Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

Science.gov (United States)

Guo, Yanxia; Walsh, Alice M; Canavan, Mary; Wechalekar, Mihir D; Cole, Suzanne; Yin, Xuefeng; Scott, Brittney; Loza, Mathew; Orr, Carl; McGarry, Trudy; Bombardieri, Michele; Humby, Frances; Proudman, Susanna M; Pitzalis, Costantino; Smith, Malcolm D; Friedman, Joshua R; Anderson, Ian; Madakamutil, Loui; Veale, Douglas J; Fearon, Ursula; Nagpal, Sunil

2018-01-01

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralgia and inflammatory arthritis (IA) in some patients. Herein, using Nivolumab (anti-PD-1 antagonist)-responsive genes along with transcriptomics of synovial tissue from multiple stages of rheumatoid arthritis (RA) disease progression, we have interrogated the activity status of PD-1 pathway during RA development. We demonstrate that the expression of PD-1 was increased in early and established RA synovial tissue compared to normal and OA synovium, whereas that of its ligands, programmed death ligand-1 (PD-L1) and PD-L2, was increased at all the stages of RA disease progression, namely arthralgia, IA/undifferentiated arthritis, early RA and established RA. Further, we show that RA patients expressed PD-1 on a majority of synovial tissue infiltrating CD4+ and CD8+ T cells. Moreover, enrichment of Nivolumab gene signature was observed in IA and RA, indicating that the PD-1 pathway was downregulated during RA disease progression. Furthermore, serum soluble (s) PD-1 levels were increased in autoantibody positive early RA patients. Interestingly, most of the early RA synovium tissue sections showed negative PD-L1 staining by immunohistochemistry. Therefore, downregulation in PD-1 inhibitory signaling in RA could be attributed to increased serum sPD-1 and decreased synovial tissue PD-L1 levels. Taken together, these data suggest that agonistic PD1 antibody-based therapeutics may show efficacy in RA treatment and interception.

Effect of pancreas disease (PD) on quality attributes of raw and smoked fillets of Atlantic salmon (Salmo salar L.)

DEFF Research Database (Denmark)

Lerfall, Jørgen; Larsson, Thomas; Birkeland, Sveinung

2012-01-01

The impact of pancreas disease (PD) on fillet quality of raw and cold-smoked Atlantic salmon was investigated. Commercially reared fish were sorted into six groups: (1) Control (healthy fish), (2) SAV (infection with salmonid alphavirus, without PD outbreak), (3) PD0 (PD diagnosis at slaughter), (4...

Emergency department surge: models and practical implications.

Science.gov (United States)

Nager, Alan L; Khanna, Kajal

2009-08-01

Emergency Department crowding has long been described. Despite the daily challenges of managing emergency department volume and acuity; a surge response during a disaster entails even greater challenges including collaboration, intervention, and resourcefulness to effectively carry out pediatric disaster management. Understanding surge and how to respond with appropriate planning will lead to success. To achieve this, we sought to analyze models of surge; review regional and national data outlining surge challenges and factors that impact surge; and to outline potential solutions. We conducted a systemic review and included articles and documents that best described the theoretical and practical basis of surge response. We organized the systematic review according to the following questions: What are the elements and models that are delineated by the concept of surge? What is the basis for surge response based on regional and national published sources? What are the broad global solutions? What are the major lessons observed that will impact effective surge capacity? Multiple models of surge are described including public health, facility-based and community-based; a 6-tiered response system; and intrinsic or extrinsic surge capacity. In addition, essential components (4 S's of surge response) are described along with regional and national data outlining surge challenges, impacting factors, global solutions, and lesions observed. There are numerous shortcomings regionally and nationally affecting our ability to provide an effective and coordinated surge response. Planning, education, and training will lead to an effective pediatric disaster management response.

Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial.

Science.gov (United States)

Postuma, Ronald B; Anang, Julius; Pelletier, Amelie; Joseph, Lawrence; Moscovich, Mariana; Grimes, David; Furtado, Sarah; Munhoz, Renato P; Appel-Cresswell, Silke; Moro, Adriana; Borys, Andrew; Hobson, Douglas; Lang, Anthony E

2017-10-24

To assess effects of caffeine on Parkinson disease (PD). In this multicenter parallel-group controlled trial, patients with PD with 1-8 years disease duration, Hoehn & Yahr stages I-III, on stable symptomatic therapy were randomized to caffeine 200 mg BID vs matching placebo capsules for 6-18 months. The primary research question was whether objective motor scores would differ at 6 months (Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale [MDS-UPDRS]-III, Class I evidence). Secondary outcomes included safety and tolerability, motor symptoms (MDS-UPDRS-II), motor fluctuations, sleep, nonmotor symptoms (MDS-UPDRS-I), cognition (Montreal Cognitive Assessment), and quality of life. Sixty patients received caffeine and 61 placebo. Caffeine was well-tolerated with similar prevalence of side effects as placebo. There was no improvement in motor parkinsonism (the primary outcome) with caffeine treatment compared to placebo (difference between groups -0.48 [95% confidence interval -3.21 to 2.25] points on MDS-UPDRS-III). Similarly, on secondary outcomes, there was no change in motor signs or motor symptoms (MDS-UPDRS-II) at any time point, and no difference on quality of life. There was a slight improvement in somnolence over the first 6 months, which attenuated over time. There was a slight increase in dyskinesia with caffeine (MDS-UPDRS-4.1+4.2 = 0.25 points higher), and caffeine was associated with worse cognitive testing scores (average Montreal Cognitive Assessment = 0.66 [0.01, 1.32] worse than placebo). Caffeine did not provide clinically important improvement of motor manifestations of PD (Class I evidence). Epidemiologic links between caffeine and lower PD risk do not appear to be explained by symptomatic effects. NCT01738178. This study provides Class I evidence that for patients with PD, caffeine does not significantly improve motor manifestations. © 2017 American Academy of Neurology.

Electrodynamics properties of auroral surges

International Nuclear Information System (INIS)

Robinson, R.M.; Vondrak, R.R.

1990-01-01

The incoherent scatter radar technique provides an excellent means to study the ionization and electric fields associated with auroral precipitation events. One of the most intense and dynamic auroral events is the so-called surge or breakup aurora that accompanies auroral substorms. For their purposes they define a surge as a transient intensification of auroral precipitation that occurs simultaneously with a pronounced negative bay in the ground magnetometer data. They present data obtained during five such events in 1980 and 1981. Prior to the surge, auroral forms move equatorward, develop ray structure, and intensify. The surge is identified by an apparent poleward motion of the aurora producing aurorally associated ionization that extends over several hundred kilometers in latitude. The presurge auroral forms are embedded in a region of northward electric field. The auroral forms that comprise the surge span a region within which the meridional electric field is small and at times southward. A westward electric field is often but not always present within the surge. The behavior of the westward electric field is significantly different from the north-south field, in that sharp spatial gradients are absent even in very disturbed conditions. Although the westward Hall currents are mostly responsible for the negative bays that accompany the surge, at times the westward Pedersen current sustained by the westward electric field can be important. Sudden variations in the H component of the ground magnetogram can be caused by motions of the aurora or by temporal variations in the fields or conductivities. They present a model that simulates the observed changes in electric field and precipitation that accompany surges. The perturbation in the electric field produced by the surge is simulated by adding negative potential in regions of intense precipitation

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study.

Science.gov (United States)

Firbank, M J; Yarnall, A J; Lawson, R A; Duncan, G W; Khoo, T K; Petrides, G S; O'Brien, J T; Barker, R A; Maxwell, R J; Brooks, D J; Burn, D J

2017-04-01

To assess reductions of cerebral glucose metabolism in Parkinson's disease (PD) with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET), and their associations with cognitive decline. FDG-PET was performed on a cohort of 79 patients with newly diagnosed PD (mean disease duration 8 months) and 20 unrelated controls. PD participants were scanned while on their usual dopaminergic medication. Cognitive testing was performed at baseline, and after 18 months using the Cognitive Drug Research (CDR) and Cambridge Neuropsychological Test Automated Battery (CANTAB) computerised batteries, the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA). We used statistical parametric mapping (SPM V.12) software to compare groups and investigate voxelwise correlations between FDG metabolism and cognitive score at baseline. Linear regression was used to evaluate how levels of cortical FDG metabolism were predictive of subsequent cognitive decline rated with the MMSE and MoCA. PD participants showed reduced glucose metabolism in the occipital and inferior parietal lobes relative to controls. Low performance on memory-based tasks was associated with reduced FDG metabolism in posterior parietal and temporal regions, while attentional performance was associated with more frontal deficits. Baseline parietal to cerebellum FDG metabolism ratios predicted MMSE (β=0.38, p=0.001) and MoCA (β=0.3, p=0.002) at 18 months controlling for baseline score. Reductions in cortical FDG metabolism were present in newly diagnosed PD, and correlated with performance on neuropsychological tests. A reduced baseline parietal metabolism is associated with risk of cognitive decline and may represent a potential biomarker for this state and the development of PD dementia. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease.

Science.gov (United States)

Noyce, Alastair J; R'Bibo, Lea; Peress, Luisa; Bestwick, Jonathan P; Adams-Carr, Kerala L; Mencacci, Niccolo E; Hawkes, Christopher H; Masters, Joseph M; Wood, Nicholas; Hardy, John; Giovannoni, Gavin; Lees, Andrew J; Schrag, Anette

2017-02-01

A number of early features can precede the diagnosis of Parkinson's disease (PD). To test an online, evidence-based algorithm to identify risk indicators of PD in the UK population. Participants aged 60 to 80 years without PD completed an online survey and keyboard-tapping task annually over 3 years, and underwent smell tests and genotyping for glucocerebrosidase (GBA) and leucine-rich repeat kinase 2 (LRRK2) mutations. Risk scores were calculated based on the results of a systematic review of risk factors and early features of PD, and individuals were grouped into higher (above 15th centile), medium, and lower risk groups (below 85th centile). Previously defined indicators of increased risk of PD ("intermediate markers"), including smell loss, rapid eye movement-sleep behavior disorder, and finger-tapping speed, and incident PD were used as outcomes. The correlation of risk scores with intermediate markers and movement of individuals between risk groups was assessed each year and prospectively. Exploratory Cox regression analyses with incident PD as the dependent variable were performed. A total of 1323 participants were recruited at baseline and >79% completed assessments each year. Annual risk scores were correlated with intermediate markers of PD each year and baseline scores were correlated with intermediate markers during follow-up (all P values < 0.001). Incident PD diagnoses during follow-up were significantly associated with baseline risk score (hazard ratio = 4.39, P = .045). GBA variants or G2019S LRRK2 mutations were found in 47 participants, and the predictive power for incident PD was improved by the addition of genetic variants to risk scores. The online PREDICT-PD algorithm is a unique and simple method to identify indicators of PD risk. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder

Community health facility preparedness for a cholera surge in Haiti.

Science.gov (United States)

Mobula, Linda Meta; Jacquet, Gabrielle A; Weinhauer, Kristin; Alcidas, Gladys; Thomas, Hans-Muller; Burnham, Gilbert

2013-01-01

With increasing population displacement and worsening water insecurity after the 2010 earthquake, Haiti experienced a large cholera outbreak. Our goal was to evaluate the strengths and weaknesses of seven community health facilities' ability to respond to a surge in cholera cases. Since 2010, Catholic Relief Services (CRS) with a number of public and private donors has been working with seven health facilities in an effort to reduce morbidity and mortality from cholera infection. In November 2012, CRS through the Centers for Disease Control and Prevention (CDC)'s support, asked the Johns Hopkins Center for Refugee and Disaster Response to conduct a cholera surge simulation tabletop exercise at these health facilities to improve each facility's response in the event of a cholera surge. Using simulation development guidelines from the Pan American Health Organization and others, a simulation scenario script was produced that included situations of differing severity, supply chain, as well as a surge of patients. A total of 119 hospital staff from seven sites participated in the simulation exercise including community health workers, clinicians, managers, pharmacists, cleaners, and security guards. Clinics that had challenges during the simulated clinical care of patients were those that did not appropriately treat all cholera patients according to protocol, particularly those that were vulnerable, those that would need additional staff to properly treat patients during a surge of cholera, and those that required a better inventory of supplies. Simulation-based activities have the potential to identify healthcare delivery system vulnerabilities that are amenable to intervention prior to a cholera surge.

Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade.

Science.gov (United States)

Lipson, Evan J; Lilo, Mohammed T; Ogurtsova, Aleksandra; Esandrio, Jessica; Xu, Haiying; Brothers, Patricia; Schollenberger, Megan; Sharfman, William H; Taube, Janis M

2017-01-01

Monoclonal antibodies that block immune regulatory proteins such as programmed death-1 (PD-1) have demonstrated remarkable efficacy in controlling the growth of multiple tumor types. Unresectable or metastatic basal cell carcinoma, however, has largely gone untested. Because PD-Ligand-1 (PD-L1) expression in other tumor types has been associated with response to anti-PD-1, we investigated the expression of PD-L1 and its association with PD-1 expression in the basal cell carcinoma tumor microenvironment. Among 40 basal cell carcinoma specimens, 9/40 (22%) demonstrated PD-L1 expression on tumor cells, and 33/40 (82%) demonstrated PD-L1 expression on tumor-infiltrating lymphocytes and associated macrophages. PD-L1 was observed in close geographic association to PD-1+ tumor infiltrating lymphocytes. Additionally, we present, here, the first report of an objective anti-tumor response to pembrolizumab (anti-PD-1) in a patient with metastatic PD-L1 (+) basal cell carcinoma, whose disease had previously progressed through hedgehog pathway-directed therapy. The patient remains in a partial response 14 months after initiation of therapy. Taken together, our findings provide a rationale for testing anti-PD-1 therapy in patients with advanced basal cell carcinoma, either as initial treatment or after acquired resistance to hedgehog pathway inhibition.

Study of storm surge trends in typhoon-prone coastal areas based on observations and surge-wave coupled simulations

Science.gov (United States)

Feng, Xingru; Li, Mingjie; Yin, Baoshu; Yang, Dezhou; Yang, Hongwei

2018-06-01

This is a study of the storm surge trends in some of the typhoon-prone coastal areas of China. An unstructured-grid, storm surge-wave-tide coupled model was established for the coastal areas of Zhejiang, Fujian and Guangdong provinces. The coupled model has a high resolution in coastal areas, and the simulated results compared well with the in situ observations and satellite altimeter data. The typhoon-induced storm surges along the coast of the study areas were simulated based on the established coupled model for the past 20 years (1997-2016). The simulated results were used to analyze the trends of the storm surges in the study area. The extreme storm surge trends along the central coast of Fujian Province reached up to 0.06 m/y, significant at the 90% confidence level. The duration of the storm surges greater than 1.0 and 0.7 m had an increasing trend along the coastal area of northern Fujian Province, significant at confidence levels of 70%-91%. The simulated trends of the extreme storm surges were also validated by observations from two tide gauge stations. Further studies show that the correlation coefficient (RTE) between the duration of the storm surge greater than 1 m and the annual ENSO index can reach as high as 0.62, significant at the 99% confidence level. This occurred in a location where the storm surge trend was not significant. For the areas with significant increasing storm surge trends, RTE was small and not significant. This study identified the storm surge trends for the full complex coastline of the study area. These results are useful both for coastal management by the government and for coastal engineering design.

[Neonatal screening of hemoglobinopathies and G6PD deficiency in Catalonia (Spain). Molecular study of sickle cell disease associated with alpha thalassemia and G6PD deficiency].

Science.gov (United States)

Mañú Pereira, María Del Mar; Cabot, Anna; Martínez González, Ana; Sitjà Navarro, Eulalia; Cararach, Vicent; Sabrià, Josep; Boixaderas, Jordi; Teixidor, Roser; Bosch, Albert; López Vílchez, M Angeles; Martín Ibáñez, Itziar; Carrión, Teresa; Plaja, Pere; Sánchez, Mario; Vives Corrons, José Luis

2007-06-30

The prevalence of hemoglobinopathies and glucose-6-phosphate dehidrogenase (G6PD) deficiency in the Catalan neonatal population is increasing due to immigration. Coinheritance of more than a single RBC genetic defect is becoming more frequent and diagnostic pitfalls are also increasing. We intended to demonstrate the need to perform an early diagnosis of sickle cell disease (SCD) by means of neonatal screening, to establish the prevalence of SCD associated with alpha thalassemia and G6PD deficiency and to identify genotypes associated with sickle cell disease and G6PD deficiency. 4,020 blood samples from newborns were screened. For the screening of hemoglobinopathies the high performance liquid chromatography method was used and for G6PD deficiency the fluorescent spot test was employed. We studied the association between betaS gene and alpha thalassaemia del-3.7 Kb. SCD and G6PD deficiency genotypes were established. Prevalence of SCD in population at risk was 1/475 newborns. Prevalence of G6PD deficiency in population at risk was 1/43, and in autochthonous population was 1/527 newborns. In all the cases, sickle hemoglobin was confirmed by ARMS (amplification refractory mutation system). Association between betaS gene and alpha thalassaemia del-3.7 Kb was found in 32.2% of the samples, and an association between betaS gene and G6PD deficiency was observed in 7% of the samples. This study confirms the high prevalence of SCD and G6PD deficiency in population at risk as well as their genetic and clinical heterogeneity. The study of genotype/phenotype relationships allows a better knowledge of molecular mechanism and is useful to establish suitable criteria of diagnosis.

Tide-surge interaction in the English Channel

Directory of Open Access Journals (Sweden)

D. Idier

2012-12-01

Full Text Available The English Channel is characterised by strong tidal currents and a wide tidal range, such that their influence on surges is expected to be non-negligible. In order to better assess storm surges in this zone, tide-surge interactions are investigated. A preliminary data analysis on hourly surges indicates some preferential times of occurrence of large storm surges at rising tide, especially in Dunkerque. To examine this further, a numerical modelling approach is chosen, based on the 2DH shallow-water model (MARS. The surges are computed both with and without tide interaction. For the two selected events (the November 2007 North Sea and March 2008 Atlantic storms, it appears that the instantaneous tide-surge interaction is seen to be non-negligible in the eastern half of the English Channel, reaching values of 74 cm (i.e. 50% of the same event maximal storm surge in the Dover Strait for the studied cases. This interaction decreases in westerly direction. In the risk-analysis community in France, extreme water levels have been determined assuming skew surges and tide as independent. The same hydrodynamic model is used to investigate this dependence in the English Channel. Simple computations are performed with the same meteorological forcing, while varying the tidal amplitude, and the skew surge differences D_SS are analysed. Skew surges appear to be tide-dependent, with negligible values of D_SS (<0.05 m over a large portion of the English Channel, although reaching several tens of centimetres in some locations (e.g. the Isle of Wight and Dover Strait.

Tropical cyclone induced asymmetry of sea level surge and fall and its presentation in a storm surge model with parametric wind fields

Science.gov (United States)

Peng, Machuan; Xie, Lian; Pietrafesa, Leonard J.

The asymmetry of tropical cyclone induced maximum coastal sea level rise (positive surge) and fall (negative surge) is studied using a three-dimensional storm surge model. It is found that the negative surge induced by offshore winds is more sensitive to wind speed and direction changes than the positive surge by onshore winds. As a result, negative surge is inherently more difficult to forecast than positive surge since there is uncertainty in tropical storm wind forecasts. The asymmetry of negative and positive surge under parametric wind forcing is more apparent in shallow water regions. For tropical cyclones with fixed central pressure, the surge asymmetry increases with decreasing storm translation speed. For those with the same translation speed, a weaker tropical cyclone is expected to gain a higher AI (asymmetry index) value though its induced maximum surge and fall are smaller. With fixed RMW (radius of maximum wind), the relationship between central pressure and AI is heterogeneous and depends on the value of RMW. Tropical cyclone's wind inflow angle can also affect surge asymmetry. A set of idealized cases as well as two historic tropical cyclones are used to illustrate the surge asymmetry.

The Role of Programmed Cell Death Ligand-1 (PD-L1/CD274) in the Development of Graft versus Host Disease

Science.gov (United States)

Al-Chaqmaqchi, Heevy; Sadeghi, Behnam; Abedi-Valugerdi, Manuchehr; Al-Hashmi, Sulaiman; Fares, Mona; Kuiper, Raoul; Lundahl, Joachim

2013-01-01

Programmed cell death ligand-1 (PD-L1/CD274) is an immunomodulatory molecule involved in cancer and complications of bone marrow transplantation, such as graft rejection and graft-versus-host disease. The present study was designed to assess the dynamic expression of this molecule after hematopoietic stem cell transplantation in relation to acute graft-versus-host disease. Female BALB/c mice were conditioned with busulfan and cyclophosphamide and transplanted with either syngeneic or allogeneic (male C57BL/6 mice) bone marrow and splenic cells. The expression of PD-L1 was evaluated at different time points employing qPCR, western blot and immunohistochemistry. Allogeneic- but not syngeneic-transplanted animals exhibited a marked up-regulation of PD-L1 expression in the muscle and kidney, but not the liver, at days 5 and 7 post transplantation. In mice transplanted with allogeneic bone marrow cells, the enhanced expression of PD-L1 was associated with high serum levels of IFNγ and TNFα at corresponding intervals. Our findings demonstrate that PD-L1 is differently induced and expressed after allogeneic transplantation than it is after syngeneic transplantation, and that it is in favor of target rather than non-target organs at the early stages of acute graft-versus-host disease. This is the first study to correlate the dynamics of PD-L1 at the gene-, protein- and activity levels with the early development of acute graft-versus-host disease. Our results suggest that the higher expression of PD-L1 in the muscle and kidney (non-target tissues) plays a protective role in skeletal muscle during acute graft-versus-host disease. PMID:23593203

Effect of PD-WEBB training on balance impairment and falls in people with Parkinson’s disease%PD-WEBB训练对帕金森病平衡障碍和跌倒的影响

Institute of Scientific and Technical Information of China (English)

谷绍娟; 宋治; 范学军; 陈茹; 郑文; 严文广

2013-01-01

Objective:To determine the effect of Parkinson’s disease-weight bearing exercise for better balance (PD-WEBB) exercise on balance impairment and falls in people with Parkinson's disease (PD).Methods:A single-blind, randomized controlled clinical trial was conducted. The falls efficacy scale score, unified Parkinson disease rating scale (UPDRS) score and Mini-BESTest score were measured and compared between a PD-WEBB group and a control group. Results:hTe falls effcacy scale score, UPDRS-2 score, UPDRS-3 score and Mini-BESTest score were improved in the PD-WEBB group compared with the control group (P Conclusion:PD-WEBB training can significantly improve the balance impairment and quality of life to prevent falls. PD-WEBB training is suitable for PD patients in China, and is a reasonable, effective and sustainable training of family and community assessment model.%目的：评价PD-WEBB训练对帕金森病(Parkinson’s disease，PD)患者平衡障碍和跌倒的影响。方法：采用随机、单盲、对照设计分析PD-WEBB训练8周前后PD-WEBB组与对照组PD患者跌倒功效量表(falls effcacy scale，FES)评分、帕金森病综合评分量表(UPDRS)评分和Mini-Balance Evaluation Systems Test (Mini-BESTest)评分的变化。结果：8周后PD-WEBB组FES评分、UPDRS-2评分、UPDRS-3评分和Mini-BESTest评分较对照组有明显变化(P<0.05)，而两组间UPDRS-1评分变化不明显。结论：PD-WEBB训练可以明显改善PD患者的平衡障碍，提高患者日常生活质量，预防跌倒。PD-WEBB训练适合中国PD患者，是一种合理有效的可持续的家庭训练模式。

Surge of a Complex Glacier System - The Current Surge of the Bering-Bagley Glacier System, Alaska

Science.gov (United States)

Herzfeld, U. C.; McDonald, B.; Trantow, T.; Hale, G.; Stachura, M.; Weltman, A.; Sears, T.

2013-12-01

Understanding fast glacier flow and glacial accelerations is important for understanding changes in the cryosphere and ultimately in sea level. Surge-type glaciers are one of four types of fast-flowing glaciers --- the other three being continuously fast-flowing glaciers, fjord glaciers and ice streams --- and the one that has seen the least amount of research. The Bering-Bagley Glacier System, Alaska, the largest glacier system in North America, surged in 2011 and 2012. Velocities decreased towards the end of 2011, while the surge kinematics continued to expand. A new surge phase started in summer and fall 2012. In this paper, we report results from airborne observations collected in September 2011, June/July and September/October 2012 and in 2013. Airborne observations include simultaneously collected laser altimeter data, videographic data, GPS data and photographic data and are complemented by satellite data analysis. Methods range from classic interpretation of imagery to analysis and classification of laser altimeter data and connectionist (neural-net) geostatistical classification of concurrent airborne imagery. Results focus on the characteristics of surge progression in a large and complex glacier system (as opposed to a small glacier with relatively simple geometry). We evaluate changes in surface elevations including mass transfer and sudden drawdowns, crevasse types, accelerations and changes in the supra-glacial and englacial hydrologic system. Supraglacial water in Bering Glacier during Surge, July 2012 Airborne laser altimeter profile across major rift in central Bering Glacier, Sept 2011

Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort.

Science.gov (United States)

Chou, Kelvin L; Elm, Jordan J; Wielinski, Catherine L; Simon, David K; Aminoff, Michael J; Christine, Chadwick W; Liang, Grace S; Hauser, Robert A; Sudarsky, Lewis; Umeh, Chizoba C; Voss, Tiffini; Juncos, Jorge; Fang, John Y; Boyd, James T; Bodis-Wollner, Ivan; Mari, Zoltan; Morgan, John C; Wills, Anne-Marie; Lee, Stephen L; Parashos, Sotirios A

2017-06-15

Recognizing the factors associated with falling in Parkinson's disease (PD) would improve identification of at-risk individuals. To examine frequency of falling and baseline characteristics associated with falling in PD using the National Institute of Neurological Disorders and Stroke (NINDS) Exploratory Trials in PD Long-term Study-1 (NET-PD LS-1) dataset. The LS-1 database included 1741 early treated PD subjects (median 4year follow-up). Baseline characteristics were tested for a univariate association with post-baseline falling during the trial. Significant variables were included in a multivariable logistic regression model. A separate analysis using a negative binomial model investigated baseline factors on fall rate. 728 subjects (42%) fell during the trial, including at baseline. A baseline history of falls was the factor most associated with post-baseline falling. Men had lower odds of post-baseline falling compared to women, but for men, the probability of a post-baseline fall increased with age such that after age 70, men and women had similar odds of falling. Other baseline factors associated with a post-baseline fall and increased fall rate included the Unified PD Rating Scale (UPDRS) Activities of Daily Living (ADL) score, total functional capacity (TFC), baseline ambulatory capacity score and dopamine agonist monotherapy. Falls are common in early treated PD. The biggest risk factor for falls in PD remains a history of falling. Measures of functional ability (UPDRS ADL, TFC) and ambulatory capacity are novel clinical risk factors needing further study. A significant age by sex interaction may help to explain why age has been an inconsistent risk factor for falls in PD. Copyright © 2017 Elsevier B.V. All rights reserved.

48 CFR 252.217-7001 - Surge option.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Surge option. 252.217-7001... Clauses 252.217-7001 Surge option. As prescribed in 217.208-70(b), use the following clause: Surge Option (AUG 1992) (a) General. The Government has the option to— (1) Increase the quantity of supplies or...

Storm Surge and Tide Interaction: A Complete Paradigm

Science.gov (United States)

Horsburgh, K.

2014-12-01

Estimates show that in 2005, in the largest 136 coastal cities, there were 40 million people and 3,000 billion of assets exposed to 1 in 100 year coastal flood events. Mean sea level rise will increase this exposure to 150 million people and 35,000 billion of assets by 2070. Any further change in the statistics of flood frequency or severity would impact severely on economic and social systems. It is therefore crucial to understand the physical drivers of extreme storm surges, and to have confidence in datasets used for extreme sea level statistics. Much previous research has focussed on the process of tide-surge interaction, and it is now widely accepted that the physical basis of tide-surge interaction is that a phase shift of the tidal signal represents the effect of the surge on the tide. The second aspect of interaction is that shallow water momentum considerations imply that differing tidal states should modulate surge generation: wind stress should have greater surge-generating potential on lower tides. We present results from a storm surge model of the European shelf that demonstrate that tidal range does have an effect on the surges generated. The cycle-integrated effects of wind stress (i.e. the skew surge) are greater when tidal range is low. Our results contradict the absence of any such correlation in tide gauge records. This suggests that whilst the modulating effect of the tide on the skew surge (the time-independent difference between peak prediction and observations) is significant, the difference between individual storms is dominant. This implies that forecasting systems must predict salient detail of the most intense storms. A further implication is that flood forecasting models need to simulate tides with acceptable accuracy at all coastal locations. We extend our model analysis to show that the same modulation of storm surges (by tidal conditions) applies to tropical cyclones. We conduct simulations using a mature operational storm surge model

Storm surge climatology report

OpenAIRE

Horsburgh, Kevin; Williams, Joanne; Cussack, Caroline

2017-01-01

Any increase in flood frequency or severity due to sea level rise or changes in storminess would adversely impact society. It is crucial to understand the physical drivers of extreme storm surges to have confidence in the datasets used for extreme sea level statistics. We will refine and improve methods to the estimation of extreme sea levels around Europe and more widely. We will do so by developing a comprehensive world picture of storm surge distribution (including extremes) for both tropi...

Effect of piping systems on surge in centrifugal compressors

International Nuclear Information System (INIS)

Tamaki, Hideaki

2008-01-01

There is a possibility that the exchange of the piping system may change the surge characteristic of a compressor. The piping system of a plant is not always the same as that of a test site. Then it is important to evaluate the effect of piping systems on surge characteristics in centrifugal compressors. Several turbochargers combined with different piping systems were tested. The lumped parameter model which was simplified to be solved easily was applied for the prediction of surge point. Surge lines were calculated with the linearlized lumped parameter model. The difference between the test and calculated results was within 10 %. Trajectory of surge cycle was also examined by solving the lumped parameter model. Mild surge and deep surge were successfully predicted. This study confirmed that the lumped parameter model was a very useful tool to predict the effect of piping systems on surge characteristics in centrifugal compressors, even though that was a simple model

Stochastic modelling of direct costs of pancreas disease (PD) in Norwegian farmed Atlantic salmon (Salmo salar L.).

Science.gov (United States)

Aunsmo, Arnfinn; Valle, Paul Steinar; Sandberg, Marianne; Midtlyng, Paul Johan; Bruheim, Torkjel

2010-02-01

An economic model for estimating the direct costs of disease in industrial aquaculture was developed to include the following areas: biological losses, extraordinary costs, costs of treatment, costs of prevention and insurance pay-out. Direct costs of a pancreas disease (PD) outbreak in Norwegian farmed Atlantic salmon were estimated in the model, using probability distributions for the biological losses and expenditures associated with the disease. The biological effects of PD on mortality, growth, feed conversion and carcass quality and their correlations, together with costs of prevention were established using elicited data from an expert panel, and combined with basal losses in a control model. Extraordinary costs and costs associated with treatment were collected through a questionnaire sent to staff managing disease outbreaks. Norwegian national statistics for 2007 were used for prices and production costs in the model. Direct costs associated with a PD-outbreak in a site stocked with 500,000 smolts (vs. a similar site without the disease) were estimated to NOK (Norwegian kroner) 14.4 million (5% and 95% percentile: 10.5 and 17.8) (NOK=euro0.12 or $0.17 for 2007). Production was reduced to 70% (5% and 95% percentile: 57% and 81%) saleable biomass, and at an increased production cost of NOK 6.0 per kg (5% and 95% percentile: 3.5 and 8.7). Copyright 2009 Elsevier B.V. All rights reserved.

Validation of a surge model by full scale testing

NARCIS (Netherlands)

Smeulers, J.P.M.; Slot, H.J.; Meulendijks, D.

2011-01-01

Surge of turbo compressors can cause large stepwise changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. Surge is usually avoided by an anti surge controller (ASC). However, in spite of the ASC surge cycles may

Validation of a surge model by full scale testing

NARCIS (Netherlands)

Slot, H.J.; Meulendijks, D.; Smeulers, J.P.M.

2009-01-01

Surge of turbo compressors can cause large stepwise changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. Surge is usually avoided by an anti surge controller (ASC). However, in spite of the ASC surge cycles may

Coastal emergency managers' preferences for storm surge forecast communication.

Science.gov (United States)

Morrow, Betty Hearn; Lazo, Jeffrey K

2014-01-01

Storm surge, the most deadly hazard associated with tropical and extratropical cyclones, is the basis for most evacuation decisions by authorities. One factor believed to be associated with evacuation noncompliance is a lack of understanding of storm surge. To address this problem, federal agencies responsible for cyclone forecasts are seeking more effective ways of communicating storm surge threat. To inform this process, they are engaging various partners in the forecast and warning process.This project focuses on emergency managers. Fifty-three emergency managers (EMs) from the Gulf and lower Atlantic coasts were surveyed to elicit their experience with, sources of, and preferences for storm surge information. The emergency managers-who are well seasoned in hurricane response and generally rate the surge risk in their coastal areas above average or extremely high-listed storm surge as their major concern with respect to hurricanes. They reported a general lack of public awareness about surge. Overall they support new ways to convey the potential danger to the public, including the issuance of separate storm surge watches and warnings, and the expression of surge heights using feet above ground level. These EMs would like more maps, graphics, and visual materials for use in communicating with the public. An important concern is the timing of surge forecasts-whether they receive them early enough to be useful in their evacuation decisions.

The Exosomal/Total α-Synuclein Ratio in Plasma Is Associated With Glucocerebrosidase Activity and Correlates With Measures of Disease Severity in PD Patients

Directory of Open Access Journals (Sweden)

Silvia Cerri

2018-05-01

Full Text Available Intensive research efforts in the field of Parkinson’s disease (PD are focusing on identifying reliable biomarkers which possibly help physicians in predicting disease onset, diagnosis, and progression as well as evaluating the response to disease-modifying treatments. Given that abnormal alpha-synuclein (α-syn accumulation is a primary component of PD pathology, this protein has attracted considerable interest as a potential biomarker for PD. Alpha-synuclein can be detected in several body fluids, including plasma, where it can be found as free form or in association with exosomes, small membranous vesicles secreted by virtually all cell types. Together with α-syn accumulation, lysosomal dysfunctions seem to play a central role in the pathogenesis of PD, given the crucial role of lysosomes in the α-syn degradation. In particular, heterozygous mutations in the GBA1 gene encoding lysosomal enzyme glucocerebrosidase (GCase are currently considered as the most important risk factor for PD. Different studies have found that GCase deficiency leads to accumulation of α-syn; whereas at the same time, increased α-syn may inhibit GCase function, thus inducing a bidirectional pathogenic loop. In this study, we investigated whether changes in plasma total and exosome-associated α-syn could correlate with disease status and clinical parameters in PD and their relationship with GCase activity. We studied 39 PD patients (mean age: 65.2 ± 8.9; men: 25, without GBA1 mutations, and 33 age-matched controls (mean age: 61.9 ± 6.2; men: 15. Our results showed that exosomes from PD patients contain a greater amount of α-syn compared to healthy subjects (25.2 vs. 12.3 pg/mL, p < 0.001 whereas no differences were found in plasma total α-syn levels (15.7 vs. 14.8 ng/mL, p = 0.53. Moreover, we highlighted a significant increase of plasma exosomal α-syn/total α-syn ratio in PD patients (1.69 vs. 0.89, p < 0.001, which negatively correlates with disease

Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: a potential target for anti-PD-1/PD-L1 therapy.

Science.gov (United States)

Roberts, Jordan A; Gonzalez, Raul S; Das, Satya; Berlin, Jordan; Shi, Chanjuan

2017-12-01

Poorly differentiated neuroendocrine carcinoma of the digestive system has a dismal prognosis with limited treatment options. This study aimed to investigate expression of the PD-1/PD-L1 pathway in these tumors. Thirty-seven patients with a poorly differentiated neuroendocrine carcinoma of the digestive system were identified. Their electronic medical records, pathology reports, and pathology slides were reviewed for demographics, clinical history, and pathologic features. Tumor sections were immunohistochemically labeled for PD-1 and PD-L1, and expression of PD-1 and PD-L1 on tumor and tumor-associated immune cells was analyzed and compared between small cell and large cell neuroendocrine carcinomas. The mean age of patients was 61 years old with 18 men and 19 women. The colorectum (n=20) was the most common primary site; other primary sites included the pancreaticobiliary system, esophagus, stomach, duodenum, and ampulla. Expression of PD-1 was detected on tumor cells (n=6, 16%) as well as on tumor-associated immune cells (n=23, 63%). The 6 cases with PD-1 expression on tumor cells also had the expression on immune cells. Expression of PD-L1 was visualized on tumor cells in 5 cases (14%) and on tumor-associated immune cells in 10 cases (27%). There was no difference in PD-1 and PD-L1 expression between small cell and large cell neuroendocrine carcinomas. In conclusion, PD-1/PD-L1 expression is a frequent occurrence in poorly differentiated neuroendocrine carcinomas of the digestive system. Checkpoint blockade targeting the PD-1/PD-L1 pathway may have a potential role in treating patients with this disease. Copyright © 2017 Elsevier Inc. All rights reserved.

Mapping infectious disease hospital surge threats to lessons learnt in Singapore: a systems analysis and development of a framework to inform how to DECIDE on planning and response strategies.

Science.gov (United States)

Singh, Shweta R; Coker, Richard; Vrijhoef, Hubertus J-M; Leo, Yee Sin; Chow, Angela; Lim, Poh Lian; Tan, Qinghui; Chen, Mark I-Cheng; Hildon, Zoe Jane-Lara

2017-09-04

Hospital usage and service demand during an Infectious Disease (ID) outbreak can tax the health system in different ways. Herein we conceptualize hospital surge elements, and lessons learnt from such events, to help build appropriately matched responses to future ID surge threats. We used the Interpretive Descriptive qualitative approach. Interviews (n = 35) were conducted with governance and public health specialists; hospital based staff; and General Practitioners. Key policy literature in tandem with the interview data were used to iteratively generate a Hospital ID Surge framework. We anchored our narrative account within this framework, which is used to structure our analysis. A spectrum of surge threats from combinations of capacity (for crowding) and capability (for treatment complexity) demands were identified. Starting with the Pyramid scenario, or an influx of high screening rates flooding Emergency Departments, alongside fewer and manageable admissions; the Reverse-Pyramid occurs when few cases are screened and admitted but those that are, are complex; during a 'Black' scenario, the system is overburdened by both crowding and complexity. The Singapore hospital system is highly adapted to crowding, functioning remarkably well at constant near-full capacity in Peacetime and resilient to Endemic surges. We catalogue 26 strategies from lessons learnt relating to staffing, space, supplies and systems, crystalizing institutional memory. The DECIDE model advocates linking these strategies to types of surge threats and offers a step-by-step guide for coordinating outbreak planning and response. Lack of a shared definition and decision making of surge threats had rendered the procedures somewhat duplicative. This burden was paradoxically exacerbated by a health system that highly prizes planning and forward thinking, but worked largely in silo until an ID crisis hit. Many such lessons can be put into play to further strengthen our current hospital governance

Analysis of Storm Surge in Hong Kong

Science.gov (United States)

Kao, W. H.

2017-12-01

A storm surge is a type of coastal flood that is caused by low-pressure systems such as tropical cyclones. Storm surges caused by tropical cyclones can be very powerful and damaging, as they can flood coastal areas, and even destroy infrastructure in serious cases. Some serious cases of storm surges leading to more than thousands of deaths include Hurricane Katrina (2005) in New Orleans and Typhoon Haiyan (2013) in Philippines. Hong Kong is a coastal city that is prone to tropical cyclones, having an average of 5-6 tropical cyclones entering 500km range of Hong Kong per year. Storm surges have seriously damaged Hong Kong in the past, causing more than 100 deaths by Typhoon Wanda (1962), and leading to serious damage to Tai O and Cheung Chau by Typhoon Hagupit (2008). To prevent economic damage and casualties from storm surges, accurately predicting the height of storm surges and giving timely warnings to citizens is very important. In this project, I will be analyzing how different factors affect the height of storm surge, mainly using data from Hong Kong. These factors include the windspeed in Hong Kong, the atmospheric pressure in Hong Kong, the moon phase, the wind direction, the intensity of the tropical cyclone, distance between the tropical cyclone and Hong Kong, the direction of the tropical cyclone relative to Hong Kong, the speed of movement of the tropical cyclone and more. My findings will also be compared with cases from other places, to see if my findings also apply for other places.

Numerical Evaluation of Storm Surge Indices for Public Advisory Purposes

Science.gov (United States)

Bass, B.; Bedient, P. B.; Dawson, C.; Proft, J.

2016-12-01

After the devastating hurricane season of 2005, shortcomings with the Saffir-Simpson Hurricane Scale's (SSHS) ability to characterize a tropical cyclones potential to generate storm surge became widely apparent. As a result, several alternative surge indices were proposed to replace the SSHS, including Powell and Reinhold's Integrated Kinetic Energy (IKE) factor, Kantha's Hurricane Surge Index (HSI), and Irish and Resio's Surge Scale (SS). Of the previous, the IKE factor is the only surge index to-date that truly captures a tropical cyclones integrated intensity, size, and wind field distribution. However, since the IKE factor was proposed in 2007, an accurate assessment of this surge index has not been performed. This study provides the first quantitative evaluation of the IKEs ability to serve as a predictor of a tropical cyclones potential surge impacts as compared to other alternative surge indices. Using the tightly coupled ADvanced CIRCulation and Simulating WAves Nearshore models, the surge and wave responses of Hurricane Ike (2008) and 78 synthetic tropical cyclones were evaluated against the SSHS, IKE, HSI and SS. Results along the upper TX coast of the Gulf of Mexico demonstrate that the HSI performs best in capturing the peak surge response of a tropical cyclone, while the IKE accounting for winds greater than tropical storm intensity (IKETS) provides the most accurate estimate of a tropical cyclones regional surge impacts. These results demonstrate that the appropriate selection of a surge index ultimately depends on what information is of interest to be conveyed to the public and/or scientific community.

Dermal fibroblasts from patients with Parkinson’s disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations [version 2; referees: 2 approved

Directory of Open Access Journals (Sweden)

Lucy M Collins

2018-02-01

Full Text Available Background: Recently, the development of Parkinson’s disease (PD has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA mutations. Methods: We investigated PD and Gaucher Disease (GD patient derived skin fibroblasts using biochemistry assays. Results: PD patient derived skin fibroblasts have normal glucocerebrosidase (GCase activity, whilst patients with PD and GBA mutations have a selective deficit in GCase enzyme activity and impaired autophagic flux. Conclusions: This data suggests that only PD patients with a GBA mutation have altered GCase activity and autophagy, which may explain their more rapid clinical progression.

Surge Protection in Low-Voltage AC Power Circuits: An Anthology

Science.gov (United States)

Martzloff, F. D.

2002-10-01

The papers included in this part of the Anthology provide basic information on the propagation of surges in low-voltage AC power circuits. The subject was approached by a combination of experiments and theoretical considerations. One important distinction is made between voltage surges and current surges. Historically, voltage surges were the initial concern. After the introduction and widespread use of current-diverting surge-protective devices at the point-of-use, the propagation of current surges became a significant factor. The papers included in this part reflect this dual dichotomy of voltage versus current and impedance mismatch effects versus simple circuit theory.

Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade

Directory of Open Access Journals (Sweden)

Ikebuchi Ryoyo

2011-09-01

Full Text Available Abstract The inhibitory receptor programmed death-1 (PD-1 and its ligand, programmed death-ligand 1 (PD-L1 are involved in immune evasion mechanisms for several pathogens causing chronic infections. Blockade of the PD-1/PD-L1 pathway restores anti-virus immune responses, with concomitant reduction in viral load. In a previous report, we showed that, in bovine leukemia virus (BLV infection, the expression of bovine PD-1 is closely associated with disease progression. However, the functions of bovine PD-L1 are still unknown. To investigate the role of PD-L1 in BLV infection, we identified the bovine PD-L1 gene, and examined PD-L1 expression in BLV-infected cattle in comparison with uninfected cattle. The deduced amino acid sequence of bovine PD-L1 shows high homology to the human and mouse PD-L1. The proportion of PD-L1 positive cells, especially among B cells, was upregulated in cattle with the late stage of the disease compared to cattle at the aleukemic infection stage or uninfected cattle. The proportion of PD-L1 positive cells correlated positively with prediction markers for the progression of the disease such as leukocyte number, virus load and virus titer whilst on the contrary, it inversely correlated with the degree of interferon-gamma expression. Blockade of the PD-1/PD-L1 pathway in vitro by PD-L1-specific antibody upregulated the production of interleukin-2 and interferon-gamma, and correspondingly, downregulated the BLV provirus load and the proportion of BLV-gp51 expressing cells. These data suggest that PD-L1 induces immunoinhibition in disease progressed cattle during chronic BLV infection. Therefore, PD-L1 would be a potential target for developing immunotherapies against BLV infection.

Kawasaki disease with G6PD deficiency--report of one case and literature review.

Science.gov (United States)

Chen, Chia-Hao; Lin, Li-Yan; Yang, Kuender D; Hsieh, Kai-Sheng; Kuo, Ho-Chang

2014-06-01

Kawasaki disease (KD) is a systemic vasculitis primarily affecting children who are younger than 5 years. The most serious complications are coronary artery aneurysms and sequelae of vasculitis with the subsequent development of coronary artery aneurysm. According to the literature, intravenous immunoglobulin (IVIG) plus high-dose aspirin (acetylsalicylic acid) were standard treatment for KD, whereas low-dose aspirin (3-5 mg/kg/day) was used for thrombocytosis in KD via antiplatelet effect. However, aspirin has been reported to have hemolytic potential in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a child with G6PD-deficiency who has KD, and review the literature. Copyright © 2012. Published by Elsevier B.V.

Volume-based characterization of postocclusion surge.

Science.gov (United States)

Zacharias, Jaime; Zacharias, Sergio

2005-10-01

To propose an alternative method to characterize postocclusion surge using a collapsible artificial anterior chamber to replace the currently used rigid anterior chamber model. Fundación Oftamológica Los Andes, Santiago, Chile. The distal end of a phacoemulsification handpiece was placed inside a compliant artificial anterior chamber. Digital recordings of chamber pressure, chamber volume, inflow, and outflow were performed during occlusion break of the phacoemulsification tip. The occlusion break profile of 2 different consoles was compared. Occlusion break while using a rigid anterior chamber model produced a simultaneous increase of chamber inflow and outflow. In the rigid chamber model, pressure decreased sharply, reaching negative pressure values. Alternatively, with the collapsible chamber model, a delay was observed in the inflow that occurs to compensate the outflow surge. Also, the chamber pressure drop was smaller in magnitude, never undershooting below atmospheric pressure into negative values. Using 500 mm Hg as vacuum limit, the Infiniti System (Alcon) performed better that the Legacy (Alcon), showing an 18% reduction in peak volume variation. The collapsible anterior chamber model provides a more realistic representation of the postocclusion surge events that occur in the real eye during cataract surgery. Peak volume fluctuation (mL), half volume recovery time(s), and volume fluctuation integral value (mL x s) are proposed as realistic indicators to characterize the postocclusion surge performance. These indicators show that the Infiniti System has a better postocclusion surge behavior than the Legacy System.

Observing Storm Surges from Space: A New Opportunity

Science.gov (United States)

Han, Guoqi; Ma, Zhimin; Chen, Dake; de Young, Brad; Chen, Nancy

2013-04-01

Coastal tide gauges can be used to monitor variations of a storm surge along the coast, but not in the cross-shelf direction. As a result, the cross-shelf structure of a storm surge has rarely been observed. In this study we focus on Hurricane Igor-induced storm surge off Newfoundland, Canada. Altimetric observations at about 2:30, September 22, 2010 UTC (hours after the passage of Hurricane Igor) reveal prominent cross-shelf variation of sea surface height during the storm passage, including a large nearshore slope and a mid-shelf depression. A significant coastal surge of 1 m derived from satellite altimetry is found to be consistent with tide-gauge measurements at nearby St. John's station. The post-storm sea level variations at St. John's and Argentia are argued to be associated with free equatorward-propagating continental shelf waves (with phase speeds of 11-13 m/s), generated along the northeast Newfoundland coast hours after the storm moved away from St. John's. The cross-shelf e-folding scale of the shelf wave was estimated to be ~100 km. We further show approximate agreement of altimetric and tide-gauge observations in the Gulf of Mexico during Hurricane Katrina (2005) and Isaac (2012). The study for the first time in the literature shows the robustness of satellite altimetry to observe storm surges, complementing tide-gauge observations for the analysis of storm surge characteristics and for the validation and improvement of storm surge models.

Surge flow irrigation under short field conditions in Egypt

NARCIS (Netherlands)

Ismail, S.M.; Depeweg, H.; Schultz, E.

2004-01-01

Several studies carried out in long furrows have shown that surge flow irrigation offers the potential of increasing the efficiency of irrigation. The effects of surge flow in short fields, such as in Egypt, are still not well known, however. To investigate the effect of surge flow irrigation in

Validation of a surge model by full scale testing

NARCIS (Netherlands)

Smeulers, J.P.M.; Gonzalez Díez, N.; Slot, H.J.

2012-01-01

Surge of turbo compressors can cause large almost step like changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. In spite of an anti-surge controller (ASC), at extreme events surge cycles may occur. In order to

Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis.

Science.gov (United States)

Birtas Atesoglu, Elif; Tarkun, Pinar; Demirsoy, Esra Terzi; Geduk, Ayfer; Mehtap, Ozgur; Batman, Adnan; Kaya, Fatih; Cekmen, Mustafa Baki; Gulbas, Zafer; Hacıhanefioglu, Abdullah

2016-04-01

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by dysregulation of T cells. Programmed death (PD) 1 and programmed death 1 ligand 1 (PD-L1) are cosignaling molecules, and the major role of the PD-1 pathway is the inhibition of self-reactive T cells and to protect against autoimmune diseases. We measured levels of serum soluble PD 1 (sPD-1) and serum soluble PD-L1 (sPD-L1) in 67 patients with ITP (24 newly diagnosed ITP [ndITP], 43 chronic ITP [cITP]) and 21 healthy controls (HCs). We determined decreased serum sPD-1 levels both in patients with ndITP and in patients with cITP when compared to HC. Moreover, there was a positive correlation between sPD-1 levels and platelet counts. The sPD-L1 levels were decreased in patients with ndITP when compared to patients with cITP. This is the first study investigating PD-1 signaling pathway in ITP. Decreased sPD-1 levels may have a role in ITP pathogenesis as without the inhibitory regulation of PD-1, sustained activation of T cells may cause inflammatory responses which is the case in ITP. © The Author(s) 2014.

Active surge control for variable speed axial compressors.

Science.gov (United States)

Lin, Shu; Yang, Chunjie; Wu, Ping; Song, Zhihuan

2014-09-01

This paper discusses active surge control in variable speed axial compressors. A compression system equipped with a variable area throttle is investigated. Based on a given compressor model, a fuzzy logic controller is designed for surge control and a proportional speed controller is used for speed control. The fuzzy controller uses measurements of the change of pressure rise as well as the change of mass flow to determine the throttle opening. The presented approach does not require the knowledge of system equilibrium or the surge line. Numerical simulations show promising results. The proposed fuzzy logic controller performs better than a backstepping controller and is capable to suppress surge at different operating points. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

Reconnaissance level study Mississippi storm surge barrier

NARCIS (Netherlands)

Van Ledden, M.; Lansen, A.J.; De Ridder, H.A.J.; Edge, B.

2012-01-01

This paper reports a reconnaissance level study of a storm surge barrier in the Mississippi River. Historical hurricanes have shown storm surge of several meters along the Mississippi River levees up to and upstream of New Orleans. Future changes due to sea level rise and subsidence will further

Surge analysis of the MAGLEV coil for propulsion and guidance; Jiki fujoshiki tetsudo ni okeru suitei annaiyo coil no surge kaiseki

Energy Technology Data Exchange (ETDEWEB)

Ema, S [Numazu College of Technology, Shizuoka (Japan)

1995-11-20

The MAGLEV (magnetically levitated train) is now well along in development testing in Japan. MAGLEV is unlike conventional railways, so various problems lie in the technology of MAGLEV. One of them is surge analysis of the MAGLEV coil for propulsion and guidance (`coil for propulsion` for short). The coil for propulsion is installed on each side of the outdoor guideway. Thus, the power system of MAGLEV is always exposed to lightning and circuit switching. Accordingly, it is very important to do a rational insulation plan to prevent damage when surges enter the coils. In view of this situation I performed experiments using the mini model coils and clarified impulse voltage distribution at the end of each coil and simulated the surge characteristics by giving the inverted L equivalent circuit to the coil for propulsion. As a result, the measured values and calculated values were almost equal in the surge characteristics. Further, the surge characteristics of the Miyazaki test track and the future MAGLEV were examined. 10 refs., 17 figs., 1 tab.

Artificial Neural Network forecasting of storm surge water levels at major estuarine ports to supplement national tide-surge models and improve port resilience planning

Science.gov (United States)

French, Jon; Mawdsley, Robert; Fujiyama, Taku; Achuthan, Kamal

2017-04-01

Effective prediction of tidal storm surge is of considerable importance for operators of major ports, since much of their infrastructure is necessarily located close to sea level. Storm surge inundation can damage critical elements of this infrastructure and significantly disrupt port operations and downstream supply chains. The risk of surge inundation is typically approached using extreme value analysis, while short-term forecasting generally relies on coastal shelf-scale tide and surge models. However, extreme value analysis does not provide information on the duration of a surge event and can be sensitive to the assumptions made and the historic data available. Also, whilst regional tide and surge models perform well along open coasts, their fairly coarse spatial resolution means that they do not always provide accurate predictions for estuarine ports. As part of a NERC Environmental Risks to Infrastructure Innovation Programme project, we have developed a tool that is specifically designed to forecast the North Sea storm surges on major ports along the east coast of the UK. Of particular interest is the Port of Immingham, Humber estuary, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. A tidal surge in December 2013, with an estimated return period of 760 years, partly flooded the port, damaged infrastructure and disrupted operations for several weeks. This and other recent surge events highlight the need for additional tools to supplement the national UK Storm Tide Warning Service. Port operators are also keen to have access to less computationally expensive forecasting tools for scenario planning and to improve their resilience to actual events. In this paper, we demonstrate the potential of machine learning methods based on Artificial Neural Networks (ANNs) to generate accurate short-term forecasts of extreme water levels at estuarine North Sea ports such as Immingham. An ANN is

Inter-rater variability in motor function assessment in Parkinson's disease between experts in movement disorders and nurses specialising in PD management.

Science.gov (United States)

de Deus Fonticoba, T; Santos García, D; Macías Arribí, M

2017-05-23

In clinical practice, assessing patients with Parkinson's disease (PD) is a complex, time-consuming task. Our purpose is to provide a rigorous and objective evaluation of how motor function in PD patients is assessed by neurologists specialising in movement disorders, on the one hand, and by nurses specialising in PD management, on the other. We conducted an observational, cross-sectional, single-centre study of 50 patients with PD (52% men; mean age: 64.7 ± 8.7 years) who were assessed between 5 January 2016 and 20 July 2016. A neurologist and a nurse evaluated motor function in the early morning hours using the Unified Parkinson's Disease Rating Scale (UPDRS) parts III and IV and Hoehn & Yahr (H&Y) scale. Tests were administered in the same PD periods (in 48 patients during the 'off' time and in 2 patients during the 'on' time). Inter-rater variability was estimated with the intraclass correlation coefficient (ICC). Forty-nine patients (98%) were classified in the same H&Y stage by both raters. Assessment times were similar for both raters. ICC for UPDRS-IV and UPDRS-III total scores were 0.955 (Pde Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Characterization of the Xylella fastidiosa PD1671 gene encoding degenerate c-di-GMP GGDEF/EAL domains, and its role in the development of Pierce's disease.

Science.gov (United States)

Cursino, Luciana; Athinuwat, Dusit; Patel, Kelly R; Galvani, Cheryl D; Zaini, Paulo A; Li, Yaxin; De La Fuente, Leonardo; Hoch, Harvey C; Burr, Thomas J; Mowery, Patricia

2015-01-01

Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce's disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of cell aggregates and bacterial biofilms. Here we examine the role in X. fastidiosa virulence of an uncharacterized gene, PD1671, annotated as a two-component response regulator with potential GGDEF and EAL domains. GGDEF domains are found in c-di-GMP diguanylate cyclases while EAL domains are found in phosphodiesterases, and these domains are for c-di-GMP production and turnover, respectively. Functional analysis of the PD1671 gene revealed that it affected multiple X. fastidiosa virulence-related phenotypes. A Tn5 PD1671 mutant had a hypervirulent phenotype in grapevines presumably due to enhanced expression of gum genes leading to increased exopolysaccharide levels that resulted in elevated biofilm formation. Interestingly, the PD1671 mutant also had decreased motility in vitro but did not show a reduced distribution in grapevines following inoculation. Given these responses, the putative PD1671 protein may be a negative regulator of X. fastidiosa virulence.

Characterization of the Xylella fastidiosa PD1671 gene encoding degenerate c-di-GMP GGDEF/EAL domains, and its role in the development of Pierce's disease.

Directory of Open Access Journals (Sweden)

Luciana Cursino

Full Text Available Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce's disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of cell aggregates and bacterial biofilms. Here we examine the role in X. fastidiosa virulence of an uncharacterized gene, PD1671, annotated as a two-component response regulator with potential GGDEF and EAL domains. GGDEF domains are found in c-di-GMP diguanylate cyclases while EAL domains are found in phosphodiesterases, and these domains are for c-di-GMP production and turnover, respectively. Functional analysis of the PD1671 gene revealed that it affected multiple X. fastidiosa virulence-related phenotypes. A Tn5 PD1671 mutant had a hypervirulent phenotype in grapevines presumably due to enhanced expression of gum genes leading to increased exopolysaccharide levels that resulted in elevated biofilm formation. Interestingly, the PD1671 mutant also had decreased motility in vitro but did not show a reduced distribution in grapevines following inoculation. Given these responses, the putative PD1671 protein may be a negative regulator of X. fastidiosa virulence.

Storm surge and wave simulations in the Gulf of Mexico using a consistent drag relation for atmospheric and storm surge models

Directory of Open Access Journals (Sweden)

D. Vatvani

2012-07-01

Full Text Available To simulate winds and water levels, numerical weather prediction (NWP and storm surge models generally use the traditional bulk relation for wind stress, which is characterized by a wind drag coefficient. A still commonly used drag coefficient in those models, some of them were developed in the past, is based on a relation, according to which the magnitude of the coefficient is either constant or increases monotonically with increasing surface wind speed (Bender, 2007; Kim et al., 2008; Kohno and Higaki, 2006. The NWP and surge models are often tuned independently from each other in order to obtain good results. Observations have indicated that the magnitude of the drag coefficient levels off at a wind speed of about 30 m s⁻¹, and then decreases with further increase of the wind speed. Above a wind speed of approximately 30 m s⁻¹, the stress above the air-sea interface starts to saturate. To represent the reducing and levelling off of the drag coefficient, the original Charnock drag formulation has been extended with a correction term.

In line with the above, the Delft3D storm surge model is tested using both Charnock's and improved Makin's wind drag parameterization to evaluate the improvements on the storm surge model results, with and without inclusion of the wave effects. The effect of waves on storm surge is included by simultaneously simulating waves with the SWAN model on identical model grids in a coupled mode. However, the results presented here will focus on the storm surge results that include the wave effects.

The runs were carried out in the Gulf of Mexico for Katrina and Ivan hurricane events. The storm surge model was initially forced with H^*wind data (Powell et al., 2010 to test the effect of the Makin's wind drag parameterization on the storm surge model separately. The computed wind, water levels and waves are subsequently compared with observation data. Based on the good

Pressure-surge mitigation methods in fluid-conveying piping

International Nuclear Information System (INIS)

Shin, Y.W.; Youngdahl, C.K.; Wiedermann, A.H.

1991-01-01

Pressure surges in the heat transport system of nuclear reactor plants can affect the safety and reliability of the plants. Hence the pressure surges must be considered in the design, operation, and maintenance of the plants in order to minimize their occurrence and impacts. The objectives of this paper are to review various methods to control or mitigate the pressure surges, to analyze these methods to gain understanding of the mitigation mechanisms, and examine applicability of the methods to nuclear power plants. 6 refs., 13 figs

Performance of Surge Arrester Installation to Enhance Protection

Directory of Open Access Journals (Sweden)

Mbunwe Muncho Josephine

2017-01-01

Full Text Available The effects of abnormal voltages on power system equipment and appliances in the home have raise concern as most of the equipments are very expensive. Each piece of electrical equipment in an electrical system needs to be protected from surges. To prevent damage to electrical equipment, surge protection considerations are paramount to a well designed electrical system. Lightning discharges are able to damage electric and electronic devices that usually have a low protection level and these are influenced by current or voltage pulses with a relatively low energy, which are induced by lightning currents. This calls for proper designed and configuration of surge arresters for protection on the particular appliances. A more efficient non-linear surge arrester, metal oxide varistor (MOV, should be introduced to handle these surges. This paper shows the selection of arresters laying more emphasis on the arresters for residential areas. In addition, application and installation of the arrester will be determined by the selected arrester. This paper selects the lowest rated surge arrester as it provides insulation when the system is under stress. It also selected station class and distribution class of arresters as they act as an open circuit under normal system operation and to bring the system back to its normal operation mode as the transient voltage is suppressed. Thus, reduces the risk of damage, which the protection measures can be characterized, by the reduction value of the economic loss to an acceptable level.

Harmful effects of lightning surge discharge on communications terminal equipments

International Nuclear Information System (INIS)

Liang, Sisi; Xu, Xiaoying; Tao, Zhigang; Dai, Yanling

2013-01-01

The interference problem of lightning surges on electronic and telecommunication products were examined, and a series of experiments were conducted to analyze the failure situations to find out the mechanisms of failures caused by the lightning surge. In addition, the ways in which lightning surges damaged equipment were deduced. It was found that failure positions were scattered and appeared in groups, and most of them were ground discharge. Internet access transformer had high withstand-voltage under the lightning pulse, and the lightning surge seldom passed through the internet access transformer. The lightning current can release to the ground via the computer network adapter of the terminal user. The study will help to improve the performance of lightning surge protection circuit and protection level.

Pre-swirl mechanism in front of a centrifugal compressor: effects on surge line and on unsteady phenomena in surge area

Directory of Open Access Journals (Sweden)

Danlos Amélie

2017-01-01

Full Text Available Using a pre-swirl mechanism upstream an impeller of a compressor allows to modify its characteristics curve, while weakly damaging its efficiency. Another consequence of the pre-swirl is to push back the surge line limit and to increase the operation zone towards the low flow rate limits. A centrifugal compressor has been modified in order to add a swirl generator device upstream the impeller. The incidence values of blades can vary from 0° (no pre-swirl to ±90°. The variation of the stator blades incidence has several main consequences: to allow a flow rate adjustment with a good efficiency conservation, to increase the angular velocity with a constant shaft power, to produce a displacement of the surge line limit. In this paper, the results of experimental studies are presented to analyze the surge line and the intensity of unsteady phenomena when the compressor works in its surge area.

The destruction influence of pulse and surge currents on overvoltage protection

International Nuclear Information System (INIS)

Glasa, M.; Huettner, L.

2012-01-01

This article deals about the influences caused during the active operation process of the surge arrester against the pulse and surge currents. It also refers about a lightning, the characteristic of lightning and about the lightning (surge) currents caused its influence. One parts of the article is focused on a total elimination of surge current energy, and on an ineffective operation, which leads to partially or totally destruction of a protection element. There is a comparison with two basic types of surge arresters (spark gap and varistor based arresters), and theirs re-effectiveness on prescribed level. (Authors)

Surge dynamics on Bering Glacier, Alaska, in 2008–2011

Directory of Open Access Journals (Sweden)

M. Braun

2012-11-01

Full Text Available A surge cycle of the Bering Glacier system, Alaska, is examined using observations of surface velocity obtained using synthetic aperture radar (SAR offset tracking, and elevation data obtained from the University of Alaska Fairbanks LiDAR altimetry program. After 13 yr of quiescence, the Bering Glacier system began to surge in May 2008 and had two stages of accelerated flow. During the first stage, flow accelerated progressively for at least 10 months and reached peak observed velocities of ~ 7 m d−1. The second stage likely began in 2010. By 2011 velocities exceeded 9 m d−1 or ~ 18 times quiescent velocities. Fast flow continued into July 2011. Surface morphology indicated slowing by fall 2011; however, it is not entirely clear if the surge is yet over. The quiescent phase was characterized by small-scale acceleration events that increased driving stresses up to 70%. When the surge initiated, synchronous acceleration occurred throughout much of the glacier length. Results suggest that downstream propagation of the surge is closely linked to the evolution of the driving stress during the surge, because driving stress appears to be tied to the amount of resistive stress provided by the bed. In contrast, upstream acceleration and upstream surge propagation is not dependent on driving stress evolution.

Compressor Surge Control Design Using Linear Matrix Inequality Approach

OpenAIRE

Uddin, Nur; Gravdahl, Jan Tommy

2017-01-01

A novel design for active compressor surge control system (ASCS) using linear matrix inequality (LMI) approach is presented and including a case study on piston-actuated active compressor surge control system (PAASCS). The non-linear system dynamics of the PAASCS is transformed into linear parameter varying (LPV) system dynamics. The system parameters are varying as a function of the compressor performance curve slope. A compressor surge stabilization problem is then formulated as a LMI probl...

Characterization of the Xylella fastidiosa PD1671 Gene Encoding Degenerate c-di-GMP GGDEF/EAL Domains, and Its Role in the Development of Pierce’s Disease

Science.gov (United States)

Cursino, Luciana; Athinuwat, Dusit; Patel, Kelly R.; Galvani, Cheryl D.; Zaini, Paulo A.; Li, Yaxin; De La Fuente, Leonardo; Hoch, Harvey C.; Burr, Thomas J.; Mowery, Patricia

2015-01-01

Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce’s disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of cell aggregates and bacterial biofilms. Here we examine the role in X. fastidiosa virulence of an uncharacterized gene, PD1671, annotated as a two-component response regulator with potential GGDEF and EAL domains. GGDEF domains are found in c-di-GMP diguanylate cyclases while EAL domains are found in phosphodiesterases, and these domains are for c-di-GMP production and turnover, respectively. Functional analysis of the PD1671 gene revealed that it affected multiple X. fastidiosa virulence-related phenotypes. A Tn5 PD1671 mutant had a hypervirulent phenotype in grapevines presumably due to enhanced expression of gum genes leading to increased exopolysaccharide levels that resulted in elevated biofilm formation. Interestingly, the PD1671 mutant also had decreased motility in vitro but did not show a reduced distribution in grapevines following inoculation. Given these responses, the putative PD1671 protein may be a negative regulator of X. fastidiosa virulence. PMID:25811864

Proposed Strategies for DWPF Melter Off-Gas Surge Control

International Nuclear Information System (INIS)

CHOI, ALEXANDERS.

2004-01-01

Off-gas surging is inherent to the operation of slurry-fed melters. Although the melter design and the feed chemistry are both known to significantly affect off-gas surging, the frequency and intensity of surges are in essence unpredictable. In typical off-gas surges, both condensable and non condensable flows spike simultaneously. Condensable or steam surges have been observed to occur as the boiling water layer occasionally falls into the crevices of the cold cap or flows over the edges of the cold cap, thereby coming in contact with the melt surface. The resulting steam surges can pressurize the melter considerably and, therefore, are responsible for the bulk of pressure transients that propagate throughout the off-gas system. The non condensable surges occur as the calcine gases that have been accumulating within the cold cap finally build up enough pressure to be released through the temporary openings of the cold cap. The analysis of off-gas data has shown that over 90 of the gas released during a surge is due to steam.1 Therefore, it is essential to have a large inventory of water in the cold cap for any significant pressure spikes to occur. With the Melter 2 vapor space temperature typically running at 720C, the water layer in the cold cap will quickly evaporate once the feeding stops, and the potential for any large pressure spikes should practically cease to exist. The analysis also showed that large pressure spikes well above 2 inches H2O cannot occur under the steam surge scenarios described above. More severe conditions should prevail and one such condition would be that the feed materials form a mound with a growing lake on top, while the melt below remains very fluidic due to its low viscosity, thus resulting in greater movements both in the lateral as well as vertical directions. Once the mound begins to grow, its rate should accelerate, since the heat transfer rate to the upper regions of the cold cap is inversely proportional to the cold cap

Overview and Design Considerations of Storm Surge Barriers

NARCIS (Netherlands)

Mooyaart, L.F.; Jonkman, S.N.

2017-01-01

The risk of flooding in coastal zones is expected to increase due to sea level rise and economic development. In larger bays, estuaries, and coastal waterways, storm surge barriers can be constructed to temporarily close off these systems during storm surges to provide coastal flood protection.

The Use of a Statistical Model of Storm Surge as a Bias Correction for Dynamical Surge Models and its Applicability along the U.S. East Coast

Directory of Open Access Journals (Sweden)

Haydee Salmun

2015-02-01

Full Text Available The present study extends the applicability of a statistical model for prediction of storm surge originally developed for The Battery, NY in two ways: I. the statistical model is used as a biascorrection for operationally produced dynamical surge forecasts, and II. the statistical model is applied to the region of the east coast of the U.S. susceptible to winter extratropical storms. The statistical prediction is based on a regression relation between the “storm maximum” storm surge and the storm composite significant wave height predicted ata nearby location. The use of the statistical surge prediction as an alternative bias correction for the National Oceanic and Atmospheric Administration (NOAA operational storm surge forecasts is shownhere to be statistically equivalent to the existing bias correctiontechnique and potentially applicable for much longer forecast lead times as well as for storm surge climate prediction. Applying the statistical model to locations along the east coast shows that the regression relation can be “trained” with data from tide gauge measurements and near-shore buoys along the coast from North Carolina to Maine, and that it provides accurate estimates of storm surge.

Improved PV system reliability results from surge evaluations at Sandia National Laboratories

International Nuclear Information System (INIS)

Russell H. Bonn; Sigifredo Gonzalez

2000-01-01

Electrical surges on ac and dc inverter power wiring and diagnostic cables have the potential to shorten the lifetime of power electronics. These surges may be caused by either nearby lightning or capacitor switching transients. This paper contains a description of ongoing surge evaluations of PV power electronics and surge mitigation hardware at Sandia

Young women with PD: a group work experience.

Science.gov (United States)

Posen, J; Moore, O; Tassa, D S; Ginzburg, K; Drory, M; Giladi, N

2000-01-01

Parkinson's Disease (PD) prior to the age of 40 affects between 5-10% of the PD population. The psychosocial changes that patients with early PD encounter, may be more devastating and disabling than the actual motor disability. The paper describes a unique experience in groupwork with young female PD patients treated in the Movement Disorders Unit of the Tel Aviv Sourasky Medical Center. The paper focuses on the special issues which characterized this group's experience: stigma, body and sexual image, and personality traits.

Storm surge model based on variational data assimilation method

Directory of Open Access Journals (Sweden)

Shi-li Huang

2010-06-01

Full Text Available By combining computation and observation information, the variational data assimilation method has the ability to eliminate errors caused by the uncertainty of parameters in practical forecasting. It was applied to a storm surge model based on unstructured grids with high spatial resolution meant for improving the forecasting accuracy of the storm surge. By controlling the wind stress drag coefficient, the variation-based model was developed and validated through data assimilation tests in an actual storm surge induced by a typhoon. In the data assimilation tests, the model accurately identified the wind stress drag coefficient and obtained results close to the true state. Then, the actual storm surge induced by Typhoon 0515 was forecast by the developed model, and the results demonstrate its efficiency in practical application.

The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study

Directory of Open Access Journals (Sweden)

Corbett Alastair

2008-11-01

Full Text Available Abstract Background We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2-related Parkinson's disease (PD in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser (G2019S, is associated with approximately 5 to 6% of familial PD cases and 1 to 2% of idiopathic cases, making it the most common known genetic cause of PD. Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD. Methods A sample, including 903 affected and 58 unaffected members from 509 families ascertained for having two or more PD-affected members, 126 randomly ascertained PD patients and 197 controls, was screened for five different LRRK2 mutations. Penetrance was estimated in families of LRRK2 carriers with consideration of the inherent bias towards increased penetrance in a familial sample. Results Thirty-one out of 509 families with multiple cases of PD (6.1% were found to have 58 LRRK2 mutation carriers (6.4%. Twenty-nine of the 31 families had G2019S mutations while two had R1441C mutations. No mutations were identified among controls or unaffected relatives of PD cases. Nine PD-affected relatives of G2019S carriers did not carry the LRRK2 mutation themselves. At the maximum observed age range of 90 to 94 years, the unbiased estimated penetrance was 67% for G2019S families, compared with a baseline PD risk of 17% seen in the non-LRRK2-related PD families. Conclusion Lifetime penetrance of LRRK2 estimated in the unascertained relatives of multiplex PD families is greater than that reported in studies of sporadically ascertained LRRK2 cases, suggesting that inherited susceptibility factors may modify the penetrance of LRRK2 mutations. In addition, the presence of nine PD phenocopies in the LRRK2 families suggests that these susceptibility

Surge of Bering Glacier and Bagley Ice Field: Parameterization of surge characteristics based on automated analysis of crevasse image data and laser altimeter data

Science.gov (United States)

Stachura, M.; Herzfeld, U. C.; McDonald, B.; Weltman, A.; Hale, G.; Trantow, T.

2012-12-01

The dynamical processes that occur during the surge of a large, complex glacier system are far from being understood. The aim of this paper is to derive a parameterization of surge characteristics that captures the principle processes and can serve as the basis for a dynamic surge model. Innovative mathematical methods are introduced that facilitate derivation of such a parameterization from remote-sensing observations. Methods include automated geostatistical characterization and connectionist-geostatistical classification of dynamic provinces and deformation states, using the vehicle of crevasse patterns. These methods are applied to analyze satellite and airborne image and laser altimeter data collected during the current surge of Bering Glacier and Bagley Ice Field, Alaska.

Effect of Tide Elevation on Extratropical Storm Surge in Northwest Europe

Science.gov (United States)

Keshtpoor, M.; Carnacina, I.; Yablonsky, R. M.

2016-12-01

Extratropical cyclones (ETCs) are the major storm surge-generating meteorological events in northwest Europe. The total water level increase induced by these ETCs is significantly influenced by the local tidal range, which exceeds 8 meters along the southwestern UK coastline. In particular, a surge-generating ETC during high tide may put coastal assets and infrastructure in risk. Also, during low tide, the risk of surge induced by extreme ETC events is diminished. Here, the effect of tidal elevation on storm surge is investigated at 196 tide gauges in northwest Europe. A numerical, hydrodynamic model was developed using Delft3D-FM framework to simulate the coastal hydrodynamics during ETCs. Then, 1750 historical events were simulated to investigate the pattern of coastal inundation. Results suggest that in areas with a large tidal range ( 8 meters) and during the time period surrounding high or low tide, the pattern of coastal hydrodynamics is governed by tide and not storm surge. This result is most evident near the English Channel and Bristol Channel, where low frequency maximum water levels are observed when storm surge is combined with high tide. In contrast, near the tidal phase reversal, coastal hydrodynamics responds primarily to the storm surge, and low frequency maximum water elevation largely depends on the surge. In the areas with a small tidal range, ETC strength determines the pattern of coastal inundation.

Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita

Science.gov (United States)

Gesch, Dean B.

2009-01-01

The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

Objective measurement of postocclusion surge during phacoemulsification in human eye-bank eyes.

Science.gov (United States)

Georgescu, Dan; Payne, Marielle; Olson, Randall J

2007-03-01

To objectively compare the postocclusion vacuum surge among different phacoemulsification machines and devices. Experimental study. Infiniti, Legacy, Millennium, and Sovereign were tested in an eye-bank eye. All the machines were tested with 20-gauge non-ABS tips, 430 mm Hg vacuum pressure, 24 ml/minute aspiration rate, peristaltic pump, and 75 cm bottle height. In addition, Infiniti and Legacy were also tested with 20-gauge bypass tips (ABS), 125 cm bottle height, and 40 ml/minute flow rate. We also tested 19-gauge tips with Infiniti and Sovereign and the venturi pump for Millennium. Significant differences were found between all the machines tested with Millennium peristaltic generating the least and Millennium Venturi the most surge. ABS tips significantly decreased the surge for Legacy but not for Infiniti. Cruise Control (CC) had a significant effect on Sovereign but not on Millennium. Increasing the bottle height decreased surge while increasing the flow increased surge for both Infiniti and Legacy. The 19-gauge tips increased surge for both Infiniti and Sovereign. Surge varied over a range of 40 microm to more than 2 mm. ABS and CC decrease surge, especially when the machine is not functioning near the limits of surge prevention. Certain parameters, such as a 19-gauge tip and high flow, dramatically increased surge, whereas elevating the bottle ameliorates it. Understanding the impact of all these features will help in minimizing the problem.

Risk assessment of storm surge disaster based on numerical models and remote sensing

Science.gov (United States)

Liu, Qingrong; Ruan, Chengqing; Zhong, Shan; Li, Jian; Yin, Zhonghui; Lian, Xihu

2018-06-01

Storm surge is one of the most serious ocean disasters in the world. Risk assessment of storm surge disaster for coastal areas has important implications for planning economic development and reducing disaster losses. Based on risk assessment theory, this paper uses coastal hydrological observations, a numerical storm surge model and multi-source remote sensing data, proposes methods for valuing hazard and vulnerability for storm surge and builds a storm surge risk assessment model. Storm surges in different recurrence periods are simulated in numerical models and the flooding areas and depth are calculated, which are used for assessing the hazard of storm surge; remote sensing data and GIS technology are used for extraction of coastal key objects and classification of coastal land use are identified, which is used for vulnerability assessment of storm surge disaster. The storm surge risk assessment model is applied for a typical coastal city, and the result shows the reliability and validity of the risk assessment model. The building and application of storm surge risk assessment model provides some basis reference for the city development plan and strengthens disaster prevention and mitigation.

Identification of Storm Surge Vulnerable Areas in the Philippines Through Simulations of Typhoon Haiyan-Induced Storm Surge Using Tracks of Historical Tropical Cyclones

Science.gov (United States)

Lapidez, John Phillip; Suarez, John Kenneth; Tablazon, Judd; Dasallas, Lea; Gonzalo, Lia Anne; Santiago, Joy; Cabacaba, Krichi May; Ramos, Michael Marie Angelo; Mahar Francisco Lagmay, Alfredo; Malano, Vicente

2014-05-01

Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR) 07 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the typhoon's storm surge and strong winds. Storm surges up to a height of 7 meters were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards, the flagship disaster mitigation program of the Department of Science and Technology, Government of the Philippines, to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948-2013. DOST-Project NOAH used the Japan Meteorological Agency (JMA) Storm Surge Model, a numerical code that simulates and predicts storm surges spawned by tropical cyclones. Input parameters for the storm surge model include bathymetric data, storm track, central atmospheric pressure, and maximum wind speed. The simulations were made using Haiyan's pressure and wind speed as the forcing parameters. The simulated storm surge height values were added to the maximum tide level obtained from WXTide, software that contains a catalogue of worldwide astronomical tides, to come up with storm tide levels. The resulting water level was used as input to FLO-2D to generate the storm tide inundation maps. One product of this study is a list of the most vulnerable coastal areas that can be used as basis for choosing priority sites for further studies to implement appropriate site-specific solutions. Another product is the storm tide inundation maps that the local government units can use to develop a Risk-Sensitive Land Use Plan for identifying appropriate areas to build residential buildings

Predicting Typhoon Induced Storm Surges Using the Operational Ocean Forecast System

Directory of Open Access Journals (Sweden)

Sung Hyup You

2010-01-01

Full Text Available This study was performed to compare storm surges simulated by the operational storm surges/tide forecast system (STORM : Storm surges/Tide Operational Model of the Korea Meteorological Administration (KMA with observations from 30 coastal tidal stations during nine typhoons that occurred between 2005 and 2007. The results (bias showed that for cases of overestimation (or underestimation, storm surges tended to be overestimated (as well as underestimated at all coastal stations. The maximum positive bias was approximately 6.92 cm for Typhoon Ewiniar (2006, while the maximum negative bias was approximately -12.06 cm for Typhoon Khanun (2005. The maximum and minimum root mean square errors (RMSEs were 14.61 and 6.78 cm, which occurred for Typhoons Khanun (2005 and Usagi (2007, respectively. For all nine typhoons, total averaged RMSE was approximately 10.2 cm. Large differences between modeled and observed storm surges occurred in two cases. In the first, a very weak typhoon, such as Typhoon Khanun (2005, caused low storm surges. In the other, exemplified by Typhoon Nari (2007, there were errors in the predicted typhoon strength used as input data for the storm surge model.

Present dynamics and future prognosis of a slowly surging glacier

Directory of Open Access Journals (Sweden)

G. E. Flowers

2011-03-01

Full Text Available Glacier surges are a well-known example of an internal dynamic oscillation whose occurrence is not a direct response to the external climate forcing, but whose character (i.e. period, amplitude, mechanism may depend on the glacier's environmental or climate setting. We examine the dynamics of a small (∼5 km² valley glacier in Yukon, Canada, where two previous surges have been photographically documented and an unusually slow surge is currently underway. To characterize the dynamics of the present surge, and to speculate on the future of this glacier, we employ a higher-order flowband model of ice dynamics with a regularized Coulomb-friction sliding law in both diagnostic and prognostic simulations. Diagnostic (force balance calculations capture the measured ice-surface velocity profile only when non-zero basal water pressures are prescribed over the central region of the glacier, coincident with where evidence of the surge has been identified. This leads to sliding accounting for 50–100% of the total surface motion in this region. Prognostic simulations, where the glacier geometry evolves in response to a prescribed surface mass balance, reveal a significant role played by a bedrock ridge beneath the current equilibrium line of the glacier. Ice thickening occurs above the ridge in our simulations, until the net mass balance reaches sufficiently negative values. We suggest that the bedrock ridge may contribute to the propensity for surges in this glacier by promoting the development of the reservoir area during quiescence, and may permit surges to occur under more negative balance conditions than would otherwise be possible. Collectively, these results corroborate our interpretation of the current glacier flow regime as indicative of a slow surge that has been ongoing for some time, and support a relationship between surge incidence or character and the net mass balance. Our results also highlight the importance of glacier bed

30 CFR 56.16002 - Bins, hoppers, silos, tanks, and surge piles.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bins, hoppers, silos, tanks, and surge piles... MINES Materials Storage and Handling § 56.16002 Bins, hoppers, silos, tanks, and surge piles. (a) Bins, hoppers, silos, tanks, and surge piles, where loose unconsolidated materials are stored, handled or...

30 CFR 57.16002 - Bins, hoppers, silos, tanks, and surge piles.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bins, hoppers, silos, tanks, and surge piles... NONMETAL MINES Materials Storage and Handling § 57.16002 Bins, hoppers, silos, tanks, and surge piles. (a) Bins, hoppers, silos, tanks, and surge piles, where loose unconsolidated materials are stored, handled...

Sleep disturbances in drug naïve Parkinson′s disease (PD patients and effect of levodopa on sleep

Directory of Open Access Journals (Sweden)

Teresa Ferreira

2014-01-01

Full Text Available Context: Parkinson′s disease (PD is associated with sleep disturbances, attributed to the neurodegenerative process and therapeutic drugs. Studies have found levodopa to increase wakefulness in some patients while increasing sleepiness in others. Aims: To confirm sleep disturbances in drug naïve PD patients and understand the impact of levodopa on their sleep. Materials and Methods: Twenty-three drug naοve PD patients and 31 age-gender matched controls were compared using the Parkinson′s Disease Sleep Scale (PDSS and Epworth Sleepiness Scale (ESS. A polysomnogram objectively compared sleep quality. Of the 23 patients, the 12 initiated on levodopa were reassessed subjectively and through polysomnography after 2 months of therapy. Statistical Analysis: Data was expressed as mean ± standard deviation, median, and range. Continuous variables were analyzed by Student′s T test for normally distributed data and Mann-Whitney U test for skewed data. Discrete variables were compared by Chi Square tests (Pearson Chi square Test or Fisher′s Exact Test. Wilcoxon signed ranks test was applied in the analysis of paired data pre- and post-levodopa. A P value < 0.05 was considered as statistically significant. Statistical analysis of the data was done using the Statistical Package for the Social Sciences (SPSS version 12. Results: Drug naïve PD patients had lower PDSS scores than controls. The sleep architecture changes observed on polysomnogram were reduced NREM Stage III and REM sleep and increased sleep latency and wake after sleep onset time. Following levodopa, improved sleep efficiency with reduced sleep latency and wake after sleep onset time was noted, coupled with improved PDSS scores. However, NREM Stage III and REM sleep duration did not increase. Discussion: PD patients take longer to fall asleep and have difficulty in sleep maintenance. Sleep maintenance is affected by nocturia, REM behavioral disorder, nocturnal cramps, akinesia, and

The nocturnal thyroid-stimulating hormone surge is absent in overt, present in mild primary and equivocal in central hypothyroidism

NARCIS (Netherlands)

Adriaanse, R.; Romijn, J. A.; Endert, E.; Wiersinga, W. M.

1992-01-01

The nocturnal TSH surge was studied in controls, in 34 patients with hypothalamic/pituitary disease and in 21 patients with primary hypothyroidism. It was absent in 5/12 hypothyroid patients and in 5/22 euthyroid patients with hypothalamic/pituitary disease (42% vs 23%, NS). Central hypothyroidism

Surge recovery techniques for the Tevatron cold compressors

International Nuclear Information System (INIS)

Martinez, A.; Klebaner, A.L.; Makara, J.N.; Theilacker, J.C.; Fermilab

2006-01-01

The Fermilab Tevatron cryogenic system utilizes high-speed centrifugal cold compressors, made by Ishikawajima-Harima Heavy Industries Co. Ltd. (IHI), for high-energy operations [1]. The compressor is designed to pump 60 g/s of 3.6 K saturated helium vapor at a pressure ratio of 2.8, with an off-design range of 40 to 70 g/s and operating speeds between 40 and 95 krpm. Since initial commissioning in 1993, Tevatron transient conditions such as quench recovery have led to multiple-location machine trips as a result of the cold compressors entering the surge regime. Historically, compressors operating at lower inlet pressures and higher speeds have been especially susceptible to these machine trips and it was not uncommon to have multiple compressor trips during large multiple-house quenches. In order to cope with these events and limit accelerator down time, surge recovery techniques have been implemented in an attempt to prevent the compressors from tripping once the machine entered this surge regime. This paper discusses the different methods of surge recovery that have been employed. Data from tests performed at the Cryogenic Test Facility at Fermilab as well as actual Tevatron operational data were utilized. In order to aid in the determination of the surge region, a full mapping study was undertaken to characterize the entire pressure field of the cold compressor. These techniques were then implemented and tested at several locations in the Tevatron with some success

Multilevel analysis of clinical parameters in chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results

Directory of Open Access Journals (Sweden)

Ibrahimu Mdala

2012-04-01

Full Text Available Aim: Find the periodontal treatment that best maintained clinical results over time evaluated by changes in pocket depth (PD and clinical attachment level (CAL. Methods: 229 patients with chronic periodontitis from USA (n=134 and Sweden (n=95 were randomly assigned to eight groups receiving 1 scaling+root planing (SRP alone or combined with 2 surgery (SURG+systemic amoxicillin (AMOX+systemic metronidazole (MET; 3 SURG+local tetracycline (TET; 4 SURG; 5 AMOX+MET+TET; 6 AMOX+MET; 7 TET; and 8 SURG+AMOX+MET+TET. Antibiotics were given immediately after SRP. Plaque, gingival redness, bleeding on probing, suppuration, PD, and CAL were recorded at baseline and after 3, 6, 12, 18, and 24 months. Treatment effects were evaluated by linear multilevel regression and logistic multilevel regression models. We considered only data from sites with a baseline PD of at least 5 mm of 187 patients completing the study. Results: Surgically treated patients experienced most CAL loss. Adjunctive therapy including SURG was most effective in reducing PD. Combining SURG with AMOX, MET, and TET gave significant clinical benefits. Past and current smoking habits were significant predictors of deeper PD. Only current smoking was a significant predictor of CAL loss. Bleeding, accumulation of plaque, gingival redness, and suppuration were significant predictors of further CAL loss and deeper PD. Conclusions: Both surgical and non-surgical therapies can be used to arrest chronic periodontitis. SURG+AMOX+MET+TET gave best maintenance of clinical results.

Dependence between sea surge, river flow and precipitation in south and west Britain

Directory of Open Access Journals (Sweden)

C. Svensson

2004-01-01

Full Text Available Estuaries around Great Britain may be at heightened risk of flooding because of the simultaneous occurrence of extreme sea surge and river flow, both of which may be caused by mid-latitude cyclones. A measure especially suited for extremes was employed to estimate dependence between river flow and sea surge. To assist in the interpretation of why flow-surge dependence occurs in some areas and not in others, the dependence between precipitation and surge and between precipitation and river flow was also studied. Case studies of the meteorological situations leading to high surges and/or river flows were also carried out. The present study concerns catchments draining to the south and west coasts of Great Britain. Statistically significant dependence between river flow and daily maximum sea surge may be found at catchments spread along most of this coastline. However, higher dependence is generally found in catchments in hilly areas with a southerly to westerly aspect. Here, precipitation in south-westerly airflow, which is generally the quadrant of prevailing winds, will be enhanced orographically as the first higher ground is encountered. The sloping catchments may respond quickly to the abundant rainfall and the flow peak may arrive in the estuary on the same day as a large sea surge is produced by the winds and low atmospheric pressure associated with the cyclone. There are three regions where flow-surge dependence is strong: the western part of the English south coast, southern Wales and around the Solway Firth. To reduce the influence of tide-surge interaction on the dependence analysis, the dependence between river flow and daily maximum surge occurring at high tide was estimated. The general pattern of areas with higher dependence is similar to that using the daily maximum surge. The dependence between river flow and daily maximum sea surge is often strongest when surge and flow occur on the same day. The west coast from Wales and

The Emerging Role of PD-1/PD-L1-Targeting Immunotherapy in the Treatment of Metastatic Urothelial Carcinoma.

Science.gov (United States)

Gwynn, Morgan E; DeRemer, David L

2018-01-01

To summarize and evaluate immunotherapy agents targeting programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) recently approved for the treatment of metastatic urothelial carcinomas (UC). A literature review was performed using PubMed (2012 to June 2017), the American Society of Clinical Oncology abstract databases (2012 to June 2017 Annual Meetings/symposia), and the America Association for Cancer Research symposia (2012 to June 2017). A search using clinicaltrials.gov was conducted to identify studies for atezolizumab, avelumab, durvalumab, nivolumab, and pembrolizumab. English language phase I to III studies assessing PD-1 and PD-L1 in UC were incorporated. Atezolizumab, avelumab, durvalumab, nivolumab, and pembrolizumab have demonstrated clinical efficacy with tolerable toxicities in patients with metastatic UC with disease progression following platinum-based chemotherapy. Anti-PD-1/PD-L1 therapies may provide overall survival advantage; these are currently being evaluated in ongoing phase 3 studies. Greater objective response rates seem to be observed in PD-L1-positive patients versus PD-L1-negative patients, but methodologies in this assessment differ among clinical trials. The identification of biomarkers that provide greater insight into patients who positively respond to PD-1/PD-L1 therapies are needed. Treatment options for metastatic UC have expanded to include PD-1/PD-L1 therapies. These agents should be strongly considered as second-line therapy over single-agent chemotherapy for patients who fail or progress after platinum-based treatment.

Coastal Storm Surge Analysis: Storm Surge Results. Report 5: Intermediate Submission No. 3

Science.gov (United States)

2013-11-01

Vickery, P., D. Wadhera, A. Cox, V. Cardone , J. Hanson, and B. Blanton. 2012. Coastal storm surge analysis: Storm forcing (Intermediate Submission No...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jeffrey L. Hanson, Michael F. Forte, Brian Blanton

Vulnerability assessment of storm surges in the coastal area of Guangdong Province

Directory of Open Access Journals (Sweden)

K. Li

2011-07-01

Full Text Available Being bordered by the South China Sea and with long coastline, the coastal zone of Guangdong Province is often under severe risk of storm surges, as one of a few regions in China which is seriously threatened by storm surges. This article systematically analyzes the vulnerability factors of storm surges in the coastal area of Guangdong (from Yangjing to Shanwei. Five vulnerability assessment indicators of hazard-bearing bodies are proposed, which are social economic index, land use index, eco-environmental index, coastal construction index, and disaster-bearing capability index. Then storm surge vulnerability assessment index system in the coastal area of Guangdong is established. Additionally, the international general mode about coastal vulnerability assessment is improved, and the vulnerability evolution model of storm surges in the coastal area of Guangdong is constructed. Using ArcGIS, the vulnerability zoning map of storm surges in the study region is drawn. Results show that there is the highest degree of storm surge vulnerability in Zhuhai, Panyu, and Taishan; second in Zhongshan, Dongguan, Huiyang, and Haifeng; third in Jiangmen, Shanwei, Yangjiang, and Yangdong; fourth in Baoan, Kaiping, and Enping; and lowest in Guangzhou, Shunde, Shenzhen, and Longgang. This study on the risk of storm surges in these coastal cities can guide the land use of coastal cities in the future, and provide scientific advice for the government to prevent and mitigate the storm surge disasters. It has important theoretical and practical significance.

Exercising Tactically for Taming Postmeal Glucose Surges

Directory of Open Access Journals (Sweden)

Elsamma Chacko

2016-01-01

Full Text Available This review seeks to synthesize data on the timing, intensity, and duration of exercise found scattered over some 39 studies spanning 3+ decades into optimal exercise conditions for controlling postmeal glucose surges. The results show that a light aerobic exercise for 60 min or moderate activity for 20–30 min starting 30 min after meal can efficiently blunt the glucose surge, with minimal risk of hypoglycemia. Exercising at other times could lead to glucose elevation caused by counterregulation. Adding a short bout of resistance exercise of moderate intensity (60%–80%  VO2max to the aerobic activity, 2 or 3 times a week as recommended by the current guidelines, may also help with the lowering of glucose surges. On the other hand, high-intensity exercise (>80%  VO2max causes wide glucose fluctuations and its feasibility and efficacy for glucose regulation remain to be ascertained. Promoting the kind of physical activity that best counters postmeal hyperglycemia is crucial because hundreds of millions of diabetes patients living in developing countries and in the pockets of poverty in the West must do without medicines, supplies, and special diets. Physical activity is the one tool they may readily utilize to tame postmeal glucose surges. Exercising in this manner does not violate any of the current guidelines, which encourage exercise any time.

Exercising Tactically for Taming Postmeal Glucose Surges.

Science.gov (United States)

Chacko, Elsamma

2016-01-01

This review seeks to synthesize data on the timing, intensity, and duration of exercise found scattered over some 39 studies spanning 3+ decades into optimal exercise conditions for controlling postmeal glucose surges. The results show that a light aerobic exercise for 60 min or moderate activity for 20-30 min starting 30 min after meal can efficiently blunt the glucose surge, with minimal risk of hypoglycemia. Exercising at other times could lead to glucose elevation caused by counterregulation. Adding a short bout of resistance exercise of moderate intensity (60%-80%  VO2max) to the aerobic activity, 2 or 3 times a week as recommended by the current guidelines, may also help with the lowering of glucose surges. On the other hand, high-intensity exercise (>80%  VO2max) causes wide glucose fluctuations and its feasibility and efficacy for glucose regulation remain to be ascertained. Promoting the kind of physical activity that best counters postmeal hyperglycemia is crucial because hundreds of millions of diabetes patients living in developing countries and in the pockets of poverty in the West must do without medicines, supplies, and special diets. Physical activity is the one tool they may readily utilize to tame postmeal glucose surges. Exercising in this manner does not violate any of the current guidelines, which encourage exercise any time.

Programmed Death Ligand 1 (PD-L1 Tumor Expression Is Associated with a Better Prognosis and Diabetic Disease in Triple Negative Breast Cancer Patients

Directory of Open Access Journals (Sweden)

Gerardo Botti

2017-02-01

Full Text Available Triple Negative Breast Cancers (TNBC subtype is an aggressive disease with poor clinical outcome. The only treatment available is surgery followed by chemotherapy or radiotherapy. Programmed death-ligand 1 (PD-L1 is a trans-membrane protein expressed on a wide variety of cells including immune cells, epithelial and vascular endothelial cells. Recently, PD-1/PD-L1 pathway signaling was described as an adaptive immune resistance mechanism enacted by the tumor cells to evade the immune response. Its presence on tumor cell membranes, acquired for this reason, through time, is an important prognostic value. However, data available in the literature about PD-L1 immunohistochemical expression in breast cancer are often discordant and not uniform, probably for the use of different antibodies clones and the high molecular heterogeneity of the different tumor types. The absence of target therapies, in particular for TNBC, has shifted the clinical attention mainly on the role of PD-L1 in this subtype of breast cancer. In this study, we evaluated tumor and TIL (tumor infiltrating lymphocytes PDL-1 expression in a series of TNBC, included in Tissue Micro Arrays (TMAs, to define its real prognostic value, optimizing immunohistochemistry method with an “approved for diagnostic assay” antibody. PD-L1 expression directly correlated with proliferation index (Ki-67, glycemia, the presence of diabetes and indirectly with menopausal status, presence of lymph node metastasis and relapse. The analysis of Kaplan–Meier showed that an increased PD-L1 expression was strongly associated with better disease-free survival (DFS but not correlated with overall survival (OS. Our data confirmed that PD-L1 could be an important marker for prognostic stratification and for planning immune checkpoint inhibitors therapies in patients with TNBC.

Methodology for surge pressure evaluation in a water injection system

Energy Technology Data Exchange (ETDEWEB)

Meliande, Patricia; Nascimento, Elson A. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Dept. de Engenharia Civil; Mascarenhas, Flavio C.B. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Hidraulica Computacional; Dandoulakis, Joao P. [SHELL of Brazil, Rio de Janeiro, RJ (Brazil)

2009-07-01

Predicting transient effects, known as surge pressures, is of high importance for offshore industry. It involves detailed computer modeling that attempts to simulate the complex interaction between flow line and fluid in order to ensure efficient system integrity. Platform process operators normally raise concerns whether the water injection system is adequately designed or not to be protected against possible surge pressures during sudden valve closure. This report aims to evaluate the surge pressures in Bijupira and Salema water injection systems due to valve closure, through a computer model simulation. Comparisons among the results from empirical formulations are discussed and supplementary analysis for Salema system were performed in order to define the maximum volumetric flow rate for which the design pressure was able to withstand. Maximum surge pressure values of 287.76 bar and 318.58 bar, obtained in Salema and Bijupira respectively, using empirical formulations have surpassed the operating pressure design, while the computer model results have pointed the greatest surge pressure value of 282 bar in Salema system. (author)

Developing models for patient flow and daily surge capacity research.

Science.gov (United States)

Asplin, Brent R; Flottemesch, Thomas J; Gordon, Bradley D

2006-11-01

Between 1993 and 2003, visits to U.S. emergency departments (EDs) increased by 26%, to a total of 114 million visits annually. At the same time, the number of U.S. EDs decreased by more than 400, and almost 200,000 inpatient hospital beds were taken out of service. In this context, the adequacy of daily surge capacity within the system is clearly an important issue. However, the research agenda on surge capacity thus far has focused primarily on large-scale disasters, such as pandemic influenza or a serious bioterrorism event. The concept of daily surge capacity and its relationship to the broader research agenda on patient flow is a relatively new area of investigation. In this article, the authors begin by describing the overlap between the research agendas on daily surge capacity and patient flow. Next, they propose two models that have potential applications for both daily surge capacity and hospitalwide patient-flow research. Finally, they identify potential research questions that are based on applications of the proposed research models.

Strategic Engagement of Technical Surge Capacity for Intensified Polio Eradication Initiative in Nigeria, 2012-2015.

Science.gov (United States)

Yehualashet, Yared G; Mkanda, Pascal; Gasasira, Alex; Erbeto, Tesfaye; Onimisi, Anthony; Horton, Janet; Banda, Richard; Tegegn, Sisay G; Ahmed, Haruna; Afolabi, Oluwole; Wadda, Alieu; Vaz, Rui G; Nsubuga, Peter

2016-05-01

; supporting other public health emergencies, such as the Ebola outbreak response and measles and meningitis outbreaks; and strengthening the integrated disease surveillance and response. Due to weak health systems in the country, it is vital to maintain a reasonable level of the surge capacity for successful implementation of the 2013-2018 global polio endgame strategy and beyond. © 2016 World Health Organization; licensee Oxford Journals.

Surge of plasma waves in an inhomogeneous plasma

International Nuclear Information System (INIS)

Benhassine, Mohammed

1985-01-01

The first part of this research thesis addresses the propagation of waves in a plasma. It presents the equation of propagation of an electromagnetic wave in a plasma without magnetic field, and analyses the propagation in an inhomogeneous medium. The second part addresses the wave-particle interaction: interaction between electrons and an electromagnetic wave, between electrons and an electrostatic wave (trapping), and between electrons and a localised electric field. The third chapter presents the analytic theory of oscillations of a cold plasma (macroscopic equations in Lagrangian coordinates, analytic solution before surge). The next chapter discusses physical interpretations before the wave surge, after the wave surge, and about energy exchange (within or outside of resonance). Numerical simulations and their results are then reported and discussed. The sixth chapter addresses the case of an electrostatic wave surge in a hot plasma. It notably addresses the following aspects: equivalence between the description of moments and the Waterbag model, interaction between non linearity and thermal effects, variation of electric field amplitude with temperature. Results of numerical simulations are presented, and the last part addresses experimental predictions for microwaves-plasma interaction and laser-matter interaction [fr

Tide-surge Interaction Intensified by the Taiwan Strait

Science.gov (United States)

Zhang, Wen-Zhou; Shi, Fengyan; Hong, Hua-Sheng; Shang, Shao-Ping; Kirby, James T.

2010-06-01

The Taiwan Strait is a long and wide shelf-channel where the hydrodynamics is extremely complex, being characterized by strong tides, and where storm surges frequently occur during the typhoon season. Obvious oscillations due to tide-surge interaction were observed by tide gauges along the northern Fujian coast, the west bank of the Taiwan Strait, during Typhoon Dan (1999). Numerical experiments indicate that nonlinear bottom friction (described by the quadratic formula) is a major factor to predict these oscillations while the nonlinear advective terms and the shallow water effect have little contribution. It is found that the tide-surge interaction in the northern portion of the Taiwan Strait is intensified by the strait. Simulations based on simplified topographies with and without the island of Taiwan show that, in the presence of the island, the channel effect strengthens tidal currents and tends to align the major axes of tidal ellipses along the channel direction. Storm-induced currents are also strengthened by the channel. The pattern of strong tidal currents and storm-induced currents along the channel direction enhances tide-surge interaction via the nonlinear bottom friction, resulting in the obvious oscillations along the northern Fujian coast.

The Xylella fastidiosa PD1063 protein is secreted in association with outer membrane vesicles.

Science.gov (United States)

Pierce, Brittany K; Voegel, Tanja; Kirkpatrick, Bruce C

2014-01-01

Xylella fastidiosa is a gram-negative, xylem-limited plant pathogenic bacterium that causes disease in a variety of economically important agricultural crops including Pierce's disease of grapevines. Xylella fastidiosa biofilms formed in the xylem vessels of plants play a key role in early colonization and pathogenicity by providing a protected niche and enhanced cell survival. Here we investigate the role of Xylella fastidiosa PD1063, the predicted ortholog of Xanthomonas oryzae pv. oryzae PXO_03968, which encodes an outer membrane protein. To assess the function of the Xylella fastidiosa ortholog, we created Xylella fastidiosa mutants deleted for PD1063 and then assessed biofilm formation, cell-cell aggregation and cell growth in vitro. We also assessed disease severity and pathogen titers in grapevines mechanically inoculated with the Xylella fastidiosa PD1063 mutant. We found a significant decrease in cell-cell aggregation among PD1063 mutants but no differences in cell growth, biofilm formation, disease severity or titers in planta. Based on the demonstration that Xanthomonas oryzae pv. oryzae PXO_03968 encodes an outer membrane protein, secreted in association with outer membrane vesicles, we predicted that PD1063 would also be secreted in a similar manner. Using anti-PD1063 antibodies, we found PD1063 in the supernatant and secreted in association with outer membrane vesicles. PD1063 purified from the supernatant, outer membrane fractions and outer membrane vesicles was 19.2 kD, corresponding to the predicted size of the processed protein. Our findings suggest Xylella fastidiosa PD1063 is not essential for development of Pierce's disease in Vitis vinifera grapevines although further research is required to determine the function of the PD1063 outer membrane protein in Xylella fastidiosa.

Adaptive mesh refinement for storm surge

KAUST Repository

Mandli, Kyle T.; Dawson, Clint N.

2014-01-01

An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the GeoClaw framework and compared to ADCIRC for Hurricane Ike along with observed tide gauge data and the computational cost of each model run. © 2014 Elsevier Ltd.

Adaptive mesh refinement for storm surge

KAUST Repository

Mandli, Kyle T.

2014-03-01

An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the GeoClaw framework and compared to ADCIRC for Hurricane Ike along with observed tide gauge data and the computational cost of each model run. © 2014 Elsevier Ltd.

Structure design of water discharge surge tank of nuclear power plant

International Nuclear Information System (INIS)

Wang Fang; Hou Shuqiang

2015-01-01

Drainage is an important function of water discharge surge tank in nuclear power plant. There is little wall and beam inside the water discharge surge tank due to the requirement of major work, which is different from the general structure. Taking water discharge surge tank of nuclear power plant for example, concerned problems are expatiated in the structure scheme of water discharge surge tank, and important structural components are analyzed. Structural analysis model is established by ANSYS finite element analysis. A comprehensive and numerical analysis is performed for different combinations of structural model, and the internal force of structure is extracted. Finally, suggestions for design of similar structure are proposed. (authors)

Storm surge evolution and its relationship to climate oscillations at Duck, NC

Science.gov (United States)

Munroe, Robert; Curtis, Scott

2017-07-01

Coastal communities experience increased vulnerability during storm surge events through the risk of damage to coastal infrastructure, erosion/deposition, and the endangerment of human life. Policy and planning measures attempt to avoid or mitigate storm surge consequences through building codes and setbacks, beach stabilization, insurance rates, and coastal zoning. The coastal emergency management community and public react and respond on shorter time scales, through temporary protection, emergency stockpiling, and evacuation. This study utilizes time series analysis, the Kolmogorov-Smirnov (K-S) test, Pearson's correlation, and the generalized extreme value (GEV) theorem to make the connection between climate oscillation indices and storm surge characteristics intra-seasonally to inter-annually. Results indicate that an El Niño (+ENSO), negative phase of the NAO, and positive phase of the PNA pattern all support longer duration and hence more powerful surge events, especially in winter. Increased surge duration increases the likelihood of extensive erosion, inland inundation, among other undesirable effects of the surge hazard.

Unplanned Start on Peritoneal Dialysis Right after PD Catheter Implantation for Older People with End-Stage Renal Disease.

Science.gov (United States)

Povlsen, Johan V; Sørensen, Anette Bagger; Ivarsen, Per

2015-11-01

Unplanned start on dialysis remains a major problem for the dialysis community worldwide. Late-referred patients with end-stage renal disease (ESRD) and urgent need for dialysis are overrepresented among older people. These patients are particularly likely to be started on in-center hemodialysis (HD), with a temporary vascular access known to be associated with excess mortality and increased risks of potentially lethal complications such as bacteremia and central venous thrombosis or stenosis.The present paper describes in detail our program for unplanned start on automated peritoneal dialysis (APD) right after PD catheter implantation and summarizes our experiences with the program so far. Compared with planned start on PD after at least 2 weeks of break-in between PD catheter implantation and initiation of dialysis, unplanned start may be associated with a slight increased risk of mechanical complications but apparently no detrimental effect on mortality, peritonitis-free survival, or PD technique survival.In our opinion and experience, the risk of serious complications associated with the implantation and immediate use of a PD catheter is less than the risk of complications associated with unplanned start on HD with a temporary central venous catheter (CVC). Unplanned start on APD is a gentle, safe, and feasible alternative to unplanned start on HD with a temporary CVC that is also valid for the late-referred older patient with ESRD and urgent need for dialysis. Copyright © 2015 International Society for Peritoneal Dialysis.

Comparison of two recent storm surge events based on results of field surveys

Science.gov (United States)

Nakamura, Ryota; Shibayama, Tomoya; Mikami, Takahito; Esteban, Miguel; Takagi, Hiroshi; Maell, Martin; Iwamoto, Takumu

2017-10-01

This paper compares two different types of storm surge disaster based on field surveys. Two cases: a severe storm surge flood with its height of over 5 m due to Typhoon Haiyan (2013) in Philippine, and inundation of storm surge around Nemuro city in Hokkaido of Japan with its maximum surge height of 2.8 m caused by extra-tropical cyclone are taken as examples. For the case of the Typhoon Haiyan, buildings located in coastal region were severely affected due to a rapidly increase in ocean surface. The non-engineering buildings were partially or completely destroyed due to their debris transported to an inner bay region. In fact, several previous reports indicated two unique features, bore-like wave and remarkably high speed currents. These characteristics of the storm surge may contribute to a wide-spread corruption for the buildings around the affected region. Furthermore, in the region where the surge height was nearly 3 m, the wooden houses were completely or partially destroyed. On the other hand, in Nemuro city, a degree of suffering in human and facility caused by the storm surge is minor. There was almost no partially destroyed residential houses even though the height of storm surge reached nearly 2.8 m. An observation in the tide station in Nemuro indicated that this was a usual type of storm surge, which showed a gradual increase of sea level height in several hours without possessing the unique characteristics like Typhoon Haiyan. As a result, not only the height of storm surge but also the robustness of the buildings and characteristics of storm surge, such as bore like wave and strong currents, determined the existent of devastation in coastal regions.

Determining Storm Surge Return Periods: The Use of Evidence of Historic Events

DEFF Research Database (Denmark)

Madsen, Kristine S.; Sørensen, Carlo Sass; Schmith, Torben

Storm surges are a major concern for many coastal communities, and rising levels of surges is a key concern in relation to climate change. The sea level of a statistical 100-year or 1000-year storm surge event and similar statistical measures are used for spatial planning and emergency preparedness...

Tide-surge interaction along the east coast of the Leizhou Peninsula, South China Sea

Science.gov (United States)

Zhang, Heng; Cheng, Weicong; Qiu, Xixi; Feng, Xiangbo; Gong, Wenping

2017-06-01

A triply-nested two-dimensional (2D) ocean circulation model along with observed sea level records are used to study tide-surge interaction along the east coast of the Leizhou Peninsula (LP) which is characterized by extensive mudflats, large tidal ranges and a complex coastline. The dependency of surge maxima on the water level and the phase of tide are respectively investigated using two statistical approaches. Results show that tide-surge interaction along the east coast of the LP is significant, where surges peak 3-6 h before or after the nearest high water. The triply-nested 2D ocean circulation model is used to quantify tide-surge interaction in this region and to investigate its physical cause. The largest amplitudes of tide-surge interaction are found in the shallow water region of the Leizhou Bay, with values up to 1 m during typhoon events. Numerical experiments reveal that nonlinear bottom friction is the main contributor to tide-surge interaction, while the contribution of the nonlinear advective effect can be neglected. The shallow water effect enhances the role of nonlinear bottom friction in determining tide-surge modulation, leaving the surge peaks usually occur on the rising or falling tide. It is also found that the relative contribution of local wind and remote wind is different depending on the storm track and storm intensity, which would finally affect the temporal and spatial distribution of tide-surge interaction during typhoon events. These findings confirm the importance of coupling storm surges and tides for the prediction of storm surge events in regions which are characterized by shallow water depths and large tidal ranges.

Surge protective device response to steep front transient in low voltage circuit

Energy Technology Data Exchange (ETDEWEB)

Marcuz, J.; Binczak, S.; Bilbault, J.M. [Universite de Bourgogne, Dijon (France)], Emails: jerome.marcuz@ laposte.net, stbinc@u-bourgogne.fr, bilbault@u-bourgogne.fr; Girard, F. [ADEE Electronic, Pont de Pany (France)

2007-07-01

Surge propagation on cables of electrical or data lines leads to a major protection problem as the number of equipment based on solid-state circuits or microprocessors increases. Sub-microsecond components of real surge waveform has to be taken into account for a proper protection even in the case of surges caused by indirect lightning effects. The response of a model of transient voltage suppressor diode based surge protection device (SPD) to fast front transient is analytically studied, then compared to simulations, including the lines connected to the SPD and to the protected equipment. (author)

Distribution of auroral surges in the evening sector

International Nuclear Information System (INIS)

Kidd, S.R.; Rostoker, G.

1991-01-01

Over the past dacades a large statistical data base has been gathered consisting of both ground-based magnetometer and all-sky camera records from which researchers have inferred the distribution of substorm expansive phase events across the nighttime sector. Almost without exception, the activity distribution has been based on single station data acquired over periods of years. However, to truly establish the occurrence frequency of substorm expansive phase events, it is necessary to view the entire nighttime sector instantaneously in the light of evidence which shows that more than one expansive phase disturbance can be in progress across the broad expanse of the evening sector. In this paper, the authors study the distribution of regions of localized auroral luminosity in the poleward portion of the evening sectorauroral oval using images in the ultraviolet portion of the auroral spectrum acquired by the Viking satellite over 9 months in 1986. They find that auroral surge activity peaks in the hour before local magnetic midnight, with the probability of detecting a surge steadily decreasing to 10% of the probability of finding a surge in the hour prior to midnight as one moves westward towards 1,900 MLT. They show that their conclusion is not dependent on the threshold chosen for surge identification over a reasonable portion of the intensity range covered by the Viking imager. They further show that for the interval of several months near sunspot minimum in 1986 there is better than a 90% chance that no surge will be detected in a 1-hour range of magnetic local time if one were to sample that segment of the auroral oval at any arbitrary time

Monitoring Inland Storm Surge and Flooding from Hurricane Rita

Science.gov (United States)

McGee, Benton D.; Tollett, Roland W.; Mason, Jr., Robert R.

2006-01-01

Pressure transducers (sensors) and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network of sensors was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations, and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast.

Probabilistic hurricane-induced storm surge hazard assessment in Guadeloupe, Lesser Antilles

Science.gov (United States)

Krien, Y.; Dudon, B.; Roger, J.; Zahibo, N.

2015-08-01

Current storm surge hazard maps in the French West Indies are essentially based on simple statistical methods using limited historical data and early low-resolution models which do not take the effect of waves into account. In this paper, we infer new 100-year and 1000-year surge levels in Guadeloupe from the numerical modelling of storm surges induced by a large set of synthetic events that are in statistical agreement with features of historical hurricanes in the North Atlantic Basin between 1980 and 2011. Computations are performed using the wave-current coupled model ADCIRC-SWAN with high grid resolutions (up to 40-60 m) in the coastal and wave dissipation areas. This model is validated against observations during past events such as hurricane HUGO (1989). Results are generally found to be in reasonable agreement with past studies in areas where surge is essentially wind-driven, but found to differ significantly in coastal regions where the transfer of momentum from waves to the water column constitutes a non-negligible part of the total surge. The methodology, which can be applied to other islands in the Lesser Antilles, allows storm surge level maps to be obtained that can be of major interest for coastal planners and decision makers in terms of risk management.

Developing an early warning system for storm surge inundation in the Philippines

Science.gov (United States)

Tablazon, J.; Caro, C. V.; Lagmay, A. M. F.; Briones, J. B. L.; Dasallas, L.; Lapidez, J. P.; Santiago, J.; Suarez, J. K.; Ladiero, C.; Gonzalo, L. A.; Mungcal, M. T. F.; Malano, V.

2014-10-01

A storm surge is the sudden rise of sea water generated by an approaching storm, over and above the astronomical tides. This event imposes a major threat in the Philippine coastal areas, as manifested by Typhoon Haiyan on 8 November 2013 where more than 6000 people lost their lives. It has become evident that the need to develop an early warning system for storm surges is of utmost importance. To provide forecasts of the possible storm surge heights of an approaching typhoon, the Nationwide Operational Assessment of Hazards under the Department of Science and Technology (DOST-Project NOAH) simulated historical tropical cyclones that entered the Philippine Area of Responsibility. Bathymetric data, storm track, central atmospheric pressure, and maximum wind speed were used as parameters for the Japan Meteorological Agency Storm Surge Model. The researchers calculated the frequency distribution of maximum storm surge heights of all typhoons under a specific Public Storm Warning Signal (PSWS) that passed through a particular coastal area. This determines the storm surge height corresponding to a given probability of occurrence. The storm surge heights from the model were added to the maximum astronomical tide data from WXTide software. The team then created maps of probable area inundation and flood levels of storm surges along coastal areas for a specific PSWS using the results of the frequency distribution. These maps were developed from the time series data of the storm tide at 10 min intervals of all observation points in the Philippines. This information will be beneficial in developing early warnings systems, static maps, disaster mitigation and preparedness plans, vulnerability assessments, risk-sensitive land use plans, shoreline defense efforts, and coastal protection measures. Moreover, these will support the local government units' mandate to raise public awareness, disseminate information about storm surge hazards, and implement appropriate counter

Strategic Engagement of Technical Surge Capacity for Intensified Polio Eradication Initiative in Nigeria, 2012–2015

Science.gov (United States)

Yehualashet, Yared G.; Mkanda, Pascal; Gasasira, Alex; Erbeto, Tesfaye; Onimisi, Anthony; Horton, Janet; Banda, Richard; Tegegn, Sisay G.; Ahmed, Haruna; Afolabi, Oluwole; Wadda, Alieu; Vaz, Rui G.; Nsubuga, Peter

2016-01-01

also been instrumental in building local capacity; supporting other public health emergencies, such as the Ebola outbreak response and measles and meningitis outbreaks; and strengthening the integrated disease surveillance and response. Due to weak health systems in the country, it is vital to maintain a reasonable level of the surge capacity for successful implementation of the 2013–2018 global polio endgame strategy and beyond. PMID:26912379

Fusion of 110Pd with 110Pd

International Nuclear Information System (INIS)

Morawek, W.

1991-07-01

In the framework of this thesis the excitation functions of the systems 110 Pd + 110 Pd and 110 Pd + 104 Ru could be measured. The evaporation-residual-nucleus cross sections is deviating from lighter systems dominated by channels, which arise from evaporation of α particles. In the reaction 110 Pd + 110 Pd no xn channels were observed. In comparison to other reactions qualitatively a strong fusion hindrance of this system is shown. (orig./HSI) [de

Color Discrimination in Patients with Gaucher Disease and Parkinson Disease.

Science.gov (United States)

Simon-Tov, Shlomi; Dinur, Tama; Giladi, Nir; Bar-Shira, Anat; Zelis, Mayaan; Zimran, Ari; Elstein, Deborah

2015-01-01

Poor color discrimination among patients with Parkinson disease (PD) has long been recognized. It has been shown that carrying one or two mutations in the β-glucocerebrosidase gene (GBA) for the autosomal disease Gaucher disease (GD), as based initially on clinical evidence, is a genetic risk factor for early-onset PD. The purpose of this study was to assess color discrimination in patients with one or two GBA mutations relative to healthy controls to ascertain whether this function is affected when persons with GD or even one GBA mutation develop PD. The Farnsworth-Munsell 100 hue test (FMHT) was evaluated among patients with GD+PD compared to patients with GD only, obligate GBA carriers with and without PD, patients with PD only, and healthy controls. FMHT outcome include computer-generated TES (Total Error Score) and values recommended by Vingrys & King-Smith. Six groups of 10 persons were tested. Significant differences were seen for male GD+PD and for age in PD. The highest mean TES was in the PD only group, the lowest in the GD only group. There was a significant difference because of PD in groups with GD and GBA carriers. GD+PD means were between GD only and PD only mean scores. These findings confirm that PD impacts color discrimination, more in males with GD+PD but nonetheless, GD+PD patients (but not GBA carriers) had better scores than PD only patients.

Hurricane storm surge and amphibian communities in coastal wetlands of northwestern Florida

Science.gov (United States)

Gunzburger, M.S.; Hughes, W.B.; Barichivich, W.J.; Staiger, J.S.

2010-01-01

Isolated wetlands in the Southeastern United States are dynamic habitats subject to fluctuating environmental conditions. Wetlands located near marine environments are subject to alterations in water chemistry due to storm surge during hurricanes. The objective of our study was to evaluate the effect of storm surge overwash on wetland amphibian communities. Thirty-two wetlands in northwestern Florida were sampled over a 45-month period to assess amphibian species richness and water chemistry. During this study, seven wetlands were overwashed by storm surge from Hurricane Dennis which made landfall 10 July 2005 in the Florida panhandle. This event allowed us to evaluate the effect of storm surge overwash on water chemistry and amphibian communities of the wetlands. Specific conductance across all wetlands was low pre-storm (marine habitats are resistant to the effects of storm surge overwash. ?? 2010 Springer Science+Business Media B.V.

A simulation method for lightning surge response of switching power

International Nuclear Information System (INIS)

Wei, Ming; Chen, Xiang

2013-01-01

In order to meet the need of protection design for lighting surge, a prediction method of lightning electromagnetic pulse (LEMP) response which is based on system identification is presented. Experiments of switching power's surge injection were conducted, and the input and output data were sampled, de-noised and de-trended. In addition, the model of energy coupling transfer function was obtained by system identification method. Simulation results show that the system identification method can predict the surge response of linear circuit well. The method proposed in the paper provided a convenient and effective technology for simulation of lightning effect.

Electromagnetic computation methods for lightning surge protection studies

CERN Document Server

Baba, Yoshihiro

2016-01-01

This book is the first to consolidate current research and to examine the theories of electromagnetic computation methods in relation to lightning surge protection. The authors introduce and compare existing electromagnetic computation methods such as the method of moments (MOM), the partial element equivalent circuit (PEEC), the finite element method (FEM), the transmission-line modeling (TLM) method, and the finite-difference time-domain (FDTD) method. The application of FDTD method to lightning protection studies is a topic that has matured through many practical applications in the past decade, and the authors explain the derivation of Maxwell's equations required by the FDTD, and modeling of various electrical components needed in computing lightning electromagnetic fields and surges with the FDTD method. The book describes the application of FDTD method to current and emerging problems of lightning surge protection of continuously more complex installations, particularly in critical infrastructures of e...

Condition Assessment of Metal Oxide Surge Arrester Based on Multi-Layer SVM Classifier

Directory of Open Access Journals (Sweden)

M Khodsuz

2015-12-01

Full Text Available This paper introduces the indicators for surge arrester condition assessment based on the leakage current analysis. Maximum amplitude of fundamental harmonic of the resistive leakage current, maximum amplitude of third harmonic of the resistive leakage current and maximum amplitude of fundamental harmonic of the capacitive leakage current were used as indicators for surge arrester condition monitoring. Also, the effects of operating voltage fluctuation, third harmonic of voltage, overvoltage and surge arrester aging on these indicators were studied. Then, obtained data are applied to the multi-layer support vector machine for recognizing of surge arrester conditions. Obtained results show that introduced indicators have the high ability for evaluation of surge arrester conditions.

A numerical storm surge forecast model with Kalman filter

Institute of Scientific and Technical Information of China (English)

Yu Fujiang; Zhang Zhanhai; Lin Yihua

2001-01-01

Kalman filter data assimilation technique is incorporated into a standard two-dimensional linear storm surge model. Imperfect model equation and imperfect meteorological forcimg are accounted for by adding noise terms to the momentum equations. The deterministic model output is corrected by using the available tidal gauge station data. The stationary Kalman filter algorithm for the model domain is calculated by an iterative procedure using specified information on the inaccuracies in the momentum equations and specified error information for the observations. An application to a real storm surge that occurred in the summer of 1956 in the East China Sea is performed by means of this data assimilation technique. The result shows that Kalman filter is useful for storm surge forecast and hindcast.

Hospital-Based Coalition to Improve Regional Surge Capacity

Directory of Open Access Journals (Sweden)

James M. Learning

2012-12-01

Full Text Available Introduction: Surge capacity for optimization of access to hospital beds is a limiting factor in response to catastrophic events. Medical facilities, communication tools, manpower, and resource reserves exist to respond to these events. However, these factors may not be optimally functioning to generate an effective and efficient surge response. The objective was to improve the function of these factors.Methods: Regional healthcare facilities and supporting local emergency response agencies developed a coalition (the Healthcare Facilities Partnership of South Central Pennsylvania; HCFP¬SCPA to increase regional surge capacity and emergency preparedness for healthcare facilities. The coalition focused on 6 objectives: (1 increase awareness of capabilities and assets, (2 develop and pilot test advanced planning and exercising of plans in the region, (3 augment written medical mutual aid agreements, (4 develop and strengthen partnership relationships, (5 ensure National Incident Management System compliance, and (6 develop and test a plan for effective utilization of volunteer healthcare professionals.Results: In comparison to baseline measurements, the coalition improved existing areas covered under all 6 objectives documented during a 24-month evaluation period. Enhanced communications between the hospital coalition, and real-time exercises, were used to provide evidence of improved preparedness for putative mass casualty incidents.Conclusion: The HCFP-SCPA successfully increased preparedness and surge capacity through a partnership of regional healthcare facilities and emergency response agencies.

Aging assessment of surge protective devices in nuclear power plants

International Nuclear Information System (INIS)

Davis, J.F.; Subudhi, M.; Carroll, D.P.

1996-01-01

An assessment was performed to determine the effects of aging on the performance and availability of surge protective devices (SPDs), used in electrical power and control systems in nuclear power plants. Although SPDs have not been classified as safety-related, they are risk-important because they can minimize the initiating event frequencies associated with loss of offsite power and reactor trips. Conversely, their failure due to age might cause some of those initiating events, e.g., through short circuit failure modes, or by allowing deterioration of the safety-related component(s) they are protecting from overvoltages, perhaps preventing a reactor trip, from an open circuit failure mode. From the data evaluated during 1980--1994, it was found that failures of surge arresters and suppressers by short circuits were neither a significant risk nor safety concern, and there were no failures of surge suppressers preventing a reactor trip. Simulations, using the ElectroMagnetic Transients Program (EMTP) were performed to determine the adequacy of high voltage surge arresters

Effect of Hydraulic Accumulator on Pressure Surge of a Hydrostatic Transmission System

Science.gov (United States)

Kumar, Ajit; Das, Jayanta; Dasgupta, Kabir; Barnwal, Manish Kumar

2018-04-01

Hydraulic power system is generally used in off-road vehicles for power transmission such as Heavy Earth Moving Machineries (HEMM). Their energy efficiency and unsubstantial failure becomes an extensive subject of analysis. Various arrangements in the system are compassed along with the utilization of some appropriate components. Application of a hydraulic accumulator is one among them. Benefits of accumulator is its multi-purpose usages like energy saving and pressure surge damping. This paper deals with the control of pressure surges in the hydraulic system and energy saving from the surges by using accumulator. For this purpose, the simulation of the hydraulic system is done in MATLAB/SimulinkR environment and an external disturbance is introduced to generate the pressure surge. The surge absorptivity of the accumulator is studied for different sizes at different pre-charged conditions of the accumulator. The discharge characteristics of different sized accumulators are also analyzed in this paper. It is observed that the ability to absorb the surge and stabilize the system is high in the smaller capacity accumulator. However the energy delivery time of larger sized accumulator is high.

Using satellite altimetry and tide gauges for storm surge warning

DEFF Research Database (Denmark)

Andersen, O. B.; Cheng, Yongcun; Deng, X.

2014-01-01

of Australia. For both locations we have tried to investigate the possibilities and limitations of the use of satellite altimetry to capture high frequency signals (surges) using data from the past 20 years. The two regions are chosen to represent extra-tropical and tropical storm surge conditions. We have...

Coastal Storm Surge Analysis: Storm Forcing. Report 3. Intermediate Submission No. 1.3

Science.gov (United States)

2013-07-01

The storm surge study considers both tropical storms and extratropical cyclones for determination of return period storm surge elevations. The...Appendix B: Extratropical Cyclone Selection in Support of FEMA Region III Storm Surge Modeling...stations applied in the storm selection process. ............................................. 56  Table B2. Extratropical cyclones selected from the

Centrifugal Compressor Surge Margin Improved With Diffuser Hub Surface Air Injection

Science.gov (United States)

Skoch, Gary J.

2002-01-01

Aerodynamic stability is an important parameter in the design of compressors for aircraft gas turbine engines. Compression system instabilities can cause compressor surge, which may lead to the loss of an aircraft. As a result, engine designers include a margin of safety between the operating line of the engine and the stability limit line of the compressor. The margin of safety is typically referred to as "surge margin." Achieving the highest possible level of surge margin while meeting design point performance objectives is the goal of the compressor designer. However, performance goals often must be compromised in order to achieve adequate levels of surge margin. Techniques to improve surge margin will permit more aggressive compressor designs. Centrifugal compressor surge margin improvement was demonstrated at the NASA Glenn Research Center by injecting air into the vaned diffuser of a 4:1-pressure-ratio centrifugal compressor. Tests were performed using injector nozzles located on the diffuser hub surface of a vane-island diffuser in the vaneless region between the impeller trailing edge and the diffuser-vane leading edge. The nozzle flow path and discharge shape were designed to produce an air stream that remained tangent to the hub surface as it traveled into the diffuser passage. Injector nozzles were located near the leading edge of 23 of the 24 diffuser vanes. One passage did not contain an injector so that instrumentation located in that passage would be preserved. Several orientations of the injected stream relative to the diffuser vane leading edge were tested over a range of injected flow rates. Only steady flow (nonpulsed) air injection was tested. At 100 percent of the design speed, a 15-percent improvement in the baseline surge margin was achieved with a nozzle orientation that produced a jet that was bisected by the diffuser vane leading edge. Other orientations also improved the baseline surge margin. Tests were conducted at speeds below the

Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease.

Science.gov (United States)

Chen, Xiaoying; Farrokhi, Vahid; Singh, Pratap; Ocana, Mireia Fernandez; Patel, Jenil; Lin, Lih-Ling; Neubert, Hendrik; Brodfuehrer, Joanne

2018-01-01

Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic kidney diseases. In the development of monoclonal antibody (mAb) therapeutics, there is an increasing trend to use biomeasures combined with mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modeling to enable decision making in early discovery. With the aim of guiding preclinical efforts on designing an antibody with optimized properties, we developed a mechanistic site-of-action (SoA) PK/PD model for human application. This model incorporates experimental biomeasures, including concentration of soluble Fn14 (sFn14) in human plasma and membrane Fn14 (mFn14) in human kidney tissue, and turnover rate of human sFn14. Pulse-chase studies using stable isotope-labeled amino acids and mass spectrometry indicated the sFn14 half-life to be approximately 5 hours in healthy volunteers. The biomeasures (concentration, turnover) of sFn14 in plasma reveals a significant hurdle in designing an antibody against Fn14 with desired characteristics. The projected dose (>1 mg/kg/wk for 90% target coverage) derived from the human PK/PD model revealed potential high and frequent dosing requirements under certain conditions. The PK/PD model suggested a unique bell-shaped relationship between target coverage and antibody affinity for anti-Fn14 mAb, which could be applied to direct the antibody engineering towards an optimized affinity. This investigation highlighted potential applications, including assessment of PK/PD risks during early target validation, human dose prediction and drug candidate optimization.

Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.

Science.gov (United States)

Maekawa, Naoya; Konnai, Satoru; Okagawa, Tomohiro; Nishimori, Asami; Ikebuchi, Ryoyo; Izumi, Yusuke; Takagi, Satoshi; Kagawa, Yumiko; Nakajima, Chie; Suzuki, Yasuhiko; Kato, Yukinari; Murata, Shiro; Ohashi, Kazuhiko

2016-01-01

Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads researchers to investigate novel therapeutic modalities, including immunotherapy. Programmed death 1 (PD-1) is a costimulatory receptor with immunosuppressive function. When it binds its ligands, PD-ligand 1 (PD-L1) or PD-L2, PD-1 on T cells negatively regulates activating signals from the T cell receptor, resulting in the inhibition of the effector function of cytotoxic T lymphocytes. Aberrant PD-L1 expression has been reported in many human cancers and is considered an immune escape mechanism for cancers. In clinical trials, anti-PD-1 or anti-PD-L1 antibodies induced tumor regression for several malignancies, including advanced melanoma, non-small cell lung carcinoma, and renal cell carcinoma. In this study, to assess the potential of the PD-1/PD-L1 axis as a novel therapeutic target for canine cancer immunotherapy, immunohistochemical analysis of PD-L1 expression in various malignant cancers of dogs was performed. Here, we show that dog oral melanoma, osteosarcoma, hemangiosarcoma, mast cell tumor, mammary adenocarcinoma, and prostate adenocarcinoma expressed PD-L1, whereas some other types of cancer did not. In addition, PD-1 was highly expressed on tumor-infiltrating lymphocytes obtained from oral melanoma, showing that lymphocytes in this cancer type might have been functionally exhausted. These results strongly encourage the clinical application of PD-1/PD-L1 inhibitors as novel therapeutic agents against these cancers in dogs.

Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.

Directory of Open Access Journals (Sweden)

Naoya Maekawa

Full Text Available Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads researchers to investigate novel therapeutic modalities, including immunotherapy. Programmed death 1 (PD-1 is a costimulatory receptor with immunosuppressive function. When it binds its ligands, PD-ligand 1 (PD-L1 or PD-L2, PD-1 on T cells negatively regulates activating signals from the T cell receptor, resulting in the inhibition of the effector function of cytotoxic T lymphocytes. Aberrant PD-L1 expression has been reported in many human cancers and is considered an immune escape mechanism for cancers. In clinical trials, anti-PD-1 or anti-PD-L1 antibodies induced tumor regression for several malignancies, including advanced melanoma, non-small cell lung carcinoma, and renal cell carcinoma. In this study, to assess the potential of the PD-1/PD-L1 axis as a novel therapeutic target for canine cancer immunotherapy, immunohistochemical analysis of PD-L1 expression in various malignant cancers of dogs was performed. Here, we show that dog oral melanoma, osteosarcoma, hemangiosarcoma, mast cell tumor, mammary adenocarcinoma, and prostate adenocarcinoma expressed PD-L1, whereas some other types of cancer did not. In addition, PD-1 was highly expressed on tumor-infiltrating lymphocytes obtained from oral melanoma, showing that lymphocytes in this cancer type might have been functionally exhausted. These results strongly encourage the clinical application of PD-1/PD-L1 inhibitors as novel therapeutic agents against these cancers in dogs.

Experimental Study on Noise Characteristic of Centrifugal Compressor Surge

OpenAIRE

Yang, Qichao; Zhao, Yuanyang; SHU, Yue; LI, Xiaosa; LI, Liansheng

2016-01-01

The centrifugal air compressor test rig is was designed and established. The experimental study was carried out on the surge characteristics of centrifugal compressor including the pressure in the pipe and the noise characteristics under different rotation speed. The tested results showed that both the suction pressure and discharge pressure fluctuation increase under surge condition and the amplitude of discharge pressure fluctuation is significantly higher than that of suction pressure. In ...

A Basis Function Approach to Simulate Storm Surge Events for Coastal Flood Risk Assessment

Science.gov (United States)

Wu, Wenyan; Westra, Seth; Leonard, Michael

2017-04-01

Storm surge is a significant contributor to flooding in coastal and estuarine regions, especially when it coincides with other flood producing mechanisms, such as extreme rainfall. Therefore, storm surge has always been a research focus in coastal flood risk assessment. Often numerical models have been developed to understand storm surge events for risk assessment (Kumagai et al. 2016; Li et al. 2016; Zhang et al. 2016) (Bastidas et al. 2016; Bilskie et al. 2016; Dalledonne and Mayerle 2016; Haigh et al. 2014; Kodaira et al. 2016; Lapetina and Sheng 2015), and assess how these events may change or evolve in the future (Izuru et al. 2015; Oey and Chou 2016). However, numeric models often require a lot of input information and difficulties arise when there are not sufficient data available (Madsen et al. 2015). Alternative, statistical methods have been used to forecast storm surge based on historical data (Hashemi et al. 2016; Kim et al. 2016) or to examine the long term trend in the change of storm surge events, especially under climate change (Balaguru et al. 2016; Oh et al. 2016; Rueda et al. 2016). In these studies, often the peak of surge events is used, which result in the loss of dynamic information within a tidal cycle or surge event (i.e. a time series of storm surge values). In this study, we propose an alternative basis function (BF) based approach to examine the different attributes (e.g. peak and durations) of storm surge events using historical data. Two simple two-parameter BFs were used: the exponential function and the triangular function. High quality hourly storm surge record from 15 tide gauges around Australia were examined. It was found that there are significantly location and seasonal variability in the peak and duration of storm surge events, which provides additional insights in coastal flood risk. In addition, the simple form of these BFs allows fast simulation of storm surge events and minimises the complexity of joint probability

Effect of switching surges on ehv system design

Energy Technology Data Exchange (ETDEWEB)

Baril, G A; McGillis, D

1966-01-01

The presence of switching surges imposes certain conditions on the design of ehv system and certain resulting requirements in the basic components of these systems. At extra high voltage, it becomes both a practical as well as an economic necessity to limit the magnitude of switching surge overvoltages. This can be accomplished by the installation of suitable terminal equipment, and for the 735 kV system it was found necessary to install permanently connected shunt reactors on the transmission lines and to provide for the installation of closing resistors on the circuit breakers.

Parkinson's disease prevalence in Fabry disease: A survey study

Directory of Open Access Journals (Sweden)

Adina H. Wise

2018-03-01

Full Text Available Recent research has suggested a possible link between Parkinson's disease (PD and Fabry disease. To test this relationship, we administered a self-report and family history questionnaire to determine the prevalence of PD in Fabry disease patients and family members with likely pathogenic alpha-galactosidase A (GLA mutations. A total of 90 Fabry patients (77 from the online survey and 13 from the Icahn School of Medicine at Mount Sinai (ISMMS were included in the analysis. Two of the Fabry disease patients who completed the online survey were diagnosed with PD (2/90, 2.2%. Among probands older than 60, 8.3% (2/24 were diagnosed with PD. Using Kaplan Meier survival analysis, the age-specific risk of PD by age 70 was 11.1%. Family history was available on 72 Fabry families from the online study and 9 Fabry families from ISMMS. Among these 81 families, 6 (7.4% had one first degree relative who fit the criteria for a conservative diagnosis of PD. The results of this study suggest that there may be an increased risk of developing PD in individuals with GLA mutations, but these findings should be interpreted with caution given the limitations of the study design.

A Numerical Simulation of Extratropical Storm Surge and Hydrodynamic Response in the Bohai Sea

OpenAIRE

Ding, Yumei; Ding, Lei

2014-01-01

A hindcast of typical extratropical storm surge occurring in the Bohai Sea in October 2003 is performed using a three-dimensional (3D) Finite Volume Coastal Ocean Model (FVCOM). The storm surge model is forced by 10 m winds obtained from the Weather Research Forecasting (WRF) model simulation. It is shown that the simulated storm surge and tides agree well with the observations. The nonlinear interaction between the surge and astronomical tides, the spatial distribution of the max...

CO-induced Pd segregation and the effect of subsurface Pd on CO adsorption on CuPd surfaces

International Nuclear Information System (INIS)

Padama, A A B; Villaos, R A B; Albia, J R; Diño, W A; Nakanishi, H; Kasai, H

2017-01-01

We report results of our study on the adsorption of CO on CuPd surfaces with bulk stoichiometric and nonstoichiometric layers using density functional theory (DFT). We found that the presence of Pd atoms in the subsurface layer promotes the adsorption of CO. We also observed CO-induced Pd segregation on the CuPd surface and we attribute this to the strong CO–Pd interaction. Lastly, we showed that the adsorption of CO promotes Pd–Pd interaction as compared to the pristine surface which promotes strong Cu–Pd interaction. These results indicate that CO adsorption on CuPd surfaces can be tuned by taking advantage of the CO-induced segregation and by considering the role of subsurface Pd atoms. (paper)

Assessment of water pipes durability under pressure surge

Science.gov (United States)

Pham Ha, Hai; Minh, Lanh Pham Thi; Tang Van, Lam; Bulgakov, Boris; Bazhenova, Soafia

2017-10-01

Surge phenomenon occurs on the pipeline by the closing valve or pump suddenly lost power. Due to the complexity of the water hammer simulation, previous researches have only considered water hammer on the single pipe or calculation of some positions on water pipe network, it have not been analysis for all of pipe on the water distribution systems. Simulation of water hammer due to closing valve on water distribution system and the influence level of pressure surge is evaluated at the defects on pipe. Water hammer on water supply pipe network are simulated by Water HAMMER software academic version and the capacity of defects are calculated by SINTAP. SINTAP developed from Brite-Euram projects in Brussels-Belgium with the aim to develop a process for assessing the integrity of the structure for the European industry. Based on the principle of mechanical fault, indicating the size of defects in materials affect the load capacity of the product in the course of work, the process has proposed setting up the diagram to fatigue assessment defect (FAD). The methods are applied for water pipe networks of Lien Chieu district, Da Nang city, Viet Nam, the results show the affected area of wave pressure by closing the valve and thereby assess the greatest pressure surge effect to corroded pipe. The SINTAP standard and finite element mesh analysis at the defect during the occurrence of pressure surge which will accurately assess the bearing capacity of the old pipes. This is one of the bases to predict the leakage locations on the water distribution systems. Amount of water hammer when identified on the water supply networks are decreasing due to local losses at the nodes as well as the friction with pipe wall, so this paper adequately simulate water hammer phenomena applying for actual water distribution systems. The research verified that pipe wall with defect is damaged under the pressure surge value.

Characteristics and possibilities of software tool for metal-oxide surge arresters selection

Directory of Open Access Journals (Sweden)

Đorđević Dragan

2012-01-01

Full Text Available This paper presents a procedure for the selection of metal-oxide surge arresters based on the instructions given in the Siemens and ABB catalogues, respecting their differences and the characteristics and possibilities of the software tool. The software tool was developed during the preparation of a Master's thesis titled, 'Automation of Metal-Oxide Surge Arresters Selection'. An example is presented of the selection of metal-oxide surge arresters using the developed software tool.

Cardiometabolic factors and disease duration in patients with Parkinson's disease.

Science.gov (United States)

Cassani, Erica; Cereda, Emanuele; Barichella, Michela; Madio, Carmen; Cancello, Raffaella; Caccialanza, Riccardo; Zini, Michela; Cilia, Roberto; Pezzoli, Gianni

2013-01-01

Previous studies have reported that patients with Parkinson's disease (PD) have a favorable cardiometabolic risk profile. The aim of this study was to investigate the relationship between cardiometabolic risk factors and the duration of disease. One hundred and fifty patients with PD (56.7% men) were studied, measuring body mass index (BMI), waist circumference (WC), body fat percentage (BF%) by impedance, fasting glucose, serum lipids, and transaminases. In sex- and age-adjusted correlation models, duration of PD was inversely related to BMI (r = -0.20; P HDL) levels were positively correlated with disease duration (P HDL-cholesterol ratio was also inversely associated with duration of PD (P HDL levels and total HDL-cholesterol ratio were favorably associated with duration of PD. This factor may contribute to cardiometabolic protection in PD. The mechanisms underlying this association deserve further investigation. Copyright © 2013 Elsevier Inc. All rights reserved.

Adriatic storm surges and related cross-basin sea-level slope

Science.gov (United States)

Međugorac, Iva; Orlić, Mirko; Janeković, Ivica; Pasarić, Zoran; Pasarić, Miroslava

2018-05-01

Storm surges pose a severe threat to the northernmost cities of the Adriatic coast, with Venice being most prone to flooding. It has been noted that some flooding episodes cause significantly different effects along the eastern and western Adriatic coasts, with indications that the difference is related to cross-basin sea-level slope. The present study aims to determine specific atmospheric conditions under which the slope develops and to explore connection with increased sea level along the two coastlines. The analysis is based on sea-level time series recorded at Venice and Bakar over the 1984-2014 interval, from which 38 most intensive storm-surge episodes were selected, and their meteorological backgrounds (ERA-Interim) were studied. The obtained sea-level extremes were grouped into three categories according to their cross-basin sea-level slope: storm surges that slope strongly westward (W type), those that slope eastward (E type) and ordinary storm surges (O type). Results show that the slope is controlled by wind action only, specifically, by the wind component towards a particular coast and by the cross-basin shear of along-basin wind. Meteorological fields were used to force an oceanographic numerical model in order to confirm the empirically established connection between the atmospheric forcing and the slope. Finally, it has been found that the intensity of storm surges along a particular Adriatic coast is determined by an interplay of sea-level slopes in the along and cross-basin directions.

Nonlinear chaotic model for predicting storm surges

Directory of Open Access Journals (Sweden)

M. Siek

2010-09-01

Full Text Available This paper addresses the use of the methods of nonlinear dynamics and chaos theory for building a predictive chaotic model from time series. The chaotic model predictions are made by the adaptive local models based on the dynamical neighbors found in the reconstructed phase space of the observables. We implemented the univariate and multivariate chaotic models with direct and multi-steps prediction techniques and optimized these models using an exhaustive search method. The built models were tested for predicting storm surge dynamics for different stormy conditions in the North Sea, and are compared to neural network models. The results show that the chaotic models can generally provide reliable and accurate short-term storm surge predictions.

Influence of Surge on Extreme Roll Amplitudes

DEFF Research Database (Denmark)

Vidic-Perunovic, Jelena; Rognebakke, Olav; Pedersen, Preben Terndrup

2008-01-01

Interference of the wave-induced ship surge motion with roll dynamics has been studied. The surge motion has been included in a previously derived hydrodynamic roll prediction model in order to account for the ship speed variation due to the longitudinal incident wave pressure force. Depending...... balanced in order to determine the added thrust term that would represent actions to maintain speed The resulting forward speed variation affects the frequency of encounter and the parametric roll resonant condition is directly influenced by this speed variation. The analysis procedure is demonstrated...... for an example containership sailing mainly in head sea condition and higher sea states. Sensitivity of the results to the added thrust model and vertical motion calculation is discussed....

Using Satellite Altimetry to Calibrate the Simulation of Typhoon Seth Storm Surge off Southeast China

Directory of Open Access Journals (Sweden)

Xiaohui Li

2018-04-01

Full Text Available Satellite altimeters can capture storm surges generated by typhoons and tropical storms, if the satellite flies over at the right time. In this study, we show TOPEX/Poseidon altimeter-observed storm surge features off Southeast China on 10 October 1994 during Typhoon Seth. We then use a three-dimensional, barotropic, finite-volume community ocean model (FVCOM to simulate storm surges. An innovative aspect is that satellite data are used to calibrate the storm surge model to improve model performance, by adjusting model wind forcing fields (the National Center for Environment Prediction (NCEP reanalysis product in reference to the typhoon best-track data. The calibration reduces the along-track root-mean-square (RMS difference between model and altimetric data from 0.15 to 0.10 m. It also reduces the RMS temporal difference from 0.21 to 0.18 m between the model results and independent tide-gauge data at Xiamen. In particular, the calibrated model produces a peak storm surge of 1.01 m at 6:00 10 October 1994 at Xiamen, agreeing with tide-gauge data; while the peak storm surge with the NCEP forcing is 0.71 m only. We further show that the interaction between storm surges and astronomical tides contributes to the peak storm surge by 34% and that the storm surge propagates southwestward as a coastally-trapped Kelvin wave.

Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups.

Science.gov (United States)

Jin, Xue; Shi, Xiaoxia; Gao, Jintian; Xu, Tongbin; Yin, Kedong

2018-03-27

Storm surge has become an important factor restricting the economic and social development of China's coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM) model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation.

Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups

Science.gov (United States)

Shi, Xiaoxia; Xu, Tongbin; Yin, Kedong

2018-01-01

Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM) model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation. PMID:29584628

Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups

Directory of Open Access Journals (Sweden)

Xue Jin

2018-03-01

Full Text Available Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc., storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation.

Catastrophe loss modelling of storm-surge flood risk in eastern England.

Science.gov (United States)

Muir Wood, Robert; Drayton, Michael; Berger, Agnete; Burgess, Paul; Wright, Tom

2005-06-15

Probabilistic catastrophe loss modelling techniques, comprising a large stochastic set of potential storm-surge flood events, each assigned an annual rate of occurrence, have been employed for quantifying risk in the coastal flood plain of eastern England. Based on the tracks of the causative extratropical cyclones, historical storm-surge events are categorized into three classes, with distinct windfields and surge geographies. Extreme combinations of "tide with surge" are then generated for an extreme value distribution developed for each class. Fragility curves are used to determine the probability and magnitude of breaching relative to water levels and wave action for each section of sea defence. Based on the time-history of water levels in the surge, and the simulated configuration of breaching, flow is time-stepped through the defences and propagated into the flood plain using a 50 m horizontal-resolution digital elevation model. Based on the values and locations of the building stock in the flood plain, losses are calculated using vulnerability functions linking flood depth and flood velocity to measures of property loss. The outputs from this model for a UK insurance industry portfolio include "loss exceedence probabilities" as well as "average annualized losses", which can be employed for calculating coastal flood risk premiums in each postcode.

Comparative cardiac pathological changes of Atlantic salmon (Salmo salar L.) affected with heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD)

DEFF Research Database (Denmark)

Yousaf, Muhammad Naveed; Koppang, Erling Olaf; Skjødt, Karsten

2013-01-01

The heart is considered the powerhouse of the cardiovascular system. Heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD) are cardiac diseases of marine farmed Atlantic salmon (Salmo salar) which commonly affect the heart in addition to the skeletal...

Multidecadal Scale Detection Time for Potentially Increasing Atlantic Storm Surges in a Warming Climate

Science.gov (United States)

Lee, Benjamin Seiyon; Haran, Murali; Keller, Klaus

2017-10-01

Storm surges are key drivers of coastal flooding, which generate considerable risks. Strategies to manage these risks can hinge on the ability to (i) project the return periods of extreme storm surges and (ii) detect potential changes in their statistical properties. There are several lines of evidence linking rising global average temperatures and increasingly frequent extreme storm surges. This conclusion is, however, subject to considerable structural uncertainty. This leads to two main questions: What are projections under various plausible statistical models? How long would it take to distinguish among these plausible statistical models? We address these questions by analyzing observed and simulated storm surge data. We find that (1) there is a positive correlation between global mean temperature rise and increasing frequencies of extreme storm surges; (2) there is considerable uncertainty underlying the strength of this relationship; and (3) if the frequency of storm surges is increasing, this increase can be detected within a multidecadal timescale (≈20 years from now).

THE CHALLENGE OF PD PATIENTS: GLUCOSE AND GLUCOSE DEGRADATION PRODUCTS IN PD SOLUTION

Directory of Open Access Journals (Sweden)

Yong-Lim Kim

2012-06-01

Full Text Available The main osmotic agent found in the peritoneal dialysis (PD solution is glucose. It has been of a wide use for great crystalloid osmotic power at a low concentration, simple metabolism, and excellent safety. On the other hand, anywhere between 60 to 80% of the glucose in the PD solution is absorbed - a 100 to 300 mg of daily glucose absorption. Once into the systemic circulation, glucose can be a cause for metabolic complications including obesity. Indeed, the diabetiform change observed in the peritoneal membrane in the long-term PD patients is believed attributable to the high-concentration glucose in the PD solution. The glucose absorbed from peritoneal cavity raises the risk of ‘glucose toxicity’, leading to insulin resistance and beta cell failure. Clinical similarity can be found in postprandial hyperglycemia, which is known to be associated with oxidative stress, endothelial dysfunction, NF-κb, and inflammation, affecting myocardial blood flow. Moreover, it is a proven independent risk factor of coronary artery disease in patients with type 2 diabetes, particularly of female gender. Though speculative yet, glucose toxicity might explain a higher mortality of PD patients after the first year compared with those on hemodialysis (more so in female, advanced-age patients with diabetes. Also included in the picture are glucose degradation products (GDPs generated along the course of heat sterilization or storage of the PD solution. They have been shown to induce apoptosis of peritoneal mesothelial cells, renal tubular epithelial cells, and endothelial cells, while spurring production of TGF-β and VEGF and facilitating epithelial mesenchymal transition. GDPs provide a stronger reactivity than glucose in the formation of AGEs, a known cause for microvascular complications and arteriosclerosis. Unfortunately, clinical studies using a low-GDP PD solution have provided mixed results on the residual renal function, peritonitis, peritoneal

Fluid-structure interaction analysis for pressurizer surge line subjected to thermal stratification

International Nuclear Information System (INIS)

Kang, Dong Gu; Jhung, Myung Jo; Chang, Soon Heung

2011-01-01

Research highlights: → Temperature of surge line due to stratified flow is defined using CFD analysis. → Fluid-structure interaction analysis is performed to investigate the response characteristics due to thermal stress. → Fatigue usage factors due to thermal stratification are relatively low. → Simplifying temperature distribution in surge line is not always conservative. - Abstract: Serious mechanical damages such as cracks and plastic deformations due to excessive thermal stress caused by thermal stratification have been experienced in several nuclear power plants. In particular, the thermal stratification in the pressurizer surge line has been addressed as one of the significant safety and technical issues. In this study, a detailed unsteady computational fluid dynamics (CFD) analysis involving conjugate heat transfer analysis is performed to obtain the transient temperature distributions in the wall of the pressurizer surge line subjected to stratified internal flows either during out-surge or in-surge operation. The thermal loads from CFD calculations are transferred to the structural analysis code which is employed for the thermal stress analysis to investigate the response characteristics, and the fatigue analysis is ultimately performed. In addition, the thermal stress and fatigue analysis results obtained by applying the realistic temperature distributions from CFD calculations are compared with those by assuming the simplified temperature distributions to identify some requirements for a realistic and conservative thermal stress analysis from a safety point of view.

The value of wetlands in protecting southeast louisiana from hurricane storm surges.

Science.gov (United States)

Barbier, Edward B; Georgiou, Ioannis Y; Enchelmeyer, Brian; Reed, Denise J

2013-01-01

The Indian Ocean tsunami in 2004 and Hurricanes Katrina and Rita in 2005 have spurred global interest in the role of coastal wetlands and vegetation in reducing storm surge and flood damages. Evidence that coastal wetlands reduce storm surge and attenuate waves is often cited in support of restoring Gulf Coast wetlands to protect coastal communities and property from hurricane damage. Yet interdisciplinary studies combining hydrodynamic and economic analysis to explore this relationship for temperate marshes in the Gulf are lacking. By combining hydrodynamic analysis of simulated hurricane storm surges and economic valuation of expected property damages, we show that the presence of coastal marshes and their vegetation has a demonstrable effect on reducing storm surge levels, thus generating significant values in terms of protecting property in southeast Louisiana. Simulations for four storms along a sea to land transect show that surge levels decline with wetland continuity and vegetation roughness. Regressions confirm that wetland continuity and vegetation along the transect are effective in reducing storm surge levels. A 0.1 increase in wetland continuity per meter reduces property damages for the average affected area analyzed in southeast Louisiana, which includes New Orleans, by $99-$133, and a 0.001 increase in vegetation roughness decreases damages by $24-$43. These reduced damages are equivalent to saving 3 to 5 and 1 to 2 properties per storm for the average area, respectively.

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab.

Science.gov (United States)

Lee, Hyun Tae; Lee, Ju Yeon; Lim, Heejin; Lee, Sang Hyung; Moon, Yu Jeong; Pyo, Hyo Jeong; Ryu, Seong Eon; Shin, Woori; Heo, Yong-Seok

2017-07-17

In 2016 and 2017, monoclonal antibodies targeting PD-L1, including atezolizumab, durvalumab, and avelumab, were approved by the FDA for the treatment of multiple advanced cancers. And many other anti-PD-L1 antibodies are under clinical trials. Recently, the crystal structures of PD-L1 in complex with BMS-936559 and avelumab have been determined, revealing details of the antigen-antibody interactions. However, it is still unknown how atezolizumab and durvalumab specifically recognize PD-L1, although this is important for investigating novel binding sites on PD-L1 targeted by other therapeutic antibodies for the design and improvement of anti-PD-L1 agents. Here, we report the crystal structures of PD-L1 in complex with atezolizumab and durvalumab to elucidate the precise epitopes involved and the structural basis for PD-1/PD-L1 blockade by these antibodies. A comprehensive comparison of PD-L1 interactions with anti-PD-L1 antibodies provides a better understanding of the mechanism of PD-L1 blockade as well as new insights into the rational design of improved anti-PD-L1 therapeutics.

Quantification of Sediment Transport During Glacier Surges and its Impact on Landform Architecture

DEFF Research Database (Denmark)

Kjær, Kurt H.; Schomacker, Anders; Korsgaard, Niels Jákup

) for 1945, prior to the last surge in 1964, and for 2003 in order to assess the effect of the surge on the sediment architecture in the forefield. The pre- and post-surge DEMs allow direct quantification of the sediment volumes that were re-distributed in the forefield by the surging ice mass in 1964...... or glaciofluvial outwash fans. Mapping of the sediment thickness in the glacier forefield shows higher accumulation along ice marginal positions related to wedge formation during extremely rapid ice flow. Fast flow was sustained by overpressurized water causing sediment-bedrock decoupling beneath a thick sediment...... architecture occurs distal to the 1810 ice margin, where the 1890 surge advanced over hitherto undeformed sediments. Proximal to the 1810 ice margin, the landscape have been transgressed by either one or two glaciers (in 1890 and 1964). The most complex landscape architecture is found proximal to the 1964 ice...

MAGNETIC-RECONNECTION GENERATED SHOCK WAVES AS A DRIVER OF SOLAR SURGES

International Nuclear Information System (INIS)

Yang, Heesu; Chae, Jongchul; Park, Hyungmin; Song, Dong-uk; Cho, Kyuhyoun; Lim, Eun-Kyung; Lee, Kyoung-sun

2014-01-01

We found that a surge consists of multiple shock features. In our high-spatiotemporal spectroscopic observation of the surge, each shock is identified with the sudden appearance of an absorption feature at the blue wings of the Ca II 8542 Å line and Hα line that gradually shifts to the red wings. The shock features overlap with one another with the time interval of 110 s, which is much shorter than the duration of each shock feature, 300-400 s. This finding suggests that the multiple shocks might not have originated from a train of sinusoidal waves generated by oscillations and flows in the photosphere. As we found the signature of the magnetic flux cancelations at the base of the surge, we conclude that the multiple shock waves in charge of the surge were generated by the magnetic reconnection that occurred in the low atmosphere in association with the flux cancelation

Mild parkinsonian signs in the elderly--is there an association with PD? Crossectional findings in 992 individuals.

Directory of Open Access Journals (Sweden)

Stefanie Lerche

Full Text Available Mild parkinsonian signs (MPS are common in the elderly population, and have been associated with vascular diseases, mild cognitive impairment and dementia; however their relation to Parkinson's disease (PD is unclear. Hypothesizing that individuals with MPS may reflect a pre-stage of PD, i.e. a stage in which the nigrostriatal system is already affected although to a milder degree than at the time of PD diagnosis, aim of this study was to evaluate the similarities between MPS and PD.The TREND study is a prospective cross-sectional cohort study in individuals >50 years with biennial assessments designed to identify markers for an earlier diagnosis of Parkinson's and Alzheimer's disease. For this substudy 992 individuals were included for analyses (892 controls, 73 MPS individuals, 27 PD patients. Parameters defining risk of PD (sex, age, positive family history, prodromal markers (hyposmia, REM sleep behavior disorder, depression and autonomic failure as well as quantitative fine motor, axial motor and cognitive parameters were compared between the three cohorts.As expected, PD patients differed from controls with regard to 12 of 15 of the assessed parameters. MPS individuals differed significantly from controls in 12 of the PD-associated parameters, but differed from PD only in 5 parameters.This study shows that individuals with MPS share many prodromal and clinical markers of PD with PD patients, implying that either a common dynamic process or similar constitutional factors occur in MPS individuals and PD patients.

A new on-line leakage current monitoring system of ZnO surge arresters

International Nuclear Information System (INIS)

Lee, Bok-Hee; Kang, Sung-Man

2005-01-01

This paper presents a new on-line leakage current monitoring system of zinc oxide (ZnO) surge arresters. To effectively diagnose the deterioration of ZnO surge arresters, a new algorithm and on-line leakage current detection device, which uses the time-delay addition method, for discriminating the resistive and capacitive currents was developed to use in the aging test and durability evaluation for ZnO arrester blocks. A computer-based measurement system of the resistive leakage current, the on-line monitoring device can detect accurately the leakage currents flowing through ZnO surge arresters for power frequency ac applied voltages. The proposed on-line leakage current monitoring device of ZnO surge arresters is more highly sensitive and gives more linear response than the existing devices using the detection method of the third harmonic leakage currents. Therefore, the proposed leakage current monitoring device can be useful for predicting the defects and performance deterioration of ZnO surge arresters in power system applications

A Case of Hypertensive Crisis without a Surge in Adrenal Hormones after Radiofrequency Ablation as a Treatment for Primary Hepatocellular Carcinoma.

Science.gov (United States)

Lee, Kyung Jin; Ryu, Soo Hyung

2017-10-25

Radiofrequency ablation (RFA) is a minimally invasive procedure that has been considered as a relatively safe treatment for patients with small hepatocellular carcinoma (HCC). However, RFA has been shown to be associated with complications including mechanical and thermal damage. A 74-year-old man with hepatitis C virus-associated HCC was admitted to our hospital. Abdominal computed tomography revealed two lobulated-HCC in segments 4 and 5. He had no medical history of hypertension and cardiac disease. During RFA, blood pressure was elevated to 200/140 mmHg. There was no evidence of pulmonary embolism, aortic dissection, or ischemic heart disease. Laboratory findings for catecholamine surge were all within normal limits. After continuous intravenous nitroglycerin and oral beta-blocker treatment, patient's blood pressure gradually decreased and back within the normal range. Hypertensive crisis after RFA treatment for HCC is rare. Most reported cases of hypertensive crisis during RFA were related to adrenal gland injury with a release of catecholamine. In our case, the site of HCC was not close to the adrenal gland, and there was no evidence of catecholamine surge. Herein, we report a very rare case of hypertensive crisis without a surge in adrenal hormones after RFA treatment for HCC.

[Analysis of articles published in Chin J Surg since founded in 1951].

Science.gov (United States)

Xia, Shuang; Li, Jing

2016-01-01

To discuss the characteristics of the articles published in Chin J Surg from 1951 to 2015. The journals and articles of Acad Surg from 1951 to 1952 and Chin J Surg from 1953 to 2015 were analyzed. The subjects, foundation, basic medical study, international cooperation of the articles were recorded. In 65 years, there were 20 090 academic articles published in Chin J Surg. The proportions of general surgery, orthopedic surgery, thoracocardiac surgery, urology surgery and neurosurgery articles were 34.08%, 17.96%, 13.09%, 11.91% and 5.85%, respectively. There were 14.83% (1 728/11 653) articles receiving foundation, and 9.42% (1 817/19 290) articles reporting basic medical study. There were 14.8% articles from international authors and 119 articles with international cooperation. From 2000 to 2003, 29 articles in original English were published. The coverage of Chin J Surg contains all the fields of surgery. It tends to publish the studies focus on clinical issues.Through reinforcing the content plan and optimizing the show form, the more Chinese surgical research achievements could be shared by the surgeons worldwide.

The insulation coordination and surge arrester design for HTS cable system in Icheon substation

Energy Technology Data Exchange (ETDEWEB)

Lee, Hansang, E-mail: Hansang80@korea.ac.kr [School of Railway and Electrical Engineering, Kyungil University, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 712-701 (Korea, Republic of); Yoon, Dong-Hee [Department of New and Renewable Energy, Kyungil University, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 712-701 (Korea, Republic of); Lee, Seung-Ryul [Korea Electrotechnology Research Institute, Naeson-dong, Uiwang-si, Gyeonggi-do 437-080 (Korea, Republic of); Yang, Byeong-Mo [Korea Electric Power Research Institute, Munji-dong, Yuseong-gu, Daejeon 305-760 (Korea, Republic of); Jang, Gilsoo, E-mail: gjang@korea.ac.kr [School of Electrical Engineering, Korea University, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-713 (Korea, Republic of)

2013-01-15

Highlights: ► It is necessary to study lightning response of the HTS cable. ► The analytic model has been developed for the HTS cable in the Icheon substation. ► Well-designed surge arrester has been verified through PSCAD/EMTDC simulations. -- Abstract: This paper proposes an insulation coordination and surge arrester design for HTS (High-Temperature Superconducting) cable system in Icheon substation in Korea. In the aspect of the economic analysis, since the HTS cable is very expensive, the insulation coordination to prevent the dielectric breakdown caused by the lightning surge should be considered carefully. Also, in the aspect of the power system reliability, since the HTS cable has much more capacity compared than conventional power cables and the ripple effect from the HTS cable failure may lead to the wide area blackout, an intensive study for insulation coordination from lightning surge is one of the most important considerations. In this paper, the insulation coordination for lightning surge is verified using HTS cable and power equipment models and the design of the proper surge arrester is proposed.

Use of historical information in extreme storm surges frequency analysis

Science.gov (United States)

Hamdi, Yasser; Duluc, Claire-Marie; Deville, Yves; Bardet, Lise; Rebour, Vincent

2013-04-01

The prevention of storm surge flood risks is critical for protection and design of coastal facilities to very low probabilities of failure. The effective protection requires the use of a statistical analysis approach having a solid theoretical motivation. Relating extreme storm surges to their frequency of occurrence using probability distributions has been a common issue since 1950s. The engineer needs to determine the storm surge of a given return period, i.e., the storm surge quantile or design storm surge. Traditional methods for determining such a quantile have been generally based on data from the systematic record alone. However, the statistical extrapolation, to estimate storm surges corresponding to high return periods, is seriously contaminated by sampling and model uncertainty if data are available for a relatively limited period. This has motivated the development of approaches to enlarge the sample extreme values beyond the systematic period. The nonsystematic data occurred before the systematic period is called historical information. During the last three decades, the value of using historical information as a nonsystematic data in frequency analysis has been recognized by several authors. The basic hypothesis in statistical modeling of historical information is that a perception threshold exists and that during a giving historical period preceding the period of tide gauging, all exceedances of this threshold have been recorded. Historical information prior to the systematic records may arise from high-sea water marks left by extreme surges on the coastal areas. It can also be retrieved from archives, old books, earliest newspapers, damage reports, unpublished written records and interviews with local residents. A plotting position formula, to compute empirical probabilities based on systematic and historical data, is used in this communication paper. The objective of the present work is to examine the potential gain in estimation accuracy with the

Periodontal disease and women's health.

Science.gov (United States)

Martelli, Maria Luisa; Brandi, Maria Luisa; Martelli, Marialaura; Nobili, Piero; Medico, Enzo; Martelli, Francesco

2017-06-01

Periodontal disease (PD) is a multifactorial inflammatory condition in which inappropriate interaction between the host immune response and specific groups of bacterial pathogens leads to destruction of connective and bone tissues supporting the tooth. Dissemination of pathogens, toxins, and immune complexes from and to periodontal lesions is at the basis of the increasingly recognized association between PD and various systemic diseases (SDs). Considering the growing attention of the medical community to "gender medicine", this review focuses on the association between PD and six systemic conditions heavily impacting women's health, with the aim of providing evidence in support of a joint effort between physicians and dentists to improve clinical management of these conditions. We considered systematic reviews, meta-analyses and narrative reviews evaluating all possible associations between periodontitis, systemic diseases and women. Gender prevalence for PD is discordant, but the literature strongly supports an association between PD and female infertility and adverse pregnancy outcomes. Moreover, PD is bidirectionally linked to several systemic diseases characterized by an established female gender bias, i.e. osteoporosis (OP), cardiovascular diseases (CVD), autoimmunity, Alzheimer's disease (AD) and cancer. Overall, the literature data reviewed here provides a strong foundation for further characterization of molecular and microbial drivers of PD and of several female-prevalent systemic diseases, highlighting the possible importance of a good oral condition in preventing or attenuating women's systemic diseases.

Anti-tumor immunotherapy by blockade of the PD-1/PD-L1 pathway with recombinant human PD-1-IgV.

Science.gov (United States)

Zhang, C; Wu, S; Xue, X; Li, M; Qin, X; Li, W; Han, W; Zhang, Y

2008-01-01

Blockade of the programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) pathway can delay tumor growth and prolong the survival of tumor-bearing mice. The extracellular immunoglobulin (Ig) V domain of PD-1 is important for the interaction between PD-1 and PD-L1, suggesting that PD-1-IgV may be a potential target for anti-tumor immunotherapy. The extracellular sequence of human PD-1-IgV (hPD-1-IgV) was expressed in Escherichia coli and purified. The anti-tumor effect of hPD-1-IgV on tumor-bearing mice was tested. hPD-1-IgV recombinant protein could bind PD-L1 at molecular and cellular levels and enhance Cytotoxic T Lymphocyte (CTL) activity and anti-tumor effect on tumor-bearing mice in vivo. The percentage of CD4(+)CD25(+) T cells in tumor-bearing mice was decreased compared with control mice after administration of the recombinant protein. Our results suggest that inhibition of the interaction between PD-1 and PD-L1 by hPD-1-IgV may be a promising strategy for specific tumor immunotherapy.

Data Assimilation within the Advanced Circulation (ADCIRC) Modeling Framework for Hurricane Storm Surge Forecasting

KAUST Repository

Butler, T.

2012-07-01

Accurate, real-time forecasting of coastal inundation due to hurricanes and tropical storms is a challenging computational problem requiring high-fidelity forward models of currents and water levels driven by hurricane-force winds. Despite best efforts in computational modeling there will always be uncertainty in storm surge forecasts. In recent years, there has been significant instrumentation located along the coastal United States for the purpose of collecting data—specifically wind, water levels, and wave heights—during these extreme events. This type of data, if available in real time, could be used in a data assimilation framework to improve hurricane storm surge forecasts. In this paper a data assimilation methodology for storm surge forecasting based on the use of ensemble Kalman filters and the advanced circulation (ADCIRC) storm surge model is described. The singular evolutive interpolated Kalman (SEIK) filter has been shown to be effective at producing accurate results for ocean models using small ensemble sizes initialized by an empirical orthogonal function analysis. The SEIK filter is applied to the ADCIRC model to improve storm surge forecasting, particularly in capturing maximum water levels (high water marks) and the timing of the surge. Two test cases of data obtained from hindcast studies of Hurricanes Ike and Katrina are presented. It is shown that a modified SEIK filter with an inflation factor improves the accuracy of coarse-resolution forecasts of storm surge resulting from hurricanes. Furthermore, the SEIK filter requires only modest computational resources to obtain more accurate forecasts of storm surge in a constrained time window where forecasters must interact with emergency responders.

Peyronie's Disease: Still a Surgical Disease.

Science.gov (United States)

Martinez, Daniel; Ercole, Cesar E; Hakky, Tariq S; Kramer, Andrew; Carrion, Rafael

2012-01-01

Peyronie's Disease (PD) remains a challenging and clinically significant morbid condition. Since its first description by François Gigot de la Peyronie, much of the treatment for PD remains nonstandardized. PD is characterized by the formation of fibrous plaques at the level of the tunica albuginea. Clinical manifestations include morphologic changes, such as curvatures and hourglass deformities. Here, we review the common surgical techniques for the management of patients with PD.

Self-Reported Symptoms of Parkinson's Disease by Sex and Disease Duration.

Science.gov (United States)

Shin, Ju Young; Pohlig, Ryan T; Habermann, Barbara

2017-11-01

Parkinson's disease (PD) is a neurodegenerative disease with a wide range of symptom presentations. The purpose of this research was to compare self-reported motor and non-motor symptoms of PD by sex and disease duration. This study was a cross-sectional descriptive survey in community-dwelling people with PD. A total of 141 participants (64.6% response rate; 59.6% men; M age = 69.7 years) were included. Males reported more rigidity, speech problems, sexual dysfunction, memory problems, and socializing problems than females. The number of motor symptoms in three groups divided by increments of 5 years was significantly increased. Postural instability, freezing, off periods, dyskinesia, speech problems, and hallucinations/psychosis were significantly increased as the disease duration increased. Thorough assessment of motor and non-motor symptoms could decrease the risk of inadequate symptom management. Provision of information regarding PD symptoms at each stage may help people with PD and their caregivers in planning their future care and life.

Simulating Storm Surge Impacts with a Coupled Atmosphere-Inundation Model with Varying Meteorological Forcing

Directory of Open Access Journals (Sweden)

Alexandra N. Ramos Valle

2018-04-01

Full Text Available Storm surge events have the potential to cause devastating damage to coastal communities. The magnitude of their impacts highlights the need for increased accuracy and real-time forecasting and predictability of storm surge. In this study, we assess two meteorological forcing configurations to hindcast the storm surge of Hurricane Sandy, and ultimately support the improvement of storm surge forecasts. The Weather Research and Forecasting (WRF model is coupled to the ADvanced CIRCulation Model (ADCIRC to determine water elevations. We perform four coupled simulations and compare storm surge estimates resulting from the use of a parametric vortex model and a full-physics atmospheric model. One simulation is forced with track-based meteorological data calculated from WRF, while three simulations are forced with the full wind and pressure field outputs from WRF simulations of varying resolutions. Experiments were compared to an ADCIRC simulation forced by National Hurricane Center best track data, as well as to station observations. Our results indicated that given accurate meteorological best track data, a parametric vortex model can accurately forecast maximum water elevations, improving upon the use of a full-physics coupled atmospheric-surge model. In the absence of a best track, atmospheric forcing in the form of full wind and pressure field from a high-resolution atmospheric model simulation prove reliable for storm surge forecasting.

Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis

Directory of Open Access Journals (Sweden)

Peng-Fei Wang

2017-10-01

Full Text Available Background: Treatment of cancers with programmed cell death protein 1 (PD-1 pathway inhibitors can lead to immune-related adverse events (irAEs, which could be serious and even fetal. Therefore, clinicians should be aware of the characteristics of irAEs associated with the use of such drugs.Methods: The MEDLINE, EMBASE, and Cochrane databases were searched to find potential studies using the following strategies: anti-PD-1/PD-L1 treatment; irAEs; and cancer. R© package Meta was used to pool incidence.Results: Forty-six studies representing 12,808 oncologic patients treated with anti-PD-1/PD-L1 agents were included in the meta-analysis. The anti-PD-1/PD-L1 agents included nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, and BMS-936559. The tumor types were melanomas, Hodgkin lymphomas, urothelial carcinomas, breast cancers, non-small cell lung cancers, renal cell carcinomas (RCC, colorectal cancers, and others. We described irAEs according to organ systems, namely, the skin (pruritus, rash, maculopapular rash, vitiligo, and dermatitis, endocrine system (hypothyroidism, hyperthyroidism, hypophysitis, thyroiditis, and adrenal insufficiency, digestive system (colitis, diarrhea, pancreatitis, and increased AST/ALT/bilirubin, respiratory system (pneumonitis, lung infiltration, and interstitial lung disease, and urinary system (increased creatinine, nephritis, and renal failure. In patients treated with the PD-1 signaling inhibitors, the overall incidence of irAEs was 26.82% (95% CI, 21.73–32.61; I2, 92.80 in any grade and 6.10% (95% CI, 4.85–7.64; I2, 52.00 in severe grade, respectively. The development of irAEs was unrelated to the dose of anti-PD-1/PD-L1 agents. The incidence of particular irAEs varied when different cancers were treated with different drugs. The incidence of death due to irAEs was around 0.17%.Conclusion: The occurrence of irAEs was organ-specific and related to drug and tumor types.

Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups

OpenAIRE

Xue Jin; Xiaoxia Shi; Jintian Gao; Tongbin Xu; Kedong Yin

2018-01-01

Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is di...

Numerical modelling of tides and storm surges in the Bay of Bengal

Digital Repository Service at National Institute of Oceanography (India)

Sindhu, B.

were done. A storm surge model was developed to simulate total water levels and derived surges caused by low pressure systems identified during the past 27 years (1974-2000) in the Bay of Bengal. Study also estimated the return levels of extreme sea...

Inflammatory bowel disease and risk of Parkinson's disease in Medicare beneficiaries.

Science.gov (United States)

Camacho-Soto, Alejandra; Gross, Anat; Searles Nielsen, Susan; Dey, Neelendu; Racette, Brad A

2018-05-01

Gastrointestinal (GI) dysfunction precedes the motor symptoms of Parkinson's disease (PD) by several years. PD patients have abnormal aggregation of intestinal α-synuclein, the accumulation of which may be promoted by inflammation. The relationship between intestinal α-synuclein aggregates and central nervous system neuropathology is unknown. Recently, we observed a possible inverse association between inflammatory bowel disease (IBD) and PD as part of a predictive model of PD. Therefore, the objective of this study was to examine the relationship between PD risk and IBD and IBD-associated conditions and treatment. Using a case-control design, we identified 89,790 newly diagnosed PD cases and 118,095 population-based controls >65 years of age using comprehensive Medicare data from 2004-2009 including detailed claims data. We classified IBD using International Classification of Diseases version 9 (ICD-9) diagnosis codes. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between PD and IBD. Covariates included age, sex, race/ethnicity, smoking, Elixhauser comorbidities, and health care use. PD was inversely associated with IBD overall (OR = 0.85, 95% CI 0.80-0.91) and with both Crohn's disease (OR = 0.83, 95% CI 0.74-0.93) and ulcerative colitis (OR = 0.88, 95% CI 0.82-0.96). Among beneficiaries with ≥2 ICD-9 codes for IBD, there was an inverse dose-response association between number of IBD ICD-9 codes, as a potential proxy for IBD severity, and PD (p-for-trend = 0.006). IBD is associated with a lower risk of developing PD. Copyright © 2018 Elsevier Ltd. All rights reserved.

Increased level of morning surge in blood pressure in normotensives: A cross-sectional study from Pakistan

International Nuclear Information System (INIS)

Almas, A.; Sultan, F. T.; Kazmi, K.

2016-01-01

Objective: To determine the mean morning surge (MS) in blood pressure, the frequency of increased morning surge in normotensive subjects, and to compare those with morning surge with those without MS. Study Design: A cross-sectional, comparative study. Place and Duration of Study: The Department of Medicine, The Aga Khan University Hospital, Karachi, from April 2011 to March 2012. Methodology: Adult normotensive healthy volunteers aged 35 to 65 years were inducted. Their ambulatory blood pressure (ABP) was measured over a 24-hour period, using digital ambulatory blood pressure monitors. Morning surge was calculated as the average of four readings after waking minus the lowest three nocturnal readings. Increased morning surge was defined as > 11 mm Hg in systolic (SBP) or > 12 mm Hg in diastolic (DBP). Dipping was defined as > 10% dipping in blood pressure. Results: Eighty-two healthy volunteers were recruited. Their mean age was 36.9 ± 1.2 years; 74.4 (61%) were men, and 58.5 (48%) woke up for morning prayers. Mean overall SBP was 113 ± 1.6 mm Hg, overall DBP was 73.9 ± 0.7 mm Hg, and overall heart rate was 75 (10) beats/minute. Mean morning surge was 17.6 ± 1.0 mm Hg in SBP and 16.0 ± 0.8 mm Hg in DBP. The frequency of increased morning surge was 66 (80.5%) in SBP, and 57 (69%) in DBP. On comparison of participants with normal morning surge and increased morning surge in SBP, there was a significant difference in non-dipping status (13.4% in normal vs. 18.3% in increased morning surge, p= 0.001). Conclusion: Mean morning surge in SBP and DBP are relatively higher in this subset population in a tertiary care center in Pakistan. These values are higher than those reported in the literature. (author)

Nonmotor symptoms in genetic Parkinson disease

DEFF Research Database (Denmark)

Kasten, Meike; Kertelge, Lena; Brüggemann, Norbert

2010-01-01

To review current knowledge on nonmotor symptoms (NMS), particularly psychiatric features, in genetic Parkinson disease (PD) and to provide original data for genetic and idiopathic PD.......To review current knowledge on nonmotor symptoms (NMS), particularly psychiatric features, in genetic Parkinson disease (PD) and to provide original data for genetic and idiopathic PD....

Modeling Flood Inundation Induced by River Flow and Storm Surges over a River Basin

Directory of Open Access Journals (Sweden)

Wei-Bo Chen

2014-10-01

Full Text Available Low-lying coastal regions and their populations are at risk during storm surge events and high freshwater discharges from upriver. An integrated storm surge and flood inundation modeling system was used to simulate storm surge and inundation in the Tsengwen River basin and the adjacent coastal area in southern Taiwan. A three-dimensional hydrodynamic model with an unstructured grid was used, which was driven by the tidal elevation at the open boundaries and freshwater discharge at the upriver boundary. The model was validated against the observed water levels for three typhoon events. The simulation results for the model were in reasonable agreement with the observational data. The model was then applied to investigate the effects of a storm surge, freshwater discharge, and a storm surge combined with freshwater discharge during an extreme typhoon event. The super Typhoon Haiyan (2013 was artificially shifted to hit Taiwan: the modeling results showed that the inundation area and depth would cause severe overbank flow and coastal flooding for a 200 year return period flow. A high-resolution grid model is essential for the accurate simulation of storm surges and inundation.

Progression of the 2011-2012 Surge of Bering Glacier and Bagley Ice Field, Alaska

Science.gov (United States)

Herzfeld, U. C.; McDonald, B.; Stachura, M.; Hale, R.; Trantow, T.; Weltman, A.; Chen, P.

2012-12-01

Bering Glacier, Alaska, started a surge in late spring 2011. The surge reached the ice front in May 2011 and extended into Bagley Ice Field by summer 2011. New surge-related crevassing was observed in July 2012. We collected aerial observations, including systematic videographic and photographic imagery, GPS data and laser altimeter data in September 2011 and in July 2012. In this talk, an analysis of surge progression and comparison to the early, mature and late stages of the 1993-1995 surge of Bering Glacier and Bagley Ice Field will be presented. A suite of approaches will be used to this end: Analysis of elevation changes based on CryoSat data, 2009 and 2010 IceBridge data and 2011 and 2012 laser altimeter data collected by our group, geostatistical classification of crevasse types based on imagery, classification of laser altimeter data and analysis of high-resolution satellite imagery (Worldview and GEOS).

Identification of storm surge vulnerable areas in the Philippines through the simulation of Typhoon Haiyan-induced storm surge levels over historical storm tracks

Science.gov (United States)

Lapidez, J. P.; Tablazon, J.; Dasallas, L.; Gonzalo, L. A.; Cabacaba, K. M.; Ramos, M. M. A.; Suarez, J. K.; Santiago, J.; Lagmay, A. M. F.; Malano, V.

2015-07-01

Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR) on 7 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the storm surge and strong winds. Storm surges up to a height of 7 m were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards (Project NOAH) which is the flagship disaster mitigation program of the Department of Science and Technology (DOST) of the Philippine government to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948-2013. One product of this study is a list of the 30 most vulnerable coastal areas that can be used as a basis for choosing priority sites for further studies to implement appropriate site-specific solutions for flood risk management. Another product is the storm tide inundation maps that the local government units can use to develop a risk-sensitive land use plan for identifying appropriate areas to build residential buildings, evacuation sites, and other critical facilities and lifelines. The maps can also be used to develop a disaster response plan and evacuation scheme.

Identification of storm surge vulnerable areas in the Philippines through the simulation of Typhoon Haiyan-induced storm surge levels over historical storm tracks

Directory of Open Access Journals (Sweden)

J. P. Lapidez

2015-07-01

Full Text Available Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR on 7 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the storm surge and strong winds. Storm surges up to a height of 7 m were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards (Project NOAH which is the flagship disaster mitigation program of the Department of Science and Technology (DOST of the Philippine government to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948–2013. One product of this study is a list of the 30 most vulnerable coastal areas that can be used as a basis for choosing priority sites for further studies to implement appropriate site-specific solutions for flood risk management. Another product is the storm tide inundation maps that the local government units can use to develop a risk-sensitive land use plan for identifying appropriate areas to build residential buildings, evacuation sites, and other critical facilities and lifelines. The maps can also be used to develop a disaster response plan and evacuation scheme.

Periodontal disease and non-communicable diseases. Strength of bidirectional associations

OpenAIRE

Kassier, SM

2016-01-01

Periodontal disease (PD), along with cardiovascular and circulatory disease, diabetes mellitus, chronic respiratory disease and obesity, are globally regarded as some of the major non-communicable diseases (NCDs). The association between PD and these systemic illnesses is described as bidirectional. Gaining an understanding of the strength of the proposed associations between these diseases is important, as it will enable health professionals to identify common risk factors that will allow fo...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... Misconceptions About Parkinson's Disease? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... Overview of Parkinson's Disease OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis Is There a Cure ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... Progression of the Disease? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ...

Investigation of Genetic Variants Associated with Alzheimer Disease in Parkinson Disease Cognition.

Science.gov (United States)

Barrett, Matthew J; Koeppel, Alexander F; Flanigan, Joseph L; Turner, Stephen D; Worrall, Bradford B

2016-01-01

Meta-analysis of genome-wide association studies have implicated multiple single nucleotide polymorphisms (SNPs) and associated genes with Alzheimer disease. The role of these SNPs in cognitive impairment in Parkinson disease (PD) remains incompletely evaluated. The objective of this study was to test alleles associated with risk of Alzheimer disease for association with cognitive impairment in Parkinson disease (PD). Two datasets with PD subjects accessed through the NIH database of Genotypes and Phenotypes contained both single nucleotide polymorphism (SNP) arrays and mini-mental state exam (MMSE) scores. Genetic data underwent rigorous quality control and we selected SNPs for genes associated with AD other than APOE. We constructed logistic regression and ordinal regression models, adjusted for sex, age at MMSE, and duration of PD, to assess the association between selected SNPs and MMSE score. In one dataset, PICALM rs3851179 was associated with cognitive impairment (MMSE  70 years old (OR = 2.3; adjusted p-value = 0.017; n = 250) but not in PD subjects ≤ 70 years old. Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD. It is important that future studies consider the interaction of age and genetic risk factors in the development of cognitive impairment in PD.

The Development of Storm Surge Ensemble Prediction System and Case Study of Typhoon Meranti in 2016

Science.gov (United States)

Tsai, Y. L.; Wu, T. R.; Terng, C. T.; Chu, C. H.

2017-12-01

Taiwan is under the threat of storm surge and associated inundation, which is located at a potentially severe storm generation zone. The use of ensemble prediction can help forecasters to know the characteristic of storm surge under the uncertainty of track and intensity. In addition, it can help the deterministic forecasting. In this study, the kernel of ensemble prediction system is based on COMCOT-SURGE (COrnell Multi-grid COupled Tsunami Model - Storm Surge). COMCOT-SURGE solves nonlinear shallow water equations in Open Ocean and coastal regions with the nested-grid scheme and adopts wet-dry-cell treatment to calculate potential inundation area. In order to consider tide-surge interaction, the global TPXO 7.1 tide model provides the tidal boundary conditions. After a series of validations and case studies, COMCOT-SURGE has become an official operating system of Central Weather Bureau (CWB) in Taiwan. In this study, the strongest typhoon in 2016, Typhoon Meranti, is chosen as a case study. We adopt twenty ensemble members from CWB WRF Ensemble Prediction System (CWB WEPS), which differs from parameters of microphysics, boundary layer, cumulus, and surface. From box-and-whisker results, maximum observed storm surges were located in the interval of the first and third quartile at more than 70 % gauge locations, e.g. Toucheng, Chengkung, and Jiangjyun. In conclusion, the ensemble prediction can effectively help forecasters to predict storm surge especially under the uncertainty of storm track and intensity

A genomic pathway approach to a complex disease: axon guidance and Parkinson disease.

Directory of Open Access Journals (Sweden)

Timothy G Lesnick

2007-06-01

Full Text Available While major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene variations that predispose to complex diseases. The single gene variants that have been shown to associate reproducibly with complex diseases typically have small effect sizes or attributable risks. However, the joint actions of common gene variants within pathways may play a major role in predisposing to complex diseases (the paradigm of complex genetics. The goal of this study was to determine whether polymorphism in a candidate pathway (axon guidance predisposed to a complex disease (Parkinson disease [PD]. We mined a whole-genome association dataset and identified single nucleotide polymorphisms (SNPs that were within axon-guidance pathway genes. We then constructed models of axon-guidance pathway SNPs that predicted three outcomes: PD susceptibility (odds ratio = 90.8, p = 4.64 x 10(-38, survival free of PD (hazards ratio = 19.0, p = 5.43 x 10(-48, and PD age at onset (R(2 = 0.68, p = 1.68 x 10(-51. By contrast, models constructed from thousands of random selections of genomic SNPs predicted the three PD outcomes poorly. Mining of a second whole-genome association dataset and mining of an expression profiling dataset also supported a role for many axon-guidance pathway genes in PD. These findings could have important implications regarding the pathogenesis of PD. This genomic pathway approach may also offer insights into other complex diseases such as Alzheimer disease, diabetes mellitus, nicotine and alcohol dependence, and several cancers.

Parkinson's Disease Videos

Medline Plus

Full Text Available ... PD Library Search library Topic Type Expert Briefings: Marijuana and PD: What Do We Really Know? Nurse ... Mind Guide to Parkinson's Disease Guide to Deep Brain Stimulation Sleep: A Mind Guide to Parkinson’s Disease ...

Malignant mesothelioma effusions are infiltrated by CD3+ T cells highly expressing PD-L1 and the PD-L1+ tumor cells within these effusions are susceptible to ADCC by the anti-PD-L1 antibody avelumab

Science.gov (United States)

Khanna, Swati; Thomas, Anish; Abate-Daga, Daniel; Zhang, Jingli; Morrow, Betsy; Steinberg, Seth M.; Orlandi, Augusto; Ferroni, Patrizia; Schlom, Jeffrey; Guadagni, Fiorella; Hassan, Raffit

2016-01-01

INTRODUCTION The functional aspects of programmed death 1 (PD-1) and PD ligand 1 (PD-L1) immune checkpoints in malignant mesothelioma have not been studied. METHODS Tumor samples from 65 patients with mesothelioma were evaluated for PD-L1 expression by immunohistochemistry and its prognostic significance. Malignant effusions from patients with pleural and peritoneal mesothelioma were evaluated for PD-1+ and PD-L1+ infiltrating lymphocytes and their role in inducing tumor cell PD-L1 expression. Antibody dependent cellular cytotoxicity (ADCC) of avelumab, a fully humanized IgG1 anti PD-L1 antibody towards primary mesothelioma cell lines was evaluated in presence of autologous and allogeneic NK cells. RESULTS Of 65 pleural and peritoneal mesothelioma tumors examined, 41 (63%) were PD-L1 positive, which was associated with slightly inferior overall survival compared to patients with PD-L1 negative tumors (median 23.0 vs. 33.3 months; p=0.35). The frequency of PD-L1 expression was similar in pleural and peritoneal mesothelioma patients with 62% and 64% of samples positive, respectively. Of nine mesothelioma effusion samples evaluated, the fraction of cells expressing PD-L1 ranged from 12 to 83%. Of 7 patients with paired malignant effusion and peripheral blood mononuclear cells (PBMC) samples, PD-L1 expression was significantly higher on CD3+ T cells present in malignant effusions as compared with PBMC (p=0.016). In addition, CD14+PD-1+ cells were elevated in malignant effusions compared with PBMC (p=0.031). The lymphocytes present in malignant effusions recognized autologous tumor cells and induced IFN-γ-mediated PD-L1 expression on the tumor cell surface. Of the three primary mesothelioma cell lines tested, two were susceptible to avelumab mediated ADCC in presence of autologous NK cells. CONCLUSION The majority of pleural as well as peritoneal mesothelioma express PD-L1. Malignant effusions in this disease are characterized by presence of tumor cells and CD3+ T

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... Patients with Parkinson's Disease? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis CareMAP: Movimientos y Caídas, ...

Runoff-generated debris flows: observations and modeling of surge initiation, magnitude, and frequency

Science.gov (United States)

Kean, Jason W.; McCoy, Scott W.; Tucker, Gregory E.; Staley, Dennis M.; Coe, Jeffrey A.

2013-01-01

Runoff during intense rainstorms plays a major role in generating debris flows in many alpine areas and burned steeplands. Yet compared to debris flow initiation from shallow landslides, the mechanics by which runoff generates a debris flow are less understood. To better understand debris flow initiation by surface water runoff, we monitored flow stage and rainfall associated with debris flows in the headwaters of two small catchments: a bedrock-dominated alpine basin in central Colorado (0.06 km2) and a recently burned area in southern California (0.01 km2). We also obtained video footage of debris flow initiation and flow dynamics from three cameras at the Colorado site. Stage observations at both sites display distinct patterns in debris flow surge characteristics relative to rainfall intensity (I). We observe small, quasiperiodic surges at low I; large, quasiperiodic surges at intermediate I; and a single large surge followed by small-amplitude fluctuations about a more steady high flow at high I. Video observations of surge formation lead us to the hypothesis that these flow patterns are controlled by upstream variations in channel slope, in which low-gradient sections act as “sediment capacitors,” temporarily storing incoming bed load transported by water flow and periodically releasing the accumulated sediment as a debris flow surge. To explore this hypothesis, we develop a simple one-dimensional morphodynamic model of a sediment capacitor that consists of a system of coupled equations for water flow, bed load transport, slope stability, and mass flow. This model reproduces the essential patterns in surge magnitude and frequency with rainfall intensity observed at the two field sites and provides a new framework for predicting the runoff threshold for debris flow initiation in a burned or alpine setting.

Parkinson's Disease Videos

Medline Plus

Full Text Available ... PD Library Search library Topic Type Expert Briefings: Marijuana and PD: What Do We Really Know? Nurse ... PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nurse Webinars: Nursing ...

The dynamics of surge in compression systems

Indian Academy of Sciences (India)

is of interest to study compression-system surge to understand its dynamics in order ... Internal problems like compressor going into rotating stall, resulting in loss of ... of water column, was used for mass-flow measurement at the impeller entry.

Independent Validation of the SEND-PD and Correlation with the MDS-UPDRS Part IA

Directory of Open Access Journals (Sweden)

Mayela Rodríguez-Violante

2014-01-01

Full Text Available Introduction. Neuropsychiatric symptoms in Parkinson’s disease can be assessed by the MDS-UPDRS part IA. The Scale for Evaluation of Neuropsychiatric Disorders in Parkinson’s disease (SEND-PD has been recently developed to assess the severity of some neuropsychiatric symptoms. The objective of this study is to compare the performance of the SEND-PD with the corresponding items of the MDS-UPDRS part IA. Methods. Patients with Parkinson’s disease were evaluated using the MDS-UPDRS and the SEND-PD by independent raters. Partial SEND-PD and neuropsychiatric MDS-UPDRS part IA were constructed with equivalent items for comparison. Results. A total of 260 consecutive patients were included. Overall, 61.2% of the patients did not report any psychotic symptom and 83.5% did not report any ICD symptom. On the other hand, 78.5% of the patients did report at least one symptom related to apathy, depression, or anxiety. The partial SEND-PD score was 2.9±3.1 (range from 0 to 16. The neuropsychiatric MDS-UPDRS part IA score was 2.9±3 (range from 0 to 14. The correlation coefficient between corresponding items ranged from 0.67 to 0.98 and between both summary indexes was rs=0.93 (all, P<0.001. Conclusion. A high association between equivalent items of the SEND-PD and the MDS-UPDRS was found.

Peyronie’s Disease: Still a Surgical Disease

Directory of Open Access Journals (Sweden)

Daniel Martinez

2012-01-01

Full Text Available Peyronie’s Disease (PD remains a challenging and clinically significant morbid condition. Since its first description by François Gigot de la Peyronie, much of the treatment for PD remains nonstandardized. PD is characterized by the formation of fibrous plaques at the level of the tunica albuginea. Clinical manifestations include morphologic changes, such as curvatures and hourglass deformities. Here, we review the common surgical techniques for the management of patients with PD.

Role of cold surge and MJO on rainfall enhancement over indonesia during east asian winter monsoon

Science.gov (United States)

Fauzi, R. R.; Hidayat, R.

2018-05-01

Intensity of precipitation in Indonesia is influenced by convection and propagation of southwest wind. Objective of this study is to analyze the relationship between cold surge and the phenomenon of intra-seasonal climate variability Madden-julian Oscillation (MJO) for affecting precipitation in Indonesia. The data used for identifying the occurrence of cold surge are meridional wind speed data from the ERA-Interim. In addition, this study also used RMM1 and RMM2 index data from Bureau of Meteorology (BOM) for identifying MJO events. The results showed that during East Asian Winter Monsoon (EAWM) in 15 years (2000-2015), there are 362 cold surge events, 186 MJO events, and 113 cold surge events were associated with MJO events. The spread of cold surge can penetrate to equator and brought mass of water vapor that causes dominant precipitation in the Indonesian Sea up to 50-75% from climatological precipitation during EAWM. The MJO convection activity that moves from west to east also increases precipitation, but the distribution of rainfall is wider than cold surge, especially in Eastern Indonesia. MJO and cold surge simultaneously can increase rainfall over 100-150% in any Indonesian region that affected by MJO and cold surge events. The mechanism of heavy rainfall is illustrated by high activity of moisture transport in areas such as Java Sea and coastal areas of Indonesia.

Cognitive impairment in early-stage non-demented Parkinson's disease patients

DEFF Research Database (Denmark)

Pfeiffer, Helle Cecilie Viekilde; Løkkegaard, A; Zoetmulder, Marielle

2013-01-01

In Parkinson's disease (PD), Parkinson's disease dementia (PDD) and Parkinson's disease-mild cognitive impairment (PD-MCI) are common. PD-MCI is a risk factor for developing PDD. Knowledge of cognition in early-stages PD is essential in understanding and predicting the dementia process....

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

Directory of Open Access Journals (Sweden)

M. Onofrj

2013-01-01

Full Text Available Visual Hallucinations (VH are a common non-motor symptom of Parkinson’s Disease (PD and the Lewy body dementias (LBD of Parkinson's disease with dementia (PDD and Dementia with Lewy Bodies (DLB. The origin of VH in PD and LBD is debated: earlier studies considered a number of different possible mechanisms underlying VH including visual disorders, Rapid Eye Movement (REM Sleep Intrusions, dysfunctions of top down or bottom up visual pathways, and neurotransmitter imbalance.

Simulating storm surge inundation and damage potential within complex port facilities

Science.gov (United States)

Mawdsley, Robert; French, Jon; Fujiyama, Taku; Achutan, Kamalasudhan

2017-04-01

Storm surge inundation of port facilities can cause damage to critical elements of infrastructure, significantly disrupt port operations and cause downstream impacts on vital supply chains. A tidal surge in December 2013 in the North Sea partly flooded the Port of Immingham, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. This flooding caused damage to port and rail transport infrastructure and disrupted operations for several weeks. This research aims to improve resilience to storm surges using hydrodynamic modelling coupled to an agent-based model of port operations. Using the December 2013 event to validate flood extent, depth and duration, we ran a high resolution hydrodynamic simulation using the open source Telemac 2D finite element code. The underlying Digital Elevation Model (DEM) was derived from Environment Agency LiDAR data, with ground truthing of the flood defences along the port frontage. Major infrastructure and buildings are explicitly resolved with varying degrees of permeability. Telemac2D simulations are run in parallel and take only minutes on a single 16 cpu compute node. Inundation characteristics predicted using Telemac 2D differ from a simple Geographical Information System 'bath-tub' analysis of the DEM based upon horizontal application of the maximum water level across the port topography. The hydrodynamic simulation predicts less extensive flooding and more closely matches observed flood extent. It also provides more precise depth and duration curves. Detailed spatial flood depth and duration maps were generated for a range of tide and surge scenarios coupled to mean sea-level rise projections. These inundation scenarios can then be integrated with critical asset databases and an agent-based model of port operation (MARS) that is capable of simulating storm surge disruption along wider supply chains. Port operators are able to act on information from a particular

Malignant Mesothelioma Effusions Are Infiltrated by CD3+ T Cells Highly Expressing PD-L1 and the PD-L1+ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab.

Science.gov (United States)

Khanna, Swati; Thomas, Anish; Abate-Daga, Daniel; Zhang, Jingli; Morrow, Betsy; Steinberg, Seth M; Orlandi, Augusto; Ferroni, Patrizia; Schlom, Jeffrey; Guadagni, Fiorella; Hassan, Raffit

2016-11-01

express PD-L1. Malignant effusions in this disease are characterized by the presence of tumor cells and CD3-positive T cells that highly express PD-L1. In addition, mesothelioma tumor cells are susceptible to ADCC by the anti-PD-L1 antibody avelumab. Published by Elsevier Inc.

Impulse control disorder in PD: A lateralized monoaminergic frontostriatal disconnection syndrome?

Science.gov (United States)

Premi, E; Pilotto, A; Garibotto, V; Bigni, B; Turrone, R; Alberici, A; Cottini, E; Poli, L; Bianchi, M; Formenti, A; Cosseddu, M; Gazzina, S; Magoni, M; Bertoli, M; Paghera, B; Borroni, B; Padovani, A

2016-09-01

Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas. 84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM). PD-ICD+ showed a significant reduction of left putaminal and left inferior frontal gyrus tracer uptake compared to PD-ICD-. Functional covariance analysis using left putamen as the seed point showed that, in contrast to ICD-patients, ICD+ patients had no functional covariance with contralateral basal ganglia and ipsilateral cingulate cortex, as index of an impaired inter- and intra-hemispheric dopamine binding in PD-ICD+. the results support and expand the concept of a functional disconnection syndrome linked to ICD symptoms in PD patients through an asymmetric molecular frontostriatal network breakdown with left basal ganglia as central hub. Copyright © 2016 Elsevier Ltd. All rights reserved.

Impacts of Storm Surge Mitigation Strategies on Aboveground Storage Tank Chemical Spill Transport

Science.gov (United States)

Do, C.; Bass, B. J.; Bernier, C.; Samii, A.; Dawson, C.; Bedient, P. B.

2017-12-01

The Houston Ship Channel (HSC), located in the hurricane-prone Houston-Galveston region of the upper Texas Coast, is one of the busiest waterways in the United States and is home to one of the largest petrochemical complexes in the world. Due to the proximity of the HSC to Galveston Bay and the Gulf of Mexico, chemical spills resulting from storm surge damage to aboveground storage tanks (ASTs) pose serious threats to the environment, residential communities, and national/international markets whose activities in the HSC generate billions of dollars annually. In an effort to develop a comprehensive storm surge mitigation strategy for Galveston Bay and its constituents, Rice University's Severe Storm Prediction, Education, and Evacuation from Disasters Center proposed two structural storm surge mitigation concepts, the Mid Bay Structure (MBS) and the Lower Bay Structure (LBS) as components of the Houston-Galveston Area Protection System (H-GAPS) project. The MBS consists of levees along the HSC and a navigational gate across the channel, and the LBS consists of a navigation gate and environmental gates across Bolivar Road. The impacts of these two barrier systems on the fate of AST chemical spills in the HSC have previously been unknown. This study applies the coupled 2D SWAN+ADCIRC model to simulate hurricane storm surge circulation within the Gulf of Mexico and Galveston Bay due to a synthetic storm which results in approximately 250-year surge levels in Galveston Bay. The SWAN+ADCIRC model is run using high-resolution computational meshes that incorporate the MBS and LBS scenarios, separately. The resulting wind and water velocities are then fed into a Lagrangian particle transport model to simulate the spill trajectories of the ASTs most likely to fail during the 250-year proxy storm. Results from this study illustrate how each storm surge mitigation strategy impacts the transport of chemical spills (modeled as Lagrangian particles) during storm surge as

Alternate Care Sites for the Management of Medical Surge in Disasters

Science.gov (United States)

2013-12-01

care facilities are in place  Plan for community based surge hospital bed surge capacity is in place  A 50-bed nursing subunit—per 50,000...attempt to assess the preparedness of the hospital system, HHS/ASPR commissioned The Center for Biosecurity of UPMC to examine various responses to...catastrophic health efforts. The 11 report The Next Challenge in Healthcare Preparedness: Catastrophic Health Events (Center for Biosecurity of UPMC

Control of Surge in Centrifugal Compressors by Active Magnetic Bearings Theory and Implementation

CERN Document Server

Yoon, Se Young; Allaire, Paul E

2013-01-01

Control of Surge in Centrifugal Compressors by Active Magnetic Bearings sets out the fundamentals of integrating the active magnetic bearing (AMB) rotor suspension technology in compressor systems, and describes how this relatively new bearing technology can be employed in the active control of compressor surge. The authors provide a self-contained and comprehensive review of rotordynamics and the fundamentals of the AMB technology. The active stabilization of compressor surge employing AMBs in a machine is fully explored, from the modeling of the instability and the design of feedback controllers, to the implementation and experimental testing of the control algorithms in a specially-constructed, industrial-size centrifugal compression system. The results of these tests demonstrate the great potential of the new surge control method developed in this text. This book will be useful for engineers in industries that involve turbocompressors and magnetic bearings, as well as for researchers and graduate students...

Polylysine-modified polyethylenimine (PEI-PLL) mediated VEGF gene delivery protects dopaminergic neurons in cell culture and in rat models of Parkinson's Disease (PD).

Science.gov (United States)

Sheikh, Muhammad Abid; Malik, Yousra Saeed; Xing, Zhenkai; Guo, Zhaopei; Tian, Huayu; Zhu, Xiaojuan; Chen, Xuesi

2017-05-01

Parkinson's Disease (PD) is a chronic neurodegenerative disorder characterized by motor deficits which result from the progressive loss of dopaminergic neurons. Gene therapy using growth factors such as VEGF seems to be a viable approach for potential therapeutic treatment of PD. In this study, we utilized a novel non-viral gene carrier designated as PEI-PLL synthesized by our laboratory to deliver VEGF gene to study its effect by using both cell culture as well as animal models of PD. For cell culture experiments, we utilized 6-hydroxydopamine (6-OHDA) mediated cell death model of MN9D cells following transfection with either a control plasmid or VEGF expressing plasmid. As compared to control transfected cells, PEI-PLL mediated VEGF gene delivery to MN9D cells resulted in increased cell viability, increase in the number of Tyrosine hydroxylase (TH) positive cells and decreased apoptosis following 6-OHDA insult. Next, we studied the therapeutic potential of PEI-PLL mediated VEGF gene delivery in SNPc by using unilateral 6-OHDA Medial forebrain bundle (MFB) lesion model of PD in rats. VEGF administration prevented the loss of motor functions induced by 6-OHDA as determined by behavior analysis. Similarly, VEGF inhibited the 6-OHDA mediated loss of DA neurons in Substantia Nigra Pars Compacta (SNPc) as well as DA nerve fibers in striatum as determined by TH immunostaining. In addition, PEI-PLL mediated VEGF gene delivery also prevented apoptosis and microglial activation in PD rat models. Together, these results clearly demonstrated the beneficial effects of PEI-PLL mediated VEGF gene delivery on dopaminergic system in both cell culture and animal models of PD. In this report, we exploited the potential of PEI-PLL to deliver VEGF gene for the potential therapeutic treatment of PD by using both cell culture and animal models of PD. To the best of our knowledge, this is the first report describing the use of novel polymeric gene carriers for the delivery of VEGF gene

Countercurrent Air-Water Flow in a Scale-Down Model of a Pressurizer Surge Line

Directory of Open Access Journals (Sweden)

Takashi Futatsugi

2012-01-01

Full Text Available Steam generated in a reactor core and water condensed in a pressurizer form a countercurrent flow in a surge line between a hot leg and the pressurizer during reflux cooling. Characteristics of countercurrent flow limitation (CCFL in a 1/10-scale model of the surge line were measured using air and water at atmospheric pressure and room temperature. The experimental results show that CCFL takes place at three different locations, that is, at the upper junction, in the surge line, and at the lower junction, and its characteristics are governed by the most dominating flow limitation among the three. Effects of inclination angle and elbows of the surge line on CCFL characteristics were also investigated experimentally. The effects of inclination angle on CCFL depend on the flow direction, that is, the effect is large for the nearly horizontal flow and small for the vertical flow at the upper junction. The presence of elbows increases the flow limitation in the surge line, whereas the flow limitations at the upper and lower junctions do not depend on the presence of elbows.

Parkinson’s Disease and Cryptogenic Epilepsy

Directory of Open Access Journals (Sweden)

Andre Y. Son

2016-01-01

Full Text Available Epilepsy is an uncommon comorbidity of Parkinson’s disease (PD and has been considered not directly associated with PD. We present five patients (3 men and 2 women; ages 49–85 who had concomitant PD and cryptogenic epilepsy. Although rare, epilepsy can coexist with PD and their coexistence may influence the progression of PD. While this may be a chance association, an evolving understanding of the neurophysiological basis of either disease may suggest a mechanistic association.

PD1/PD1L pathway, HLA-G and T regulatory cells as new markers of immunosuppression in cancers

Directory of Open Access Journals (Sweden)

Paulina Własiuk

2016-10-01

Full Text Available The appropriate function of the immune system depends on the effective regulation of the immune response on multiple levels. The key element of an effective immune response to antigenic stimulation is maintaining a homeostasis between activation and inhibitory function of immunocompetent cells and molecules. In pathological conditions such as chronic infections, autoimmune diseases or cancer there are significant alterations, and prevalence of signals of one type over another. Main markers of these dysfunctions are altered expressions of molecules, such as programmed death-1 (PD-1, Human Leukocyte Antigen G (HLA-G, or changed percentages of T regulatory cells (Treg. These indicators of immune system dysfunction may contribute to disease progression, but also could represent good targets for treatment. Interestingly, in recent years there are many new, interesting reports which showed that the role of PD-1, HLA-G or Treg is ambiguous and not always their higher expression or frequency lead to the progression of disease. Recent studies have shown that Treg can suppress bacteria-driven inflammation which promotes carcinogenesis and thus protect the host from cancer development. Moreover, proliferation of hematological tumor cells expressing ILT-2 receptor can be inhibited by HLA-G, in contrast to solid tumors where HLA-G favors tumor escape. In this paper we present characteristics of expressions of PD-1 and its ligands, HLA-G, and frequency of Treg cells in a variety of physiological and pathological conditions associated with chronic infections, autoimmune diseases and cancer. The understanding of the complex interactions between the functional elements of immune system is essential for a detailed characteristics of the mechanisms leading to the development of diseases and identification of more effective targeted therapies.

Gender differences in Parkinson's disease

NARCIS (Netherlands)

Haaxma, Charlotte A.; Bloem, Bastiaan R.; Borm, George F.; Oyen, Wim J. G.; Leenders, Klaus L.; Eshuis, Silvia; Booij, Jan; Dluzen, Dean E.; Horstink, Martin W. I. M.

Objective: To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD). Methods: We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists ( disease duration Results: Age at onset

Gender differences in Parkinson's disease.

NARCIS (Netherlands)

Haaxma, C.A.; Bloem, B.R.; Borm, G.F.; Oyen, W.J.G.; Leenders, K.L.; Eshuis, S.; Booij, J.; Dluzen, D.E.; Horstink, M.W.I.M.

2007-01-01

OBJECTIVE: To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD). METHODS: We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists (disease duration < or = 10 years). We

Gender differences in Parkinson's disease

NARCIS (Netherlands)

Haaxma, Charlotte A.; Bloem, Bastiaan R.; Borm, George F.; Oyen, Wim J. G.; Leenders, Klaus L.; Eshuis, Silvia; Booij, Jan; Dluzen, Dean E.; Horstink, Martin W. I. M.

2007-01-01

OBJECTIVE: To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD). METHODS: We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists (disease duration < or = 10 years). We

Experimental Study on Active Control of Surge in a Centrifugal Compression System

Directory of Open Access Journals (Sweden)

Nie Chaoqun

2000-01-01

Full Text Available An experimental study has been carried out on the active control of surge in a centrifugal compression system. With a computerized on-line control scheme, the surge phenomenon is suppressed and the stable operating range of the system is extended. In order to design the active control scheme and choose the desired parameters of the control system inputs, special emphases have been placed on the development of surge inception and the nonlinear interaction between the system and the actuator. By use of the method designed in the present work, the results of active control onsurge have been demonstrated for the different B parameters, different prescribed criteria and different control frequencies.

Cortisol Interferes with the Estradiol-Induced Surge of Luteinizing Hormone in the Ewe1

Science.gov (United States)

Wagenmaker, Elizabeth R.; Breen, Kellie M.; Oakley, Amy E.; Pierce, Bree N.; Tilbrook, Alan J.; Turner, Anne I.; Karsch, Fred J.

2008-01-01

Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge. Ovariectomized sheep were treated sequentially with progesterone and estradiol to create artificial estrous cycles. Cortisol or vehicle (saline) was infused from 2 h before the estradiol stimulus through the time of the anticipated LH surge in the artificial follicular phase of two successive cycles. The plasma cortisol increment produced by infusion was ∼1.5 times greater than maximal concentrations seen during infusion of endotoxin, which is a model of immune/inflammatory stress. In experiment 1, half of the ewes received vehicle in the first cycle and cortisol in the second; the others were treated in reverse order. All ewes responded with an LH surge. Cortisol delayed the LH surge and reduced its amplitude, but both effects were observed only in the second cycle. Experiment 2 was modified to provide better control for a cycle effect. Four treatment sequences were tested (cycle 1-cycle 2): vehicle-vehicle, cortisol-cortisol, vehicle-cortisol, cortisol-vehicle. Again, cortisol delayed but did not block the LH surge, and this delay occurred in both cycles. Thus, an elevation in plasma cortisol can interfere with the positive feedback action of estradiol by delaying and attenuating the LH surge. PMID:19056703

Development of Storm Surge Hazard Maps and Advisory System for the Philippines

Science.gov (United States)

Santiago, Joy; Mahar Francisco Lagymay, Alfredo; Caro, Carl Vincent; Suarez, John Kenneth; Tablazon, Judd; Dasallas, Lea; Garnet Goting, Prince

2016-04-01

The Philippines, located in the most active region of cyclogenesis in the world, experiences an average of 20 tropical cyclones annually. Strong winds brought by tropical cyclones, among other factors, cause storm surges that inundate the coastal areas of the country. As an archipelago with the fourth longest coastline in the world, the country is expose to the threats of storm surges. This was manifested by Typhoon Haiyan on 8 November 2013, which devastated the country and left 6,293 deaths and approximately USD 2 billion worth of damages. To prevent such disaster from happening again, the Nationwide Operational Assessment of Hazards (Project NOAH) developed a Storm Surge Advisory (SSA) that aims to warn communities in coastal areas against impending floods due to storm surges. The Japan Meteorological Agency storm surge model was used to simulate 721 tropical cyclones that entered the Philippine Area of Responsibility from 1951-2013. The resulting storm surge time series from the simulations were added to the maximum tide levels from the WXTide software for the 4,996 observation points placed nearshore in the entire country. The storm tide levels were categorized into four groups based on their peak height to create the SSA - SSA 1 (0.01m to 2m), SSA 2 (2.01m to 3m), SSA 3 (3.01m to 4m), and SSA 4 (4m and above). The time series for each advisory level was used in inundation modelling using FLO-2D, a two-dimensional flood modeling software that uses continuity and dynamic wave momentum equation. The model produced probable extent, depth of inundation, and hazard level for each advisory level. The SSA hazard maps are used as reference to warn communities that are likely to be affected by storm surges. Advisory is released 24 hours in advance and is updated every six hours in the Project NOAH website. It is also being utilized in the pre-disaster risk assessment of the national government agencies and local government units in designing appropriate response to

Familial aggregation of Parkinson’s disease and coaggregation with neuropsychiatric diseases: a population-based cohort study

Directory of Open Access Journals (Sweden)

Liu FC

2018-05-01

Full Text Available Fu-Chao Liu,1,2,* Huan-Tang Lin,1,2,* Chang-Fu Kuo,2–4 Mei-Yun Hsieh,4 Lai-Chu See,3,5,6 Huang-Ping Yu1,2,7 1Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2College of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Office for Big Data Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 6Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; 7Department of Anesthesiology, Xiamen Changgung Hospital, Xiamen, China *These authors contributed equally to this work Background: Individuals with a family history of Parkinson’s disease (PD appear to have a higher risk of developing PD and other neuropsychiatric diseases. However, estimates of the relative risks (RRs of PD and the roles of genetic and environmental factors in PD susceptibility are unclear. The aim of this study was to examine familial aggregation and genetic contributions to PD and the RRs of other neuropsychiatric diseases in relatives of PD patients. Methods: In this population-based family cohort study, the records of all individuals actively registered in the Taiwan National Health Insurance Research Database in 2015 were queried (N=24,349,599. In total, 149,187 individuals with a PD-affected parent, 3,698 with an affected offspring, 3,495 with an affected sibling, and 15 with an affected twin were identified. Diagnoses of PD were ascertained between January 1, 1999, and December 31, 2015. The prevalence and RRs of PD and other neuropsychiatric diseases in individuals with first-degree relatives with PD, as well as the contributions of heritability and environmental factors to PD susceptibility were investigated. Results: The prevalence of PD was 0.46% in the general population and 0.52% in individuals with

Cell transplantation for Parkinson's disease

Institute of Scientific and Technical Information of China (English)

Jia Liu; Hongyun Huang

2006-01-01

OBJECTIVE: The motor symptoms of Parkinson's disease (PD) can be improved by cell transplantation,which has caught general attention from the field of the therapy for PD recently. In this paper, we summarize the cell-based therapy for PD.DATA SOURCES: A search for English literature related to the cellular transplantation of PD from January 1979to July 2006 was conducted in Medline with the key words of "Parkinson's disease, cell transplantation,embryonic stem cells, neural stem cells".STUDY SELECTTON: Data were checked in the first trial, and literatures about PD and cell transplantation were selected. Inclusive criteria: ① PD; ② Cell transplantation. Exclusive criteria: repetitive researches.DATA EXTRACTTON: A total of 100 papers related to cellular transplant and PD were collected and 41literatures were in accordance with the inclusive criteria.DATA SYNTHESIS: PD is a neural degeneration disease that threatens the health of the aged people, and most traditional therapeusis cannot delay its pathological proceeding. Cell transplantation is becoming popular as a new therapeutic tool, and the cells used to transplant mainly included dopamine-secreting cells, fetal ventral mesencephalic cells, embryonic stem cells and neural stem cells up to now. Animal experiment and clinical test demonstrate that cell transplantation can relieve the motor symptoms of Parkinson's disease obviously, but there are some problems need to be solved.CONCLUSTON: Cell transplantation has visible therapeutic efficacy on PD. Following the improvement of technique, and we have enough cause to credit that cell therapy may cure PD in the future.

X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria

OpenAIRE

Guindo, Aldiouma; Fairhurst, Rick M; Doumbo, Ogobara K; Wellems, Thomas E; Diallo, Dapa A

2007-01-01

Editors' Summary Background. “Favism” is a condition that results from a deficiency in an enzyme called glucose-6-phosphate dehydrogenase (G6PD), and this disorder is thought to be the commonest enzyme-deficiency disease worldwide. The disease is named favism after the Italian word for broad beans (fava), which cause a classic reaction when eaten by people with G6PD deficiency. The G6PD enzyme is particularly important in red blood cells, where it protects against damage that can be caused by...

Parameter sensitivity and uncertainty analysis for a storm surge and wave model

Directory of Open Access Journals (Sweden)

L. A. Bastidas

2016-09-01

Full Text Available Development and simulation of synthetic hurricane tracks is a common methodology used to estimate hurricane hazards in the absence of empirical coastal surge and wave observations. Such methods typically rely on numerical models to translate stochastically generated hurricane wind and pressure forcing into coastal surge and wave estimates. The model output uncertainty associated with selection of appropriate model parameters must therefore be addressed. The computational overburden of probabilistic surge hazard estimates is exacerbated by the high dimensionality of numerical surge and wave models. We present a model parameter sensitivity analysis of the Delft3D model for the simulation of hazards posed by Hurricane Bob (1991 utilizing three theoretical wind distributions (NWS23, modified Rankine, and Holland. The sensitive model parameters (of 11 total considered include wind drag, the depth-induced breaking γB, and the bottom roughness. Several parameters show no sensitivity (threshold depth, eddy viscosity, wave triad parameters, and depth-induced breaking αB and can therefore be excluded to reduce the computational overburden of probabilistic surge hazard estimates. The sensitive model parameters also demonstrate a large number of interactions between parameters and a nonlinear model response. While model outputs showed sensitivity to several parameters, the ability of these parameters to act as tuning parameters for calibration is somewhat limited as proper model calibration is strongly reliant on accurate wind and pressure forcing data. A comparison of the model performance with forcings from the different wind models is also presented.

Brief communication: The Khurdopin glacier surge revisited - extreme flow velocities and formation of a dammed lake in 2017

Science.gov (United States)

Steiner, Jakob F.; Kraaijenbrink, Philip D. A.; Jiduc, Sergiu G.; Immerzeel, Walter W.

2018-01-01

Glacier surges occur regularly in the Karakoram, but the driving mechanisms, their frequency and its relation to a changing climate remain unclear. In this study, we use digital elevation models and Landsat imagery in combination with high-resolution imagery from the Planet satellite constellation to quantify surface elevation changes and flow velocities during a glacier surge of the Khurdopin Glacier in 2017. Results reveal that an accumulation of ice volume above a clearly defined steep section of the glacier tongue since the last surge in 1999 eventually led to a rapid surge in May 2017 peaking with velocities above 5000 m a-1, which were among the fastest rates globally for a mountain glacier. Our data reveal that velocities on the lower tongue increase steadily during a 4-year build-up phase prior to the actual surge only to then rapidly peak and decrease again within a few months, which confirms earlier observations with a higher frequency of available velocity data. The surge return period between the reported surges remains relatively constant at ca. 20 years. We show the potential of a combination of repeat Planet and ASTER imagery to (a) capture peak surge velocities that are easily missed by less frequent Landsat imagery, (b) observe surface changes that indicate potential drivers of a surge and (c) monitor hazards associated with a surge. At Khurdopin specifically, we observe that the surging glacier blocks the river in the valley and causes a lake to form, which may grow in subsequent years and could pose threats to downstream settlements and infrastructure in the case of a sudden breach.

The analysis of dependence between extreme rainfall and storm surge in the coastal zone

Science.gov (United States)

Zheng, F.; Westra, S.

2012-12-01

Flooding in coastal catchments can be caused by runoff generated by an extreme rainfall event, elevated sea levels due to an extreme storm surge event, or the combination of both processes occurring simultaneously or in close succession. Dependence in extreme rainfall and storm surge arises because common meteorological forcings often drive both variables; for example, cyclonic systems may produce extreme rainfall, strong onshore winds and an inverse barometric effect simultaneously, which the former factor influencing catchment discharge and the latter two factors influencing storm surge. Nevertheless there is also the possibility that only one of the variables is extreme at any given time, so that the dependence between rainfall and storm surge is not perfect. Quantification of the strength of dependence between these processes is critical in evaluating the magnitude of flood risk in the coastal zone. This may become more important in the future as the majority of the coastal areas are threatened by the sea level rise due to the climate change. This research uses the most comprehensive record of rainfall and storm surge along the coastline of Australia collected to-date to investigate the strength of dependence between the extreme rainfall and storm surge along the Australia coastline. A bivariate logistic threshold-excess model was employed to this end to carry out the dependence analysis. The strength of the estimated dependence is then evaluated as a function of several factors including: the distance between the tidal gauge and the rain gauge; the lag between the extreme precipitation event and extreme surge event; and the duration of the maximum storm burst. The results show that the dependence between the extreme rainfall and storm surge along the Australia coastline is statistically significant, although some locations clearly exhibit stronger dependence than others. We hypothesize that this is due to a combination of large-scale meteorological effects as

Investigation of surge protective devices operation of a wind generator

International Nuclear Information System (INIS)

Dimitrov, D.; Vasileva, M.

2008-01-01

The interest to the investments in a wind energetics increases in the last years. The wind energetics is the fastest developing direction in the energetics in global scale. The wind energy is more attractive because its prices are lower in comparison of the other technologies for generating energy. The right choice of the surge protective devices has the important meaning on building and exploitation of the wind generators. The aim of this paper is investigation of the surge protective devices operation when they are installation to a wind generator. (authors)

Three-Dimensional Numerical Analysis of Compound Lining in Complex Underground Surge-Shaft Structure

Directory of Open Access Journals (Sweden)

Juntao Chen

2015-01-01

Full Text Available The mechanical behavior of lining structure of deep-embedded cylinder surge shaft with multifork tunnel is analyzed using three-dimensional nonlinear FEM. With the elastic-plastic constitutive relations of rock mass imported and the implicit bolt element and distributed concrete cracking model adopted, a computing method of complex surge shaft is presented for the simulation of underground excavations and concrete lining cracks. In order to reflect the interaction and initial gap between rock mass and concrete lining, a three-dimensional nonlinear interface element is adopted, which can take into account both the normal and tangential characteristics. By an actual engineering computation, the distortion characteristics and stress distribution rules of the dimensional multifork surge-shaft lining structure under different behavior are revealed. The results verify the rationality and feasibility of this computation model and method and provide a new idea and reference for the complex surge-shaft design and construction.

Storm Surge Modeling of Typhoon Haiyan at the Naval Oceanographic Office Using Delft3D

Science.gov (United States)

Gilligan, M. J.; Lovering, J. L.

2016-02-01

The Naval Oceanographic Office provides estimates of the rise in sea level along the coast due to storm surge associated with tropical cyclones, typhoons, and hurricanes. Storm surge modeling and prediction helps the US Navy by providing a threat assessment tool to help protect Navy assets and provide support for humanitarian assistance/disaster relief efforts. Recent advancements in our modeling capabilities include the use of the Delft3D modeling suite as part of a Naval Research Laboratory (NRL) developed Coastal Surge Inundation Prediction System (CSIPS). Model simulations were performed on Typhoon Haiyan, which made landfall in the Philippines in November 2013. Comparisons of model simulations using forecast and hindcast track data highlight the importance of accurate storm track information for storm surge predictions. Model runs using the forecast track prediction and hindcast track information give maximum storm surge elevations of 4 meters and 6.1 meters, respectively. Model results for the hindcast simulation were compared with data published by the JSCE-PICE Joint survey for locations in San Pedro Bay (SPB) and on the Eastern Samar Peninsula (ESP). In SPB, where wind-induced set-up predominates, the model run using the forecast track predicted surge within 2 meters in 38% of survey locations and within 3 meters in 59% of the locations. When the hindcast track was used, the model predicted within 2 meters in 77% of the locations and within 3 meters in 95% of the locations. The model was unable to predict the high surge reported along the ESP produced by infragravity wave-induced set-up, which is not simulated in the model. Additional modeling capabilities incorporating infragravity waves are required to predict storm surge accurately along open coasts with steep bathymetric slopes, such as those seen in island arcs.

The Effect of Coastal Development on Storm Surge Flooding in Biscayne Bay, Florida, USA (Invited)

Science.gov (United States)

Zhang, K.; Liu, H.; Li, Y.

2013-12-01

Barrier islands and associated bays along the Atlantic and Gulf Coasts are a favorite place for both living and visiting. Many of them are vulnerable to storm surge flooding because of low elevations and constantly being subjected to the impacts of storms. The population increase and urban development along the barrier coast have altered the shoreline configuration, resulting in a dramatic change in the coastal flooding pattern in some areas. Here we present such a case based on numerical simulations of storm surge flooding caused by the1926 hurricane in the densely populated area surrounding Biscayne Bay in Miami, Florida. The construction of harbor and navigation channels, and the development of real estate and the roads connecting islands along Biscayne Bay have changed the geometry of Biscayne Bay since 1910s. Storm surge simulations show that the Port of Miami and Dodge Island constructed by human after 1950 play an important role in changing storm surge inundation pattern along Biscayne Bay. Dodge Island enhances storm surge and increases inundation in the area south of the island, especially at the mouth of Miami River (Downtown of Miami), and reduces storm surge flooding in the area north of the island, especially in Miami Beach. If the Hurricane Miami of 1926 happened today, the flooding area would be reduced by 55% and 20% in the Miami Beach and North Miami areas, respectively. Consequently, it would prevent 400 million of property and 10 thousand people from surge flooding according to 2010 U.S census and 2007 property tax data. Meanwhile, storm water would penetrate further inland south of Dodge Island and increase the flooding area by 25% in the Miami River and Downtown Miami areas. As a result, 200 million of property and five thousand people would be impacted by storm surge.

Prevalence and characteristics of dementia in Parkinson disease

DEFF Research Database (Denmark)

Aarsland, Dag; Andersen, Kjeld; Larsen, Jan P

2003-01-01

Few longitudinal studies of dementia in Parkinson disease (PD) have been reported, and the proportion of patients with PD who eventually develop dementia is unknown.......Few longitudinal studies of dementia in Parkinson disease (PD) have been reported, and the proportion of patients with PD who eventually develop dementia is unknown....

Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.

Science.gov (United States)

Nagatsu, Toshiharu; Nagatsu, Ikuko

2016-11-01

Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline. Since deficiencies of dopamine and noradrenaline in the brain stem, caused by neurodegeneration of dopamine and noradrenaline neurons, are mainly related to non-motor and motor symptoms of Parkinson's disease (PD), we have studied human CA-synthesizing enzymes [TH; BH4-related enzymes, especially GTP-cyclohydrolase I (GCH1); aromatic L-amino acid decarboxylase (AADC); dopamine β-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT)] and their genes in relation to PD in postmortem brains from PD patients, patients with CA-related genetic diseases, mice with genetically engineered CA neurons, and animal models of PD. We purified all human CA-synthesizing enzymes, produced their antibodies for immunohistochemistry and immunoassay, and cloned all human genes, especially the human TH gene and the human gene for GCH1, which synthesizes BH4 as a cofactor of TH. This review discusses the historical overview of TH, BH4-, and other CA-related enzymes and their genes in relation to the pathophysiology of PD, the development of drugs, such as L-DOPA, and future prospects for drug and gene therapy for PD, especially the potential of induced pluripotent stem (iPS) cells.

The pathophysiology of Peyronie's disease.

Science.gov (United States)

El-Sakka, Ahmed I; Salabas, Emre; Dinçer, Murat; Kadioglu, Ates

2013-09-01

To review the contemporary knowledge of the pathophysiology of Peyronie's disease (PD). Medline was searched for papers published in English from 2000 to March 2013, using the keywords 'Peyronie's disease' and 'pathophysiology'. More than 300 relevant articles were identified for the purpose of this review. Unfortunately only a few studies had a high level of evidence, and the remaining studies were not controlled in their design. Many theories have been proposed to explain the cause of PD, but the true pathogenesis of PD remains an enigma. Identifying particular growth factors and the specific genes responsible for the induction of PD have been the ultimate goal of research over the past several decades. This would provide the means to devise a possible gene therapy for this devastating condition. We discuss present controversies and new discoveries related to the pathophysiology of this condition. PD is one of the most puzzling diseases in urology. The pathogenesis remains uncertain and there is still controversy about the best management. The pathogenesis of PD has been explored in animal models, cell cultures and clinical trials, but the results have led to further questions. New research on the aetiology and pathogenesis of PD is needed, and which will hopefully improve the understanding and management for patients with this frustrating disease.

Effect of layout on surge line thermal stratification

International Nuclear Information System (INIS)

Lai Jianyong; Huang Wei

2011-01-01

In order to analyze and evaluate the effect of layout on the thermal stratification for PWR Pressurizer surge line, numerical simulation by Computational Fluid Dynamics (CFD) method is taken on 6 kinds of layout improvement with 2 improvement schemes, i.e., increasing the obliquity of quasi horizontal section and adding a vertical pipe between the quasi horizontal section and next elbow, and the maximum temperature differences of quasi horizontal section of surge line of various layouts under different flowrate are obtained. The comparison shows that, the increasing of the obliquity of quasi horizontal section can mitigate the thermal stratification phenomena but can not eliminate this phenomena, while the adding of a vertical pipe between the quasi horizontal section and next elbow can effectively mitigate and eliminate the thermal stratification phenomena. (authors)

Evidence for Anti-Pseudogymnoascus destructans (Pd Activity of Propolis

Directory of Open Access Journals (Sweden)

Soumya Ghosh

2017-12-01

Full Text Available White-nose syndrome (WNS in bats, caused by Pseudogymnoascus destructans (Pd, is a cutaneous infection that has devastated North American bat populations since 2007. At present, there is no effective method for controlling this disease. Here, we evaluated the effect of propolis against Pd in vitro. Using Sabouraud dextrose agar (SDA medium, approximately 1.7 × 107 conidia spores of the Pd strain M3906-2/mL were spread on each plate and grown to form a consistent lawn. A Kirby–Bauer disk diffusion assay was employed using different concentrations of propolis (1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25%, in plates incubated at 8 °C and 15 °C. At 8 °C and 15 °C, as the concentration of propolis increased, there was an increasing zone of inhibition (ZOI, reaching the highest degree at 10% and 25% concentrations, respectively. A germule suppression assay showed a similar effect on Pd conidia germination. A MALDI-TOF-MS analysis of propolis revealed multiple constituents with a potential anti-Pd activity, including cinnamic acid, p-coumaric acid, and dihydrochalcones, which could be further tested for their individual effects. Our study suggests that propolis or its individual constituents might be suitable products against Pd.

Evidence for Anti-Pseudogymnoascus destructans (Pd) Activity of Propolis.

Science.gov (United States)

Ghosh, Soumya; McArthur, Robyn; Guo, Zhi Chao; McKerchar, Rory; Donkor, Kingsley; Xu, Jianping; Cheeptham, Naowarat

2017-12-21

White-nose syndrome (WNS) in bats, caused by Pseudogymnoascus destructans ( Pd ), is a cutaneous infection that has devastated North American bat populations since 2007. At present, there is no effective method for controlling this disease. Here, we evaluated the effect of propolis against Pd in vitro. Using Sabouraud dextrose agar (SDA) medium, approximately 1.7 × 10⁷ conidia spores of the Pd strain M3906-2/mL were spread on each plate and grown to form a consistent lawn. A Kirby-Bauer disk diffusion assay was employed using different concentrations of propolis (1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25%), in plates incubated at 8 °C and 15 °C. At 8 °C and 15 °C, as the concentration of propolis increased, there was an increasing zone of inhibition (ZOI), reaching the highest degree at 10% and 25% concentrations, respectively. A germule suppression assay showed a similar effect on Pd conidia germination. A MALDI-TOF-MS analysis of propolis revealed multiple constituents with a potential anti- Pd activity, including cinnamic acid, p-coumaric acid, and dihydrochalcones, which could be further tested for their individual effects. Our study suggests that propolis or its individual constituents might be suitable products against Pd .

Modeling and simulation of storm surge on Staten Island to understand inundation mitigation strategies

Science.gov (United States)

Kress, Michael E.; Benimoff, Alan I.; Fritz, William J.; Thatcher, Cindy A.; Blanton, Brian O.; Dzedzits, Eugene

2016-01-01

Hurricane Sandy made landfall on October 29, 2012, near Brigantine, New Jersey, and had a transformative impact on Staten Island and the New York Metropolitan area. Of the 43 New York City fatalities, 23 occurred on Staten Island. The borough, with a population of approximately 500,000, experienced some of the most devastating impacts of the storm. Since Hurricane Sandy, protective dunes have been constructed on the southeast shore of Staten Island. ADCIRC+SWAN model simulations run on The City University of New York's Cray XE6M, housed at the College of Staten Island, using updated topographic data show that the coast of Staten Island is still susceptible to tidal surge similar to those generated by Hurricane Sandy. Sandy hindcast simulations of storm surges focusing on Staten Island are in good agreement with observed storm tide measurements. Model results calculated from fine-scaled and coarse-scaled computational grids demonstrate that finer grids better resolve small differences in the topography of critical hydraulic control structures, which affect storm surge inundation levels. The storm surge simulations, based on post-storm topography obtained from high-resolution lidar, provide much-needed information to understand Staten Island's changing vulnerability to storm surge inundation. The results of fine-scale storm surge simulations can be used to inform efforts to improve resiliency to future storms. For example, protective barriers contain planned gaps in the dunes to provide for beach access that may inadvertently increase the vulnerability of the area.

Psychogenic and neural visual-cue response in PD dopamine dysregulation syndrome.

Science.gov (United States)

Loane, Clare; Wu, Kit; O'Sullivan, Sean S; Lawrence, Andrew D; Woodhead, Zoe; Lees, Andrew J; Piccini, Paola; Politis, Marios

2015-11-01

Dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) patients refers to the compulsive use of dopaminergic replacement therapy and has serious psycho-social consequences. Mechanisms underlying DDS are not clear although has been linked to dysfunctional brain reward networks. With fMRI, we investigate behavioral and neural response to drug-cues in six PD DDS patients and 12 PD control patients in both the ON and OFF medication state. Behavioral measures of liking, wanting and subjectively 'feeling ON medication' were also collected. Behaviorally, PD DDS patients feel less ON and want their drugs more at baseline compared to PD controls. Following drug-cue exposure, PD DDS patients feel significantly more ON medication, which correlates with significant increases in reward related regions. The results demonstrate that exposure to drug-cues increases the subjective feeling of being 'ON' medication which corresponds to dysfunctional activation in reward related regions in PD DDS patients. These findings should be extended in future studies. Visual stimuli being sufficient to elicit behavioral response through neuroadaptations could have direct implications to the management of addictive behavior. Copyright © 2015 Elsevier Ltd. All rights reserved.

Elevated Serum Pesticide Levels and Risk of Parkinson Disease

Science.gov (United States)

Richardson, Jason R.; Shalat, Stuart L.; Buckley, Brian; Winnik, Bozena; O’Suilleabhain, Padraig; Diaz-Arrastia, Ramon; Reisch, Joan; German, Dwight C.

2012-01-01

Background Exposure to pesticides has been reported to increase the risk of Parkinson disease (PD), but identification of the specific pesticides is lacking. Three studies have found elevated levels of organochlorine pesticides in postmortem PD brains. Objective To determine whether elevated levels of organochlorine pesticides are present in the serum of patients with PD. Design Case-control study. Setting An academic medical center. Participants Fifty patients with PD, 43 controls, and 20 patients with Alzheimer disease. Main Outcome Measures Levels of 16 organochlorine pesticides in serum samples. Results β-Hexachlorocyclohexane (β-HCH) was more often detectable in patients with PD (76%) compared with controls (40%) and patients with Alzheimer disease (30%). The median level of β-HCH was higher in patients with PD compared with controls and patients with Alzheimer disease. There were no marked differences in detection between controls and patients with PD concerning any of the other 15 organochlorine pesticides. Finally, we observed a significant odds ratio for the presence of β-HCH in serum to predict a diagnosis of PD vs control (odds ratio, 4.39; 95% confidence interval, 1.67–11.6) and PD vs Alzheimer disease (odds ratio, 5.20), which provides further evidence for the apparent association between serum β-HCH and PD. Conclusions These data suggest that β-HCH is associated with a diagnosis of PD. Further research is warranted regarding the potential role of β-HCH as a etiologic agent for some cases of PD. PMID:19597089

Rapid wave and storm surge warning system for tropical cyclones in Mexico

Science.gov (United States)

Appendini, C. M.; Rosengaus, M.; Meza, R.; Camacho, V.

2015-12-01

The National Hurricane Center (NHC) in Miami, is responsible for the forecast of tropical cyclones in the North Atlantic and Eastern North Pacific basins. As such, Mexico, Central America and Caribbean countries depend on the information issued by the NHC related to the characteristics of a particular tropical cyclone and associated watch and warning areas. Despite waves and storm surge are important hazards for marine operations and coastal dwellings, their forecast is not part of the NHC responsibilities. This work presents a rapid wave and storm surge warning system based on 3100 synthetic tropical cyclones doing landfall in Mexico. Hydrodynamic and wave models were driven by the synthetic events to create a robust database composed of maximum envelops of wind speed, significant wave height and storm surge for each event. The results were incorporated into a forecast system that uses the NHC advisory to locate the synthetic events passing inside specified radiuses for the present and forecast position of the real event. Using limited computer resources, the system displays the information meeting the search criteria, and the forecaster can select specific events to generate the desired hazard map (i.e. wind, waves, and storm surge) based on the maximum envelop maps. This system was developed in a limited time frame to be operational in 2015 by the National Hurricane and Severe Storms Unit of the Mexican National Weather Service, and represents a pilot project for other countries in the region not covered by detailed storm surge and waves forecasts.

Flow in sodium loop surge tank

International Nuclear Information System (INIS)

Matal, O.; Martoch, J.

1977-01-01

The alternate liquid flow, the condition of vortex formation, gas entrainment in the discharge and the liquid level characteristics are studied using the models of the vertical and horizontal surge tanks of a sodium circuit with pump and heat exchangers. The conditions for vortex formation are more favourable in the vertical cylindrical tank than in the horizontal tank. The size of the vortex produced in the tank is affected by the initial speed circulation, due as a rule to an unsuitable inlet design. The proposed design considers an inlet below the sodium level using capped perforated pipes. Vortex formation, gas transport to the discharge pipe and turbulences of the liquid in the tank may be prevented by dividing the tank to the discharge and the inlet areas using perforated partitions, and by inserting the discharge cylinder above the discharge pipe outflow. The liquid level in the tank may be calmed by screens or by perforated plates. The adaptation of the surge tank of the sodium circuit will probably eliminate vortex formation and the entrainment of cover gas into the discharge piping and the sodium circuit under nominal conditions. (J.B.)

Parkinson’s disease managing reversible neurodegeneration

Science.gov (United States)

Hinz, Marty; Stein, Alvin; Cole, Ted; McDougall, Beth; Westaway, Mark

2016-01-01

Traditionally, the Parkinson’s disease (PD) symptom course has been classified as an irreversible progressive neurodegenerative disease. This paper documents 29 PD and treatment-induced systemic depletion etiologies which cause and/or exacerbate the seven novel primary relative nutritional deficiencies associated with PD. These reversible relative nutritional deficiencies (RNDs) may facilitate and accelerate irreversible progressive neurodegeneration, while other reversible RNDs may induce previously undocumented reversible pseudo-neurodegeneration that is hiding in plain sight since the symptoms are identical to the symptoms being experienced by the PD patient. Documented herein is a novel nutritional approach for reversible processes management which may slow or halt irreversible progressive neurodegenerative disease and correct reversible RNDs whose symptoms are identical to the patient’s PD symptoms. PMID:27103805

Data Assimilation within the Advanced Circulation (ADCIRC) Modeling Framework for Hurricane Storm Surge Forecasting

KAUST Repository

Butler, T.; Altaf, Muhammad; Dawson, C.; Hoteit, Ibrahim; Luo, X.; Mayo, T.

2012-01-01

levels, and wave heights—during these extreme events. This type of data, if available in real time, could be used in a data assimilation framework to improve hurricane storm surge forecasts. In this paper a data assimilation methodology for storm surge

Inflammatory bowel disease increases the risk of Parkinson's disease

DEFF Research Database (Denmark)

Villumsen, Marie; Aznar, Susana; Pakkenberg, Bente

2018-01-01

OBJECTIVE: Intestinal inflammation has been suggested to play a role in development of Parkinson's disease (PD) and multiple system atrophy (MSA). To test the hypothesis that IBD is associated with risk of PD and MSA, we performed a nationwide population-based cohort study. DESIGN: The cohort...... patients with UC (HR=1.35; 95% CI 1.20 to 1.52) and not significantly different among patients with Crohn's disease (HR=1.12; 95% CI 0.89 to 1.40). CONCLUSIONS: This nationwide, unselected, cohort study shows a significant association between IBD and later occurrence of PD, which is consistent with recent...

Probabilistic storm surge inundation maps for Metro Manila based on Philippine public storm warning signals

Science.gov (United States)

Tablazon, J.; Caro, C. V.; Lagmay, A. M. F.; Briones, J. B. L.; Dasallas, L.; Lapidez, J. P.; Santiago, J.; Suarez, J. K.; Ladiero, C.; Gonzalo, L. A.; Mungcal, M. T. F.; Malano, V.

2015-03-01

A storm surge is the sudden rise of sea water over the astronomical tides, generated by an approaching storm. This event poses a major threat to the Philippine coastal areas, as manifested by Typhoon Haiyan on 8 November 2013. This hydro-meteorological hazard is one of the main reasons for the high number of casualties due to the typhoon, with 6300 deaths. It became evident that the need to develop a storm surge inundation map is of utmost importance. To develop these maps, the Nationwide Operational Assessment of Hazards under the Department of Science and Technology (DOST-Project NOAH) simulated historical tropical cyclones that entered the Philippine Area of Responsibility. The Japan Meteorological Agency storm surge model was used to simulate storm surge heights. The frequency distribution of the maximum storm surge heights was calculated using simulation results of tropical cyclones under a specific public storm warning signal (PSWS) that passed through a particular coastal area. This determines the storm surge height corresponding to a given probability of occurrence. The storm surge heights from the model were added to the maximum astronomical tide data from WXTide software. The team then created maps of inundation for a specific PSWS using the probability of exceedance derived from the frequency distribution. Buildings and other structures were assigned a probability of exceedance depending on their occupancy category, i.e., 1% probability of exceedance for critical facilities, 10% probability of exceedance for special occupancy structures, and 25% for standard occupancy and miscellaneous structures. The maps produced show the storm-surge-vulnerable areas in Metro Manila, illustrated by the flood depth of up to 4 m and extent of up to 6.5 km from the coastline. This information can help local government units in developing early warning systems, disaster preparedness and mitigation plans, vulnerability assessments, risk-sensitive land use plans, shoreline

Biomarker-driven phenotyping in Parkinson disease: a translational missing link in disease-modifying clinical trials

Science.gov (United States)

Espay, Alberto J.; Schwarzschild, Michael A.; Tanner, Caroline M.; Fernandez, Hubert H; Simon, David K.; Leverenz, James B.; Merola, Aristide; Chen-Plotkin, Alice; Brundin, Patrik; Kauffman, Marcelo A.; Erro, Roberto; Kieburtz, Karl; Woo, Daniel; Macklin, Eric A.; Standaert, David G.; Lang, Anthony E.

2016-01-01

Past clinical trials of putative neuroprotective therapies have targeted Parkinson disease (PD) as a single pathogenic disease entity. From an Oslerian clinico-pathologic perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach to PD: a single-mechanism therapy can affect most of those sharing the classic pathologic hallmark. From a systems-biology perspective, PD is a group of disorders that, while related by sharing the feature of nigral dopamine-neuron degeneration, exhibit unique genetic, biological and molecular abnormalities, which probably respond differentially to a given therapeutic approach, particularly for strategies aimed at neuroprotection. Under this model, only biomarker-defined, homogenous subtypes of PD are likely to respond optimally to therapies proven to affect the biological processes within each subtype. Therefore, we suggest that precision medicine applied to PD requires a reevaluation of the biomarker-discovery effort. This effort is currently centered on correlating biological measures to clinical features of PD and on identifying factors that predict whether various prodromal states will convert into the classical movement disorder. We suggest, instead, that subtyping of PD requires the reverse view, where abnormal biological signals (i.e., biomarkers) rather than clinical definitions are used to define disease phenotypes. Successful development of disease-modifying strategies will depend on how relevant the specific biological processes addressed by an intervention are to the pathogenetic mechanisms in the subgroup of targeted patients. This precision-medicine approach will likely yield smaller but well-defined subsets of PD amenable to successful neuroprotection. PMID:28233927

Coupled wave and surge modelling for the eastern Irish Sea and implications for model wind-stress

Science.gov (United States)

Brown, Jennifer M.; Wolf, Judith

2009-05-01

We revisit the surge of November 1977, a storm event which caused damage on the Sefton coast in NW England. A hindcast has been made with a coupled surge-tide-wave model, to investigate whether a wave-dependent surface drag is necessary for accurate surge prediction, and also if this can be represented by an optimised Charnock parameter. The Proudman Oceanographic Laboratory Coastal Modelling System-Wave Model (POLCOMS-WAM) has been used to model combined tides, surges, waves and wave-current interaction in the Irish Sea on a 1.85 km grid. This period has been previously thoroughly studied, e.g. Jones and Davies [Jones, J.E., Davies, A.M., 1998. Storm surge computations for the Irish Sea using a three-dimensional numerical model including wave-current interaction. Continental Shelf Research 18(2), 201-251] and we build upon this previous work to validate the POLCOMS-WAM model to test the accuracy of surge elevation predictions in the study area. A one-way nested approach has been set up from larger scale models to the Irish Sea model. It was demonstrated that (as expected) swell from the North Atlantic does not have a significant impact in the eastern Irish Sea. To capture the external surge generated outside of the Irish Sea a (1/9° by 1/6°) model extending beyond the continental shelf edge was run using the POLCOMS model for tide and surge. The model results were compared with tide gauge observations around the eastern Irish Sea. The model was tested with different wind-stress formulations including Smith and Banke [Smith, S.D., Banke, E.G., 1975. Variation of the surface drag coefficient with wind speed. Quarterly Journal of the Royal Meteorology Society, 101(429), 665-673] and Charnock [Charnock, H., 1955. Wind-stress on a water surface. Quarterly Journal of the Royal Meteorological Society, 81(350), 639-640]. In order to get a single parameterisation that works with wave-coupling, the wave-derived surface roughness length has been imposed in the surge model

Psychosis in Parkinson's Disease.

Science.gov (United States)

Ffytche, Dominic H; Aarsland, Dag

2017-01-01

Although illusions, hallucinations and delusions did not play a prominent role in James Parkinson's original clinical descriptions, the longitudinal view of disease progression he advocated has important lessons for the study of such symptoms today. A focus on longitudinal progression rather than individual symptoms led to the concept of PD psychosis-a spectrum of positive symptoms in Parkinson's disease. The publication of criteria for PD psychosis in 2007 helped unify the disparate set of symptoms, raising their profile and resulting in a rapid expansion of literature focussing on clinical aspects, mechanisms, and treatment. Here we review this literature and the evolving view of PD psychosis. Adding to previous evidence of a prospective risk for dementia and the move to supervised care, key recent developments include: recognition of prevalence increase with disease duration; a broadening of symptoms included in PD psychosis; better characterization of higher visual and cognitive dysfunction risk factors; structural, functional, and neurotransmitter imaging biomarker evidence; and approval of pimavanserin in the United States for the treatment of PD psychosis. The accumulating evidence raises novel questions and directions for future research that promise a better understanding of the clinical management of PD psychosis and its role as a biomarker for PD stage and progression. © 2017 Elsevier Inc. All rights reserved.

Development of high voltage surge limiting resistor for protection of HV multiplier of 3 MeV DC accelerator

International Nuclear Information System (INIS)

Dewangan, S.; Sharma, D.K.; Bakhtsingh, R.I.

2013-01-01

A 3MeV, 10mA DC electron beam accelerator is in commissioning stages at EBC, Kharghar, Navi Mumbai. The accelerating potential of -3MV is generated by a Parallel Coupled Voltage Multiplier (PCVM) scheme using 74 stages of HV rectifier stacks in the 6 kg/cm 2 SF6 gas environment. The HV surges of order of 600kV, 42kA, 10ns is estimated across the rectifier stacks during sparking in the multiplier column. To limit the surge current and protect the rectifier diodes, a non inductive thick film surge limiting resistor (SLR) and protective spark gap is designed and developed. The rectifier stacks with surge limiting resistors at both the ends and protective spark gap in parallel has been successfully tested in simulated surge condition at an impulse voltage of 212kVp, 150ns FWHM and surge energy of 200J, 10ms, 20kV at 6kg/cm 2 SF6 gas environment and found satisfactorily. Subsequently the HV multiplier was installed with this surge protection scheme and is being tested at 1.2 MeV level. This paper describes the design features and test results of the non-inductive surge limiting resistor. (author)

Passive seismic monitoring of the Bering Glacier during its last surge event

Science.gov (United States)

Zhan, Z.

2017-12-01

The physical causes behind glacier surges are still unclear. Numerous evidences suggest that they probably involve changes in glacier basal conditions, such as switch of basal water system from concentrated large tunnels to a distributed "layer" as "connected cavities". However, most remote sensing approaches can not penetrate to the base to monitor such changes continuously. Here we apply seismic interferometry using ambient noise to monitor glacier seismic structures, especially to detect possible signatures of the hypothesized high-pressure water "layer". As an example, we derive an 11-year long history of seismic structure of the Bering Glacier, Alaska, covering its latest surge event. We observe substantial drops of Rayleigh and Love wavespeeds across the glacier during the surge event, potentially caused by changes in crevasse density, glacier thickness, and basal conditions.

Parameter identification of ZnO surge arrester models based on genetic algorithms

Energy Technology Data Exchange (ETDEWEB)

Bayadi, Abdelhafid [Laboratoire d' Automatique de Setif, Departement d' Electrotechnique, Faculte des Sciences de l' Ingenieur, Universite Ferhat ABBAS de Setif, Route de Bejaia Setif 19000 (Algeria)

2008-07-15

The correct and adequate modelling of ZnO surge arresters characteristics is very important for insulation coordination studies and systems reliability. In this context many researchers addressed considerable efforts to the development of surge arresters models to reproduce the dynamic characteristics observed in their behaviour when subjected to fast front impulse currents. The difficulties with these models reside essentially in the calculation and the adjustment of their parameters. This paper proposes a new technique based on genetic algorithm to obtain the best possible series of parameter values of ZnO surge arresters models. The validity of the predicted parameters is then checked by comparing the predicted results with the experimental results available in the literature. Using the ATP-EMTP package, an application of the arrester model on network system studies is presented and discussed. (author)

Association between periodontal disease and non-communicable diseases

Science.gov (United States)

Lee, Jae-Hong; Oh, Jin-Young; Youk, Tae-Mi; Jeong, Seong-Nyum; Kim, Young-Taek; Choi, Seong-Ho

2017-01-01

Abstract The National Health Insurance Service–Health Examinee Cohort during 2002 to 2013 was used to investigate the associations between periodontal disease (PD) and the following non-communicable diseases (NCDs): hypertension, diabetes mellitus, osteoporosis, cerebral infarction, angina pectoris, myocardial infarction, and obesity. Univariate and multivariate logistic regression analyses adjusting for potential confounders during the follow-up period—including age, sex, household income, insurance status, residence area, health status, and comorbidities—were used to estimated odds ratios (ORs) with 95% confidence intervals (CIs) in order to assess the associations between PD and NCDs. We enrolled 200,026 patients with PD and 154,824 subjects with a healthy oral status. Statistically, significant associations were found between PD and the investigated NCDs except for cerebral and myocardial infarction after adjusting for sociodemographic and comorbidity factors (P periodontitis pathogenesis as a triggering and mediating mechanism. PMID:28658175

Into the Surge of Network-driven Innovation

DEFF Research Database (Denmark)

Østergaard, Claus Møller; Rosenstand, Claus Andreas Foss; Gertsen, Frank

2013-01-01

this is examined from the 1880’s up until today. The contribution of the paper is a societal perspective on innovation, where the difference between industrial society and knowledge society leads into the surge of network-driven innovation. Network-driven innovation is unfolded on top of the known cost- driven...

Positive feedback stabilization of centrifugal compressor surge

NARCIS (Netherlands)

Willems, Frank; Heemels, W.P.M.H.; de Jager, Bram; Stoorvogel, Antonie Arij

Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to

Positive feedback stabilization of centrifugal compressor surge

NARCIS (Netherlands)

Willems, F.P.T.; Heemels, W.P.M.H.; Jager, de A.G.; Stoorvogel, A.A.

2002-01-01

Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to

Assessment of surge arrester failure rate and application studies in Hellenic high voltage transmission lines

Energy Technology Data Exchange (ETDEWEB)

Christodoulou, C.A.; Fotis, G.P.; Gonos, I.F.; Stathopulos, I.A. [National Technical University of Athens, School of Electrical and Computer Engineering, High Voltage Laboratory, 9 Iroon Politechniou St., Zografou Campus, 157 80 Athens (Greece); Ekonomou, L. [A.S.PE.T.E. - School of Pedagogical and Technological Education, Department of Electrical Engineering Educators, N. Heraklion, 141 21 Athens (Greece)

2010-02-15

The use of transmission line surge arresters to improve the lightning performance of transmission lines is becoming more common. Especially in areas with high soil resistivity and ground flash density, surge arresters constitute the most effective protection mean. In this paper a methodology for assessing the surge arrester failure rate based on the electrogeometrical model is presented. Critical currents that exceed arresters rated energy stress were estimated by the use of a simulation tool. The methodology is applied on operating Hellenic transmission lines of 150 kV. Several case studies are analyzed by installing surge arresters on different intervals, in relation to the region's tower footing resistance and the ground flash density. The obtained results are compared with real records of outage rate showing the effectiveness of the surge arresters in the reduction of the recorded failure rate. The presented methodology can be proved valuable to the studies of electric power systems designers intending in a more effective lightning protection, reducing the operational costs and providing continuity of service. (author)

Evaluation of Ferrite Chip Beads as Surge Current Limiters in Circuits with Tantalum Capacitors

Science.gov (United States)

Teverovsky, Alexander

2014-01-01

Limiting resistors are currently required to be connected in series with tantalum capacitors to reduce the risk of surge current failures. However, application of limiting resistors decreases substantially the efficiency of the power supply systems. An ideal surge current limiting device should have a negligible resistance for DC currents and high resistance at frequencies corresponding to transients in tantalum capacitors. This work evaluates the possibility of using chip ferrite beads (FB) as such devices. Twelve types of small size FBs from three manufacturers were used to evaluate their robustness under soldering stresses and at high surge current spikes associated with transients in tantalum capacitors. Results show that FBs are capable to withstand current pulses that are substantially greater than the specified current limits. However, due to a sharp decrease of impedance with current, FBs do not reduce surge currents to the required level that can be achieved with regular resistors.

Recovery of high-purity metallic Pd from Pd(II)-sorbed biosorbents by incineration.

Science.gov (United States)

Won, Sung Wook; Lim, Areum; Yun, Yeoung-Sang

2013-06-01

This work reports a direct way to recover metallic palladium with high purity from Pd(II)-sorbed polyethylenimine-modified Corynebacterium glutamicum biosorbent using a combined method of biosorption and incineration. This study is focused on the incineration part which affects the purity of recovered Pd. The incineration temperature and the amount of Pd loaded on the biosorbent were considered as major factors in the incineration process, and their effects were examined. The results showed that both factors significantly affected the enhancement of the recovery efficiency and purity of the recovered Pd. SEM-EDX and XRD analyses were used to confirm that Pd phase existed in the ash. As a result, the recovered Pd was changed from PdO to zero-valent Pd as the incineration temperature was increased from 600 to 900°C. Almost 100% pure metallic Pd was recovered with recovery efficiency above 99.0% under the conditions of 900°C and 136.9 mg/g. Copyright © 2013 Elsevier Ltd. All rights reserved.

Investigating unexpected magnetism of mesoporous silica-supported Pd and PdO nanoparticles

KAUST Repository

Song, Hyon Min

2015-01-13

The synthesis and magnetic behavior of matrix-supported Pd and PdO nanoparticles (NPs) are described. Mesoporous silica with hexagonal columnal packing is selected as a template, and the impregnation method with thermal annealing is used to obtain supported Pd and PdO NPs. The heating rate and the annealing conditions determine the particle size and the phase of the NPs, with a fast heating rate of 30 °C/min producing the largest supported Pd NPs. Unusual magnetic behaviors are observed. (1) Contrary to the general belief that smaller Pd NPs or cluster size particles have higher magnetization, matrix-supported Pd NPs in this study maintain the highest magnetization with room temperature ferromagnetism when the size is the largest. (2) Twin boundaries along with stacking faults are more pronounced in these large Pd NPs and are believed to be the reason for this high magnetization. Similarly, supported PdO NPs were prepared under air conditions with different heating rates. Their phase is tetragonal (P42/mmc) with cell parameters of a = 3.050 Å and c = 5.344 Å, which are slightly larger than in the bulk phase (a = 3.03 Å, c = 5.33 Å). Faster heating rate of 30 °C/min also produces larger particles and larger magnetic hysteresis loop, although magnetization is smaller and few twin boundaries are observed compared to the supported metallic Pd NPs.

Theoretical analysis of hydrogen chemisorption on Pd(111), Re(0001) and PdML/Re(0001), ReML/Pd(111) pseudomorphic overlayers

DEFF Research Database (Denmark)

Pallassana, Venkataraman; Neurock, Matthew; Hansen, Lars Bruno

1999-01-01

not appear to provide an independent parameter for assessing surface reactivity. The weak chemisorption of hydrogen on the Pd-ML/Re(0001) surface relates to substantial lowering of the d-band center of Pd, when it is pseudomorphically deposited as a monolayer on a Re substrate. [S0163-1829(99)00331-2].......Gradient-corrected density-functional theory (DFT-GGA) periodic slab calculations have been used to analyze the binding of atomic hydrogen on monometallic Pd(111), Re(0001), and bimetallic Pd-mL/Re(0001) [pseudomorphic monolayer of Pd(111) on Re(0001)] and Re-ML/Pd(111) surfaces. The computed...

Brief communication: The Khurdopin glacier surge revisited – extreme flow velocities and formation of a dammed lake in 2017

Directory of Open Access Journals (Sweden)

J. F. Steiner

2018-01-01

Full Text Available Glacier surges occur regularly in the Karakoram, but the driving mechanisms, their frequency and its relation to a changing climate remain unclear. In this study, we use digital elevation models and Landsat imagery in combination with high-resolution imagery from the Planet satellite constellation to quantify surface elevation changes and flow velocities during a glacier surge of the Khurdopin Glacier in 2017. Results reveal that an accumulation of ice volume above a clearly defined steep section of the glacier tongue since the last surge in 1999 eventually led to a rapid surge in May 2017 peaking with velocities above 5000 m a−1, which were among the fastest rates globally for a mountain glacier. Our data reveal that velocities on the lower tongue increase steadily during a 4-year build-up phase prior to the actual surge only to then rapidly peak and decrease again within a few months, which confirms earlier observations with a higher frequency of available velocity data. The surge return period between the reported surges remains relatively constant at ca. 20 years. We show the potential of a combination of repeat Planet and ASTER imagery to (a capture peak surge velocities that are easily missed by less frequent Landsat imagery, (b observe surface changes that indicate potential drivers of a surge and (c monitor hazards associated with a surge. At Khurdopin specifically, we observe that the surging glacier blocks the river in the valley and causes a lake to form, which may grow in subsequent years and could pose threats to downstream settlements and infrastructure in the case of a sudden breach.

Extrapyramidal disease

Institute of Scientific and Technical Information of China (English)

2010-01-01

2010380 Evaluation non-motor symptoms in Parkinson’s disease and its influence on ability of daily living. WANG Rongfei(王荣飞),et al. Dept Neurol,1st Hosp,Guangzhou Med Coll,Guangzhou 510000. Chin J Neurol 2010;43(4):273-276. Objective To evaluate the non-motor symptoms (NMS) in Parkinson’s disease (PD),and its influence on ability of daily living (ADL) in PD

PD-1/PD-L1 Inhibitors for Immuno-oncology: From Antibodies to Small Molecules.

Science.gov (United States)

Geng, Qiaohong; Jiao, Peifu; Jin, Peng; Su, Gaoxing; Dong, Jinlong; Yan, Bing

2018-02-12

The recent regulatory approvals of immune checkpoint protein inhibitors, such as ipilimumab, pembrolizumab, nivolumab, atezolizumab, durvalumab, and avelumab ushered a new era in cancer therapy. These inhibitors do not attack tumor cells directly but instead mobilize the immune system to re-recognize and eradicate tumors, which endows them with unique advantages including durable clinical responses and substantial clinical benefits. PD-1/PD-L1 inhibitors, a pillar of immune checkpoint protein inhibitors, have demonstrated unprecedented clinical efficacy in more than 20 cancer types. Besides monoclonal antibodies, diverse PD- 1/PD-L1 inhibiting candidates, such as peptides, small molecules have formed a powerful collection of weapons to fight cancer. The goal of this review is to summarize and discuss the current PD-1/PD-L1 inhibitors including candidates under clinical development, their molecular interactions with PD-1 or PD-L1, the disclosed structureactivity relationships of peptides and small molecules as inhibitors. Current PD-1/PD-L1 inhibitors under clinical development are exclusively dominated by antibodies. The molecular interactions of therapeutic antibodies with PD-1 or PD-L1 have been gradually elucidated for the design of novel inhibitors. Various peptides and traditional small molecules have been investigated in preclinical model to discover novel PD-1/PD-L1 inhibitors. Peptides and small molecules may play an important role in immuno-oncology because they may bind to multiple immune checkpoint proteins via rational design, opening opportunity for a new generation of novel PD-1/PD-L1 inhibitors. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Association of morning blood pressure surge with carotid intima-media thickness and cardiac dysfunction in patients with cardiac syndrome-X.

Science.gov (United States)

Mahfouz, Ragab A; Goda, Mohammad; Galal, Islam; Ghareb, Mohamed S

2018-05-23

Background & hypothesis: We hypothesized that exaggerated morning blood pressure surge, may contribute in cardiac dysfunction and arterial stiffness in patients with cardiac syndrome X. Thus we investigated the impact of morning blood pressure surge on cardiac function and carotid intima-media thickness in subjects with cardiac syndrome X. We studied patients with cardiac syndrome X using ambulatory blood pressure monitoring and investigated the association of morning blood pressure surge with carotid intima thickness, left atrial volume index and left ventricular filling (E/e'). Seventy patients with cardiac syndrome X were enrolled for the study and compared with 70 age and sex matched controls. Patients with cardiac syndrome X were stratified based on the systolic morning blood pressure surge value of control subjects to patients with exaggerated blood pressure surge (n = 42) and those with normal morning blood pressure surge (n = 28). Basal heart rate (p blood pressure surge group than those with morning blood pressure surge group. Morning blood pressure surge was significantly correlated with carotid intima-media thickness, high sensitive C-reactive protein, left atrial volume index and E/e' ratio in patients with cardiac syndrome X. In multivariate analysis, exaggerated morning blood pressure surge was the only independent predictor of increased carotid intima-media thickness (OR = 2.379; p blood pressure surge is an independent predictor for arterial stiffness and diastolic dysfunction in patients with cardiac syndrome X.

Psychiatric phenomenology in Cushing's disease.

Science.gov (United States)

Loosen, P T; Chambliss, B; DeBold, C R; Shelton, R; Orth, D N

1992-07-01

We evaluated 20 patients with Cushing's disease (i.e., Cushing's syndrome due to ACTH-secreting pituitary microadenoma) and 20 patients with Major Depressive Disorder (MDD) using the Structured Clinical Interview for DSM-III-R (SCID) and Research Diagnostic Criteria. The diagnosis of Generalized Anxiety Disorder (GAD) was most common in Cushing's disease (79%), followed by MDD (68%), and Panic Disorder (PD) including subthreshold PD (53%). The combination of MDD and GAD and/or PD was also common in Cushing's disease (63%). Behavioral symptoms, if present, usually first occurred at or after the onset of the first physical symptoms. However, the onset of PD was associated with more chronic stages of Cushing's disease. In both Cushing's disease and MDD, more female than male relatives suffered from MDD, whereas more male than female relatives suffered from substance abuse. The data demonstrate a syndrome of anxious depression in patients with active Cushing's disease; such comorbidility has not been previously noted. The data also point to intriguing epidemiological, clinical, and biological associations between Cushing's disease, MDD and substance abuse.

A new concept for glacial geological investigations of surges, based on High-Arctic examples (Svalbard)

Science.gov (United States)

Lønne, Ida

2016-01-01

Svalbard is a key area for the investigation of glacial surges, and almost two centuries worth of field observations exists from this region. Studies have shown that the course of a surge and the associated formation of landforms are strongly influenced by basinal factors, and that the broad range of variables involved can hamper interpretations and comparisons. Based on a review of surges in Svalbard, a new concept for glacial geological investigations has been developed that combines ice-flows, ice-front movements, and morphostratigraphy. The concept is comprised of the following four elements: 1) classification based on the configuration and characteristics of the receiving basin, 2) division of the surge cycle into six stages, 3) guidelines for morphological mapping, and 4) use of an allostratigraphic approach for interpreting ice-front movements. In this context, delineation of the active phase is critical, which include the history of terminus movements, and four main categories of receiving basins are recognized. These are (A) terrestrial basins with deformable substrates, (B) terrestrial basins with poorly deformable substrates, (C) shallow water basins, and (D) deep water basins. The ice-front movement history is reconstructed by coupling information from the proglacial moraines (syn-surge), the supraglacial moraines (post-surge), and the associated traces of meltwater to the surge stages (I-VI). This approach has revealed a critical relationship between the termination of the active phase and three morphological elements, namely, the maximum ice-front position, the maximum moraine extent and the youngest proglacial moraine, which are unique for each of the basins A-D. The concept is thus a novel and more precise approach for mapping the active phase and the active phase duration, as shown by the ∼12-year long surge of Fridtjovbreen, where stage I was 30 months (inception), stage II was 54 months (ice-front advance), stage III was 12 months (stillstand

Improvement of Performance Range of Centrifugal Compressors Gas by Surge Line Modification Using Active Controller Based on Fuzzy Logic

Directory of Open Access Journals (Sweden)

Pezhman Mohammadi

2012-04-01

Full Text Available In this work, surge of prevention is a critical problem in oil and gas industries, particularly when return gas flow or gas flow reduces in transportation of gas pipelines. This paper is illustrated new results about surge control of centrifugal compressors .surge phenomenon is flow unsteady state in compressors which causes damages seriously in compressor construction. Furthermore, it also demonstrates in comparison with anti surge control ،active surge control expands stability range.Active surge control which based on fuzzy logic،is the main idea that used in this investigation. Using fuzzy controller causes an improvement in compressor's condition and increase performance range of the compressor, in addition to prevention of any instability in compressor. The simulation results is also satisfactory.

Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma.

Science.gov (United States)

Coy, Shannon; Rashid, Rumana; Lin, Jia-Ren; Du, Ziming; Donson, Andrew M; Hankinson, Todd C; Foreman, Nicholas K; Manley, Peter E; Kieran, Mark W; Reardon, David A; Sorger, Peter K; Santagata, Sandro

2018-03-02

Craniopharyngiomas are neoplasms of the sellar/parasellar region that are classified into adamantinomatous (ACP) and papillary (PCP) subtypes. Surgical resection of craniopharyngiomas is challenging, and recurrence is common, frequently leading to profound morbidity. BRAF V600E mutations render PCP susceptible to BRAF/MEK inhibitors, but effective targeted therapies are needed for ACP. We explored the feasibility of targeting the PD-1/PD-L1 immune checkpoint pathway in ACP and PCP. We mapped and quantified PD-L1 and PD-1 expression in ACP and PCP resections using immunohistochemistry, immunofluorescence, and RNA in situ hybridization. We used tissue-based cyclic immunofluorescence (t-CyCIF) to map the spatial distribution of immune cells and characterize cell cycle and signaling pathways in ACP tumor cells which intrinsically express PD-1. All ACP (15±14% of cells, n=23, average±S.D.) and PCP (35±22% of cells, n=18) resections expressed PD-L1. In ACP, PD-L1 was predominantly expressed by tumor cells comprising the cyst-lining. In PCP, PD-L1 was highly-expressed by tumor cells surrounding the stromal fibrovascular cores. ACP also exhibited tumor cell-intrinsic PD-1 expression in whorled epithelial cells with nuclear-localized beta-catenin. These cells exhibited evidence of elevated mTOR and MAPK signaling. Profiling of immune populations in ACP and PCP showed a modest density of CD8+ T-cells. ACP exhibit PD-L1 expression in the tumor cyst-lining and intrinsic PD-1 expression in cells proposed to comprise an oncogenic stem-like population. In PCP, proliferative tumor cells express PD-L1 in a continuous band at the stromal-epithelial interface. Targeting PD-L1 and/or PD-1 in both subtypes of craniopharyngioma might therefore be an effective therapeutic strategy.

Study of an integrated non-motor symptoms questionnaire for Parkinson's disease

Institute of Scientific and Technical Information of China (English)

YU Bo; XIAO Zhi-ying; LI Jia-zhen; YUAN Jing; LIU Yi-ming

2010-01-01

Background Although the validity of non-motor symptoms screening questionnaire (NMSQuest) for Parkinson's disease has been verified in several recent researches, the specificity of the questionnaire is still in doubt. This study aimed to compare the non-motor symptoms (NMS) in Parkinson's disease (PD) with a medically ill control group.Methods In this study, the first comprehensive clinic-based NMS screening questionnaire for PD developed by the Parkinson's Disease Non-Motor Group (PDNMG) was used. Data from 90 PD patients and 270 sex-and age-matched control subjects, including stroke (n=90), heart disease (n=90) and diabetes (n=90) were analyzed.Results Compared with control group, NMS was more common in PD; on an average, most PD patients reported more than 12 non-motor items. There was a correlation of total NMS score in PD patients with Hoehn & Yahr Staging, but not with age, sex distribution, disease duration, or age at disease onset. Additionally, depression, constipation and impaired olfaction which occurred prior to the motor symptoms of PD were reported in this study.Conclusions NMS are more common in PD patients. There are some NMS that occurred at the preclinical stage of PD and might predict the onset of motor symptoms of PD patients.

Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis

DEFF Research Database (Denmark)

Greisen, S R; Rasmussen, T K; Stengaard-Pedersen, K

2014-01-01

OBJECTIVES: Programmed death-1 (PD-1) is an immunoregulatory molecule functioning by down-regulating immune responses. PD-1 is present on follicular helper T cells (TFH) and is important in the formation of plasma cells. PD-1 exists in a bioactive soluble form (sPD-1) and is thought to be implica......OBJECTIVES: Programmed death-1 (PD-1) is an immunoregulatory molecule functioning by down-regulating immune responses. PD-1 is present on follicular helper T cells (TFH) and is important in the formation of plasma cells. PD-1 exists in a bioactive soluble form (sPD-1) and is thought...... Questionnaire (HAQ) score, immunoglobulin M rheumatoid factor (IgM-RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, C-reactive protein (CRP), interleukin-21 (IL-21), and total Sharp score (TSS). We also measured sPD-1 in plasma from healthy volunteers (HV) (n = 20) and in plasma and synovial fluid...

Periodontal disease and diabetes mellitus

Science.gov (United States)

NEGRATO, Carlos Antonio; TARZIA, Olinda; JOVANOVIČ, Lois; CHINELLATO, Luiz Eduardo Montenegro

2013-01-01

Periodontal disease (PD) is one of the most commonly known human chronic disorders. The relationship between PD and several systemic diseases such as diabetes mellitus (DM) has been increasingly recognized over the past decades. Objective: The purpose of this review is to provide the reader with knowledge concerning the relationship between PD and DM. Many articles have been published in the english and Portuguese literature over the last 50 years examining the relationship between these two chronic diseases. Data interpretation is often confounded by varying definitions of DM, PD and different clinical criteria were applied to determine the prevalence, extent and severity of PD, levels of glycemic control and diabetes-related complications. Methods: This paper provides a broad overview of the predominant findings from research conducted using the BBO (Bibliografia Brasileira de Odontologia), MEDLINE, LILACS and PubMed for Controlled Trials databases, in english and Portuguese languages published from 1960 to October 2012. Primary research reports on investigations of relationships between DM/DM control, PD/periodontal treatment and PD/DM/diabetes-related complications identified relevant papers and meta-analyses published in this period. Results: This paper describes the relationship between PD and DM and answers the following questions: 1- The effect of DM on PD, 2- The effects of glycemic control on PD and 3- The effects of PD on glycemic control and on diabetes-related complications. Conclusions: The scientific evidence reviewed supports diabetes having an adverse effect on periodontal health and PD having an adverse effect on glycemic control and on diabetes-related complications. Further research is needed to clarify these relationships and larger, prospective, controlled trials with ethnically diverse populations are warranted to establish that treating PD can positively influence glycemic control and possibly reduce the burden of diabetes

Periodontal disease and diabetes mellitus.

Science.gov (United States)

Negrato, Carlos Antonio; Tarzia, Olinda; Jovanovič, Lois; Chinellato, Luiz Eduardo Montenegro

2013-01-01

Periodontal disease (PD) is one of the most commonly known human chronic disorders. The relationship between PD and several systemic diseases such as diabetes mellitus (DM) has been increasingly recognized over the past decades. The purpose of this review is to provide the reader with knowledge concerning the relationship between PD and DM. Many articles have been published in the English and Portuguese literature over the last 50 years examining the relationship between these two chronic diseases. Data interpretation is often confounded by varying definitions of DM, PD and different clinical criteria were applied to determine the prevalence, extent and severity of PD, levels of glycemic control and diabetes-related complications. This paper provides a broad overview of the predominant findings from research conducted using the BBO (Bibliografia Brasileira de Odontologia), MEDLINE, LILACS and PubMed for Controlled Trials databases, in English and Portuguese languages published from 1960 to October 2012. Primary research reports on investigations of relationships between DM/DM control, PD/periodontal treatment and PD/DM/diabetes-related complications identified relevant papers and meta-analyses published in this period. This paper describes the relationship between PD and DM and answers the following questions: 1- The effect of DM on PD, 2- The effects of glycemic control on PD and 3- The effects of PD on glycemic control and on diabetes-related complications. The scientific evidence reviewed supports diabetes having an adverse effect on periodontal health and PD having an adverse effect on glycemic control and on diabetes-related complications. Further research is needed to clarify these relationships and larger, prospective, controlled trials with ethnically diverse populations are warranted to establish that treating PD can positively influence glycemic control and possibly reduce the burden of diabetes-related complications.

Improvements of Storm Surge Modelling in the Gulf of Venice with Satellite Data: The ESA Due Esurge-Venice Project

Science.gov (United States)

De Biasio, F.; Bajo, M.; Vignudelli, S.; Papa, A.; della Valle, A.; Umgiesser, G.; Donlon, C.; Zecchetto, S.

2016-08-01

Among the most detrimental natural phenomena, storm surges heavily endanger the environment, the economy and the everyday life of sea-side countries and coastal zones. Considering that 120.000.000 people live in the Mediterranean area, with additional 200.000.000 presences in Summer for tourism purposes, the correct prediction of storm surges is crucial to avoid fatalities and economic losses. Earth Observation (EO) can play an important role in operational storm surge forecasting, yet it is not widely diffused in the storm surge community. In 2011 the European Space Agency (ESA), through its Data User Element (DUE) programme, financed two projects aimed at encouraging the uptake of EO data in this sector: eSurge and eSurge-Venice (eSV). The former was intended to address the issues of a wider users' community, while the latter was focused on a restricted geographical area: the northern Adriatic Sea and the Gulf of Venice. Among the objectives of the two projects there were a number of storm surge hindcast experiments using satellite data, to demonstrate the improvements on the surge forecast brought by EO. We report here the results of the hindcast experiments of the eSV project. They were aimed to test the sensitivity of a storm surge model to a forcing wind field modified with scatterometer data in order to reduce the bias between simulated and observed winds. Hindcast experiments were also performed to test the response of the storm surge model to the assimilation, with a dual 4D-Var system, of satellite altimetry observations as model errors of the initial state of the sea surface level. Remarkable improvements on the storm surge forecast have been obtained for what concerns the modified model wind forcing. Encouraging results have been obtained also in the assimilation experiments.

Pd-nanoparticles cause increased toxicity to kiwifruit pollen compared to soluble Pd(II)

International Nuclear Information System (INIS)

Speranza, Anna; Leopold, Kerstin; Maier, Marina; Taddei, Anna Rita; Scoccianti, Valeria

2010-01-01

In the present study, endpoints including in vitro pollen performance (i.e., germination and tube growth) and lethality were used as assessments of nanotoxicity. Pollen was treated with 5-10 nm-sized Pd particles, similar to those released into the environment by catalytic car exhaust converters. Results showed Pd-nanoparticles altered kiwifruit pollen morphology and entered the grains more rapidly and to a greater extent than soluble Pd(II). At particulate Pd concentrations well below those of soluble Pd(II), pollen grains experienced rapid losses in endogenous calcium and pollen plasma membrane damage was induced. This resulted in severe inhibition and subsequent cessation of pollen tube emergence and elongation at particulate Pd concentrations as low as 0.4 mg L -1 . Particulate Pd emissions related to automobile traffic have been increasing and are accumulating in the environment. This could seriously jeopardize in vivo pollen function, with impacts at an ecosystem level. - Nanoparticulate Pd - which resembles emissions from automobile catalysts - affects pollen to a higher extent than soluble Pd.

Pd-nanoparticles cause increased toxicity to kiwifruit pollen compared to soluble Pd(II)

Energy Technology Data Exchange (ETDEWEB)

Speranza, Anna, E-mail: anna.speranza@unibo.i [Dipartimento di Biologia, Universita di Bologna, via Irnerio 42, 40126 Bologna (Italy); Leopold, Kerstin, E-mail: kerstin.leopold@lrz.tu-muenchen.d [Arbeitsgruppe fuer Analytische Chemie, Technische Universitaet Muenchen, Garching (Germany); Maier, Marina, E-mail: marina.maier@ch.tum.d [Arbeitsgruppe fuer Analytische Chemie, Technische Universitaet Muenchen, Garching (Germany); Taddei, Anna Rita, E-mail: artaddei@unitus.i [CIME, Universita della Tuscia, Viterbo (Italy); Scoccianti, Valeria, E-mail: valeria.scoccianti@uniurb.i [Dipartimento di Scienze dell' Uomo, dell' Ambiente e della Natura, Universita di Urbino ' Carlo Bo' , Urbino (Italy)

2010-03-15

In the present study, endpoints including in vitro pollen performance (i.e., germination and tube growth) and lethality were used as assessments of nanotoxicity. Pollen was treated with 5-10 nm-sized Pd particles, similar to those released into the environment by catalytic car exhaust converters. Results showed Pd-nanoparticles altered kiwifruit pollen morphology and entered the grains more rapidly and to a greater extent than soluble Pd(II). At particulate Pd concentrations well below those of soluble Pd(II), pollen grains experienced rapid losses in endogenous calcium and pollen plasma membrane damage was induced. This resulted in severe inhibition and subsequent cessation of pollen tube emergence and elongation at particulate Pd concentrations as low as 0.4 mg L{sup -1}. Particulate Pd emissions related to automobile traffic have been increasing and are accumulating in the environment. This could seriously jeopardize in vivo pollen function, with impacts at an ecosystem level. - Nanoparticulate Pd - which resembles emissions from automobile catalysts - affects pollen to a higher extent than soluble Pd.

Smartphone- and internet-assisted self-management and adherence tools to manage Parkinson's disease (SMART-PD): study protocol for a randomised controlled trial (v7; 15 August 2014).

Science.gov (United States)

Lakshminarayana, Rashmi; Wang, Duolao; Burn, David; Chaudhuri, K Ray; Cummins, Gemma; Galtrey, Clare; Hellman, Bruce; Pal, Suvankar; Stamford, Jon; Steiger, Malcolm; Williams, Adrian

2014-09-25

Nonadherence to treatment leads to suboptimal treatment outcomes and enormous costs to the economy. This is especially important in Parkinson's disease (PD). The progressive nature of the degenerative process, the complex treatment regimens and the high rates of comorbid conditions make treatment adherence in PD a challenge. Clinicians have limited face-to-face consultation time with PD patients, making it difficult to comprehensively address non-adherence. The rapid growth of digital technologies provides an opportunity to improve adherence and the quality of decision-making during consultation. The aim of this randomised controlled trial (RCT) is to evaluate the impact of using a smartphone and web applications to promote patient self-management as a tool to increase treatment adherence and working with the data collected to enhance the quality of clinical consultation. A 4-month multicentre RCT with 222 patients will be conducted to compare use of a smartphone- and internet-enabled Parkinson's tracker smartphone app with treatment as usual for patients with PD and/or their carers. The study investigators will compare the two groups immediately after intervention. Seven centres across England (6) and Scotland (1) will be involved. The primary objective of this trial is to assess whether patients with PD who use the app show improved medication adherence compared to those receiving treatment as usual alone. The secondary objectives are to investigate whether patients who receive the app and those who receive treatment as usual differ in terms of quality of life, quality of clinical consultation, overall disease state and activities of daily living. We also aim to investigate the experience of those receiving the intervention by conducting qualitative interviews with a sample of participants and clinicians, which will be administered by independent researchers. ISRCTN45824264 (registered 5 November 2013).

An Exploration of Wind Stress Calculation Techniques in Hurricane Storm Surge Modeling

Directory of Open Access Journals (Sweden)

Kyra M. Bryant

2016-09-01

Full Text Available As hurricanes continue to threaten coastal communities, accurate storm surge forecasting remains a global priority. Achieving a reliable storm surge prediction necessitates accurate hurricane intensity and wind field information. The wind field must be converted to wind stress, which represents the air-sea momentum flux component required in storm surge and other oceanic models. This conversion requires a multiplicative drag coefficient for the air density and wind speed to represent the air-sea momentum exchange at a given location. Air density is a known parameter and wind speed is a forecasted variable, whereas the drag coefficient is calculated using an empirical correlation. The correlation’s accuracy has brewed a controversy of its own for more than half a century. This review paper examines the lineage of drag coefficient correlations and their acceptance among scientists.

Disaster metrics: quantitative benchmarking of hospital surge capacity in trauma-related multiple casualty events.

Science.gov (United States)

Bayram, Jamil D; Zuabi, Shawki; Subbarao, Italo

2011-06-01

Hospital surge capacity in multiple casualty events (MCE) is the core of hospital medical response, and an integral part of the total medical capacity of the community affected. To date, however, there has been no consensus regarding the definition or quantification of hospital surge capacity. The first objective of this study was to quantitatively benchmark the various components of hospital surge capacity pertaining to the care of critically and moderately injured patients in trauma-related MCE. The second objective was to illustrate the applications of those quantitative parameters in local, regional, national, and international disaster planning; in the distribution of patients to various hospitals by prehospital medical services; and in the decision-making process for ambulance diversion. A 2-step approach was adopted in the methodology of this study. First, an extensive literature search was performed, followed by mathematical modeling. Quantitative studies on hospital surge capacity for trauma injuries were used as the framework for our model. The North Atlantic Treaty Organization triage categories (T1-T4) were used in the modeling process for simplicity purposes. Hospital Acute Care Surge Capacity (HACSC) was defined as the maximum number of critical (T1) and moderate (T2) casualties a hospital can adequately care for per hour, after recruiting all possible additional medical assets. HACSC was modeled to be equal to the number of emergency department beds (#EDB), divided by the emergency department time (EDT); HACSC = #EDB/EDT. In trauma-related MCE, the EDT was quantitatively benchmarked to be 2.5 (hours). Because most of the critical and moderate casualties arrive at hospitals within a 6-hour period requiring admission (by definition), the hospital bed surge capacity must match the HACSC at 6 hours to ensure coordinated care, and it was mathematically benchmarked to be 18% of the staffed hospital bed capacity. Defining and quantitatively benchmarking the

Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents.

Science.gov (United States)

Asín-Prieto, Eduardo; Rodríguez-Gascón, Alicia; Isla, Arantxazu

2015-05-01

The alarming increase of resistance against multiple currently available antibiotics is leading to a rapid lose of treatment options against infectious diseases. Since the antibiotic resistance is partially due to a misuse or abuse of the antibiotics, this situation can be reverted when improving their use. One strategy is the optimization of the antimicrobial dosing regimens. In fact, inappropriate drug choice and suboptimal dosing are two major factors that should be considered because they lead to the emergence of drug resistance and consequently, poorer clinical outcomes. Pharmacokinetic/pharmacodynamic (PK/PD) analysis in combination with Monte Carlo simulation allows to optimize dosing regimens of the antibiotic agents in order to conserve their therapeutic value. Therefore, the aim of this review is to explain the basis of the PK/PD analysis and associated techniques, and provide a brief revision of the applications of PK/PD analysis from a therapeutic point-of-view. The establishment and reevaluation of clinical breakpoints is the sticking point in antibiotic therapy as the clinical use of the antibiotics depends on them. Two methodologies are described to establish the PK/PD breakpoints, which are a big part of the clinical breakpoint setting machine. Furthermore, the main subpopulations of patients with altered characteristics that can condition the PK/PD behavior (such as critically ill, elderly, pediatric or obese patients) and therefore, the outcome of the antibiotic therapy, are reviewed. Finally, some recommendations are provided from a PK/PD point of view to enhance the efficacy of prophylaxis protocols used in surgery. Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

Institute of Scientific and Technical Information of China (English)

Weidong Le; Jie Dong; Song Li; Amos D.Korczyn

2017-01-01

Parkinson's disease (PD) is a complex neurodegenerative disease with progressive loss of dopamine neurons.PD patients usually manifest a series of motor and non-motor symptoms.In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients,there is an urgent need to identify sensitive and specific biomarkers.Biomarkers can be divided into four categories:clinical,imaging,biochemical,and genetic.Ideal biomarkers not only improve our understanding of PD pathogenesis and progression,but also provide benefits for early risk evaluation and clinical diagnosis of PD.Although many efforts have been made and several biomarkers have been extensively investigated,few if any have been found useful for early diagnosis.Here,we summarize recent developments in the discovered biomarkers of PD and discuss their merits and limitations for the early diagnosis of PD.

Role of exogenous estrogen in initiation of estrus and induction of an LH surge

Science.gov (United States)

Among cattle the LH surge that causes ovulation occurs shortly after the onset of a spontaneous estrus. In addition an injection of 100 'g of GnRH can induce an LH surge capable of inducing ovulation. We hypothesized that different preovulatory estradiol profiles would result in different ovulator...

Coffee, Genetic Variants, and Parkinson's Disease: Gene–Environment Interactions

OpenAIRE

Yamada-Fowler, Naomi; Söderkvist, Peter

2015-01-01

Studies of gene–environment interactions may help us to understand the disease mechanisms of common and complex diseases such as Parkinson's disease (PD). Sporadic PD, the common form of PD, is thought to be a multifactorial disorder caused by combinations of multiple genetic factors and environmental or life-style exposures. Since one of the most extensively studied life-style factors in PD is coffee/caffeine intake, here, the studies of genetic polymorphisms with life-style interactions of ...

Photoreceptor dysplasia (pd) in miniature schnauzer dogs: evaluation of candidate genes by molecular genetic analysis.

Science.gov (United States)

Zhang, Q; Baldwin, V J; Acland, G M; Parshall, C J; Haskel, J; Aguirre, G D; Ray, K

1999-01-01

Photoreceptor dysplasia (pd) is one of a group of at least six distinct autosomal and one X-linked retinal disorders identified in dogs which are collectively known as progressive retinal atrophy (PRA). It is an early onset retinal disease identified in miniature schnauzer dogs, and pedigree analysis and breeding studies have established autosomal recessive inheritance of the disease. Using a gene-based approach, a number of retina-expressed genes, including some members of the phototransduction pathway, have been causally implicated in retinal diseases of humans and other animals. Here we examined seven such potential candidate genes (opsin, RDS/peripherin, ROM1, rod cGMP-gated cation channel alpha-subunit, and three subunits of transducin) for their causal association with the pd locus by testing segregation of intragenic markers with the disease locus, or, in the absence of informative polymorphisms, sequencing of the coding regions of the genes. Based on these results, we have conclusively excluded four photoreceptor-specific genes as candidates for pd by linkage analysis. For three other photoreceptor-specific genes, we did not find any mutation in the coding sequences of the genes and have excluded them provisionally. Formal exclusion would require investigation of the levels of expression of the candidate genes in pd-affected dogs relative to age-matched controls. At present we are building suitable informative pedigrees for the disease locus with a sufficient number of meiosis to be useful for genomewide screening. This should identify markers linked to the disease locus and eventually permit progress toward the identification of the photoreceptor dysplasia gene and the disease-causing mutation.

Dynamic Model of Centrifugal Compressor for Prediction of Surge Evolution and Performance Variations

International Nuclear Information System (INIS)

Jung, Mooncheong; Han, Jaeyoung; Yu, Sangseok

2016-01-01

When a control algorithm is developed to protect automotive compressor surges, the simulation model typically selects an empirically determined look-up table. However, it is difficult for a control oriented empirical model to show surge characteristics of the super charger. In this study, a dynamic supercharger model is developed to predict the performance of a centrifugal compressor under dynamic load follow-up. The model is developed using Simulink® environment, and is composed of a compressor, throttle body, valves, and chamber. Greitzer’s compressor model is used, and the geometric parameters are achieved by the actual supercharger. The simulation model is validated with experimental data. It is shown that compressor surge is effectively predicted by this dynamic compressor model under various operating conditions.

Dynamic Model of Centrifugal Compressor for Prediction of Surge Evolution and Performance Variations

Energy Technology Data Exchange (ETDEWEB)

Jung, Mooncheong; Han, Jaeyoung; Yu, Sangseok [Chungnam National Univ., Daejeon (Korea, Republic of)

2016-05-15

When a control algorithm is developed to protect automotive compressor surges, the simulation model typically selects an empirically determined look-up table. However, it is difficult for a control oriented empirical model to show surge characteristics of the super charger. In this study, a dynamic supercharger model is developed to predict the performance of a centrifugal compressor under dynamic load follow-up. The model is developed using Simulink® environment, and is composed of a compressor, throttle body, valves, and chamber. Greitzer’s compressor model is used, and the geometric parameters are achieved by the actual supercharger. The simulation model is validated with experimental data. It is shown that compressor surge is effectively predicted by this dynamic compressor model under various operating conditions.

Observing storm surges in the Bay of Bengal from satellite altimetry

Digital Repository Service at National Institute of Oceanography (India)

Antony, C.; Testut, L.; Unnikrishnan, A.S.

with the large tidal ranges give rise to extreme sea level in the head bay and surrounding regions. Moreover, low-lying nature of the coast and the dense population in the region make the coasts of the northern Bay of Bengal highly vulnerable to storm surges...-gauge data during the passage of the hurricane Igor that crossed Newfoundland in 2010. For this event, St. John’s tide gauge recorded a maximum surge of 94 cm and Jason-2 (the track located 89 km away from the tide-gauge station) showed positive sea-level...

Pain in Neurodegenerative Disease : Current Knowledge and Future Perspectives

NARCIS (Netherlands)

de Tommaso, Marina; Arendt-Nielsen, Lars; Defrin, Ruth; Kunz, Miriam; Pickering, Gisele; Valeriani, Massimiliano

2016-01-01

Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD),

Magnetotransport in Pd-rich PdFe alloys

Czech Academy of Sciences Publication Activity Database

Kudrnovský, Josef; Drchal, Václav; Turek, Ilja

2013-01-01

Roč. 26, č. 5 (2013), s. 1749-1752 ISSN 1557-1939 R&D Projects: GA ČR(CZ) GAP204/11/1228 Institutional support: RVO:68378271 ; RVO:68081723 Keywords : galvanomagnetic transport * Pd-rich PdFe * long-range order * effect of temperature * anisotropic magnetoresistance Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.930, year: 2013

The genetic basis of Parkinson's disease

Directory of Open Access Journals (Sweden)

A. A. Tappakhov

2017-01-01

Full Text Available Parkinson's disease (PD is a multifactorial disease that develops in the presence of both genetic and environmental factors. In recent years, there has been sufficient information on the role of genetic predisposition in the development of not only familial cases, but also sporadic ones. A hereditary burden in PD may not be traced in cases of recessive inheritance with a low gene penetrance, as well as in a patient's death before the onset of the disease. Active introduction of molecular genetic methods, including next generation sequencing, can annually identify new gene mutations that underlie sporadic PD cases. This paper provides an overview of the current literature on the genetic aspects of PD with emphasis on the ethnic characteristics of the disease.

The Danger of Deja Vu: Why the Iraq Surge is Not a Lesson for Afghanistan

Science.gov (United States)

2010-01-01

JAN 2010 2. REPORT TYPE 3. DATES COVERED 00-12-2009 to 00-01-2010 4. TITLE AND SUBTITLE The danger of deja vu . Why the Iraq surge is not a lesson...of five brigade combat teams — eerily mim- icked the surge number for Iraq. And there was more déjà vu when our senior civilian and military leaders...Department. PERSPECTIVES The danger of déjà vu Why the Iraq surge is not a lesson for Afghanistan BY COL. CHARLES D. ALLEN (RET.) The thing we take hold of

Driving safety in Parkinson's disease.

Science.gov (United States)

Zesiewicz, T A; Cimino, C R; Malek, A R; Gardner, N; Leaverton, P L; Dunne, P B; Hauser, R A

2002-12-10

In this study, 39 patients with PD and 25 control subjects without neurologic disease completed testing in a driving simulator. PD patients had more total collisions on the driving simulator than control subjects (t = -3.7, p < 0.01). In PD patients, collisions were associated with Hoehn and Yahr stage (chi(2) = 12.4, p = 0.006) and correlated with Unified Parkinson's Disease Rating Scale score (r = 0.5, p < 0.01).

Pain Correlates with Sleep Disturbances in Parkinson's Disease Patients.

Science.gov (United States)

Fu, Yun-Ting; Mao, Cheng-Jie; Ma, Li-Jing; Zhang, Hui-Jun; Wang, Yi; Li, Jie; Huang, Jun-Ying; Liu, Jun-Yi; Liu, Chun-Feng

2018-01-01

Both sleep disorders and pain decrease quality of life in patients with Parkinson's disease (PD). However, little is known about the relationship between objective sleep disturbances and pain in patients with PD. This study aimed to (1) examine the clinical characteristics of pain in PD patients and (2) explore the correlation between pain and sleep disturbances in PD patients. Parkinson's disease patients (N = 144) underwent extensive clinical evaluations of motor and nonmotor symptoms and characteristics of pain. Overnight video-polysomnography was also conducted. Clinical characteristics and sleep parameters were compared between PD patients with or without pain. Pain was reported by 75 patients (52.1%), with 49 (65.3%) reporting pain of at least moderate severity. PD patients with pain were older and had longer disease duration, more severe PD symptoms as assessed by Hoehn and Yahr stage and the Unified Parkinson's Disease Rating Scale, and higher L-dopa equivalent daily dose compared with PD patients without pain. PD patients with pain also showed significantly decreased sleep efficiency (57.06% ± 15.84% vs. 73.80% ± 12.00%, P daily living, depressed mood, higher percentage of N1 sleep, and lower sleep efficiency were independent predictors of pain in patients with PD. Musculoskeletal pain is the most common type of pain in patients with PD. Disrupted sleep continuity, altered sleep architecture, depressed mood, and compromised activities of daily living may be associated with pain in patients with PD. © 2017 World Institute of Pain.

Old and new challenges in Parkinson's disease therapeutics.

Science.gov (United States)

Pires, Ana O; Teixeira, F G; Mendes-Pinheiro, B; Serra, Sofia C; Sousa, Nuno; Salgado, António J

2017-09-01

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and/or loss od neuronal projections, in several dopaminergic networks. Current treatments for idiopathic PD rely mainly on the use of pharmacologic agents to improve motor symptomatology of PD patients. Nevertheless, so far PD remains an incurable disease. Therefore, it is of utmost importance to establish new therapeutic strategies for PD treatment. Over the last 20 years, several molecular, gene and cell/stem-cell therapeutic approaches have been developed with the aim of counteracting or retarding PD progression. The scope of this review is to provide an overview of PD related therapies and major breakthroughs achieved within this field. In order to do so, this review will start by focusing on PD characterization and current treatment options covering thereafter molecular, gene and cell/stem cell-based therapies that are currently being studied in animal models of PD or have recently been tested in clinical trials. Among stem cell-based therapies, those using MSCs as possible disease modifying agents for PD therapy and, specifically, the MSCs secretome contribution to meet the clinical challenge of counteracting or retarding PD progression, will be more deeply explored. Copyright © 2017 Elsevier Ltd. All rights reserved.

14 CFR 33.65 - Surge and stall characteristics.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Surge and stall characteristics. 33.65 Section 33.65 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... stall characteristics. When the engine is operated in accordance with operating instructions required by...

Surge control of the electrically driven centrifugal compressor

NARCIS (Netherlands)

Boinov, K.O.; Lomonova, E.A.; Vandenput, A.J.A.; Tyagounov, A.

2006-01-01

This paper presents a method of the energy efficiency and the operational performance improvement of the electrically driven air compression system. The key innovation of the proposed method-the active surge suppression of the centrifugal compressor by means of the speed control of the electrical

Specific Consideration on Superior Performance and Evaluation Methods of Polymer-housed Surge Arresters

Science.gov (United States)

Ishizaki, Yoshihiro; Kobayashi, Misao; Suzuki, Hironori; Futagami, Koichi

It is very suitable to select the polymer materials for the housings of surge arresters (SAs), because the polymer materials are generally soft and light weight. Therefore, many kinds of polymer-housed SAs using various polymer materials have been developed, and expanding into many countries. Considering these backgrounds, the JEC technical report (JEC-TR) 23002-2008; polymer-housed surge arrester(1) has been established based on the existent relevant standards of arresters, such as JEC-2371-2003; Insulator-housed surge arresters(2) and IEC 60099-4 Edition 2.2, Metal-oxide surge arresters (MOSAs) without gaps for a.c. systems(3) in order to introduce the technology and provide a common guide for testing of polymer-housed SAs. According as the JEC-TR, the various new applications of the polymer-housed SAs, which are caused by superior advantages such as compact, light weight, safe failure mode, anti-seismic performance, anti-pollution performance and cost efficiency design, have been realized recently in Japan. Therefore, this paper gives specific consideration on the superior performance of the polymer-housed SAs and the evaluation methods of the polymer-housed SAs, because there are some issues in the existent standards to be solved.

What can the treatment of Parkinson's disease learn from dementia care; applying a bio-psycho-social approach to Parkinson's disease.

Science.gov (United States)

Gibson, Grant

2017-12-01

Within contemporary medical practice, Parkinson's disease (PD) is treated using a biomedical, neurological approach, which although bringing numerous benefits can struggle to engage with how people with PD experience the disease. A bio-psycho-social approach has not yet been established in PD; however, bio-psycho-social approaches adopted within dementia care practice could bring significant benefit to PD care. This paper summarises existing bio-psycho-social models of dementia care and explores how these models could also usefully be applied to care for PD. Specifically, this paper adapts the bio-psycho-social model for dementia developed by Spector and Orrell (), to suggest a bio-psycho-social model, which could be used to inform routine care in PD. Drawing on the biopsychosocial model of Dementia put forward by Spector and Orrell (), this paper explores the application of a bio-psycho-social model of PD. This model conceptualises PD as a trajectory, in which several interrelated fixed and tractable factors influence both PD's symptomology and the various biological and psychosocial challenges individuals will face as their disease progresses. Using an individual case study, this paper then illustrates how such a model can assist clinicians in identifying suitable interventions for people living with PD. This model concludes by discussing how a bio-psycho-social model could be used as a tool in PD's routine care. The model also encourages the development of a theoretical and practical framework for the future development of the role of the PD specialist nurse within routine practice. A biopsychosocial approach to Parkinson's Disease provides an opportunity to move towards a holistic model of care practice which addresses a wider range of factors affecting people living with PD. The paper puts forward a framework through which PD care practice can move towards a biopsychosocial perspective. PD specialist nurses are particularly well placed to adopt such a model

Assessment of the Temporal Evolution of Storm Surge via Land to Water Isopleths in Coastal Louisiana

Science.gov (United States)

Siverd, C. G.; Hagen, S. C.; Bilskie, M. V.; Braud, D.; Gao, S.; Peele, H.; Twilley, R.

2017-12-01

The low-lying coastal Louisiana deltaic landscape features an intricate system of fragmented wetlands, natural ridges, man-made navigation canals and flood protection infrastructure. Since 1900 and prior to the landfall of Hurricane Katrina in 2005, Louisiana lost approximately 480,000 ha (1,850 sq mi) of coastal wetlands and an additional 20,000 ha (77 sq mi) due to Katrina. This resulted in a total wetland storm protection value loss of USD 28.3 billion and USD 1.1 billion, respectively (Costanza 2008). To investigate the response of hurricane storm surge (e.g. peak water levels, inundation time and extent) through time due to land loss, hydrodynamic models that represent historical eras of the Louisiana coastal landscape were developed. Land:Water (L:W) isopleths (Gagliano 1970, 1971, Twilley 2016) have been calculated along the coast from the Sabine River to the Pearl River. These isopleths were utilized to create a simplified coastal landscape (bathymetry, topography, bottom roughness) representing circa 2010. Similar methodologies are employed with the objective of developing storm surge models that represent the coastal landscape for past eras. The goal is to temporally examine the evolution of storm surge along coastal Louisiana. The isopleths determined to best represent the Louisiana coast as a result of the methodology devised to develop the simple storm surge model for c.2010 are applied in the development of surge models for historical eras c.1930 and c.1970. The ADvaced CIRCulation (ADCIRC) code (Luettich 2004) is used to perform storm surge simulations with a predetermined suite of hurricane wind and pressure forcings. Hydrologic Unit Code 12 (HUC12) sub-watersheds provide geographical bounds to quantify mean maximum water surface elevations (WSEs), volume of inundation, and area of inundation. HUC12 sub-watersheds also provide a means to compare/contrast these quantified surge parameters on a HUC12-by-HUC12 basis for the c.1930, c.1970 and c.2010

Intracerebroventricular Infusion of Vasoactive Intestinal Peptide (VIP Rescues the Luteinizing Hormone Surge in Middle-Aged Female Rats

Directory of Open Access Journals (Sweden)

Yan eSun

2012-02-01

Full Text Available Reproductive aging is characterized by delayed and attenuated luteinizing hormone (LH surges apparent in middle-aged rats. The suprachiasmatic nucleus (SCN contains the circadian clock that is responsible for the timing of diverse neuroendocrine rhythms. Electrophysiological studies suggest vasoactive intestinal peptide (VIP originating from the SCN excites gonadotropin-releasing hormone (GnRH neurons and affects daily patterns of GnRH-LH release. Age-related LH surge dysfunction correlates with reduced VIP mRNA expression in the SCN and fewer GnRH neurons with VIP contacts expressing c-fos, a marker of neuronal activation, on the day of the LH surge. To determine if age-related LH surge dysfunction reflects reduced VIP availability or altered VIP responsiveness under estradiol positive feedback conditions, we assessed the effect of intracerebroventricular (icv VIP infusion on c-fos expression in GnRH neurons and on LH release in ovariohysterectomized, hormone-primed young and middle-aged rats. Icv infusion of VIP between 1300 and 1600 h significantly advanced the time of peak LH release, increased total and peak LH release, and increased the number of GnRH neurons expressing c-fos on the day of the LH surge in middle-aged rats. Surprisingly, icv infusion of VIP in young females significantly reduced the number of GnRH neurons expressing c-fos and delayed and reduced the LH surge. These observations suggest that a critical balance of VIP signaling is required to activate GnRH neurons for an appropriately timed and robust LH surge in young and middle-aged females. Age-related LH surge changes may, in part, result from decreased availability and reduced VIP-mediated neurotransmission under estradiol positive feedback conditions.

Effect of bottle height and aspiration rate on postocclusion surge in Infiniti and Millennium peristaltic phacoemulsification machines.

Science.gov (United States)

Ward, Matthew S; Georgescu, Dan; Olson, Randall J

2008-08-01

To assess how flow and bottle height affect postocclusion surge in the Infiniti (Alcon, Inc.) and Millennium (Bausch & Lomb) peristaltic machines. John A. Moran Eye Center Clinical Laboratories, University of Utah, Salt Lake City, Utah. Postocclusion anterior chamber depth changes were measured in human eye-bank eyes using A-scan. Surge was simulated by clamping the aspiration tubing and releasing it at maximum vacuum. In both machines, surge was measured (1) with aspiration held constant at 12 mL/min and bottle heights at 60, 120, and 180 cm and (2) with bottle height held constant at 60 cm and aspiration rates at 12, 24, and 36 mL/min. Surge decreased approximately 40% with each 60 cm increase in bottle height in the Infiniti. It was constant at all bottle heights in the Millennium. At 12 and 24 mL/min aspiration rates, surge in the Millennium was less than half that in the Infiniti (PInfiniti system and was relatively constant with increasing bottle height in the Millennium system. The Millennium may offer a more stable phacoemulsification platform with respect to surge at a higher aspiration rate.

High Resolution Hurricane Storm Surge and Inundation Modeling (Invited)

Science.gov (United States)

Luettich, R.; Westerink, J. J.

2010-12-01

Coastal counties are home to nearly 60% of the U.S. population and industry that accounts for over 16 million jobs and 10% of the U.S. annual gross domestic product. However, these areas are susceptible to some of the most destructive forces in nature, including tsunamis, floods, and severe storm-related hazards. Since 1900, tropical cyclones making landfall on the US Gulf of Mexico Coast have caused more than 9,000 deaths; nearly 2,000 deaths have occurred during the past half century. Tropical cyclone-related adjusted, annualized losses in the US have risen from 1.3 billion from 1949-1989, to 10.1 billion from 1990-1995, and $35.8 billion per year for the period 2001-2005. The risk associated with living and doing business in the coastal areas that are most susceptible to tropical cyclones is exacerbated by rising sea level and changes in the characteristics of severe storms associated with global climate change. In the five years since hurricane Katrina devastated the northern Gulf of Mexico Coast, considerable progress has been made in the development and utilization of high resolution coupled storm surge and wave models. Recent progress will be presented with the ADCIRC + SWAN storm surge and wave models. These tightly coupled models use a common unstructured grid in the horizontal that is capable of covering large areas while also providing high resolution (i.e., base resolution down to 20m plus smaller subgrid scale features such as sea walls and levees) in areas that are subject to surge and inundation. Hydrodynamic friction and overland winds are adjusted to account for local land cover. The models scale extremely well on modern high performance computers allowing rapid turnaround on large numbers of compute cores. The models have been adopted for FEMA National Flood Insurance Program studies, hurricane protection system design and risk analysis, and quasi-operational forecast systems for several regions of the country. They are also being evaluated as

Elevation Change, Mass Balance, Dynamics, and Surging of Langjökull, Iceland from 1997 to 2007

OpenAIRE

Pope, Allen; Willis, Ian Craig; Pálsson, Finnur; Arnold, Neil Stuart; Rees, William Gareth; Björnsson, Helgi; Grey, Lauren

2016-01-01

Glaciers and ice caps around the world are changing quickly, with surge-type behaviour superimposed upon climatic forcing. Here, we study Iceland’s second largest ice cap, Langjökull, which has both surge- and non-surge-type outlets. By differencing elevation change with surface mass balance, we estimate the contribution of ice dynamics to elevation change. We use DEMs, in situ stake measurements, regional reanalyses, and a mass balance model to calculate the vertical ice velocity. Thus,...

Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.

Science.gov (United States)

Peled, Michael; Tocheva, Anna S; Sandigursky, Sabina; Nayak, Shruti; Philips, Elliot A; Nichols, Kim E; Strazza, Marianne; Azoulay-Alfaguter, Inbar; Askenazi, Manor; Neel, Benjamin G; Pelzek, Adam J; Ueberheide, Beatrix; Mor, Adam

2018-01-16

Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications. Nevertheless, a significant proportion of patients do not respond to anti-PD-1 treatment, and a better understanding of the signaling pathways downstream of PD-1 could provide biomarkers for those whose tumors respond and new therapeutic approaches for those whose tumors do not. We used affinity purification mass spectrometry to uncover multiple proteins associated with PD-1. Among these proteins, signaling lymphocytic activation molecule-associated protein (SAP) was functionally and mechanistically analyzed for its contribution to PD-1 inhibitory responses. Silencing of SAP augmented and overexpression blocked PD-1 function. T cells from patients with X-linked lymphoproliferative disease (XLP), who lack functional SAP, were hyperresponsive to PD-1 signaling, confirming its inhibitory role downstream of PD-1. Strikingly, signaling downstream of PD-1 in purified T cell subsets did not correlate with PD-1 surface expression but was inversely correlated with intracellular SAP levels. Mechanistically, SAP opposed PD-1 function by acting as a molecular shield of key tyrosine residues that are targets for the tyrosine phosphatase SHP2, which mediates PD-1 inhibitory properties. Our results identify SAP as an inhibitor of PD-1 function and SHP2 as a potential therapeutic target in patients with XLP.

Risks of Coastal Storm Surge and the Effect of Sea Level Rise in the Red River Delta, Vietnam

OpenAIRE

Neumann, James; Ludwig, Lindsay; Verly, Caroleen; Emanuel, Kerry Andrew; Ravela, Srinivas

2015-01-01

This paper considers the impact of sea level rise and storm surge on the Red River delta region of Vietnam an area already known to be highly vulnerable to coastal risks. By combining a range of sea level rise scenarios for 2050 with the simulated storm surge level for the 100-year storm surge, we analyze permanently inundated lands and temporary flood zones. As is well-established in the literature, sea level rise will increase the risk of storms by raising the base sea level from which surg...

PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy

Directory of Open Access Journals (Sweden)

Junyu Long

2017-08-01

Full Text Available Abstract Gastrointestinal (GI malignancies are the most prevalent tumors worldwide, with increasing incidence and mortality. Although surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy have led to significant advances in the treatment of GI cancer patients, overall survival is still low. Therefore, alternative strategies must be identified to improve patient outcomes. In the tumor microenvironment, tumor cells can escape the host immune response through the interaction of PD-1 and PD-L, which inhibits the function of T cells and tumor-infiltrating lymphocytes while increasing the function of immunosuppressive T regulatory cells. The use of an anti-PD-1/PD-L blockade enables reprogramming of the immune system to efficiently identify and kill tumor cells. In recent years, the efficacy of PD-1/PD-L blockade has been demonstrated in many tumors, and this treatment is expected to be a pan-immunotherapy for tumors. Here, we review the signaling pathway underlying the dysregulation of PD-1/PD-L in tumors, summarize the current clinical data for PD-1/PD-L inhibitors in GI malignancies, and discuss road toward precision immunotherapy in relation to PD-1/PD-L blockade. The preliminary data for PD-1/PD-L inhibitors are encouraging, and the precision immunotherapy of PD-1/PD-L inhibitors will be a viable and pivotal clinical strategy for GI cancer therapy.

PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy.

Science.gov (United States)

Long, Junyu; Lin, Jianzhen; Wang, Anqiang; Wu, Liangcai; Zheng, Yongchang; Yang, Xiaobo; Wan, Xueshuai; Xu, Haifeng; Chen, Shuguang; Zhao, Haitao

2017-08-03

Gastrointestinal (GI) malignancies are the most prevalent tumors worldwide, with increasing incidence and mortality. Although surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy have led to significant advances in the treatment of GI cancer patients, overall survival is still low. Therefore, alternative strategies must be identified to improve patient outcomes. In the tumor microenvironment, tumor cells can escape the host immune response through the interaction of PD-1 and PD-L, which inhibits the function of T cells and tumor-infiltrating lymphocytes while increasing the function of immunosuppressive T regulatory cells. The use of an anti-PD-1/PD-L blockade enables reprogramming of the immune system to efficiently identify and kill tumor cells. In recent years, the efficacy of PD-1/PD-L blockade has been demonstrated in many tumors, and this treatment is expected to be a pan-immunotherapy for tumors. Here, we review the signaling pathway underlying the dysregulation of PD-1/PD-L in tumors, summarize the current clinical data for PD-1/PD-L inhibitors in GI malignancies, and discuss road toward precision immunotherapy in relation to PD-1/PD-L blockade. The preliminary data for PD-1/PD-L inhibitors are encouraging, and the precision immunotherapy of PD-1/PD-L inhibitors will be a viable and pivotal clinical strategy for GI cancer therapy.

Full scale lightning surge tests of distribution transformers and secondary systems

International Nuclear Information System (INIS)

Goedde, G.L.; Dugan, R.C. Sr.; Rowe, L.D.

1992-01-01

This paper reports that low-side surges are known to cause failures of distribution transformers. They also subject load devices to overvoltages. A full-scale model of a residential service has been set up in a laboratory and subjected to impulses approximating lightning strokes. The tests were made to determine the impulse characteristics of the secondary system and to test the validity of previous analyses. Among the variables investigated were stroke location, the balance of the surges in the service cable, and the effectiveness of arrester protection. Low-side surges were found to consist of two basic components: the natural frequency of the system and the inductive response of the system to the stoke current. The latter component is responsible for transformer failures while the former may be responsible for discharge spots often found around secondary bushings. Arresters at the service entrance are effective in diverting most of the energy from a lightning strike, but may not protect sensitive loads. Additional local protection is also needed. The tests affirmed previous simulations and uncovered additional phenomena as well

Clinical patterns in Parkinson's disease

NARCIS (Netherlands)

Rooden, Stephanie Maria van

2012-01-01

The clinical heterogeneity of Parkinson’s disease (PD) patients may reflect the existence of subtypes of the disease. PD subtypes have often been defined by a classification according to researcher-specified criteria, such as age-at-onset or predominant clinical motor features. The general objective

Obsessive compulsive personality disorder and Parkinson's disease.

Science.gov (United States)

Nicoletti, Alessandra; Luca, Antonina; Raciti, Loredana; Contrafatto, Donatella; Bruno, Elisa; Dibilio, Valeria; Sciacca, Giorgia; Mostile, Giovanni; Petralia, Antonio; Zappia, Mario

2013-01-01

To evaluate the frequency of personality disorders in Parkinson's disease (PD) patients and in a group of healthy controls. Patients affected by PD diagnosed according to the United Kingdom Parkinson's disease Society Brain Bank diagnostic criteria and a group of healthy controls were enrolled in the study. PD patients with cognitive impairment were excluded from the study. Structured Clinical Interview for Personality Disorders-II (SCID-II) has been performed to evaluate the presence of personality disorders. Presence of personality disorders, diagnosed according to the DSM-IV, was confirmed by a psychiatric interview. Clinical and pharmacological data were also recorded using a standardized questionnaire. 100 PD patients (57 men; mean age 59.0 ± 10.2 years) and 100 healthy subjects (52 men; mean age 58.1 ± 11.4 years) were enrolled in the study. The most common personality disorder was the obsessive-compulsive personality disorder diagnosed in 40 PD patients and in 10 controls subjects (p-valuepersonality disorder recorded in 14 PD patients and 4 control subjects (p-value 0.02). Obsessive-compulsive personality disorder was also found in 8 out of 16 de novo PD patients with a short disease duration. PD patients presented a high frequency of obsessive-compulsive personality disorder that does not seem to be related with both disease duration and dopaminergic therapy.

Noradrenergic deficits in Parkinson's disease

DEFF Research Database (Denmark)

Nahimi, A.; Sommerauer, M.; Ostergaard, K.

2017-01-01

Objectives: In vitro studies suggest that noradrenergic projections from locus coeruleus to subcortical and cortical brain structures, e.g., thalamus, undergo severe neurodegeneration in Parkinson’s disease (PD). Loss of noradrenergic projections may alter oscillatory activity that in turn may...... be associated with cognitive decline. To test this hypothesis of the origin of cognitive decline in this disease, we used positron emission tomography (PET) to quantify the density of noradrenergic projections in groups of PD patients and healthy controls (HC), in combination with neuropsychological assessment...... with cognitive performance, independent of premorbid cognitive function or disease. PD patients had significant slowing of qEEG, e.g., the background alpha rhythm, but only EEG reactivity upon eye opening correlated with thalamic 11C-MeNER BPND in PD patients. Conclusion: This is the first direct quantification...

Typhoon Haiyan-Induced Storm Surge Simulation in Metro Manila Using High-Resolution LiDAR Topographic Data

Science.gov (United States)

Santiago, J. T.

2015-12-01

Storm surge is the abnormal rise in sea water over and above astronomical tides due to a forthcoming storm. Developing an early warning system for storm surges is vital due to the high level of hazard they might cause. On 08 November 2013, Typhoon Haiyan generated storm surges that killed over 6,000 people in the central part of the Philippines. The Nationwide Operational Assessment of Hazards under the Department of Science and Technology was tasked to create storm surge hazard maps for the country's coastal areas. The research project aims to generate storm surge hazard maps that can be used for disaster mitigation and planning. As part of the research, the team explored a scenario wherein a tropical cyclone hits the Metro Manila with strength as strong as Typhoon Haiyan. The area was chosen primarily for its political, economic and cultural significance as the country's capital. Using Japan Meteorological Agency Storm Surge model, FLO2D flooding software, LiDAR topographic data, and GIS technology, the effects of a Haiyan-induced tropical cyclone passing through Metro Manila was examined. The population affected, number of affected critical facilities, and potential evacuation sites were identified. The outputs of this study can be used by the authorities as basis for policies that involve disaster risk reduction and management.

The psychosis spectrum in Parkinson disease

Science.gov (United States)

ffytche, Dominic H.; Creese, Byron; Politis, Marios; Chaudhuri, K. Ray; Weintraub, Daniel; Ballard, Clive; Aarsland, Dag

2017-01-01

In 2007, the clinical and research profile of illusions, hallucinations, delusions and related symptoms in Parkinson disease (PD) was raised with the publication of a consensus definition of PD psychosis. Symptoms that were previously deemed benign and clinically insignificant were incorporated into a continuum of severity, leading to the rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. Here, we review this literature and the evolving view of PD psychosis. Key topics include the prospective risk of dementia in individuals with PD psychosis, and the causal and modifying effects of PD medication. We discuss recent developments, including recognition of an increase in the prevalence of psychosis with disease duration, addition of new visual symptoms to the psychosis continuum, and identification of frontal executive, visual perceptual and memory dysfunction at different disease stages. In addition, we highlight novel risk factors — for example, autonomic dysfunction — that have emerged from prospective studies, structural MRI evidence of frontal, parietal, occipital and hippocampal involvement, and approval of pimavanserin for the treatment of PD psychosis. The accumulating evidence raises novel questions and directions for future research to explore the clinical management and biomarker potential of PD psychosis. PMID:28106066

Impact of hydrogeological factors on groundwater salinization due to ocean-surge inundation

Science.gov (United States)

Yang, Jie; Zhang, Huichen; Yu, Xuan; Graf, Thomas; Michael, Holly A.

2018-01-01

Ocean surges cause seawater inundation of coastal inland areas. Subsequently, seawater infiltrates into coastal aquifers and threatens the fresh groundwater resource. The severity of resulting salinization can be affected by hydrogeological factors including aquifer properties and hydrologic conditions, however, little research has been done to assess these effects. To understand the impacts of hydrogeological factors on groundwater salinization, we numerically simulated an ocean-surge inundation event on a two-dimensional conceptual coastal aquifer using a coupled surface-subsurface approach. We varied model permeability (including anisotropy), inland hydraulic gradient, and recharge rate. Three salinization-assessment indicators were developed, based on flushing time, depth of salt penetration, and a combination of the two, weighted flushing time, with which the impact of hydrogeological factors on groundwater vulnerability to salinization were quantitatively assessed. The vulnerability of coastal aquifers increases with increasing isotropic permeability. Low horizontal permeability (kx) and high vertical permeability (kz) lead to high aquifer vulnerability, and high kx and low kz lead to low aquifer vulnerability. Vulnerability decreases with increasing groundwater hydraulic gradient and increasing recharge rate. Additionally, coastal aquifers with a low recharge rate (R ≤ 300 mm yr-1) may be highly vulnerable to ocean-surge inundation. This study shows how the newly introduced indicators can be used to quantitatively assess coastal aquifer vulnerability. The results are important for global vulnerability assessment of coastal aquifers to ocean-surge inundation.

Observed characteristics of tide-surge interaction along the east coast of India and the head of Bay of Bengal

Digital Repository Service at National Institute of Oceanography (India)

Antony, C.; Unnikrishnan, A.S.

before the high tide. Application of a simple model shows the observed surge peak distribution at Hiron Point can be explained in terms of phase alteration of tide due to surge and surge modulation by tide. The degree of interaction tends to increase...

Synopsis on the linkage of Alzheimer's and Parkinson's disease with chronic diseases.

Science.gov (United States)

Jabir, Nasimudeen R; Firoz, Chelapram K; Baeesa, Saleh S; Ashraf, Ghulam Md; Akhtar, Suhail; Kamal, Warda; Kamal, Mohammad A; Tabrez, Shams

2015-01-01

Neurodegeneration is the progressive loss of neuronal structure and function, which ultimately leads to neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis, and Huntington's disease. Even after the recent significant advances in neurobiology, the above-mentioned disorders continue to haunt the global population. Several studies have suggested the role of specific environmental and genetic risk factors associated with these disorders. However, the exact mechanism associated with the progression of these disorders still needs to be elucidated. In the recent years, sophisticated research has revealed interesting association of prominent neurodegenerative disorders such as AD and PD with chronic diseases such as cancer, diabetes, and cardiovascular diseases. Several common molecular mechanisms such as generation of free radicals, oxidative DNA damage, aberrations in mitochondrial DNA, and dysregulation of apoptosis have been highlighted as possible points of connection. The present review summarizes the possible mechanism of coexistence of AD and PD with other chronic diseases. © 2014 John Wiley & Sons Ltd.

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Ask Expert Briefings: Physical Therapy & PD: What You Need to Know Expert Briefings: What's Missing? Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Soy el compas de otra canción” Expert Briefings: Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal ...

Model-data comparisons of crevasses in accelerating glaciers exemplified for the 2011-2013 surge of Bering Glacier, Alaska

Science.gov (United States)

Trantow, T.; Herzfeld, U. C.

2017-12-01

Glacier acceleration, ubiquitous along the periphery of the major icesheets, presents one of the main uncertainties in modeling future global sea-level rise according to the IPCC 5th Assessment Report (2013). The surge phenomenon is one type of glacial acceleration and is the least understood. During a surge, large-scale elevation change and significant crevassing occurs throughout the entire ice system. Crevasses are the most obvious manifestations of the surge dynamics and provide a source of geophysical information that allows reconstruction of deformation processes. The recent surge of the Bering-Bagley Glacier System (BBGS), Alaska, in 2011-2013 provides an excellent test case to study surging through airborne and satellite observations together with numerical modeling. A 3D full-Stokes finite element model of the BBGS has been created using the Elmer/Ice software for structural and dynamical investigations of the surge. A von Mises condition is applied to modeled surface stresses to predict where crevassing would occur during the surge. The model uses CryoSat-2 derived surface topography (Baseline-C), bedrock topography, Glen's flow law with an isothermal assumption and a uniform linear friction law at the ice/bedrock boundary to represent the surge state in early 2011 when peak velocities were observed. Additionally, geostatistical characterization applied to optical satellite imagery provides an observational data set for model-data comparisons. Observed and modeled crevasse characteristics are compared with respect to their location, magnitude and orientation. Similarity mapping applied to the modeled von Mises stress and observed surface roughness values indicates that the two quantities are correlated. Results indicate that large-scale surface crevasses resulting from a surge are connected to the bedrock topography of the glacier system. The model-data comparisons used in this analysis serve to validate the numerical model and provide insight into the

Fluctuating attention in Parkinson's disease

DEFF Research Database (Denmark)

Starrfelt, Randi; Aarsland, Dag; Janvin, Carmen

2001-01-01

Lewy body dementia (DLB), which share many clinical and pathological features with Parkinson’s disease (PD), is charac- terised by marked fluctuations in cognition and consciousness. Fluctuating cognition has not been formally studied in PD, although some studies indicate that PD patients show...

Surge-like Oscillations above Sunspot Light Bridges Driven by Magnetoacoustic Shocks

Energy Technology Data Exchange (ETDEWEB)

Zhang, Jingwen; Tian, Hui; He, Jiansen; Wang, Linghua, E-mail: huitian@pku.edu.cn [School of Earth and Space Sciences, Peking University, 100871 Beijing (China)

2017-03-20

High-resolution observations of the solar chromosphere and transition region often reveal surge-like oscillatory activities above sunspot light bridges (LBs). These oscillations are often interpreted as intermittent plasma jets produced by quasi-periodic magnetic reconnection. We have analyzed the oscillations above an LB in a sunspot using data taken by the Interface Region Imaging Spectrograph . The chromospheric 2796 Å images show surge-like activities above the entire LB at any time, forming an oscillating wall. Within the wall we often see that the core of the Mg ii k 2796.35 Å line first experiences a large blueshift, and then gradually decreases to zero shift before increasing to a redshift of comparable magnitude. Such a behavior suggests that the oscillations are highly nonlinear and likely related to shocks. In the 1400 Å passband, which samples emission mainly from the Si iv ion, the most prominent feature is a bright oscillatory front ahead of the surges. We find a positive correlation between the acceleration and maximum velocity of the moving front, which is consistent with numerical simulations of upward propagating slow-mode shock waves. The Si iv 1402.77 Å line profile is generally enhanced and broadened in the bright front, which might be caused by turbulence generated through compression or by the shocks. These results, together with the fact that the oscillation period stays almost unchanged over a long duration, lead us to propose that the surge-like oscillations above LBs are caused by shocked p-mode waves leaked from the underlying photosphere.

Modeling the Origin and Possible Control of the Wealth Inequality Surge.

Science.gov (United States)

Berman, Yonatan; Shapira, Yoash; Ben-Jacob, Eshel

2015-01-01

The rapid increase of wealth inequality in the past few decades is a most disturbing social and economic issue of our time. In order to control, and even reverse that surge, its origin and underlying mechanisms should be revealed. One of the challenges in studying these mechanisms is to incorporate realistic individual dynamics in the population level in a self-consistent manner. Our theoretical approach meets the challenge by using interacting multi-agent master-equations to model the dynamics of wealth inequality. The model is solved using stochastic multi-agent iterated maps. Taking into account growth rate, return on capital, private savings and economic mobility, we were able to capture the historical dynamics of wealth inequality in the United States during the course of the 20th century. We show that the fraction of capital income in the national income and the fraction of private savings are the critical factors that govern the wealth inequality dynamics. In addition, we found that economic mobility plays a crucial role in wealth accumulation. Notably, we found that the major decrease in private savings since the 1980s could be associated primarily with the recent surge in wealth inequality and if nothing changes in this respect we predict further increase in wealth inequality in the future. However, the 2007-08 financial crisis brought an opportunity to restrain the wealth inequality surge by increasing private savings. If this trend continues, it may lead to prevention, and even reversing, of the ongoing inequality surge.

Assessment of the Great Lakes Marine Renewable Energy Resources: Characterizing Lake Erie Surge, Seiche and Waves

Science.gov (United States)

Farhadzadeh, A.; Hashemi, M. R.

2016-02-01

Lake Erie, the fourth largest in surface area, smallest in volume and shallowest among the Great Lakes is approximately 400 km long and 90 km wide. Short term lake level variations are due to storm surge generated by high winds and moving pressure systems over the lake mainly in the southwest-northeast direction, along the lakes longitudinal axis. The historical wave data from three active offshore buoys shows that significant wave height can exceed 5 m in the eastern and central basins. The long-term lake level data show that storm surge can reach up to 3 m in eastern Lake Erie. Owing its shallow depth, Lake Erie frequently experiences seiching motions, the low frequency oscillations that are initiated by storm surge. The seiches whose first mode of oscillations has a period of nearly 14.2 hours can last from several hours to days. In this study, the Lake Erie potential for power generation, primarily using storm surge and seiche and also waves are assessed. Given the cyclic lake level variations due to storm-induced seiching, a concept similar to that of tidal range development is utilized to assess the potential of storm surge and seiche energy harvesting mechanisms for power generation. In addition, wave energy resources of the Lake is characterized -. To achieve these objectives, the following steps are taken : (1) Frequency of occurrence for extreme storm surge and wave events is determined using extreme value analysis such as Peak-Over-Threshold method for the long-term water level and wave data; (2) Spatial and temporal variations of wave height, storm surge and seiche are characterized. The characterization is carried out using the wave and storm surge outputs from numerical simulation of a number of historical extreme events. The coupled ADCIRC and SWAN model is utilized for the modeling; (3) Assessment of the potentials for marine renewable power generation in Lake Erie is made. The approach can be extended to the other lakes in the Great Lakes region.

Impact of Cyclone Track Features and Tidal Phase Shift upon Surge Characteristics in the Bay of Bengal along the Bangladesh Coast

Directory of Open Access Journals (Sweden)

Mohammad Asad Hussain

2017-11-01

Full Text Available The impact of cyclone track features (e.g., cyclone translation speed, cyclone path and cyclone landfall crossing angle in combination with tidal phase shift upon surge characteristics have been investigated at the Bay of Bengal along the Bangladesh coast. A two-dimensional hydrodynamic model in a horizontal direction (2DH coupled with a storm-surge model has been employed for the study. Numerical experiments with three different cyclone translation speeds show that when the surge height is directly forced by the cyclonic wind speed especially within the RWM (Radius of Maximum Wind, faster translation speed produces reduced surge height as the cyclone gets less time to force the water. On the other hand, at locations outside the RMW, surge waves travel as a propagating long wave where higher surges are produced by faster moving cyclones. It is found that surge arrival times are more and more affected by tidal phase when cyclone translation speed is reduced. Analysis of seven hypothetical parallel cyclone paths show that local bathymetry and complex coastline configurations strongly influence the surge height and surge arrival time along the Bangladesh coast. From the analyses of cyclone landfall crossing angles at the Khulna and Chittagong coasts, it is observed that surge durations are the smallest at both the coasts when the coastline crossing angles are the smallest.

[Epidemiology and causes of Parkinson's disease].

Science.gov (United States)

Lill, C M; Klein, C

2017-04-01

Parkinson's disease (PD) is the second most common neurodegenerative disease and has a growing socioeconomic impact due to demographic changes in the industrial nations. There are several forms of PD, a fraction of which (parkinsonism including three autosomal dominantly (SNCA, LRRK2, VPS35) and three autosomal recessively inherited ones (Parkin, PINK1, DJ-1). In addition, there are a plethora of genes causing atypical forms of parkinsonism. In contrast, idiopathic PD is of a multifactorial nature. Genome-wide association studies have established a total of 26 genetic loci for this form of the disease; however, for most of these loci the underlying functional genetic variants have not yet been identified and the respective disease mechanisms remain unresolved. Furthermore, there are a number of environmental and life style factors that are associated with idiopathic PD. Exposure to pesticides and possibly a history of head trauma represent genuine risk factors. Other PD-associated factors, such as smoking and intake of coffee and alcohol may not represent risk factors per se and the cause-effect relationship has not yet been elucidated for most of these factors. A patient with a positive family history and/or an early age of disease onset should undergo counseling with respect to a possible monogenic form of the disease. Disease prediction based on genetic, environmental and life style factors is not yet possible for idiopathic PD and potential gene-specific therapies are currently in the development or early testing phase.

Thermal stratification and fatigue stress analysis for pressurizer surge line

International Nuclear Information System (INIS)

Yu Xiaofei; Zhang Yixiong

2011-01-01

Thermal stratification of pressurizer surge line induced by the inside fluid results in the global bending moments, local thermal stresses, unexpected displacements and support loadings of the pipe system. In order to avoid a costly three-dimensional computation, a combined 1D/2D technique has been developed and implemented to analyze the thermal stratification and fatigue stress of pressurize surge line of QINSHAN Phase II Extension Nuclear Power Project in this paper, using the computer codes SYSTUS and ROCOCO. According to the mechanical analysis results of stratification, the maximum stress and cumulative usage factor are obtained. The results indicate that the stress and fatigue intensity considering thermal stratification satisfies RCC-M criterion. (authors)

Liftoff of the 18 May 1980 surge of Mount St. Helens (USA) and the deposits left behind

Science.gov (United States)

Gardner, James E.; Andrews, Benjamin J.; Dennen, Robert

2017-01-01

The distance that ground-hugging pyroclastic density currents travel is limited partly by when they reverse buoyancy and liftoff into the atmosphere. It is not clear, however, what deposits are left behind by lofting flows. One current that was seen to liftoff was the surge erupted from Mount St. Helens on the morning of 18 May 1980. Before lofting, it had leveled a large area of thick forest (the blowdown zone). The outer edge of the devastated area—where trees were scorched but left standing (the scorched zone)—is where the surge is thought to have lifted off. Deposits in the outer parts of the blowdown and in the scorched zone were examined at 32 sites. The important finding is that the laterally moving surge traveled through the scorched zone, and hence, the change in tree damage does not mark the runout distance of the surge. Buoyancy reversal and liftoff are thus not preserved in the deposits where the surge lofted upwards. We propose, based on interpretation of eyewitness accounts and the impacts of the surge on trees and vehicles, that the surge consisted of a faster, dilute "overcurrent" and a slower "undercurrent," where most of the mass (and heat) was retained. Reasonable estimates for flow density and velocity show that dynamic pressure of the surge (i.e., its ability to topple trees) peaked near the base of the overcurrent. We propose that where the overcurrent began to liftoff, the height of peak dynamic pressure rose above the trees and stopped toppling them. The slower undercurrent continued forward, however, scorching trees, but lacked the dynamic pressure needed to topple them. Grain-size variations argue that it slowed from ˜30 m s-1 when it entered the scorched zone to ˜3 m s-1 at the far end.

InSAR Observations and Finite Element Modeling of Crustal Deformation Around a Surging Glacier, Iceland

Science.gov (United States)

Spaans, K.; Auriac, A.; Sigmundsson, F.; Hooper, A. J.; Bjornsson, H.; Pálsson, F.; Pinel, V.; Feigl, K. L.

2014-12-01

Icelandic ice caps, covering ~11% of the country, are known to be surging glaciers. Such process implies an important local crustal subsidence due to the large ice mass being transported to the ice edge during the surge in a few months only. In 1993-1995, a glacial surge occurred at four neighboring outlet glaciers in the southwestern part of Vatnajökull ice cap, the largest ice cap in Iceland. We estimated that ~16±1 km3 of ice have been moved during this event while the fronts of some of the outlet glaciers advanced by ~1 km.Surface deformation associated with this surge has been surveyed using Interferometric Synthetic Aperture Radar (InSAR) acquisitions from 1992-2002, providing high resolution ground observations of the study area. The data show about 75 mm subsidence at the ice edge of the outlet glaciers following the transport of the large volume of ice during the surge (Fig. 1). The long time span covered by the InSAR images enabled us to remove ~12 mm/yr of uplift occurring in this area due to glacial isostatic adjustment from the retreat of Vatnajökull ice cap since the end of the Little Ice Age in Iceland. We then used finite element modeling to investigate the elastic Earth response to the surge, as well as confirm that no significant viscoelastic deformation occurred as a consequence of the surge. A statistical approach based on Bayes' rule was used to compare the models to the observations and obtain an estimate of the Young's modulus (E) and Poisson's ratio (v) in Iceland. The best-fitting models are those using a one-kilometer thick top layer with v=0.17 and E between 12.9-15.3 GPa underlain by a layer with v=0.25 and E from 67.3 to 81.9 GPa. Results demonstrate that InSAR data and finite element models can be used successfully to reproduce crustal deformation induced by ice mass variations at Icelandic ice caps.Fig. 1: Interferograms spanning 1993 July 31 to 1995 June 19, showing the surge at Tungnaárjökull (Tu.), Skaftárjökull (Sk.) and S�

The Role of LRRK2 in Parkinson's Disease

NARCIS (Netherlands)

A. Di Fonzo (Alessio)

2009-01-01

textabstractThis thesis focuses on the role of the leucine rich repeat kinase 2 (LRRK2) gene in Parkinson’s disease (PD). PD is the second most frequent human neurodegenerative disorder after Alzheimer’s disease. The etiology of PD remains unknown in most cases, but several

30 CFR 77.209 - Surge and storage piles.

Science.gov (United States)

2010-07-01

... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface... a reclaiming area or in any other area at or near a surge or storage pile where the reclaiming...

Determining Storm Surge Return Periods: The Use of Evidence of Historic Events

DEFF Research Database (Denmark)

Madsen, Kristine S.; Sørensen, Carlo Sass; Schmith, Torben

for tide gauge measurements, with 120 years of data available for the calculations. However, the oldest of these tide gauge stations was set up after a major storm surge in 1872, and no events of similar severity have occurred since. Including the evidence of the historic events from the 18th century...... changes the return period statistics, with a best estimate of a 100 year event changing from 1.5 meters (Sørensen et al. 2013) to 2.6 [2.2 – 2.8] meters (present study) in Køge just south of Copenhagen. Thus, with the tide gauge-based statistics, the storm surge on January 4 2017 was a 100 year event......, but with the revised statistics using historic evidence, much larger events can be expected. Further, we assess the very large impact of sea level rise on the storm surge statistics. As an example, according to the official statistics of southern Copenhagen, the flooding of a present day 100 year event...

Qinshan phase II extension nuclear power project thermal stratification and fatigue stress analysis for pressurizer surge line

International Nuclear Information System (INIS)

Yu Xiaofei; Zhang Yixiong; Ai Honglei

2010-01-01

Thermal stratification of pressurizer surge line induced by the inside fluid brings on global bending moments, local thermal stresses, unexpected displacements and support loadings of the pipe system. In order to avoid a costly three-dimensional computation, a combined 1D/2D technique has been developed and implemented to analyze the thermal stratification and fatigue stress of pressurize surge line of QINSHAN Phase II Extension Nuclear Power Project in this paper, using the computer codes SYSTUS and ROCOCO. According to the mechanical analysis results of stratification, the maximum stress and cumulative usage factor, the loadings at connections of surge line to main pipe and RCP and the displacements of surge line at supports are obtained. (authors)

Postural control and freezing of gait in Parkinson's disease.

Science.gov (United States)

Schlenstedt, Christian; Muthuraman, Muthuraman; Witt, Karsten; Weisser, Burkhard; Fasano, Alfonso; Deuschl, Günther

2016-03-01

The relationship between freezing of gait (FOG) and postural instability in Parkinson's disease (PD) is unclear. We analyzed the impact of FOG on postural control. 31 PD patients with FOG (PD+FOG), 27 PD patients without FOG (PD-FOG) and 22 healthy control (HC) were assessed in the ON state. Postural control was measured with the Fullerton Advanced Balance (FAB) scale and with center of pressure (COP) analysis during quiet stance and maximal voluntary forward/backward leaning. The groups were balanced concerning age, disease duration and disease severity. PD+FOG performed significantly worse in the FAB scale (21.8 ± 5.8) compared to PD-FOG (25.6 ± 5.0) and HC (34.9 ± 2.4) (mean ± SD, p postural control asymmetry. PD+FOG have reduced postural control compared to PD-FOG and HC. Our results show a relationship between the anterior-posterior COP position during quiet stance and FOG. The COP shift towards posterior in PD+FOG leads to a restricted precondition to generate forward progression during gait initiation. This may contribute to the occurrence of FOG or might be a compensatory strategy to avoid forward falls. Copyright © 2015 Elsevier Ltd. All rights reserved.

Sustainability of the Peritoneal Dialysis-First Policy in Hong Kong.

Science.gov (United States)

Choy, Agnes Shin-Man; Li, Philip Kam-Tao

2015-01-01

In Hong Kong, the average annual cost of haemodialysis (HD) per patient is more than double of that of peritoneal dialysis (PD). As the number of patients with end-stage renal disease (ESRD) has surged, it has posed a great financial burden to the government and society. A PD-first policy has been implemented in Hong Kong for three decades based on its cost-effectiveness, and has achieved successful outcomes throughout the years. A successful PD-first policy requires medical expertise in PD, the support of dedicated staff and a well-designed patient training programme. Addressing patients' PD problems is the key to sustainability of the PD-first policy. In this article, we highlight three important groups of patients: those with frequent peritonitis, ultrafiltration failure or inadequate dialysis. Potential strategies to improve the outcomes of these groups will be discussed. Moreover, enhancing HD as back-up support and promoting organ transplantation are needed in order to maintain sustainability of the PD-first policy. © 2015 S. Karger AG, Basel.

Machine characteristics, system arrangement, driver and operation effects on surge of dynamic compressor in oil and gas plants

Energy Technology Data Exchange (ETDEWEB)

Almasi, Amin

2012-12-15

Working in the surge area will result in an unstable compressor operation, exposing the dynamic compressor (centrifugal compressor or axial compressor) to destructive stress, high vibration and other damaging effects. The destructive power of the surge is enormous, ranging from changes in clearances, which result in a penalty in the compressor efficiency, to destruction of parts leading to bearing, rotor or seal replacements. The effects of compressor characteristics, driver type, compressor accessories, vent valve, check valve, trip delay and operation details on surge events and anti-surge system designs are studied. A case study is also discussed. (orig.)

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... Program: Step by Step OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis Ask the Helpline: What ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... and Parkinson's Nurse: Webinars: Nursing Solutions: Recognizing the Impact of Genitourinary Symptoms in PD Expert Briefings: Is ... With Non-Parkinson's Disease Medications? What Is the Impact of PD Medications on Excessive Daytime Sleepiness? What ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... for PD Patients? Are There Any Ways to Control the Rate of Progression of the Disease? What ... 2 What Are Some Strategies to Improve the Quality of Community Care for PD Patients? Dra. Claudia ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... Managing Depression, Anxiety & Psychosis OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis Why We Walk at ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: Webinars: Nursing Solutions: Recognizing the ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... In Your Area Resources & Support PD Library Legal, Financial, & Insurance Matters Blog For Caregivers Living with Parkinson's ... Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... What Is the Helpline? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis How Does Speech Therapy ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... con todos los presentadores OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis Is Compulsive Behavior a ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert ... What Is a Movement Disorder Specialist? Are There Any Interactions With Non-Parkinson's Disease Medications? Dealing with ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nursing Solutions: Recognizing the Impact of ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... PD Library Search library Topic Type Expert Briefings: Marijuana and PD: What Do We Really Know? Nurse ... Have Similar Symptoms? How Does Parkinson's Disease Affect Memory? How Does Depression Affect the Patient's Family and ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... a Candidate for DBS? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis OHSU - Overview of Parkinson's ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... PD: What You Need to Know Expert Briefings: Cognition and PD: What You've Always Wanted to ... People with Parkinson's? How Does Parkinson's Disease Affect Memory? When and What Type of Treatment Is Initiated ...

A Cushing's syndrome patient's severe insomnia and morning blood pressure surge both improved after her left adrenal tumor resection.

Science.gov (United States)

Imaizumi, Yuki; Ibaraki, Ai; Asada, Satoshi; Tominaga, Mitsuhiro; Hayashi, Hiroyuki; Tsuchihashi, Takuya; Eguchi, Kazuo; Kario, Kazuomi; Taketomi, Akira

2016-12-01

Underlying mechanisms of the elevated risks of hypertension and cardiovascular disease (CVD) in Cushing's syndrome (CS) are unclear. We treated an adult woman with CS because of a cortisol-secreting adrenal tumor. After tumor resection, the 24-h blood pressure (BP) level improved from 156/91 to 131/84 mmHg; the morning BP surprisingly improved from 174/98 to 127/93 mmHg, although we reduced her antihypertensive medication. Her sleep quality (by the Pittsburgh Sleep Quality Index) improved from 7 to 2 points. Disturbed circadian BP rhythm is often observed in CS, but was reported only as altered nocturnal BP fall. This is the first report showing the disappearance of the morning BP surge evaluated by ambulatory BP monitoring with postsurgery sleep quality improvement. Poor-quality sleep, followed by exaggerated morning BP surge may thus be a cause of CS-related cardiovascular events. Sleep quality and BP circadian rhythm evaluations may clarify hypertension and high CVD risk in CS.

Storm surge in the Bay of Bengal and Arabian Sea: The problem and its prediction

Digital Repository Service at National Institute of Oceanography (India)

Dube, S.K.; Rao, A.D.; Sinha, P.C.; Murty, T.S.; Bahulayan, N.

to annual economic losses in these countries. Thus, the real time monitoring and warning of storm surge is of great concern for this region. The goal of this paper is to provide an overview of major aspects of the storm surge problem in the Bay of Bengal...

Influence of potential sea level rise on societal vulnerability to hurricane storm-surge hazards, Sarasota County, Florida

Science.gov (United States)

Frazier, Tim G.; Wood, Nathan; Yarnal, Brent; Bauer, Denise H.

2010-01-01

Although the potential for hurricanes under current climatic conditions continue to threaten coastal communities, there is concern that climate change, specifically potential increases in sea level, could influence the impacts of future hurricanes. To examine the potential effect of sea level rise on community vulnerability to future hurricanes, we assess variations in socioeconomic exposure in Sarasota County, FL, to contemporary hurricane storm-surge hazards and to storm-surge hazards enhanced by sea level rise scenarios. Analysis indicates that significant portions of the population, economic activity, and critical facilities are in contemporary and future hurricane storm-surge hazard zones. The addition of sea level rise to contemporary storm-surge hazard zones effectively causes population and asset (infrastructure, natural resources, etc) exposure to be equal to or greater than what is in the hazard zone of the next higher contemporary Saffir–Simpson hurricane category. There is variability among communities for this increased exposure, with greater increases in socioeconomic exposure due to the addition of sea level rise to storm-surge hazard zones as one progresses south along the shoreline. Analysis of the 2050 comprehensive land use plan suggests efforts to manage future growth in residential, economic and infrastructure development in Sarasota County may increase societal exposure to hurricane storm-surge hazards.

Falls in Parkinson's disease and Huntington's disease

NARCIS (Netherlands)

Grimbergen, Yvette Anna Maria

2012-01-01

Falls in Parkinson’s (PD) and Huntington’s disease (HD) are common. 50 % of moderately affected PD patients sustained two or more falls during a prospective follow-up of 6 months. During a 3 month period 40 % of HD patients reported one or more fall. Many falls resulted in minor injuries and 42 % of

Structure characterization of Pd/Co/Pd tri-layer films epitaxially grown on MgO single-crystal substrates

Energy Technology Data Exchange (ETDEWEB)

Tobari, Kousuke, E-mail: tobari@futamoto.elect.chuo-u.ac.jp; Ohtake, Mitsuru; Nagano, Katsumasa; Futamoto, Masaaki

2011-09-30

Pd/Co/Pd tri-layer films were prepared on MgO substrates of (001), (111), and (011) orientations at room temperature by ultra high vacuum rf magnetron sputtering. The detailed film structures around the Co/Pd and the Pd/Co interfaces are investigated by reflection high energy electron diffraction. Pd layers of (001){sub fcc}, (111){sub fcc}, and (011){sub fcc} orientations epitaxially grow on the respective MgO substrates. Strained fcc-Co(001) single-crystal layers are formed on the Pd(001){sub fcc} layers by accommodating the fairly large lattice mismatch between the Co and the Pd layers. On the Co layers,, Pd polycrystalline layers are formed. When Co films are formed on the Pd(111){sub fcc} and the Pd(011){sub fcc} layers, atomic mixing is observed around the Co/Pd interfaces and fcc-CoPd alloy phases are coexisting with Co crystals. The Co crystals formed on the Pd(111){sub fcc} layers consist of hcp(0001) + fcc(111) and Pd(111){sub fcc} epitaxial layers are formed on the Co layers. Co crystals epitaxially grow on the Pd(011){sub fcc} layers with two variants, hcp(11-bar 00) and fcc(111). On the Co layers, Pd(011){sub fcc} epitaxial layers are formed.

The motor and cognitive features of Parkinson's disease in patients with concurrent Gaucher disease over 2 years: a case series.

Science.gov (United States)

Collins, Lucy M; Williams-Gray, Caroline H; Morris, Elizabeth; Deegan, Patrick; Cox, Timothy M; Barker, Roger A

2018-05-29

We report the cognitive features and progression of Parkinson's disease (PD) in five patients with concurrent Gaucher disease. The patients presented at an earlier age than patients with sporadic PD, as previously noted by others; but in contrast to many previous reports, our patients followed a variable clinical course. While two patients developed early cognitive deficits and dementia, three others remained cognitively intact over the follow-up period. Thus, in this small case series, PD in the context of GD more closely resembles idiopathic PD in terms of its clinical heterogeneity in contrast to PD associated with GBA heterozygote mutations.

Validation of hospital register-based diagnosis of Parkinson's disease

DEFF Research Database (Denmark)

Wermuth, Lene; Lassen, Christina Funch; Himmerslev, Liselotte

2012-01-01

Denmark has a long-standing tradition of maintaining one of the world's largest health science specialized register data bases as the National Hospital Register (NHR). To estimate the prevalence and incidence of diseases, the correctness of the diagnoses recorded is critical. Parkinson's disease...... (PD) is a neurodegenerative disorder and only 75-80% of patients with parkinsonism will have idiopathic PD (iPD). It is necessary to follow patients in order to determine if some of them will develop other neurodegenerative diseases and a one-time-only diagnostic code for iPD reported in the register...

PD Lab

NARCIS (Netherlands)

Bilow, Marcel; Entrop, Alexis Gerardus; Lichtenberg, Jos; Stoutjesdijk, Pieter

2015-01-01

PD Lab explores the applications of building sector related product development. PD lab investigates and tests digital production technologies like CNC milled wood connections. It will also act as a platform in its wider meaning to investigate the effects and influences of file to factory

Investigating unexpected magnetism of mesoporous silica-supported Pd and PdO nanoparticles

KAUST Repository

Song, Hyon Min; Zink, Jeffrey I.; Khashab, Niveen M.

2015-01-01

supported Pd and PdO NPs. The heating rate and the annealing conditions determine the particle size and the phase of the NPs, with a fast heating rate of 30 °C/min producing the largest supported Pd NPs. Unusual magnetic behaviors are observed. (1) Contrary

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nurse Webinars: Nursing Solutions: Innovations in PD Nurse Education CareMAP: Managing Advanced Parkinson's Website Nurse Webinars: Nursing ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Side Effect of PD Medications? CareMAP: Challenges and Rewards of Caregiving Why Dance for PD? What Are ... Caregivers How Does Parkinson's Disease Affect the Urinary System? How Can Caregivers Help with Freezing Episodes? OHSU - ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... a Brother: Donna’s Story OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: ... Therapeutic Approaches for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 What Is the Progression ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: ... Expert Briefings: Depression and PD: Treatment Options CareMAP: Travel and Transportation: Part 2 Ask the Helpline: What ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Education on Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and ... for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 Ask the Helpline: Why Is Exercise ...

An Investigation of Surge in a High-Speed Centrifugal Compressor Using Digital PIV

Science.gov (United States)

Wernet, Mark P.; Bright, Michelle M.; Skoch, Gary J.

2002-01-01

Compressor stall is a catastrophic breakdown of the flow in a compressor, which can lead to a loss of engine power, large pressure transients in the inlet/nacelle and engine flameout. The implementation of active or passive strategies for controlling rotating stall and surge can significantly extend the stable operating range of a compressor without substantially sacrificing performance. It is crucial to identify the dynamic changes occurring in the flow field prior to rotating stall and surge in order to successfully control these events. Generally, pressure transducer measurements are made to capture the transient response of a compressor prior to rotating stall. In this investigation, Digital Particle Imaging Velocimetry (DPIV) is used in conjunction with dynamic pressure transducers to simultaneously capture transient velocity and pressure measurements in the non-stationary flow field during compressor surge. DPIV is an instantaneous, planar measurement technique which is ideally suited for studying transient flow phenomena in high speed turbomachinery and has been used previously to successfully map the stable operating point flow field in the diffuser of a high speed centrifugal compressor. Through the acquisition of both DPIV images and transient pressure data, the time evolution of the unsteady flow during surge is revealed.

Cytotoxicity of Pd nanostructures supported on PEN: Influence of sterilization on Pd/PEN interface

Energy Technology Data Exchange (ETDEWEB)

Polívková, M., E-mail: polivkoa@vscht.cz [Department of Solid State Engineering, University of Chemistry and Technology Prague, 166 28 Prague (Czech Republic); Siegel, J. [Department of Solid State Engineering, University of Chemistry and Technology Prague, 166 28 Prague (Czech Republic); Rimpelová, S. [Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague (Czech Republic); Hubáček, T. [Institute of Hydrobiology, Biology Centre of the AS CR, 370 05 Ceske Budejovice (Czech Republic); Kolská, Z. [Materials Centre of Usti n. L., J.E. Purkyne University, 400 96 Usti nad Labem (Czech Republic); Švorčík, V. [Department of Solid State Engineering, University of Chemistry and Technology Prague, 166 28 Prague (Czech Republic)

2017-01-01

Non-conventional antimicrobial agents, such as palladium nanostructures, have been increasingly used in the medicinal technology. However, experiences uncovering their harmful and damaging effects to human health have begun to appear. In this study, we have focused on in vitro cytotoxicity assessment of Pd nanostructures supported on a biocompatible polymer. Pd nanolayers of variable thicknesses (ranging from 1.1 to 22.4 nm) were sputtered on polyethylene naphthalate (PEN). These nanolayers were transformed by low-temperature post-deposition annealing into discrete nanoislands. Samples were characterized by AFM, XPS, ICP-MS and electrokinetic analysis before and after annealing. Sterilization of samples prior to cytotoxicity testing was done by UV irradiation, autoclave and/or ethanol. Among the listed sterilization techniques, we have chosen the gentlest one which had minimal impact on sample morphology, Pd dissolution and overall Pd/PEN interface quality. Cytotoxic response of Pd nanostructures was determined by WST-1 cell viability assay in vitro using three model cell lines: mouse macrophages (RAW 264.7) and two types of mouse embryonic fibroblasts (L929 and NIH 3T3). Finally, cell morphology in response to Pd/PEN was evaluated by means of fluorescence microscopy. - Highlights: • Annealing of Pd nanolayers on PEN resulted to Pd aggregation and formation of discrete nanoislands. • UV treatment was found as the gentlest sterilization method in term of physicochemical properties of Pd/PEN interface. • Autoclaving and chemical sterilization by ethanol resulted into remarkable changes of Pd/PEN interface. • Cytotoxicity of Pd samples was insignificant. • Pd nanostructures are potentially applicable as health-unobjectionable antibacterial coatings of medical devices.

P-glycoprotein mediated efflux limits the transport of the novel anti-Parkinson's disease candidate drug FLZ across the physiological and PD pathological in vitro BBB models.

Directory of Open Access Journals (Sweden)

Qian Liu

Full Text Available FLZ, a novel anti-Parkinson's disease (PD candidate drug, has shown poor blood-brain barrier (BBB penetration based on the pharmacokinetic study using rat brain. P-glycoprotein (P-gp and breast cancer resistance protein (BCRP are two important transporters obstructing substrates entry into the CNS as well as in relation to PD neuropathology. However, it is unclear whether P-gp and BCRP are involved in low BBB permeability of FLZ and what the differences of FLZ brain penetration are between normal and Parkinson's conditions. For this purpose, in vitro BBB models mimicking physiological and PD pathological-related BBB properties were constructed by C6 astroglial cells co-cultured with primary normal or PD rat cerebral microvessel endothelial cells (rCMECs and in vitro permeability experiments of FLZ were carried out. High transepithelial electrical resistance (TEER and low permeability for sodium fluorescein (NaF confirmed the BBB functionality of the two models. Significantly greater expressions of P-gp and BCRP were detected in PD rCMECs associated with the lower in vitro BBB permeability of FLZ in pathological BBB model compared with physiological model. In transport studies only P-gp blocker effectively inhibited the efflux of FLZ, which was consistent with the in vivo permeability data. This result was also confirmed by ATPase assays, suggesting FLZ is a substrate for P-gp but not BCRP. The present study first established in vitro BBB models reproducing PD-related changes of BBB functions in vivo and demonstrated that poor brain penetration of FLZ and low BBB permeability were due to the P-gp transport.

Predicting typhoon-induced storm surge tide with a two-dimensional hydrodynamic model and artificial neural network model

Science.gov (United States)

Chen, W.-B.; Liu, W.-C.; Hsu, M.-H.

2012-12-01

Precise predictions of storm surges during typhoon events have the necessity for disaster prevention in coastal seas. This paper explores an artificial neural network (ANN) model, including the back propagation neural network (BPNN) and adaptive neuro-fuzzy inference system (ANFIS) algorithms used to correct poor calculations with a two-dimensional hydrodynamic model in predicting storm surge height during typhoon events. The two-dimensional model has a fine horizontal resolution and considers the interaction between storm surges and astronomical tides, which can be applied for describing the complicated physical properties of storm surges along the east coast of Taiwan. The model is driven by the tidal elevation at the open boundaries using a global ocean tidal model and is forced by the meteorological conditions using a cyclone model. The simulated results of the hydrodynamic model indicate that this model fails to predict storm surge height during the model calibration and verification phases as typhoons approached the east coast of Taiwan. The BPNN model can reproduce the astronomical tide level but fails to modify the prediction of the storm surge tide level. The ANFIS model satisfactorily predicts both the astronomical tide level and the storm surge height during the training and verification phases and exhibits the lowest values of mean absolute error and root-mean-square error compared to the simulated results at the different stations using the hydrodynamic model and the BPNN model. Comparison results showed that the ANFIS techniques could be successfully applied in predicting water levels along the east coastal of Taiwan during typhoon events.

Serum Bicarbonate And Survival In Peritoneal Dialysis (Pd: Comparison With Hemodialysis (Hd

Directory of Open Access Journals (Sweden)

Tania Sharma

2012-06-01

Full Text Available Correction of metabolic acidosis is one of the goals of effective dialysis. The KDOQI guidelines recommend serum bicarbonate >22 meq/L irrespective of dialysis modality. Since the measured bicarbonate reflects the steady state in PD patients and the lowest inter-dialytic value in HD patients, we compared the survival predictability of serum bicarbonate 10,400 PD and 110,951 HD patients treated in DaVita facilities from 7/2001-6/2006 with follow-up through 6/2007. PD patients were substantially less likely to have lower serum bicarbonate (adjusted odds, 22 meq/L for all end-stage renal disease irrespective of dialysis modality.fx1

The patients’ perspective: Results of a survey assessing knowledge about and attitudes toward depression in PD

Directory of Open Access Journals (Sweden)

Irene Hegeman Richard

2007-01-01

Full Text Available Irene Hegeman Richard1, Kori A LaDonna1, Rosanne Hartman2, Carol Podgorski1, Roger Kurlan1, SAD-PD Study Group31University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; 2Canisius College, Buffalo, NY, USA; 3Please see Appendix for members of the SAD-PD Study GroupAbstract: We report results of a survey assessing patients’ knowledge about and attitudes towards depression in Parkinson’s disease (PD. 345 patients from 8 tertiary care centers responded (43% response rate. Overall, patients were relatively knowledgeable about depression and its occurrence in PD. However, many patients believed that depression is a normal reaction to the illness. While many respondents would be reluctant to initiate a discussion of depression during a clinical evaluation, most would feel comfortable talking about depression with their physician if he or she asked them questions about their mood. Based on the results of this survey, we recommend the following approach for physicians: (1 inform PD patients that, although a frequent occurrence, depression need not be accepted as a “normal reaction” to PD; and (2 routinely inquire about depressive symptoms rather than waiting for the patient to spontaneously report them.Keywords: depression, Parkinson’s disease, survey

Aqueous phase hydrogenation of phenol catalyzed by Pd and PdAg on ZrO 2

Energy Technology Data Exchange (ETDEWEB)

Resende, Karen A.; Hori, Carla E.; Noronha, Fabio B.; Shi, Hui; Gutierrez, Oliver Y.; Camaioni, Donald M.; Lercher, Johannes A.

2017-11-01

Hydrogenation of phenol in aqueous phase was studied over a series of ZrO2-supported Pd catalysts in order to explore the effects of particle size and of Ag addition on the activity of Pd. Kinetic assessments were performed in a batch reactor, on monometallic Pd/ZrO2 samples with different Pd loadings (0.5%, 1% and 2%), as well as on a 1% PdAg/ZrO2 sample. The turnover frequency (TOF) increases with the Pd particle size. The reaction orders in phenol and H2 indicate that the surface coverages by phenol, H2 and their derived intermediates are higher on 0.5% Pd/ZrO2 than on other samples. The activation energy was the lowest on the least active sample (0.5% Pd/ZrO2), while being identical on 1% and 2% Pd/ZrO2 catalysts. Thus, the significantly lower activity of the small Pd particles (1-2 nm on average) in 0.5%Pd/ZrO2 is explained by the unfavorable activation entropies for the strongly bound species. The presence of Ag increases considerably the TOF of the reaction by decreasing the Ea and increasing the coverages of phenol and H2.

Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan

International Nuclear Information System (INIS)

Liao, C.-M.; Liang, H.-M.; Chen, B.-C.; Singh Sher; Tsai, J.-W.; Chou, Y.-H.; Lin, W.-T.

2005-01-01

A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models were developed for arsenic (As) in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. The PBPK/PD model structure consisted of muscle, gill, gut wall, alimentary canal, and liver, which were interconnected by blood circulation. We integrate the target organ concentrations and dynamic response describing uptake, metabolism, and disposition of As and the associated area-under-curve (AUC)-based toxicological dynamics following an acute exposure. The model validations were compared against the field observations from real tilapia farms and previously published uptake/depuration experimental data, indicating that predicted and measured As concentrations in major organs of tilapia were in good agreement. The model was utilized to reasonably simulate and construct a dose-dependent dynamic response between mortality effect and equilibrium target organ concentrations. Model simulations suggest that tilapia gills may serve as a surrogate sensitive biomarker of short-term exposure to As. This integrated As PBPK/PD/AUC model quantitatively estimates target organ concentration and dynamic response in tilapia and is a strong framework for future waterborne metal model development and for refining a biologically-based risk assessment for exposure of aquatic species to waterborne metals under a variety of scenarios. - Integrated toxicity models can identify dynamic responses of fish to arsenic

Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan

Energy Technology Data Exchange (ETDEWEB)

Liao, C.-M. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China)]. E-mail: cmliao@ntu.edu.tw; Liang, H.-M. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China); Chen, B.-C. [Department of Post-Modern Agriculture, Mingdao University, Changhua, Taiwan 52345 (China); Singh Sher [Center of Genomics Medicine, School of Medicine, National Taiwan University, Taipei, Taiwan 10617 (China); Tsai, J.-W. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China); Chou, Y.-H. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China); Lin, W.-T. [Environment Change Research Center, Academia Sinica, Nankang, Taipei, Taiwan 11517 (China)

2005-05-01

A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models were developed for arsenic (As) in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. The PBPK/PD model structure consisted of muscle, gill, gut wall, alimentary canal, and liver, which were interconnected by blood circulation. We integrate the target organ concentrations and dynamic response describing uptake, metabolism, and disposition of As and the associated area-under-curve (AUC)-based toxicological dynamics following an acute exposure. The model validations were compared against the field observations from real tilapia farms and previously published uptake/depuration experimental data, indicating that predicted and measured As concentrations in major organs of tilapia were in good agreement. The model was utilized to reasonably simulate and construct a dose-dependent dynamic response between mortality effect and equilibrium target organ concentrations. Model simulations suggest that tilapia gills may serve as a surrogate sensitive biomarker of short-term exposure to As. This integrated As PBPK/PD/AUC model quantitatively estimates target organ concentration and dynamic response in tilapia and is a strong framework for future waterborne metal model development and for refining a biologically-based risk assessment for exposure of aquatic species to waterborne metals under a variety of scenarios. - Integrated toxicity models can identify dynamic responses of fish to arsenic.

Airway somatosensory deficits and dysphagia in Parkinson's disease.

Science.gov (United States)

Hammer, Michael J; Murphy, Caitlin A; Abrams, Trisha M

2013-01-01

Individuals with Parkinson's disease (PD) often experience substantial impairment of swallow control, and are typically unaware of the presence or severity of their impairments suggesting that these individuals may also experience airway sensory deficits. However, the degree to which impaired swallow function in PD may relate to airway sensory deficits has yet to be formally tested. The purpose of this study was to examine whether airway sensory function is associated with swallow impairment in PD. Eighteen PD participants and 18 healthy controls participated in this study and underwent endoscopic assessment of airway somatosensory function, endoscopic assessment of swallow function, and clinical ratings of swallow and disease severity. PD participants exhibited abnormal airway somatosensory function and greater swallow impairment compared with healthy controls. Swallow and sensory deficits in PD were correlated with disease severity. Moreover, PD participants reported similar self-rated swallow function as healthy controls, and swallow deficits were correlated with sensory function suggesting an association between impaired sensory function and poor self-awareness of swallow deficits in PD. These results suggest that control of swallow is influenced by airway somatosensory function, that swallow-related deficits in PD are related to abnormal somatosensation, and that swallow and airway sensory function may degrade as a function of disease severity. Therefore, the basal ganglia and related neural networks may play an important role to integrate airway sensory input for swallow-related motor control. Furthermore, the airway deficits observed in PD suggest a disintegration of swallow-related sensory and motor control.

Reading comprehension in Parkinson's disease.

Science.gov (United States)

Murray, Laura L; Rutledge, Stefanie

2014-05-01

Although individuals with Parkinson's disease (PD) self-report reading problems and experience difficulties in cognitive-linguistic functions that support discourse-level reading, prior research has primarily focused on sentence-level processing and auditory comprehension. Accordingly, the authors investigated the presence and nature of reading comprehension in PD, hypothesizing that (a) individuals with PD would display impaired accuracy and/or speed on reading comprehension tests and (b) reading performances would be correlated with cognitive test results. Eleven adults with PD and 9 age- and education-matched control participants completed tests that evaluated reading comprehension; general language and cognitive abilities; and aspects of attention, memory, and executive functioning. The PD group obtained significantly lower scores on several, but not all, reading comprehension, language, and cognitive measures. Memory, language, and disease severity were significantly correlated with reading comprehension for the PD group. Individuals in the early stages of PD without dementia or broad cognitive deficits can display reading comprehension difficulties, particularly for high- versus basic-level reading tasks. These reading difficulties are most closely related to memory, high-level language, and PD symptom severity status. The findings warrant additional research to delineate further the types and nature of reading comprehension impairments experienced by individuals with PD.

[The role of patient flow and surge capacity for in-hospital response in mass casualty events].

Science.gov (United States)

Sefrin, Peter; Kuhnigk, Herbert

2008-03-01

Mass casualty events make demands on emergency services and disaster control. However, optimized in- hospital response defines the quality of definitive care. Therefore, German federal law governs the role of hospitals in mass casualty incidents. In hospital casualty surge is depending on resources that have to be expanded with a practicable alarm plan. Thus, in-hospital mass casualty management planning is recommended to be organized by specialized persons. To minimise inhospital patient overflow casualty surge principles have to be implemented in both, pre-hospital and in-hospital disaster planning. World soccer championship 2006 facilitated the initiation of surge and damage control principles in in-hospital disaster planning strategies for German hospitals. The presented concept of strict control of in-hospital patient flow using surge principles minimises the risk of in-hospital breakdown and increases definitive hospital treatment capacity in mass casualty incidents.

From cyclic ice streaming to Heinrich-like events: the grow-and-surge instability in the Parallel Ice Sheet Model

Directory of Open Access Journals (Sweden)

J. Feldmann

2017-08-01

Full Text Available >Here we report on a cyclic, physical ice-discharge instability in the Parallel Ice Sheet Model, simulating the flow of a three-dimensional, inherently buttressed ice-sheet-shelf system which periodically surges on a millennial timescale. The thermomechanically coupled model on 1 km horizontal resolution includes an enthalpy-based formulation of the thermodynamics, a nonlinear stress-balance-based sliding law and a very simple subglacial hydrology. The simulated unforced surging is characterized by rapid ice streaming through a bed trough, resulting in abrupt discharge of ice across the grounding line which is eventually calved into the ocean. We visualize the central feedbacks that dominate the subsequent phases of ice buildup, surge and stabilization which emerge from the interaction between ice dynamics, thermodynamics and the subglacial till layer. Results from the variation of surface mass balance and basal roughness suggest that ice sheets of medium thickness may be more susceptible to surging than relatively thin or thick ones for which the surge feedback loop is damped. We also investigate the influence of different basal sliding laws (ranging from purely plastic to nonlinear to linear on possible surging. The presented mechanisms underlying our simulations of self-maintained, periodic ice growth and destabilization may play a role in large-scale ice-sheet surging, such as the surging of the Laurentide Ice Sheet, which is associated with Heinrich events, and ice-stream shutdown and reactivation, such as observed in the Siple Coast region of West Antarctica.

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... la Deglución, Parte 2 OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nurse Webinars: Nursing Solutions: Innovations in PD Nurse Education CareMAP: Managing ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... library Topic Type Living Alone: Home Safety and Management in PD Expert Briefings: Marijuana and PD: What ... la Deglución, Parte 2 OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis Caregiver Summit 2016: The ...

Structural genomic variations and Parkinson's disease.

Science.gov (United States)

Bandrés-Ciga, Sara; Ruz, Clara; Barrero, Francisco J; Escamilla-Sevilla, Francisco; Pelegrina, Javier; Vives, Francisco; Duran, Raquel

2017-10-01

Parkinson's disease (PD) is the second most common neurodegenerative disease, whose prevalence is projected to be between 8.7 and 9.3 million by 2030. Until about 20 years ago, PD was considered to be the textbook example of a "non-genetic" disorder. Nowadays, PD is generally considered a multifactorial disorder that arises from the combination and complex interaction of genes and environmental factors. To date, a total of 7 genes including SNCA, LRRK2, PARK2, DJ-1, PINK 1, VPS35 and ATP13A2 have been seen to cause unequivocally Mendelian PD. Also, variants with incomplete penetrance in the genes LRRK2 and GBA are considered to be strong risk factors for PD worldwide. Although genetic studies have provided valuable insights into the pathogenic mechanisms underlying PD, the role of structural variation in PD has been understudied in comparison with other genomic variations. Structural genomic variations might substantially account for such genetic substrates yet to be discovered. The present review aims to provide an overview of the structural genomic variants implicated in the pathogenesis of PD.

Influence of Northeast Monsoon cold surges on air quality in Southeast Asia

Science.gov (United States)

Ashfold, M. J.; Latif, M. T.; Samah, A. A.; Mead, M. I.; Harris, N. R. P.

2017-10-01

Ozone (O3) is an important ground-level pollutant. O3 levels and emissions of O3 precursors have increased significantly over recent decades in East Asia and export of this O3 eastward across the Pacific Ocean is well documented. Here we show that East Asian O3 is also transported southward to tropical Southeast (SE) Asia during the Northeast Monsoon (NEM) season (defined as November to February), and that this transport pathway is especially strong during 'cold surges'. Our analysis employs reanalysis data and measurements from surface sites in Peninsular Malaysia, both covering 2003-2012, along with trajectory calculations. Using a cold surge index (northerly winds at 925 hPa averaged over 105-110°E, 5°N) to define sub-seasonal strengthening of the NEM winds, we find the largest changes in a region covering much of the Indochinese Peninsula and surrounding seas. Here, the levels of O3 and another key pollutant, carbon monoxide, calculated by the Monitoring Atmospheric Composition and Climate (MACC) Reanalysis are on average elevated by, respectively, >40% (∼15 ppb) and >60% (∼80 ppb) during cold surges. Further, in the broader region of SE Asia local afternoon exceedances of the World Health Organization's air quality guideline for O3 (100 μg m-3, or ∼50 ppb, averaged over 8 h) largely occur during these cold surges. Day-to-day variations in available O3 observations at surface sites on the east coast of Peninsular Malaysia and in corresponding parts of the MACC Reanalysis are similar, and are clearly linked to cold surges. However, observed O3 levels are typically ∼10-20 ppb lower than the MACC Reanalysis. We show that these observations are also subject to influence from local urban pollution. In agreement with past work, we find year-to-year variations in cold surge activity related to the El Nino-Southern Oscillation (ENSO), but this does not appear to be the dominant influence of ENSO on atmospheric composition in this region. Overall, our study

Neurokinin-3 Receptor Activation in the Retrochiasmatic Area is Essential for the Full Preovulatory LH Surge in Ewes

Science.gov (United States)

Porter, Katrina L.; Hileman, Stanley M.; Hardy, Steven L.; Nestor, Casey C; Lehman, Michael N.; Goodman, Robert L.

2014-01-01

Neurokinin B (NKB) is essential for human reproduction and has been shown to stimulate LH secretion in several species, including sheep. Ewes express the neurokinin-3 receptor (NK3R) in the retrochiasmatic area (RCh) and there is one report that placement of senktide, an NK3R agonist, therein stimulates LH secretion that resembles an LH surge in ewes. In this study, we first confirmed that local administration of senktide to the RCh produced a surge-like increase in LH secretion, and then tested the effects of this agonist in two other areas implicated in the control of LH secretion and where NK3R is found in high abundance: the preoptic area (POA) and arcuate nucleus (ARC). Bilateral microimplants containing senktide induced a dramatic surge-like increase in LH when given in the POA similar to that seen with RCh treatment. In contrast, senktide treatment in the ARC resulted in a much smaller, but significant, increase in LH concentrations suggestive of an effect on tonic secretion. The possible role of POA and RCh NK3R activation in the LH surge was next tested by treating ewes with SB222200, an NK3R antagonist, in each area during an E2-induced LH surge. SB222200 in the RCh, but not in the POA, reduced LH surge amplitude by about 40% compared to controls, indicating that NK3R activation in the former region is essential for full expression of the preovulatory LH surge. Based on these data, we propose that NKB actions in the RCh are an important component of the preovulatory LH surge in ewes. PMID:25040132

High-temperature stability of Au/Pd/Cu and Au/Pd(P)/Cu surface finishes

Science.gov (United States)

Ho, C. E.; Hsieh, W. Z.; Lee, P. T.; Huang, Y. H.; Kuo, T. T.

2018-03-01

Thermal reliability of Au/Pd/Cu and Au/Pd(4-6 wt.% P)/Cu trilayers in the isothermal annealing at 180 °C were investigated by X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectrometry (TOF-SIMS), and transmission electron microscopy (TEM). The pure Pd film possessed a nanocrystalline structure with numerous grain boundaries, thereby facilitating the interdiffusion between Au and Cu. Out-diffusion of Cu through Pd and Au grain boundaries yielded a significant amount of Cu oxides (CuO and Cu2O) over the Au surface and gave rise to void formation in the Cu film. By contrast, the Pd(P) film was amorphous and served as a good diffusion barrier against Cu diffusion. The results of this study indicated that amorphous Pd(P) possessed better oxidation resistance and thermal reliability than crystalline Pd.

Biomarker Research in Parkinson's Disease Using Metabolite Profiling

DEFF Research Database (Denmark)

Havelund, Jesper F; Heegaard, Niels H H; Færgeman, Nils J K

2017-01-01

Biomarker research in Parkinson's disease (PD) has long been dominated by measuring dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do not allow early detection, precise prognosis or monitoring of disease progression. Moreover, PD is now considered a multifa......) and purine metabolism (uric acid) are also altered in most metabolite profiling studies in PD......., the potential as a biomarker and the significance of understanding the pathophysiology of PD. Many of the studies report alterations in alanine, branched-chain amino acids and fatty acid metabolism, all pointing to mitochondrial dysfunction in PD. Aromatic amino acids (phenylalanine, tyrosine, tryptophan...

MIS gas sensors based on porous silicon with Pd and WO{sub 3}/Pd electrodes

Energy Technology Data Exchange (ETDEWEB)

Solntsev, V.S. [Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028, Kiev (Ukraine); Gorbanyuk, T.I., E-mail: tatyanagor@mail.r [Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028, Kiev (Ukraine); Litovchenko, V.G.; Evtukh, A.A. [Institute of Semiconductor Physics, National Academy of Science of Ukraine, 03028, Kiev (Ukraine)

2009-09-30

Pd and WO{sub 3}/Pd gate metal-oxide-semiconductor (MIS) gas sensitive structures based on porous silicon layers are studied by the high frequency C(V) method. The chemical compositions of composite WO{sub 3}/Pd electrodes are characterized by secondary-ion mass spectrometry (SIMS). The atomic force microscopy (AFM) was used for morphologic studies of WO{sub 3}/Pd films. As shown in the experiments, WO{sub 3}/Pd structures are more sensitive and selective to the adsorption of hydrogen sulphide compared to Pd gate. The analyses of kinetic characteristics allow us to determine the response and characteristic times for these structures. The response time of MIS-structures with thin composite WO{sub 3}/Pd electrodes (the thickness of Pd is about 50 nm with WO{sub 3} clusters on its surface) is slower compared to the structures with Pd electrodes. Slower sensor responses of WO{sub 3}-based gas sensors may be associated with different mechanism of gas sensitivity of given structures. The enhanced sensitivity and selectivity to H{sub 2}S action of WO{sub 3}/Pd MIS-structures can also be explained by the chemical reaction that occurs at the catalytic active surface of gate electrodes. The possible mechanisms of enhanced sensitivity and selectivity to H{sub 2}S adsorption of MIS gas sensors with WO{sub 3}/Pd composite gate electrodes compared to pure Pd have been analyzed.

Surge and selection: power in the refugee resettlement regime

OpenAIRE

Annelisa Lindsay

2017-01-01

There is an imbalance of power – and a resulting lack of agency for refugees – in the structure of the current resettlement regime. The top-down process of selection also poses ethical dilemmas, as recent surges in resettlement operations show.

What is measured with verbal fluency tests in Parkinson's disease patients at different stages of the disease?

NARCIS (Netherlands)

Koerts, Janneke; Meijer, Hester A.; Colman, Katrien S. F.; Tucha, Lara; Lange, Klaus W.; Tucha, Oliver

Verbal fluency tests (VFT) are often used to assess executive functioning in Parkinson's disease (PD). Various cognitive functions may, however, impair performance on VFT. Furthermore, since PD is a progressive neurodegenerative disease, it is also not clear whether deficits on VFT reflect

Corticomuscular coherence during hand gripping with DBS and medication in PD patients

DEFF Research Database (Denmark)

Sridharan, Kousik Sarathy; Højlund, Andreas; Johnsen, Erik Lisbjerg

Deep brain stimulation (DBS) effectively alleviates the motor symptoms in Parkinson’s disease (PD) although its effect mechanism is still unclear. CMC is reduced in PD patients but restorable with medication, while DBS variably affects CMC in advanced PD patients. We recorded magnetoencephalography...... (MEG) from six PD patients performing hand gripping during DBS ON and medicated (levodopa, MED ON) conditions and from ten age-matched healthy controls. Participants performed isotonic contractions (hand gripping) with their right hand, and electromyography (EMG) was recorded from the extensor...... digitorum communis muscle with a belly-tendon montage. We calculated the mean-squared coherence between MEG and the rectified EMG signals. For each group and condition, we selected the maximum CMC value in the beta range (13-30 Hz) within the average of an a priori selection of nine left sensorimotor...

One-pot synthesis of Pd-Pt@Pd core-shell nanocrystals with enhanced electrocatalytic activity for formic acid oxidation

KAUST Repository

Yuan, Qiang; Huang, Dabing; Wang, Honghui; Zhou, Zhiyou; Wang, Qingxiao

2014-01-01

Well-defined Pd-Pt@Pd core-shell nanocrystals with a Pd-Pt alloy core and a conformal Pd shell of ~2-3 nm were directly synthesized through a one-pot, aqueous solution approach without any preformed Pd or Pt seeds. These Pd-Pt@Pd core

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert ... Common Misconceptions About Parkinson's Disease? CareMAP: Life Beyond This Life CareMAP: El Baño, Parte 2 What Are ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... and Scheduling: Part 2 What Are the Common Sleep Disorders Encountered in Patients with PD? CareMAP: Planear y ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: ... Therapeutic Approaches for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 CareMAP: Bathroom: Part 1 ¿ ...

Parkinson's Disease Videos

Medline Plus

Full Text Available ... Education on Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and ... for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 CareMAP: Bathroom: Part 1 ¿Cómo Se ...

Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort

Directory of Open Access Journals (Sweden)

Morgadinho Ana S

2006-07-01

Full Text Available Abstract Background Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer (AD and Parkinson diseases (PD. Iron metabolism is associated with the gene hemochromatosis (HFE Human genome nomenclature committee ID:4886, and mutations in HFE are a cause of the iron mismetabolism disease, hemochromatosis. Several reports have tested the association of HFE variants with neurodegenerative diseases, such as AD and PD with conflicting results. Methods Genotypes were analysed for the two most common variants of HFE in a series of 130 AD, 55 Mild Cognitive Impairment (MCI and 132 PD patients. Additionally, a series of 115 healthy age-matched controls was also screened. Results A statistically significant association was found in the PD group when compared to controls, showing that the presence of the C282Y variant allele may confer higher risk for developing the disease. Conclusion Taken together these results suggest that the common variants in HFE may be a risk factor for PD, but not for AD in the Portuguese population.

Motor Sequence Learning Performance in Parkinson's Disease Patients Depends on the Stage of Disease

Science.gov (United States)

Stephan, Marianne A.; Meier, Beat; Zaugg, Sabine Weber; Kaelin-Lang, Alain

2011-01-01

It is still unclear, whether patients with Parkinson's disease (PD) are impaired in the incidental learning of different motor sequences in short succession, although such a deficit might greatly impact their daily life. The aim of this study was thus to clarify the relation between disease parameters of PD and incidental motor learning of two…

Evaluation of surge transferred overvoltages in distribution transformers

NARCIS (Netherlands)

Popov, M.; Sluis, van der L.; Smeets, R.P.P.

2008-01-01

The paper presents an analysis of very fast-transient overvoltages that occur because of the capacitive surge transfer from the high-voltage (HV) transformer winding to the low-voltage (LV) transformer winding. The study is done on a 6.6 kV single-phase test transformer. By applying a pulse with a

Genetic predisposition to Parkinson's disease

DEFF Research Database (Denmark)

Halling, Jónrit; Petersen, Maria Skaalum; Grandjean, Philippe

2008-01-01

OBJECTIVE: To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased. METHODS: Blood samples were collected from 79 PD patients and 154...

A Two-Step Method to Select Major Surge-Producing Extratropical Cyclones from a 10,000-Year Stochastic Catalog

Science.gov (United States)

Keshtpoor, M.; Carnacina, I.; Yablonsky, R. M.

2016-12-01

Extratropical cyclones (ETCs) are the primary driver of storm surge events along the UK and northwest mainland Europe coastlines. In an effort to evaluate the storm surge risk in coastal communities in this region, a stochastic catalog is developed by perturbing the historical storm seeds of European ETCs to account for 10,000 years of possible ETCs. Numerical simulation of the storm surge generated by the full 10,000-year stochastic catalog, however, is computationally expensive and may take several months to complete with available computational resources. A new statistical regression model is developed to select the major surge-generating events from the stochastic ETC catalog. This regression model is based on the maximum storm surge, obtained via numerical simulations using a calibrated version of the Delft3D-FM hydrodynamic model with a relatively coarse mesh, of 1750 historical ETC events that occurred over the past 38 years in Europe. These numerically-simulated surge values were regressed to the local sea level pressure and the U and V components of the wind field at the location of 196 tide gauge stations near the UK and northwest mainland Europe coastal areas. The regression model suggests that storm surge values in the area of interest are highly correlated to the U- and V-component of wind speed, as well as the sea level pressure. Based on these correlations, the regression model was then used to select surge-generating storms from the 10,000-year stochastic catalog. Results suggest that roughly 105,000 events out of 480,000 stochastic storms are surge-generating events and need to be considered for numerical simulation using a hydrodynamic model. The selected stochastic storms were then simulated in Delft3D-FM, and the final refinement of the storm population was performed based on return period analysis of the 1750 historical event simulations at each of the 196 tide gauges in preparation for Delft3D-FM fine mesh simulations.

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

Directory of Open Access Journals (Sweden)

Xian-Si Zeng

2018-04-01

Full Text Available It has been 200 years since Parkinson disease (PD was described by Dr. Parkinson in 1817. The disease is the second most common neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although the pathogenesis of PD is still unknown, the research findings from scientists are conducive to understand the pathological mechanisms. It is well accepted that both genetic and environmental factors contribute to the onset of PD. In this review, we summarize the mutations of main seven genes (α-synuclein, LRRK2, PINK1, Parkin, DJ-1, VPS35 and GBA1 linked to PD, discuss the potential mechanisms for the loss of dopaminergic neurons (dopamine metabolism, mitochondrial dysfunction, endoplasmic reticulum stress, impaired autophagy, and deregulation of immunity in PD, and expect the development direction for treatment of PD.

Surge of Hispar Glacier, Pakistan, between 2013 and 2017 detected from remote sensing observations

Science.gov (United States)

Rashid, Irfan; Abdullah, Tariq; Glasser, Neil F.; Naz, Heena; Romshoo, Shakil Ahmad

2018-02-01

This study analyses the behaviour of an actively surging glacier, Hispar, in Pakistan using remote sensing methods. We used 15 m panchromatic band of Landsat 8 OLI from 2013 to 2017 to assess the changes in glacier velocity, glacier geomorphology and supraglacial water bodies. For the velocity estimation, correlation image analysis (CIAS) was used, which is based on normalized cross-correlation (NCC) of satellite data. On-screen digitization was employed to quantify changes in the glacier geomorphology and dynamics of supraglacial water bodies on the glacier. Our velocity estimates indicate that the upper part of the glacier is presently undergoing an active surge which not only affects the debris distribution but also impacts the development of supraglacial water bodies. Velocities in the actively surging part of the main glacier trunk and its three tributaries reach up to 900 m yr- 1. The surge of Hispar also impacts the distribution of supraglacial debris causing folding of the medial moraines features present on the glacier surface. Changes in the number and size of supraglacial lakes and ponds were also observed during the observation period from 2013 to 2017.

Mortality in patients with Parkinson's disease

DEFF Research Database (Denmark)

Wermuth, L; Stenager, E; Stenager, E

1995-01-01

INTRODUCTION: After the introduction of L-dopa the mortality rate in Parkinson's disease (PD) patients has changed, but is still higher than in the background population. MATERIAL & METHODS: Mortality, age at death and cause of death in a group of PD patients compared with the background population....... In the background population the median age at death was 80.69 years for men and 84.37 years for women. The SMR for men was 1.92 and for women 2.47. Infections, in particular lung infections, and heart diseases were the most common causes of death. Seventy percent of the death certificates had PD as a diagnosis....... CONCLUSION: It is likely that several factors can influence the changed mortality of PD: more effective treatment, changing diagnostic practice, and inter-disease competition....

Monitoring Hurricane Rita Inland Storm Surge: Chapter 7J in Science and the storms-the USGS response to the hurricanes of 2005

Science.gov (United States)

McGee, Benton D.; Tollett, Roland W.; Goree, Burl B.

2007-01-01

Pressure transducers (sensors) are accurate, reliable, and cost-effective tools to measure and record the magnitude, extent, and timing of hurricane storm surge. Sensors record storm-surge peaks more accurately and reliably than do high-water marks. Data collected by sensors may be used in storm-surge models to estimate when, where, and to what degree stormsurge flooding will occur during future storm-surge events and to calibrate and verify stormsurge models, resulting in a better understanding of the dynamics of storm surge.

Postural inflexibility in PD: does it affect compensatory stepping?

NARCIS (Netherlands)

Smulders, K.; Esselink, R.A.J.; Swart, B.J.M. de; Geurts, A.C.H.; Bloem, B.R.; Weerdesteyn, V.G.M.

2014-01-01

Parkinson's disease (PD) impairs the ability to shape postural responses to contextual factors. It is unknown whether such inflexibility pertains to compensatory steps to overcome balance perturbations. Participants were instructed to recover balance in response to a platform translation. A step was

Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance.

Science.gov (United States)

Martin, A M; Nirschl, T R; Nirschl, C J; Francica, B J; Kochel, C M; van Bokhoven, A; Meeker, A K; Lucia, M S; Anders, R A; DeMarzo, A M; Drake, C G

2015-12-01

Primary prostate cancers are infiltrated with programmed death-1 (PD-1) expressing CD8+ T-cells. However, in early clinical trials, men with metastatic castrate-resistant prostate cancer did not respond to PD-1 blockade as a monotherapy. One explanation for this unresponsiveness could be that prostate tumors generally do not express programmed death ligand-1 (PD-L1), the primary ligand for PD-1. However, lack of PD-L1 expression in prostate cancer would be surprising, given that phosphatase and tensin homolog (PTEN) loss is relatively common in prostate cancer and several studies have shown that PTEN loss correlates with PD-L1 upregulation--constituting a mechanism of innate immune resistance. This study tested whether prostate cancer cells were capable of expressing PD-L1, and whether the rare PD-L1 expression that occurs in human specimens correlates with PTEN loss. Human prostate cancer cell lines were evaluated for PD-L1 expression and loss of PTEN by flow cytometry and western blotting, respectively. Immunohistochemical (IHC) staining for PTEN was correlated with PD-L1 IHC using a series of resected human prostate cancer samples. In vitro, many prostate cancer cell lines upregulated PD-L1 expression in response to inflammatory cytokines, consistent with adaptive immune resistance. In these cell lines, no association between PTEN loss and PD-L1 expression was apparent. In primary prostate tumors, PD-L1 expression was rare, and was not associated with PTEN loss. These studies show that some prostate cancer cell lines are capable of expressing PD-L1. However, in human prostate cancer, PTEN loss is not associated with PD-L1 expression, arguing against innate immune resistance as a mechanism that mitigates antitumor immune responses in this disease.

Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease

Directory of Open Access Journals (Sweden)

Laura Ibanez

2018-04-01

Full Text Available Background: The prevalence of dementia in Parkinson disease (PD increases dramatically with advancing age, approaching 80% in patients who survive 20 years with the disease. Increasing evidence suggests clinical, pathological and genetic overlap between Alzheimer disease, dementia with Lewy bodies and frontotemporal dementia with PD. However, the contribution of the dementia-causing genes to PD risk, cognitive impairment and dementia in PD is not fully established.Objective: To assess the contribution of coding variants in Mendelian dementia-causing genes on the risk of developing PD and the effect on cognitive performance of PD patients.Methods: We analyzed the coding regions of the amyloid-beta precursor protein (APP, Presenilin 1 and 2 (PSEN1, PSEN2, and Granulin (GRN genes from 1,374 PD cases and 973 controls using pooled-DNA targeted sequence, human exome-chip and whole-exome sequencing (WES data by single variant and gene base (SKAT-O and burden tests analyses. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE or the Montreal Cognitive Assessment (MoCA. The effect of coding variants in dementia-causing genes on cognitive performance was tested by multiple regression analysis adjusting for gender, disease duration, age at dementia assessment, study site and APOE carrier status.Results: Known AD pathogenic mutations in the PSEN1 (p.A79V and PSEN2 (p.V148I genes were found in 0.3% of all PD patients. There was a significant burden of rare, likely damaging variants in the GRN and PSEN1 genes in PD patients when compared with frequencies in the European population from the ExAC database. Multiple regression analysis revealed that PD patients carrying rare variants in the APP, PSEN1, PSEN2, and GRN genes exhibit lower cognitive tests scores than non-carrier PD patients (p = 2.0 × 10−4, independent of age at PD diagnosis, age at evaluation, APOE status or recruitment site.Conclusions: Pathogenic mutations in

Magnetic characteristics of CoPd and FePd antidot arrays on nanoperforated Al_2O_3 templates

International Nuclear Information System (INIS)

Maximenko, A.; Fedotova, J.; Marszałek, M.; Zarzycki, A.; Zabila, Y.

2016-01-01

Hard magnetic antidot arrays show promising results in context of designing of percolated perpendicular media. In this work the technology of magnetic FePd and CoPd antidot arrays fabrication is presented and correlation between surface morphology, structure and magnetic properties is discussed. CoPd and FePd antidot arrays were fabricated by deposition of Co/Pd and Fe/Pd multilayers (MLs) on porous anodic aluminum oxide templates with bowl-shape cell structure with inclined intercellular regions. FePd ordered L1_0 structure was obtained by successive vacuum annealing at elevated temperatures (530 °C) and confirmed by XRD analysis. Systematic analysis of magnetization curves evidenced perpendicular magnetic anisotropy of CoPd antidot arrays, while FePd antidot arrays revealed isotropic magnetic anisotropy with increased out-of-plane magnetic contribution. MFM images of antidots showed more complicated contrast, with alternating magnetic dots oriented parallel and antiparallel to tip magnetization moment. - Highlights: • CoPd and FePd antidots were fabricated on porous anodic aluminum oxide templates. • CoPd antidot arrays have perpendicular magnetic anisotropy. • FePd antidot arrays revealed isotropic magnetic behavior. • The complex morphology of nanoporous template resulted in a complex magnetic domains image.

Effects of cluster land reclamation projects on storm surge in Jiaojiang Estuary, China

Directory of Open Access Journals (Sweden)

Zhi-lin Sun

2017-01-01

Full Text Available Variations in coastline geometry caused by coastal engineering affect tides, storm surges, and storm tides. Three cluster land reclamation projects have been planned for construction in the Jiaojiang Estuary during the period from 2011 to 2023. They will cause significant changes in coastline geometry. In this study, a surge-tide coupled model was established based on a three-dimensional finite-volume coastal ocean model (FVCOM. A series of numerical experiments were carried out to investigate the effects of variations in coastline geometry on tides, storm surges, and storm tides. This model was calibrated using data observed at the Haimen and Ruian gauge stations and then used to reproduce the tides, storm surges, and storm tides in the Jiaojiang Estuary caused by Typhoon Winnie in 1997. Results show that the high tide level, peak storm surge, and high storm tide level at the Haimen Gauge Station increased along with the completion of reclamation projects, and the maximum increments caused by the third project were 0.13 m, 0.50 m, and 0.43 m, respectively. The envelopes with maximum storm tide levels of 7.0 m and 8.0 m inside the river mouth appeared to move seaward, with the latter shifting 1.8 km, 3.3 km, and 4.4 km due to the first project, second project, and third project, respectively. The results achieved in this study contribute to reducing the effects of, and preventing storm disasters after the land reclamation in the Jiaojiang Estuary.

Using wind setdown and storm surge on Lake Erie to calibrate the air-sea drag coefficient.

Science.gov (United States)

Drews, Carl

2013-01-01

The air-sea drag coefficient controls the transfer of momentum from wind to water. In modeling storm surge, this coefficient is a crucial parameter for estimating the surge height. This study uses two strong wind events on Lake Erie to calibrate the drag coefficient using the Coupled Ocean Atmosphere Wave Sediment Transport (COAWST) modeling system and the the Regional Ocean Modeling System (ROMS). Simulated waves are generated on the lake with Simulating WAves Nearshore (SWAN). Wind setdown provides the opportunity to eliminate wave setup as a contributing factor, since waves are minimal at the upwind shore. The study finds that model results significantly underestimate wind setdown and storm surge when a typical open-ocean formulation without waves is used for the drag coefficient. The contribution of waves to wind setdown and storm surge is 34.7%. Scattered lake ice also increases the effective drag coefficient by a factor of 1.1.

Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients with EGFR-Mutant Non-small Cell Lung Cancer.

Science.gov (United States)

Cho, Jong Ho; Zhou, Wei; Choi, Yoon-La; Sun, Jong-Mu; Choi, Hyejoo; Kim, Tae-Eun; Dolled-Filhart, Marisa; Emancipator, Kenneth; Rutkowski, Mary Anne; Kim, Jhingook

2018-01-01

Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor ( EGFR )-mutant non-small cell lung cancer (NSCLC). We retrospectively evaluated the relationship between PD-L1 expression and recurrence-free survival (RFS) and overall survival in 319 patients with EGFR -mutant NSCLC who were treated at Samsung Medical Center from 2006 to 2014. Membranous PD-L1 expression on tumor cells was measured using the PD-L1 IHC 22C3 pharmDx antibody and reported as tumor proportion score (TPS). Kaplan-Meier methods, log-rank test, and Cox proportional hazards models were used for survival analysis. All patients had ≥1 EGFR mutation-54% in exon 19 and 39% in exon 21. Overall, 51% of patients had PD-L1-positive tumors. The prevalence of PD-L1 positivity was higher among patients with stages II-IV versus stage I disease (64% vs. 44%) and among patients with other EGFR mutations (75%) than with L858R mutation (39%) or exon 19 deletion (52%). PD-L1 positivity was associated with shorter RFS, with an adjusted hazard ratio of 1.52 (95% confidence interval [CI], 0.81 to 2.84; median, 18 months) for the PD-L1 TPS ≥ 50% group, 1.51 (95% CI, 1.02 to 2.21; median, 31 months) for the PD-L1 TPS 1%-49% group, and 1.51 (95% CI, 1.05 to 2.18) for the combined PD-L1-positive groups (TPS ≥ 1%) compared with the PD-L1-negative group (median, 35 months). PD-L1 expression is associated with disease stage and type of EGFR mutation. PD-L1 positivity might be associated with worse RFS among patients with surgically treated EGFR -mutant NSCLC.

Model simulation of storm surge potential for Andaman islands

Digital Repository Service at National Institute of Oceanography (India)

Kumar, V.S.; RameshBabu, V.; Babu, M.T.; Dhinakaran, G.; Rajamanickam, G.V.

Hydraulics and Oceanography, the Hydrodynamics Module Reference Manual. DHI Water and Environment, Horsholm, Denmark, 58 p. Dube, S.K., Sinha, P C , Rao, A.D., and Rao, G.S., 1985. Numerical modeling of storm surges in the Arabian Sea, Appl. Math Modelling, 9...

One-pot synthesis of Pd-Pt@Pd core-shell nanocrystals with enhanced electrocatalytic activity for formic acid oxidation

KAUST Repository

Yuan, Qiang

2014-01-01

Well-defined Pd-Pt@Pd core-shell nanocrystals with a Pd-Pt alloy core and a conformal Pd shell of ~2-3 nm were directly synthesized through a one-pot, aqueous solution approach without any preformed Pd or Pt seeds. These Pd-Pt@Pd core-shell nanocrystals show an enhanced electrocatalytic activity for formic acid oxidation compared with commercial Pd black. This journal is © 2014 The Royal Society of Chemistry.

Surge capacity principles: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement.

Science.gov (United States)

Hick, John L; Einav, Sharon; Hanfling, Dan; Kissoon, Niranjan; Dichter, Jeffrey R; Devereaux, Asha V; Christian, Michael D

2014-10-01

This article provides consensus suggestions for expanding critical care surge capacity and extension of critical care service capabilities in disasters or pandemics. It focuses on the principles and frameworks for expansion of intensive care services in hospitals in the developed world. A companion article addresses surge logistics, those elements that provide the capability to deliver mass critical care in disaster events. The suggestions in this article are important for all who are involved in large-scale disasters or pandemics with injured or critically ill multiple patients, including front-line clinicians, hospital administrators, and public health or government officials. The Surge Capacity topic panel developed 23 key questions focused on the following domains: systems issues; equipment, supplies, and pharmaceuticals; staffing; and informatics. Literature searches were conducted to identify evidence on which to base key suggestions. Most reports were small scale, were observational, or used flawed modeling; hence, the level of evidence on which to base recommendations was poor and did not permit the development of evidence-based recommendations. Therefore, the panel developed expert opinion-based suggestions using a modified Delphi process. Suggestions from the previous task force were also included for validation by the expert panel. This article presents 10 suggestions pertaining to the principles that should guide surge capacity and capability planning for mass critical care, including the role of critical care in disaster planning; the surge continuum; targets of surge response; situational awareness and information sharing; mitigating the impact on critical care; planning for the care of special populations; and service deescalation/cessation (also considered as engineered failure). Future reports on critical care surge should emphasize population-based outcomes as well as logistical details. Planning should be based on the projected number of

Parkinson's Disease Videos

Medline Plus

Full Text Available ... A A You are here Home PD Library Search library Topic Type Expert Briefings: Marijuana and PD: What Do We Really Know? Nurse Webinars: Nursing Solutions: Improving Caregiver Strain through Science and Model Interventions Expert Briefings: Parkinson's Disease Psychosis: ...

Risks of Coastal Storm Surge and the Effect of Sea Level Rise in the Red River Delta, Vietnam

Directory of Open Access Journals (Sweden)

James E. Neumann

2015-05-01

Full Text Available This paper considers the impact of sea level rise and storm surge on the Red River delta region of Vietnam. Permanently inundated lands and temporary flood zones are analyzed by combining sea level rise scenarios for 2050 with simulated storm surge levels for the 100-year event. Our analysis finds that sea level rise through 2050 could increase the effective frequency of the current 100-year storm surge, which is associated with a storm surge of roughly five meters, to once every 49 years. Approximately 10% of the Hanoi region’s GDP is vulnerable to permanent inundation due to sea level rise, and more than 40% is vulnerable to periodic storm surge damage consistent with the current 100-year storm. We conclude that coastal adaptation measures, such as a planned retreat from the sea, and construction of a more substantial seawall and dike system, are needed to respond to these threats.

Control of Pierce's Disease by Phage.

Directory of Open Access Journals (Sweden)

Mayukh Das

Full Text Available Pierce's Disease (PD of grapevines, caused by Xylella fastidiosa subsp. fastidiosa (Xf, is a limiting factor in the cultivation of grapevines in the US. There are presently no effective control methods to prevent or treat PD. The therapeutic and prophylactic efficacy of a phage cocktail composed of four virulent (lytic phages was evaluated for control of PD. Xf levels in grapevines were significantly reduced in therapeutically or prophylactically treated grapevines. PD symptoms ceased to progress one week post-therapeutic treatment and symptoms were not observed in prophylactically treated grapevines. Cocktail phage levels increased in grapevines in the presence of the host. No in planta phage-resistant Xf isolates were obtained. Moreover, Xf mutants selected for phage resistance in vitro did not cause PD symptoms. Our results indicate that phages have great potential for biocontrol of PD and other economically important diseases caused by Xylella.

Parkinson’s disease managing reversible neurodegeneration

Directory of Open Access Journals (Sweden)

Hinz M

2016-04-01

Full Text Available Marty Hinz,1 Alvin Stein,2 Ted Cole,3 Beth McDougall,4 Mark Westaway5 1Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, 2Stein Orthopedic Associates, Plantation, FL, 3Cole Center for Healing, Cincinnati, OH, 4CLEARCenter of Health, Mill Valley, CA, USA; 5Four Pillars Health, Brendale, QLD, Australia Abstract: Traditionally, the Parkinson’s disease (PD symptom course has been classified as an irreversible progressive neurodegenerative disease. This paper documents 29 PD and treatment-induced systemic depletion etiologies which cause and/or exacerbate the seven novel primary relative nutritional deficiencies associated with PD. These reversible relative nutritional deficiencies (RNDs may facilitate and accelerate irreversible progressive neurodegeneration, while other reversible RNDs may induce previously undocumented reversible pseudo-neurodegeneration that is hiding in plain sight since the symptoms are identical to the symptoms being experienced by the PD patient. Documented herein is a novel nutritional approach for reversible processes management which may slow or halt irreversible progressive neurodegenerative disease and correct reversible RNDs whose symptoms are identical to the patient’s PD symptoms. Keywords: Parkinson’s disease, L-dopa, carbidopa, B6, neurodegeneration

Bladder dysfunction in advanced Parkinson's disease

DEFF Research Database (Denmark)

Winge, Kristian; Nielsen, Kurt K

2012-01-01

Parkinson's disease (PD) patients often have lower urinary tract symptoms. Seventy-four percent of patients with early-to-moderate disease report more than one bladder disturbance symptom. Severe bladder symptoms are reported in 27-39% of PD patients. The aim of this study was to evaluate...

Automating Flood Hazard Mapping Methods for Near Real-time Storm Surge Inundation and Vulnerability Assessment

Science.gov (United States)

Weigel, A. M.; Griffin, R.; Gallagher, D.

2015-12-01

Storm surge has enough destructive power to damage buildings and infrastructure, erode beaches, and threaten human life across large geographic areas, hence posing the greatest threat of all the hurricane hazards. The United States Gulf of Mexico has proven vulnerable to hurricanes as it has been hit by some of the most destructive hurricanes on record. With projected rises in sea level and increases in hurricane activity, there is a need to better understand the associated risks for disaster mitigation, preparedness, and response. GIS has become a critical tool in enhancing disaster planning, risk assessment, and emergency response by communicating spatial information through a multi-layer approach. However, there is a need for a near real-time method of identifying areas with a high risk of being impacted by storm surge. Research was conducted alongside Baron, a private industry weather enterprise, to facilitate automated modeling and visualization of storm surge inundation and vulnerability on a near real-time basis. This research successfully automated current flood hazard mapping techniques using a GIS framework written in a Python programming environment, and displayed resulting data through an Application Program Interface (API). Data used for this methodology included high resolution topography, NOAA Probabilistic Surge model outputs parsed from Rich Site Summary (RSS) feeds, and the NOAA Census tract level Social Vulnerability Index (SoVI). The development process required extensive data processing and management to provide high resolution visualizations of potential flooding and population vulnerability in a timely manner. The accuracy of the developed methodology was assessed using Hurricane Isaac as a case study, which through a USGS and NOAA partnership, contained ample data for statistical analysis. This research successfully created a fully automated, near real-time method for mapping high resolution storm surge inundation and vulnerability for the