursues this with reference to scholars such as Saki Bailey, who emphasises that the choice of regulatory frame is ultimately a political one. We then argue that commons have to be ‘instituted’ in an open manner in order to remain accessible. This demands a set of scripts, rules or agreements that keep the process of commoning in place, and, simultaneously, keep commoning in a constant process of reproduction. We examine this tension and look at the shift in understanding about what ‘institutions of the commons’ have entailed in practice over the course of the last century and a half. Finally, we return to the political dimension to touch upon the question of whether, with the disappearance of the welfare state, a coherent concept of society can emerge from the current upsurge of commons initiatives.

  18. The Effect of Different Phases of Synchrony on Pain Threshold in a Drumming Task

    Directory of Open Access Journals (Sweden)

    Philip Sullivan

    2017-06-01

    Full Text Available Behavioral synchrony has been linked to endorphin activity (Cohen et al., 2010; Sullivan and Rickers, 2013; Sullivan et al., 2014; Tarr et al., 2015, 2016; Weinstein et al., 2016. This has been called the synchrony effect. Synchrony has two dominant phases of movement; in-phase and anti-phase. The majority of research investigating synchrony’s effect on endorphin activity has focused on in-phase synchrony following vigorous activities. The only research to investigate the effects of anti-phase synchrony on endorphin activity found that anti-phase synchronized rowing did not produce the synchrony effect (Sullivan et al., 2014. Anti-phase synchrony, however, is counter-intuitive to the sport of rowing and may have interfered with the synchrony effect. This study investigated the effect of anti-phase synchrony on endorphin activity in a different task (i.e., drumming. University students (n = 30 were asked to drum solo and in in-phase and anti-phase pairs for 3 min. Pain threshold was assessed as an indirect indicator of endorphin activity prior to and following the task. Although the in-phase synchrony effect was not found, a repeated measures ANOVA found that there was a significant difference in pain threshold change among the three conditions [F(2,24 = 4.10, = 0.255, p < 0.05. Post hoc t-tests showed that the anti-phase condition had a significantly greater pain threshold change than both the solo and in-phase conditions at p < 0.05. This is the first time that anti-phase synchrony has been shown to produce the synchrony effect. Because anti-phase drumming may have required more attention between partners than in-phase synchrony, it may have affected self-other merging (Tarr et al., 2014. These results support Tarr et al.’s (2014 model that multiple mechanisms account for the effect of synchrony on pain threshold, and suggest that different characteristics of the activity may influence the synchrony effect.

  19. Creative Commons

    DEFF Research Database (Denmark)

    Jensen, Lone

    2006-01-01

    En Creative Commons licens giver en forfatter mulighed for at udbyde sit værk i en alternativ licensløsning, som befinder sig på forskellige trin på en skala mellem yderpunkterne "All rights reserved" og "No rights reserved". Derved opnås licensen "Some rights reserved"......En Creative Commons licens giver en forfatter mulighed for at udbyde sit værk i en alternativ licensløsning, som befinder sig på forskellige trin på en skala mellem yderpunkterne "All rights reserved" og "No rights reserved". Derved opnås licensen "Some rights reserved"...

  20. Science commons

    CERN Document Server

    CERN. Geneva

    2007-01-01

    SCP: Creative Commons licensing for open access publishing, Open Access Law journal-author agreements for converting journals to open access, and the Scholar's Copyright Addendum Engine for retaining rights to self-archive in meaningful formats and locations for future re-use. More than 250 science and technology journals already publish under Creative Commons licensing while 35 law journals utilize the Open Access Law agreements. The Addendum Engine is a new tool created in partnership with SPARC and U.S. universities. View John Wilbanks's biography

  1. Creative Commons

    DEFF Research Database (Denmark)

    Jensen, Lone

    2006-01-01

    En Creative Commons licens giver en forfatter mulighed for at udbyde sit værk i en alternativ licensløsning, som befinder sig på forskellige trin på en skala mellem yderpunkterne "All rights reserved" og "No rights reserved". Derved opnås licensen "Some rights reserved"......En Creative Commons licens giver en forfatter mulighed for at udbyde sit værk i en alternativ licensløsning, som befinder sig på forskellige trin på en skala mellem yderpunkterne "All rights reserved" og "No rights reserved". Derved opnås licensen "Some rights reserved"...

  2. Intelligent mobile sensor system for drum inspection and monitoring: Topical report, October 1, 1993--April 22, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The objective of the Intelligent Mobile Sensor System (IMSS) project is to develop an operational system for monitoring and inspection activities for waste storage facility operations at several DOE sites. Specifically, the product of this effort is a robotic device with enhanced intelligence and maneuverability capable of conducting routine inspection of stored waste drums. The system has an integrated sensor suite for problem-drum detection, and is linked to a site database both for inspection planning and for data correlation, updating, and report generation. The system is capable of departing on an assigned mission, collecting required data, recording which portions of its mission had to be aborted or modified due to environmental constraints, and reporting back when the mission is complete. Successful identification of more than 96% of drum defects has been demonstrated in a high fidelity waste storage facility mockup. Identified anomalies included rust spots, rust streaks, areas of corrosion, dents, and tilted drums. All drums were positively identified and correlated with the site database. This development effort is separated into three phases of which phase two is now complete. The second phase demonstrated a prototype system appropriate for operational use in an actual storage facility. The prototype provides an integrated design that considers operational requirements, hardware costs, maintenance, safety, and robustness. The final phase will demonstrate commercial viability using the prototype vehicle in a pilot waste operations and inspection project. This report summarizes the design and evaluation of the new IMSS Phase 2 system and vehicle. Several parts of the IMSS Phase 1 Topical (Final) Report, which describes the requirements, design guidelines, and detailed design of the Phase 1 IMSS vehicle, are incorporated here, with modifications to reflect the changes in the design and the new elements added during the Phase 2 work.

  3. Intelligent Mobile Sensor System for drum inspection and monitoring -- Volume 2. Final report, October 1, 1993--April 22, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The objective of the Intelligent Mobile Sensor System (IMSS) project was to develop an operational system for monitoring and inspection activities for waste storage facility operations at several DOE sites. Specifically, the product of this effort was a robotic device with enhanced intelligence and maneuverability capable of conducting routine inspection of stored waste drums. The system has an integrated sensor suite for problem-drum detection, and creates and maintains a site database both for inspection planning and for data correlation, updating, and report generation. The system is capable of departing on an assigned mission, collecting required data, recording which portions of its mission had to be aborted or modified due to environmental constraints, and reporting back when the mission is complete. Successful identification of more than 96% of drum defects has been demonstrated in a high fidelity waste storage facility mockup. Identified anomalies included rust spots, rust streaks, areas of corrosion, dents, and tilted drums. All drums were positively identified and correlated with the site database. This development effort was separated into three phases of which phase three is now complete. The first phase demonstrated an integrated system (maturity level IVa) for monitoring and inspection activities for waste storage facility operations. The second phase demonstrated a prototype system appropriate for operational use in an actual storage facility. The prototype employed an integrated design that considered operational requirements, hardware costs, maintenance, safety, and robustness. The final phase has demonstrated the commercial viability of the vehicle in operating waste storage facilities at Fernald, Ohio and the Idaho National Engineering Laboratory (INEL). This report summarizes the system upgrades performed in phase 3 and the evaluation of the IMSS Phase 3 system and vehicle.

  4. Intelligent mobile sensor system for drum inspection and monitoring: Phase 1. Topical report, October 1, 1992--June 8, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    The objective of this project was to develop an operational system for monitoring and inspection activities for waste storage facility operations at several DOE sites. Specifically, the product of this effort is a robotic device with enhanced intelligence and maneuverability capable of conducting routine inspection of stored waste drums. The device is capable of operating in narrow aisles and interpolating the free aisle space between rows of stacked drums. The system has an integrated sensor suite for leak detection, and is interfaced with a site database both for inspection planning and for data correlation, updating, and report generation. The system is capable of departing on an assigned mission, collecting required data, recording which positions of its mission had to be aborted or modified due to environmental constraints, and reporting back when the mission is complete. Successful identification of more than 90% of all drum defects has been demonstrated in a high fidelity waste storage facility mockup. Identified anomalies included rust spots, rust streaks, areas of corrosion, dents, and tilted drums. All drums were positively identified and correlated with the site database. This development effort is separated into three phases of which phase one is now complete. The first phase has demonstrated an integrated system for monitoring and inspection activities for waste storage facility operations. This demonstration system was quickly fielded and evaluated by leveraging technologies developed from previous NASA and DARPA contracts and internal research. The second phase will demonstrate a prototype system appropriate for operational use in an actual storage facility. The prototype provides an integrated design that considers operational requirements, hardware costs, maintenance, safety, and robustness. The final phase will demonstrate commercial viability using the prototype vehicle in a pilot waste operations and inspection project.

  5. Effects of relative sea level changes on facies and diagenetic variability of a Pennsylvanian outcrop and near-surface reservoir analog, SE Kansas (Missourian, Drum Limestone)

    Energy Technology Data Exchange (ETDEWEB)

    Gomez-Perez, I. [Univ. of Wisconsin, Madison, WI (United States); Fieldman, H.R.; Franseen, E.K. [Kansas Geological Survey, Lawrence, KS (United States)] [and others

    1995-08-01

    The Drum Limestone contains facies that are an analog to important petroleum reservoirs elsewhere in the Mid-continent. It consists predominantly of an oolitic shoal and algal buildup complex deposited and the seaward edge of a shale delta. This study integrates outcrop, core, well log, petrographic, and high-resolution reflection seismic data to understand the role of relative sea level fluctuations in the depositional and diagenetic history of the Drum reservoir facies. The Drum Limestone forms an E-W belt 30 km wide, is up to 21 m thick, and thins to less than one meter thick both up-dip and down-dip of the depositional shelf edge. The basal contact of the Drum Limestone is regionally erosive and interpreted to represent a relative sea level drop. The erosion surface is overlain by a basal oolite with lithoclasts. Two-thirds of the Drum oolite facies coexisted partially with algal-bryozoan buildups, in shallow-waters at the shelf edge. Ooids were likely transported by tidal and wave currents to paleotopographic lows forming basinward prograding (SSW direction) clinoforms. Landward, Drum facies grade to stromatolites, and basinward the oolite pinches out. An interpreted relative sea level fall at the end of this Drum depositional stage resulted in a sharp, regionally traceable surface with evidences of likely subaerial exposure in shelf positions, and represented basinward by an oolitic lithoclastic breccia capped by an incipient hardground. The surface is overlain by Drum trough-crossbedded (N-NE direction) bioclastic oolitic facies interbedded with shales, deposited during a relative sea level rise. This upper third of oolite deposition was influenced by siliciclastic input from the south that eventually overtook carbonate sedimentation. Facies and diagenetic changes documented for the Drum Limestone analog are providing important details on reservoir heterogeneities at a scale important for Mid-continent reservoirs.

  6. The nutritional quality of drum-dried algae produced in open door mass culture.

    Science.gov (United States)

    Saleh, A M; Hussein, L A; Abdalla, F E; el-Fouly, M M; Shaheen, A B

    1985-12-01

    The yield of three large scale cultures of Scenedesmus acutus, Chlorella vulgaris, and Coelastrum proboscideum was drum dried. The amino acid composition of the three species proved to compare well with the FAO (11) amino acid pattern except for methionine and isoleucine. Bio-assay evaluation of the three algal proteins gave the following values: protein efficiency ratio, 1.9-2.1; net protein ratio, 2,4-2.8; biological value, 75-78; digestibility coefficient 88-89; and calculated net protein utilization 67-69. Total nucleic acid content was about 4%. Uric acid content in the plasma of rats fed Scenedesmus, Chlorella, and Coelastrum diets was significantly higher (P less than 0.05) than in plasma of rats fed on a casein diet.

  7. Fissile and non-fissile element separation in concrete radioactive waste drums using the SIMPHONIE method

    Energy Technology Data Exchange (ETDEWEB)

    Jallu, F. E-mail: fanny.jallu@cea.fr; Lyoussi, A.; Passard, C.; Payan, E.; Recroix, H.; Nurdin, G.; Buisson, A.; Allano, J

    2001-07-01

    The simultaneous photon and neutron interrogation experiment (SIMPHONIE) method, applied to radioactive waste drum characterization, has already been treated in [F. Jallu, A. Lyoussi, C. Passard, E. Payan, H. Recroix, G. Nurdin, A. Buisson, J. Allano, Nucl. Instr. and Meth. B 170 (2000) 489]. First experimental results carried out with U and Pu bare samples were presented, that showed the feasibility of quantifying fissile ({sup 235}U, {sup 239,241}Pu, ...) and non-fissile ({sup 234,236,238}U, {sup 238,240}Pu, ...) elements separately in only one measurement, using both active neutron interrogation and induced photofission interrogation techniques simultaneously. This paper presents new experimental results carried out with U samples embedded in a concrete matrix. These results have been obtained using the DGA/ETCA MiniLinatron pulsed linear electron accelerator located at Arcueil, France. Mass detection limits of less than 2 g of matter have been obtained with the preliminary setup used in these experiments.

  8. Numerical simulation of two-dimensional steady granular flows in rotating drum: On surface flow rheology

    Science.gov (United States)

    Renouf, M.; Bonamy, D.; Dubois, F.; Alart, P.

    2005-10-01

    The rheology of two-dimensional steady surface flow of cohesionless cylinders in a rotating drum is investigated through nonsmooth contact dynamics simulations. Profiles of volume fraction, translational and angular velocity, rms velocity, strain rate, and stress tensor are measured at the midpoint along the length of the surface-flowing layer, where the flow is generally considered as steady and homogeneous. Analysis of these data and their interrelations suggest the local inertial number—defined as the ratio between local inertial forces and local confinement forces—to be the relevant dimensionless parameter to describe the transition from the quasistatic part of the packing to the flowing part at the surface of the heap. Variations of the components of the stress tensor as well as the ones of rms velocity as a function of the inertial number are analyzed within both the quasistatic and the flowing phases. Their implications are discussed.

  9. The Comparative Analysis and Evaluation of Ecological Characteristics of Drum and Disk Wheel Brakes

    Directory of Open Access Journals (Sweden)

    Aleksandr Revin

    2011-04-01

    Full Text Available It is well-known that automobile transport as well as industry are the main sources of air pollution. In addition to exhaust gases, the flow of traffic releases a cloud of dust, consisting of over 60% of micro- and ultramicroscopic particles with radius of 10.0–0.25 µm, which are formed due to wheel abrasion (caused by the road grip of a tyre and the use of the brake blocks (in braking. The products formed in the process of wearing of the wheel brake pads are also the sources of the mass of fine dispersed particles over an urban highway. The authors analyse and evaluate ecological characteristics of drum and disk wheel brakes of vehicles.Article in Russian

  10. Composting domestic sewage sludge with natural zeolites in a rotary drum reactor.

    Science.gov (United States)

    Villaseñor, J; Rodríguez, L; Fernández, F J

    2011-01-01

    This work aimed the influence of zeolites addition on a sludge-straw composting process using a pilot-scale rotary drum reactor. The type and concentration of three commercial natural zeolites were considered: a mordenite and two clinoptilolites (Klinolith and Zeocat). Mordenite caused the greatest carbon removal (58%), while the clinoptilolites halved losses of ammonium. All zeolites removed 100% of Ni, Cr, Pb, and significant amounts (more than 60%) of Cu, Zn and Hg. Zeocat displayed the greatest retention of ammonium and metals, and retention efficiencies increased as Zeocat concentration increased. The addition of 10% Zeocat produced compost compliant with Spanish regulations. Zeolites were separated from the final compost, and leaching studies suggested that zeolites leachates contained very low metals concentrations (zeolites could be separated from the compost prior to application. The different options have been discussed.

  11. A rotary drum screen with internal screw flights for Eri silkworm pupae

    Directory of Open Access Journals (Sweden)

    Kanjanawanishkul Kiattisin

    2015-01-01

    Full Text Available Eri silkworm pupae (Samia ricini are very interesting creatures since they can be developed as a sustainable high protein food source for human beings and animals, and their cocoons can be used for silk production. At present, Thai silk is very famous for its special qualities, whereas the requirement of pupae as food grows increasingly, in particular, canned pupae with seasoning favors. Like other food products, size uniformity is required. Therefore, in this paper, a rotary drum screen with internal screw flights was designed and constructed for separating Eri silkworm pupae into two groups with different sizes. The experiments were conducted to evaluate its effectiveness. The results show that the optimal angular speed of the screen was 20 rpm and the screw pitch value was 10 cm. These parameters resulted in the accuracy percentage of pupa screening of 94.3% and the working capacity of 8.6 kg/h.

  12. Modeling and Simulation of Coal Loading by Cutting Drum in Flat Seams

    Science.gov (United States)

    Gospodarczyk, Piotr

    2016-06-01

    This paper presents a methodology for modeling work of a coal shearer work in low longwall coal seams where the wall height does not exceed 1.5 m. In such conditions, an important issue is the process of loading the ore from shearer cutting drum on an armored face conveyor and selection of appropriate kinematic parameters to avoid choking. Discrete element method was used to model coal seam. This method allows for efficient simulation of physical systems composed of many separate components. Methods and algorithms based on existing theoretical models were developed to imitate coal cutting process. Main focus of analysis was put on coal stream movement for different variants of the shearer construction and kinematic parameters.

  13. THE BODIES COALESCED WITH HISTORY IN RUSHDIE'S MIDNIGHT'S CHILDREN AND GRASS' THE TIN DRUM

    Directory of Open Access Journals (Sweden)

    Faruk KALAY

    2013-06-01

    Full Text Available Salman Rushdie and Günter Grass always attract the readers' attention with their fabulous novels. In their novels titled Tin Drum by Günter Grass and Midnight's Children by Salman Rushdie having much importance to irradiate their homeland's history, the authors indicate the most important incidences in their history. While Grass deals with Hitler's period and his aftermath, Rushdie concerns about the birth of independent India. Both writers pen the advantage and disadvantage aspects of the then term in the society. A great number of terms, such as identity, history, postmodernism, intertextuality, histographic metafiction can be easily observed in the novels. In this context, the protagonists of these two novels have the same destiny with their homeland, which is emphasized in this study.

  14. Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing

    Institute of Scientific and Technical Information of China (English)

    Ji Xu; Jing hai Li; Hua biao Qi; Xiao jian Fang; Li qiang Lu; Wei Ge; Xiao wei Wang; Ming Xu; Fei guo Chen; Xian feng He

    2011-01-01

    Real-time simulation of industrial equipment is a huge challenge nowadays.The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals.In this article,an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation.A single GPU is used first to simulate a small model system with about 8000 particles in real-time,and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode.The overall speed is about 1/11 of the real-time.Optimization of the communication part of the parallel GPU codes can speed up the simulation further,indicating that such real-time simulations have not only methodological but also industrial implications in the near future.

  15. Eruptive history and petrology of Mount Drum volcano, Wrangell Mountains, Alaska

    Science.gov (United States)

    Richter, D.H.; Moll-Stalcup, E. J.; Miller, T.P.; Lanphere, M.A.; Dalrymple, G.B.; Smith, R.L.

    1994-01-01

    Mount Drum is one of the youngest volcanoes in the subduction-related Wrangell volcanic field (80x200 km) of southcentral Alaska. It lies at the northwest end of a series of large, andesite-dominated shield volcanoes that show a northwesterly progression of age from 26 Ma near the Alaska-Yukon border to about 0.2 Ma at Mount Drum. The volcano was constructed between 750 and 250 ka during at least two cycles of cone building and ring-dome emplacement and was partially destroyed by violent explosive activity probably after 250 ka. Cone lavas range from basaltic andesite to dacite in composition; ring-domes are dacite to rhyolite. The last constructional activity occured in the vicinity of Snider Peak, on the south flank of the volcano, where extensive dacite flows and a dacite dome erupted at about 250 ka. The climactic explosive eruption, that destroyed the top and a part of the south flank of the volcano, produced more than 7 km3 of proximal hot and cold avalanche deposits and distal mudflows. The Mount Drum rocks have medium-K, calc-alkaline affinities and are generally plagioclase phyric. Silica contents range from 55.8 to 74.0 wt%, with a compositional gap between 66.8 and 72.8 wt%. All the rocks are enriched in alkali elements and depleted in Ta relative to the LREE, typical of volcanic arc rocks, but have higher MgO contents at a given SiO2, than typical orogenic medium-K andesites. Strontium-isotope ratios vary from 0.70292 to 0.70353. The compositional range of Mount Drum lavas is best explained by a combination of diverse parental magmas, magma mixing, and fractionation. The small, but significant, range in 87Sr/86Sr ratios in the basaltic andesites and the wide range of incompatible-element ratios exhibited by the basaltic andesites and andesites suggests the presence of compositionally diverse parent magmas. The lavas show abundant petrographic evidence of magma mixing, such as bimodal phenocryst size, resorbed phenocrysts, reaction rims, and

  16. Hypoxia tolerance decreases with body size in red drum Sciaenops ocellatus.

    Science.gov (United States)

    Pan, Y K; Ern, R; Esbaugh, A J

    2016-08-01

    Mass-specific oxygen consumption rate, i.e. standard metabolic rate (Rs ) and critical oxygen tension (Pcrit ) of red drum Sciaenops ocellatus were measured and scaled over a 2500-fold range in mass (MF ; 0·26-686 g). Rs conformed to well established models (Rs  = 3·73·91 MF (-0·21) ; r(2)  = 0·86) while Pcrit increased over the size range (Pcrit  = 3·15 log10 MF  + 16·19; r(2)  = 0·44). This relationship may be ecologically advantageous as it would allow smaller S. ocellatus to better utilize hypoxic zones as habitat and refuge from predators.

  17. Detecting the mass and position of an adsorbate on a drum resonator.

    Science.gov (United States)

    Zhang, Y; Zhao, Y P

    2014-10-08

    The resonant frequency shifts of a circular membrane caused by an adsorbate are the sensing mechanism for a drum resonator. The adsorbate mass and position are the two major (unknown) parameters determining the resonant frequency shifts. There are infinite combinations of mass and position which can cause the same shift of one resonant frequency. Finding the mass and position of an adsorbate from the experimentally measured resonant frequencies forms an inverse problem. This study presents a straightforward method to determine the adsorbate mass and position by using the changes of two resonant frequencies. Because detecting the position of an adsorbate can be extremely difficult, especially when the adsorbate is as small as an atom or a molecule, this new inverse problem-solving method should be of some help to the mass resonator sensor application of detecting a single adsorbate. How to apply this method to the case of multiple adsorbates is also discussed.

  18. The Stringed Drum and the 16th Century Music: New Iconographical Sources

    Directory of Open Access Journals (Sweden)

    Ballester i Gibert, Jordi

    2011-12-01

    Full Text Available The present paper deals with a stringed drum depicted in an anonymous Catalan panel from the mid 16th century. The panel, coming from the church of Barruera (Boí valley, disappeared during the Spanish Civil War and we only have a black and white photography kept in the Institut Amatller d’Art Hispànic in Barcelona. Nevertheless, the study of this depiction shows several aspects related to the instrument and its musical use. Some of these aspects allow us to deal with different hypothesis connecting the stringed drum with the performance practice: on the one hand the instrument appears in a courtly renaissance atmosphere, being played at a banquet; on the other hand the instrument appears not only accompanying the one-hand flute (as it can be seen in other depictions but also making up a consort together with a fiddle.

    El presente artículo se centra en la representación, hasta ahora desconocida, de un tambor de cuerdas pintado en una tabla anónima catalana de mediados del siglo XVI, procedente de la pequeña iglesia de Barruera (Vall de Boí. Dicha tabla desapareció durante la guerra civil española y solo la conocemos a través de una fotografía en blanco y negro que se conserva en el Instituto Amatller de Arte Hispánico (Barcelona. No obstante, el estudio de la representación clarifica algunos aspectos relativos al uso del instrumento que hasta ahora no se habían podido demostrar: por un lado nos sitúa el tambor de cuerdas en el contexto de un banquete cortesano de ambiente renacentista; por otro lado relaciona el instrumento no solo con su acompañante habitual – la flauta de una sola mano – sino también con la viola de arco.

  19. Non-destructive assay of drum package radioactive wastes utilizing tomographic gamma scanning

    Energy Technology Data Exchange (ETDEWEB)

    Ausbrooks, K. L. [Univ. of Tennessee, Knoxville, TN (United States)

    1996-05-01

    A methodology for nondestructive assay of drum packaged radioactive waste materials is investigated using Emission Computed Tomography procedures. A requirement of this method is accurate gamma attenuation correction. This is accomplished by the use of a constant density distribution for the drum content, thereby requiring the need for a homogeneous medium. The current predominant NDA technique is the use of the Segmented Gamma Scanner. Tomographic Gamma Scanning improves upon this method by providing a low resolution three-dimensional image of the source distribution, yielding both spatial and activity information. Reconstruction of the source distribution is accomplished by utilization of algebraic techniques with a nine by six voxel model with detector information gathered over scanning intervals of ninety degrees. Construction of a linear system to describe the scenario was accomplished using a point-source response function methodology, where a 54 x 120 matrix contained the projected detector responses for each source-detector geometry. Entries in this matrix were calculated using the point-kernal shielding code QAD-CGGP. Validation was performed using the MCNP photon transport code. Solutions to the linear system were determined using the Non-Negative Least Squares (NNLS) algorithm and the LSMOD algorithm. A series of four scans were performed, each reconstructing the source distribution of a mock-up waste package containing a single 73 mCi 137Cs point source. For each scan, the source was located in a different location. Results of the reconstruction routines accurately predict the location and activity of the source. The range of activity calculated using the NNLS routine is 0.2681 mCi with an average value of 77.7995 mCi. The range of values calculated using LSMOD is 5.1843 mCi with an average of 72.8018 mCi.

  20. High-Energy X-Ray Imaging Applied to Nondestructive Characterization of Large Nuclear Waste Drums

    Science.gov (United States)

    Estre, Nicolas; Eck, Daniel; Pettier, Jean-Luc; Payan, Emmanuel; Roure, Christophe; Simon, Eric

    2015-12-01

    As part of its R&D programs on non-destructive testing of nuclear waste drums, CEA is commissioning an irradiation cell named CINPHONIE, at Cadarache. This cell allows high-energy imaging (radiography and tomography) on large volumes (up to 5 m3) and heavy weights (up to 5 tons). A demonstrator has been finalized, based on existing components. The X-ray source is a 9 MeV LINAC which produces Bremsstrahlung X-rays (up to 23 Gy/min at 1 meter in the beam axis). The mechanical bench is digitally controlled on three axes (translation, rotation, elevation) and can handle objects up to 2 t. This bench performs trajectories necessary for acquisition of projections (sinograms) according to different geometries: Translation-Rotation, Fan-Beam and Cone-Beam. Two detection systems both developed by CEA-Leti are available. The first one is a large GADOX scintillating screen ( 800 ×600 mm2) coupled to a low-noise pixelated camera. The second one is a multi-CdTe semiconductor detector, offering measurements up to 5 decades of attenuation (equivalent to 25 cm of lead or 180 cm of standard concrete). At the end of the acquisition, a Filtered Back Projection-based algorithm is performed. Then, a density slice (fan-beam tomography) or a density volume (cone-beam tomography or helical tomography) is produced and used to examine the waste. Characterization of LINAC, associated detectors as well as the full acquisition chain, are presented. Experimental performances on phantoms and real drum are discussed and expected limits on defect detectability are evaluated by simulation. The final system, designed to handle objects up to 5 tons is then presented.

  1. Gamma-ray spectrometry method used for radioactive waste drums characterization for final disposal at National Repository for Low and Intermediate Radioactive Waste--Baita, Romania.

    Science.gov (United States)

    Done, L; Tugulan, L C; Dragolici, F; Alexandru, C

    2014-05-01

    The Radioactive Waste Management Department from IFIN-HH, Bucharest, performs the conditioning of the institutional radioactive waste in concrete matrix, in 200 l drums with concrete shield, for final disposal at DNDR - Baita, Bihor county, in an old exhausted uranium mine. This paper presents a gamma-ray spectrometry method for the characterization of the radioactive waste drums' radionuclides content, for final disposal. In order to study the accuracy of the method, a similar concrete matrix with Portland cement in a 200 l drum was used. © 2013 The Authors. Published by Elsevier Ltd All rights reserved.

  2. An evaluation of Northern Florida Bay as a nursery area for red drum, Sciaenops ocellatus, and other juvenile and small resident fishes.

    OpenAIRE

    Powell, Allyn B.; LaCroix, Michael W.; Cheshire, Robin T.

    2002-01-01

    Red drum is one ofthe most popular species sought by anglers in Florida Bay, yet juveniles are rarely encountered. We evaluated Florida Bay as a nursery area for red drum by sampling for recently-settled late larvae in basin areas within the bay with an epi-benthic sled at six stations in November 2000, and at seven stations during December 2000 through February 2001. In November 2000 we surveyed potential sampling sites in quiet backwaters adjacent to mangroves for juvenile red drum. A to...

  3. Structural elucidation of the nonclassical secondary cell wall polysaccharide from Bacillus cereus ATCC 10987. Comparison with the polysaccharides from Bacillus anthracis and B. cereus type strain ATCC 14579 reveals both unique and common structural features.

    Science.gov (United States)

    Leoff, Christine; Choudhury, Biswa; Saile, Elke; Quinn, Conrad P; Carlson, Russell W; Kannenberg, Elmar L

    2008-10-31

    Nonclassical secondary cell wall polysaccharides constitute a major cell wall structure in the Bacillus cereus group of bacteria. The structure of the secondary cell wall polysaccharide from Bacillus cereus ATCC 10987, a strain that is closely related to Bacillus anthracis, was determined. This polysaccharide was released from the cell wall with aqueous hydrogen fluoride (HF) and purified by gel filtration chromatography. The purified polysaccharide, HF-PS, was characterized by glycosyl composition and linkage analyses, mass spectrometry, and one- and two-dimensional NMR analysis. The results showed that the B. cereus ATCC 10987 HF-PS has a repeating oligosaccharide consisting of a -->6)-alpha-GalNAc-(1-->4)-beta-ManNAc-(1-->4)-beta-GlcNAc-(1--> trisaccharide that is substituted with beta-Gal at O3 of the alpha-GalNAc residue and nonstoichiometrically acetylated at O3 of the N-acetylmannosamine (ManNAc) residue. Comparison of this structure with that of the B. anthracis HF-PS and with structural data obtained for the HF-PS from B. cereus type strain ATCC 14579 revealed that each HF-PS had the same general structural theme consisting of three HexNAc and one Hex residues. A common structural feature in the HF-PSs from B. cereus ATCC 10987 and B. anthracis was the presence of a repeating unit consisting of a HexNAc(3) trisaccharide backbone in which two of the three HexNAc residues are GlcNAc and ManNAc and the third can be either GlcNAc or GalNAc. The implications of these results with regard to the possible functions of the HF-PSs are discussed.

  4. 论巴渝民间艺术“小河锣鼓”的传承和保护%The Inheritance and Protection of Bayu Folk Art Xiaohe Drum

    Institute of Scientific and Technical Information of China (English)

    杨翠碧; 简春燕

    2016-01-01

    The Xiaohe Drum, one of the third set of national non-material culture heritage items, is a combination of folk musical instruments with prominent artistry and tense local characteristics. But its artistic and cultural value has not been stressed and thus its inheritance is not well conducted. The inheritance and protection of Xiohe Drum shall be guaranteed on the condition that its contents and forms shall be continuously innovated, the subject and forms of inheritance changed and it supported by governments, public cultural institutions and the common people.%被列为第三批国家级非物质文化遗产的小河锣鼓是巴渝地区一种独特的民间器乐组合,具有鲜明的艺术特色及浓郁的地域文化特征。但其艺术及文化价值却长期未能得到充分重视,传承严重受阻。为更好地传承与保护小河锣鼓,需不断革新内容与形式、改变传承方式与主体,大力争取政府部门、公共文化机构及广大民众的支持与帮助。

  5. The development of the Acehnese sitting song-dances and frame-drum genres as part of religious conversion and continuing piety

    Directory of Open Access Journals (Sweden)

    Margaret Kartomi

    2010-04-01

    Full Text Available The development of the Acehnese sitting song-dances and frame-drum genres as part of religious conversion and continuing piety This article aims to connect two important genres of Aceh

  6. Final evaluation report for Westinghouse Hanford Company, WRAP-1,208 liter waste drum, docket 94-35-7A, type A packaging

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, D.L., Westinghouse Hanford

    1996-06-12

    This report documents the U.S. Department of Transportation Specification 7A Type A (DOT-7A) compliance test results of the Westinghouse Hanford Company, Waste Receiving and Processing Facility, Module 1 (WRAP-1) Drum. The WRAP-1 Drum was tested for DOE-HQ in August 1994, by Los Alamos National Laboratory, under docket number 94-35-7A. Additionally, comparison and evaluation of the approved, as-tested packaging configuration was performed by WHC in September 1995. The WRAP-1 Drum was evaluated against the performance of the DOT-17C, 208 1 (55-gal) steel drums tested and evaluated under dockets 89-13-7A/90-18-7A and 94-37-7A.

  7. Protein-Protein Interaction and Pathway Analyses of Top Schizophrenia Genes Reveal Schizophrenia Susceptibility Genes Converge on Common Molecular Networks and Enrichment of Nucleosome (Chromatin) Assembly Genes in Schizophrenia Susceptibility Loci

    OpenAIRE

    Luo, Xiongjian; Huang, Liang; Jia, Peilin; Li, Ming; SU, Bing; Zhao, Zhongming; Gan, Lin

    2013-01-01

    Recent genome-wide association studies have identified many promising schizophrenia candidate genes and demonstrated that common polygenic variation contributes to schizophrenia risk. However, whether these genes represent perturbations to a common but limited set of underlying molecular processes (pathways) that modulate risk to schizophrenia remains elusive, and it is not known whether these genes converge on common biological pathways (networks) or represent different pathways. In addition...

  8. Drawworks Drum Reliability Research Based on Probabilistic FEM Method%基于概率有限元法的绞车滚筒可靠性研究

    Institute of Scientific and Technical Information of China (English)

    董辉

    2016-01-01

    滚筒是绞车的重要组成部分,为保证钻井作业安全、 顺利进行,对钻机绞车滚筒进行可靠性分析有着十分重要的意义.针对影响滚筒可靠性因素复杂的情况,提出了基于Monte-Carlo概率有限元法求解滚筒可靠度的方法.分析得到滚筒壳的可靠度为0.988038,同理计算出滚筒其余构件的可靠度,各构件可靠度相乘得到滚筒可靠度,计算结果与实际结果基本相符,表明将Monte-Carlo概率有限元法应用在滚筒可靠性分析中切实可行,同时得到要提高滚筒壳的可靠度,应增大壳体壁厚,减小外载.所得结论为滚筒壳设计提供了理论依据.%Reliability analysis of the drawworks drum has a very important significance on ensuring the drilling operation safety. To address the complex factors that affect the reliability of the drum, a method addressing the drum reliability based on Monte-Carlo probabilistic finite element method has been proposed. Based on the analysis, the reliability of the drum shell is 0.988038, and the reliability of the rest of the drum components was calculated by the same way. The drum reliability then could be attained by multiplying the reliability of each component of the drum. The calculated result is basically consistent with the actual result, validating the Monte-Carlo probabilistic fi-nite element method for the drawworks drum reliability calculation. Enhanced drum shell wall thickness and reduced external load could improve the drum shell reliability. The method provides a theoretical basis for the design of the drum shell.

  9. Feasibility study of {sup 235}U and {sup 239}Pu characterization in radioactive waste drums using neutron-induced fission delayed gamma rays

    Energy Technology Data Exchange (ETDEWEB)

    Nicol, T. [CEA, DEN, Cadarache, Nuclear Measurement Laboratory, F-13108 Saint-Paul-lez-Durance (France); FZJ, Institute of Energy and Climate Research – Nuclear Waste Management and Reactor Safety, Wilhelm-Johnen-Straße, d-52425 Jülich (Germany); Pérot, B., E-mail: bertrand.perot@cea.fr [CEA, DEN, Cadarache, Nuclear Measurement Laboratory, F-13108 Saint-Paul-lez-Durance (France); Carasco, C. [CEA, DEN, Cadarache, Nuclear Measurement Laboratory, F-13108 Saint-Paul-lez-Durance (France); Brackx, E. [CEA, DEN, Marcoule, Metallography and Chemical Analysis Laboratory, F-30207 Bagnols-sur-Cèze (France); Mariani, A.; Passard, C. [CEA, DEN, Cadarache, Nuclear Measurement Laboratory, F-13108 Saint-Paul-lez-Durance (France); Mauerhofer, E. [FZJ, Institute of Energy and Climate Research – Nuclear Waste Management and Reactor Safety, Wilhelm-Johnen-Straße, d-52425 Jülich (Germany); Collot, J. [Laboratoire de Physique Subatomique et de Cosmologie, Université Grenoble Alpes, CNRS/IN2P3 Grenoble (France)

    2016-10-01

    This paper reports a feasibility study of {sup 235}U and {sup 239}Pu characterization in 225 L bituminized waste drums or 200 L concrete waste drums, by detecting delayed fission gamma rays between the pulses of a deuterium-tritium neutron generator. The delayed gamma yields were first measured with bare samples of {sup 235}U and {sup 239}Pu in REGAIN, a facility dedicated to the assay of 118 L waste drums by Prompt Gamma Neutron Activation Analysis (PGNAA) at CEA Cadarache, France. Detectability in the waste drums is then assessed using the MCNPX model of MEDINA (Multi Element Detection based on Instrumental Neutron Activation), another PGNAA cell dedicated to 200 L drums at FZJ, Germany. For the bituminized waste drum, performances are severely hampered by the high gamma background due to {sup 137}Cs, which requires the use of collimator and shield to avoid electronics saturation, these elements being very penalizing for the detection of the weak delayed gamma signal. However, for lower activity concrete drums, detection limits range from 10 to 290 g of {sup 235}U or {sup 239}Pu, depending on the delayed gamma rays of interest. These detection limits have been determined by using MCNPX to calculate the delayed gamma useful signal, and by measuring the experimental gamma background in MEDINA with a 200 L concrete drum mock-up. The performances could be significantly improved by using a higher interrogating neutron emission and an optimized experimental setup, which would allow characterizing nuclear materials in a wide range of low and medium activity waste packages.

  10. Reconstruction of the activity of point sources for the accurate characterization of nuclear waste drums by segmented gamma scanning.

    Science.gov (United States)

    Krings, Thomas; Mauerhofer, Eric

    2011-06-01

    This work improves the reliability and accuracy in the reconstruction of the total isotope activity content in heterogeneous nuclear waste drums containing point sources. The method is based on χ(2)-fits of the angular dependent count rate distribution measured during a drum rotation in segmented gamma scanning. A new description of the analytical calculation of the angular count rate distribution is introduced based on a more precise model of the collimated detector. The new description is validated and compared to the old description using MCNP5 simulations of angular dependent count rate distributions of Co-60 and Cs-137 point sources. It is shown that the new model describes the angular dependent count rate distribution significantly more accurate compared to the old model. Hence, the reconstruction of the activity is more accurate and the errors are considerably reduced that lead to more reliable results. Furthermore, the results are compared to the conventional reconstruction method assuming a homogeneous matrix and activity distribution.

  11. PLANT SPACING AND WEED MANAGEMENT TECHNIQUES INFLUENCE WEED COMPETITIVENESS OF DRUM SEEDED RICE (Oryza sativa L.

    Directory of Open Access Journals (Sweden)

    B N Sandeep Nayak

    2014-11-01

    Full Text Available Direct wet seeded-rice sown through drum seeder, a potential wise rice production system in the present-day scenario, is subject to severe weed infestation and, therefore, development of a sustainable weed management strategy is crucial for its wide spread adoption. The present study was conducted in kharif 2012 at department of agronomy division with NLR-33358 (SOMASILA using six planting densities under five weed management conditions. The plant spacing tried were: 20cm x 7cm, 20 cm x 10.5 cm, 20 cm x 14 cm, 20 cm x 17.5 cm and 20 cm x 24.5cm and 20 cm x15cm. with a plant density of 71, 47, 35, 28, 20 and 33 hills m-2, respectively and five weed management practices viz., weedy check (W1, hand weeding at 20 and 40 DAS (W2, cono weeding at 20 and 40 with modified cono weeder (W3, pre-emergence application of anilofos @ 0.375 kg a.i ha-1 followed by post-emergence application of 2, 4 D sodium salt @ 1.0 kg a.i ha-1 20-25 DAS (W4, pre-emergence application of pendimethalin @1.0 kg a.i ha-1 followed by post-emergence application of bispyribac sodium @ 20 g a.i ha-1 30 DAS ( W5. . The experiment was laid out in strip- plot design with three replications assigning weed management techniques in vertical factor and plant spacing in horizontal factor. Direct wet seeded rice field was infested with 12 and 22 weed species, kharif -2012 season having Echinochloa colona, Leptochloa chinensis, Digitaria aescendens, Cyperus iriaand Eleusine indicaas the predominant weeds. Rice spacing exerted significant influence on both weed pressure and yield performance of crop. With the increase in plant spacing weed dry matter decreased but rice yield increased. In this season, among different plant densities, the highest density of 71 hills m-2(D1 resulted in minimum weed density, weed drymatter, and more number of tillers m-2 and maximum drymatter production at all stages of plant growth. closest spacing resulted in maximum weed suppression, but among various rice

  12. Species Profiles. Life Histories and Environmental Requirements of Coastal Fishes and Invertebrates (Gulf of Mexico). RED DRUM.

    Science.gov (United States)

    1985-06-01

    highest at 25°C. Growth rates of long. In the upper Laguna Madre , postlarvae increased with increases in Texas , Miles (1950) reported ripe salinity (up...requirements of red drum; Seagrass provides habitat for food, however, low oxygen in lower Laguna and protection from predators. In Madre , Texas , is known...year round In Texas , Pearson (1928) reported (Simmons and Breuer 1962). that the estimated average lengths of fish of ages I to III were as follows

  13. Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users.

    Directory of Open Access Journals (Sweden)

    Daisy Fancourt

    Full Text Available Growing numbers of mental health organizations are developing community music-making interventions for service users; however, to date there has been little research into their efficacy or mechanisms of effect. This study was an exploratory examination of whether 10 weeks of group drumming could improve depression, anxiety and social resilience among service users compared with a non-music control group (with participants allocated to group by geographical location. Significant improvements were found in the drumming group but not the control group: by week 6 there were decreases in depression (-2.14 SE 0.50 CI -3.16 to -1.11 and increases in social resilience (7.69 SE 2.00 CI 3.60 to 11.78, and by week 10 these had further improved (depression: -3.41 SE 0.62 CI -4.68 to -2.15; social resilience: 10.59 SE 1.78 CI 6.94 to 14.24 alongside significant improvements in anxiety (-2.21 SE 0.50 CI -3.24 to -1.19 and mental wellbeing (6.14 SE 0.92 CI 4.25 to 8.04. All significant changes were maintained at 3 months follow-up. Furthermore, it is now recognised that many mental health conditions are characterised by underlying inflammatory immune responses. Consequently, participants in the drumming group also provided saliva samples to test for cortisol and the cytokines interleukin (IL 4, IL6, IL17, tumour necrosis factor alpha (TNFα, and monocyte chemoattractant protein (MCP 1. Across the 10 weeks there was a shift away from a pro-inflammatory towards an anti-inflammatory immune profile. Consequently, this study demonstrates the psychological benefits of group drumming and also suggests underlying biological effects, supporting its therapeutic potential for mental health.ClinicalTrials.gov NCT01906892.

  14. A Drumming Dance: A Study on the Effects of West African Dance on Motor Performance and Motivation among Collegiate Dancers

    OpenAIRE

    Wajid-Ali, Darlisa Gloria

    2016-01-01

    Changes in cardiovascular health, balance, agility, and motivation were assessed during a 6-week West African dance and live drumming intervention with collegiate dancers. The study measured cardiovascular health with the Accelerated 3-Minute Step test, balance with the m/r Star Excursion Balance test, and agility with the Illinois Agility test. Motivation was measured using the Classroom Life Measure, Motivated Strategies Learning Questionnaire, and the Rosenberg Self-Esteem Scale. The inter...

  15. Development of rotary drum shale shaker%旋转滚筒振动筛的研制

    Institute of Scientific and Technical Information of China (English)

    兰东海; 张鹏; 蒋建华; 刘新香

    2001-01-01

    This paper intends to introduce the development of rotary drumshale shaker.The rotary drum shale shaker has synthesized rotation,vibration and rolling.Its drum is constructed of special stainless wire screen which can raise the solid control efficiency .This paper introduces its machinery structure,working principle and on-site experimental effectiveness.The rotary drum shale shaker has been patented with No:ZL 93 2 08282.3.%旋转滚筒振动筛集滚动、振动及旋转等运动于一体,筒式筛网由具有一定几何形状的特制不锈钢细筛网组成,从而提高了除砂效果。现文介绍了其结构、原理与现场试验情况,该旋转滚筒振动筛已获得国家专利(ZL93208282.3)。

  16. Active particle control in the CPD compact spherical tokamak by a lithium-gettered rotating drum limiter

    Energy Technology Data Exchange (ETDEWEB)

    Hirooka, Y., E-mail: hirooka.yoshihiko@nifs.ac.j [National Institute for Fusion Science, Oroshi, Toki, Gifu 509-5292 (Japan); Zushi, H. [Kyushu University, Kasuga, Fukuoka 816-8580 (Japan); Bhattacharyay, R. [Interdisciplinary Graduate School of Engineering Science, Kyushu University, Kasuga, Fukuoka 816-8580 (Japan); Sakamoto, M.; Idei, H.; Yoshinaga, T. [Kyushu University, Kasuga, Fukuoka 816-8580 (Japan); Nakashima, Y.; Higashizono, Y. [University of Tsukuba, Tsukuba, Ibaraki 305-8577 (Japan)

    2009-06-15

    Active particle control capabilities of a lithium-gettered rotating drum poloidal limiter have been demonstrated during 50 kW RF-current drive discharges in a compact spherical tokamak with the major and minor radii of 30 and 20 cm, respectively. The pulse length is typically approx300 ms with a flat-top of approx250 ms. The rotating limiter is in the shape of cylinder with the diameter and axial length of 15 and 12 cm, respectively. It has reproducibly been observed that, as soon as the rotating drum is gettered with lithium, hydrogen recycling measured with H{sub a}lpha spectroscopy decreases by a factor of approx3 not only near the limiter but also in the center stack region. Also, the oxygen impurity level measured with O-II spectroscopy is reduced by a factor of approx3. Meanwhile, the core electron temperature increases from around 7 eV to 20 eV along which the flat-top toroidal plasma current is found to nearly double even at the same vertical magnetic field. Comprehensive surface analysis has been conducted to investigate hydrogen and lithium distributions over the rotating drum after plasma exposure.

  17. The Underwater Recovery of Monumental Marble Column Drums from an Ancient Shipwreck at Kızılburun, Turkey

    Science.gov (United States)

    Carlson, Deborah N.

    2016-08-01

    In the first century B.C., a stone carrier sank off the Aegean coast of Turkey at Kızılburun transporting all the elements of a monumental marble column, including a single Doric capital and eight drums. The 60-tonne cargo lay at a depth of 45-48 m and was excavated in its entirety by the Institute of Nautical Archaeology at Texas A&M University between 2005 and 2011. Ongoing research has shown that the Doric column pieces in the Kızılburun cargo originated in the marble quarries on Proconnesus Island in the Sea of Marmara and were very likely heading for the Temple of Apollo at Claros when the ship sank just 50 km short of its destination. The complete recovery of the ship's cargo posed a unique set of methodological challenges involving lifting the multi-tonne marble drums without disturbing the delicate waterlogged wooden hull remains preserved beneath. This report summarizes the solutions developed over five seasons in order to rig, hoist, move, and ultimately raise to the surface eight large ancient marble column drums (as well as all the other marble artifacts in the cargo) from a depth of almost 50 m under water.

  18. Production of elemental sulfur and bentonite clay granules in a rotary drum

    Science.gov (United States)

    Hamilton, Ian Wallace

    Biological oxidation of sulfur granules is a critical component in elemental sulfur fertilizers since it converts sulfur to plant available sulfate. The level of biological oxidation is, in turn, regulated by the size and surface area of the sulfur granules. The aim of this research was to produce coarse sulfur granules that disintegrate to the correct particle size for biological oxidation, as well as the correct size for ballistic distribution from a spreader. Thus the interaction between mineral powders such as serpentine rock was investigated to get a better understanding of how these types of minerals react at different size fractions in granulation. Sulfur granules were developed from mixtures of 10% sodium bentonite clay with molten elemental sulfur. This was accomplished by sprayed a mixture bentonite and elemental sulfur into a falling curtain of fine material powder within a rotating drum. When comparing the seed materials, the serpentine rock showed sufficiently lower electrostatic build-up than phosphate rock. Serpentine rock also appears to help facilitate the disintegration of the granules when they are exposed to water. The outcome of the research was that it is possible to make a granulated sulfur fertilizer that had the correct size fraction and disintegration characteristics suitable for agronomic use.

  19. A perturbative approach to the spectral zeta functions of strings, drums, and quantum billiards

    Energy Technology Data Exchange (ETDEWEB)

    Amore, Paolo [Facultad de Ciencias, CUICBAS, Universidad de Colima, Bernal Diaz del Castillo 340, Colima, Colima (Mexico)

    2012-12-15

    We show that the spectral zeta functions of inhomogeneous strings and drums can be calculated using Rayleigh-Schroedinger perturbation theory. The inhomogeneities that can be treated with this method are small but otherwise arbitrary and include the previously studied case of a piecewise constant density. In two dimensions the method can be used to derive the spectral zeta function of a domain obtained from the small deformation of a square. We also obtain exact sum rules that are valid for arbitrary densities and that correspond to the values taken by the spectral zeta function at integer positive values; we have tested numerically these sum rules in specific examples. We show that the Dirichlet or Neumann Casimir energies of an inhomogeneous string, evaluated to first order in perturbation theory, contain in some cases an irremovable divergence, but that the combination of the two is always free of divergences. Finally, our calculation of the Casimir energies of a string with piecewise constant density and of two perfectly conducting concentric cylinders, of similar radius, reproduce the results previously published.

  20. Simultaneous Production of Amyloglucosidase and Exo-Polygalacturonase by Aspergillus niger in a Rotating Drum Reactor.

    Science.gov (United States)

    Colla, Eliane; Santos, Lucielen Oliveira; Deamici, Kricelle; Magagnin, Glênio; Vendruscolo, Mauricio; Costa, Jorge Alberto Vieira

    2017-02-01

    Simultaneous production of amyloglucosidase (AMG) and exo-polygalacturonase (exo-PG) was carried out by Aspergillus niger in substrate of defatted rice bran in a rotating drum bioreactor (RDB) and studied by a 3(1) × 2(2) factorial experimental design. Variables under study were A. niger strains (A. niger NRRL 3122 and A. niger t0005/007-2), types of inoculum (spore suspension and fermented bran), and types of inducer (starch, pectin, and a mix of both). Solid-state fermentation process (SSF) was conducted at 30 °C under 60-vvm aeration for 96 h in a pilot scale. Production of AMG and exo-PG was significantly affected by the fungal strain and the type of inoculum, but inducers did not trigger any significant effect, an evidence of the fact that these enzymes are constitutive. The maximum activity of exo-PG was 84 U gdm(-1) whereas the maximum yield of AMG was 886.25 U gdm(-1).

  1. Optimization test of the 2BSL-320 vegetable seeders with air-suction drum type

    Science.gov (United States)

    Tang, B.; Wang, Y. S.; Ji, S. Z.

    2017-07-01

    The seeding raising technology of the hole tray assembly line is an important part of modern agriculture. The 2BSL-320 vegetable seeders with air-suction drum type are implements that are used to fill nutritional soil and press a hole in a float tray to sow seeds precisely. It can complete the whole process of putting down the tray, bedding the soil, scraping the soil, pressing a hole, sowing the seeds, compacting the soil, watering and putting away the tray by one time. Based on the introduction of the structure and working principle of the implement’s critical components, in order to improve the seeding efficiency and the seeding accuracy of the seeders, the response surface tests and the group experiments were carried out in this paper. And the MATLAB tool box was used to conduct fitting and optimization analysis of the test results, also the rationality of the optimization results was validated by experiments, which had provided a theoretical basis for the design of operation parameters in the vegetable seeders and had improved the seeding efficiency and quality.

  2. Follow-up study of Evolution-drum chipper; Evolution-energiapuuhakkurin kaeyttoeselvitys

    Energy Technology Data Exchange (ETDEWEB)

    Lahti, P. [Kotimaiset Energiat Ky, Kangashaekki (Finland); Vesisenaho, T. [VTT Energy, Jyvaeskylae (Finland). Fuel Production

    1997-12-01

    The aim of this project was to test and further develop a new type of a drum chipper. It was assumed that this Evolution-chipper would be able to produce fuel chips without long splinters and would also be reliable and effective in chipping work at road-side landings. In this project the fuel chip quality and productivity of the chipper were found out. The follow-up study started in October 1995 and ended in the end of 1996. According to the follow-up study the mechanical availability of the chipper was 83 % during a period of one year. Because of the rather low level of fuel chip utilisation in Finland the work sites are located far from each other. Therefore the moving between working sites take as much as 1/5 of the total working hours. The chipper is easy to operate and the differences in the productivity between operators are modest. The chipping productivity varies mainly depending on the raw material. The average productivity was 45,8 m{sup 3} (loose) per gross effective hour during the follow-up period. The internal screening system of the chipper diminishes the amount of long splinters effectively. Other chipping parameters (such as rotating speed) affected the chip quality only a little. (orig.)

  3. Fractal zeta functions and fractal drums higher-dimensional theory of complex dimensions

    CERN Document Server

    Lapidus, Michel L; Žubrinić, Darko

    2017-01-01

    This monograph gives a state-of-the-art and accessible treatment of a new general higher-dimensional theory of complex dimensions, valid for arbitrary bounded subsets of Euclidean spaces, as well as for their natural generalization, relative fractal drums. It provides a significant extension of the existing theory of zeta functions for fractal strings to fractal sets and arbitrary bounded sets in Euclidean spaces of any dimension. Two new classes of fractal zeta functions are introduced, namely, the distance and tube zeta functions of bounded sets, and their key properties are investigated. The theory is developed step-by-step at a slow pace, and every step is well motivated by numerous examples, historical remarks and comments, relating the objects under investigation to other concepts. Special emphasis is placed on the study of complex dimensions of bounded sets and their connections with the notions of Minkowski content and Minkowski measurability, as well as on fractal tube formulas. It is shown for the f...

  4. High-speed measurement of axial grain transport in a rotating drum

    Science.gov (United States)

    van Bussel, Frank; Khan, Zeina; Schaber, Marc; Seemann, Ralf; Scheel, Mario; Dimichiel, Marco

    2012-02-01

    Over short timescales granular mixtures separate by size when tumbled in a partially filled horizontal drum. The smaller grains move toward the axis of rotation to form a central core; undulations in this core gradually increase in amplitude until they grow into axial bands. Using non-invasive high-speed synchrotron x-ray particle tracking, we investigate the axial transport properties of tracer particles traveling amongst glass spheres. This new technique allows us to gather data on time scales not previously possible. When the tracers are present in larger proportions the mixtures we used should have different tendencies to segregate axially according to size ratio; one of our findings, however, is that when the tracer concentration is low the single-particle dynamics of these mixtures do not depend on the relative particle sizes in any appreciable way. This implies that the potential for a mixture to axially segregate cannot be inferred from the microscopic dynamics of individual small particles. A second finding is that while the slope of the mean-squared displacement is close to that expected from diffusive transport, as determined from the single-particle dynamics, more detailed analyses indicate anomalous transport.

  5. Exploring shamanic journeying: repetitive drumming with shamanic instructions induces specific subjective experiences but no larger cortisol decrease than instrumental meditation music.

    Directory of Open Access Journals (Sweden)

    Bruno Gingras

    Full Text Available Exposure to repetitive drumming combined with instructions for shamanic journeying has been associated with physiological and therapeutic effects, such as an increase in salivary immunoglobulin A. In order to assess whether the combination of repetitive drumming and shamanic instructions is specifically associated with these effects, we compared the effect of listening to either repetitive drumming or instrumental meditation music for 15 minutes on salivary cortisol concentration and on self-reported physiological and psychological states. For each musical style, two groups of participants were exposed to two conditions: instructions for shamanic journeying or relaxation instructions. A total of 39 participants (24 females inexperienced in shamanic journeying completed the experiment. Salivary cortisol concentrations were measured before and after exposure to music. In addition, participants filled out a mood questionnaire before and after the experiment and completed a post experiment questionnaire on their experiences. A significant decrease in the concentration in salivary cortisol was observed across all musical styles and instructions, indicating that exposure to 15 minutes of either repetitive drumming or instrumental meditation music, while lying down, was sufficient to induce a decrease in cortisol levels. However, no differences were observed across conditions. Significant differences in reported emotional states and subjective experiences were observed between the groups. Notably, participants exposed to repetitive drumming combined with shamanic instructions reported experiencing heaviness, decreased heart rate, and dreamlike experiences significantly more often than participants exposed to repetitive drumming combined with relaxation instructions. Our findings suggest that the subjective effects specifically attributed to repetitive drumming and shamanic journeying may not be reflected in differential endocrine responses.

  6. Protein-protein interaction and pathway analyses of top schizophrenia genes reveal schizophrenia susceptibility genes converge on common molecular networks and enrichment of nucleosome (chromatin) assembly genes in schizophrenia susceptibility loci.

    Science.gov (United States)

    Luo, Xiongjian; Huang, Liang; Jia, Peilin; Li, Ming; Su, Bing; Zhao, Zhongming; Gan, Lin

    2014-01-01

    Recent genome-wide association studies have identified many promising schizophrenia candidate genes and demonstrated that common polygenic variation contributes to schizophrenia risk. However, whether these genes represent perturbations to a common but limited set of underlying molecular processes (pathways) that modulate risk to schizophrenia remains elusive, and it is not known whether these genes converge on common biological pathways (networks) or represent different pathways. In addition, the theoretical and genetic mechanisms underlying the strong genetic heterogeneity of schizophrenia remain largely unknown. Using 4 well-defined data sets that contain top schizophrenia susceptibility genes and applying protein-protein interaction (PPI) network analysis, we investigated the interactions among proteins encoded by top schizophrenia susceptibility genes. We found proteins encoded by top schizophrenia susceptibility genes formed a highly significant interconnected network, and, compared with random networks, these PPI networks are statistically highly significant for both direct connectivity and indirect connectivity. We further validated these results using empirical functional data (transcriptome data from a clinical sample). These highly significant findings indicate that top schizophrenia susceptibility genes encode proteins that significantly directly interacted and formed a densely interconnected network, suggesting perturbations of common underlying molecular processes or pathways that modulate risk to schizophrenia. Our findings that schizophrenia susceptibility genes encode a highly interconnected protein network may also provide a novel explanation for the observed genetic heterogeneity of schizophrenia, ie, mutation in any member of this molecular network will lead to same functional consequences that eventually contribute to risk of schizophrenia.

  7. Dynamics of an estuarine nursery ground: the spatio-temporal relationship between the river flow and the food web of the juvenile common sole ( Solea solea, L.) as revealed by stable isotopes analysis

    Science.gov (United States)

    Kostecki, C.; Le Loc'h, F.; Roussel, J.-M.; Desroy, N.; Huteau, D.; Riera, P.; Le Bris, H.; Le Pape, O.

    2010-07-01

    Estuaries are essential fish habitats because they provide nursery grounds for a number of marine species. Previous studies in the Bay of Vilaine (part of the Bay of Biscay, France) have underlined the estuarine dependence of juvenile common sole ( Solea solea, L.) and shown that the extent of sole nursery grounds was positively influenced by the variability of the river flow. In the present study, stable carbon and nitrogen isotopes were used to describe the trophic network until the young-of-the-year sole and to compare interannual variations in the dominant trophic pathways in the sole nursery areas in this bay. Particulate organic matter (POM), sediment organic matter (SOM), microphytobenthos, benthic invertebrate sole prey and young-of-the-year common sole were collected during the summer over 4 years characterised by contrasting river discharges. POM isotopic signatures were used to identify the origins of nutrient and organic matter assimilated into the estuarine food web through benthic organisms to juvenile common sole. Interannual spatial variations were found in the POM carbon stable isotope signatures, with the importance of these variations depending on the interannual fluctuations of the river flow. Moreover, the spatio-temporal variability of this POM isotopic signature was propagated along the food webs up to juvenile sole, confirming the central role of river discharge and terrigeneous subsidy input in the estuarine benthic food web in determining the size of the sole nursery habitat.

  8. OPTIMIZATION OF TRANSIEN PROCESSES OF WATER LEVEL VARIATION IN DRUM OF STEAM BOILERS

    Directory of Open Access Journals (Sweden)

    G. T. Kulakov

    2014-01-01

    Full Text Available The work of regulator in general three-impulse automatic control system of water level in drum of boiler doesn’t supply quality of internal and external disturbance attack (presentation of regulation mistakes. That is why it is needed to improve. Different methods of proportional plus reset controller regulation of three-phase automatic feed control system are considered. There were suggested new methods to improve the quality of regulation of water level in boilers. Here the step system of automatic regulation was determined, on the base of transfer function.It is noticed that optimal transient processes supply calculation of numerical value of transmission factor of regulator at g =2,618, it is more then was recommended, but statistic mistakes remain. The transient simulation method in fast-time scale is recommended, this allow to determine early the value of statistic mistake of regulation by disturbances of reheated steam consumption and properly change the task to compensating device of step automatic control system. And numerical value of time constant criteria  should be calculated on the base of numbers of golden section(Phi, taking into account the definite time constant of lead section and time-lag, time-lag on controlled influence channel, and also taking into account maximum value of controlled influence. This method allow to reduce in two times the total time of regulation, to decrease absolute mistake of regulation in three times, and maximum value of regulation influence by feedwater in 1,7 times.

  9. INVARIANT SYSTEM OF THE STEAM-DRUM BOILER FEED AUTOMATIC REGULATION

    Directory of Open Access Journals (Sweden)

    G. T. Kulakov

    2015-01-01

    Full Text Available The choice of the controlling system structure, law of control, and optimal parameters for the regulator dynamic settings exercise, under principal influences, substantial effect on quality of the transient processes of water-level change in the shell of the boiler. At the present moment, techniques of design by analysis for the optimal regulating systems allow improving quality of the transient processes. Applying the method of structural-parametrical optimization and the invariance theory render it possible to significantly improve quality of the boiler-shell water level maintaining by means of changing the system structure and optimizing the feed automatic-control system dynamic settings. However, this becomes attainable at the expense of increasing the control-action maximum magnitude with the feeding water rate. At the same time, the indicator of the latter should be less than the control-action value of the typical threeelement control of the feed-regulation system as this directly links to the boiler equipment safety, the drum metal and the feed-water economizer longevity. For removal of this shortcoming, the paper proposes to form in parallel to the real inertial region of the controlled member its dynamic simulation which allows separating the equivalent external disturbance without having to measure it. And to limit the compensation device output to the control-action value of the typical three-element control system of the automatic feed-regulation. This leads to the maximum control-action magnitude decrease, besides, the external-disturbances execution time remains unchanged. Altogether, under all the influences, the authors report of receiving substantial improvement of regulation quality as compared with the typical three-element automatic feed-regulation system

  10. Numerical simulation for volatile organic compound removal in rotating drum biofilter

    Institute of Scientific and Technical Information of China (English)

    CHEN Hong; YANG ChunPing; ZENG GuangMing; YU KongLiang; QU Wei; YU GuanLong; MENG Lei

    2007-01-01

    Rotating drum biofilters (RDBs) could effectively remove volatile organic compounds (VOCs) from waste gas streams.A mathematical model was developed on the basis of mass transport and mass balance equations in an RDB, the two-film theory, and the Monod kinetics.This model took account of mass transfer and biodegradation of VOC in the gas-water-biofilm three-phase system in the biofilter, and could simulate variations of VOC removal efficiency with a changing specific surface area and porosity of the media due to the increasing of biofilm thickness in the biofilter.Toluene was used as a model VOC.This model was further simplified by introducing a coefficient of the gas velocity and neglecting the water phase due to the complexity of operating conditions.The equations for the biofilm phase, gas phase, and biofilm accumulation in this model were solved using collocation method, analytic method, and the Runge-Kutta method separately.A computer program was written down as MATLAB to solve this model.Results of numerical solutions showed that toluene removal efficiency in the RDB increased and reached the maximum values of 97% on day 4 after the startup, and then decreased and remained at 90% after 5 more days of operation.Toluene concentration was high at the outermost layer where more than 70% toluene was removed, and was low at the innermost layer where less than 10% toluene was removed.The dynamic removal efficiencies from this model correlated reasonably well with experimental results for toluene removal in a multi-layered RDB.

  11. Development of a feeder device for logging residue for a drum chipper; Hakkurin syoetoen kehittaeminen energiapuulle

    Energy Technology Data Exchange (ETDEWEB)

    Leinonen, T.; Kemppainen, J.P. [Oulu Univ. (Finland). Dept. of Mechanical Engineering

    1997-12-01

    The aim of this project is to increase the productivity of a large drum chipper by developing a feeder device to be used especially when chipping logging residue. Logging residue from regeneration areas is the most important reserve of forest biomass for the production of renewable energy in Finland. It is possible ecologically and economically to use about 5 million m{sup 3} of logging residue yearly for energy purposes. Currently both large lorry based chippers and smaller forwarder based chippers are used for chipping logging residue. However even the latest versions of these chippers are not well equipped for chipping logging residue. The ball like shape of residue piles causes blockades, if too large amounts of residue are fed into the chipper. Keeping the material flow even is difficult. In this project a prototype of a feeder device will be designed and manufactured to exactly find out the problems, that occur when feeding logging residue to a chipper. The designed prototype is based on a tubular chassis, which supports a conveyor made of steel plates. Prototype also has a 2,5 m wide feeding table and a feeder roll, which is located above the conveyor just before the chipper opening. Both the conveyor and the feeder roll are powered by hydraulic motors. The maximum feeding force is 20 kN. For research purposes both hydraulic pressure and flow can be adjusted individually for both motors. During 1996 activities included designing and building the prototype feeder device. In 1997 the prototype will be tested to find out possible problems, which need to be cured. After problems are solved and other improvements are made, the feeder device will be installed to an existing chipper and then tested again to determine the productivity of the new feeder device compared to the old unit. (orig.)

  12. Case study of 85 m{sup 3} floating drum biogas plant under hilly conditions

    Energy Technology Data Exchange (ETDEWEB)

    Kalia, A.K.; Singh, S.P. [HPKV, Palampur (India). Dept. of Agricultural Engineering

    1999-05-01

    An 85 m{sup 3} floating drum biogas plant was installed at the dairy farm of HP Agricultural University, Palampur, in 1989 to meet the energy needs of cooking food in the veterinary hostel mess and for general dairy requirements. It cost nearly Rs. 0.21 million (US dollars 6293), including the cost of an 800 m gas pipe line, and is working satisfactorily without any major problems except breakage of the central guide of its gas holder. With the feed rate of 17 q cattle dung/day, 50 m{sup 3} and 30 m{sup 3} biogas was obtained in the summer and winter months, respectively, during 1989-1991. The reduction of feed rate to 9 q cattle dung/day in 1992 onwards resulted in lowering the gas production of 25 m{sup 3} and 18 m{sup 3} in the summer and winter months, respectively. This gas was just sufficient to meet 73% (9466 MJ/month) and 53% (7019 MJ/month) of the energy needs for cooking meals in the hostel alone in the summer and winter months, respectively, during the course of the study. Considering the biogas and manure obtained from the plant, the income-cost ratios during the period 1989-1991 and 1992-1997 were found to be 1.44 and 1.15, respectively, suggesting that, though the plant was under fed relatively to the requisite feed rate (21 q cattle dung/day), the installation of this plant was an economically viable proposition. (author)

  13. Performance of rotating drum biofilter for volatile organic compound removal at high organic loading rates

    Institute of Scientific and Technical Information of China (English)

    YANG Chunping; CHEN Hong; ZENG Guangming; ZHU Xueqing; SUIDAN Makram T

    2008-01-01

    Uneven distribution of volatile organic compounds (VOCs) and biomass,and excess biomass accumulation in some biofilters hinder the application of biofiltration technology.An innovative multilayer rotating drum biofilter (RDB) was developed to correct these problems.The RDB was operated at an empty bed contact time (EBCT) of 30 s and a rotational rate of 1.0 r/rain.Diethyl ether was chosen as the model VOC.Performance of the RDB was evaluated at organic loading rates of 32.1,64.2,128,and 256 g ether/(m3·h) (16.06 g ether/(m3·h) ≈1.0 kg chemical oxygen demand (COD)/(m3·d)).The EBCT and organic loading rates were recorded on the basis of the medium volume.Results show that the ether removal efficiency decreased with an increased VOC loading rate.Ether removal efficiencies exceeding 99% were achieved without biomass control even at a high VOC loading rate of 128 g ether/(m3·h). However,when the VOC loading rate was increased to 256 g ether/(m3·h),the average removal efficiency dropped to 43%.Nutrient limitation possibly contributed to the drop in ether removal efficiency.High biomass accumulation rate was also observed in the medium at the two higher ether loading rates,and removal of the excess biomass in the media was necessary to maintain stable performance. This work showed that the RDB is effective in the removal of diethyl ether from waste gas streams even at high organic loading rates. The results might help establish criteria for designing and operating RDBs.

  14. Comparison of Fenton's reagent and adsorption for treatment of industrial container and drum cleaning industry wastewater.

    Science.gov (United States)

    Güneş, Elçin; Çifçi, Deniz İzlen; Çelik, Suna Özden

    2017-03-27

    The present study is aimed to explore the characterization of Industrial Container and Drum Cleaning (ICDC) industry wastewater and treatment alternatives of this wastewater using Fenton and adsorption processes. Wastewater derived from ICDC industry is usually treated by chemical coagulation and biological treatment in Turkey and then discharged in a centralized wastewater treatment facility. It is required that the wastewater COD is below 1500 mg/L to treat in a centralized wastewater treatment facility The wastewater samples characterized for parameters of pH, conductivity, COD, BOD5, TSS, NH3-N, TN, TOC, TP, Cd, Cr, Cu, Fe, Ni, Pb, Zn, Hg. Optimum conditions of adsorption and Fenton processes have been assessed in terms of COD removal. Initial COD values were quite high in the three of samples and were in the range of 11300-14200 mg/L. The optimum conditions were as follows for Fenton treatment; 35-40 g/L for H2O2, 2-5 g/L for Fe(2+) and 13-36 for H2O2/Fe(2+) molar ratio. The optimum conditions of PAC doses and contact times in adsorption studies were 20-30 g/L and 5-12 hours respectively. In terms of COD removal, the efficiency of the Fenton process was found to be about 91-97%, and the efficiency of the adsorption process was found to be 88-98%. COD, BOD5, TOC, TP, Cd, Cr, Cu, Fe, Ni, Pb, Zn and Hg removal efficiencies were compared for both Fenton and adsorption processes under optimum conditions for the three samples. The results suggest that these wastewaters are suitable for discharge to a centralized wastewater treatment plant.

  15. On the Historical Relationship between the Drum and Wushu%鼓与武术套路渊源关系的思考

    Institute of Scientific and Technical Information of China (English)

    杨广艳; 曹红敏

    2014-01-01

    运用文献资料法对武术套路与鼓之间的渊源关系进行了研究梳理,认为鼓与武术套路都源于原始巫术。鼓由于原始巫术行巫的需要成为神器,而武术套路又衍生于模仿巫术,正因为二者的同源关系,武术套路与鼓之间产生了密不可分的关系,也正因此在武术的发展历史过程中始终有鼓相伴,尤其是在武术套路演练、表演时必有鼓与之相配。%The relationship between Wushu and the drum is studied by using the method of literature research. It is considered drum and martial arts are derived from the original witchcraft. Drum becomes artifact due to the primitive witchcraft witch and martial arts are derived from imitation of sorcery. Because of the homologous relationship between the two, in the developmental history of martial arts, is always accompanied by drums. Especially in Wushu training and performance, drum is always with it.

  16. Quarter-scale modeling of room convergence effects on CH (contact-handled) TRU drum waste emplacements using WIPP (Waste Isolation Pilot Plant) reference design geometries

    Energy Technology Data Exchange (ETDEWEB)

    VandeKraats, J.

    1987-11-01

    This study investigates the effect of horizontal room convergence on CH waste packages emplaced in the WIPP Reference Design geometry (rooms 13 feet high by 33 feet wide, with minus 3/8 inch screened backfill emplaced over and around the waste packages) as a function of time. Based on two tests, predictions were made with regard to full-scale 6-packs emplaced in the Reference Design geometry. These are that load will be transmitted completely through the stack within the first five years after waste emplacement and all drums in all 6-packs will be affected; that virtually all drums will show some deformation eight years after emplacement; that some drums may breach before the eighth year after emplacement has elapsed; and that based on criteria developed during testing, it is predicted that 1% of the drums emplaced will be breached after 8 years and, after 15 years, approximately 12% of the drums are predicted to be breached. 8 refs., 41 figs., 3 tabs.

  17. Determination of activity by gamma spectrometry of radionuclides present in drums of residues generated in nuclear centrals; Determinacion de actividad por espectrometria gamma de radionucleidos presentes en tambores de residuos generados en centrales nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Aguiar, J.C.; Fernandez, J. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250, Ciudad Autonoma de Buenos Aires (Argentina)]. e-mail: jaguiar@cae.arn.gov.ar

    2006-07-01

    The generation of radioactive residuals in nuclear centrals as CNA I (Atucha I Nuclear Central) and CNE (Embalse Nuclear Central) makes that the measurement of those radionuclides has been a previous stage to the waste management. A method used in those nuclear centrals it is the gamma spectrometry with HPGe detectors, previous to the immobilization of the residual in a cemented matrix, with this the contact with the external agents and its possible dispersion to the atmosphere in the short term is avoided. The ARN (Nuclear Regulatory Authority) of Argentina it carries out periodically intercomparisons and evaluations of the measurement and procedures systems used in the nuclear power stations for the correct measurement and determination of activity of radioactive residuals by gamma spectrometry. In this work an independent method of measurement is exposed to the nuclear power stations. To determine the activity of the residuals by gamma spectrometry deposited in drums, it is required of the precise knowledge of the efficiency curve for such geometry and matrix. Due to the RNA doesn't have a pattern of these characteristics, a mathematical model has been used to obtain this efficiency curve. For it, it is necessary to determine previously: 1) the geometric efficiency or solid angle sustained by the source-detector system (drum-detector) applying a mathematical model described in this work. 2) To estimate the auto-attenuation factor that present the photons in the cemented matrix, these calculations are carried out with a simple equation and its are verified with the Micro Shield 6.10 program. The container commonly used by these nuclear power stations its are drums for 220 liters constructed with SAE 1010 steel and with a thickness of 0.127 cm, with an approximate weight 7.73 Kg., internal diameter of 57.1 cm, and height: 87 cm. The results obtained until the moment register a discrepancy from 5 to 10% with relationship to the measurements carried out by the

  18. On-Line Condition Monitoring System for High Level Trip Water in Steam Boiler’s Drum

    Directory of Open Access Journals (Sweden)

    Ismail Alnaimi Firas B.

    2014-07-01

    Full Text Available This paper presents a monitoring technique using Artificial Neural Networks (ANN with four different training algorithms for high level water in steam boiler’s drum. Four Back-Propagations neural networks multidimensional minimization algorithms have been utilized. Real time data were recorded from power plant located in Malaysia. The developed relevant variables were selected based on a combination of theory, experience and execution phases of the model. The Root Mean Square (RMS Error has been used to compare the results of one and two hidden layer (1HL, (2HL ANN structures

  19. Design and dynamic simulation for the transmission mechanism of drum-shaped gear with ring-involute teeth

    Institute of Scientific and Technical Information of China (English)

    LI Qing-kai; LI Xiao-fang; ZHAO Yong-qiang

    2007-01-01

    The new mechanism of drum-shaped gear with ring-involute teeth is presented to implement dimensional transmission for the stairlift. The structure of the gear and rack in this actuating mechanism is designed,and then its inherent radius of turn and modulus selection have been studied. In order to make the mechanism move steadily, the drive guide is proposed. After using the dynamics simulation software ADAMS to analyze the 3D model, this kind of mechanism is confirmed to be able to implement dimensional track. The useful method and basis would be provided for the optimization design of the mechanism.

  20. Non-linear 2-DOF model and centre manifold theory to study limit cycle oscillations caused by drum-brake judder

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ming-gang; HUANG Qi-bai; WANG Yong; XU Zhi-sheng

    2007-01-01

    This paper presents the research on the laws of systematic-parameter dependent variation in the vibration amplitude of drum-brake limit cycle oscillations (LCO). We established a two-degree non-linear dynamic model to describe the low-frequency vibration of the drum brake, applied the centre manifold theory to simplify the system, and obtained the LCO amplitude by calculating the normal form of the simplified system at the Hopf bifurcation point. It is indicated that when the friction coefficient is smaller than the friction coefficient at the bifurcation point, the amplitude decreases; whereas with a friction coefficient larger than the friction coefficient of bifurcation point, LCO occurs. The results suggest that it is applicable to suppress the LCO amplitude by changing systematic parameters, and thus improve the safety and ride comfort when applying brake. These findings can be applied to guiding the design of drum brakes.

  1. Gap-PCR Screening for Common Large Deletional Mutations of β-Globin Gene Cluster Revealed a Higher Prevalence of the Turkish Inversion/Deletion (δβ0 Mutation in Antalya

    Directory of Open Access Journals (Sweden)

    Türker Bilgen

    2016-05-01

    Full Text Available Objective: Although the calculated carrier frequency for point mutations of the β-globin gene is around 10% for Antalya Province, nothing is known about the profile of large deletional mutations involving the β-globin gene. In this study, we aimed to screen common deletional mutations in the β-globin gene cluster in patients for whom direct DNA sequencing was not able to demonstrate the mutation(s responsible for the disease phenotype. Materials and Methods: Thirty-one index cases selected with a series of selection events among 60 cases without detected β-globin gene mutation from 580 thalassemia-related cases tested by direct sequencing over the last 4 years in our diagnostic center were screened for the most common 8 different large deletional mutations of the β-globin gene cluster by gap-PCR. Results: We detected 1 homozygous and 9 heterozygous novel unrelated cases for the Turkish inversion/deletion (δβ0 mutation in our series of 31 cases. Our study showed that the Turkish inversion/ deletion (δβ0 mutation per se accounts for 16.6% of the unidentified causative alleles and also accounts for 1.5% of all detected mutations over the last 4 years in our laboratory. Conclusion: Since molecular diagnosis of deletional mutations in the β-globin gene cluster warrants different approaches, it deserves special attention in order to provide prenatal diagnosis and prevention opportunities to the families involved. We conclude that the Turkish inversion/deletion (δβ0, as the most prevalent deletional mutation detected so far, has to be routinely tested for in Antalya, and the gapPCR approach has valuable diagnostic potential in the patients at risk.

  2. THE APPLICATION OF ASC-ANALYSIS TO DETERMINE RATIONAL DESIGN FEATURES AND PARAMETERS OF THE MODES RELATIVE TO THE SCREW DRUMS FOR MIXING ANIMAL FEED

    Directory of Open Access Journals (Sweden)

    Marchenko A. Y.

    2016-06-01

    Full Text Available The authors have developed and manufactured a large number of different designs of relative helical drums for mixing animal feed. We have conducted 749 field experiments with the drums of the 10 different designs with different parameters modes of operation. In all experiments, we measured the quality of the feed mixture. However, directly based on empirical data, rational choice of design features and parameters of the operation modes of the reels is not possible. For this, you must first develop a model reflecting these empirical data. The construction of meaningful analytical models of different types of drums is a difficult and demanding scientific task, the complexity of which is due to the large variety and complexity of forms of drums and their mode of usage, a large number of diverse physical factors affecting the processes in the drum. As a consequence, the development of analytical models associated with a large number of simplifying assumptions that reduce their versatility and reliability. Therefore, it is important to search of a mathematical method and software tools provide a quick and simple for the user to identify and influence the design of the drum and the parameters of the operating modes on the quality of the feed mixture directly on the basis of empirical (experimental data. The work proposes a solution to this problem with the use of a new universal innovative method of artificial intelligence: automated system-cognitive analysis (ASC-analysis and its programmatic Toolkit – universal cognitive analytical system called "Eidos". In the system of "Eidos" we have implemented a software interface that provides direct input into the system large amounts of empirical data from Excel file. Created on their basis in the system of "Eidos" system-cognitive model allows the visual form to reflect the effect of the structure of the drum and the parameters of the operating modes on the quality of the resulting feed mixture and to

  3. Assessing reproductive behavior important to fisheries management: a case study with red drum, Sciaenops ocellatus.

    Science.gov (United States)

    Lowerre-barbieri, Susan K; Burnsed, Sarah L Walters; Bickford, Joel W

    2016-06-01

    Spawning site selection and reproductive timing affect stock productivity and structure in marine fishes but are poorly understood. Traditionally, stock assessments measure reproductive potential as spawning stock biomass or egg production and do not include other aspects of reproductive behavior. Red drum make an excellent case study to assess these other aspects, as (1) they are highly fecund, pelagic spawners, like most exploited marine fishes; (2) their life cycle is delineated between nursery (estuarine) and adult (coastal and offshore) habitat; and (3) they are managed at these two spatial scales. This study was conducted from August 2012 to December 2013 and integrates data from multiple methods and spatial scales. Aerial surveys were used for large-scale monitoring of aggregations off two known estuarine nursery areas, Tampa Bay and Charlotte Harbor, Florida, USA. Capture-based sampling in Tampa Bay coastal (n = 2581) and estuarine waters (n = 158) was used to assess reproductive state and to confirm coastal spawning. To assess spatial dynamics, we acoustically tagged two population components in the Tampa Bay system, subadults from the estuary (n = 20) and adults from the coastal spawning site (n = 60). Behavioral plasticity was seen in subadult recruitment to coastal habitat, with some subadults maturing and recruiting before or during the spawning season and others (14 of 20 acoustically tagged fish) recruiting at the end of the 2012 spawning season. Both adults and recruited subadults (n = 29) were consequently detected in the Charlotte Harbor array, 132 km to the south. Spawning-site fidelity to the Tampa Bay spawning site occurred at both the population and individual scales. Aggregations consistently occurred in Tampa Bay coastal waters during the spawning season, and approximately two-thirds of tagged adults returned in the 2013 spawning season. A similar proportion of subadults returned to the Tampa Bay spawning site, exhibiting natal homing

  4. The analysis of core and symbiotic genes of rhizobia nodulating Vicia from different continents reveals their common phylogenetic origin and suggests the distribution of Rhizobium leguminosarum strains together with Vicia seeds.

    Science.gov (United States)

    Alvarez-Martínez, Estela R; Valverde, Angel; Ramírez-Bahena, Martha Helena; García-Fraile, Paula; Tejedor, Carmen; Mateos, Pedro F; Santillana, Nery; Zúñiga, Doris; Peix, Alvaro; Velázquez, Encarna

    2009-08-01

    In this work, we analysed the core and symbiotic genes of rhizobial strains isolated from Vicia sativa in three soils from the Northwest of Spain, and compared them with other Vicia endosymbionts isolated in other geographical locations. The analysis of rrs, recA and atpD genes and 16S-23S rRNA intergenic spacer showed that the Spanish strains nodulating V. sativa are phylogenetically close to those isolated from V. sativa and V. faba in different European, American and Asian countries forming a group related to Rhizobium leguminosarum. The analysis of the nodC gene of strains nodulating V. sativa and V. faba in different continents showed they belong to a phylogenetically compact group indicating that these legumes are restrictive hosts. The results of the nodC gene analysis allow the delineation of the biovar viciae showing a common phylogenetic origin of V. sativa and V. faba endosymbionts in several continents. Since these two legume species are indigenous from Europe, our results suggest a world distribution of strains from R. leguminosarum together with the V. sativa and V. faba seeds and a close coevolution among chromosome, symbiotic genes and legume host in this Rhizobium-Vicia symbiosis.

  5. Preliminary report of the comparison of multiple non-destructive assay techniques on LANL Plutonium Facility waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Bonner, C.; Schanfein, M.; Estep, R. [and others

    1999-03-01

    Prior to disposal, nuclear waste must be accurately characterized to identify and quantify the radioactive content. The DOE Complex faces the daunting task of measuring nuclear material with both a wide range of masses and matrices. Similarly daunting can be the selection of a non-destructive assay (NDA) technique(s) to efficiently perform the quantitative assay over the entire waste population. In fulfilling its role of a DOE Defense Programs nuclear User Facility/Technology Development Center, the Los Alamos National Laboratory Plutonium Facility recently tested three commercially built and owned, mobile nondestructive assay (NDA) systems with special nuclear materials (SNM). Two independent commercial companies financed the testing of their three mobile NDA systems at the site. Contained within a single trailer is Canberra Industries segmented gamma scanner/waste assay system (SGS/WAS) and neutron waste drum assay system (WDAS). The third system is a BNFL Instruments Inc. (formerly known as Pajarito Scientific Corporation) differential die-away imaging passive/active neutron (IPAN) counter. In an effort to increase the value of this comparison, additional NDA techniques at LANL were also used to measure these same drums. These are comprised of three tomographic gamma scanners (one mobile unit and two stationary) and one developmental differential die-away system. Although not certified standards, the authors hope that such a comparison will provide valuable data for those considering these different NDA techniques to measure their waste as well as the developers of the techniques.

  6. Process Knowledge Summary Report for Advanced Test Reactor Complex Contact-Handled Transuranic Waste Drum TRA010029

    Energy Technology Data Exchange (ETDEWEB)

    B. R. Adams; R. P. Grant; P. R. Smith; J. L. Weisgerber

    2013-09-01

    This Process Knowledge Summary Report summarizes information collected to satisfy the transportation and waste acceptance requirements for the transfer of one drum containing contact-handled transuranic (TRU) actinide standards generated by the Idaho National Laboratory at the Advanced Test Reactor (ATR) Complex to the Advanced Mixed Waste Treatment Project (AMWTP) for storage and subsequent shipment to the Waste Isolation Pilot Plant for final disposal. The drum (i.e., Integrated Waste Tracking System Bar Code Number TRA010029) is currently stored at the Materials and Fuels Complex. The information collected includes documentation that addresses the requirements for AMWTP and applicable sections of their Resource Conservation and Recovery Act permits for receipt and disposal of this TRU waste generated from ATR. This Process Knowledge Summary Report includes information regarding, but not limited to, the generation process, the physical form, radiological characteristics, and chemical contaminants of the TRU waste, prohibited items, and packaging configuration. This report, along with the referenced supporting documents, will create a defensible and auditable record for this TRU waste originating from ATR.

  7. Development of chain limbing and small-drum barking equipment; Ketjukarsinta- ja pienrumpukuorintaan perustuvan laitteiston kehittaeminen tuotantovalmiiksi

    Energy Technology Data Exchange (ETDEWEB)

    Rieppo, K. [Metsaeteho Oy, Helsinki (Finland); Hakkila, P.; Kalaja, H. [Finnish Forest Research Inst., Vantaa (Finland)

    1997-12-01

    Three test series were carried out in 1996 at the chain limbing- drum barking station developed by Pertti Szepaniak Oy. The test equipment was developed during the test series. During the first experiment in February the wood used was frozen. In this test series the whipping efficiency was insignificant and consequently, the bark contents remained too large. In the second test in September the whipping efficiency was too high and was not easy to adjust, and as a consequence the wood loss was unreasonable. In the third test in November, when the wood was not yet frozen, the whipping efficiency was correct and promising results were obtained both with regard to the bark content and wood loss. Limbed pine pulpwood was used as raw material. The bark contents of the chips ranged from 0.2 to 0.4 % and the wood loss in barking from 2.8 to 3.6 %. The productivity also improved clearly during the tests. The experiments indicated that a separate station based on a combination of chain limbing- barking and drum-barking is able to produce high-grade pulp chips both from limbed and non-limbed first-thinning pine wood. (orig.)

  8. Assessment of radiographic screen-film systems: a comparison between the use of a microdensitometer and a drum film digitiser.

    Science.gov (United States)

    Verdun, F R; Pachoud, M; Bergmann, D; Buhr, E

    2005-01-01

    A high-end drum film digitiser (Tango, Germany) and a calibrated linear microdensitometer developed by PTB were used to assess the modulation transfer function (MTF) and the noise power spectra (NPS) of 3 mammographic screen film systems at optical density levels of 0.8, 1.5 and 2.5. The use of a drum scanner to assess MTF and NPS data appears to be adequate but requires an appropriate characterisation of the scanner to verify its internal noise level and its MTF. It is further necessary to calibrate the scanner output in terms of visual diffuse optical densities. Processing of two-dimensional digital data of grating images need to be more strictly defined for accurate MTF measurements of screen-film systems. Nevertheless, even now it seems to be feasible to use commercially available high-end and well calibrated scanners to assess screen film systems. This is especially important for quality assurance purposes because important parameters of screen film systems such like MTF and NPS can now be determined without using sophisticated microdensitometers which are not commercially available.

  9. Analysis of Failure Causes and the Criticality Degree of Elements of Motor Vehicle’s Drum Brakes

    Directory of Open Access Journals (Sweden)

    D. Ćatić

    2014-09-01

    Full Text Available The introduction of the paper gives the basic concepts, historical development of methods of Fault Tree Analysis - FTA and Failure Modes, Effects and Criticality Analysis - FMECA for analysis of the reliability and safety of technical systems and importance of applying this method is highlighted. Failure analysis is particularly important for systems whose failures lead to the endangerment of people safety, such as, for example, the braking system of motor vehicles. For the failure analysis of the considered device, it is necessary to know the structure, functioning, working conditions and all factors that have a greater or less influence on its reliability. By formation of the fault tree of drum brakes in braking systems of commercial vehicles, it was established a causal relation between the different events that lead to a reduction in performance or complete failure of the braking system. Based on data from exploitation, using FMECA methods, determination of the criticality degree of drum brake’s elements on the reliable and safe operation of the braking system is performed.

  10. The design of a high-efficiency neutron counter for waste drums to provide optimized sensitivity for plutonium assay

    Energy Technology Data Exchange (ETDEWEB)

    Menlove, H.O.; Beddingfield, D.H.; Pickrell, M.M. [Los Alamos National Lab., NM (United States)] [and others

    1997-11-01

    An advanced passive neutron counter has been designed to improve the accuracy and sensitivity for the nondestructive assay of plutonium in scrap and waste containers. The High-Efficiency Neutron Counter (HENC) was developed under a Cooperative Research Development Agreement between the Los Alamos National Laboratory and Canberra Industries. The primary goal of the development was to produce a passive assay system for 200-L drums that has detectability limits and multiplicity counting features that are superior to previous systems. A detectability limit figure of merit (FOM) was defined that included the detector efficiency, the neutron die-away time, and the detector`s active volume and density that determine the cosmic-ray background. Monte Carlo neutron calculations were performed to determine the parameters to provide an optimum FOM. The system includes the {sup 252}Cf {open_quotes}add-a-source{close_quotes} feature to improve the accuracy as well as statistical filters to reduce the cosmic-ray spallation neutron background. The final decision gave an efficiency of 32% for plutonium with a detector {sup 3}He tube volume that is significantly smaller than for previous high-efficiency systems for 200-L drums. Because of the high efficiency of the HENC, we have incorporated neutron multiplicity counting for matrix corrections for those cases where the plutonium is localized in nonuniform hydrogenous materials. The paper describes the design and performance testing of the advanced system. 5 refs., 8 figs., 3 tabs.

  11. Characterization of metal-responsive transcription factor (MTF-1) from the giant rodent capybara reveals features in common with human as well as with small rodents (mouse, rat). Short communication.

    Science.gov (United States)

    Lindert, Uschi; Leuzinger, Lucas; Steiner, Kurt; Georgiev, Oleg; Schaffner, Walter

    2008-08-01

    From mammals to insects, metal-responsive transcription factor 1 (MTF-1) is essential for the activation of metallothionein genes upon heavy-metal load. We have previously found that human MTF-1 induces a stronger metal response than mouse MTF-1. The latter differs from the human one in a number of amino acid positions and is also shorter by 78 aa at its C-terminus. We reasoned that the weaker metal inducibility might be associated with a lesser demand for tight metal homeostasis in a low-weight, short-lived animal, and thus set out to determine the sequence of MTF-1 from the largest living rodent, the Brazilian capybara that can reach 65 kg and also has a considerably longer life span than smaller rodents. An expression clone for capybara MTF-1 was then tested for its activity in both mouse and human cells. Our analysis revealed three unexpected features: i) capybara MTF-1 in terms of amino acid sequence is much more closely related to human than to mouse MTF-1, suggesting an accelerated evolution of MTF-1 in the evolutionary branch leading to small rodents; ii) capybara MTF-1 is even 32 aa shorter at its C-terminus than mouse MTF-1, and iii) in an activity test, it is not more active than mouse MTF-1. The latter two findings might indicate that capybara has evolved in an environment with low heavy-metal load.

  12. Genetic and comparative genomics mapping reveals that a powdery mildew resistance gene Ml3D232 originating from wild emmer co-segregates with an NBS-LRR analog in common wheat (Triticum aestivum L.).

    Science.gov (United States)

    Zhang, Hongtao; Guan, Haiying; Li, Jingting; Zhu, Jie; Xie, Chaojie; Zhou, Yilin; Duan, Xiayu; Yang, Tsomin; Sun, Qixin; Liu, Zhiyong

    2010-11-01

    Powdery mildew caused by Blumeria graminis f. sp. tritici is one of the most important wheat diseases worldwide and breeding for resistance using diversified disease resistance genes is the most promising approach to prevent outbreaks of powdery mildew. A powdery mildew resistance gene, originating from wild emmer wheat (Triticum turgidum var. dicoccoides) accessions collected from Israel, has been transferred into the hexaploid wheat line 3D232 through crossing and backcrossing. Inoculation results with 21 B. graminis f. sp. tritici races indicated that 3D232 is resistant to all of the powdery mildew isolates tested. Genetic analyses of 3D232 using an F(2) segregating population and F(3) families indicated that a single dominant gene, Ml3D232, confers resistance in the host seedling stage. By applying molecular markers and bulked segregant analysis (BSA), we have identified polymorphic simple sequence repeats (SSR), expressed sequence tags (EST) and derived sequence tagged site (STS) markers to determine that the Ml3D232 is located on chromosome 5BL bin 0.59-0.76. Comparative genetic analyses using mapped EST markers and genome sequences of rice and Brachypodium established co-linearity of the Ml3D232 genomic region with a 1.4 Mb genomic region on Brachypodium distachyon chromosome 4, and a 1.2 Mb contig located on the Oryza sativa chromosome 9. Our comparative approach enabled us to develop new EST-STS markers and to delimit the genomic region carrying Ml3D232 to a 0.8 cM segment that is collinear with a 558 kb region on B. distachyon. Eight EST markers, including an NBS-LRR analog, co-segregated with Ml3D232 to provide a target site for fine genetic mapping, chromosome landing and map-based cloning of the powdery mildew resistance gene. This newly developed common wheat germplasm provides broad-spectrum resistance to powdery mildew and a valuable resource for wheat breeding programs.

  13. Genomic Analyses of Dominant U.S. Clonal Lineages of Phytophthora infestans Reveals a Shared Common Ancestry for Clonal Lineages US11 and US18 and a Lack of Recently Shared Ancestry Among All Other U.S. Lineages.

    Science.gov (United States)

    Knaus, B J; Tabima, J F; Davis, C E; Judelson, H S; Grünwald, N J

    2016-11-01

    Populations of the potato and tomato late-blight pathogen Phytophthora infestans are well known for emerging as novel clonal lineages. These successions of dominant clones have historically been named US1 through US24, in order of appearance, since their first characterization using molecular markers. Hypothetically, these lineages can emerge through divergence from other U.S. lineages, recombination among lineages, or as novel, independent lineages originating outside the United States. We tested for the presence of phylogenetic relationships among U.S. lineages using a population of 31 whole-genome sequences, including dominant U.S. clonal lineages as well as available samples from global populations. We analyzed ancestry of the whole mitochondrial genome and samples of nuclear loci, including supercontigs 1.1 and 1.5 as well as several previously characterized coding regions. We found support for a shared ancestry among lineages US11 and US18 from the mitochondrial genome as well as from one nuclear haplotype on each supercontig analyzed. The other nuclear haplotype from each sample assorted independently, indicating an independent ancestry. We found no support for emergence of any other of the U.S. lineages from a common ancestor shared with the other U.S. lineages. Each of the U.S. clonal lineages fit a model where populations of new clonal lineages emerge via migration from a source population that is sexual in nature and potentially located in central Mexico or elsewhere. This work provides novel insights into patterns of emergence of clonal lineages in plant pathogen genomes.

  14. Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins.

    Science.gov (United States)

    Baker, Heather M; Basu, Indira; Chung, Matthew C; Caradoc-Davies, Tom; Fraser, John D; Baker, Edward N

    2007-12-14

    Staphylococcus aureus is a significant human pathogen. Among its large repertoire of secreted toxins is a group of staphylococcal superantigen-like proteins (SSLs). These are homologous to superantigens but do not have the same activity. SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner. Co-crystallization of SSL5 with the tetrasaccharide sialyl Lewis X (sLe(X)), a key determinant of PSGL-1 binding to P-selectin, led to crystal structures of the SSL5-sLe(X) complex at resolutions of 1.65 and 2.75 A for crystals at two pH values. In both structures, sLe(X) bound to a specific site on the surface of the C-terminal domain of SSL5 in a conformation identical with that bound by P-selectin. Conservation of the key carbohydrate binding residues indicates that this ability to bind human glycans is shared by a substantial subgroup of the SSLs, including SSL2, SSL3, SSL4, SSL5, SSL6, and SSL11. This indicates that the ability to target human glycans is an important property of this group of toxins. Structural comparisons also showed that the Sia binding site in SSL5 contains a substructure that is shared by other Sia binding proteins from bacteria as well as viruses and represents a common binding motif.

  15. Crystal Structures of the Staphylococcal Toxin SSL5 in Complex With Sialyl-Lewis X Reveal a Conserved Binding Site That Shares Common Features With Viral And Bacterial Sialic Acid-Binding Proteins

    Energy Technology Data Exchange (ETDEWEB)

    Baker, H.M.; Basu, I.; Chung, M.C.; Caradoc-Davies, T.; Fraser, J.D.; Baker, E.N.

    2009-06-02

    Staphylococcus aureus is a significant human pathogen. Among its large repertoire of secreted toxins is a group of staphylococcal superantigen-like proteins (SSLs). These are homologous to superantigens but do not have the same activity. SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner. Co-crystallization of SSL5 with the tetrasaccharide sialyl Lewis X (sLe(X)), a key determinant of PSGL-1 binding to P-selectin, led to crystal structures of the SSL5-sLe(X) complex at resolutions of 1.65 and 2.75 A for crystals at two pH values. In both structures, sLe(X) bound to a specific site on the surface of the C-terminal domain of SSL5 in a conformation identical with that bound by P-selectin. Conservation of the key carbohydrate binding residues indicates that this ability to bind human glycans is shared by a substantial subgroup of the SSLs, including SSL2, SSL3, SSL4, SSL5, SSL6, and SSL11. This indicates that the ability to target human glycans is an important property of this group of toxins. Structural comparisons also showed that the Sia binding site in SSL5 contains a substructure that is shared by other Sia binding proteins from bacteria as well as viruses and represents a common binding motif.

  16. An updated assessment of Symbiodinium spp. that associate with common scleractinian corals from Moorea (French Polynesia) reveals high diversity among background symbionts and a novel finding of clade B

    Science.gov (United States)

    Lecellier, Gaël J.; Saulnier, Denis; Planes, Serge; Gueguen, Yannick; Wirshing, Herman H.; Berteaux-Lecellier, Véronique

    2017-01-01

    The adaptative bleaching hypothesis (ABH) states that, depending on the symbiotic flexibility of coral hosts (i.e., the ability of corals to “switch” or “shuffle” their algal symbionts), coral bleaching can lead to a change in the composition of their associated Symbiodinium community and, thus, contribute to the coral’s overall survival. In order to determine the flexibility of corals, molecular tools are required to provide accurate species delineations and to detect low levels of coral-associated Symbiodinium. Here, we used highly sensitive quantitative (real-time) PCR (qPCR) technology to analyse five common coral species from Moorea (French Polynesia), previously screened using only traditional molecular methods, to assess the presence of low-abundance (background) Symbiodinium spp. Similar to other studies, each coral species exhibited a strong specificity to a particular clade, irrespective of the environment. In addition, however, each of the five species harboured at least one additional Symbiodinium clade, among clades A–D, at background levels. Unexpectedly, and for the first time in French Polynesia, clade B was detected as a coral symbiont. These results increase the number of known coral-Symbiodinium associations from corals found in French Polynesia, and likely indicate an underestimation of the ability of the corals in this region to associate with and/or “shuffle” different Symbiodinium clades. Altogether our data suggest that corals from French Polynesia may favor a trade-off between optimizing symbioses with a specific Symbiodinium clade(s), maintaining associations with particular background clades that may play a role in the ability of corals to respond to environmental change. PMID:28168100

  17. An updated assessment of Symbiodinium spp. that associate with common scleractinian corals from Moorea (French Polynesia) reveals high diversity among background symbionts and a novel finding of clade B.

    Science.gov (United States)

    Rouzé, Héloïse; Lecellier, Gaël J; Saulnier, Denis; Planes, Serge; Gueguen, Yannick; Wirshing, Herman H; Berteaux-Lecellier, Véronique

    2017-01-01

    The adaptative bleaching hypothesis (ABH) states that, depending on the symbiotic flexibility of coral hosts (i.e., the ability of corals to "switch" or "shuffle" their algal symbionts), coral bleaching can lead to a change in the composition of their associated Symbiodinium community and, thus, contribute to the coral's overall survival. In order to determine the flexibility of corals, molecular tools are required to provide accurate species delineations and to detect low levels of coral-associated Symbiodinium. Here, we used highly sensitive quantitative (real-time) PCR (qPCR) technology to analyse five common coral species from Moorea (French Polynesia), previously screened using only traditional molecular methods, to assess the presence of low-abundance (background) Symbiodinium spp. Similar to other studies, each coral species exhibited a strong specificity to a particular clade, irrespective of the environment. In addition, however, each of the five species harboured at least one additional Symbiodinium clade, among clades A-D, at background levels. Unexpectedly, and for the first time in French Polynesia, clade B was detected as a coral symbiont. These results increase the number of known coral-Symbiodinium associations from corals found in French Polynesia, and likely indicate an underestimation of the ability of the corals in this region to associate with and/or "shuffle" different Symbiodinium clades. Altogether our data suggest that corals from French Polynesia may favor a trade-off between optimizing symbioses with a specific Symbiodinium clade(s), maintaining associations with particular background clades that may play a role in the ability of corals to respond to environmental change.

  18. New players in the same old game: a system level in silico study to predict type III secretion system and effector proteins in bacterial genomes reveals common themes in T3SS mediated pathogenesis.

    Science.gov (United States)

    Sadarangani, Vineet; Datta, Sunando; Arunachalam, Manonmani

    2013-07-26

    Type III secretion system (T3SS) plays an important role in virulence or symbiosis of many pathogenic or symbiotic bacteria [CHM 2:291-294, 2007; Physiology (Bethesda) 20:326-339, 2005]. T3SS acts like a tunnel between a bacterium and its host through which the bacterium injects 'effector' proteins into the latter [Nature 444:567-573, 2006; COSB 18:258-266, 2008]. The effectors spatially and temporally modify the host signalling pathways [FEMS Microbiol Rev 35:1100-1125, 2011; Cell Host Microbe5:571-579, 2009]. In spite its crucial role in host-pathogen interaction, the study of T3SS and the associated effectors has been limited to a few bacteria [Cell Microbiol 13:1858-1869, 2011; Nat Rev Microbiol 6:11-16, 2008; Mol Microbiol 80:1420-1438, 2011]. Before one set out to perform systematic experimental studies on an unknown set of bacteria it would be beneficial to identify the potential candidates by developing an in silico screening algorithm. A system level study would also be advantageous over traditional laboratory methods to extract an overriding theme for host-pathogen interaction, if any, from the vast resources of data generated by sequencing multiple bacterial genomes. We have developed an in silico protocol in which the most conserved set of T3SS proteins was used as the query against the entire bacterial database with increasingly stringent search parameters. It enabled us to identify several uncharacterized T3SS positive bacteria. We adopted a similar strategy to predict the presence of the already known effectors in the newly identified T3SS positive bacteria. The huge resources of biochemical data [FEMS Microbiol Rev 35:1100-1125, 2011; Cell Host Microbe 5:571-579, 2009; BMC Bioinformatics 7(11):S4, 2010] on the T3SS effectors enabled us to search for the common theme in T3SS mediated pathogenesis. We identified few cellular signalling networks in the host, which are manipulated by most of the T3SS containing pathogens. We went on to look for

  19. The calculation of the optimum parameters to customize the contour three-pulse billing system supply of steam boilers with the phenomenon of "swelling" level in the drum

    Directory of Open Access Journals (Sweden)

    Aleksandr Grinev

    2013-04-01

    Full Text Available The article is devoted to the calculation of the optimal settings automatic control system (ASR level in the boiler steam drum with the phenomenon of "swelling level" typical for boilers with nekipyaschim economizer. The article can be useful for specialists in the field

  20. Prototype recirculating aquaculture system design for juvenile red drum production as part of the Florida Fish and Wildlife Conservation commission’s Hatchery Network Initative

    Science.gov (United States)

    A prototype recirculating aquaculture system for the production of red drum (Sciaenops ocellatus) includes four 10-foot diameter by four foot height tanks for a tank volume of approximately 300 ft3 each (2200 gallons). Water flow for the system is provided for by a low head propeller pump which prov...

  1. Analysis on Corrosion Causes of Drum Strainer in a Nuclear Power Plant%某核电厂鼓形滤网腐蚀原因分析

    Institute of Scientific and Technical Information of China (English)

    林金旭; 廖雪波; 蒋林中; 沈新生

    2015-01-01

    在对某核电厂循环水过滤系统的鼓形滤网进行腐蚀检查过程中,发现鼓形滤网网片底部碳钢骨架不同程度锈蚀,本文从碳钢在海水中的局部腐蚀形式及机理两方面对鼓形滤网骨架腐蚀原因进行简要分析,并提出了降低鼓形滤网腐蚀风险的防腐措施及方法。%During corrosion inspection for the drum screen of Circulating Water Filtration System in a nuclear power plant, It was founded that the Skeleton of the drum screen which under the stainless steel network were serious corroded.The cause which is the corroded Skeleton of the drum screen was Briefly analysed by Forms and mechanism of carbon steel local corrosion in seawater , The measures and methods were advanced to reduce the corrosion risk of the Skeleton of the drum screen in this artide.

  2. The correlation between acoustic and magnetic properties in the long working metal boiler drum with the parameters of the electron microscope

    Energy Technology Data Exchange (ETDEWEB)

    Ababkov, Nikolai, E-mail: n.ababkov@rambler.ru; Smirnov, Alexander, E-mail: galvas.kem@gmail.com [T.F. Gorbachev Kuzbass State Technical University, Vesennjaja str 28, Kemerovo, 650000 Russian Federation (Russian Federation)

    2016-01-15

    The present paper presents comparative analysis of measurement results of acoustic and magnetic properties in long working metal of boiler drums and the results obtained by methods of electronic microscopy. The structure of the metal sample from the fracture zone to the base metal (metal working sample long) and the center of the base metal before welding (weld metal sample) was investigated by electron microscopy. Studies performed by spectral acoustic, magnetic noise and electron microscopic methods were conducted on the same plots and the same samples of long working and weld metal of high-pressure boiler drums. The analysis of research results showed high sensitivity of spectral-acoustic and magnetic-noise methods to definition changes of microstructure parameters. Practical application of spectral-acoustic and magnetic noise NDT method is possible for the detection of irregularities and changes in structural and phase state of the long working and weld metal of boiler drums, made of a special molybdenum steel (such as 20M). The above technique can be used to evaluate the structure and physical-mechanical properties of the long working metal of boiler drums in the energy sector.

  3. Beating the Drums for Attention: Proceedings and Outcomes of the Socrates/Grundtvig Network "International Adult Learners Week in Europe" (IntALWinE)

    Science.gov (United States)

    Bochynek, Bettina, Ed.

    2007-01-01

    "Beating the Drums for Attention" is the metaphorical title chosen to reflect the continuous effort carried out by adult educators to promote learning, to encourage a joyful approach to it and to motivate learners to be part of and actively influence the overall reflexive process they are involved in. What carries the whole movement is…

  4. Ambiguity Revealed

    OpenAIRE

    Subir Bose; Matthew Polisson; Ludovic Renou

    2012-01-01

    We derive necessary and suffcient conditions for data sets composed of state-contingent prices and consumption to be consistent with two prominent models of decision making under ambiguity: variational preferences and smooth ambiguity. The revealed preference conditions for the maxmin expected utility and subjective expected utility models are characterized as special cases.

  5. Ambiguity revealed

    OpenAIRE

    Bayer, Ralph-C; Bose, Subir; Polisson, Matthew; Renou, Ludovic

    2013-01-01

    We derive necessary and sufficient conditions for data sets composed of state-contingent prices and consumption to be consistent with two prominent models of decision making under uncertainty: variational preferences and smooth ambiguity. The revealed preference conditions for subjective expected utility, maxmin expected utility, and multiplier preferences are characterised as special cases. We implement our tests on data from a portfolio choice experiment.

  6. 滚筒干燥数学模拟的研究进展%Development of Mathematic Modeling of Drum Drying

    Institute of Scientific and Technical Information of China (English)

    王瑾; 李树君; 杨延辰; 张清泉; 林亚玲; 韩清华

    2011-01-01

    Drum dryer is widely used in food industry because of its easy operation, good adaptability, high thermal efficiency and short drying time. The design of the drying processing based on the experience is inappropriate. In order to optimize the processing, control the quality of the product and instruct the design of the drum dryer, it's necessary to achieve mathematical model of the drum drying. In this paper the drying theory of the drum drying and the investigation progress of the heat and mass transfer model were introduced. Finally, the next research content and direction of drum drying technology was put forward.%滚筒干燥机因其操作简便、适应性广、热效率高、干燥时间短而被广泛应用于食品工业中.以经验为基础的滚筒干燥工艺不能满足生产需要.建立滚筒干燥过程的数学模型有助于优化工艺参数、提高产品质量、改进滚筒干燥机设计.本文对滚筒干燥原理及其传热传质机理进行了概述,重点介绍了滚筒干燥过程数学模拟的研究进展,并通过对文献的分析总结,对数学模型的完善提出几点建议.

  7. First Industrial Tests of a Drum Monitor Matrix Correction for the Fissile Mass Measurement in Large Volume Historic Metallic Residues with the Differential Die-away Technique

    Energy Technology Data Exchange (ETDEWEB)

    Antoni, R.; Passard, C.; Perot, B.; Batifol, M.; Vandamme, J.C. [CEA, DEN, Cadarache, Nuclear Measurement Laboratory, F-13108 St Paul-lez-Durance, (France); Grassi, G. [AREVA NC, 1 place Jean-Millier, 92084 Paris-La-Defense cedex (France)

    2015-07-01

    The fissile mass in radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA La Hague reprocessing plant is measured by neutron interrogation with the Differential Die-away measurement Technique (DDT. In the next years, old hulls and nozzles mixed with Ion-Exchange Resins will be measured. The ion-exchange resins increase neutron moderation in the matrix, compared to the waste measured in the current process. In this context, the Nuclear Measurement Laboratory (NML) of CEA Cadarache has studied a matrix effect correction method, based on a drum monitor ({sup 3}He proportional counter inside the measurement cavity). A previous study performed with the NML R and D measurement cell PROMETHEE 6 has shown the feasibility of method, and the capability of MCNP simulations to correctly reproduce experimental data and to assess the performances of the proposed correction. A next step of the study has focused on the performance assessment of the method on the industrial station using numerical simulation. A correlation between the prompt calibration coefficient of the {sup 239}Pu signal and the drum monitor signal was established using the MCNPX computer code and a fractional factorial experimental design composed of matrix parameters representative of the variation range of historical waste. Calculations have showed that the method allows the assay of the fissile mass with an uncertainty within a factor of 2, while the matrix effect without correction ranges on 2 decades. In this paper, we present and discuss the first experimental tests on the industrial ACC measurement system. A calculation vs. experiment benchmark has been achieved by performing dedicated calibration measurement with a representative drum and {sup 235}U samples. The preliminary comparison between calculation and experiment shows a satisfactory agreement for the drum monitor. The final objective of this work is to confirm the reliability of the

  8. No Common Opinion on the Common Core

    Science.gov (United States)

    Henderson, Michael B.; Peterson, Paul E.; West, Martin R.

    2015-01-01

    According to the three authors of this article, the 2014 "EdNext" poll yields four especially important new findings: (1) Opinion with respect to the Common Core has yet to coalesce. The idea of a common set of standards across the country has wide appeal, and the Common Core itself still commands the support of a majority of the public.…

  9. Using the Climbing Drum Peel (CDP) Test to Obtain a G(sub IC) value for Core/Facesheet Bonds

    Science.gov (United States)

    Nettles, A. T.; Gregory, Elizabeth D.; Jackson, Justin R.

    2006-01-01

    A method of measuring the Mode I fracture toughness of core/facesheet bonds in sandwich Structures is desired, particularly with the widespread use of models that need this data as input. This study examined if a critical strain energy release rate, G(sub IC), can be obtained from the climbing drum peel (CDP) test. The CDP test is relatively simple to perform and does not rely on measuring small crack lengths such as required by the double cantilever beam (DCB) test. Simple energy methods were used to calculate G(sub IC) from CDP test data on composite facesheets bonded to a honeycomb core. Facesheet thicknesses from 2 to 5 plies were tested to examine the upper and lower bounds on facesheet thickness requirements. Results from the study suggest that the CDP test, with certain provisions, can be used to find the GIG value of a core/facesheet bond.

  10. The simultaneous neutron and photon interrogation method for fissile and non-fissile element separation in radioactive waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Jallu, F. E-mail: fanny.jallu@cea.fr; Lyoussi, A.; Passard, C.; Payan, E.; Recroix, H.; Nurdin, G.; Buisson, A.; Allano, J

    2000-10-01

    Measuring {alpha}-emitters such as ({sup 234,235,236,238}U, {sup 238,239,240,242,244}Pu, {sup 237}Np, {sup 241,243}Am, ...), in solid radioactive waste allows us to quantify the {alpha}-activity in a drum and then to classify it. The simultaneous photon and neutron interrogation experiment (SIMPHONIE) method dealt with in this paper, combines both active neutron interrogation and induced photofission interrogation techniques simultaneously. Its purpose is to quantify fissile ({sup 235}U, {sup 239,241}Pu, ...) and non-fissile ({sup 236,238}U, {sup 238,240}Pu, ...) elements separately in only one measurement. This paper presents the principle of the method, the experimental setup, and the first experimental results obtained using the DGA/ETCA Linac and MiniLinatron pulsed linear electron accelerators located at Arcueil, France. First studies were carried out with U and Pu bare samples.

  11. Dressing Uncivil Neighbor(hoods. Walt Whitman's Adhesive Democracy in “Calamus” and “Drum-Taps”

    Directory of Open Access Journals (Sweden)

    Laura López Peña

    2014-10-01

    Full Text Available This article analyzes 19th-century US poet Walt Whitman’s vindication of “adhesiveness” as imperative to the formation of a social democracy which might heal the neighborly hatreds of a divided United States and bind the nation together at a time of violent fragmentation and Civil War. The article examines Whitman’s location of the possibility of politics and democracy at the interpersonal level, and connects the poet’s political project in his 1860 “Calamus” with that in the 1865 “Drum-Taps”, studying how Whitman’s belief in the uniting capacity of love between men remained constant even as he was witnessing the tragic consequences of a four-year Civil War which would widen even more the irreconcilable gulfs between different Americans.

  12. Design and development of an ultra-compact drum-shaped chamber for combinatorial pulsed laser deposition

    Science.gov (United States)

    Katayama, M.; Itaka, K.; Matsumoto, Y.; Koinuma, H.

    2006-01-01

    We have designed a compact combinatorial pulsed laser deposition (PLD) chamber as a building block of a desktop laboratory for advanced materials research. Development of small-size systems for the growth and characterization of films would greatly help in interconnecting a variety of analytical tools for rapid screening of advanced materials. This PLD chamber has four special features: (1) a drum-shaped growth chamber, (2) a waterwheel-like combinatorial masking system, (3) a multi-target system having one feedthrough, and (4) a small reflection high-energy electron diffraction (RHEED) system. The performance of this system is demonstrated by the RHEED intensity oscillation during homoepitaxial growth of SrTiO 3 as well as by simultaneous fabrication of a ternary phase diagram of rare earth-doped Y 2O 3 phosphors.

  13. A CFD Analysis of Steam Flow in the Two-Stage Experimental Impulse Turbine with the Drum Rotor Arrangement

    Science.gov (United States)

    Yun, Kukchol; Tajč, L.; Kolovratník, M.

    2016-03-01

    The aim of the paper is to present the CFD analysis of the steam flow in the two-stage turbine with a drum rotor and balancing slots. The balancing slot is a part of every rotor blade and it can be used in the same way as balancing holes on the classical rotor disc. The main attention is focused on the explanation of the experimental knowledge about the impact of the slot covering and uncovering on the efficiency of the individual stages and the entire turbine. The pressure and temperature fields and the mass steam flows through the shaft seals, slots and blade cascades are calculated. The impact of the balancing slots covering or uncovering on the reaction and velocity conditions in the stages is evaluated according to the pressure and temperature fields. We have also concentrated on the analysis of the seal steam flow through the balancing slots. The optimized design of the balancing slots has been suggested.

  14. A shape modification of the balancing slot of the impulse turbine stage with the drum rotor arrangement

    Directory of Open Access Journals (Sweden)

    Yun Kukchol

    2016-01-01

    Full Text Available At the previous conference in Český Krumlov it was presented how the balancing slots may influence the efficiency of the impulse turbine stage with the drum rotor arrangement. A few options for shape modification of the balancing slot were also suggested. Implementation of the balancing slots and their possible modifications are subject to various design and technological limitations. During the consultation with the turbine designers and technologists, we were able to determine the modification of the balancing slot which, in terms of their design and production technology, will be the most simple and feasible. It is predicted that the suggested shape modification of the balancing slot will improve the efficiency of the turbine stage. This prediction is then supported by CFD simulations.

  15. Copper extraction from coarsely ground printed circuit boards using moderate thermophilic bacteria in a rotating-drum reactor

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Michael L.M., E-mail: mitchel.marques@yahoo.com.br [Bio& Hydrometallurgy Laboratory, Department of Metallurgical and Materials Engineering, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, MG 35400-000 (Brazil); Leão, Versiane A., E-mail: versiane@demet.em.ufop.br [Bio& Hydrometallurgy Laboratory, Department of Metallurgical and Materials Engineering, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, MG 35400-000 (Brazil); Gomes, Otavio [Centre for Mineral Technology – CETEM, Av Pedro Calmon, 900, 21941-908 Rio de Janeiro (Brazil); Lambert, Fanny; Bastin, David; Gaydardzhiev, Stoyan [Mineral Processing and Recycling, University of Liege, SartTilman, 4000 Liege (Belgium)

    2015-07-15

    Highlights: • Copper bioleaching from PCB (20 mm) by moderate thermophiles was demonstrated. • Larger PCB sheets enable a cost reduction due to the elimination of fine grinding. • Crushing generated cracks in PCB increasing the copper extraction. • A pre-treatment step was necessary to remove the lacquer coating. • High copper extractions (85%) were possible with pulp density of up to 25.0 g/L. - Abstract: The current work reports on a new approach for copper bioleaching from Printed Circuit Board (PCB) by moderate thermophiles in a rotating-drum reactor. Initially leaching of PCB was carried out in shake flasks to assess the effects of particle size (−208 μm + 147 μm), ferrous iron concentration (1.25–10.0 g/L) and pH (1.5–2.5) on copper leaching using mesophile and moderate thermophile microorganisms. Only at a relatively low solid content (10.0 g/L) complete copper extraction was achieved from the particle size investigated. Conversely, high copper extractions were possible from coarse-ground PCB (20 mm-long) working with increased solids concentration (up to 25.0 g/L). Because there was as the faster leaching kinetics at 50 °C Sulfobacillus thermosulfidooxidans was selected for experiments in a rotating-drum reactor with the coarser-sized PCB sheets. Under optimal conditions, copper extraction reached 85%, in 8 days and microscopic observations by SEM–EDS of the on non-leached and leached material suggested that metal dissolution from the internal layers was restricted by the fact that metal surface was not entirely available and accessible for the solution in the case of the 20 mm-size sheets.

  16. DRUM: a new framework for metabolic modeling under non-balanced growth. Application to the carbon metabolism of unicellular microalgae.

    Directory of Open Access Journals (Sweden)

    Caroline Baroukh

    Full Text Available Metabolic modeling is a powerful tool to understand, predict and optimize bioprocesses, particularly when they imply intracellular molecules of interest. Unfortunately, the use of metabolic models for time varying metabolic fluxes is hampered by the lack of experimental data required to define and calibrate the kinetic reaction rates of the metabolic pathways. For this reason, metabolic models are often used under the balanced growth hypothesis. However, for some processes such as the photoautotrophic metabolism of microalgae, the balanced-growth assumption appears to be unreasonable because of the synchronization of their circadian cycle on the daily light. Yet, understanding microalgae metabolism is necessary to optimize the production yield of bioprocesses based on this microorganism, as for example production of third-generation biofuels. In this paper, we propose DRUM, a new dynamic metabolic modeling framework that handles the non-balanced growth condition and hence accumulation of intracellular metabolites. The first stage of the approach consists in splitting the metabolic network into sub-networks describing reactions which are spatially close, and which are assumed to satisfy balanced growth condition. The left metabolites interconnecting the sub-networks behave dynamically. Then, thanks to Elementary Flux Mode analysis, each sub-network is reduced to macroscopic reactions, for which simple kinetics are assumed. Finally, an Ordinary Differential Equation system is obtained to describe substrate consumption, biomass production, products excretion and accumulation of some internal metabolites. DRUM was applied to the accumulation of lipids and carbohydrates of the microalgae Tisochrysis lutea under day/night cycles. The resulting model describes accurately experimental data obtained in day/night conditions. It efficiently predicts the accumulation and consumption of lipids and carbohydrates.

  17. Temporal variation in viral hemorrhagic septicemia virus antibodies in freshwater drum (Aplodinotus grunniens) indicates cyclic transmission in Lake Winnebago, Wisconsin

    Science.gov (United States)

    Wilson-Rothering, Anna; Marcquenski, Susan; Koenigs, Ryan; Bruch, Ronald; Kamke, Kendall; Isermann, Daniel A.; Thurman, Andrew; Toohey-Kurth, Kathy; Goldberg, Tony

    2015-01-01

    Viral hemorrhagic septicemia virus (VHSV) is an emerging pathogen that causes mass mortality in multiple fish species. In 2007, the Great Lakes freshwater strain, type IVb, caused a large die-off of freshwater drum (Aplodinotus grunniens) in Lake Winnebago, Wisconsin, USA. To evaluate the persistence and transmission of VHSV, freshwater drum from Lake Winnebago were tested for antibodies to the virus using recently developed virus neutralization (VN) and enzyme-linked immunosorbent (ELISA) assays. Samples were also tested by real-time reverse transcription-PCR (rRT-PCR) to detect viral RNA. Of 548 serum samples tested, 44 (8.03%) were positive by VN (titers ranging from 1:16 to 1:1,024) and 45 (8.21%) were positive by ELISA, including 7 fish positive by both assays. Antibody prevalence increased with age and was higher in one northwestern area of Lake Winnebago than in other areas. Of 3,864 tissues sampled from 551 fish, 1 spleen and 1 kidney sample from a single adult female fish collected in the spring of 2012 tested positive for VHSV by rRT-PCR, and serum from the same fish tested positive by VN and ELISA. These results suggest that VHSV persists and viral transmission may be active in Lake Winnebago even in years following outbreaks and that wild fish may survive VHSV infection and maintain detectable antibody titers while harboring viral RNA. Influxes of immunologically naive juvenile fish through recruitment may reduce herd immunity, allow VHSV to persist, and drive superannual cycles of transmission that may sporadically manifest as fish kills.

  18. DRUM: A New Framework for Metabolic Modeling under Non-Balanced Growth. Application to the Carbon Metabolism of Unicellular Microalgae

    Science.gov (United States)

    Baroukh, Caroline; Muñoz-Tamayo, Rafael; Steyer, Jean-Philippe; Bernard, Olivier

    2014-01-01

    Metabolic modeling is a powerful tool to understand, predict and optimize bioprocesses, particularly when they imply intracellular molecules of interest. Unfortunately, the use of metabolic models for time varying metabolic fluxes is hampered by the lack of experimental data required to define and calibrate the kinetic reaction rates of the metabolic pathways. For this reason, metabolic models are often used under the balanced growth hypothesis. However, for some processes such as the photoautotrophic metabolism of microalgae, the balanced-growth assumption appears to be unreasonable because of the synchronization of their circadian cycle on the daily light. Yet, understanding microalgae metabolism is necessary to optimize the production yield of bioprocesses based on this microorganism, as for example production of third-generation biofuels. In this paper, we propose DRUM, a new dynamic metabolic modeling framework that handles the non-balanced growth condition and hence accumulation of intracellular metabolites. The first stage of the approach consists in splitting the metabolic network into sub-networks describing reactions which are spatially close, and which are assumed to satisfy balanced growth condition. The left metabolites interconnecting the sub-networks behave dynamically. Then, thanks to Elementary Flux Mode analysis, each sub-network is reduced to macroscopic reactions, for which simple kinetics are assumed. Finally, an Ordinary Differential Equation system is obtained to describe substrate consumption, biomass production, products excretion and accumulation of some internal metabolites. DRUM was applied to the accumulation of lipids and carbohydrates of the microalgae Tisochrysis lutea under day/night cycles. The resulting model describes accurately experimental data obtained in day/night conditions. It efficiently predicts the accumulation and consumption of lipids and carbohydrates. PMID:25105494

  19. Temporal Variation in Viral Hemorrhagic Septicemia Virus Antibodies in Freshwater Drum (Aplodinotus grunniens) Indicates Cyclic Transmission in Lake Winnebago, Wisconsin.

    Science.gov (United States)

    Wilson-Rothering, Anna; Marcquenski, Susan; Koenigs, Ryan; Bruch, Ronald; Kamke, Kendall; Isermann, Daniel; Thurman, Andrew; Toohey-Kurth, Kathy; Goldberg, Tony

    2015-09-01

    Viral hemorrhagic septicemia virus (VHSV) is an emerging pathogen that causes mass mortality in multiple fish species. In 2007, the Great Lakes freshwater strain, type IVb, caused a large die-off of freshwater drum (Aplodinotus grunniens) in Lake Winnebago, Wisconsin, USA. To evaluate the persistence and transmission of VHSV, freshwater drum from Lake Winnebago were tested for antibodies to the virus using recently developed virus neutralization (VN) and enzyme-linked immunosorbent (ELISA) assays. Samples were also tested by real-time reverse transcription-PCR (rRT-PCR) to detect viral RNA. Of 548 serum samples tested, 44 (8.03%) were positive by VN (titers ranging from 1:16 to 1:1,024) and 45 (8.21%) were positive by ELISA, including 7 fish positive by both assays. Antibody prevalence increased with age and was higher in one northwestern area of Lake Winnebago than in other areas. Of 3,864 tissues sampled from 551 fish, 1 spleen and 1 kidney sample from a single adult female fish collected in the spring of 2012 tested positive for VHSV by rRT-PCR, and serum from the same fish tested positive by VN and ELISA. These results suggest that VHSV persists and viral transmission may be active in Lake Winnebago even in years following outbreaks and that wild fish may survive VHSV infection and maintain detectable antibody titers while harboring viral RNA. Influxes of immunologically naive juvenile fish through recruitment may reduce herd immunity, allow VHSV to persist, and drive superannual cycles of transmission that may sporadically manifest as fish kills.

  20. Temporal Variation in Viral Hemorrhagic Septicemia Virus Antibodies in Freshwater Drum (Aplodinotus grunniens) Indicates Cyclic Transmission in Lake Winnebago, Wisconsin

    Science.gov (United States)

    Wilson-Rothering, Anna; Marcquenski, Susan; Koenigs, Ryan; Bruch, Ronald; Kamke, Kendall; Isermann, Daniel; Thurman, Andrew; Toohey-Kurth, Kathy

    2015-01-01

    Viral hemorrhagic septicemia virus (VHSV) is an emerging pathogen that causes mass mortality in multiple fish species. In 2007, the Great Lakes freshwater strain, type IVb, caused a large die-off of freshwater drum (Aplodinotus grunniens) in Lake Winnebago, Wisconsin, USA. To evaluate the persistence and transmission of VHSV, freshwater drum from Lake Winnebago were tested for antibodies to the virus using recently developed virus neutralization (VN) and enzyme-linked immunosorbent (ELISA) assays. Samples were also tested by real-time reverse transcription-PCR (rRT-PCR) to detect viral RNA. Of 548 serum samples tested, 44 (8.03%) were positive by VN (titers ranging from 1:16 to 1:1,024) and 45 (8.21%) were positive by ELISA, including 7 fish positive by both assays. Antibody prevalence increased with age and was higher in one northwestern area of Lake Winnebago than in other areas. Of 3,864 tissues sampled from 551 fish, 1 spleen and 1 kidney sample from a single adult female fish collected in the spring of 2012 tested positive for VHSV by rRT-PCR, and serum from the same fish tested positive by VN and ELISA. These results suggest that VHSV persists and viral transmission may be active in Lake Winnebago even in years following outbreaks and that wild fish may survive VHSV infection and maintain detectable antibody titers while harboring viral RNA. Influxes of immunologically naive juvenile fish through recruitment may reduce herd immunity, allow VHSV to persist, and drive superannual cycles of transmission that may sporadically manifest as fish kills. PMID:26135873

  1. Mathematics revealed

    CERN Document Server

    Berman, Elizabeth

    1979-01-01

    Mathematics Revealed focuses on the principles, processes, operations, and exercises in mathematics.The book first offers information on whole numbers, fractions, and decimals and percents. Discussions focus on measuring length, percent, decimals, numbers as products, addition and subtraction of fractions, mixed numbers and ratios, division of fractions, addition, subtraction, multiplication, and division. The text then examines positive and negative numbers and powers and computation. Topics include division and averages, multiplication, ratios, and measurements, scientific notation and estim

  2. Laparoscopic common bile duct exploration.

    Science.gov (United States)

    Stoker, M E; Leveillee, R J; McCann, J C; Maini, B S

    1991-10-01

    Operative common bile duct exploration, performed in conjunction with cholecystectomy, has been considered the treatment of choice for choledocholithiasis in the presence of an intact gallbladder. With the advent of laparoscopic cholecystectomy, the management of common bile duct stones has been affected. More emphasis is being placed on endoscopic sphincterotomy and options other than operative common duct exploration. Because of this increasing demand, we have developed a new technique for laparoscopic common bile duct exploration performed in the same operative setting as laparoscopic cholecystectomy. A series of five patients who successfully underwent common bile duct exploration, flexible choledochoscopy with stone extraction, and T-tube drainage, all using laparoscopic technique, is reported. Mean postoperative length of hospital stay was 4.6 days. Outpatient T-tube cholangiography was performed in all cases and revealed normal ductal anatomy with no retained stones. Follow-up ranged from 6 weeks to 4 months, and all patients were asymptomatic and had normal liver function tests.

  3. REVEALED ALTRUISM

    OpenAIRE

    Cox, James C; Friedman, Daniel; Sadiraj, Vjollca

    2009-01-01

    This pap er develops a theory of revealed preferences over oneís own and othersímonetary payo§s. We intro duce ìmore altruistic thanî(MAT), a partial ordering over preferences, and interpret it with known parametric mo dels. We also intro duce and illustrate ìmore generous thanî (MGT), a partial ordering over opp ortunity sets. Several recent discussions of altruism fo cus on two player extensive form games of complete information in which the Örst mover (FM) cho oses a more or less gen...

  4. Liquid level analysis and compensation of the CDQ steam drum%干熄焦锅炉汽包液位测量分析与补偿

    Institute of Scientific and Technical Information of China (English)

    邹同方; 单永丰; 孟凡良

    2016-01-01

    With the method of balance containers and differential pressure transmitter measuring CDQ steam drum level, measuring range and transfer of pressure difference transmitter were according to the normal operation of the pressure inside the drum of saturation vapor and saturated water density schedu-ler calculation was obtained. But, in fact from the start to during normal operation of the steam drum pressure from zero gradually to meet the design pressure, and the drum of saturation vapor and saturat-ed water density change with pressure, so in the process of the change, steam drum water level meas-urement will produce great error, and the error increasing with the decreasing pressure. Through the compensation formula and the linear regression equation, the steam drum water level measurement of pressure compensation method was proposed, and got good effect in practice.%采用平衡容器加差压变送器的方式测量干熄焦锅炉汽包液位时,差压变送器的测量范围及迁移量均按正常运行时工作压力汽包内的饱和蒸汽密度和饱和水密度计算求得。实际上,从开工到正常运行,汽包压力是从零逐渐达到设计压力的,而汽包内的饱和蒸汽密度和饱和水密度随压力变化很大,因此,汽包水位的测量会产生很大的误差,误差随压力降低而越来越大。通过补偿公式及线性回归方程,提出对汽包水位测量的压力补偿方法,并在实践中取得良好的效果。

  5. HYDROGEN GENERATION FROM SLUDGE SAMPLE BOTTLES CAUSED BY RADIOLYSIS AND CHEMISTRY WITH CONCETNRATION DETERMINATION IN A STANDARD WASTE BOX (SWB) OR DRUM FOR TRANSPORT

    Energy Technology Data Exchange (ETDEWEB)

    RILEY DL; BRIDGES AE; EDWARDS WS

    2010-03-30

    A volume of 600 mL of sludge, in 4.1 L sample bottles (Appendix 7.6), will be placed in either a Super Pig (Ref. 1) or Piglet (Ref. 2, 3) based on shielding requirements (Ref. 4). Two Super Pigs will be placed in a Standard Waste Box (SWB, Ref. 5), as their weight exceeds the capacity of a drum; two Piglets will be placed in a 55-gallon drum (shown in Appendix 7.2). The generation of hydrogen gas through oxidation/corrosion of uranium metal by its reaction with water will be determined and combined with the hydrogen produced by radiolysis. The hydrogen concentration in the 55-gallon drum and SWB will be calculated to show that the lower flammability limit of 5% hydrogen is not reached. The inner layers (i.e., sample bottle, bag and shielded pig) in the SWB and drum will be evaluated to assure no pressurization occurs as the hydrogen vents from the inner containers (e.g., shielded pigs, etc.). The reaction of uranium metal with anoxic liquid water is highly exothermic; the heat of reaction will be combined with the source term decay heat, calculated from Radcalc, to show that the drum and SWB package heat load limits are satisfied. This analysis does five things: (1) Estimates the H{sub 2} generation from the reaction of uranium metal with water; (2) Estimates the H{sub 2} generation from radiolysis (using Radcalc 4.1); (3) Combines both H{sub 2} generation amounts, from Items 1 and 2, and determines the percent concentration of H{sub 2} in the interior of an SWB with two Super Pigs, and the interior of a 55-gallon drum with two Piglets; (4) From the combined gas generation rate, shows that the pressure at internal layers is minimal; and (5) Calculates the maximum thermal load of the package, both from radioactive decay of the source and daughter products as calculated/reported by Radcalc 4.1, and from the exothermic reaction of uranium metal with water.

  6. Common Privacy Myths

    Science.gov (United States)

    ... Health Information home > privacy + phrs > common privacy myths Common Privacy Myths With the new federal laws protecting ... Here are the truths to some of the common myths: Health information cannot be faxed – FALSE Your ...

  7. Common NICU Equipment

    Science.gov (United States)

    ... newborn intensive care unit (NICU) > Common NICU equipment Common NICU equipment E-mail to a friend Please ... Baby Caring for your baby Feeding your baby Common illnesses Family health & safety Complications & Loss Pregnancy complications ...

  8. Common Variable Immunodeficiency (CVID)

    Science.gov (United States)

    ... with facebook share with twitter share with linkedin Common Variable Immunodeficiency (CVID) Common variable immunodeficiency (CVID) is ... and acquired agammaglobulinemia. Why Is the Study of Common Variable Immunodeficiency (CVID) a Priority for NIAID? CVID ...

  9. Common Discomforts of Pregnancy

    Science.gov (United States)

    ... Home > Pregnancy > Prenatal care > Common discomforts of pregnancy Common discomforts of pregnancy E-mail to a friend ... like back ache and being really tired are common and shouldn’t make you worry. For most ...

  10. 3-D FEM Analysis of Stress Distribution for Connecting Pipe in Mid-pressure Steam Drum%中压汽包接管应力分布的三维有限元分析

    Institute of Scientific and Technical Information of China (English)

    杨伟春; 梁基照

    2000-01-01

    In this paper a stress distribution analysis for connecting pipes in a mid-pressure steam drum has been made by means of the 3-dimensional finite element of ANSYS structure analysis software.The results showed that the maximum values of all kinds of stresses were in the inside of the conjunction area betw een the pipe and the steam-drum cylinder,and these stresses decreased with incre asing distance from this area.

  11. 自然循环汽包炉蒸发回路稳态数学模型%A Steady-state Model of Drum-downcomer-riser Loop in Natural Circulation Drum-type Boilers

    Institute of Scientific and Technical Information of China (English)

    刘福国; 何传怀

    2014-01-01

    A steady-state model was developed which gave detailed account of the thermal-hydraulic phenomena in down-comer-riser-drum loop of a natural circulation drum-type boiler. The model was composed of mass, energy and momentum conservation equations, together with algebraic relationships to describe the working fluids properties and phase change. The empirical relative distribution of heat flux along the height of the furnace was used to drive the model, the averaged heat flux in furnace was solved as unknown, and this fairly accords with the physical process. The model is capable of predicting working fluids temperature, pressure, circulation flow-rates and steam distributions in risers under various operating conditions. Results of the simulation provide a clear insight into two-phase flow and heat transfer conditions in evaporating tubes, and predicated circulation ratios are consistent with results obtained in other literatures.%建立了自然循环汽包炉下降管-上升管-汽包回路的稳态数学模型,该模型是由物质、能量和动量微分方程以及工质物性和相变代数方程组成,炉膛相对热负荷沿高度的一维经验分布作为模型的驱动方程,炉膛平均热负荷是求解变量,因此,热负荷不是独立变量,它与汽包产生的蒸汽量相关,这与实际物理过程较好地相符。该模型能够预测不同运行状态下工质在上升管内的压力、温度、循环流量以及含汽率分布,模拟结果给出了蒸发管内两相流动和传热的清晰图景,循环倍率的预测值与有关文献给出的结果相一致。

  12. THE PROBLEM OF COMMON GOOD

    Directory of Open Access Journals (Sweden)

    Witold Landowski

    2013-12-01

    Full Text Available The main purpose of this article is to discuss the relation between the understanding of human being and the concept of common good. On the one hand, materialist and spiritualist concepts of man lead to the univocal understanding of bonum commune, on the other hand, dualist anthropology entails a breakdown of the unity of common good. The author reveals weak points of these approaches and undertakes an attempt of examining realist vision of man and its impact on the notion of bonum commune. He starts with analyzing the complex structure of human being, which includes the potential and actual nature of human person. Against the background of the personalist anthropology, the author concludes that the common good has not only a material or instrumental, but above all a personal dimension, which makes this good both common and non-antagonistic. [The article written in Polish

  13. Revealing Rembrandt

    Directory of Open Access Journals (Sweden)

    Andrew J Parker

    2014-04-01

    Full Text Available The power and significance of artwork in shaping human cognition is self-evident. The starting point for our empirical investigations is the view that the task of neuroscience is to integrate itself with other forms of knowledge, rather than to seek to supplant them. In our recent work, we examined a particular aspect of the appreciation of artwork using present-day functional magnetic resonance imaging (fMRI. Our results emphasised the continuity between viewing artwork and other human cognitive activities. We also showed that appreciation of a particular aspect of artwork, namely authenticity, depends upon the co-ordinated activity between the brain regions involved in multiple decision making and those responsible for processing visual information. The findings about brain function probably have no specific consequences for understanding how people respond to the art of Rembrandt in comparison with their response to other artworks. However, the use of images of Rembrandt’s portraits, his most intimate and personal works, clearly had a significant impact upon our viewers, even though they have been spatially confined to the interior of an MRI scanner at the time of viewing. Neuroscientific studies of humans viewing artwork have the capacity to reveal the diversity of human cognitive responses that may be induced by external advice or context as people view artwork in a variety of frameworks and settings.

  14. On the Development of Northern Shaanxi Zhidan Sheepskin Drum Sport%陕北志丹羊皮鼓舞运动发展现状探讨

    Institute of Scientific and Technical Information of China (English)

    秦华

    2016-01-01

    The Zhidan of Shaanxi has unique geographical location and historical culture with a sheepskin drum dance as a traditional folk sport. This paper discusses the origin of the sporty through the methods of logical analysis, literature, in-depth investigation aboutthe sheepskin drum dance movement, present situation, difficulties and other issues.%陕北志丹独特的地理位置和历史文化造就了羊皮扇鼓这项传统民俗体育运动,文章通过运用逻辑分析法、文献资料法、调查法等对羊皮扇鼓运动的源起演变、发展现状、存在问题及对策进行探讨,以期为当前陕西新农村文化建设提供参考。

  15. PLC技术在钢桶自动化印字系统中的应用设计*%Application of PLC in Automatic Steel Drums Printing System

    Institute of Scientific and Technical Information of China (English)

    王开; 贲少辉; 马庆尧; 王广宁

    2013-01-01

    针对某厂200L钢桶制造中丝网印字控制存在的问题,运用欧姆龙PLC技术,设计实现了钢桶生产自动化丝网印字控制系统,减少了污染、缩短生产流程,减轻工人劳动强度,提高生产效率,取得较好的经济效益。%The article aims at control issues of silk screen printing in 200L steel drum and applying Omron PLC to resolve it. The design can make steel drum silk screen printing become automatic system. It can reduce pollution, shorten the production process, cut down labor intensity and increase productivity to make more benefit income.

  16. Reactive dynamics analysis of critical Nbsub>2sub>Osub>5sub> sputtering rate for drum-based metal-like deposition.

    Science.gov (United States)

    Song, Shigeng; Li, Cheng; Chu, Hin On; Gibson, Des

    2017-02-01

    Drum-based metal-like film deposition for oxide was investigated using single wavelength in situ monitoring. The data were used to investigate the oxidation mechanism using combined second-order kinetic and parabolic models. A critical Nbsub>2sub>Osub>5sub> deposition rate of 0.507 nm/s was found at drum rotation of 1 rev/s. However, Nbsub>2sub>Osub>5sub> samples prepared at varying deposition rates showed that the deposition rate must be much lower than the critical deposition rate to achieve reasonable absorption. Thus simulation for the volume-fraction of metal in the oxide layer was done using effective medium approximation and a distribution function. Simulation gave high agreement with experimental results and allows the prediction of extinction coefficients at various deposition rates.

  17. PROGRAM TECHNOLOGY OF NC TURNING DRUM-TYPE SHAFTS%腰鼓形轴类零件数控车削加工的编程技术

    Institute of Scientific and Technical Information of China (English)

    樊琳

    2001-01-01

    介绍数控车床加工腰鼓形轴类零件的编程技术,阐述其编程原理及数据处理方法。%This paper presents the programming technique on machining drum-type shaft in NC lathe.The methods of data processing and the principles of NC machining are discussed in detail.

  18. Jiangzhou Drum Music from the Perspective of Cultural Anthropology%文化人类学视野中的绛州鼓乐

    Institute of Scientific and Technical Information of China (English)

    郝珊

    2012-01-01

    Shanxi Province in China is one of the cradles of drums and drum music and a higher art development are found. Originating from J one of the areas where different kinds of iangzhou County, Shanxi Province in the Yellow River Delta, and enjoying the reputation of "a national treasure", Jiangzhou drum music has very rich cul- ture deposits. By means of the analytical method of field study, this paper expounds the cultural background and development process of Jiangzhou drum music, studies its continuity and transformation, and illustrates its culture in a more accurate way under the whole human culture background, in order to make some contribution towards the protection and development of this splendid and traditional folk musical culture.%山西是"鼓"的发源地之一,也是我国鼓乐品种繁多、艺术水平发展较高的地区之一。被誉为"国之魂宝"的绛州鼓乐发源于黄河三角洲的山西新绛县,有着非常丰厚的文化底蕴。为弘扬这一优秀而古老的传统文化,通过田野调查的分析方法,对绛州鼓乐的社会文化背景、发展过程进行阐述,对其传承与变迁过程进行探究,并对这一优秀的民间传统音乐文化在整个人类文化的背景下作出更精确的解释,从而对绛州鼓乐的保护和发展尽一份微薄之力。

  19. Novel geometry for rotor and casing. Radial blowers of the drum rotor type; Neuartige Laufrad- und Gehaeusegeometrie. Radialventilatoren in Trommellaeufer-Bauweise

    Energy Technology Data Exchange (ETDEWEB)

    Riedel, Hans Jochen [YOCIEL Klimatechnik, Leipzig (Germany)

    2008-11-15

    In blowers with drum rotors, i.e. with forward-curved blades, much energy is consumed for raising the internal air flow rate, and they are not efficient in converting this high velocity into static pressure. This was the starting point for new research whose results are presented here. Modifications of the rotor and casing geometry reduced the internal air flow rate and resulted in higher static pressure gradients, lower energy consumption, and also lower noise. (orig.)

  20. 桶装核废物层析γ扫描技术研究%The Study of Tomographic Gamma Ray Scanning for Nuclear Waste Drums

    Institute of Scientific and Technical Information of China (English)

    阳刚; 庹先国; 程智

    2015-01-01

    Tomographic Gamma Scanning is the main analytical method of nuclear waste in drum Non-Destruc-tive-Assay.It can accurately measure the nuclides of the non-uniform nuclear waste with middle or high den-sity in the drum.This paper reviews the research status of Tomographic Gamma Scanning of nuclear waste in drum at home and abroad, summaries the domestic researches at the existing basis and the progresses made, and gives a brief analysis of Tomographic Gamma Scanning′s development trend.Research and development di-rection of Tomographic Gamma Scanning and the domestic problems faced by Tomographic Gamma Scanning of nuclear waste in drum are summarized, and solutions to these problems are briefly offered.%层析γ扫描技术是桶装中低放核废物无损分析技术的主要分析方法,能够准确测量桶装容器内中、高密度非均匀核废物中的核素及其含量。本文综述了国内外桶装核废物层析γ扫描技术研究现状,简述国内现有研究基础和研究进展,并对层析γ扫描技术的发展趋势作了简要分析。提出了层析γ扫描技术研究发展方向和我国桶装核废物层析γ扫描技术面临的问题,并对所面临问题提出了相应的对策。

  1. Analysis of results obtained using the automatic chemical control of the quality of the water heat carrier in the drum boiler of the Ivanovo CHP-3 power plant

    Science.gov (United States)

    Larin, A. B.; Kolegov, A. V.

    2012-10-01

    Results of industrial tests of the new method used for the automatic chemical control of the quality of boiler water of the drum-type power boiler ( P d = 13.8 MPa) are described. The possibility of using an H-cationite column for measuring the electric conductivity of an H-cationized sample of boiler water over a long period of time is shown.

  2. (UnCommonly Connected

    Directory of Open Access Journals (Sweden)

    Emily M. Hodge

    2016-11-01

    Full Text Available As states continue to implement the Common Core State Standards (CCSS, state educational agencies (SEAs are providing professional development and curricular resources to help districts and teachers understand the standards. However, little is known about the resources SEAs endorse, the states and/or organizations sponsoring these resources, and how states and organizations are connected. This study investigates the secondary English/language arts resources provided by 51 SEAs (2,023 resources sponsored by 51 SEAs and 262 intermediary organizations. Social network analysis of states and sponsoring organizations revealed a core-periphery network in which certain states and organizations were frequently named as the sponsors of resources, while other organizations were named as resource sponsors by only one state. SEAs are providing a variety of types of resources, including professional development, curriculum guidelines, articles, and instructional aids. This study offers insight into the most influential actors providing CCSS resources at the state level, as well as how SEAs are supporting instructional capacity through the resources they provide for teachers.

  3. Co-exposure to sunlight enhances the toxicity of naturally weathered Deepwater Horizon oil to early lifestage red drum (Sciaenops ocellatus) and speckled seatrout (Cynoscion nebulosus).

    Science.gov (United States)

    Alloy, Matthew; Garner, Thomas Ross; Bridges, Kristin; Mansfield, Charles; Carney, Michael; Forth, Heather; Krasnec, Michelle; Lay, Claire; Takeshita, Ryan; Morris, Jeffrey; Bonnot, Shane; Oris, James; Roberts, Aaron

    2017-03-01

    The 2010 Deepwater Horizon oil spill resulted in the accidental release of millions of barrels of crude oil into the Gulf of Mexico. Photo-induced toxicity following co-exposure to ultraviolet (UV) radiation is 1 mechanism by which polycyclic aromatic hydrocarbons (PAHs) from oil spills may exert toxicity. Red drum and speckled seatrout are both important fishery resources in the Gulf of Mexico. They spawn near-shore and produce positively buoyant embryos that hatch into larvae in approximately 24 h. The goal of the present study was to determine whether exposure to UV as natural sunlight enhances the toxicity of crude oil to early lifestage red drum and speckled seatrout. Larval fish were exposed to several dilutions of high-energy water-accommodated fractions (HEWAFs) from 2 different oils collected in the field under chain of custody during the 2010 spill and 3 gradations of natural sunlight in a factorial design. Co-exposure to natural sunlight and oil significantly reduced larval survival compared with exposure to oil alone. Although both species were sensitive at PAH concentrations reported during the Deepwater Horizon spill, speckled seatrout demonstrated a greater sensitivity to photo-induced toxicity than red drum. These data demonstrate that even advanced weathering of slicks does not ameliorate the potential for photo-induced toxicity of oil to these species. Environ Toxicol Chem 2017;36:780-785. © 2016 SETAC. © 2016 SETAC.

  4. 锅炉汽包水位测量新技术及其应用%The boiler drum water level measurement techniques and its application

    Institute of Scientific and Technical Information of China (English)

    王福娥; 董国胜

    2013-01-01

    By analyzing the measuring principle and methods of boiler drum water level of several,the paper shows that the model of intelligent boiler drum capacitance liquid level meter has the characteristics of convenient,accurate,full load measurement.At present,being the most advanced,reliable boiler drum water level measurement instrument,it can guarantee the safe production for the power plants.%本文通过分析几种锅炉汽包水位测量的方法及原理,说明新型锅炉智能汽包电容液位计具有方便、准确、全工况测量的特点,是目前锅炉汽包水位测量最先进、可靠的一次仪表,它的应用能使电厂连续正常安全生产得到更好的保障。

  5. Acceptable Knowledge Summary Report for Waste Stream: SR-T001-221F-HET/Drums

    Energy Technology Data Exchange (ETDEWEB)

    Lunsford, G.F.

    1999-08-23

    Since beginning operations in 1954, the Department of Energy's Savannah River Site FB-Line conducted atomic energy defense activities consistent with the listing in Section 10101(3) of the Nuclear Waste Policy Act of 1982. The facility mission was to process and convert dilute plutonium solution into highly purified weapons grade plutonium metal. As a result of various activities conducted in support of the mission (e.g., operation, maintenance, repair, clean up, and facility modifications), the facility generated transuranic waste. This document, along with referenced supporting documents, provides a defensible and auditable record of acceptable knowledge for one of the waste streams from the FB-Line. The waste was packaged in 55-gallon drums, then shipped to the transuranic waste storage facility in ''E'' area of the Savannah River Site. This acceptable knowledge report includes information relating to the facility's history, configuration,equipment, process operations, and waste management practices.

  6. Measurement of the Proton-Air Cross Section with Telescope Array's Middle Drum Detector and Surface Array in Hybrid Mode

    CERN Document Server

    Abbasi, R U; Abu-Zayyad, T; Allen, M; Anderson, R; Azuma, R; Barcikowski, E; Belz, J W; Bergman, D R; Blake, S A; Cady, R; Chae, M J; Cheon, B G; Chiba, J; Chikawa, M; Cho, W R; Fujii, T; Fukushima, M; Goto, T; Hanlon, W; Hayashi, Y; Hayashida, N; Hibino, K; Honda1, K; Ikeda, D; Inoue, N; Ishii, T; Ishimori, R; Ito, H; Ivanov, D; Jui, C C H; Kadota, K; Kakimoto, F; Kalashev, O; Kasahara, K; Kawai, H; Kawakami, S; Kawana, S; Kawata, K; Kido, E; Kim, H B; Kim, J H; Kitamura, S; Kitamura, Y; Kuzmin, V; Kwon, Y J; Lan1, J; Lim, S I; Lundquist, J P; Machida, K; Martens, K; Matsuda, T; Matsuyama, T; Matthews, J N; Minamino, M; Mukai, K; Myers, I; Nagasawa, K; Nagataki1, S; Nakamura, T; Nonaka, T; Nozato, A; Ogio, S; Ogura, J; Ohnishi, M; Ohoka, H; Oki, K; Okuda, T; Ono, M; Oshima, A; Ozawa, S; Park, I H; Pshirkov, M S; Rodriguez, D C; Rubtsov, G; Ryu, D; Sagawa, H; Sakurai, N; Sampson, A L; Scott, L M; Shah, P D; Shibata, F; Shibata, T; Shimodaira, H; Shin, B K; Smith, J D; Sokolsky, P; Springer, R W; Stokes, B T; Stratton, S R; Stroman, T A; Suzawa, T; Takamura, M; Takeda, M; Takeishi, R; Taketa, A; Takita, M; Tameda, Y; Tanaka, H; Tanaka, K; Tanaka, M; Thomas, S B; Thomson, G B; Tinyakov, P; Tkachev, I; Tokuno, H; Tomida, T; Troitsky, S; Tsunesada, Y; Tsutsumi, K; Uchihori, Y; Udo, S; Urban, F; Vasiloff, G; Wong, T; Yamane, R; Yamaoka, H; Yamazaki, K; Yang, J; Yashiro, K; Yoneda, Y; Yoshida, S; Yoshii, H; Zollinger, R; Zundel, Z

    2015-01-01

    In this work we are reporting on the measurement of the proton-air inelastic cross section $\\sigma^{\\rm inel}_{\\rm p-air}$ using the Telescope Array (TA) detector. Based on the measurement of the $\\sigma^{\\rm inel}_{\\rm p-air}$ the proton-proton cross section $\\sigma_{\\rm p-p}$ value is also determined at $\\sqrt{s} = 95$ TeV. Detecting cosmic ray events at ultra high energies with Telescope Array enables us to study this fundamental parameter that we are otherwise unable to access with particle accelerators. The data used in this report is collected over five years using hybrid events observed by the Middle Drum fluorescence detector together with the surface array detector. The value of the $\\sigma^{\\rm inel}_{\\rm p-air}$ is found to be equal to $ 567.0 \\pm 70.5 [{\\rm Stat.}] ^{+25}_{-29} [{\\rm Sys.}]$ mb. The total proton-proton cross section is subsequently inferred from Glauber Formalism and Block, Halzen and Stanev QCD inspired fit and is found to be equal to $170_{-44}^{+48} [{\\rm Stat.}] \\pm _{-19}^{+1...

  7. Two-stage anaerobic digestion of biodegradable municipal solid waste using a rotating drum mesh filter bioreactor and anaerobic filter.

    Science.gov (United States)

    Walker, M; Banks, C J; Heaven, S

    2009-09-01

    A rotating drum mesh filter bioreactor (RDMFBR) with a 100 microm mesh coupled to an anaerobic filter was used for the anaerobic digestion of biodegradable municipal solid waste (BMW). Duplicate systems were operated for 72 days at an organic loading rate (OLR) of 7.5 g VS l(-1) d(-1). Early in the experiment most of the methane was produced in the 2nd stage. This situation gradually reversed as methanogenesis became established in the 1st stage digester, which eventually produced 86-87% of the total system methane. The total methane production was 0.2 l g(-1) VS(added) with 60-62% volatile solids destruction. No fouling was experienced during the experiment at a transmembrane flux rate of 3.5 l m(-2) h(-1). The system proved to be robust and stably adjusted to a shock loading increase to 15 g VS l(-1) d(-1), although this reduced the overall methane production to 0.15 l g(-1) VS(added).

  8. Design and operation of a rotating drum radio frequency plasma reactor for the modification of free nanoparticles.

    Science.gov (United States)

    Shearer, Jeffrey C; Fisher, Ellen R

    2013-06-01

    A rotating drum rf plasma reactor was designed to functionalize the surface of nanoparticles and other unusually shaped substrates through plasma polymerization and surface modification. This proof-of-concept reactor design utilizes plasma polymerized allyl alcohol to add OH functionality to Fe2O3 nanoparticles. The reactor design is adaptable to current plasma hardware, eliminating the need for an independent reactor setup. Plasma polymerization performed on Si wafers, Fe2O3 nanoparticles supported on Si wafers, and freely rotating Fe2O3 nanoparticles demonstrated the utility of the reactor for a multitude of processes. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy were used to characterize the surface of the substrates prior to and after plasma deposition, and scanning electron microscopy was used to verify that no extensive change in the size or shape of the nanoparticles occurred because of the rotating motion of the reactor. The reactor design was also extended to a non-depositing NH3 plasma modification system to demonstrate the reactor design is effective for multiple plasma processes.

  9. Finding Common Ground with the Common Core

    Science.gov (United States)

    Moisan, Heidi

    2015-01-01

    This article examines the journey of museum educators at the Chicago History Museum in understanding the Common Core State Standards and implementing them in our work with the school audience. The process raised questions about our teaching philosophy and our responsibility to our audience. Working with colleagues inside and outside of our…

  10. How Common Is the Common Core?

    Science.gov (United States)

    Thomas, Amande; Edson, Alden J.

    2014-01-01

    Since the introduction of the Common Core State Standards for Mathematics (CCSSM) in 2010, stakeholders in adopting states have engaged in a variety of activities to understand CCSSM standards and transition from previous state standards. These efforts include research, professional development, assessment and modification of curriculum resources,…

  11. Finding Common Ground with the Common Core

    Science.gov (United States)

    Moisan, Heidi

    2015-01-01

    This article examines the journey of museum educators at the Chicago History Museum in understanding the Common Core State Standards and implementing them in our work with the school audience. The process raised questions about our teaching philosophy and our responsibility to our audience. Working with colleagues inside and outside of our…

  12. Commonly Abused Drugs Charts

    Science.gov (United States)

    ... Common Forms Common Ways Taken DEA Schedule Juice, Gym Candy, Pumpers, Roids Nandrolone (Oxandrin ® ), oxandrolone (Anadrol ® ), oxymetholone ( ... swings; tiredness; restlessness; loss of appetite; insomnia; lowered sex drive; depression, sometimes leading to suicide attempts. Treatment ...

  13. Common Asthma Triggers

    Science.gov (United States)

    ... Film Asthma Clinical Guidelines Air Pollution & Respiratory Health Common Asthma Triggers Recommend on Facebook Tweet Share Compartir ... t avoid the triggers. Some of the most common triggers are: Tobacco Smoke Tobacco smoke is unhealthy ...

  14. Common Eye Disorders

    Science.gov (United States)

    ... www.cdc.gov/emailupdates/">What's this? Submit Button Common Eye Disorders Recommend on Facebook Tweet Share Compartir ... macular degeneration, cataract, diabetic retinopathy, and glaucoma. Other common eye disorders include amblyopia and strabismus. For a ...

  15. Common Misconceptions about Cholesterol

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Common Misconceptions about Cholesterol Updated:Jul 5,2017 How ... do you know about cholesterol? Here are some common misconceptions — and the truth. High cholesterol isn’t ...

  16. Common Conditions in Newborns

    Science.gov (United States)

    ... Stages Listen Español Text Size Email Print Share Common Conditions in Newborns Page Content Article Body Some physical conditions are especially common during the first couple of weeks after birth. ...

  17. Common Tests for Arrhythmia

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Common Tests for Arrhythmia Updated:Dec 21,2016 Several ... diagnose an arrhythmia. View an animation of arrhythmia . Common Tests for Arrhythmia Holter monitor (continuous ambulatory electrocardiographic ...

  18. 广西南丹县中堡苗族铜鼓的主要仪式运用%The Main Ritual Use of the Bronze Drum of Miao Nationality in Zhongbao Village of Nandan County in Guangxi

    Institute of Scientific and Technical Information of China (English)

    陶磊

    2015-01-01

    中堡苗族的铜鼓习俗时至今日依然保持着活态的形式,在中堡苗族社群中铜鼓必须与木鼓搭配使用,组成一个不可分割的仪式单元。铜鼓与木鼓作为沟通祖先和神灵的神器被主要运用于周期性的农业岁时节日和作为人生礼仪的“葬礼”中。铜鼓在岁时节日中的使用主要是为了满足人们对于农业生产增殖、丰产的愿望,在葬礼中使用铜鼓则主要是为了隔断死者灵魂与现实世界的联系,实现人们阴安阳乐、回归正常生活秩序的目的。%Till now,the custom of Zhongbao Miao’s bronze drum remains in a vivid form. Especially,in the community,the bronze drum must be used together with the wooden drum in order to compose an integral unit of ceremony. Bronze drum and wooden drum as the communication artifact of ancestors and gods are mainly used in periodically agricultural festivals and life rituals of"funeral". The use of bronze drum in the agricultural festival is mainly to meet people for the proliferation of agricultural production,the wish of fertility;the bronze drum used in the funeral is to cut off the contact between the soul of the dead and the real world so as to achieve the purpose of peace for the dead and happiness for the alive and returning to normal life order.

  19. Basic Approaches of Complex Interaction DrumTerrain for Vibratory Compaction

    Directory of Open Access Journals (Sweden)

    Gigel Florin Capatana

    2013-09-01

    Full Text Available In this paper the author tries to use a new method to evaluate and analyze the interaction between roller and terrain. The analysis is rheological approached, with a predominantly dynamic behaviour, so as to reveal the compatibility of the working body performances with the characteristics of the terrain. The basic idea shows that it must be assured the energy transfer maximization in the interaction between the two components of the system. The model must have permanent and continuous adjustments of the material characteristics so it can be evaluated the technological capability. The fulfilling of these objectives will be provided by using a complex model with both distributed and concentrated elements which can have rheology of elastic, dissipative and plastic types. The first conclusions of the presented study goes to the idea that the harmonization of the basic parameters of the model with the experimental values can lead to structural and functional optimizations of the entire technological system.

  20. Tragedy of the Commons

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    The tittle refers to an article from 1968 by Garrett Hardin, using the metaphore of the common grazing land in villages in old time. These 'Commons' were for free use for people in the commounity to have some sheep grazing. This system was based on a certain social solidarity and ethic....... With an individualistic and selfish attitude this would collaps, since each single citizen could benefit from putting more sheep on the common, which would eventually collapse by overgrazing. The metaphore is applied to our common planet, and our ability to built up institutions, economics and ethics, geared for sharing...