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Sample records for double parallel symplectic

  1. Unified picture of non-geometric fluxes and T-duality in double field theory via graded symplectic manifolds

    Energy Technology Data Exchange (ETDEWEB)

    Heller, Marc Andre [Particle Theory and Cosmology Group, Department of Physics,Graduate School of Science, Tohoku University,Aoba-ku, Sendai 980-8578 (Japan); Ikeda, Noriaki [Department of Mathematical Sciences, Ritsumeikan University,Kusatsu, Shiga 525-8577 (Japan); Watamura, Satoshi [Particle Theory and Cosmology Group, Department of Physics,Graduate School of Science, Tohoku University,Aoba-ku, Sendai 980-8578 (Japan)

    2017-02-15

    We give a systematic derivation of the local expressions of the NS H-flux, geometric F- as well as non-geometric Q- and R-fluxes in terms of bivector β- and two-form B-potentials including vielbeins. They are obtained using a supergeometric method on QP-manifolds by twist of the standard Courant algebroid on the generalized tangent space without flux. Bianchi identities of the fluxes are easily deduced. We extend the discussion to the case of the double space and present a formulation of T-duality in terms of canonical transformations between graded symplectic manifolds. Thus, we find a unified description of geometric as well as non-geometric fluxes and T-duality transformations in double field theory. Finally, the construction is compared to the formerly introduced Poisson Courant algebroid, a Courant algebroid on a Poisson manifold, as a model for R-flux.

  2. Symplectic entropy

    International Nuclear Information System (INIS)

    De Nicola, Sergio; Fedele, Renato; Man'ko, Margarita A; Man'ko, Vladimir I

    2007-01-01

    The tomographic-probability description of quantum states is reviewed. The symplectic tomography of quantum states with continuous variables is studied. The symplectic entropy of the states with continuous variables is discussed and its relation to Shannon entropy and information is elucidated. The known entropic uncertainty relations of the probability distribution in position and momentum of a particle are extended and new uncertainty relations for symplectic entropy are obtained. The partial case of symplectic entropy, which is optical entropy of quantum states, is considered. The entropy associated to optical tomogram is shown to satisfy the new entropic uncertainty relation. The example of Gaussian states of harmonic oscillator is studied and the entropic uncertainty relations for optical tomograms of the Gaussian state are shown to minimize the uncertainty relation

  3. A symplectic map for trajectories of magnetic field lines in double-null divertor tokamaks

    Science.gov (United States)

    Crank, Willie; Ali, Halima; Punjabi, Alkesh

    2009-11-01

    The coordinates of the area-preserving map equations for integration of magnetic field line trajectories in tokamaks can be any coordinates for which a transformation to (ψ,θ,φ) coordinates exists [A. Punjabi, H. Ali, T. Evans, and A. Boozer, Phys. Lett. A 364, 140 (2007)]. ψ is toroidal magnetic flux, θ is poloidal angle, and φ is toroidal angle. This freedom is exploited to construct a map that represents the magnetic topology of double-null divertor tokamaks. For this purpose, the generating function of the simple map [A. Punjabi, A. Verma, and A. Boozer, Phys. Rev. Lett. 69, 3322 (1992)] is slightly modified. The resulting map equations for the double-null divertor tokamaks are: x1=x0-ky0(1-y0^2 ), y1=y0+kx1. k is the map parameter. It represents the generic topological effects of toroidal asymmetries. The O-point is at (0.0). The X-points are at (0,±1). The equilibrium magnetic surfaces are calculated. These surfaces are symmetric about the x- and y- axes. The widths of stochastic layer near the X-points in the principal plane, and the fractal dimensions of the magnetic footprints on the inboard and outboard side of upper and lower X-points are calculated from the map. This work is supported by US Department of Energy grants DE-FG02-07ER54937, DE-FG02-01ER54624 and DE-FG02-04ER54793.

  4. Associated symplectic and co-symplectic structures

    International Nuclear Information System (INIS)

    Frescura, F.A.M.; Lubczonok, G.

    1991-01-01

    In a recent article, the authors introduced a new geometric structure which they proposed to call co-symplectic geometry. This structure is based on a symmetric bilinear form of signature zero and leads to a geometry that is, in many respects, analogous to the symplectic geometry. Its usefulness lies principally in the fact that it provides scope for the geometrization of a number of familiar structures in physics which are not so easily amenable by the methods of symplectic geometry. These include the angular momentum operators of quantum theory, the Dirac operators in relativistic quantum field theory. It is anticipated that, in conjunction with the more familiar symplectic geometry, the co-symplectic geometry will go some way to providing the tools necessary for a full geometrization of physics. In this paper, a co-symplectic structure on the cotangent bundle T * X of an arbitrary manifold X is defined, and the notion of associated symplectic and co-symplectic structures is introduced. By way of example, the two-dimensional case is considered in some detail. The general case is investigated, and some implications of these results for polarizations in geometric quantization are considered

  5. Classical Mechanics and Symplectic Integration

    DEFF Research Database (Denmark)

    Nordkvist, Nikolaj; Hjorth, Poul G.

    2005-01-01

    Content: Classical mechanics: Calculus of variations, Lagrange’s equations, Symmetries and Noether’s theorem, Hamilton’s equations, cannonical transformations, integrable systems, pertubation theory. Symplectic integration: Numerical integrators, symplectic integrators, main theorem on symplectic...

  6. Lectures on Symplectic Geometry

    CERN Document Server

    Silva, Ana Cannas

    2001-01-01

    The goal of these notes is to provide a fast introduction to symplectic geometry for graduate students with some knowledge of differential geometry, de Rham theory and classical Lie groups. This text addresses symplectomorphisms, local forms, contact manifolds, compatible almost complex structures, Kaehler manifolds, hamiltonian mechanics, moment maps, symplectic reduction and symplectic toric manifolds. It contains guided problems, called homework, designed to complement the exposition or extend the reader's understanding. There are by now excellent references on symplectic geometry, a subset of which is in the bibliography of this book. However, the most efficient introduction to a subject is often a short elementary treatment, and these notes attempt to serve that purpose. This text provides a taste of areas of current research and will prepare the reader to explore recent papers and extensive books on symplectic geometry where the pace is much faster. For this reprint numerous corrections and cl...

  7. Complex and symplectic geometry

    CERN Document Server

    Medori, Costantino; Tomassini, Adriano

    2017-01-01

    This book arises from the INdAM Meeting "Complex and Symplectic Geometry", which was held in Cortona in June 2016. Several leading specialists, including young researchers, in the field of complex and symplectic geometry, present the state of the art of their research on topics such as the cohomology of complex manifolds; analytic techniques in Kähler and non-Kähler geometry; almost-complex and symplectic structures; special structures on complex manifolds; and deformations of complex objects. The work is intended for researchers in these areas.

  8. Collective symplectic integrators

    International Nuclear Information System (INIS)

    McLachlan, Robert I; Modin, Klas; Verdier, Olivier

    2014-01-01

    We construct symplectic integrators for Lie–Poisson systems. The integrators are standard symplectic (partitioned) Runge–Kutta methods. Their phase space is a symplectic vector space equipped with a Hamiltonian action with momentum map J whose range is the target Lie–Poisson manifold, and their Hamiltonian is collective, that is, it is the target Hamiltonian pulled back by J. The method yields, for example, a symplectic midpoint rule expressed in 4 variables for arbitrary Hamiltonians on so(3) ∗ . The method specializes in the case that a sufficiently large symmetry group acts on the fibres of J, and generalizes to the case that the vector space carries a bifoliation. Examples involving many classical groups are presented. (paper)

  9. Symplectic S5 action on symplectic homotopy K3 surfaces

    Indian Academy of Sciences (India)

    HONGXIA LI

    Let X be a symplectic homotopy K3 surface and G = S5 act on X symplectically. In this paper, we give a weak classification of the G action on X by discussing the fixed-point set structure. Besides, we analyse the exoticness of smooth structures of X under the action of G. Keywords. K3 surfaces; symplectic actions; exotic ...

  10. Symplectic geometry and Fourier analysis

    CERN Document Server

    Wallach, Nolan R

    2018-01-01

    Suitable for graduate students in mathematics, this monograph covers differential and symplectic geometry, homogeneous symplectic manifolds, Fourier analysis, metaplectic representation, quantization, Kirillov theory. Includes Appendix on Quantum Mechanics by Robert Hermann. 1977 edition.

  11. Symplectic methods in circular accelerators

    International Nuclear Information System (INIS)

    Forest, E.

    1994-01-01

    By now symplectic integration has been applied to many problems in classical mechanics. It is my conviction that the field of particle simulation in circular rings is ideally suited for the application of symplectic integration. In this paper, I present a short description symplectic tools in circular storage rings

  12. Contact and symplectic topology

    CERN Document Server

    Colin, Vincent; Stipsicz, András

    2014-01-01

    Symplectic and contact geometry naturally emerged from the mathematical description of classical physics. The discovery of new rigidity phenomena and properties satisfied by these geometric structures launched a new research field worldwide. The intense activity of many European research groups in this field is reflected by the ESF Research Networking Programme "Contact And Symplectic Topology" (CAST). The lectures of the Summer School in Nantes (June 2011) and of the CAST Summer School in Budapest (July 2012) provide a nice panorama of many aspects of the present status of contact and symplectic topology. The notes of the minicourses offer a gentle introduction to topics which have developed in an amazing speed in the recent past. These topics include 3-dimensional and higher dimensional contact topology, Fukaya categories, asymptotically holomorphic methods in contact topology, bordered Floer homology, embedded contact homology, and flexibility results for Stein manifolds.

  13. Complex/Symplectic Mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Wu-yen; Kachru, Shamit; /Stanford U., ITP /SLAC; Tomasiello, Alessandro; /Stanford U., ITP

    2005-10-28

    We construct a class of symplectic non-Kaehler and complex non-Kaehler string theory vacua, extending and providing evidence for an earlier suggestion by Polchinski and Strominger. The class admits a mirror pairing by construction. Comparing hints from a variety of sources, including ten-dimensional supergravity and KK reduction on SU(3)-structure manifolds, suggests a picture in which string theory extends Reid's fantasy to connect classes of both complex non-Kaehler and symplectic non-Kaehler manifolds.

  14. Symplectic quantum structure

    Energy Technology Data Exchange (ETDEWEB)

    Voit, Kay-Michael

    2008-06-16

    In the first part we considered the quantum phase space in terms of noncommutative differential geometry. Following relevant literature, a short introduction to vector fields and differential forms on the differential vector space M{sub N}(C) was given. Special emphasis has been laid on the construction of a canonical symplectic form analogous to the one known from classical mechanics. The canonical choice of this form has been shown to be just the (scaled) commutator of two matrices. Using the Schwinger basis, the symplectic form derived in the first sections has been further examined by calculating concrete expressions for products of general matrices and their commutators which are, as we remember, just the symplectic form. Subsequently, a discrete analog to the continuous theory has been developed, in which the lattice of the quantum phase space forms the base space, and the Heisenberg group including the Schwinger elements is identified with the fiber space. In the continuum limit it could be shown that the discrete theory seamlessly passed into the commonly known continuous theory of connection forms on fiber bundles. The connection form and its exterior covariant derivation, the curvature form, have been calculated. It has been found that the curvature form can even be pulled back to the symplectic form by the section defined by the Schwinger elements. (orig.)

  15. Ground state of the parallel double quantum dot system.

    Science.gov (United States)

    Zitko, Rok; Mravlje, Jernej; Haule, Kristjan

    2012-02-10

    We resolve the controversy regarding the ground state of the parallel double quantum dot system near half filling. The numerical renormalization group predicts an underscreened Kondo state with residual spin-1/2 magnetic moment, ln2 residual impurity entropy, and unitary conductance, while the Bethe ansatz solution predicts a fully screened impurity, regular Fermi-liquid ground state, and zero conductance. We calculate the impurity entropy of the system as a function of the temperature using the hybridization-expansion continuous-time quantum Monte Carlo technique, which is a numerically exact stochastic method, and find excellent agreement with the numerical renormalization group results. We show that the origin of the unconventional behavior in this model is the odd-symmetry "dark state" on the dots.

  16. Orthogonal and symplectic

    CERN Document Server

    Mason, A M

    2018-01-01

    In this paper the authors apply to the zeros of families of L-functions with orthogonal or symplectic symmetry the method that Conrey and Snaith (Correlations of eigenvalues and Riemann zeros, 2008) used to calculate the n-correlation of the zeros of the Riemann zeta function. This method uses the Ratios Conjectures (Conrey, Farmer, and Zimbauer, 2008) for averages of ratios of zeta or L-functions. Katz and Sarnak (Zeroes of zeta functions and symmetry, 1999) conjecture that the zero statistics of families of L-functions have an underlying symmetry relating to one of the classical compact groups U(N), O(N) and USp(2N). Here the authors complete the work already done with U(N) (Conrey and Snaith, Correlations of eigenvalues and Riemann zeros, 2008) to show how new methods for calculating the n-level densities of eigenangles of random orthogonal or symplectic matrices can be used to create explicit conjectures for the n-level densities of zeros of L-functions with orthogonal or symplectic symmetry, including al...

  17. The Permanent Magnet Operating Mechanism of Double Coil Parallel Driven at a High Speed

    Directory of Open Access Journals (Sweden)

    WEI Xau-Lao

    2017-02-01

    Full Text Available Abstract:Operating mechanism is the main part of breaker,and the quality of breaker will directly influence the safe operation of power system. Because of the continuous improvement requirements of switch,in order to mak this actuator faster and more powerful closing,this paper proposes a double coil parallel driven permanent magnet actuator at a high speed. This paper expounds the working principle of single and double coil parallel driven permanent magnet actuator. It uses Ansoft building model and contrasts test results. In prance we designed and produced the single and double coil parallel driven permanent magnet actuator for experimental study. The simulation and experiment results show that double coil parallel driven permanent magnet actuator,compared with single coil parallel driven permanent magnet actuator,has a better and faster action performance. Thus,the double coil parallel driven permanent magnet actuator achieves a kind of optimization.

  18. Function theory on symplectic manifolds

    CERN Document Server

    Polterovich, Leonid

    2014-01-01

    This is a book on symplectic topology, a rapidly developing field of mathematics which originated as a geometric tool for problems of classical mechanics. Since the 1980s, powerful methods such as Gromov's pseudo-holomorphic curves and Morse-Floer theory on loop spaces gave rise to the discovery of unexpected symplectic phenomena. The present book focuses on function spaces associated with a symplectic manifold. A number of recent advances show that these spaces exhibit intriguing properties and structures, giving rise to an alternative intuition and new tools in symplectic topology. The book provides an essentially self-contained introduction into these developments along with applications to symplectic topology, algebra and geometry of symplectomorphism groups, Hamiltonian dynamics and quantum mechanics. It will appeal to researchers and students from the graduate level onwards. I like the spirit of this book. It formulates concepts clearly and explains the relationship between them. The subject matter is i...

  19. Symplectic multi-particle tracking on GPUs

    Science.gov (United States)

    Liu, Zhicong; Qiang, Ji

    2018-05-01

    A symplectic multi-particle tracking model is implemented on the Graphic Processing Units (GPUs) using the Compute Unified Device Architecture (CUDA) language. The symplectic tracking model can preserve phase space structure and reduce non-physical effects in long term simulation, which is important for beam property evaluation in particle accelerators. Though this model is computationally expensive, it is very suitable for parallelization and can be accelerated significantly by using GPUs. In this paper, we optimized the implementation of the symplectic tracking model on both single GPU and multiple GPUs. Using a single GPU processor, the code achieves a factor of 2-10 speedup for a range of problem sizes compared with the time on a single state-of-the-art Central Processing Unit (CPU) node with similar power consumption and semiconductor technology. It also shows good scalability on a multi-GPU cluster at Oak Ridge Leadership Computing Facility. In an application to beam dynamics simulation, the GPU implementation helps save more than a factor of two total computing time in comparison to the CPU implementation.

  20. Supersymmetric symplectic quantum mechanics

    Science.gov (United States)

    de Menezes, Miralvo B.; Fernandes, M. C. B.; Martins, Maria das Graças R.; Santana, A. E.; Vianna, J. D. M.

    2018-02-01

    Symplectic Quantum Mechanics SQM considers a non-commutative algebra of functions on a phase space Γ and an associated Hilbert space HΓ to construct a unitary representation for the Galilei group. From this unitary representation the Schrödinger equation is rewritten in phase space variables and the Wigner function can be derived without the use of the Liouville-von Neumann equation. In this article we extend the methods of supersymmetric quantum mechanics SUSYQM to SQM. With the purpose of applications in quantum systems, the factorization method of the quantum mechanical formalism is then set within supersymmetric SQM. A hierarchy of simpler hamiltonians is generated leading to new computation tools for solving the eigenvalue problem in SQM. We illustrate the results by computing the states and spectra of the problem of a charged particle in a homogeneous magnetic field as well as the corresponding Wigner function.

  1. On orbifold criteria for symplectic toric quotients

    DEFF Research Database (Denmark)

    Farsi, Carla; Herbig, Hans-Christian; Seaton, Christopher

    2013-01-01

    We introduce the notion of regular symplectomorphism and graded regular symplectomorphism between singular phase spaces. Our main concern is to exhibit examples of unitary torus representations whose symplectic quotients cannot be graded regularly symplectomorphic to the quotient of a symplectic...

  2. Vorticity and symplecticity in multi-symplectic, Lagrangian gas dynamics

    Science.gov (United States)

    Webb, G. M.; Anco, S. C.

    2016-02-01

    The Lagrangian, multi-dimensional, ideal, compressible gas dynamic equations are written in a multi-symplectic form, in which the Lagrangian fluid labels, m i (the Lagrangian mass coordinates) and time t are the independent variables, and in which the Eulerian position of the fluid element {x}={x}({m},t) and the entropy S=S({m},t) are the dependent variables. Constraints in the variational principle are incorporated by means of Lagrange multipliers. The constraints are: the entropy advection equation S t = 0, the Lagrangian map equation {{x}}t={u} where {u} is the fluid velocity, and the mass continuity equation which has the form J=τ where J={det}({x}{ij}) is the Jacobian of the Lagrangian map in which {x}{ij}=\\partial {x}i/\\partial {m}j and τ =1/ρ is the specific volume of the gas. The internal energy per unit volume of the gas \\varepsilon =\\varepsilon (ρ ,S) corresponds to a non-barotropic gas. The Lagrangian is used to define multi-momenta, and to develop de Donder-Weyl Hamiltonian equations. The de Donder-Weyl equations are cast in a multi-symplectic form. The pullback conservation laws and the symplecticity conservation laws are obtained. One class of symplecticity conservation laws give rise to vorticity and potential vorticity type conservation laws, and another class of symplecticity laws are related to derivatives of the Lagrangian energy conservation law with respect to the Lagrangian mass coordinates m i . We show that the vorticity-symplecticity laws can be derived by a Lie dragging method, and also by using Noether’s second theorem and a fluid relabelling symmetry which is a divergence symmetry of the action. We obtain the Cartan-Poincaré form describing the equations and we discuss a set of differential forms representing the equation system.

  3. Formal Symplectic Groupoid of a Deformation Quantization

    Science.gov (United States)

    Karabegov, Alexander V.

    2005-08-01

    We give a self-contained algebraic description of a formal symplectic groupoid over a Poisson manifold M. To each natural star product on M we then associate a canonical formal symplectic groupoid over M. Finally, we construct a unique formal symplectic groupoid ‘with separation of variables’ over an arbitrary Kähler-Poisson manifold.

  4. Elementary symplectic topology and mechanics

    CERN Document Server

    Cardin, Franco

    2015-01-01

    This is a short tract on the essentials of differential and symplectic geometry together with a basic introduction to several applications of this rich framework: analytical mechanics, the calculus of variations, conjugate points & Morse index, and other physical topics. A central feature is the systematic utilization of Lagrangian submanifolds and their Maslov-Hörmander generating functions. Following this line of thought, first introduced by Wlodemierz Tulczyjew, geometric solutions of Hamilton-Jacobi equations, Hamiltonian vector fields and canonical transformations are described by suitable Lagrangian submanifolds belonging to distinct well-defined symplectic structures. This unified point of view has been particularly fruitful in symplectic topology, which is the modern Hamiltonian environment for the calculus of variations, yielding sharp sufficient existence conditions. This line of investigation was initiated by Claude Viterbo in 1992; here, some primary consequences of this theory are exposed in...

  5. Symplecticity in Beam Dynamics: An Introduction

    Energy Technology Data Exchange (ETDEWEB)

    Rees, John R

    2003-06-10

    A particle in a particle accelerator can often be considered a Hamiltonian system, and when that is the case, its motion obeys the constraints of the Symplectic Condition. This tutorial monograph derives the condition from the requirement that a canonical transformation must yield a new Hamiltonian system from an old one. It then explains some of the consequences of symplecticity and discusses examples of its applications, touching on symplectic matrices, phase space and Liouville's Theorem, Lagrange and Poisson brackets, Lie algebra, Lie operators and Lie transformations, symplectic maps and symplectic integrators.

  6. Collective coordinates on symplectic manifolds

    International Nuclear Information System (INIS)

    Razumov, A.V.; Taranov, A.Yu.

    1981-01-01

    For an arbitrary Lie group of canonical transformations on a symplectic manifold collective coordinates are introduced. They describe a motion of the dynamical system as a whole under the group transformations. Some properties of Lie group of canonical transformations are considered [ru

  7. Symplectic and trigonometrically fitted symplectic methods of second and third order

    International Nuclear Information System (INIS)

    Monovasilis, Th.; Simos, T.E.

    2006-01-01

    The numerical integration of Hamiltonian systems by symplectic and trigonometrically symplectic method is considered in this Letter. We construct new symplectic and trigonometrically symplectic methods of second and third order. We apply our new methods as well as other existing methods to the numerical integration of the harmonic oscillator, the 2D harmonic oscillator with an integer frequency ratio and an orbit problem studied by Stiefel and Bettis

  8. Reduction of symplectic principal R-bundles

    International Nuclear Information System (INIS)

    Lacirasella, Ignazio; Marrero, Juan Carlos; Padrón, Edith

    2012-01-01

    We describe a reduction process for symplectic principal R-bundles in the presence of a momentum map. These types of structures play an important role in the geometric formulation of non-autonomous Hamiltonian systems. We apply this procedure to the standard symplectic principal R-bundle associated with a fibration π:M→R. Moreover, we show a reduction process for non-autonomous Hamiltonian systems on symplectic principal R-bundles. We apply these reduction processes to several examples. (paper)

  9. Symplectic Geometric Algorithms for Hamiltonian Systems

    CERN Document Server

    Feng, Kang

    2010-01-01

    "Symplectic Geometry Algorithms for Hamiltonian Systems" will be useful not only for numerical analysts, but also for those in theoretical physics, computational chemistry, celestial mechanics, etc. The book generalizes and develops the generating function and Hamilton-Jacobi equation theory from the perspective of the symplectic geometry and symplectic algebra. It will be a useful resource for engineers and scientists in the fields of quantum theory, astrophysics, atomic and molecular dynamics, climate prediction, oil exploration, etc. Therefore a systematic research and development

  10. The Maslov index in symplectic Banach spaces

    DEFF Research Database (Denmark)

    Booss-Bavnbek, Bernhelm; Zhu, Chaofeng

    . Using such decompositions the authors define the Maslov index of the curve by symplectic reduction to the classical finite-dimensional case. The authors prove the transitivity of repeated symplectic reductions and obtain the invariance of the Maslov index under symplectic reduction while recovering all...... for varying well-posed boundary conditions on manifolds with boundary and obtain the splitting formula of the spectral flow on partitioned manifolds....

  11. Symplectic integration for complex wigglers

    International Nuclear Information System (INIS)

    Forest, E.; Ohmi, K.

    1992-01-01

    Using the example of the helical wiggler proposed for the KEK photon factory, we show how to integrate the equation of motion through the wiggler. The integration is performed in cartesian coordinates. For the usual expanded Hamiltonian (without square root), we derive a first order symplectic integrator for the purpose of tracking through a wiggler in a ring. We also show how to include classical radiation for the computation of the damping decrement

  12. Symplectic maps for accelerator lattices

    International Nuclear Information System (INIS)

    Warnock, R.L.; Ruth, R.; Gabella, W.

    1988-05-01

    We describe a method for numerical construction of a symplectic map for particle propagation in a general accelerator lattice. The generating function of the map is obtained by integrating the Hamilton-Jacobi equation as an initial-value problem on a finite time interval. Given the generating function, the map is put in explicit form by means of a Fourier inversion technique. We give an example which suggests that the method has promise. 9 refs., 9 figs

  13. The Maslov index in symplectic Banach spaces

    CERN Document Server

    Booss-Bavnbek, Bernhelm

    2018-01-01

    The authors consider a curve of Fredholm pairs of Lagrangian subspaces in a fixed Banach space with continuously varying weak symplectic structures. Assuming vanishing index, they obtain intrinsically a continuously varying splitting of the total Banach space into pairs of symplectic subspaces. Using such decompositions the authors define the Maslov index of the curve by symplectic reduction to the classical finite-dimensional case. The authors prove the transitivity of repeated symplectic reductions and obtain the invariance of the Maslov index under symplectic reduction while recovering all the standard properties of the Maslov index. As an application, the authors consider curves of elliptic operators which have varying principal symbol, varying maximal domain and are not necessarily of Dirac type. For this class of operator curves, the authors derive a desuspension spectral flow formula for varying well-posed boundary conditions on manifolds with boundary and obtain the splitting formula of the spectral f...

  14. Singularity theory and equivariant symplectic maps

    CERN Document Server

    Bridges, Thomas J

    1993-01-01

    The monograph is a study of the local bifurcations of multiparameter symplectic maps of arbitrary dimension in the neighborhood of a fixed point.The problem is reduced to a study of critical points of an equivariant gradient bifurcation problem, using the correspondence between orbits ofa symplectic map and critical points of an action functional. New results onsingularity theory for equivariant gradient bifurcation problems are obtained and then used to classify singularities of bifurcating period-q points. Of particular interest is that a general framework for analyzing group-theoretic aspects and singularities of symplectic maps (particularly period-q points) is presented. Topics include: bifurcations when the symplectic map has spatial symmetry and a theory for the collision of multipliers near rational points with and without spatial symmetry. The monograph also includes 11 self-contained appendices each with a basic result on symplectic maps. The monograph will appeal to researchers and graduate student...

  15. Multi-symplectic Birkhoffian structure for PDEs with dissipation terms

    International Nuclear Information System (INIS)

    Su Hongling; Qin Mengzhao; Wang Yushun; Scherer, Rudolf

    2010-01-01

    A generalization of the multi-symplectic form for Hamiltonian systems to self-adjoint systems with dissipation terms is studied. These systems can be expressed as multi-symplectic Birkhoffian equations, which leads to a natural definition of Birkhoffian multi-symplectic structure. The concept of Birkhoffian multi-symplectic integrators for Birkhoffian PDEs is investigated. The Birkhoffian multi-symplectic structure is constructed by the continuous variational principle, and the Birkhoffian multi-symplectic integrator by the discrete variational principle. As an example, two Birkhoffian multi-symplectic integrators for the equation describing a linear damped string are given.

  16. On local invariants of singular symplectic forms

    Science.gov (United States)

    Domitrz, Wojciech

    2017-04-01

    We find a complete set of local invariants of singular symplectic forms with the structurally stable Martinet hypersurface on a 2 n-dimensional manifold. In the C-analytic category this set consists of the Martinet hypersurface Σ2, the restriction of the singular symplectic form ω to TΣ2 and the kernel of ω n - 1 at the point p ∈Σ2. In the R-analytic and smooth categories this set contains one more invariant: the canonical orientation of Σ2. We find the conditions to determine the kernel of ω n - 1 at p by the other invariants. In dimension 4 we find sufficient conditions to determine the equivalence class of a singular symplectic form-germ with the structurally smooth Martinet hypersurface by the Martinet hypersurface and the restriction of the singular symplectic form to it. We also study the singular symplectic forms with singular Martinet hypersurfaces. We prove that the equivalence class of such singular symplectic form-germ is determined by the Martinet hypersurface, the canonical orientation of its regular part and the restriction of the singular symplectic form to its regular part if the Martinet hypersurface is a quasi-homogeneous hypersurface with an isolated singularity.

  17. NMR parallel Q-meter with double-balanced-mixer detection for polarized target experiments

    International Nuclear Information System (INIS)

    Boissevain, J.; Tippens, W.B.

    1983-01-01

    A constant-voltage, parallel-tuned nuclear magnetic resonance (NMR) circuit, patterned after a Liverpool design, has been developed for polarized target experiments. Measuring the admittance of the resonance circuit allows advantageous use of double-balanced mixer detection. The resonant circuit is tolerant of stray capacitance between the NMR coil and the target cavity, thus easing target-cell-design constraints. The reference leg of the circuit includes a voltage-controlled attenuator and phase shifter for ease of tuning. The NMR output features a flat background and has good linearity and stability

  18. Flat-top passband filter based on parallel-coupled double microring resonators in silicon

    Science.gov (United States)

    Huang, Qingzhong; Xiao, Xi; Li, Yuntao; Li, Zhiyong; Yu, Yude; Yu, Jinzhong

    2009-08-01

    Optical filters with box-like response were designed and realized based on parallel-coupled double microrings in silicon-on-insulator. The properties of this design are simulated, considering the impact of the center-to-center distance of two rings, and coupling efficiency. Flat-top passband in the drop channel of the fabricated device was demonstrated with a 1dB bandwidth of 0.82nm, a 1dB/10dB bandwidth ratio of 0.51, an out of band rejection ratio of 14.6dB, as well as a free spectrum range of 13.6nm.

  19. Categorical Cell Decomposition of Quantized Symplectic Algebraic Varieties

    OpenAIRE

    Bellamy, Gwyn; Dodd, Christopher; McGerty, Kevin; Nevins, Thomas

    2013-01-01

    We prove a new symplectic analogue of Kashiwara’s equivalence from D–module\\ud theory. As a consequence, we establish a structure theory for module categories over\\ud deformation-quantizations that mirrors, at a higher categorical level, the BiałynickiBirula\\ud stratification of a variety with an action of the multiplicative group Gm . The\\ud resulting categorical cell decomposition provides an algebrogeometric parallel to the\\ud structure of Fukaya categories of Weinstein manifolds. From it,...

  20. Generalized reciprocity principle for discrete symplectic systems

    Directory of Open Access Journals (Sweden)

    Julia Elyseeva

    2015-12-01

    Full Text Available This paper studies transformations for conjoined bases of symplectic difference systems $Y_{i+1}=\\mathcal S_{i}Y_{i}$ with the symplectic coefficient matrices $\\mathcal S_i.$ For an arbitrary symplectic transformation matrix $P_{i}$ we formulate most general sufficient conditions for $\\mathcal S_{i},\\, P_{i}$ which guarantee that $P_{i}$ preserves oscillatory properties of conjoined bases $Y_{i}.$ We present examples which show that our new results extend the applicability of the discrete transformation theory.

  1. Photoluminescence spectra of n-doped double quantum wells in a parallel magnetic field

    International Nuclear Information System (INIS)

    Huang, D.; Lyo, S.K.

    1999-01-01

    We show that the photoluminescence (PL) line shapes from tunnel-split ground sublevels of n-doped thin double quantum wells (DQW close-quote s) are sensitively modulated by an in-plane magnetic field B parallel at low temperatures (T). The modulation is caused by the B parallel -induced distortion of the electronic structure. The latter arises from the relative shift of the energy-dispersion parabolas of the two quantum wells (QW close-quote s) in rvec k space, both in the conduction and valence bands, and formation of an anticrossing gap in the conduction band. Using a self-consistent density-functional theory, the PL spectra and the band-gap narrowing are calculated as a function of B parallel , T, and the homogeneous linewidths. The PL spectra from symmetric and asymmetric DQW close-quote s are found to show strikingly different behavior. In symmetric DQW close-quote s with a high density of electrons, two PL peaks are obtained at B parallel =0, representing the interband transitions between the pair of the upper (i.e., antisymmetric) levels and that of the lower (i.e., symmetric) levels of the ground doublets. As B parallel increases, the upper PL peak develops an N-type kink, namely a maximum followed by a minimum, and merges with the lower peak, which rises monotonically as a function of B parallel due to the diamagnetic energy. When the electron density is low, however, only a single PL peak, arising from the transitions between the lower levels, is obtained. In asymmetric DQW close-quote s, the PL spectra show mainly one dominant peak at all B parallel close-quote s. In this case, the holes are localized in one of the QW close-quote s at low T and recombine only with the electrons in the same QW. At high electron densities, the upper PL peak shows an N-type kink like in symmetric DQW close-quote s. However, the lower peak is absent at low B parallel close-quote s because it arises from the inter-QW transitions. Reasonable agreement is obtained with recent

  2. Multiparametric quantum symplectic phase space

    International Nuclear Information System (INIS)

    Parashar, P.; Soni, S.K.

    1992-07-01

    We formulate a consistent multiparametric differential calculus on the quadratic coordinate algebra of the quantum vector space and use this as a tool to obtain a deformation of the associated symplectic phase space involving n(n-1)/2+1 deformation parameters. A consistent calculus on the relation subspace is also constructed. This is achieved with the help of a restricted ansatz and solving the consistency conditions to directly arrive at the main commutation structures without any reference to the R-matrix. However, the non-standard R-matrices for GL r,qij (n) and Sp r,qij (2n) can be easily read off from the commutation relations involving coordinates and derivatives. (author). 9 refs

  3. Symplectic Attitude Estimation for Small Satellites

    National Research Council Canada - National Science Library

    Valpiani, James M; Palmer, Phillip L

    2006-01-01

    .... Symplectic numerical methods are applied to the Extended Kalman Filter (EKF) algorithm to give the SKF, which outperforms the standard EKF in the presence of nonlinearity and low measurement noise in the 1-D case...

  4. Note on Symplectic SVD-Like Decomposition

    Directory of Open Access Journals (Sweden)

    AGOUJIL Said

    2016-02-01

    Full Text Available The aim of this study was to introduce a constructive method to compute a symplectic singular value decomposition (SVD-like decomposition of a 2n-by-m rectangular real matrix A, based on symplectic refectors.This approach used a canonical Schur form of skew-symmetric matrix and it allowed us to compute eigenvalues for the structured matrices as Hamiltonian matrix JAA^T.

  5. Symplectic topology of integrable Hamiltonian systems

    International Nuclear Information System (INIS)

    Nguyen Tien Zung.

    1993-08-01

    We study the topology of integrable Hamiltonian systems, giving the main attention to the affine structure of their orbit spaces. In particular, we develop some aspects of Fomenko's theory about topological classification of integrable non-degenerate systems, and consider some relations between such systems and ''pure'' contact and symplectic geometry. We give a notion of integrable surgery and use it to obtain some interesting symplectic structures. (author). Refs, 10 figs

  6. Strongly stable real infinitesimally symplectic mappings

    NARCIS (Netherlands)

    Cushman, R.; Kelley, A.

    We prove that a mapA εsp(σ,R), the set of infinitesimally symplectic maps, is strongly stable if and only if its centralizerC(A) insp(σ,R) contains only semisimple elements. Using the theorem that everyB insp(σ,R) close toA is conjugate by a real symplectic map to an element ofC(A), we give a new

  7. Further optimization of a parallel double-effect organosilicon distillation scheme through exergy analysis

    International Nuclear Information System (INIS)

    Sun, Jinsheng; Dai, Leilei; Shi, Ming; Gao, Hong; Cao, Xijia; Liu, Guangxin

    2014-01-01

    In our previous work, a significant improvement in organosilicon monomer distillation using parallel double-effect heat integration between a heavies removal column and six other columns, as well as heat integration between methyltrichlorosilane and dimethylchlorosilane columns, reduced the total exergy loss of the currently running counterpart by 40.41%. Further research regarding this optimized scheme demonstrated that it was necessary to reduce the higher operating pressure of the methyltrichlorosilane column, which is required for heat integration between the methyltrichlorosilane and dimethylchlorosilane columns. Therefore, in this contribution, a challenger scheme is presented with heat pumps introduced separately from the originally heat-coupled methyltrichlorosilane and dimethylchlorosilane columns in the above-mentioned optimized scheme, which is the prototype for this work. Both schemes are simulated using the same purity requirements used in running industrial units. The thermodynamic properties from the simulation are used to calculate the energy consumption and exergy loss of the two schemes. The results show that the heat pump option further reduces the flowsheet energy consumption and exergy loss by 27.35% and 10.98% relative to the prototype scheme. These results indicate that the heat pumps are superior to heat integration in the context of energy-savings during organosilicon monomer distillation. - Highlights: • Combine the paralleled double-effect and heat pump distillation to organosilicon distillation. • Compare the double-effect with the heat pump in saving energy. • Further cut down the flowsheet energy consumption and exergy loss by 27.35% and 10.98% respectively

  8. Coherent State Projection Operator Representation of Symplectic Transformations as a Loyal Representation of Symplectic Group

    Science.gov (United States)

    Fan, Hong-Yi; Chen, Jun-Hua

    2002-08-01

    We find that the coherent state projection operator representation of symplectic transformation constitutes a loyal group representation of symplectic group. The result of successively applying squeezing operators on number state can be easily derived. The project supported by National Natural Science Foundation of China under Grant No. 10575057 and the President Foundation of the Chinese Academy of Sciences

  9. Weakly nonlocal symplectic structures, Whitham method and weakly nonlocal symplectic structures of hydrodynamic type

    International Nuclear Information System (INIS)

    Maltsev, A Ya

    2005-01-01

    We consider the special type of field-theoretical symplectic structures called weakly nonlocal. The structures of this type are, in particular, very common for integrable systems such as KdV or NLS. We introduce here the special class of weakly nonlocal symplectic structures which we call weakly nonlocal symplectic structures of hydrodynamic type. We investigate then the connection of such structures with the Whitham averaging method and propose the procedure of 'averaging' the weakly nonlocal symplectic structures. The averaging procedure gives the weakly nonlocal symplectic structure of hydrodynamic type for the corresponding Whitham system. The procedure also gives 'action variables' corresponding to the wave numbers of m-phase solutions of the initial system which give the additional conservation laws for the Whitham system

  10. Generation and detection of spin polarization in parallel coupled double quantum dots connected to four terminals

    International Nuclear Information System (INIS)

    An, Xing-Tao; Mu, Hui-Ying; Li, Yu-Xian; Liu, Jian-Jun

    2011-01-01

    A four-terminal parallel double quantum dots (QDs) device is proposed to generate and detect the spin polarization in QDs. It is found that the spin accumulation in QDs and the spin-polarized currents in the upper and down leads can be generated when a bias voltage is applied between the left and right leads. It is more interesting that the spin polarization in the QDs can be detected using the upper and down leads. Moreover, the direction and magnitude of the spin polarization in the QDs, and in the upper and down leads can be tuned by the energy levels of QDs and the bias. -- Highlights: → The spin polarization in the quantum dots can be generated and controlled. → The spin polarization in quantum dots can be detected by the nonferromagnetic leads. → The system our studied is a discrete level spin Hall system.

  11. Symplectic Maps from Cluster Algebras

    Directory of Open Access Journals (Sweden)

    Allan P. Fordy

    2011-09-01

    Full Text Available We consider nonlinear recurrences generated from the iteration of maps that arise from cluster algebras. More precisely, starting from a skew-symmetric integer matrix, or its corresponding quiver, one can define a set of mutation operations, as well as a set of associated cluster mutations that are applied to a set of affine coordinates (the cluster variables. Fordy and Marsh recently provided a complete classification of all such quivers that have a certain periodicity property under sequences of mutations. This periodicity implies that a suitable sequence of cluster mutations is precisely equivalent to iteration of a nonlinear recurrence relation. Here we explain briefly how to introduce a symplectic structure in this setting, which is preserved by a corresponding birational map (possibly on a space of lower dimension. We give examples of both integrable and non-integrable maps that arise from this construction. We use algebraic entropy as an approach to classifying integrable cases. The degrees of the iterates satisfy a tropical version of the map.

  12. A fine adjustment mechanism of the second crystal in a double-crystal monochromator with a 3-PS parallel manipulator

    International Nuclear Information System (INIS)

    Cao Chongzhen; Gao, X.; Ma, P.; Yu, H.; Wang, F.; Huang, Y.; Liu, P.

    2005-01-01

    A novel fine adjustment mechanism of the second crystal in a double-crystal monochromator is put forward, which is based on a 3-PS parallel manipulator and the magnetic force. Not only is the principle of fine adjusting the pitch angle and the roll angle analyzed, but also optimization of the structure parameters of the permanent magnet, a key part of the fine adjustment mechanism. The fine adjustment mechanism with the 3-PS parallel manipulator has been applied successfully in the double-crystal monochromator of 4W1B beam line in the Beijing Synchrotron Radiation Facility (BSRF)

  13. An algorithm for symplectic implicit Taylor-map tracking

    International Nuclear Information System (INIS)

    Yan, Y.; Channell, P.; Syphers, M.

    1992-10-01

    An algorithm has been developed for converting an ''order-by-order symplectic'' Taylor map that is truncated to an arbitrary order (thus not exactly symplectic) into a Courant-Snyder matrix and a symplectic implicit Taylor map for symplectic tracking. This algorithm is implemented using differential algebras, and it is numerically stable and fast. Thus, lifetime charged-particle tracking for large hadron colliders, such as the Superconducting Super Collider, is now made possible

  14. Multi-symplectic integrators: numerical schemes for Hamiltonian PDEs that conserve symplecticity

    Science.gov (United States)

    Bridges, Thomas J.; Reich, Sebastian

    2001-06-01

    The symplectic numerical integration of finite-dimensional Hamiltonian systems is a well established subject and has led to a deeper understanding of existing methods as well as to the development of new very efficient and accurate schemes, e.g., for rigid body, constrained, and molecular dynamics. The numerical integration of infinite-dimensional Hamiltonian systems or Hamiltonian PDEs is much less explored. In this Letter, we suggest a new theoretical framework for generalizing symplectic numerical integrators for ODEs to Hamiltonian PDEs in R2: time plus one space dimension. The central idea is that symplecticity for Hamiltonian PDEs is directional: the symplectic structure of the PDE is decomposed into distinct components representing space and time independently. In this setting PDE integrators can be constructed by concatenating uni-directional ODE symplectic integrators. This suggests a natural definition of multi-symplectic integrator as a discretization that conserves a discrete version of the conservation of symplecticity for Hamiltonian PDEs. We show that this approach leads to a general framework for geometric numerical schemes for Hamiltonian PDEs, which have remarkable energy and momentum conservation properties. Generalizations, including development of higher-order methods, application to the Euler equations in fluid mechanics, application to perturbed systems, and extension to more than one space dimension are also discussed.

  15. Relative symplectic caps, 4-genus and fibered knots

    Indian Academy of Sciences (India)

    We prove relative versions of the symplectic capping theorem and sufficiency of Giroux's criterion for Stein fillability and use these to study the 4-genus of knots. More precisely, suppose we have a symplectic 4-manifold with convex boundary and a symplectic surface in such that is a transverse knot in .

  16. Translating solitons to symplectic and Lagrangian mean curvature flows

    International Nuclear Information System (INIS)

    Han Xiaoli; Li Jiayu

    2007-05-01

    In this paper, we construct finite blow-up examples for symplectic mean curvature flows and we study symplectic translating solitons. We prove that there is no translating solitons with vertical bar α vertical bar ≤ α 0 to the symplectic mean curvature flow or to the almost calibrated Lagrangian mean curvature flow for some α 0 . (author)

  17. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes

    NARCIS (Netherlands)

    Kerkhoffs, G. M. M. J.; Struijs, P. A. A.; de Wit, C.; Rahlfs, V. W.; Zwipp, H.; van Dijk, C. N.

    2004-01-01

    Objective: To compare the effectiveness and safety of the triple combination Phlogenzym ( rutoside, bromelain, and trypsin) with double combinations, the single substances, and placebo. Design: Multinational, multicentre, double blind, randomised, parallel group design with eight groups structured

  18. Infinitesimal Deformations of a Formal Symplectic Groupoid

    Science.gov (United States)

    Karabegov, Alexander

    2011-09-01

    Given a formal symplectic groupoid G over a Poisson manifold ( M, π 0), we define a new object, an infinitesimal deformation of G, which can be thought of as a formal symplectic groupoid over the manifold M equipped with an infinitesimal deformation {π_0 + \\varepsilon π_1} of the Poisson bivector field π 0. To any pair of natural star products {(ast,tildeast)} having the same formal symplectic groupoid G we relate an infinitesimal deformation of G. We call it the deformation groupoid of the pair {(ast,tildeast)} . To each star product with separation of variables {ast} on a Kähler-Poisson manifold M we relate another star product with separation of variables {hatast} on M. We build an algorithm for calculating the principal symbols of the components of the logarithm of the formal Berezin transform of a star product with separation of variables {ast} . This algorithm is based upon the deformation groupoid of the pair {(ast,hatast)}.

  19. Characterization and solvability of quasipolynomial symplectic mappings

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez-Bermejo, Benito [ESCET (Edificio Departamental II), Universidad Rey Juan Carlos, Calle Tulipan S/N, 28933-Mostoles-Madrid (Spain); Brenig, Leon [Service de Physique Theorique et Mathematique, Universite Libre de Bruxelles, Campus Plaine, CP 231, Boulevard du Triomphe, B-1050 Brussels (Belgium)

    2004-02-13

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper, the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given.

  20. Characterization and solvability of quasipolynomial symplectic mappings

    International Nuclear Information System (INIS)

    Hernandez-Bermejo, Benito; Brenig, Leon

    2004-01-01

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper, the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given

  1. Characterization and solvability of quasipolynomial symplectic mappings

    Science.gov (United States)

    Hernández-Bermejo, Benito; Brenig, Léon

    2004-02-01

    Quasipolynomial (or QP) mappings constitute a wide generalization of the well-known Lotka-Volterra mappings, of importance in different fields such as population dynamics, physics, chemistry or economy. In addition, QP mappings are a natural discrete-time analogue of the continuous QP systems, which have been extensively used in different pure and applied domains. After presenting the basic definitions and properties of QP mappings in a previous paper [1], the purpose of this work is to focus on their characterization by considering the existence of symplectic QP mappings. In what follows such QP symplectic maps are completely characterized. Moreover, use of the QP formalism can be made in order to demonstrate that all QP symplectic mappings have an analytical solution that is explicitly and generally constructed. Examples are given.

  2. Stochastic symplectic and multi-symplectic methods for nonlinear Schrödinger equation with white noise dispersion

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Jianbo, E-mail: jianbocui@lsec.cc.ac.cn [Institute of Computational Mathematics and Scientific/Engineering Computing, Chinese Academy of Sciences, Beijing, 100190 (China); Hong, Jialin, E-mail: hjl@lsec.cc.ac.cn [Institute of Computational Mathematics and Scientific/Engineering Computing, Chinese Academy of Sciences, Beijing, 100190 (China); Liu, Zhihui, E-mail: liuzhihui@lsec.cc.ac.cn [Institute of Computational Mathematics and Scientific/Engineering Computing, Chinese Academy of Sciences, Beijing, 100190 (China); Zhou, Weien, E-mail: weienzhou@nudt.edu.cn [College of Science, National University of Defense Technology, Changsha 410073 (China)

    2017-08-01

    We indicate that the nonlinear Schrödinger equation with white noise dispersion possesses stochastic symplectic and multi-symplectic structures. Based on these structures, we propose the stochastic symplectic and multi-symplectic methods, which preserve the continuous and discrete charge conservation laws, respectively. Moreover, we show that the proposed methods are convergent with temporal order one in probability. Numerical experiments are presented to verify our theoretical results.

  3. Stochastic symplectic and multi-symplectic methods for nonlinear Schrödinger equation with white noise dispersion

    International Nuclear Information System (INIS)

    Cui, Jianbo; Hong, Jialin; Liu, Zhihui; Zhou, Weien

    2017-01-01

    We indicate that the nonlinear Schrödinger equation with white noise dispersion possesses stochastic symplectic and multi-symplectic structures. Based on these structures, we propose the stochastic symplectic and multi-symplectic methods, which preserve the continuous and discrete charge conservation laws, respectively. Moreover, we show that the proposed methods are convergent with temporal order one in probability. Numerical experiments are presented to verify our theoretical results.

  4. Infinitesimal deformations of a formal symplectic groupoid

    OpenAIRE

    Karabegov, Alexander

    2010-01-01

    Given a formal symplectic groupoid $G$ over a Poisson manifold $(M, \\pi_0)$, we define a new object, an infinitesimal deformation of $G$, which can be thought of as a formal symplectic groupoid over the manifold $M$ equipped with an infinitesimal deformation $\\pi_0 + \\epsilon \\pi_1$ of the Poisson bivector field $\\pi_0$. The source and target mappings of a deformation of $G$ are deformations of the source and target mappings of $G$. To any pair of natural star products $(\\ast, \\tilde\\ast)$ ha...

  5. Known-plaintext attack on the double phase encoding and its implementation with parallel hardware

    Science.gov (United States)

    Wei, Hengzheng; Peng, Xiang; Liu, Haitao; Feng, Songlin; Gao, Bruce Z.

    2008-03-01

    A known-plaintext attack on the double phase encryption scheme implemented with parallel hardware is presented. The double random phase encoding (DRPE) is one of the most representative optical cryptosystems developed in mid of 90's and derives quite a few variants since then. Although the DRPE encryption system has a strong power resisting to a brute-force attack, the inherent architecture of DRPE leaves a hidden trouble due to its linearity nature. Recently the real security strength of this opto-cryptosystem has been doubted and analyzed from the cryptanalysis point of view. In this presentation, we demonstrate that the optical cryptosystems based on DRPE architecture are vulnerable to known-plain text attack. With this attack the two encryption keys in the DRPE can be accessed with the help of the phase retrieval technique. In our approach, we adopt hybrid input-output algorithm (HIO) to recover the random phase key in the object domain and then infer the key in frequency domain. Only a plaintext-ciphertext pair is sufficient to create vulnerability. Moreover this attack does not need to select particular plaintext. The phase retrieval technique based on HIO is an iterative process performing Fourier transforms, so it fits very much into the hardware implementation of the digital signal processor (DSP). We make use of the high performance DSP to accomplish the known-plaintext attack. Compared with the software implementation, the speed of the hardware implementation is much fast. The performance of this DSP-based cryptanalysis system is also evaluated.

  6. Deformations of symplectic Lie algebroids, deformations of holomorphic symplectic structures, and index theorems

    DEFF Research Database (Denmark)

    Nest, Ryszard; Tsygan, Boris

    2001-01-01

    Recently Kontsevich solved the classification problem for deformation quantizations of all Poisson structures on a manifold. In this paper we study those Poisson structures for which the explicit methods of Fedosov can be applied, namely the Poisson structures coming from symplectic Lie algebroids......, as well as holomorphic symplectic structures. For deformations of these structures we prove the classification theorems and a general a general index theorem....

  7. Controlling nonsequential double ionization of Ne with parallel-polarized two-color laser pulses.

    Science.gov (United States)

    Luo, Siqiang; Ma, Xiaomeng; Xie, Hui; Li, Min; Zhou, Yueming; Cao, Wei; Lu, Peixiang

    2018-05-14

    We measure the recoil-ion momentum distributions from nonsequential double ionization of Ne by two-color laser pulses consisting of a strong 800-nm field and a weak 400-nm field with parallel polarizations. The ion momentum spectra show pronounced asymmetries in the emission direction, which depend sensitively on the relative phase of the two-color components. Moreover, the peak of the doubly charged ion momentum distribution shifts gradually with the relative phase. The shifted range is much larger than the maximal vector potential of the 400-nm laser field. Those features are well recaptured by a semiclassical model. Through analyzing the correlated electron dynamics, we found that the energy sharing between the two electrons is extremely unequal at the instant of recollison. We further show that the shift of the ion momentum corresponds to the change of the recollision time in the two-color laser field. By tuning the relative phase of the two-color components, the recollision time is controlled with attosecond precision.

  8. Wigner functions on non-standard symplectic vector spaces

    Science.gov (United States)

    Dias, Nuno Costa; Prata, João Nuno

    2018-01-01

    We consider the Weyl quantization on a flat non-standard symplectic vector space. We focus mainly on the properties of the Wigner functions defined therein. In particular we show that the sets of Wigner functions on distinct symplectic spaces are different but have non-empty intersections. This extends previous results to arbitrary dimension and arbitrary (constant) symplectic structure. As a by-product we introduce and prove several concepts and results on non-standard symplectic spaces which generalize those on the standard symplectic space, namely, the symplectic spectrum, Williamson's theorem, and Narcowich-Wigner spectra. We also show how Wigner functions on non-standard symplectic spaces behave under the action of an arbitrary linear coordinate transformation.

  9. Spherical complexes attached to symplectic lattices

    NARCIS (Netherlands)

    van der Kallen, W.L.J.; Looijenga, E.J.N.

    2011-01-01

    To the integral symplectic group Sp(2g, Z) we associate two posets of which we prove that they have the Cohen-Macaulay property. As an application we show that the locus of marked decomposable principally polarized abelian varieties in the Siegel space of genus g has the homotopy type of a bouquet

  10. Invariant metric for nonlinear symplectic maps

    Indian Academy of Sciences (India)

    In this paper, we construct an invariant metric in the space of homogeneous polynomials of a given degree (≥ 3). The homogeneous polynomials specify a nonlinear symplectic map which in turn represents a Hamiltonian system. By minimizing the norm constructed out of this metric as a function of system parameters, we ...

  11. Symplectic integrators with adaptive time steps

    Science.gov (United States)

    Richardson, A. S.; Finn, J. M.

    2012-01-01

    In recent decades, there have been many attempts to construct symplectic integrators with variable time steps, with rather disappointing results. In this paper, we identify the causes for this lack of performance, and find that they fall into two categories. In the first, the time step is considered a function of time alone, Δ = Δ(t). In this case, backward error analysis shows that while the algorithms remain symplectic, parametric instabilities may arise because of resonance between oscillations of Δ(t) and the orbital motion. In the second category the time step is a function of phase space variables Δ = Δ(q, p). In this case, the system of equations to be solved is analyzed by introducing a new time variable τ with dt = Δ(q, p) dτ. The transformed equations are no longer in Hamiltonian form, and thus do not benefit from integration methods which would be symplectic for Hamiltonian systems. We analyze two methods for integrating the transformed equations which do, however, preserve the structure of the original equations. The first is an extended phase space method, which has been successfully used in previous studies of adaptive time step symplectic integrators. The second, novel, method is based on a non-canonical mixed-variable generating function. Numerical trials for both of these methods show good results, without parametric instabilities or spurious growth or damping. It is then shown how to adapt the time step to an error estimate found by backward error analysis, in order to optimize the time-stepping scheme. Numerical results are obtained using this formulation and compared with other time-stepping schemes for the extended phase space symplectic method.

  12. Construction and functional characterization of double and triple mutants of parallel beta-bulge of ubiquitin.

    Science.gov (United States)

    Sharma, Mrinal; Prabha, C Ratna

    2011-12-01

    Ubiquitin, a small eukaryotic protein serving as a post-translational modification on many important proteins, plays central role in cellular homeostasis and cell cycle regulation. Ubiquitin features two beta-bulges, the second beta-bulge, located at the C-terminal region of the protein along with type II turn, holds 3 residues Glu64(1), Ser65(2) and Gln2(X). Percent frequency of occurrence of such a sequence in parallel beta-bulge is very low. However, the sequence and structure have been conserved in ubiquitin through out the evolution. Present study involves replacement of residues in unusual beta-bulge of ubiquitin by introducing mutations in combination through site directed mutagenesis, generating double and triple mutants and their functional characterization. Mutant ubiquitins cloned in yeast expression vector YEp96 tested for growth profile, viability assay and heat stress complementation study have revealed significant decrease in growth rate, loss of viability and non-complementation of heat sensitive phenotype with UbE64G-S65D and UbQ2N-E64G-S65D mutations. However, UbQ2N-S65D did not show any negative effects in the above assays. Present results show that, replacement of residues in beta-bulge of ubiquitin exerts severe effects on growth and viability in Saccharomyces cerevisiae due to functional failure of the mutant ubiquitins UbE64G-S65D and UbQ2N-E64G-S65D.

  13. Canonicalization and symplectic simulation of the gyrocenter dynamics in time-independent magnetic fields

    International Nuclear Information System (INIS)

    Zhang, Ruili; Tang, Yifa; Zhu, Beibei; Liu, Jian; Xiao, Jianyuan; Qin, Hong

    2014-01-01

    The gyrocenter dynamics of charged particles in time-independent magnetic fields is a non-canonical Hamiltonian system. The canonical description of the gyrocenter has both theoretical and practical importance. We provide a general procedure of the gyrocenter canonicalization, which is expressed by the series of a small variable ϵ depending only on the parallel velocity u and can be expressed in a recursive manner. We prove that the truncation of the series to any given order generates a set of exact canonical coordinates for a system, whose Lagrangian approximates to that of the original gyrocenter system in the same order. If flux surfaces exist for the magnetic field, the series stops simply at the second order and an exact canonical form of the gyrocenter system is obtained. With the canonicalization schemes, the canonical symplectic simulation of gyrocenter dynamics is realized for the first time. The canonical symplectic algorithm has the advantage of good conservation properties and long-term numerical accuracy, while avoiding numerical instability. It is worth mentioning that explicitly expressing the canonical Hamiltonian in new coordinates is usually difficult and impractical. We give an iteration procedure that is easy to implement in the original coordinates associated with the coordinate transformation. This is crucial for modern large-scale simulation studies in plasma physics. The dynamics of gyrocenters in the dipole magnetic field and in the toroidal geometry are simulated using the canonical symplectic algorithm by comparison with the higher-order non symplectic Runge-Kutta scheme. The overwhelming superiorities of the symplectic method for the gyrocenter system are evidently exhibited

  14. Birkhoffian Symplectic Scheme for a Quantum System

    International Nuclear Information System (INIS)

    Su Hongling

    2010-01-01

    In this paper, a classical system of ordinary differential equations is built to describe a kind of n-dimensional quantum systems. The absorption spectrum and the density of the states for the system are defined from the points of quantum view and classical view. From the Birkhoffian form of the equations, a Birkhoffian symplectic scheme is derived for solving n-dimensional equations by using the generating function method. Besides the Birkhoffian structure-preserving, the new scheme is proven to preserve the discrete local energy conservation law of the system with zero vector f. Some numerical experiments for a 3-dimensional example show that the new scheme can simulate the general Birkhoffian system better than the implicit midpoint scheme, which is well known to be symplectic scheme for Hamiltonian system. (general)

  15. Symplectic models for general insertion devices

    International Nuclear Information System (INIS)

    Wu, Y.; Forest, E.; Robin, D. S.; Nishimura, H.; Wolski, A.; Litvinenko, V. N.

    2001-01-01

    A variety of insertion devices (IDs), wigglers and undulators, linearly or elliptically polarized,are widely used as high brightness radiation sources at the modern light source rings. Long and high-field wigglers have also been proposed as the main source of radiation damping at next generation damping rings. As a result, it becomes increasingly important to understand the impact of IDs on the charged particle dynamics in the storage ring. In this paper, we report our recent development of a general explicit symplectic model for IDs with the paraxial ray approximation. High-order explicit symplectic integrators are developed to study real-world insertion devices with a number of wiggler harmonics and arbitrary polarizations

  16. Symplectic discretization for spectral element solution of Maxwell's equations

    International Nuclear Information System (INIS)

    Zhao Yanmin; Dai Guidong; Tang Yifa; Liu Qinghuo

    2009-01-01

    Applying the spectral element method (SEM) based on the Gauss-Lobatto-Legendre (GLL) polynomial to discretize Maxwell's equations, we obtain a Poisson system or a Poisson system with at most a perturbation. For the system, we prove that any symplectic partitioned Runge-Kutta (PRK) method preserves the Poisson structure and its implied symplectic structure. Numerical examples show the high accuracy of SEM and the benefit of conserving energy due to the use of symplectic methods.

  17. Quantum symplectic geometry. 1. The matrix Hamiltonian formalism

    International Nuclear Information System (INIS)

    Djemai, A.E.F.

    1994-07-01

    The main purpose of this work is to describe the quantum analogue of the usual classical symplectic geometry and then to formulate the quantum mechanics as a (quantum) non-commutative symplectic geometry. In this first part, we define the quantum symplectic structure in the context of the matrix differential geometry by using the discrete Weyl-Schwinger realization of the Heisenberg group. We also discuss the continuous limit and give an expression of the quantum structure constants. (author). 42 refs

  18. Chocolate flavanols and skin photoprotection: a parallel, double-blind, randomized clinical trial.

    Science.gov (United States)

    Mogollon, Jaime Andres; Boivin, Catherine; Lemieux, Simone; Blanchet, Claudine; Claveau, Joël; Dodin, Sylvie

    2014-06-27

    Solar ultraviolet (UV) radiation has deleterious effects on the skin, including sunburn, photoaging and cancer. Chocolate flavanols are naturally-occurring antioxidant and anti-inflammatory molecules that could play a role in preventing cutaneous UV damage. We investigated the influence of 12-week high-flavanol chocolate (HFC) consumption on skin sensitivity to UV radiation, measured by minimal erythema dose (MED). We also evaluated skin elasticity and hydration. In this 2-group, parallel, double-blind, randomized controlled trial, 74 women aged 20-65 years and Fitzpatrick skin phototypes I or II were recruited from the general community in Quebec City, for randomization to either HFC (n = 33) or low-flavanol chocolate (LFC) (n = 41). A blocked randomisation (4), considering date of entry, skin type and age as factors, generated a sequentially-numbered allocation list. Study participants and research assistants were blinded. Totally, 30 g of chocolate were consumed daily for 12 weeks, followed by a 3-week washout period. MED was assessed at baseline and at 6, 9, 12 and 15 weeks. Main outcome was changes in MED at week 12. 33 participants in the HFC group and 41 in the LFC group were analyzed with 15 weeks of follow-up. Both groups showed similarly-increased MED at 12 weeks (HFC: 0.0252 ± 0.1099 J/cm2 [mean ± standard deviation (SD)]; LFC: 0.0151 ± 0.1118; mean difference (MD): 0.0100 J/cm2; 95% confidence interval (CI): -0.0417 to 0.0618). However, after 3-week washout, the HFC group presented decreased MED (-0.0248 ± 0.1145) whereas no effect was seen in the LFC group (0.0168 ± 0.1698) (MD: -0.0417; 95% CI: -0.1106 to 0.0272). Net temple elasticity increased slightly but significantly by 0.09 ± 0.12 mm in the HFC group at 12 weeks compared to 0.02 ± 0.12 mm in the LFC group (MD: 0.06; 95% CI: 0.01 to 0.12 ). No significant adverse events were reported. Our study failed to demonstrate a statistically

  19. Chocolate flavanols and skin photoprotection: a parallel, double-blind, randomized clinical trial

    Science.gov (United States)

    2014-01-01

    Background Solar ultraviolet (UV) radiation has deleterious effects on the skin, including sunburn, photoaging and cancer. Chocolate flavanols are naturally-occurring antioxidant and anti-inflammatory molecules that could play a role in preventing cutaneous UV damage. We investigated the influence of 12-week high-flavanol chocolate (HFC) consumption on skin sensitivity to UV radiation, measured by minimal erythema dose (MED). We also evaluated skin elasticity and hydration. Methods In this 2-group, parallel, double-blind, randomized controlled trial, 74 women aged 20–65 years and Fitzpatrick skin phototypes I or II were recruited from the general community in Quebec City, for randomization to either HFC (n = 33) or low-flavanol chocolate (LFC) (n = 41). A blocked randomisation (4), considering date of entry, skin type and age as factors, generated a sequentially-numbered allocation list. Study participants and research assistants were blinded. Totally, 30 g of chocolate were consumed daily for 12 weeks, followed by a 3-week washout period. MED was assessed at baseline and at 6, 9, 12 and 15 weeks. Main outcome was changes in MED at week 12. Results 33 participants in the HFC group and 41 in the LFC group were analyzed with 15 weeks of follow-up. Both groups showed similarly-increased MED at 12 weeks (HFC: 0.0252 ± 0.1099 J/cm2 [mean ± standard deviation (SD)]; LFC: 0.0151 ± 0.1118; mean difference (MD): 0.0100 J/cm2; 95% confidence interval (CI): -0.0417 to 0.0618). However, after 3-week washout, the HFC group presented decreased MED (-0.0248 ± 0.1145) whereas no effect was seen in the LFC group (0.0168 ± 0.1698) (MD: -0.0417; 95% CI: -0.1106 to 0.0272). Net temple elasticity increased slightly but significantly by 0.09 ± 0.12 mm in the HFC group at 12 weeks compared to 0.02 ± 0.12 mm in the LFC group (MD: 0.06; 95% CI: 0.01 to 0.12 ). No significant adverse events were reported. Conclusion Our study failed to

  20. Stochastic deformation of a thermodynamic symplectic structure

    OpenAIRE

    Kazinski, P. O.

    2008-01-01

    A stochastic deformation of a thermodynamic symplectic structure is studied. The stochastic deformation procedure is analogous to the deformation of an algebra of observables like deformation quantization, but for an imaginary deformation parameter (the Planck constant). Gauge symmetries of thermodynamics and corresponding stochastic mechanics, which describes fluctuations of a thermodynamic system, are revealed and gauge fields are introduced. A physical interpretation to the gauge transform...

  1. Symplectic and Poisson Geometry in Interaction with Analysis, Algebra and Topology & Symplectic Geometry, Noncommutative Geometry and Physics

    CERN Document Server

    Eliashberg, Yakov; Maeda, Yoshiaki; Symplectic, Poisson, and Noncommutative geometry

    2014-01-01

    Symplectic geometry originated in physics, but it has flourished as an independent subject in mathematics, together with its offspring, symplectic topology. Symplectic methods have even been applied back to mathematical physics. Noncommutative geometry has developed an alternative mathematical quantization scheme based on a geometric approach to operator algebras. Deformation quantization, a blend of symplectic methods and noncommutative geometry, approaches quantum mechanics from a more algebraic viewpoint, as it addresses quantization as a deformation of Poisson structures. This volume contains seven chapters based on lectures given by invited speakers at two May 2010 workshops held at the Mathematical Sciences Research Institute: Symplectic and Poisson Geometry in Interaction with Analysis, Algebra and Topology (honoring Alan Weinstein, one of the key figures in the field) and Symplectic Geometry, Noncommutative Geometry and Physics. The chapters include presentations of previously unpublished results and ...

  2. Research on out-phase oscillation in a nuclear-coupled parallel double-channel boiling system

    International Nuclear Information System (INIS)

    Zhou Linglan; Zhang Hong; Liu Yu; Zang Xi'nian

    2011-01-01

    In this paper, the RELAP5 thermal-hydraulic system code is coupled with the TDOT-T 3D neutron kinetic code by PVM (Parallel Virtual Machine). A parallel double-channel boiling system is built by the coupled code and the instability boundary of out-of-phase oscillation in the system is obtained. The effects of axis power distribution and neutron feedback on the out-of-phase oscillation are analyzed in details. It is found that there are type-Ⅰ and type-Ⅱ density wave oscillation regions when the axial power peak is located at upstream of the heating section. At relatively lower values of fuel time constant, the neutron feedback always delays both types of density wave oscillations. (authors)

  3. Smooth Maps of a Foliated Manifold in a Symplectic Manifold

    Indian Academy of Sciences (India)

    Let be a smooth manifold with a regular foliation F and a 2-form which induces closed forms on the leaves of F in the leaf topology. A smooth map f : ( M , F ) ⟶ ( N , ) in a symplectic manifold ( N , ) is called a foliated symplectic immersion if restricts to an immersion on each leaf of the foliation and further, the ...

  4. The difficulty of symplectic analysis with second class systems

    International Nuclear Information System (INIS)

    Shirzad, A.; Mojiri, M.

    2005-01-01

    Using the basic concepts of the chain by chain method we show that the symplectic analysis, which was claimed to be equivalent to the usual Dirac method, fails when second class constraints are present. We propose a modification in symplectic analysis that solves the problem

  5. The Maslov index in weak symplectic functional analysis

    DEFF Research Database (Denmark)

    Booss-Bavnbek, Bernhelm; Zhu, Chaofeng

    2013-01-01

    We recall the Chernoff-Marsden definition of weak symplectic structure and give a rigorous treatment of the functional analysis and geometry of weak symplectic Banach spaces. We define the Maslov index of a continuous path of Fredholm pairs of Lagrangian subspaces in continuously varying Banach...

  6. Conformal transformation and symplectic structure of self-dual fields

    International Nuclear Information System (INIS)

    Yang Kongqing; Luo Yan

    1996-01-01

    Considered two dimensional self-dual fields, the symplectic structure on the space of solutions is given. It is shown that this structure is Poincare invariant. The Lagrangian of two dimensional self-dual field is invariant under infinite one component conformal group, then this symplectic structure is also invariant under this conformal group. The conserved currents in geometrical formalism are also obtained

  7. Lorentz covariant canonical symplectic algorithms for dynamics of charged particles

    Science.gov (United States)

    Wang, Yulei; Liu, Jian; Qin, Hong

    2016-12-01

    In this paper, the Lorentz covariance of algorithms is introduced. Under Lorentz transformation, both the form and performance of a Lorentz covariant algorithm are invariant. To acquire the advantages of symplectic algorithms and Lorentz covariance, a general procedure for constructing Lorentz covariant canonical symplectic algorithms (LCCSAs) is provided, based on which an explicit LCCSA for dynamics of relativistic charged particles is built. LCCSA possesses Lorentz invariance as well as long-term numerical accuracy and stability, due to the preservation of a discrete symplectic structure and the Lorentz symmetry of the system. For situations with time-dependent electromagnetic fields, which are difficult to handle in traditional construction procedures of symplectic algorithms, LCCSA provides a perfect explicit canonical symplectic solution by implementing the discretization in 4-spacetime. We also show that LCCSA has built-in energy-based adaptive time steps, which can optimize the computation performance when the Lorentz factor varies.

  8. Large-scale parallel configuration interaction. II. Two- and four-component double-group general active space implementation with application to BiH

    DEFF Research Database (Denmark)

    Knecht, Stefan; Jensen, Hans Jørgen Aagaard; Fleig, Timo

    2010-01-01

    We present a parallel implementation of a large-scale relativistic double-group configuration interaction CIprogram. It is applicable with a large variety of two- and four-component Hamiltonians. The parallel algorithm is based on a distributed data model in combination with a static load balanci...

  9. A symplectic framework for field theories

    International Nuclear Information System (INIS)

    Kijowski, J.; Tulczyjew, W.M.

    1979-01-01

    These notes are concerned with the formulation of a new conceptual framework for classical field theories. Although the formulation is based on fairly advanced concepts of symplectic geometry these notes cannot be viewed as a reformulation of known structures in more rigorous and elegant torns. Our intention is rather to communicate to theoretical physicists a set of new physical ideas. We have chosen for this purpose the language of local coordinates which is more elementary and more widely known than the abstract language of modern differntial geometry. Our emphasis is directed more to physical intentions than to mathematical vigour. We start with a symplectic analysis of staties. Both discrete and continuous systems are considered on a largely intuitive level. The notion of reciprocity and potentiality of the theory is discussed. Chapter II is a presentation of particle dynamics together with more rigorous definitions of the geometric structure. Lagrangian-Submanifolds and their generating function 3 are defined and the time evolution of particle states is studied. Chapter II form the main part of these notes. Here we describe the construction of canonical momenta and discuss the field dynamics in finite domains of space-time. We also establish the relation between our symplectic framework and the geometric formulation of the calculus of variations of multiple integrals. In the following chapter we give a few examples of field theories selected to illustrate various features of the new approach. A new formulation of the theory of gravity consists of using the affine connection in space-time as the field configuration. In the past section we present an analysis of hydrodynamics within our framework which reveals a formal analogy with electrodynamics. The discovery of potentials for hydrodynamics and the subsequent formulation of a variational principle provides an excellent example for the fruitfulness of the new approach to field theory. A short review of

  10. Higher-order force gradient symplectic algorithms

    Science.gov (United States)

    Chin, Siu A.; Kidwell, Donald W.

    2000-12-01

    We show that a recently discovered fourth order symplectic algorithm, which requires one evaluation of force gradient in addition to three evaluations of the force, when iterated to higher order, yielded algorithms that are far superior to similarly iterated higher order algorithms based on the standard Forest-Ruth algorithm. We gauge the accuracy of each algorithm by comparing the step-size independent error functions associated with energy conservation and the rotation of the Laplace-Runge-Lenz vector when solving a highly eccentric Kepler problem. For orders 6, 8, 10, and 12, the new algorithms are approximately a factor of 103, 104, 104, and 105 better.

  11. On Non-Abelian Symplectic Cutting

    DEFF Research Database (Denmark)

    Martens, Johan; Thaddeus, Michael

    2012-01-01

    We discuss symplectic cutting for Hamiltonian actions of non-Abelian compact groups. By using a degeneration based on the Vinberg monoid we give, in good cases, a global quotient description of a surgery construction introduced by Woodward and Meinrenken, and show it can be interpreted in algebro......-geometric terms. A key ingredient is the `universal cut' of the cotangent bundle of the group itself, which is identified with a moduli space of framed bundles on chains of projective lines recently introduced by the authors....

  12. Debye length dependence of the anomalous dynamics of ionic double layers in a parallel plate capacitor

    NARCIS (Netherlands)

    Kortschot, R. J.; Philipse, A. P.; Erné, B. H.

    2014-01-01

    The electrical impedance spectrum of simple ionic solutions is measured in a parallel plate capacitor at small applied ac voltage. The influence of the ionic strength is investigated using several electrolytes at different concentrations in solvents of different dielectric constants. The electric

  13. Parallel double-plate capacitive proximity sensor modelling based on effective theory

    International Nuclear Information System (INIS)

    Li, Nan; Zhu, Haiye; Wang, Wenyu; Gong, Yu

    2014-01-01

    A semi-analytical model for a double-plate capacitive proximity sensor is presented according to the effective theory. Three physical models are established to derive the final equation of the sensor. Measured data are used to determine the coefficients. The final equation is verified by using measured data. The average relative error of the calculated and the measured sensor capacitance is less than 7.5%. The equation can be used to provide guidance to engineering design of the proximity sensors

  14. Time-dependent resonant tunnelling for parallel-coupled double quantum dots

    International Nuclear Information System (INIS)

    Dong Bing; Djuric, Ivana; Cui, H L; Lei, X L

    2004-01-01

    We derive the quantum rate equations for an Aharonov-Bohm interferometer with two vertically coupled quantum dots embedded in each of two arms by means of the nonequilibrium Green function in the sequential tunnelling regime. Based on these equations, we investigate time-dependent resonant tunnelling under a small amplitude irradiation and find that the resonant photon-assisted tunnelling peaks in photocurrent demonstrate a combination behaviour of Fano and Lorentzian resonances due to the interference effect between the two pathways in this parallel configuration, which is controllable by threading the magnetic flux inside this device

  15. Symplectic invariants, entropic measures and correlations of Gaussian states

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, Alessio; Illuminati, Fabrizio; Siena, Silvio De [Dipartimento di Fisica ' E R Caianiello' , Universita di Salerno, INFM UdR Salerno, INFN Sezione di Napoli, Gruppo Collegato di Salerno, Via S Allende, 84081 Baronissi, SA (Italy)

    2004-01-28

    We present a derivation of the Von Neumann entropy and mutual information of arbitrary two-mode Gaussian states, based on the explicit determination of the symplectic eigenvalues of a generic covariance matrix. The key role of the symplectic invariants in such a determination is pointed out. We show that the Von Neumann entropy depends on two symplectic invariants, while the purity (or the linear entropy) is determined by only one invariant, so that the two quantities provide two different hierarchies of mixed Gaussian states. A comparison between mutual information and entanglement of formation for symmetric states is considered, taking note of the crucial role of the symplectic eigenvalues in qualifying and quantifying the correlations present in a generic state. (letter to the editor)

  16. Symplectic invariants, entropic measures and correlations of Gaussian states

    International Nuclear Information System (INIS)

    Serafini, Alessio; Illuminati, Fabrizio; Siena, Silvio De

    2004-01-01

    We present a derivation of the Von Neumann entropy and mutual information of arbitrary two-mode Gaussian states, based on the explicit determination of the symplectic eigenvalues of a generic covariance matrix. The key role of the symplectic invariants in such a determination is pointed out. We show that the Von Neumann entropy depends on two symplectic invariants, while the purity (or the linear entropy) is determined by only one invariant, so that the two quantities provide two different hierarchies of mixed Gaussian states. A comparison between mutual information and entanglement of formation for symmetric states is considered, taking note of the crucial role of the symplectic eigenvalues in qualifying and quantifying the correlations present in a generic state. (letter to the editor)

  17. The GL(1 vertical stroke 1)-symplectic fermion correspondence

    International Nuclear Information System (INIS)

    Creutzig, Thomas; Roenne, Peter B.

    2008-12-01

    In this note we prove a correspondence between the Wess-Zumino-Novikov-Witten model of the Lie supergroup GL(1 vertical stroke 1) and a free model consisting of two scalars and a pair of symplectic fermions. This model was discussed earlier by LeClair. Vertex operators for the symplectic fermions include twist fields, and correlation functions of GL(1 vertical stroke 1) agree with the known results for the scalars and symplectic fermions. We perform a detailed study of boundary states for symplectic fermions and apply them to branes in GL(1 vertical stroke 1). This allows us to compute new amplitudes of strings stretching between branes of different types and confirming Cardy's condition. (orig.)

  18. The GL(1 vertical stroke 1)-symplectic fermion correspondence

    Energy Technology Data Exchange (ETDEWEB)

    Creutzig, Thomas; Roenne, Peter B.

    2008-12-15

    In this note we prove a correspondence between the Wess-Zumino-Novikov-Witten model of the Lie supergroup GL(1 vertical stroke 1) and a free model consisting of two scalars and a pair of symplectic fermions. This model was discussed earlier by LeClair. Vertex operators for the symplectic fermions include twist fields, and correlation functions of GL(1 vertical stroke 1) agree with the known results for the scalars and symplectic fermions. We perform a detailed study of boundary states for symplectic fermions and apply them to branes in GL(1 vertical stroke 1). This allows us to compute new amplitudes of strings stretching between branes of different types and confirming Cardy's condition. (orig.)

  19. Transversity results and computations in symplectic field theory

    International Nuclear Information System (INIS)

    Fabert, Oliver

    2008-01-01

    Although the definition of symplectic field theory suggests that one has to count holomorphic curves in cylindrical manifolds R x V equipped with a cylindrical almost complex structure J, it is already well-known from Gromov-Witten theory that, due to the presence of multiply-covered curves, we in general cannot achieve transversality for all moduli spaces even for generic choices of J. In this thesis we treat the transversality problem of symplectic field theory in two important cases. In the first part of this thesis we are concerned with the rational symplectic field theory of Hamiltonian mapping tori, which is also called the Floer case. For this observe that in the general geometric setup for symplectic field theory, the contact manifolds can be replaced by mapping tori M φ of symplectic manifolds (M,ω M ) with symplectomorphisms φ. While the cylindrical contact homology of M φ is given by the Floer homologies of powers of φ, the other algebraic invariants of symplectic field theory for M φ provide natural generalizations of symplectic Floer homology. For symplectically aspherical M and Hamiltonian φ we study the moduli spaces of rational curves and prove a transversality result, which does not need the polyfold theory by Hofer, Wysocki and Zehnder and allows us to compute the full contact homology of M φ ≅ S 1 x M. The second part of this thesis is devoted to the branched covers of trivial cylinders over closed Reeb orbits, which are the trivial examples of punctured holomorphic curves studied in rational symplectic field theory. Since all moduli spaces of trivial curves with virtual dimension one cannot be regular, we use obstruction bundles in order to find compact perturbations making the Cauchy-Riemann operator transversal to the zero section and show that the algebraic count of elements in the resulting regular moduli spaces is zero. Once the analytical foundations of symplectic field theory are established, our result implies that the

  20. Transversity results and computations in symplectic field theory

    Energy Technology Data Exchange (ETDEWEB)

    Fabert, Oliver

    2008-02-21

    Although the definition of symplectic field theory suggests that one has to count holomorphic curves in cylindrical manifolds R x V equipped with a cylindrical almost complex structure J, it is already well-known from Gromov-Witten theory that, due to the presence of multiply-covered curves, we in general cannot achieve transversality for all moduli spaces even for generic choices of J. In this thesis we treat the transversality problem of symplectic field theory in two important cases. In the first part of this thesis we are concerned with the rational symplectic field theory of Hamiltonian mapping tori, which is also called the Floer case. For this observe that in the general geometric setup for symplectic field theory, the contact manifolds can be replaced by mapping tori M{sub {phi}} of symplectic manifolds (M,{omega}{sub M}) with symplectomorphisms {phi}. While the cylindrical contact homology of M{sub {phi}} is given by the Floer homologies of powers of {phi}, the other algebraic invariants of symplectic field theory for M{sub {phi}} provide natural generalizations of symplectic Floer homology. For symplectically aspherical M and Hamiltonian {phi} we study the moduli spaces of rational curves and prove a transversality result, which does not need the polyfold theory by Hofer, Wysocki and Zehnder and allows us to compute the full contact homology of M{sub {phi}} {approx_equal} S{sup 1} x M. The second part of this thesis is devoted to the branched covers of trivial cylinders over closed Reeb orbits, which are the trivial examples of punctured holomorphic curves studied in rational symplectic field theory. Since all moduli spaces of trivial curves with virtual dimension one cannot be regular, we use obstruction bundles in order to find compact perturbations making the Cauchy-Riemann operator transversal to the zero section and show that the algebraic count of elements in the resulting regular moduli spaces is zero. Once the analytical foundations of symplectic

  1. Fedosov’s formal symplectic groupoids and contravariant connections

    Science.gov (United States)

    Karabegov, Alexander V.

    2006-10-01

    Using Fedosov's approach we give a geometric construction of a formal symplectic groupoid over any Poisson manifold endowed with a torsion-free Poisson contravariant connection. In the case of Kähler-Poisson manifolds this construction provides, in particular, the formal symplectic groupoids with separation of variables. We show that the dual of a semisimple Lie algebra does not admit torsion-free Poisson contravariant connections.

  2. Smooth maps of a foliated manifold in a symplectic manifold

    Indian Academy of Sciences (India)

    Abstract. Let M be a smooth manifold with a regular foliation F and a 2-form ω which induces closed forms on the leaves of F in the leaf topology. A smooth map f : (M, F) −→ (N,σ) in a symplectic manifold (N,σ) is called a foliated symplectic immersion if f restricts to an immersion on each leaf of the foliation and further, the.

  3. Double random phase spread spectrum spread space technique for secure parallel optical multiplexing with individual encryption key

    Science.gov (United States)

    Hennelly, B. M.; Javidi, B.; Sheridan, J. T.

    2005-09-01

    A number of methods have been recently proposed in the literature for the encryption of 2-D information using linear optical systems. In particular the double random phase encoding system has received widespread attention. This system uses two Random Phase Keys (RPK) positioned in the input spatial domain and the spatial frequency domain and if these random phases are described by statistically independent white noises then the encrypted image can be shown to be a white noise. Decryption only requires knowledge of the RPK in the frequency domain. The RPK may be implemented using a Spatial Light Modulators (SLM). In this paper we propose and investigate the use of SLMs for secure optical multiplexing. We show that in this case it is possible to encrypt multiple images in parallel and multiplex them for transmission or storage. The signal energy is effectively spread in the spatial frequency domain. As expected the number of images that can be multiplexed together and recovered without loss is proportional to the ratio of the input image and the SLM resolution. Many more images may be multiplexed with some loss in recovery. Furthermore each individual encryption is more robust than traditional double random phase encoding since decryption requires knowledge of both RPK and a lowpass filter in order to despread the spectrum and decrypt the image. Numerical simulations are presented and discussed.

  4. Wideband and flat-gain amplifier based on high concentration erbium-doped fibres in parallel double-pass configuration

    International Nuclear Information System (INIS)

    Hamida, B A; Cheng, X S; Harun, S W; Naji, A W; Arof, H; Al-Khateeb, W; Khan, S; Ahmad, H

    2012-01-01

    A wideband and flat gain erbium-doped fibre amplifier (EDFA) is demonstrated using a hybrid gain medium of a zirconiabased erbium-doped fibre (Zr-EDF) and a high concentration erbium-doped fibre (EDF). The amplifier has two stages comprising a 2-m-long ZEDF and 9-m-long EDF optimised for C- and L-band operations, respectively, in a double-pass parallel configuration. A chirp fibre Bragg grating (CFBG) is used in both stages to ensure double propagation of the signal and thus to increase the attainable gain in both C- and L-band regions. At an input signal power of 0 dBm, a flat gain of 15 dB is achieved with a gain variation of less than 0.5 dB within a wide wavelength range from 1530 to 1605 nm. The corresponding noise figure varies from 6.2 to 10.8 dB within this wavelength region.

  5. Stem thrust prediction model for W-K-M double wedge parallel expanding gate valves

    Energy Technology Data Exchange (ETDEWEB)

    Eldiwany, B.; Alvarez, P.D. [Kalsi Engineering Inc., Sugar Land, TX (United States); Wolfe, K. [Electric Power Research Institute, Palo Alto, CA (United States)

    1996-12-01

    An analytical model for determining the required valve stem thrust during opening and closing strokes of W-K-M parallel expanding gate valves was developed as part of the EPRI Motor-Operated Valve Performance Prediction Methodology (EPRI MOV PPM) Program. The model was validated against measured stem thrust data obtained from in-situ testing of three W-K-M valves. Model predictions show favorable, bounding agreement with the measured data for valves with Stellite 6 hardfacing on the disks and seat rings for water flow in the preferred flow direction (gate downstream). The maximum required thrust to open and to close the valve (excluding wedging and unwedging forces) occurs at a slightly open position and not at the fully closed position. In the nonpreferred flow direction, the model shows that premature wedging can occur during {Delta}P closure strokes even when the coefficients of friction at different sliding surfaces are within the typical range. This paper summarizes the model description and comparison against test data.

  6. Stem thrust prediction model for W-K-M double wedge parallel expanding gate valves

    International Nuclear Information System (INIS)

    Eldiwany, B.; Alvarez, P.D.; Wolfe, K.

    1996-01-01

    An analytical model for determining the required valve stem thrust during opening and closing strokes of W-K-M parallel expanding gate valves was developed as part of the EPRI Motor-Operated Valve Performance Prediction Methodology (EPRI MOV PPM) Program. The model was validated against measured stem thrust data obtained from in-situ testing of three W-K-M valves. Model predictions show favorable, bounding agreement with the measured data for valves with Stellite 6 hardfacing on the disks and seat rings for water flow in the preferred flow direction (gate downstream). The maximum required thrust to open and to close the valve (excluding wedging and unwedging forces) occurs at a slightly open position and not at the fully closed position. In the nonpreferred flow direction, the model shows that premature wedging can occur during ΔP closure strokes even when the coefficients of friction at different sliding surfaces are within the typical range. This paper summarizes the model description and comparison against test data

  7. Metalenses based on the non-parallel double-slit arrays

    Science.gov (United States)

    Shao, Hongyan; Chen, Chen; Wang, Jicheng; Pan, Liang; Sang, Tian

    2017-09-01

    Metalenses based on surface plasmon polaritons have played an indispensable role in ultra-thin devices designing. The amplitude, phase and polarization of electromagnetic waves all can be controlled easily by modifying the metasurface structures. Here we propose and investigate a new type of structure with Babinet-inverted nano-antennas which can provide a series of unit-cells with phase-shifts covering 2π and ensure almost same transmittance simultaneously. As a result, the wavefront can be manipulated by arraying the units in course. Metalenses with the linear asymmetrical double slit unit-cell arrays are designed and the simulative results exhibit their perfect focusing characteristics, including single-focus lenses and multi-focus lenses. The small focus size and high numerical aperture make them stand out from the traditional counterparts in application of precision sensing devices. We expect our designs will provide new insights in the practical applications for metasurfaces in data storages, optical information processing and optical holography.

  8. Symmetries of the Space of Linear Symplectic Connections

    Science.gov (United States)

    Fox, Daniel J. F.

    2017-01-01

    There is constructed a family of Lie algebras that act in a Hamiltonian way on the symplectic affine space of linear symplectic connections on a symplectic manifold. The associated equivariant moment map is a formal sum of the Cahen-Gutt moment map, the Ricci tensor, and a translational term. The critical points of a functional constructed from it interpolate between the equations for preferred symplectic connections and the equations for critical symplectic connections. The commutative algebra of formal sums of symmetric tensors on a symplectic manifold carries a pair of compatible Poisson structures, one induced from the canonical Poisson bracket on the space of functions on the cotangent bundle polynomial in the fibers, and the other induced from the algebraic fiberwise Schouten bracket on the symmetric algebra of each fiber of the cotangent bundle. These structures are shown to be compatible, and the required Lie algebras are constructed as central extensions of their! linear combinations restricted to formal sums of symmetric tensors whose first order term is a multiple of the differential of its zeroth order term.

  9. A modified symplectic PRK scheme for seismic wave modeling

    Science.gov (United States)

    Liu, Shaolin; Yang, Dinghui; Ma, Jian

    2017-02-01

    A new scheme for the temporal discretization of the seismic wave equation is constructed based on symplectic geometric theory and a modified strategy. The ordinary differential equation in terms of time, which is obtained after spatial discretization via the spectral-element method, is transformed into a Hamiltonian system. A symplectic partitioned Runge-Kutta (PRK) scheme is used to solve the Hamiltonian system. A term related to the multiplication of the spatial discretization operator with the seismic wave velocity vector is added into the symplectic PRK scheme to create a modified symplectic PRK scheme. The symplectic coefficients of the new scheme are determined via Taylor series expansion. The positive coefficients of the scheme indicate that its long-term computational capability is more powerful than that of conventional symplectic schemes. An exhaustive theoretical analysis reveals that the new scheme is highly stable and has low numerical dispersion. The results of three numerical experiments demonstrate the high efficiency of this method for seismic wave modeling.

  10. Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol.

    Science.gov (United States)

    Martí, M L; De los Santos, A R; Di Girolamo, G; Gil, M; Manero, E O; Fraga, C

    1993-01-01

    Lysine clonixinate (LC), an effective and well tolerated non-morphinic analgesic whose mechanism of action is basically due to the inhibition of cyclo-oxygenase, was assessed with a double-blind randomized dummy design versus paracetamol (P) on 200 patients suffering from pain after minor dental surgery. Patients received according to their needs 1 or 2 tablets of 125 mg lysine clonixinate or 500 mg paracetamol every 8 h during 48 h or until pain relief. Both groups, each composed of 100 patients, were comparable in terms of demographic conditions (t test), initial symptoms (chi-square test), characteristics of the extracted dental pieces, surgical complications and wound treatment (chi-square test). Pain intensity scores and daily average intake of tablets (3.4/day) documented in the patients' diary revealed no statistically significant differences between the two treatments (chi-square test). It was found that spontaneous pain measured using a visual analogue scale (VAS) decreased significantly in both treatment groups at the 24-h control examination. The following values were observed in the LC group: baseline 4.38 +/- 1.7; 24-h * 1.20 +/- 1.4; 48-h * 0.36 +/- 1.2. In the P group the values were: baseline 4.28 +/- 1.6; 24-h * 1.11 +/- 1.4; 48-h * 0.30 +/- 0.7 (*p < 0.05). Other variables like facial swelling and night pain, evaluated on a score from 0 to 4 and symptom presence or absence respectively, showed a similar response.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. Poisson traces, D-modules, and symplectic resolutions.

    Science.gov (United States)

    Etingof, Pavel; Schedler, Travis

    2018-01-01

    We survey the theory of Poisson traces (or zeroth Poisson homology) developed by the authors in a series of recent papers. The goal is to understand this subtle invariant of (singular) Poisson varieties, conditions for it to be finite-dimensional, its relationship to the geometry and topology of symplectic resolutions, and its applications to quantizations. The main technique is the study of a canonical D-module on the variety. In the case the variety has finitely many symplectic leaves (such as for symplectic singularities and Hamiltonian reductions of symplectic vector spaces by reductive groups), the D-module is holonomic, and hence, the space of Poisson traces is finite-dimensional. As an application, there are finitely many irreducible finite-dimensional representations of every quantization of the variety. Conjecturally, the D-module is the pushforward of the canonical D-module under every symplectic resolution of singularities, which implies that the space of Poisson traces is dual to the top cohomology of the resolution. We explain many examples where the conjecture is proved, such as symmetric powers of du Val singularities and symplectic surfaces and Slodowy slices in the nilpotent cone of a semisimple Lie algebra. We compute the D-module in the case of surfaces with isolated singularities and show it is not always semisimple. We also explain generalizations to arbitrary Lie algebras of vector fields, connections to the Bernstein-Sato polynomial, relations to two-variable special polynomials such as Kostka polynomials and Tutte polynomials, and a conjectural relationship with deformations of symplectic resolutions. In the appendix we give a brief recollection of the theory of D-modules on singular varieties that we require.

  12. Poisson traces, D-modules, and symplectic resolutions

    Science.gov (United States)

    Etingof, Pavel; Schedler, Travis

    2018-03-01

    We survey the theory of Poisson traces (or zeroth Poisson homology) developed by the authors in a series of recent papers. The goal is to understand this subtle invariant of (singular) Poisson varieties, conditions for it to be finite-dimensional, its relationship to the geometry and topology of symplectic resolutions, and its applications to quantizations. The main technique is the study of a canonical D-module on the variety. In the case the variety has finitely many symplectic leaves (such as for symplectic singularities and Hamiltonian reductions of symplectic vector spaces by reductive groups), the D-module is holonomic, and hence, the space of Poisson traces is finite-dimensional. As an application, there are finitely many irreducible finite-dimensional representations of every quantization of the variety. Conjecturally, the D-module is the pushforward of the canonical D-module under every symplectic resolution of singularities, which implies that the space of Poisson traces is dual to the top cohomology of the resolution. We explain many examples where the conjecture is proved, such as symmetric powers of du Val singularities and symplectic surfaces and Slodowy slices in the nilpotent cone of a semisimple Lie algebra. We compute the D-module in the case of surfaces with isolated singularities and show it is not always semisimple. We also explain generalizations to arbitrary Lie algebras of vector fields, connections to the Bernstein-Sato polynomial, relations to two-variable special polynomials such as Kostka polynomials and Tutte polynomials, and a conjectural relationship with deformations of symplectic resolutions. In the appendix we give a brief recollection of the theory of D-modules on singular varieties that we require.

  13. A symplectic coherent beam-beam model

    International Nuclear Information System (INIS)

    Furman, M.A.

    1989-05-01

    We consider a simple one-dimensional model to study the effects of the beam-beam force on the coherent dynamics of colliding beams. The key ingredient is a linearized beam-beam kick. We study only the quadrupole modes, with the dynamical variables being the 2nd-order moments of the canonical variables q, p. Our model is self-consistent in the sense that no higher order moments are generated by the linearized beam-beam kicks, and that the only source of violation of symplecticity is the radiation. We discuss the round beam case only, in which vertical and horizontal quantities are assumed to be equal (though they may be different in the two beams). Depending on the values of the tune and beam intensity, we observe steady states in which otherwise identical bunches have sizes that are equal, or unequal, or periodic, or behave chaotically from turn to turn. Possible implications of luminosity saturation with increasing beam intensity are discussed. Finally, we present some preliminary applications to an asymmetric collider. 8 refs., 8 figs

  14. A symplectic integration method for elastic filaments

    Science.gov (United States)

    Ladd, Tony; Misra, Gaurav

    2009-03-01

    Elastic rods are a ubiquitous coarse-grained model of semi-flexible biopolymers such as DNA, actin, and microtubules. The Worm-Like Chain (WLC) is the standard numerical model for semi-flexible polymers, but it is only a linearized approximation to the dynamics of an elastic rod, valid for small deflections; typically the torsional motion is neglected as well. In the standard finite-difference and finite-element formulations of an elastic rod, the continuum equations of motion are discretized in space and time, but it is then difficult to ensure that the Hamiltonian structure of the exact equations is preserved. Here we discretize the Hamiltonian itself, expressed as a line integral over the contour of the filament. This discrete representation of the continuum filament can then be integrated by one of the explicit symplectic integrators frequently used in molecular dynamics. The model systematically approximates the continuum partial differential equations, but has the same level of computational complexity as molecular dynamics and is constraint free. Numerical tests show that the algorithm is much more stable than a finite-difference formulation and can be used for high aspect ratio filaments, such as actin. We present numerical results for the deterministic and stochastic motion of single filaments.

  15. Iodixanol in cerebral computed tomography: a randomized, double-blind, phase-III, parallel study with iodixanol and iohexol

    International Nuclear Information System (INIS)

    Doerfler, A.; Wanke, I.; Forsting, M.; Fiebach, J.; Sartor, K.; Henseke, P.

    1999-01-01

    Iodixanol is a new nonionic dimer, isotonic with blood at all clinically relevant concentrations. Iodixanol (270 mg I/ml) was compared in a double-blind, randomized, parallel-group, phase-III study to the monomeric nonionic iohexol (300 mg I/ml) for evaluation of safety, tolerability and radiographic efficacy during cerebral CT. One hundred adult patients scheduled to undergo contrast-enhanced cerebral CT were randomly allocated to receive either iodixanol or iohexol. All completed the trial. Safety was evaluated by recording discomfort and other adverse events, tolerance by assessing intensity and incidence of discomfort. Radiographic efficacy was assessed from the diagnostic information and the radiographic density. No serious adverse events occurred. One patient (2 %) in the iodixanol group and one patient (2 %) in the iohexol group experienced a transient reddening at the neck and lower neck-line, respectively. Both contrast agents were well tolerated. One patient (2 %) in the iodixanol group and two patients (4 %) in the iohexol group experienced a sensation of warmth (discomfort) in connection with the injection. No difference between the two contrast media were noted radiographically. This comparison between iodixanol and iohexol showed both contrast media to be safe, well-tolerated and efficacious for use in cerebral CT. (orig.)

  16. Double-blind, parallel-group evaluation of etodolac and naproxen in patients with acute sports injuries.

    Science.gov (United States)

    D'Hooghe, M

    1992-01-01

    The efficacy and safety of etodolac and naproxen were compared in a double-blind, randomized, parallel-group outpatient study. Patients with acute sports injuries were assigned to receive either etodolac 300 mg TID (50 patients) or naproxen 500 mg BID (49 patients) for up to 7 days. Assessments were made at the pretreatment screening (baseline) and at days 2, 3, 4, and 7 of treatment. Assessments included patient and physician global evaluations, spontaneous and induced pain intensity, range of motion, tenderness, heat, degree of swelling, and degree of erythema. Safety assessments, including laboratory profiles, were made at pretreatment and at final evaluation; patients' complaints were elicited at all visits. Both treatment groups showed significant (P less than or equal to 0.05) improvement from baseline for all efficacy parameters by day 2 and thereafter at all time points. Improvement was similar for the two groups. No patients in either group withdrew from the study because of drug-related adverse reactions. The results of this study indicate that etodolac (900 mg/day) is effective and well tolerated as an analgesic and anti-inflammatory in acute sports injuries and is comparable to naproxen (1000 mg/day).

  17. Free and constrained symplectic integrators for numerical general relativity

    International Nuclear Information System (INIS)

    Richter, Ronny; Lubich, Christian

    2008-01-01

    We consider symplectic time integrators in numerical general relativity and discuss both free and constrained evolution schemes. For free evolution of ADM-like equations we propose the use of the Stoermer-Verlet method, a standard symplectic integrator which here is explicit in the computationally expensive curvature terms. For the constrained evolution we give a formulation of the evolution equations that enforces the momentum constraints in a holonomically constrained Hamiltonian system and turns the Hamilton constraint function from a weak to a strong invariant of the system. This formulation permits the use of the constraint-preserving symplectic RATTLE integrator, a constrained version of the Stoermer-Verlet method. The behavior of the methods is illustrated on two effectively (1+1)-dimensional versions of Einstein's equations, which allow us to investigate a perturbed Minkowski problem and the Schwarzschild spacetime. We compare symplectic and non-symplectic integrators for free evolution, showing very different numerical behavior for nearly-conserved quantities in the perturbed Minkowski problem. Further we compare free and constrained evolution, demonstrating in our examples that enforcing the momentum constraints can turn an unstable free evolution into a stable constrained evolution. This is demonstrated in the stabilization of a perturbed Minkowski problem with Dirac gauge, and in the suppression of the propagation of boundary instabilities into the interior of the domain in Schwarzschild spacetime

  18. Multi-symplectic Preissmann methods for generalized Zakharov-Kuznetsov equation

    International Nuclear Information System (INIS)

    Wang Junjie; Yang Kuande; Wang Liantang

    2012-01-01

    Generalized Zakharov-Kuznetsov equation, a typical nonlinear wave equation, was studied based on the multi-symplectic theory in Hamilton space. The multi-symplectic formulations of generalized Zakharov-Kuznetsov equation with several conservation laws are presented. The multi-symplectic Preissmann method is used to discretize the formulations. The numerical experiment is given, and the results verify the efficiency of the multi-symplectic scheme. (authors)

  19. Canonical and symplectic analysis for three dimensional gravity without dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Escalante, Alberto, E-mail: aescalan@ifuap.buap.mx [Instituto de Física, Benemérita Universidad Autónoma de Puebla, Apartado Postal J-48 72570, Puebla, Pue. (Mexico); Osmart Ochoa-Gutiérrez, H. [Facultad de Ciencias Físico Matemáticas, Benemérita Universidad Autónoma de Puebla, Apartado postal 1152, 72001 Puebla, Pue. (Mexico)

    2017-03-15

    In this paper a detailed Hamiltonian analysis of three-dimensional gravity without dynamics proposed by V. Hussain is performed. We report the complete structure of the constraints and the Dirac brackets are explicitly computed. In addition, the Faddeev–Jackiw symplectic approach is developed; we report the complete set of Faddeev–Jackiw constraints and the generalized brackets, then we show that the Dirac and the generalized Faddeev–Jackiw brackets coincide to each other. Finally, the similarities and advantages between Faddeev–Jackiw and Dirac’s formalism are briefly discussed. - Highlights: • We report the symplectic analysis for three dimensional gravity without dynamics. • We report the Faddeev–Jackiw constraints. • A pure Dirac’s analysis is performed. • The complete structure of Dirac’s constraints is reported. • We show that symplectic and Dirac’s brackets coincide to each other.

  20. Explicit high-order non-canonical symplectic particle-in-cell algorithms for Vlasov-Maxwell systems

    International Nuclear Information System (INIS)

    Xiao, Jianyuan; Liu, Jian; He, Yang; Zhang, Ruili; Qin, Hong; Sun, Yajuan

    2015-01-01

    Explicit high-order non-canonical symplectic particle-in-cell algorithms for classical particle-field systems governed by the Vlasov-Maxwell equations are developed. The algorithms conserve a discrete non-canonical symplectic structure derived from the Lagrangian of the particle-field system, which is naturally discrete in particles. The electromagnetic field is spatially discretized using the method of discrete exterior calculus with high-order interpolating differential forms for a cubic grid. The resulting time-domain Lagrangian assumes a non-canonical symplectic structure. It is also gauge invariant and conserves charge. The system is then solved using a structure-preserving splitting method discovered by He et al. [preprint http://arxiv.org/abs/arXiv:1505.06076 (2015)], which produces five exactly soluble sub-systems, and high-order structure-preserving algorithms follow by combinations. The explicit, high-order, and conservative nature of the algorithms is especially suitable for long-term simulations of particle-field systems with extremely large number of degrees of freedom on massively parallel supercomputers. The algorithms have been tested and verified by the two physics problems, i.e., the nonlinear Landau damping and the electron Bernstein wave

  1. Explicit high-order non-canonical symplectic particle-in-cell algorithms for Vlasov-Maxwell systems

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Jianyuan [School of Nuclear Science and Technology and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China; Key Laboratory of Geospace Environment, CAS, Hefei, Anhui 230026, China; Qin, Hong [School of Nuclear Science and Technology and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China; Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543, USA; Liu, Jian [School of Nuclear Science and Technology and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China; Key Laboratory of Geospace Environment, CAS, Hefei, Anhui 230026, China; He, Yang [School of Nuclear Science and Technology and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China; Key Laboratory of Geospace Environment, CAS, Hefei, Anhui 230026, China; Zhang, Ruili [School of Nuclear Science and Technology and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, China; Key Laboratory of Geospace Environment, CAS, Hefei, Anhui 230026, China; Sun, Yajuan [LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, P.O. Box 2719, Beijing 100190, China

    2015-11-01

    Explicit high-order non-canonical symplectic particle-in-cell algorithms for classical particle-field systems governed by the Vlasov-Maxwell equations are developed. The algorithms conserve a discrete non-canonical symplectic structure derived from the Lagrangian of the particle-field system, which is naturally discrete in particles. The electromagnetic field is spatially discretized using the method of discrete exterior calculus with high-order interpolating differential forms for a cubic grid. The resulting time-domain Lagrangian assumes a non-canonical symplectic structure. It is also gauge invariant and conserves charge. The system is then solved using a structure-preserving splitting method discovered by He et al. [preprint arXiv: 1505.06076 (2015)], which produces five exactly soluble sub-systems, and high-order structure-preserving algorithms follow by combinations. The explicit, high-order, and conservative nature of the algorithms is especially suitable for long-term simulations of particle-field systems with extremely large number of degrees of freedom on massively parallel supercomputers. The algorithms have been tested and verified by the two physics problems, i.e., the nonlinear Landau damping and the electron Bernstein wave. (C) 2015 AIP Publishing LLC.

  2. Explicit K-symplectic algorithms for charged particle dynamics

    International Nuclear Information System (INIS)

    He, Yang; Zhou, Zhaoqi; Sun, Yajuan; Liu, Jian; Qin, Hong

    2017-01-01

    We study the Lorentz force equation of charged particle dynamics by considering its K-symplectic structure. As the Hamiltonian of the system can be decomposed as four parts, we are able to construct the numerical methods that preserve the K-symplectic structure based on Hamiltonian splitting technique. The newly derived numerical methods are explicit, and are shown in numerical experiments to be stable over long-term simulation. The error convergency as well as the long term energy conservation of the numerical solutions is also analyzed by means of the Darboux transformation.

  3. Proton spin tracking with symplectic integration of orbit motion

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Dutheil, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ranjbar, V. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    Symplectic integration had been adopted for orbital motion tracking in code SimTrack. SimTrack has been extensively used for dynamic aperture calculation with beam-beam interaction for the Relativistic Heavy Ion Collider (RHIC). Recently proton spin tracking has been implemented on top of symplectic orbital motion in this code. In this article, we will explain the implementation of spin motion based on Thomas-BMT equation, and the benchmarking with other spin tracking codes currently used for RHIC. Examples to calculate spin closed orbit and spin tunes are presented too.

  4. Explicit K-symplectic algorithms for charged particle dynamics

    Energy Technology Data Exchange (ETDEWEB)

    He, Yang [School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083 (China); Zhou, Zhaoqi [LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, P.O. Box 2719, Beijing 100190 (China); Sun, Yajuan, E-mail: sunyj@lsec.cc.ac.cn [LSEC, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, P.O. Box 2719, Beijing 100190 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Liu, Jian [Department of Modern Physics and School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026 (China); Key Laboratory of Geospace Environment, CAS, Hefei, Anhui 230026 (China); Qin, Hong [Department of Modern Physics and School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026 (China); Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States)

    2017-02-12

    We study the Lorentz force equation of charged particle dynamics by considering its K-symplectic structure. As the Hamiltonian of the system can be decomposed as four parts, we are able to construct the numerical methods that preserve the K-symplectic structure based on Hamiltonian splitting technique. The newly derived numerical methods are explicit, and are shown in numerical experiments to be stable over long-term simulation. The error convergency as well as the long term energy conservation of the numerical solutions is also analyzed by means of the Darboux transformation.

  5. Rotation number of integrable symplectic mappings of the plane

    Energy Technology Data Exchange (ETDEWEB)

    Zolkin, Timofey [Fermilab; Nagaitsev, Sergei [Fermilab; Danilov, Viatcheslav [Oak Ridge

    2017-04-11

    Symplectic mappings are discrete-time analogs of Hamiltonian systems. They appear in many areas of physics, including, for example, accelerators, plasma, and fluids. Integrable mappings, a subclass of symplectic mappings, are equivalent to a Twist map, with a rotation number, constant along the phase trajectory. In this letter, we propose a succinct expression to determine the rotation number and present two examples. Similar to the period of the bounded motion in Hamiltonian systems, the rotation number is the most fundamental property of integrable maps and it provides a way to analyze the phase-space dynamics.

  6. Major shell centroids in the symplectic collective model

    International Nuclear Information System (INIS)

    Draayer, J.P.; Rosensteel, G.; Tulane Univ., New Orleans, LA

    1983-01-01

    Analytic expressions are given for the major shell centroids of the collective potential V(#betta#, #betta#) and the shape observable #betta# 2 in the Sp(3,R) symplectic model. The tools of statistical spectroscopy are shown to be useful, firstly, in translating a requirement that the underlying shell structure be preserved into constraints on the parameters of the collective potential and, secondly, in giving a reasonable estimate for a truncation of the infinite dimensional symplectic model space from experimental B(E2) transition strengths. Results based on the centroid information are shown to compare favorably with results from exact calculations in the case of 20 Ne. (orig.)

  7. Conjunction of anti-parallel and component reconnection at the dayside MP: Cluster and Double Star coordinated observation on 6 April 2004

    Science.gov (United States)

    Wang, J.; Pu, Z. Y.; Fu, S. Y.; Wang, X. G.; Xiao, C. J.; Dunlop, M. W.; Wei, Y.; Bogdanova, Y. V.; Zong, Q. G.; Xie, L.

    2011-05-01

    Previous theoretical and simulation studies have suggested that the anti-parallel and component reconnection can occur simultaneously on the dayside magnetopause. Certain observations have also been reported to support global conjunct pattern of magnetic reconnection. Here, we show direct evidence for the conjunction of anti-parallel and component MR using coordinated observations of Double Star TC-1 and Cluster under the same IMF condition on 6 April, 2004. The global MR X-line configuration constructed is in good agreement with the “S-shape” model.

  8. Effect of Probiotic Curd on Salivary pH and Streptococcus mutans: A Double Blind Parallel Randomized Controlled Trial.

    Science.gov (United States)

    Srivastava, Shivangi; Saha, Sabyasachi; Kumari, Minti; Mohd, Shafaat

    2016-02-01

    Dairy products like curd seem to be the most natural way to ingest probiotics which can reduce Streptococcus mutans level and also increase salivary pH thereby reducing the dental caries risk. To estimate the role of probiotic curd on salivary pH and Streptococcus mutans count, over a period of 7 days. This double blind parallel randomized clinical trial was conducted at the institution with 60 caries free volunteers belonging to the age group of 20-25 years who were randomly allocated into two groups. Test Group consisted of 30 subjects who consumed 100ml of probiotic curd daily for seven days while an equal numbered Control Group were given 100ml of regular curd for seven days. Saliva samples were assessed at baseline, after ½ hour 1 hour and 7 days of intervention period using pH meter and Mitis Salivarius Bacitracin agar to estimate salivary pH and S. mutans count. Data was statistically analysed using Paired and Unpaired t-test. The study revealed a reduction in salivary pH after ½ hour and 1 hour in both the groups. However after 7 days, normal curd showed a statistically significant (psalivary pH while probiotic curd showed a statistically significant (psalivary pH. Similarly with regard to S. mutans colony counts probiotic curd showed statistically significant reduction (psalivary pH elevation and reduction of salivary S. mutans counts and thus can be exploited for the prevention of enamel demineralization as a long-term remedy keeping in mind its cost effectiveness.

  9. Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study.

    Science.gov (United States)

    Zheng, Jinping; Yang, Jinghua; Zhou, Xiangdong; Zhao, Li; Hui, Fuxin; Wang, Haoyan; Bai, Chunxue; Chen, Ping; Li, Huiping; Kang, Jian; Brose, Manja; Richard, Frank; Goehring, Udo-Michael; Zhong, Nanshan

    2014-01-01

    Roflumilast is the only oral phosphodiesterase 4 inhibitor indicated for use in the treatment of COPD. Previous studies of roflumilast have predominantly involved European and North American populations. A large study was necessary to determine the efficacy and safety of roflumilast in a predominantly ethnic Chinese population. In a placebo-controlled, double-blind, parallel-group, multicenter, phase 3 study, patients of Chinese, Malay, and Indian ethnicity (N = 626) with severe to very severe COPD were randomized 1:1 to receive either roflumilast 500 μg once daily or placebo for 24 weeks. The primary end point was change in prebronchodilator FEV1 from baseline to study end. Three hundred thirteen patients were assigned to each treatment. Roflumilast provided a sustained increase over placebo in mean prebronchodilator FEV1 (0.071 L; 95% CI, 0.046, 0.095 L; P < .0001). Similar improvements were observed in the secondary end points of postbronchodilator FEV1 (0.068 L; 95% CI 0.044, 0.092 L; P < .0001) and prebronchodilator and postbronchodilator FVC (0.109 L; 95% CI, 0.061, 0.157 L; P < .0001 and 0.101 L; 95% CI, 0.055, 0.146 L; P < .0001, respectively). The adverse event profile was consistent with previous roflumilast studies. The most frequently reported treatment-related adverse event was diarrhea (6.0% and 1.0% of patients in the roflumilast and placebo groups, respectively). Roflumilast plays an important role in lung function improvement and is well tolerated in an Asian population. It provides an optimal treatment choice for patients with severe to very severe COPD.

  10. The efficacy of Femal in women with premenstrual syndrome: a randomised, double-blind, parallel-group, placebo-controlled, multicentre study

    DEFF Research Database (Denmark)

    Gerhardsen, G.; Hansen, A.V.; Killi, M.

    2008-01-01

    Introduction: A double-blind, placebo-controlled, randomised, parallel-group, multicentre study was conducted to evaluate the effect of a pollen-based herbal medicinal product, Femal (R) (Sea-Band Ltd, Leicestershire, UK), on premenstrual sleep disturbances (PSD) in women with premenstrual syndrome...... as the main symptom cluster makes this herbal medicinal product a promising addition to the therapeutic arsenal for women with PMS Udgivelsesdato: 2008/6...

  11. Symplectic and Hamiltonian structures of nonlinear evolution equations

    International Nuclear Information System (INIS)

    Dorfman, I.Y.

    1993-01-01

    A Hamiltonian structure on a finite-dimensional manifold can be introduced either by endowing it with a (pre)symplectic structure, or by describing the Poisson bracket with the help of a tensor with two upper indices named the Poisson structure. Under the assumption of nondegeneracy, the Poisson structure is nothing else than the inverse of the symplectic structure. Also in the degenerate case the distinction between the two approaches is almost insignificant, because both presymplectic and Poisson structures split into symplectic structures on leaves of appropriately chosen foliations. Hamiltonian structures that arise in the theory of evolution equations demonstrate something new in this respect: trying to operate in local terms, one is induced to develop both approaches independently. Hamiltonian operators, being the infinite-dimensional counterparts of Poisson structures, were the first to become the subject of investigations. A considerable period of time passed before the papers initiated research in the theory of symplectic operators, being the counterparts of presymplectic structures. In what follows, we focus on the main achievements in this field

  12. Symplectic dynamics of the nuclear mean-field

    International Nuclear Information System (INIS)

    Grigorescu, Marius

    1996-01-01

    Collective and microscopic pictures of the nuclear dynamics are related in the frame of time-dependent variational principle on symplectic trial manifolds. For symmetry braking systems such manifolds are constructed by cranking, and applied to study the nuclear isovector collective excitations. (author)

  13. A survey of open problems in symplectic integration

    Energy Technology Data Exchange (ETDEWEB)

    McLachlan, R.I. [Univ. of Colorado, Boulder, CO (United States); Scovel, C. [Los Alamos National Lab., NM (United States)

    1993-10-15

    In the past few years there has been a substantial amount of research on symplectic integration. The subject is only part of a program concerned with numerically preserving a system`s inherent geometrical structures. Volume preservation, reversibility, local conservation laws for elliptic equations, and systems with integral invariants are but a few examples of such invariant structures. In many cases one requires a numerical method to stay in the smallest possible appropriate group of phase space maps. It is not the authors` opinion that symplecticity, for example, automatically makes a numerical method superior to all others, but it is their opinion that it should be taken seriously and that a conscious, informed decision be made in that regard. The authors present here a survey of open problems in symplectic integration, including other problems from the larger program. This is not intended as a review of symplectic integration and is naturally derived from the authors` own research interests. At present, this survey is incomplete, but the authors hope the help of the colleagues to be able to include in the proceedings of this conference a more comprehensive survey. Many of the problems mentioned here call for numerical experimentation, some for application of suggested but untested methods, some for new methods, and some for theorems, Some envisage large research programs.

  14. A Note on Symplectic, Multisymplectic Scheme in Finite Element Method

    Institute of Scientific and Technical Information of China (English)

    GUO Han-Ying; JI Xiao-Mei; LI Yu-Qi; WU Ke

    2001-01-01

    We find that with uniform mesh, the numerical schemes derived from finite element method can keep a preserved symplectic structure in one-dimensional case and a preserved multisymplectic structure in two-dimensional case respectively. These results are in fact the intrinsic reason why the numerical experiments show that such finite element algorithms are accurate in practice.``

  15. Relative symplectic caps, 4-genus and fibered knots

    Indian Academy of Sciences (India)

    convex boundary embeds in a closed symplectic 4-manifold. ... We shall apply Theorem 1.2 in particular to study the 4-genus of a link in S3 by proving ...... [13] Honda Ko, Factoring nonrotative T 2×I layers, Erratum: On the classification of tight.

  16. Local symplectic operators and structures related to them

    International Nuclear Information System (INIS)

    Dorfman, I.Y.; Mokhov, O.I.

    1991-01-01

    Matrices with entries being differential operators, that endow the phase space of an evolution system with a (pre)symplectic structure are considered. Special types of such structures are explicitly described. Links with integrability, geometry of loop spaces, and Baecklund transformations are traces

  17. Deformations of coisotropic submanifolds in locally conformal symplectic manifolds

    Czech Academy of Sciences Publication Activity Database

    Le, Hong-Van; Oh, Y.-G.

    2016-01-01

    Roč. 20, č. 3 (2016), s. 553-596 ISSN 1093-6106 Institutional support: RVO:67985840 Keywords : locally conformal symplectic manifold * coisotropic submanifold * b-twisted differential * bulk deformation Subject RIV: BA - General Mathematics Impact factor: 0.895, year: 2016 http://intlpress.com/site/pub/pages/journals/items/ajm/content/vols/0020/0003/a007/index.html

  18. Deformations of Lagrangian subvarieties of holomorphic symplectic manifolds

    OpenAIRE

    Lehn, Christian

    2011-01-01

    We generalize Voisin's theorem on deformations of pairs of a symplectic manifold and a Lagrangian submanifold to the case of Lagrangian normal crossing subvarieties. Partial results are obtained for arbitrary Lagrangian subvarieties. We apply our results to the study of singular fibers of Lagrangian fibrations.

  19. Study protocol: Brief intervention for medication overuse headache - A double-blinded cluster randomised parallel controlled trial in primary care

    Directory of Open Access Journals (Sweden)

    Kristoffersen Espen

    2012-08-01

    Full Text Available Abstract Background Chronic headache (headache ≥ 15 days/month for at least 3 months affects 2–5% of the general population. Medication overuse contributes to the problem. Medication-overuse headache (MOH can be identified by using the Severity of Dependence Scale (SDS. A “brief intervention” scheme (BI has previously been used for detoxification from drug and alcohol overuse in other settings. Short, unstructured, individualised simple information may also be enough to detoxify a large portion of those with MOH. We have adapted the structured (BI scheme to be used for MOH in primary care. Methods/Design A double-blinded cluster randomised parallel controlled trial (RCT of BI vs. business as usual. Intervention will be performed in primary care by GPs trained in BI. Patients with MOH will be identified through a simple screening questionnaire sent to patients on the GPs lists. The BI method involves an approach for identifying patients with high likelihood of MOH using simple questions about headache frequency and the SDS score. Feedback is given to the individual patient on his/her score and consequences this might have regarding the individual risk of medication overuse contributing to their headache. Finally, advice is given regarding measures to be taken, how the patient should proceed and the possible gains for the patient. The participating patients complete a headache diary and receive a clinical interview and neurological examination by a GP experienced in headache diagnostics three months after the intervention. Primary outcomes are number of headache days and number of medication days per month at 3 months. Secondary outcomes include proportions with 25 and 50% improvement at 3 months and maintenance of improvement and quality of life after 12 months. Discussion There is a need for evidence-based and cost-effective strategies for treatment of MOH but so far no consensus has been reached regarding an optimal medication

  20. Application of symplectic integrator to numerical fluid analysis

    International Nuclear Information System (INIS)

    Tanaka, Nobuatsu

    2000-01-01

    This paper focuses on application of the symplectic integrator to numerical fluid analysis. For the purpose, we introduce Hamiltonian particle dynamics to simulate fluid behavior. The method is based on both the Hamiltonian formulation of a system and the particle methods, and is therefore called Hamiltonian Particle Dynamics (HPD). In this paper, an example of HPD applications, namely the behavior of incompressible inviscid fluid, is solved. In order to improve accuracy of HPD with respect to space, CIVA, which is a highly accurate interpolation method, is combined, but the combined method is subject to problems in that the invariants of the system are not conserved in a long-time computation. For solving the problems, symplectic time integrators are introduced and the effectiveness is confirmed by numerical analyses. (author)

  1. Period mappings with applications to symplectic complex spaces

    CERN Document Server

    Kirschner, Tim

    2015-01-01

    Extending Griffiths’ classical theory of period mappings for compact Kähler manifolds, this book develops and applies a theory of period mappings of “Hodge-de Rham type” for families of open complex manifolds. The text consists of three parts. The first part develops the theory. The second part investigates the degeneration behavior of the relative Frölicher spectral sequence associated to a submersive morphism of complex manifolds. The third part applies the preceding material to the study of irreducible symplectic complex spaces. The latter notion generalizes the idea of an irreducible symplectic manifold, dubbed an irreducible hyperkähler manifold in differential geometry, to possibly singular spaces. The three parts of the work are of independent interest, but intertwine nicely.

  2. Noncommutativity and Duality through the Symplectic Embedding Formalism

    Directory of Open Access Journals (Sweden)

    Everton M.C. Abreu

    2010-07-01

    Full Text Available This work is devoted to review the gauge embedding of either commutative and noncommutative (NC theories using the symplectic formalism framework. To sum up the main features of the method, during the process of embedding, the infinitesimal gauge generators of the gauge embedded theory are easily and directly chosen. Among other advantages, this enables a greater control over the final Lagrangian and brings some light on the so-called ''arbitrariness problem''. This alternative embedding formalism also presents a way to obtain a set of dynamically dual equivalent embedded Lagrangian densities which is obtained after a finite number of steps in the iterative symplectic process, oppositely to the result proposed using the BFFT formalism. On the other hand, we will see precisely that the symplectic embedding formalism can be seen as an alternative and an efficient procedure to the standard introduction of the Moyal product in order to produce in a natural way a NC theory. In order to construct a pedagogical explanation of the method to the nonspecialist we exemplify the formalism showing that the massive NC U(1 theory is embedded in a gauge theory using this alternative systematic path based on the symplectic framework. Further, as other applications of the method, we describe exactly how to obtain a Lagrangian description for the NC version of some systems reproducing well known theories. Naming some of them, we use the procedure in the Proca model, the irrotational fluid model and the noncommutative self-dual model in order to obtain dual equivalent actions for these theories. To illustrate the process of noncommutativity introduction we use the chiral oscillator and the nondegenerate mechanics.

  3. Hydrodynamic Covariant Symplectic Structure from Bilinear Hamiltonian Functions

    Directory of Open Access Journals (Sweden)

    Capozziello S.

    2005-07-01

    Full Text Available Starting from generic bilinear Hamiltonians, constructed by covariant vector, bivector or tensor fields, it is possible to derive a general symplectic structure which leads to holonomic and anholonomic formulations of Hamilton equations of motion directly related to a hydrodynamic picture. This feature is gauge free and it seems a deep link common to all interactions, electromagnetism and gravity included. This scheme could lead toward a full canonical quantization.

  4. Asymptotic freedom and the symplectic and G2 groups

    International Nuclear Information System (INIS)

    Chaichian, M; Kolmakov, Yu. N.; Nelipa, N. F.

    1978-01-01

    It is shown that the symplectic Sp(4), Sp(6) and the exceptional G 2 gauge field theories with complete Spontaneous symmetry breaking through the Higgs mechanism are not asymptotically free. This, together with earlier results for other groups, hints at the existence of a general theorem according to which it would no longer be possible for asymptotic freedom to coexist with the absence of infrared divergences. (author)

  5. Symplectic tomography of nonclassical states of trapped ion

    International Nuclear Information System (INIS)

    Man'ko, O.

    1996-03-01

    The marginal distribution for two types of nonclassical states of trapped ion - for squeezed and correlated states and for squeezed even and odd coherent states (squeezed Schroedinger cat states) is studied. The obtained marginal distribution for the two types of states is shown to satisfy classical dynamical equation equivalent to standard quantum evolution equation for density matrix (wave function) derived in symplectic tomography scheme. (author). 20 refs

  6. Symplectic invariants of some families of Lagrangian T3-fibrations

    International Nuclear Information System (INIS)

    Castano Bernard, R.

    2003-12-01

    We construct families of Lagrangian 3-torus fibrations resembling the topology of some of the singularities in Topological Mirror Symmetry. We perform a detailed analysis of the affine structure on the base of these fibrations near their discriminant loci. This permits us to classify the aforementioned families up to fibre preserving symplectomorphism. The kind of degenerations we investigate give rise to a large number of symplectic invariants. (author)

  7. Gauge properties of the guiding center variational symplectic integrator

    International Nuclear Information System (INIS)

    Squire, J.; Tang, W. M.; Qin, H.

    2012-01-01

    Variational symplectic algorithms have recently been developed for carrying out long-time simulation of charged particles in magnetic fields [H. Qin and X. Guan, Phys. Rev. Lett. 100, 035006 (2008); H. Qin, X. Guan, and W. Tang, Phys. Plasmas (2009); J. Li, H. Qin, Z. Pu, L. Xie, and S. Fu, Phys. Plasmas 18, 052902 (2011)]. As a direct consequence of their derivation from a discrete variational principle, these algorithms have very good long-time energy conservation, as well as exactly preserving discrete momenta. We present stability results for these algorithms, focusing on understanding how explicit variational integrators can be designed for this type of system. It is found that for explicit algorithms, an instability arises because the discrete symplectic structure does not become the continuous structure in the t→0 limit. We examine how a generalized gauge transformation can be used to put the Lagrangian in the “antisymmetric discretization gauge,” in which the discrete symplectic structure has the correct form, thus eliminating the numerical instability. Finally, it is noted that the variational guiding center algorithms are not electromagnetically gauge invariant. By designing a model discrete Lagrangian, we show that the algorithms are approximately gauge invariant as long as A and φ are relatively smooth. A gauge invariant discrete Lagrangian is very important in a variational particle-in-cell algorithm where it ensures current continuity and preservation of Gauss’s law [J. Squire, H. Qin, and W. Tang (to be published)].

  8. Global symplectic structure-preserving integrators for spinning compact binaries

    Science.gov (United States)

    Zhong, Shuang-Ying; Wu, Xin; Liu, San-Qiu; Deng, Xin-Fa

    2010-12-01

    This paper deals mainly with the application of the second-order symplectic implicit midpoint rule and its symmetric compositions to a post-Newtonian Hamiltonian formulation with canonical spin variables in relativistic compact binaries. The midpoint rule, as a basic algorithm, is directly used to integrate the completely canonical Hamiltonian system. On the other hand, there are symmetric composite methods based on a splitting of the Hamiltonian into two parts: the Newtonian part associated with a Kepler motion, and a perturbation part involving the orbital post-Newtonian and spin contributions, where the Kepler flow has an analytic solution and the perturbation can be calculated by the midpoint rule. An example is the second-order mixed leapfrog symplectic integrator with one stage integration of the perturbation flow and two semistage computations of the Kepler flow at every integration step. Also, higher-order composite methods such as the Forest-Ruth fourth-order symplectic integrator and its optimized algorithm are applicable. Various numerical tests including simulations of chaotic orbits show that the mixed leapfrog integrator is always superior to the midpoint rule in energy accuracy, while both of them are almost equivalent in computational efficiency. Particularly, the optimized fourth-order algorithm compared with the mixed leapfrog scheme provides good precision and needs no expensive additional computational time. As a result, it is worth performing a more detailed and careful examination of the dynamical structure of chaos and order in the parameter windows and phase space of the binary system.

  9. Symmetric integrable-polynomial factorization for symplectic one-turn-map tracking

    International Nuclear Information System (INIS)

    Shi, Jicong

    1993-01-01

    It was found that any homogeneous polynomial can be written as a sum of integrable polynomials of the same degree which Lie transformations can be evaluated exactly. By utilizing symplectic integrators, an integrable-polynomial factorization is developed to convert a symplectic map in the form of Dragt-Finn factorization into a product of Lie transformations associated with integrable polynomials. A small number of factorization bases of integrable polynomials enable one to use high order symplectic integrators so that the high-order spurious terms can be greatly suppressed. A symplectic map can thus be evaluated with desired accuracy

  10. Symplectic Synchronization of Lorenz-Stenflo System with Uncertain Chaotic Parameters via Adaptive Control

    Directory of Open Access Journals (Sweden)

    Cheng-Hsiung Yang

    2013-01-01

    Full Text Available A new symplectic chaos synchronization of chaotic systems with uncertain chaotic parameters is studied. The traditional chaos synchronizations are special cases of the symplectic chaos synchronization. A sufficient condition is given for the asymptotical stability of the null solution of error dynamics and a parameter difference. The symplectic chaos synchronization with uncertain chaotic parameters may be applied to the design of secure communication systems. Finally, numerical results are studied for symplectic chaos synchronized from two identical Lorenz-Stenflo systems in three different cases.

  11. Thioflavin T binds dimeric parallel-stranded GA-containing non-G-quadruplex DNAs: a general approach to lighting up double-stranded scaffolds.

    Science.gov (United States)

    Liu, Shuangna; Peng, Pai; Wang, Huihui; Shi, Lili; Li, Tao

    2017-12-01

    A molecular rotor thioflavin T (ThT) is usually used as a fluorescent ligand specific for G-quadruplexes. Here, we demonstrate that ThT can tightly bind non-G-quadruplex DNAs with several GA motifs and dimerize them in a parallel double-stranded mode, accompanied by over 100-fold enhancement in the fluorescence emission of ThT. The introduction of reverse Watson-Crick T-A base pairs into these dimeric parallel-stranded DNA systems remarkably favors the binding of ThT into the pocket between G•G and A•A base pairs, where ThT is encapsulated thereby restricting its two rotary aromatic rings in the excited state. A similar mechanism is also demonstrated in antiparallel DNA duplexes where several motifs of two consecutive G•G wobble base pairs are incorporated and serve as the active pockets for ThT binding. The insight into the interactions of ThT with non-G-quadruplex DNAs allows us to introduce a new concept for constructing DNA-based sensors and devices. As proof-of-concept experiments, we design a DNA triplex containing GA motifs in its Hoogsteen hydrogen-bonded two parallel strands as a pH-driven nanoswitch and two GA-containing parallel duplexes as novel metal sensing platforms where C-C and T-T mismatches are included. This work may find further applications in biological systems (e.g. disease gene detection) where parallel duplex or triplex stretches are involved. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  12. Tramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trial

    Science.gov (United States)

    Rawal, Narinder; Macquaire, Valery; Catalá, Elena; Berti, Marco; Costa, Rui; Wietlisbach, Markus

    2011-01-01

    This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after surgery, and every 6 hours after discharge until midnight of the first postoperative day. Analgesic efficacy was assessed by patients (n = 128 in each group, full analysis set) and recorded in a diary on the evening of surgery day and of the first postoperative day. They also documented the occurrence of adverse events. By the end of the first postoperative day, the proportion of treatment responders based on treatment satisfaction (primary efficacy variable) was comparable between the groups (78.1% combination, 71.9% tramadol; P = 0.24) and mean pain intensity (rated on a numerical scale from 0 = no pain to 10 = worst imaginable pain) had been reduced to 1.7 ± 2.0 for both groups. Under both treatments, twice as many patients experienced no pain (score = 0) on the first postoperative day compared to the day of surgery (35.9% vs 16.4% for tramadol/paracetamol and 36.7% vs 18% for tramadol treatment). Rescue medication leading to withdrawal (diclofenac 50 mg) was required by 17.2% patients with tramadol/paracetamol and 13.3% with tramadol. Adverse events (mainly nausea, dizziness, somnolence, vomiting, and increased sweating) occurred less frequently in patients under combination treatment (P = 0.004). Tramadol/paracetamol combination tablets provided comparable analgesic efficacy with a better safety profile to tramadol capsules in patients experiencing postoperative pain following ambulatory hand surgery. PMID:21559356

  13. Bianchi type A hyper-symplectic and hyper-Kaehler metrics in 4D

    International Nuclear Information System (INIS)

    De Andrés, L C; Fernández, M; Ivanov, S; Santisteban, J A; Ugarte, L; Vassilev, D

    2012-01-01

    We present a simple explicit construction of hyper-Kaehler and hyper-symplectic (also known as neutral hyper-Kaehler or hyper-para-Kaehler) metrics in 4D using the Bianchi type groups of class A. The construction underlies a correspondence between hyper-Kaehler and hyper-symplectic structures of dimension 4. (paper)

  14. Bianchi type A hyper-symplectic and hyper-K\\"ahler metrics in 4D

    OpenAIRE

    de Andrés, Luis C.; Fernández, Marisa; Ivanov, Stefan; Santisteban, José A.; Ugarte, Luis; Vassilev, Dimiter

    2011-01-01

    We present a simple explicit construction of hyper-Kaehler and hyper-symplectic (also known as neutral hyper-Kaehler or hyper-parakaehler) metrics in 4D using the Bianchi type groups of class A. The construction underlies a correspondence between hyper-Kaehler and hyper-symplectic structures in dimension four.

  15. A Family of Trigonometrically-fitted Partitioned Runge-Kutta Symplectic Methods

    International Nuclear Information System (INIS)

    Monovasilis, Th.; Kalogiratou, Z.; Simos, T. E.

    2007-01-01

    We are presenting a family of trigonometrically fitted partitioned Runge-Kutta symplectic methods of fourth order with six stages. The solution of the one dimensional time independent Schroedinger equation is considered by trigonometrically fitted symplectic integrators. The Schroedinger equation is first transformed into a Hamiltonian canonical equation. Numerical results are obtained for the one-dimensional harmonic oscillator and the exponential potential

  16. Examples of integrable and non-integrable systems on singular symplectic manifolds

    Science.gov (United States)

    Delshams, Amadeu; Kiesenhofer, Anna; Miranda, Eva

    2017-05-01

    We present a collection of examples borrowed from celestial mechanics and projective dynamics. In these examples symplectic structures with singularities arise naturally from regularization transformations, Appell's transformation or classical changes like McGehee coordinates, which end up blowing up the symplectic structure or lowering its rank at certain points. The resulting geometrical structures that model these examples are no longer symplectic but symplectic with singularities which are mainly of two types: bm-symplectic and m-folded symplectic structures. These examples comprise the three body problem as non-integrable exponent and some integrable reincarnations such as the two fixed-center problem. Given that the geometrical and dynamical properties of bm-symplectic manifolds and folded symplectic manifolds are well-understood [10-12,9,15,13,14,24,20,22,25,28], we envisage that this new point of view in this collection of examples can shed some light on classical long-standing problems concerning the study of dynamical properties of these systems seen from the Poisson viewpoint.

  17. A new multi-symplectic scheme for the generalized Kadomtsev-Petviashvili equation

    Science.gov (United States)

    Li, Haochen; Sun, Jianqiang

    2012-09-01

    We propose a new scheme for the generalized Kadomtsev-Petviashvili (KP) equation. The multi-symplectic conservation property of the new scheme is proved. Back error analysis shows that the new multi-symplectic scheme has second order accuracy in space and time. Numerical application on studying the KPI equation and the KPII equation are presented in detail.

  18. Precise iteration formulae of the Maslov-type index theory for symplectic paths

    International Nuclear Information System (INIS)

    Yiming Long

    1998-10-01

    In this paper, using homotopy components of symplectic matrices, and basic properties of the Maslov-type index theory, we establish precise iteration formulae of the Maslov-type index theory for any path in the symplectic group starting from the identity. (author)

  19. Tramadol/paracetamol combination tablet for postoperative pain following ambulatory hand surgery: a double-blind, double-dummy, randomized, parallel-group trial

    Directory of Open Access Journals (Sweden)

    Rawal N

    2011-04-01

    Full Text Available Narinder Rawal1, Valery Macquaire2, Elena Catalá3, Marco Berti4, Rui Costa5, Markus Wietlisbach61Department of Anesthesiology and Intensive Care, Örebro University Hospital, Örebro, Sweden; 2Clinique du Parc Leopold, Brussels, Belgium; 3Pain Clinic, Department Anesthesiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; 4Department of Anesthesiology and Reanimation, Parma Hospital, Parma, Italy; 5Garcia de Orta Hospital, Almada, Portugal; 6Department of Anesthesiology, Sursee Hospital, Sursee, SwitzerlandAbstract: This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after surgery, and every 6 hours after discharge until midnight of the first postoperative day. Analgesic efficacy was assessed by patients (n = 128 in each group, full analysis set and recorded in a diary on the evening of surgery day and of the first postoperative day. They also documented the occurrence of adverse events. By the end of the first postoperative day, the proportion of treatment responders based on treatment satisfaction (primary efficacy variable was comparable between the groups (78.1% combination, 71.9% tramadol; P = 0.24 and mean pain intensity (rated on a numerical scale from 0 = no pain to 10 = worst imaginable pain had been reduced to 1.7 ± 2.0 for both groups. Under both treatments, twice as many patients experienced no pain (score = 0 on the first postoperative day compared to the day of surgery (35.9% vs 16.4% for tramadol/paracetamol and 36.7% vs 18% for tramadol treatment. Rescue medication leading to withdrawal (diclofenac 50 mg was required by 17.2% patients with tramadol/paracetamol and 13.3% with tramadol. Adverse events (mainly nausea, dizziness

  20. SCA resistant Parallel Explicit Formula for Addition and Doubling of Divisors in the Jacobian of Hyperelliptic Curves of Genus 2

    DEFF Research Database (Denmark)

    Lange, Tanja; Mishra, Pradeep Kumar

    2005-01-01

    Hyperelliptic curve cryptosystems (HECC) can be implemented on a variety of computing devices, starting from smart cards to high end workstations. Side-channel attacks are one of the most potential threats against low genus HECC. Thus efficient algorithms resistant against side channel attacks...... cheap dummy operations to make all traces look identical. So far a detailed study of countermeasures against side-channel attacks exists only for differential attacks. There one assumes that the performance is made predictable by other means. But apart from the double-and-alway-add approach only...

  1. Symplectic manifolds, coadjoint orbits, and Mean Field Theory

    International Nuclear Information System (INIS)

    Rosensteel, G.

    1986-01-01

    Mean field theory is given a geometrical interpretation as a Hamiltonian dynamical system. The Hartree-Fock phase space is the Grassmann manifold, a symplectic submanifold of the projective space of the full many-fermion Hilbert space. The integral curves of the Hartree-Fock vector field are the time-dependent Hartree-Fock solutions, while the critical points of the energy function are the time-independent states. The mean field theory is generalized beyond determinants to coadjoint orbit spaces of the unitary group; the Grassmann variety is the minimal coadjoint orbit

  2. The endoscopic classification of representations orthogonal and symplectic groups

    CERN Document Server

    Arthur, James

    2013-01-01

    Within the Langlands program, endoscopy is a fundamental process for relating automorphic representations of one group with those of another. In this book, Arthur establishes an endoscopic classification of automorphic representations of orthogonal and symplectic groups G. The representations are shown to occur in families (known as global L-packets and A-packets), which are parametrized by certain self-dual automorphic representations of an associated general linear group GL(N). The central result is a simple and explicit formula for the multiplicity in the automorphic discrete spectrum of G

  3. Introduction to orthogonal, symplectic and unitary representations of finite groups

    CERN Document Server

    Riehm, Carl R

    2011-01-01

    Orthogonal, symplectic and unitary representations of finite groups lie at the crossroads of two more traditional subjects of mathematics-linear representations of finite groups, and the theory of quadratic, skew symmetric and Hermitian forms-and thus inherit some of the characteristics of both. This book is written as an introduction to the subject and not as an encyclopaedic reference text. The principal goal is an exposition of the known results on the equivalence theory, and related matters such as the Witt and Witt-Grothendieck groups, over the "classical" fields-algebraically closed, rea

  4. Differential and symplectic topology of knots and curves

    CERN Document Server

    Tabachnikov, S

    1999-01-01

    This book presents a collection of papers on two related topics: topology of knots and knot-like objects (such as curves on surfaces) and topology of Legendrian knots and links in 3-dimensional contact manifolds. Featured is the work of international experts in knot theory (""quantum"" knot invariants, knot invariants of finite type), in symplectic and contact topology, and in singularity theory. The interplay of diverse methods from these fields makes this volume unique in the study of Legendrian knots and knot-like objects such as wave fronts. A particularly enticing feature of the volume is

  5. Method to render second order beam optics programs symplectic

    International Nuclear Information System (INIS)

    Douglas, D.; Servranckx, R.V.

    1984-10-01

    We present evidence that second order matrix-based beam optics programs violate the symplectic condition. A simple method to avoid this difficulty, based on a generating function approach to evaluating transfer maps, is described. A simple example illustrating the non-symplectricity of second order matrix methods, and the effectiveness of our solution to the problem, is provided. We conclude that it is in fact possible to bring second order matrix optics methods to a canonical form. The procedure for doing so has been implemented in the program DIMAT, and could be implemented in programs such as TRANSPORT and TURTLE, making them useful in multiturn applications. 15 refs

  6. A Symplectic Beam-Beam Interaction with Energy Change

    International Nuclear Information System (INIS)

    Moshammer, Herbert

    2003-01-01

    The performance of many colliding storage rings is limited by the beam-beam interaction. A particle feels a nonlinear force produced by the encountering bunch at the collision. This beam-beam force acts mainly in the transverse directions so that the longitudinal effects have scarcely been studied, except for the cases of a collision with a crossing angle. Recently, however, high luminosity machines are being considered where the beams are focused extensively at the interaction point (IP) so that the beam sizes can vary significantly within the bunch length. Krishnagopal and Siemann have shown that they should not neglect the bunch length effect in this case. The transverse kick depends on the longitudinal position as well as on the transverse position. If they include this effect, however, from the action-reaction principle, they should expect, at the same time, an energy change which depends on the transverse coordinates. Such an effect is reasonably understood from the fact that the beam-beam force is partly due to the electric field, which can change the energy. The action-reaction principle comes from the symplecticity of the reaction: the electromagnetic influence on a particle is described by a Hamiltonian. The symplecticity is one of the most fundamental requirements when studying the beam dynamics. A nonsymplectic approximation can easily lead to unphysical results. In this paper, they propose a simple, approximately but symplectic mapping for the beam-beam interaction which includes the energy change as well as the bunch-length effect. In the next section, they propose the mapping in a Hamiltonian form, which directly assures its symplecticity. Then in section 3, they study the nature of the mapping by interpreting its consequences. The mapping itself is quite general and can be applied to any distribution function. They show in Section 4 how it appears when the distribution function is a Gaussian in transverse directions. The mapping is applied to the

  7. A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected].

    Science.gov (United States)

    Micallef, J; Soubrouillard, C; Guet, F; Le Guern, M E; Alquier, C; Bruguerolle, B; Blin, O

    2001-06-01

    This paper describes the psychomotor and mnesic effects of single oral doses of etifoxine (50 and 100 mg) and lorazepam (2 mg) in healthy subjects. Forty-eight healthy subjects were included in this randomized double blind, placebo controlled parallel group study [corrected]. The effects of drugs were assessed by using a battery of subjective and objective tests that explored mood and vigilance (Visual Analog Scale), attention (Barrage test), psychomotor performance (Choice Reaction Time) and memory (digit span, immediate and delayed free recall of a word list). Whereas vigilance, psychomotor performance and free recall were significantly impaired by lorazepam, neither dosage of etifoxine (50 and 100 mg) produced such effects. These results suggest that 50 and 100 mg single dose of etifoxine do not induce amnesia and sedation as compared to lorazepam.

  8. An Optimization-Based Reconfigurable Design for a 6-Bit 11-MHz Parallel Pipeline ADC with Double-Sampling S&H

    Directory of Open Access Journals (Sweden)

    Wilmar Carvajal

    2012-01-01

    Full Text Available This paper presents a 6 bit, 11 MS/s time-interleaved pipeline A/D converter design. The specification process, from block level to elementary circuits, is gradually covered to draw a design methodology. Both power consumption and mismatch between the parallel chain elements are intended to be reduced by using some techniques such as double and bottom-plate sampling, fully differential circuits, RSD digital correction, and geometric programming (GP optimization of the elementary analog circuits (OTAs and comparators design. Prelayout simulations of the complete ADC are presented to characterize the designed converter, which consumes 12 mW while sampling a 500 kHz input signal. Moreover, the block inside the ADC with the most stringent requirements in power, speed, and precision was sent to fabrication in a CMOS 0.35 μm AMS technology, and some postlayout results are shown.

  9. An hp symplectic pseudospectral method for nonlinear optimal control

    Science.gov (United States)

    Peng, Haijun; Wang, Xinwei; Li, Mingwu; Chen, Biaosong

    2017-01-01

    An adaptive symplectic pseudospectral method based on the dual variational principle is proposed and is successfully applied to solving nonlinear optimal control problems in this paper. The proposed method satisfies the first order necessary conditions of continuous optimal control problems, also the symplectic property of the original continuous Hamiltonian system is preserved. The original optimal control problem is transferred into a set of nonlinear equations which can be solved easily by Newton-Raphson iterations, and the Jacobian matrix is found to be sparse and symmetric. The proposed method, on one hand, exhibits exponent convergence rates when the number of collocation points are increasing with the fixed number of sub-intervals; on the other hand, exhibits linear convergence rates when the number of sub-intervals is increasing with the fixed number of collocation points. Furthermore, combining with the hp method based on the residual error of dynamic constraints, the proposed method can achieve given precisions in a few iterations. Five examples highlight the high precision and high computational efficiency of the proposed method.

  10. QCD gauge symmetries through Faddeev-Jackiw symplectic method

    International Nuclear Information System (INIS)

    Abreu, E.M.C.; Mendes, A.C.R.; Neves, C.; Oliveira, W.; Silva, R.C.N.

    2013-01-01

    Full text: The FJ method is an approach that is geometrically motivated. It is based on the symplectic structure of the phase space. The first-order characteristic allows to obtain the Hamiltonian equations of motion from a variational principle. Its geometric structure of the Hamiltonian phase-space will be carried out directly from the equations of motion via the inverse of the so-called symplectic two-form, if the inverse exists. Few years after its publication, the FJ formalism was extended and through the years it has been applied to different systems. Gauge invariance is one of the most well established concepts in theoretical physics and it is one of the main ingredients in Standard Model theory. However, we can ask if it could have an alternative origin connected to another theory or principle. With this motivation in mind we will show in this paper that gauge invariance could be considered an emergent concept having its origin in the algebraic formalism of a well known method that deals with constrained systems, namely, the Faddeev-Jackiw (FJ) technique. Of course the gauge invariance idea is older than FJ's, but the results obtained here will show that the connection between both will prove that SU(3) and SU(3) X SU(2) X U(1) gauge groups, which are fundamental to important theories like QCD and Standard Model, can be obtained through FJ formalism. (author)

  11. DNA with Parallel Strand Orientation: A Nanometer Distance Study with Spin Labels in the Watson-Crick and the Reverse Watson-Crick Double Helix.

    Science.gov (United States)

    Wunnicke, Dorith; Ding, Ping; Yang, Haozhe; Seela, Frank; Steinhoff, Heinz-Jürgen

    2015-10-29

    Parallel-stranded (ps) DNA characterized by its sugar-phosphate backbones pointing in the same direction represents an alternative pairing system to antiparallel-stranded (aps) DNA with the potential to inhibit transcription and translation. 25-mer oligonucleotides were selected containing only dA·dT base pairs to compare spin-labeled nucleobase distances over a range of 10 or 15 base pairs in ps DNA with those in aps DNA. By means of the copper(I)-catalyzed Huisgen-Meldal-Sharpless alkyne-azide cycloaddition, the spin label 4-azido-2,2,6,6-tetramethylpiperidine-1-oxyl was clicked to 7-ethynyl-7-deaza-2'-deoxyadenosine or 5-ethynyl-2'-deoxyuridine to yield 25-mer oligonucleotides incorporating two spin labels. The interspin distances between spin labeled residues were determined by pulse EPR spectroscopy. The results reveal that in ps DNA these distances are between 5 and 10% longer than in aps DNA when the labeled DNA segment is located near the center of the double helix. The interspin distance in ps DNA becomes shorter compared with aps DNA when one of the spin labels occupies a position near the end of the double helix.

  12. [Comparison of benazepril monotherapy to amlodipine plus benazepril in the treatment of patients with mild and moderate hypertension: a multicentre, randomized, double-blind, parallel-controlled study].

    Science.gov (United States)

    Fan, Chao-mei; Yan, Li-rong; Tao, Yong-kang; Wang, Li; Li, Yu-qing; Gao, Ming-ming; Wang, Yan-ni; Li, Cheng-xiang; Wang, Xiao-wan; Lu, Xiao-lei; Pang, Hui-min; Li, Yi-shi

    2011-01-01

    To evaluate the efficacy and tolerability of the fixed combination of amlodipine 5 mg/benazepril 10 mg once-daily therapy, compared with benazepril, 10 mg, monotherapy in patients with mild and moderate hypertension, and to evaluate the 24 h antihypertensive efficacy and the duration of action by ambulatory blood pressure monitoring. In a multicenter, randomized, double-blind, parallel controlled trial, 356 cases of hypertensive patients after 2 weeks wash-out, and then given 4 weeks of benazepril 10 mg monotherapy, 220 patients with mean seated diastolic blood pressure (SeDBP) remained ≥ 90 mm Hg (1 mm Hg = 0.133 kPa) were randomly divided into benazepril 10 mg/amlodipine 5 mg (BZ10/AML5) fixed-dose combination therapy group (once a day, n = 113), and benazepril monotherapy group (daily 20 mg, n = 107). In the two groups the patients with SeDBP ≥ 90 mm Hg were doubled the dosage of the initial regimen at the end of 4-week treatment for additional 4 weeks, and the patients with SeDBP benazepril/amlodipine (10 mg/5 mg) and benazepril (20 mg) alone were 83.1%/76.0% and 85.8%/79.5%, respectively. Adverse events rates were 16.8% in the combination therapy group and 35.5% in the monotherapy group (P benazepril/amlodipine was superior to benazepril monotherapy and was well tolerated in patients with essential hypertension and allowing a satisfactory BP control for 24 hours.

  13. 3D 14N/1H Double Quantum/1H Single Quantum Correlation Solid-State NMR for Probing Parallel and Anti-Parallel Beta-Sheet Arrangement of Oligo-Peptides at Natural Abundance.

    Science.gov (United States)

    Hong, You-Lee; Asakura, Tetsuo; Nishiyama, Yusuke

    2018-05-08

    β-sheet structure of oligo- and poly-peptides can be formed in anti-parallel (AP)- and parallel (P)-structure, which is the important feature to understand the structures. In principle, P- and AP-β-sheet structures can be identified by the presence (AP) and absence (P) of the interstrand 1HNH/1HNH correlations on a diagonal in 2D 1H double quantum (DQ)/1H single quantum (SQ) spectrum due to the different interstrand 1HNH/1HNH distances between these two arrangements. However, the 1HNH/1HNH peaks overlap to the 1HNH3+/1HNH3+ peaks, which always give cross peaks regardless of the β-sheet arrangement. The 1HNH3+/1HNH3+ peaks disturb the observation of the presence/absence of 1HNH/1HNH correlations and the assignment of 1HNH and 1HNH3+ is not always available. Here, 3D 14N/1H DQ/1H SQ correlation solid-state NMR experiments at fast magic angle spinning (70 kHz) are introduced to distinguish AP and P β-sheet structure. The 14N dimension allows the separate observation of 1HNH/1HNH peaks from 1HNH3+/1HNH3+ peaks with clear assignment of 1HNH and 1HNH3+. In addition, the high natural abundance of 1H and 14N enables 3D 14N/1H DQ/1H SQ experiments of oligo-alanines (Ala3-6) in four hours without any isotope labelling. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Exergy and Exergoenvironmental Analysis of a CCHP System Based on a Parallel Flow Double-Effect Absorption Chiller

    Directory of Open Access Journals (Sweden)

    Ali Mousafarash

    2016-01-01

    Full Text Available A combined cooling, heating, and power (CCHP system which produces electricity, heating, and cooling is modeled and analyzed. This system is comprised of a gas turbine, a heat recovery steam generator, and a double-effect absorption chiller. Exergy analysis is conducted to address the magnitude and the location of irreversibilities. In order to enhance understanding, a comprehensive parametric study is performed to see the effect of some major design parameters on the system performance. These design parameters are compressor pressure ratio, gas turbine inlet temperature, gas turbine isentropic efficiency, compressor isentropic efficiency, and temperature of absorption chiller generator inlet. The results show that exergy efficiency of the CCHP system is higher than the power generation system and the cogeneration system. In addition, the results indicate that when waste heat is utilized in the heat recovery steam generator, the greenhouse gasses are reduced when the fixed power output is generated. According to the parametric study results, an increase in compressor pressure ratio shows that the network output first increases and then decreases. Furthermore, an increase in gas turbine inlet temperature increases the system exergy efficiency, decreasing the total exergy destruction rate consequently.

  15. Naproxen and aspirin in acute musculoskeletal disorders: a double-blind, parallel study in patients with sports injuries.

    Science.gov (United States)

    Andersen, L A; Gøtzsche, P C

    1984-01-01

    Seventy-nine patients with injuries of less than 14-days' duration were treated with either 750 mg naproxen or 2 g acetylsalicylic acid daily for 7 days in a double-blind trial. A statistically significant improvement (p less than 0.001) was noted in both treatment groups in respect of tenderness on palpation, pain on movement and functional capacity. However, there were no significant differences between the groups. Fresh injuries were over-represented in the acetylsalicylic acid group (p less than 0.01), and when all patients were analyzed together, a significantly better treatment result was obtained the shorter the interval between injury and start of treatment. This might have influenced the results from this study. Fifteen side-effects were reported by 11 patients, 5 in the naproxen group and 6 in the acetylsalicylic acid group. None was serious, and only 2 patients interrupted the treatment for this reason. It is suggested that treatment with analgesics or anti-inflammatory drugs should start as early as possible after the injury.

  16. Explicit symplectic algorithms based on generating functions for charged particle dynamics

    Science.gov (United States)

    Zhang, Ruili; Qin, Hong; Tang, Yifa; Liu, Jian; He, Yang; Xiao, Jianyuan

    2016-07-01

    Dynamics of a charged particle in the canonical coordinates is a Hamiltonian system, and the well-known symplectic algorithm has been regarded as the de facto method for numerical integration of Hamiltonian systems due to its long-term accuracy and fidelity. For long-term simulations with high efficiency, explicit symplectic algorithms are desirable. However, it is generally believed that explicit symplectic algorithms are only available for sum-separable Hamiltonians, and this restriction limits the application of explicit symplectic algorithms to charged particle dynamics. To overcome this difficulty, we combine the familiar sum-split method and a generating function method to construct second- and third-order explicit symplectic algorithms for dynamics of charged particle. The generating function method is designed to generate explicit symplectic algorithms for product-separable Hamiltonian with form of H (x ,p ) =pif (x ) or H (x ,p ) =xig (p ) . Applied to the simulations of charged particle dynamics, the explicit symplectic algorithms based on generating functions demonstrate superiorities in conservation and efficiency.

  17. Arthroscopically assisted stabilization of acute high-grade acromioclavicular joint separations in a coracoclavicular Double-TightRope technique: V-shaped versus parallel drill hole orientation.

    Science.gov (United States)

    Kraus, Natascha; Haas, Norbert P; Scheibel, Markus; Gerhardt, Christian

    2013-10-01

    The arthroscopically assisted Double-TightRope technique has recently been reported to yield good to excellent clinical results in the treatment of acute, high-grade acromioclavicular dislocation. However, the orientation of the transclavicular-transcoracoidal drill holes remains a matter of debate. A V-shaped drill hole orientation leads to better clinical and radiologic results and provides a higher vertical and horizontal stability compared to parallel drill hole placement. This was a cohort study; level of evidence, 2b. Two groups of patients with acute high-grade acromioclavicular joint instability (Rockwood type V) were included in this prospective, non-randomized cohort study. 15 patients (1 female/14 male) with a mean age of 37.7 (18-66) years were treated with a Double-TightRope technique using a V-shaped orientation of the drill holes (group 1). 13 patients (1 female/12 male) with a mean age of 40.9 (21-59) years were treated with a Double-TightRope technique with a parallel drill hole placement (group 2). After 2 years, the final evaluation consisted of a complete physical examination of both shoulders, evaluation of the Subjective Shoulder Value (SSV), Constant Score (CS), Taft Score (TF) and Acromioclavicular Joint Instability Score (ACJI) as well as a radiologic examination including bilateral anteroposterior stress views and bilateral Alexander views. After a mean follow-up of 2 years, all patients were free of shoulder pain at rest and during daily activities. Range of motion did not differ significantly between both groups (p > 0.05). Patients in group 1 reached on average 92.4 points in the CS, 96.2 % in the SSV, 10.5 points in the TF and 75.9 points in the ACJI. Patients in group 2 scored 90.5 points in the CS, 93.9 % in the SSV, 10.5 points in the TF and 84.5 points in the ACJI (p > 0.05). Radiographically, the coracoclavicular distance was found to be 13.9 mm (group 1) and 13.4 mm (group 2) on the affected side and 9.3 mm (group 1

  18. Exploratory double-blind, parallel-group, placebo-controlled extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis.

    Science.gov (United States)

    2017-10-01

    Following the first phase III study of edaravone for amyotrophic lateral sclerosis (ALS), this extension study was performed to evaluate longer-term efficacy and safety. Patients given edaravone in the first 24-week phase III study (Cycles 1-6) were randomised to edaravone (E-E) or placebo (E-P) in the subsequent 24-week double-blind period (Cycles 7-12). Patients given placebo in phase III were switched to edaravone (P-E). Subsequently, all patients received edaravone for 12 weeks (Cycles 13-15). Efficacy endpoints included revised ALS Functional Rating Scale (ALSFRS-R) score. Analysis populations were the full analysis set (FAS) and the efficacy-expected subpopulation (EESP) defined by post-hoc analysis of the first phase III study. The least-squares mean and standard error of the intergroup difference (E-E vs. E-P) of change in the ALSFRS-R score from Cycles 7-12 was 1.16 ± 0.93 (p = 0.2176) in the FAS, and 1.85 ± 1.14 (p = 0.1127) in the EESP. The ALSFRS-R score changed almost linearly in the E-E group throughout Cycles 1-15 (60 weeks). The incidence of serious adverse events associated with ALS progression was higher in E-E than in E-P. Edaravone might have potential efficacy for up to 15 cycles when used to treat patients in the EESP with careful safety monitoring.

  19. Symplectic and semiclassical aspects of the Schläfli identity

    Science.gov (United States)

    Hedeman, Austin; Kur, Eugene; Littlejohn, Robert G.; Haggard, Hal M.

    2015-03-01

    The Schläfli identity, which is important in Regge calculus and loop quantum gravity, is examined from a symplectic and semiclassical standpoint in the special case of flat, three-dimensional space. In this case a proof is given, based on symplectic geometry. A series of symplectic and Lagrangian manifolds related to the Schläfli identity, including several versions of a Lagrangian manifold of tetrahedra, are discussed. Semiclassical interpretations of the various steps are provided. Possible generalizations to three-dimensional spaces of constant (nonzero) curvature, involving Poisson-Lie groups and q-deformed spin networks, are discussed.

  20. New results for time reversed symplectic dynamic systems and quadratic functionals

    Directory of Open Access Journals (Sweden)

    Roman Simon Hilscher

    2012-05-01

    Full Text Available In this paper, we examine time scale symplectic (or Hamiltonian systems and the associated quadratic functionals which contain a forward shift in the time variable. Such systems and functionals have a close connection to Jacobi systems for calculus of variations and optimal control problems on time scales. Our results, among which we consider the Reid roundabout theorem, generalize the corresponding classical theory for time reversed discrete symplectic systems, as well as they complete the recently developed theory of time scale symplectic systems.

  1. A symplectic Poisson solver based on Fast Fourier Transformation. The first trial

    International Nuclear Information System (INIS)

    Vorobiev, L.G.; Hirata, Kohji.

    1995-11-01

    A symplectic Poisson solver calculates numerically a potential and fields due to a 2D distribution of particles in a way that the symplecticity and smoothness are assured automatically. Such a code, based on Fast Fourier Transformation combined with Bicubic Interpolation, is developed for the use in multi-turn particle simulation in circular accelerators. Beside that, it may have a number of applications, where computations of space charge forces should obey a symplecticity criterion. Detailed computational schemes of all algorithms will be outlined to facilitate practical programming. (author)

  2. Existence and equivalence of twisted products on a symplectic manifold

    International Nuclear Information System (INIS)

    Lichnerowicz, A.

    1979-01-01

    The twisted products play an important role in Quantum Mechanics. A distinction is introduced between Vey *sub(γ) products and strong Vey *sub(γ) products and it is proved that each *sub(γ) product is equivalent to a Vey *sub(γ) product. If b 3 (W) = 0, the symplectic manifold (W,F) admits strong Vey *sub(Gn) products. If b 2 (W) = 0, all *sub(γ) products are equivalent as well as the Vey Lie algebras. In the general case the formal Lie algebras are characterized which are generated by a *sub(γ) product and it proved that the existance of a *sub(γ)-product is equivalent to the existance of a formal Lie algebra infinitesimally equivalent to a Vey Lie algebra at the first order. (Auth.)

  3. Symplectic maps and chromatic optics in particle accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai

    2015-10-11

    We have applied the nonlinear map method to comprehensively characterize the chromatic optics in particle accelerators. Our approach is built on the foundation of symplectic transfer maps of magnetic elements. The chromatic lattice parameters can be transported from one element to another by the maps. We introduce a Jacobian operator that provides an intrinsic linkage between the maps and the matrix with parameter dependence. The link allows us to directly apply the formulation of the linear optics to compute the chromatic lattice parameters. As an illustration, we analyze an alternating-gradient cell with nonlinear sextupoles, octupoles, and decapoles and derive analytically their settings for the local chromatic compensation. As a result, the cell becomes nearly perfect up to the third-order of the momentum deviation.

  4. Notes on qubit phase space and discrete symplectic structures

    International Nuclear Information System (INIS)

    Livine, Etera R

    2010-01-01

    We start from Wootter's construction of discrete phase spaces and Wigner functions for qubits and more generally for finite-dimensional Hilbert spaces. We look at this framework from a non-commutative space perspective and we focus on the Moyal product and the differential calculus on these discrete phase spaces. In particular, the qubit phase space provides the simplest example of a four-point non-commutative phase space. We give an explicit expression of the Moyal bracket as a differential operator. We then compare the quantum dynamics encoded by the Moyal bracket to the classical dynamics: we show that the classical Poisson bracket does not satisfy the Jacobi identity thus leaving the Moyal bracket as the only consistent symplectic structure. We finally generalize our analysis to Hilbert spaces of prime dimensions d and their associated d x d phase spaces.

  5. Chern-Simons theories of symplectic super-diffeomorphisms

    International Nuclear Information System (INIS)

    Sezgin, E.; Sokatchev, E.

    1989-04-01

    We discuss the symplectic diffeomorphisms of a class of supermanifolds and the structure of the underlying infinite dimensional superalgebras. We construct a Chern-Simons (CS) gauge theory in 2+1 dimensions for these algebras. There exists a finite dimensional supersymmetric truncation which is the (2 n -1)-dimensional Hamiltonian superalgebra H-tilde(n). With a central charge added, it is a superalgebra, C(n), associated with a Clifford algebra. We find an embedding of d=3, N=2 anti-de Sitter superalgebra OSp(2|2)+OSp(2|2) in C(4), and construct a CS action for its infinite dimensional extension. We also discuss the construction of a CS action for the infinite dimensional extension of the d=3, N=2 superconformal algebra OSp(2,4). (author). 18 refs

  6. Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies

    DEFF Research Database (Denmark)

    Kajdasz, Daniel K; Iyengar, Smriti; Desaiah, Durisala

    2007-01-01

    peripheral neuropathic pain (DPNP). METHODS: Data were pooled from three 12-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies in which patients received 60 mg duloxetine either QD or BID or placebo. NNT was calculated based on rates of response (defined as >or=30...

  7. An A Posteriori Error Estimate for Symplectic Euler Approximation of Optimal Control Problems

    KAUST Repository

    Karlsson, Peer Jesper; Larsson, Stig; Sandberg, Mattias; Szepessy, Anders; Tempone, Raul

    2015-01-01

    This work focuses on numerical solutions of optimal control problems. A time discretization error representation is derived for the approximation of the associated value function. It concerns Symplectic Euler solutions of the Hamiltonian system

  8. Normal forms for Poisson maps and symplectic groupoids around Poisson transversals.

    Science.gov (United States)

    Frejlich, Pedro; Mărcuț, Ioan

    2018-01-01

    Poisson transversals are submanifolds in a Poisson manifold which intersect all symplectic leaves transversally and symplectically. In this communication, we prove a normal form theorem for Poisson maps around Poisson transversals. A Poisson map pulls a Poisson transversal back to a Poisson transversal, and our first main result states that simultaneous normal forms exist around such transversals, for which the Poisson map becomes transversally linear, and intertwines the normal form data of the transversals. Our second result concerns symplectic integrations. We prove that a neighborhood of a Poisson transversal is integrable exactly when the Poisson transversal itself is integrable, and in that case we prove a normal form theorem for the symplectic groupoid around its restriction to the Poisson transversal, which puts all structure maps in normal form. We conclude by illustrating our results with examples arising from Lie algebras.

  9. Two new solutions to the third-order symplectic integration method

    International Nuclear Information System (INIS)

    Iwatsu, Reima

    2009-01-01

    Two new solutions are obtained for the symplecticity conditions of explicit third-order partitioned Runge-Kutta time integration method. One of them has larger stability limit and better dispersion property than the Ruth's method.

  10. Variational and symplectic integrators for satellite relative orbit propagation including drag

    Science.gov (United States)

    Palacios, Leonel; Gurfil, Pini

    2018-04-01

    Orbit propagation algorithms for satellite relative motion relying on Runge-Kutta integrators are non-symplectic—a situation that leads to incorrect global behavior and degraded accuracy. Thus, attempts have been made to apply symplectic methods to integrate satellite relative motion. However, so far all these symplectic propagation schemes have not taken into account the effect of atmospheric drag. In this paper, drag-generalized symplectic and variational algorithms for satellite relative orbit propagation are developed in different reference frames, and numerical simulations with and without the effect of atmospheric drag are presented. It is also shown that high-order versions of the newly-developed variational and symplectic propagators are more accurate and are significantly faster than Runge-Kutta-based integrators, even in the presence of atmospheric drag.

  11. Exact symplectic structures and a classical model for the Dirac electron

    International Nuclear Information System (INIS)

    Rawnsley, J.

    1992-01-01

    We show how the classical model for the Dirac electron of Barut and coworkers can be obtained as a Hamiltonian theory by constructing an exact symplectic form on the total space of the spin bundle over spacetime. (orig.)

  12. On the Inverse Mapping of the Formal Symplectic Groupoid of a Deformation Quantization

    Science.gov (United States)

    Karabegov, Alexander V.

    2004-10-01

    To each natural star product on a Poisson manifold $M$ we associate an antisymplectic involutive automorphism of the formal neighborhood of the zero section of the cotangent bundle of $M$. If $M$ is symplectic, this mapping is shown to be the inverse mapping of the formal symplectic groupoid of the star product. The construction of the inverse mapping involves modular automorphisms of the star product.

  13. Symplectic matrix, gauge invariance and Dirac brackets for super-QED

    Energy Technology Data Exchange (ETDEWEB)

    Alves, D.T. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Cheb-Terrab, E.S. [British Columbia Univ., Vancouver, BC (Canada). Dept. of Mathematics

    1999-08-01

    The calculation of Dirac brackets (DB) using a symplectic matrix approach but in a Hamiltonian framework is discussed, and the calculation of the DB for the supersymmetric extension of QED (super-QED) is shown. The relation between the zero-mode of the pre-symplectic matrix and the gauge transformations admitted by the model is verified. A general description to construct Lagrangians linear in the velocities is also presented. (author)

  14. Application of Symplectic Algebraic Dynamics Algorithm to Circular Restricted Three-Body Problem

    International Nuclear Information System (INIS)

    Wei-Tao, Lu; Hua, Zhang; Shun-Jin, Wang

    2008-01-01

    Symplectic algebraic dynamics algorithm (SADA) for ordinary differential equations is applied to solve numerically the circular restricted three-body problem (CR3BP) in dynamical astronomy for both stable motion and chaotic motion. The result is compared with those of Runge–Kutta algorithm and symplectic algorithm under the fourth order, which shows that SADA has higher accuracy than the others in the long-term calculations of the CR3BP. (general)

  15. GENERAL: Application of Symplectic Algebraic Dynamics Algorithm to Circular Restricted Three-Body Problem

    Science.gov (United States)

    Lu, Wei-Tao; Zhang, Hua; Wang, Shun-Jin

    2008-07-01

    Symplectic algebraic dynamics algorithm (SADA) for ordinary differential equations is applied to solve numerically the circular restricted three-body problem (CR3BP) in dynamical astronomy for both stable motion and chaotic motion. The result is compared with those of Runge-Kutta algorithm and symplectic algorithm under the fourth order, which shows that SADA has higher accuracy than the others in the long-term calculations of the CR3BP.

  16. Variational symplectic algorithm for guiding center dynamics and its application in tokamak geometry

    International Nuclear Information System (INIS)

    Qin Hong; Guan Xiaoyin; Tang, William M.

    2009-01-01

    A variational symplectic integrator for the guiding center motion of charged particles in general magnetic fields is developed to enable accurate long-time simulation studies of magnetized plasmas. Instead of discretizing the differential equations of the guiding center motion, the action of the guiding center motion is discretized and minimized to obtain the iteration rules for advancing the dynamics. The variational symplectic integrator conserves exactly a discrete Lagrangian symplectic structure and globally bounds the numerical error in energy by a small number for all simulation time steps. Compared with standard integrators, such as the fourth order Runge-Kutta method, the variational symplectic integrator has superior numerical properties over long integration time. For example, in a two-dimensional tokamak geometry, the variational symplectic integrator is able to guarantee the accuracy for both the trapped and transit particle orbits for arbitrarily long simulation time. This is important for modern large-scale simulation studies of fusion plasmas where it is critical to use algorithms with long-term accuracy and fidelity. The variational symplectic integrator is expected to have a wide range of applications.

  17. Evaluation of efficacy of a commercially available herbal mouthwash on dental plaque and gingivitis: A double-blinded parallel randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Sanjukta Bagchi

    2015-01-01

    Full Text Available Aim: To evaluate if a commercially available herbal mouthwash, can be a better choice as an anti-plaque and antigingivitis agent when compared with chlorhexidine. Materials and Methods: In a double-blind, parallel group randomized clinical trial 90 nursing students aged 18-25 years were randomly divided into three groups: A (chlorhexidine, B (HiOra and C (distilled water. These groups were asked to rinse with their respective mouthwash two times daily for 21 days. Plaque and gingivitis were evaluated by using Turesky et al. modification of Quigley Hein Plaque Index (1970 and Modified Gingival Index by Lobene et al. (1986 respectively. Statistical analysis was done using ANOVA test. Results: There was statistically significant reduction in plaque and gingival scores from baseline to 21 days in both the groups A and B. Conclusions: Although chlorhexidine group proved to be the best anti-plaque and antigingivitis agent, it was found that HiOra group also showed gradual improvement from baseline to 21 days. Whereas no improvement was seen in the Group C using distilled water over 21 days.

  18. Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD A double-blind, randomised, non-inferiority, parallel-group, multicentre study

    Directory of Open Access Journals (Sweden)

    Andersson Eva

    2009-02-01

    Full Text Available Abstract Background Oral corticosteroids and inhaled bronchodilators with or without antibiotics represent standard treatment of COPD exacerbations of moderate severity. Frequent courses of oral steroids may be a safety issue. We wanted to evaluate in an out-patient setting whether a 2-week course of inhaled budesonide/formoterol would be equally effective for treatment of acute COPD exacerbations as standard therapy in patients judged by the investigator not to require hospitalisation. Methods This was a double-blind, randomised, non-inferiority, parallel-group, multicentre study comparing two treatment strategies; two weeks' treatment with inhaled budesonide/formoterol (320/9 μg, qid was compared with prednisolone (30 mg once daily plus inhaled formoterol (9 μg bid in patients with acute exacerbations of COPD attending a primary health care centre. Inclusion criteria were progressive dyspnoea for less than one week, FEV1 30–60% of predicted normal after acute treatment with a single dose of oral corticosteroid plus nebulised salbutamol/ipratropium bromide and no requirement for subsequent immediate hospitalisation, i.e the clinical status after the acute treatment allowed for sending the patient home. A total of 109 patients (mean age 67 years, 33 pack-years, mean FEV1 45% of predicted were randomized to two weeks' double-blind treatment with budesonide/formoterol or prednisolone plus formoterol and subsequent open-label budesonide/formoterol (320/9 μg bid for another 12 weeks. Change in FEV1 was the primary efficacy variable. Non-inferiority was predefined. Results Non-inferiority of budesonide/formoterol was proven because the lower limit of FEV1-change (97.5% CI was above 90% of the efficacy of the alternative treatment. Symptoms, quality of life, treatment failures, need for reliever medication (and exacerbations during follow-up did not differ between the groups. No safety concerns were identified. Conclusion High dose budesonide

  19. Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in topical treatment of eczema

    Directory of Open Access Journals (Sweden)

    Gandy JJ

    2011-09-01

    Full Text Available Justin J Gandy, Jacques R Snyman, Constance EJ van RensburgDepartment of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South AfricaBackground: The purpose of this study was to evaluate the efficacy and safety of carbohydrate-derived fulvic acid (CHD-FA in the treatment of eczema in patients two years and older.Methods: In this single-center, double-blind, placebo-controlled, parallel-group comparative study, 36 volunteers with predetermined eczema were randomly assigned to receive either the study drug or placebo twice daily for four weeks.Results: All safety parameters remained within normal limits, with no significant differences in either group. Significant differences were observed for both severity and erythema in the placebo and CHD-FA treated groups, and a significant difference was observed for scaling in the placebo-treated group. With regard to the investigator assessment of global response to treatment, a significant improvement was observed in the CHD-FA group when compared with the placebo group. A statistically significant decrease in visual analog scale score was observed in both groups, when comparing the baseline with the final results.Conclusion: CHD-FA was well tolerated, with no difference in reported side effects other than a short-lived burning sensation on application. CHD-FA significantly improved some aspects of eczema. Investigator assessment of global response to treatment with CHD-FA was significantly better than that with emollient therapy alone. The results of this small exploratory study suggest that CHD-FA warrants further investigation in the treatment of eczema.Keywords: fulvic acid, eczema, anti-inflammatory, efficacy, safety

  20. A randomised, double blind, placebo-controlled, multi-centric parallel arm trial to assess the effects of homoeopathic medicines on chronic rhinosinusitis

    Directory of Open Access Journals (Sweden)

    Raj K Manchanda

    2014-01-01

    Full Text Available Background: Chronic rhinosinusitis (CRS is one of the most common illnesses interfering with patient′s quality of life and work. Observational studies conducted by the Council indicate positive outcome. This protocol has been developed to ascertain the usefulness of homoeopathic intervention in comparison with control group in a randomised control setting. Objectives: Primary objective is to evaluate the changes in TSS (Total Symptoms Score and SNOT-22 (Sino-nasal Outcome Test-22 within the two groups of the study (Homoeopathy + Placebo. Secondary objective is to evaluate changes in SNOT-22 at end of the trial, changes in Lund and Mackay staging of CT scan, rhinoscopy grading, absolute eosinophil count, global assessment by investigator and patient, and number of acute exacerbations of CRS (for frequency, duration and intensity as per TSS scale compared to placebo. Methods/Design: This is a randomised double blind, placebo-controlled, multi-centric parallel arm trial of 6 months (three months treatment and three months observation period with 14 days run-in period. The primary outcome is a composite of the changes in the TSS and SNOT-22 over 3 months from baseline with area under the curve and changes over 3 months in the Sinus Nasal Outcome Test 22 (SNOT-22 from baseline. Prescription shall be made as per the homoeopathic principles. Efficacy data will be analysed in the intention-to-treat population. Discussion: This trial will help to evaluate the efficacy of homoeopathic individualised treatment using LM-potencies versus placebo in patients suffering from CRS as per the homoeopathic dictum.

  1. Improvement of defecation in healthy individuals with infrequent bowel movements through the ingestion of dried Mozuku powder: a randomized, double-blind, parallel-group study

    Directory of Open Access Journals (Sweden)

    Masaki Matayoshi

    2017-09-01

    Full Text Available Background: Okinawa mozuku (Cladosiphon okamuranu is a type of edible seaweed of the family Chordariaceae that typically contains the polysaccharide fucoidan as a functional ingredient. In Okinawa, raw mozuku is eaten as vinegared mozuku together with vinegar or as tempura (deep-fried in batter. Polysaccharides such as fucoidan are generally known to regulate intestinal function, which is why we have used Okinawa mozuku to investigate this intestinal regulatory effect. Methods: The study was designed as a randomized, double-blind, parallel group study. Dried Okinawa mozuku powder at a dose of 2.4 g/day (1.0 g/day of fucoidan and a placebo not containing any dried Okinawa mozuku powder were each made into capsules and given to healthy men and women with infrequent weekly bowel movements (2–4 movements a week to ingest for eight weeks. We then investigated changes in the defecation situation, blood tests, and adverse events. Results: In the group that ingested the capsules containing dried Okinawa mozuku powder, the number of days with a bowel movement significantly increased compared with the placebo group after four weeks of ingestion (p < 0.05. Furthermore, after eight weeks of ingestion, the same increasing trend was seen compared with the placebo group (p = 0.0964. The volume of stool also increased significantly in the dried Okinawa mozuku powder group after eight weeks compared with the placebo group. In terms of blood tests and adverse events, no adverse events occurred that were the result of the test food. Conclusions: Ingestion of Okinawa mozuku was found to have a regulatory effect on intestinal function by promoting defecation in healthy individuals with a tendency for constipation. This demonstrated that Okinawa mozuku is a functional food capable of making defecation smoother and increasing the volume of stool.

  2. [Effect of Xinling Wan in treatment of stable angina pectoris: a randomized, double-blinded, placebo parallel-controlled, multicenter trial].

    Science.gov (United States)

    Gao, Jian-Wei; Gao, Xue-Min; Zou, Ting; Zhao, Tian-Meng; Wang, Dong-Hua; Wu, Zong-Gui; Ren, Chang-Jie; Wang, Xing; Geng, Nai-Zhi; Zhao, Ming-Jun; Liang, Qiu-Ming; Feng, Xing; Yang, Bai-Song; Shi, Jun-Ling; Hua, Qi

    2018-03-01

    To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris, a randomized, double-blinded, placebo parallel-controlled, multicenter clinical trial was conducted. A total of 232 subjects were enrolled and randomly divided into experiment group and placebo group. The experiment group was treated with Xinling Wan (two pills each time, three times daily) for 4 weeks, and the placebo group was treated with placebo. The effectiveness evaluation showed that Xinling Wan could significantly increase the total duration of treadmill exercise among patients with stable angina pectoris. FAS analysis showed that the difference value of the total exercise duration was between experiment group (72.11±139.32) s and placebo group (31.25±108.32) s. Xinling Wan could remarkably increase the total effective rate of angina pectoris symptom score, and the analysis showed that the total effective rate was 78.95% in experiment group and 42.61% in placebo group. The reduction of nitroglycerin dose was (2.45±2.41) tablets in experiment group and (0.50±2.24) tablets in placebo group on the basis of FAS analysis. The decrease of symptom integral was (4.68±3.49) in experiment group and (3.19±3.31) in placebo group based on FAS analysis. Besides, Xinling Wan could decrease the weekly attack time and the duration of angina pectoris. PPS analysis results were similar to those of FAS analysis. In conclusion, Xinling Wan has an obvious therapeutic effect in treating stable angina pectoris, with a good safety and a low incidence of adverse event and adverse reaction in experiment group. Copyright© by the Chinese Pharmaceutical Association.

  3. Evaluation of pulsing magnetic field effects on paresthesia in multiple sclerosis patients, a randomized, double-blind, parallel-group clinical trial.

    Science.gov (United States)

    Afshari, Daryoush; Moradian, Nasrin; Khalili, Majid; Razazian, Nazanin; Bostani, Arash; Hoseini, Jamal; Moradian, Mohamad; Ghiasian, Masoud

    2016-10-01

    Evidence is mounting that magnet therapy could alleviate the symptoms of multiple sclerosis (MS). This study was performed to test the effects of the pulsing magnetic fields on the paresthesia in MS patients. This study has been conducted as a randomized, double-blind, parallel-group clinical trial during the April 2012 to October 2013. The subjects were selected among patients referred to MS clinic of Imam Reza Hospital; affiliated to Kermanshah University of Medical Sciences, Iran. Sixty three patients with MS were included in the study and randomly were divided into two groups, 35 patients were exposed to a magnetic pulsing field of 4mT intensity and 15-Hz frequency sinusoidal wave for 20min per session 2 times per week over a period of 2 months involving 16 sessions and 28 patients was exposed to a magnetically inactive field (placebo) for 20min per session 2 times per week over a period of 2 months involving 16 sessions. The severity of paresthesia was measured by the numerical rating scale (NRS) at 30, 60days. The study primary end point was NRS change between baseline and 60days. The secondary outcome was NRS change between baseline and 30days. Patients exposing to magnetic field showed significant paresthesia improvement compared with the group of patients exposing to placebo. According to our results pulsed magnetic therapy could alleviate paresthesia in MS patients .But trials with more patients and longer duration are mandatory to describe long-term effects. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. The effect of a corticosteroid cream and a barrier-strengthening moisturizer in hand eczema. A double-blind, randomized, prospective, parallel group clinical trial.

    Science.gov (United States)

    Lodén, M; Wirén, K; Smerud, K T; Meland, N; Hønnås, H; Mørk, G; Lützow-Holm, C; Funk, J; Meding, B

    2012-05-01

    Hand eczema is a common and persistent disease with a relapsing course. Clinical data suggest that once daily treatment with corticosteroids is just as effective as twice daily treatment. The aim of this study was to compare once and twice daily applications of a strong corticosteroid cream in addition to maintenance therapy with a moisturizer in patients with a recent relapse of hand eczema. The study was a parallel, double-blind, randomized, clinical trial on 44 patients. Twice daily application of a strong corticosteroid cream (betamethasone valerate 0.1%) was compared with once daily application, where a urea-containing moisturizer was substituted for the corticosteroid cream in the morning. The investigator scored the presence of eczema and the patients judged the health-related quality of life (HRQoL) using the Dermatology Life Quality Index (DLQI), which measures how much the patient's skin problem has affected his/her life over the past week. The patients also judged the severity of their eczema daily on a visual analogue scale. Both groups improved in terms of eczema and DLQI. However, the clinical scoring demonstrated that once daily application of corticosteroid was superior to twice daily application in diminishing eczema, especially in the group of patients with lower eczema scores at inclusion. Twice daily use of corticosteroids was not superior to once daily use in treating eczema. On the contrary, the clinical assessment showed a larger benefit from once daily treatment compared with twice daily, especially in the group of patients with a moderate eczema at inclusion. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

  5. Highly accurate symplectic element based on two variational principles

    Science.gov (United States)

    Qing, Guanghui; Tian, Jia

    2018-02-01

    For the stability requirement of numerical resultants, the mathematical theory of classical mixed methods are relatively complex. However, generalized mixed methods are automatically stable, and their building process is simple and straightforward. In this paper, based on the seminal idea of the generalized mixed methods, a simple, stable, and highly accurate 8-node noncompatible symplectic element (NCSE8) was developed by the combination of the modified Hellinger-Reissner mixed variational principle and the minimum energy principle. To ensure the accuracy of in-plane stress results, a simultaneous equation approach was also suggested. Numerical experimentation shows that the accuracy of stress results of NCSE8 are nearly the same as that of displacement methods, and they are in good agreement with the exact solutions when the mesh is relatively fine. NCSE8 has advantages of the clearing concept, easy calculation by a finite element computer program, higher accuracy and wide applicability for various linear elasticity compressible and nearly incompressible material problems. It is possible that NCSE8 becomes even more advantageous for the fracture problems due to its better accuracy of stresses.

  6. The complex Laguerre symplectic ensemble of non-Hermitian matrices

    International Nuclear Information System (INIS)

    Akemann, G.

    2005-01-01

    We solve the complex extension of the chiral Gaussian symplectic ensemble, defined as a Gaussian two-matrix model of chiral non-Hermitian quaternion real matrices. This leads to the appearance of Laguerre polynomials in the complex plane and we prove their orthogonality. Alternatively, a complex eigenvalue representation of this ensemble is given for general weight functions. All k-point correlation functions of complex eigenvalues are given in terms of the corresponding skew orthogonal polynomials in the complex plane for finite-N, where N is the matrix size or number of eigenvalues, respectively. We also allow for an arbitrary number of complex conjugate pairs of characteristic polynomials in the weight function, corresponding to massive quark flavours in applications to field theory. Explicit expressions are given in the large-N limit at both weak and strong non-Hermiticity for the weight of the Gaussian two-matrix model. This model can be mapped to the complex Dirac operator spectrum with non-vanishing chemical potential. It belongs to the symmetry class of either the adjoint representation or two colours in the fundamental representation using staggered lattice fermions

  7. Submaximal Riemann-Roch expected curves and symplectic packing.

    Directory of Open Access Journals (Sweden)

    Wioletta Syzdek

    2007-06-01

    Full Text Available We study Riemann-Roch expected curves on $mathbb{P}^1 imes mathbb{P}^1$ in the context of the Nagata-Biran conjecture. This conjecture predicts that for sufficiently large number of points multiple points Seshadri constants of an ample line bundle on algebraic surface are maximal. Biran gives an effective lower bound $N_0$. We construct examples verifying to the effect that the assertions of the Nagata-Biran conjecture can not hold for small number of points. We discuss cases where our construction fails. We observe also that there exists a strong relation between Riemann-Roch expected curves on $mathbb{P}^1 imes mathbb{P}^1$ and the symplectic packing problem. Biran relates the packing problem to the existence of solutions of certain Diophantine equations. We construct such solutions for any ample line bundle on $mathbb{P}^1 imes mathbb{P}^1$ and a relatively smallnumber of points. The solutions geometrically correspond to Riemann-Roch expected curves. Finally we discuss in how far the Biran number $N_0$ is optimal in the case of mathbb{P}^1 imes mathbb{P}^1. In fact we conjecture that it can be replaced by a lower number and we provide evidence justifying this conjecture.

  8. Seismic wavefield modeling based on time-domain symplectic and Fourier finite-difference method

    Science.gov (United States)

    Fang, Gang; Ba, Jing; Liu, Xin-xin; Zhu, Kun; Liu, Guo-Chang

    2017-06-01

    Seismic wavefield modeling is important for improving seismic data processing and interpretation. Calculations of wavefield propagation are sometimes not stable when forward modeling of seismic wave uses large time steps for long times. Based on the Hamiltonian expression of the acoustic wave equation, we propose a structure-preserving method for seismic wavefield modeling by applying the symplectic finite-difference method on time grids and the Fourier finite-difference method on space grids to solve the acoustic wave equation. The proposed method is called the symplectic Fourier finite-difference (symplectic FFD) method, and offers high computational accuracy and improves the computational stability. Using acoustic approximation, we extend the method to anisotropic media. We discuss the calculations in the symplectic FFD method for seismic wavefield modeling of isotropic and anisotropic media, and use the BP salt model and BP TTI model to test the proposed method. The numerical examples suggest that the proposed method can be used in seismic modeling of strongly variable velocities, offering high computational accuracy and low numerical dispersion. The symplectic FFD method overcomes the residual qSV wave of seismic modeling in anisotropic media and maintains the stability of the wavefield propagation for large time steps.

  9. EXPLICIT SYMPLECTIC-LIKE INTEGRATORS WITH MIDPOINT PERMUTATIONS FOR SPINNING COMPACT BINARIES

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Junjie; Wu, Xin; Huang, Guoqing [Department of Physics and Institute of Astronomy, Nanchang University, Nanchang 330031 (China); Liu, Fuyao, E-mail: xwu@ncu.edu.cn [School of Fundamental Studies, Shanghai University of Engineering Science, Shanghai 201620 (China)

    2017-01-01

    We refine the recently developed fourth-order extended phase space explicit symplectic-like methods for inseparable Hamiltonians using Yoshida’s triple product combined with a midpoint permuted map. The midpoint between the original variables and their corresponding extended variables at every integration step is readjusted as the initial values of the original variables and their corresponding extended ones at the next step integration. The triple-product construction is apparently superior to the composition of two triple products in computational efficiency. Above all, the new midpoint permutations are more effective in restraining the equality of the original variables and their corresponding extended ones at each integration step than the existing sequent permutations of momenta and coordinates. As a result, our new construction shares the benefit of implicit symplectic integrators in the conservation of the second post-Newtonian Hamiltonian of spinning compact binaries. Especially for the chaotic case, it can work well, but the existing sequent permuted algorithm cannot. When dissipative effects from the gravitational radiation reaction are included, the new symplectic-like method has a secular drift in the energy error of the dissipative system for the orbits that are regular in the absence of radiation, as an implicit symplectic integrator does. In spite of this, it is superior to the same-order implicit symplectic integrator in accuracy and efficiency. The new method is particularly useful in discussing the long-term evolution of inseparable Hamiltonian problems.

  10. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

    OpenAIRE

    Rascol, O.; Brooks, D.J.; Melamed, E.; Oertel, W.; Poewe, W.; Stocchi, F.; Tolosa, E.; LARGO study group

    2005-01-01

    Lancet. 2005 Mar 12-18;365(9463):947-54. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Rascol O, Brooks DJ, Melamed E, Oertel W, Poewe W, Stocchi F, Tolosa E; LARGO study group. Clinical Investigation Centre, Department of Clinical Pharmacology, University Hospital, Toulouse, France. ...

  11. A general symplectic method for the response analysis of infinitely periodic structures subjected to random excitations

    Directory of Open Access Journals (Sweden)

    You-Wei Zhang

    Full Text Available A general symplectic method for the random response analysis of infinitely periodic structures subjected to stationary/non-stationary random excitations is developed using symplectic mathematics in conjunction with variable separation and the pseudo-excitation method (PEM. Starting from the equation of motion for a single loaded substructure, symplectic analysis is firstly used to eliminate the dependent degrees of the freedom through condensation. A Fourier expansion of the condensed equation of motion is then applied to separate the variables of time and wave number, thus enabling the necessary recurrence scheme to be developed. The random response is finally determined by implementing PEM. The proposed method is justified by comparison with results available in the literature and is then applied to a more complicated time-dependent coupled system.

  12. Symplectic geometry of field theories and covariant quantization of superstrings and superparticles

    International Nuclear Information System (INIS)

    Crnkovic, C.

    1987-01-01

    A detailed development of the symplectic geometry formalism for a general Lagrangian field theory is presented. Special attention is paid to the theories with constraints and/or gauge degrees of freedom. Special cases of Yang-Mills theory, general relativity and Witten's string field theory are studied and the generators of (super-) Poincare transformations are derived using their respective symplectic forms. The formalism extends naturally to theories formulated in the superspace. The second part of the thesis deals with issues in covariant quantization. By studying the symplectic geometry of the Green-Schwarz covariant superstring action, we elucidate some aspects of its covariant quantization. We derive the on-shell gauge-fixed action and the equations of motion for all the fields. Finally, turning to Siegel's version of the superparticle action, we perform its BRST quantization

  13. Full-turn symplectic map from a generator in a Fourier-spline basis

    International Nuclear Information System (INIS)

    Berg, J.S.; Warnock, R.L.; Ruth, R.D.; Forest, E.

    1993-04-01

    Given an arbitrary symplectic tracking code, one can construct a full-turn symplectic map that approximates the result of the code to high accuracy. The map is defined implicitly by a mixed-variable generating function. The implicit definition is no great drawback in practice, thanks to an efficient use of Newton's method to solve for the explicit map at each iteration. The generator is represented by a Fourier series in angle variables, with coefficients given as B-spline functions of action variables. It is constructed by using results of single-turn tracking from many initial conditions. The method has been appliedto a realistic model of the SSC in three degrees of freedom. Orbits can be mapped symplectically for 10 7 turns on an IBM RS6000 model 320 workstation, in a run of about one day

  14. Constrained dynamics of two interacting relativistic particles in the Faddeev-Jackiw symplectic framework

    Science.gov (United States)

    Rodríguez-Tzompantzi, Omar

    2018-05-01

    The Faddeev-Jackiw symplectic formalism for constrained systems is applied to analyze the dynamical content of a model describing two massive relativistic particles with interaction, which can also be interpreted as a bigravity model in one dimension. We systematically investigate the nature of the physical constraints, for which we also determine the zero-modes structure of the corresponding symplectic matrix. After identifying the whole set of constraints, we find out the transformation laws for all the set of dynamical variables corresponding to gauge symmetries, encoded in the remaining zero modes. In addition, we use an appropriate gauge-fixing procedure, the conformal gauge, to compute the quantization brackets (Faddeev-Jackiw brackets) and also obtain the number of physical degree of freedom. Finally, we argue that this symplectic approach can be helpful for assessing physical constraints and understanding the gauge structure of theories of interacting spin-2 fields.

  15. Multi-symplectic variational integrators for nonlinear Schrödinger equations with variable coefficients

    International Nuclear Information System (INIS)

    Liao Cui-Cui; Cui Jin-Chao; Liang Jiu-Zhen; Ding Xiao-Hua

    2016-01-01

    In this paper, we propose a variational integrator for nonlinear Schrödinger equations with variable coefficients. It is shown that our variational integrator is naturally multi-symplectic. The discrete multi-symplectic structure of the integrator is presented by a multi-symplectic form formula that can be derived from the discrete Lagrangian boundary function. As two examples of nonlinear Schrödinger equations with variable coefficients, cubic nonlinear Schrödinger equations and Gross–Pitaevskii equations are extensively studied by the proposed integrator. Our numerical simulations demonstrate that the integrator is capable of preserving the mass, momentum, and energy conservation during time evolutions. Convergence tests are presented to verify that our integrator has second-order accuracy both in time and space. (paper)

  16. Lactic-fermented egg white reduced serum cholesterol concentrations in mildly hypercholesterolemic Japanese men: a double-blind, parallel-arm design.

    Science.gov (United States)

    Matsuoka, Ryosuke; Usuda, Mika; Masuda, Yasunobu; Kunou, Masaaki; Utsunomiya, Kazunori

    2017-05-30

    Lactic-fermented egg white (LE), produced by lactic acid fermentation of egg white, is an easy-to-consume form of egg white. Here we assessed the effect of daily consumption of LE for 8 weeks on serum total cholesterol (TC) levels. The study followed a double-blind, parallel-arm design and included 88 adult men with mild hypercholesterolemia (mean ± standard error) serum TC levels, 229 ± 1.6 mg/dL; range, 204-259 mg/dL). The subjects were randomly divided into three groups, which consumed LE containing 4, 6, or 8 g of protein daily for 8 weeks. Blood samples were collected before starting LE consumption (baseline) and at 4 and 8 weeks to measure serum TC and low-density lipoprotein cholesterol (LDL-C) levels. After 8 weeks of consumption, serum TC levels in the 8 g group decreased by 11.0 ± 3.7 mg/dL, a significant decrease compared to baseline (p < 0.05) and a significantly greater decrease than for the 4 g group (3.1 ± 3.4 mg/dL; p < 0.05). Serum LDL-C levels in the 8 g group decreased by 13.7 ± 3.1 mg/dL, again a significant decrease compared with baseline (p < 0.05) and a significantly greater decrease than that for the 4 g group (2.1 ± 2.9 mg/dL; p < 0.05). Consumption of LE for 8 weeks at a daily dose of 8 g of proteins reduced serum TC and LDL-C levels in men with mild hypercholesterolemia, suggesting this may be effective in helping to prevent arteriosclerotic diseases. This clinical trial was retrospectively registered with the Japan Medical Association Center for Clinical Trials, (JMA-IIA00279; registered on 13/03/2017; https://dbcentre3.jmacct.med.or.jp/JMACTR/App/JMACTRE02_04/JMACTRE02_04.aspx?kbn=3&seqno=6530 ).

  17. Algebraic dynamics algorithm: Numerical comparison with Runge-Kutta algorithm and symplectic geometric algorithm

    Institute of Scientific and Technical Information of China (English)

    WANG ShunJin; ZHANG Hua

    2007-01-01

    Based on the exact analytical solution of ordinary differential equations,a truncation of the Taylor series of the exact solution to the Nth order leads to the Nth order algebraic dynamics algorithm.A detailed numerical comparison is presented with Runge-Kutta algorithm and symplectic geometric algorithm for 12 test models.The results show that the algebraic dynamics algorithm can better preserve both geometrical and dynamical fidelity of a dynamical system at a controllable precision,and it can solve the problem of algorithm-induced dissipation for the Runge-Kutta algorithm and the problem of algorithm-induced phase shift for the symplectic geometric algorithm.

  18. Algebraic dynamics algorithm:Numerical comparison with Runge-Kutta algorithm and symplectic geometric algorithm

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on the exact analytical solution of ordinary differential equations, a truncation of the Taylor series of the exact solution to the Nth order leads to the Nth order algebraic dynamics algorithm. A detailed numerical comparison is presented with Runge-Kutta algorithm and symplectic geometric algorithm for 12 test models. The results show that the algebraic dynamics algorithm can better preserve both geometrical and dynamical fidelity of a dynamical system at a controllable precision, and it can solve the problem of algorithm-induced dissipation for the Runge-Kutta algorithm and the problem of algorithm-induced phase shift for the symplectic geometric algorithm.

  19. Symplectic integrators for large scale molecular dynamics simulations: A comparison of several explicit methods

    International Nuclear Information System (INIS)

    Gray, S.K.; Noid, D.W.; Sumpter, B.G.

    1994-01-01

    We test the suitability of a variety of explicit symplectic integrators for molecular dynamics calculations on Hamiltonian systems. These integrators are extremely simple algorithms with low memory requirements, and appear to be well suited for large scale simulations. We first apply all the methods to a simple test case using the ideas of Berendsen and van Gunsteren. We then use the integrators to generate long time trajectories of a 1000 unit polyethylene chain. Calculations are also performed with two popular but nonsymplectic integrators. The most efficient integrators of the set investigated are deduced. We also discuss certain variations on the basic symplectic integration technique

  20. A differential algebraic integration algorithm for symplectic mappings in systems with three-dimensional magnetic field

    International Nuclear Information System (INIS)

    Chang, P.; Lee, S.Y.; Yan, Y.T.

    2006-01-01

    A differential algebraic integration algorithm is developed for symplectic mapping through a three-dimensional (3-D) magnetic field. The self-consistent reference orbit in phase space is obtained by making a canonical transformation to eliminate the linear part of the Hamiltonian. Transfer maps from the entrance to the exit of any 3-D magnetic field are then obtained through slice-by-slice symplectic integration. The particle phase-space coordinates are advanced by using the integrable polynomial procedure. This algorithm is a powerful tool to attain nonlinear maps for insertion devices in synchrotron light source or complicated magnetic field in the interaction region in high energy colliders

  1. Canonical symplectic structure and structure-preserving geometric algorithms for Schrödinger-Maxwell systems

    Science.gov (United States)

    Chen, Qiang; Qin, Hong; Liu, Jian; Xiao, Jianyuan; Zhang, Ruili; He, Yang; Wang, Yulei

    2017-11-01

    An infinite dimensional canonical symplectic structure and structure-preserving geometric algorithms are developed for the photon-matter interactions described by the Schrödinger-Maxwell equations. The algorithms preserve the symplectic structure of the system and the unitary nature of the wavefunctions, and bound the energy error of the simulation for all time-steps. This new numerical capability enables us to carry out first-principle based simulation study of important photon-matter interactions, such as the high harmonic generation and stabilization of ionization, with long-term accuracy and fidelity.

  2. A Differential Algebraic Integration Algorithm for Symplectic Mappings in Systems with Three-Dimensional Magnetic Field

    International Nuclear Information System (INIS)

    Chang, P

    2004-01-01

    A differential algebraic integration algorithm is developed for symplectic mapping through a three-dimensional (3-D) magnetic field. The self-consistent reference orbit in phase space is obtained by making a canonical transformation to eliminate the linear part of the Hamiltonian. Transfer maps from the entrance to the exit of any 3-D magnetic field are then obtained through slice-by-slice symplectic integration. The particle phase-space coordinates are advanced by using the integrable polynomial procedure. This algorithm is a powerful tool to attain nonlinear maps for insertion devices in synchrotron light source or complicated magnetic field in the interaction region in high energy colliders

  3. Pharmacokinetics, safety, and tolerability of varenicline in healthy adolescent smokers: a multicenter, randomized, double-blind, placebo-controlled, parallel-group study.

    Science.gov (United States)

    Faessel, Helene; Ravva, Patanjali; Williams, Kathryn

    2009-01-01

    Varenicline is approved as an aid to smoking cessation in adults aged > or =18 years. The goal of this study was to characterize the multiple-dose pharmacokinetics, safety, and tolerability of varenicline in adolescent smokers. This multicenter, randomized, double-blind, placebo-controlled, parallel-group study enrolled healthy 12- to 16-year-old smokers (> or =3 cigarettes daily) into high-body-weight (>55 kg) and low-body-weight (daily. The apparent renal clearance (CL/F) and volume of distribution (V/F) of varenicline and the effect of body weight on these parameters were estimated using nonlinear mixed-effects modeling. The high-body-weight group consisted of 35 subjects (65.7% male; 77.1% white; mean age, 15.2 years). The low-body-weight group consisted of 37 subjects (37.8% male; 48.6% white; mean age, 14.3 years). The pharmacokinetic parameters of varenicline were dose proportional over the dose range from 0.5 to 2 mg/d. The CL/F for a 70-kg adolescent was 10.4 L/h, comparable to that in a 70-kg adult. The estimated varenicline V/F was decreased in individuals of small body size, thus predicting a varenicline C(max) approximately 30% greater in low-body-weight subjects than in high-body-weight subjects. In high-body-weight subjects, steady-state varenicline exposure, as represented by the AUC(0-24), was 197.0 ng . h/mL for varenicline 1 mg BID and 95.7 ng . h/mL for varenicline 0.5 mg BID, consistent with values reported previously in adult smokers at the equivalent doses. In low-body-weight subjects, varenicline exposure was 126.3 ng . h/mL for varenicline 0.5 mg BID and 60.1 ng . h/mL for varenicline 0.5 mg once daily, values at the lower end of the range observed previously in adults at doses of 1 mg BID and 0.5 mg BID, respectively. Among high-body-weight subjects, adverse events (AEs) were reported by 57.1% of subjects in both the high- and low-dose varenicline groups and by 14.3% of subjects in the placebo group; among low-body-weight subjects, AEs

  4. Exact smooth classification of Hamiltonian vector fields on symplectic 2-manifolds

    International Nuclear Information System (INIS)

    Krouglikov, B.S.

    1994-10-01

    Complete exact classification of Hamiltonian systems with one degree of freedom and Morse Hamiltonian is carried out. As it is a main part of trajectory classification of integrable Hamiltonian systems with two degrees of freedom, the corresponding generalization is considered. The dual problem of classification of symplectic form together with Morse foliation is carried out as well. (author). 10 refs, 16 figs

  5. Some New Constructions of Authentication Codes with Arbitration and Multi-Receiver from Singular Symplectic Geometry

    Directory of Open Access Journals (Sweden)

    You Gao

    2011-01-01

    Full Text Available A new construction of authentication codes with arbitration and multireceiver from singular symplectic geometry over finite fields is given. The parameters are computed. Assuming that the encoding rules are chosen according to a uniform probability distribution, the probabilities of success for different types of deception are also computed.

  6. Symplectic homoclinic tangles of the ideal separatrix of the DIII-D from type I ELMs

    Science.gov (United States)

    Punjabi, Alkesh; Ali, Halima

    2012-10-01

    The ideal separatrix of the divertor tokamaks is a degenerate manifold where both the stable and unstable manifolds coincide. Non-axisymmetric magnetic perturbations remove the degeneracy; and split the separatrix manifold. This creates an extremely complex topological structure, called homoclinic tangles. The unstable manifold intersects the stable manifold and creates alternating inner and outer lobes at successive homoclinic points. The Hamiltonian system must preserve the symplectic topological invariance, and this controls the size and radial extent of the lobes. Very recently, lobes near the X-point have been experimentally observed in MAST [A. Kirk et al, PRL 108, 255003 (2012)]. We have used the DIII-D map [A. Punjabi, NF 49, 115020 (2009)] to calculate symplectic homoclinic tangles of the ideal separatrix of the DIII-D from the type I ELMs represented by the peeling-ballooning modes (m,n)=(30,10)+(40,10). The DIII-D map is symplectic, accurate, and is in natural canonical coordinates which are invertible to physical coordinates [A. Punjabi and H. Ali, POP 15, 122502 (2008)]. To our knowledge, we are the first to symplectically calculate these tangles in physical space. Homoclinic tangles of separatrix can cause radial displacement of mobile passing electrons and create sheared radial electric fields and currents, resulting in radial flows, drifts, differential spinning, and reduction in turbulence, and other effects. This work is supported by the grants DE-FG02-01ER54624 and DE-FG02-04ER54793.

  7. Hamiltonian dynamics on the symplectic extended phase space for autonomous and non-autonomous systems

    International Nuclear Information System (INIS)

    Struckmeier, Juergen

    2005-01-01

    We will present a consistent description of Hamiltonian dynamics on the 'symplectic extended phase space' that is analogous to that of a time-independent Hamiltonian system on the conventional symplectic phase space. The extended Hamiltonian H 1 and the pertaining extended symplectic structure that establish the proper canonical extension of a conventional Hamiltonian H will be derived from a generalized formulation of Hamilton's variational principle. The extended canonical transformation theory then naturally permits transformations that also map the time scales of the original and destination system, while preserving the extended Hamiltonian H 1 , and hence the form of the canonical equations derived from H 1 . The Lorentz transformation, as well as time scaling transformations in celestial mechanics, will be shown to represent particular canonical transformations in the symplectic extended phase space. Furthermore, the generalized canonical transformation approach allows us to directly map explicitly time-dependent Hamiltonians into time-independent ones. An 'extended' generating function that defines transformations of this kind will be presented for the time-dependent damped harmonic oscillator and for a general class of explicitly time-dependent potentials. In the appendix, we will re-establish the proper form of the extended Hamiltonian H 1 by means of a Legendre transformation of the extended Lagrangian L 1

  8. Principal and nonprincipal solutions of symplectic dynamic systems on time scales

    Directory of Open Access Journals (Sweden)

    Ondrej Dosly

    2000-01-01

    Full Text Available We establish the concept of the principal and nonprincipal solution for the so-called symplectic dynamic systems on time scales. We also present a brief survey of the history of these concept for differential and difference equations.

  9. Classification of the linear canonical transformation and its associated real symplectic matrix

    NARCIS (Netherlands)

    Bastiaans, M.J.; Alieva, T.

    2007-01-01

    Based on the eigenvalues of the real symplectic ABCD-matrix that characterizes the linear canonical integral transformation, a classification of this transformation and the associated ABCD-system is proposed and some nuclei (i.e. elementary members) in each class are described. In the

  10. The Monge-Ampère equation: Hamiltonian and symplectic structures, recursions, and hierarchies

    NARCIS (Netherlands)

    Kersten, P.H.M.; Krasil'shchik, I.; Verbovetsky, A.V.

    2004-01-01

    Using methods of geometry and cohomology developed recently, we study the Monge-Ampère equation, arising as the first nontrivial equation in the associativity equations, or WDVV equations. We describe Hamiltonian and symplectic structures as well as recursion operators for this equation in its

  11. An optimized formulation for Deprit-type Lie transformations of Taylor maps for symplectic systems

    International Nuclear Information System (INIS)

    Shi, Jicong

    1993-01-01

    An optimized iterative formulation is presented for directly transforming a Taylor map of a symplectic system into a Deprit-type Lie transformation, which is a composition of a linear transfer matrix and a single Lie transformation, to an arbitrary order

  12. From symplectic integrator to Poincare map: Spline expansion of a map generator in Cartesian coordinates

    International Nuclear Information System (INIS)

    Warnock, R.L.; Ellison, J.A.; Univ. of New Mexico, Albuquerque, NM

    1997-08-01

    Data from orbits of a symplectic integrator can be interpolated so as to construct an approximation to the generating function of a Poincare map. The time required to compute an orbit of the symplectic map induced by the generator can be much less than the time to follow the same orbit by symplectic integration. The construction has been carried out previously for full-turn maps of large particle accelerators, and a big saving in time (for instance a factor of 60) has been demonstrated. A shortcoming of the work to date arose from the use of canonical polar coordinates, which precluded map construction in small regions of phase space near coordinate singularities. This paper shows that Cartesian coordinates can also be used, thus avoiding singularities. The generator is represented in a basis of tensor product B-splines. Under weak conditions the spline expansion converges uniformly as the mesh is refined, approaching the exact generator of the Poincare map as defined by the symplectic integrator, in some parallelepiped of phase space centered at the origin

  13. Effects of policosanol on borderline to mildly elevated serum total cholesterol levels: a prospective, double-blind, placebo-controlled, parallel-group, comparative study

    Directory of Open Access Journals (Sweden)

    Gladys Castaño, PhD

    2003-09-01

    Full Text Available Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Clinical studies have shown that lowering elevated serum cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C, is beneficial for patients with borderline to mildly elevated serum total cholesterol (TC levels (5.0–6.0 mmol/L. Policosanol is a cholesterol-lowering drug made from purified sugar cane wax. The therapeutic range of policosanol is 5 to 20 mg/d. Objective: This study investigated the efficacy and tolerability of policosanol 5 mg/d in patients with borderline to mildly elevated serum TC levels. Methods: This 14-week, single-center, prospective, double-blind, placebo-controlled, parallel-group, comparative study was conducted in men and women aged 25 to 75 years with a serum TC level ≥4.8 to <6.0 mmol/L. After a 6-week run-in period in which patients were placed on therapeutic lifestyle changes, in particular a cholesterol-lowering diet, patients were randomly assigned to receive policosanol 5-mg tablets or placebo tablets once daily with the evening meal for 8 weeks, and the diet was continued throughout the study. Lipid profile variables, safety indicators, adverse events (AEs, and compliance with study medications were assessed. Results: One hundred patients (71 women, 29 men; mean [SD] age, 52 [10] years entered the study after the dietary run-in period. After 8 weeks of treatment, the mean (SD serum LDL-C level decreased significantly in the policosanol group (P<0.001 vs baseline and placebo from 3.57 (0.30 mmol/L to 2.86 (0.41 mmol/L (change, −19.9%. Significantly more patients in the policosanol group (42 patients [84%] achieved a ≥15% decrease in serum LDL-C than in the placebo group (2 patients [4%] (P<0.001. Also in the policosanol group, the mean (SD serum TC level decreased significantly, from 5.20 (0.22 mmol/L to 4.56 (0.44 mmol/L (P<0.001 vs baseline and placebo (change, −12.3%; the mean (SD triglyceride (TG

  14. Explicit symplectic algorithms based on generating functions for relativistic charged particle dynamics in time-dependent electromagnetic field

    Science.gov (United States)

    Zhang, Ruili; Wang, Yulei; He, Yang; Xiao, Jianyuan; Liu, Jian; Qin, Hong; Tang, Yifa

    2018-02-01

    Relativistic dynamics of a charged particle in time-dependent electromagnetic fields has theoretical significance and a wide range of applications. The numerical simulation of relativistic dynamics is often multi-scale and requires accurate long-term numerical simulations. Therefore, explicit symplectic algorithms are much more preferable than non-symplectic methods and implicit symplectic algorithms. In this paper, we employ the proper time and express the Hamiltonian as the sum of exactly solvable terms and product-separable terms in space-time coordinates. Then, we give the explicit symplectic algorithms based on the generating functions of orders 2 and 3 for relativistic dynamics of a charged particle. The methodology is not new, which has been applied to non-relativistic dynamics of charged particles, but the algorithm for relativistic dynamics has much significance in practical simulations, such as the secular simulation of runaway electrons in tokamaks.

  15. Orthogonal and symplectic Yangians and Yang–Baxter R-operators

    International Nuclear Information System (INIS)

    Isaev, A.P.; Karakhanyan, D.; Kirschner, R.

    2016-01-01

    Yang–Baxter R operators symmetric with respect to the orthogonal and symplectic algebras are considered in an uniform way. Explicit forms for the spinorial and metaplectic R operators are obtained. L operators, obeying the RLL relation with the orthogonal or symplectic fundamental R matrix, are considered in the interesting cases, where their expansion in inverse powers of the spectral parameter is truncated. Unlike the case of special linear algebra symmetry the truncation results in additional conditions on the Lie algebra generators of which the L operators is built and which can be fulfilled in distinguished representations only. Further, generalized L operators, obeying the modified RLL relation with the fundamental R matrix replaced by the spinorial or metaplectic one, are considered in the particular case of linear dependence on the spectral parameter. It is shown how by fusion with respect to the spinorial or metaplectic representation these first order spinorial L operators reproduce the ordinary L operators with second order truncation.

  16. Orthogonal and symplectic Yangians and Yang–Baxter R-operators

    Energy Technology Data Exchange (ETDEWEB)

    Isaev, A.P., E-mail: isaevap@theor.jinr.ru [Bogoliubov Lab., Joint Institute of Nuclear Research, Dubna (Russian Federation); Karakhanyan, D., E-mail: karakhan@yerphi.am [Yerevan Physics Institute, 2 Alikhanyan br., 0036 Yerevan (Armenia); Kirschner, R., E-mail: Roland.Kirschner@itp.uni-leipzig.de [Institut für Theoretische Physik, Universität Leipzig, PF 100 920, D-04009 Leipzig (Germany)

    2016-03-15

    Yang–Baxter R operators symmetric with respect to the orthogonal and symplectic algebras are considered in an uniform way. Explicit forms for the spinorial and metaplectic R operators are obtained. L operators, obeying the RLL relation with the orthogonal or symplectic fundamental R matrix, are considered in the interesting cases, where their expansion in inverse powers of the spectral parameter is truncated. Unlike the case of special linear algebra symmetry the truncation results in additional conditions on the Lie algebra generators of which the L operators is built and which can be fulfilled in distinguished representations only. Further, generalized L operators, obeying the modified RLL relation with the fundamental R matrix replaced by the spinorial or metaplectic one, are considered in the particular case of linear dependence on the spectral parameter. It is shown how by fusion with respect to the spinorial or metaplectic representation these first order spinorial L operators reproduce the ordinary L operators with second order truncation.

  17. On the Faddeev-Jackiw symplectic framework for topologically massive gravity

    Energy Technology Data Exchange (ETDEWEB)

    Escalante, Alberto [Benemerita Universidad Autonoma de Puebla, Instituto de Fisica, Puebla (Mexico); Rodriguez-Tzompantzi, Omar [Benemerita Universidad Autonoma de Puebla, Facultad de Ciencias Fisico Matematicas, Puebla (Mexico)

    2016-10-15

    The dynamical structure of topologically massive gravity in the context of the Faddeev-Jackiw symplectic approach is studied. It is shown that this method allows us to avoid some ambiguities arising in the study of the gauge structure via the Dirac formalism. In particular, the complete set of constraints and the generators of the gauge symmetry of the theory are obtained straightforwardly via the zero modes of the symplectic matrix. In order to obtain the generalized Faddeev-Jackiw brackets and calculate the local physical degrees of freedom of this model, an appropriate gauge-fixing procedure is introduced. Finally, the similarities and relative advantages between the Faddeev-Jackiw method and Dirac's formalism are briefly discussed. (orig.)

  18. Wavelet approach to accelerator problems. 3: Melnikov functions and symplectic topology

    International Nuclear Information System (INIS)

    Fedorova, A.; Zeitlin, M.; Parsa, Z.

    1997-05-01

    This is the third part of a series of talks in which the authors present applications of methods of wavelet analysis to polynomial approximations for a number of accelerator physics problems. They consider the generalization of the variational wavelet approach to nonlinear polynomial problems to the case of Hamiltonian systems for which they need to preserve underlying symplectic or Poissonian or quasicomplex structures in any type of calculations. They use the approach for the problem of explicit calculations of Arnold-Weinstein curves via Floer variational approach from symplectic topology. The loop solutions are parameterized by the solutions of reduced algebraical problem--matrix Quadratic Mirror Filters equations. Also they consider wavelet approach to the calculations of Melnikov functions in the theory of homoclinic chaos in perturbed Hamiltonian systems

  19. Symplectic Tracking of Multi-Isotopic Heavy-Ion Beams in SixTrack

    CERN Document Server

    Hermes, Pascal; De Maria, Riccardo

    2016-01-01

    The software SixTrack provides symplectic proton tracking over a large number of turns. The code is used for the tracking of beam halo particles and the simulation of their interaction with the collimators to study the efficiency of the LHC collimation system. Tracking simulations for heavy-ion beams require taking into account the mass to charge ratio of each particle because heavy ions can be subject to fragmentation at their passage through the collimators. In this paper we present the derivation of a Hamiltonian for multi-isotopic heavy-ion beams and symplectic tracking maps derived from it. The resulting tracking maps were implemented in the tracking software SixTrack. With this modification, SixTrack can be used to natively track heavy-ion beams of multiple isotopes through a magnetic accelerator lattice.

  20. Application of the symplectic finite-difference time-domain scheme to electromagnetic simulation

    International Nuclear Information System (INIS)

    Sha, Wei; Huang, Zhixiang; Wu, Xianliang; Chen, Mingsheng

    2007-01-01

    An explicit fourth-order finite-difference time-domain (FDTD) scheme using the symplectic integrator is applied to electromagnetic simulation. A feasible numerical implementation of the symplectic FDTD (SFDTD) scheme is specified. In particular, new strategies for the air-dielectric interface treatment and the near-to-far-field (NFF) transformation are presented. By using the SFDTD scheme, both the radiation and the scattering of three-dimensional objects are computed. Furthermore, the energy-conserving characteristic hold for the SFDTD scheme is verified under long-term simulation. Numerical results suggest that the SFDTD scheme is more efficient than the traditional FDTD method and other high-order methods, and can save computational resources

  1. An A Posteriori Error Estimate for Symplectic Euler Approximation of Optimal Control Problems

    KAUST Repository

    Karlsson, Peer Jesper

    2015-01-07

    This work focuses on numerical solutions of optimal control problems. A time discretization error representation is derived for the approximation of the associated value function. It concerns Symplectic Euler solutions of the Hamiltonian system connected with the optimal control problem. The error representation has a leading order term consisting of an error density that is computable from Symplectic Euler solutions. Under an assumption of the pathwise convergence of the approximate dual function as the maximum time step goes to zero, we prove that the remainder is of higher order than the leading error density part in the error representation. With the error representation, it is possible to perform adaptive time stepping. We apply an adaptive algorithm originally developed for ordinary differential equations.

  2. An Error Estimate for Symplectic Euler Approximation of Optimal Control Problems

    KAUST Repository

    Karlsson, Jesper; Larsson, Stig; Sandberg, Mattias; Szepessy, Anders; Tempone, Raul

    2015-01-01

    This work focuses on numerical solutions of optimal control problems. A time discretization error representation is derived for the approximation of the associated value function. It concerns symplectic Euler solutions of the Hamiltonian system connected with the optimal control problem. The error representation has a leading-order term consisting of an error density that is computable from symplectic Euler solutions. Under an assumption of the pathwise convergence of the approximate dual function as the maximum time step goes to zero, we prove that the remainder is of higher order than the leading-error density part in the error representation. With the error representation, it is possible to perform adaptive time stepping. We apply an adaptive algorithm originally developed for ordinary differential equations. The performance is illustrated by numerical tests.

  3. Multi-symplectic Runge-Kutta methods for nonlinear Dirac equations

    International Nuclear Information System (INIS)

    Hong Jialin; Li Chun

    2006-01-01

    In this paper, we consider the multi-symplectic Runge-Kutta (MSRK) methods applied to the nonlinear Dirac equation in relativistic quantum physics, based on a discovery of the multi-symplecticity of the equation. In particular, the conservation of energy, momentum and charge under MSRK discretizations is investigated by means of numerical experiments and numerical comparisons with non-MSRK methods. Numerical experiments presented reveal that MSRK methods applied to the nonlinear Dirac equation preserve exactly conservation laws of charge and momentum, and conserve the energy conservation in the corresponding numerical accuracy to the method utilized. It is verified numerically that MSRK methods are stable and convergent with respect to the conservation laws of energy, momentum and charge, and MSRK methods preserve not only the inner geometric structure of the equation, but also some crucial conservative properties in quantum physics. A remarkable advantage of MSRK methods applied to the nonlinear Dirac equation is the precise preservation of charge conservation law

  4. Symplectic geometry on moduli spaces of holomorphic bundles over complex surfaces

    OpenAIRE

    Khesin, Boris; Rosly, Alexei

    2000-01-01

    We give a comparative description of the Poisson structures on the moduli spaces of flat connections on real surfaces and holomorphic Poisson structures on the moduli spaces of holomorphic bundles on complex surfaces. The symplectic leaves of the latter are classified by restrictions of the bundles to certain divisors. This can be regarded as fixing a "complex analogue of the holonomy" of a connection along a "complex analogue of the boundary" in analogy with the real case.

  5. Path integral quantization of the Symplectic Leaves of the SU(2)*Poisson-Lie Group

    International Nuclear Information System (INIS)

    Morariu, B.

    1997-01-01

    The Feynman path integral is used to quantize the symplectic leaves of the Poisson-Lie group SU(2)*. In this way we obtain the unitary representations of Uq(su(2)). This is achieved by finding explicit Darboux coordinates and then using a phase space path integral. I discuss the *-structure of SU(2)* and give a detailed description of its leaves using various parameterizations and also compare the results with the path integral quantization of spin

  6. Construction and uniqueness of the C*-Weyl algebra over a general pre-symplectic space

    International Nuclear Information System (INIS)

    Binz, Ernst; Honegger, Reinhard; Rieckers, Alfred

    2004-01-01

    A systematic approach to the C*-Weyl algebra W(E,σ) over a possibly degenerate pre-symplectic form σ on a real vector space E of possibly infinite dimension is elaborated in an almost self-contained manner. The construction is based on the theory of Kolmogorov decompositions for σ-positive-definite functions on involutive semigroups and their associated projective unitary group representations. The σ-positive-definite functions provide also the C*-norm of W(E,σ), the latter being shown to be *-isomorphic to the twisted group C*-algebra of the discrete vector group E. The connections to related constructions are indicated. The treatment of the fundamental symmetries is outlined for arbitrary pre-symplectic σ. The construction method is especially applied to the trivial symplectic form σ=0, leading to the commutative Weyl algebra over E, which is shown to be isomorphic to the C*-algebra of the almost periodic continuous function on the topological dual E τ ' of E with respect to an arbitrary locally convex Hausdorff topology τ on E. It is demonstrated that the almost periodic compactification aE τ ' of E τ ' is independent of the chosen locally convex τ on E, and that aE τ ' is continuously group isomorphic to the character group E of E. Applications of the results to the procedures of strict and continuous deformation quantizations are mentioned in the outlook

  7. Two modified symplectic partitioned Runge-Kutta methods for solving the elastic wave equation

    Science.gov (United States)

    Su, Bo; Tuo, Xianguo; Xu, Ling

    2017-08-01

    Based on a modified strategy, two modified symplectic partitioned Runge-Kutta (PRK) methods are proposed for the temporal discretization of the elastic wave equation. The two symplectic schemes are similar in form but are different in nature. After the spatial discretization of the elastic wave equation, the ordinary Hamiltonian formulation for the elastic wave equation is presented. The PRK scheme is then applied for time integration. An additional term associated with spatial discretization is inserted into the different stages of the PRK scheme. Theoretical analyses are conducted to evaluate the numerical dispersion and stability of the two novel PRK methods. A finite difference method is used to approximate the spatial derivatives since the two schemes are independent of the spatial discretization technique used. The numerical solutions computed by the two new schemes are compared with those computed by a conventional symplectic PRK. The numerical results, which verify the new method, are superior to those generated by traditional conventional methods in seismic wave modeling.

  8. Symplectic tracking using point magnets in the presence of a longitudinal magnetic field

    International Nuclear Information System (INIS)

    Parzen, G.

    1993-09-01

    In the absence of a longitudinal magnetic field, symplectic tracking can be achieved by replacing the magnets by a series of point magnets and drift spaces. To treat the case when a longitudinal magnetic field is also present, this procedure is modified in this paper by replacing the drift space by a solenoidal drift, which is defined as the motion of a particle in a uniform longitudinal magnetic field. A symplectic integrator can be obtained by subdividing each magnet into pieces and replacing each magnet piece by point magnets, with only transverse fields, and solenoidal drift spaces. The reference orbit used here is made up of arcs of circles and straight lines which join smoothly with each other. For this choice of reference orbit, the required results are obtained to track particles, which are the transfer functions, and the transfer time for the different elements. It is shown that these results provide a symplectic integrator, and they are exact in the sense that as the number of magnet pieces is increased, the particle motion will converge to the particle motion of the exact equations of motion

  9. Investigation and performance tests of a new parallel plate ionization chamber with double sensitive volume for measuring diagnostic X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Sharifi, B., E-mail: babak_sharifi88@yahoo.com [Graduate University of Advanced Technology, Kerman (Iran, Islamic Republic of); Zamani Zeinali, H. [Application of Radiation Research School, Nuclear Science and Technology Research Institute, AEOI, Karaj (Iran, Islamic Republic of); Soltani, J.; Negarestani, A. [Graduate University of Advanced Technology, Kerman (Iran, Islamic Republic of); Shahvar, A. [Application of Radiation Research School, Nuclear Science and Technology Research Institute, AEOI, Karaj (Iran, Islamic Republic of)

    2015-01-11

    Medical diagnostic equipment, like diagnostic radiology and mammography require a dosimeter with high accuracy for dosimetry of the diagnostic X-ray beam. Ionization chambers are suitable instruments for dosimetry of diagnostic-range X-ray beams because of their appropriate response and high reliability. This work introduces the design and fabrication of a new parallel plate ionization chamber with a PMMA body, graphite-coated PMMA windows (0.5 mm thick) and a graphite-foil central electrode (0.1 mm thick, 0.7 g/cm{sup 3} dense). This design improves upon the response characteristics of existing designs through the specific choice of materials as well as the appropriate size and arrangement of the ionization chamber components. The results of performance tests conducted at the Secondary Standard Dosimetry laboratory in Karaj-Iran demonstrated the short and long-term stability, the low leakage current, the low directional dependence, and the high ion collection efficiency of the design. Furthermore, the FLUKA Monte Carlo simulations confirmed the low effect of central electrode on this new ionization chamber response. The response characteristics of the parallel plate ionization chamber presented in this work makes the instrument suitable for use as a standard dosimeter in laboratories.

  10. Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study.

    Science.gov (United States)

    Tsutsui, Hiroyuki; Momomura, Shinichi; Saito, Yoshihiko; Ito, Hiroshi; Yamamoto, Kazuhiro; Ohishi, Tomomi; Okino, Naoko; Guo, Weinong

    2017-09-01

    The prognosis of heart failure patients with reduced ejection fraction (HFrEF) in Japan remains poor, although there is growing evidence for increasing use of evidence-based pharmacotherapies in Japanese real-world HF registries. Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor shown to reduce mortality and morbidity in the recently completed largest outcome trial in patients with HFrEF (PARADIGM-HF trial). The prospectively designed phase III PARALLEL-HF (Prospective comparison of ARNI with ACE inhibitor to determine the noveL beneficiaL trEatment vaLue in Japanese Heart Failure patients) study aims to assess the clinical efficacy and safety of LCZ696 in Japanese HFrEF patients, and show similar improvements in clinical outcomes as the PARADIGM-HF study enabling the registration of LCZ696 in Japan. This is a multicenter, randomized, double-blind, parallel-group, active controlled study of 220 Japanese HFrEF patients. Eligibility criteria include a diagnosis of chronic HF (New York Heart Association Class II-IV) and reduced ejection fraction (left ventricular ejection fraction ≤35%) and increased plasma concentrations of natriuretic peptides [N-terminal pro B-type natriuretic peptide (NT-proBNP) ≥600pg/mL, or NT-proBNP ≥400pg/mL for those who had a hospitalization for HF within the last 12 months] at the screening visit. The study consists of three phases: (i) screening, (ii) single-blind active LCZ696 run-in, and (iii) double-blind randomized treatment. Patients tolerating LCZ696 50mg bid during the treatment run-in are randomized (1:1) to receive LCZ696 100mg bid or enalapril 5mg bid for 4 weeks followed by up-titration to target doses of LCZ696 200mg bid or enalapril 10mg bid in a double-blind manner. The primary outcome is the composite of cardiovascular death or HF hospitalization and the study is an event-driven trial. The design of the PARALLEL-HF study is aligned with the PARADIGM-HF study and aims to assess

  11. Parallel rendering

    Science.gov (United States)

    Crockett, Thomas W.

    1995-01-01

    This article provides a broad introduction to the subject of parallel rendering, encompassing both hardware and software systems. The focus is on the underlying concepts and the issues which arise in the design of parallel rendering algorithms and systems. We examine the different types of parallelism and how they can be applied in rendering applications. Concepts from parallel computing, such as data decomposition, task granularity, scalability, and load balancing, are considered in relation to the rendering problem. We also explore concepts from computer graphics, such as coherence and projection, which have a significant impact on the structure of parallel rendering algorithms. Our survey covers a number of practical considerations as well, including the choice of architectural platform, communication and memory requirements, and the problem of image assembly and display. We illustrate the discussion with numerous examples from the parallel rendering literature, representing most of the principal rendering methods currently used in computer graphics.

  12. Multicenter, double-blind, parallel group study investigating the non-inferiority of efficacy and safety of a 2% miconazole nitrate shampoo in comparison with a 2% ketoconazole shampoo in the treatment of seborrhoeic dermatitis of the scalp.

    Science.gov (United States)

    Buechner, Stanislaw A

    2014-06-01

    This study investigated the non-inferiority of efficacy and tolerance of 2% miconazole nitrate shampoo in comparison with 2% ketoconazole shampoo in the treatment of scalp seborrheic dermatitis. A randomized, double-blind, comparative, parallel group, multicenter study was done. A total of 274 patients (145 miconazole, 129 ketoconazole) were enrolled. Treatment was twice-weekly for 4 weeks. Safety and efficacy assessments were made at baseline and at weeks 2 and 4. Assessments included symptoms of erythema, itching, scaling ['Symptom Scale of Seborrhoeic Dermatitis' (SSSD)], disease severity and global change [Clinical Global Impressions (CGIs) and Patient Global Impressions (PGIs)]. Miconazole shampoo is at least as effective and safe as ketoconazole shampoo in treating scalp seborrheic dermatitis scalp.

  13. Parallel computations

    CERN Document Server

    1982-01-01

    Parallel Computations focuses on parallel computation, with emphasis on algorithms used in a variety of numerical and physical applications and for many different types of parallel computers. Topics covered range from vectorization of fast Fourier transforms (FFTs) and of the incomplete Cholesky conjugate gradient (ICCG) algorithm on the Cray-1 to calculation of table lookups and piecewise functions. Single tridiagonal linear systems and vectorized computation of reactive flow are also discussed.Comprised of 13 chapters, this volume begins by classifying parallel computers and describing techn

  14. Pyrrolo-dC Metal-Mediated Base Pairs in the Reverse Watson-Crick Double Helix: Enhanced Stability of Parallel DNA and Impact of 6-Pyridinyl Residues on Fluorescence and Silver-Ion Binding.

    Science.gov (United States)

    Yang, Haozhe; Mei, Hui; Seela, Frank

    2015-07-06

    Reverse Watson-Crick DNA with parallel-strand orientation (ps DNA) has been constructed. Pyrrolo-dC (PyrdC) nucleosides with phenyl and pyridinyl residues linked to the 6 position of the pyrrolo[2,3-d]pyrimidine base have been incorporated in 12- and 25-mer oligonucleotide duplexes and utilized as silver-ion binding sites. Thermal-stability studies on the parallel DNA strands demonstrated extremely strong silver-ion binding and strongly enhanced duplex stability. Stoichiometric UV and fluorescence titration experiments verified that a single (2py) PyrdC-(2py) PyrdC pair captures two silver ions in ps DNA. A structure for the PyrdC silver-ion base pair that aligns 7-deazapurine bases head-to-tail instead of head-to-head, as suggested for canonical DNA, is proposed. The silver DNA double helix represents the first example of a ps DNA structure built up of bidentate and tridentate reverse Watson-Crick base pairs stabilized by a dinuclear silver-mediated PyrdC pair. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Moduli of double EPW-sextics

    CERN Document Server

    O'Grady, Kieran G

    2016-01-01

    The author studies the GIT quotient of the symplectic grassmannian parametrizing lagrangian subspaces of \\bigwedge^3{\\mathbb C}^6 modulo the natural action of \\mathrm{SL}_6, call it \\mathfrak{M}. This is a compactification of the moduli space of smooth double EPW-sextics and hence birational to the moduli space of HK 4-folds of Type K3^{[2]} polarized by a divisor of square 2 for the Beauville-Bogomolov quadratic form. The author will determine the stable points. His work bears a strong analogy with the work of Voisin, Laza and Looijenga on moduli and periods of cubic 4-folds.

  16. Exact vibration analysis of a double-nanobeam-systems embedded in an elastic medium by a Hamiltonian-based method

    Science.gov (United States)

    Zhou, Zhenhuan; Li, Yuejie; Fan, Junhai; Rong, Dalun; Sui, Guohao; Xu, Chenghui

    2018-05-01

    A new Hamiltonian-based approach is presented for finding exact solutions for transverse vibrations of double-nanobeam-systems embedded in an elastic medium. The continuum model is established within the frameworks of the symplectic methodology and the nonlocal Euler-Bernoulli and Timoshenko beam beams. The symplectic eigenfunctions are obtained after expressing the governing equations in a Hamiltonian form. Exact frequency equations, vibration modes and displacement amplitudes are obtained by using symplectic eigenfunctions and end conditions. Comparisons with previously published work are presented to illustrate the accuracy and reliability of the proposed method. The comprehensive results for arbitrary boundary conditions could serve as benchmark results for verifying numerically obtained solutions. In addition, a study on the difference between the nonlocal beam and the nonlocal plate is also included.

  17. The efficacy and safety of fixed-dose combination of amlodipine/benazepril in Chinese essential hypertensive patients not adequately controlled with benazepril monotherapy: a multicenter, randomized, double-blind, double-dummy, parallel-group clinical trial.

    Science.gov (United States)

    Yan, Pingping; Fan, Weihu

    2014-01-01

    This double-blind, double-dummy clinical trial evaluated the efficacy and safety of two strengths of fixed-dose combination of amlodipine/benazepril in Chinese hypertensive patients not adequately controlled with benazepril. Of 442 patients who received treatment with benazepril 10 mg for 4 weeks, 341 patients failed to achieve to diastolic blood pressure (DBP) benazepril 2.5/10 mg, or amlodipine/benazepril 5/10 mg, or benazepril 10 mg for 8 weeks. BP reductions with amodipinel/benazepril 2.5/10 mg (15.2/11.8 mmHg) or amlodipine/benazepril 5/10 mg (15.4/12.4 mmHg) were significantly greater than that with benazepril 10 mg (9.88/9.46 mmHg) at study end (p benazepril). BP control rate was 83.8% with amlodipine/benazepril 2.5/10 mg, 80.2% with amlodipine/benazepril 5/10 mg, 64.9% with benazepril 10 mg at study end (p benazepril). Three groups were generally well tolerated. Our study indicated that amlodipine/benazepril fixed-dose combination offered significant additional BP reductions and BP control rate compared with the continuation of benazepril monotherapy. No significant differences were observed in both BP reductions and BP control rate between amlodipine/benazepril 2.5/10 mg and amlodipine/benazepril 5/10 mg.

  18. Impact of Skill-Based Approaches in Reducing Stigma in Primary Care Physicians: Results from a Double-Blind, Parallel-Cluster, Randomized Controlled Trial.

    Science.gov (United States)

    Beaulieu, Tara; Patten, Scott; Knaak, Stephanie; Weinerman, Rivian; Campbell, Helen; Lauria-Horner, Bianca

    2017-05-01

    Most interventions to reduce stigma in health professionals emphasize education and social contact-based strategies. We sought to evaluate a novel skill-based approach: the British Columbia Adult Mental Health Practice Support Program. We sought to determine the program's impact on primary care providers' stigma and their perceived confidence and comfort in providing care for mentally ill patients. We hypothesized that enhanced skills and increased comfort and confidence on the part of practitioners would lead to diminished social distance and stigmatization. Subsequently, we explored the program's impact on clinical outcomes and health care costs. These outcomes are reported separately, with reference to this article. In a double-blind, cluster randomized controlled trial, 111 primary care physicians were assigned to intervention or control groups. A validated stigma assessment tool, the Opening Minds Scale for Health Care Providers (OMS-HC), was administered to both groups before and after training. Confidence and comfort were assessed using scales constructed from ad hoc items. In the primary analysis, no significant differences in stigma were found. However, a subscale assessing social distance showed significant improvement in the intervention group after adjustment for a variable (practice size) that was unequally distributed in the randomization. Significant increases in confidence and comfort in managing mental illness were observed among intervention group physicians. A positive correlation was found between increased levels of confidence/comfort and improvements in overall stigma, especially in men. This study provides some preliminary evidence of a positive impact on health care professionals' stigma through a skill-building approach to management of mild to moderate depression and anxiety in primary care. The intervention can be used as a primary vehicle for enhancing comfort and skills in health care providers and, ultimately, reducing an important

  19. The effect of Helicobacter pylori infection and eradication in patients with gastro-oesophageal reflux disease: A parallel-group, double-blind, placebo-controlled multicentre study.

    Science.gov (United States)

    Schwizer, Werner; Menne, Dieter; Schütze, Kurt; Vieth, Michael; Goergens, Reiner; Malfertheiner, Peter; Leodolter, Andreas; Fried, Michael; Fox, Mark R

    2013-08-01

    This study aimed to resolve controversy regarding the effects of Helicobacter pylori eradication therapy and H. pylori infection in gastro-oesophageal reflux disease. A randomized, double-blind, multicentre trial was performed in patients presenting with reflux symptoms. H. pylori-positive patients were randomized to receive either antibiotics or placebo for 7 days. H. pylori-negative patient controls received placebo. All received esomeprazole 20 mg b.d. for 7 days, followed by 40 mg o.d. to complete an 8-week course, and were followed up for 32 weeks by telephone. In this study, 198/589 (34%) patients were H. pylori-positive and 113 H. pylori-negative patients served as controls. Baseline endoscopy revealed 63% Los Angeles grade 0A and 37% Los Angeles grade BCD oesophagitis with no difference between patient groups. Symptom improvement on esomeprazole was seen in 89%. H. pylori eradication was successful in 82%. H. pylori eradication had no effect on symptomatic relapse (hazard ratio 1.15, 95% CI 0.74-1.8; p = 0.5). Overall, H. pylori-positive patients had a lower probability of relapse compared to H. pylori-negative controls (hazard ratio 0.6, 95% CI 0.43-0.85; p = 0.004). Relapse hazard was modulated also by oesophagitis grade (BCD vs. 0A, hazard ratio 2.1, 95% CI 1.5-3.0). Relapse of gastro-oesophageal reflux disease symptoms after a course of high dose acid suppression took longer for H. pylori-positive patients than H. pylori-negative controls; however eradication therapy had no effect on the risk of relapse; ClincialTrials.gov number, NCT00574925.

  20. Double-blind,parallel group, placebo-controlledstudy of Kjellmaniella crassifoliaMiyabe (Gagomein human: The potential of Gagometoactivatethe immune system

    Directory of Open Access Journals (Sweden)

    Jun Nishihira

    2017-10-01

    Full Text Available Background: Marine brown algae, Kjellmaniella crassifolia Miyabe (Gagome is extensively harvested in Northern Japan and is known to help improve the immune system and prevent lifestyle diseases by its functional constituents, particularly the polysaccharide fucoidan. However, since most scientific findings come from animal studies, we examined its potential effectiveness in humans to raise immune functions, using small amounts of Gagome to avoid overconsumption of iodide. Methods: We set up a double-blind, placebo-controlled clinical trial (n=30 subjects for Gagome consumption; n=30 for placebo, in which 0.8 gram/day of Gagome containing 200 mg as dietary fiber (ca. 80 mg as fucoidan was ingested for 8 weeks. The primary end-point was natural killer (NK cell activity while other immune-related biomarkers, such as immunoglobulins (IgM and IgA and cytokines (IL-12 and IFN-g were secondary end-points. Results: No adverse effects were observed during the course of the clinical trial. We found that 8-week daily Gagome intake raised NK cell activities for the group with a relatively higher baseline number of NK cells (p=0.03. We also demonstrated that Gagome intake exerted a tendency to stimulate IgA secretion. These results indicate the possibility that Gagome intake may potentiate host defense systems in human as seen in animal studies. Conclusion: In this study, we used small amounts of Gagome (0.8 g daily as an active test sample to avoid overconsumption of iodide, and found that this amount could enhance NK cell activities, particularly in the subclass with initially higher NK cell numbers. We also found an appreciable increment of IgA. With all of these facts, it seems that Gagome intake activates immune responses that contribute to the promotion of health through stimulation of the immune system.

  1. The combinatorics computation for Casimir operators of the symplectic Lie algebra and the application for determining the center of the enveloping algebra of a semidirect product

    International Nuclear Information System (INIS)

    Le Van Hop.

    1989-12-01

    The combinatorics computation is used to describe the Casimir operators of the symplectic Lie Algebra. This result is applied for determining the Center of the enveloping Algebra of the semidirect Product of the Heisenberg Lie Algebra and the symplectic Lie Algebra. (author). 10 refs

  2. Parallel algorithms

    CERN Document Server

    Casanova, Henri; Robert, Yves

    2008-01-01

    ""…The authors of the present book, who have extensive credentials in both research and instruction in the area of parallelism, present a sound, principled treatment of parallel algorithms. … This book is very well written and extremely well designed from an instructional point of view. … The authors have created an instructive and fascinating text. The book will serve researchers as well as instructors who need a solid, readable text for a course on parallelism in computing. Indeed, for anyone who wants an understandable text from which to acquire a current, rigorous, and broad vi

  3. The electromagnetic Dirac-Fock-Podolsky problem and symplectic properties of the Maxwell and Yang-Mills type dynamical systems

    International Nuclear Information System (INIS)

    Bogolubov, N.N. Jr.; Prykarpatsky, A.K.; Taneri, U.; Prykarpatsky, Y.A.

    2009-01-01

    Based on analysis of reduced geometric structures on fibered manifolds, invariant under action of a certain symmetry group, we construct the symplectic structures associated with connection forms on suitable principal fiber bundles. The application to the non-standard Hamiltonian analysis of the Maxwell and Yang-Mills type dynamical systems is presented. A symplectic reduction theory of the classical Maxwell electromagnetic field equations is formulated, the important Lorentz condition, ensuring the existence of electromagnetic waves, is naturally included into the Hamiltonian picture, thereby solving the well known Dirac, Fock and Podolsky problem. The symplectically reduced Poissonian structures and the related classical minimal interaction principle, concerning the Yang-Mills type equations, are considered. (author)

  4. Analysis of quantum error-correcting codes: Symplectic lattice codes and toric codes

    Science.gov (United States)

    Harrington, James William

    Quantum information theory is concerned with identifying how quantum mechanical resources (such as entangled quantum states) can be utilized for a number of information processing tasks, including data storage, computation, communication, and cryptography. Efficient quantum algorithms and protocols have been developed for performing some tasks (e.g. , factoring large numbers, securely communicating over a public channel, and simulating quantum mechanical systems) that appear to be very difficult with just classical resources. In addition to identifying the separation between classical and quantum computational power, much of the theoretical focus in this field over the last decade has been concerned with finding novel ways of encoding quantum information that are robust against errors, which is an important step toward building practical quantum information processing devices. In this thesis I present some results on the quantum error-correcting properties of oscillator codes (also described as symplectic lattice codes) and toric codes. Any harmonic oscillator system (such as a mode of light) can be encoded with quantum information via symplectic lattice codes that are robust against shifts in the system's continuous quantum variables. I show the existence of lattice codes whose achievable rates match the one-shot coherent information over the Gaussian quantum channel. Also, I construct a family of symplectic self-dual lattices and search for optimal encodings of quantum information distributed between several oscillators. Toric codes provide encodings of quantum information into two-dimensional spin lattices that are robust against local clusters of errors and which require only local quantum operations for error correction. Numerical simulations of this system under various error models provide a calculation of the accuracy threshold for quantum memory using toric codes, which can be related to phase transitions in certain condensed matter models. I also present

  5. Transverse vibration of pipe conveying fluid made of functionally graded materials using a symplectic method

    International Nuclear Information System (INIS)

    Wang, Zhong-Min; Liu, Yan-Zhuang

    2016-01-01

    Highlights: • We investigate the transverse vibration of FGM pipe conveying fluid. • The FGM pipe conveying fluid can be classified into two cases. • The variations between the frequency and the power law exponent are obtained. • “Case 1” is relatively more reasonable than “case 2”. - Abstract: Problems related to the transverse vibration of pipe conveying fluid made of functionally graded material (FGM) are addressed. Based on inside and outside surface material compositions of the pipe, FGM pipe conveying fluid can be classified into two cases. It is hypothesized that the physical parameters of the material along the direction of the pipe wall thickness change in the simple power law. A differential equation of motion expressed in non-dimensional quantities is derived by using Hamilton's principle for systems of changing mass. Using the assuming modal method, the pipe deflection function is expanded into a series, in which each term is expressed to admissible function multiplied by generalized coordinate. Then, the differential equation of motion is discretized into the two order differential equations expressed in the generalized coordinates. Based on symplectic elastic theory and the introduction of dual system and dual variable, Hamilton's dual equations are derived, and the original problem is reduced to eigenvalue and eigenvector problem in the symplectic space. Finally, a symplectic method is employed to analyze the vibration and stability of FGM pipe conveying fluid. For a clamped–clamped FGM pipe conveying fluid in “case 1” and “case 2”, the dimensionless critical flow velocity for first-mode divergence and the critical coupled-mode flutter flow velocity are obtained, and the variations between the real part and imaginary part of dimensionless complex frequency and fluid velocity, mass ratio and the power law exponent (or graded index, volume fraction) for FGM pipe conveying fluid are analyzed.

  6. Transverse vibration of pipe conveying fluid made of functionally graded materials using a symplectic method

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhong-Min, E-mail: wangzhongm@xaut.edu.cn; Liu, Yan-Zhuang

    2016-03-15

    Highlights: • We investigate the transverse vibration of FGM pipe conveying fluid. • The FGM pipe conveying fluid can be classified into two cases. • The variations between the frequency and the power law exponent are obtained. • “Case 1” is relatively more reasonable than “case 2”. - Abstract: Problems related to the transverse vibration of pipe conveying fluid made of functionally graded material (FGM) are addressed. Based on inside and outside surface material compositions of the pipe, FGM pipe conveying fluid can be classified into two cases. It is hypothesized that the physical parameters of the material along the direction of the pipe wall thickness change in the simple power law. A differential equation of motion expressed in non-dimensional quantities is derived by using Hamilton's principle for systems of changing mass. Using the assuming modal method, the pipe deflection function is expanded into a series, in which each term is expressed to admissible function multiplied by generalized coordinate. Then, the differential equation of motion is discretized into the two order differential equations expressed in the generalized coordinates. Based on symplectic elastic theory and the introduction of dual system and dual variable, Hamilton's dual equations are derived, and the original problem is reduced to eigenvalue and eigenvector problem in the symplectic space. Finally, a symplectic method is employed to analyze the vibration and stability of FGM pipe conveying fluid. For a clamped–clamped FGM pipe conveying fluid in “case 1” and “case 2”, the dimensionless critical flow velocity for first-mode divergence and the critical coupled-mode flutter flow velocity are obtained, and the variations between the real part and imaginary part of dimensionless complex frequency and fluid velocity, mass ratio and the power law exponent (or graded index, volume fraction) for FGM pipe conveying fluid are analyzed.

  7. Symplectic Integrators to Stochastic Hamiltonian Dynamical Systems Derived from Composition Methods

    Directory of Open Access Journals (Sweden)

    Tetsuya Misawa

    2010-01-01

    Full Text Available “Symplectic” schemes for stochastic Hamiltonian dynamical systems are formulated through “composition methods (or operator splitting methods” proposed by Misawa (2001. In the proposed methods, a symplectic map, which is given by the solution of a stochastic Hamiltonian system, is approximated by composition of the stochastic flows derived from simpler Hamiltonian vector fields. The global error orders of the numerical schemes derived from the stochastic composition methods are provided. To examine the superiority of the new schemes, some illustrative numerical simulations on the basis of the proposed schemes are carried out for a stochastic harmonic oscillator system.

  8. From Stein to Weinstein and back symplectic geometry of affine complex manifolds

    CERN Document Server

    Cieliebak, Kai

    2013-01-01

    A beautiful and comprehensive introduction to this important field. -Dusa McDuff, Barnard College, Columbia University This excellent book gives a detailed, clear, and wonderfully written treatment of the interplay between the world of Stein manifolds and the more topological and flexible world of Weinstein manifolds. Devoted to this subject with a long history, the book serves as a superb introduction to this area and also contains the authors' new results. -Tomasz Mrowka, MIT This book is devoted to the interplay between complex and symplectic geometry in affine complex manifolds. Affine co

  9. Symplectic Group Representation of the Two-Mode Squeezing Operator in the Coherent State Basis

    Science.gov (United States)

    Fan, Hong-Yi; Chen, Jun-Hua

    2003-11-01

    We find that the coherent state projection operator representation of the two-mode squeezing operator constitutes a loyal group representation of symplectic group, which is a remarkable property of the coherent state. As a consequence, the resultant effect of successively applying two-mode squeezing operators are equivalent to a single squeezing in the two-mode Fock space. Generalization of this property to the 2n-mode case is also discussed. The project supported by National Natural Science Foundation of China under Grant No. 10575057

  10. The symplectic algorithm for use in a model of laser field

    International Nuclear Information System (INIS)

    Liu Xiaoyan; Liu Xueshen; Ding Peizhu; Zhou Zhongyuan

    2002-01-01

    Using the asymptotic boundary condition the time-dependent Schroedinger equations with initial conditions in the infinite space can be transformed into the problem with initial and boundary conditions, and it can further be discrected into the inhomogeneous canonic equations. The symplectic algorithms to solve the inhomogeneous canonic equations have been developed and adopted to compute the high-order harmonics of one-dimensional Hydrogen in the laser field. We noticed that there is saturation intensity for generating high-order harmonics, which are agree with previous results, and there is a relationship between harmonics and bound state probabilities

  11. Construction of nonlinear symplectic six-dimensional thin-lens maps by exponentiation

    CERN Document Server

    Heinemann, K; Schmidt, F

    1995-01-01

    The aim of this paper is to construct six-dimensional symplectic thin-lens transport maps for the tracking program SIXTRACK, continuing an earlier report by using another method which consistes in applying Lie series and exponentiation as described by W. Groebner and for canonical systems by A.J. Dragt. We firstly use an approximate Hamiltonian obtained by a series expansion of the square root. Furthermore, nonlinear crossing terms due to the curvature in bending magnets are neglected. An improved Hamiltonian, excluding solenoids, is introduced in Appendix A by using the unexpanded square root mentioned above, but neglecting again nonlinear crossing terms...

  12. Fast symplectic mapping and quasi-invariants for the Large Hadron Collider

    International Nuclear Information System (INIS)

    Warnock, R.L.; Berg, J.S.; Forest, E.

    1995-05-01

    Beginning with a tracking code for the LHC, we construct the canonical generator of the full-turn map in polar coordinates. For very fast mapping we adopt a model in which the momentum is modulated sinusoidally with a period of 130 turns (very close to the synchrotron period). We achieve symplectic mapping of 10 7 turns in 3.6 hours on a workstation. Quasi-invariant tori are constructed on the Poincare section corresponding to multiples of the synchrotron period. The possible use of quasi-invariants in derivin, long-term bounds on the motion is discussed

  13. A Survey of Symplectic and Collocation Integration Methods for Orbit Propagation

    Science.gov (United States)

    Jones, Brandon A.; Anderson, Rodney L.

    2012-01-01

    Demands on numerical integration algorithms for astrodynamics applications continue to increase. Common methods, like explicit Runge-Kutta, meet the orbit propagation needs of most scenarios, but more specialized scenarios require new techniques to meet both computational efficiency and accuracy needs. This paper provides an extensive survey on the application of symplectic and collocation methods to astrodynamics. Both of these methods benefit from relatively recent theoretical developments, which improve their applicability to artificial satellite orbit propagation. This paper also details their implementation, with several tests demonstrating their advantages and disadvantages.

  14. Symplectic no-core shell-model approach to intermediate-mass nuclei

    Science.gov (United States)

    Tobin, G. K.; Ferriss, M. C.; Launey, K. D.; Dytrych, T.; Draayer, J. P.; Dreyfuss, A. C.; Bahri, C.

    2014-03-01

    We present a microscopic description of nuclei in the intermediate-mass region, including the proximity to the proton drip line, based on a no-core shell model with a schematic many-nucleon long-range interaction with no parameter adjustments. The outcome confirms the essential role played by the symplectic symmetry to inform the interaction and the winnowing of shell-model spaces. We show that it is imperative that model spaces be expanded well beyond the current limits up through 15 major shells to accommodate particle excitations, which appear critical to highly deformed spatial structures and the convergence of associated observables.

  15. Quantization of a symplectic manifold associated to a manifold with projective structure

    International Nuclear Information System (INIS)

    Biswas, Indranil

    2009-01-01

    Let X be a complex manifold equipped with a projective structure P. There is a holomorphic principal C*-bundle L P ' over X associated with P. We show that the holomorphic cotangent bundle of the total space of L P ' equipped with the Liouville symplectic form has a canonical deformation quantization. This generalizes the construction in the work of and Ben-Zvi and Biswas [''A quantization on Riemann surfaces with projective structure,'' Lett. Math. Phys. 54, 73 (2000)] done under the assumption that dim C X=1.

  16. Orthogonal and symplectic Yangians and Yang–Baxter R-operators

    Directory of Open Access Journals (Sweden)

    A.P. Isaev

    2016-03-01

    Full Text Available Yang–Baxter R operators symmetric with respect to the orthogonal and symplectic algebras are considered in an uniform way. Explicit forms for the spinorial and metaplectic R operators are obtained. L operators, obeying the RLL relation with the orthogonal or symplectic fundamental R matrix, are considered in the interesting cases, where their expansion in inverse powers of the spectral parameter is truncated. Unlike the case of special linear algebra symmetry the truncation results in additional conditions on the Lie algebra generators of which the L operators is built and which can be fulfilled in distinguished representations only. Further, generalized L operators, obeying the modified RLL relation with the fundamental R matrix replaced by the spinorial or metaplectic one, are considered in the particular case of linear dependence on the spectral parameter. It is shown how by fusion with respect to the spinorial or metaplectic representation these first order spinorial L operators reproduce the ordinary L operators with second order truncation.

  17. Variational symplectic algorithm for guiding center dynamics in the inner magnetosphere

    International Nuclear Information System (INIS)

    Li Jinxing; Pu Zuyin; Xie Lun; Fu Suiyan; Qin Hong

    2011-01-01

    Charged particle dynamics in magnetosphere has temporal and spatial multiscale; therefore, numerical accuracy over a long integration time is required. A variational symplectic integrator (VSI) [H. Qin and X. Guan, Phys. Rev. Lett. 100, 035006 (2008) and H. Qin, X. Guan, and W. M. Tang, Phys. Plasmas 16, 042510 (2009)] for the guiding-center motion of charged particles in general magnetic field is applied to study the dynamics of charged particles in magnetosphere. Instead of discretizing the differential equations of the guiding-center motion, the action of the guiding-center motion is discretized and minimized to obtain the iteration rules for advancing the dynamics. The VSI conserves exactly a discrete Lagrangian symplectic structure and has better numerical properties over a long integration time, compared with standard integrators, such as the standard and adaptive fourth order Runge-Kutta (RK4) methods. Applying the VSI method to guiding-center dynamics in the inner magnetosphere, we can accurately calculate the particles'orbits for an arbitrary long simulating time with good conservation property. When a time-independent convection and corotation electric field is considered, the VSI method can give the accurate single particle orbit, while the RK4 method gives an incorrect orbit due to its intrinsic error accumulation over a long integrating time.

  18. Associated quantum vector bundles and symplectic structure on a quantum space

    International Nuclear Information System (INIS)

    Coquereaux, R.; Garcia, A.O.; Trinchero, R.

    2000-01-01

    We define a quantum generalization of the algebra of functions over an associated vector bundle of a principal bundle. Here the role of a quantum principal bundle is played by a Hopf-Galois extension. Smash products of an algebra times a Hopf algebra H are particular instances of these extensions, and in these cases we are able to define a differential calculus over their associated vector bundles without requiring the use of a (bicovariant) differential structure over H. Moreover, if H is coquasitriangular, it coacts naturally on the associated bundle, and the differential structure is covariant. We apply this construction to the case of the finite quotient of the SL q (2) function Hopf algebra at a root of unity (q 3 = 1) as the structure group, and a reduced 2-dimensional quantum plane as both the 'base manifold' and fibre, getting an algebra which generalizes the notion of classical phase space for this quantum space. We also build explicitly a differential complex for this phase space algebra, and find that levels 0 and 2 support a (co)representation of the quantum symplectic group. On this phase space we define vector fields, and with the help of the Sp q structure we introduce a symplectic form relating 1-forms to vector fields. This leads naturally to the introduction of Poisson brackets, a necessary step to do 'classical' mechanics on a quantum space, the quantum plane. (author)

  19. The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study.

    Science.gov (United States)

    Ghali, Jalal K; Orlandi, Cesare; Abraham, William T

    2012-06-01

    Volume overload is the dominant feature of decompensated heart failure (HF) and it often results in adverse clinical outcomes. Vasopressin receptor antagonists such as lixivaptan may provide effective volume unloading. This study assessed weight loss after 1 day and 8 weeks of treatment with lixivaptan in outpatients with HF and volume overload. This phase II, 8-week, multicentre, double-blind, parallel-group study randomized participants (2:1) to receive lixivaptan 100 mg or placebo once daily (in addition to standard HF therapy). Body weight and cardiovascular assessments were made at baseline, Day 1 (not cardiovascular), Weeks 1, 2, 4, and 8, and 7 days post-treatment. The Trail-making Test, part B (TMT-B) and the Medical Outcomes Survey 6-item cognitive function scale (MOS-6) were assessed at baseline and Week 4. The study randomized 170 participants (lixivaptan, n = 111; placebo, n = 59). Most (97.1%) were receiving pharmacological therapy for HF at baseline. Demographic characteristics were generally similar between the two groups. Body weight decreased significantly from baseline to Day 1 with lixivaptan vs. placebo (least-square mean change ± standard error: - 0.38 ± 0.08 kg vs. +0.13 ± 0.11 kg; P overload, lixivaptan 100 mg once daily, when added to standard therapy, reduced body weight, improved dyspnoea and orthopnoea, and was well tolerated. NCT01055912.

  20. Efficacy and safety of rasagiline as an adjunct to levodopa treatment in Chinese patients with Parkinson's disease: a randomized, double-blind, parallel-controlled, multi-centre trial.

    Science.gov (United States)

    Zhang, Lina; Zhang, Zhiqin; Chen, Yangmei; Qin, Xinyue; Zhou, Huadong; Zhang, Chaodong; Sun, Hongbin; Tang, Ronghua; Zheng, Jinou; Yi, Lin; Deng, Liying; Li, Jinfang

    2013-08-01

    Rasagiline mesylate is a highly potent, selective and irreversible monoamine oxidase type B (MAOB) inhibitor and is effective as monotherapy or adjunct to levodopa for patients with Parkinson's disease (PD). However, few studies have evaluated the efficacy and safety of rasagiline in the Chinese population. This study was designed to investigate the safety and efficacy of rasagiline as adjunctive therapy to levodopa treatment in Chinese PD patients. This was a randomized, double-blind, placebo-controlled, parallel-group, multi-centre trial conducted over a 12-wk period that enrolled 244 PD patients with motor fluctuations. Participants were randomly assigned to oral rasagiline mesylate (1 mg) or placebo, once daily. Altogether, 219 patients completed the trial. Rasagiline showed significantly greater efficacy compared with placebo. During the treatment period, the primary efficacy variable--mean adjusted total daily off time--decreased from baseline by 1.7 h in patients treated with 1.0 mg/d rasagiline compared to placebo (p rasagiline treatment. Rasagiline was well tolerated. This study demonstrated that rasagiline mesylate is effective and well tolerated as an adjunct to levodopa treatment in Chinese PD patients with fluctuations.

  1. A Herbal Medicine, Gongjindan, in Subjects with Chronic Dizziness (GOODNESS Study: Study Protocol for a Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Clinical Trial for Effectiveness, Safety, and Cost-Effectiveness

    Directory of Open Access Journals (Sweden)

    Seungwon Shin

    2017-01-01

    Full Text Available This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication, Gongjindan (GJD, in patients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight patients diagnosed with Meniere’s disease, psychogenic dizziness, or dizziness of unknown cause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g GJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory score. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale and frequency of dizziness, balance function (Berg Balance Scale, fatigue (Fatigue Severity Scale and deficiency pattern/syndrome (qi blood yin yang-deficiency questionnaire levels, and depression (Korean version of Beck’s Depression Inventory and anxiety (State-Trait Anxiety Inventory levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the incremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensions’ questionnaire and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided. This trial is registered with ClinicalTrials.gov NCT03219515, in July 2017.

  2. A low-fat yoghurt supplemented with a rooster comb extract on muscle joint function in adults with mild knee pain: a randomized, double blind, parallel, placebo-controlled, clinical trial of efficacy.

    Science.gov (United States)

    Solà, Rosa; Valls, Rosa-Maria; Martorell, Isabel; Giralt, Montserrat; Pedret, Anna; Taltavull, Núria; Romeu, Marta; Rodríguez, Àurea; Moriña, David; Lopez de Frutos, Victor; Montero, Manuel; Casajuana, Maria-Carmen; Pérez, Laura; Faba, Jenny; Bernal, Gloria; Astilleros, Anna; González, Roser; Puiggrós, Francesc; Arola, Lluís; Chetrit, Carlos; Martinez-Puig, Daniel

    2015-11-01

    Preliminary results suggested that oral-administration of rooster comb extract (RCE) rich in hyaluronic acid (HA) was associated with improved muscle strength. Following these promising results, the objective of the present study was to evaluate the effect of low-fat yoghurt supplemented with RCE rich in HA on muscle function in adults with mild knee pain; a symptom of early osteoarthritis. Participants (n = 40) received low-fat yoghurt (125 mL d(-1)) supplemented with 80 mg d(-1) of RCE and the placebo group (n = 40) consumed the same yoghurt without the RCE, in a randomized, controlled, double-blind, parallel trial over 12 weeks. Using an isokinetic dynamometer (Biodex System 4), RCE consumption, compared to control, increased the affected knee peak torque, total work and mean power at 180° s(-1), at least 11% in men (p < 0.05) with no differences in women. No dietary differences were noted. These results suggest that long-term consumption of low-fat yoghurt supplemented with RCE could be a dietary tool to improve muscle strength in men, associated with possible clinical significance. However, further studies are needed to elucidate reasons for these sex difference responses observed, and may provide further insight into muscle function.

  3. Reduction of a symplectic-like Lie algebroid with momentum map and its application to fiberwise linear Poisson structures

    International Nuclear Information System (INIS)

    Marrero, Juan Carlos; Padrón, Edith; Rodríguez-Olmos, Miguel

    2012-01-01

    This paper addresses the problem of developing an extension of the Marsden–Weinstein reduction process to symplectic-like Lie algebroids, and in particular to the case of the canonical cover of a fiberwise linear Poisson structure, whose reduction process is the analog to cotangent bundle reduction in the context of Lie algebroids. Dedicated to the memory of Jerrold E Marsden (paper)

  4. Variational Symplectic Integrator for Long-Time Simulations of the Guiding-Center Motion of Charged Particles in General Magnetic Fields

    International Nuclear Information System (INIS)

    Qin Hong; Guan Xiaoyin

    2008-01-01

    A variational symplectic integrator for the guiding-center motion of charged particles in general magnetic fields is developed for long-time simulation studies of magnetized plasmas. Instead of discretizing the differential equations of the guiding-center motion, the action of the guiding-center motion is discretized and minimized to obtain the iteration rules for advancing the dynamics. The variational symplectic integrator conserves exactly a discrete Lagrangian symplectic structure, and has better numerical properties over long integration time, compared with standard integrators, such as the standard and variable time-step fourth order Runge-Kutta methods

  5. Variational Symplectic Integrator for Long-Time Simulations of the Guiding-Center Motion of Charged Particles in General Magnetic Fields

    International Nuclear Information System (INIS)

    Qin, H.; Guan, X.

    2008-01-01

    A variational symplectic integrator for the guiding-center motion of charged particles in general magnetic fields is developed for long-time simulation studies of magnetized plasmas. Instead of discretizing the differential equations of the guiding-center motion, the action of the guiding-center motion is discretized and minimized to obtain the iteration rules for advancing the dynamics. The variational symplectic integrator conserves exactly a discrete Lagrangian symplectic structure, and has better numerical properties over long integration time, compared with standard integrators, such as the standard and variable time-step fourth order Runge-Kutta methods.

  6. Symplectic approach to calculation of magnetic field line trajectories in physical space with realistic magnetic geometry in divertor tokamaks

    Science.gov (United States)

    Punjabi, Alkesh; Ali, Halima

    2008-12-01

    A new approach to integration of magnetic field lines in divertor tokamaks is proposed. In this approach, an analytic equilibrium generating function (EGF) is constructed in natural canonical coordinates (ψ,θ) from experimental data from a Grad-Shafranov equilibrium solver for a tokamak. ψ is the toroidal magnetic flux and θ is the poloidal angle. Natural canonical coordinates (ψ,θ,φ) can be transformed to physical position (R,Z,φ) using a canonical transformation. (R,Z,φ) are cylindrical coordinates. Another canonical transformation is used to construct a symplectic map for integration of magnetic field lines. Trajectories of field lines calculated from this symplectic map in natural canonical coordinates can be transformed to trajectories in real physical space. Unlike in magnetic coordinates [O. Kerwin, A. Punjabi, and H. Ali, Phys. Plasmas 15, 072504 (2008)], the symplectic map in natural canonical coordinates can integrate trajectories across the separatrix surface, and at the same time, give trajectories in physical space. Unlike symplectic maps in physical coordinates (x,y) or (R,Z), the continuous analog of a symplectic map in natural canonical coordinates does not distort trajectories in toroidal planes intervening the discrete map. This approach is applied to the DIII-D tokamak [J. L. Luxon and L. E. Davis, Fusion Technol. 8, 441 (1985)]. The EGF for the DIII-D gives quite an accurate representation of equilibrium magnetic surfaces close to the separatrix surface. This new approach is applied to demonstrate the sensitivity of stochastic broadening using a set of perturbations that generically approximate the size of the field errors and statistical topological noise expected in a poloidally diverted tokamak. Plans for future application of this approach are discussed.

  7. Symplectic approach to calculation of magnetic field line trajectories in physical space with realistic magnetic geometry in divertor tokamaks

    International Nuclear Information System (INIS)

    Punjabi, Alkesh; Ali, Halima

    2008-01-01

    A new approach to integration of magnetic field lines in divertor tokamaks is proposed. In this approach, an analytic equilibrium generating function (EGF) is constructed in natural canonical coordinates (ψ,θ) from experimental data from a Grad-Shafranov equilibrium solver for a tokamak. ψ is the toroidal magnetic flux and θ is the poloidal angle. Natural canonical coordinates (ψ,θ,φ) can be transformed to physical position (R,Z,φ) using a canonical transformation. (R,Z,φ) are cylindrical coordinates. Another canonical transformation is used to construct a symplectic map for integration of magnetic field lines. Trajectories of field lines calculated from this symplectic map in natural canonical coordinates can be transformed to trajectories in real physical space. Unlike in magnetic coordinates [O. Kerwin, A. Punjabi, and H. Ali, Phys. Plasmas 15, 072504 (2008)], the symplectic map in natural canonical coordinates can integrate trajectories across the separatrix surface, and at the same time, give trajectories in physical space. Unlike symplectic maps in physical coordinates (x,y) or (R,Z), the continuous analog of a symplectic map in natural canonical coordinates does not distort trajectories in toroidal planes intervening the discrete map. This approach is applied to the DIII-D tokamak [J. L. Luxon and L. E. Davis, Fusion Technol. 8, 441 (1985)]. The EGF for the DIII-D gives quite an accurate representation of equilibrium magnetic surfaces close to the separatrix surface. This new approach is applied to demonstrate the sensitivity of stochastic broadening using a set of perturbations that generically approximate the size of the field errors and statistical topological noise expected in a poloidally diverted tokamak. Plans for future application of this approach are discussed.

  8. Parallel computation

    International Nuclear Information System (INIS)

    Jejcic, A.; Maillard, J.; Maurel, G.; Silva, J.; Wolff-Bacha, F.

    1997-01-01

    The work in the field of parallel processing has developed as research activities using several numerical Monte Carlo simulations related to basic or applied current problems of nuclear and particle physics. For the applications utilizing the GEANT code development or improvement works were done on parts simulating low energy physical phenomena like radiation, transport and interaction. The problem of actinide burning by means of accelerators was approached using a simulation with the GEANT code. A program of neutron tracking in the range of low energies up to the thermal region has been developed. It is coupled to the GEANT code and permits in a single pass the simulation of a hybrid reactor core receiving a proton burst. Other works in this field refers to simulations for nuclear medicine applications like, for instance, development of biological probes, evaluation and characterization of the gamma cameras (collimators, crystal thickness) as well as the method for dosimetric calculations. Particularly, these calculations are suited for a geometrical parallelization approach especially adapted to parallel machines of the TN310 type. Other works mentioned in the same field refer to simulation of the electron channelling in crystals and simulation of the beam-beam interaction effect in colliders. The GEANT code was also used to simulate the operation of germanium detectors designed for natural and artificial radioactivity monitoring of environment

  9. Symplectic finite element scheme: application to a driven problem with a regular singularity

    Energy Technology Data Exchange (ETDEWEB)

    Pletzer, A. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1996-02-01

    A new finite element (FE) scheme, based on the decomposition of a second order differential equation into a set of first order symplectic (Hamiltonian) equations, is presented and tested on one-dimensional, driven Sturm-Liouville problem. Error analysis shows improved cubic convergence in the energy norm for piecewise linear `tent` elements, as compared to quadratic convergence for the standard and hybrid FE methods. The convergence deteriorates in the presence of a regular singular point, but can be recovered by appropriate mesh node packing. Optimal mesh packing exponents are derived to ensure cubic (respectively quadratic) convergence with minimal numerical error. A further suppression of the numerical error by a factor proportional to the square of the leading exponent of the singular solution, is achieved for a model problem based on determining the nonideal magnetohydrodynamic stability of a fusion plasma. (author) 7 figs., 14 refs.

  10. Symplectic finite element scheme: application to a driven problem with a regular singularity

    International Nuclear Information System (INIS)

    Pletzer, A.

    1996-02-01

    A new finite element (FE) scheme, based on the decomposition of a second order differential equation into a set of first order symplectic (Hamiltonian) equations, is presented and tested on one-dimensional, driven Sturm-Liouville problem. Error analysis shows improved cubic convergence in the energy norm for piecewise linear 'tent' elements, as compared to quadratic convergence for the standard and hybrid FE methods. The convergence deteriorates in the presence of a regular singular point, but can be recovered by appropriate mesh node packing. Optimal mesh packing exponents are derived to ensure cubic (respectively quadratic) convergence with minimal numerical error. A further suppression of the numerical error by a factor proportional to the square of the leading exponent of the singular solution, is achieved for a model problem based on determining the nonideal magnetohydrodynamic stability of a fusion plasma. (author) 7 figs., 14 refs

  11. Explicit higher order symplectic integrator for s-dependent magnetic field

    International Nuclear Information System (INIS)

    Wu, Y.; Forest, E.; Robin, D.S.

    2001-01-01

    We derive second and higher order explicit symplectic integrators for the charged particle motion in an s-dependent magnetic field with the paraxial approximation. The Hamiltonian of such a system takes the form of H (summation) k (p k - a k (rvec q), s) 2 + V((rvec q), s). This work solves a long-standing problem for modeling s-dependent magnetic elements. Important applications of this work include the studies of the charged particle dynamics in a storage ring with strong field wigglers, arbitrarily polarized insertion devices,and super-conducting magnets with strong fringe fields. Consequently, this work will have a significant impact on the optimal use of the above magnetic devices in the light source rings as well as in next generation linear collider damping rings

  12. Construction of symplectic full-turn maps by application of an arbitrary tracking code

    International Nuclear Information System (INIS)

    Warnock, R.L.

    1989-03-01

    A map to describe propagation of particles through any section of a nonlinear lattice may be represented as a Taylor expansion about the origin in phase space. Although the technique to compute the Taylor coefficients has been improved recently, the expansion may fail to provide adequate accuracy in regions where nonlinear effects are substantial. A representation of the map in angle-action coordinates, with the angle dependence given by a Fourier series, and the action dependence by polynomials in I/sup 1/2/, may be more successful. Maps of this form are easily constructed by taking Fourier transforms of results from an arbitrary symplectic tracking code. Examples are given of one-turn and two turn maps for the SLC North Damping Ring in a strongly nonlinear region. Results for accuracy and speed of evaluation of the maps are quite encouraging. It seems feasible to make accurate maps for the SSC by this method. 9 refs., 1 tab

  13. Efficacy of treatment of insomnia in migraineurs with eszopiclone (Lunesta®) and its effect on total sleep time, headache frequency, and daytime functioning: A randomized, double-blind, placebo-controlled, parallel-group, pilot study.

    Science.gov (United States)

    Spierings, Egilius L H; McAllister, Peter J; Bilchik, Tanya R

    2015-04-01

    A review on headache and insomnia revealed that insomnia is a risk factor for increased headache frequency and headache intensity in migraineurs. The authors designed a randomized, double blind, placebo-controlled, parallel-group, pilot study in which migraineurs who also had insomnia were enrolled, to test this observation. In the study, the authors treated 79 subjects with IHS-II migraine with and/or without aura and with DSM-IV primary insomnia for 6 weeks with 3 mg eszopiclone (Lunesta(®)) or placebo at bedtime. The treatment was preceded by a 2-week baseline period and followed by a 2-week run-out period. Of the 79 subjects treated, 75 were evaluable, 35 in the eszopiclone group, and 40 in the placebo group. At baseline, the groups were comparable except for sleep latency. Of the three remaining sleep variables, total sleep time, nighttime awakenings, and sleep quality, the number of nighttime awakenings during the 6-week treatment period was significantly lower in the eszopiclone group than in the placebo group (P = 0.03). Of the three daytime variables, alertness, fatigue, and functioning, this was also the case for fatigue (P = 005). The headache variables, frequency, duration, and intensity, did not show a difference from placebo during the 6-week treatment period. The study did not meet primary endpoint, that is, the difference in total sleep time during the 6-week treatment period between eszopiclone and placebo was less than 40 minutes. Therefore, it failed to answer the question as to whether insomnia is, indeed, a risk factor for increased headache frequency and headache intensity in migraineurs.

  14. Effects on hemodynamics and gas exchange of omega-3 fatty acid-enriched lipid emulsion in acute respiratory distress syndrome (ARDS: a prospective, randomized, double-blind, parallel group study

    Directory of Open Access Journals (Sweden)

    Sacanell Judit

    2008-10-01

    Full Text Available Abstract Introduction We investigated the effects on hemodynamics and gas exchange of a lipid emulsion enriched with omega-3 fatty acids in patients with ARDS. Methods The design was a prospective, randomized, double-blind, parallel group study in our Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain. We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men and 2 women; mean age: 58 ± 13 years; APACHE II score: 17.8 ± 2.3; Lung Injury Score: 3.1 ± 0.5; baseline PaO2/FiO2 ratio: 149 ± 40. Patients were randomized into 2 groups: Group A (n = 8 received the study emulsion Lipoplus® 20%, B.Braun Medical (50% MCT, 40% LCT, 10% ω-3; Group B (n = 8 received the control emulsion Intralipid® Fresenius Kabi (100% LCT. Lipid emulsions were administered during 12 h at a dose of 0.12 g/kg/h. Measurements of the main hemodynamic and gas exchange parameters were made at baseline (immediately before administration of the lipid emulsions, every hour during the lipid infusion, at the end of administration, and six hours after the end of administration lipid infusion. Results No statistically significant changes were observed in the different hemodynamic values analyzed. Likewise, the gas exchange parameters did not show statistically significant differences during the study. No adverse effect attributable to the lipid emulsions was seen in the patients analyzed. Conclusion The lipid emulsion enriched with omega-3 fatty acids was safe and well tolerated in short-term administration to patients with ARDS. It did not cause any significant changes in hemodynamic and gas exchange parameters. Trial registration ISRCTN63673813

  15. Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication.

    Science.gov (United States)

    Kawashima, Makoto; Sato, Shinichi; Furukawa, Fukumi; Matsunaga, Kayoko; Akamatsu, Hirohiko; Igarashi, Atsuyuki; Tsunemi, Yuichiro; Hayashi, Nobukazu; Yamamoto, Yuki; Nagare, Toshitaka; Katsuramaki, Tsuneo

    2017-07-01

    A placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study was conducted to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris. Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. All 609 subjects were randomly assigned to receive the study products (2.5% and 5% BPO and placebo), and 607 subjects were included in the full analysis set, 544 in the per protocol set and 609 in the safety analyses. The median rates of reduction from baseline to the last evaluation of the inflammatory lesion counts, the primary end-point, in the 2.5% and 5% BPO groups were 72.7% and 75.0%, respectively, and were significantly higher than that in the placebo group (41.7%). No deaths or other serious adverse events were observed. The incidences of adverse events in the 2.5% and 5% BPO groups were 56.4% and 58.8%, respectively; a higher incidence than in the placebo group, but there was no obvious difference between the 2.5% and 5% BPO groups. All adverse events were mild or moderate in severity. Most adverse events did not lead to study product discontinuation. The results suggested that both 2.5% and 5% BPO are useful for the treatment of acne vulgaris. © 2017 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd.

  16. A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.

    Science.gov (United States)

    Amalraj, Augustine; Varma, Karthik; Jacob, Joby; Divya, Chandradhara; Kunnumakkara, Ajaikumar B; Stohs, Sidney J; Gopi, Sreeraj

    2017-10-01

    Rheumatoid arthritis (RA) is an autoimmune, chronic systemic inflammatory disorder. The long-term use of currently available drugs for the treatment of RA has many potential side effects. Natural phytonutrients may serve as alternative strategies for the safe and effective treatment of RA, and curcuminoids have been used in Ayurvedic medicine for the treatment of inflammatory conditions for centuries. In this study, a novel, highly bioavailable form of curcumin in a completely natural turmeric matrix was evaluated for its ability to improve the clinical symptoms of RA. A randomized, double-blind, placebo-controlled, three-arm, parallel-group study was conducted to evaluate the comparative efficacy of two different doses of curcumin with that of a placebo in active RA patients. Twelve patients in each group received placebo, 250 or 500 mg of the curcumin product twice daily for 90 days. The responses of the patients were assessed using the American College of Rheumatology (ACR) response, visual analog scale (VAS), C-reactive protein (CRP), Disease Activity Score 28 (DAS28), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) values. RA patients who received the curcumin product at both low and high doses reported statistically significant changes in their clinical symptoms at the end of the study. These observations were confirmed by significant changes in ESR, CPR, and RF values in patients receiving the study product compared to baseline and placebo. The results indicate that this novel curcumin in a turmeric matrix acts as an analgesic and anti-inflammatory agent for the management of RA at a dose as low as 250 mg twice daily as evidenced by significant improvement in the ESR, CRP, VAS, RF, DAS28, and ACR responses compared to placebo. Both doses of the study product were well tolerated and without side effects.

  17. Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol).

    Science.gov (United States)

    Ellegaard, Pernille Kempel; Licht, Rasmus Wentzer; Poulsen, Henrik Enghusen; Nielsen, René Ernst; Berk, Michael; Dean, Olivia May; Mohebbi, Mohammadreza; Nielsen, Connie Thuroee

    2018-04-05

    Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depressive episodes, especially compared with the efficacy of treatment for acute mania. N-Acetylcysteine (NAC) has been explored for psychiatric disorders for some time given its antioxidant and anti-inflammatory properties. The current trial aims at testing the clinical effects of adjunctive NAC treatment (compared to placebo) for bipolar depression. We will also explore the biological effects of NAC in this context. We hypothesize that adjunctive NAC treatment will reduce symptoms of depression, which will be reflected by changes in selected markers of oxidative stress. In the study, we will include adults diagnosed with bipolar disorder, in a currently depressive episode. Participants will undertake a 20-week, adjunctive, randomized, double-blinded, parallel group placebo-controlled trial comparing 3 grams of adjunctive NAC daily with placebo. The primary outcome is the mean change over time from baseline to end of study on the Montgomery-Asberg Depression Rating Scale (MADRS). Among the secondary outcomes are mean changes from baseline to end of study on the Bech-Rafaelsen Melancholia Scale (MES), the Young Mania Rating Scale (YMRS), the WHO-Five Well-being Index (WHO-5), the Global Assessment of Functioning scale (GAF-F), the Global Assessment of Symptoms scale (GAF-S) and the Clinical Global Impression-Severity scale (CGI-S). The potential effects on oxidative stress by NAC treatment will be measured through urine and blood samples. DNA will be examined for potential polymorphisms related to oxidative defences. Registered at The European Clinical Trials Database, ClinicalTrials.gov: NCT02294591 and The Danish Data Protection Agency: 2008-58-0035.

  18. A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects.

    Science.gov (United States)

    Berg, Jolene Kay; Kim, Eric H; Li, Benjamin; Joelsson, Bo; Youssef, Nader N

    2014-02-12

    Teduglutide, a recombinant analog of human glucagon-like peptide (GLP)-2, is a novel therapy recently approved for the treatment of adult patients with short bowel syndrome who are dependent on parenteral support. Previous studies assessing the effect of GLP-2 on gastric emptying in humans have yielded inconsistent results, with some studies showing no effect and others documenting a GLP-2-dependent delay in gastric emptying. The primary objective of this study was to assess the effect of teduglutide on gastric emptying of liquids in healthy subjects, as measured by the pharmacokinetics of acetaminophen. This double-blind, parallel-group, single-center study enrolled and randomized 36 healthy subjects (22 men, 14 women) to receive subcutaneous doses of teduglutide 4 mg or placebo (2:1 ratio; 23:13) once daily on Days 1 through 10 in the morning. Gastric emptying of a mixed nutrient liquid meal was assessed by measuring acetaminophen levels predose and at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 3.5, 4, 5, 6, 8, 10, 12, and 14 hours after administration of 1000 mg acetaminophen on Days 0 and 10. The primary study endpoint was a pharmacokinetic analysis of acetaminophen absorption in subjects receiving teduglutide or placebo. No significant differences in gastric emptying of liquids (acetaminophen area under the concentration [AUC] vs time curve from time 0 to the last measurable concentration, AUC extrapolated to infinity, maximum concentration [Cmax], and time to Cmax) were observed on Day 10 in subjects receiving teduglutide 4 mg versus subjects receiving placebo. There were no serious adverse events (AEs), deaths, or discontinuations due to an AE reported during the study. Teduglutide 4 mg/day for 10 days does not affect gastric emptying of liquids in healthy subjects as measured by acetaminophen pharmacokinetics. No unexpected safety signals were observed. This study was registered at ClinicalTrials.gov, identifier NCT01209351.

  19. A double-blind, randomized, multiple-dose, parallel-group study to characterize the occurrence of diarrhea following two different dosing regimens of neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor.

    Science.gov (United States)

    Abbas, Richat; Hug, Bruce A; Leister, Cathie; Sonnichsen, Daryl

    2012-07-01

    Neratinib, a potent, low-molecular-weight, orally administered, irreversible, pan-ErbB receptor tyrosine kinase inhibitor has antitumor activity in ErbB2 + breast cancer. The objective of this study was to characterize the onset, severity, and duration of diarrhea after administration of neratinib 240 mg once daily (QD) and 120 mg twice daily (BID) for ≤14 days in healthy subjects. A randomized, double-blind, parallel-group, inpatient study was conducted in 50 subjects given oral neratinib either 240 mg QD or 120 mg BID with food for ≤14 days. The primary endpoint was the proportion of subjects with diarrhea of at least moderate severity (grade 2; 5-7 loose stools/day). In subjects with grade 2 diarrhea, fecal analytes were determined. Pharmacokinetic profiles were characterized for neratinib on Days 1 and 7. No severe (grade 3) diarrhea was reported. By Day 4, all subjects had grade 1 diarrhea. Grade 2 diarrhea occurred in 11/22 evaluable subjects (50 % [90 % confidence interval (CI): 28-72 %]) in the QD group and 17/23 evaluable subjects (74 % [90 % CI: 52-90 %]) in the BID group (P = 0.130). In fecal analyses, 18 % tested positive for hemoglobin and 46 % revealed fecal lactoferrin. Specimen pH was neutral to slightly alkaline. In pharmacokinetic analyses, Day 1 peak plasma concentration and Day 7 steady-state exposure were higher with the QD regimen than the BID regimen. In an exploratory analysis, ABCG2 genotype showed no correlation with severity or onset of diarrhea. Incidences and onsets of at least grade 1 and at least grade 2 diarrhea were not improved on BID dosing compared with QD dosing.

  20. A phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of etelcalcetide (ONO-5163/AMG 416), a novel intravenous calcimimetic, for secondary hyperparathyroidism in Japanese haemodialysis patients.

    Science.gov (United States)

    Fukagawa, Masafumi; Yokoyama, Keitaro; Shigematsu, Takashi; Akiba, Takashi; Fujii, Akifumi; Kuramoto, Takuto; Odani, Motoi; Akizawa, Tadao

    2017-10-01

    Secondary hyperparathyroidism (SHPT) is a major complication associated with chronic kidney disease. We evaluated the efficacy and safety of etelcalcetide (ONO-5163/AMG 416), a novel intravenous calcimimetic, in Japanese haemodialysis patients with SHPT. In this phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study, etelcalcetide was administered three times per week at an initial dose of 5 mg, and subsequently adjusted to doses between 2.5 and 15 mg at 4-week intervals for 12 weeks. A total of 155 SHPT patients with serum intact parathyroid hormone (iPTH) levels ≥300 pg/mL were assigned to receive etelcalcetide (n = 78) or placebo (n = 77). The primary endpoint was the proportion of patients with decreased serum iPTH to the target range proposed by the Japanese Society for Dialysis Therapy (60-240 pg/mL). The major secondary endpoint was the proportion of patients with ≥30% reductions in serum iPTH from baseline. The proportion of patients meeting the primary endpoint was significantly higher for etelcalcetide (59.0%) versus placebo (1.3%). Similarly, the proportion of patients meeting the major secondary endpoint was significantly higher for etelcalcetide (76.9%) versus placebo (5.2%). Serum albumin-corrected calcium, phosphorus and intact fibroblast growth factor-23 levels were decreased in the etelcalcetide group. Nausea, vomiting and symptomatic hypocalcaemia were mild with etelcalcetide. Serious adverse events related to etelcalcetide were not observed. This study demonstrated the efficacy and safety of etelcalcetide. As the only available intravenous calcium-sensing receptor agonist, etelcalcetide is likely to provide a new treatment option for SHPT in haemodialysis patients. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA.

  1. Explicit symplectic integrators of molecular dynamics algorithms for rigid-body molecules in the canonical, isobaric-isothermal, and related ensembles.

    Science.gov (United States)

    Okumura, Hisashi; Itoh, Satoru G; Okamoto, Yuko

    2007-02-28

    The authors propose explicit symplectic integrators of molecular dynamics (MD) algorithms for rigid-body molecules in the canonical and isobaric-isothermal ensembles. They also present a symplectic algorithm in the constant normal pressure and lateral surface area ensemble and that combined with the Parrinello-Rahman algorithm. Employing the symplectic integrators for MD algorithms, there is a conserved quantity which is close to Hamiltonian. Therefore, they can perform a MD simulation more stably than by conventional nonsymplectic algorithms. They applied this algorithm to a TIP3P pure water system at 300 K and compared the time evolution of the Hamiltonian with those by the nonsymplectic algorithms. They found that the Hamiltonian was conserved well by the symplectic algorithm even for a time step of 4 fs. This time step is longer than typical values of 0.5-2 fs which are used by the conventional nonsymplectic algorithms.

  2. Parallel R

    CERN Document Server

    McCallum, Ethan

    2011-01-01

    It's tough to argue with R as a high-quality, cross-platform, open source statistical software product-unless you're in the business of crunching Big Data. This concise book introduces you to several strategies for using R to analyze large datasets. You'll learn the basics of Snow, Multicore, Parallel, and some Hadoop-related tools, including how to find them, how to use them, when they work well, and when they don't. With these packages, you can overcome R's single-threaded nature by spreading work across multiple CPUs, or offloading work to multiple machines to address R's memory barrier.

  3. Parallel Lines

    Directory of Open Access Journals (Sweden)

    James G. Worner

    2017-05-01

    Full Text Available James Worner is an Australian-based writer and scholar currently pursuing a PhD at the University of Technology Sydney. His research seeks to expose masculinities lost in the shadow of Australia’s Anzac hegemony while exploring new opportunities for contemporary historiography. He is the recipient of the Doctoral Scholarship in Historical Consciousness at the university’s Australian Centre of Public History and will be hosted by the University of Bologna during 2017 on a doctoral research writing scholarship.   ‘Parallel Lines’ is one of a collection of stories, The Shapes of Us, exploring liminal spaces of modern life: class, gender, sexuality, race, religion and education. It looks at lives, like lines, that do not meet but which travel in proximity, simultaneously attracted and repelled. James’ short stories have been published in various journals and anthologies.

  4. Expansions with respect to squares, symplectic and Poisson structures associated with the Sturm-Liouville problem. II

    International Nuclear Information System (INIS)

    Arkad'ev, V.A.; Pogrebkov, A.K.; Polivanov, M.K.

    1988-01-01

    The concept of tangent vector is made more precise to meet the specific nature of the Sturm-Liouville problem, and on this basis a Poisson bracket that is modified compared with the Gardner form by special boundary terms is derived from the Zakharov-Faddeev symplectic form. This bracket is nondegenerate, and in it the variables of the discrete and continuous spectra are separated

  5. A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face.

    Science.gov (United States)

    Gupta, Aditya K; Lynde, Charles W; Kunynetz, Rod A W; Amin, Smita; Choi, Ken; Goldstein, Eric

    2003-01-01

    Combination treatments for acne vulgaris, such as Benzamycin (3% erythromycin/5% benzoyl peroxide) and Stievamycin (0.025% tretinoin/erythromycin 4%), reduce bacterial growth, which contributes to the inflammatory lesions typical of adolescent acne, and also decrease the epidermal cell compaction which may form the characteristic noninflammatory comedone. Both agents contain erythromycin to reduce the growth of Propionibacterium acnes in skin. Benzoyl peroxide has antibiotic activity as well as anticomedogenic properties. Tretinoin may increase the turnover of epidermal cells and loosen the cells compacted to form comedones. A combination preparation containing the two antibiotics may reduce the development of resistance; the combination preparation containing tretinoin and erythromycin will have an antibiotic effect as well as acting on differentiation. This multicenter, randomized, double-blind, parallel group study compared the effectiveness of 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4%, each applied twice daily in patients with moderate acne vulgaris. Overall physician and patient ratings of severity of acne symptoms were performed at baseline and at weeks 2, 4, 8, and 12. At baseline the two treatment groups had similar disease severity. The number of papules, pustules, and comedones was reduced in both treatment groups at week 12, and the reductions were not significantly different between the two comparators. Global physician rating of improvement was significantly higher in the 3% erythromycin/5% benzoyl peroxide group compared with the 0.025% tretinoin/erythromycin 4% group; however, there was no significant difference in global patient ratings between the two treatment groups. An aggregate score was produced, for both physician rating and patient rating, by adding up individual symptom severity ratings. Compared with 0.025% tretinoin/erythromycin 4%, 3% erythromycin/5% benzoyl peroxide provided significantly greater reduction

  6. A two-site, two-arm, 34-week, double-blind, parallel-group, randomized controlled trial of reduced nicotine cigarettes in smokers with mood and/or anxiety disorders: trial design and protocol

    Directory of Open Access Journals (Sweden)

    Sophia I. Allen

    2017-01-01

    Full Text Available Abstract Background The U.S. Food and Drug Administration can set standards for cigarettes that could include reducing their nicotine content. Such a standard should improve public health without causing unintended serious consequences for sub-populations. This study evaluates the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxicant exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders using a two-site, two-arm, double-blind, parallel group, randomized controlled trial (RCT in four phases over 34 weeks. Methods Adult smokers (N = 200 of 5 or more cigarettes per day will be randomized across two sites (Penn State and Massachusetts General. Participants must have not had a quit attempt in the prior month, nor be planning to quit in the next 6 months, meet criteria for a current or lifetime unipolar mood and/or anxiety disorder based on the structured Mini-International Neuropsychiatric Interview, and must not have an unstable medical or psychiatric condition. After a week of smoking their own cigarettes, participants receive two weeks of Spectrum research cigarettes with usual nicotine content (11.6 mg. After this baseline period, participants will be randomly assigned to continue smoking Spectrum research cigarettes that contain either (a Usual Nicotine Content (11.6 mg; or (b Reduced Nicotine Content: the nicotine content per cigarette is progressively reduced from approximately 11.6 mg to 0.2 mg in five steps over 18 weeks. At the end of the randomization phase, participants will be offered the choice to either (a quit smoking with assistance, (b continue smoking free research cigarettes, or (c return to purchasing their own cigarettes, for the final 12 weeks of the study. The primary outcome measure is blood cotinine; key secondary outcomes are: exhaled carbon monoxide, urinary total NNAL- 4-(methylnitrosamino-1-(3-pyridyl-1-butanol and 1-hydroxypyrene, oxidative

  7. Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS: A prospective, randomized, double-blind, parallel group study

    Directory of Open Access Journals (Sweden)

    Chacon Pilar

    2011-04-01

    Full Text Available Abstract Background The use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. The type and quantity of the lipid emulsions used could modulate this response, which is mediated by the eicosanoids. This study investigates the use of omega-3 fatty acid-enriched lipid emulsions in ARDS patients and their effects on eicosanoid values. Methods Prospective, randomized, double-blind, parallel group study carried out at the Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain. We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men; age: 58 ± 13 years; APACHE II score 17.8 ± 2.3; Lung Injury Score: 3.1 ± 0.5; baseline PaO2/FiO2 ratio: 149 ± 40. Patients were randomized into two groups: Group A (n = 8 received the study emulsion Lipoplus® 20%, B. Braun Medical (50% MCT, 40% LCT, 10% fish oil (FO; Group B (n = 8 received the control emulsion Intralipid® Fresenius Kabi (100% LCT. Lipid emulsions were administered for 12 h at a dose of 0.12 g/kg/h. We measured LTB4, TXB2, and 6-keto prostaglandin F1α values at baseline [immediately before the administration of the lipid emulsions (T-0], at the end of the administration (T-12 and 24 hours after the beginning of the infusion (T 24 in arterial and mixed venous blood samples. Results In group A (FO LTB4, TXB2, 6-keto prostaglandin F1α levels fell during omega-3 administration (T12. After discontinuation (T24, levels of inflammatory markers (both systemic and pulmonary behaved erratically. In group B (LCT all systemic and pulmonary mediators increased during lipid administration and returned to baseline levels after discontinuation, but the differences did not reach statistical significance. There was a clear interaction between the treatment in group A (fish oil and changes in LTB4 over time. Conclusions Infusion of

  8. A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain.

    Science.gov (United States)

    Lee, Jae Hyup; Lee, Chong-Suh

    2013-11-01

    Chronic low back pain is a common condition that is often difficult to treat. The combination of tramadol hydrochloride and acetaminophen in an extended-release formulation has been shown to provide rapid and long-lasting analgesic effects resulting from the synergistic activity of these 2 active ingredients. The goal of this study was to evaluate the efficacy and safety of extended-release tramadol hydrochloride 75-mg/acetaminophen 650-mg fixed-dose combination tablets (TA-ER) for the treatment of chronic low back pain. This Phase III, double-blind, placebo-controlled, parallel-group study enrolled 245 patients with moderate to severe (≥4 cm on a 10-cm visual analog scale) chronic (≥3 months') low back pain insufficiently controlled by previous NSAIDs or cyclooxygenase-2-selective inhibitors and randomly assigned them to receive 4 weeks of either TA-ER or placebo. The primary efficacy end point was the percentage of patients with a pain intensity change rate ≥30% from baseline to final evaluation. Secondary end points included quality of life (Korean Short Form-36), functionality (Korean Oswestry Disability Index), and adverse events. The percentage of patients with a pain intensity change rate ≥30% was significantly higher (P Pain relief success rate from baseline was significantly higher with TA-ER versus placebo at days 8 and 15 but not at the final visit. Patients in the TA-ER group had significant improvements versus placebo in role-physical, general health, and reported health transition domains of the Korean Short Form-36 and significantly higher functional improvements in the personal care section of the Korean Oswestry Disability Index. Patient assessment of overall pain control as "very good" was also significantly higher with TA-ER than with placebo. Adverse events were reported more frequently with TA-ER than with placebo; the most common adverse events reported were nausea, dizziness, constipation, and vomiting. TA-ER was significantly more

  9. Phase 1, randomized, parallel-group, double-blind, placebo-controlled trial to evaluate the effects of erenumab (AMG 334) and concomitant sumatriptan on blood pressure in healthy volunteers.

    Science.gov (United States)

    de Hoon, Jan; Van Hecken, Anne; Vandermeulen, Corinne; Herbots, Marissa; Kubo, Yumi; Lee, Ed; Eisele, Osa; Vargas, Gabriel; Gabriel, Kristin

    2018-01-01

    Objectives The aim of this study was to assess the effects of concomitant administration of erenumab and sumatriptan on resting blood pressure, pharmacokinetics, safety, and tolerability in healthy subjects. Methods In this phase 1, parallel-group, one-way crossover, double-blind, placebo-controlled study, healthy adult subjects were randomized (1:2) to receive either intravenous placebo and subcutaneous sumatriptan 12 mg (i.e. two 6-mg injections separated by 1 hour) or intravenous erenumab 140 mg and subcutaneous sumatriptan 12 mg. Blood pressure was measured pre-dose and at prespecified times post-dose. The primary endpoint was individual time-weighted averages of mean arterial pressure, measured from 0 hours to 2.5 hours after the first dose of sumatriptan. Pharmacokinetic parameters for sumatriptan were evaluated by calculating geometric mean ratios (erenumab and sumatriptan/placebo and sumatriptan). Adverse events and anti-erenumab antibodies were also evaluated. Results A total of 34 subjects were randomized and included in the analysis. Least squares mean (standard error) time-weighted averages of mean arterial pressure were 87.4 (1.0) mmHg for the placebo and sumatriptan group and 87.4 (1.2) mmHg for the erenumab and sumatriptan group. Mean difference in mean arterial pressure between groups was -0.04 mmHg (90% confidence interval: -2.2, 2.1). Geometric mean ratio estimates for maximum plasma concentration of sumatriptan was 0.95 (90% confidence interval: 0.82, 1.09), area under the plasma concentration-time curve (AUC) from time 0 to 6 hours was 0.98 (90% confidence interval: 0.93, 1.03), and AUC from time 0 to infinity was 1.00 (90% confidence interval: 0.96, 1.05). No clinically relevant safety findings for co-administration of sumatriptan and erenumab were identified. Conclusion Co-administration of erenumab and sumatriptan had no additional effect on resting blood pressure or on pharmacokinetics of sumatriptan. ClinicalTrials.gov, NCT

  10. A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study.

    Science.gov (United States)

    Park, Won; Hrycaj, Pawel; Jeka, Slawomir; Kovalenko, Volodymyr; Lysenko, Grygorii; Miranda, Pedro; Mikazane, Helena; Gutierrez-Ureña, Sergio; Lim, MieJin; Lee, Yeon-Ah; Lee, Sang Joon; Kim, HoUng; Yoo, Dae Hyun; Braun, Jürgen

    2013-10-01

    To compare the pharmacokinetics (PK), safety and efficacy of innovator infliximab (INX) and CT-P13, a biosimilar to INX, in patients with active ankylosing spondylitis (AS). Phase 1 randomised, double-blind, multicentre, multinational, parallel-group study. Patients were randomised to receive 5 mg/kg of CT-P13 (n=125) or INX (n=125). Primary endpoints were area under the concentration-time curve (AUC) at steady state and observed maximum steady state serum concentration (Cmax,ss) between weeks 22 and 30. Additional PK, efficacy endpoints, including 20% and 40% improvement response according to Assessment in Ankylosing Spondylitis International Working Group criteria (ASAS20 and ASAS40), and safety outcomes were also assessed. Geometric mean AUC was 32 765.8 μgh/ml for CT-P13 and 31 359.3 μgh/ml for INX. Geometric mean Cmax,ss was 147.0 μg/ml for CT-P13 and 144.8 μg/ml for INX. The ratio of geometric means was 104.5% (90% CI 94% to 116%) for AUC and 101.5% (90% CI 95% to 109%) for Cmax,ss. ASAS20 and ASAS40 responses at week 30 were 70.5% and 51.8% for CT-P13 and 72.4% and 47.4% for INX, respectively. In the CT-P13 and INX groups more than one adverse event occurred in 64.8% and 63.9% of patients, infusion reactions occurred in 3.9% and 4.9%, active tuberculosis occurred in 1.6% and 0.8%, and 27.4% and 22.5% of patients tested positive for anti-drug antibodies, respectively. The PK profiles of CT-P13 and INX were equivalent in patients with active AS. CT-P13 was well tolerated, with an efficacy and safety profile comparable to that of INX up to week 30.

  11. Section sigma models coupled to symplectic duality bundles on Lorentzian four-manifolds

    Science.gov (United States)

    Lazaroiu, C. I.; Shahbazi, C. S.

    2018-06-01

    We give the global mathematical formulation of a class of generalized four-dimensional theories of gravity coupled to scalar matter and to Abelian gauge fields. In such theories, the scalar fields are described by a section of a surjective pseudo-Riemannian submersion π over space-time, whose total space carries a Lorentzian metric making the fibers into totally-geodesic connected Riemannian submanifolds. In particular, π is a fiber bundle endowed with a complete Ehresmann connection whose transport acts through isometries between the fibers. In turn, the Abelian gauge fields are "twisted" by a flat symplectic vector bundle defined over the total space of π. This vector bundle is endowed with a vertical taming which locally encodes the gauge couplings and theta angles of the theory and gives rise to the notion of twisted self-duality, of crucial importance to construct the theory. When the Ehresmann connection of π is integrable, we show that our theories are locally equivalent to ordinary Einstein-Scalar-Maxwell theories and hence provide a global non-trivial extension of the universal bosonic sector of four-dimensional supergravity. In this case, we show using a special trivializing atlas of π that global solutions of such models can be interpreted as classical "locally-geometric" U-folds. In the non-integrable case, our theories differ locally from ordinary Einstein-Scalar-Maxwell theories and may provide a geometric description of classical U-folds which are "locally non-geometric".

  12. A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE).

    Science.gov (United States)

    Allen, S J; Wareham, K; Wang, D; Bradley, C; Sewell, B; Hutchings, H; Harris, W; Dhar, A; Brown, H; Foden, A; Gravenor, M B; Mack, D; Phillips, C J

    2013-12-01

    Antibiotic-associated diarrhoea (AAD) occurs most commonly in older people admitted to hospital and within 12 weeks of exposure to broad-spectrum antibiotics. Although usually a mild and self-limiting illness, the 15-39% of cases caused by Clostridium difficile infection [C. difficile diarrhoea (CDD)] may result in severe diarrhoea and death. Previous research has shown that probiotics, live microbial organisms that, when administered in adequate numbers, are beneficial to health, may be effective in preventing AAD and CDD. To determine the clinical effectiveness and cost-effectiveness of a high-dose, multistrain probiotic in the prevention of AAD and CDD in older people admitted to hospital. A multicentre, randomised, double-blind, placebo-controlled, parallel-arm trial. Medical, surgical and elderly care inpatient wards in five NHS hospitals in the UK. Eligible patients were aged ≥ 65 years, were exposed to one or more oral or parenteral antibiotics and were without pre-existing diarrhoeal disorders, recent CDD or at risk of probiotic adverse effects. Out of 17,420 patients screened, 2981 (17.1%) were recruited. Participants were allocated sequentially according to a computer-generated random allocation sequence; 1493 (50.1%) were allocated to the probiotic and 1488 (49.9%) to the placebo arm. Vegetarian capsules containing two strains of lactobacilli and two strains of bifidobacteria (a total of 6 × 10(10) organisms per day) were taken daily for 21 days. The placebo was inert maltodextrin powder in identical capsules. The occurrence of AAD within 8 weeks and CDD within 12 weeks of recruitment was determined by participant follow-up and checking hospital laboratory records by research nurses who were blind to arm allocation. Analysis based on the treatment allocated included 2941 (98.7%) participants. Potential risk factors for AAD at baseline were similar in the two study arms. Frequency of AAD (including CDD) was similar in the probiotic (159/1470, 10

  13. Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

    Science.gov (United States)

    Ludolph, Albert C; Schuster, Joachim; Dorst, Johannes; Dupuis, Luc; Dreyhaupt, Jens; Weishaupt, Jochen H; Kassubek, Jan; Weiland, Ulrike; Petri, Susanne; Meyer, Thomas; Grosskreutz, Julian; Schrank, Berthold; Boentert, Matthias; Emmer, Alexander; Hermann, Andreas; Zeller, Daniel; Prudlo, Johannes; Winkler, Andrea S; Grehl, Torsten; Heneka, Michael T; Wollebæk Johannesen, Siw; Göricke, Bettina

    2018-06-18

    Rasagiline, a monoamine oxidase B inhibitor with neuroprotective potential in Parkinson's disease, has shown a disease-modifying effect in the SOD1-Gly93Ala low-expressing mouse model of amyotrophic lateral sclerosis, both alone and in combination with riluzole. We sought to test whether or not rasagiline 1 mg/day can prolong survival in patients with amyotrophic lateral sclerosis also receiving riluzole. Patients with possible, probable, or definite amyotrophic lateral sclerosis were enrolled to our randomised, placebo-controlled, parallel-group, double-blind, phase 2 trial from 15 German network for motor neuron diseases (MND-NET) centres (university hospitals or clinics). Eligible patients were aged at least 18 years, had onset of progressive weakness within the 36 months before the study, had disease duration of more than 6 months and less than 3 years, and had a best-sitting slow vital capacity of at least 50%. After a 4-week screening period, eligible patients were randomly assigned (1:1) to receive either rasagiline (1 mg/day) or placebo in addition to riluzole (100 mg/day), after stratification for site of onset (bulbar or spinal) and study centre. Patients and all personnel assessing outcome parameters were masked to treatment allocation. Patients were followed up 2, 6, 12, and 18 months after randomisation. The primary endpoint was survival time, defined as the time to death or time to study cutoff date (ie, the last patient's last visit plus 14 days). Analyses of primary outcome and safety measures were done in all patients who received at least one dose of trial treatment (intention-to-treat population). The trial is registered with ClinicalTrials.gov, number NCT01879241. Between July 2, 2013, and Nov 11, 2014, 273 patients were screened for eligibility, and 252 patients were randomly assigned to receive rasagiline (n=127) or placebo (n=125). 126 patients taking rasagiline and 125 taking placebo were included in the intention-to-treat analysis. For the

  14. Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular hospitalization or death from any cause in PatiENts with atrial fibrillation/atrial flutter

    DEFF Research Database (Denmark)

    Hohnloser, S.H.; Connolly, S.J.; Crijns, H.J.G.M.

    2008-01-01

    hospitalization or death from any cause. The study has completed patient enrollment in December 2006 and is expected to end follow-up 1 year later. Conclusion: ATHENA will be the largest efficacy and safety trial of dronedarone, a multichannel blocker compound with properties from class I, II, III, and IV....... Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF. Methods: The ATHENA trial (A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in pati...

  15. Modeling of stochastic broadening in a poloidally diverted discharge with piecewise analytic symplectic mapping flux functions

    International Nuclear Information System (INIS)

    Punjabi, Alkesh; Ali, Halima; Evans, Todd; Boozer, Allen

    2008-01-01

    A highly accurate calculation of the magnetic field line Hamiltonian in DIII-D [J. L. Luxon and L. E. Davis, Fusion Technol. 8, 441 (1985)] is made from piecewise analytic equilibrium fit data for shot 115467 3000 ms. The safety factor calculated from this Hamiltonian has a logarithmic singularity at an ideal separatrix. The logarithmic region inside the ideal separatrix contains 2.5% of toroidal flux inside the separatrix. The logarithmic region is symmetric about the separatrix. An area-preserving map for the field line trajectories is obtained in magnetic coordinates from the Hamiltonian equations of motion for the lines and a canonical transformation. This map is used to calculate trajectories of magnetic field lines in DIII-D. The field line Hamiltonian in DIII-D is used as the generating function for the map and to calculate stochastic broadening from field-errors and spatial noise near the separatrix. A very negligible amount (0.03%) of magnetic flux is lost from inside the separatrix due to these nonaxisymmetric fields. It is quite easy to add magnetic perturbations to generating functions and calculate trajectories for maps in magnetic coordinates. However, it is not possible to integrate across the separatrix. It is also difficult to find the physical position corresponding to magnetic coordinates. For open field lines, periodicity in the poloidal angle is assumed, which is not satisfactory. The goal of this paper is to demonstrate the efficacy of the symplectic mapping approach rather than using realistic DIII-D parameters or modeling specific experimental results

  16. On the physics of relativistic double layers

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-06-01

    A model of a strong, time-independent, and relativistic double layer is studied. Besides double layers having the electric field parallel to the current the model also describes a certain type of oblique double layers. The 'Langmuir condition' (ratio of ion current density to electron current density) as well as an expression for the potential drop of the double layer are derived. Furthermore, the distribution of charged particles, electric field, and potential within the double layer are clarified and discussed. It is found that the properties of relativistic double layers differ substantially from the properties of corresponding non-relativistic double layers. (Author)

  17. High order three part split symplectic integrators: Efficient techniques for the long time simulation of the disordered discrete nonlinear Schrödinger equation

    Energy Technology Data Exchange (ETDEWEB)

    Skokos, Ch., E-mail: haris.skokos@uct.ac.za [Physics Department, Aristotle University of Thessaloniki, GR-54124 Thessaloniki (Greece); Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch 7701 (South Africa); Gerlach, E. [Lohrmann Observatory, Technical University Dresden, D-01062 Dresden (Germany); Bodyfelt, J.D., E-mail: J.Bodyfelt@massey.ac.nz [Centre for Theoretical Chemistry and Physics, The New Zealand Institute for Advanced Study, Massey University, Albany, Private Bag 102904, North Shore City, Auckland 0745 (New Zealand); Papamikos, G. [School of Mathematics, Statistics and Actuarial Science, University of Kent, Canterbury, CT2 7NF (United Kingdom); Eggl, S. [IMCCE, Observatoire de Paris, 77 Avenue Denfert-Rochereau, F-75014 Paris (France)

    2014-05-01

    While symplectic integration methods based on operator splitting are well established in many branches of science, high order methods for Hamiltonian systems that split in more than two parts have not been studied in great detail. Here, we present several high order symplectic integrators for Hamiltonian systems that can be split in exactly three integrable parts. We apply these techniques, as a practical case, for the integration of the disordered, discrete nonlinear Schrödinger equation (DDNLS) and compare their efficiencies. Three part split algorithms provide effective means to numerically study the asymptotic behavior of wave packet spreading in the DDNLS – a hotly debated subject in current scientific literature.

  18. High order three part split symplectic integrators: Efficient techniques for the long time simulation of the disordered discrete nonlinear Schrödinger equation

    International Nuclear Information System (INIS)

    Skokos, Ch.; Gerlach, E.; Bodyfelt, J.D.; Papamikos, G.; Eggl, S.

    2014-01-01

    While symplectic integration methods based on operator splitting are well established in many branches of science, high order methods for Hamiltonian systems that split in more than two parts have not been studied in great detail. Here, we present several high order symplectic integrators for Hamiltonian systems that can be split in exactly three integrable parts. We apply these techniques, as a practical case, for the integration of the disordered, discrete nonlinear Schrödinger equation (DDNLS) and compare their efficiencies. Three part split algorithms provide effective means to numerically study the asymptotic behavior of wave packet spreading in the DDNLS – a hotly debated subject in current scientific literature.

  19. Fermion analogy for layered superconducting films in parallel magnetic field

    International Nuclear Information System (INIS)

    Rodriguez, J.P.

    1997-01-01

    The equivalence between the Lawrence-Doniach model for films of extreme type-II layered superconductors and a generalization of the back-scattering model for spin-(1/2) electrons in one dimension is demonstrated. This fermion analogy is then exploited to obtain an anomalous H parallel -1 tail for the parallel equilibrium magnetization of the minimal double-layer case in the limit of high parallel magnetic fields H parallel for temperatures in the critical regime. (orig.)

  20. Alternative derivation of the parallel ion viscosity

    International Nuclear Information System (INIS)

    Bravenec, R.V.; Berk, H.L.; Hammer, J.H.

    1982-01-01

    A set of double-adiabatic fluid equations with additional collisional relaxation between the ion temperatures parallel and perpendicular to a magnetic field are shown to reduce to a set involving a single temperature and a parallel viscosity. This result is applied to a recently published paper [R. V. Bravenec, A. J. Lichtenberg, M. A. Leiberman, and H. L. Berk, Phys. Fluids 24, 1320 (1981)] on viscous flow in a multiple-mirror configuration

  1. Seiberg-Witten curves and double-elliptic integrable systems

    International Nuclear Information System (INIS)

    Aminov, G.; Braden, H.W.; Mironov, A.; Morozov, A.; Zotov, A.

    2015-01-01

    An old conjecture claims that commuting Hamiltonians of the double-elliptic integrable system are constructed from the theta-functions associated with Riemann surfaces from the Seiberg-Witten family, with moduli treated as dynamical variables and the Seiberg-Witten differential providing the pre-symplectic structure. We describe a number of theta-constant equations needed to prove this conjecture for the N-particle system. These equations provide an alternative method to derive the Seiberg-Witten prepotential and we illustrate this by calculating the perturbative contribution. We provide evidence that the solutions to the commutativity equations are exhausted by the double-elliptic system and its degenerations (Calogero and Ruijsenaars systems). Further, the theta-function identities that lie behind the Poisson commutativity of the three-particle Hamiltonians are proven.

  2. Object-Oriented Parallel Particle-in-Cell Code for Beam Dynamics Simulation in Linear Accelerators

    International Nuclear Information System (INIS)

    Qiang, J.; Ryne, R.D.; Habib, S.; Decky, V.

    1999-01-01

    In this paper, we present an object-oriented three-dimensional parallel particle-in-cell code for beam dynamics simulation in linear accelerators. A two-dimensional parallel domain decomposition approach is employed within a message passing programming paradigm along with a dynamic load balancing. Implementing object-oriented software design provides the code with better maintainability, reusability, and extensibility compared with conventional structure based code. This also helps to encapsulate the details of communications syntax. Performance tests on SGI/Cray T3E-900 and SGI Origin 2000 machines show good scalability of the object-oriented code. Some important features of this code also include employing symplectic integration with linear maps of external focusing elements and using z as the independent variable, typical in accelerators. A successful application was done to simulate beam transport through three superconducting sections in the APT linac design

  3. Parallel Programming with Intel Parallel Studio XE

    CERN Document Server

    Blair-Chappell , Stephen

    2012-01-01

    Optimize code for multi-core processors with Intel's Parallel Studio Parallel programming is rapidly becoming a "must-know" skill for developers. Yet, where to start? This teach-yourself tutorial is an ideal starting point for developers who already know Windows C and C++ and are eager to add parallelism to their code. With a focus on applying tools, techniques, and language extensions to implement parallelism, this essential resource teaches you how to write programs for multicore and leverage the power of multicore in your programs. Sharing hands-on case studies and real-world examples, the

  4. Analysis of stroke in ATHENA: a placebo-controlled, double-blind, parallel-arm trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation/atrial flutter

    DEFF Research Database (Denmark)

    Connolly, Stuart J; Crijns, Harry J G M; Torp-Pedersen, Christian

    2009-01-01

    , on stroke has been evaluated in a randomized, double-blind clinical trial, ATHENA (A placebo-controlled, double-blind, parallel-arm Trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation....../atrial flutter). METHODS AND RESULTS: Patients with persistent or paroxysmal atrial fibrillation and at least 1 risk factor for cardiovascular hospitalization were randomized to receive dronedarone (400 mg BID) or double-blind matching placebo and followed up for a minimum of 1 year to a common termination at 30...... of either oral anticoagulant therapy or antiplatelet agent alone was 60%. Dronedarone reduced the risk of stroke from 1.8% per year to 1.2% per year (hazard ratio 0.66, 95% confidence interval 0.46 to 0.96, P=0.027). The effect of dronedarone was similar whether or not patients were receiving oral...

  5. Practical parallel computing

    CERN Document Server

    Morse, H Stephen

    1994-01-01

    Practical Parallel Computing provides information pertinent to the fundamental aspects of high-performance parallel processing. This book discusses the development of parallel applications on a variety of equipment.Organized into three parts encompassing 12 chapters, this book begins with an overview of the technology trends that converge to favor massively parallel hardware over traditional mainframes and vector machines. This text then gives a tutorial introduction to parallel hardware architectures. Other chapters provide worked-out examples of programs using several parallel languages. Thi

  6. Parallel sorting algorithms

    CERN Document Server

    Akl, Selim G

    1985-01-01

    Parallel Sorting Algorithms explains how to use parallel algorithms to sort a sequence of items on a variety of parallel computers. The book reviews the sorting problem, the parallel models of computation, parallel algorithms, and the lower bounds on the parallel sorting problems. The text also presents twenty different algorithms, such as linear arrays, mesh-connected computers, cube-connected computers. Another example where algorithm can be applied is on the shared-memory SIMD (single instruction stream multiple data stream) computers in which the whole sequence to be sorted can fit in the

  7. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms

    OpenAIRE

    Feldman Samantha; Alvarez Patricia; Schwartz Howard I; Kalman Douglas S; Pezzullo John C; Krieger Diane R

    2009-01-01

    Abstract Background This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence) but no gastrointestinal (GI) diagnoses to explain the symptoms. Methods Sixty-one adults were enrolled (age 36.5 ± 12.6 years; height 165.1 ± 9.2 cm; weight 75.4 ± 17.3 kg) and randomized to either Digest...

  8. Introduction to parallel programming

    CERN Document Server

    Brawer, Steven

    1989-01-01

    Introduction to Parallel Programming focuses on the techniques, processes, methodologies, and approaches involved in parallel programming. The book first offers information on Fortran, hardware and operating system models, and processes, shared memory, and simple parallel programs. Discussions focus on processes and processors, joining processes, shared memory, time-sharing with multiple processors, hardware, loops, passing arguments in function/subroutine calls, program structure, and arithmetic expressions. The text then elaborates on basic parallel programming techniques, barriers and race

  9. Parallel computing works!

    CERN Document Server

    Fox, Geoffrey C; Messina, Guiseppe C

    2014-01-01

    A clear illustration of how parallel computers can be successfully appliedto large-scale scientific computations. This book demonstrates how avariety of applications in physics, biology, mathematics and other scienceswere implemented on real parallel computers to produce new scientificresults. It investigates issues of fine-grained parallelism relevant forfuture supercomputers with particular emphasis on hypercube architecture. The authors describe how they used an experimental approach to configuredifferent massively parallel machines, design and implement basic systemsoftware, and develop

  10. The Differential-Algebraic Analysis of Symplectic and Lax Structures Related with New Riemann-Type Hydrodynamic Systems

    Science.gov (United States)

    Prykarpatsky, Yarema A.; Artemovych, Orest D.; Pavlov, Maxim V.; Prykarpatski, Anatolij K.

    2013-06-01

    A differential-algebraic approach to studying the Lax-type integrability of the generalized Riemann-type hydrodynamic hierarchy, proposed recently by O. D. Artemovych, M. V. Pavlov, Z. Popowicz and A. K. Prykarpatski, is developed. In addition to the Lax-type representation, found before by Z. Popowicz, a closely related representation is constructed in exact form by means of a new differential-functional technique. The bi-Hamiltonian integrability and compatible Poisson structures of the generalized Riemann type hierarchy are analyzed by means of the symplectic and gradient-holonomic methods. An application of the devised differential-algebraic approach to other Riemann and Vakhnenko type hydrodynamic systems is presented.

  11. The symplectic fermion ribbon quasi-Hopf algebra and the SL(2,Z)-action on its centre

    Energy Technology Data Exchange (ETDEWEB)

    Farsad, Vanda

    2017-06-14

    This thesis is concerned with ''N pairs of symplectic fermions'' which are examples of logarithmic conformal field theories in two dimensions. The mathematical language of two-dimensional conformal field theories (on Riemannian surfaces of genus zero) are vertex operator algebras. The representation category of the even part of the symplectic fermion vertex operator super-algebra Rep V{sub ev} is conjecturally a factorisable finite ribbon tensor category. This determines an isomorphism of projective representations between two SL(2,Z)-actions associated to V{sub ev}. The first action is obtained by modular transformations on the space of so-called pseudo-trace functions of a vertex operator algebra. For V{sub ev} this was developed by A.M.Gaberdiel and I. Runkel. For the action one uses that Rep V{sub ev} is conjecturally a factorisable finite ribbon tensor category and thus carries a projective SL(2,Z)-action on a certain Hom-space [Ly1,Ly2,KL]. To do so we calculate the SL(2,Z)-action on the representation category of a general factorisable quasi-Hopf algebras. Then we show that Rep V{sub ev} is conjecturally ribbon equivalent to Rep Q, for Q a factorisable quasi-Hopf algebra, and calculate the SL(2,Z)-action explicitly on Rep Q. The result is that the two SL(2,Z)-action indeed agree. This poses the first example of such comparison for logarithmic conformal field theories.

  12. Post-hoc analysis of MCI186-17, the extension study to MCI186-16, the confirmatory double-blind, parallel-group, placebo-controlled study of edaravone in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Takahashi, Fumihiro; Takei, Koji; Tsuda, Kikumi; Palumbo, Joseph

    2017-10-01

    In the 24-week double-blind study of edaravone in ALS (MCI186-16), edaravone did not show a statistically significant difference versus placebo for the primary efficacy endpoint. For post-hoc analyses, two subpopulations were identified in which edaravone might be expected to show efficacy: the efficacy-expected subpopulation (EESP), defined by scores of ≥2 points on all 12 items of the ALS Functional Rating Scale-Revised (ALSFRS-R) and a percent predicted forced vital capacity (%FVC) ≥80% at baseline; and the definite/probable EESP 2 years (dpEESP2y) subpopulation which, in addition to EESP criteria, had definite or probable ALS diagnosed by El Escorial revised criteria, and disease duration of ≤2 years. In the 36-week extension study of MCI186-16, a 24-week double-blind comparison followed by 12 weeks of open-label edaravone (MCI186-17; NCT00424463), analyses of ALSFRS-R scores of the edaravone-edaravone group and edaravone-placebo group for the full analysis set (FAS) and EESP, as prospectively defined, were reported in a previous article. Here we additionally report results in patients who met dpEESP2y criteria at the baseline of MCI186-16. In the dpEESP2y, the difference in ALSFRS-R changes from 24 to 48 weeks between the edaravone-edaravone and edaravone-placebo groups was 2.79 (p = 0.0719), which was greater than the differences previously reported for the EESP and the FAS. The pattern of adverse events in the dpEESP2y did not show any additional safety findings to those from the earlier prospective study. In conclusion, this post-hoc analysis suggests a potential effect of edaravone between 24 and 48 weeks in patients meeting dpEESP2y criteria at baseline.

  13. Parallel Atomistic Simulations

    Energy Technology Data Exchange (ETDEWEB)

    HEFFELFINGER,GRANT S.

    2000-01-18

    Algorithms developed to enable the use of atomistic molecular simulation methods with parallel computers are reviewed. Methods appropriate for bonded as well as non-bonded (and charged) interactions are included. While strategies for obtaining parallel molecular simulations have been developed for the full variety of atomistic simulation methods, molecular dynamics and Monte Carlo have received the most attention. Three main types of parallel molecular dynamics simulations have been developed, the replicated data decomposition, the spatial decomposition, and the force decomposition. For Monte Carlo simulations, parallel algorithms have been developed which can be divided into two categories, those which require a modified Markov chain and those which do not. Parallel algorithms developed for other simulation methods such as Gibbs ensemble Monte Carlo, grand canonical molecular dynamics, and Monte Carlo methods for protein structure determination are also reviewed and issues such as how to measure parallel efficiency, especially in the case of parallel Monte Carlo algorithms with modified Markov chains are discussed.

  14. Doubled-ended ceramic thyratron

    CERN Multimedia

    1974-01-01

    The double-ended ceramic thyratron CX 1171 B, with its coaxial voltage divider for the SPS. Such a switch, paralleled by three ignitrons in series forms the "thyragnitron" arrangement, and can switch 10 kA, 25 ms pulses, with very fast rise times.

  15. Comparison in myelography between iodixanol 270 and 320 mgI/ml and iotrolan 300 mgI/ml: a multicentre, randomised, parallel-group, double-blind, phase III trial

    International Nuclear Information System (INIS)

    Palmers, Yvan; Kuhn, Fritz-Peter; Petersen, Dirk; De Greef, Danielle

    2002-01-01

    The objective of the trial was to compare the safety and efficacy of the non-ionic, dimeric, isotonic contrast medium iodixanol (Visipaque 270 and 320 mgI/ml) with those of iotrolan (Isovist 300 mgI/ml) in myelography. After lumbar or cervical puncture, 315 patients were examined in a multicentre, double-blind, randomised, comparative myelography study. Image quality, changes in vital signs, immediate and delayed adverse events were registered. There was a tendency for better images with iodixanol 320 than with iodixanol 270 and iotrolan 300, but the overall quality was good or excellent with all products. The frequency of patients reporting adverse events and headache varied much across centres, but there was no statistically significant difference between the contrast media. The incidence of events was higher after lumbar puncture than after cervical puncture, in women rather than in men, and after puncture with a 22-gauge (G) bevel-tipped needle compared with a 24 G Sprotte needle. The frequency of headache did not correlate with the absence of pathology. The higher iodine concentration in iodixanol 320 could be an advantage for film quality. When compared with iotrolan 300, iodixanol 320 and 270 give similar incidences of adverse events, including headache. (orig.)

  16. Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

    Science.gov (United States)

    Rascol, O; Brooks, D J; Melamed, E; Oertel, W; Poewe, W; Stocchi, F; Tolosa, E

    Rasagiline mesylate is a novel drug for Parkinson's disease with selective, irreversible monoamine oxidase B (MAO-B) inhibitor activity, and is effective as monotherapy in early disease. This study investigated rasagiline efficacy and safety in levodopa-treated patients with Parkinson's disease and motor fluctuations. In an 18-week, double-blind, multicentre (74 hospitals and academic centres in Israel, Argentina, and Europe) trial, 687 outpatients were randomly assigned to oral rasagiline (231 individuals; 1 mg once daily), entacapone (227; 200 mg with every levodopa dose), or placebo (229). Primary outcome was change in total daily off-time (intention-to-treat population). Other measures included the clinical global improvement (CGI) score and unified Parkinson's disease rating scale (UPDRS) scores. Analysis was by intention to treat. 88 (13%) patients who were assigned treatment did not complete the study (23 rasagiline, 30 entacapone, 35 placebo), mainly because of withdrawal of consent (n=34) and adverse events (n=34). Both rasagiline and entacapone reduced mean daily off-time (-1.18 h rasagiline and -1.2 h entacapone vs placebo -0.4 h; p=0.0001, prasagiline and -0.72 entacapone vs -0.37 placebo; prasagiline reduces mean daily off-time and improves symptoms of Parkinson's disease in levodopa-treated patients with motor fluctuations, an effect similar to that of entacapone.

  17. Effects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: a randomized, double-blind, parallel trial

    Science.gov (United States)

    Öztürk, T.; Ağdanlı, D.; Bayturan, Ö.; Çıkrıkcı, C.; Keleş, G.T.

    2015-01-01

    Myocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval (QTc) prolongation. The objective of this randomized, double-blind trial was to determine the effects of high- vs conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias following anesthesia induction and intubation. Fifty patients about to undergo coronary artery surgery were randomly allocated to receive conventional-dose (0.6 mg/kg, group C, n=25) or high-dose (1.2 mg/kg, group H, n=25) rocuronium after induction with etomidate and fentanyl. QTc, heart rate, and mean arterial pressure were recorded before induction (T0), after induction (T1), after rocuronium (just before laryngoscopy; T2), 2 min after intubation (T3), and 5 min after intubation (T4). The occurrence of dysrhythmias was recorded. In both groups, QTc was significantly longer at T3 than at baseline [475 vs 429 ms in group C (P=0.001), and 459 vs 434 ms in group H (P=0.005)]. The incidence of dysrhythmias in group C (28%) and in group H (24%) was similar. The QTc after high-dose rocuronium was not significantly longer than after conventional-dose rocuronium in patients about to undergo coronary artery surgery who were induced with etomidate and fentanyl. In both groups, compared with baseline, QTc was most prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to the nociceptive stimulus of intubation. PMID:25714880

  18. A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol.

    Science.gov (United States)

    Currow, David; Watts, Gareth John; Johnson, Miriam; McDonald, Christine F; Miners, John O; Somogyi, Andrew A; Denehy, Linda; McCaffrey, Nicola; Eckert, Danny J; McCloud, Philip; Louw, Sandra; Lam, Lawrence; Greene, Aine; Fazekas, Belinda; Clark, Katherine C; Fong, Kwun; Agar, Meera R; Joshi, Rohit; Kilbreath, Sharon; Ferreira, Diana; Ekström, Magnus

    2017-07-17

    Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended- release (ER) oral morphine. A recent large phase III study suggests the subgroup most likely to benefit have chronic obstructive pulmonary disease (COPD) and modified Medical Research Council breathlessness scores of 3 or 4. This protocol is for an adequately powered, parallel-arm, placebo-controlled, multisite, factorial, block-randomised study evaluating regular ER morphine for chronic breathlessness in people with COPD. The primary question is what effect regular ER morphine has on worst breathlessness, measured daily on a 0-10 numerical rating scale. Uniquely, the coprimary outcome will use a FitBit to measure habitual physical activity. Secondary questions include safety and, whether upward titration after initial benefit delivers greater net symptom reduction. Substudies include longitudinal driving simulation, sleep, caregiver, health economic and pharmacogenetic studies. Seventeen centres will recruit 171 participants from respiratory and palliative care. The study has five phases including three randomisation phases to increasing doses of ER morphine. All participants will receive placebo or active laxatives as appropriate. Appropriate statistical analysis of primary and secondary outcomes will be used. Ethics approval has been obtained. Results of the study will be submitted for publication in peer-reviewed journals, findings presented at relevant conferences and potentially used to inform registration of ER morphine for chronic breathlessness. NCT02720822; Pre-results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Double Trouble

    NARCIS (Netherlands)

    Elsaesser, Thomas; Kievit, Robert; Simons, Jan

    1994-01-01

    Double Trouble highlights the career of Dutch scriptwriter and television producer Chiem van Houweninge, well-known for his long-running TV comedy series and as author of episodes for TV detective series. Double Trouble gives Van Houweninge's own views on writing and filming in television prime

  20. Parallelization in Modern C++

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The traditionally used and well established parallel programming models OpenMP and MPI are both targeting lower level parallelism and are meant to be as language agnostic as possible. For a long time, those models were the only widely available portable options for developing parallel C++ applications beyond using plain threads. This has strongly limited the optimization capabilities of compilers, has inhibited extensibility and genericity, and has restricted the use of those models together with other, modern higher level abstractions introduced by the C++11 and C++14 standards. The recent revival of interest in the industry and wider community for the C++ language has also spurred a remarkable amount of standardization proposals and technical specifications being developed. Those efforts however have so far failed to build a vision on how to seamlessly integrate various types of parallelism, such as iterative parallel execution, task-based parallelism, asynchronous many-task execution flows, continuation s...

  1. Parallelism in matrix computations

    CERN Document Server

    Gallopoulos, Efstratios; Sameh, Ahmed H

    2016-01-01

    This book is primarily intended as a research monograph that could also be used in graduate courses for the design of parallel algorithms in matrix computations. It assumes general but not extensive knowledge of numerical linear algebra, parallel architectures, and parallel programming paradigms. The book consists of four parts: (I) Basics; (II) Dense and Special Matrix Computations; (III) Sparse Matrix Computations; and (IV) Matrix functions and characteristics. Part I deals with parallel programming paradigms and fundamental kernels, including reordering schemes for sparse matrices. Part II is devoted to dense matrix computations such as parallel algorithms for solving linear systems, linear least squares, the symmetric algebraic eigenvalue problem, and the singular-value decomposition. It also deals with the development of parallel algorithms for special linear systems such as banded ,Vandermonde ,Toeplitz ,and block Toeplitz systems. Part III addresses sparse matrix computations: (a) the development of pa...

  2. Long-term numerical simulation of the interaction between a neutron field and a neutral meson field by a symplectic-preserving scheme

    International Nuclear Information System (INIS)

    Kong Linghua; Hong Jialin; Liu Ruxun

    2008-01-01

    In this paper, we propose a family of symplectic structure-preserving numerical methods for the coupled Klein-Gordon-Schroedinger (KGS) system. The Hamiltonian formulation is constructed for the KGS. We discretize the Hamiltonian system in space first with a family of canonical difference methods which convert an infinite-dimensional Hamiltonian system into a finite-dimensional one. Next, we discretize the finite-dimensional system in time by a midpoint rule which preserves the symplectic structure of the original system. The conservation laws of the schemes are analyzed in succession, including the charge conservation law and the residual of energy conservation law, etc. We analyze the truncation errors and global errors of the numerical solutions for the schemes to end the theoretical analysis. Extensive numerical tests show the accordance between the theoretical and numerical results

  3. Canonical symplectic particle-in-cell method for long-term large-scale simulations of the Vlasov–Maxwell equations

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Hong; Liu, Jian; Xiao, Jianyuan; Zhang, Ruili; He, Yang; Wang, Yulei; Sun, Yajuan; Burby, Joshua W.; Ellison, Leland; Zhou, Yao

    2015-12-14

    Particle-in-cell (PIC) simulation is the most important numerical tool in plasma physics. However, its long-term accuracy has not been established. To overcome this difficulty, we developed a canonical symplectic PIC method for the Vlasov-Maxwell system by discretising its canonical Poisson bracket. A fast local algorithm to solve the symplectic implicit time advance is discovered without root searching or global matrix inversion, enabling applications of the proposed method to very large-scale plasma simulations with many, e.g. 10(9), degrees of freedom. The long-term accuracy and fidelity of the algorithm enables us to numerically confirm Mouhot and Villani's theory and conjecture on nonlinear Landau damping over several orders of magnitude using the PIC method, and to calculate the nonlinear evolution of the reflectivity during the mode conversion process from extraordinary waves to Bernstein waves.

  4. Prospective, Randomized, Double-Blind, Parallel-Group, Comparative Effectiveness Clinical Trial Comparing a Powder Vehicle Compound of Vitamin D With an Oil Vehicle Compound in Adults With Cystic Fibrosis.

    Science.gov (United States)

    Hermes, Wendy A; Alvarez, Jessica A; Lee, Moon J; Chesdachai, Supavit; Lodin, Daud; Horst, Ron; Tangpricha, Vin

    2017-08-01

    There is little consensus on the most efficacious vehicle substance for vitamin D supplements. Fat malabsorption may impede the ability of patients with cystic fibrosis (CF) to absorb vitamin D in an oil vehicle. We hypothesized that vitamin D contained in a powder vehicle would be absorbed more efficiently than vitamin D contained in an oil vehicle in patients with CF. In this double-blind, randomized controlled trial, hospitalized adults with CF were given a one-time bolus dose of 100,000 IU of cholecalciferol (D 3 ) in a powder-based or oil-based vehicle. Serum D 3 , 25-hydroxyvitamin D, and parathyroid hormone concentrations were analyzed at 0, 12, 24, and 48 hours posttreatment. The area under the curve for serum D 3 and the 12-hour time point were also assessed as indicators of D 3 absorption. This trial was completed by 15 patients with CF. The median (interquartile range) age, body mass index, and forced expiratory volume in 1 second were 23.7 (19.9-33.2) years, 19.9 (18.6-22.6) kg/m 2 , and 63% (37%-80%), respectively. The increase in serum D 3 and the area under the curve was greater in the powder group ( P = .002 and P = .036, respectively). Serum D 3 was higher at 12 hours in the powder group compared with the oil group ( P = .002), although levels were similar between groups by 48 hours. In adults with CF, cholecalciferol is more efficiently absorbed in a powder compared with an oil vehicle. Physicians should consider prescribing vitamin D in a powder vehicle in patients with CF to improve the absorption of vitamin D from supplements.

  5. Exploratory double-blind, parallel-group, placebo-controlled study of edaravone (MCI-186) in amyotrophic lateral sclerosis (Japan ALS severity classification: Grade 3, requiring assistance for eating, excretion or ambulation).

    Science.gov (United States)

    2017-10-01

    Our objective was to explore the efficacy and safety of edaravone in amyotrophic lateral sclerosis (ALS) patients with a Japan ALS severity classification of Grade 3. In a 24-week, double-blind, randomized study, 25 patients who met all of the following criteria were enrolled: Japan ALS severity classification Grade 3; definite, probable, or probable-laboratory supported ALS (El Escorial/revised Airlie House); forced vital capacity (%FVC) ≥60%; duration of disease ≤3 years at consent; and change in the revised ALS functional rating scale (ALSFRS-R) score of -1 to -4 points during the 12-week pre-observation period. Patients received edaravone (n = 13) or placebo (n = 12) for six cycles. The efficacy outcome was change in the ALSFRS-R score. The least-squares mean change in the ALSFRS-R score ± standard error during the 24-week treatment was -6.52 ± 1.78 in the edaravone group and -6.00 ± 1.83 in the placebo group; the difference of -0.52 ± 2.46 was not statistically significant (p = 0.835). Incidence of adverse events was 92.3% (12/13) in the edaravone group and 100.0% (12/12) in the placebo group. There was no intergroup difference in the changes in the ALSFRS-R score. The incidences of adverse events were similar in the two groups.

  6. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.

    Science.gov (United States)

    Murata, Yoko; Song, Michael; Kikuchi, Hisayuki; Hisamichi, Katsuya; Xu, Xie L; Greenspan, Andrew; Kato, Mai; Chiou, Chiun-Fang; Kato, Takeshi; Guzzo, Cynthia; Thurmond, Robin L; Ohtsuki, Mamitaro; Furue, Masutaka

    2015-02-01

    This trial was conducted to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult Japanese patients with moderate atopic dermatitis (AD). Eligible patients were randomly assigned to JNJ-39758979 300 mg, 100 mg or placebo once daily for 6 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study. Primary efficacy was assessed via week-6 Eczema Area and Severity Index (EASI) scores. Secondary efficacy assessments included Investigator's Global Assessment (IGA) and patient-reported outcome (PRO) pruritus assessments (Pruritus Categorical Response Scale [PCRS], Pruritus Numeric Rating Scales [PNRS], Pruritus Interference Numeric Rating Scale [PINRS] and Subject's Global Impressions of Change in Pruritus [SGICP]). Eighty-eight of 105 planned patients were randomized before the study was stopped and unblinded for safety reasons. The study did not meet the primary end-point. However, numerical improvements (i.e. decreases) in median EASI were observed with JNJ-39758979 100 mg (-3.7) and 300 mg (-3.0) versus placebo (-1.3) at week 6. Nominally significant improvements across PRO PCRS, PNRS and SGICP assessments were consistently observed, particularly with JNJ-39758979 300 mg. Safety, including adverse events (AE), was comparable between JNJ-39758979 and placebo with the exception of two patients (both receiving JNJ-39758979 300 mg) with serious AE of neutropenia, leading to premature study discontinuation. No deaths were reported. Except for neutropenia, no clinically relevant changes in laboratory values were observed. Although not conclusive, findings suggest H4 R-antagonism may be beneficial for AD, particularly in controlling pruritus. JNJ-39758979 appears to be associated with drug-induced agranulocytosis, likely an off-target effect. © 2014 Japanese Dermatological Association.

  7. Efficacy and safety of 1 % terbinafine film-forming solution in Chinese patients with tinea pedis: a randomized, double-blind, placebo-controlled, multicenter, parallel-group study.

    Science.gov (United States)

    Li, Ruo Yu; Wang, A P; Xu, J H; Xi, L Y; Fu, M H; Zhu, M; Xu, M L; Li, X Q; Lai, W; Liu, W D; Lu, X Y; Gong, Z Q

    2014-03-01

    Superficial fungal skin infections are treated using topical antifungals. The aim of this study was to demonstrate the efficacy of a single application of 1 % terbinafine film-forming solution (FFS) versus placebo for the treatment of tinea pedis in the Chinese population. Six centers in China randomized 290 patients in a 1:1 ratio to receive either 1 % terbinafine FFS or FFS vehicle (placebo) once on the affected foot/feet. Efficacy assessments included microscopy and mycologic culture, and assessing clinical signs and symptoms at baseline, and at weeks 1 and 6 after the topical treatment. All adverse events were recorded. At week 6, 1 % terbinafine FFS was superior to placebo for effective treatment rate (63 vs. 8 %); clinical cure (30 vs. 6 %); mycological cure (86 vs. 12 %); negative microscopy (90 vs. 24 %); and negative mycological culture (90 vs. 27 %): all p ≤ 0.001 and clinically relevant. At week 6, 1 % terbinafine FFS was clinically superior to placebo for the absence of: erythema (69 vs. 29 %); desquamation (33 vs. 8 %); and pruritus (70 vs. 30 %): all p ≤ 0.001 and clinically relevant. At week 6, differences in the average total signs and symptoms scores were significantly lower for 1 % terbinafine FFS versus placebo (p ≤ 0.001). Both 1 % terbinafine FFS and placebo were safe and well tolerated based on adverse events and investigator and patient assessments. This double-blind, randomized, multicenter study demonstrated one single topical application of 1 % terbinafine FFS was safe and effective in the treatment of tinea pedis in the Chinese population.

  8. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms

    Directory of Open Access Journals (Sweden)

    Feldman Samantha

    2009-11-01

    Full Text Available Abstract Background This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence but no gastrointestinal (GI diagnoses to explain the symptoms. Methods Sixty-one adults were enrolled (age 36.5 ± 12.6 years; height 165.1 ± 9.2 cm; weight 75.4 ± 17.3 kg and randomized to either Digestive Advantage™ Gas Defense Formula - (GanedenBC30 Bacillus coagulans GBI-30, 6086: n = 30; or Placebo: n = 31. Study subjects were evaluated every two weeks over a four-week period using validated questionnaires and standard biochemical safety testing. Outcome criteria of interest included change from baseline in Gastrointestinal Symptom Rating Scale (GSRS abdominal pain, abdominal distention, flatus, and the Severity of Dyspepsia Assessment (SODA bloating and gas subscores over four weeks of product use. Results Measured against the placebo, subjects in the probiotic group achieved significant improvements in GSRS abdominal pain subscore (p = 0.046 and the GSRS total score (p = 0.048, with a strong trend for improvement on the GSRS abdominal distension subscore (p = 0.061. A strong placebo effect was evident which could explain the lack of statistical significant differences between the groups for many of the efficacy variables. Conclusion In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses. Trial Registration ClinicalTrials.gov Identifier: NCT00881322

  9. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms

    Science.gov (United States)

    2009-01-01

    Background This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence) but no gastrointestinal (GI) diagnoses to explain the symptoms. Methods Sixty-one adults were enrolled (age 36.5 ± 12.6 years; height 165.1 ± 9.2 cm; weight 75.4 ± 17.3 kg) and randomized to either Digestive Advantage™ Gas Defense Formula - (GanedenBC30 Bacillus coagulans GBI-30, 6086): n = 30; or Placebo: n = 31. Study subjects were evaluated every two weeks over a four-week period using validated questionnaires and standard biochemical safety testing. Outcome criteria of interest included change from baseline in Gastrointestinal Symptom Rating Scale (GSRS) abdominal pain, abdominal distention, flatus, and the Severity of Dyspepsia Assessment (SODA) bloating and gas subscores over four weeks of product use. Results Measured against the placebo, subjects in the probiotic group achieved significant improvements in GSRS abdominal pain subscore (p = 0.046) and the GSRS total score (p = 0.048), with a strong trend for improvement on the GSRS abdominal distension subscore (p = 0.061). A strong placebo effect was evident which could explain the lack of statistical significant differences between the groups for many of the efficacy variables. Conclusion In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses. Trial Registration ClinicalTrials.gov Identifier: NCT00881322 PMID:19922649

  10. Effects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: a randomized, double-blind, parallel trial

    Directory of Open Access Journals (Sweden)

    T. Öztürk

    2015-04-01

    Full Text Available Myocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval (QTc prolongation. The objective of this randomized, double-blind trial was to determine the effects of high- vs conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias following anesthesia induction and intubation. Fifty patients about to undergo coronary artery surgery were randomly allocated to receive conventional-dose (0.6 mg/kg, group C, n=25 or high-dose (1.2 mg/kg, group H, n=25 rocuronium after induction with etomidate and fentanyl. QTc, heart rate, and mean arterial pressure were recorded before induction (T0, after induction (T1, after rocuronium (just before laryngoscopy; T2, 2 min after intubation (T3, and 5 min after intubation (T4. The occurrence of dysrhythmias was recorded. In both groups, QTc was significantly longer at T3 than at baseline [475 vs 429 ms in group C (P=0.001, and 459 vs 434 ms in group H (P=0.005]. The incidence of dysrhythmias in group C (28% and in group H (24% was similar. The QTc after high-dose rocuronium was not significantly longer than after conventional-dose rocuronium in patients about to undergo coronary artery surgery who were induced with etomidate and fentanyl. In both groups, compared with baseline, QTc was most prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to the nociceptive stimulus of intubation.

  11. Study protocol: a phase III randomised, double-blind, parallel arm, stratified, block randomised, placebo-controlled trial investigating the clinical effect and cost-effectiveness of sertraline for the palliative relief of breathlessness in people with chronic breathlessness.

    Science.gov (United States)

    Watts, Gareth J; Clark, Katherine; Agar, Meera; Davidson, Patricia M; McDonald, Christine; Lam, Lawrence T; Sajkov, Dimitar; McCaffrey, Nicola; Doogue, Matthew; Abernethy, Amy P; Currow, David C

    2016-11-29

    Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness. This paper presents the protocol for a large, adequately powered randomised study evaluating the use of sertraline for chronic breathlessness in people with progressive life-limiting illnesses. A total of 240 participants with modified Medical Research Council Dyspnoea Scale breathlessness of level 2 or higher will be randomised to receive either sertraline or placebo for 28 days in this multisite, double-blind study. The dose will be titrated up every 3 days to a maximum of 100 mg daily. The primary outcome will be to compare the efficacy of sertraline with placebo in relieving the intensity of worst breathlessness as assessed by a 0-100 mm Visual Analogue Scale. A number of other outcome measures and descriptors of breathlessness as well as caregiver assessments will also be recorded to ensure adequate analysis of participant breathlessness and to allow an economic analysis to be performed. Participants will also be given the option of continuing blinded treatment until either study data collection is complete or net benefit ceases. Appropriate statistical analysis of primary and secondary outcomes will be used to describe the wealth of data obtained. Ethics approval was obtained at all participating sites. Results of the study will be submitted for publication in peer-reviewed journals and the key findings presented at national and international conferences. ACTRN12610000464066. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a

  12. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms.

    Science.gov (United States)

    Kalman, Douglas S; Schwartz, Howard I; Alvarez, Patricia; Feldman, Samantha; Pezzullo, John C; Krieger, Diane R

    2009-11-18

    This randomized double blind placebo controlled dual site clinical trial compared a probiotic dietary supplement to placebo regarding effects on gastrointestinal symptoms in adults with post-prandial intestinal gas-related symptoms (abdominal pain, distention, flatulence) but no gastrointestinal (GI) diagnoses to explain the symptoms. Sixty-one adults were enrolled (age 36.5 +/- 12.6 years; height 165.1 +/- 9.2 cm; weight 75.4 +/- 17.3 kg) and randomized to either Digestive Advantage Gas Defense Formula - (GanedenBC30 Bacillus coagulans GBI-30, 6086): n = 30; or Placebo: n = 31. Study subjects were evaluated every two weeks over a four-week period using validated questionnaires and standard biochemical safety testing. Outcome criteria of interest included change from baseline in Gastrointestinal Symptom Rating Scale (GSRS) abdominal pain, abdominal distention, flatus, and the Severity of Dyspepsia Assessment (SODA) bloating and gas subscores over four weeks of product use. Measured against the placebo, subjects in the probiotic group achieved significant improvements in GSRS abdominal pain subscore (p = 0.046) and the GSRS total score (p = 0.048), with a strong trend for improvement on the GSRS abdominal distension subscore (p = 0.061). A strong placebo effect was evident which could explain the lack of statistical significant differences between the groups for many of the efficacy variables. In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses. ClinicalTrials.gov Identifier: NCT00881322.

  13. A parallel buffer tree

    DEFF Research Database (Denmark)

    Sitchinava, Nodar; Zeh, Norbert

    2012-01-01

    We present the parallel buffer tree, a parallel external memory (PEM) data structure for batched search problems. This data structure is a non-trivial extension of Arge's sequential buffer tree to a private-cache multiprocessor environment and reduces the number of I/O operations by the number of...... in the optimal OhOf(psortN + K/PB) parallel I/O complexity, where K is the size of the output reported in the process and psortN is the parallel I/O complexity of sorting N elements using P processors....

  14. Parallel MR imaging.

    Science.gov (United States)

    Deshmane, Anagha; Gulani, Vikas; Griswold, Mark A; Seiberlich, Nicole

    2012-07-01

    Parallel imaging is a robust method for accelerating the acquisition of magnetic resonance imaging (MRI) data, and has made possible many new applications of MR imaging. Parallel imaging works by acquiring a reduced amount of k-space data with an array of receiver coils. These undersampled data can be acquired more quickly, but the undersampling leads to aliased images. One of several parallel imaging algorithms can then be used to reconstruct artifact-free images from either the aliased images (SENSE-type reconstruction) or from the undersampled data (GRAPPA-type reconstruction). The advantages of parallel imaging in a clinical setting include faster image acquisition, which can be used, for instance, to shorten breath-hold times resulting in fewer motion-corrupted examinations. In this article the basic concepts behind parallel imaging are introduced. The relationship between undersampling and aliasing is discussed and two commonly used parallel imaging methods, SENSE and GRAPPA, are explained in detail. Examples of artifacts arising from parallel imaging are shown and ways to detect and mitigate these artifacts are described. Finally, several current applications of parallel imaging are presented and recent advancements and promising research in parallel imaging are briefly reviewed. Copyright © 2012 Wiley Periodicals, Inc.

  15. Parallel Algorithms and Patterns

    Energy Technology Data Exchange (ETDEWEB)

    Robey, Robert W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-16

    This is a powerpoint presentation on parallel algorithms and patterns. A parallel algorithm is a well-defined, step-by-step computational procedure that emphasizes concurrency to solve a problem. Examples of problems include: Sorting, searching, optimization, matrix operations. A parallel pattern is a computational step in a sequence of independent, potentially concurrent operations that occurs in diverse scenarios with some frequency. Examples are: Reductions, prefix scans, ghost cell updates. We only touch on parallel patterns in this presentation. It really deserves its own detailed discussion which Gabe Rockefeller would like to develop.

  16. Application Portable Parallel Library

    Science.gov (United States)

    Cole, Gary L.; Blech, Richard A.; Quealy, Angela; Townsend, Scott

    1995-01-01

    Application Portable Parallel Library (APPL) computer program is subroutine-based message-passing software library intended to provide consistent interface to variety of multiprocessor computers on market today. Minimizes effort needed to move application program from one computer to another. User develops application program once and then easily moves application program from parallel computer on which created to another parallel computer. ("Parallel computer" also include heterogeneous collection of networked computers). Written in C language with one FORTRAN 77 subroutine for UNIX-based computers and callable from application programs written in C language or FORTRAN 77.

  17. Self-Reported quality of life in adults with attention-deficit/hyperactivity disorder and executive function impairment treated with lisdexamfetamine dimesylate: a randomized, double-blind, multicenter, placebo-controlled, parallel-group study.

    Science.gov (United States)

    Adler, Lenard A; Dirks, Bryan; Deas, Patrick; Raychaudhuri, Aparna; Dauphin, Matthew; Saylor, Keith; Weisler, Richard

    2013-10-09

    This study examined the effects of lisdexamfetamine dimesylate (LDX) on quality of life (QOL) in adults with attention-deficit/hyperactivity disorder (ADHD) and clinically significant executive function deficits (EFD). This report highlights QOL findings from a 10-week randomized placebo-controlled trial of LDX (30-70 mg/d) in adults (18-55 years) with ADHD and EFD (Behavior Rating Inventory of EF-Adult, Global Executive Composite [BRIEF-A GEC] ≥65). The primary efficacy measure was the self-reported BRIEF-A; a key secondary measure was self-reported QOL on the Adult ADHD Impact Module (AIM-A). The clinician-completed ADHD Rating Scale version IV (ADHD-RS-IV) with adult prompts and Clinical Global Impressions-Severity (CGI-S) were also employed. The Adult ADHD QoL (AAQoL) was added while the study was in progress. A post hoc analysis examined the subgroup having evaluable results from both AIM-A and AAQoL. Of 161 randomized (placebo, 81; LDX, 80), 159 were included in the safety population. LDX improved AIM-A multi-item domain scores versus placebo; LS mean difference for Performance and Daily Functioning was 21.6 (ES, 0.93, PPsychological Health was 12.1; Life Outlook was 12.5; and Relationships was 7.3. In a post hoc analysis of participants with both AIM-A and AAQoL scores, AIM-A multi-item subgroup analysis scores numerically improved with LDX, with smaller difference for Impact of Symptoms: Daily Interference. The safety profile of LDX was consistent with amphetamine use in previous studies. Overall, adults with ADHD/EFD exhibited self-reported improvement on QOL, using the AIM-A and AAQoL scales in line with medium/large ES; these improvements were paralleled by improvements in EF and ADHD symptoms. The safety profile of LDX was similar to previous studies. ClinicalTrials.gov, NCT01101022.

  18. A hybrid symplectic principal component analysis and central tendency measure method for detection of determinism in noisy time series with application to mechanomyography.

    Science.gov (United States)

    Xie, Hong-Bo; Dokos, Socrates

    2013-06-01

    We present a hybrid symplectic geometry and central tendency measure (CTM) method for detection of determinism in noisy time series. CTM is effective for detecting determinism in short time series and has been applied in many areas of nonlinear analysis. However, its performance significantly degrades in the presence of strong noise. In order to circumvent this difficulty, we propose to use symplectic principal component analysis (SPCA), a new chaotic signal de-noising method, as the first step to recover the system dynamics. CTM is then applied to determine whether the time series arises from a stochastic process or has a deterministic component. Results from numerical experiments, ranging from six benchmark deterministic models to 1/f noise, suggest that the hybrid method can significantly improve detection of determinism in noisy time series by about 20 dB when the data are contaminated by Gaussian noise. Furthermore, we apply our algorithm to study the mechanomyographic (MMG) signals arising from contraction of human skeletal muscle. Results obtained from the hybrid symplectic principal component analysis and central tendency measure demonstrate that the skeletal muscle motor unit dynamics can indeed be deterministic, in agreement with previous studies. However, the conventional CTM method was not able to definitely detect the underlying deterministic dynamics. This result on MMG signal analysis is helpful in understanding neuromuscular control mechanisms and developing MMG-based engineering control applications.

  19. A Randomized Double-Blind, Placebo Controlled, Four-Arm Parallel Study Investigating the Effect of a Broad-Spectrum Wellness Beverage on Mood State in Healthy, Moderately Stressed Adults.

    Science.gov (United States)

    Evans, Malkanthi; Antony, Joseph; Guthrie, Najla; Landes, Bernie; Aruoma, Okezie I

    2018-01-01

    The objective of this study was to investigate the effect of a broad-spectrum wellness beverage (Zeal Wellness [ZW]) on standardized measures of mood states, including overall feelings of vitality, in healthy, moderately stressed adults. A randomized, double-blind, placebo-controlled clinical trial was conducted among 99 eligible participants prescreened for moderate stress. Participants were randomized to one of four groups and received ZW once daily (1-dose-ZW; 14 g), ZW twice daily (2-dose-ZW; 28 g), placebo once daily (1-dose-placebo), or placebo twice daily (2-dose-placebo) for 4 weeks. A stress/vitality questionnaire assessed stress and the Profile of Moods (POMS) Questionnaire assessed vigor via mental/physical energy and global mood state. Safety was assessed by clinical chemistry, liver, kidney function, and anthropometric measures and adverse event reporting. Participants receiving 2-dose-ZW reported a 6.6% decrease in scores on POMS-Total Mood Disturbance (TMD; p < 0.05) and a 6.8% decrease in the anger-hostility mood state (p < 0.022) compared to the combined placebo group at day 29. The 2-dose-ZW provided a 12.8% greater improvement in POMS-TMD scores when compared to participants receiving 1-dose-ZW after 28 days of supplementation (p = 0.014). Within groups, there was a 22.4% and a 9.6% decrease in POMS-TMD scores in participants with 2-dose-ZW and 1-dose-ZW, respectively. In addition, participants receiving 2-dose-ZW showed significant improvements (p = 0.001) in the POMS t-score iceberg profile, which represented a shift to a more healthy profile. These data show that daily supplementation with 2-dose-ZW significantly decreased POMS-TMD scores and anger-hostility mood state and shifted the POMS iceberg profile to a healthy profile compared to the combined placebo, reflecting the functional benefit of rice-bran-fruit-vegetable extracts based beverage on health.

  20. Double layers above the aurora

    International Nuclear Information System (INIS)

    Temerin, M.; Mozer, F.S.

    1987-01-01

    Two different kinds of double layers were found in association with auroral precipitation. One of these is the so-called electrostatic shock, which is oriented at an oblique angle to the magnetic field in such a way that the perpendicular electric field is much larger than the parallel electric field. This type of double layer is often found at the edges of regions of upflowing ion beams and the direction of the electric fields in the shock points toward the ion beam. The potential drop through the shock can be several kV and is comparable to the total potential needed to produce auroral acceleration. Instabilities associated with the shock may generate obliquely propagating Alfven waves, which may accelerate electrons to produce flickering auroras. The flickering aurora provides evidence that the electrostatic shock may have large temporal fluctuations. The other kind of double layer is the small-amplitude double layer found in regions of upward flowing in beams, often in association with electrostatic ion cyclotron waves. The parallel and perpendicular electric fields in these structures are comparable in magnitude. The associated potentials are a few eV. Since many such double layers are found in regions of upward flowing ion beams, the combined potential drop through a set of these double layers can be substantial

  1. A 6-week, multicenter, randomized, double-masked, parallel-group study comparing travoprost 0.004% to latanoprost 0.005% followed by 6-week, open-label treatment with travoprost 0.004%.

    Science.gov (United States)

    Maul, Eugenio; Carrasco, Félix Gil; Costa, Vital Paulino; Casiraghi, Javier F; Vargas, Enrique; Sarmina, Judith S; Mayol, Renato

    2007-09-01

    The aim of this study was to compare the tolerability and efficacy of once-daily travoprost 0.004% versus latanoprost 0.005% for 6 weeks followed by 6 weeks of once-daily travoprost 0.004% in decreasing intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OH). This multicenter, randomized, doublemasked, active-controlled, parallel-group trial was conducted at 32 centers across Latin America. Patients aged > or =18 years with OAG or OH were randomly assigned to receive topical travoprost 0.004% or latanoprost 0.005% 1 drop QD (9 PM) for 6 weeks (masked phase). At 6 weeks, all patients were assigned to receive open-label travoprost 0.004% 1 drop QD (9 PM) for 6 additional weeks (open-label phase). Study visits were scheduled at weeks 1, 2, 4, 6, 8, and 12. At each study visit, IOP was measured at 5 PM (+/-1 hour; approximately 20 hours after study drug administration). IOP changes from baseline were combined (pooled) from the 1-, 2-, 4-, and 6-week data to provide a comparison between the 2 treatment groups. Ocular adverse events (AEs) were monitored using slit-lamp examination. A total of 302 patients were enrolled (travoprost group, 155 patients; latanoprost group, 147 patients). The mean (SD) age of the travoprost group was 61.9 (10.6) years; 60.6% were female; and 47.1% were white. The mean (SD) age of the latanoprost group was 60.5 (12.4) years; 62.6% were female; and 49.0% were white. Mean IOP values were not significantly different between the travoprost and latanoprost groups at baseline (24.7 vs 24.2 mm Hg) or 6 weeks; however, the between-group difference in reductions from baseline in pooled IOP during the masked phase of the study was statistically significant (-8.3 vs -7.5 mm Hg; P = 0.009). At weeks 6 and 12, mean lOP levels were 16.1 and 16.2 mm Hg, respectively, in the travoprost group and 16.4 and 16.1 mm Hg in the group that was switched from latanoprost to travoprost (all, P = NS). The most common ocular AEs

  2. Parallel discrete event simulation

    NARCIS (Netherlands)

    Overeinder, B.J.; Hertzberger, L.O.; Sloot, P.M.A.; Withagen, W.J.

    1991-01-01

    In simulating applications for execution on specific computing systems, the simulation performance figures must be known in a short period of time. One basic approach to the problem of reducing the required simulation time is the exploitation of parallelism. However, in parallelizing the simulation

  3. Parallel reservoir simulator computations

    International Nuclear Information System (INIS)

    Hemanth-Kumar, K.; Young, L.C.

    1995-01-01

    The adaptation of a reservoir simulator for parallel computations is described. The simulator was originally designed for vector processors. It performs approximately 99% of its calculations in vector/parallel mode and relative to scalar calculations it achieves speedups of 65 and 81 for black oil and EOS simulations, respectively on the CRAY C-90

  4. Totally parallel multilevel algorithms

    Science.gov (United States)

    Frederickson, Paul O.

    1988-01-01

    Four totally parallel algorithms for the solution of a sparse linear system have common characteristics which become quite apparent when they are implemented on a highly parallel hypercube such as the CM2. These four algorithms are Parallel Superconvergent Multigrid (PSMG) of Frederickson and McBryan, Robust Multigrid (RMG) of Hackbusch, the FFT based Spectral Algorithm, and Parallel Cyclic Reduction. In fact, all four can be formulated as particular cases of the same totally parallel multilevel algorithm, which are referred to as TPMA. In certain cases the spectral radius of TPMA is zero, and it is recognized to be a direct algorithm. In many other cases the spectral radius, although not zero, is small enough that a single iteration per timestep keeps the local error within the required tolerance.

  5. Parallel computing works

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-23

    An account of the Caltech Concurrent Computation Program (C{sup 3}P), a five year project that focused on answering the question: Can parallel computers be used to do large-scale scientific computations '' As the title indicates, the question is answered in the affirmative, by implementing numerous scientific applications on real parallel computers and doing computations that produced new scientific results. In the process of doing so, C{sup 3}P helped design and build several new computers, designed and implemented basic system software, developed algorithms for frequently used mathematical computations on massively parallel machines, devised performance models and measured the performance of many computers, and created a high performance computing facility based exclusively on parallel computers. While the initial focus of C{sup 3}P was the hypercube architecture developed by C. Seitz, many of the methods developed and lessons learned have been applied successfully on other massively parallel architectures.

  6. Massively parallel mathematical sieves

    Energy Technology Data Exchange (ETDEWEB)

    Montry, G.R.

    1989-01-01

    The Sieve of Eratosthenes is a well-known algorithm for finding all prime numbers in a given subset of integers. A parallel version of the Sieve is described that produces computational speedups over 800 on a hypercube with 1,024 processing elements for problems of fixed size. Computational speedups as high as 980 are achieved when the problem size per processor is fixed. The method of parallelization generalizes to other sieves and will be efficient on any ensemble architecture. We investigate two highly parallel sieves using scattered decomposition and compare their performance on a hypercube multiprocessor. A comparison of different parallelization techniques for the sieve illustrates the trade-offs necessary in the design and implementation of massively parallel algorithms for large ensemble computers.

  7. Early (≤ 1-h) vs. late (>1-h) administration of frovatriptan plus dexketoprofen combination vs. frovatriptan monotherapy in the acute treatment of migraine attacks with or without aura: a post hoc analysis of a double-blind, randomized, parallel group study.

    Science.gov (United States)

    Allais, Gianni; Bussone, Gennaro; Tullo, Vincenzo; Cortelli, Pietro; Valguarnera, Fabio; Barbanti, Piero; Sette, Giuliano; Frediani, Fabio; D'Arrigo, Giacomo; d'Onofrio, Florindo; Comi, Giancarlo; Curone, Marcella; Colombo, Bruno; Omboni, Stefano; Benedetto, Chiara

    2015-05-01

    The early use of triptan in combination with a nonsteroidal anti-inflammatory drug after headache onset may improve the efficacy of acute migraine treatment. In this retrospective analysis of a randomized, double-blind, parallel group study, we assessed the efficacy of early or late intake of frovatriptan 2.5 mg + dexketoprofen 25 or 37.5 mg (FroDex 25 and FroDex 37.5) vs. frovatriptan 2.5 mg alone (Frova) in the acute treatment of migraine attacks. In this double-blind, randomized parallel group study 314 subjects with acute migraine with or without aura were randomly assigned to Frova, FroDex 25, or FroDex 37.5. Pain free (PF) at 2-h (primary endpoint), PF at 4-h and pain relief (PR) at 2 and 4-h, speed of onset at 60, 90, 120 and 240-min, and sustained pain free (SPF) at 24-h were compared across study groups according to early (≤1-h; n = 220) or late (>1-h; n = 59) intake. PF rates at 2 and 4-h were significantly larger with FroDex 37.5 vs. Frova (early intake, n = 71 FroDex 37.5 and n = 75 Frova: 49 vs. 32 % and 68 vs. 52 %, p < 0.05; late intake, n = 20 Frodex 37.5, and n = 18 Frova: 55 vs. 17 %, p < 0.05 and 85 vs. 28 %, p < 0.01). Also with FroDex 25, in the early intake group (n = 74) PF episodes were significantly higher than Frova. PR at 2 and 4-h was significantly better under FroDex 37.5 than Frova (95 % vs. 50 %, p < 0.001, 100 % vs. 72 %, p < 0.05) in the late intake group (n = 21). SPF episodes at 24-h after early dosing were 25 % (Frova), 45 % (FroDex 25) and 41 % (FroDex 37.5, p < 0.05 combinations vs. monotherapy), whereas they were not significantly different with late intake. All treatments were equally well tolerated. FroDex was similarly effective regardless of intake timing from headache onset.

  8. Algorithms for parallel computers

    International Nuclear Information System (INIS)

    Churchhouse, R.F.

    1985-01-01

    Until relatively recently almost all the algorithms for use on computers had been designed on the (usually unstated) assumption that they were to be run on single processor, serial machines. With the introduction of vector processors, array processors and interconnected systems of mainframes, minis and micros, however, various forms of parallelism have become available. The advantage of parallelism is that it offers increased overall processing speed but it also raises some fundamental questions, including: (i) which, if any, of the existing 'serial' algorithms can be adapted for use in the parallel mode. (ii) How close to optimal can such adapted algorithms be and, where relevant, what are the convergence criteria. (iii) How can we design new algorithms specifically for parallel systems. (iv) For multi-processor systems how can we handle the software aspects of the interprocessor communications. Aspects of these questions illustrated by examples are considered in these lectures. (orig.)

  9. Parallelism and array processing

    International Nuclear Information System (INIS)

    Zacharov, V.

    1983-01-01

    Modern computing, as well as the historical development of computing, has been dominated by sequential monoprocessing. Yet there is the alternative of parallelism, where several processes may be in concurrent execution. This alternative is discussed in a series of lectures, in which the main developments involving parallelism are considered, both from the standpoint of computing systems and that of applications that can exploit such systems. The lectures seek to discuss parallelism in a historical context, and to identify all the main aspects of concurrency in computation right up to the present time. Included will be consideration of the important question as to what use parallelism might be in the field of data processing. (orig.)

  10. Parallel magnetic resonance imaging

    International Nuclear Information System (INIS)

    Larkman, David J; Nunes, Rita G

    2007-01-01

    Parallel imaging has been the single biggest innovation in magnetic resonance imaging in the last decade. The use of multiple receiver coils to augment the time consuming Fourier encoding has reduced acquisition times significantly. This increase in speed comes at a time when other approaches to acquisition time reduction were reaching engineering and human limits. A brief summary of spatial encoding in MRI is followed by an introduction to the problem parallel imaging is designed to solve. There are a large number of parallel reconstruction algorithms; this article reviews a cross-section, SENSE, SMASH, g-SMASH and GRAPPA, selected to demonstrate the different approaches. Theoretical (the g-factor) and practical (coil design) limits to acquisition speed are reviewed. The practical implementation of parallel imaging is also discussed, in particular coil calibration. How to recognize potential failure modes and their associated artefacts are shown. Well-established applications including angiography, cardiac imaging and applications using echo planar imaging are reviewed and we discuss what makes a good application for parallel imaging. Finally, active research areas where parallel imaging is being used to improve data quality by repairing artefacted images are also reviewed. (invited topical review)

  11. The STAPL Parallel Graph Library

    KAUST Repository

    Harshvardhan,; Fidel, Adam; Amato, Nancy M.; Rauchwerger, Lawrence

    2013-01-01

    This paper describes the stapl Parallel Graph Library, a high-level framework that abstracts the user from data-distribution and parallelism details and allows them to concentrate on parallel graph algorithm development. It includes a customizable

  12. Massively parallel multicanonical simulations

    Science.gov (United States)

    Gross, Jonathan; Zierenberg, Johannes; Weigel, Martin; Janke, Wolfhard

    2018-03-01

    Generalized-ensemble Monte Carlo simulations such as the multicanonical method and similar techniques are among the most efficient approaches for simulations of systems undergoing discontinuous phase transitions or with rugged free-energy landscapes. As Markov chain methods, they are inherently serial computationally. It was demonstrated recently, however, that a combination of independent simulations that communicate weight updates at variable intervals allows for the efficient utilization of parallel computational resources for multicanonical simulations. Implementing this approach for the many-thread architecture provided by current generations of graphics processing units (GPUs), we show how it can be efficiently employed with of the order of 104 parallel walkers and beyond, thus constituting a versatile tool for Monte Carlo simulations in the era of massively parallel computing. We provide the fully documented source code for the approach applied to the paradigmatic example of the two-dimensional Ising model as starting point and reference for practitioners in the field.

  13. SPINning parallel systems software

    International Nuclear Information System (INIS)

    Matlin, O.S.; Lusk, E.; McCune, W.

    2002-01-01

    We describe our experiences in using Spin to verify parts of the Multi Purpose Daemon (MPD) parallel process management system. MPD is a distributed collection of processes connected by Unix network sockets. MPD is dynamic processes and connections among them are created and destroyed as MPD is initialized, runs user processes, recovers from faults, and terminates. This dynamic nature is easily expressible in the Spin/Promela framework but poses performance and scalability challenges. We present here the results of expressing some of the parallel algorithms of MPD and executing both simulation and verification runs with Spin

  14. Parallel programming with Python

    CERN Document Server

    Palach, Jan

    2014-01-01

    A fast, easy-to-follow and clear tutorial to help you develop Parallel computing systems using Python. Along with explaining the fundamentals, the book will also introduce you to slightly advanced concepts and will help you in implementing these techniques in the real world. If you are an experienced Python programmer and are willing to utilize the available computing resources by parallelizing applications in a simple way, then this book is for you. You are required to have a basic knowledge of Python development to get the most of this book.

  15. Global effects of double layers

    International Nuclear Information System (INIS)

    Raad, M.A.

    1984-12-01

    Locally the formation of an electrostatic double layer in a current carrying plasma leads to a direct acceleration of particles which may penetrate far into the surrounding medium. The potential across the double layer, giving this acceleration, must be maintained by the external system and is a basic parameter for the local to global coupling. The double layer potential is associated with an electric field parallel to the magnetic field. In general this leads to a magnetohydrodynamic relaxation of the surrounding medium providing the influx of energy which is dissipated by the double layer. The double layer potential is limited as is the maximum possible rate of energy influx. If the global response of the external medium can be represented by an external circuit and if an equivalent circuit element can be found to represent the double layer, for example a negative resistance for intermediate time scales, it is possible to give a description of the dynamics and stability of the whole system. (Author)

  16. HVI Ballistic Performance Characterization of Non-Parallel Walls

    Science.gov (United States)

    Bohl, William; Miller, Joshua; Christiansen, Eric

    2012-01-01

    The Double-Wall, "Whipple" Shield [1] has been the subject of many hypervelocity impact studies and has proven to be an effective shield system for Micro-Meteoroid and Orbital Debris (MMOD) impacts for spacecraft. The US modules of the International Space Station (ISS), with their "bumper shields" offset from their pressure holding rear walls provide good examples of effective on-orbit use of the double wall shield. The concentric cylinder shield configuration with its large radius of curvature relative to separation distance is easily and effectively represented for testing and analysis as a system of two parallel plates. The parallel plate double wall configuration has been heavily tested and characterized for shield performance for normal and oblique impacts for the ISS and other programs. The double wall shield and principally similar Stuffed Whipple Shield are very common shield types for MMOD protection. However, in some locations with many spacecraft designs, the rear wall cannot be modeled as being parallel or concentric with the outer bumper wall. As represented in Figure 1, there is an included angle between the two walls. And, with a cylindrical outer wall, the effective included angle constantly changes. This complicates assessment of critical spacecraft components located within outer spacecraft walls when using software tools such as NASA's BumperII. In addition, the validity of the risk assessment comes into question when using the standard double wall shield equations, especially since verification testing of every set of double wall included angles is impossible.

  17. Double Chooz

    Energy Technology Data Exchange (ETDEWEB)

    Buck, Christian [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany)

    2006-05-15

    The goal of the Double Chooz reactor neutrino experiment is to search for the neutrino mixing parameter {theta}{sub 13}. Double Chooz will use two identical detectors at 150 m and 1.05 km distance from the reactor cores. The near detector is used to monitor the reactor {nu}-bar {sub e} flux while the second is dedicated to the search for a deviation from the expected (1/distance){sup 2} behavior. This two detector concept will allow a relative normalization systematic error of ca. 0.6 %. The expected sensitivity for sin{sup 2}2{theta}{sub 13} is then in the range 0.02 - 0.03 after three years of data taking. The antineutrinos will be detected in a liquid scintillator through the capture on protons followed by a gamma cascade, produced by the neutron capture on Gd.

  18. Double supergeometry

    Energy Technology Data Exchange (ETDEWEB)

    Cederwall, Martin [Division for Theoretical Physics, Department of Physics, Chalmers University of Technology,SE 412 96 Gothenburg (Sweden)

    2016-06-27

    A geometry of superspace corresponding to double field theory is developed, with type I I supergravity in D=10 as the main example. The formalism is based on an orthosymplectic extension OSp(d,d|2s) of the continuous T-duality group. Covariance under generalised super-diffeomorphisms is manifest. Ordinary superspace is obtained as a solution of the orthosymplectic section condition. A systematic study of curved superspace Bianchi identities is performed, and a relation to a double pure spinor superfield cohomology is established. A Ramond-Ramond superfield is constructed as an infinite-dimensional orthosymplectic spinor. Such objects in minimal orbits under the OSp supergroup (“pure spinors”) define super-sections.

  19. Double ambidexterity

    DEFF Research Database (Denmark)

    Kaulio, Matti; Thorén, Kent; Rohrbeck, René

    2017-01-01

    We leverage the business model innovation and ambidexterity literature to investigate a contradictory case, the Swedish-Finnish Telecom operator TeliaSonera. Despite being challenged by three major disruptions, the company not only still exists but also enjoys remarkably good financial performance....... Building on extant archival data and interviews, we carefully identify and map 26 organizational responses during 1992–2016. We find that the firm has overcome three critical phases by experimenting and pioneering with portfolios of business models and/or technological innovations. We describe...... this behaviour as double ambidexterity. We use an in-depth case study to conceptualize double ambidexterity and discuss its impact on the business's survival and enduring success....

  20. Expressing Parallelism with ROOT

    Energy Technology Data Exchange (ETDEWEB)

    Piparo, D. [CERN; Tejedor, E. [CERN; Guiraud, E. [CERN; Ganis, G. [CERN; Mato, P. [CERN; Moneta, L. [CERN; Valls Pla, X. [CERN; Canal, P. [Fermilab

    2017-11-22

    The need for processing the ever-increasing amount of data generated by the LHC experiments in a more efficient way has motivated ROOT to further develop its support for parallelism. Such support is being tackled both for shared-memory and distributed-memory environments. The incarnations of the aforementioned parallelism are multi-threading, multi-processing and cluster-wide executions. In the area of multi-threading, we discuss the new implicit parallelism and related interfaces, as well as the new building blocks to safely operate with ROOT objects in a multi-threaded environment. Regarding multi-processing, we review the new MultiProc framework, comparing it with similar tools (e.g. multiprocessing module in Python). Finally, as an alternative to PROOF for cluster-wide executions, we introduce the efforts on integrating ROOT with state-of-the-art distributed data processing technologies like Spark, both in terms of programming model and runtime design (with EOS as one of the main components). For all the levels of parallelism, we discuss, based on real-life examples and measurements, how our proposals can increase the productivity of scientists.

  1. Expressing Parallelism with ROOT

    Science.gov (United States)

    Piparo, D.; Tejedor, E.; Guiraud, E.; Ganis, G.; Mato, P.; Moneta, L.; Valls Pla, X.; Canal, P.

    2017-10-01

    The need for processing the ever-increasing amount of data generated by the LHC experiments in a more efficient way has motivated ROOT to further develop its support for parallelism. Such support is being tackled both for shared-memory and distributed-memory environments. The incarnations of the aforementioned parallelism are multi-threading, multi-processing and cluster-wide executions. In the area of multi-threading, we discuss the new implicit parallelism and related interfaces, as well as the new building blocks to safely operate with ROOT objects in a multi-threaded environment. Regarding multi-processing, we review the new MultiProc framework, comparing it with similar tools (e.g. multiprocessing module in Python). Finally, as an alternative to PROOF for cluster-wide executions, we introduce the efforts on integrating ROOT with state-of-the-art distributed data processing technologies like Spark, both in terms of programming model and runtime design (with EOS as one of the main components). For all the levels of parallelism, we discuss, based on real-life examples and measurements, how our proposals can increase the productivity of scientists.

  2. Parallel Fast Legendre Transform

    NARCIS (Netherlands)

    Alves de Inda, M.; Bisseling, R.H.; Maslen, D.K.

    1998-01-01

    We discuss a parallel implementation of a fast algorithm for the discrete polynomial Legendre transform We give an introduction to the DriscollHealy algorithm using polynomial arithmetic and present experimental results on the eciency and accuracy of our implementation The algorithms were

  3. Practical parallel programming

    CERN Document Server

    Bauer, Barr E

    2014-01-01

    This is the book that will teach programmers to write faster, more efficient code for parallel processors. The reader is introduced to a vast array of procedures and paradigms on which actual coding may be based. Examples and real-life simulations using these devices are presented in C and FORTRAN.

  4. Parallel hierarchical radiosity rendering

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Michael [Iowa State Univ., Ames, IA (United States)

    1993-07-01

    In this dissertation, the step-by-step development of a scalable parallel hierarchical radiosity renderer is documented. First, a new look is taken at the traditional radiosity equation, and a new form is presented in which the matrix of linear system coefficients is transformed into a symmetric matrix, thereby simplifying the problem and enabling a new solution technique to be applied. Next, the state-of-the-art hierarchical radiosity methods are examined for their suitability to parallel implementation, and scalability. Significant enhancements are also discovered which both improve their theoretical foundations and improve the images they generate. The resultant hierarchical radiosity algorithm is then examined for sources of parallelism, and for an architectural mapping. Several architectural mappings are discussed. A few key algorithmic changes are suggested during the process of making the algorithm parallel. Next, the performance, efficiency, and scalability of the algorithm are analyzed. The dissertation closes with a discussion of several ideas which have the potential to further enhance the hierarchical radiosity method, or provide an entirely new forum for the application of hierarchical methods.

  5. Parallel universes beguile science

    CERN Multimedia

    2007-01-01

    A staple of mind-bending science fiction, the possibility of multiple universes has long intrigued hard-nosed physicists, mathematicians and cosmologists too. We may not be able -- as least not yet -- to prove they exist, many serious scientists say, but there are plenty of reasons to think that parallel dimensions are more than figments of eggheaded imagination.

  6. Parallel k-means++

    Energy Technology Data Exchange (ETDEWEB)

    2017-04-04

    A parallelization of the k-means++ seed selection algorithm on three distinct hardware platforms: GPU, multicore CPU, and multithreaded architecture. K-means++ was developed by David Arthur and Sergei Vassilvitskii in 2007 as an extension of the k-means data clustering technique. These algorithms allow people to cluster multidimensional data, by attempting to minimize the mean distance of data points within a cluster. K-means++ improved upon traditional k-means by using a more intelligent approach to selecting the initial seeds for the clustering process. While k-means++ has become a popular alternative to traditional k-means clustering, little work has been done to parallelize this technique. We have developed original C++ code for parallelizing the algorithm on three unique hardware architectures: GPU using NVidia's CUDA/Thrust framework, multicore CPU using OpenMP, and the Cray XMT multithreaded architecture. By parallelizing the process for these platforms, we are able to perform k-means++ clustering much more quickly than it could be done before.

  7. Parallel plate detectors

    International Nuclear Information System (INIS)

    Gardes, D.; Volkov, P.

    1981-01-01

    A 5x3cm 2 (timing only) and a 15x5cm 2 (timing and position) parallel plate avalanche counters (PPAC) are considered. The theory of operation and timing resolution is given. The measurement set-up and the curves of experimental results illustrate the possibilities of the two counters [fr

  8. Parallel hierarchical global illumination

    Energy Technology Data Exchange (ETDEWEB)

    Snell, Quinn O. [Iowa State Univ., Ames, IA (United States)

    1997-10-08

    Solving the global illumination problem is equivalent to determining the intensity of every wavelength of light in all directions at every point in a given scene. The complexity of the problem has led researchers to use approximation methods for solving the problem on serial computers. Rather than using an approximation method, such as backward ray tracing or radiosity, the authors have chosen to solve the Rendering Equation by direct simulation of light transport from the light sources. This paper presents an algorithm that solves the Rendering Equation to any desired accuracy, and can be run in parallel on distributed memory or shared memory computer systems with excellent scaling properties. It appears superior in both speed and physical correctness to recent published methods involving bidirectional ray tracing or hybrid treatments of diffuse and specular surfaces. Like progressive radiosity methods, it dynamically refines the geometry decomposition where required, but does so without the excessive storage requirements for ray histories. The algorithm, called Photon, produces a scene which converges to the global illumination solution. This amounts to a huge task for a 1997-vintage serial computer, but using the power of a parallel supercomputer significantly reduces the time required to generate a solution. Currently, Photon can be run on most parallel environments from a shared memory multiprocessor to a parallel supercomputer, as well as on clusters of heterogeneous workstations.

  9. Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial.

    Science.gov (United States)

    Cho, Young-Gyu; Jung, Ji-Hye; Kang, Jae-Heon; Kwon, Jin Soo; Yu, Seung Pil; Baik, Tae Gon

    2017-07-28

    YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate the efficacy and safety of YY-312 for body fat reduction in overweight adults. This was a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial performed in overweight Korean adults aged 19-60 years with a body mass index of 25.0-29.9 kg/m 2 . The daily dose of YY-312 was 2400 mg (containing 1800 mg of active herbal extract and 600 mg of cyclodextrin). Primary outcomes were reductions in body fat mass (BFM) and body fat percentage (BF%) after 12 weeks. Secondary outcomes included reductions in body weight and waist circumference (WC) after 12 weeks. After 12 weeks, BFM (1.6 kg vs. 0.1 kg; P = 0.023) and BF% (1.5% vs. -0.2%; P = 0.018) decreased significantly more in the YY-312 group than in the placebo group, as did body weight (2.7 kg vs. 1.0 kg; P = 0.014) and WC (2.2 cm vs. 0.8 cm; P = 0.049). All safety parameters were within normal limits; no serious adverse events occurred in either group. In a 12-week clinical trial in overweight adults, YY-312 resulted in significantly greater reduction in body fat vs. placebo, while being safe and well tolerated. cris.nih.go.kr: ( KCT0001225 ).

  10. Parallel computation for solving the tridiagonal linear system of equations

    International Nuclear Information System (INIS)

    Ishiguro, Misako; Harada, Hiroo; Fujii, Minoru; Fujimura, Toichiro; Nakamura, Yasuhiro; Nanba, Katsumi.

    1981-09-01

    Recently, applications of parallel computation for scientific calculations have increased from the need of the high speed calculation of large scale programs. At the JAERI computing center, an array processor FACOM 230-75 APU has installed to study the applicability of parallel computation for nuclear codes. We made some numerical experiments by using the APU on the methods of solution of tridiagonal linear equation which is an important problem in scientific calculations. Referring to the recent papers with parallel methods, we investigate eight ones. These are Gauss elimination method, Parallel Gauss method, Accelerated parallel Gauss method, Jacobi method, Recursive doubling method, Cyclic reduction method, Chebyshev iteration method, and Conjugate gradient method. The computing time and accuracy were compared among the methods on the basis of the numerical experiments. As the result, it is found that the Cyclic reduction method is best both in computing time and accuracy and the Gauss elimination method is the second one. (author)

  11. Parallel grid population

    Science.gov (United States)

    Wald, Ingo; Ize, Santiago

    2015-07-28

    Parallel population of a grid with a plurality of objects using a plurality of processors. One example embodiment is a method for parallel population of a grid with a plurality of objects using a plurality of processors. The method includes a first act of dividing a grid into n distinct grid portions, where n is the number of processors available for populating the grid. The method also includes acts of dividing a plurality of objects into n distinct sets of objects, assigning a distinct set of objects to each processor such that each processor determines by which distinct grid portion(s) each object in its distinct set of objects is at least partially bounded, and assigning a distinct grid portion to each processor such that each processor populates its distinct grid portion with any objects that were previously determined to be at least partially bounded by its distinct grid portion.

  12. Ultrascalable petaflop parallel supercomputer

    Science.gov (United States)

    Blumrich, Matthias A [Ridgefield, CT; Chen, Dong [Croton On Hudson, NY; Chiu, George [Cross River, NY; Cipolla, Thomas M [Katonah, NY; Coteus, Paul W [Yorktown Heights, NY; Gara, Alan G [Mount Kisco, NY; Giampapa, Mark E [Irvington, NY; Hall, Shawn [Pleasantville, NY; Haring, Rudolf A [Cortlandt Manor, NY; Heidelberger, Philip [Cortlandt Manor, NY; Kopcsay, Gerard V [Yorktown Heights, NY; Ohmacht, Martin [Yorktown Heights, NY; Salapura, Valentina [Chappaqua, NY; Sugavanam, Krishnan [Mahopac, NY; Takken, Todd [Brewster, NY

    2010-07-20

    A massively parallel supercomputer of petaOPS-scale includes node architectures based upon System-On-a-Chip technology, where each processing node comprises a single Application Specific Integrated Circuit (ASIC) having up to four processing elements. The ASIC nodes are interconnected by multiple independent networks that optimally maximize the throughput of packet communications between nodes with minimal latency. The multiple networks may include three high-speed networks for parallel algorithm message passing including a Torus, collective network, and a Global Asynchronous network that provides global barrier and notification functions. These multiple independent networks may be collaboratively or independently utilized according to the needs or phases of an algorithm for optimizing algorithm processing performance. The use of a DMA engine is provided to facilitate message passing among the nodes without the expenditure of processing resources at the node.

  13. More parallel please

    DEFF Research Database (Denmark)

    Gregersen, Frans; Josephson, Olle; Kristoffersen, Gjert

    of departure that English may be used in parallel with the various local, in this case Nordic, languages. As such, the book integrates the challenge of internationalization faced by any university with the wish to improve quality in research, education and administration based on the local language......Abstract [en] More parallel, please is the result of the work of an Inter-Nordic group of experts on language policy financed by the Nordic Council of Ministers 2014-17. The book presents all that is needed to plan, practice and revise a university language policy which takes as its point......(s). There are three layers in the text: First, you may read the extremely brief version of the in total 11 recommendations for best practice. Second, you may acquaint yourself with the extended version of the recommendations and finally, you may study the reasoning behind each of them. At the end of the text, we give...

  14. PARALLEL MOVING MECHANICAL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Florian Ion Tiberius Petrescu

    2014-09-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Moving mechanical systems parallel structures are solid, fast, and accurate. Between parallel systems it is to be noticed Stewart platforms, as the oldest systems, fast, solid and precise. The work outlines a few main elements of Stewart platforms. Begin with the geometry platform, kinematic elements of it, and presented then and a few items of dynamics. Dynamic primary element on it means the determination mechanism kinetic energy of the entire Stewart platforms. It is then in a record tail cinematic mobile by a method dot matrix of rotation. If a structural mottoelement consists of two moving elements which translates relative, drive train and especially dynamic it is more convenient to represent the mottoelement as a single moving components. We have thus seven moving parts (the six motoelements or feet to which is added mobile platform 7 and one fixed.

  15. Xyce parallel electronic simulator.

    Energy Technology Data Exchange (ETDEWEB)

    Keiter, Eric R; Mei, Ting; Russo, Thomas V.; Rankin, Eric Lamont; Schiek, Richard Louis; Thornquist, Heidi K.; Fixel, Deborah A.; Coffey, Todd S; Pawlowski, Roger P; Santarelli, Keith R.

    2010-05-01

    This document is a reference guide to the Xyce Parallel Electronic Simulator, and is a companion document to the Xyce Users Guide. The focus of this document is (to the extent possible) exhaustively list device parameters, solver options, parser options, and other usage details of Xyce. This document is not intended to be a tutorial. Users who are new to circuit simulation are better served by the Xyce Users Guide.

  16. Stability of parallel flows

    CERN Document Server

    Betchov, R

    2012-01-01

    Stability of Parallel Flows provides information pertinent to hydrodynamical stability. This book explores the stability problems that occur in various fields, including electronics, mechanics, oceanography, administration, economics, as well as naval and aeronautical engineering. Organized into two parts encompassing 10 chapters, this book starts with an overview of the general equations of a two-dimensional incompressible flow. This text then explores the stability of a laminar boundary layer and presents the equation of the inviscid approximation. Other chapters present the general equation

  17. Algorithmically specialized parallel computers

    CERN Document Server

    Snyder, Lawrence; Gannon, Dennis B

    1985-01-01

    Algorithmically Specialized Parallel Computers focuses on the concept and characteristics of an algorithmically specialized computer.This book discusses the algorithmically specialized computers, algorithmic specialization using VLSI, and innovative architectures. The architectures and algorithms for digital signal, speech, and image processing and specialized architectures for numerical computations are also elaborated. Other topics include the model for analyzing generalized inter-processor, pipelined architecture for search tree maintenance, and specialized computer organization for raster

  18. Resistor Combinations for Parallel Circuits.

    Science.gov (United States)

    McTernan, James P.

    1978-01-01

    To help simplify both teaching and learning of parallel circuits, a high school electricity/electronics teacher presents and illustrates the use of tables of values for parallel resistive circuits in which total resistances are whole numbers. (MF)

  19. SOFTWARE FOR DESIGNING PARALLEL APPLICATIONS

    Directory of Open Access Journals (Sweden)

    M. K. Bouza

    2017-01-01

    Full Text Available The object of research is the tools to support the development of parallel programs in C/C ++. The methods and software which automates the process of designing parallel applications are proposed.

  20. Parallel External Memory Graph Algorithms

    DEFF Research Database (Denmark)

    Arge, Lars Allan; Goodrich, Michael T.; Sitchinava, Nodari

    2010-01-01

    In this paper, we study parallel I/O efficient graph algorithms in the Parallel External Memory (PEM) model, one o f the private-cache chip multiprocessor (CMP) models. We study the fundamental problem of list ranking which leads to efficient solutions to problems on trees, such as computing lowest...... an optimal speedup of ¿(P) in parallel I/O complexity and parallel computation time, compared to the single-processor external memory counterparts....

  1. Parallel inter channel interaction mechanisms

    International Nuclear Information System (INIS)

    Jovic, V.; Afgan, N.; Jovic, L.

    1995-01-01

    Parallel channels interactions are examined. For experimental researches of nonstationary regimes flow in three parallel vertical channels results of phenomenon analysis and mechanisms of parallel channel interaction for adiabatic condition of one-phase fluid and two-phase mixture flow are shown. (author)

  2. 6j-symbols for symmetric representations of SO(n) as the double series

    International Nuclear Information System (INIS)

    Alisauskas, Sigitas

    2002-01-01

    The corrected triple sum expression of Alisauskas (1987 J. Phys. A: Math. Gen. 20 35) for the recoupling (Racah) coefficients (6j-symbols) of the symmetric (most degenerate) representations of the orthogonal groups SO(n) (previously derived from the fourfold sum expression of Alisauskas also related to the result of Hormess and Junker (1999 J. Phys. A: Math. Gen. 32 4249) is rearranged into three new different double sum expressions (related to the hypergeometric Kampe de Feriet type series) and a new triple sum expression with preferable summation condition. The Regge type symmetry of special 6j-symbols of the orthogonal groups SO(n) in terms of special Kampe de Feriet F 1:4 1:3 series is revealed. The recoupling coefficients for antisymmetric representations of symplectic group Sp(2n) are derived using their relation with the recoupling coefficients of the formal orthogonal group SO(-2n)

  3. Massively Parallel QCD

    International Nuclear Information System (INIS)

    Soltz, R; Vranas, P; Blumrich, M; Chen, D; Gara, A; Giampap, M; Heidelberger, P; Salapura, V; Sexton, J; Bhanot, G

    2007-01-01

    The theory of the strong nuclear force, Quantum Chromodynamics (QCD), can be numerically simulated from first principles on massively-parallel supercomputers using the method of Lattice Gauge Theory. We describe the special programming requirements of lattice QCD (LQCD) as well as the optimal supercomputer hardware architectures that it suggests. We demonstrate these methods on the BlueGene massively-parallel supercomputer and argue that LQCD and the BlueGene architecture are a natural match. This can be traced to the simple fact that LQCD is a regular lattice discretization of space into lattice sites while the BlueGene supercomputer is a discretization of space into compute nodes, and that both are constrained by requirements of locality. This simple relation is both technologically important and theoretically intriguing. The main result of this paper is the speedup of LQCD using up to 131,072 CPUs on the largest BlueGene/L supercomputer. The speedup is perfect with sustained performance of about 20% of peak. This corresponds to a maximum of 70.5 sustained TFlop/s. At these speeds LQCD and BlueGene are poised to produce the next generation of strong interaction physics theoretical results

  4. A Parallel Butterfly Algorithm

    KAUST Repository

    Poulson, Jack; Demanet, Laurent; Maxwell, Nicholas; Ying, Lexing

    2014-01-01

    The butterfly algorithm is a fast algorithm which approximately evaluates a discrete analogue of the integral transform (Equation Presented.) at large numbers of target points when the kernel, K(x, y), is approximately low-rank when restricted to subdomains satisfying a certain simple geometric condition. In d dimensions with O(Nd) quasi-uniformly distributed source and target points, when each appropriate submatrix of K is approximately rank-r, the running time of the algorithm is at most O(r2Nd logN). A parallelization of the butterfly algorithm is introduced which, assuming a message latency of α and per-process inverse bandwidth of β, executes in at most (Equation Presented.) time using p processes. This parallel algorithm was then instantiated in the form of the open-source DistButterfly library for the special case where K(x, y) = exp(iΦ(x, y)), where Φ(x, y) is a black-box, sufficiently smooth, real-valued phase function. Experiments on Blue Gene/Q demonstrate impressive strong-scaling results for important classes of phase functions. Using quasi-uniform sources, hyperbolic Radon transforms, and an analogue of a three-dimensional generalized Radon transform were, respectively, observed to strong-scale from 1-node/16-cores up to 1024-nodes/16,384-cores with greater than 90% and 82% efficiency, respectively. © 2014 Society for Industrial and Applied Mathematics.

  5. A Parallel Butterfly Algorithm

    KAUST Repository

    Poulson, Jack

    2014-02-04

    The butterfly algorithm is a fast algorithm which approximately evaluates a discrete analogue of the integral transform (Equation Presented.) at large numbers of target points when the kernel, K(x, y), is approximately low-rank when restricted to subdomains satisfying a certain simple geometric condition. In d dimensions with O(Nd) quasi-uniformly distributed source and target points, when each appropriate submatrix of K is approximately rank-r, the running time of the algorithm is at most O(r2Nd logN). A parallelization of the butterfly algorithm is introduced which, assuming a message latency of α and per-process inverse bandwidth of β, executes in at most (Equation Presented.) time using p processes. This parallel algorithm was then instantiated in the form of the open-source DistButterfly library for the special case where K(x, y) = exp(iΦ(x, y)), where Φ(x, y) is a black-box, sufficiently smooth, real-valued phase function. Experiments on Blue Gene/Q demonstrate impressive strong-scaling results for important classes of phase functions. Using quasi-uniform sources, hyperbolic Radon transforms, and an analogue of a three-dimensional generalized Radon transform were, respectively, observed to strong-scale from 1-node/16-cores up to 1024-nodes/16,384-cores with greater than 90% and 82% efficiency, respectively. © 2014 Society for Industrial and Applied Mathematics.

  6. Fast parallel event reconstruction

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    On-line processing of large data volumes produced in modern HEP experiments requires using maximum capabilities of modern and future many-core CPU and GPU architectures.One of such powerful feature is a SIMD instruction set, which allows packing several data items in one register and to operate on all of them, thus achievingmore operations per clock cycle. Motivated by the idea of using the SIMD unit ofmodern processors, the KF based track fit has been adapted for parallelism, including memory optimization, numerical analysis, vectorization with inline operator overloading, and optimization using SDKs. The speed of the algorithm has been increased in 120000 times with 0.1 ms/track, running in parallel on 16 SPEs of a Cell Blade computer.  Running on a Nehalem CPU with 8 cores it shows the processing speed of 52 ns/track using the Intel Threading Building Blocks. The same KF algorithm running on an Nvidia GTX 280 in the CUDA frameworkprovi...

  7. Parallel Computing in SCALE

    International Nuclear Information System (INIS)

    DeHart, Mark D.; Williams, Mark L.; Bowman, Stephen M.

    2010-01-01

    The SCALE computational architecture has remained basically the same since its inception 30 years ago, although constituent modules and capabilities have changed significantly. This SCALE concept was intended to provide a framework whereby independent codes can be linked to provide a more comprehensive capability than possible with the individual programs - allowing flexibility to address a wide variety of applications. However, the current system was designed originally for mainframe computers with a single CPU and with significantly less memory than today's personal computers. It has been recognized that the present SCALE computation system could be restructured to take advantage of modern hardware and software capabilities, while retaining many of the modular features of the present system. Preliminary work is being done to define specifications and capabilities for a more advanced computational architecture. This paper describes the state of current SCALE development activities and plans for future development. With the release of SCALE 6.1 in 2010, a new phase of evolutionary development will be available to SCALE users within the TRITON and NEWT modules. The SCALE (Standardized Computer Analyses for Licensing Evaluation) code system developed by Oak Ridge National Laboratory (ORNL) provides a comprehensive and integrated package of codes and nuclear data for a wide range of applications in criticality safety, reactor physics, shielding, isotopic depletion and decay, and sensitivity/uncertainty (S/U) analysis. Over the last three years, since the release of version 5.1 in 2006, several important new codes have been introduced within SCALE, and significant advances applied to existing codes. Many of these new features became available with the release of SCALE 6.0 in early 2009. However, beginning with SCALE 6.1, a first generation of parallel computing is being introduced. In addition to near-term improvements, a plan for longer term SCALE enhancement

  8. (Non)local Hamiltonian and symplectic structures, recursions and hierarchies: a new approach and applications to the N = 1 supersymmetric KdV equation

    International Nuclear Information System (INIS)

    Kersten, P; Krasil'shchik, I; Verbovetsky, A

    2004-01-01

    Using methods of Kersten et al (2004 J. Geom. Phys. 50 273-302) and Krasil'shchik and Kersten (2000 Symmetries and Recursion Operators for Classical and Supersymmetric Differential Equations (Dordrecht: Kluwer)), we accomplish an extensive study of the N = 1 supersymmetric Korteweg-de Vries (KdV) equation. The results include a description of local and nonlocal Hamiltonian and symplectic structures, five hierarchies of symmetries, the corresponding hierarchies of conservation laws, recursion operators for symmetries and generating functions of conservation laws. We stress that the main point of the paper is not just the results on super-KdV equation itself, but merely exposition of the efficiency of the geometrical approach and of the computational algorithms based on it

  9. Parallel Polarization State Generation.

    Science.gov (United States)

    She, Alan; Capasso, Federico

    2016-05-17

    The control of polarization, an essential property of light, is of wide scientific and technological interest. The general problem of generating arbitrary time-varying states of polarization (SOP) has always been mathematically formulated by a series of linear transformations, i.e. a product of matrices, imposing a serial architecture. Here we show a parallel architecture described by a sum of matrices. The theory is experimentally demonstrated by modulating spatially-separated polarization components of a laser using a digital micromirror device that are subsequently beam combined. This method greatly expands the parameter space for engineering devices that control polarization. Consequently, performance characteristics, such as speed, stability, and spectral range, are entirely dictated by the technologies of optical intensity modulation, including absorption, reflection, emission, and scattering. This opens up important prospects for polarization state generation (PSG) with unique performance characteristics with applications in spectroscopic ellipsometry, spectropolarimetry, communications, imaging, and security.

  10. Parallel imaging microfluidic cytometer.

    Science.gov (United States)

    Ehrlich, Daniel J; McKenna, Brian K; Evans, James G; Belkina, Anna C; Denis, Gerald V; Sherr, David H; Cheung, Man Ching

    2011-01-01

    By adding an additional degree of freedom from multichannel flow, the parallel microfluidic cytometer (PMC) combines some of the best features of fluorescence-activated flow cytometry (FCM) and microscope-based high-content screening (HCS). The PMC (i) lends itself to fast processing of large numbers of samples, (ii) adds a 1D imaging capability for intracellular localization assays (HCS), (iii) has a high rare-cell sensitivity, and (iv) has an unusual capability for time-synchronized sampling. An inability to practically handle large sample numbers has restricted applications of conventional flow cytometers and microscopes in combinatorial cell assays, network biology, and drug discovery. The PMC promises to relieve a bottleneck in these previously constrained applications. The PMC may also be a powerful tool for finding rare primary cells in the clinic. The multichannel architecture of current PMC prototypes allows 384 unique samples for a cell-based screen to be read out in ∼6-10 min, about 30 times the speed of most current FCM systems. In 1D intracellular imaging, the PMC can obtain protein localization using HCS marker strategies at many times for the sample throughput of charge-coupled device (CCD)-based microscopes or CCD-based single-channel flow cytometers. The PMC also permits the signal integration time to be varied over a larger range than is practical in conventional flow cytometers. The signal-to-noise advantages are useful, for example, in counting rare positive cells in the most difficult early stages of genome-wide screening. We review the status of parallel microfluidic cytometry and discuss some of the directions the new technology may take. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Double inflation

    International Nuclear Information System (INIS)

    Silk, J.; Turner, M.S.

    1986-04-01

    The Zel'dovich spectrum of adiabatic density perturbations is a generic prediction of inflation. There is increasing evidence that when the spectrum is normalized by observational data on small scales, there is not enough power on large scales to account for the observed large-scale structure in the Universe. Decoupling the spectrum on large and small scales could solve this problem. As a means of decoupling the large and small scales we propose double inflation (i.e., two episodes of inflation). In this scenario the spectrum on large scales is determined by the first episode of inflation and those on small scales by a second episode of inflation. We present three models for such a scenario. By nearly saturating the large angular-scale cosmic microwave anisotropy bound, we can easily account for the observed large-scale structure. We take the perturbations on small scales to be very large, deltarho/rho approx. = 0.1 to 0.01, which results in the production of primordial black holes (PBHs), early formation of structure, reionization of the Universe, and a rich array of astrophysical events. The Ω-problem is also addressed by our scenario. Allowing the density perturbations produced by the second episode of inflation to be large also lessens the fine-tuning required in the scalar potential and makes reheating much easier. We briefly speculate on the possibility that the second episode of inflation proceeds through the nucleation of bubbles, which today manifest themselves as empty bubbles whose surfaces are covered with galaxies. 37 refs., 1 fig

  12. Double Outlet Right Ventricle

    Science.gov (United States)

    ... Right Ventricle Menu Topics Topics FAQs Double Outlet Right Ventricle Double outlet right ventricle (DORV) is a rare form of congenital heart disease. En español Double outlet right ventricle (DORV) is a rare form of congenital ...

  13. About Parallel Programming: Paradigms, Parallel Execution and Collaborative Systems

    Directory of Open Access Journals (Sweden)

    Loredana MOCEAN

    2009-01-01

    Full Text Available In the last years, there were made efforts for delineation of a stabile and unitary frame, where the problems of logical parallel processing must find solutions at least at the level of imperative languages. The results obtained by now are not at the level of the made efforts. This paper wants to be a little contribution at these efforts. We propose an overview in parallel programming, parallel execution and collaborative systems.

  14. Parallel Framework for Cooperative Processes

    Directory of Open Access Journals (Sweden)

    Mitică Craus

    2005-01-01

    Full Text Available This paper describes the work of an object oriented framework designed to be used in the parallelization of a set of related algorithms. The idea behind the system we are describing is to have a re-usable framework for running several sequential algorithms in a parallel environment. The algorithms that the framework can be used with have several things in common: they have to run in cycles and the work should be possible to be split between several "processing units". The parallel framework uses the message-passing communication paradigm and is organized as a master-slave system. Two applications are presented: an Ant Colony Optimization (ACO parallel algorithm for the Travelling Salesman Problem (TSP and an Image Processing (IP parallel algorithm for the Symmetrical Neighborhood Filter (SNF. The implementations of these applications by means of the parallel framework prove to have good performances: approximatively linear speedup and low communication cost.

  15. Double hard scattering without double counting

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Gaunt, Jonathan R. [VU Univ. Amsterdam (Netherlands). NIKHEF Theory Group; Schoenwald, Kay [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2017-02-15

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  16. Double hard scattering without double counting

    International Nuclear Information System (INIS)

    Diehl, Markus; Gaunt, Jonathan R.

    2017-02-01

    Double parton scattering in proton-proton collisions includes kinematic regions in which two partons inside a proton originate from the perturbative splitting of a single parton. This leads to a double counting problem between single and double hard scattering. We present a solution to this problem, which allows for the definition of double parton distributions as operator matrix elements in a proton, and which can be used at higher orders in perturbation theory. We show how the evaluation of double hard scattering in this framework can provide a rough estimate for the size of the higher-order contributions to single hard scattering that are affected by double counting. In a numeric study, we identify situations in which these higher-order contributions must be explicitly calculated and included if one wants to attain an accuracy at which double hard scattering becomes relevant, and other situations where such contributions may be neglected.

  17. Parallel Monte Carlo reactor neutronics

    International Nuclear Information System (INIS)

    Blomquist, R.N.; Brown, F.B.

    1994-01-01

    The issues affecting implementation of parallel algorithms for large-scale engineering Monte Carlo neutron transport simulations are discussed. For nuclear reactor calculations, these include load balancing, recoding effort, reproducibility, domain decomposition techniques, I/O minimization, and strategies for different parallel architectures. Two codes were parallelized and tested for performance. The architectures employed include SIMD, MIMD-distributed memory, and workstation network with uneven interactive load. Speedups linear with the number of nodes were achieved

  18. Anti-parallel triplexes

    DEFF Research Database (Denmark)

    Kosbar, Tamer R.; Sofan, Mamdouh A.; Waly, Mohamed A.

    2015-01-01

    about 6.1 °C when the TFO strand was modified with Z and the Watson-Crick strand with adenine-LNA (AL). The molecular modeling results showed that, in case of nucleobases Y and Z a hydrogen bond (1.69 and 1.72 Å, respectively) was formed between the protonated 3-aminopropyn-1-yl chain and one...... of the phosphate groups in Watson-Crick strand. Also, it was shown that the nucleobase Y made a good stacking and binding with the other nucleobases in the TFO and Watson-Crick duplex, respectively. In contrast, the nucleobase Z with LNA moiety was forced to twist out of plane of Watson-Crick base pair which......The phosphoramidites of DNA monomers of 7-(3-aminopropyn-1-yl)-8-aza-7-deazaadenine (Y) and 7-(3-aminopropyn-1-yl)-8-aza-7-deazaadenine LNA (Z) are synthesized, and the thermal stability at pH 7.2 and 8.2 of anti-parallel triplexes modified with these two monomers is determined. When, the anti...

  19. Parallel consensual neural networks.

    Science.gov (United States)

    Benediktsson, J A; Sveinsson, J R; Ersoy, O K; Swain, P H

    1997-01-01

    A new type of a neural-network architecture, the parallel consensual neural network (PCNN), is introduced and applied in classification/data fusion of multisource remote sensing and geographic data. The PCNN architecture is based on statistical consensus theory and involves using stage neural networks with transformed input data. The input data are transformed several times and the different transformed data are used as if they were independent inputs. The independent inputs are first classified using the stage neural networks. The output responses from the stage networks are then weighted and combined to make a consensual decision. In this paper, optimization methods are used in order to weight the outputs from the stage networks. Two approaches are proposed to compute the data transforms for the PCNN, one for binary data and another for analog data. The analog approach uses wavelet packets. The experimental results obtained with the proposed approach show that the PCNN outperforms both a conjugate-gradient backpropagation neural network and conventional statistical methods in terms of overall classification accuracy of test data.

  20. A Parallel Particle Swarm Optimizer

    National Research Council Canada - National Science Library

    Schutte, J. F; Fregly, B .J; Haftka, R. T; George, A. D

    2003-01-01

    .... Motivated by a computationally demanding biomechanical system identification problem, we introduce a parallel implementation of a stochastic population based global optimizer, the Particle Swarm...

  1. Patterns for Parallel Software Design

    CERN Document Server

    Ortega-Arjona, Jorge Luis

    2010-01-01

    Essential reading to understand patterns for parallel programming Software patterns have revolutionized the way we think about how software is designed, built, and documented, and the design of parallel software requires you to consider other particular design aspects and special skills. From clusters to supercomputers, success heavily depends on the design skills of software developers. Patterns for Parallel Software Design presents a pattern-oriented software architecture approach to parallel software design. This approach is not a design method in the classic sense, but a new way of managin

  2. Seeing or moving in parallel

    DEFF Research Database (Denmark)

    Christensen, Mark Schram; Ehrsson, H Henrik; Nielsen, Jens Bo

    2013-01-01

    a different network, involving bilateral dorsal premotor cortex (PMd), primary motor cortex, and SMA, was more active when subjects viewed parallel movements while performing either symmetrical or parallel movements. Correlations between behavioral instability and brain activity were present in right lateral...... adduction-abduction movements symmetrically or in parallel with real-time congruent or incongruent visual feedback of the movements. One network, consisting of bilateral superior and middle frontal gyrus and supplementary motor area (SMA), was more active when subjects performed parallel movements, whereas...

  3. PARALLEL IMPORT: REALITY FOR RUSSIA

    Directory of Open Access Journals (Sweden)

    Т. А. Сухопарова

    2014-01-01

    Full Text Available Problem of parallel import is urgent question at now. Parallel import legalization in Russia is expedient. Such statement based on opposite experts opinion analysis. At the same time it’s necessary to negative consequences consider of this decision and to apply remedies to its minimization.Purchase on Elibrary.ru > Buy now

  4. The Galley Parallel File System

    Science.gov (United States)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    Most current multiprocessor file systems are designed to use multiple disks in parallel, using the high aggregate bandwidth to meet the growing I/0 requirements of parallel scientific applications. Many multiprocessor file systems provide applications with a conventional Unix-like interface, allowing the application to access multiple disks transparently. This interface conceals the parallelism within the file system, increasing the ease of programmability, but making it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. In addition to providing an insufficient interface, most current multiprocessor file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic scientific multiprocessor workloads. We discuss Galley's file structure and application interface, as well as the performance advantages offered by that interface.

  5. Parallelization of the FLAPW method

    International Nuclear Information System (INIS)

    Canning, A.; Mannstadt, W.; Freeman, A.J.

    1999-01-01

    The FLAPW (full-potential linearized-augmented plane-wave) method is one of the most accurate first-principles methods for determining electronic and magnetic properties of crystals and surfaces. Until the present work, the FLAPW method has been limited to systems of less than about one hundred atoms due to a lack of an efficient parallel implementation to exploit the power and memory of parallel computers. In this work we present an efficient parallelization of the method by division among the processors of the plane-wave components for each state. The code is also optimized for RISC (reduced instruction set computer) architectures, such as those found on most parallel computers, making full use of BLAS (basic linear algebra subprograms) wherever possible. Scaling results are presented for systems of up to 686 silicon atoms and 343 palladium atoms per unit cell, running on up to 512 processors on a CRAY T3E parallel computer

  6. Parallelization of the FLAPW method

    Science.gov (United States)

    Canning, A.; Mannstadt, W.; Freeman, A. J.

    2000-08-01

    The FLAPW (full-potential linearized-augmented plane-wave) method is one of the most accurate first-principles methods for determining structural, electronic and magnetic properties of crystals and surfaces. Until the present work, the FLAPW method has been limited to systems of less than about a hundred atoms due to the lack of an efficient parallel implementation to exploit the power and memory of parallel computers. In this work, we present an efficient parallelization of the method by division among the processors of the plane-wave components for each state. The code is also optimized for RISC (reduced instruction set computer) architectures, such as those found on most parallel computers, making full use of BLAS (basic linear algebra subprograms) wherever possible. Scaling results are presented for systems of up to 686 silicon atoms and 343 palladium atoms per unit cell, running on up to 512 processors on a CRAY T3E parallel supercomputer.

  7. Is Monte Carlo embarrassingly parallel?

    Energy Technology Data Exchange (ETDEWEB)

    Hoogenboom, J. E. [Delft Univ. of Technology, Mekelweg 15, 2629 JB Delft (Netherlands); Delft Nuclear Consultancy, IJsselzoom 2, 2902 LB Capelle aan den IJssel (Netherlands)

    2012-07-01

    Monte Carlo is often stated as being embarrassingly parallel. However, running a Monte Carlo calculation, especially a reactor criticality calculation, in parallel using tens of processors shows a serious limitation in speedup and the execution time may even increase beyond a certain number of processors. In this paper the main causes of the loss of efficiency when using many processors are analyzed using a simple Monte Carlo program for criticality. The basic mechanism for parallel execution is MPI. One of the bottlenecks turn out to be the rendez-vous points in the parallel calculation used for synchronization and exchange of data between processors. This happens at least at the end of each cycle for fission source generation in order to collect the full fission source distribution for the next cycle and to estimate the effective multiplication factor, which is not only part of the requested results, but also input to the next cycle for population control. Basic improvements to overcome this limitation are suggested and tested. Also other time losses in the parallel calculation are identified. Moreover, the threading mechanism, which allows the parallel execution of tasks based on shared memory using OpenMP, is analyzed in detail. Recommendations are given to get the maximum efficiency out of a parallel Monte Carlo calculation. (authors)

  8. Is Monte Carlo embarrassingly parallel?

    International Nuclear Information System (INIS)

    Hoogenboom, J. E.

    2012-01-01

    Monte Carlo is often stated as being embarrassingly parallel. However, running a Monte Carlo calculation, especially a reactor criticality calculation, in parallel using tens of processors shows a serious limitation in speedup and the execution time may even increase beyond a certain number of processors. In this paper the main causes of the loss of efficiency when using many processors are analyzed using a simple Monte Carlo program for criticality. The basic mechanism for parallel execution is MPI. One of the bottlenecks turn out to be the rendez-vous points in the parallel calculation used for synchronization and exchange of data between processors. This happens at least at the end of each cycle for fission source generation in order to collect the full fission source distribution for the next cycle and to estimate the effective multiplication factor, which is not only part of the requested results, but also input to the next cycle for population control. Basic improvements to overcome this limitation are suggested and tested. Also other time losses in the parallel calculation are identified. Moreover, the threading mechanism, which allows the parallel execution of tasks based on shared memory using OpenMP, is analyzed in detail. Recommendations are given to get the maximum efficiency out of a parallel Monte Carlo calculation. (authors)

  9. Parallel integer sorting with medium and fine-scale parallelism

    Science.gov (United States)

    Dagum, Leonardo

    1993-01-01

    Two new parallel integer sorting algorithms, queue-sort and barrel-sort, are presented and analyzed in detail. These algorithms do not have optimal parallel complexity, yet they show very good performance in practice. Queue-sort designed for fine-scale parallel architectures which allow the queueing of multiple messages to the same destination. Barrel-sort is designed for medium-scale parallel architectures with a high message passing overhead. The performance results from the implementation of queue-sort on a Connection Machine CM-2 and barrel-sort on a 128 processor iPSC/860 are given. The two implementations are found to be comparable in performance but not as good as a fully vectorized bucket sort on the Cray YMP.

  10. Template based parallel checkpointing in a massively parallel computer system

    Science.gov (United States)

    Archer, Charles Jens [Rochester, MN; Inglett, Todd Alan [Rochester, MN

    2009-01-13

    A method and apparatus for a template based parallel checkpoint save for a massively parallel super computer system using a parallel variation of the rsync protocol, and network broadcast. In preferred embodiments, the checkpoint data for each node is compared to a template checkpoint file that resides in the storage and that was previously produced. Embodiments herein greatly decrease the amount of data that must be transmitted and stored for faster checkpointing and increased efficiency of the computer system. Embodiments are directed to a parallel computer system with nodes arranged in a cluster with a high speed interconnect that can perform broadcast communication. The checkpoint contains a set of actual small data blocks with their corresponding checksums from all nodes in the system. The data blocks may be compressed using conventional non-lossy data compression algorithms to further reduce the overall checkpoint size.

  11. Néologismes à motivation double

    Directory of Open Access Journals (Sweden)

    Raul LILO

    2007-03-01

    Full Text Available Neology of double motivation constitutes a dynamic phenomenon, which includes several ways of word formation. Worth mentioning are loan words, metaphors, allusions, connotations etc., which evoke two parallel realities. These models of forming neologisms, being directly connected with the cultural knowledge of the interlocutors, are commonly used in political dis-courses, as well as in journalism. It is important to point out that the neologisms of this kind are casual and often bear special argument-related values.

  12. Parallel education: what is it?

    OpenAIRE

    Amos, Michelle Peta

    2017-01-01

    In the history of education it has long been discussed that single-sex and coeducation are the two models of education present in schools. With the introduction of parallel schools over the last 15 years, there has been very little research into this 'new model'. Many people do not understand what it means for a school to be parallel or they confuse a parallel model with co-education, due to the presence of both boys and girls within the one institution. Therefore, the main obj...

  13. Balanced, parallel operation of flashlamps

    International Nuclear Information System (INIS)

    Carder, B.M.; Merritt, B.T.

    1979-01-01

    A new energy store, the Compensated Pulsed Alternator (CPA), promises to be a cost effective substitute for capacitors to drive flashlamps that pump large Nd:glass lasers. Because the CPA is large and discrete, it will be necessary that it drive many parallel flashlamp circuits, presenting a problem in equal current distribution. Current division to +- 20% between parallel flashlamps has been achieved, but this is marginal for laser pumping. A method is presented here that provides equal current sharing to about 1%, and it includes fused protection against short circuit faults. The method was tested with eight parallel circuits, including both open-circuit and short-circuit fault tests

  14. Workspace Analysis for Parallel Robot

    Directory of Open Access Journals (Sweden)

    Ying Sun

    2013-05-01

    Full Text Available As a completely new-type of robot, the parallel robot possesses a lot of advantages that the serial robot does not, such as high rigidity, great load-carrying capacity, small error, high precision, small self-weight/load ratio, good dynamic behavior and easy control, hence its range is extended in using domain. In order to find workspace of parallel mechanism, the numerical boundary-searching algorithm based on the reverse solution of kinematics and limitation of link length has been introduced. This paper analyses position workspace, orientation workspace of parallel robot of the six degrees of freedom. The result shows: It is a main means to increase and decrease its workspace to change the length of branch of parallel mechanism; The radius of the movement platform has no effect on the size of workspace, but will change position of workspace.

  15. "Feeling" Series and Parallel Resistances.

    Science.gov (United States)

    Morse, Robert A.

    1993-01-01

    Equipped with drinking straws and stirring straws, a teacher can help students understand how resistances in electric circuits combine in series and in parallel. Follow-up suggestions are provided. (ZWH)

  16. Parallel encoders for pixel detectors

    International Nuclear Information System (INIS)

    Nikityuk, N.M.

    1991-01-01

    A new method of fast encoding and determining the multiplicity and coordinates of fired pixels is described. A specific example construction of parallel encodes and MCC for n=49 and t=2 is given. 16 refs.; 6 figs.; 2 tabs

  17. Massively Parallel Finite Element Programming

    KAUST Repository

    Heister, Timo

    2010-01-01

    Today\\'s large finite element simulations require parallel algorithms to scale on clusters with thousands or tens of thousands of processor cores. We present data structures and algorithms to take advantage of the power of high performance computers in generic finite element codes. Existing generic finite element libraries often restrict the parallelization to parallel linear algebra routines. This is a limiting factor when solving on more than a few hundreds of cores. We describe routines for distributed storage of all major components coupled with efficient, scalable algorithms. We give an overview of our effort to enable the modern and generic finite element library deal.II to take advantage of the power of large clusters. In particular, we describe the construction of a distributed mesh and develop algorithms to fully parallelize the finite element calculation. Numerical results demonstrate good scalability. © 2010 Springer-Verlag.

  18. Event monitoring of parallel computations

    Directory of Open Access Journals (Sweden)

    Gruzlikov Alexander M.

    2015-06-01

    Full Text Available The paper considers the monitoring of parallel computations for detection of abnormal events. It is assumed that computations are organized according to an event model, and monitoring is based on specific test sequences

  19. Massively Parallel Finite Element Programming

    KAUST Repository

    Heister, Timo; Kronbichler, Martin; Bangerth, Wolfgang

    2010-01-01

    Today's large finite element simulations require parallel algorithms to scale on clusters with thousands or tens of thousands of processor cores. We present data structures and algorithms to take advantage of the power of high performance computers in generic finite element codes. Existing generic finite element libraries often restrict the parallelization to parallel linear algebra routines. This is a limiting factor when solving on more than a few hundreds of cores. We describe routines for distributed storage of all major components coupled with efficient, scalable algorithms. We give an overview of our effort to enable the modern and generic finite element library deal.II to take advantage of the power of large clusters. In particular, we describe the construction of a distributed mesh and develop algorithms to fully parallelize the finite element calculation. Numerical results demonstrate good scalability. © 2010 Springer-Verlag.

  20. The STAPL Parallel Graph Library

    KAUST Repository

    Harshvardhan,

    2013-01-01

    This paper describes the stapl Parallel Graph Library, a high-level framework that abstracts the user from data-distribution and parallelism details and allows them to concentrate on parallel graph algorithm development. It includes a customizable distributed graph container and a collection of commonly used parallel graph algorithms. The library introduces pGraph pViews that separate algorithm design from the container implementation. It supports three graph processing algorithmic paradigms, level-synchronous, asynchronous and coarse-grained, and provides common graph algorithms based on them. Experimental results demonstrate improved scalability in performance and data size over existing graph libraries on more than 16,000 cores and on internet-scale graphs containing over 16 billion vertices and 250 billion edges. © Springer-Verlag Berlin Heidelberg 2013.

  1. Writing parallel programs that work

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Serial algorithms typically run inefficiently on parallel machines. This may sound like an obvious statement, but it is the root cause of why parallel programming is considered to be difficult. The current state of the computer industry is still that almost all programs in existence are serial. This talk will describe the techniques used in the Intel Parallel Studio to provide a developer with the tools necessary to understand the behaviors and limitations of the existing serial programs. Once the limitations are known the developer can refactor the algorithms and reanalyze the resulting programs with the tools in the Intel Parallel Studio to create parallel programs that work. About the speaker Paul Petersen is a Sr. Principal Engineer in the Software and Solutions Group (SSG) at Intel. He received a Ph.D. degree in Computer Science from the University of Illinois in 1993. After UIUC, he was employed at Kuck and Associates, Inc. (KAI) working on auto-parallelizing compiler (KAP), and was involved in th...

  2. Exploiting Symmetry on Parallel Architectures.

    Science.gov (United States)

    Stiller, Lewis Benjamin

    1995-01-01

    This thesis describes techniques for the design of parallel programs that solve well-structured problems with inherent symmetry. Part I demonstrates the reduction of such problems to generalized matrix multiplication by a group-equivariant matrix. Fast techniques for this multiplication are described, including factorization, orbit decomposition, and Fourier transforms over finite groups. Our algorithms entail interaction between two symmetry groups: one arising at the software level from the problem's symmetry and the other arising at the hardware level from the processors' communication network. Part II illustrates the applicability of our symmetry -exploitation techniques by presenting a series of case studies of the design and implementation of parallel programs. First, a parallel program that solves chess endgames by factorization of an associated dihedral group-equivariant matrix is described. This code runs faster than previous serial programs, and discovered it a number of results. Second, parallel algorithms for Fourier transforms for finite groups are developed, and preliminary parallel implementations for group transforms of dihedral and of symmetric groups are described. Applications in learning, vision, pattern recognition, and statistics are proposed. Third, parallel implementations solving several computational science problems are described, including the direct n-body problem, convolutions arising from molecular biology, and some communication primitives such as broadcast and reduce. Some of our implementations ran orders of magnitude faster than previous techniques, and were used in the investigation of various physical phenomena.

  3. Parallel algorithms for continuum dynamics

    International Nuclear Information System (INIS)

    Hicks, D.L.; Liebrock, L.M.

    1987-01-01

    Simply porting existing parallel programs to a new parallel processor may not achieve the full speedup possible; to achieve the maximum efficiency may require redesigning the parallel algorithms for the specific architecture. The authors discuss here parallel algorithms that were developed first for the HEP processor and then ported to the CRAY X-MP/4, the ELXSI/10, and the Intel iPSC/32. Focus is mainly on the most recent parallel processing results produced, i.e., those on the Intel Hypercube. The applications are simulations of continuum dynamics in which the momentum and stress gradients are important. Examples of these are inertial confinement fusion experiments, severe breaks in the coolant system of a reactor, weapons physics, shock-wave physics. Speedup efficiencies on the Intel iPSC Hypercube are very sensitive to the ratio of communication to computation. Great care must be taken in designing algorithms for this machine to avoid global communication. This is much more critical on the iPSC than it was on the three previous parallel processors

  4. International double taxation

    OpenAIRE

    Körbl, Hugo

    2012-01-01

    1 Summary This thesis deals with the issue of international double taxation of income and capital and methods for its solution. International double taxation is an issue which states began to deal with in the late 19th century. This interest intensified after the First World War when also the League of Nations (predecessor of the United Nations) began to deal with international double taxation. Most attention the phenomenon of double taxation of income and capital with an international elemen...

  5. Endpoint-based parallel data processing in a parallel active messaging interface of a parallel computer

    Science.gov (United States)

    Archer, Charles J.; Blocksome, Michael A.; Ratterman, Joseph D.; Smith, Brian E.

    2014-08-12

    Endpoint-based parallel data processing in a parallel active messaging interface (`PAMI`) of a parallel computer, the PAMI composed of data communications endpoints, each endpoint including a specification of data communications parameters for a thread of execution on a compute node, including specifications of a client, a context, and a task, the compute nodes coupled for data communications through the PAMI, including establishing a data communications geometry, the geometry specifying, for tasks representing processes of execution of the parallel application, a set of endpoints that are used in collective operations of the PAMI including a plurality of endpoints for one of the tasks; receiving in endpoints of the geometry an instruction for a collective operation; and executing the instruction for a collective operation through the endpoints in dependence upon the geometry, including dividing data communications operations among the plurality of endpoints for one of the tasks.

  6. The parallel processing of EGS4 code on distributed memory scalar parallel computer:Intel Paragon XP/S15-256

    Energy Technology Data Exchange (ETDEWEB)

    Takemiya, Hiroshi; Ohta, Hirofumi; Honma, Ichirou

    1996-03-01

    The parallelization of Electro-Magnetic Cascade Monte Carlo Simulation Code, EGS4 on distributed memory scalar parallel computer: Intel Paragon XP/S15-256 is described. EGS4 has the feature that calculation time for one incident particle is quite different from each other because of the dynamic generation of secondary particles and different behavior of each particle. Granularity for parallel processing, parallel programming model and the algorithm of parallel random number generation are discussed and two kinds of method, each of which allocates particles dynamically or statically, are used for the purpose of realizing high speed parallel processing of this code. Among four problems chosen for performance evaluation, the speedup factors for three problems have been attained to nearly 100 times with 128 processor. It has been found that when both the calculation time for each incident particles and its dispersion are large, it is preferable to use dynamic particle allocation method which can average the load for each processor. And it has also been found that when they are small, it is preferable to use static particle allocation method which reduces the communication overhead. Moreover, it is pointed out that to get the result accurately, it is necessary to use double precision variables in EGS4 code. Finally, the workflow of program parallelization is analyzed and tools for program parallelization through the experience of the EGS4 parallelization are discussed. (author).

  7. Parallel Implicit Algorithms for CFD

    Science.gov (United States)

    Keyes, David E.

    1998-01-01

    The main goal of this project was efficient distributed parallel and workstation cluster implementations of Newton-Krylov-Schwarz (NKS) solvers for implicit Computational Fluid Dynamics (CFD.) "Newton" refers to a quadratically convergent nonlinear iteration using gradient information based on the true residual, "Krylov" to an inner linear iteration that accesses the Jacobian matrix only through highly parallelizable sparse matrix-vector products, and "Schwarz" to a domain decomposition form of preconditioning the inner Krylov iterations with primarily neighbor-only exchange of data between the processors. Prior experience has established that Newton-Krylov methods are competitive solvers in the CFD context and that Krylov-Schwarz methods port well to distributed memory computers. The combination of the techniques into Newton-Krylov-Schwarz was implemented on 2D and 3D unstructured Euler codes on the parallel testbeds that used to be at LaRC and on several other parallel computers operated by other agencies or made available by the vendors. Early implementations were made directly in Massively Parallel Integration (MPI) with parallel solvers we adapted from legacy NASA codes and enhanced for full NKS functionality. Later implementations were made in the framework of the PETSC library from Argonne National Laboratory, which now includes pseudo-transient continuation Newton-Krylov-Schwarz solver capability (as a result of demands we made upon PETSC during our early porting experiences). A secondary project pursued with funding from this contract was parallel implicit solvers in acoustics, specifically in the Helmholtz formulation. A 2D acoustic inverse problem has been solved in parallel within the PETSC framework.

  8. Second derivative parallel block backward differentiation type ...

    African Journals Online (AJOL)

    Second derivative parallel block backward differentiation type formulas for Stiff ODEs. ... Log in or Register to get access to full text downloads. ... and the methods are inherently parallel and can be distributed over parallel processors. They are ...

  9. A Parallel Approach to Fractal Image Compression

    OpenAIRE

    Lubomir Dedera

    2004-01-01

    The paper deals with a parallel approach to coding and decoding algorithms in fractal image compressionand presents experimental results comparing sequential and parallel algorithms from the point of view of achieved bothcoding and decoding time and effectiveness of parallelization.

  10. Double layers in space

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-07-01

    For more than a decade it has been realised that electrostatic double layers are likely to occur in space. We briefly discuss the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Author)

  11. Double layers in space

    International Nuclear Information System (INIS)

    Carlqvist, P.

    1982-01-01

    For more than a decade it has been realised that electrostatic double layers are likely to occur in space. The author briefly discusses the theoretical background of such double layers. Most of the paper is devoted to an account of the observational evidence for double layers in the ionosphere and magnetosphere of the Earth. Several different experiments are reviewed including rocket and satellite measurements and ground based observations. It is concluded that the observational evidence for double layers in space is very strong. The experimental results indicate that double layers with widely different properties may exist in space. (Auth.)

  12. Double-double effect and coordination number

    International Nuclear Information System (INIS)

    Mioduski, T.

    1992-01-01

    The original method of interpretation together with its theoretical foundations is developed, making it possible to use location and direction of the double-double (tetrad) effect within the Ln and An series to determine the coordination number (CN) complexes of the f-block elements. The method is applied for potentiometric and radiometric equilibrium studies. It has been pointed and that the decisive factor for the direction of the double-double effect in the case of the Gibbs energy variations is a difference in the CN of the f-element ion between the reaction product complex and that for the reaction substrate the ''regular'' effect for a given tetrad is accompanied by decrease in the CN while the ''reverse'' effect by increase in the CN. (author). 122 refs, 5 tabs, 8 figs

  13. Parallel fabrication of macroporous scaffolds.

    Science.gov (United States)

    Dobos, Andrew; Grandhi, Taraka Sai Pavan; Godeshala, Sudhakar; Meldrum, Deirdre R; Rege, Kaushal

    2018-07-01

    Scaffolds generated from naturally occurring and synthetic polymers have been investigated in several applications because of their biocompatibility and tunable chemo-mechanical properties. Existing methods for generation of 3D polymeric scaffolds typically cannot be parallelized, suffer from low throughputs, and do not allow for quick and easy removal of the fragile structures that are formed. Current molds used in hydrogel and scaffold fabrication using solvent casting and porogen leaching are often single-use and do not facilitate 3D scaffold formation in parallel. Here, we describe a simple device and related approaches for the parallel fabrication of macroporous scaffolds. This approach was employed for the generation of macroporous and non-macroporous materials in parallel, in higher throughput and allowed for easy retrieval of these 3D scaffolds once formed. In addition, macroporous scaffolds with interconnected as well as non-interconnected pores were generated, and the versatility of this approach was employed for the generation of 3D scaffolds from diverse materials including an aminoglycoside-derived cationic hydrogel ("Amikagel"), poly(lactic-co-glycolic acid) or PLGA, and collagen. Macroporous scaffolds generated using the device were investigated for plasmid DNA binding and cell loading, indicating the use of this approach for developing materials for different applications in biotechnology. Our results demonstrate that the device-based approach is a simple technology for generating scaffolds in parallel, which can enhance the toolbox of current fabrication techniques. © 2018 Wiley Periodicals, Inc.

  14. Parallel plasma fluid turbulence calculations

    International Nuclear Information System (INIS)

    Leboeuf, J.N.; Carreras, B.A.; Charlton, L.A.; Drake, J.B.; Lynch, V.E.; Newman, D.E.; Sidikman, K.L.; Spong, D.A.

    1994-01-01

    The study of plasma turbulence and transport is a complex problem of critical importance for fusion-relevant plasmas. To this day, the fluid treatment of plasma dynamics is the best approach to realistic physics at the high resolution required for certain experimentally relevant calculations. Core and edge turbulence in a magnetic fusion device have been modeled using state-of-the-art, nonlinear, three-dimensional, initial-value fluid and gyrofluid codes. Parallel implementation of these models on diverse platforms--vector parallel (National Energy Research Supercomputer Center's CRAY Y-MP C90), massively parallel (Intel Paragon XP/S 35), and serial parallel (clusters of high-performance workstations using the Parallel Virtual Machine protocol)--offers a variety of paths to high resolution and significant improvements in real-time efficiency, each with its own advantages. The largest and most efficient calculations have been performed at the 200 Mword memory limit on the C90 in dedicated mode, where an overlap of 12 to 13 out of a maximum of 16 processors has been achieved with a gyrofluid model of core fluctuations. The richness of the physics captured by these calculations is commensurate with the increased resolution and efficiency and is limited only by the ingenuity brought to the analysis of the massive amounts of data generated

  15. Evaluating parallel optimization on transputers

    Directory of Open Access Journals (Sweden)

    A.G. Chalmers

    2003-12-01

    Full Text Available The faster processing power of modern computers and the development of efficient algorithms have made it possible for operations researchers to tackle a much wider range of problems than ever before. Further improvements in processing speed can be achieved utilising relatively inexpensive transputers to process components of an algorithm in parallel. The Davidon-Fletcher-Powell method is one of the most successful and widely used optimisation algorithms for unconstrained problems. This paper examines the algorithm and identifies the components that can be processed in parallel. The results of some experiments with these components are presented which indicates under what conditions parallel processing with an inexpensive configuration is likely to be faster than the traditional sequential implementations. The performance of the whole algorithm with its parallel components is then compared with the original sequential algorithm. The implementation serves to illustrate the practicalities of speeding up typical OR algorithms in terms of difficulty, effort and cost. The results give an indication of the savings in time a given parallel implementation can be expected to yield.

  16. Pattern-Driven Automatic Parallelization

    Directory of Open Access Journals (Sweden)

    Christoph W. Kessler

    1996-01-01

    Full Text Available This article describes a knowledge-based system for automatic parallelization of a wide class of sequential numerical codes operating on vectors and dense matrices, and for execution on distributed memory message-passing multiprocessors. Its main feature is a fast and powerful pattern recognition tool that locally identifies frequently occurring computations and programming concepts in the source code. This tool also works for dusty deck codes that have been "encrypted" by former machine-specific code transformations. Successful pattern recognition guides sophisticated code transformations including local algorithm replacement such that the parallelized code need not emerge from the sequential program structure by just parallelizing the loops. It allows access to an expert's knowledge on useful parallel algorithms, available machine-specific library routines, and powerful program transformations. The partially restored program semantics also supports local array alignment, distribution, and redistribution, and allows for faster and more exact prediction of the performance of the parallelized target code than is usually possible.

  17. Parallel artificial liquid membrane extraction

    DEFF Research Database (Denmark)

    Gjelstad, Astrid; Rasmussen, Knut Einar; Parmer, Marthe Petrine

    2013-01-01

    This paper reports development of a new approach towards analytical liquid-liquid-liquid membrane extraction termed parallel artificial liquid membrane extraction. A donor plate and acceptor plate create a sandwich, in which each sample (human plasma) and acceptor solution is separated by an arti......This paper reports development of a new approach towards analytical liquid-liquid-liquid membrane extraction termed parallel artificial liquid membrane extraction. A donor plate and acceptor plate create a sandwich, in which each sample (human plasma) and acceptor solution is separated...... by an artificial liquid membrane. Parallel artificial liquid membrane extraction is a modification of hollow-fiber liquid-phase microextraction, where the hollow fibers are replaced by flat membranes in a 96-well plate format....

  18. Parallel algorithms for mapping pipelined and parallel computations

    Science.gov (United States)

    Nicol, David M.

    1988-01-01

    Many computational problems in image processing, signal processing, and scientific computing are naturally structured for either pipelined or parallel computation. When mapping such problems onto a parallel architecture it is often necessary to aggregate an obvious problem decomposition. Even in this context the general mapping problem is known to be computationally intractable, but recent advances have been made in identifying classes of problems and architectures for which optimal solutions can be found in polynomial time. Among these, the mapping of pipelined or parallel computations onto linear array, shared memory, and host-satellite systems figures prominently. This paper extends that work first by showing how to improve existing serial mapping algorithms. These improvements have significantly lower time and space complexities: in one case a published O(nm sup 3) time algorithm for mapping m modules onto n processors is reduced to an O(nm log m) time complexity, and its space requirements reduced from O(nm sup 2) to O(m). Run time complexity is further reduced with parallel mapping algorithms based on these improvements, which run on the architecture for which they create the mappings.

  19. Cellular automata a parallel model

    CERN Document Server

    Mazoyer, J

    1999-01-01

    Cellular automata can be viewed both as computational models and modelling systems of real processes. This volume emphasises the first aspect. In articles written by leading researchers, sophisticated massive parallel algorithms (firing squad, life, Fischer's primes recognition) are treated. Their computational power and the specific complexity classes they determine are surveyed, while some recent results in relation to chaos from a new dynamic systems point of view are also presented. Audience: This book will be of interest to specialists of theoretical computer science and the parallelism challenge.

  20. Parallel Sparse Matrix - Vector Product

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Lazarov, Boyan Stefanov; Dammann, Bernd

    This technical report contains a case study of a sparse matrix-vector product routine, implemented for parallel execution on a compute cluster with both pure MPI and hybrid MPI-OpenMP solutions. C++ classes for sparse data types were developed and the report shows how these class can be used...

  1. [Falsified medicines in parallel trade].

    Science.gov (United States)

    Muckenfuß, Heide

    2017-11-01

    The number of falsified medicines on the German market has distinctly increased over the past few years. In particular, stolen pharmaceutical products, a form of falsified medicines, have increasingly been introduced into the legal supply chain via parallel trading. The reasons why parallel trading serves as a gateway for falsified medicines are most likely the complex supply chains and routes of transport. It is hardly possible for national authorities to trace the history of a medicinal product that was bought and sold by several intermediaries in different EU member states. In addition, the heterogeneous outward appearance of imported and relabelled pharmaceutical products facilitates the introduction of illegal products onto the market. Official batch release at the Paul-Ehrlich-Institut offers the possibility of checking some aspects that might provide an indication of a falsified medicine. In some circumstances, this may allow the identification of falsified medicines before they come onto the German market. However, this control is only possible for biomedicinal products that have not received a waiver regarding official batch release. For improved control of parallel trade, better networking among the EU member states would be beneficial. European-wide regulations, e. g., for disclosure of the complete supply chain, would help to minimise the risks of parallel trading and hinder the marketing of falsified medicines.

  2. The parallel adult education system

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2015-01-01

    for competence development. The Danish university educational system includes two parallel programs: a traditional academic track (candidatus) and an alternative practice-based track (master). The practice-based program was established in 2001 and organized as part time. The total program takes half the time...

  3. Where are the parallel algorithms?

    Science.gov (United States)

    Voigt, R. G.

    1985-01-01

    Four paradigms that can be useful in developing parallel algorithms are discussed. These include computational complexity analysis, changing the order of computation, asynchronous computation, and divide and conquer. Each is illustrated with an example from scientific computation, and it is shown that computational complexity must be used with great care or an inefficient algorithm may be selected.

  4. Parallel imaging with phase scrambling.

    Science.gov (United States)

    Zaitsev, Maxim; Schultz, Gerrit; Hennig, Juergen; Gruetter, Rolf; Gallichan, Daniel

    2015-04-01

    Most existing methods for accelerated parallel imaging in MRI require additional data, which are used to derive information about the sensitivity profile of each radiofrequency (RF) channel. In this work, a method is presented to avoid the acquisition of separate coil calibration data for accelerated Cartesian trajectories. Quadratic phase is imparted to the image to spread the signals in k-space (aka phase scrambling). By rewriting the Fourier transform as a convolution operation, a window can be introduced to the convolved chirp function, allowing a low-resolution image to be reconstructed from phase-scrambled data without prominent aliasing. This image (for each RF channel) can be used to derive coil sensitivities to drive existing parallel imaging techniques. As a proof of concept, the quadratic phase was applied by introducing an offset to the x(2) - y(2) shim and the data were reconstructed using adapted versions of the image space-based sensitivity encoding and GeneRalized Autocalibrating Partially Parallel Acquisitions algorithms. The method is demonstrated in a phantom (1 × 2, 1 × 3, and 2 × 2 acceleration) and in vivo (2 × 2 acceleration) using a 3D gradient echo acquisition. Phase scrambling can be used to perform parallel imaging acceleration without acquisition of separate coil calibration data, demonstrated here for a 3D-Cartesian trajectory. Further research is required to prove the applicability to other 2D and 3D sampling schemes. © 2014 Wiley Periodicals, Inc.

  5. Default Parallels Plesk Panel Page

    Science.gov (United States)

    services that small businesses want and need. Our software includes key building blocks of cloud service virtualized servers Service Provider Products Parallels® Automation Hosting, SaaS, and cloud computing , the leading hosting automation software. You see this page because there is no Web site at this

  6. Parallel plate transmission line transformer

    NARCIS (Netherlands)

    Voeten, S.J.; Brussaard, G.J.H.; Pemen, A.J.M.

    2011-01-01

    A Transmission Line Transformer (TLT) can be used to transform high-voltage nanosecond pulses. These transformers rely on the fact that the length of the pulse is shorter than the transmission lines used. This allows connecting the transmission lines in parallel at the input and in series at the

  7. Matpar: Parallel Extensions for MATLAB

    Science.gov (United States)

    Springer, P. L.

    1998-01-01

    Matpar is a set of client/server software that allows a MATLAB user to take advantage of a parallel computer for very large problems. The user can replace calls to certain built-in MATLAB functions with calls to Matpar functions.

  8. Massively parallel quantum computer simulator

    NARCIS (Netherlands)

    De Raedt, K.; Michielsen, K.; De Raedt, H.; Trieu, B.; Arnold, G.; Richter, M.; Lippert, Th.; Watanabe, H.; Ito, N.

    2007-01-01

    We describe portable software to simulate universal quantum computers on massive parallel Computers. We illustrate the use of the simulation software by running various quantum algorithms on different computer architectures, such as a IBM BlueGene/L, a IBM Regatta p690+, a Hitachi SR11000/J1, a Cray

  9. Parallel computing: numerics, applications, and trends

    National Research Council Canada - National Science Library

    Trobec, Roman; Vajteršic, Marián; Zinterhof, Peter

    2009-01-01

    ... and/or distributed systems. The contributions to this book are focused on topics most concerned in the trends of today's parallel computing. These range from parallel algorithmics, programming, tools, network computing to future parallel computing. Particular attention is paid to parallel numerics: linear algebra, differential equations, numerica...

  10. Experiments with parallel algorithms for combinatorial problems

    NARCIS (Netherlands)

    G.A.P. Kindervater (Gerard); H.W.J.M. Trienekens

    1985-01-01

    textabstractIn the last decade many models for parallel computation have been proposed and many parallel algorithms have been developed. However, few of these models have been realized and most of these algorithms are supposed to run on idealized, unrealistic parallel machines. The parallel machines

  11. Parallel R-matrix computation

    International Nuclear Information System (INIS)

    Heggarty, J.W.

    1999-06-01

    For almost thirty years, sequential R-matrix computation has been used by atomic physics research groups, from around the world, to model collision phenomena involving the scattering of electrons or positrons with atomic or molecular targets. As considerable progress has been made in the understanding of fundamental scattering processes, new data, obtained from more complex calculations, is of current interest to experimentalists. Performing such calculations, however, places considerable demands on the computational resources to be provided by the target machine, in terms of both processor speed and memory requirement. Indeed, in some instances the computational requirements are so great that the proposed R-matrix calculations are intractable, even when utilising contemporary classic supercomputers. Historically, increases in the computational requirements of R-matrix computation were accommodated by porting the problem codes to a more powerful classic supercomputer. Although this approach has been successful in the past, it is no longer considered to be a satisfactory solution due to the limitations of current (and future) Von Neumann machines. As a consequence, there has been considerable interest in the high performance multicomputers, that have emerged over the last decade which appear to offer the computational resources required by contemporary R-matrix research. Unfortunately, developing codes for these machines is not as simple a task as it was to develop codes for successive classic supercomputers. The difficulty arises from the considerable differences in the computing models that exist between the two types of machine and results in the programming of multicomputers to be widely acknowledged as a difficult, time consuming and error-prone task. Nevertheless, unless parallel R-matrix computation is realised, important theoretical and experimental atomic physics research will continue to be hindered. This thesis describes work that was undertaken in

  12. A parallel solver for huge dense linear systems

    Science.gov (United States)

    Badia, J. M.; Movilla, J. L.; Climente, J. I.; Castillo, M.; Marqués, M.; Mayo, R.; Quintana-Ortí, E. S.; Planelles, J.

    2011-11-01

    : Linux/Unix Has the code been vectorized or parallelized?: Yes, includes MPI primitives. RAM: Tested for up to 190 GB Classification: 6.5 External routines: MPI ( http://www.mpi-forum.org/), BLAS ( http://www.netlib.org/blas/), PLAPACK ( http://www.cs.utexas.edu/~plapack/), POOCLAPACK ( ftp://ftp.cs.utexas.edu/pub/rvdg/PLAPACK/pooclapack.ps) (code for PLAPACK and POOCLAPACK is included in the distribution). Catalogue identifier of previous version: AEHU_v1_0 Journal reference of previous version: Comput. Phys. Comm. 182 (2011) 533 Does the new version supersede the previous version?: Yes Nature of problem: Huge scale dense systems of linear equations, Ax=B, beyond standard LAPACK capabilities. Solution method: The linear systems are solved by means of parallelized routines based on the LU factorization, using efficient secondary storage algorithms when the available main memory is insufficient. Reasons for new version: In many applications we need to guarantee a high accuracy in the solution of very large linear systems and we can do it by using double-precision arithmetic. Summary of revisions: Version 1.1 Can be used to solve linear systems using double-precision arithmetic. New version of the initialization routine. The user can choose the kind of arithmetic and the values of several parameters of the environment. Running time: About 5 hours to solve a system with more than 200 000 equations and more than 10 000 right-hand side vectors using double-precision arithmetic on an eight-node commodity cluster with a total of 64 Intel cores.

  13. Observing Double Stars

    Science.gov (United States)

    Genet, Russell M.; Fulton, B. J.; Bianco, Federica B.; Martinez, John; Baxter, John; Brewer, Mark; Carro, Joseph; Collins, Sarah; Estrada, Chris; Johnson, Jolyon; Salam, Akash; Wallen, Vera; Warren, Naomi; Smith, Thomas C.; Armstrong, James D.; McGaughey, Steve; Pye, John; Mohanan, Kakkala; Church, Rebecca

    2012-05-01

    Double stars have been systematically observed since William Herschel initiated his program in 1779. In 1803 he reported that, to his surprise, many of the systems he had been observing for a quarter century were gravitationally bound binary stars. In 1830 the first binary orbital solution was obtained, leading eventually to the determination of stellar masses. Double star observations have been a prolific field, with observations and discoveries - often made by students and amateurs - routinely published in a number of specialized journals such as the Journal of Double Star Observations. All published double star observations from Herschel's to the present have been incorporated in the Washington Double Star Catalog. In addition to reviewing the history of visual double stars, we discuss four observational technologies and illustrate these with our own observational results from both California and Hawaii on telescopes ranging from small SCTs to the 2-meter Faulkes Telescope North on Haleakala. Two of these technologies are visual observations aimed primarily at published "hands-on" student science education, and CCD observations of both bright and very faint doubles. The other two are recent technologies that have launched a double star renaissance. These are lucky imaging and speckle interferometry, both of which can use electron-multiplying CCD cameras to allow short (30 ms or less) exposures that are read out at high speed with very low noise. Analysis of thousands of high speed exposures allows normal seeing limitations to be overcome so very close doubles can be accurately measured.

  14. Formation of double layers

    International Nuclear Information System (INIS)

    Leung, P.; Wong, A.Y.; Quon, B.H.

    1981-01-01

    Experiments on both stationary and propagating double layers and a related analytical model are described. Stationary double layers were produced in a multiple plasma device, in which an electron drift current was present. An investigation of the plasma parameters for the stable double layer condition is described. The particle distribution in the stable double layer establishes a potential profile, which creates electron and ion beams that excite plasma instabilities. The measured characteristics of the instabilities are consistent with the existence of the double layer. Propagating double layers are formed when the initial electron drift current is large. Ths slopes of the transition region increase as they propagate. A physical model for the formation of a double layer in the experimental device is described. This model explains the formation of the low potential region on the basis of the space charge. This space charge is created by the electron drift current. The model also accounts for the role of ions in double layer formation and explains the formation of moving double layers. (Auth.)

  15. Oscillatory magnetoconductance of quantum double-well channels

    International Nuclear Information System (INIS)

    Rojo, A.G.; Kumar, N.; Balseiro, C.A.

    1988-07-01

    The recently observed flux-periodic interference effect between parallel quantum double-well channels is theoretically studied in a discrete model that takes into account tunneling between channels. We obtain oscillatory magnetoconductance with small modulations which is attributable to the tunneling. Our treatment includes the effect of evanescent modes. (author). 7 refs, 2 figs

  16. The numerical parallel computing of photon transport

    International Nuclear Information System (INIS)

    Huang Qingnan; Liang Xiaoguang; Zhang Lifa

    1998-12-01

    The parallel computing of photon transport is investigated, the parallel algorithm and the parallelization of programs on parallel computers both with shared memory and with distributed memory are discussed. By analyzing the inherent law of the mathematics and physics model of photon transport according to the structure feature of parallel computers, using the strategy of 'to divide and conquer', adjusting the algorithm structure of the program, dissolving the data relationship, finding parallel liable ingredients and creating large grain parallel subtasks, the sequential computing of photon transport into is efficiently transformed into parallel and vector computing. The program was run on various HP parallel computers such as the HY-1 (PVP), the Challenge (SMP) and the YH-3 (MPP) and very good parallel speedup has been gotten

  17. Parallelization of MRCI based on hole-particle symmetry.

    Science.gov (United States)

    Suo, Bing; Zhai, Gaohong; Wang, Yubin; Wen, Zhenyi; Hu, Xiangqian; Li, Lemin

    2005-01-15

    The parallel implementation of multireference configuration interaction program based on the hole-particle symmetry is described. The platform to implement the parallelization is an Intel-Architectural cluster consisting of 12 nodes, each of which is equipped with two 2.4-G XEON processors, 3-GB memory, and 36-GB disk, and are connected by a Gigabit Ethernet Switch. The dependence of speedup on molecular symmetries and task granularities is discussed. Test calculations show that the scaling with the number of nodes is about 1.9 (for C1 and Cs), 1.65 (for C2v), and 1.55 (for D2h) when the number of nodes is doubled. The largest calculation performed on this cluster involves 5.6 x 10(8) CSFs.

  18. Parallel algorithms for computation of the manipulator inertia matrix

    Science.gov (United States)

    Amin-Javaheri, Masoud; Orin, David E.

    1989-01-01

    The development of an O(log2N) parallel algorithm for the manipulator inertia matrix is presented. It is based on the most efficient serial algorithm which uses the composite rigid body method. Recursive doubling is used to reformulate the linear recurrence equations which are required to compute the diagonal elements of the matrix. It results in O(log2N) levels of computation. Computation of the off-diagonal elements involves N linear recurrences of varying-size and a new method, which avoids redundant computation of position and orientation transforms for the manipulator, is developed. The O(log2N) algorithm is presented in both equation and graphic forms which clearly show the parallelism inherent in the algorithm.

  19. Automatic Parallelization Tool: Classification of Program Code for Parallel Computing

    Directory of Open Access Journals (Sweden)

    Mustafa Basthikodi

    2016-04-01

    Full Text Available Performance growth of single-core processors has come to a halt in the past decade, but was re-enabled by the introduction of parallelism in processors. Multicore frameworks along with Graphical Processing Units empowered to enhance parallelism broadly. Couples of compilers are updated to developing challenges forsynchronization and threading issues. Appropriate program and algorithm classifications will have advantage to a great extent to the group of software engineers to get opportunities for effective parallelization. In present work we investigated current species for classification of algorithms, in that related work on classification is discussed along with the comparison of issues that challenges the classification. The set of algorithms are chosen which matches the structure with different issues and perform given task. We have tested these algorithms utilizing existing automatic species extraction toolsalong with Bones compiler. We have added functionalities to existing tool, providing a more detailed characterization. The contributions of our work include support for pointer arithmetic, conditional and incremental statements, user defined types, constants and mathematical functions. With this, we can retain significant data which is not captured by original speciesof algorithms. We executed new theories into the device, empowering automatic characterization of program code.

  20. Double deflation and aggregation

    NARCIS (Netherlands)

    Dietzenbacher, Erik; Hoen, A.R.

    Published input-output tables in constant prices are relatively scarce. Therefore, input-output tables often have to be deflated by the practitioners themselves. The method of double deflation is used predominantly for this purpose. The present paper shows that the double-deflation method is subject

  1. Structural synthesis of parallel robots

    CERN Document Server

    Gogu, Grigore

    This book represents the fifth part of a larger work dedicated to the structural synthesis of parallel robots. The originality of this work resides in the fact that it combines new formulae for mobility, connectivity, redundancy and overconstraints with evolutionary morphology in a unified structural synthesis approach that yields interesting and innovative solutions for parallel robotic manipulators.  This is the first book on robotics that presents solutions for coupled, decoupled, uncoupled, fully-isotropic and maximally regular robotic manipulators with Schönflies motions systematically generated by using the structural synthesis approach proposed in Part 1.  Overconstrained non-redundant/overactuated/redundantly actuated solutions with simple/complex limbs are proposed. Many solutions are presented here for the first time in the literature. The author had to make a difficult and challenging choice between protecting these solutions through patents and releasing them directly into the public domain. T...

  2. GPU Parallel Bundle Block Adjustment

    Directory of Open Access Journals (Sweden)

    ZHENG Maoteng

    2017-09-01

    Full Text Available To deal with massive data in photogrammetry, we introduce the GPU parallel computing technology. The preconditioned conjugate gradient and inexact Newton method are also applied to decrease the iteration times while solving the normal equation. A brand new workflow of bundle adjustment is developed to utilize GPU parallel computing technology. Our method can avoid the storage and inversion of the big normal matrix, and compute the normal matrix in real time. The proposed method can not only largely decrease the memory requirement of normal matrix, but also largely improve the efficiency of bundle adjustment. It also achieves the same accuracy as the conventional method. Preliminary experiment results show that the bundle adjustment of a dataset with about 4500 images and 9 million image points can be done in only 1.5 minutes while achieving sub-pixel accuracy.

  3. A tandem parallel plate analyzer

    International Nuclear Information System (INIS)

    Hamada, Y.; Fujisawa, A.; Iguchi, H.; Nishizawa, A.; Kawasumi, Y.

    1996-11-01

    By a new modification of a parallel plate analyzer the second-order focus is obtained in an arbitrary injection angle. This kind of an analyzer with a small injection angle will have an advantage of small operational voltage, compared to the Proca and Green analyzer where the injection angle is 30 degrees. Thus, the newly proposed analyzer will be very useful for the precise energy measurement of high energy particles in MeV range. (author)

  4. High-speed parallel counter

    International Nuclear Information System (INIS)

    Gus'kov, B.N.; Kalinnikov, V.A.; Krastev, V.R.; Maksimov, A.N.; Nikityuk, N.M.

    1985-01-01

    This paper describes a high-speed parallel counter that contains 31 inputs and 15 outputs and is implemented by integrated circuits of series 500. The counter is designed for fast sampling of events according to the number of particles that pass simultaneously through the hodoscopic plane of the detector. The minimum delay of the output signals relative to the input is 43 nsec. The duration of the output signals can be varied from 75 to 120 nsec

  5. An anthropologist in parallel structure

    Directory of Open Access Journals (Sweden)

    Noelle Molé Liston

    2016-08-01

    Full Text Available The essay examines the parallels between Molé Liston’s studies on labor and precarity in Italy and the United States’ anthropology job market. Probing the way economic shift reshaped the field of anthropology of Europe in the late 2000s, the piece explores how the neoliberalization of the American academy increased the value in studying the hardships and daily lives of non-western populations in Europe.

  6. Combinatorics of spreads and parallelisms

    CERN Document Server

    Johnson, Norman

    2010-01-01

    Partitions of Vector Spaces Quasi-Subgeometry Partitions Finite Focal-SpreadsGeneralizing André SpreadsThe Going Up Construction for Focal-SpreadsSubgeometry Partitions Subgeometry and Quasi-Subgeometry Partitions Subgeometries from Focal-SpreadsExtended André SubgeometriesKantor's Flag-Transitive DesignsMaximal Additive Partial SpreadsSubplane Covered Nets and Baer Groups Partial Desarguesian t-Parallelisms Direct Products of Affine PlanesJha-Johnson SL(2,

  7. New algorithms for parallel MRI

    International Nuclear Information System (INIS)

    Anzengruber, S; Ramlau, R; Bauer, F; Leitao, A

    2008-01-01

    Magnetic Resonance Imaging with parallel data acquisition requires algorithms for reconstructing the patient's image from a small number of measured lines of the Fourier domain (k-space). In contrast to well-known algorithms like SENSE and GRAPPA and its flavors we consider the problem as a non-linear inverse problem. However, in order to avoid cost intensive derivatives we will use Landweber-Kaczmarz iteration and in order to improve the overall results some additional sparsity constraints.

  8. Wakefield calculations on parallel computers

    International Nuclear Information System (INIS)

    Schoessow, P.

    1990-01-01

    The use of parallelism in the solution of wakefield problems is illustrated for two different computer architectures (SIMD and MIMD). Results are given for finite difference codes which have been implemented on a Connection Machine and an Alliant FX/8 and which are used to compute wakefields in dielectric loaded structures. Benchmarks on code performance are presented for both cases. 4 refs., 3 figs., 2 tabs

  9. Geometric corrections due to inhomogeneous field in the magnetospheric double current layer

    International Nuclear Information System (INIS)

    Callebaut, D.K.; Van den Buys, A.M.

    1985-01-01

    The case of oblique incidence and of a slope in the magnetic field for plane parallel models of the magnetospheric double layer is considered. The two models are the Magnetospheric Double Layer (MDL) and the Magnetospheric Double Current Layer (MDCL). The latter is more appropriate but due to some approximations it gives sometimes incorrect results. An improved model uses a triple current layer. (R.P.)

  10. Aspects of computation on asynchronous parallel processors

    International Nuclear Information System (INIS)

    Wright, M.

    1989-01-01

    The increasing availability of asynchronous parallel processors has provided opportunities for original and useful work in scientific computing. However, the field of parallel computing is still in a highly volatile state, and researchers display a wide range of opinion about many fundamental questions such as models of parallelism, approaches for detecting and analyzing parallelism of algorithms, and tools that allow software developers and users to make effective use of diverse forms of complex hardware. This volume collects the work of researchers specializing in different aspects of parallel computing, who met to discuss the framework and the mechanics of numerical computing. The far-reaching impact of high-performance asynchronous systems is reflected in the wide variety of topics, which include scientific applications (e.g. linear algebra, lattice gauge simulation, ordinary and partial differential equations), models of parallelism, parallel language features, task scheduling, automatic parallelization techniques, tools for algorithm development in parallel environments, and system design issues

  11. Parallel processing of genomics data

    Science.gov (United States)

    Agapito, Giuseppe; Guzzi, Pietro Hiram; Cannataro, Mario

    2016-10-01

    The availability of high-throughput experimental platforms for the analysis of biological samples, such as mass spectrometry, microarrays and Next Generation Sequencing, have made possible to analyze a whole genome in a single experiment. Such platforms produce an enormous volume of data per single experiment, thus the analysis of this enormous flow of data poses several challenges in term of data storage, preprocessing, and analysis. To face those issues, efficient, possibly parallel, bioinformatics software needs to be used to preprocess and analyze data, for instance to highlight genetic variation associated with complex diseases. In this paper we present a parallel algorithm for the parallel preprocessing and statistical analysis of genomics data, able to face high dimension of data and resulting in good response time. The proposed system is able to find statistically significant biological markers able to discriminate classes of patients that respond to drugs in different ways. Experiments performed on real and synthetic genomic datasets show good speed-up and scalability.

  12. Equilibrium double layers in extended Pierce diodes

    International Nuclear Information System (INIS)

    Ciubotariu-Jassy, C.I.

    1992-01-01

    The extended Pierce diode is similar to the standard (or classical) Pierce diode, but has passive circuit elements in place of the short circuit between the electrodes. This device is important as an approximation to real bounded plasma systems. It consists of two parallel plane electrodes (an emitter located at x=0 and a collector located at x=l) and a collisionless cold electron beam travelling between them. The electrons are neutralized by a background of comoving massive ions. This situation is analysed in this paper and new equilibrium double layer (DL) plasma structures are obtained. (author) 6 refs., 3 figs

  13. Congenital maxillary double lip

    Directory of Open Access Journals (Sweden)

    Dinesh Singh Chauhan

    2012-01-01

    Full Text Available Double lip, also referred to as "macrocheilia," is a rare anomaly which affects the upper lip more commonly than the lower lip. It consists of a fold of excess or redundant hypertrophic tissue on the mucosal side of the lip. The congenital double lip is believed to be present at birth and becomes more prominent after eruption of teeth. It affects esthetics and also interferes with speech and mastication. Simple surgical excision produces good functional and cosmetic results. We report a case of a non-syndromic congenital maxillary double lip in a 21-year-old male patient.

  14. Overview of the Force Scientific Parallel Language

    Directory of Open Access Journals (Sweden)

    Gita Alaghband

    1994-01-01

    Full Text Available The Force parallel programming language designed for large-scale shared-memory multiprocessors is presented. The language provides a number of parallel constructs as extensions to the ordinary Fortran language and is implemented as a two-level macro preprocessor to support portability across shared memory multiprocessors. The global parallelism model on which the Force is based provides a powerful parallel language. The parallel constructs, generic synchronization, and freedom from process management supported by the Force has resulted in structured parallel programs that are ported to the many multiprocessors on which the Force is implemented. Two new parallel constructs for looping and functional decomposition are discussed. Several programming examples to illustrate some parallel programming approaches using the Force are also presented.

  15. Automatic Loop Parallelization via Compiler Guided Refactoring

    DEFF Research Database (Denmark)

    Larsen, Per; Ladelsky, Razya; Lidman, Jacob

    For many parallel applications, performance relies not on instruction-level parallelism, but on loop-level parallelism. Unfortunately, many modern applications are written in ways that obstruct automatic loop parallelization. Since we cannot identify sufficient parallelization opportunities...... for these codes in a static, off-line compiler, we developed an interactive compilation feedback system that guides the programmer in iteratively modifying application source, thereby improving the compiler’s ability to generate loop-parallel code. We use this compilation system to modify two sequential...... benchmarks, finding that the code parallelized in this way runs up to 8.3 times faster on an octo-core Intel Xeon 5570 system and up to 12.5 times faster on a quad-core IBM POWER6 system. Benchmark performance varies significantly between the systems. This suggests that semi-automatic parallelization should...

  16. Parallel kinematics type, kinematics, and optimal design

    CERN Document Server

    Liu, Xin-Jun

    2014-01-01

    Parallel Kinematics- Type, Kinematics, and Optimal Design presents the results of 15 year's research on parallel mechanisms and parallel kinematics machines. This book covers the systematic classification of parallel mechanisms (PMs) as well as providing a large number of mechanical architectures of PMs available for use in practical applications. It focuses on the kinematic design of parallel robots. One successful application of parallel mechanisms in the field of machine tools, which is also called parallel kinematics machines, has been the emerging trend in advanced machine tools. The book describes not only the main aspects and important topics in parallel kinematics, but also references novel concepts and approaches, i.e. type synthesis based on evolution, performance evaluation and optimization based on screw theory, singularity model taking into account motion and force transmissibility, and others.   This book is intended for researchers, scientists, engineers and postgraduates or above with interes...

  17. Applied Parallel Computing Industrial Computation and Optimization

    DEFF Research Database (Denmark)

    Madsen, Kaj; NA NA NA Olesen, Dorte

    Proceedings and the Third International Workshop on Applied Parallel Computing in Industrial Problems and Optimization (PARA96)......Proceedings and the Third International Workshop on Applied Parallel Computing in Industrial Problems and Optimization (PARA96)...

  18. Parallel algorithms and cluster computing

    CERN Document Server

    Hoffmann, Karl Heinz

    2007-01-01

    This book presents major advances in high performance computing as well as major advances due to high performance computing. It contains a collection of papers in which results achieved in the collaboration of scientists from computer science, mathematics, physics, and mechanical engineering are presented. From the science problems to the mathematical algorithms and on to the effective implementation of these algorithms on massively parallel and cluster computers we present state-of-the-art methods and technology as well as exemplary results in these fields. This book shows that problems which seem superficially distinct become intimately connected on a computational level.

  19. Parallel computation of rotating flows

    DEFF Research Database (Denmark)

    Lundin, Lars Kristian; Barker, Vincent A.; Sørensen, Jens Nørkær

    1999-01-01

    This paper deals with the simulation of 3‐D rotating flows based on the velocity‐vorticity formulation of the Navier‐Stokes equations in cylindrical coordinates. The governing equations are discretized by a finite difference method. The solution is advanced to a new time level by a two‐step process...... is that of solving a singular, large, sparse, over‐determined linear system of equations, and the iterative method CGLS is applied for this purpose. We discuss some of the mathematical and numerical aspects of this procedure and report on the performance of our software on a wide range of parallel computers. Darbe...

  20. Kinematics and design of a class of parallel manipulators

    Science.gov (United States)

    Hertz, Roger Barry

    1998-12-01

    This dissertation is concerned with the kinematic analysis and design of a class of three degree-of-freedom, spatial parallel manipulators. The class of manipulators is characterized by two platforms, between which are three legs, each possessing a succession of revolute, spherical, and revolute joints. The class is termed the "revolute-spherical-revolute" class of parallel manipulators. Two members of this class are examined. The first mechanism is a double-octahedral variable-geometry truss, and the second is termed a double tripod. The history the mechanisms is explored---the variable-geometry truss dates back to 1984, while predecessors of the double tripod mechanism date back to 1869. This work centers on the displacement analysis of these three-degree-of-freedom mechanisms. Two types of problem are solved: the forward displacement analysis (forward kinematics) and the inverse displacement analysis (inverse kinematics). The kinematic model of the class of mechanism is general in nature. A classification scheme for the revolute-spherical-revolute class of mechanism is introduced, which uses dominant geometric features to group designs into 8 different sub-classes. The forward kinematics problem is discussed: given a set of independently controllable input variables, solve for the relative position and orientation between the two platforms. For the variable-geometry truss, the controllable input variables are assumed to be the linear (prismatic) joints. For the double tripod, the controllable input variables are the three revolute joints adjacent to the base (proximal) platform. Multiple solutions are presented to the forward kinematics problem, indicating that there are many different positions (assemblies) that the manipulator can assume with equivalent inputs. For the double tripod these solutions can be expressed as a 16th degree polynomial in one unknown, while for the variable-geometry truss there exist two 16th degree polynomials, giving rise to 256