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Sample records for disease pd surg

  1. The PD-1/PD-Ls pathway and autoimmune diseases.

    Science.gov (United States)

    Dai, Suya; Jia, Ru; Zhang, Xiao; Fang, Qiwen; Huang, Lijuan

    2014-07-01

    The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, is a new member of the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273). Recently, it is reported that PD-1, PD-L1 and PD-L2 also have soluble forms aside from their membrane bound forms. The soluble forms increase the diversity and complexity of PD-1/PD-Ls pathway in both composition and function. The PD-1/PD-Ls pathway is broadly expressed and exerts a wider range of immunoregulatory roles in T-cell activation and tolerance compared with other B7/CD28 family members. Studies show that the PD-1/PD-Ls pathway regulates the induction and maintenance of peripheral tolerance and protects tissues from autoimmune attack in physiological conditions. In addition, it is also involved in various diseases mediated by T cells, such as autoimmunity, tumor immunity, chronic viral infections, and transplantation immunity. In this review, we will summarize the relevance of the soluble forms and the latest researches on the role of PD-1/PD-Ls pathway in autoimmune diseases. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Morning Blood Pressure Surge as a Predictor of Development of Chronic Kidney Disease.

    Science.gov (United States)

    Turak, Osman; Afsar, Baris; Siriopol, Dimitrie; Ozcan, Firat; Cagli, Kumral; Yayla, Cagri; Oksuz, Fatih; Mendi, Mehmet Ali; Kario, Kazuomi; Covic, Adrian; Kanbay, Mehmet

    2016-05-01

    Blood pressure (BP) usually increases upon awakening--a physiological mechanism called morning BP surge (MBPS). BP values above the MBPS threshold are associated with target organ damage, including left ventricular hypertrophy and proteinuria. Despite these data, there have been no studies that have investigated the association between elevated MBPS and the development of incident chronic kidney disease (CKD). In this study, patients with essential hypertension were included and underwent ambulatory BP measurements and MBPS. Patients were followed for a median of 3.33 years. In total, 622 patients were enrolled. The mean age of patients was 57.6±12.4 years, 54.0% were men, 16.7% had diabetes, and 10.6% had prevalent cardiovascular disease. During follow-up, 32 patients developed CKD. Higher MBPS, analyzed both as continuous and categorical variables, was associated with incident CKD in all models. Elevated MBPS is associated with kidney function deterioration and the development of CKD. Studies are needed to further examine underlying mechanisms regarding MBPS and these renal outcomes. © 2015 Wiley Periodicals, Inc.

  3. Surges in proteinuria are associated with plasma GL-3 elevations in a young patient with classic Fabry disease.

    Science.gov (United States)

    Kanai, Takahiro; Ito, Takane; Odaka, Jun; Saito, Takashi; Aoyagi, Jun; Betsui, Hiroyuki; Yamagata, Takanori

    2016-03-01

    Fabry disease is an X-linked glycosphingolipidosis caused by deficient synthesis of the enzyme α-galactosidase A, which results in accumulations of globotriaosylceramide (GL-3) in systemic tissues. Nephropathy is a dominant feature of Fabry disease. It still remains unclear how the nephropathy progresses. Recombinant agalsidase replacement therapy is currently the only approved, specific therapy for Fabry disease. The optimal dose of replacement enzyme also still remains unclear. The worldwide shortage of agalsidase-β in 2009 forced dose reduction of administration. It showed that the proteinuria emerged like surges, followed by temporary plasma GL-3 elevations in the early stages of classic Fabry disease. Additionally, it also showed that 1 mg/kg of agalsidase-β every other week could clear the GL-3 accumulations from podocytes and was required to maintain negative proteinuria and normal plasma GL-3 levels. This observation of a young patient with classic Fabry disease about 5 years reveals that the long-term, low-dose agalsidase-β caused proteinuria surges, but not persistent proteinuria, followed by temporary plasma GL-3 elevations, and agalsidase-β at 1 mg/kg every other week could clear accumulated GL-3 from podocytes and was required to maintain normal urinalysis and plasma GL-3 levels.

  4. Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm.

    Science.gov (United States)

    Rao, Martin; Valentini, Davide; Dodoo, Ernest; Zumla, Alimuddin; Maeurer, Markus

    2017-03-01

    Immune checkpoint pathways regulate optimal host immune responses against transformed cells, induce immunological memory, and limit tissue pathology. Conversely, aberrant immune checkpoint activity signifies a poor prognosis in cancer and infectious diseases. Host-directed therapy (HDT) via immune checkpoint blockade has revolutionized cancer treatment with therapeutic implications for chronic infections, thus laying the foundation for this review. Online literature searches were performed via PubMed, PubMed Central, and Google using the keywords "immune checkpoint inhibition"; "host-directed therapy"; "T cell exhaustion"; "cancer immunotherapy"; "anti-PD-1 therapy"; "anti-PD-L1 therapy"; "chronic infections"; "antigen-specific cells"; "tuberculosis"; "malaria"; "viral infections"; "human immunodeficiency virus"; "hepatitis B virus"; "hepatitis C virus"; "cytomegalovirus" and "Epstein-Barr virus". Search results were filtered based on relevance to the topics covered in this review. The use of monoclonal antibodies directed against the antigen-experienced T-cell marker programmed cell death 1 (PD-1) and its ligand PD-L1 in the context of chronic infectious diseases is reviewed. The potential pitfalls and precautions, based on clinical experience from treating patients with cancer with PD-1/PD-L1 pathway inhibitors, are also described. Anti-PD-1/PD-L1 therapy holds promise as adjunctive therapy for chronic infectious diseases such as tuberculosis and HIV, and must therefore be tested in randomized clinical trials. Copyright © 2017. Published by Elsevier Ltd.

  5. Parkinson's disease (PD is the most common neurodegenerative disease

    Directory of Open Access Journals (Sweden)

    P. A. Andoskin

    2015-01-01

    Full Text Available Metabolic impairment of alpha-synuclein protein is considered to be the central event in PDpathogenesis. Recent studies explored usage of alpha-synuclein in peripheral fluids as a biomarker of PD, however alpha-synuclein level in the CSF and plasma is considered to be affected by hemolysis. In order to avoid contamination of a lymphocyte fraction by erythrocytes, we have proposed an algorithm based on measurements of alpha-synuclein levels in the homogeneous CD45+ cell blood fraction. For this study we formed a group of PD patients (N=14 and a control group without the neurological disorders (N=17. We found an increase in the level of the total alpha-synuclein in CD45+ cells of PD patients compared to controls (p = 0,04, and revealed a direct correlation between the level of dopamine in plasma and level of total alpha-synuclein in CD45+ cells in the control group (r=0,71, p = 0,007.The level of alpha-synuclein in CD45+ cells could be suggested as possible PD biomarker.

  6. Restless Legs Syndrome (RLS) and Parkinson's disease (PD)-related disorders or different entities?

    Science.gov (United States)

    Möller, Jens Carsten; Unger, Marcus; Stiasny-Kolster, Karin; Oertel, Wolfgang Hermann

    2010-02-15

    The relationship between Restless Legs Syndrome (RLS) and Parkinson's disease (PD) is still controversial. Most genetic, pathological, and imaging data argue against a close association of these two disorders. Still, many studies reported an increased prevalence of RLS in PD patients. These studies are difficult to interpret because the current diagnostic criteria for RLS have not been validated in PD patients. Although many PD patients suffer from motor restlessness due to parkinsonism and may thus mimic RLS, the risk for (secondary) RLS in PD patients is probably slightly increased. This review provides an overview of the current pertinent literature and discusses the possible association between RLS and PD.

  7. Factors associated with preparedness of the US healthcare system to respond to a pediatric surge during an infectious disease pandemic: Is our nation prepared?

    Science.gov (United States)

    Anthony, Christy; Thomas, Tito Joe; Berg, Bridget M; Burke, Rita V; Upperman, Jeffrey S

    2017-01-01

    Recent incidents have demonstrated that the US health system is unprepared for infectious pandemics resulting in a pediatric surge. Development of efficient plans and a structured and coordinated regional response to pediatric pandemic surge remains an opportunity. To address this gap, we conducted a literature review to assess current efforts, propose a response plan structure, and recommend policy actions. A literature review, utilizing MEDLINE and PubMed, through March 2017 identified articles regarding infectious disease pandemics affecting the US pediatric population. After review of current literature, a proposed response plan structure for a pediatric pandemic surge was designed. Inclusion and exclusion criteria reduced an initial screening of 1,787 articles to 162 articles. Articles ranged in their discussion of pediatric pandemic surge. Review of the articles led to the proposal of organizing the results according to 4 S's; (1) Structure, (2) Staff, (3) Stuff (Resources), and (4) Space. The review has supported the concern that the US health system is unprepared for a pediatric surge induced by infectious disease pandemics. Common themes suggest that response plans should reflect the 4Ss and national guidelines must be translated into regional response systems that account for local nuances.

  8. Parkinson's Disease Case Ascertainment in the EPIC Cohort : The NeuroEPIC4PD Study

    NARCIS (Netherlands)

    Gallo, Valentina; Brayne, Carol; Forsgren, Lars; Barker, Roger A; Petersson, Jesper; Hansson, Oskar; Lindqvist, Daniel; Ruffmann, Claudio; Ishihara, Lianna; Luben, Robert; Arriola, Larraitz; Bergareche, Alberto; Gavrila, Diana; Erro, Maria Elena; Vanacore, Nicola; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Vermeulen, Roel; Seelen, Meinie; Sieri, Sabina; Masala, Giovanna; Ramat, Silvia; Kyrozis, Andreas; Thricopolou, Antonia; Panico, Salvatore; Mattiello, Amalia; Kaaks, Rudolf; Teucher, Birgit; Katzke, Verena; Kloss, Manja; Curry, Lisa; Calboli, Federico; Riboli, Elio; Vineis, Paolo; Middleton, Lefkos

    2015-01-01

    BACKGROUND/AIMS: Large epidemiological prospective studies represent an important opportunity for investigating risk factors for rare diseases such as Parkinson's disease (PD). Here we describe the procedures we used for ascertaining PD cases in the EPIC (European Prospective Investigation into

  9. DRUM-PD: The use of a drum circle to improve the symptoms and signs of Parkinson's disease (PD).

    Science.gov (United States)

    Pantelyat, Alexander; Syres, Candace; Reichwein, Suzanne; Willis, Allison

    2016-01-01

    Physical therapy can improve motor function in patients with PD. Music performance may be used to improve motor skills by rhythmic entrainment. Drumming has long been a part of traditional healing rituals worldwide, and is increasingly being utilized as a therapeutic strategy. This pilot controlled prospective cohort trial assessed feasibility and effects of twice-weekly group West African drum circle classes for 6 weeks on PD patients' quality of life, symptoms, motor findings, cognition, and mood. Ten patients with PD were recruited into the drum circle group. Ten patients with PD were matched pairwise to each of the drum circle participants, and enrolled in a no-intervention control group. Both groups completed the PD-specific Parkinson Disease Questionnaire (PDQ)-39 quality of life assessment and the Geriatric Depression Scale (GDS), and underwent motor and cognitive assessments by a rater blinded to group at baseline, 6 weeks, and 12 weeks. Drummers had significantly improved PDQ-39 scores from baseline to 6 weeks (-5.8, p=0.042), whereas the control group's scores were unchanged. Walking performance was significantly faster at baseline for controls; after 6 weeks of drumming this difference was no longer significant, and remained non-significant at 12 weeks. The drummers trended (p=0.069) toward improvement in walking from baseline to 12 weeks. Other outcomes did not significantly change from baseline to 6 or 12 weeks. Drum circle classes significantly and reversibly improved quality of life in patients with PD. This pilot trial's findings merit larger controlled investigations comparing drumming classes to established interventions in PD, such as physical therapy.

  10. DRUM-PD: The use of a drum circle to improve the symptoms and signs of Parkinson's disease (PD)

    Science.gov (United States)

    Pantelyat, Alexander; Syres, Candace; Reichwein, Suzanne; Willis, Allison

    2015-01-01

    Background Physical therapy can improve motor function in patients with PD. Music performance may be used to improve motor skills by rhythmic entrainment. Drumming has long been a part of traditional healing rituals worldwide, and is increasingly being utilized as a therapeutic strategy. Methods This pilot controlled prospective cohort trial assessed feasibility and effects of twice-weekly group West African drum circle classes for 6 weeks on PD patients’ quality of life, symptoms, motor findings, cognition, and mood. Ten patients with PD were recruited into the drum circle group. Ten patients with PD were matched pairwise to each of the drum circle participants, and enrolled in a no-intervention control group. Both groups completed the PD-specific Parkinson Disease Questionnaire (PDQ)-39 quality of life assessment and the Geriatric Depression Scale (GDS), and underwent motor and cognitive assessments by a rater blinded to group at baseline, 6 weeks, and 12 weeks. Results Drummers had significantly improved PDQ-39 scores from baseline to 6 weeks (−5.8, p=0.042), whereas the control group's scores were unchanged. Walking performance was significantly faster at baseline for controls; after 6 weeks of drumming this difference was no longer significant, and remained non-significant at 12 weeks. The drummers trended (p=0.069) toward improvement in walking from baseline to 12 weeks. Other outcomes did not significantly change from baseline to 6 or 12 weeks. Conclusions Drum circle classes significantly and reversibly improved quality of life in patients with PD. This pilot trial's findings merit larger controlled investigations comparing drumming classes to established interventions in PD, such as physical therapy. PMID:27340683

  11. PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease.

    Science.gov (United States)

    Noyce, Alastair J; R'Bibo, Lea; Peress, Luisa; Bestwick, Jonathan P; Adams-Carr, Kerala L; Mencacci, Niccolo E; Hawkes, Christopher H; Masters, Joseph M; Wood, Nicholas; Hardy, John; Giovannoni, Gavin; Lees, Andrew J; Schrag, Anette

    2017-02-01

    A number of early features can precede the diagnosis of Parkinson's disease (PD). To test an online, evidence-based algorithm to identify risk indicators of PD in the UK population. Participants aged 60 to 80 years without PD completed an online survey and keyboard-tapping task annually over 3 years, and underwent smell tests and genotyping for glucocerebrosidase (GBA) and leucine-rich repeat kinase 2 (LRRK2) mutations. Risk scores were calculated based on the results of a systematic review of risk factors and early features of PD, and individuals were grouped into higher (above 15th centile), medium, and lower risk groups (below 85th centile). Previously defined indicators of increased risk of PD ("intermediate markers"), including smell loss, rapid eye movement-sleep behavior disorder, and finger-tapping speed, and incident PD were used as outcomes. The correlation of risk scores with intermediate markers and movement of individuals between risk groups was assessed each year and prospectively. Exploratory Cox regression analyses with incident PD as the dependent variable were performed. A total of 1323 participants were recruited at baseline and >79% completed assessments each year. Annual risk scores were correlated with intermediate markers of PD each year and baseline scores were correlated with intermediate markers during follow-up (all P values < 0.001). Incident PD diagnoses during follow-up were significantly associated with baseline risk score (hazard ratio = 4.39, P = .045). GBA variants or G2019S LRRK2 mutations were found in 47 participants, and the predictive power for incident PD was improved by the addition of genetic variants to risk scores. The online PREDICT-PD algorithm is a unique and simple method to identify indicators of PD risk. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2016 International Parkinson and Movement Disorder

  12. Differential Effects of Tango Versus Dance for PD in Parkinson Disease

    Science.gov (United States)

    McNeely, Marie E.; Mai, Marina M.; Duncan, Ryan P.; Earhart, Gammon M.

    2015-01-01

    Over half of the general population does not achieve recommended daily levels of physical activity, and activity levels in people with Parkinson disease (PD) are lower than in healthy older adults. Dance can serve as an adjunct to traditional treatments to improve gait, balance, and quality of life in people with PD. This study directly compares a tango dance intervention and a dance intervention based on the Dance for PD model, which integrates multiple dance styles. Eleven people with PD participated in a community-based mixed styles dance intervention called Dance for Parkinson’s (D4PD). Participants in the D4PD group were matched to participants in an ongoing community-based exercise study who participated in tango dance. The groups received 12 weeks of intervention, attending 1-h group classes twice a week. Participants were evaluated off anti-PD medication before and after intervention. Measures of balance, repeated sit-to-stand performance and endurance (mini-balance evaluation systems test, four square step test, five times sit to stand, 6-min walk time) improved from pre to post similarly in both groups. Motor sign severity (movement disorders society unified Parkinson disease rating scale motor subsection) and functional mobility (timed up and go) improved in the tango group and worsened in the D4PD group. Gait velocity was not affected by either intervention. Direct comparisons of different interventions are ­critical for developing optimal exercise interventions designed to specifically target motor impairments in PD. Tango dance interventions may preferentially improve mobility and motor signs in people with PD, compared to D4PD. PMID:26733865

  13. Differential Effects of Tango Versus Dance for PD in Parkinson Disease.

    Science.gov (United States)

    McNeely, Marie E; Mai, Marina M; Duncan, Ryan P; Earhart, Gammon M

    2015-01-01

    Over half of the general population does not achieve recommended daily levels of physical activity, and activity levels in people with Parkinson disease (PD) are lower than in healthy older adults. Dance can serve as an adjunct to traditional treatments to improve gait, balance, and quality of life in people with PD. This study directly compares a tango dance intervention and a dance intervention based on the Dance for PD model, which integrates multiple dance styles. Eleven people with PD participated in a community-based mixed styles dance intervention called Dance for Parkinson's (D4PD). Participants in the D4PD group were matched to participants in an ongoing community-based exercise study who participated in tango dance. The groups received 12 weeks of intervention, attending 1-h group classes twice a week. Participants were evaluated off anti-PD medication before and after intervention. Measures of balance, repeated sit-to-stand performance and endurance (mini-balance evaluation systems test, four square step test, five times sit to stand, 6-min walk time) improved from pre to post similarly in both groups. Motor sign severity (movement disorders society unified Parkinson disease rating scale motor subsection) and functional mobility (timed up and go) improved in the tango group and worsened in the D4PD group. Gait velocity was not affected by either intervention. Direct comparisons of different interventions are -critical for developing optimal exercise interventions designed to specifically target motor impairments in PD. Tango dance interventions may preferentially improve mobility and motor signs in people with PD, compared to D4PD.

  14. [Relationship between G6PD deficiency and hand-foot-mouth disease induced by enterovirus 71].

    Science.gov (United States)

    Ou, Jun-Bin; Zhang, Cui-Mei; Fu, Si-Mao; Huang, Xiang; Huang, Lian-Hong

    2013-09-01

    To study the influence of glucose-6-phosphate dehydrogenase (G6PD) deficiency on hand-foot-mouth disease (HFMD) induced by enterovirus 71 (EV71) , and possible mechanisms. A total of 220 boys with HFMD induced by EV71 were classified into two groups based on disease severity: mild/moderate (n=145) and severe HFMD groups (n=75), and 132 healthy boys were selected as the control group. The activity of G6PD and levels of reduced glutathione (GSH) and malonaldehyde (MDA) in blood were measured using the automatic biochemical analyzer. The percentage of G6PD deficiency cases in the severe HFMD group was significantly higher than in the control group (PG6PD deficiency than in those with normal G6PD activity (PG6PD deficiency had significantly lower GSH levels and significantly higher MDA levels compared with those with normal G6PD activity (PG6PD deficiency is probably a predisposing factor for HFMD induced by EV71 and may aggravate the patient's condition. Its mechanism might be related to oxidative stress.

  15. Pressure surge attenuator

    Science.gov (United States)

    Christie, Alan M.; Snyder, Kurt I.

    1985-01-01

    A pressure surge attenuation system for pipes having a fluted region opposite crushable metal foam. As adapted for nuclear reactor vessels and heads, crushable metal foam is disposed to attenuate pressure surges.

  16. Differential effects of tango versus Dance for PD in Parkinson disease

    Directory of Open Access Journals (Sweden)

    Marie E McNeely

    2015-12-01

    Full Text Available Over half of the general population does not achieve recommended daily levels of physical activity, and activity levels in people with Parkinson disease (PD are lower than in healthy older adults. Dance can serve as an adjunct to traditional treatments to improve gait, balance, and quality of life in people with PD. This study directly compares a tango dance intervention and a dance intervention based on the Dance for PD model which integrates multiple dance styles. Eleven people with PD participated in a community-based mixed styles dance intervention called Dance for Parkinson’s (D4PD. Participants in the D4PD group were matched to participants in an ongoing community-based exercise study who participated in tango dance. The groups received 12 weeks of intervention, attending one-hour group classes twice a week. Participants were evaluated off anti-PD medication before and after intervention. Measures of balance, repeated sit-to-stand performance and endurance (Mini-BESTest, four square step test, five times sit to stand, six minute walk time improved from pre to post similarly in both groups. Motor sign severity (MDS-UPDRS-III and functional mobility (TUG improved in the tango group and worsened in the D4PD group. Gait velocity was not affected by either intervention. Direct comparisons of different interventions are critical for developing optimal exercise interventions designed to specifically target motor impairments in PD. Tango dance interventions may preferentially improve mobility and motor signs in people with PD, compared to D4PD.

  17. Cross cultural adaptations and psychometric domains of Brazilian version of PROFILE PD for Parkinson's disease.

    Science.gov (United States)

    Swarowsky, Alessandra; Fontana, Samanta Rattis Canterle Bez; Santos, Mariana Palla; Silva, Bruna Adriana Da; Spagnuolo, Gessyca; Ovando, Angélica Cristiane; Ilha, Jocemar

    2017-08-01

    The PROFILE PD scale was developed specifically to evaluate patients with Parkinson's disease (PD) within the context of the International Classification of Functioning, Disability and Health, directly applied to physical therapy practice. The study aimed to translate and cross-culturally adapt the PROFILE PD scale to Portuguese-Brazil, and to analyze its psychometric domains. Fifty participants with PD participated in the study. We assessed the clarity of the Brazilian version of the scale by physiotherapists, presence of floor and ceiling effects, interrater and test-retest reliabilities, in addition to discriminant, concurrent (UPDRS) and construct validity, internal consistence, minimal detectable change (MDC), and responsiveness. The scale was considered highly clear for physical therapists. The interrater ICC was 0.74 and Wk was 0.89 for the total score. For test-retest reliability, the total ICC score was 0.99. The analysis of concurrent validity showed the Spearman correlation between Brazilian version of PROFILE PD and UPDRS (ρ = 0.77; p PROFILE PD was able to discriminate the subject with PD in mild and moderate stages, and in mild and severe stages. A high internal consistency was found (α = 0.99). MDC was 2.41 points and there were no floor and ceiling effects. Also, the scale was responsive to physical therapy intervention, with improvement in 8 points after two months (effect size = 0.85). The Brazilian version of PROFILE PD is an instrument reliable, valid, and responsive to physical therapy intervention, that can be used to quantify impairments and limitations in patients with PD and can provide an overall summary of the impact of disease, useful for physiotherapy practice. Implications for Rehabilitation PROFILE PD is a reliable and valid instrument to be applied in Brazilian Parkinson disease patients. This scale is design specially to be used in physical therapy practice within the contexts surrounding the International Classification

  18. Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson's Disease (PD).

    Science.gov (United States)

    Tuite, Paul

    2017-06-16

    Magnetic resonance imaging (MRI) has the potential to serve as a biomarker for Parkinson's disease (PD). However, the type or types of biomarker it could provide remain to be determined. At this time there is not sufficient sensitivity or specificity for MRI to serve as an early diagnostic biomarker, i.e., it is unproven in its ability to determine if a single individual is normal, has mild PD, or has some other forms of degenerative parkinsonism. However there is accumulating evidence that MRI may be useful in staging and monitoring disease progression (staging biomarker), and also possibly as a means to monitor pathophysiological aspects of disease and associated response to treatments, i.e., theranostic marker. As there are increasing numbers of manuscripts that are dedicated to diffusion- and neuromelanin-based imaging methods, this review will focus on these topics cursorily and will delve into pharmacodynamic imaging as a means to get at theranostic aspects of PD.

  19. Production of verbs related to body movement in amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD).

    Science.gov (United States)

    Cousins, Katheryn A Q; Ash, Sharon; Grossman, Murray

    2018-03-01

    Theories of grounded cognition propose that action verb knowledge relies in part on motor processing regions, including premotor cortex. Accordingly, impaired action verb knowledge in patients with amyotrophic lateral sclerosis (ALS) and Parkinson's Disease (PD) is thought to be due to motor system degeneration. Upper motor neuron disease in ALS degrades the motor cortex and related pyramidal motor system, while disease in PD is centered in the basal ganglia and can spread to frontostriatal areas that are important to language functioning. These anatomical distinctions in disease may yield subtle differences in the action verb impairment between patient groups. Here we compare verbs where the body is the agent of the action to verbs where the body is the theme. To examine the role of motor functioning in body verb production, we split patient groups into patients with high motor impairment (HMI) and those with low motor impairment (LMI), using disease-specific measures of motor impairment. Regression analyses assessed how verb production in ALS and PD was related to motor system atrophy. We find a dissociation between agent- and theme-body verbs in ALS: ALS HMI were impaired for agent body verbs but not theme verbs, compared to ALS LMI. This dissociation was not present in PD patients, who instead show depressed production for all body verbs. Although patients with cognitive impairment were excluded from this study, cognitive performance significantly correlated with the production of theme verbs in ALS and cognitive/stative verbs in PD. Finally, regression analyses related the agent-theme dissociation in ALS to grey matter atrophy of premotor cortex. These findings support the view that motor dysfunction and disease in premotor cortex contributes to the agent body verb deficit in ALS, and begin to identify some distinct characteristics of impairment for verbs in ALS and PD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

    LENUS (Irish Health Repository)

    Guo, Yanxia

    2018-01-01

    Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralgia and inflammatory arthritis (IA) in some patients. Herein, using Nivolumab (anti-PD-1 antagonist)-responsive genes along with transcriptomics of synovial tissue from multiple stages of rheumatoid arthritis (RA) disease progression, we have interrogated the activity status of PD-1 pathway during RA development. We demonstrate that the expression of PD-1 was increased in early and established RA synovial tissue compared to normal and OA synovium, whereas that of its ligands, programmed death ligand-1 (PD-L1) and PD-L2, was increased at all the stages of RA disease progression, namely arthralgia, IA\\/undifferentiated arthritis, early RA and established RA. Further, we show that RA patients expressed PD-1 on a majority of synovial tissue infiltrating CD4+ and CD8+ T cells. Moreover, enrichment of Nivolumab gene signature was observed in IA and RA, indicating that the PD-1 pathway was downregulated during RA disease progression. Furthermore, serum soluble (s) PD-1 levels were increased in autoantibody positive early RA patients. Interestingly, most of the early RA synovium tissue sections showed negative PD-L1 staining by immunohistochemistry. Therefore, downregulation in PD-1 inhibitory signaling in RA could be attributed to increased serum sPD-1 and decreased synovial tissue PD-L1 levels. Taken together, these data suggest that agonistic PD1 antibody-based therapeutics may show efficacy in RA treatment and interception.

  1. Characterization of the Xylella fastidiosa PD1311 gene mutant and its suppression of Pierce's disease on grapevines.

    Science.gov (United States)

    Hao, Lingyun; Johnson, Kameka; Cursino, Luciana; Mowery, Patricia; Burr, Thomas J

    2017-06-01

    Xylella fastidiosa causes Pierce's disease (PD) on grapevines, leading to significant economic losses in grape and wine production. To further our understanding of X. fastidiosa virulence on grapevines, we examined the PD1311 gene, which encodes a putative acyl-coenzyme A (acyl-CoA) synthetase, and is highly conserved across Xylella species. It was determined that PD1311 is required for virulence, as the deletion mutant, ΔPD1311, was unable to cause disease on grapevines. The ΔPD1311 strain was impaired in behaviours known to be associated with PD development, including motility, aggregation and biofilm formation. ΔPD1311 also expressed enhanced sensitivity to H 2 O 2 and polymyxin B, and showed reduced survival in grapevine sap, when compared with wild-type X. fastidiosa Temecula 1 (TM1). Following inoculation, ΔPD1311 could not be detected in grape shoots, which may be related to its altered growth and sensitivity phenotypes. Inoculation with ΔPD1311 2 weeks prior to TM1 prevented the development of PD in a significant fraction of vines and eliminated detectable levels of TM1. In contrast, vines inoculated simultaneously with TM1 and ΔPD1311 developed disease at the same level as TM1 alone. In these vines, TM1 populations were distributed similarly to populations in TM1-only inoculated plants. These findings suggest that, through an indirect mechanism, pretreatment of vines with ΔPD1311 suppresses pathogen population and disease. © 2016 BSPP AND JOHN WILEY & SONS LTD.

  2. [Neonatal screening of hemoglobinopathies and G6PD deficiency in Catalonia (Spain). Molecular study of sickle cell disease associated with alpha thalassemia and G6PD deficiency].

    Science.gov (United States)

    Mañú Pereira, María Del Mar; Cabot, Anna; Martínez González, Ana; Sitjà Navarro, Eulalia; Cararach, Vicent; Sabrià, Josep; Boixaderas, Jordi; Teixidor, Roser; Bosch, Albert; López Vílchez, M Angeles; Martín Ibáñez, Itziar; Carrión, Teresa; Plaja, Pere; Sánchez, Mario; Vives Corrons, José Luis

    2007-06-30

    The prevalence of hemoglobinopathies and glucose-6-phosphate dehidrogenase (G6PD) deficiency in the Catalan neonatal population is increasing due to immigration. Coinheritance of more than a single RBC genetic defect is becoming more frequent and diagnostic pitfalls are also increasing. We intended to demonstrate the need to perform an early diagnosis of sickle cell disease (SCD) by means of neonatal screening, to establish the prevalence of SCD associated with alpha thalassemia and G6PD deficiency and to identify genotypes associated with sickle cell disease and G6PD deficiency. 4,020 blood samples from newborns were screened. For the screening of hemoglobinopathies the high performance liquid chromatography method was used and for G6PD deficiency the fluorescent spot test was employed. We studied the association between betaS gene and alpha thalassaemia del-3.7 Kb. SCD and G6PD deficiency genotypes were established. Prevalence of SCD in population at risk was 1/475 newborns. Prevalence of G6PD deficiency in population at risk was 1/43, and in autochthonous population was 1/527 newborns. In all the cases, sickle hemoglobin was confirmed by ARMS (amplification refractory mutation system). Association between betaS gene and alpha thalassaemia del-3.7 Kb was found in 32.2% of the samples, and an association between betaS gene and G6PD deficiency was observed in 7% of the samples. This study confirms the high prevalence of SCD and G6PD deficiency in population at risk as well as their genetic and clinical heterogeneity. The study of genotype/phenotype relationships allows a better knowledge of molecular mechanism and is useful to establish suitable criteria of diagnosis.

  3. PD_Manager: an mHealth platform for Parkinson's disease patient management.

    Science.gov (United States)

    Tsiouris, Kostas M; Gatsios, Dimitrios; Rigas, George; Miljkovic, Dragana; Koroušić Seljak, Barbara; Bohanec, Marko; Arredondo, Maria T; Antonini, Angelo; Konitsiotis, Spyros; Koutsouris, Dimitrios D; Fotiadis, Dimitrios I

    2017-06-01

    PD_Manager is a mobile health platform designed to cover most of the aspects regarding the management of Parkinson's disease (PD) in a holistic approach. Patients are unobtrusively monitored using commercial wrist and insole sensors paired with a smartphone, to automatically estimate the severity of most of the PD motor symptoms. Besides motor symptoms monitoring, the patient's mobile application also provides various non-motor self-evaluation tests for assessing cognition, mood and nutrition to motivate them in becoming more active in managing their disease. All data from the mobile application and the sensors is transferred to a cloud infrastructure to allow easy access for clinicians and further processing. Clinicians can access this information using a separate mobile application that is specifically designed for their respective needs to provide faster and more accurate assessment of PD symptoms that facilitate patient evaluation. Machine learning techniques are used to estimate symptoms and disease progression trends to further enhance the provided information. The platform is also complemented with a decision support system (DSS) that notifies clinicians for the detection of new symptoms or the worsening of existing ones. As patient's symptoms are progressing, the DSS can also provide specific suggestions regarding appropriate medication changes.

  4. Mapping infectious disease hospital surge threats to lessons learnt in Singapore: a systems analysis and development of a framework to inform how to DECIDE on planning and response strategies.

    Science.gov (United States)

    Singh, Shweta R; Coker, Richard; Vrijhoef, Hubertus J-M; Leo, Yee Sin; Chow, Angela; Lim, Poh Lian; Tan, Qinghui; Chen, Mark I-Cheng; Hildon, Zoe Jane-Lara

    2017-09-04

    Hospital usage and service demand during an Infectious Disease (ID) outbreak can tax the health system in different ways. Herein we conceptualize hospital surge elements, and lessons learnt from such events, to help build appropriately matched responses to future ID surge threats. We used the Interpretive Descriptive qualitative approach. Interviews (n = 35) were conducted with governance and public health specialists; hospital based staff; and General Practitioners. Key policy literature in tandem with the interview data were used to iteratively generate a Hospital ID Surge framework. We anchored our narrative account within this framework, which is used to structure our analysis. A spectrum of surge threats from combinations of capacity (for crowding) and capability (for treatment complexity) demands were identified. Starting with the Pyramid scenario, or an influx of high screening rates flooding Emergency Departments, alongside fewer and manageable admissions; the Reverse-Pyramid occurs when few cases are screened and admitted but those that are, are complex; during a 'Black' scenario, the system is overburdened by both crowding and complexity. The Singapore hospital system is highly adapted to crowding, functioning remarkably well at constant near-full capacity in Peacetime and resilient to Endemic surges. We catalogue 26 strategies from lessons learnt relating to staffing, space, supplies and systems, crystalizing institutional memory. The DECIDE model advocates linking these strategies to types of surge threats and offers a step-by-step guide for coordinating outbreak planning and response. Lack of a shared definition and decision making of surge threats had rendered the procedures somewhat duplicative. This burden was paradoxically exacerbated by a health system that highly prizes planning and forward thinking, but worked largely in silo until an ID crisis hit. Many such lessons can be put into play to further strengthen our current hospital governance

  5. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease.

    Science.gov (United States)

    Berg, Daniela; Postuma, Ronald B; Bloem, Bastiaan; Chan, Piu; Dubois, Bruno; Gasser, Thomas; Goetz, Christopher G; Halliday, Glenda M; Hardy, John; Lang, Anthony E; Litvan, Irene; Marek, Kenneth; Obeso, José; Oertel, Wolfgang; Olanow, C Warren; Poewe, Werner; Stern, Matthew; Deuschl, Günther

    2014-04-01

    With advances in knowledge disease, boundaries may change. Occasionally, these changes are of such a magnitude that they require redefinition of the disease. In recognition of the profound changes in our understanding of Parkinson's disease (PD), the International Parkinson and Movement Disorders Society (MDS) commissioned a task force to consider a redefinition of PD. This review is a discussion article, intended as the introductory statement of the task force. Several critical issues were identified that challenge current PD definitions. First, new findings challenge the central role of the classical pathologic criteria as the arbiter of diagnosis, notably genetic cases without synuclein deposition, the high prevalence of incidental Lewy body (LB) deposition, and the nonmotor prodrome of PD. It remains unclear, however, whether these challenges merit a change in the pathologic gold standard, especially considering the limitations of alternate gold standards. Second, the increasing recognition of dementia in PD challenges the distinction between diffuse LB disease and PD. Consideration might be given to removing dementia as an exclusion criterion for PD diagnosis. Third, there is increasing recognition of disease heterogeneity, suggesting that PD subtypes should be formally identified; however, current subtype classifications may not be sufficiently robust to warrant formal delineation. Fourth, the recognition of a nonmotor prodrome of PD requires that new diagnostic criteria for early-stage and prodromal PD should be created; here, essential features of these criteria are proposed. Finally, there is a need to create new MDS diagnostic criteria that take these changes in disease definition into consideration. © 2014 International Parkinson and Movement Disorder Society.

  6. Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial.

    Science.gov (United States)

    Postuma, Ronald B; Anang, Julius; Pelletier, Amelie; Joseph, Lawrence; Moscovich, Mariana; Grimes, David; Furtado, Sarah; Munhoz, Renato P; Appel-Cresswell, Silke; Moro, Adriana; Borys, Andrew; Hobson, Douglas; Lang, Anthony E

    2017-10-24

    To assess effects of caffeine on Parkinson disease (PD). In this multicenter parallel-group controlled trial, patients with PD with 1-8 years disease duration, Hoehn & Yahr stages I-III, on stable symptomatic therapy were randomized to caffeine 200 mg BID vs matching placebo capsules for 6-18 months. The primary research question was whether objective motor scores would differ at 6 months (Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale [MDS-UPDRS]-III, Class I evidence). Secondary outcomes included safety and tolerability, motor symptoms (MDS-UPDRS-II), motor fluctuations, sleep, nonmotor symptoms (MDS-UPDRS-I), cognition (Montreal Cognitive Assessment), and quality of life. Sixty patients received caffeine and 61 placebo. Caffeine was well-tolerated with similar prevalence of side effects as placebo. There was no improvement in motor parkinsonism (the primary outcome) with caffeine treatment compared to placebo (difference between groups -0.48 [95% confidence interval -3.21 to 2.25] points on MDS-UPDRS-III). Similarly, on secondary outcomes, there was no change in motor signs or motor symptoms (MDS-UPDRS-II) at any time point, and no difference on quality of life. There was a slight improvement in somnolence over the first 6 months, which attenuated over time. There was a slight increase in dyskinesia with caffeine (MDS-UPDRS-4.1+4.2 = 0.25 points higher), and caffeine was associated with worse cognitive testing scores (average Montreal Cognitive Assessment = 0.66 [0.01, 1.32] worse than placebo). Caffeine did not provide clinically important improvement of motor manifestations of PD (Class I evidence). Epidemiologic links between caffeine and lower PD risk do not appear to be explained by symptomatic effects. NCT01738178. This study provides Class I evidence that for patients with PD, caffeine does not significantly improve motor manifestations. © 2017 American Academy of Neurology.

  7. The Epidemiology and Surveillance Workforce Among Local Health Departments in California: Mutual Aid and Surge Capacity for Routine and Emergency Infectious Disease Situations

    Science.gov (United States)

    Crawley, Adam W.; Hunter, Jennifer C.; Balido, Jeannie; Aragon, Tomas J.

    2014-01-01

    Objective Public health surveillance and epidemiologic investigations are critical public health functions for identifying threats to the health of a community. We conducted a survey of local health departments (LHDs) in California to describe the workforce that supports public health surveillance and epidemiologic functions during routine and emergency infectious disease situations. Methods The target population consisted of the 61 LHDs in California. The online survey instrument was designed to collect information about the workforce involved in key epidemiologic functions. We also examined how the public health workforce increases its epidemiologic capacity during infectious disease emergencies. Results Of 61 LHDs in California, 31 (51%) completed the survey. A wide range of job classifications contribute to epidemiologic functions routinely, and LHDs rely on both internal and external sources of epidemiologic surge capacity during infectious disease emergencies. This study found that while 17 (55%) LHDs reported having a mutual aid agreement with at least one other organization for emergency response, only nine (29%) LHDs have a mutual aid agreement specifically for epidemiology and surveillance functions. Conclusions LHDs rely on a diverse workforce to conduct epidemiology and public health surveillance functions, emphasizing the need to identify and describe the types of staff positions that could benefit from public health surveillance and epidemiology training. While some organizations collaborate with external partners to support these functions during an emergency, many LHDs do not rely on mutual aid agreements for epidemiology and surveillance activities. PMID:25355982

  8. Potential of Diffusion Tensor Imaging and Relaxometry for the Detection of Specific Pathological Alterations in Parkinson's Disease (PD.

    Directory of Open Access Journals (Sweden)

    Regina Esterhammer

    Full Text Available The purpose of the present study was to evaluate the potential of multimodal MR imaging including mean diffusivity (MD, fractional anisotropy (FA, relaxation rates R2 and R2* to detect disease specific alterations in Parkinson's Disease (PD. We enrolled 82 PD patients (PD-all with varying disease durations (≤5 years: PD≤5, n = 43; >5 years: PD>5, n = 39 and 38 matched healthy controls (HC, receiving diffusion tensor imaging as well as R2 and R2* relaxometry calculated from multi-echo T2*-weighted and dual-echo TSE imaging, respectively. ROIs were drawn to delineate caudate nucleus (CN, putamen (PU, globus pallidus (GP and substantia nigra (SN on the co-registered maps. The SN was divided in 3 descending levels (SL 1-3. The most significant parameters were used for a flexible discrimination analysis (FDA in a training collective consisting of 25 randomized subjects from each group in order to predict the classification of remaining subjects. PD-all showed significant increases in MD, R2 and R2* within SN and its subregions as well as in MD and R2* within different basal ganglia regions. Compared to the HC group, the PD≤5 and the PD>5 group showed significant MD increases within the SN and its lower two subregions, while the PD≤5 group exhibited significant increases in R2 and R2* within SN and its subregions, and tended to elevation within the basal ganglia. The PD>5 group had significantly increased MD in PU and GP, whereas the PD≤5 group presented normal MD within the basal ganglia. FDA achieved right classification in 84% of study participants. Micro-structural damage affects primarily the SN of PD patients and in later disease stages the basal ganglia. Iron contents of PU, GP and SN are increased at early disease stages of PD.

  9. Kawasaki disease with G6PD deficiency--report of one case and literature review.

    Science.gov (United States)

    Chen, Chia-Hao; Lin, Li-Yan; Yang, Kuender D; Hsieh, Kai-Sheng; Kuo, Ho-Chang

    2014-06-01

    Kawasaki disease (KD) is a systemic vasculitis primarily affecting children who are younger than 5 years. The most serious complications are coronary artery aneurysms and sequelae of vasculitis with the subsequent development of coronary artery aneurysm. According to the literature, intravenous immunoglobulin (IVIG) plus high-dose aspirin (acetylsalicylic acid) were standard treatment for KD, whereas low-dose aspirin (3-5 mg/kg/day) was used for thrombocytosis in KD via antiplatelet effect. However, aspirin has been reported to have hemolytic potential in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a child with G6PD-deficiency who has KD, and review the literature. Copyright © 2012. Published by Elsevier B.V.

  10. Fatigue and Muscle Strength Involving Walking Speed in Parkinson's Disease: Insights for Developing Rehabilitation Strategy for PD.

    Science.gov (United States)

    Huang, Ying-Zu; Chang, Fang-Yu; Liu, Wei-Chia; Chuang, Yu-Fen; Chuang, Li-Ling; Chang, Ya-Ju

    2017-01-01

    Background . Problems with gait in Parkinson's disease (PD) are a challenge in neurorehabilitation, partly because the mechanisms causing the walking disability are unclear. Weakness and fatigue, which may significantly influence gait, are commonly reported by patients with PD. Hence, the aim of this study was to investigate the association between weakness and fatigue and walking ability in patients with PD. Methods . We recruited 25 patients with idiopathic PD and 25 age-matched healthy adults. The maximum voluntary contraction (MVC), twitch force, and voluntary activation levels were measured before and after a knee fatigue exercise. General fatigue, central fatigue, and peripheral fatigue were quantified by exercise-induced changes in MVC, twitch force, and activation level. In addition, subjective fatigue was measured using the Multidimensional Fatigue Inventory (MFI) and Fatigue Severity Scale (FSS). Results . The patients with PD had lower activation levels, more central fatigue, and more subjective fatigue than the healthy controls. There were no significant differences in twitch force or peripheral fatigue index between the two groups. The reduction in walking speed was related to the loss of peripheral strength and PD itself. Conclusion . Fatigue and weakness of central origin were related to PD, while peripheral strength was important for walking ability. The results suggest that rehabilitation programs for PD should focus on improving both central and peripheral components of force.

  11. A Computerized Cognitive behavioral therapy Randomized, Controlled, pilot trial for insomnia in Parkinson Disease (ACCORD-PD)

    OpenAIRE

    Patel, Shnehal; Ojo, Oluwadamilola; Genc, Gencer; Oravivattanakul, Srivadee; Huo, Yang; Rasameesoraj, Tanaporn; Wang, Lu; Bena, James; Drerup, Michelle; Foldvary-Schaefer, Nancy; Ahmed, Anwar; Fernandez, Hubert H.

    2017-01-01

    Background Parkinson disease (PD) is associated with a high prevalence of insomnia, affecting up to 88% of patients. Pharmacotherapy studies in the literature addressing insomnia in PD reveal disappointing and inconsistent results. Cognitive behavioral therapy (CBT) is a novel treatment option with durable effects shown in primary insomnia. However, the lack of accessibility and expense can be limiting. For these reasons, computerized CBT for insomnia (CCBT-I) has been developed. The CCBT-I p...

  12. Quality of raw and smoked fillets from clinically healthy Atlantic salmon, Salmo salar L., following an outbreak of pancreas disease (PD)

    DEFF Research Database (Denmark)

    Taksdal, T.; Wiik‐Nielsen, J.; Birkeland, S.

    2012-01-01

    Pancreas disease (PD) is a viral disease of farmed salmonid fish, which causes huge economic losses. Pathological changes in skeletal muscle, pancreas and heart are hallmarks of PD. Stakeholders in the fish‐smoking industry have claimed that fillets from PD‐affected Atlantic salmon, Salmo salar L...... may indicate susceptibility to stress‐related heart failure....

  13. Effect of azilsartan versus candesartan on morning blood pressure surges in Japanese patients with essential hypertension.

    Science.gov (United States)

    Rakugi, Hiromi; Kario, Kazuomi; Enya, Kazuaki; Sugiura, Kenkichi; Ikeda, Yoshinori

    2014-06-01

    Morning blood pressure (BP) surge is reported as a risk factor for cardiovascular events and end-organ damage independent of the 24-h BP level. Controlling morning BP surge is therefore important to help prevent onset of cardiovascular disease. We compared the efficacy of azilsartan and candesartan in controlling morning systolic BP (SBP) surges by analyzing relevant ambulatory BP monitoring data in patients with/without baseline BP surges. As part of a 16-week randomized, double-blind study of azilsartan (20-40 mg once daily) and candesartan (8-12 mg once daily) in Japanese patients with essential hypertension, an exploratory analysis was carried out using ambulatory BP monitoring at baseline and week 14. The effects of study drugs on morning BP surges, including sleep trough surge (early morning SBP minus the lowest night-time SBP) and prewaking surge (early morning SBP minus SBP before awakening), were evaluated. Patients with sleep trough surge of at least 35 mmHg were defined by the presence of a morning BP surge (the 'surge group'). Sleep trough surge and prewaking surge data were available at both baseline and week 14 in 548 patients, 147 of whom (azilsartan 76; candesartan 71) had a baseline morning BP surge. In surge group patients, azilsartan significantly reduced both the sleep trough surge and the prewaking surge at week 14 compared with candesartan (least squares means of the between-group differences -5.8 mmHg, P=0.0395; and -5.7 mmHg, P=0.0228, respectively). Once-daily azilsartan improved sleep trough surge and prewaking surge to a greater extent than candesartan in Japanese patients with grade I-II essential hypertension.

  14. Two Year Exercise Program Improves Physical Function in Parkinson’s Disease: the PRET-PD Study

    Science.gov (United States)

    Prodoehl, Janey; Rafferty, Miriam; David, Fabian J.; Poon, Cynthia; Vaillancourt, David E.; Comella, Cynthia L.; Leurgans, Sue; Kohrt, Wendy M.; Corcos, Daniel M.; Robichaud, Julie A.

    2014-01-01

    Background The progressive resistance exercise (PRE) in Parkinson’s disease trial (PRET-PD) showed that PRE improved the motor signs of PD compared to a modified Fitness Counts (mFC) program. It is unclear how long-term exercise affects physical function in these individuals. Objective To examine the effects of long-term PRE and mFC on physical function outcome measures in individuals with PD. Methods A preplanned secondary analysis was conducted using data from the 38 patients with idiopathic PD who completed the PRET-PD trial. Participants were randomized into PRE or mFC groups and exercised 2 days/week up to 24 months. Blinded assessors obtained functional outcomes on and off medication at baseline, 6 and 24 months with the Modified Physical Performance Test (mPPT), five times sit to stand test (STS), Functional Reach Test (FRT), Timed Up and Go (TUG), Berg Balance Scale (BBS), 6 minute walk test (6MWT), and 50ft walking speed (walk speed). Results The groups did not differ on any physical function measure at 6 or 24 months (p’s > 0.1). Across time, all physical function measures improved from baseline to 24 months when tested on medication (p’s < .0001), except for 6MWT(p = .068). Off medication results were similar except that the 6MWT was now significant. Conclusions 24 months of supervised and structured exercise (either PRE or mFC) is effective at improving functional performance outcomes in individuals with moderate PD. Clinicians should strive to include structured and supervised exercise in the long-term plan of care for individuals with PD. PMID:24961994

  15. Unplanned Start on Peritoneal Dialysis Right after PD Catheter Implantation for Older People with End-Stage Renal Disease.

    Science.gov (United States)

    Povlsen, Johan V; Sørensen, Anette Bagger; Ivarsen, Per

    2015-11-01

    Unplanned start on dialysis remains a major problem for the dialysis community worldwide. Late-referred patients with end-stage renal disease (ESRD) and urgent need for dialysis are overrepresented among older people. These patients are particularly likely to be started on in-center hemodialysis (HD), with a temporary vascular access known to be associated with excess mortality and increased risks of potentially lethal complications such as bacteremia and central venous thrombosis or stenosis.The present paper describes in detail our program for unplanned start on automated peritoneal dialysis (APD) right after PD catheter implantation and summarizes our experiences with the program so far. Compared with planned start on PD after at least 2 weeks of break-in between PD catheter implantation and initiation of dialysis, unplanned start may be associated with a slight increased risk of mechanical complications but apparently no detrimental effect on mortality, peritonitis-free survival, or PD technique survival.In our opinion and experience, the risk of serious complications associated with the implantation and immediate use of a PD catheter is less than the risk of complications associated with unplanned start on HD with a temporary central venous catheter (CVC). Unplanned start on APD is a gentle, safe, and feasible alternative to unplanned start on HD with a temporary CVC that is also valid for the late-referred older patient with ESRD and urgent need for dialysis. Copyright © 2015 International Society for Peritoneal Dialysis.

  16. Effects of 2 Years of Exercise on Gait Impairment in People With Parkinson Disease: The PRET-PD Randomized Trial.

    Science.gov (United States)

    Rafferty, Miriam R; Prodoehl, Janey; Robichaud, Julie A; David, Fabian J; Poon, Cynthia; Goelz, Lisa C; Vaillancourt, David E; Kohrt, Wendy M; Comella, Cynthia L; Corcos, Daniel M

    2017-01-01

    This study presents a secondary analysis from the Progressive Resistance Exercise Training in Parkinson Disease (PRET-PD) trial investigating the effects of progressive resistance exercise (PRE) and a Parkinson disease (PD)-specific multimodal exercise program, modified Fitness Counts (mFC), on spatial, temporal, and stability-related gait impairments in people with PD. Forty-eight people with PD were randomized to participate in PRE or mFC 2 times a week for 24 months; 38 completed the study. Gait velocity, stride length, cadence, and double-support time were measured under 4 walking conditions (off-/on-medication, comfortable/fast speed). Ankle strength was also measured off- and on-medication. Twenty-four healthy controls provided comparison data at one time point. At 24 months, there were no significant differences between exercise groups. Both groups improved fast gait velocity off-medication, cadence in all conditions, and plantarflexion strength off-/on-medication. Both groups with PD had more gait measures that approximated the healthy controls at 24 months than at baseline. Plantarflexion strength was significantly associated with gait velocity and stride length in people with PD at baseline and 24 months, but changes in strength were not associated with changes in gait. Twenty-four months of PRE and mFC were associated with improved off-medication fast gait velocity and improved cadence in all conditions, which is important because temporal gait measures can be resistant to medications. Spatial and stability-related measures were resistant to long-term improvements, but did not decline over 24 months. Strength gains did not appear to transfer to gait.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A161).

  17. Electrodynamics properties of auroral surges

    International Nuclear Information System (INIS)

    Robinson, R.M.; Vondrak, R.R.

    1990-01-01

    The incoherent scatter radar technique provides an excellent means to study the ionization and electric fields associated with auroral precipitation events. One of the most intense and dynamic auroral events is the so-called surge or breakup aurora that accompanies auroral substorms. For their purposes they define a surge as a transient intensification of auroral precipitation that occurs simultaneously with a pronounced negative bay in the ground magnetometer data. They present data obtained during five such events in 1980 and 1981. Prior to the surge, auroral forms move equatorward, develop ray structure, and intensify. The surge is identified by an apparent poleward motion of the aurora producing aurorally associated ionization that extends over several hundred kilometers in latitude. The presurge auroral forms are embedded in a region of northward electric field. The auroral forms that comprise the surge span a region within which the meridional electric field is small and at times southward. A westward electric field is often but not always present within the surge. The behavior of the westward electric field is significantly different from the north-south field, in that sharp spatial gradients are absent even in very disturbed conditions. Although the westward Hall currents are mostly responsible for the negative bays that accompany the surge, at times the westward Pedersen current sustained by the westward electric field can be important. Sudden variations in the H component of the ground magnetogram can be caused by motions of the aurora or by temporal variations in the fields or conductivities. They present a model that simulates the observed changes in electric field and precipitation that accompany surges. The perturbation in the electric field produced by the surge is simulated by adding negative potential in regions of intense precipitation

  18. Myeloid-Derived Suppressor Cells Associated With Disease Progression in Primary HIV Infection: PD-L1 Blockade Attenuates Inhibition.

    Science.gov (United States)

    Zhang, Zi-Ning; Yi, Nan; Zhang, Tong-Wei; Zhang, Le-Le; Wu, Xian; Liu, Mei; Fu, Ya-Jing; He, Si-Jia; Jiang, Yong-Jun; Ding, Hai-Bo; Chu, Zhen-Xing; Shang, Hong

    2017-10-01

    Events occurring during the initial phase of human immunodeficiency virus (HIV) infection are intriguing because of their dramatic impact on the subsequent course of the disease. In particular, the relationship between myeloid-derived suppressor cells (MDSCs) and HIV pathogenesis in primary infection remains unknown and the mechanism of MDSCs in HIV infection are incompletely defined. The frequency of MDSC expression in patients with primary HIV infection (PHI) and chronic HIV infection was measured, and the association with disease progression was studied. Programmed death-ligand 1 (PD-L1) and galectin-9 (Gal-9) expression on MDSCs was measured and in vitro blocking experiments were performed to study the role of PD-L1 in MDSCs' inhibition. We found increased levels of HLA-DRCD14CD33CD11b granulocytic(G)-MDSCs in PHI individuals compared with normal controls, which correlated with viral loads and was negatively related to CD4 T-cell levels. When cocultured with purified G-MDSCs, both proliferation and interferon-γ secretion by T cell receptor (TCR)-stimulated CD8 T cells from HIV-infected patients were significantly inhibited. We also demonstrated that PD-L1, but not Gal-9, expression on HLA-DRCD14CD33CD11b cells increased during HIV infection. The suppressive activity of G-MDSCs from HIV-infected patients was attenuated by PD-L1 blockade. We found a significant increase in G-MDSCs in PHI patients that was related to disease progression and PD-L1 was used by MDSCs to inhibit CD8 T cells in HIV infection. Our data improve the understanding of HIV pathogenesis in PHI.

  19. The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study

    Directory of Open Access Journals (Sweden)

    Corbett Alastair

    2008-11-01

    Full Text Available Abstract Background We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2-related Parkinson's disease (PD in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser (G2019S, is associated with approximately 5 to 6% of familial PD cases and 1 to 2% of idiopathic cases, making it the most common known genetic cause of PD. Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD. Methods A sample, including 903 affected and 58 unaffected members from 509 families ascertained for having two or more PD-affected members, 126 randomly ascertained PD patients and 197 controls, was screened for five different LRRK2 mutations. Penetrance was estimated in families of LRRK2 carriers with consideration of the inherent bias towards increased penetrance in a familial sample. Results Thirty-one out of 509 families with multiple cases of PD (6.1% were found to have 58 LRRK2 mutation carriers (6.4%. Twenty-nine of the 31 families had G2019S mutations while two had R1441C mutations. No mutations were identified among controls or unaffected relatives of PD cases. Nine PD-affected relatives of G2019S carriers did not carry the LRRK2 mutation themselves. At the maximum observed age range of 90 to 94 years, the unbiased estimated penetrance was 67% for G2019S families, compared with a baseline PD risk of 17% seen in the non-LRRK2-related PD families. Conclusion Lifetime penetrance of LRRK2 estimated in the unascertained relatives of multiplex PD families is greater than that reported in studies of sporadically ascertained LRRK2 cases, suggesting that inherited susceptibility factors may modify the penetrance of LRRK2 mutations. In addition, the presence of nine PD phenocopies in the LRRK2 families suggests that these susceptibility

  20. PROFILE PD: profile of function and impairment level experience with Parkinson disease--clinimetric properties of a rating scale for physical therapist practice.

    Science.gov (United States)

    Schenkman, Margaret; McFann, Kimberly; Barón, Anna E

    2010-12-01

    Individuals with Parkinson disease (PD) experience a range of deficits of body systems and activities. A clinical test is needed that is reliable, valid, applicable to physical therapist practice, and appropriate for use in early and mid-stages of the disease. PROFILE PD is one such scale, consisting of 24 items that would typically be assessed during the physical therapist's examination and evaluation of individuals with PD. The purpose of this article is to report on clinimetric properties of the PROFILE PD and to make the test available for use. Interrater reliability was determined using the intraclass correlation coefficient. Construct validity was determined by comparing scores on the PROFILE PD with the gold standard (Unified Parkinson's Disease Rating Scale [UPDRS]) as well as scales of physical activity and participation. Construct validity and structure of the PROFILE PD were further examined using exploratory factor analysis using principal component analysis with Promax rotation that allows a correlated factor structure. Interrater reliability of the PROFILE PD was high (ICC = 0.97). Construct validity was demonstrated with the UPDRS (r = 0.86, P < 0.0001), Schwab & England Activities of Daily Living Scale (S&E) (r = -0.83, P < 0.0001), and Continuous Scale Physical Functional Performance test (r = -0.62, P < 0.0001). Principal component analysis demonstrated that the test comprises a single scale. The PROFILE PD is a reliable and valid scale that can be used to quantify alterations in body systems and activity of individuals in early and mid-stages of PD. Use of the scale can provide an overall summary of the impact of PD on body systems and activities.

  1. Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease.

    Science.gov (United States)

    Chen, Xiaoying; Farrokhi, Vahid; Singh, Pratap; Ocana, Mireia Fernandez; Patel, Jenil; Lin, Lih-Ling; Neubert, Hendrik; Brodfuehrer, Joanne

    2018-01-01

    Discovery of the upregulation of fibroblast growth factor-inducible-14 (Fn14) receptor following tissue injury has prompted investigation into biotherapeutic targeting of the Fn14 receptor for the treatment of conditions such as chronic kidney diseases. In the development of monoclonal antibody (mAb) therapeutics, there is an increasing trend to use biomeasures combined with mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modeling to enable decision making in early discovery. With the aim of guiding preclinical efforts on designing an antibody with optimized properties, we developed a mechanistic site-of-action (SoA) PK/PD model for human application. This model incorporates experimental biomeasures, including concentration of soluble Fn14 (sFn14) in human plasma and membrane Fn14 (mFn14) in human kidney tissue, and turnover rate of human sFn14. Pulse-chase studies using stable isotope-labeled amino acids and mass spectrometry indicated the sFn14 half-life to be approximately 5 hours in healthy volunteers. The biomeasures (concentration, turnover) of sFn14 in plasma reveals a significant hurdle in designing an antibody against Fn14 with desired characteristics. The projected dose (>1 mg/kg/wk for 90% target coverage) derived from the human PK/PD model revealed potential high and frequent dosing requirements under certain conditions. The PK/PD model suggested a unique bell-shaped relationship between target coverage and antibody affinity for anti-Fn14 mAb, which could be applied to direct the antibody engineering towards an optimized affinity. This investigation highlighted potential applications, including assessment of PK/PD risks during early target validation, human dose prediction and drug candidate optimization.

  2. Sleep disturbances in drug naïve Parkinson′s disease (PD patients and effect of levodopa on sleep

    Directory of Open Access Journals (Sweden)

    Teresa Ferreira

    2014-01-01

    Full Text Available Context: Parkinson′s disease (PD is associated with sleep disturbances, attributed to the neurodegenerative process and therapeutic drugs. Studies have found levodopa to increase wakefulness in some patients while increasing sleepiness in others. Aims: To confirm sleep disturbances in drug naïve PD patients and understand the impact of levodopa on their sleep. Materials and Methods: Twenty-three drug naοve PD patients and 31 age-gender matched controls were compared using the Parkinson′s Disease Sleep Scale (PDSS and Epworth Sleepiness Scale (ESS. A polysomnogram objectively compared sleep quality. Of the 23 patients, the 12 initiated on levodopa were reassessed subjectively and through polysomnography after 2 months of therapy. Statistical Analysis: Data was expressed as mean ± standard deviation, median, and range. Continuous variables were analyzed by Student′s T test for normally distributed data and Mann-Whitney U test for skewed data. Discrete variables were compared by Chi Square tests (Pearson Chi square Test or Fisher′s Exact Test. Wilcoxon signed ranks test was applied in the analysis of paired data pre- and post-levodopa. A P value < 0.05 was considered as statistically significant. Statistical analysis of the data was done using the Statistical Package for the Social Sciences (SPSS version 12. Results: Drug naïve PD patients had lower PDSS scores than controls. The sleep architecture changes observed on polysomnogram were reduced NREM Stage III and REM sleep and increased sleep latency and wake after sleep onset time. Following levodopa, improved sleep efficiency with reduced sleep latency and wake after sleep onset time was noted, coupled with improved PDSS scores. However, NREM Stage III and REM sleep duration did not increase. Discussion: PD patients take longer to fall asleep and have difficulty in sleep maintenance. Sleep maintenance is affected by nocturia, REM behavioral disorder, nocturnal cramps, akinesia, and

  3. Red cell glucose 6-phosphate dehydrogenase deficiency in the northern region of Turkey: is G6PD deficiency exclusively a male disease?

    Science.gov (United States)

    Albayrak, Canan; Albayrak, Davut

    2015-03-01

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive genetic defect that can cause hemolytic crisis. However, this disease affects both males and females. In Turkey, the frequency of this enzyme deficiency was reported to vary, from 0.25 to 18%, by the geographical area. Its prevalence in the northern Black Sea region of Turkey is unknown. The aims of this study were to assess the prevalence of G6PD deficiency in the northern region Turkey in children and adults with hyperbilirubinemia and hemolytic anemia. This report included a total of 976 G6PD enzyme results that were analyzed between May 2005 and January 2014. G6PD deficiency was detected in 5.0% of all patients. G6PD deficiency was significantly less frequent in females (1.9%, 6/323) than in males (6.6%, 43/653). G6PD deficiency was detected in 3.7% of infants with hyperbilirubinemia, 9.2% of children, and 4.5% of adults with hemolytic anemia. In both the newborn group and the group of children, G6PD deficiency was significantly more frequent in males. In the combined group of children (groups I and II), the proportion of males was 74% and 67% in all groups (P = .0008). In conclusion, in northern region of Turkey, G6PD deficiency is an important cause of neonatal hyperbilirubinemia and hemolytic crisis in children and adults. This study suggests that most pediatricians thought that G6PD deficiency is exclusively a male disease. For this reason, some female patients may have been undiagnosed.

  4. Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis

    DEFF Research Database (Denmark)

    Greisen, S. R.; Rasmussen, T. K.; Stengaard-Pedersen, K.

    2014-01-01

    to be implicated in disease activity in chronic rheumatoid arthritis (RA). METHOD: We measured sPD-1 at baseline and 9 months after treatment initiation in plasma from early RA patients (n = 34). We tested for correlations with the Disease Activity Score using 28 joint counts (DAS28), the Health Assessment...

  5. Programmed Death Ligand 1 (PD-L1 Tumor Expression Is Associated with a Better Prognosis and Diabetic Disease in Triple Negative Breast Cancer Patients

    Directory of Open Access Journals (Sweden)

    Gerardo Botti

    2017-02-01

    Full Text Available Triple Negative Breast Cancers (TNBC subtype is an aggressive disease with poor clinical outcome. The only treatment available is surgery followed by chemotherapy or radiotherapy. Programmed death-ligand 1 (PD-L1 is a trans-membrane protein expressed on a wide variety of cells including immune cells, epithelial and vascular endothelial cells. Recently, PD-1/PD-L1 pathway signaling was described as an adaptive immune resistance mechanism enacted by the tumor cells to evade the immune response. Its presence on tumor cell membranes, acquired for this reason, through time, is an important prognostic value. However, data available in the literature about PD-L1 immunohistochemical expression in breast cancer are often discordant and not uniform, probably for the use of different antibodies clones and the high molecular heterogeneity of the different tumor types. The absence of target therapies, in particular for TNBC, has shifted the clinical attention mainly on the role of PD-L1 in this subtype of breast cancer. In this study, we evaluated tumor and TIL (tumor infiltrating lymphocytes PDL-1 expression in a series of TNBC, included in Tissue Micro Arrays (TMAs, to define its real prognostic value, optimizing immunohistochemistry method with an “approved for diagnostic assay” antibody. PD-L1 expression directly correlated with proliferation index (Ki-67, glycemia, the presence of diabetes and indirectly with menopausal status, presence of lymph node metastasis and relapse. The analysis of Kaplan–Meier showed that an increased PD-L1 expression was strongly associated with better disease-free survival (DFS but not correlated with overall survival (OS. Our data confirmed that PD-L1 could be an important marker for prognostic stratification and for planning immune checkpoint inhibitors therapies in patients with TNBC.

  6. A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1.

    Science.gov (United States)

    Uemura, Marc; Faisal, Faa'k; Haymaker, Cara; McQuail, Natalie; Sirmans, Elizabeth; Hudgens, Courtney W; Barbara, Lydia; Bernatchez, Chantale; Curry, Jonathan L; Hwu, Patrick; Tetzlaff, Michael T; Diab, Adi

    2016-01-01

    Immune related adverse events (irAEs) are common side effects of checkpoint inhibitory (CPI) therapies targeting CTLA-4 and PD-1/PD-L1. Grover's disease is an uncommon dermatologic condition with unclear pathogenesis previously reported as an irAE with ipilimumab. We report an additional case of ipilimumab-induced Grover's disease. Interestingly, this dermatologic side effect did not appear with use of anti-PD-1 therapy in our patient. Immune analysis was performed and suggests a possible role of Th2 cells in its patholgenesis. This case suggests that Grover's disease is an irAE induced by Ipilimumab. Our immune analysis suggests that Th2 cells may be pathogenic mediators which warrants further study.

  7. Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population: The Japan Morning Surge-Home Blood Pressure Study.

    Science.gov (United States)

    Hoshide, Satoshi; Yano, Yuichiro; Haimoto, Hajime; Yamagiwa, Kayo; Uchiba, Kiyoshi; Nagasaka, Shoichiro; Matsui, Yoshio; Nakamura, Akira; Fukutomi, Motoki; Eguchi, Kazuo; Ishikawa, Joji; Kario, Kazuomi

    2016-07-01

    Our aim is to determine the optimal time schedule for home blood pressure (BP) monitoring that best predicts stroke and coronary artery disease in general practice. The Japan Morning Surge-Home Blood Pressure (J-HOP) study is a nationwide practice-based study that included 4310 Japanese with a history of or risk factors for cardiovascular disease, or both (mean age, 65 years; 79% used antihypertensive medication). Home BP measures were taken twice daily (morning and evening) over 14 days at baseline. During a mean follow-up of 4 years (16 929 person-years), 74 stroke and 77 coronary artery disease events occurred. Morning systolic BP (SBP) improved the discrimination of incident stroke (C statistics, 0.802; 95% confidence interval, 0.692-0.911) beyond traditional risk factors including office SBP (0.756; 0.646-0.866), whereas the changes were smaller with evening SBP (0.764; 0.653-0.874). The addition of evening SBP to the model (including traditional risk factors plus morning SBP) significantly reduced the discrimination of incident stroke (C statistics difference, -0.008; 95% confidence interval: -0.015 to -0.008; P=0.03). The category-free net reclassification improvement (0.3606; 95% confidence interval, 0.1317-0.5896), absolute integrated discrimination improvement (0.015; SE, 0.005), and relative integrated discrimination improvement (58.3%; all Pmorning SBP to the model (including traditional risk factors) were greater than those with evening SBP and with combined morning and evening SBP. Neither morning nor evening SBP improved coronary artery disease risk prediction. Morning home SBP itself should be evaluated to ensure best stroke prediction in clinical practice, at least in Japan. This should be confirmed in the different ethnic groups. URL: http://www.umin.ac.jp/ctr/. Unique identifier: UMIN000000894. © 2016 American Heart Association, Inc.

  8. Characterization of the Xylella fastidiosa PD1671 gene encoding degenerate c-di-GMP GGDEF/EAL domains, and its role in the development of Pierce's disease.

    Science.gov (United States)

    Cursino, Luciana; Athinuwat, Dusit; Patel, Kelly R; Galvani, Cheryl D; Zaini, Paulo A; Li, Yaxin; De La Fuente, Leonardo; Hoch, Harvey C; Burr, Thomas J; Mowery, Patricia

    2015-01-01

    Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce's disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of cell aggregates and bacterial biofilms. Here we examine the role in X. fastidiosa virulence of an uncharacterized gene, PD1671, annotated as a two-component response regulator with potential GGDEF and EAL domains. GGDEF domains are found in c-di-GMP diguanylate cyclases while EAL domains are found in phosphodiesterases, and these domains are for c-di-GMP production and turnover, respectively. Functional analysis of the PD1671 gene revealed that it affected multiple X. fastidiosa virulence-related phenotypes. A Tn5 PD1671 mutant had a hypervirulent phenotype in grapevines presumably due to enhanced expression of gum genes leading to increased exopolysaccharide levels that resulted in elevated biofilm formation. Interestingly, the PD1671 mutant also had decreased motility in vitro but did not show a reduced distribution in grapevines following inoculation. Given these responses, the putative PD1671 protein may be a negative regulator of X. fastidiosa virulence.

  9. Community health facility preparedness for a cholera surge in Haiti.

    Science.gov (United States)

    Mobula, Linda Meta; Jacquet, Gabrielle A; Weinhauer, Kristin; Alcidas, Gladys; Thomas, Hans-Muller; Burnham, Gilbert

    2013-01-01

    With increasing population displacement and worsening water insecurity after the 2010 earthquake, Haiti experienced a large cholera outbreak. Our goal was to evaluate the strengths and weaknesses of seven community health facilities' ability to respond to a surge in cholera cases. Since 2010, Catholic Relief Services (CRS) with a number of public and private donors has been working with seven health facilities in an effort to reduce morbidity and mortality from cholera infection. In November 2012, CRS through the Centers for Disease Control and Prevention (CDC)'s support, asked the Johns Hopkins Center for Refugee and Disaster Response to conduct a cholera surge simulation tabletop exercise at these health facilities to improve each facility's response in the event of a cholera surge. Using simulation development guidelines from the Pan American Health Organization and others, a simulation scenario script was produced that included situations of differing severity, supply chain, as well as a surge of patients. A total of 119 hospital staff from seven sites participated in the simulation exercise including community health workers, clinicians, managers, pharmacists, cleaners, and security guards. Clinics that had challenges during the simulated clinical care of patients were those that did not appropriately treat all cholera patients according to protocol, particularly those that were vulnerable, those that would need additional staff to properly treat patients during a surge of cholera, and those that required a better inventory of supplies. Simulation-based activities have the potential to identify healthcare delivery system vulnerabilities that are amenable to intervention prior to a cholera surge.

  10. Inter-rater variability in motor function assessment in Parkinson's disease between experts in movement disorders and nurses specialising in PD management.

    Science.gov (United States)

    de Deus Fonticoba, T; Santos García, D; Macías Arribí, M

    2017-05-23

    In clinical practice, assessing patients with Parkinson's disease (PD) is a complex, time-consuming task. Our purpose is to provide a rigorous and objective evaluation of how motor function in PD patients is assessed by neurologists specialising in movement disorders, on the one hand, and by nurses specialising in PD management, on the other. We conducted an observational, cross-sectional, single-centre study of 50 patients with PD (52% men; mean age: 64.7 ± 8.7 years) who were assessed between 5 January 2016 and 20 July 2016. A neurologist and a nurse evaluated motor function in the early morning hours using the Unified Parkinson's Disease Rating Scale (UPDRS) parts III and IV and Hoehn & Yahr (H&Y) scale. Tests were administered in the same PD periods (in 48 patients during the 'off' time and in 2 patients during the 'on' time). Inter-rater variability was estimated with the intraclass correlation coefficient (ICC). Forty-nine patients (98%) were classified in the same H&Y stage by both raters. Assessment times were similar for both raters. ICC for UPDRS-IV and UPDRS-III total scores were 0.955 (Pde Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Reconnaissance level study Mississippi storm surge barrier

    NARCIS (Netherlands)

    Van Ledden, M.; Lansen, A.J.; De Ridder, H.A.J.; Edge, B.

    2012-01-01

    This paper reports a reconnaissance level study of a storm surge barrier in the Mississippi River. Historical hurricanes have shown storm surge of several meters along the Mississippi River levees up to and upstream of New Orleans. Future changes due to sea level rise and subsidence will further

  12. The dynamics of surge in compression systems

    Indian Academy of Sciences (India)

    47. Figure 4. Time series (a) and corresponding frequency spectra plot (b) indicating surge. of surge, flow visualisation studies, another setup was fabricated with a piston, cylinder configuration, with which volume of the plenum could be changed continuously. Different lengths of compressor duct were used in the study.

  13. The dynamics of surge in compression systems

    Indian Academy of Sciences (India)

    Even though the experimental work of Grietzer (1976) was quite in conformity with his theory, the parameter B,could ... It was reported by Day (1994) that during experimental work on stall and surge, oscillations at the system natural frequency ... In other words, deep surge cycles are similar to relaxation oscillations exhibited ...

  14. Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX): a multifunctional protein involved in central nervous system development and disease.

    Science.gov (United States)

    Dennis, Jameel; Nogaroli, Luciana; Fuss, Babette

    2005-12-15

    Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX) was originally identified as a cell-motility-stimulating factor secreted by a variety of tumor cells. Thus, studies related to its potential functional roles have traditionally focused on tumorigenesis. PD-Ialpha/ATX's catalytic activity, initially defined as nucleotide pyrophosphatase/phosphodiesterase, was soon recognized as being necessary for its tumor cell-motility-stimulating activity. However, only the discovery of PD-Ialpha/ATX's identity with lysophospholipase D, an extracellular enzyme that converts lysophosphatidylcholine into lysophosphatidic acid (LPA) and potentially sphingosylphosphoryl choline into sphingosine 1-phosphate (S1P), revealed the actual effectors responsible for PD-Ialpha/ATX's ascribed motogenic functions, i.e., its catalytic products. PD-Ialpha/ATX has also been detected during normal development in a number of tissues, in particular, the central nervous system (CNS), where expression levels are high. Similar to tumor cells, PD-Ialpha/ATX-expressing CNS cells secrete catalytically active PD-Ialpha/ATX into the extracellular environment. Thus, it appears reasonable to assume that PD-Ialpha/ATX's CNS-related functions are mediated via lysophospholipid, LPA and potentially S1P, signaling. However, recent studies identified PD-Ialpha/ATX as a matricellular protein involved in the modulation of oligodendrocyte-extracellular matrix interactions and oligodendrocyte remodeling. This property of PD-Ialpha/ATX was found to be independent of its catalytic activity and to be mediated by a novel functionally active domain. These findings, therefore, uncover PD-Ialpha/ATX, at least in the CNS, as a multifunctional protein able to induce complex signaling cascades via distinct structure-function domains. This Mini-Review describes PD-Ialpha/ATX's multifunctional roles in the CNS and discusses their potential contributions to CNS development and pathology.

  15. Morning blood pressure surge is associated with arterial stiffness and sympathetic baroreflex sensitivity in hypertensive seniors

    Science.gov (United States)

    Okada, Yoshiyuki; Galbreath, M. Melyn; Shibata, Shigeki; Jarvis, Sara S.; Bivens, Tiffany B.; Vongpatanasin, Wanpen; Levine, Benjamin D.

    2013-01-01

    Morning blood pressure (BP) surge is considered to be an independent risk factor for cardiovascular diseases. We tested the hypothesis that increased large-artery stiffness and impaired sympathetic baroreflex sensitivity (BRS) contribute to augmented morning surge in elderly hypertensive subjects. Morning surge was assessed as morning systolic BP averaged for 2 h just after waking up minus minimal sleeping systolic BP by using ambulatory BP monitoring (ABPM) in 40 untreated hypertensive [68 ± 1 (SE) yr] and 30 normotensive (68 ± 1 yr) subjects. Beat-by-beat finger BP and muscle sympathetic nerve activity (MSNA) were recorded in the supine position and at 60° upright tilt. We assessed arterial stiffness with carotid-to-femoral pulse wave velocity (cfPWV) and sympathetic BRS during spontaneous breathing. Awake and asleep ABPM-BPs and morning surge were higher in hypertensive than normotensive subjects (all P morning surge ≥35 mmHg (median value) had higher cfPWV (11.9 ± 0.5 vs. 9.9 ± 0.4 m/s, P = 0.002) and lower sympathetic BRS (supine: −2.71 ± 0.25 vs. −3.73 ± 0.29, P = 0.011; upright: −2.62 ± 0.22 vs. −3.51 ± 0.35 bursts·100 beats−1·mmHg−1, P = 0.052) than those with morning surge 0.05), while upright total peripheral resistance was higher in hypertensive subjects with greater morning surge than those with lesser morning surge (P = 0.050). Morning surge was correlated positively with cfPWV (r = 0.59, P morning BP surge is associated with arterial stiffness and sympathetic BRS, as well as vasoreactivity during orthostasis in hypertensive seniors. PMID:23832695

  16. The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson's disease.

    Science.gov (United States)

    Masterson-Algar, Patricia; Burton, Christopher R; Brady, Marian C; Nicoll, Avril; Clarke, Carl E; Rick, Caroline; Hughes, Max; Au, Pui; Smith, Christina H; Sackley, Catherine M

    2017-08-29

    The PD COMM trial is a phase III multi-centre randomised controlled trial whose aim is to evaluate the effectiveness and cost-effectiveness of two approaches to speech and language therapy (SLT) compared with no SLT intervention (control) for people with Parkinson's disease who have self-reported or carer-reported problems with their speech or voice. Our protocol describes the process evaluation embedded within the outcome evaluation whose aim is to evaluate what happened at the time of the PD COMM intervention implementation and to provide findings that will assist in the interpretation of the PD COMM trial results. Furthermore, the aim of the PD COMM process evaluation is to investigate intervention complexity within a theoretical model of how the trialled interventions might work best and why. Drawing from the Normalization Process Theory and frameworks for implementation fidelity, a mixed method design will be used to address process evaluation research questions. Therapists' and participants' perceptions and experiences will be investigated via in-depth interviews. Critical incident reports, baseline survey data from therapists, treatment record forms and home practice diaries also will be collected at relevant time points throughout the running of the PD COMM trial. Process evaluation data will be analysed independently of the outcome evaluation before the two sets of data are then combined. To date, there are a limited number of published process evaluation protocols, and few are linked to trials investigating rehabilitation therapies. Providing a strong theoretical framework underpinning design choices and being tailored to meet the complex characteristics of the trialled interventions, our process evaluation has the potential to provide valuable insight into which components of the interventions being delivered in PD COMM worked best (and what did not), how they worked well and why. ISRCTN Registry, ISRCTN12421382 . Registered on 18 April 2016.

  17. Influence of Surge on Extreme Roll Amplitudes

    DEFF Research Database (Denmark)

    Vidic-Perunovic, Jelena; Rognebakke, Olav; Pedersen, Preben Terndrup

    2008-01-01

    on the position of the wave crest relatively to the ship, the ship will be slowed down when she meets the wave. In this paper attempts are made to accurately account for added resistance and additional thrust, applied in order to maintain the ship speed. The surge equilibrium equation has been longitudinally......Interference of the wave-induced ship surge motion with roll dynamics has been studied. The surge motion has been included in a previously derived hydrodynamic roll prediction model in order to account for the ship speed variation due to the longitudinal incident wave pressure force. Depending...

  18. Comparative cardiac pathological changes of Atlantic salmon (Salmo salar L.) affected with heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD)

    DEFF Research Database (Denmark)

    Yousaf, Muhammad Naveed; Koppang, Erling Olaf; Skjødt, Karsten

    2013-01-01

    muscle, liver and pancreas. The main findings of these diseases are necrosis and inflammatory cells infiltrates affecting different regions of the heart. In order to better characterize the cardiac pathology, study of the inflammatory cell characteristics and cell cycle protein expression was undertaken......The heart is considered the powerhouse of the cardiovascular system. Heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD) are cardiac diseases of marine farmed Atlantic salmon (Salmo salar) which commonly affect the heart in addition to the skeletal...

  19. Modeling Storm Surges Using Discontinuous Galerkin Methods

    Science.gov (United States)

    2016-06-01

    STATEMENT Approved for public release; distribution is unlimited 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words ) Storm surges have a...model. One of the governing systems of equations used to model storm surges’ effects is the Shallow Water Equations (SWE). In this thesis, we solve the...fundamental truth, we found the error norm of the implicit method to be minimal. This study focuses on the impacts of a simulated storm surge in La Push

  20. Coastal ecosystems for protection against storm surge

    Digital Repository Service at National Institute of Oceanography (India)

    Mascarenhas, A.

    reservoirs. Channels, lakes, ponds and marshes distribute flood waters, whereas natural topographic depressions can store large volumes of surge water (Fig.2). Unfortunately, such settings are fast diminishing as structures are being located in reclaimed... Hazards", Spl. Vol. of IGC O.P. Varma, G.V. Rajamanickam & Eugene Wilson (eds.), Ind. Geol. Cong., 2010, pp. 135-145. 9 Coastal Ecosystems for Protection against Storm Surge Antonio Mascarenhas National Institute of Oceanography, Dona Paula-403004 (Goa...

  1. Introducing the new BTS Guideline: Management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).

    Science.gov (United States)

    Haworth, Charles S; Floto, R Andres

    2017-11-01

    The new BTS Guidelines for the management of non-tuberculous mycobacterial pulmonary disease combine the best available evidence with expert consensus to generate a set of pragmatic Guidelines, published as a supplement to this issue of Thorax, to assist in the management of these challenging infections. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. Exercise Improves Cognition in Parkinson’s Disease: the PRET-PD Randomized Clinical Trial

    Science.gov (United States)

    David, Fabian J.; Robichaud, Julie A.; Leurgans, Sue E.; Poon, Cynthia; Kohrt, Wendy M.; Goldman, Jennifer G.; Comella, Cynthia L.; Vaillancourt, David E.; Corcos, Daniel M.

    2015-01-01

    Background This paper reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes which were gathered as part of the Progressive Resistance Exercise Training in Parkinson’s disease randomized controlled trial. Methods This study was a prospective, parallel-group, single-center trial. Fifty-one non-demented patients with mild-to-moderate Parkinson’s disease were randomly assigned either to modified Fitness Counts or to Progressive Resistance Exercise, and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention. Results Eighteen patients in modified Fitness Counts and 20 patients in Progressive Resistance Exercise completed the trial. At 12 and at 24 months no differences between groups were observed. At 12 months, relative to baseline, modified Fitness Counts improved on the Digit Span (estimated change, 0.3; Inter-Quartile Range, 0, 0.7; p=0.04) and Stroop (0.3; 0, 0.6; p=0.04), and Progressive Resistance Exercise improved only on the Digit Span (0.7; 0.3, 1; pParkinson’s disease. PMID:26148003

  3. Analysis of Storm Surge in Hong Kong

    Science.gov (United States)

    Kao, W. H.

    2017-12-01

    A storm surge is a type of coastal flood that is caused by low-pressure systems such as tropical cyclones. Storm surges caused by tropical cyclones can be very powerful and damaging, as they can flood coastal areas, and even destroy infrastructure in serious cases. Some serious cases of storm surges leading to more than thousands of deaths include Hurricane Katrina (2005) in New Orleans and Typhoon Haiyan (2013) in Philippines. Hong Kong is a coastal city that is prone to tropical cyclones, having an average of 5-6 tropical cyclones entering 500km range of Hong Kong per year. Storm surges have seriously damaged Hong Kong in the past, causing more than 100 deaths by Typhoon Wanda (1962), and leading to serious damage to Tai O and Cheung Chau by Typhoon Hagupit (2008). To prevent economic damage and casualties from storm surges, accurately predicting the height of storm surges and giving timely warnings to citizens is very important. In this project, I will be analyzing how different factors affect the height of storm surge, mainly using data from Hong Kong. These factors include the windspeed in Hong Kong, the atmospheric pressure in Hong Kong, the moon phase, the wind direction, the intensity of the tropical cyclone, distance between the tropical cyclone and Hong Kong, the direction of the tropical cyclone relative to Hong Kong, the speed of movement of the tropical cyclone and more. My findings will also be compared with cases from other places, to see if my findings also apply for other places.

  4. Global mortality from storm surges is decreasing

    Science.gov (United States)

    Bouwer, Laurens M.; Jonkman, Sebastiaan N.

    2018-01-01

    Changes in society’s vulnerability to natural hazards are important to understand, as they determine current and future risks, and the need to improve protection. Very large impacts including high numbers of fatalities occur due to single storm surge flood events. Here, we report on impacts of global coastal storm surge events since the year 1900, based on a compilation of events and data on loss of life. We find that over the past, more than eight thousand people are killed and 1.5 million people are affected annually by storm surges. The occurrence of very substantial loss of life (>10 000 persons) from single events has however decreased over time. Moreover, there is a consistent decrease in event mortality, measured by the fraction of exposed people that are killed, for all global regions, except South East Asia. Average mortality for storm surges is slightly higher than for river floods, but lower than for flash floods. We also find that for the same coastal surge water level, mortality has decreased over time. This indicates that risk reduction efforts have been successful, but need to be continued with projected climate change, increased rates of sea-level rise and urbanisation in coastal zones.

  5. Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade.

    Science.gov (United States)

    Lipson, Evan J; Lilo, Mohammed T; Ogurtsova, Aleksandra; Esandrio, Jessica; Xu, Haiying; Brothers, Patricia; Schollenberger, Megan; Sharfman, William H; Taube, Janis M

    2017-01-01

    Monoclonal antibodies that block immune regulatory proteins such as programmed death-1 (PD-1) have demonstrated remarkable efficacy in controlling the growth of multiple tumor types. Unresectable or metastatic basal cell carcinoma, however, has largely gone untested. Because PD-Ligand-1 (PD-L1) expression in other tumor types has been associated with response to anti-PD-1, we investigated the expression of PD-L1 and its association with PD-1 expression in the basal cell carcinoma tumor microenvironment. Among 40 basal cell carcinoma specimens, 9/40 (22%) demonstrated PD-L1 expression on tumor cells, and 33/40 (82%) demonstrated PD-L1 expression on tumor-infiltrating lymphocytes and associated macrophages. PD-L1 was observed in close geographic association to PD-1+ tumor infiltrating lymphocytes. Additionally, we present, here, the first report of an objective anti-tumor response to pembrolizumab (anti-PD-1) in a patient with metastatic PD-L1 (+) basal cell carcinoma, whose disease had previously progressed through hedgehog pathway-directed therapy. The patient remains in a partial response 14 months after initiation of therapy. Taken together, our findings provide a rationale for testing anti-PD-1 therapy in patients with advanced basal cell carcinoma, either as initial treatment or after acquired resistance to hedgehog pathway inhibition.

  6. Positive Surge Propagation in Sloping Channels

    Directory of Open Access Journals (Sweden)

    Daniele Pietro Viero

    2017-07-01

    Full Text Available A simplified model for the upstream propagation of a positive surge in a sloping, rectangular channel is presented. The model is based on the assumptions of a flat water surface and negligible energy dissipation downstream of the surge, which is generated by the instantaneous closure of a downstream gate. Under these hypotheses, a set of equations that depends only on time accurately describes the surge wave propagation. When the Froude number of the incoming flow is relatively small, an approximate analytical solution is also proposed. The predictive ability of the model is validated by comparing the model results with the results of an experimental investigation and with the results of a numerical model that solves the full shallow water equations.

  7. Adaptive mesh refinement for storm surge

    KAUST Repository

    Mandli, Kyle T.

    2014-03-01

    An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the GeoClaw framework and compared to ADCIRC for Hurricane Ike along with observed tide gauge data and the computational cost of each model run. © 2014 Elsevier Ltd.

  8. Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan

    Energy Technology Data Exchange (ETDEWEB)

    Liao, C.-M. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China)]. E-mail: cmliao@ntu.edu.tw; Liang, H.-M. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China); Chen, B.-C. [Department of Post-Modern Agriculture, Mingdao University, Changhua, Taiwan 52345 (China); Singh Sher [Center of Genomics Medicine, School of Medicine, National Taiwan University, Taipei, Taiwan 10617 (China); Tsai, J.-W. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China); Chou, Y.-H. [Ecotoxicological Modeling Center, Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617 (China); Lin, W.-T. [Environment Change Research Center, Academia Sinica, Nankang, Taipei, Taiwan 11517 (China)

    2005-05-01

    A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models were developed for arsenic (As) in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. The PBPK/PD model structure consisted of muscle, gill, gut wall, alimentary canal, and liver, which were interconnected by blood circulation. We integrate the target organ concentrations and dynamic response describing uptake, metabolism, and disposition of As and the associated area-under-curve (AUC)-based toxicological dynamics following an acute exposure. The model validations were compared against the field observations from real tilapia farms and previously published uptake/depuration experimental data, indicating that predicted and measured As concentrations in major organs of tilapia were in good agreement. The model was utilized to reasonably simulate and construct a dose-dependent dynamic response between mortality effect and equilibrium target organ concentrations. Model simulations suggest that tilapia gills may serve as a surrogate sensitive biomarker of short-term exposure to As. This integrated As PBPK/PD/AUC model quantitatively estimates target organ concentration and dynamic response in tilapia and is a strong framework for future waterborne metal model development and for refining a biologically-based risk assessment for exposure of aquatic species to waterborne metals under a variety of scenarios. - Integrated toxicity models can identify dynamic responses of fish to arsenic.

  9. Dynamical coupling of PBPK/PD and AUC-based toxicity models for arsenic in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan

    International Nuclear Information System (INIS)

    Liao, C.-M.; Liang, H.-M.; Chen, B.-C.; Singh Sher; Tsai, J.-W.; Chou, Y.-H.; Lin, W.-T.

    2005-01-01

    A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models were developed for arsenic (As) in tilapia Oreochromis mossambicus from blackfoot disease area in Taiwan. The PBPK/PD model structure consisted of muscle, gill, gut wall, alimentary canal, and liver, which were interconnected by blood circulation. We integrate the target organ concentrations and dynamic response describing uptake, metabolism, and disposition of As and the associated area-under-curve (AUC)-based toxicological dynamics following an acute exposure. The model validations were compared against the field observations from real tilapia farms and previously published uptake/depuration experimental data, indicating that predicted and measured As concentrations in major organs of tilapia were in good agreement. The model was utilized to reasonably simulate and construct a dose-dependent dynamic response between mortality effect and equilibrium target organ concentrations. Model simulations suggest that tilapia gills may serve as a surrogate sensitive biomarker of short-term exposure to As. This integrated As PBPK/PD/AUC model quantitatively estimates target organ concentration and dynamic response in tilapia and is a strong framework for future waterborne metal model development and for refining a biologically-based risk assessment for exposure of aquatic species to waterborne metals under a variety of scenarios. - Integrated toxicity models can identify dynamic responses of fish to arsenic

  10. Morning blood pressure surge and arterial stiffness in newly diagnosed hypertensive patients.

    Science.gov (United States)

    Kıvrak, Ali; Özbiçer, Süleyman; Kalkan, Gülhan Yüksel; Gür, Mustafa

    2017-06-01

    We aimed to investigate the relationship between the morning blood pressure (BP) surge and arterial stiffness in patients with newly diagnosed hypertension. Three hundred and twenty four (mean age 51.7 ± 11.4 years) patients who had newly diagnosed hypertension with 24 h ambulatory BP monitoring were enrolled. Parameters of arterial stiffness, pulse wave velocity and augmentation index (Aix) were measured by applanation tonometry and aortic distensibility was calculated by echocardiography. Compared with the other groups, pulse wave velocity, day-night systolic BP (SBP) difference (p morning BP surge high group. Aortic distensibility values were significantly lower in morning BP surge high group compared to the other groups (p Morning BP surge was found to be independently associated with pulse wave velocity (β = 0.286, p morning BP surge and arterial stiffness which is a surrogate endpoint for cardiovascular diseases. The inverse relationship between morning BP surge and aortic distensibility and direct relation found in our study is new to the literature.

  11. The dynamics of surge in compression systems

    Indian Academy of Sciences (India)

    In air-compression systems, instabilities occur during operation close to their peak pressure-rise capability. However, the peak efficiency of a compression system lies close to this region of instability. A surge is a violent mode of instability where there is total breakdown of flow in the system and pressure-rise capability is lost ...

  12. Positive feedback stabilization of centrifugal compressor surge

    NARCIS (Netherlands)

    Willems, Frank; Heemels, W.P.M.H.; de Jager, Bram; Stoorvogel, Antonie Arij

    Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to

  13. Dzamboe, PD

    African Journals Online (AJOL)

    Dzamboe, PD. Vol 2, No 2 (2004) - Articles Survey on corrosion management in selected industries in Ghana Abstract · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

  14. Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.

    Science.gov (United States)

    Nagatsu, Toshiharu; Nagatsu, Ikuko

    2016-11-01

    Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline. Since deficiencies of dopamine and noradrenaline in the brain stem, caused by neurodegeneration of dopamine and noradrenaline neurons, are mainly related to non-motor and motor symptoms of Parkinson's disease (PD), we have studied human CA-synthesizing enzymes [TH; BH4-related enzymes, especially GTP-cyclohydrolase I (GCH1); aromatic L-amino acid decarboxylase (AADC); dopamine β-hydroxylase (DBH); and phenylethanolamine N-methyltransferase (PNMT)] and their genes in relation to PD in postmortem brains from PD patients, patients with CA-related genetic diseases, mice with genetically engineered CA neurons, and animal models of PD. We purified all human CA-synthesizing enzymes, produced their antibodies for immunohistochemistry and immunoassay, and cloned all human genes, especially the human TH gene and the human gene for GCH1, which synthesizes BH4 as a cofactor of TH. This review discusses the historical overview of TH, BH4-, and other CA-related enzymes and their genes in relation to the pathophysiology of PD, the development of drugs, such as L-DOPA, and future prospects for drug and gene therapy for PD, especially the potential of induced pluripotent stem (iPS) cells.

  15. Fusion of 110Pd with 110Pd

    International Nuclear Information System (INIS)

    Morawek, W.

    1991-07-01

    In the framework of this thesis the excitation functions of the systems 110 Pd + 110 Pd and 110 Pd + 104 Ru could be measured. The evaporation-residual-nucleus cross sections is deviating from lighter systems dominated by channels, which arise from evaporation of α particles. In the reaction 110 Pd + 110 Pd no xn channels were observed. In comparison to other reactions qualitatively a strong fusion hindrance of this system is shown. (orig./HSI) [de

  16. Characterization of the Xylella fastidiosa PD1671 Gene Encoding Degenerate c-di-GMP GGDEF/EAL Domains, and Its Role in the Development of Pierce’s Disease

    Science.gov (United States)

    Cursino, Luciana; Athinuwat, Dusit; Patel, Kelly R.; Galvani, Cheryl D.; Zaini, Paulo A.; Li, Yaxin; De La Fuente, Leonardo; Hoch, Harvey C.; Burr, Thomas J.; Mowery, Patricia

    2015-01-01

    Xylella fastidiosa is an important phytopathogenic bacterium that causes many serious plant diseases including Pierce’s disease of grapevines. X. fastidiosa is thought to induce disease by colonizing and clogging xylem vessels through the formation of cell aggregates and bacterial biofilms. Here we examine the role in X. fastidiosa virulence of an uncharacterized gene, PD1671, annotated as a two-component response regulator with potential GGDEF and EAL domains. GGDEF domains are found in c-di-GMP diguanylate cyclases while EAL domains are found in phosphodiesterases, and these domains are for c-di-GMP production and turnover, respectively. Functional analysis of the PD1671 gene revealed that it affected multiple X. fastidiosa virulence-related phenotypes. A Tn5 PD1671 mutant had a hypervirulent phenotype in grapevines presumably due to enhanced expression of gum genes leading to increased exopolysaccharide levels that resulted in elevated biofilm formation. Interestingly, the PD1671 mutant also had decreased motility in vitro but did not show a reduced distribution in grapevines following inoculation. Given these responses, the putative PD1671 protein may be a negative regulator of X. fastidiosa virulence. PMID:25811864

  17. Surge detection on an automotive turbocharger during transient phases

    Science.gov (United States)

    Deligant, M.; Danlos, A.; Podevin, P.; Clenci, A.; Guilain, S.

    2017-10-01

    The surge limit on automotive turbocharger needs to be avoided to prevent operations with pressure and mass flow oscillations. Mild surge is accompanied by noise which is disturbing. Deep surge can cause significant loss of engine power and severe drivability issues. It is necessary to know the stationary limit in order to match a turbocharger with an engine, ensuring enough surge margin. However, this choice does not guarantee surge free operation during transient functioning. In this paper, the surge onset of a compressor while closing a downstream valve is studied. Various tests have been carried out varying the closing time, the position of the initial operating point and the volume of the circuit. The inlet and outlet signals of physical parameters are analyzed with spectral and temporal methods in order to define the instant of the surge occurrence.

  18. Atlantic hurricane surge response to geoengineering.

    Science.gov (United States)

    Moore, John C; Grinsted, Aslak; Guo, Xiaoran; Yu, Xiaoyong; Jevrejeva, Svetlana; Rinke, Annette; Cui, Xuefeng; Kravitz, Ben; Lenton, Andrew; Watanabe, Shingo; Ji, Duoying

    2015-11-10

    Devastating floods due to Atlantic hurricanes are relatively rare events. However, the frequency of the most intense storms is likely to increase with rises in sea surface temperatures. Geoengineering by stratospheric sulfate aerosol injection cools the tropics relative to the polar regions, including the hurricane Main Development Region in the Atlantic, suggesting that geoengineering may mitigate hurricanes. We examine this hypothesis using eight earth system model simulations of climate under the Geoengineering Model Intercomparison Project (GeoMIP) G3 and G4 schemes that use stratospheric aerosols to reduce the radiative forcing under the Representative Concentration Pathway (RCP) 4.5 scenario. Global mean temperature increases are greatly ameliorated by geoengineering, and tropical temperature increases are at most half of those temperature increases in the RCP4.5. However, sulfate injection would have to double (to nearly 10 teragrams of SO2 per year) between 2020 and 2070 to balance the RCP4.5, approximately the equivalent of a 1991 Pinatubo eruption every 2 y, with consequent implications for stratospheric ozone. We project changes in storm frequencies using a temperature-dependent generalized extreme value statistical model calibrated by historical storm surges and observed temperatures since 1923. The number of storm surge events as big as the one caused by the 2005 Katrina hurricane are reduced by about 50% compared with no geoengineering, but this reduction is only marginally statistically significant. Nevertheless, when sea level rise differences in 2070 between the RCP4.5 and geoengineering are factored into coastal flood risk, we find that expected flood levels are reduced by about 40 cm for 5-y events and about halved for 50-y surges.

  19. Atlantic hurricane surge response to geoengineering

    Energy Technology Data Exchange (ETDEWEB)

    Moore, John C.; Grinsted, Aslak; Guo, Xiaoran; Yu, Xiaoyong; Jevrejeva, Svetlana; Rinke, Annette; Cui, Xuefeng; Kravitz, Ben; Lenton, Andrew; Watanabe, Shingo; Ji, Duoying

    2015-10-26

    Devastating Atlantic hurricanes are relatively rare events. However their intensity and frequency in a warming world may rapidly increase by a factor of 2-7 for each degree of increase in mean global temperature. Geoengineering by stratospheric sulphate aerosol injection cools the tropics relative to the polar regions, including the hurricane main development region in the Atlantic, suggesting that geoengineering may be an effective method of controlling hurricanes. We examine this hypothesis using 8 Earth System Model simulations of climate under the GeoMIP G3 and G4 schemes that use stratospheric aerosols to reduce the radiative forcing under the RCP4.5 scenario. Global mean temperature increases are greatly ameliorated by geoengineering, and tropical temperature increases are at most half of those in RCP4.5, but sulphate injection would have to double between 2020 and 2070 to balance RCP 4.5 to nearly 10 Tg SO2 yr-1, with consequent implications for damage to stratospheric ozone. We project changes in storm frequencies using a temperature-dependent Generalized Extreme Value statistical model calibrated by historical storm surges from 1923 and observed temperatures. The numbers of storm surge events as big as the one that caused the 2005 Katrina hurricane are reduced by about 50% compared with no geoengineering, but this is only marginally statistically significant. However, when sea level rise differences at 2070 between RCP4.5 and geoengineering are factored in to coastal flood risk, we find that expected flood levels are reduced by about 40 cm for 5 year events and perhaps halved for 50 year surges.

  20. Hospital Bioterrorism Planning and Burn Surge

    Science.gov (United States)

    Myers, Brent; Cairns, Charles B.; Rich, Preston B.; Hultman, C. Scott; Charles, Anthony G.; Jones, Samuel W.; Schmits, Grace L.; Skarote, Mary Beth; Holmes, James H.; Cairns, Bruce A.

    2014-01-01

    On the morning of June 9, 2009, an explosion occurred at a manufacturing plant in Garner, North Carolina. By the end of the day, 68 injured patients had been evaluated at the 3 Level I trauma centers and 3 community hospitals in the Raleigh/Durham metro area (3 people who were buried in the structural collapse died at the scene). Approximately 300 employees were present at the time of the explosion, when natural gas being vented during the repair of a hot water heater ignited. The concussion from the explosion led to structural failure in multiple locations and breached additional natural gas, electrical, and ammonia lines that ran overhead in the 1-story concrete industrial plant. Intent is the major difference between this type of accident and a terrorist using an incendiary device to terrorize a targeted population. But while this disaster lacked intent, the response, rescue, and outcomes were improved as a result of bioterrorism preparedness. This article discusses how bioterrorism hospital preparedness planning, with an all-hazards approach, became the basis for coordinated burn surge disaster preparedness. This real-world disaster challenged a variety of systems, hospitals, and healthcare providers to work efficiently and effectively to manage multiple survivors. Burn-injured patients served as a focus for this work. We describe the response, rescue, and resuscitation provided by first responders and first receivers as well as efforts made to develop burn care capabilities and surge capacity. PMID:24527874

  1. Compressor Surge Control Design Using Linear Matrix Inequality Approach

    OpenAIRE

    Uddin, Nur; Gravdahl, Jan Tommy

    2017-01-01

    A novel design for active compressor surge control system (ASCS) using linear matrix inequality (LMI) approach is presented and including a case study on piston-actuated active compressor surge control system (PAASCS). The non-linear system dynamics of the PAASCS is transformed into linear parameter varying (LPV) system dynamics. The system parameters are varying as a function of the compressor performance curve slope. A compressor surge stabilization problem is then formulated as a LMI probl...

  2. PD-1/PD-L signaling pathway in chronic hepatitis B

    Directory of Open Access Journals (Sweden)

    TAO Lilin

    2016-12-01

    Full Text Available Hepatitis B is one of the major diseases that affect the health of Chinese people, and chronic hepatitis B virus (HBV infection can lead to disease progression. Programmed death-1 (PD-1 discovered in recent years is an important coordinated stimulus molecule which belongs to the B7/CD28 family. After its binding with programmed death ligand (PD-L, it can regulate the activation, differentiation, and proliferation of T lymphocytes. PD-1 and its ligand are differently expressed in different stages of chronic HBV infection. The interaction between PD-1 and its ligand in different immune cells induces immune tolerance in human body and finally leads to the chronicity of HBV infection. Blocking the PD-1/PD-L signaling pathway through different ways can improve T cell exhaustion, suggesting that this might be one of the directions of antiviral therapy in future.

  3. Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: a pilot randomised controlled trial (PD COMM pilot).

    Science.gov (United States)

    Sackley, Catherine M; Smith, Christina H; Rick, Caroline E; Brady, Marian C; Ives, Natalie; Patel, Smitaa; Woolley, Rebecca; Dowling, Francis; Patel, Ramilla; Roberts, Helen; Jowett, Sue; Wheatley, Keith; Kelly, Debbie; Sands, Gina; Clarke, Carl E

    2018-01-01

    Speech-related problems are common in Parkinson's disease (PD), but there is little evidence for the effectiveness of standard speech and language therapy (SLT) or Lee Silverman Voice Treatment (LSVT LOUD®). The PD COMM pilot was a three-arm, assessor-blinded, randomised controlled trial (RCT) of LSVT LOUD®, SLT and no intervention (1:1:1 ratio) to assess the feasibility and to inform the design of a full-scale RCT. Non-demented patients with idiopathic PD and speech problems and no SLT for speech problems in the past 2 years were eligible. LSVT LOUD® is a standardised regime (16 sessions over 4 weeks). SLT comprised individualised content per local practice (typically weekly sessions for 6-8 weeks). Outcomes included recruitment and retention, treatment adherence, and data completeness. Outcome data collected at baseline, 3, 6, and 12 months included patient-reported voice and quality of life measures, resource use, and assessor-rated speech recordings. Eighty-nine patients were randomised with 90% in the therapy groups and 100% in the control group completing the trial. The response rate for Voice Handicap Index (VHI) in each arm was ≥ 90% at all time-points. VHI was highly correlated with the other speech-related outcome measures. There was a trend to improvement in VHI with LSVT LOUD® (difference at 3 months compared with control: - 12.5 points; 95% CI - 26.2, 1.2) and SLT (difference at 3 months compared with control: - 9.8 points; 95% CI - 23.2, 3.7) which needs to be confirmed in an adequately powered trial. Randomisation to a three-arm trial of speech therapy including a no intervention control is feasible and acceptable. Compliance with both interventions was good. VHI and other patient-reported outcomes were relevant measures and provided data to inform the sample size for a substantive trial. International Standard Randomised Controlled Trial Number Register: ISRCTN75223808. registered 22 March 2012.

  4. Tide-surge interaction in the English Channel

    Directory of Open Access Journals (Sweden)

    D. Idier

    2012-12-01

    Full Text Available The English Channel is characterised by strong tidal currents and a wide tidal range, such that their influence on surges is expected to be non-negligible. In order to better assess storm surges in this zone, tide-surge interactions are investigated. A preliminary data analysis on hourly surges indicates some preferential times of occurrence of large storm surges at rising tide, especially in Dunkerque. To examine this further, a numerical modelling approach is chosen, based on the 2DH shallow-water model (MARS. The surges are computed both with and without tide interaction. For the two selected events (the November 2007 North Sea and March 2008 Atlantic storms, it appears that the instantaneous tide-surge interaction is seen to be non-negligible in the eastern half of the English Channel, reaching values of 74 cm (i.e. 50% of the same event maximal storm surge in the Dover Strait for the studied cases. This interaction decreases in westerly direction. In the risk-analysis community in France, extreme water levels have been determined assuming skew surges and tide as independent. The same hydrodynamic model is used to investigate this dependence in the English Channel. Simple computations are performed with the same meteorological forcing, while varying the tidal amplitude, and the skew surge differences DSS are analysed. Skew surges appear to be tide-dependent, with negligible values of DSS (<0.05 m over a large portion of the English Channel, although reaching several tens of centimetres in some locations (e.g. the Isle of Wight and Dover Strait.

  5. Control of the LH surge mechanism in the female pig.

    Science.gov (United States)

    Elsaesser, F; Parvizi, N; Foxcroft, G R

    1992-12-01

    The functionality of the oestrogen-positive feedback mechanism is the basis for the preovulatory LH surge and thus for regular cyclic activity in the sow. The LH surge mechanism (LH SM) gradually matures as a function of age, immature gilts display delayed, low amplitude LH surges in response to oestradiol benzoate (OB). The maturation of the LH SM apparently is ovarian oestrogen-dependent. Continuous ovarian secretions, probably oestrogens, also appear to be necessary for the final peripubertal maturation of the LH SM and to maintain the functionality of this mechanism in the sexually mature gilt. Superphysiological levels of oestrogens are, however, detrimental to the development of the LH SM. Failure of various infusions of the opioid antagonist naloxone during the surge period to enhance the magnitude of OB-induced LH surges in immature gilts does not support the idea, that central opioidergic systems are of major importance in preventing mature LH surge response at this age. However, opioids could be involved in the termination of the LH surge. Experiments using the opioid agonist morphine and the antagonist naloxone to demonstrate that opioids are involved in the generation of the LH surge in the mature gilt have so far provided equivocal data. Studies using pulsatile infusions of LHRH or of a potent LHRH-agonist during the surge period in OB-treated immature gilts, in which endogenous LHRH release was blocked by methallibure, suggest that oestradiol fails to generate mature LH surges because the gonadotrophs of the immature gilt are unable to respond to enhanced LHRH secretion during the surge period in an adult-like manner. During early lactation the LH SM cannot be activated by OB, while during late lactation a partial recovery of the LH SM occurs. Minor breed differences exist in the functionality of the LH SM during lactation between LW sows and highly fertile Chinese Meishan sows, in which lactational anoestrus is not obligatory.

  6. Will oscillating wave surge converters survive tsunamis?

    Directory of Open Access Journals (Sweden)

    L. O’Brien

    2015-07-01

    Full Text Available With an increasing emphasis on renewable energy resources, wave power technology is becoming one of the realistic solutions. However, the 2011 tsunami in Japan was a harsh reminder of the ferocity of the ocean. It is known that tsunamis are nearly undetectable in the open ocean but as the wave approaches the shore its energy is compressed, creating large destructive waves. The question posed here is whether an oscillating wave surge converter (OWSC could withstand the force of an incoming tsunami. Several tools are used to provide an answer: an analytical 3D model developed within the framework of linear theory, a numerical model based on the non-linear shallow water equations and empirical formulas. Numerical results show that run-up and draw-down can be amplified under some circumstances, leading to an OWSC lying on dry ground!

  7. The nocturnal thyroid-stimulating hormone surge is absent in overt, present in mild primary and equivocal in central hypothyroidism

    NARCIS (Netherlands)

    Adriaanse, R.; Romijn, J. A.; Endert, E.; Wiersinga, W. M.

    1992-01-01

    The nocturnal TSH surge was studied in controls, in 34 patients with hypothalamic/pituitary disease and in 21 patients with primary hypothyroidism. It was absent in 5/12 hypothyroid patients and in 5/22 euthyroid patients with hypothalamic/pituitary disease (42% vs 23%, NS). Central hypothyroidism

  8. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis.

    Science.gov (United States)

    Liang, Spencer C; Greenwald, Rebecca J; Latchman, Yvette E; Rosas, Lucia; Satoskar, Abhay; Freeman, Gordon J; Sharpe, Arlene H

    2006-01-01

    To compare the roles of programmed death 1 ligand 1 (PD-L1) and PD-L2 in regulating immunity to infection, we investigated responses of mice lacking PD-L1 or PD-L2 to infection with Leishmania mexicana. PD-L1(-/-) and PD-L2(-/-) mice exhibited distinct disease outcomes following infection with L. mexicana. In comparison to susceptible WT mice, PD-L1(-/-) mice showed resistance to L. mexicana, as demonstrated by reduced growth of cutaneous lesions and parasite burden. In contrast, PD-L2(-/-) mice developed exacerbated disease with increased parasite burden. Host resistance to L. mexicana is partly associated with the development of a Th1 response and down-regulation of the Th2 response. Both PD-L1(-/-) and PD-L2(-/-) mice produced levels of IFN-gamma similar to WT mice. However, the development of IL-4-producing cells was reduced in PD-L1(-/-) mice, demonstrating a role for PD-L1 in regulating Th cell differentiation. This inadequate Th2 response may explain the increased resistance of PD-L1(-/-) mice. Although no alterations in Th1/Th2 skewing were observed in PD-L2(-/-) mice, PD-L2(-/-) mice exhibited a marked increase in L. mexicana-specific antibody production. Increased Leishmania-specific IgG production may suppress the healing response through FcgammaR ligation on macrophages. Taken together, our results demonstrate that PD-L1 and PD-L2 have distinct roles in regulating the immune response to L. mexicana.

  9. The central biobank and virtual biobank of BiOMarKaPD: a resource for studies on neurodegenerative diseases

    NARCIS (Netherlands)

    Reijs, B.L.R.; Teunissen, C.E.; Goncharenko, N.; Betsou, F.; Blennow, K.; Baldeiras, I.; Brosseron, F.; Cavedo, E.; Fladby, T.; Froelich, L.; Gabryelewicz, T.; Gurvit, H.; Kapaki, E.; Koson, P.; Kulic, L.; Lehmann, S.; Lewczuk, P.; Lleo, A.; Maetzler, W.; de Mendonca, A.; Miller, A.M.; Molinuevo, J.L.; Mollenhauer, B.; Parnetti, L.; Rot, U.; Schneider, A.; Simonsen, A.H.; Tagliavini, F.; Tsolaki, M.; Verbeek, M.M.; Verhey, F. R. J.; Zboch, M.; Winblad, B.; Scheltens, P.; Zetterberg, H.; Visser, P.J.

    2015-01-01

    Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid

  10. Scenario-based Storm Surge Vulnerability Assessment of Catanduanes

    Science.gov (United States)

    Suarez, J. K. B.

    2015-12-01

    After the devastating storm surge effect of Typhoon Haiyan, the public recognized an improved communication about risks, vulnerabilities and what is threatened by storm surge. This can be provided by vulnerability maps which allow better visual presentations and understanding of the risks and vulnerabilities. Local implementers can direct the resources needed for protection of these areas. Moreover, vulnerability and hazard maps are relevant in all phases of disaster management designed by the National Disaster Risk Reduction Council (NDRRMC) - disaster preparedness, prevention and mitigation and response and recovery and rehabilitation. This paper aims to analyze the vulnerability of Catanduanes, a coastal province in the Philippines, to storm surges in terms of four parameters: population, built environment, natural environment and agricultural production. The vulnerability study relies on the storm surge inundation maps based on the Department of Science and Technology Nationwide Operational Assessment of Hazards' (DOST-Project NOAH) proposed four Storm Surge Advisory (SSA) scenarios (1-2, 3, 4, and 5 meters) for predicting storm surge heights. To determine total percent affected for each parameter elements, an overlay analysis was performed in ArcGIS Desktop. Moreover, vulnerability and hazard maps are generated as a final output and a tool for visualizing the impacts of storm surge event at different surge heights. The result of this study would help the selected province to know their present condition and adapt strategies to strengthen areas where they are found to be most vulnerable in order to prepare better for the future.

  11. ISSN 2073-9990 East Cent Afr J Surg

    African Journals Online (AJOL)

    Patient Saf Surg. 2011;5:27-30. 8. Ajape AA, Obiano SK, Ibrahim A. Enterocutaneous fistula: An usual complication of suprapubic cystostomy. Niger J Surg Res. 2005;7:199–203. 9. Islam S, Barai KP. Suprapubic catheterisation complicated by iatrogenic enterocutaneous fistula. Cases J. 2009;2:9311-9315. 10. Levrant SG ...

  12. A novel parameter estimation method for metal oxide surge arrester ...

    Indian Academy of Sciences (India)

    45 and 60μs, is 2–4% lower than that of a 8μs current impulse (Martinez & Durbak 2005). In order to reproduce the MO surge arrester dynamic characteristics mentioned previously, a lot of researches have been done on modelling and simulation of MO surge arresters (Martinez. & Durbak 2005). A dynamic model has been ...

  13. A novel parameter estimation method for metal oxide surge arrester ...

    Indian Academy of Sciences (India)

    with experimental results. Keywords. Metal oxide surge arrester models; PSO; ACO; parameter estimation;. EMTP. 1. Introduction. Metal oxide (MO) surge arresters are widely used as protective devices against switching and lightning over-voltages in power systems. The proper nonlinear voltage-current characteristics,. ∗.

  14. Uncertainties in storm surge and coastal inundation modeling

    Science.gov (United States)

    Dukhovskoy, D. S.; Morey, S. L.

    2011-12-01

    Storm surge modeling has developed noticeably over the past two decades marching from relatively simple two-dimensional models with simplified physics and coarse computational grid to three-dimensional complex modeling systems with wetting and drying capabilities and high-resolution grids. Although the physics of a storm surge is conceptually straight forward, it is still a challenge to provide an accurate numerical forecast of a storm surge. The presentation will focus on sources of uncertainties in storm surge modeling based on several real-case simulations of the storm surge in the Gulf of Mexico. An ongoing study on estimating the likelihood of coastal inundation along the U.S. Gulf coast will be presented.

  15. Integrated warning system for tsunami and storm surges in China

    International Nuclear Information System (INIS)

    Yang Huating

    1989-01-01

    Tsunami and storm surges result in unusual oscillation of seal level, flooding the coastal zones and constitute the major marine disasters in China. Damage by storm surges occurs frequently. According to statistics there are 14 storm surge events exceeding 1 every year on the average. Six of them are typhoon surges and the other eight are extra-tropical surges. In general, in China, there is one severe disaster of storm surge every two years. Monitoring, forecasting and warning for storm surges, including the drop of water level, are the major part of the operational oceanographic services in China. Such a warning system has been set up and is operated by the State Oceanic Administration since 1974. The results of the historical study of tsunami in the last few years pointed out that the anomaly of sea level generated by tele-tsunamis originating in the Pacific Ocean Basin is less than 30 cm on the mainland coast, but local tsunami in the China Seas can be very dangerous. For example, more than 50,000 people were killed by a tsunami in Taiwan and in Taiwan Strait in 1781. It resulted in more deaths than any other tsunami in recorded history. However, the frequency of tsunami disaster is very low for the coast of China, averaging only one every 100 years. It is impossible to set up an independent tsunami warning system in China. It is more practical to set up an integrated warning system on tsunami and on storm surges consisting of: A sea level observing network with real time sea level data acquisition capability; A monitoring system of weather causing the storm surges and of seismic stations monitoring tsunamigenic earthquakes; A tidal prediction scheme for operational use; A forecasting scheme for storm surges and tsunami analysis; The means for warning dissemination. (author). 8 refs, 4 figs, 3 tabs

  16. Storm Surge and Tide Interaction: A Complete Paradigm

    Science.gov (United States)

    Horsburgh, K.

    2014-12-01

    Estimates show that in 2005, in the largest 136 coastal cities, there were 40 million people and 3,000 billion of assets exposed to 1 in 100 year coastal flood events. Mean sea level rise will increase this exposure to 150 million people and 35,000 billion of assets by 2070. Any further change in the statistics of flood frequency or severity would impact severely on economic and social systems. It is therefore crucial to understand the physical drivers of extreme storm surges, and to have confidence in datasets used for extreme sea level statistics. Much previous research has focussed on the process of tide-surge interaction, and it is now widely accepted that the physical basis of tide-surge interaction is that a phase shift of the tidal signal represents the effect of the surge on the tide. The second aspect of interaction is that shallow water momentum considerations imply that differing tidal states should modulate surge generation: wind stress should have greater surge-generating potential on lower tides. We present results from a storm surge model of the European shelf that demonstrate that tidal range does have an effect on the surges generated. The cycle-integrated effects of wind stress (i.e. the skew surge) are greater when tidal range is low. Our results contradict the absence of any such correlation in tide gauge records. This suggests that whilst the modulating effect of the tide on the skew surge (the time-independent difference between peak prediction and observations) is significant, the difference between individual storms is dominant. This implies that forecasting systems must predict salient detail of the most intense storms. A further implication is that flood forecasting models need to simulate tides with acceptable accuracy at all coastal locations. We extend our model analysis to show that the same modulation of storm surges (by tidal conditions) applies to tropical cyclones. We conduct simulations using a mature operational storm surge model

  17. Neurosteroids, trigger of the LH surge

    Science.gov (United States)

    Kuo, John; Micevych, Paul

    2012-01-01

    Recent experiments from our laboratory are consistent with the idea that hypothalamic astrocytes are critical components of the central nervous system (CNS) mediated estrogen positive feedback mechanism. The “astrocrine hypothesis” maintains that ovarian estradiol rapidly increases free cytoplasmic calcium concentrations ([Ca2+]i) that facilitate progesterone synthesis in astrocytes. This hypothalamic neuroprogesterone along with the elevated estrogen from the ovaries allows for the surge release of gonadotropin-releasing hormone (GnRH) that triggers the pituitary luteinizing hormone (LH) surge. A narrow range of estradiol stimulated progesterone production supports an “off-on-off” mechanism regulating the transition from estrogen negative feedback to estrogen positive feedback, and back again. The rapidity of the [Ca2+]i response and progesterone synthesis support a non-genomic, membrane-initiated signaling mechanism. In hypothalamic astrocytes, membrane-associated estrogen receptors (mERs) signal through transactivation of the metabotropic glutamate receptor type 1a (mGluR1a), implying that astrocytic function is influenced by surrounding glutamatergic nerve terminals. Although other putative mERs, such as mERβ, STX-activated mER-Gαq, and G protein-coupled receptor 30 (GPR30), are present and participate in membrane-mediated signaling, their influence in reproduction is still obscure since female reproduction be it estrogen positive feedback or lordosis behavior requires mERα. The astrocrine hypothesis is also consistent with the well-known sexual dimorphism of estrogen positive feedback. In rodents, only post-pubertal females exhibit this positive feedback. Hypothalamic astrocytes cultured from females, but not males, responded to estradiol by increasing progesterone synthesis. Estrogen autoregulates its own signaling by regulating levels of mERα in the plasma membrane of female astrocytes. In male astrocytes, the estradiol-induced increase in m

  18. Surge dynamics on Bering Glacier, Alaska, in 2008–2011

    Directory of Open Access Journals (Sweden)

    M. Braun

    2012-11-01

    Full Text Available A surge cycle of the Bering Glacier system, Alaska, is examined using observations of surface velocity obtained using synthetic aperture radar (SAR offset tracking, and elevation data obtained from the University of Alaska Fairbanks LiDAR altimetry program. After 13 yr of quiescence, the Bering Glacier system began to surge in May 2008 and had two stages of accelerated flow. During the first stage, flow accelerated progressively for at least 10 months and reached peak observed velocities of ~ 7 m d−1. The second stage likely began in 2010. By 2011 velocities exceeded 9 m d−1 or ~ 18 times quiescent velocities. Fast flow continued into July 2011. Surface morphology indicated slowing by fall 2011; however, it is not entirely clear if the surge is yet over. The quiescent phase was characterized by small-scale acceleration events that increased driving stresses up to 70%. When the surge initiated, synchronous acceleration occurred throughout much of the glacier length. Results suggest that downstream propagation of the surge is closely linked to the evolution of the driving stress during the surge, because driving stress appears to be tied to the amount of resistive stress provided by the bed. In contrast, upstream acceleration and upstream surge propagation is not dependent on driving stress evolution.

  19. From the axons of the SNc dopamine neurons to their dendritic processes: further clues to susceptibility in Parkinson’s disease (PD?

    Directory of Open Access Journals (Sweden)

    Eleftheria Kyriaki Pissadaki

    2014-04-01

    Full Text Available Dopamine neurons of the substantia nigra pars compacta (SNc are uniquely sensitive to degeneration in Parkinson’s disease (PD and its models. Although a variety of molecular characteristics have been proposed to underlie this sensitivity, one possible contributory factor is their massive, unmyelinated, axonal arbor that is orders of magnitude larger than other neuronal types. In our previously published work, we examined the energetic impact imposed on SNc dopamine neurons by their extensive, unmyelinated axonal arbor and attempted to calculate the energy cost of action potential (AP propagation throughout the axonal arbors. Among our main findings were that a the energy demand associated with AP conduction is related in a supra-linear manner to the axonal size and complexity and, b that synaptic stimulation is necessary to ensure reliable propagation throughout the axonal arbors of neurons with higher levels of branching. Indeed, predictions of our biophysical model of SNc dopamine neurons suggest that tonic activity for the reliable propagation of APs throughout the axonal arbour of neurons with small-to-moderate size arbours, whereas synaptic stimulation is required for for reliable propagation in neurons with larger and more complex arbors (Pissadaki and Bolam 2013. SNc dopamine neurons may thus be classified into functionally distinct groups according to the size of their axonal arborisation. Furthermore, SNc dopamine neurons are divided into ventral tier neurons, which are more susceptible in PD and extend their dendrites in both SN pars reticulata (SNr and SNc, and dorsal tier neurons that restrict their dendrites within SNc. As SNr dendrites receive proportionally greater inhibitory input than SNc dendrites (Henny et al 2012, we examined the relationship between the dendritic compartmentalisation, synaptic input, burst generation and the extent of axonal arborisation. Because spatiotemporal interplay of synaptic stimulation has been

  20. Assessment of Storm Surge Forecasting Methods Used During Typhoon Haiyan

    Science.gov (United States)

    Mahar Francisco Lagmay, Alfredo; Malano, Vicente

    2014-05-01

    On 8 November 2013, Super Typhoon Haiyan made landfall in the central part of the Philippines. Considered one of the most powerful typhoons ever to make landfall in recorded history with 315 kph one-minute maximum sustained winds according to the Joint Typhoon Warning Center (JTWC), Haiyan brought widespread devastation in its path. Strong winds, heavy rainfall, and storm surges caused massive loss of lives and extensive damage to property. Storm surges were primarily responsible for the 6,201 dead, 1,785 missing and 28,626 injured in Haiyan's aftermath. This study documents the Haiyan storm surge simulations which were used as basis for the warnings provided to the public. The storm tide -- storm surge added to astronomical tide levels -- forecasts were made using the Japan Meteorological Agency's (JMA) Storm Surge Model and WXTide software. Storm surge maps for the entire Philippines and time series plots for observation points in areas along the path of the typhoon were produced. Storm tide heights between one and five meters were also predicted for 68 coastal areas two days prior to Haiyan's landfall. A storm surge inundation map showing the extent of coastal flooding for Tacloban City, Leyte, one of the most severely affected areas by the typhoon, was generated using FLO-2D software. This was validated using field data such as high water marks, eyewitness accounts from locals, and information from media coverage. This map can be used as reference to determine danger zones and safe evacuation sites during similar events. Typhoon Haiyan generated one of the biggest and most devastating storm surge events in several decades, exacting a high death toll despite its early prediction. Lessons learned from this calamity and information contained in this work may serve as useful reference to mitigate the heavy impact of future storm surge events in the Philippines and elsewhere.

  1. China's electric car surge

    International Nuclear Information System (INIS)

    Wang, Yunshi; Sperling, Daniel; Tal, Gil; Fang, Haifeng

    2017-01-01

    China's plug-in electric vehicle (PEV) sales, comprising both battery electric and plug-in hybrid vehicles, surged 343% in 2015, and are expected to reach 2 million by 2020. Two factors are crucial to this sudden transformation: 1) massive central and local government subsidies, and 2) huge non-monetary incentives via exemptions from restrictions on vehicle ownership in Beijing, Shanghai, and elsewhere. Innovative business models and greatly expanded vehicle offerings, especially by local Chinese manufacturers, also helped accelerate PEV sales and infrastructure deployment. However, continued sales growth is threatened by persistent regional protectionism, the unsustainability of these large subsidies, and widely reported cheating by some automakers. We suggest some innovative policies that China might pioneer and transfer elsewhere. - Highlights: • The rapid growth was a result of massive central and local government subsidies. • Exemptions from restrictions on vehicle ownership play even more important role. • A comparative case study of Beijing and Shanghai. • Persistent regional protectionism impedes the development of China's PEV industry. • Focusing on the use of PEVs is a better way to achieve eVMT.

  2. Pressure-surge mitigation methods in fluid-conveying piping

    International Nuclear Information System (INIS)

    Shin, Y.W.; Youngdahl, C.K.; Wiedermann, A.H.

    1991-01-01

    Pressure surges in the heat transport system of nuclear reactor plants can affect the safety and reliability of the plants. Hence the pressure surges must be considered in the design, operation, and maintenance of the plants in order to minimize their occurrence and impacts. The objectives of this paper are to review various methods to control or mitigate the pressure surges, to analyze these methods to gain understanding of the mitigation mechanisms, and examine applicability of the methods to nuclear power plants. 6 refs., 13 figs

  3. Storm surge model based on variational data assimilation method

    Directory of Open Access Journals (Sweden)

    Shi-li Huang

    2010-06-01

    Full Text Available By combining computation and observation information, the variational data assimilation method has the ability to eliminate errors caused by the uncertainty of parameters in practical forecasting. It was applied to a storm surge model based on unstructured grids with high spatial resolution meant for improving the forecasting accuracy of the storm surge. By controlling the wind stress drag coefficient, the variation-based model was developed and validated through data assimilation tests in an actual storm surge induced by a typhoon. In the data assimilation tests, the model accurately identified the wind stress drag coefficient and obtained results close to the true state. Then, the actual storm surge induced by Typhoon 0515 was forecast by the developed model, and the results demonstrate its efficiency in practical application.

  4. [Early morning hypertension/morning blood pressure surge].

    Science.gov (United States)

    Hoshide, Satoshi; Kario, Kazuomi

    2014-08-01

    Early morning hypertension and morning blood pressure surge have been reported to be associated with organ damage and cardiovascular events. The concept of early morning hypertension and morning blood pressure surge is sometimes discussed in the same arena, and provides partly overlapping information concerning their mechanism or risk profile. However, what is different between groups is as follows. First, early morning hypertension is blood pressure level, while morning blood pressure surge is variability of blood pressure. Second, the intervention of early morning hypertension is available, which lead to prevent the progression of organ damage or cardiovascular event, but there is not enough evidence whether the reduction of morning blood pressure surge would reduce cardiovascular outcome.

  5. Active surge control for variable speed axial compressors.

    Science.gov (United States)

    Lin, Shu; Yang, Chunjie; Wu, Ping; Song, Zhihuan

    2014-09-01

    This paper discusses active surge control in variable speed axial compressors. A compression system equipped with a variable area throttle is investigated. Based on a given compressor model, a fuzzy logic controller is designed for surge control and a proportional speed controller is used for speed control. The fuzzy controller uses measurements of the change of pressure rise as well as the change of mass flow to determine the throttle opening. The presented approach does not require the knowledge of system equilibrium or the surge line. Numerical simulations show promising results. The proposed fuzzy logic controller performs better than a backstepping controller and is capable to suppress surge at different operating points. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  6. Experimental Study on Noise Characteristic of Centrifugal Compressor Surge

    OpenAIRE

    Yang, Qichao; Zhao, Yuanyang; SHU, Yue; LI, Xiaosa; LI, Liansheng

    2016-01-01

    The centrifugal air compressor test rig is was designed and established. The experimental study was carried out on the surge characteristics of centrifugal compressor including the pressure in the pipe and the noise characteristics under different rotation speed. The tested results showed that both the suction pressure and discharge pressure fluctuation increase under surge condition and the amplitude of discharge pressure fluctuation is significantly higher than that of suction pressure. In ...

  7. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    neuro-trauma (28.7%) chronic subdural hematomas (22.8%) and spine and spinal cord diseases (21.2%) were ... mortality are infectious disease like tuberculosis, malaria and HIV /AIDS, neurosurgical conditions may not be .... Neuro-trauma, hydrocephalus, CSDH, spine & spinal cord diseases, and brain tumors were the ...

  8. Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Sackley, Catherine M; Smith, Christina H; Rick, Caroline; Brady, Marian C; Ives, Natalie; Patel, Ramilla; Roberts, Helen; Dowling, Francis; Jowett, Sue; Wheatley, Keith; Patel, Smitaa; Kelly, Debbie; Sands, Gina; Clarke, Carl

    2014-06-07

    Parkinson's disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems. Currently there is no preferred approach to speech and language therapy within the NHS and there is little evidence for the effectiveness of standard NHS therapy or Lee Silverman voice treatment. This trial aims to investigate the feasibility and acceptability of randomizing people with Parkinson's disease-related speech or voice problems to Lee Silverman voice treatment or standard speech and language therapy compared to a no-intervention control. The PD COMM pilot is a three arm, assessor-blinded, randomized controlled trial. Randomization will be computer-generated with participants randomized at a ratio of 1:1:1. Participants randomized to intervention arms will be immediately referred to the appropriate speech and language therapist. The target population are patients with a confirmed diagnosis of idiopathic Parkinson's disease who have problems with their speech or voice. The Lee Silverman voice treatment intervention group will receive the standard regime of 16 sessions between 50 and 60 minutes in length over four weeks, with extra home practice. The standard speech and language therapy intervention group will receive a dose determined by patients' individual needs, but not exceeding eight weeks of treatment. The control group will receive standard care with no speech and language therapy input for at least six months post-randomization. Outcomes will be assessed at baseline (pre-randomization) and post- randomization at three, six, and 12 months. The outcome measures include patient-reported voice measures, quality of life, resource use, and assessor-rated speech recordings. The recruitment aim is at least 60 participants over 21 months from 11 sites, equating to at least 20 participants in each arm of the trial. This trial is ongoing and recruitment commenced in May 2012. This study will

  9. Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: a potential target for anti-PD-1/PD-L1 therapy.

    Science.gov (United States)

    Roberts, Jordan A; Gonzalez, Raul S; Das, Satya; Berlin, Jordan; Shi, Chanjuan

    2017-12-01

    Poorly differentiated neuroendocrine carcinoma of the digestive system has a dismal prognosis with limited treatment options. This study aimed to investigate expression of the PD-1/PD-L1 pathway in these tumors. Thirty-seven patients with a poorly differentiated neuroendocrine carcinoma of the digestive system were identified. Their electronic medical records, pathology reports, and pathology slides were reviewed for demographics, clinical history, and pathologic features. Tumor sections were immunohistochemically labeled for PD-1 and PD-L1, and expression of PD-1 and PD-L1 on tumor and tumor-associated immune cells was analyzed and compared between small cell and large cell neuroendocrine carcinomas. The mean age of patients was 61 years old with 18 men and 19 women. The colorectum (n=20) was the most common primary site; other primary sites included the pancreaticobiliary system, esophagus, stomach, duodenum, and ampulla. Expression of PD-1 was detected on tumor cells (n=6, 16%) as well as on tumor-associated immune cells (n=23, 63%). The 6 cases with PD-1 expression on tumor cells also had the expression on immune cells. Expression of PD-L1 was visualized on tumor cells in 5 cases (14%) and on tumor-associated immune cells in 10 cases (27%). There was no difference in PD-1 and PD-L1 expression between small cell and large cell neuroendocrine carcinomas. In conclusion, PD-1/PD-L1 expression is a frequent occurrence in poorly differentiated neuroendocrine carcinomas of the digestive system. Checkpoint blockade targeting the PD-1/PD-L1 pathway may have a potential role in treating patients with this disease. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. iPS cells in the study of PD molecular pathogenesis.

    Science.gov (United States)

    Cobb, Melanie M; Ravisankar, Abinaya; Skibinski, Gaia; Finkbeiner, Steven

    2017-12-12

    Parkinson's disease (PD) is the second most common neurodegenerative disease and its pathogenic mechanisms are poorly understood. The majority of PD cases are sporadic but a number of genes are associated with familial PD. Sporadic and familial PD have many molecular and cellular features in common, suggesting some shared pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) have been derived from patients harboring a range of different mutations of PD-associated genes. PD patient-derived iPSCs have been differentiated into relevant cell types, in particular dopaminergic neurons and used as a model to study PD. In this review, we describe how iPSCs have been used to improve our understanding of the pathogenesis of PD. We describe what cellular and molecular phenotypes have been observed in neurons derived from iPSCs harboring known PD-associated mutations and what common pathways may be involved.

  11. Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk.

    Science.gov (United States)

    Nozhenko, Yuriy; Asnani-Kishnani, Madhu; Rodríguez, Ana M; Palou, Andreu

    2015-01-01

    A significant number of chronic diseases are linked to perinatal nutrition, and prevention may be associated to naturally occurring components of breast milk. One key hormone in breast milk is leptin, related with the protection from obesity in the adulthood, thus knowing its changes through the day or lactation is crucial. We aimed to investigate the daily rhythms in the milk levels of leptin, together with other two related hormones, ghrelin and adiponectin, during lactation (days 5, 10 and 15) in rat dams, and the relation with morphometric parameters (dams and pups). Summarizing the main results, the existence of biological rhythms, but not daily and maybe circasemidian, was confirmed for the three hormones at the earliest period of lactation. The correlations performed generally showed a possible dependence of milk hormone levels on plasma levels at the early phase of lactation, while with the progression of lactation this dependence may fade and the hormone levels are suggested to be more dependent on mammary gland production/maturation. There was also a correlation between milk leptin and adiponectin levels, especially in the first half of lactation, suggesting a possible parallel regulation. Interestingly, we describe a milk leptin surge around the mid of lactation (at day 10) which may be related with pup's growth (males and females) and with the well-known (in the literature) plasma leptin surge in pups. All this knowledge may be crucial for future applications in the development of formula milk and in relation with the role of leptin surge during lactation.

  12. G6PD-MutDB: a mutation and phenotype database of glucose-6-phosphate (G6PD) deficiency.

    Science.gov (United States)

    Zhao, Xin; Li, Zuofeng; Zhang, Xiaoyan

    2010-12-01

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzymatic disorder of red blood cells in humans due to mutations in the G6PD gene. The G6PD enzyme catalyzes the first step in the pentose phosphate pathway to protect cells against oxidative stress. Mutations in the G6PD gene will cause functional variants with various biochemical and clinical phenotypes. So far, about 160 mutations along with more than 400 biochemical variants have been described. G6PD-MutDB is a disease-specific resource of G6PD deficiency, collecting and integrating G6PD mutations with biochemical and clinical phenotypes. Data of G6PD deficiency is manually extracted from published papers, focusing primarily on variants with identified mutation and well-described quantitative phenotypes. G6PD-MutDB implements an approach, CNSHA predictor, to help identify a potential chronic non-spherocytic hemolytic anemia (CNSHA) phenotype of an unknown mutation. G6PD-MutDB is believed to facilitate analysis of relationship between molecular mutation and functional phenotype of G6PD deficiency owing to convenient data resource and useful tools. This database is available from http://202.120.189.88/mutdb.

  13. Methodology for surge pressure evaluation in a water injection system

    Energy Technology Data Exchange (ETDEWEB)

    Meliande, Patricia; Nascimento, Elson A. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Dept. de Engenharia Civil; Mascarenhas, Flavio C.B. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Hidraulica Computacional; Dandoulakis, Joao P. [SHELL of Brazil, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    Predicting transient effects, known as surge pressures, is of high importance for offshore industry. It involves detailed computer modeling that attempts to simulate the complex interaction between flow line and fluid in order to ensure efficient system integrity. Platform process operators normally raise concerns whether the water injection system is adequately designed or not to be protected against possible surge pressures during sudden valve closure. This report aims to evaluate the surge pressures in Bijupira and Salema water injection systems due to valve closure, through a computer model simulation. Comparisons among the results from empirical formulations are discussed and supplementary analysis for Salema system were performed in order to define the maximum volumetric flow rate for which the design pressure was able to withstand. Maximum surge pressure values of 287.76 bar and 318.58 bar, obtained in Salema and Bijupira respectively, using empirical formulations have surpassed the operating pressure design, while the computer model results have pointed the greatest surge pressure value of 282 bar in Salema system. (author)

  14. Surge recovery techniques for the Tevatron cold compressors

    International Nuclear Information System (INIS)

    Martinez, A.; Klebaner, A.L.; Makara, J.N.; Theilacker, J.C.; Fermilab

    2006-01-01

    The Fermilab Tevatron cryogenic system utilizes high-speed centrifugal cold compressors, made by Ishikawajima-Harima Heavy Industries Co. Ltd. (IHI), for high-energy operations [1]. The compressor is designed to pump 60 g/s of 3.6 K saturated helium vapor at a pressure ratio of 2.8, with an off-design range of 40 to 70 g/s and operating speeds between 40 and 95 krpm. Since initial commissioning in 1993, Tevatron transient conditions such as quench recovery have led to multiple-location machine trips as a result of the cold compressors entering the surge regime. Historically, compressors operating at lower inlet pressures and higher speeds have been especially susceptible to these machine trips and it was not uncommon to have multiple compressor trips during large multiple-house quenches. In order to cope with these events and limit accelerator down time, surge recovery techniques have been implemented in an attempt to prevent the compressors from tripping once the machine entered this surge regime. This paper discusses the different methods of surge recovery that have been employed. Data from tests performed at the Cryogenic Test Facility at Fermilab as well as actual Tevatron operational data were utilized. In order to aid in the determination of the surge region, a full mapping study was undertaken to characterize the entire pressure field of the cold compressor. These techniques were then implemented and tested at several locations in the Tevatron with some success

  15. Pain in Neurodegenerative Disease : Current Knowledge and Future Perspectives

    NARCIS (Netherlands)

    de Tommaso, Marina; Arendt-Nielsen, Lars; Defrin, Ruth; Kunz, Miriam; Pickering, Gisele; Valeriani, Massimiliano

    2016-01-01

    Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD),

  16. Targeting the PD-1/PD-L1 axis in the treatment of lung cancer

    Directory of Open Access Journals (Sweden)

    Matikas Alexios

    2016-03-01

    Full Text Available In recent years major advances in the field of molecular profiling of non-small cell lung cancer led to the identification of targetable driver mutations and revolutionized the treatment of specific patient subsets. However, the majority of NSCLC tumors do not harbor these genomic events. On the other hand, current studies have confirmed an expanding role for immunotherapy in lung cancer and new agents, such as inhibitors of the programmed cell death-1 (PD-1/programmed cell death ligand 1 (PD-L1 axis have been introduced in the treatment armamentarium. The monoclonal antibodies nivolumab and pembrolizumab targeting PD-1 resulted in superior survival when compared to standard second line chemotherapy within the context of randomized trials and received regulatory approval. Moreover, several other anti-PD-L1 antibodies have demonstrated encouraging preliminary efficacy and multiple clinical trials in various settings during the disease trajectory are currently underway. Early immunotherapy trials have also illustrated the potential of PD-1 blockade in small cell lung cancer treatment, a disease for which major advances in systemic therapy are lacking. The currently available clinical data on PD-1/PD-L1 inhibition in lung cancer are summarized in this review.

  17. Burden of Hemoglobinopathies (Thalassemia, Sickle Cell Disorders and G6PD Deficiency) in Iran, 1990-2010: findings from the Global Burden of Disease Study 2010.

    Science.gov (United States)

    Rezaei, Nazila; Naderimagham, Shohreh; Ghasemian, Anoosheh; Saeedi Moghaddam, Sahar; Gohari, Kimia; Zareiy, Saeid; Sobhani, Sahar; Modirian, Mitra; Kompani, Farzad

    2015-08-01

    Hemoglobinopathies are known as the most common genetic disorders in Iran. The paper aims to provide global estimates of deaths and disability adjusted life years (DALYs) due to hemoglobinopathies in Iran by sex and age during 1990 to 2010 and describe the challenges due to limitations of the Global Burden of Disease Study 2010 (GBD 2010). GBD 2010 estimates of the numbers of deaths and years of life lost (YLLs) due to premature mortality were calculated using the Cause of Death Ensemble model (CODEm). Years of life lost due to disability (YLDs) were computed by multiplication of prevalence, the disability weight for occurrence of sequelae, and the duration of symptoms. Prevalence was estimated through a systematic search of published and available unpublished data sources, with a Bayesian meta-regression model developed for GBD 2010. Disability weights were produced using collected data from population-based surveys. Uncertainty from all inputs was incorporated into the computations of DALYs using simulation methods. We aim to prepare and criticize the results of GBD 2010 and provide some recommendations for reaching better conclusions about the burden of hemoglobinopathies in Iran. Between 1990 and 2010, the overall deaths attributed to hemoglobinopathies decreased from 0.51% to 0.36% of total deaths, with the corresponding burden declining from 1% to 0.82% of total DALYs. There was a reduction in deaths and DALYs rates for all ages and the rates attributed to all ages followed the same pattern in Iranian men and women. The highest DALYs for hemoglobinopathies, thalassemia, sickle cell disorder, and glucose-6-phosphate dehydrogenase deficiency (G6PD-D) were found in those aged less than 5 years. The collective burden of all of these hemoglobin disorder was lower in 2010 than in 1990. Although the screening programs in Iran have been very successful in reducing the number of thalassemia patients between 1990 to 2010, in order to provide a better estimation of the

  18. G6pd

    Science.gov (United States)

    White, Karessa; Kim, Mi-Jung; Ding, Dalian; Han, Chul; Park, Hyo-Jin; Meneses, Zaimary; Tanokura, Masaru; Linser, Paul; Salvi, Richard; Someya, Shinichi

    2017-06-07

    Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP + to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems. We investigated the roles of G6PD in the cytosolic antioxidant defense in the cochlea of G6pd hypomorphic mice that were backcrossed onto normal-hearing CBA/CaJ mice. Young G6pd -deficient mice displayed a significant decrease in cytosolic G6PD protein levels and activities in the inner ears. However, G6pd deficiency did not affect the cytosolic NADPH redox state, or glutathione or thioredoxin antioxidant defense in the inner ears. No histological abnormalities or oxidative damage was observed in the cochlea of G6pd hemizygous males or homozygous females. Furthermore, G6pd deficiency did not affect auditory brainstem response hearing thresholds, wave I amplitudes or wave I latencies in young males or females. In contrast, G6pd deficiency resulted in increased activities and protein levels of cytosolic isocitrate dehydrogenase 1, an enzyme that catalyzes the conversion of isocitrate to α-ketoglutarate and NADP + to NADPH, in the inner ear. In a mouse inner ear cell line, knockdown of Idh1 , but not G6pd , decreased cell growth rates, cytosolic NADPH levels, and thioredoxin reductase activities. Therefore, under normal physiological conditions, G6pd deficiency does not affect the cytosolic glutathione or thioredoxin antioxidant defense in mouse cochlea. Under G6pd deficiency conditions, isocitrate dehydrogenase 1 likely functions as the principal source of NADPH for cytosolic antioxidant defense in the cochlea. SIGNIFICANCE STATEMENT Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP + to NADPH and

  19. Analysis of Acoustic Cavitation Surge in a Rocket Engine Turbopump

    Directory of Open Access Journals (Sweden)

    Hideaki Nanri

    2010-01-01

    Full Text Available In a liquid rocket engine, cavitation in an inducer of a turbopump sometimes causes instability phenomena when the inducer is operated at low inlet pressure. Cavitation surge (auto-oscillation, one such instability phenomenon, has been discussed mainly based on an inertia model assuming incompressible flow. When this model is used, the frequency of the cavitation surge decreases continuously as the inlet pressure of the turbopump decreases. However, we obtained an interesting experimental result in which the frequency of cavitation surge varied discontinuously. Therefore, we employed one-dimensional analysis based on an acoustic model in which the fluid is assumed to be compressible. The analytical result qualitatively corresponded with the experimental result.

  20. Electromagnetic computation methods for lightning surge protection studies

    CERN Document Server

    Baba, Yoshihiro

    2016-01-01

    This book is the first to consolidate current research and to examine the theories of electromagnetic computation methods in relation to lightning surge protection. The authors introduce and compare existing electromagnetic computation methods such as the method of moments (MOM), the partial element equivalent circuit (PEEC), the finite element method (FEM), the transmission-line modeling (TLM) method, and the finite-difference time-domain (FDTD) method. The application of FDTD method to lightning protection studies is a topic that has matured through many practical applications in the past decade, and the authors explain the derivation of Maxwell's equations required by the FDTD, and modeling of various electrical components needed in computing lightning electromagnetic fields and surges with the FDTD method. The book describes the application of FDTD method to current and emerging problems of lightning surge protection of continuously more complex installations, particularly in critical infrastructures of e...

  1. Storm surges in the Western Black Sea. Operational forecasting

    Directory of Open Access Journals (Sweden)

    G. MUNGOV

    2000-06-01

    Full Text Available The frequency of the storm surges in the Black Sea is lower than that in other regions of the World Ocean but they cause significant damages as the magnitude of the sea level set-up is up to 7-8 times greater than that of other sea level variations. New methods and systems for storm surge forecasting and studying their statistical characteristics are absolutely necessary for the purposes of the coastal zone management. The operational forecasting storm surge model of Meteo-France was adopted for the Black Sea in accordance with the bilateral agreement between Meteo-France and NINMH. The model was verified using tide-gauge observations for the strongest storms observed along the Bulgarian coast over the last 10 years.

  2. Investigation of surge protective devices operation of a wind generator

    International Nuclear Information System (INIS)

    Dimitrov, D.; Vasileva, M.

    2008-01-01

    The interest to the investments in a wind energetics increases in the last years. The wind energetics is the fastest developing direction in the energetics in global scale. The wind energy is more attractive because its prices are lower in comparison of the other technologies for generating energy. The right choice of the surge protective devices has the important meaning on building and exploitation of the wind generators. The aim of this paper is investigation of the surge protective devices operation when they are installation to a wind generator. (authors)

  3. G6PD Deficiency

    Science.gov (United States)

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that is most common in males. About 1 in 10 African American males in the United States has it. G6PD deficiency mainly affects red blood cells, which carry oxygen ...

  4. Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers.

    Science.gov (United States)

    Kim, Moon-Young; Koh, Jaemoon; Kim, Sehui; Go, Heounjeong; Jeon, Yoon Kyung; Chung, Doo Hyun

    2015-04-01

    Programmed cell death-1 (PD-1)/programmed cell death-ligand-1 (PD-L1) pathway-targeted immunotherapy has beneficial therapeutic effects in pulmonary squamous cell carcinoma (SqCC) patients. However, the expression patterns of PD-1 and PD-1 ligands (PD-Ls) in pulmonary SqCC remain unclear. Moreover, the association between the PD-1/PD-Ls pathway and the status of oncogenic drivers in pulmonary SqCC is unknown. PD-L1 and PD-L2 expression in tumor cells and the numbers of PD-1(+) and CD8(+) tumor-infiltrating lymphocytes (TILs) were examined in 331 resected SqCC tumors along with matched lymph node metastases from 77 cases using immunohistochemistry. EGFR and FGFR1 and MET expression and genetic status were also examined. PD-L1 and PD-L2 expression was detected in 26.9% and 23.9% of the pulmonary SqCC samples, respectively. PD-L1 and PD-L2 expression was maintained or increased in the metastatic lymph node tumors in 81.1% and 93.5% of the 77 cases, respectively. The numbers of PD-1(+) and CD8(+) TILs were significantly positively correlated (PL1 expression exhibited consistently high CD8(+) T cell infiltration (PL2 expression and increased PD-1(+) TILs (P=0.001 for both). Increased numbers of CD8(+) or PD-1(+) TILs were significantly associated with prolonged disease-free survival of these patients, whereas PD-L1 and PD-L2 expression had no significant prognostic implications. PD-L1 and PD-L2 expression in pulmonary SqCC is associated with an increased number of CD8(+) TILs and increased MET expression, which might provide therapeutic insight into targeting the PD-1/PD-Ls pathway in pulmonary SqCC. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    The various final histological diagnoses are presented in table 3. The most common histological diagnosis in this series was breast cancer [(336(53.2%)]. This was followed by fibroadenoma 150 (23.7%), and fibrocystic disease of the breast 92 [14.5%]. Using the final histological diagnoses as the standard, it would be noted ...

  6. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    Adinolfi MF, Hardin WD, O'Connell RC, et al: Amputations after vascular trauma in civilians. South Med ... body cavities (thorax and abdomen) require different approaches depending on the primary pathology ... Extensile exposures to the thoraco-lumbar spine is indicated in trauma, infection, degenerative disease, tumours ...

  7. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    neuro-trauma (28.7%) chronic subdural hematomas (22.8%) and spine and spinal cord diseases (21.2%) were the top adult neurosurgical patients. Ventriculo-peritoneal shunting. (32.2%), repair of neural tube defects (27.5%) and endoscopic third ventriculostomy were the three most common operative procedures for ...

  8. ISSN 2073 East Cent. Afr. j. surg.

    African Journals Online (AJOL)

    DELL

    2009-02-27

    Feb 27, 2009 ... grade, whilst 20(23.0%) had high-grade disease, 85.5% of bladder tumors were nonmuscle ... Sometimes blood clots may form and cause pain or ... Genitourinary sonography and uretherocystoscopic examination of the bladder were the main modalities of investigation in the diagnosis of bladder tumors, ...

  9. Do subjects with minimal motor features have prodromal PD?

    Science.gov (United States)

    Chu, Yaping; Buchman, Aron S; Olanow, C W; Kordower, Jeffrey H

    2018-02-08

    Understanding the pathological changes underlying mild motor features of the eldery and defining a patient population with prodromal Parkinson's disease (PD) are of great clinical importance. It remains unclear, however, how to accurately and specifically diagnose prodromal PD. We examined whether older adults with minimal parkinsonian motor features have nigrostriatal degeneration and α-synuclein pathology consistent with prodromal PD. Brain sections were obtained from older adults with a clinical diagnosis of PD (N=21) and without a clinical diagnosis of PD (N=27) who underwent motor examination proximate to death. Cases without PD were further dichotomized into no motor deficit (n=9) or minimal motor features (n-18) groups using a modified Unified Parkinson's Disease Rating Scale. We performed quantitative unbiased stereological analyses of dopaminergic neurons/terminals and α-synuclein accumulation in the nigrostriatal system. In all subjects with minimal motor features, there were significant reductions in dopaminergic neurons and terminals in the substantia nigra and putamen that was intermediate between subjects with no motor deficit and PD. Phosphorylated α-synuclein inclusions were observed in the substantia nigra that were of similar density to what was seen in PD. Furthermore, there was greater Lewy neuritic pathology in the putamen relative to PD patients. Lastly, neurons with α-synuclein inclusions displayed reductions in tyrosine hydroxylase expression that was comparable in subjects with both minimal motor features and PD. Minimal motor features in older adults may represent prodromal PD and identify at risk individuals for testing putative neuroprotective interventions that could slow or prevent PD progression. This article is protected by copyright. All rights reserved. © 2018 American Neurological Association.

  10. Acoustic Analysis of PD Speech

    Directory of Open Access Journals (Sweden)

    Karen Chenausky

    2011-01-01

    Full Text Available According to the U.S. National Institutes of Health, approximately 500,000 Americans have Parkinson's disease (PD, with roughly another 50,000 receiving new diagnoses each year. 70%–90% of these people also have the hypokinetic dysarthria associated with PD. Deep brain stimulation (DBS substantially relieves motor symptoms in advanced-stage patients for whom medication produces disabling dyskinesias. This study investigated speech changes as a result of DBS settings chosen to maximize motor performance. The speech of 10 PD patients and 12 normal controls was analyzed for syllable rate and variability, syllable length patterning, vowel fraction, voice-onset time variability, and spirantization. These were normalized by the controls' standard deviation to represent distance from normal and combined into a composite measure. Results show that DBS settings relieving motor symptoms can improve speech, making it up to three standard deviations closer to normal. However, the clinically motivated settings evaluated here show greater capacity to impair, rather than improve, speech. A feedback device developed from these findings could be useful to clinicians adjusting DBS parameters, as a means for ensuring they do not unwittingly choose DBS settings which impair patients' communication.

  11. Corticomuscular coherence during hand gripping with DBS and medication in PD patients

    DEFF Research Database (Denmark)

    Sridharan, Kousik Sarathy; Højlund, Andreas; Johnsen, Erik Lisbjerg

    Deep brain stimulation (DBS) effectively alleviates the motor symptoms in Parkinson’s disease (PD) although its effect mechanism is still unclear. CMC is reduced in PD patients but restorable with medication, while DBS variably affects CMC in advanced PD patients. We recorded magnetoencephalography...

  12. A Surge of Interest in Uganda's Art Deco | Craddock Williams ...

    African Journals Online (AJOL)

    A Surge of Interest in Uganda's Art Deco. Vivian Craddock Williams. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/uj.v46i1.23038 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  13. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    Koura A, Ogouyemi A, Hounnou GM, Agoussou Voyeme A, Goudote E. Les hernies ombilicales étranglées chez lsenfant au cNHU de cotonou : A propos de 111 cas. Med Afr Noire 1996; 43: 638. 41. 12. Keshtgar AS, Griffiths M. Incarceration of umbilical hernia in children: Is the trend increasing? Eur J PediatrSurg 2003; 13: ...

  14. Into the Surge of Network-driven Innovation

    DEFF Research Database (Denmark)

    Østergaard, Claus Møller; Rosenstand, Claus Andreas Foss; Gertsen, Frank

    2013-01-01

    this is examined from the 1880’s up until today. The contribution of the paper is a societal perspective on innovation, where the difference between industrial society and knowledge society leads into the surge of network-driven innovation. Network-driven innovation is unfolded on top of the known cost- driven...

  15. Study of surge current effects on solid tantalum capacitors

    Science.gov (United States)

    1980-01-01

    Results are presented of a 2,000 hour cycled life test program conducted to determine the effect of short term surge current screening on approximately 47 micron f/volt solid tantalum capacitors. The format provides average values and standard deviations of the parameters, capacitance, dissipation factor, and equivalent series resistance at 120 Hz, 1KHz, abd 40 KHz.

  16. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    148. ISSN 2073-9990 East Cent. Afr. J. surg. COSECSA/ASEA Publication -East & Central African Journal of Surgery. March/April 2016 Volume 21 (1). Urological injuries following Obstetricaland Gynecological Surgeries. H.R. Sebukoto¹, E. Semwaga², R.A. Rugakingila³. 1Kilimanjaro Christian Medical University College.

  17. 14 CFR 33.65 - Surge and stall characteristics.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Surge and stall characteristics. 33.65 Section 33.65 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... stall characteristics. When the engine is operated in accordance with operating instructions required by...

  18. Aging assessment of surge protective devices in nuclear power plants

    International Nuclear Information System (INIS)

    Davis, J.F.; Subudhi, M.; Carroll, D.P.

    1996-01-01

    An assessment was performed to determine the effects of aging on the performance and availability of surge protective devices (SPDs), used in electrical power and control systems in nuclear power plants. Although SPDs have not been classified as safety-related, they are risk-important because they can minimize the initiating event frequencies associated with loss of offsite power and reactor trips. Conversely, their failure due to age might cause some of those initiating events, e.g., through short circuit failure modes, or by allowing deterioration of the safety-related component(s) they are protecting from overvoltages, perhaps preventing a reactor trip, from an open circuit failure mode. From the data evaluated during 1980--1994, it was found that failures of surge arresters and suppressers by short circuits were neither a significant risk nor safety concern, and there were no failures of surge suppressers preventing a reactor trip. Simulations, using the ElectroMagnetic Transients Program (EMTP) were performed to determine the adequacy of high voltage surge arresters

  19. ISSN 2073-9990 East Cent Afr J Surg

    African Journals Online (AJOL)

    ISSN 2073-9990 East Cent Afr J Surg. 57 COSECSA/ASEA Publication -- East & Central African Journal of Surgery 2017; Vol. ... period at a trauma centre in Nigeria. Methods: This was a retrospective review of in-hospital trauma deaths during the period of ..... haematoma evacuation. Four patients underwent laparotomy for ...

  20. Multidimensional Numerical Modeling of Surges Over Initially Dry Land

    National Research Council Canada - National Science Library

    Berger, R

    2004-01-01

    .... The first test case is for a straight flume and the second contains a reservoir and a horseshoe channel section. It is important that the model match the timing of the surge as well as the height In both cases the ADH compared closely with the flume results.

  1. Aging assessment of surge protective devices in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Davis, J.F.; Subudhi, M. [Brookhaven National Lab., Upton, NY (United States); Carroll, D.P. [Florida Univ., Gainesville, FL (United States)

    1996-01-01

    An assessment was performed to determine the effects of aging on the performance and availability of surge protective devices (SPDs), used in electrical power and control systems in nuclear power plants. Although SPDs have not been classified as safety-related, they are risk-important because they can minimize the initiating event frequencies associated with loss of offsite power and reactor trips. Conversely, their failure due to age might cause some of those initiating events, e.g., through short circuit failure modes, or by allowing deterioration of the safety-related component(s) they are protecting from overvoltages, perhaps preventing a reactor trip, from an open circuit failure mode. From the data evaluated during 1980--1994, it was found that failures of surge arresters and suppressers by short circuits were neither a significant risk nor safety concern, and there were no failures of surge suppressers preventing a reactor trip. Simulations, using the ElectroMagnetic Transients Program (EMTP) were performed to determine the adequacy of high voltage surge arresters.

  2. A novel parameter estimation method for metal oxide surge arrester ...

    Indian Academy of Sciences (India)

    Accurate modelling and exact determination of Metal Oxide (MO) surge arrester parameters are very important for arrester allocation, insulation coordination studies and systems reliability calculations. In this paper, a new technique, which is the combination of Adaptive Particle Swarm Optimization (APSO) and Ant Colony ...

  3. Tide Gauge and Satellite Altimetry Integration for Storm Surge Prediction

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Cheng, Yongcun; Deng, X.

    2013-01-01

    Integrating coarse temporal sampling by the satellite altimeter in the deep ocean with the high temporal sampling at tide gauges in sparse location along the coast has been used to improve the forecast of high water in the North Sea along the Danish Coast and storm surges along the Northeast coas...

  4. Increasing the highest storm surge in Busan harbor

    Science.gov (United States)

    Oh, Sang Myeong; Moon, Il-Ju; Kwon, Suk Jae

    2017-04-01

    One of the most pronounced effects of climate change in coastal regions is sea level rise and storm surges. Busan in particular, the fifth largest container handling port in the world, has suffered from serious storm surges and experienced a remarkable mean sea level (MSL) rise. This study investigates a long-term variation of annual maximum surge height (AMSH) using sea level data observed in Busan over 53 years (1962 2014). The decomposition of astronomical tides and surge components shows that the AMSH has increased 18 cm over 53 years (i.e., 3.5 mm/year), which is much larger than the MSL trend (2.5 mm/year) in Busan. This significant increase in AMSH is mostly explained by the increased intensity of landfall typhoons over the Korean peninsula (KP), which is associated with the increase of sea surface temperature and the decrease of vertical wind shear at mid-latitudes of the western North Pacific. In a projected future warming environment, the combination of an increasing MSL and AMSH will accelerate the occurrence of record-breaking extreme sea levels, which will be a potential threat in Busan harbor.

  5. Model simulation of storm surge potential for Andaman islands

    Digital Repository Service at National Institute of Oceanography (India)

    Kumar, V.S.; RameshBabu, V.; Babu, M.T.; Dhinakaran, G.; Rajamanickam, G.V.

    The Andaman Islands face the surge disaster threat as their north-south orientation comes across the eastward path of severe cyclones moving from the Andaman sea known for the genesis of many severe cyclones that traverse the Bay of Bengal regularly...

  6. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    Afr. J. surg. COSECSA/ASEA Publication - East and Central African Journal of Surgery. December 2016; Vol. 21 No. 3. The Surgical Management of Primary Hyperparathyroidism: The Experience in Tikur nbessa. Specialized Tertiary Referral and Teaching Hospital, ddis baba, Ethiopia. Sahilu Wondimu1, Berhanu Nega2.

  7. Surge of plasma waves in an inhomogeneous plasma

    International Nuclear Information System (INIS)

    Benhassine, Mohammed

    1985-01-01

    The first part of this research thesis addresses the propagation of waves in a plasma. It presents the equation of propagation of an electromagnetic wave in a plasma without magnetic field, and analyses the propagation in an inhomogeneous medium. The second part addresses the wave-particle interaction: interaction between electrons and an electromagnetic wave, between electrons and an electrostatic wave (trapping), and between electrons and a localised electric field. The third chapter presents the analytic theory of oscillations of a cold plasma (macroscopic equations in Lagrangian coordinates, analytic solution before surge). The next chapter discusses physical interpretations before the wave surge, after the wave surge, and about energy exchange (within or outside of resonance). Numerical simulations and their results are then reported and discussed. The sixth chapter addresses the case of an electrostatic wave surge in a hot plasma. It notably addresses the following aspects: equivalence between the description of moments and the Waterbag model, interaction between non linearity and thermal effects, variation of electric field amplitude with temperature. Results of numerical simulations are presented, and the last part addresses experimental predictions for microwaves-plasma interaction and laser-matter interaction [fr

  8. Disease-modifying influences of coexistent G6PD-deficiency, Gilbert syndrome and deletional alpha thalassemia in hereditary spherocytosis: A report of three cases.

    Science.gov (United States)

    Jamwal, Manu; Aggarwal, Anu; Kumar, Verinder; Sharma, Prashant; Sachdeva, Man Updesh Singh; Bansal, Deepak; Malhotra, Pankaj; Das, Reena

    2016-07-01

    Hereditary spherocytosis (HS) is a common inherited hemolytic anemia characterized by heterogeneous clinical presentations with variable degrees of anemia, jaundice, splenomegaly and gallstones. Although the underlying genetic defects in red cell membrane proteins may explain many phenotypic variations, a proportion of variability may be due to other co-inherited factors like enzymopathies, thalassemias and Gilbert syndrome. Associations of HS with glucose-6-phosphate dehydrogenase (G6PD) deficiency and Gilbert syndrome in isolation have been reported previously. We describe 3 adult cases of HS with concomitant Gilbert syndrome and G6PD-Mediterranean mutations (2 hemizygous males, aged 15 and 35y and 1 heterozygous 25-y female). Two patients required multiple transfusions that required splenectomy for management. One patient (15y male) also carried the single gene alpha 4.2 deletion and was less symptomatic. These cases illustrate the importance of clinico-pathological correlation and judicious extended testing for various contributing factors that may modify the clinical course of HS patients. G6PD deficiency is also a common enzymopathy in India and can contribute to the phenotypic heterogeneity. Its recognition is important for advising avoidance of oxidizing drug exposure. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor.

    Science.gov (United States)

    Peled, Michael; Tocheva, Anna S; Sandigursky, Sabina; Nayak, Shruti; Philips, Elliot A; Nichols, Kim E; Strazza, Marianne; Azoulay-Alfaguter, Inbar; Askenazi, Manor; Neel, Benjamin G; Pelzek, Adam J; Ueberheide, Beatrix; Mor, Adam

    2018-01-16

    Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications. Nevertheless, a significant proportion of patients do not respond to anti-PD-1 treatment, and a better understanding of the signaling pathways downstream of PD-1 could provide biomarkers for those whose tumors respond and new therapeutic approaches for those whose tumors do not. We used affinity purification mass spectrometry to uncover multiple proteins associated with PD-1. Among these proteins, signaling lymphocytic activation molecule-associated protein (SAP) was functionally and mechanistically analyzed for its contribution to PD-1 inhibitory responses. Silencing of SAP augmented and overexpression blocked PD-1 function. T cells from patients with X-linked lymphoproliferative disease (XLP), who lack functional SAP, were hyperresponsive to PD-1 signaling, confirming its inhibitory role downstream of PD-1. Strikingly, signaling downstream of PD-1 in purified T cell subsets did not correlate with PD-1 surface expression but was inversely correlated with intracellular SAP levels. Mechanistically, SAP opposed PD-1 function by acting as a molecular shield of key tyrosine residues that are targets for the tyrosine phosphatase SHP2, which mediates PD-1 inhibitory properties. Our results identify SAP as an inhibitor of PD-1 function and SHP2 as a potential therapeutic target in patients with XLP.

  10. Why does substorm-associated auroral surge travel westward?

    Science.gov (United States)

    Ebihara, Y.; Tanaka, T.

    2018-01-01

    A substorm is a long-standing unsolved issue in solar-terrestrial physics. One of the big challenges is to explain reasonably the evolution of the morphological structure of the aurora associated with the substorm. The sudden appearance of a bright aurora and an auroral surge traveling westward (westward traveling surge, WTS) are noticeable features of the aurora during the substorm expansion phase. By using a global magnetohydrodynamics (MHD) simulation, we obtained the following results regarding the WTS. When the interplanetary magnetic field turns southward, a persistent dynamo appears in the cusp/mantle region, driving the two-cell magnetospheric convection. Then, the substorm growth phase begins. When magnetic reconnection takes place in the magnetotail, plasma is accelerated earthward in the plasma sheet, and accelerated toward the equatorial plane in the lobe. The second dynamo appears in the near-Earth region, which is closely associated with the generation of the field-aligned current (FAC) on the nightside. When the FAC reaches the ionosphere, the aurora becomes bright, and the onset of the expansion phase begins. In the ionosphere, the conductivity is intensified in the bright aurora due to the precipitation of accelerated electrons. The conductivity gradient gives rise to the overflow of the Hall current, which acts as the third dynamo. The overflow results in the accumulation of space charge, which causes a divergent electric field. The divergent electric field generates a thin, structured upward FAC adjacent to the bright aurora. The opposite process takes place on the opposite side of the bright aurora. In short, the upward FAC increases (appearance of aurora) at the leading edge of the surge, and decreases (disappearance of aurora) at the trailing edge of the surge. By repeating these processes, the surge seems to travel westward.

  11. Assessment of water pipes durability under pressure surge

    Science.gov (United States)

    Pham Ha, Hai; Minh, Lanh Pham Thi; Tang Van, Lam; Bulgakov, Boris; Bazhenova, Soafia

    2017-10-01

    Surge phenomenon occurs on the pipeline by the closing valve or pump suddenly lost power. Due to the complexity of the water hammer simulation, previous researches have only considered water hammer on the single pipe or calculation of some positions on water pipe network, it have not been analysis for all of pipe on the water distribution systems. Simulation of water hammer due to closing valve on water distribution system and the influence level of pressure surge is evaluated at the defects on pipe. Water hammer on water supply pipe network are simulated by Water HAMMER software academic version and the capacity of defects are calculated by SINTAP. SINTAP developed from Brite-Euram projects in Brussels-Belgium with the aim to develop a process for assessing the integrity of the structure for the European industry. Based on the principle of mechanical fault, indicating the size of defects in materials affect the load capacity of the product in the course of work, the process has proposed setting up the diagram to fatigue assessment defect (FAD). The methods are applied for water pipe networks of Lien Chieu district, Da Nang city, Viet Nam, the results show the affected area of wave pressure by closing the valve and thereby assess the greatest pressure surge effect to corroded pipe. The SINTAP standard and finite element mesh analysis at the defect during the occurrence of pressure surge which will accurately assess the bearing capacity of the old pipes. This is one of the bases to predict the leakage locations on the water distribution systems. Amount of water hammer when identified on the water supply networks are decreasing due to local losses at the nodes as well as the friction with pipe wall, so this paper adequately simulate water hammer phenomena applying for actual water distribution systems. The research verified that pipe wall with defect is damaged under the pressure surge value.

  12. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... In Your Area Resources & Support PD Library Legal, Financial, & Insurance Matters Blog For Caregivers Living with Parkinson's ... Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners ...

  13. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... on Excessive Daytime Sleepiness? What Are the Common Sleep Disorders Encountered in Patients with PD? What Treatments Exist ...

  14. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... and Scheduling: Part 2 What Are the Common Sleep Disorders Encountered in Patients with PD? How Is Parkinson's ...

  15. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: Webinars: Nursing Solutions: Recognizing the ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in ...

  16. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: ... Therapeutic Approaches for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 What Is the Progression ...

  17. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... and Scheduling: Part 2 What Are the Common Sleep Disorders Encountered in Patients with PD? What Type of ...

  18. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert ... Parkinson's Disease Dealing with Dementia CareMAP: Life Beyond This Life What Are Some Tips for Following a ...

  19. Parkinson's Disease Videos

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    Full Text Available ... Soy el compas de otra canción” Expert Briefings: Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal ...

  20. Parkinson's Disease Videos

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    Full Text Available ... Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nursing Solutions: Recognizing the Impact of ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in ...

  1. Parkinson's Disease Videos

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    Full Text Available ... for PD Patients? Are There Any Ways to Control the Rate of Progression of the Disease? Walking ... Couric What Are Some Strategies to Improve the Quality of Community Care for PD Patients? CareMAP: Bathroom: ...

  2. Parkinson's Disease Videos

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    Full Text Available ... Shop A A You are here Home PD Library Search library Topic Type Expert Briefings: Parkinson's Disease Psychosis: Hallucinations, ... Help is just a click away. The PD Library is an extensive collection of books, fact sheets, ...

  3. Parkinson's Disease Videos

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    Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... and Scheduling: Part 2 What Are the Common Sleep Disorders Encountered in Patients with PD? Overview of Parkinson's ...

  4. Parkinson's Disease Videos

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    Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... and Scheduling: Part 2 What Are the Common Sleep Disorders Encountered in Patients with PD? Ask the Helpline: ...

  5. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nursing Solutions: Innovations in PD Nurse Education CareMAP: Managing Advanced Parkinson's Website CareMAP: El Descanso ...

  6. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's In Your Area Resources & Support PD Library Legal, Financial, & Insurance Matters Blog For Caregivers Living with ... Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nursing ...

  7. Parkinson's Disease Videos

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    Full Text Available ... for PD Patients? Are There Any Ways to Control the Rate of Progression of the Disease? OHSU - ... Couric What Are Some Strategies to Improve the Quality of Community Care for PD Patients? CareMAP: Bathroom: ...

  8. Parkinson's Disease Videos

    Science.gov (United States)

    ... PD: What You Need to Know Expert Briefings: Cognition and PD: What You've Always Wanted to ... People with Parkinson's? How Does Parkinson's Disease Affect Memory? When and What Type of Treatment Is Initiated ...

  9. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... PD: What You Need to Know Expert Briefings: Cognition and PD: What You've Always Wanted to ... People with Parkinson's? How Does Parkinson's Disease Affect Memory? When and What Type of Treatment Is Initiated ...

  10. Validating the calculated reliability and availability in Dutch storm surge barriers (and other infrastructural works)

    NARCIS (Netherlands)

    Kleijn van Willigen, G.K.; Meerveld, H. van

    2016-01-01

    The reliability and availability of the Dutch storm surge barriers are calculated by probabilistic risk assessment and various underlying risk analysis methods. These calculations, however, focus on the numerical probability of the storm surge barrier functioning adequately, and the implementation

  11. Observing storm surges in the Bay of Bengal from satellite altimetry

    Digital Repository Service at National Institute of Oceanography (India)

    Antony, C.; Testut, L.; Unnikrishnan, A.S.

    . As the repeat period of the orbit is the key factor to increase the probability of observing surges by a satellite, a high repetitive constellation of altimeter satellites can considerably enhance the chances of capturing of surge signals. Classical altimeters...

  12. Nonmotor symptoms in genetic Parkinson disease

    DEFF Research Database (Denmark)

    Kasten, Meike; Kertelge, Lena; Brüggemann, Norbert

    2010-01-01

    To review current knowledge on nonmotor symptoms (NMS), particularly psychiatric features, in genetic Parkinson disease (PD) and to provide original data for genetic and idiopathic PD.......To review current knowledge on nonmotor symptoms (NMS), particularly psychiatric features, in genetic Parkinson disease (PD) and to provide original data for genetic and idiopathic PD....

  13. Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk.

    Directory of Open Access Journals (Sweden)

    Yuriy Nozhenko

    Full Text Available A significant number of chronic diseases are linked to perinatal nutrition, and prevention may be associated to naturally occurring components of breast milk. One key hormone in breast milk is leptin, related with the protection from obesity in the adulthood, thus knowing its changes through the day or lactation is crucial. We aimed to investigate the daily rhythms in the milk levels of leptin, together with other two related hormones, ghrelin and adiponectin, during lactation (days 5, 10 and 15 in rat dams, and the relation with morphometric parameters (dams and pups. Summarizing the main results, the existence of biological rhythms, but not daily and maybe circasemidian, was confirmed for the three hormones at the earliest period of lactation. The correlations performed generally showed a possible dependence of milk hormone levels on plasma levels at the early phase of lactation, while with the progression of lactation this dependence may fade and the hormone levels are suggested to be more dependent on mammary gland production/maturation. There was also a correlation between milk leptin and adiponectin levels, especially in the first half of lactation, suggesting a possible parallel regulation. Interestingly, we describe a milk leptin surge around the mid of lactation (at day 10 which may be related with pup's growth (males and females and with the well-known (in the literature plasma leptin surge in pups. All this knowledge may be crucial for future applications in the development of formula milk and in relation with the role of leptin surge during lactation.

  14. Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade

    Directory of Open Access Journals (Sweden)

    Ikebuchi Ryoyo

    2011-09-01

    Full Text Available Abstract The inhibitory receptor programmed death-1 (PD-1 and its ligand, programmed death-ligand 1 (PD-L1 are involved in immune evasion mechanisms for several pathogens causing chronic infections. Blockade of the PD-1/PD-L1 pathway restores anti-virus immune responses, with concomitant reduction in viral load. In a previous report, we showed that, in bovine leukemia virus (BLV infection, the expression of bovine PD-1 is closely associated with disease progression. However, the functions of bovine PD-L1 are still unknown. To investigate the role of PD-L1 in BLV infection, we identified the bovine PD-L1 gene, and examined PD-L1 expression in BLV-infected cattle in comparison with uninfected cattle. The deduced amino acid sequence of bovine PD-L1 shows high homology to the human and mouse PD-L1. The proportion of PD-L1 positive cells, especially among B cells, was upregulated in cattle with the late stage of the disease compared to cattle at the aleukemic infection stage or uninfected cattle. The proportion of PD-L1 positive cells correlated positively with prediction markers for the progression of the disease such as leukocyte number, virus load and virus titer whilst on the contrary, it inversely correlated with the degree of interferon-gamma expression. Blockade of the PD-1/PD-L1 pathway in vitro by PD-L1-specific antibody upregulated the production of interleukin-2 and interferon-gamma, and correspondingly, downregulated the BLV provirus load and the proportion of BLV-gp51 expressing cells. These data suggest that PD-L1 induces immunoinhibition in disease progressed cattle during chronic BLV infection. Therefore, PD-L1 would be a potential target for developing immunotherapies against BLV infection.

  15. Parkinson's Disease

    Science.gov (United States)

    Parkinson's disease (PD) is a type of movement disorder. It happens when nerve cells in the brain don't ... coordination As symptoms get worse, people with the disease may have trouble walking, talking, or doing simple ...

  16. Effect of layout on surge line thermal stratification

    International Nuclear Information System (INIS)

    Lai Jianyong; Huang Wei

    2011-01-01

    In order to analyze and evaluate the effect of layout on the thermal stratification for PWR Pressurizer surge line, numerical simulation by Computational Fluid Dynamics (CFD) method is taken on 6 kinds of layout improvement with 2 improvement schemes, i.e., increasing the obliquity of quasi horizontal section and adding a vertical pipe between the quasi horizontal section and next elbow, and the maximum temperature differences of quasi horizontal section of surge line of various layouts under different flowrate are obtained. The comparison shows that, the increasing of the obliquity of quasi horizontal section can mitigate the thermal stratification phenomena but can not eliminate this phenomena, while the adding of a vertical pipe between the quasi horizontal section and next elbow can effectively mitigate and eliminate the thermal stratification phenomena. (authors)

  17. Electric Field Simulation of Surge Capacitors with Typical Defects

    Science.gov (United States)

    Zhang, Chenmeng; Mao, Yuxiang; Xie, Shijun; Zhang, Yu

    2018-03-01

    The electric field of power capacitors with different typical defects in DC working condition and impulse oscillation working condition is studied in this paper. According to the type and location of defects and considering the influence of space charge, two-dimensional models of surge capacitors with different typical defects are simulated based on ANSYS. The distribution of the electric field inside the capacitor is analyzed, and the concentration of electric field and its influence on the insulation performance are obtained. The results show that the type of defects, the location of defects and the space charge all affect the electric field distribution inside the capacitor in varying degrees. Especially the electric field distortion in the local area such as sharp corners and burrs is relatively larger, which increases the probability of partial discharge inside the surge capacitor.

  18. Pressurizer with a mechanically attached surge nozzle thermal sleeve

    Energy Technology Data Exchange (ETDEWEB)

    Wepfer, Robert M

    2014-03-25

    A thermal sleeve is mechanically attached to the bore of a surge nozzle of a pressurizer for the primary circuit of a pressurized water reactor steam generating system. The thermal sleeve is attached with a series of keys and slots which maintain the thermal sleeve centered in the nozzle while permitting thermal growth and restricting flow between the sleeve and the interior wall of the nozzle.

  19. High voltage measurements on metal-oxide surge arresters

    Energy Technology Data Exchange (ETDEWEB)

    Yli-Aeyhoe, S. [Tampere University of Technology (Finland). High Voltage Laboratory

    2000-07-01

    Metal-oxide surge arresters (MOA) are used to prevent damages caused by overvoltages and currents. Because of the function of MOAs they have to be tested with high voltage and with high current. The aim of this seminar paper is to give some information how MOAs can be tested in laboratory circumstances and on- site. Few new test methods are introduced as well. (orig.)

  20. Hypothalamic control of the male neonatal testosterone surge.

    Science.gov (United States)

    Clarkson, Jenny; Herbison, Allan E

    2016-02-19

    Sex differences in brain neuroanatomy and neurophysiology underpin considerable physiological and behavioural differences between females and males. Sexual differentiation of the brain is regulated by testosterone secreted by the testes predominantly during embryogenesis in humans and the neonatal period in rodents. Despite huge advances in understanding how testosterone, and its metabolite oestradiol, sexually differentiate the brain, little is known about the mechanism that actually generates the male-specific neonatal testosterone surge. This review examines the evidence for the role of the hypothalamus, and particularly the gonadotropin-releasing hormone (GnRH) neurons, in generating the neonatal testosterone surge in rodents and primates. Kisspeptin-GPR54 signalling is well established as a potent and critical regulator of GnRH neuron activity during puberty and adulthood, and we argue here for an equally important role at birth in driving the male-specific neonatal testosterone surge in rodents. The presence of a male-specific population of preoptic area kisspeptin neurons that appear transiently in the perinatal period provide one possible source of kisspeptin drive to neonatal GnRH neurons in the mouse. © 2016 The Author(s).

  1. Hypothalamic control of the male neonatal testosterone surge

    Science.gov (United States)

    Clarkson, Jenny; Herbison, Allan E.

    2016-01-01

    Sex differences in brain neuroanatomy and neurophysiology underpin considerable physiological and behavioural differences between females and males. Sexual differentiation of the brain is regulated by testosterone secreted by the testes predominantly during embryogenesis in humans and the neonatal period in rodents. Despite huge advances in understanding how testosterone, and its metabolite oestradiol, sexually differentiate the brain, little is known about the mechanism that actually generates the male-specific neonatal testosterone surge. This review examines the evidence for the role of the hypothalamus, and particularly the gonadotropin-releasing hormone (GnRH) neurons, in generating the neonatal testosterone surge in rodents and primates. Kisspeptin–GPR54 signalling is well established as a potent and critical regulator of GnRH neuron activity during puberty and adulthood, and we argue here for an equally important role at birth in driving the male-specific neonatal testosterone surge in rodents. The presence of a male-specific population of preoptic area kisspeptin neurons that appear transiently in the perinatal period provide one possible source of kisspeptin drive to neonatal GnRH neurons in the mouse. PMID:26833836

  2. Hospitals Capability in Response to Disasters Considering Surge Capacity Approach

    Directory of Open Access Journals (Sweden)

    Gholamreza Khademipour

    2016-01-01

    Full Text Available Background: The man-made and natural disasters have adverse effects with sound, apparent, and unknown consequences. Among various components of disaster management in health sector, the most important role is performed by health-treatment systems, especially hospitals. Therefore, the present study aimed to evaluate the surge capacity of hospitals of Kerman Province in disaster in 2015. Materials and Methods: This is a quantitative study, conducted on private, military, and medical sciences hospitals of Kerman Province. The sampling method was total count and data collection for the research was done by questionnaire. The first section of the questionnaire included demographic information of the studied hospitals and second part examined the hospital capacity in response to disasters in 4 fields of equipment, physical space, human resources, and applied programs. The extracted data were analyzed by descriptive statistics. Results: The mean capability of implementing the surge capacity programs by hospitals of Kerman Province in disasters and in 4 fields of equipment, physical space, human resources, and applied programs was evaluated as 7.33% (weak. The surge capacity capability of state hospitals in disasters was computed as 8% and compared to private hospitals (6.07% had a more suitable condition. Conclusion: Based on the results of study and significance of preparedness of hospitals in response to disasters, it is proposed that managers of studied hospitals take measures to promote the hospital response capacity to disasters based on 4 components of increasing hospital capacity.

  3. Quantification of Sediment Transport During Glacier Surges and its Impact on Landform Architecture

    DEFF Research Database (Denmark)

    Kjær, Kurt H.; Schomacker, Anders; Korsgaard, Niels Jákup

    ) for 1945, prior to the last surge in 1964, and for 2003 in order to assess the effect of the surge on the sediment architecture in the forefield. The pre- and post-surge DEMs allow direct quantification of the sediment volumes that were re-distributed in the forefield by the surging ice mass in 1964...... architecture occurs distal to the 1810 ice margin, where the 1890 surge advanced over hitherto undeformed sediments. Proximal to the 1810 ice margin, the landscape have been transgressed by either one or two glaciers (in 1890 and 1964). The most complex landscape architecture is found proximal to the 1964 ice...

  4. PD-1/PD-Ls: A New Target for Regulating Immunopathogenesis in Central Nervous System Disorders.

    Science.gov (United States)

    Wu, Jie; Yu, Zhengquan; Chen, Gang

    2017-09-06

    Immune responses including Microglia and macrophage activation and peripheral immune cells infiltration have been founded in the central nervous system (CNS) in recent years. Thus, the traditional view of the adult brain as an immune-privileged organ has been changed. A systematic literature search was performed using Pubmed and Embase electronic databases without any limitations for a retrospective analysis. The increase a number of studies indicated that the PD-1(programmed cell death-1)/PD-Ls signal pathway played an important role in regulating the immunopathogenesis of brain after injured. The relevant knowledges about PD-1/PD-Ls signal pathway, and potential effect with immune cells, cerebral ischemia, brain tumors and multiple sclerosis were reviewed in this paper. PD-1/PD-Ls played important roles in maintaining immunity balance and the development and prognosis of CNS diseases, but the specific mechanism was still not well understood. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. Spontaneous T-cell responses against the immune check point programmed-death-ligand 1 (PD-L1) in patients with chronic myeloproliferative neoplasms correlate with disease stage and clinical response

    DEFF Research Database (Denmark)

    Holmström, Morten Orebo; Riley, Caroline Hasselbalch; Skov, Vibe

    2018-01-01

    The Chronic Myeloproliferative Neoplasms (MPN) are cancers characterized by hyperinflammation and immune deregulation. Concurrently, the expression of the immune check point programmed death ligand 1 (PD-L1) is induced by inflammation. In this study we report on the occurrence of spontaneous T cell...... responses against a PD-L1 derived epitope in patients with MPN. We show that 71% of patients display a significant immune response against PD-L1, and patients with advanced MPN have significantly fewer and weaker PD-L1 specific immune responses compared to patients with non-advanced MPN. The PD-L1 specific...... T cell responses are CD4+ T cell responses, and by gene expression analysis we show that expression of PD-L1 is enhanced in patients with MPN. This could imply that the tumor specific immune response in MPN could be enhanced by vaccination with PD-L1 derived epitopes by boosting the anti...

  6. Protocol of a single group prospective observational study on the diagnostic value of 3T susceptibility weighted MRI of nigrosome-1 in patients with parkinsonian symptoms: the N3iPD study (nigrosomal iron imaging in Parkinson's disease).

    Science.gov (United States)

    Schwarz, Stefan T; Xing, Yue; Naidu, Saadnah; Birchall, Jim; Skelly, Rob; Perkins, Alan; Evans, Jonathan; Sare, Gill; Martin-Bastida, Antonio; Bajaj, Nin; Gowland, Penny; Piccini, Paola; Auer, Dorothee P

    2017-12-14

    Parkinson's disease (PD) is the most common movement disorder in the elderly and is characterised clinically by bradykinesia, tremor and rigidity. Diagnosing Parkinson's can be difficult especially in the early stages. High-resolution nigrosome MRI offers promising diagnostic accuracy of patients with established clinical symptoms; however, it is unclear whether this may help to establish the diagnosis in the early stages of PD, when there is diagnostic uncertainty. In this scenario, a single photon emission CT scan using a radioactive dopamine transporter ligand can help to establish the diagnosis, or clinical follow-up may eventually clarify the diagnosis. A non-invasive, cost-effective diagnostic test that could replace this would be desirable. We therefore aim to prospectively test whether nigrosome MRI is as useful as DaTSCAN to establish the correct diagnosis in people with minor or unclear symptoms suspicious for PD. In a prospective study we will recruit 145 patients with unclear symptoms possibly caused by Parkinson's from three movement disorder centres in the UK to take part in the study. We will record the Movement Disorder Society - Unified Parkinson's Disease Rating Scale, and participants will undergo DaTSCAN and high-resolution susceptibility weighted MRI at a field strength of 3T. DaTSCANs will be assessed visually and semiquantitatively; MRI scans will be visually assessed for signal loss in nigrosome-1 by blinded investigators. We will compare how the diagnosis suggested by MRI compares with the diagnosis based on DaTSCAN and will also validate the diagnosis based on the two tests with a clinical examination performed at least 1 year after the initial presentation as a surrogate gold standard diagnostic test. The local ethics commission (Health Research Authority East Midlands - Derby Research Ethics Committee) has approved this study (REC ref.: 16/EM/0229). The study is being carried out under the principles of the Declaration of Helsinki (64

  7. Influence of dynorphin on estradiol- and cervical stimulation-induced prolactin surges in ovariectomized rats.

    Science.gov (United States)

    Stathopoulos, Andrea M; Helena, Cleyde V; Cristancho-Gordo, Ruth; Gonzalez-Iglesias, Arturo E; Bertram, Richard

    2016-08-01

    Prolactin is an anterior pituitary hormone necessary for fertility, pregnancy maintenance, lactation, and aspects of maternal behavior. In rodents, there is a surge of prolactin on the afternoon of proestrus, and a semi-circadian pattern of prolactin surges during early pregnancy, with a diurnal and nocturnal surge every day. Both of these patterns can be replicated in ovariectomized rats. A prior study demonstrated that central antagonism of κ-opioid receptors, the target of dynorphin, largely abolished the nocturnal prolactin surge in pregnant rats. We build on this to determine whether dynorphin, perhaps from the arcuate population that co-express kisspeptin, neurokinin B, and dynorphin (KNDy neurons), also contributes to the estradiol- or cervical stimulation-induced surges in ovariectomized rats. Ovariectomized rats were treated with either estradiol or cervical stimulation to induce prolactin surge(s). Blood samples were taken around the expected surge time to determine the effect of either acute κ-opioid receptor antagonism or previous chemical ablation of the KNDy population on prolactin levels. Dynorphin antagonism does significantly disrupt the nocturnal prolactin surge, but it does not contribute to the estradiol-induced surge. Chemical ablation of KNDy neurons had opposite effects; ablation of 40 % of the KNDy neurons had no impact on the nocturnal prolactin surge, while a somewhat larger ablation significantly reduced the size of the estradiol-induced surge. We conclude that dynorphin is likely a controlling factor for the nocturnal surge induced by cervical stimulation, and that other KNDy neuron products must play a role in the estradiol-induced surge.

  8. Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.

    Directory of Open Access Journals (Sweden)

    Naoya Maekawa

    Full Text Available Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads researchers to investigate novel therapeutic modalities, including immunotherapy. Programmed death 1 (PD-1 is a costimulatory receptor with immunosuppressive function. When it binds its ligands, PD-ligand 1 (PD-L1 or PD-L2, PD-1 on T cells negatively regulates activating signals from the T cell receptor, resulting in the inhibition of the effector function of cytotoxic T lymphocytes. Aberrant PD-L1 expression has been reported in many human cancers and is considered an immune escape mechanism for cancers. In clinical trials, anti-PD-1 or anti-PD-L1 antibodies induced tumor regression for several malignancies, including advanced melanoma, non-small cell lung carcinoma, and renal cell carcinoma. In this study, to assess the potential of the PD-1/PD-L1 axis as a novel therapeutic target for canine cancer immunotherapy, immunohistochemical analysis of PD-L1 expression in various malignant cancers of dogs was performed. Here, we show that dog oral melanoma, osteosarcoma, hemangiosarcoma, mast cell tumor, mammary adenocarcinoma, and prostate adenocarcinoma expressed PD-L1, whereas some other types of cancer did not. In addition, PD-1 was highly expressed on tumor-infiltrating lymphocytes obtained from oral melanoma, showing that lymphocytes in this cancer type might have been functionally exhausted. These results strongly encourage the clinical application of PD-1/PD-L1 inhibitors as novel therapeutic agents against these cancers in dogs.

  9. Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.

    Science.gov (United States)

    Maekawa, Naoya; Konnai, Satoru; Okagawa, Tomohiro; Nishimori, Asami; Ikebuchi, Ryoyo; Izumi, Yusuke; Takagi, Satoshi; Kagawa, Yumiko; Nakajima, Chie; Suzuki, Yasuhiko; Kato, Yukinari; Murata, Shiro; Ohashi, Kazuhiko

    2016-01-01

    Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads researchers to investigate novel therapeutic modalities, including immunotherapy. Programmed death 1 (PD-1) is a costimulatory receptor with immunosuppressive function. When it binds its ligands, PD-ligand 1 (PD-L1) or PD-L2, PD-1 on T cells negatively regulates activating signals from the T cell receptor, resulting in the inhibition of the effector function of cytotoxic T lymphocytes. Aberrant PD-L1 expression has been reported in many human cancers and is considered an immune escape mechanism for cancers. In clinical trials, anti-PD-1 or anti-PD-L1 antibodies induced tumor regression for several malignancies, including advanced melanoma, non-small cell lung carcinoma, and renal cell carcinoma. In this study, to assess the potential of the PD-1/PD-L1 axis as a novel therapeutic target for canine cancer immunotherapy, immunohistochemical analysis of PD-L1 expression in various malignant cancers of dogs was performed. Here, we show that dog oral melanoma, osteosarcoma, hemangiosarcoma, mast cell tumor, mammary adenocarcinoma, and prostate adenocarcinoma expressed PD-L1, whereas some other types of cancer did not. In addition, PD-1 was highly expressed on tumor-infiltrating lymphocytes obtained from oral melanoma, showing that lymphocytes in this cancer type might have been functionally exhausted. These results strongly encourage the clinical application of PD-1/PD-L1 inhibitors as novel therapeutic agents against these cancers in dogs.

  10. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Sueño, Parte 1 Expert Briefings: What's in the PD Pipeline? Gene and Cell Therapies Expert Briefings: Dealing with Dementia in PD Expert Briefings: Anxiety in Parkinson's Disease Expert Briefings: Nutrition and ... PD Medications: Get the Most Out of Your Treatment Plan Expert Briefings: ...

  11. Direct Surge Margin Control for Aeroengines Based on Improved SVR Machine and LQR Method

    Directory of Open Access Journals (Sweden)

    Haibo Zhang

    2013-01-01

    Full Text Available A novel scheme of high stability engine control (HISTEC on the basis of an improved linear quadratic regulator (ILQR, called direct surge margin control, is derived for super-maneuver flights. Direct surge margin control, which is different from conventional control scheme, puts surge margin into the engine closed-loop system and takes surge margin as controlled variable directly. In this way, direct surge margin control can exploit potential performance of engine more effectively with a decrease of engine stability margin which usually happened in super-maneuver flights. For conquering the difficulty that aeroengine surge margin is undetectable, an approach based on improved support vector regression (SVR machine is proposed to construct a surge margin prediction model. The surge margin modeling contains two parts: a baseline model under no inlet distortion states and the calculation for surge margin loss under supermaneuvering flight conditions. The previous one is developed using neural network method, the inputs of which are selected by a weighted feature selection algorithm. Considering the hysteresis between pilot input and angle of attack output, an online scrolling window least square support vector regression (LSSVR method is employed to firstly estimate inlet distortion index and further compute surge margin loss via some empirical look-up tables.

  12. Remote Sensing Observations of Advancing and Surging Tidewater Glaciers

    Science.gov (United States)

    McNabb, R. W.; Kääb, A.; Nuth, C.; Girod, L.; Truffer, M.; Fahnestock, M. A.

    2017-12-01

    Progress has been made in understanding the glaciological frontiers of tidewater glacier dynamics and surge dynamics, though many aspects of these topics are not well-understood. Advances in the processing of digital elevation models (DEMs) from ASTER imagery, as well as the increased availability and temporal density of satellite images such as Landsat and the Sentinel missions, provide an unprecedented wealth of satellite data over glaciers, providing new opportunities to learn about these topics. As one of the largest glaciated regions in the world outside of the Greenland and Antarctic ice sheets, glaciers in Alaska and adjacent regions in Canada have been highlighted for their elevated contributions to global sea level rise, through both high levels of melt and frontal ablation/calving from a large number of tidewater glaciers. The region is also home to a number of surging glaciers. We focus on several tidewater glaciers in the region, including Turner, Tsaa, Harvard, and Meares Glaciers. Turner Glacier is a surge-type tidewater glacier with a surge period of approximately eight years, while Tsaa Glacier is a tidwewater glacier that has shown rapid swings in terminus position on the order of a year. Harvard and Meares Glaciers have been steadily advancing since at least the mid-20th century, in contrast with neighboring glaciers that are retreating. Using a combination of ASTER, Landsat, and Sentinel data, we present and examine high-resolution time series of elevation, velocity, and terminus position for these glaciers, as well as updated estimates of volume change and frontal ablation rates, including on sub-annual time scales. Preliminary investigations of elevation change on Turner Glacier show that changes are most pronounced in the lower reaches of the glacier, below a prominent icefall approximately 15km from the head of the glacier. On Harvard and Meares Glaciers, elevation changes in the upper reaches of both glaciers have been generally small or

  13. High Resolution Hurricane Storm Surge and Inundation Modeling (Invited)

    Science.gov (United States)

    Luettich, R.; Westerink, J. J.

    2010-12-01

    Coastal counties are home to nearly 60% of the U.S. population and industry that accounts for over 16 million jobs and 10% of the U.S. annual gross domestic product. However, these areas are susceptible to some of the most destructive forces in nature, including tsunamis, floods, and severe storm-related hazards. Since 1900, tropical cyclones making landfall on the US Gulf of Mexico Coast have caused more than 9,000 deaths; nearly 2,000 deaths have occurred during the past half century. Tropical cyclone-related adjusted, annualized losses in the US have risen from 1.3 billion from 1949-1989, to 10.1 billion from 1990-1995, and $35.8 billion per year for the period 2001-2005. The risk associated with living and doing business in the coastal areas that are most susceptible to tropical cyclones is exacerbated by rising sea level and changes in the characteristics of severe storms associated with global climate change. In the five years since hurricane Katrina devastated the northern Gulf of Mexico Coast, considerable progress has been made in the development and utilization of high resolution coupled storm surge and wave models. Recent progress will be presented with the ADCIRC + SWAN storm surge and wave models. These tightly coupled models use a common unstructured grid in the horizontal that is capable of covering large areas while also providing high resolution (i.e., base resolution down to 20m plus smaller subgrid scale features such as sea walls and levees) in areas that are subject to surge and inundation. Hydrodynamic friction and overland winds are adjusted to account for local land cover. The models scale extremely well on modern high performance computers allowing rapid turnaround on large numbers of compute cores. The models have been adopted for FEMA National Flood Insurance Program studies, hurricane protection system design and risk analysis, and quasi-operational forecast systems for several regions of the country. They are also being evaluated as

  14. Vulnerability of Coastal Communities from Storm Surge and Flood Disasters

    Science.gov (United States)

    Bathi, Jejal Reddy; Das, Himangshu S.

    2016-01-01

    Disasters in the form of coastal storms and hurricanes can be very destructive. Preparing for anticipated effects of such disasters can help reduce the public health and economic burden. Identifying vulnerable population groups can help prioritize resources for the most needed communities. This paper presents a quantitative framework for vulnerability measurement that incorporates both socioeconomic and flood inundation vulnerability. The approach is demonstrated for three coastal communities in Mississippi with census tracts being the study unit. The vulnerability results are illustrated as thematic maps for easy usage by planners and emergency responders to assist in prioritizing their actions to vulnerable populations during storm surge and flood disasters. PMID:26907313

  15. Vulnerability of Coastal Communities from Storm Surge and Flood Disasters.

    Science.gov (United States)

    Bathi, Jejal Reddy; Das, Himangshu S

    2016-02-19

    Disasters in the form of coastal storms and hurricanes can be very destructive. Preparing for anticipated effects of such disasters can help reduce the public health and economic burden. Identifying vulnerable population groups can help prioritize resources for the most needed communities. This paper presents a quantitative framework for vulnerability measurement that incorporates both socioeconomic and flood inundation vulnerability. The approach is demonstrated for three coastal communities in Mississippi with census tracts being the study unit. The vulnerability results are illustrated as thematic maps for easy usage by planners and emergency responders to assist in prioritizing their actions to vulnerable populations during storm surge and flood disasters.

  16. THE CHALLENGE OF PD PATIENTS: GLUCOSE AND GLUCOSE DEGRADATION PRODUCTS IN PD SOLUTION

    Directory of Open Access Journals (Sweden)

    Yong-Lim Kim

    2012-06-01

    Full Text Available The main osmotic agent found in the peritoneal dialysis (PD solution is glucose. It has been of a wide use for great crystalloid osmotic power at a low concentration, simple metabolism, and excellent safety. On the other hand, anywhere between 60 to 80% of the glucose in the PD solution is absorbed - a 100 to 300 mg of daily glucose absorption. Once into the systemic circulation, glucose can be a cause for metabolic complications including obesity. Indeed, the diabetiform change observed in the peritoneal membrane in the long-term PD patients is believed attributable to the high-concentration glucose in the PD solution. The glucose absorbed from peritoneal cavity raises the risk of ‘glucose toxicity’, leading to insulin resistance and beta cell failure. Clinical similarity can be found in postprandial hyperglycemia, which is known to be associated with oxidative stress, endothelial dysfunction, NF-κb, and inflammation, affecting myocardial blood flow. Moreover, it is a proven independent risk factor of coronary artery disease in patients with type 2 diabetes, particularly of female gender. Though speculative yet, glucose toxicity might explain a higher mortality of PD patients after the first year compared with those on hemodialysis (more so in female, advanced-age patients with diabetes. Also included in the picture are glucose degradation products (GDPs generated along the course of heat sterilization or storage of the PD solution. They have been shown to induce apoptosis of peritoneal mesothelial cells, renal tubular epithelial cells, and endothelial cells, while spurring production of TGF-β and VEGF and facilitating epithelial mesenchymal transition. GDPs provide a stronger reactivity than glucose in the formation of AGEs, a known cause for microvascular complications and arteriosclerosis. Unfortunately, clinical studies using a low-GDP PD solution have provided mixed results on the residual renal function, peritonitis, peritoneal

  17. PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile.

    Science.gov (United States)

    Pizarro, Carolina; García-Díaz, Diego F; Codner, Ethel; Salas-Pérez, Francisca; Carrasco, Elena; Pérez-Bravo, Francisco

    2014-11-01

    Type 1 diabetes (T1D) has a complex etiology in which genetic and environmental factors are involved, whose interactions have not yet been completely clarified. In this context, the role in PD-1 pathway and its ligands 1 and 2 (PD-L1 and PD-L2) have been proposed as candidates in several autoimmune diseases. The aim of this work was to determine the allele and haplotype frequency of six gene polymorphisms of PD-ligands (PD-L1 and PD-L2) in Chilean T1D patients and their effect on serum levels of PD-L1 and autoantibody profile (GAD65 and IA2). This study cohort comprised 205 T1D patients and 205 normal children. We performed genotypic analysis of PD-L1 and PD-L2 genes by TaqMan method. Determination of anti-GAD65 and anti-IA-2 autoantibodies was performed by ELISA. The PD-L1 serum levels were measured. The allelic distribution of PD-L1 variants (rs2297137 and rs4143815) showed differences between T1D patients and controls (p = 0.035 and p = 0.022, respectively). No differences were detected among the PD-L2 polymorphisms, and only the rs16923189 showed genetic variation. T1D patients showed decreased serum levels of PD-L1 compared to controls: 1.42 [0.23-7.45] ng/mL versus 3.35 [0.49-5.89] ng/mL (p diabetics patients. Moreover, the age of onset of the disease determine differences between serum ligand levels in diabetics, being lower in younger. These results points to a possible establishment of PDL-1 as a genetic and biochemical marker for T1D onset, at least in Chilean population. Copyright © 2014 John Wiley & Sons, Ltd.

  18. Multidecadal Scale Detection Time for Potentially Increasing Atlantic Storm Surges in a Warming Climate

    Science.gov (United States)

    Lee, Benjamin Seiyon; Haran, Murali; Keller, Klaus

    2017-10-01

    Storm surges are key drivers of coastal flooding, which generate considerable risks. Strategies to manage these risks can hinge on the ability to (i) project the return periods of extreme storm surges and (ii) detect potential changes in their statistical properties. There are several lines of evidence linking rising global average temperatures and increasingly frequent extreme storm surges. This conclusion is, however, subject to considerable structural uncertainty. This leads to two main questions: What are projections under various plausible statistical models? How long would it take to distinguish among these plausible statistical models? We address these questions by analyzing observed and simulated storm surge data. We find that (1) there is a positive correlation between global mean temperature rise and increasing frequencies of extreme storm surges; (2) there is considerable uncertainty underlying the strength of this relationship; and (3) if the frequency of storm surges is increasing, this increase can be detected within a multidecadal timescale (≈20 years from now).

  19. Facilitating Adaptation to Changing Storm Surge Patterns in Western Alaska.

    Science.gov (United States)

    Murphy, K. A.; Holman, A.; Reynolds, J.

    2014-12-01

    Coastal regions of North America are already experiencing the effects of climate change and the consequences of new storm patterns and sea level rise. These climate change effects are even more pronounced in western Alaska where the loss of sea ice in early winter and spring are exposing the coast to powerful winter storms that are visibly altering the landscape, putting coastal communities at risk, and are likely impacting important coastal wildlife habitat in ways we don't yet understand. The Western Alaska Landscape Conservation Cooperative has funded a suite of projects to improve the information available to assist managers and communities to adapt changes in coastal storms and their impacts. Projects range from modeling tide, wave and storm surge patters, to ShoreZone and NHD mapping, to bathymetry mapping, community vulnerability assessments and risks to important wildlife habitat. This group of diverse projects has helped stimulate momentum among partners which will lead to better tools for communities to respond to dangerous storms. For example, the State of Alaska and NOAA are working together to compile a series of community-scale maps that utilize best-available datasets to streamline communication about forecasted storm surges, local elevations and potentially impacted infrastructure during storm events that may lead to coastal flooding.

  20. A Comparison of Ensemble Kalman Filters for Storm Surge Assimilation

    KAUST Repository

    Altaf, Muhammad

    2014-08-01

    This study evaluates and compares the performances of several variants of the popular ensembleKalman filter for the assimilation of storm surge data with the advanced circulation (ADCIRC) model. Using meteorological data from Hurricane Ike to force the ADCIRC model on a domain including the Gulf ofMexico coastline, the authors implement and compare the standard stochastic ensembleKalman filter (EnKF) and three deterministic square root EnKFs: the singular evolutive interpolated Kalman (SEIK) filter, the ensemble transform Kalman filter (ETKF), and the ensemble adjustment Kalman filter (EAKF). Covariance inflation and localization are implemented in all of these filters. The results from twin experiments suggest that the square root ensemble filters could lead to very comparable performances with appropriate tuning of inflation and localization, suggesting that practical implementation details are at least as important as the choice of the square root ensemble filter itself. These filters also perform reasonably well with a relatively small ensemble size, whereas the stochastic EnKF requires larger ensemble sizes to provide similar accuracy for forecasts of storm surge.

  1. Do surges heat the corona. [dense chromospheric ejecta accompanied by X ray bursts

    Science.gov (United States)

    Rust, D. M.; Webb, D. F.; Maccombie, W.

    1977-01-01

    A comparison of X-ray filtergrams obtained during the Skylab mission 8 hr before and within 4 hr following 54 active region surges on the disk revealed only 6 cases of long-enduring, large-scale (exceeding 10,000 km) coronal enhancements that might have been associated with surge activity. It is concluded that there is no evidence for any substantial increase in the temperature or amount of coronal material during reported surges.

  2. Characteristics and possibilities of software tool for metal-oxide surge arresters selection

    Directory of Open Access Journals (Sweden)

    Đorđević Dragan

    2012-01-01

    Full Text Available This paper presents a procedure for the selection of metal-oxide surge arresters based on the instructions given in the Siemens and ABB catalogues, respecting their differences and the characteristics and possibilities of the software tool. The software tool was developed during the preparation of a Master's thesis titled, 'Automation of Metal-Oxide Surge Arresters Selection'. An example is presented of the selection of metal-oxide surge arresters using the developed software tool.

  3. Prevalence and characteristics of dementia in Parkinson disease

    DEFF Research Database (Denmark)

    Aarsland, Dag; Andersen, Kjeld; Larsen, Jan P

    2003-01-01

    Few longitudinal studies of dementia in Parkinson disease (PD) have been reported, and the proportion of patients with PD who eventually develop dementia is unknown.......Few longitudinal studies of dementia in Parkinson disease (PD) have been reported, and the proportion of patients with PD who eventually develop dementia is unknown....

  4. SURGTANK, Steam Pressure, Saturation Temperature or Reactor Surge Tank

    International Nuclear Information System (INIS)

    Gorman, D.J.; Gupta, R.K.

    2001-01-01

    1 - Description of problem or function: SURGTANK generates the steam pressure, saturation temperature, and ambient temperature history for a nuclear reactor steam surge tank (pressurizer) in a state of thermodynamic equilibrium subjected to a liquid insurge described by a specified time history of liquid levels. It is capable also of providing the pressure and saturation temperature history, starting from thermodynamic equilibrium conditions, for the same tank subjected to an out-surge described by a time history of liquid levels. Both operations are available for light- or heavy- water nuclear reactor systems. The tank is assumed to have perfect thermal insulation on its outer wall surfaces. 2 - Method of solution: Surge tank geometry and initial liquid level and saturation pressure are provided as input for the out-surge problem, along with the prescribed time-sequence level history. SURGTANK assumes a reduced pressure for the end of the first change in liquid level and determines the associated change of entropy for the closed system. The assumed pressure is adjusted and the associated change in entropy recalculated until a pressure is attained for which no change occurs. This pressure is recorded and used as the beginning pressure for the next level increment. The system is then re-defined to exclude the small amount of liquid which has left the tank, and a solution for the pressure at the end of the second level increment is obtained. The procedure is terminated when the pressure at the end of the final increment has been determined. Surge tank geometry, thermal conductivity, specific heat, and density of tank walls, initial liquid level, and saturation pressure are provided as input for the insurge problem, along with the prescribed time-sequence level history. SURGTANK assumes a slightly in- creased pressure for the end of the first level, the inner tank sur- face is assumed to follow saturation temperature, linearly with time, throughout the interval, and

  5. The Development of Storm Surge Ensemble Prediction System and Case Study of Typhoon Meranti in 2016

    Science.gov (United States)

    Tsai, Y. L.; Wu, T. R.; Terng, C. T.; Chu, C. H.

    2017-12-01

    Taiwan is under the threat of storm surge and associated inundation, which is located at a potentially severe storm generation zone. The use of ensemble prediction can help forecasters to know the characteristic of storm surge under the uncertainty of track and intensity. In addition, it can help the deterministic forecasting. In this study, the kernel of ensemble prediction system is based on COMCOT-SURGE (COrnell Multi-grid COupled Tsunami Model - Storm Surge). COMCOT-SURGE solves nonlinear shallow water equations in Open Ocean and coastal regions with the nested-grid scheme and adopts wet-dry-cell treatment to calculate potential inundation area. In order to consider tide-surge interaction, the global TPXO 7.1 tide model provides the tidal boundary conditions. After a series of validations and case studies, COMCOT-SURGE has become an official operating system of Central Weather Bureau (CWB) in Taiwan. In this study, the strongest typhoon in 2016, Typhoon Meranti, is chosen as a case study. We adopt twenty ensemble members from CWB WRF Ensemble Prediction System (CWB WEPS), which differs from parameters of microphysics, boundary layer, cumulus, and surface. From box-and-whisker results, maximum observed storm surges were located in the interval of the first and third quartile at more than 70 % gauge locations, e.g. Toucheng, Chengkung, and Jiangjyun. In conclusion, the ensemble prediction can effectively help forecasters to predict storm surge especially under the uncertainty of storm track and intensity

  6. Surge protective device response to steep front transient in low voltage circuit

    Energy Technology Data Exchange (ETDEWEB)

    Marcuz, J.; Binczak, S.; Bilbault, J.M. [Universite de Bourgogne, Dijon (France)], Emails: jerome.marcuz@ laposte.net, stbinc@u-bourgogne.fr, bilbault@u-bourgogne.fr; Girard, F. [ADEE Electronic, Pont de Pany (France)

    2007-07-01

    Surge propagation on cables of electrical or data lines leads to a major protection problem as the number of equipment based on solid-state circuits or microprocessors increases. Sub-microsecond components of real surge waveform has to be taken into account for a proper protection even in the case of surges caused by indirect lightning effects. The response of a model of transient voltage suppressor diode based surge protection device (SPD) to fast front transient is analytically studied, then compared to simulations, including the lines connected to the SPD and to the protected equipment. (author)

  7. Vulnerability assessment of storm surges in the coastal area of Guangdong Province

    Directory of Open Access Journals (Sweden)

    K. Li

    2011-07-01

    Full Text Available Being bordered by the South China Sea and with long coastline, the coastal zone of Guangdong Province is often under severe risk of storm surges, as one of a few regions in China which is seriously threatened by storm surges. This article systematically analyzes the vulnerability factors of storm surges in the coastal area of Guangdong (from Yangjing to Shanwei. Five vulnerability assessment indicators of hazard-bearing bodies are proposed, which are social economic index, land use index, eco-environmental index, coastal construction index, and disaster-bearing capability index. Then storm surge vulnerability assessment index system in the coastal area of Guangdong is established. Additionally, the international general mode about coastal vulnerability assessment is improved, and the vulnerability evolution model of storm surges in the coastal area of Guangdong is constructed. Using ArcGIS, the vulnerability zoning map of storm surges in the study region is drawn. Results show that there is the highest degree of storm surge vulnerability in Zhuhai, Panyu, and Taishan; second in Zhongshan, Dongguan, Huiyang, and Haifeng; third in Jiangmen, Shanwei, Yangjiang, and Yangdong; fourth in Baoan, Kaiping, and Enping; and lowest in Guangzhou, Shunde, Shenzhen, and Longgang. This study on the risk of storm surges in these coastal cities can guide the land use of coastal cities in the future, and provide scientific advice for the government to prevent and mitigate the storm surge disasters. It has important theoretical and practical significance.

  8. Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups.

    Science.gov (United States)

    Jin, Xue; Shi, Xiaoxia; Gao, Jintian; Xu, Tongbin; Yin, Kedong

    2018-03-27

    Storm surge has become an important factor restricting the economic and social development of China's coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM) model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation.

  9. Numerical modelling of tides and storm surges in the Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Sindhu, B.

    The destruction due to storm surge flooding is a serious concern along the coast of Bay of Bengal. Amongst other natural disasters affecting the coast of India and Bangladesh, storm surges stand out, so far, as the most damaging and as an agent of death... are at higher risks of flooding during cyclonic events. In addition, tidal ranges in the northern Bay of Bengal are very high and the destruction caused by surges can be massive if the surges occur at the time of high tide. Thus real time monitoring...

  10. A prediction of storm surge using the artificial neural networks (ANNs) based on a JTWC best track and tide-surge model

    Science.gov (United States)

    Park, Junghyun; Yuk, Jin-Hee; An, Jooneun; Joh, Minsu; Kim, Seung-woo

    2017-04-01

    There is huge damage caused by tropical typhoons every year in the South Korea. The storm surge due to landing of typhoon leads to severe flooding and casualty damage in coastal areas. Generally, the storm surge height is defined as the difference between the sea levels observed and predicted considering tide only. This advancing surge combines with the normal tides to create the typhoon storm surge height, which can increase the mean water level from only 1 to more than 2 m by the typhoon characteristics in Korea. To efficiently describe the phenomenon of storm surge in the coastal area, many researchers have used the numerical model of fluid dynamics. However, recently, research activities based on not the numerical model but big data have gotten a lot of attention and the Artificial Neural Networks (ANNs) among these activities have shown powerful pattern classification and pattern recognition capabilities. The ANNs provide an attractive alternative tool for both forecasting researchers and practitioners. In particular, the ANNs have been widely applied to various areas to overcome the nonlinear natural disaster problems. This paper is aimed to propose the application of the ANNs for prediction of the storm surge. Many storm surge data stored for a long time are required to predict storm surge accurately using ANNs. But, because of the lack of storm surge data in the past years, we calculated storm surges due to 53 typhoons which had affected the South Korea from 1978 to 2014 using a finite element tide-surge model (ADvanced CIRCulation Model) and the typhoon information of JTWC (Joint Typhoon Warning Center). Factors such as the six hourly best track data of typhoon, head direction and velocity of typhoons, maximum sustained wind speed, minimum sea level pressure, radius of the last closed isobar, and radius of max winds were used to test the accuracy of the suggested ANNs model. The normalized root mean squared error (RMSE) and correlation coefficient (CC

  11. Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases.

    Science.gov (United States)

    Doustar, Jonah; Torbati, Tania; Black, Keith L; Koronyo, Yosef; Koronyo-Hamaoui, Maya

    2017-01-01

    Over the past decade, a surge of evidence has documented various pathological processes in the retina of patients suffering from mild cognitive impairment, Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative diseases. Numerous studies have shown that the retina, a central nervous system tissue formed as a developmental outgrowth of the brain, is profoundly affected by AD. Harboring the earliest detectable disease-specific signs, amyloid β-protein (Aβ) plaques, the retina of AD patients undergoes substantial ganglion cell degeneration, thinning of the retinal nerve fiber layer, and loss of axonal projections in the optic nerve, among other abnormalities. More recent investigations described Aβ plaques in the retina located within sites of neuronal degeneration and occurring in clusters in the mid- and far-periphery of the superior and inferior quadrants, regions that had been previously overlooked. Diverse structural and/or disease-specific changes were also identified in the retina of PD, Huntington's disease, and multiple sclerosis patients. The pathological relationship between the retina and brain prompted the development of imaging tools designed to noninvasively detect and monitor these signs in living patients. One such tool is optical coherence tomography (OCT), uniquely providing high-resolution two-dimensional cross-sectional imaging and three-dimensional volumetric measurements. As such, OCT emerged as a prominent approach for assessing retinal abnormalities in vivo , and indeed provided multiple parameters that allowed for the distinction between normal aged individuals and patients with neurodegenerative diseases. Beyond the use of retinal optical fundus imaging, which recently allowed for the detection and quantification of amyloid plaques in living AD patients via a wide-field view of the peripheral retina, a major advantage of OCT has been the ability to measure the volumetric changes in specified retinal layers. OCT

  12. A Malaysia 97 monovalent foot-and-mouth disease vaccine (>6PD50/dose) protects pigs against challenge with a variant FMDV A SEA-97 lineage virus, 4 and 7 days post vaccination.

    Science.gov (United States)

    Nagendrakumar, Singanallur Balasubramanian; Hong, Nguyen Thi Thu; Geoffrey, Fosgate T; Jacqueline, Morris Michelle; Andrew, Davis; Michelle, Giles; Van Phuc, Kim; Ngon, Quach Vo; Phuong, Le Thi Thu; Phuc, Nguyen Ngoc Hong; Hanh, Tran Xuan; Van Hung, Vo; Quynhanh, Le Thi; Tan, Tran Minh; Long, Ngo Thanh; Wilna, Vosloo

    2015-08-26

    Pigs play a significant role during outbreaks of foot-and-mouth disease (FMD) due to their ability to amplify the virus. It is therefore essential to determine what role vaccination could play to prevent clinical disease and lower virus excretion into the environment. In this study we investigated the efficacy of the double oil emulsion A Malaysia 97 vaccine (>6PD50/dose) against heterologous challenge with an isolate belonging to the A SEA-97 lineage at 4 and 7 days post vaccination (dpv). In addition, we determined whether physical separation of pigs in the same room could prevent virus transmission. Statistically there was no difference in the level of protection offered by 4 and 7 dpv. However, no clinical disease or viral RNA was detected in the blood of pigs challenged 4 dpv, although three of the pigs had antibodies to the non-structural proteins (NSPs), indicating viral replication. Viral RNA was also detected in nasal and saliva swabs, but on very few occasions. Two of the pigs vaccinated seven days prior to challenge had vesicles distal from the injection site, but on the inoculated foot, and two pigs had viral RNA detected in the blood. One pig sero-converted to the NSPs. In contrast, all unvaccinated and inoculated pigs had evidence of infection. No infection occurred in any of the susceptible pigs in the same room, but separated from the infected pigs, indicating that strict biosecurity measures were sufficient under these experimental conditions to prevent virus transmission. However, viral RNA was detected in the nasal swabs of one group of pigs, but apparently not at sufficient levels to cause clinical disease. Vaccination led to a significant decrease in viral RNA in vaccinated pigs compared to unvaccinated and infected pigs, even with this heterologous challenge, and could therefore be considered as a control option during outbreaks. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. Glucose-6-phosphate dehydrogenase (G6PD mutations and haemoglobinuria syndrome in the Vietnamese population

    Directory of Open Access Journals (Sweden)

    Day Nick

    2009-07-01

    Full Text Available Abstract Background In Vietnam the blackwater fever syndrome (BWF has been associated with malaria infection, quinine ingestion and G6PD deficiency. The G6PD variants within the Vietnamese Kinh contributing to the disease risk in this population, and more generally to haemoglobinuria, are currently unknown. Method Eighty-two haemoglobinuria patients and 524 healthy controls were screened for G6PD deficiency using either the methylene blue reduction test, the G-6-PDH kit or the micro-methaemoglobin reduction test. The G6PD gene variants were screened using SSCP combined with DNA sequencing in 82 patients with haemoglobinuria, and in 59 healthy controls found to be G6PD deficient. Results This study confirmed that G6PD deficiency is strongly associated with haemoglobinuria (OR = 15, 95% CI [7.7 to 28.9], P G6PD variants were identified in the Vietnamese population, of which two are novel (Vietnam1 [Glu3Lys] and Vietnam2 [Phe66Cys]. G6PD Viangchan [Val291Met], common throughout south-east Asia, accounted for 77% of the variants detected and was significantly associated with haemoglobinuria within G6PD-deficient ethnic Kinh Vietnamese (OR = 5.8 95% CI [114-55.4], P = 0.022. Conclusion The primary frequency of several G6PD mutations, including novel mutations, in the Vietnamese Kinh population are reported and the contribution of G6PD mutations to the development of haemoglobinuria are investigated.

  14. Parkinson's Disease

    Science.gov (United States)

    ... and to reduce tremors, slowness of movements, and gait problems. DBS requires careful programming of the stimulator device in order to work correctly. View Full Treatment Information Definition Parkinson's disease (PD) belongs to a group of ...

  15. Dependence between sea surge, river flow and precipitation in south and west Britain

    Directory of Open Access Journals (Sweden)

    C. Svensson

    2004-01-01

    Full Text Available Estuaries around Great Britain may be at heightened risk of flooding because of the simultaneous occurrence of extreme sea surge and river flow, both of which may be caused by mid-latitude cyclones. A measure especially suited for extremes was employed to estimate dependence between river flow and sea surge. To assist in the interpretation of why flow-surge dependence occurs in some areas and not in others, the dependence between precipitation and surge and between precipitation and river flow was also studied. Case studies of the meteorological situations leading to high surges and/or river flows were also carried out. The present study concerns catchments draining to the south and west coasts of Great Britain. Statistically significant dependence between river flow and daily maximum sea surge may be found at catchments spread along most of this coastline. However, higher dependence is generally found in catchments in hilly areas with a southerly to westerly aspect. Here, precipitation in south-westerly airflow, which is generally the quadrant of prevailing winds, will be enhanced orographically as the first higher ground is encountered. The sloping catchments may respond quickly to the abundant rainfall and the flow peak may arrive in the estuary on the same day as a large sea surge is produced by the winds and low atmospheric pressure associated with the cyclone. There are three regions where flow-surge dependence is strong: the western part of the English south coast, southern Wales and around the Solway Firth. To reduce the influence of tide-surge interaction on the dependence analysis, the dependence between river flow and daily maximum surge occurring at high tide was estimated. The general pattern of areas with higher dependence is similar to that using the daily maximum surge. The dependence between river flow and daily maximum sea surge is often strongest when surge and flow occur on the same day. The west coast from Wales and

  16. Spatial and temporal variability and long-term trends in skew surges globally

    Directory of Open Access Journals (Sweden)

    Robert eMawdsley

    2016-03-01

    Full Text Available Storm surges and the resulting extreme high sea levels are among the most dangerous natural disasters and are responsible for widespread social, economic and environmental consequences. Using a set of 220 tide gauges, this paper investigates the temporal variations in storm surges around the world and the spatial coherence of its variability. We compare results derived from two parameters used to represent storm surge: skew surge and the more traditional, non-tidal residual. We determine the extent of tide-surge interaction, at each study site, and find statistically significant (95% confidence levels of tide-surge interaction at 59% of sites based on tidal level and 81% of sites based on tidal-phase. The tide-surge interaction was strongest in regions of shallow bathymetry such as the North Sea, north Australia and the Malay Peninsula. At most sites the trends in the skew surge time series were similar to those of non-tidal residuals, but where there were large differences in trends, the sites tended to have a large tidal range. Only 13% of sites had a statistically significant trend in skew surge, and of these approximately equal numbers were positive and negative. However, for trends in the non-tidal residual there are significantly more negative trends. We identified 8 regions where there were strong positive correlations in skew surge variability between sites, which meant that a regional index could be created to represent these groups of sites. Despite, strong correlations between some regional skew surge indices, none are significant at the 95% level, however, at the 80% level there was significant positive correlation between the north-west Atlantic - south and the North Sea. Correlations between the regional skew surge indices and climate indices only became significant at the 80% level, where Nińo 4 was positively correlated with the Gulf of Mexico skew surge index and negatively correlated with the east Australia skew surge index

  17. Increased Level of Morning Surge in Blood Pressure in Normotensives: ACross-Sectional Study from Pakistan.

    Science.gov (United States)

    Almas, Aysha; Sultan, Fatehali Tipoo; Kazmi, Khawar

    2016-10-01

    To determine the mean morning surge (MS) in blood pressure, the frequency of increased morning surge in normotensive subjects, and to compare those with morning surge with those without MS. Across-sectional, comparative study. The Department of Medicine, The Aga Khan University Hospital, Karachi, from April 2011 to March 2012. Adult normotensive healthy volunteers aged 35 to 65 years were inducted. Their ambulatory blood pressure (ABP) was measured over a 24-hour period, using digital ambulatory blood pressure monitors. Morning surge was calculated as the average of four readings after waking minus the lowest three nocturnal readings. Increased morning surge was defined as > 11 mm Hg in systolic (SBP) or > 12 mm Hg in diastolic (DBP). Dipping was defined as > 10% dipping in blood pressure. Eighty-two healthy volunteers were recruited. Their mean age was 36.9 ±1.2 years; 74.4 (61%) were men, and 58.5 (48%) woke up for morning prayers. Mean overall SBPwas 113 ±1.6 mm Hg, overall DBPwas 73.9 ±0.7 mm Hg, and overall heart rate was 75 (10) beats/minute. Mean morning surge was 17.6 ±1.0 mm Hg in SBPand 16.0 ±0.8 mm Hg in DBP. The frequency of increased morning surge was 66 (80.5%) in SBP, and 57 (69%) in DBP. On comparison of participants with normal morning surge and increased morning surge in SBP, there was a significant difference in nondipping status (13.4% in normal vs. 18.3% in increased morning surge, p= 0.001). Mean morning surge in SBPand DBPare relatively higher in this subset population in a tertiary care center in Pakistan. These values are higher than those reported in the literature.

  18. Comparison of two recent storm surge events based on results of field surveys

    Science.gov (United States)

    Nakamura, Ryota; Shibayama, Tomoya; Mikami, Takahito; Esteban, Miguel; Takagi, Hiroshi; Maell, Martin; Iwamoto, Takumu

    2017-10-01

    This paper compares two different types of storm surge disaster based on field surveys. Two cases: a severe storm surge flood with its height of over 5 m due to Typhoon Haiyan (2013) in Philippine, and inundation of storm surge around Nemuro city in Hokkaido of Japan with its maximum surge height of 2.8 m caused by extra-tropical cyclone are taken as examples. For the case of the Typhoon Haiyan, buildings located in coastal region were severely affected due to a rapidly increase in ocean surface. The non-engineering buildings were partially or completely destroyed due to their debris transported to an inner bay region. In fact, several previous reports indicated two unique features, bore-like wave and remarkably high speed currents. These characteristics of the storm surge may contribute to a wide-spread corruption for the buildings around the affected region. Furthermore, in the region where the surge height was nearly 3 m, the wooden houses were completely or partially destroyed. On the other hand, in Nemuro city, a degree of suffering in human and facility caused by the storm surge is minor. There was almost no partially destroyed residential houses even though the height of storm surge reached nearly 2.8 m. An observation in the tide station in Nemuro indicated that this was a usual type of storm surge, which showed a gradual increase of sea level height in several hours without possessing the unique characteristics like Typhoon Haiyan. As a result, not only the height of storm surge but also the robustness of the buildings and characteristics of storm surge, such as bore like wave and strong currents, determined the existent of devastation in coastal regions.

  19. Tide Gauge and Satellite Altimetry Integration for Storm Surge Prediction

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Cheng, Yongcun; Deng, X.

    2013-01-01

    Integrating coarse temporal sampling by the satellite altimeter in the deep ocean with the high temporal sampling at tide gauges in sparse location along the coast has been used to improve the forecast of high water in the North Sea along the Danish Coast and storm surges along the Northeast coast...... gauge recordings and investigated the capability of the satellite altimeters to capture these in the sea surface height. On the European coast we find that when two or more satellites are available we capture more than 90% of the extreme sea level events. In the Great Barrier Reef section...... tide gauges with satellite altimetry for forecasting high water at the city of Townville in North East Australia....

  20. Using satellite altimetry and tide gauges for storm surge warning

    DEFF Research Database (Denmark)

    Andersen, O. B.; Cheng, Yongcun; Deng, X.

    2014-01-01

    The combination of the coarse temporal sampling by satellite altimeters in the deep ocean with the high temporal sampling at sparsely located tide gauges along the coast has been used to improve the forecast of high water for the North Sea along the Danish Coast and for the northeast coast...... selected several representative high water events on the two continents based on tide gauge recordings and investigated the capability of satellite altimetry to capture these events in the sea surface height data. Due to the lack of recent surges in the North Sea we focused on general high water level...... coast in March 2006 and caused both loss of lives as well as huge devastation. Here we demonstrate the importance of integrating tide gauges with satellite altimetry for forecasting high water at the city of Townsville in northeast Australia....

  1. Cognitive impairment in early-stage non-demented Parkinson's disease patients

    DEFF Research Database (Denmark)

    Pfeiffer, Helle Cecilie Viekilde; Løkkegaard, A; Zoetmulder, Marielle

    2013-01-01

    In Parkinson's disease (PD), Parkinson's disease dementia (PDD) and Parkinson's disease-mild cognitive impairment (PD-MCI) are common. PD-MCI is a risk factor for developing PDD. Knowledge of cognition in early-stages PD is essential in understanding and predicting the dementia process....

  2. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... People with Parkinson's? How Does Parkinson's Disease Affect Memory? OHSU - Therapeutic Approaches for PD: Depression, Anxiety & Psychosis ... to Parkinson's Disease Guide to Deep Brain Stimulation Sleep: A Mind Guide to Parkinson’s Disease Subscribe to ...

  3. Skin disorders in Parkinson's disease

    DEFF Research Database (Denmark)

    Ravn, Astrid-Helene; Thyssen, Jacob P; Egeberg, Alexander

    2017-01-01

    Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations...... with bullous pemphigoid. Moreover, a 2-fold increase in risk of new-onset PD has been observed in patients with rosacea. Besides the association between PD and various dermatological disorders, the skin may be useful in the diagnosis of PD. Early PD pathology is found not only in the brain but also in extra......-neuronal tissues. Thus, the protein α-synuclein, which is genetically associated with PD, is present not only in the CNS but also in the skin. Hence, higher values of α-synuclein have been observed in the skin of patients with PD. Furthermore, an increased risk of PD has been found in the Cys/Cys genotype, which...

  4. Experimental Study on Surge Propagation Characteristics of Rail and Lightning Overvoltages on Level Crossing

    Science.gov (United States)

    Arai, Hideki; Matsubara, Hiroji; Miyajima, Kiyotomi; Yokoyama, Shigeru; Sato, Kazutoshi

    Lightning protection measures are required for the railway signalling system because suspension and delays of trains due to lightnings may cause social confusion. Therefore, we carried out experiments on propagation characteristics of lightning surges along a rail, and injected a lightning surge current into the rail or wayside ground to raise their potentials, in order to measure the lightning overvoltages on a level crossing for the insulation design. There are no precedents that have carried out these experiments in the field until now. We could obtain the following results. (1) The surge impedance of the rail is 56Ω and the surge propagation velocity in the rail is 55m/μs. (2) The surge attenuation depends only on the duration of wave tail of the traveling lightning surge along the rail and decreases as the duration of wave tail becomes longer. (3) Flashovers may occur at the terminals in the equipment of the level crossing in case 1) a 2kA lightning surge current is directly injected into the rail, or 2) a 10kA lightning surge current is injected into the wayside ground at a vertical distance of 2m from the rail. (4) We can estimate the lightning overvoltages on the terminals in the equipment of the level crossing according to the vertical distance from the rail of the lighting stroke and the level of the stroke current.

  5. Storm surge in the Bay of Bengal and Arabian Sea: The problem and its prediction

    Digital Repository Service at National Institute of Oceanography (India)

    Dube, S.K.; Rao, A.D.; Sinha, P.C.; Murty, T.S.; Bahulayan, N.

    to annual economic losses in these countries. Thus, the real time monitoring and warning of storm surge is of great concern for this region. The goal of this paper is to provide an overview of major aspects of the storm surge problem in the Bay of Bengal...

  6. Artificial Neural Network forecasting of storm surge water levels at major estuarine ports to supplement national tide-surge models and improve port resilience planning

    Science.gov (United States)

    French, Jon; Mawdsley, Robert; Fujiyama, Taku; Achuthan, Kamal

    2017-04-01

    Effective prediction of tidal storm surge is of considerable importance for operators of major ports, since much of their infrastructure is necessarily located close to sea level. Storm surge inundation can damage critical elements of this infrastructure and significantly disrupt port operations and downstream supply chains. The risk of surge inundation is typically approached using extreme value analysis, while short-term forecasting generally relies on coastal shelf-scale tide and surge models. However, extreme value analysis does not provide information on the duration of a surge event and can be sensitive to the assumptions made and the historic data available. Also, whilst regional tide and surge models perform well along open coasts, their fairly coarse spatial resolution means that they do not always provide accurate predictions for estuarine ports. As part of a NERC Environmental Risks to Infrastructure Innovation Programme project, we have developed a tool that is specifically designed to forecast the North Sea storm surges on major ports along the east coast of the UK. Of particular interest is the Port of Immingham, Humber estuary, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. A tidal surge in December 2013, with an estimated return period of 760 years, partly flooded the port, damaged infrastructure and disrupted operations for several weeks. This and other recent surge events highlight the need for additional tools to supplement the national UK Storm Tide Warning Service. Port operators are also keen to have access to less computationally expensive forecasting tools for scenario planning and to improve their resilience to actual events. In this paper, we demonstrate the potential of machine learning methods based on Artificial Neural Networks (ANNs) to generate accurate short-term forecasts of extreme water levels at estuarine North Sea ports such as Immingham. An ANN is

  7. Condition Assessment of Metal Oxide Surge Arrester Based on Multi-Layer SVM Classifier

    Directory of Open Access Journals (Sweden)

    M Khodsuz

    2015-12-01

    Full Text Available This paper introduces the indicators for surge arrester condition assessment based on the leakage current analysis. Maximum amplitude of fundamental harmonic of the resistive leakage current, maximum amplitude of third harmonic of the resistive leakage current and maximum amplitude of fundamental harmonic of the capacitive leakage current were used as indicators for surge arrester condition monitoring. Also, the effects of operating voltage fluctuation, third harmonic of voltage, overvoltage and surge arrester aging on these indicators were studied. Then, obtained data are applied to the multi-layer support vector machine for recognizing of surge arrester conditions. Obtained results show that introduced indicators have the high ability for evaluation of surge arrester conditions.

  8. Local amplification of storm surge by Super Typhoon Haiyan in Leyte Gulf

    Science.gov (United States)

    Mori, Nobuhito; Kato, Masaya; Kim, Sooyoul; Mase, Hajime; Shibutani, Yoko; Takemi, Tetsuya; Tsuboki, Kazuhisa; Yasuda, Tomohiro

    2014-07-01

    Typhoon Haiyan, which struck the Philippines in November 2013, was an extremely intense tropical cyclone that had a catastrophic impact. The minimum central pressure of Typhoon Haiyan was 895 hPa, making it the strongest typhoon to make landfall on a major island in the western North Pacific Ocean. The characteristics of Typhoon Haiyan and its related storm surge are estimated by numerical experiments using numerical weather prediction models and a storm surge model. Based on the analysis of best hindcast results, the storm surge level was 5-6 m and local amplification of water surface elevation due to seiche was found to be significant inside Leyte Gulf. The numerical experiments show the coherent structure of the storm surge profile due to the specific bathymetry of Leyte Gulf and the Philippines Trench as a major contributor to the disaster in Tacloban. The numerical results also indicated the sensitivity of storm surge forecast.

  9. A Lightning Surge Analysis for the Rationalization of the Grounding System in Power Distribution Lines

    Science.gov (United States)

    Miyazaki, Teru; Okabe, Shigemitsu; Aiba, Kiyoshi; Hirai, Takao; Yoshinaga, Jun

    The grounding system is one of the most important lightning-protection features of power distribution lines. Based on the statistical distribution of surge currents through lightning arrestors caused by indirect lightning strokes and electrical surges in customers, a rated value of the grounding resistance for lightning arrestors on distribution lines was specified in the 1960's. TEPCO had conducted field research to measure the waveforms of surge voltage and current in order to rationalize the lightning protection design of distribution lines. And the authors proposed a lightning-surges analysis model based on the observation data. In this study, a lightning surge analysis for the rationalization of the grounding system was carried out by means of the EMTP. The calculation conditions were set based on the observation data. The calculated results suggest that a simple grounding design is possible. That can be useful for the Electric Power Companies to manage grounding systems.

  10. The reduction of storm surge by vegetation canopies: Three-dimensional simulations

    Science.gov (United States)

    Sheng, Y. Peter; Lapetina, Andrew; Ma, Gangfeng

    2012-10-01

    Significant buffering of storm surges by vegetation canopies has been suggested by limited observations and simple numerical studies, particularly following recent Hurricanes Katrina, Rita, and Wilma. Here we simulate storm surge and inundation over idealized topographies using a three-dimensional vegetation-resolving storm surge model coupled to a shallow water wave model and show that a sufficiently wide and tall vegetation canopy reduces inundation on land by 5 to 40 percent, depending upon various storm and canopy parameters. Effectiveness of the vegetation in dissipating storm surge and inundation depends on the intensity and forward speed of the hurricane, as well as the density, height, and width of the vegetation canopy. Reducing the threat to coastal vegetation from development, sea level rise, and other anthropogenic factors would help to protect many coastal regions against storm surges.

  11. Determining Storm Surge Return Periods: The Use of Evidence of Historic Events

    DEFF Research Database (Denmark)

    Madsen, Kristine S.; Sørensen, Carlo Sass; Schmith, Torben

    Storm surges are a major concern for many coastal communities, and rising levels of surges is a key concern in relation to climate change. The sea level of a statistical 100-year or 1000-year storm surge event and similar statistical measures are used for spatial planning and emergency preparedness....... These statistics are very sensitive to the assessments of past events, and to future sea level change. The probability of a major storm surge from the Baltic Sea hitting the Copenhagen metropolitan area is officially determined by the Danish Coastal Authority based on tide gauge records. We have a long history...... for tide gauge measurements, with 120 years of data available for the calculations. However, the oldest of these tide gauge stations was set up after a major storm surge in 1872, and no events of similar severity have occurred since. Including the evidence of the historic events from the 18th century...

  12. Parity nonconservation in 106Pd and 108Pd neutron resonances

    International Nuclear Information System (INIS)

    Crawford, B.E.; Roberson, N.R.; Bowman, J.D.; Knudson, J.N.; Penttilae, S.I.; Seestrom, S.J.; Yuan, V.W.; Delheij, P.P.; Haseyama, T.; Masaike, A.; Matsuda, Y.; Lowie, L.Y.; Mitchell, G.E.; Stephenson, S.L.; Postma, H.; Sharapov, E.I.

    1999-01-01

    Parity nonconservation (PNC) has been studied in the neutron p-wave resonances of 106 Pd and 108 Pd in the energy range of 20 to 2000 eV. Longitudinal asymmetries in p-wave capture cross sections are measured using longitudinally polarized neutrons incident on ∼20-g metal-powder targets at LANSCE. A CsI γ-ray detector array measures capture cross section asymmetries as a function of neutron energy which is determined by the neutron time-of-flight method. A total of 21 p-wave resonances in 106 Pd and 21 p-wave resonances in 108 Pd were studied. One statistically significant PNC effect was observed in 106 Pd, and no effects were observed in 108 Pd. For 106 Pd a weak spreading width of Γ w =34 -28 +47 x10 -7 eV was obtained. For 108 Pd an upper limit on the weak spreading width of Γ w -7 eV was determined at the 68% confidence level. copyright 1999 The American Physical Society

  13. Storm surge and wave simulations in the Gulf of Mexico using a consistent drag relation for atmospheric and storm surge models

    Directory of Open Access Journals (Sweden)

    D. Vatvani

    2012-07-01

    Full Text Available To simulate winds and water levels, numerical weather prediction (NWP and storm surge models generally use the traditional bulk relation for wind stress, which is characterized by a wind drag coefficient. A still commonly used drag coefficient in those models, some of them were developed in the past, is based on a relation, according to which the magnitude of the coefficient is either constant or increases monotonically with increasing surface wind speed (Bender, 2007; Kim et al., 2008; Kohno and Higaki, 2006. The NWP and surge models are often tuned independently from each other in order to obtain good results. Observations have indicated that the magnitude of the drag coefficient levels off at a wind speed of about 30 m s−1, and then decreases with further increase of the wind speed. Above a wind speed of approximately 30 m s−1, the stress above the air-sea interface starts to saturate. To represent the reducing and levelling off of the drag coefficient, the original Charnock drag formulation has been extended with a correction term.

    In line with the above, the Delft3D storm surge model is tested using both Charnock's and improved Makin's wind drag parameterization to evaluate the improvements on the storm surge model results, with and without inclusion of the wave effects. The effect of waves on storm surge is included by simultaneously simulating waves with the SWAN model on identical model grids in a coupled mode. However, the results presented here will focus on the storm surge results that include the wave effects.

    The runs were carried out in the Gulf of Mexico for Katrina and Ivan hurricane events. The storm surge model was initially forced with H*wind data (Powell et al., 2010 to test the effect of the Makin's wind drag parameterization on the storm surge model separately. The computed wind, water levels and waves are subsequently compared with observation data. Based on the good

  14. Genetic predisposition to Parkinson's disease

    DEFF Research Database (Denmark)

    Halling, Jónrit; Petersen, Maria Skaalum; Grandjean, Philippe

    2008-01-01

    OBJECTIVE: To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased. METHODS: Blood samples were collected from 79 PD patients and 154...

  15. The relationship between a blunted morning surge and a reversed nocturnal blood pressure dipping or "riser" pattern.

    Science.gov (United States)

    Fujiwara, Takeshi; Tomitani, Naoko; Sato, Keiko; Okura, Ayako; Suzuki, Noriyuki; Kario, Kazuomi

    2017-11-01

    The authors sought to determine the association between the blunted morning blood pressure (BP) surge and nocturnal BP dipping of the "riser" pattern in 501 patients with hypertension enrolled in the ACHIEVE-ONE (Ambulatory Blood Pressure Control and Home Blood Pressure [Morning and Evening] Lowering by the N-Channel Blocker Cilnidipine) trial. The patients' sleep-trough morning BP surge and prewaking surge were calculated and then classified according to their nocturnal systolic BP reduction pattern as extreme dippers, dippers, nondippers, and risers. The prevalence of the riser pattern was significantly higher in both the lowest sleep-trough morning BP surge decile and the prewaking surge decile (blunted surge group) compared with the remaining deciles (56.0% vs 10.4% [Pmorning BP surge (odds ratio, 73.3; Pmorning BP surges may account for the cardiovascular risk previously reported in such patients. ©2017 Wiley Periodicals, Inc.

  16. Representativeness of Honeypot Trial Participants to Australasian PD Patients.

    Science.gov (United States)

    Zhang, Lei; Badve, Sunil V; Pascoe, Elaine M; Beller, Elaine; Cass, Alan; Clark, Carolyn; de Zoysa, Janak; Isbel, Nicole M; Liu, Xusheng; McTaggart, Steven; Morrish, Alicia T; Playford, Geoffrey; Scaria, Anish; Snelling, Paul; Vergara, Liza A; Hawley, Carmel M; Johnson, David W

    2017-01-01

    The HONEYPOT trial failed to establish the superiority of exit-site application of Medihoney compared with nasal mupirocin prophylaxis for the prevention of peritonitis in peritoneal dialysis (PD) patients. This study aimed to assess the representativeness of the patients in the HONEYPOT trial to the Australian and New Zealand PD population. This study compared baseline characteristics of the 371 PD patients in the HONEYPOT trial with those of 6,085 PD patients recorded on the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Compared with the PD population, the HONEYPOT sample was older (standardized difference [ d ] = 0.19, p = 0.003), more likely to be treated with automated PD ( d = 0.58, p < 0.001), had higher residual renal function ( d = 0.26, p < 0.001) and a higher proportion of participants with end-stage kidney disease due to polycystic kidney disease ( d = 0.17) and lower proportion due to diabetes ( d = -0.17) and glomerulonephritis ( d = -0.18) ( p < 0.001), and lower proportions of indigenous people ( d = -0.17, p < 0.001), current smokers ( d = -0.10, p < 0.001), and people with prior histories of hemodialysis ( d = -0.16, p < 0.001), diabetes mellitus ( d = -0.18, p < 0.001), and coronary artery disease ( d = -0.15, p < 0.001). HONEYPOT trial participants tended to be healthier than the Australian and New Zealand PD patient population. Although the differences between the groups were generally modest, it is possible that their cumulative effect may have had some impact on external generalizability, which is not an uncommon occurrence in clinical trials. Copyright © 2017 International Society for Peritoneal Dialysis.

  17. Storm surges in the White and Barents Seas: formation, statistics, analysis

    Science.gov (United States)

    Korablina, Anastasia; Arkhipkin, Victor

    2017-04-01

    Arctic seas storm surges investigation are high priority in Russia due to the active development of offshore oil and gas, construction of facilities in the coastal zone, as well as for the navigation safety. It is important to study the surges variability, to predict this phenomena and subsequent economic losses, thus including such information into the Russian Arctic Development Program 2020. White and Barents Seas storm surges are caused mainly by deep cyclones of two types: "diving" from the north (88% of all cyclones) and Atlantic from the west. The surge height was defined as the excess of the level that was obtained as the difference between the observed level and subtracting tide level and low-frequency level. The period of low-frequency level oscillation was determined by spectral analysis of the in-situ data. ADCIRC model is used for calculating the storm surge height. We did the calculations on unstructured grid with variable step from 50 to 5000 m. The ADCIRC model was based on the data on wind field, the sea level pressure, the concentration of ice reanalysis CFSR (1979-2010) in increments 0.3°, CFSv2 (2011-2015) in increments 0.2°. On the boundary conditions harmonic constants from Finite Element Solution tide model 2004 (FES2004) in increments 1/8° were set. The following stations on the coast Varandey, Pechora Bay, Chosha Bay, Severodvinsk, Onega, Solovki and other were selected for the storm surges statistical analysis in the period 1979-2015. The number of storm surges (> 0.3 m) long-term variability was obtained, the number of surges at a height (m) range (0.3-0.6, 0.6-0.9, 0.9-1.2, >1.2) was estimated. It shows that 1980 and 1998 are the years with the fewest number storms. For example, the largest number of storm surge (53) was observed in 1995 in Varandey. The height of the surge, possible only once in 100 years, is counted. This maximum height (m) of the surge was noted in Varandey (4.1), Chosha Bay (3.4), Barents Sea, Onega Bay (2

  18. Emotional impairment in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    CHEN Hai-bo

    2013-08-01

    Full Text Available Emotional impairment is the common complication of Parkinson's disease (PD. Depression, anxiety and apathy affect the quality of life and the prognosis of PD patients. Neuropsychological and neuroimaging studies of emotional impairment in PD patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways, but the specific mechanism needs further study. In this review we discuss the clinical manifestation, possible pathological mechanism, diagnosis and treatment in PD patients.

  19. Evidence for Anti-Pseudogymnoascus destructans (Pd Activity of Propolis

    Directory of Open Access Journals (Sweden)

    Soumya Ghosh

    2017-12-01

    Full Text Available White-nose syndrome (WNS in bats, caused by Pseudogymnoascus destructans (Pd, is a cutaneous infection that has devastated North American bat populations since 2007. At present, there is no effective method for controlling this disease. Here, we evaluated the effect of propolis against Pd in vitro. Using Sabouraud dextrose agar (SDA medium, approximately 1.7 × 107 conidia spores of the Pd strain M3906-2/mL were spread on each plate and grown to form a consistent lawn. A Kirby–Bauer disk diffusion assay was employed using different concentrations of propolis (1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25%, in plates incubated at 8 °C and 15 °C. At 8 °C and 15 °C, as the concentration of propolis increased, there was an increasing zone of inhibition (ZOI, reaching the highest degree at 10% and 25% concentrations, respectively. A germule suppression assay showed a similar effect on Pd conidia germination. A MALDI-TOF-MS analysis of propolis revealed multiple constituents with a potential anti-Pd activity, including cinnamic acid, p-coumaric acid, and dihydrochalcones, which could be further tested for their individual effects. Our study suggests that propolis or its individual constituents might be suitable products against Pd.

  20. Modelling the 2013 Typhoon Haiyan Storm Surge: Effect of Waves, Offshore Winds, Tide Phase, and Translation Speed

    Science.gov (United States)

    Bilgera, P. H. T.; Villanoy, C.; Cabrera, O.

    2016-02-01

    Super Typhoon Haiyan, with wind speeds exceeding 300 km h-1 (160 knots) generated a storm surge in San Pedro Bay reaching heights of more than 6m in Tacloban City. Delft Dashboard (DDB), an open-source standalone Matlab based graphical user interface linked to the FLOW and WAVE modeling software of Deltares, was used to develop a coupled flow and wave storm surge model to understand the Typhoon Haiyan storm surge development and propagation. Various experiments were designed to determine the effect of waves, the occurrence of offshore winds prior to the surge, tidal phase, and typhoon translation speed on the surge height. Wave coupling decreased the surge height by about 0.5m probably due to energy dissipation from white capping, bottom friction, and depth-induced breaking. Offshore-directed winds before the arrival of the storm eye resulted to receding of the water level in San Pedro and Cancabato Bay, corroborated by eyewitness and tide gauge data. The experiment wherein the offshore winds were removed resulted to no water receding and a surge with a smaller and gentler surge front, pointing to the importance of the initial water level drawdown in contributing to the destructive power of the wave front. With regard to tides, the effect in Tacloban was actually neither linear nor additive to the surge, with higher surge coincident to low tides and lower surge coincident to high tides. Lastly, the model run with typhoon having a slower translation speed than Haiyan was found to generate higher surges.

  1. Imaging the impact of genes on Parkinson's disease

    DEFF Research Database (Denmark)

    van der Vegt, J P M; van Nuenen, B F L; Bloem, B R

    2009-01-01

    Although Parkinson's disease (PD) has traditionally been considered to be a non-genetic disorder, recent progress in the neurogenetics of PD provided converging evidence that genetic factors play a relevant role in the etiology of PD. The strongest case for a genetic contribution to PD was made...... of individuals carrying a mutation in one of the PD genes has offered a unique avenue of research into the pathogenesis of PD. In symptomatic mutation carriers (i.e. those with overt disease), brain mapping can help to link the molecular pathogenesis of PD more directly with functional and structural changes...

  2. Predicting Typhoon Induced Storm Surges Using the Operational Ocean Forecast System

    Directory of Open Access Journals (Sweden)

    Sung Hyup You

    2010-01-01

    Full Text Available This study was performed to compare storm surges simulated by the operational storm surges/tide forecast system (STORM : Storm surges/Tide Operational Model of the Korea Meteorological Administration (KMA with observations from 30 coastal tidal stations during nine typhoons that occurred between 2005 and 2007. The results (bias showed that for cases of overestimation (or underestimation, storm surges tended to be overestimated (as well as underestimated at all coastal stations. The maximum positive bias was approximately 6.92 cm for Typhoon Ewiniar (2006, while the maximum negative bias was approximately -12.06 cm for Typhoon Khanun (2005. The maximum and minimum root mean square errors (RMSEs were 14.61 and 6.78 cm, which occurred for Typhoons Khanun (2005 and Usagi (2007, respectively. For all nine typhoons, total averaged RMSE was approximately 10.2 cm. Large differences between modeled and observed storm surges occurred in two cases. In the first, a very weak typhoon, such as Typhoon Khanun (2005, caused low storm surges. In the other, exemplified by Typhoon Nari (2007, there were errors in the predicted typhoon strength used as input data for the storm surge model.

  3. Cold Surge Activity Over the Gulf of Mexico in a Warmer Climate

    Directory of Open Access Journals (Sweden)

    Edgar Perez Perez

    2014-08-01

    Full Text Available Cold surges are a dominant feature of midlatitude tropical interaction. During the North Hemisphere (NH winter, midlatitude waves propagating from the Rocky Mountains into the Gulf of Mexico result in cold surges, also known as Nortes or Tehuantepecers, associated with severe weather over the southern part of Mexico. The magnitude of their intense surface winds, precipitation and drops in surface temperature depends on the characteristics of the midlatitude wave propagating into the tropics. The high spatial resolution (20km X 20km version of the TL959L60-AGC Model of the Meteorological Research Institute of Japan is used to examine changes in cold surge activity under the A1B greenhouse gas emission scenario for the 2080 - 2099 period. The model realistically reproduces the spatial and temporal characteristics of cold surges for the 1980 - 1989 control period. The effect of changes in baroclinicity, static stability and mean flow over North America suggest that in a warmer climate, increased cold surge activity over the Gulf of Mexico would occur. However, these systems would have shorter wavelength (higher phase speeds and shorter lifespans that could reduce the total amount of winter precipitation. The increased frequency of cold surges over the Gulf of Mexico would be a consequence of weaker baroclinicity and static stability in the lower troposphere over the cold surge genesis region, along with more dominant westerly winds, resulting from ENSO-like conditions in the atmospheric circulations over North America.

  4. Reflection and dampening of pressure waves in marine terminal pressure surge analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kossatz, Helmut [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil); Ladeia, Renata C. da Cunha [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil). Dept. de Engenharia Mecanica. Nucleo de Simulacao Termohidraulica de Dutos (SIMDUT)

    2005-07-01

    In the analysis of potential surge pressure hazards in marine terminals, the piping system connecting the terminal's tank farm to the oil tanker is commonly composed of a main pipeline ending in reduced diameter devices of relatively short length such as loading arms or cargo hoses, and pressure surges may be generated due sudden closure of the oil tanker's emergency shut down valves, or from closure of valves in quick breakaway couplings. Since velocities in these smaller diameter sections are much higher than in the main pipeline, local pressure peaks may occur which are greater than the surge pressure generated due to flow stoppage in the larger diameter pipe. These local pressure pulses are rapidly damped out due to reflection at the connection with the larger diameter pipeline and are simultaneously transmitted and superposed on the pressure surge generated in the main pipeline. Cargo hoses are more elastic with much lower acoustic speed than in steel pipe, and local pressure surges are therefore smaller than in an equivalent section of steel pipeline. Nevertheless local surge pressures are still capable of being greater than in the main steel pipeline due to higher initial flow velocities. This work analyses these effects and points out the care to be taken in pressure surge simulation in order to obtain reliable results. (author)

  5. Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease: a large pragmatic randomised controlled trial (PD REHAB).

    Science.gov (United States)

    Clarke, Carl E; Patel, Smitaa; Ives, Natalie; Rick, Caroline E; Woolley, Rebecca; Wheatley, Keith; Walker, Marion F; Zhu, Shihua; Kandiyali, Rebecca; Yao, Guiqing; Sackley, Catherine M

    2016-08-01

    Cochrane reviews of physiotherapy (PT) and occupational therapy (OT) for Parkinson's disease found insufficient evidence of effectiveness, but previous trials were methodologically flawed with small sample size and short-term follow-up. To evaluate the clinical effectiveness and cost-effectiveness of individualised PT and OT in Parkinson's disease. Large pragmatic randomised controlled trial. Thirty-eight neurology and geriatric medicine outpatient clinics in the UK. Seven hundred and sixty-two patients with mild to moderate Parkinson's disease reporting limitations in activities of daily living (ADL). Patients were randomised online to either both PT and OT NHS services (n = 381) or no therapy (n = 381). Therapy incorporated a patient-centred approach with individual assessment and goal setting. The primary outcome was instrumental ADL measured by the patient-completed Nottingham Extended Activities of Daily Living (NEADL) scale at 3 months after randomisation. Secondary outcomes were health-related quality of life [Parkinson's Disease Questionnaire-39 (PDQ-39); European Quality of Life-5 Dimensions (EQ-5D)], adverse events, resource use and carer quality of life (Short Form questionnaire-12 items). Outcomes were assessed before randomisation and at 3, 9 and 15 months after randomisation. Data from 92% of the participants in each group were available at the primary time point of 3 months, but there was no difference in NEADL total score [difference 0.5 points, 95% confidence interval (CI) -0.7 to 1.7; p = 0.4] or PDQ-39 summary index (0.007 points, 95% CI -1.5 to 1.5; p = 1.0) between groups. The EQ-5D quotient was of borderline significance in favour of therapy (-0.03, 95% CI -0.07 to -0.002; p = 0.04). Contact time with therapists was for a median of four visits of 58 minutes each over 8 weeks (mean dose 232 minutes). Repeated measures analysis including all time points showed no difference in NEADL total score, but PDQ-39 summary index

  6. Switching surge overvoltages on a feeding system of a MAGLEV train; Jiki fujoshiki tetsudo no kidenkei ni okeru kaihei surge kaden`atsu

    Energy Technology Data Exchange (ETDEWEB)

    Muragishi, H. [Nippon Yusoki Co. Ltd., Kyoto (Japan); Nakamura, Y.; Muraoka, N.; Ametani, A. [Doshisha Univ., Kyoto (Japan)

    1997-04-20

    Discussions using simulations were given on surge overvoltages and earth fault surge overvoltage associated with operation of a section switchgear in a feeding system of a MAGLEV train. Results of the discussions may be summarized as follows: throw-in surge overvoltage caused by the section switchgear is about 25 kV at maximum on the coil and about 15 kV on the cable sheath. The coil overvoltage increases as the closer to 90 degrees the throw-in phase approaches, and the greater the power supply frequency increases. The cable sheath overvoltage, however, is not affected by these environments. Breaking surge overvoltage caused by the section switchgear reaches 115 kV on the coil and about the same value on the cable sheath when the breaking current is 50 A. Earth fault surge overvoltage due to cable fault is 24 kV at maximum on the coil, while it reaches 32 kV on the cable sheath. The cable sheath overvoltage depends largely on sheath installing conditions. These overvoltages can be suppressed sufficiently lower than insulation levels of each device by installing arresters. 17 refs., 18 figs.

  7. Identification of storm surge events over the German Bight from atmospheric reanalysis and climate model data

    Science.gov (United States)

    Befort, D. J.; Fischer, M.; Leckebusch, G. C.; Ulbrich, U.; Ganske, A.; Rosenhagen, G.; Heinrich, H.

    2015-06-01

    A new procedure for the identification of storm surge situations for the German Bight is developed and applied to reanalysis and global climate model data. This method is based on the empirical approach for estimating storm surge heights using information about wind speed and wind direction. Here, we hypothesize that storm surge events are caused by high wind speeds from north-westerly direction in combination with a large-scale wind storm event affecting the North Sea region. The method is calibrated for ERA-40 data, using the data from the storm surge atlas for Cuxhaven. It is shown that using information of both wind speed and direction as well as large-scale wind storm events improves the identification of storm surge events. To estimate possible future changes of potential storm surge events, we apply the new identification approach to an ensemble of three transient climate change simulations performed with the ECHAM5/MPIOM model under A1B greenhouse gas scenario forcing. We find an increase in the total number of potential storm surge events of about 12 % [(2001-2100)-(1901-2000)], mainly based on changes of moderate events. Yearly numbers of storm surge relevant events show high interannual and decadal variability and only one of three simulations shows a statistical significant increase in the yearly number of potential storm surge events between 1900 and 2100. However, no changes in the maximum intensity and duration of all potential events is determined. Extreme value statistic analysis confirms no frequency change of the most severe events.

  8. Slab entrainment and surge dynamics of the 2015 Valleé de la Sionne avalanches

    Science.gov (United States)

    Köhler, Anselm; McElwaine, Jim; Sovilla, Betty

    2016-04-01

    On 3 February 2015 five avalanches were artificially released at the Valleé de la Sionne test site in the west of Switzerland. The dense parts of the avalanches were tracked by the GEODAR Mark 2 radar system at 111 Hz framerate with 0.75 m down slope resolution. The data show that these avalanche contain several internal surges and that the avalanche front is repeatedly overtaken by some of these surges. We show that these surges exist on different scale. While the major surges originates from secondary triggered slab releases and occur all over the avalanche. The minor surges are only found in the energetic part of a well developed powder snow avalanche. The mass of the major surges can be as huge as the initial released mass, this has a dramatic effect on the mass distribution inside the avalanche and effects the front velocity and run out. Furthermore, the secondary released snow slabs are an important entrainment mechanism and up to 50 percent of the mass entered the avalanche via slab entrainment. We analyse the dynamics of the leading edge and the minor surges in more detail using a simple one dimensional model with frictional resistance and quadratic velocity dependent drag. These models fit the data well for the start and middle of avalanche but cannot capture the slowing and overtaking of the minor surge. We find much higher friction coefficients to describe the surging. We propose that this data can only be explained by changes in the snow surface. These effects are not included in current models yet, but the data presented here will enable the development and verification of such models.

  9. The impact of climate change on storm surges over Irish waters

    Science.gov (United States)

    Wang, Shiyu; McGrath, Ray; Hanafin, Jenny; Lynch, Peter; Semmler, Tido; Nolan, Paul

    The Regional Ocean Model System (ROMS) of Rutgers University is used to investigate the influence of anthropogenic climate change on storm surges over Irish waters, particularly on the extreme values. Two experiments were performed to confirm the validity of the approach in the current climate: the first focused on hindcasting the surge generated by a storm in early 2002 while the second provided surge statistics by running the model for the period 1990-2002; in both cases ROMS was driven with ERA-40 forcing fields. The results show that the model is capable of simulating both specific surge events and surge climate statistics with reasonable accuracy (order of 10 cm). Model outputs were also compared spatially against satellite altimetry data, corrected for long wavelength errors, from 1993 to 2001. The ROMS model consistently reproduces the sea level changes in the Irish Sea, and over the waters to the south and west of Ireland. For the investigation of the impact of the climate change on storm surges, the same configuration of ROMS was driven by atmospheric forcing fields downscaled from ECHAM5/OM1 data for the past (1961-1990) and future (2031-2060; SRES A1B greenhouse gas scenario); the downscaled data were produced using the Rossby Centre Regional Atmosphere model (RCA3). The results show an increase in storm surge events around Irish coastal areas in the future projection, except along the south Irish coast; there is also a significant increase in the height of the extreme surges along the west and east coasts, with most of the extreme surges occurring in wintertime.

  10. Smart Ultrasound Remote Guidance Experiment (SURGE) Preliminary Findings

    Science.gov (United States)

    Hurst, Victor; Dulchavsky, Scott; Garcia, Kathleen; Sargsyan, Ashot; Ebert, Doug

    2009-01-01

    To date, diagnostic quality ultrasound images were obtained aboard the International Space Station (ISS) using the ultrasound of the Human Research Facility (HRF) rack in the Laboratory module. Through the Advanced Diagnostic Ultrasound in Microgravity (ADUM) and the Braslet-M Occlusion Cuffs (BRASLET SDTO) studies, non-expert ultrasound operators aboard the ISS have performed cardiac, thoracic, abdominal, vascular, ocular, and musculoskeletal ultrasound assessments using remote guidance from ground-based ultrasound experts. With exploration class missions to the lunar and Martian surfaces on the horizon, crew medical officers will necessarily need to operate with greater autonomy given communication delays (round trip times of up to 5 seconds for the Moon and 90 minutes for Mars) and longer periods of communication blackouts (due to orbital constraints of communication assets). The SURGE project explored the feasibility and training requirements of having non-expert ultrasound operators perform autonomous ultrasound assessments in a simulated exploration mission outpost. The project aimed to identify experience, training, and human factors requirements for crew medical officers to perform autonomous ultrasonography. All of these aims pertained to the following risks from the NASA Bioastronautics Road Map: 1) Risk 18: Major Illness and Trauna; 2) Risk 20) Ambulatory Care; 3) Risk 22: Medical Informatics, Technologies, and Support Systems; and 4) Risk 23: Medical Skill Training and Maintenance.

  11. Magnitude of Morning Surge in Blood Pressure Is Associated with Sympathetic but Not Cardiac Baroreflex Sensitivity.

    Science.gov (United States)

    Johnson, Aaron W; Hissen, Sarah L; Macefield, Vaughan G; Brown, Rachael; Taylor, Chloe E

    2016-01-01

    The ability of the arterial baroreflex to regulate blood pressure may influence the magnitude of the morning surge in blood pressure (MSBP). The aim was to investigate the relationships between sympathetic and cardiac baroreflex sensitivity (BRS) and the morning surge. Twenty-four hour ambulatory blood pressure was recorded in 14 young individuals. The morning surge was defined via the pre-awakening method, which is calculated as the difference between mean blood pressure values 2 h before and 2 h after rising from sleep. The mean systolic morning surge, diastolic morning surge, and morning surge in mean arterial pressures were 15 ± 2, 13 ± 1, and 11 ± 1 mmHg, respectively. During the laboratory protocol, continuous measurements of blood pressure, heart rate, and muscle sympathetic nerve activity (MSNA) were made over a 10-min period of rest. Sympathetic BRS was quantified by plotting MSNA burst incidence against diastolic pressure (sympathetic BRSinc), and by plotting total MSNA against diastolic pressure (sympathetic BRStotal). Cardiac BRS was quantified using the sequence method. The mean values for sympathetic BRSinc, sympathetic BRStotal and cardiac BRS were -1.26 ± 0.26 bursts/100 hb/mmHg, -1.60 ± 0.37 AU/beat/mmHg, and 13.1 ± 1.5 ms/mmHg respectively. Significant relationships were identified between sympathetic BRSinc and the diastolic morning surge (r = 0.62, p = 0.02) and the morning surge in mean arterial pressure (r = 0.57, p = 0.03). Low sympathetic BRS was associated with a larger morning surge in mean arterial and diastolic blood pressure. Trends for relationships were identified between sympathetic BRStotal and the diastolic morning surge (r = 0.52, p = 0.066) and the morning surge in mean arterial pressure (r = 0.48, p = 0.095) but these did not reach significance. There were no significant relationships between cardiac BRS and the morning surge. These findings indicate that the ability of the baroreflex to buffer increases in blood pressure

  12. The Xylella fastidiosa PD1063 protein is secreted in association with outer membrane vesicles.

    Science.gov (United States)

    Pierce, Brittany K; Voegel, Tanja; Kirkpatrick, Bruce C

    2014-01-01

    Xylella fastidiosa is a gram-negative, xylem-limited plant pathogenic bacterium that causes disease in a variety of economically important agricultural crops including Pierce's disease of grapevines. Xylella fastidiosa biofilms formed in the xylem vessels of plants play a key role in early colonization and pathogenicity by providing a protected niche and enhanced cell survival. Here we investigate the role of Xylella fastidiosa PD1063, the predicted ortholog of Xanthomonas oryzae pv. oryzae PXO_03968, which encodes an outer membrane protein. To assess the function of the Xylella fastidiosa ortholog, we created Xylella fastidiosa mutants deleted for PD1063 and then assessed biofilm formation, cell-cell aggregation and cell growth in vitro. We also assessed disease severity and pathogen titers in grapevines mechanically inoculated with the Xylella fastidiosa PD1063 mutant. We found a significant decrease in cell-cell aggregation among PD1063 mutants but no differences in cell growth, biofilm formation, disease severity or titers in planta. Based on the demonstration that Xanthomonas oryzae pv. oryzae PXO_03968 encodes an outer membrane protein, secreted in association with outer membrane vesicles, we predicted that PD1063 would also be secreted in a similar manner. Using anti-PD1063 antibodies, we found PD1063 in the supernatant and secreted in association with outer membrane vesicles. PD1063 purified from the supernatant, outer membrane fractions and outer membrane vesicles was 19.2 kD, corresponding to the predicted size of the processed protein. Our findings suggest Xylella fastidiosa PD1063 is not essential for development of Pierce's disease in Vitis vinifera grapevines although further research is required to determine the function of the PD1063 outer membrane protein in Xylella fastidiosa.

  13. Preparation of TiO₂ supported Au–Pd and Cu–Pd by the combined ...

    Indian Academy of Sciences (India)

    TiO₂ supported Au–Pd and Cu–Pd catalysts were prepared by strong electrostatic adsorption (SEA) of Pd followed by electroless deposition (ED) of a second metal with incremental surface coverages of Au or Cu. High dispersion of small Pd particles on the Pd/TiO2 prepared by SEA led to the high amount of second metal ...

  14. Preparation of supported Au–Pd and Cu–Pd by the combined strong ...

    Indian Academy of Sciences (India)

    BOONTIDA PONGTHAWORNSAKUN

    2017-10-25

    Oct 25, 2017 ... Abstract. TiO2 supported Au–Pd and Cu–Pd catalysts were prepared by strong electrostatic adsorption (SEA) of Pd followed by electroless deposition (ED) of a second metal with incremental surface coverages of Au or. Cu. High dispersion of small Pd particles on the Pd/TiO2 prepared by SEA led to the ...

  15. Magnetotransport in Pd-rich PdFe alloys

    Czech Academy of Sciences Publication Activity Database

    Kudrnovský, Josef; Drchal, Václav; Turek, Ilja

    2013-01-01

    Roč. 26, č. 5 (2013), s. 1749-1752 ISSN 1557-1939 R&D Projects: GA ČR(CZ) GAP204/11/1228 Institutional support: RVO:68378271 ; RVO:68081723 Keywords : galvanomagnetic transport * Pd-rich PdFe * long-range order * effect of temperature * anisotropic magnetoresistance Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.930, year: 2013

  16. Neuronal oscillations in Parkinson's disease.

    Science.gov (United States)

    Witcher, Mark; Moran, Rosalyn; Tatter, Stephen B; Laxton, Adrian W

    2014-06-01

    Parkinson's Disease (PD), characterized by tremor, rigidity, and bradykinesia, is one of the most prevalent neurodegenerative disorders in the world. The pathological hallmark of PD is the loss of dopaminergic cells in the substantia nigra and other brain regions. The pathophysiological mechanisms by which dopaminergic cell loss leads to the motor manifestations of PD are yet to be fully elucidated. A growing body of evidence has revealed abnormal neuronal oscillations within and between multiple brain regions in PD. Unique oscillatory patterns are associated with specific motor abnormalities in PD. Therapies, such as dopaminergic medication and deep brain stimulation that disrupt these abnormal neuronal oscillatory patterns produce symptomatic improvement in PD patients. These findings emphasize the importance of abnormal neuronal oscillations in the pathophysiology of PD, making the disruption of these oscillatory patterns a promising target in the development of effective PD treatments.

  17. Growth of Pd{sub 4}S, PdS and PdS{sub 2} films by controlled sulfurization of sputtered Pd on native oxide of Si

    Energy Technology Data Exchange (ETDEWEB)

    Bhatt, R., E-mail: rbhatt@barc.gov.in [Technical Physics Division, Bhabha Atomic Research Center, Mumbai–400 085 (India); Bhattacharya, S.; Basu, R.; Singh, A. [Technical Physics Division, Bhabha Atomic Research Center, Mumbai–400 085 (India); Deshpande, U. [UGC–DAE Consortium for Scientific Research, University Campus, Khandwa Road, Indore–452017 (India); Surger, C. [Karlsruhe Institute of Technology, Physikalisches Institut and DFG Center for Functional Nanostructures, P.O. Box 6980, D–76049 Karlsruhe (Germany); Basu, S. [Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai-400 085 (India); Aswal, D.K.; Gupta, S.K. [Technical Physics Division, Bhabha Atomic Research Center, Mumbai–400 085 (India)

    2013-07-31

    Thin films of different Pd–S phase, namely Pd{sub 4}S, PdS and PdS{sub 2}, have been reproducibly grown by the sulfurization of Pd films deposited on native oxide of (111) Si substrates by radio frequency sputtering method. In order to achieve controlled sulfurization, a three-stage sulfurization setup consisting of evaporation chamber, activation chamber and sulfurization chamber has been developed. The sulfurization of Pd films (kept at a constant temperature of 500 °C) was carried out using sulfur vapors activated to different temperature between 550 and 700 °C. The results of X-ray diffraction and X-ray photoelectron spectroscopy measurements show that formation of Pd{sub 4}S, PdS and PdS{sub 2} phases takes place for the activation temperatures of 550, 600 and 700 °C, respectively. The room temperature resistivity of Pd, Pd{sub 4}S, PdS and PdS{sub 2} were found to be respectively 0.1, 15.9, 15,000 and 20,000 μΩ cm. The temperature-dependent electrical resistivity measurements showed metallic conduction for Pd and Pd{sub 4}S films. The Seebeck coefficient measured at 300 K for these Pd–S phases showed their n-type conducting behavior. - Highlights: • Multichamber sulfurization setup designed for preparing thin films of Pd–S. • S vapor activated at 550, 600 and 700 °C results in Pd{sub 4}S, PdS and PdS{sub 2} phases. • The Seebeck coefficient of Pd–S phases shows their n-type conducting behavior. • Transport properties of Pd{sub 4}S phase show that it is a metallic phase. • High resistivity and thermopower of PdS and PdS{sub 2} show semiconducting nature.

  18. Real-Time Forecasting System of Winds, Waves and Surge in Tropical Cyclones

    National Research Council Canada - National Science Library

    Graber, Hans C; Donelan, Mark A; Brown, Michael G; Slinn, Donald N; Hagen, Scott C; Thompson, Donald R; Jensen, Robert E; Black, Peter G; Powell, Mark D; Guiney, John L; Cardone, Vincent J; Cox, Andrew T; Augustus, Ellsworth H; Colonnese, Christopher P

    2003-01-01

    The long-term goal of this partnership is to establish an operational forecasting system of the wind field and resulting waves and surge impacting the coastline during the approach and landfall of tropical cyclones...

  19. Sea, Lake, and Overland Surge from Hurricanes (SLOSH) Inundation for Categories 2 and 4

    Data.gov (United States)

    U.S. Environmental Protection Agency — The file geodatabase (fgdb) contains the Sea, Lake, and Overland Surge from Hurricanes (SLOSH) Maximum of Maximums (MOM) model for hurricane categories 2 and 4. The...

  20. Real-Time Forecasting System of Winds, Waves and Surge in Tropical Cyclones

    National Research Council Canada - National Science Library

    Graber, Hans C; Donelan, Mark A; Brown, Michael G; Slinn, Donald N; Hagen, Scott C; Thompson, Donald R; Jensen, Robert E; Black, Peter G; Powell, Mark D; Guiney, John L

    2004-01-01

    The long-term goal of this partnership is to establish an operational forecasting system of the wind field and resulting waves and surge impacting the coastline during the approach and landfall of tropical cyclones...

  1. Real-Time Forecasting System of Winds, Waves and Surge in Tropical Cyclones

    National Research Council Canada - National Science Library

    Graber, Hans C; Donelan, Mark A; Brown, Michael G; Slinn, Donald N; Hagen, Scott C; Thompson, Donald R; Jensen, Robert E; Black, Peter G; Powell, Mark D; Guiney, John L

    2005-01-01

    The long-term goal of this partnership is to establish an operational forecasting system of the wind field and resulting waves and surge impacting the coastline during the approach and landfall of tropical cyclones...

  2. Efficiency and safety of percuSurge distal protection device in acute ...

    African Journals Online (AJOL)

    Efficiency and safety of percuSurge distal protection device in acute myocardial infarction during emergent percutaneous coronary intervention treatment. XY Feng, HT Liu, Y Gao, X Gua, RF Xu, HC Wang, CX Li ...

  3. Criteria for the Identification of Pyroclastic Surge Deposits on Mars: Insight from Hunt's Hole, New Mexico

    Science.gov (United States)

    Edgar, L. A.; Grotzinger, J. P.; Southard, J. B.; Ewing, R. C.; Lamb, M. P.

    2012-03-01

    We combine field observations, Terrestrial Laser Scanning (TLS), and hydrodynamic considerations to understand pyroclastic surge deposits at Hunt’s Hole, New Mexico, and provide criteria for their identification on Mars.

  4. Evaluation of Ferrite Chip Beads as Surge Current Limiters in Circuits with Tantalum Capacitors

    Science.gov (United States)

    Teverovsky, Alexander

    2014-01-01

    Limiting resistors are currently required to be connected in series with tantalum capacitors to reduce the risk of surge current failures. However, application of limiting resistors decreases substantially the efficiency of the power supply systems. An ideal surge current limiting device should have a negligible resistance for DC currents and high resistance at frequencies corresponding to transients in tantalum capacitors. This work evaluates the possibility of using chip ferrite beads (FB) as such devices. Twelve types of small size FBs from three manufacturers were used to evaluate their robustness under soldering stresses and at high surge current spikes associated with transients in tantalum capacitors. Results show that FBs are capable to withstand current pulses that are substantially greater than the specified current limits. However, due to a sharp decrease of impedance with current, FBs do not reduce surge currents to the required level that can be achieved with regular resistors.

  5. Control of Surge in Centrifugal Compressors by Active Magnetic Bearings Theory and Implementation

    CERN Document Server

    Yoon, Se Young; Allaire, Paul E

    2013-01-01

    Control of Surge in Centrifugal Compressors by Active Magnetic Bearings sets out the fundamentals of integrating the active magnetic bearing (AMB) rotor suspension technology in compressor systems, and describes how this relatively new bearing technology can be employed in the active control of compressor surge. The authors provide a self-contained and comprehensive review of rotordynamics and the fundamentals of the AMB technology. The active stabilization of compressor surge employing AMBs in a machine is fully explored, from the modeling of the instability and the design of feedback controllers, to the implementation and experimental testing of the control algorithms in a specially-constructed, industrial-size centrifugal compression system. The results of these tests demonstrate the great potential of the new surge control method developed in this text. This book will be useful for engineers in industries that involve turbocompressors and magnetic bearings, as well as for researchers and graduate students...

  6. On the Storm Surge and Sea Level Rise Projections for Infrastructure Risk Analysis and Adaptation

    Science.gov (United States)

    Storm surge can cause coastal hydrology changes, flooding, water quality changes, and even inundation of low-lying terrain. Strong wave actions and disruptive winds can damage water infrastructure and other environmental assets (hazardous and solid waste management facilities, w...

  7. Study of a Novel Oscillating Surge Wave Energy Converter: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Tom, Nathan M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Choiniere, Michael [University of Maine; Thiagarajan, Krish P. [University of Maine

    2017-08-01

    This study investigates the performance of an oscillating surge wave energy converter (OSWEC) that utilizes adjustable geometry as a means of controlling the hydrodynamic coefficients, a concept originally proposed by [1]. The body of the device consists of a bottom-hinged solid rectangular frame with five horizontal flaps spanning the interior of the frame. The flaps can rotate independently about their center of rotation within the frame like a large window shutter. Changing the orientation of the flaps alters the hydrodynamic coefficients and natural frequency of the device as well as the ability to shed or absorb structural loads accordingly. This ability may allow the device to operate in a wider range of sea states than other current wave energy converter designs. This paper presents and compares the results of numerical simulations and experimental testing of the OSWEC's response to regular waves with all five of the horizontal fin configurations sharing the same orientation of 0 degrees (fully closed interior) and 90 degrees (fully open). The numerical simulations were performed using WAMIT, which calculates hydrodynamic coefficients using a boundary element method code to solve the linear potential flow problem, and WEC-Sim, a MATLAB-based tool that simulates multibody devices in the time domain by solving the governing equations of motion. A 1:14 scale model of the device was built for experimental evaluation in an 8-m-long, 1-m wide wave tank, which supports a water depth of 0.7 m. The OSWEC motion in different wave conditions was measured with displacement sensors while nonlinear wave-structure interaction effects like slamming and overtopping were captured using a high-speed camera and used to understand differences between the simulation and experiments.

  8. Reference Model 5 (RM5): Oscillating Surge Wave Energy Converter

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Y. H. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jenne, D. S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thresher, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Copping, A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Geerlofs, S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hanna, L. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-01-01

    This report is an addendum to SAND2013-9040: Methodology for Design and Economic Analysis of Marine Energy Conversion (MEC) Technologies. This report describes an Oscillating Water Column Wave Energy Converter (OSWEC) reference model design in a complementary manner to Reference Models 1-4 contained in the above report. A conceptual design for a taut moored oscillating surge wave energy converter was developed. The design had an annual electrical power of 108 kilowatts (kW), rated power of 360 kW, and intended deployment at water depths between 50 m and 100 m. The study includes structural analysis, power output estimation, a hydraulic power conversion chain system, and mooring designs. The results were used to estimate device capital cost and annual operation and maintenance costs. The device performance and costs were used for the economic analysis, following the methodology presented in SAND2013-9040 that included costs for designing, manufacturing, deploying, and operating commercial-scale MEC arrays up to 100 devices. The levelized cost of energy estimated for the Reference Model 5 OSWEC, presented in this report, was for a single device and arrays of 10, 50, and 100 units, and it enabled the economic analysis to account for cost reductions associated with economies of scale. The baseline commercial levelized cost of energy estimate for the Reference Model 5 device in an array comprised of 10 units is $1.44/kilowatt-hour (kWh), and the value drops to approximately $0.69/kWh for an array of 100 units.

  9. A Case of Hypertensive Crisis without a Surge in Adrenal Hormones after Radiofrequency Ablation as a Treatment for Primary Hepatocellular Carcinoma.

    Science.gov (United States)

    Lee, Kyung Jin; Ryu, Soo Hyung

    2017-10-25

    Radiofrequency ablation (RFA) is a minimally invasive procedure that has been considered as a relatively safe treatment for patients with small hepatocellular carcinoma (HCC). However, RFA has been shown to be associated with complications including mechanical and thermal damage. A 74-year-old man with hepatitis C virus-associated HCC was admitted to our hospital. Abdominal computed tomography revealed two lobulated-HCC in segments 4 and 5. He had no medical history of hypertension and cardiac disease. During RFA, blood pressure was elevated to 200/140 mmHg. There was no evidence of pulmonary embolism, aortic dissection, or ischemic heart disease. Laboratory findings for catecholamine surge were all within normal limits. After continuous intravenous nitroglycerin and oral beta-blocker treatment, patient's blood pressure gradually decreased and back within the normal range. Hypertensive crisis after RFA treatment for HCC is rare. Most reported cases of hypertensive crisis during RFA were related to adrenal gland injury with a release of catecholamine. In our case, the site of HCC was not close to the adrenal gland, and there was no evidence of catecholamine surge. Herein, we report a very rare case of hypertensive crisis without a surge in adrenal hormones after RFA treatment for HCC.

  10. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... PD Expert Briefings: Parkinson's and Parenting Expert Briefings: Occupational Therapy and Parkinson's: Tips for Healthy Living Expert ... Nonmotor Symptoms of Parkinson's Disease Expert Briefings: Gait, Balance and Falls in Parkinson's Disease Expert Briefings: Coping ...

  11. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... for Parkinson's Care Partners OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Is the Progression ... Disease? What Are Some Strategies to Improve the Quality of Community Care for PD Patients? Hallucinations and ...

  12. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... How Does Parkinson's Disease Affect the Urinary System? 2013 PSA Featuring Katie Couric What Are Some Strategies ... Disease Affect Memory? OHSU - Therapeutic Approaches for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 ...

  13. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... of Parkinson's Disease Expert Briefings: Gait, Balance and Falls in Parkinson's Disease Expert Briefings: Coping Skills for ... or Exercise Programs Are Recommended? CareMAP: Movement and Falls: Part 1 Expert Briefings: Depression and PD: Treatment ...

  14. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Briefings: Dealing with Dementia in PD Expert Briefings: Anxiety in Parkinson's Disease Expert Briefings: Cognitive Issues: Advice ... and Tomorrow Expert Briefings: A Closer Look at Anxiety and Depression in Parkinson's Disease Expert Briefings: Driving ...

  15. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nursing Solutions: Innovations ... Parkinson's Disease: One Voice, Many Listeners Expert Briefings: Medical Therapies: What's in the Parkinson's Pipeline? Expert Briefings: ...

  16. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Briefings: Dealing with Dementia in PD Expert Briefings: Anxiety in Parkinson's Disease Expert Briefings: Nutrition and Parkinson's ... and Tomorrow Expert Briefings: A Closer Look at Anxiety and Depression in Parkinson's Disease Expert Briefings: Driving ...

  17. Glucose 6 phosphatase dehydrogenase (G6PD and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities

    Directory of Open Access Journals (Sweden)

    Manju Tiwari

    2017-12-01

    Full Text Available Glucose 6 phosphate dehydrogenase (G6PD is a key and rate limiting enzyme in the pentose phosphate pathway (PPP. The physiological significance of enzyme is providing reduced energy to specific cells like erythrocyte by maintaining co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH. There are preponderance research findings that demonstrate the enzyme (G6PD role in the energy balance, and it is associated with blood-related diseases and disorders, primarily the anemia resulted from G6PD deficiency. The X-linked genetic deficiency of G6PD and associated non-immune hemolytic anemia have been studied widely across the globe. Recent advancement in biology, more precisely neuroscience has revealed that G6PD is centrally involved in many neurological and neurodegenerative disorders. The neuroprotective role of the enzyme (G6PD has also been established, as well as the potential of G6PD in oxidative damage and the Reactive Oxygen Species (ROS produced in cerebral ischemia. Though G6PD deficiency remains a global health issue, however, a paradigm shift in research focusing the potential of the enzyme in neurological and neurodegenerative disorders will surely open a new avenue in diagnostics and enzyme therapeutics. Here, in this study, more emphasis was made on exploring the role of G6PD in neurological and inflammatory disorders as well as non-immune hemolytic anemia, thus providing diagnostic and therapeutic opportunities.

  18. A Cushing's syndrome patient's severe insomnia and morning blood pressure surge both improved after her left adrenal tumor resection.

    Science.gov (United States)

    Imaizumi, Yuki; Ibaraki, Ai; Asada, Satoshi; Tominaga, Mitsuhiro; Hayashi, Hiroyuki; Tsuchihashi, Takuya; Eguchi, Kazuo; Kario, Kazuomi; Taketomi, Akira

    2016-12-01

    Underlying mechanisms of the elevated risks of hypertension and cardiovascular disease (CVD) in Cushing's syndrome (CS) are unclear. We treated an adult woman with CS because of a cortisol-secreting adrenal tumor. After tumor resection, the 24-h blood pressure (BP) level improved from 156/91 to 131/84 mmHg; the morning BP surprisingly improved from 174/98 to 127/93 mmHg, although we reduced her antihypertensive medication. Her sleep quality (by the Pittsburgh Sleep Quality Index) improved from 7 to 2 points. Disturbed circadian BP rhythm is often observed in CS, but was reported only as altered nocturnal BP fall. This is the first report showing the disappearance of the morning BP surge evaluated by ambulatory BP monitoring with postsurgery sleep quality improvement. Poor-quality sleep, followed by exaggerated morning BP surge may thus be a cause of CS-related cardiovascular events. Sleep quality and BP circadian rhythm evaluations may clarify hypertension and high CVD risk in CS.

  19. Recent application of PET in the pathological mechanisms of PD

    International Nuclear Information System (INIS)

    Tian Jiyu

    2003-01-01

    PET is the best method in the investigation of molecular pathology at present. In this review, the value of positron emission computed tomography for providing insight into the role of pathology mechanism, early diagnosis, differential diagnosis, mechanisms of motor fluctuations in Parkinson disease is reviewed. Especially it can be used for the early diagnosis of PD, thus being beneficial to the therapy of it

  20. Alpha-synuclein in PD: pathogenesis and treatment

    Science.gov (United States)

    2010-11-01

    inclusions in nigral neurons in Parkinson disease (PD). Lysosome Associated Membrane Protein 1(LAMP1), Cathepsin D 5 ( CatD ), and Heat Shock Protein73 (HSP73...difference in LAMP1, CatD , HSP73 or 20S proteasome immunoreactivity between alpha-syn positive or negative neuromelanin-laden nigral neurons. Targeting

  1. KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS.

    Science.gov (United States)

    Fergani, C; Routly, J E; Jones, D N; Pickavance, L C; Smith, R F; Dobson, H

    2017-09-01

    In the ewe, steroid hormones act on the hypothalamic arcuate nucleus (ARC) to initiate the GnRH/LH surge. Within the ARC, steroid signal transduction may be mediated by estrogen receptive dopamine-, β-endorphin- or neuropeptide Y (NPY)-expressing cells, as well as those co-localising kisspeptin, neurokinin B (NKB) and dynorphin (termed KNDy). We investigated the time during the follicular phase when these cells become activated (i.e., co-localise c-Fos) relative to the timing of the LH surge onset and may therefore be involved in the surge generating mechanism. Furthermore, we aimed to elucidate whether these activation patterns are altered after lipopolysaccharide (LPS) administration, which is known to inhibit the LH surge. Follicular phases of ewes were synchronised by progesterone withdrawal and blood samples were collected every 2 h. Hypothalamic tissue was retrieved at various times during the follicular phase with or without the administration of LPS (100 ng/kg). The percentage of activated dopamine cells decreased before the onset of sexual behaviour, whereas activation of β-endorphin decreased and NPY activation tended to increase during the LH surge. These patterns were not disturbed by LPS administration. Maximal co-expression of c-Fos in dynorphin immunoreactive neurons was observed earlier during the follicular phase, compared to kisspeptin and NKB, which were maximally activated during the surge. This indicates a distinct role for ARC dynorphin in the LH surge generation mechanism. Acute LPS decreased the percentage of activated dynorphin and kisspeptin immunoreactive cells. Thus, in the ovary-intact ewe, KNDy neurones are activated prior to the LH surge onset and this pattern is inhibited by the administration of LPS. © 2017 Society for Reproduction and Fertility.

  2. Radiological analyses of France Telecom surge arresters. Study performed for the CGT FAPT Cantal

    International Nuclear Information System (INIS)

    2010-02-01

    This document reports the radiological characterization of various versions of surge arresters used in the past to protect telephone lines against over-voltages. These equipment, which use various radioactive materials, were assessed by gamma radiation flow measurements, alpha-beta-gamma count rate measurements, dose rate measurements, gamma spectrometry analyses, tritium emanation test, radon 222 emanation test, smearing. Recommendations are formulated to manage radioactive surge arresters which are still being operated

  3. Brazilian production development of class 2 polymeric surge arresters for transmission line application

    Energy Technology Data Exchange (ETDEWEB)

    Dellallibera, Adriano A. [Industria Eletromecanica Balestro, Mogi Mirim, SP (Brazil)], E-mail: adrianoad@balestro.com; Andrade, Antonio Donizetti de; Bezerra, Ana Cristina Guara; Duarte, Jose Vicente Pereira; Gois, Paulo Marcio Batista; Markiewicz, Rubens Leopoldo [Companhia Energetica de Minas Gerais (CEMIG), Belo Horizonte, MG (Brazil)], Emails: andonize@cemig.com.br, anacris@cemig.com.br, vicente@cemig.com.br, pgois@cemig.com.br, rlmark@cemig.com.br

    2007-07-01

    This paper shows the steeps of Brazilian class 2 ZnO lightning surge arrester development and production, aiming to attend the goal of CEMIG transmission lines performance improvement against lightning discharges action. The description of CEMIG transmission lines performance, before and after the ZnO lightning arresters installation, the necessity of use of ZnO lightning surge arrester, the prototypes manufacture, tests, problems and solutions are presented. (author)

  4. Data Assimilation within the Advanced Circulation (ADCIRC) Modeling Framework for Hurricane Storm Surge Forecasting

    KAUST Repository

    Butler, T.

    2012-07-01

    Accurate, real-time forecasting of coastal inundation due to hurricanes and tropical storms is a challenging computational problem requiring high-fidelity forward models of currents and water levels driven by hurricane-force winds. Despite best efforts in computational modeling there will always be uncertainty in storm surge forecasts. In recent years, there has been significant instrumentation located along the coastal United States for the purpose of collecting data—specifically wind, water levels, and wave heights—during these extreme events. This type of data, if available in real time, could be used in a data assimilation framework to improve hurricane storm surge forecasts. In this paper a data assimilation methodology for storm surge forecasting based on the use of ensemble Kalman filters and the advanced circulation (ADCIRC) storm surge model is described. The singular evolutive interpolated Kalman (SEIK) filter has been shown to be effective at producing accurate results for ocean models using small ensemble sizes initialized by an empirical orthogonal function analysis. The SEIK filter is applied to the ADCIRC model to improve storm surge forecasting, particularly in capturing maximum water levels (high water marks) and the timing of the surge. Two test cases of data obtained from hindcast studies of Hurricanes Ike and Katrina are presented. It is shown that a modified SEIK filter with an inflation factor improves the accuracy of coarse-resolution forecasts of storm surge resulting from hurricanes. Furthermore, the SEIK filter requires only modest computational resources to obtain more accurate forecasts of storm surge in a constrained time window where forecasters must interact with emergency responders.

  5. Validation of Delft3D as a Coastal Surge and Inundation Prediction System

    Science.gov (United States)

    2016-04-07

    Islands (USVI) and Punta Santiago, Puerto Rico (PR) before strengthening and approaching the Bahamas. Irene impacted Acklins/Crooked Island of the...H. Liu and M. Peng, 2008. The effect of wave-current interactions on the storm surge and inundation in Charleston Harbor during Hurricane Hugo 1989...A Navy relocatable tide/surge modeling system POM Princeton Ocean Model PR Puerto Rico RMS Root Mean Square RMSE Root Mean Square Error SRTM

  6. The Effect of Coastal Development on Storm Surge Flooding in Biscayne Bay, Florida, USA (Invited)

    Science.gov (United States)

    Zhang, K.; Liu, H.; Li, Y.

    2013-12-01

    Barrier islands and associated bays along the Atlantic and Gulf Coasts are a favorite place for both living and visiting. Many of them are vulnerable to storm surge flooding because of low elevations and constantly being subjected to the impacts of storms. The population increase and urban development along the barrier coast have altered the shoreline configuration, resulting in a dramatic change in the coastal flooding pattern in some areas. Here we present such a case based on numerical simulations of storm surge flooding caused by the1926 hurricane in the densely populated area surrounding Biscayne Bay in Miami, Florida. The construction of harbor and navigation channels, and the development of real estate and the roads connecting islands along Biscayne Bay have changed the geometry of Biscayne Bay since 1910s. Storm surge simulations show that the Port of Miami and Dodge Island constructed by human after 1950 play an important role in changing storm surge inundation pattern along Biscayne Bay. Dodge Island enhances storm surge and increases inundation in the area south of the island, especially at the mouth of Miami River (Downtown of Miami), and reduces storm surge flooding in the area north of the island, especially in Miami Beach. If the Hurricane Miami of 1926 happened today, the flooding area would be reduced by 55% and 20% in the Miami Beach and North Miami areas, respectively. Consequently, it would prevent 400 million of property and 10 thousand people from surge flooding according to 2010 U.S census and 2007 property tax data. Meanwhile, storm water would penetrate further inland south of Dodge Island and increase the flooding area by 25% in the Miami River and Downtown Miami areas. As a result, 200 million of property and five thousand people would be impacted by storm surge.

  7. G6PD: The Test

    Science.gov (United States)

    ... and Iron-binding Capacity (TIBC, UIBC) Trichomonas Testing Triglycerides Troponin Tryptase Tumor Markers Uric Acid Urinalysis Urine ... them from certain toxic by-products of cellular metabolism. A deficiency in G6PD causes RBCs to become ...

  8. Effect of Hydraulic Accumulator on Pressure Surge of a Hydrostatic Transmission System

    Science.gov (United States)

    Kumar, Ajit; Das, Jayanta; Dasgupta, Kabir; Barnwal, Manish Kumar

    2018-04-01

    Hydraulic power system is generally used in off-road vehicles for power transmission such as Heavy Earth Moving Machineries (HEMM). Their energy efficiency and unsubstantial failure becomes an extensive subject of analysis. Various arrangements in the system are compassed along with the utilization of some appropriate components. Application of a hydraulic accumulator is one among them. Benefits of accumulator is its multi-purpose usages like energy saving and pressure surge damping. This paper deals with the control of pressure surges in the hydraulic system and energy saving from the surges by using accumulator. For this purpose, the simulation of the hydraulic system is done in MATLAB/SimulinkR environment and an external disturbance is introduced to generate the pressure surge. The surge absorptivity of the accumulator is studied for different sizes at different pre-charged conditions of the accumulator. The discharge characteristics of different sized accumulators are also analyzed in this paper. It is observed that the ability to absorb the surge and stabilize the system is high in the smaller capacity accumulator. However the energy delivery time of larger sized accumulator is high.

  9. Modeling Flood Inundation Induced by River Flow and Storm Surges over a River Basin

    Directory of Open Access Journals (Sweden)

    Wei-Bo Chen

    2014-10-01

    Full Text Available Low-lying coastal regions and their populations are at risk during storm surge events and high freshwater discharges from upriver. An integrated storm surge and flood inundation modeling system was used to simulate storm surge and inundation in the Tsengwen River basin and the adjacent coastal area in southern Taiwan. A three-dimensional hydrodynamic model with an unstructured grid was used, which was driven by the tidal elevation at the open boundaries and freshwater discharge at the upriver boundary. The model was validated against the observed water levels for three typhoon events. The simulation results for the model were in reasonable agreement with the observational data. The model was then applied to investigate the effects of a storm surge, freshwater discharge, and a storm surge combined with freshwater discharge during an extreme typhoon event. The super Typhoon Haiyan (2013 was artificially shifted to hit Taiwan: the modeling results showed that the inundation area and depth would cause severe overbank flow and coastal flooding for a 200 year return period flow. A high-resolution grid model is essential for the accurate simulation of storm surges and inundation.

  10. Fluid-structure interaction analysis for pressurizer surge line subjected to thermal stratification

    International Nuclear Information System (INIS)

    Kang, Dong Gu; Jhung, Myung Jo; Chang, Soon Heung

    2011-01-01

    Research highlights: → Temperature of surge line due to stratified flow is defined using CFD analysis. → Fluid-structure interaction analysis is performed to investigate the response characteristics due to thermal stress. → Fatigue usage factors due to thermal stratification are relatively low. → Simplifying temperature distribution in surge line is not always conservative. - Abstract: Serious mechanical damages such as cracks and plastic deformations due to excessive thermal stress caused by thermal stratification have been experienced in several nuclear power plants. In particular, the thermal stratification in the pressurizer surge line has been addressed as one of the significant safety and technical issues. In this study, a detailed unsteady computational fluid dynamics (CFD) analysis involving conjugate heat transfer analysis is performed to obtain the transient temperature distributions in the wall of the pressurizer surge line subjected to stratified internal flows either during out-surge or in-surge operation. The thermal loads from CFD calculations are transferred to the structural analysis code which is employed for the thermal stress analysis to investigate the response characteristics, and the fatigue analysis is ultimately performed. In addition, the thermal stress and fatigue analysis results obtained by applying the realistic temperature distributions from CFD calculations are compared with those by assuming the simplified temperature distributions to identify some requirements for a realistic and conservative thermal stress analysis from a safety point of view.

  11. Storm surge evolution and its relationship to climate oscillations at Duck, NC

    Science.gov (United States)

    Munroe, Robert; Curtis, Scott

    2017-07-01

    Coastal communities experience increased vulnerability during storm surge events through the risk of damage to coastal infrastructure, erosion/deposition, and the endangerment of human life. Policy and planning measures attempt to avoid or mitigate storm surge consequences through building codes and setbacks, beach stabilization, insurance rates, and coastal zoning. The coastal emergency management community and public react and respond on shorter time scales, through temporary protection, emergency stockpiling, and evacuation. This study utilizes time series analysis, the Kolmogorov-Smirnov (K-S) test, Pearson's correlation, and the generalized extreme value (GEV) theorem to make the connection between climate oscillation indices and storm surge characteristics intra-seasonally to inter-annually. Results indicate that an El Niño (+ENSO), negative phase of the NAO, and positive phase of the PNA pattern all support longer duration and hence more powerful surge events, especially in winter. Increased surge duration increases the likelihood of extensive erosion, inland inundation, among other undesirable effects of the surge hazard.

  12. Cortisol Interferes with the Estradiol-Induced Surge of Luteinizing Hormone in the Ewe1

    Science.gov (United States)

    Wagenmaker, Elizabeth R.; Breen, Kellie M.; Oakley, Amy E.; Pierce, Bree N.; Tilbrook, Alan J.; Turner, Anne I.; Karsch, Fred J.

    2008-01-01

    Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge. Ovariectomized sheep were treated sequentially with progesterone and estradiol to create artificial estrous cycles. Cortisol or vehicle (saline) was infused from 2 h before the estradiol stimulus through the time of the anticipated LH surge in the artificial follicular phase of two successive cycles. The plasma cortisol increment produced by infusion was ∼1.5 times greater than maximal concentrations seen during infusion of endotoxin, which is a model of immune/inflammatory stress. In experiment 1, half of the ewes received vehicle in the first cycle and cortisol in the second; the others were treated in reverse order. All ewes responded with an LH surge. Cortisol delayed the LH surge and reduced its amplitude, but both effects were observed only in the second cycle. Experiment 2 was modified to provide better control for a cycle effect. Four treatment sequences were tested (cycle 1-cycle 2): vehicle-vehicle, cortisol-cortisol, vehicle-cortisol, cortisol-vehicle. Again, cortisol delayed but did not block the LH surge, and this delay occurred in both cycles. Thus, an elevation in plasma cortisol can interfere with the positive feedback action of estradiol by delaying and attenuating the LH surge. PMID:19056703

  13. Cholinergic control of the nocturnal prolactin surge in the pseudopregnant rat.

    Science.gov (United States)

    McLean, B K; Nikitovitch-Winer, M B

    1975-10-01

    The possible involvement of cholinergic mechanisms in the control of rhythmic secretion of prolactin has been examined in the pseudopregnant rat. Baseline data were obtained in decapitated animals in which the diuranl surge was observed in the 1430--2030 h range and the nocturnal surge during the 2330-0530 h interval. Atrial cannulation permitted a faithful reproduction of the prolactin pattern seen in decapitated rats if at least 3 days elapsed between the cannulation operation and bleeding, while cardiac puncture, under light ether anesthesia, appeared to suppress the diurnal surge. This latter observation appeared to depend on the time of sampling in relation to the onset of the dark phase of the daily lighting cycle. Atropine (35 or 70 mg/100 g BW) was found to inhibit the nocturnal surge in animals bled by either the cardiac puncture or cannulation techniques --an effect which was reversed by pretreatment with eserine (50 or 100 mug/100 g BW). Nicotine (0.75 mg/100 g BW) was found to delay, but not completely to inhibit, the nocturnal surge. When evaluated in the light of other available information, these observations suggest that a complex cholinergic mechanism is involved in control of the nocturnal rhythm of prolactin in pseudopregnancy and that the two surges, diurnal and nocturnal, are differentially controlled.

  14. Modeling and simulation of storm surge on Staten Island to understand inundation mitigation strategies

    Science.gov (United States)

    Kress, Michael E.; Benimoff, Alan I.; Fritz, William J.; Thatcher, Cindy A.; Blanton, Brian O.; Dzedzits, Eugene

    2016-01-01

    Hurricane Sandy made landfall on October 29, 2012, near Brigantine, New Jersey, and had a transformative impact on Staten Island and the New York Metropolitan area. Of the 43 New York City fatalities, 23 occurred on Staten Island. The borough, with a population of approximately 500,000, experienced some of the most devastating impacts of the storm. Since Hurricane Sandy, protective dunes have been constructed on the southeast shore of Staten Island. ADCIRC+SWAN model simulations run on The City University of New York's Cray XE6M, housed at the College of Staten Island, using updated topographic data show that the coast of Staten Island is still susceptible to tidal surge similar to those generated by Hurricane Sandy. Sandy hindcast simulations of storm surges focusing on Staten Island are in good agreement with observed storm tide measurements. Model results calculated from fine-scaled and coarse-scaled computational grids demonstrate that finer grids better resolve small differences in the topography of critical hydraulic control structures, which affect storm surge inundation levels. The storm surge simulations, based on post-storm topography obtained from high-resolution lidar, provide much-needed information to understand Staten Island's changing vulnerability to storm surge inundation. The results of fine-scale storm surge simulations can be used to inform efforts to improve resiliency to future storms. For example, protective barriers contain planned gaps in the dunes to provide for beach access that may inadvertently increase the vulnerability of the area.

  15. ISSN 2073-9990 East Cent. Afr. J. surg. (Online)

    African Journals Online (AJOL)

    dell

    Background: Hirschsprung disease is congenital disease caused by a lack of ganglion cells in the distal bowel wall which results in functional obstruction of the aganglionic segment due to failure of relaxation during peristalsis. Barium enema is the best imaging modality to diagnose Hirschsprung disease but the gold ...

  16. Dysphagia in Parkinson's Disease.

    Science.gov (United States)

    Suttrup, Inga; Warnecke, Tobias

    2016-02-01

    More than 80 % of patients with Parkinson's disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD patients is challenging and often delivers unreliable results. A modified water test assessing maximum swallowing volume is recommended to uncover oropharyngeal dysphagia in PD. PD-specific questionnaires may also be useful to identify patients at risk for swallowing impairment. Fiberoptic endoscopic evaluation of swallowing and videofluoroscopic swallowing study are both considered to be the gold standard for evaluation of PD-related dysphagia. In addition, high-resolution manometry may be a helpful tool. These instrumental methods allow a reliable detection of aspiration events. Furthermore, typical patterns of impairment during the oral, pharyngeal and/or esophageal swallowing phase of PD patients can be identified. Therapy of dysphagia in PD consists of pharmacological interventions and swallowing treatment by speech and language therapists (SLTs). Fluctuating dysphagia with deterioration during the off-state should be treated by optimizing dopaminergic medication. The methods used during swallowing treatment by SLTs shall be selected according to the individual dysphagia pattern of each PD patient. A promising novel method is an intensive training of expiratory muscle strength. Deep brain stimulation does not seem to have a clinical relevant effect on swallowing function in PD. The goal of this review is giving an overview on current stages of epidemiology, pathophysiology, diagnosis, and treatment of PD-associated dysphagia, which might be helpful for neurologists

  17. Identification of storm surge vulnerable areas in the Philippines through the simulation of Typhoon Haiyan-induced storm surge levels over historical storm tracks

    Directory of Open Access Journals (Sweden)

    J. P. Lapidez

    2015-07-01

    Full Text Available Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR on 7 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the storm surge and strong winds. Storm surges up to a height of 7 m were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards (Project NOAH which is the flagship disaster mitigation program of the Department of Science and Technology (DOST of the Philippine government to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948–2013. One product of this study is a list of the 30 most vulnerable coastal areas that can be used as a basis for choosing priority sites for further studies to implement appropriate site-specific solutions for flood risk management. Another product is the storm tide inundation maps that the local government units can use to develop a risk-sensitive land use plan for identifying appropriate areas to build residential buildings, evacuation sites, and other critical facilities and lifelines. The maps can also be used to develop a disaster response plan and evacuation scheme.

  18. Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

    Directory of Open Access Journals (Sweden)

    M. Onofrj

    2013-01-01

    Full Text Available Visual Hallucinations (VH are a common non-motor symptom of Parkinson’s Disease (PD and the Lewy body dementias (LBD of Parkinson's disease with dementia (PDD and Dementia with Lewy Bodies (DLB. The origin of VH in PD and LBD is debated: earlier studies considered a number of different possible mechanisms underlying VH including visual disorders, Rapid Eye Movement (REM Sleep Intrusions, dysfunctions of top down or bottom up visual pathways, and neurotransmitter imbalance.

  19. Development of Low Surge Vacuum Contact with Te

    Energy Technology Data Exchange (ETDEWEB)

    Kim, B. S.; Lee, H. W.; Woo, B. C.; Kim, B. G. [Korea Electrotechnology Research Institute, Changwon (Korea, Republic of)

    1996-12-01

    The purpose of this study is to develop of low surge Te contact for vacuum circuit breaker. The vacuum circuit breaker have various advantages such that it is free from maintenance, does not bring about public pollution, is excellent in its current breaking property, and so forth, on account of which the extent of its application has become broadened rapidly. For the characteristics of the contact material for the vacuum circuit breaker to satisfy, there may be enumerated: (1)large current breaking capacity; (2)high voltage withstand; (3)small contact resistance; (4)small melt-adhesive force; (5)low chopping current value; (6)good workability; (7)sufficient mechanical strength; and so forth. In this study we used cobalt for based refractory material having high melting temperature and intermetallic material between tellurium and silver to reduce chopping current. The contact materials were produced in accordance with the powder metallurgy using the method of infiltration. Production of the contact material was carried out in such a method that cobalt powder having average particle size of 50{mu}m, pre sintered in H{sub 2} atmosphere, 900 degree C , 2 hour. Ag ingot and Te(Se) were alloyed using high frequency furnaced in vacuum. And then Ag-Te(Se) alloy was infiltrated to Co skeleton in H{sub 2} atmosphere, 1000 degree C , 1 hour. The melting of the alloy to be infiltrated was carried out in a vacuum sealed quartz tube and be analysed by X-ray diffraction, scanning electron microscope, optical microscope and energy dispersive energy spectrometer. In the alloying of silver and tellurium, tellurium does not exist in single element but Ag{sub 2}Te intermetallic compound. And In Ag and Se, Se does not exist in single element but Ag{sub 2}Se intermetallic compound. We also produced the test vacuum interruptor to evaluate the electrode properties in vacuum atmosphere. The electrical properties of Co-(Ag-Se) electrode have better value than that of Co-(Ag-Te) electrode

  20. Coffee, Genetic Variants, and Parkinson's Disease: Gene–Environment Interactions

    OpenAIRE

    Yamada-Fowler, Naomi; Söderkvist, Peter

    2015-01-01

    Studies of gene–environment interactions may help us to understand the disease mechanisms of common and complex diseases such as Parkinson's disease (PD). Sporadic PD, the common form of PD, is thought to be a multifactorial disorder caused by combinations of multiple genetic factors and environmental or life-style exposures. Since one of the most extensively studied life-style factors in PD is coffee/caffeine intake, here, the studies of genetic polymorphisms with life-style interactions of ...

  1. Evidence for a luteinizing hormone surge center in the hypothalamus of the pig.

    Science.gov (United States)

    Kraeling, R R; Johnson, B; Barb, C R; Rampacek, G B

    1998-05-01

    Studies were conducted to determine whether there is an LH surge generator in the hypothalamus of the pig. In experiment 1, 157-day-old ovariectomized (OVX) gilts received 1.5 microg estradiol benzoate (EB)/kg BW i.m. every 12 h from 0 through 24, 48, 72, or 96 h. Blood was sampled every 6 h from 3 to 36 h and every 3 h from 36 through 144 h. One of 3, 4 of 4, 4 of 4, and 2 of 3 gilts displayed an LH surge after treatment for 24, 48, 72, and 96 h, respectively. With the exception that time to maximum LH concentration was greater in gilts treated for 96 h than in those treated for 72 h (p gilts. In experiment 2a, an Alzet osmotic pump containing EB or vehicle was inserted s.c. behind an ear of 124-day-old OVX gilts, resulting in the following daily doses of EB: 0, 0.75, 1.50, or 3.00 microg/kg BW. Blood was sampled at 0, 2, 4, 6, and 8 h and every 8 h thereafter through 168 h to evaluate surge secretion of LH, and every 15 min for 8 h starting at 168 h to evaluate pulsatile LH secretion. Zero of 3, 0 of 2, 3 of 3, and 3 of 3 gilts displayed an LH surge after 0, 0.75, 1.50, and 3.00 microg EB/kg BW, respectively. Parameters of the surge were similar among gilts. Pulsatile LH secretion, evaluated 7 days after pump insertion, was significantly suppressed for estradiol-treated gilts compared to controls. In experiment 2b, at 182 days of age, 10 gilts used in experiment 2a plus 2 additional gilts in the original group prepared but not used for experiment 2a, were randomly assigned in groups (n=3) to the following daily doses of EB: 0, 0.19, 0.38, or 0.75 microg/kg BW, administered again by osmotic pump. Treatment and blood-sampling schedules were the same as in experiment 2a. Zero, 0, 1, and 2 gilts displayed an LH surge after treatment with 0, 0.19, 0.38, and 0.75 microg EB/kg BW, respectively. Parameters of the surge were similar among gilts that displayed an LH surge. Pulsatile LH secretion was significantly suppressed for estradiol-treated gilts compared to controls

  2. Comparing PD results with visual inspection

    International Nuclear Information System (INIS)

    Rossi, A.; Stone, G.C.

    2005-01-01

    ENEL is the main generation utility in Italy, with more than 200 hydro units and 120 turbine generators, totaling 39,000 MW of capacity. To help identify the maintenance needs of the stator windings in these units, ENEL has been gradually equipping the generators with partial discharge (PD) sensors that facilitate an on-line measurement of the PD. The paper describes results from several machines that have PD. In all cases, the high PD was confirmed by visual inspections. Although PD usually found the units with severe insulation problems, it was not always possible to determine the causes of the deterioration from the PD pattern. (author)

  3. Glucose-6-phosphate dehydrogenase (G6PD) deficiency in nonarteritic anterior ischemic optic neuropathy in a Sardinian population, Italy.

    Science.gov (United States)

    Pinna, Antonio; Solinas, Giuliana; Masia, Carlo; Zinellu, Angelo; Carru, Ciriaco; Carta, Arturo

    2008-04-01

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against ischemic heart and cerebrovascular disease and retinal vein occlusion. The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with nonarteritic anterior ischemic optic neuropathy (NAION) and ascertain whether G6PD deficiency may offer protection against NAION. Erythrocyte G6PD activity was determined by using a quantitative assay in 140 patients with NAION and 280 age- and gender-matched comparison patients. Conditional logistic regression models were used to investigate the association between G6PD deficiency and NAION. G6PD deficiency was found in 7 (5%) patients with NAION and 34 (12.1%) control subjects. Differences between cases and controls were statistically significant (P = 0.02). Conditional logistic regression analysis, including as covariates G6PD deficiency, hypertension, diabetes, and hypercholesterolemia, revealed that G6PD deficiency was significantly associated with decreased risk for NAION (odds ratio [OR] = 0.4, 95% confidence interval [CI] = 0.17-0.94, P = 0.035). Conditional logistic regression analyses, including systolic or diastolic blood pressure and plasma glucose and cholesterol levels confirmed that G6PD deficiency was associated with a decreased risk for NAION, but the ORs were not significant at the 0.05 significance level (P = 0.085 and P = 0.071). Models including gender x G6PD deficiency interaction disclosed that gender was not an effect modifier of G6PD deficiency (P > 0.20). The frequency of G6PD deficiency in patients with NAION was significantly lower than expected. Results suggest that G6PD-deficient patients in the Sardinian population have a significantly decreased risk of having NAION.

  4. Health systems' "surge capacity": state of the art and priorities for future research.

    Science.gov (United States)

    Watson, Samantha K; Rudge, James W; Coker, Richard

    2013-03-01

    Over the past decade, a number of high-impact natural hazard events, together with the increased recognition of pandemic risks, have intensified interest in health systems' ability to prepare for, and cope with, "surges" (sudden large-scale escalations) in treatment needs. In this article, we identify key concepts and components associated with this emerging research theme. We consider the requirements for a standardized conceptual framework for future research capable of informing policy to reduce the morbidity and mortality impacts of such incidents. Here our objective is to appraise the consistency and utility of existing conceptualizations of health systems' surge capacity and their components, with a view to standardizing concepts and measurements to enable future research to generate a cumulative knowledge base for policy and practice. A systematic review of the literature on concepts of health systems' surge capacity, with a narrative summary of key concepts relevant to public health. The academic literature on surge capacity demonstrates considerable variation in its conceptualization, terms, definitions, and applications. This, together with an absence of detailed and comparable data, has hampered efforts to develop standardized conceptual models, measurements, and metrics. Some degree of consensus is evident for the components of surge capacity, but more work is needed to integrate them. The overwhelming concentration in the United States complicates the generalizability of existing approaches and findings. The concept of surge capacity is a useful addition to the study of health systems' disaster and/or pandemic planning, mitigation, and response, and it has far-reaching policy implications. Even though research in this area has grown quickly, it has yet to fulfill its potential to generate knowledge to inform policy. Work is needed to generate robust conceptual and analytical frameworks, along with innovations in data collection and methodological

  5. Sleep disorders in Parkinson?s disease

    OpenAIRE

    Jahan, Israt; Hauser, Robert A; Sullivan, Kelly L; Miller, Amber; Zesiewicz, Theresa A

    2009-01-01

    Sleep disorders occur commonly in Parkinson?s disease (PD), and reduce quality of life. Sleep-related problems in PD include insomnia, restless legs syndrome, rapid eye movement sleep behavior disorder, sleep apnea, parasomnias, excessive daytime sleepiness, and sleep attacks. This article reviews sleep disorders and their treatment in PD.

  6. Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression.

    Science.gov (United States)

    Said, Sawsan Sudqi; Barut, Guliz Tuba; Mansur, Nesteren; Korkmaz, Asli; Sayi-Yazgan, Ayca

    2018-04-01

    Regulatory B cells (Bregs) play a crucial role in immunological tolerance primarily through the production of IL-10 in many diseases including autoimmune disorders, allergy, infectious diseases, and cancer. To date, various Breg subsets with overlapping phenotypes have been identified. However, the roles of Bregs in Helicobacter infection are largely unknown. In the present study, we investigate the phenotype and function of Helicobacter -stimulated B cells. Our results demonstrate that Helicobacter felis -stimulated IL-10- producing B cells (Hf stim - IL-10 + B) are composed of B10 and Transitional 2 Marginal Zone Precursor (T2-MZP) cells with expression of CD9, Tim-1, and programmed death 1 (PD-1). On the other hand, Helicobacter felis -stimulated IL-10- nonproducing B (Hf stim - IL-10 - B) cells are mainly marginal zone (MZ) B cells that express PD-L1 and secrete TGF-β, IL-6, and TNF-α, and IgM and IgG2b. Furthermore, we show that both Hf stim - IL-10 + B cells and Hf stim - IL-10 - B cells induce CD49b + LAG-3 + Tr1 cells. Here, we describe a novel mechanism for PD-1/PD-L1- driven B cell-dependent Tr1 cell differentiation. Finally, we explore the capability of Hf stim - IL-10 - B cells to induce Th17 cell differentiation, which we find to be dependent on TGF-β. Taken together, the current study demonstrates that Hf stim - B cells induce Tr1 cells through the PD-1/PD-L1 axis and Th17 cells by secreting TGF-β. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Valued eMachines Customer

    whom there is no history of hereditary/congenital diseases. ... muscles. The left biceps branchi muscle was hypoplastic. There were passive and active movements at the right elbow. There were neither movements nor angular deformity ... Both parents were not reactive to VDRL (venereal diseases research laboratory) test.

  8. Cardiometabolic factors and disease duration in patients with Parkinson's disease.

    Science.gov (United States)

    Cassani, Erica; Cereda, Emanuele; Barichella, Michela; Madio, Carmen; Cancello, Raffaella; Caccialanza, Riccardo; Zini, Michela; Cilia, Roberto; Pezzoli, Gianni

    2013-01-01

    Previous studies have reported that patients with Parkinson's disease (PD) have a favorable cardiometabolic risk profile. The aim of this study was to investigate the relationship between cardiometabolic risk factors and the duration of disease. One hundred and fifty patients with PD (56.7% men) were studied, measuring body mass index (BMI), waist circumference (WC), body fat percentage (BF%) by impedance, fasting glucose, serum lipids, and transaminases. In sex- and age-adjusted correlation models, duration of PD was inversely related to BMI (r = -0.20; P HDL) levels were positively correlated with disease duration (P HDL-cholesterol ratio was also inversely associated with duration of PD (P HDL levels and total HDL-cholesterol ratio were favorably associated with duration of PD. This factor may contribute to cardiometabolic protection in PD. The mechanisms underlying this association deserve further investigation. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... PD: What You Need to Know Expert Briefings: Cognition and PD: What You've Always Wanted to ... How Does Depression Affect the Patient's Family and Social Network? Parkinson’s Disease Psychosis: A Caregiver’s Story CareMAP: ...

  10. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Your Area Resources & Support PD Library Legal, Financial, & Insurance Matters Blog For Caregivers Living with Parkinson's While living with PD can be challenging, there are many things you can do to maintain and improve your quality of life and live well with Parkinson's disease. Learn More ...

  11. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... What Do I Do if I Suspect Compulsive Behavior in a Loved One with PD? What Medications Help with Cognitive Impairment? How Do PD and Its Treatment Affect Sexual Functioning? Parkinson’s Disease Psychosis: A Caregiver’s Story CareMAP: Balancing Life and ...

  12. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ... and Scheduling: Part 2 What Are the Common Sleep Disorders Encountered in Patients with PD? CareMAP: Planear y ...

  13. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Area Resources & Support PD Library Legal, Financial, & Insurance Matters Blog For Caregivers Living with Parkinson's While living with PD can be challenging, there are many things you can do to maintain and improve your quality of life and live well with Parkinson's disease. Learn More Expert Care ...

  14. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Soy el compas de otra canción” Expert Briefings: Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nursing Solutions: Innovations in ...

  15. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nursing ... Therapeutic Approaches for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 CareMAP: Bathroom: Part 1 ...

  16. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... A A You are here Home PD Library Search library Topic Type Expert Briefings: Marijuana and PD: What Do We Really Know? Nurse Webinars: Nursing Solutions: Improving Caregiver Strain through Science and Model Interventions Expert Briefings: Parkinson's Disease Psychosis: ...

  17. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's Disease Expert Briefings: Getting Around: Transportation and Travel with PD Expert Briefings: Sleep and Parkinson's Nurse: ... Therapeutic Approaches for PD: Depression, Anxiety & Psychosis CareMAP: Travel and Transportation: Part 2 CareMAP: Bathroom: Part 1 ¿ ...

  18. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... But Were Too Afraid to Ask Expert Briefings: Physical Therapy & PD: What You Need to Know Expert Briefings: What's Missing? Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the Parkinson's Pipeline? ...

  19. Parkinson's disease and anxiety

    OpenAIRE

    Walsh, K; Bennett, G

    2001-01-01

    There has been a recent surge of interest in the subject of anxiety in patients with Parkinson's disease. Up to 40% of patients with Parkinson's disease experience clinically significant anxiety. This anxiety may be a psychological reaction to the stress of the illness or may be related to the neurochemical changes of the disease itself. Antiparkinsonian drugs may have a role in the pathogenesis of the anxiety. The anxiety disorders in Parkinson's disease patients appear to be clustered in th...

  20. Alternative splice variants of the human PD-1 gene

    DEFF Research Database (Denmark)

    Nielsen, Christian; Ohm-Laursen, Line; Barington, Torben

    2005-01-01

    PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1...

  1. Improvement of Performance Range of Centrifugal Compressors Gas by Surge Line Modification Using Active Controller Based on Fuzzy Logic

    Directory of Open Access Journals (Sweden)

    Pezhman Mohammadi

    2012-04-01

    Full Text Available In this work, surge of prevention is a critical problem in oil and gas industries, particularly when return gas flow or gas flow reduces in transportation of gas pipelines. This paper is illustrated new results about surge control of centrifugal compressors .surge phenomenon is flow unsteady state in compressors which causes damages seriously in compressor construction. Furthermore, it also demonstrates in comparison with anti surge control ،active surge control expands stability range.Active surge control which based on fuzzy logic،is the main idea that used in this investigation. Using fuzzy controller causes an improvement in compressor's condition and increase performance range of the compressor, in addition to prevention of any instability in compressor. The simulation results is also satisfactory.

  2. InSAR Observations and Finite Element Modeling of Crustal Deformation Around a Surging Glacier, Iceland

    Science.gov (United States)

    Spaans, K.; Auriac, A.; Sigmundsson, F.; Hooper, A. J.; Bjornsson, H.; Pálsson, F.; Pinel, V.; Feigl, K. L.

    2014-12-01

    Icelandic ice caps, covering ~11% of the country, are known to be surging glaciers. Such process implies an important local crustal subsidence due to the large ice mass being transported to the ice edge during the surge in a few months only. In 1993-1995, a glacial surge occurred at four neighboring outlet glaciers in the southwestern part of Vatnajökull ice cap, the largest ice cap in Iceland. We estimated that ~16±1 km3 of ice have been moved during this event while the fronts of some of the outlet glaciers advanced by ~1 km.Surface deformation associated with this surge has been surveyed using Interferometric Synthetic Aperture Radar (InSAR) acquisitions from 1992-2002, providing high resolution ground observations of the study area. The data show about 75 mm subsidence at the ice edge of the outlet glaciers following the transport of the large volume of ice during the surge (Fig. 1). The long time span covered by the InSAR images enabled us to remove ~12 mm/yr of uplift occurring in this area due to glacial isostatic adjustment from the retreat of Vatnajökull ice cap since the end of the Little Ice Age in Iceland. We then used finite element modeling to investigate the elastic Earth response to the surge, as well as confirm that no significant viscoelastic deformation occurred as a consequence of the surge. A statistical approach based on Bayes' rule was used to compare the models to the observations and obtain an estimate of the Young's modulus (E) and Poisson's ratio (v) in Iceland. The best-fitting models are those using a one-kilometer thick top layer with v=0.17 and E between 12.9-15.3 GPa underlain by a layer with v=0.25 and E from 67.3 to 81.9 GPa. Results demonstrate that InSAR data and finite element models can be used successfully to reproduce crustal deformation induced by ice mass variations at Icelandic ice caps.Fig. 1: Interferograms spanning 1993 July 31 to 1995 June 19, showing the surge at Tungnaárjökull (Tu.), Skaftárjökull (Sk.) and S

  3. Assessment of the Temporal Evolution of Storm Surge via Land to Water Isopleths in Coastal Louisiana

    Science.gov (United States)

    Siverd, C. G.; Hagen, S. C.; Bilskie, M. V.; Braud, D.; Gao, S.; Peele, H.; Twilley, R.

    2017-12-01

    The low-lying coastal Louisiana deltaic landscape features an intricate system of fragmented wetlands, natural ridges, man-made navigation canals and flood protection infrastructure. Since 1900 and prior to the landfall of Hurricane Katrina in 2005, Louisiana lost approximately 480,000 ha (1,850 sq mi) of coastal wetlands and an additional 20,000 ha (77 sq mi) due to Katrina. This resulted in a total wetland storm protection value loss of USD 28.3 billion and USD 1.1 billion, respectively (Costanza 2008). To investigate the response of hurricane storm surge (e.g. peak water levels, inundation time and extent) through time due to land loss, hydrodynamic models that represent historical eras of the Louisiana coastal landscape were developed. Land:Water (L:W) isopleths (Gagliano 1970, 1971, Twilley 2016) have been calculated along the coast from the Sabine River to the Pearl River. These isopleths were utilized to create a simplified coastal landscape (bathymetry, topography, bottom roughness) representing circa 2010. Similar methodologies are employed with the objective of developing storm surge models that represent the coastal landscape for past eras. The goal is to temporally examine the evolution of storm surge along coastal Louisiana. The isopleths determined to best represent the Louisiana coast as a result of the methodology devised to develop the simple storm surge model for c.2010 are applied in the development of surge models for historical eras c.1930 and c.1970. The ADvaced CIRCulation (ADCIRC) code (Luettich 2004) is used to perform storm surge simulations with a predetermined suite of hurricane wind and pressure forcings. Hydrologic Unit Code 12 (HUC12) sub-watersheds provide geographical bounds to quantify mean maximum water surface elevations (WSEs), volume of inundation, and area of inundation. HUC12 sub-watersheds also provide a means to compare/contrast these quantified surge parameters on a HUC12-by-HUC12 basis for the c.1930, c.1970 and c.2010

  4. Hyposmia Is Associated with RBD for PD Patients with Variants of SNCA

    Directory of Open Access Journals (Sweden)

    Yuanyuan Li

    2017-09-01

    Full Text Available Objective: Hyposmia may occur simultaneously with REM sleep behavior disorder (RBD as a specific phenotype in Parkinson's Diseases (PD, of which the disease progression is fast. In the study, we tried to identify whether the genotypic characteristics could participate in the co-occurrence of hyposmia and RBD in PD patients.Methods: 152 PD patients were recruited from the Department of Neurology, Ruijin Hospital affiliated to Shanghai JiaoTong University School of Medicine from 2011 to 2016, with comprehensive clinical assessment performing. Two SNPs of SNCA (rs11931074 and rs894278 in 105 patients were also analyzed.Results: Overall, 84 of 152 PD patients (55.3% were diagnosed with RBD after PSG evaluation. After regression analysis, higher levels of three parts of UPDRS and SCOPA-AUT scores were all associated with increased risk of RBD in PD patients, respectively. While for olfactory function, we didn't find significant correlation between hyposmia and RBD in PD patients. However, we found that in the group of minor G allele of rs894278, patients with lower score of SS-16 had a 4.76-fold risk of suffering from RBD in patients (95% CI: 1.39–16.67; p = 0.013. Furthermore, we analyzed SNP associated gene expression by eQTL analysis in Genevar database and found that GG genotype of rs894278 was associated with higher levels of α-synuclein in Nerve tissue (p = 1.5E-8 while TT genotype of rs11931074 was associated with higher levels of α-synuclein in Brain (p = 0.0082, which suggesting a potential functional relevance with different symptoms of PD.Conclusions: Hyposmia was associated with RBD in PD patients with the minor G allele of rs894278, which represent one specific subtype of PD. This study could provide more detail information about PD subtype of RBD with hyposmia in the future.

  5. What Is the Best Dialysis Therapy for South Asia: HD or PD?

    Science.gov (United States)

    Pavan, K R N; Subhramanyam, S V; Karopadi, A N; Sinoj, K A; Nayak, K S

    2017-01-01

    South Asian countries have a population of 1.7 billion and are classified as low-middle to poor income nations. Their health care systems cannot presently meet the growing need for renal replacement therapy (RRT), provided as haemodialysis or peritoneal dialysis (PD). Most patients cannot afford the treatment and quickly default. Furthermore, most of the population is located in rural areas, where there are few treatment centres; therefore, there is a huge gap between those treated and those in need. PD can bridge this gap and can serve as a first line of therapy if it becomes more affordable. Government reimbursement schemes, the Once-in-a-Lifetime Payment Scheme, and PD insurance all provide strong impetus to dialysis programmes. Local manufacturing of PD fluid has also reduced the cost of therapy to some extent. PD may be preferable for patients with cardiovascular morbidity and it also obviates the risk of transmission of blood-borne diseases such as HIV, hepatitis B, and hepatitis C. In our own centre, automated PD is being used as initial RRT for acute kidney injury with good results. In prospective transplant recipients, PD has been found to decrease the risk of posttransplant graft dysfunction. Key Messages: Remote PD and home visits by PD clinical coordinators have brought faraway patients and their nephrologists closer with the use of technology. For these reasons, the current pressing need is to bring PD to the forefront of RRT in resource-poor countries in South Asia to enable universal treatment of patients with renal disease. © 2017 S. Karger AG, Basel.

  6. [Analysis of articles published in Chin J Surg since founded in 1951].

    Science.gov (United States)

    Xia, Shuang; Li, Jing

    2016-01-01

    To discuss the characteristics of the articles published in Chin J Surg from 1951 to 2015. The journals and articles of Acad Surg from 1951 to 1952 and Chin J Surg from 1953 to 2015 were analyzed. The subjects, foundation, basic medical study, international cooperation of the articles were recorded. In 65 years, there were 20 090 academic articles published in Chin J Surg. The proportions of general surgery, orthopedic surgery, thoracocardiac surgery, urology surgery and neurosurgery articles were 34.08%, 17.96%, 13.09%, 11.91% and 5.85%, respectively. There were 14.83% (1 728/11 653) articles receiving foundation, and 9.42% (1 817/19 290) articles reporting basic medical study. There were 14.8% articles from international authors and 119 articles with international cooperation. From 2000 to 2003, 29 articles in original English were published. The coverage of Chin J Surg contains all the fields of surgery. It tends to publish the studies focus on clinical issues.Through reinforcing the content plan and optimizing the show form, the more Chinese surgical research achievements could be shared by the surgeons worldwide.

  7. A new on-line leakage current monitoring system of ZnO surge arresters

    International Nuclear Information System (INIS)

    Lee, Bok-Hee; Kang, Sung-Man

    2005-01-01

    This paper presents a new on-line leakage current monitoring system of zinc oxide (ZnO) surge arresters. To effectively diagnose the deterioration of ZnO surge arresters, a new algorithm and on-line leakage current detection device, which uses the time-delay addition method, for discriminating the resistive and capacitive currents was developed to use in the aging test and durability evaluation for ZnO arrester blocks. A computer-based measurement system of the resistive leakage current, the on-line monitoring device can detect accurately the leakage currents flowing through ZnO surge arresters for power frequency ac applied voltages. The proposed on-line leakage current monitoring device of ZnO surge arresters is more highly sensitive and gives more linear response than the existing devices using the detection method of the third harmonic leakage currents. Therefore, the proposed leakage current monitoring device can be useful for predicting the defects and performance deterioration of ZnO surge arresters in power system applications

  8. Assessment of surge arrester failure rate and application studies in Hellenic high voltage transmission lines

    Energy Technology Data Exchange (ETDEWEB)

    Christodoulou, C.A.; Fotis, G.P.; Gonos, I.F.; Stathopulos, I.A. [National Technical University of Athens, School of Electrical and Computer Engineering, High Voltage Laboratory, 9 Iroon Politechniou St., Zografou Campus, 157 80 Athens (Greece); Ekonomou, L. [A.S.PE.T.E. - School of Pedagogical and Technological Education, Department of Electrical Engineering Educators, N. Heraklion, 141 21 Athens (Greece)

    2010-02-15

    The use of transmission line surge arresters to improve the lightning performance of transmission lines is becoming more common. Especially in areas with high soil resistivity and ground flash density, surge arresters constitute the most effective protection mean. In this paper a methodology for assessing the surge arrester failure rate based on the electrogeometrical model is presented. Critical currents that exceed arresters rated energy stress were estimated by the use of a simulation tool. The methodology is applied on operating Hellenic transmission lines of 150 kV. Several case studies are analyzed by installing surge arresters on different intervals, in relation to the region's tower footing resistance and the ground flash density. The obtained results are compared with real records of outage rate showing the effectiveness of the surge arresters in the reduction of the recorded failure rate. The presented methodology can be proved valuable to the studies of electric power systems designers intending in a more effective lightning protection, reducing the operational costs and providing continuity of service. (author)

  9. Parameter sensitivity and uncertainty analysis for a storm surge and wave model

    Directory of Open Access Journals (Sweden)

    L. A. Bastidas

    2016-09-01

    Full Text Available Development and simulation of synthetic hurricane tracks is a common methodology used to estimate hurricane hazards in the absence of empirical coastal surge and wave observations. Such methods typically rely on numerical models to translate stochastically generated hurricane wind and pressure forcing into coastal surge and wave estimates. The model output uncertainty associated with selection of appropriate model parameters must therefore be addressed. The computational overburden of probabilistic surge hazard estimates is exacerbated by the high dimensionality of numerical surge and wave models. We present a model parameter sensitivity analysis of the Delft3D model for the simulation of hazards posed by Hurricane Bob (1991 utilizing three theoretical wind distributions (NWS23, modified Rankine, and Holland. The sensitive model parameters (of 11 total considered include wind drag, the depth-induced breaking γB, and the bottom roughness. Several parameters show no sensitivity (threshold depth, eddy viscosity, wave triad parameters, and depth-induced breaking αB and can therefore be excluded to reduce the computational overburden of probabilistic surge hazard estimates. The sensitive model parameters also demonstrate a large number of interactions between parameters and a nonlinear model response. While model outputs showed sensitivity to several parameters, the ability of these parameters to act as tuning parameters for calibration is somewhat limited as proper model calibration is strongly reliant on accurate wind and pressure forcing data. A comparison of the model performance with forcings from the different wind models is also presented.

  10. Rapid wave and storm surge warning system for tropical cyclones in Mexico

    Science.gov (United States)

    Appendini, C. M.; Rosengaus, M.; Meza, R.; Camacho, V.

    2015-12-01

    The National Hurricane Center (NHC) in Miami, is responsible for the forecast of tropical cyclones in the North Atlantic and Eastern North Pacific basins. As such, Mexico, Central America and Caribbean countries depend on the information issued by the NHC related to the characteristics of a particular tropical cyclone and associated watch and warning areas. Despite waves and storm surge are important hazards for marine operations and coastal dwellings, their forecast is not part of the NHC responsibilities. This work presents a rapid wave and storm surge warning system based on 3100 synthetic tropical cyclones doing landfall in Mexico. Hydrodynamic and wave models were driven by the synthetic events to create a robust database composed of maximum envelops of wind speed, significant wave height and storm surge for each event. The results were incorporated into a forecast system that uses the NHC advisory to locate the synthetic events passing inside specified radiuses for the present and forecast position of the real event. Using limited computer resources, the system displays the information meeting the search criteria, and the forecaster can select specific events to generate the desired hazard map (i.e. wind, waves, and storm surge) based on the maximum envelop maps. This system was developed in a limited time frame to be operational in 2015 by the National Hurricane and Severe Storms Unit of the Mexican National Weather Service, and represents a pilot project for other countries in the region not covered by detailed storm surge and waves forecasts.

  11. The Role of LRRK2 in Parkinson's Disease

    NARCIS (Netherlands)

    A. Di Fonzo (Alessio)

    2009-01-01

    textabstractThis thesis focuses on the role of the leucine rich repeat kinase 2 (LRRK2) gene in Parkinson’s disease (PD). PD is the second most frequent human neurodegenerative disorder after Alzheimer’s disease. The etiology of PD remains unknown in most cases, but several

  12. motor and non-motor features of parkinson's disease

    African Journals Online (AJOL)

    2008-01-01

    Jan 1, 2008 ... Background: Parkinson's disease (PD) is a common neurodegenerative brain disease in developed countries where population of the elderly is high. PD is increasingly being documented in developing countries where there are rapid demographic changes. Motor features of PD have been documented in ...

  13. Multiple use of disposable (tubing) set of HomeChoice automated peritoneal dialysis (APD) system in PD patients.

    Science.gov (United States)

    Wadhwa, N K; Cabralda, T; Suh, H; Cascio, C; Folz, B; LaVeglia, C; Stratos, J

    1996-01-01

    Our objective was to evaluate the multiple use of the tubing set of the HomeChoice automated peritoneal dialysis (PD) system in PD patients. The study was designed to reuse the tubing set of the HomeChoice automated PD system for two to seven treatments, each of 16-24 hours duration, in end-stage renal disease (ESRD) patients, and to continue to use the same set if the patient was disconnected for any reason. In a tertiary-referral university hospital, 17 ESRD patients on PD, admitted to a university hospital from January, 1995 to September, 1995, were studied. The patients were disconnected and connected in between or during PD treatments. Five-liter bags were used. All the fluid was either set initially or added as clinically indicated. One hundred and thirty-eight PD treatments were performed with the HomeChoice automated PD system, using 30 disposable (tubing) sets. Sixty-three disconnections were made for ambulation, transfer to other units, surgery, physical therapy, radiological investigations, and special procedures in between and during PD treatments. No episode of peritonitis occurred. The multiple use resulted in a 78% reduction in tubing sets and drain-line extension sets used, thereby reducing the disposable supplies and creating a substantial saving in nursing time. The multiple use of tubing sets of the HomeChoice automated PD system was safe and economical in patients undergoing automated PD in a hospital setting.

  14. Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer.

    Science.gov (United States)

    Aust, Stefanie; Felix, Sophie; Auer, Katharina; Bachmayr-Heyda, Anna; Kenner, Lukas; Dekan, Sabine; Meier, Samuel M; Gerner, Christopher; Grimm, Christoph; Pils, Dietmar

    2017-03-07

    Immune-evasion and immune checkpoints are promising new therapeutic targets for several cancer entities. In ovarian cancer, the clinical role of programmed cell death receptor ligand 1 (PD-L1) expression as mechanism to escape immune recognition has not been clarified yet. We analyzed PD-L1 expression of primary ovarian and peritoneal tumor tissues together with several other parameters (whole transcriptomes of isolated tumor cells, local and systemic immune cells, systemic cytokines and metabolites) and compared PD-L1 expression between primary tumor and tumor recurrences. All expressed major histocompatibility complex (MHC) I genes were negatively correlated to PD-L1 abundances on tumor tissues, indicating two mutually exclusive immune-evasion mechanisms in ovarian cancer: either down-regulation of T-cell mediated immunity by PD-L1 expression or silencing of self-antigen presentation by down-regulation of the MHC I complex. In our cohort and in most of published evidences in ovarian cancer, low PD-L1 expression is associated with unfavorable outcome. Differences in immune cell populations, cytokines, and metabolites strengthen this picture and suggest the existence of concurrent pathways for progression of this disease. Furthermore, recurrences showed significantly increased PD-L1 expression compared to the primary tumors, supporting trials of checkpoint inhibition in the recurrent setting.

  15. Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease

    DEFF Research Database (Denmark)

    Manthripragada, Angelika D; Schernhammer, Eva S; Qiu, Jiaheng

    2011-01-01

    Experimental evidence supports a preventative role for non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease (PD).......Experimental evidence supports a preventative role for non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease (PD)....

  16. ISSN 2073-9990 East Cent Afr J Surg

    African Journals Online (AJOL)

    disease. Conclusions: Bladder carcinomas, BPH, ureteric obstruction are the commonest causes of obstructive nephropathy in our practice. The initial treatment includes urinary diversion and or dialysis before definitive treatment. Keywords: obstructive nephropathy, bladder cancer, acute kidney injury, chronic kidney injury,.

  17. ISSN 2073-9990 East Cent. Afr. J. surg. (Online)

    African Journals Online (AJOL)

    Hp 630 Dual Core

    Duodenal. Perforations .... 'ˆ …' '”„‹†‹–›. Keywords: gastro duodenal perforations, perforated peptic ulcer disease, gastric perforations ... predetermined outcomes using Chi square and fisherss exact test were used to detect statistical significance ...

  18. Clinical patterns in Parkinson's disease

    NARCIS (Netherlands)

    Rooden, Stephanie Maria van

    2012-01-01

    The clinical heterogeneity of Parkinson’s disease (PD) patients may reflect the existence of subtypes of the disease. PD subtypes have often been defined by a classification according to researcher-specified criteria, such as age-at-onset or predominant clinical motor features. The general objective

  19. Risks of Coastal Storm Surge and the Effect of Sea Level Rise in the Red River Delta, Vietnam

    OpenAIRE

    Neumann, James; Ludwig, Lindsay; Verly, Caroleen; Emanuel, Kerry Andrew; Ravela, Srinivas

    2015-01-01

    This paper considers the impact of sea level rise and storm surge on the Red River delta region of Vietnam an area already known to be highly vulnerable to coastal risks. By combining a range of sea level rise scenarios for 2050 with the simulated storm surge level for the 100-year storm surge, we analyze permanently inundated lands and temporary flood zones. As is well-established in the literature, sea level rise will increase the risk of storms by raising the base sea level from which surg...

  20. Reduction of the visual impact of overhead transmission line systems through utilisation of line surge arresters as lightning protection

    DEFF Research Database (Denmark)

    Sørensen, Thomas Kjærsgaard; Holbøll, Joachim

    2008-01-01

    in line performance and lightning protection of the nearest substations requires thorough modelling of the new line including all electrical parameters necessary for performance evaluation under all conditions. In this paper, explicit use of line surge arresters as lightning protection on the line...... of the line and the required protection level in substations. The use of line surge arresters gives the possibility to decrease the height of towers thereby improving the visual impression of the overhead line transmission systems. However the usage of line surge arresters will, dependent upon line surge...

  1. Parkinson Disease: Treating Symptoms Unrelated to Muscle Movement

    Science.gov (United States)

    ... It is a common nervous system disease in older adults. Younger adults sometimes develop PD. However, it rarely ... is common for men with PD to experience erectile dysfunction (ED), where there is difficulty having or maintaining ...

  2. Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders.

    Science.gov (United States)

    Huang, Jing; Zhuo, Wenyan; Zhang, Yuhu; Sun, Hongchun; Chen, Huan; Zhu, Peipei; Pan, Xiaobo; Yang, Jianhao; Wang, Lijuan

    2017-01-01

    Objective . The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods . Consecutive patients with PD ( n = 96), patients with primary sleep disorders ( n = 76), and healthy control subjects ( n = 66) were assessed. The patients with PD were classified into sleep disorder (PD-SD) and non-sleep disorder (PD-NSD) groups. Results . Among 96 patients with PD, 69 were diagnosed with a sleep disorder. There were 38 sleep disorder cases, 31 RBD cases, and 27 NSD cases. On the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and MoCA subtests, patients in the PD-SD, primary sleep disorder, and PD-NSD groups exhibited lower scores than those in the control group. Moreover, the PD-SD patients exhibited more significant cognitive impairment than was observed in the primary sleep disorder patients. In the PD-SD subgroup, the attention scores on the MoCA and on MoCA subtests were lower in the PD with RBD group than in the PD with insomnia group. Conclusion . PD with sleep disorders may exacerbate cognitive dysfunction in patients. PD associated with different types of sleep disorders differentially affects cognitive functions, and patients with PD with RBD exhibited poorer cognitive function than was seen in patients with PD with insomnia.

  3. Treatment outcome of PD-1 immune checkpoint inhibitor in Asian metastatic melanoma patients: correlative analysis with PD-L1 immunohistochemistry.

    Science.gov (United States)

    Cho, Jinhyun; Ahn, Soomin; Yoo, Kwai Han; Kim, Jung Han; Choi, Sang-Hee; Jang, Kee-Taek; Lee, Jeeyun

    2016-12-01

    Overexpression of PD-L1 has been shown to be associated with better clinical responses to PD-1/PD-L1 blockade in melanoma. However, the utility of PD-L1 immunostaining as a predictive biomarker for anti-PD-1 treatment remains unclear, especially in melanoma of acral/mucosal origin. Materials and methods We collected and reviewed the medical records of 37 patients with metastatic melanoma who were treated with the anti-PD-1 antibodies pembrolizumab or nivolumab between January and December 2015. Patients with histologically diagnosed malignant melanoma and whose pretreatment tumor specimens were available for immunohistochemical staining of PD-L1 expression in tumor or immune cells were included. Results Of 37 patients, 26 patients had either acral or mucosal melanoma. The overall response rate was 10.8 % (95 % CI, 0.8-20.8 %). The response rate to PD-1 inhibitor was 11.5 % (95 % CI, 0-23.8 %) in acral/mucosal melanoma and that for cutaneous melanoma was 9.1 % (95 % CI, 0-26.1 %). Of these 37 patients, 18 had pre-treatment tumor specimens available for PD-L1 staining. Of 18 patients, 10 (55.5 %) were of acral/mucosal origin. In all patients with acral melanoma, the overall response rate (ORR) was 16.7 % (1 of 6 patients) and disease control rate (DCR) was 50 % (3 of 6 patients). In the PDL-1(+) melanoma group (1 % cut-off value), ORR was 20 % (2/10) and DCR was 80 %; for PDL-1 (-) group, ORR was 12.5 % (1/8) and DCR of 37.5 %. In the PDL-1 (+) group by 5 % cut-off value, ORR was 33.3 % (2/6) and DCR was 83.3 %; for patients with PDL-1 (-), ORR was 8.3 % (1/12) and DCR was 50 %. The median PFS was 6.8 months in PDL-1(+) group and 1.9 months in PDL-1(-) group (p = 0.149). Anti-PD-1 treatment was very well tolerated without serious adverse events of grade 3 or 4 in all patients. Conclusions The treatment outcome to PD-1 antibody was not different in acral/mucosal melanoma when compared with cutaneous melanoma. The immunohistochemical PD-L1

  4. Storm surges-An option for Hamburg, Germany, to mitigate expected future aggravation of risk

    International Nuclear Information System (INIS)

    Storch, Hans von; Goennert, Gabriele; Meine, Manfred

    2008-01-01

    Summary: Rising sea level together with regionally increased storm activity, caused by elevated and increasing levels of greenhouse gases in the atmosphere will in many parts of the world increase the risk of storm surges significantly. Reducing the emissions of greenhouse gases into the atmosphere may mitigate the increasing risks somewhat, but the major task for regional and local stakeholders will be to prepare for appropriate adaptation. In most cases, possible strategies include intensification of coastal defense measures, in particular strengthening dykes, and adaptation to intermittent flooding. In case of Hamburg and the tidal Elbe river a third option seems to be available, which aims at mitigating storm surge risks by applying estuary engineering constructions. This option is sketched in this paper. The option has the potential to significantly reduce the expected future increases of local surge heights

  5. An Exploration of Wind Stress Calculation Techniques in Hurricane Storm Surge Modeling

    Directory of Open Access Journals (Sweden)

    Kyra M. Bryant

    2016-09-01

    Full Text Available As hurricanes continue to threaten coastal communities, accurate storm surge forecasting remains a global priority. Achieving a reliable storm surge prediction necessitates accurate hurricane intensity and wind field information. The wind field must be converted to wind stress, which represents the air-sea momentum flux component required in storm surge and other oceanic models. This conversion requires a multiplicative drag coefficient for the air density and wind speed to represent the air-sea momentum exchange at a given location. Air density is a known parameter and wind speed is a forecasted variable, whereas the drag coefficient is calculated using an empirical correlation. The correlation’s accuracy has brewed a controversy of its own for more than half a century. This review paper examines the lineage of drag coefficient correlations and their acceptance among scientists.

  6. Dynamic Model of Centrifugal Compressor for Prediction of Surge Evolution and Performance Variations

    International Nuclear Information System (INIS)

    Jung, Mooncheong; Han, Jaeyoung; Yu, Sangseok

    2016-01-01

    When a control algorithm is developed to protect automotive compressor surges, the simulation model typically selects an empirically determined look-up table. However, it is difficult for a control oriented empirical model to show surge characteristics of the super charger. In this study, a dynamic supercharger model is developed to predict the performance of a centrifugal compressor under dynamic load follow-up. The model is developed using Simulink® environment, and is composed of a compressor, throttle body, valves, and chamber. Greitzer’s compressor model is used, and the geometric parameters are achieved by the actual supercharger. The simulation model is validated with experimental data. It is shown that compressor surge is effectively predicted by this dynamic compressor model under various operating conditions.

  7. Experimental Study on Active Control of Surge in a Centrifugal Compression System

    Directory of Open Access Journals (Sweden)

    Nie Chaoqun

    2000-01-01

    Full Text Available An experimental study has been carried out on the active control of surge in a centrifugal compression system. With a computerized on-line control scheme, the surge phenomenon is suppressed and the stable operating range of the system is extended. In order to design the active control scheme and choose the desired parameters of the control system inputs, special emphases have been placed on the development of surge inception and the nonlinear interaction between the system and the actuator. By use of the method designed in the present work, the results of active control onsurge have been demonstrated for the different B parameters, different prescribed criteria and different control frequencies.

  8. On Active Surge Control of Compression Systems via Characteristic Linearization and Model Nonlinearity Cancellation

    Directory of Open Access Journals (Sweden)

    Yohannes S.M. Simamora

    2014-09-01

    Full Text Available A simple approach of active surge control of compression systems is presented. Specifically, nonlinear components of the pressure ratio and rotating speed states of the Moore-Greitzer model are transferred into the input vectors. Subsequently, the compressor characteristic is linearized into two modes, which describe the stable region and the unstable region respectively. As a result, the system’s state and input matrices both appear linear, to which linear realization and analysis are applicable. A linear quadratic regulator plus integrator is then chosen as closed-loop controller. By simulation it was shown that the modified model and characteristics can describe surge behavior, while the closed-loop controller can stabilize the system in the unstable operating region. The last-mentioned was achieved when massflow was 5.38 per cent less than the surge point.

  9. Parameter identification of ZnO surge arrester models based on genetic algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Bayadi, Abdelhafid [Laboratoire d' Automatique de Setif, Departement d' Electrotechnique, Faculte des Sciences de l' Ingenieur, Universite Ferhat ABBAS de Setif, Route de Bejaia Setif 19000 (Algeria)

    2008-07-15

    The correct and adequate modelling of ZnO surge arresters characteristics is very important for insulation coordination studies and systems reliability. In this context many researchers addressed considerable efforts to the development of surge arresters models to reproduce the dynamic characteristics observed in their behaviour when subjected to fast front impulse currents. The difficulties with these models reside essentially in the calculation and the adjustment of their parameters. This paper proposes a new technique based on genetic algorithm to obtain the best possible series of parameter values of ZnO surge arresters models. The validity of the predicted parameters is then checked by comparing the predicted results with the experimental results available in the literature. Using the ATP-EMTP package, an application of the arrester model on network system studies is presented and discussed. (author)

  10. Adjusting the Parameters of Metal Oxide Gapless Surge Arresters’ Equivalent Circuits Using the Harmony Search Method

    Directory of Open Access Journals (Sweden)

    Christos A. Christodoulou

    2017-12-01

    Full Text Available The appropriate circuit modeling of metal oxide gapless surge arresters is critical for insulation coordination studies. Metal oxide arresters present a dynamic behavior for fast front surges; namely, their residual voltage is dependent on the peak value, as well as the duration of the injected impulse current, and should therefore not only be represented by non-linear elements. The aim of the current work is to adjust the parameters of the most frequently used surge arresters’ circuit models by considering the magnitude of the residual voltage, as well as the dissipated energy for given pulses. In this aim, the harmony search method is implemented to adjust parameter values of the arrester equivalent circuit models. This functions by minimizing a defined objective function that compares the simulation outcomes with the manufacturer’s data and the results obtained from previous methodologies.

  11. Availability of a pediatric trauma center in a disaster surge decreases triage time of the pediatric surge population: a population kinetics model

    Directory of Open Access Journals (Sweden)

    Grikscheit Tracy C

    2011-10-01

    Full Text Available Abstract Background The concept of disaster surge has arisen in recent years to describe the phenomenon of severely increased demands on healthcare systems resulting from catastrophic mass casualty events (MCEs such as natural disasters and terrorist attacks. The major challenge in dealing with a disaster surge is the efficient triage and utilization of the healthcare resources appropriate to the magnitude and character of the affected population in terms of its demographics and the types of injuries that have been sustained. Results In this paper a deterministic population kinetics model is used to predict the effect of the availability of a pediatric trauma center (PTC upon the response to an arbitrary disaster surge as a function of the rates of pediatric patients' admission to adult and pediatric centers and the corresponding discharge rates of these centers. We find that adding a hypothetical pediatric trauma center to the response documented in an historical example (the Israeli Defense Forces field hospital that responded to the Haiti earthquake of 2010 would have allowed for a significant increase in the overall rate of admission of the pediatric surge cohort. This would have reduced the time to treatment in this example by approximately half. The time needed to completely treat all children affected by the disaster would have decreased by slightly more than a third, with the caveat that the PTC would have to have been approximately as fast as the adult center in discharging its patients. Lastly, if disaster death rates from other events reported in the literature are included in the model, availability of a PTC would result in a relative mortality risk reduction of 37%. Conclusions Our model provides a mathematical justification for aggressive inclusion of PTCs in planning for disasters by public health agencies.

  12. A high resolution study of a hurricane storm surge and inundation in Veracruz, Mexico

    Science.gov (United States)

    Díaz García, Ovel; Zavala Hidalgo, Jorge; Douillet, Pascal

    2014-05-01

    Veracruz is the most populated city along the Mexican shoreline of the Gulf of Mexico and also is the country's largest commercial port. In recent years the city has been affected by hurricanes of medium intensity that have provoked human casualties, property damaged and economic loss. Two of the most recent events were hurricane Karl (2010), which caused a storm surge and severe flooding, and hurricane Ernesto (2012). The purpose of this work is to study, based on high-resolution numerical simulations, scenarios of storm surge flooding using state-of-the-art open source numerical models: the Weather, Research and Forecasting (WRF), and the coupled models ADvanced CIRCulation (ADCIRC) and Simulating WAves Nearshore (SWAN) for weather and storm surge hindcast, respectively. We also use topography high resolution data from LIDAR and bathymetry from GEBCO 30", the Mexican Navy and nautical charts from Electrical Federal Commission. We present the validation of the models evaluating several statistical parameters against measurements from Acoustic Data Current Profilers, pressure sensors, tide gauge and meteorological stations for these events. In the case of hurricane Karl, it made landfall 15 km north of Veracruz City, reducing the maximum surge along the city shoreline. The hurricane Ernesto made landfall 200 km southeast of the city, too far to have a significant impact. We did some numerical experiments slightly changing the trajectory, reported by the best track data, for these two hurricanes with the purpose of evaluating storm surge scenarios. The results shows that the worst storm surge cases were when the tracks of this hurricanes made landfall south of the city in the range of 30 to 60 km.

  13. Health Systems’ “Surge Capacity”: State of the Art and Priorities for Future Research

    Science.gov (United States)

    Watson, Samantha K; Rudge, James W; Coker, Richard

    2013-01-01

    Context Over the past decade, a number of high-impact natural hazard events, together with the increased recognition of pandemic risks, have intensified interest in health systems’ ability to prepare for, and cope with, “surges” (sudden large-scale escalations) in treatment needs. In this article, we identify key concepts and components associated with this emerging research theme. We consider the requirements for a standardized conceptual framework for future research capable of informing policy to reduce the morbidity and mortality impacts of such incidents. Here our objective is to appraise the consistency and utility of existing conceptualizations of health systems’ surge capacity and their components, with a view to standardizing concepts and measurements to enable future research to generate a cumulative knowledge base for policy and practice. Methods A systematic review of the literature on concepts of health systems’ surge capacity, with a narrative summary of key concepts relevant to public health. Findings The academic literature on surge capacity demonstrates considerable variation in its conceptualization, terms, definitions, and applications. This, together with an absence of detailed and comparable data, has hampered efforts to develop standardized conceptual models, measurements, and metrics. Some degree of consensus is evident for the components of surge capacity, but more work is needed to integrate them. The overwhelming concentration in the United States complicates the generalizability of existing approaches and findings. Conclusions The concept of surge capacity is a useful addition to the study of health systems’ disaster and/or pandemic planning, mitigation, and response, and it has far-reaching policy implications. Even though research in this area has grown quickly, it has yet to fulfill its potential to generate knowledge to inform policy. Work is needed to generate robust conceptual and analytical frameworks, along with

  14. Quantification of Storm Surge Using A Python-based ArcGIS Toolbox

    Science.gov (United States)

    Gao, S.; Siverd, C. G.; Bilskie, M. V.; Hagen, S. C.; Alizad, K.

    2016-12-01

    Geographic Information System (GIS) technology allows the organization, manipulation, analysis, and visualization of spatial data (Fischer, 2010). Although GIS provides some operations for spatial analysis, the methods are often only partially implemented and can be difficult to find and use effectively (Rigol-Sanchez et al., 2015). For coastal researchers, development of automated GIS tools is essential to efficiently analyze coastal flood risk from hurricanes. An adaptive GIS toolbox, Quantitative Surge Analysis Tool (QSAT), was developed and implements ArcGIS software and Python scripts to quantify attributes of hurricane storm surge (e.g., average water surface elevation). The python script provides a way to allow researchers to reduce the amount of time spent developing common solutions (Etherington, 2010) and repeating manual operations. The QSAT contains tools that run in the ArcGIS program. These tools compute average water surface elevation, average inundation depth, inundated area, total surge volume, percent of land inundated, and retention time for a given polygonal area. A new shapefile is created with a detail attribute table containing the various surge quantities. The toolbox is designed to directly read data files produced by an ADCIRC storm surge simulation as well as a polygon shapefile defining the areas of interest. The functionality of the QSAT toolbox was tested using Hydrologic Unit Code 12 (HUC 12) polygons of coastal Louisiana and ADCIRC model results from a simulation of Hurricane Gustav. The QSAT aids a streamlined transition of surge quantities across a local medium (i.e. HUC 12s) to better inform stakeholders and lead to improved regional and local decisions.

  15. Automating Flood Hazard Mapping Methods for Near Real-time Storm Surge Inundation and Vulnerability Assessment

    Science.gov (United States)

    Weigel, A. M.; Griffin, R.; Gallagher, D.

    2015-12-01

    Storm surge has enough destructive power to damage buildings and infrastructure, erode beaches, and threaten human life across large geographic areas, hence posing the greatest threat of all the hurricane hazards. The United States Gulf of Mexico has proven vulnerable to hurricanes as it has been hit by some of the most destructive hurricanes on record. With projected rises in sea level and increases in hurricane activity, there is a need to better understand the associated risks for disaster mitigation, preparedness, and response. GIS has become a critical tool in enhancing disaster planning, risk assessment, and emergency response by communicating spatial information through a multi-layer approach. However, there is a need for a near real-time method of identifying areas with a high risk of being impacted by storm surge. Research was conducted alongside Baron, a private industry weather enterprise, to facilitate automated modeling and visualization of storm surge inundation and vulnerability on a near real-time basis. This research successfully automated current flood hazard mapping techniques using a GIS framework written in a Python programming environment, and displayed resulting data through an Application Program Interface (API). Data used for this methodology included high resolution topography, NOAA Probabilistic Surge model outputs parsed from Rich Site Summary (RSS) feeds, and the NOAA Census tract level Social Vulnerability Index (SoVI). The development process required extensive data processing and management to provide high resolution visualizations of potential flooding and population vulnerability in a timely manner. The accuracy of the developed methodology was assessed using Hurricane Isaac as a case study, which through a USGS and NOAA partnership, contained ample data for statistical analysis. This research successfully created a fully automated, near real-time method for mapping high resolution storm surge inundation and vulnerability for the

  16. PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics.

    Science.gov (United States)

    Massi, D; Brusa, D; Merelli, B; Ciano, M; Audrito, V; Serra, S; Buonincontri, R; Baroni, G; Nassini, R; Minocci, D; Cattaneo, L; Tamborini, E; Carobbio, A; Rulli, E; Deaglio, S; Mandalà, M

    2014-12-01

    Programmed cell death ligand 1 (PD-L1) is a cell surface molecule that plays a critical role in suppressing immune responses, mainly through binding of the PD-1 receptor on T lymphocytes. PD-L1 may be expressed by metastatic melanoma (MM). However, its clinical and biological significance remains unclear. Here, we investigated whether expression of PD-L1 in MM identifies a biologically more aggressive form of the disease, carrying prognostic relevance. PD-L1 expression was analyzed by immunohistochemistry using two different antibodies in primary tumors and paired metastases from 81 melanoma patients treated at a single institution. Protein expression levels were correlated with PD-L1 mRNA, BRAF mutational status and clinical outcome. PD-L1(+) and PD-L1(-) subsets of the A375 cell line were stabilized in vitro and compared using gene expression profiling and functional assays. Results were confirmed using xenograft models. PD-L1 membrane positivity was detected in 30/81 (37%) of patients. By multivariate analysis, Breslow thickness and PD-L1 membrane positivity were independent risk factors for melanoma-specific death {PD-L1 5% cutoff [hazard ratio (HR) 3.92, confidence interval (CI) 95% 1.61-9.55 P melanoma. If confirmed, our clinical and experimental data suggest that PD-L1(+) melanomas should be considered a disease subset with distinct genetic and morpho-phenotypic features, leading to enhanced aggressiveness and invasiveness. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  17. From the "PD First" policy to the innovation in PD care.

    Science.gov (United States)

    Treamtrakanpon, Worapot; Katavetin, Pisut; Yimsangyad, Khanittha; Keawsinark, Pasunun; Sanganunttakan, Suthasinee; Pandon, Sukannika; Buddeewong, Darunee; Prakot, Auengpha; Khumsupo, Chanpen; Thamsutee, Noppadon; Yaibuaiam, Ranu; Khumwong, Sawida; Towannang, Piyaporn; Theerasin, Yuwadee; Mahatnan, Nanta; Eiam-Ong, Somchai; Kanjanabuch, Talerngsak

    2011-09-01

    Due to the rapid growth of peritoneal dialysis (PD) program under the "PD First" policy of Thailand, it is necessary to have many voluntary well-training PD staffs and a good education program for PD nurses to serve an excellent PD outcome. In the present study novel devices, which could be practically used in PD patients, were developed by the creative PD trainee idea of to facilitate PD self-care and decrease work load of PD staffs. Young PD nurses in the 3rd generation of PD trainee program from King Chulalongkorn Memorial Hospital were assigned to develop novel tools in order to assisting patient care in real practice. The efficacy of these inventions and patient satisfaction were assessed by comparing with the standard method. The authors presented two interesting innovations in the present study. The first one, "Troubleshooting Wheel", contained six common complaints and the advice for correcting each problem in the platform of rotating wheel. Participants could solve problems more rapidly than using the standard handbook for PD (p Abacus", the sliding platform with automatic calculation of the sum of exit site score, was the easier method in evaluating the exit site infection than the conventional exit site scoring using the Prowant's table or their own memory. Reinforcement of the development of PD nursing program not only increases the number of PD staffs but also contributes to the innovations for improving quality of PD care by the young new staffs.

  18. Factors guiding tsunami surge at the Nagapattinam–Cuddalore shelf, Tamil Nadu, east coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Murthy, K.S.R.; Subrahmanyam, A.S.; Murty, G.P.S.; Sarma, K.V.L.N.S.; Subrahmanyam, V.; Rao, K.M.; Rani, P.S.; Anuradha, A.; Adilakshmi, B.; Devi, T.S.

    , India The Tamil Nadu margin, in particular the Nagapatt i- nam ? Cuddalore shelf was the worst affected by the ts u nami surge and inundation caused by the great Sumatra eart h quake of 26 December 2004 ( M w 9.3). Surge heights in this part...., Scientist issue I n- donesia earthquake warning. Nature , 2005, 434 , 291. 3. Satish Singh, Disastrous Sumatra earthquake: Sea monster ? a post - mortem mitigation study for future mega - thrust eart h quake in the Indian Ocean. Paper presented...

  19. Impacts of Storm Surge Mitigation Strategies on Aboveground Storage Tank Chemical Spill Transport

    Science.gov (United States)

    Do, C.; Bass, B. J.; Bernier, C.; Samii, A.; Dawson, C.; Bedient, P. B.

    2017-12-01

    The Houston Ship Channel (HSC), located in the hurricane-prone Houston-Galveston region of the upper Texas Coast, is one of the busiest waterways in the United States and is home to one of the largest petrochemical complexes in the world. Due to the proximity of the HSC to Galveston Bay and the Gulf of Mexico, chemical spills resulting from storm surge damage to aboveground storage tanks (ASTs) pose serious threats to the environment, residential communities, and national/international markets whose activities in the HSC generate billions of dollars annually. In an effort to develop a comprehensive storm surge mitigation strategy for Galveston Bay and its constituents, Rice University's Severe Storm Prediction, Education, and Evacuation from Disasters Center proposed two structural storm surge mitigation concepts, the Mid Bay Structure (MBS) and the Lower Bay Structure (LBS) as components of the Houston-Galveston Area Protection System (H-GAPS) project. The MBS consists of levees along the HSC and a navigational gate across the channel, and the LBS consists of a navigation gate and environmental gates across Bolivar Road. The impacts of these two barrier systems on the fate of AST chemical spills in the HSC have previously been unknown. This study applies the coupled 2D SWAN+ADCIRC model to simulate hurricane storm surge circulation within the Gulf of Mexico and Galveston Bay due to a synthetic storm which results in approximately 250-year surge levels in Galveston Bay. The SWAN+ADCIRC model is run using high-resolution computational meshes that incorporate the MBS and LBS scenarios, separately. The resulting wind and water velocities are then fed into a Lagrangian particle transport model to simulate the spill trajectories of the ASTs most likely to fail during the 250-year proxy storm. Results from this study illustrate how each storm surge mitigation strategy impacts the transport of chemical spills (modeled as Lagrangian particles) during storm surge as

  20. Surge voltages and currents into a customer due to nearby lightning

    Energy Technology Data Exchange (ETDEWEB)

    Ametani, Akihiro; Matsuoka, Kae [Power System Analysis Laboratory, Doshisha University, Kyo-tanabe, Kyoto 610-0321 (Japan); Omura, Hiroshi; Nagai, Yoshiyuki [Power Engineering R and D Center, Kansai Electric Power Co., Amagasaki, Osaka 661-0794 (Japan)

    2009-03-15

    This paper presents experimental results of lightning surges incoming into a customer due to lightning to an antenna of the customer, a pole and a ground nearby the customer, and briefly discusses lightning current distribution in the customer, a distribution line and a telephone line. Based on experimental results, modeling of each component is explained, and EMTP simulations are carried out. The ground voltage rise is represented by a mutual resistance between grounding electrodes. EMTP simulation results have been observed to agree qualitatively with the measured results, and it becomes possible to investigate lightning surges and current distribution in a customer by an EMTP simulation. (author)

  1. Principal component analysis of the summertime winds over the Gulf of California: A gulf surge index

    OpenAIRE

    Bordoni, S.; Stevens, B.

    2006-01-01

    A principal component analysis of the summertime near-surface Quick Scatterometer (QuikSCAT) winds is used to identify the leading mode of synoptic-scale variability of the low-level flow along the Gulf of California during the North American monsoon season. A gulf surge mode emerges from this analysis as the leading EOF, with the corresponding principal component time series interpretable as an objective index for gulf surge occurrence. This index is used as a reference time series for regre...

  2. Evaluation and comparison of the operational Bristol Channel Model storm surge suite

    OpenAIRE

    Williams, J.A.; Horsburgh, K.J.

    2013-01-01

    Due to its exceptional tidal range, complex geometry, and exposure to flood risk the operational storm surge modelling system for the Bristol Channel (running four times each day as part of the UK Coastal Monitoring and Forecasting service) comprises a number of nested hydrodynamic models. Forecasts for the region are available from the shelf-wide storm surge model, CS3X, as well as from two finer-scale models of the Bristol Channel itself (the Bristol Channel model, BCM, and the Severn River...

  3. Relationship between Postural Deformities and Frontal Function in Parkinson's Disease

    OpenAIRE

    Ninomiya, Satoko; Morita, Akihiko; Teramoto, Hiroko; Akimoto, Takayoshi; Shiota, Hiroshi; Kamei, Satoshi

    2015-01-01

    Postural deformities and executive dysfunction (ED) are common symptoms of Parkinson's disease (PD); however, the relationship between postural deformities and ED in patients with PD remains unclear. This study assessed the relationship between postural deformities and ED in patients with PD. Sixty-five patients with sporadic PD were assessed for the severity of postural deformities and executive function. The severity of postural deformities was scored using the United Parkinson's Disease Ra...

  4. Visual symptoms in Parkinson's disease and Parkinson's disease dementia.

    Science.gov (United States)

    Archibald, Neil K; Clarke, Mike P; Mosimann, Urs P; Burn, David J

    2011-11-01

    Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty-four subjects with PD, 26 with PD dementia, and 32 age-matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different "hallucinatory" experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia. Copyright © 2011 Movement Disorder Society.

  5. Empowering Patients: PD in Healthcare

    DEFF Research Database (Denmark)

    Kensing, Finn; Strand, Dixi Louise; Bansler, Jørgen P.

    2004-01-01

    empowerment as focus of ongoing research in the research program Health Care IT along with three empirical case studies under way. We conclude by highlighting the context-specific challenges development of new IT services in the health care sector poses and relate these challenges to existing PD concepts...

  6. Brief communication: The Khurdopin glacier surge revisited - extreme flow velocities and formation of a dammed lake in 2017

    Science.gov (United States)

    Steiner, Jakob F.; Kraaijenbrink, Philip D. A.; Jiduc, Sergiu G.; Immerzeel, Walter W.

    2018-01-01

    Glacier surges occur regularly in the Karakoram, but the driving mechanisms, their frequency and its relation to a changing climate remain unclear. In this study, we use digital elevation models and Landsat imagery in combination with high-resolution imagery from the Planet satellite constellation to quantify surface elevation changes and flow velocities during a glacier surge of the Khurdopin Glacier in 2017. Results reveal that an accumulation of ice volume above a clearly defined steep section of the glacier tongue since the last surge in 1999 eventually led to a rapid surge in May 2017 peaking with velocities above 5000 m a-1, which were among the fastest rates globally for a mountain glacier. Our data reveal that velocities on the lower tongue increase steadily during a 4-year build-up phase prior to the actual surge only to then rapidly peak and decrease again within a few months, which confirms earlier observations with a higher frequency of available velocity data. The surge return period between the reported surges remains relatively constant at ca. 20 years. We show the potential of a combination of repeat Planet and ASTER imagery to (a) capture peak surge velocities that are easily missed by less frequent Landsat imagery, (b) observe surface changes that indicate potential drivers of a surge and (c) monitor hazards associated with a surge. At Khurdopin specifically, we observe that the surging glacier blocks the river in the valley and causes a lake to form, which may grow in subsequent years and could pose threats to downstream settlements and infrastructure in the case of a sudden breach.

  7. Improvements of Storm Surge Modelling in the Gulf of Venice with Satellite Data: The ESA Due Esurge-Venice Project

    Science.gov (United States)

    De Biasio, F.; Bajo, M.; Vignudelli, S.; Papa, A.; della Valle, A.; Umgiesser, G.; Donlon, C.; Zecchetto, S.

    2016-08-01

    Among the most detrimental natural phenomena, storm surges heavily endanger the environment, the economy and the everyday life of sea-side countries and coastal zones. Considering that 120.000.000 people live in the Mediterranean area, with additional 200.000.000 presences in Summer for tourism purposes, the correct prediction of storm surges is crucial to avoid fatalities and economic losses. Earth Observation (EO) can play an important role in operational storm surge forecasting, yet it is not widely diffused in the storm surge community. In 2011 the European Space Agency (ESA), through its Data User Element (DUE) programme, financed two projects aimed at encouraging the uptake of EO data in this sector: eSurge and eSurge-Venice (eSV). The former was intended to address the issues of a wider users' community, while the latter was focused on a restricted geographical area: the northern Adriatic Sea and the Gulf of Venice. Among the objectives of the two projects there were a number of storm surge hindcast experiments using satellite data, to demonstrate the improvements on the surge forecast brought by EO. We report here the results of the hindcast experiments of the eSV project. They were aimed to test the sensitivity of a storm surge model to a forcing wind field modified with scatterometer data in order to reduce the bias between simulated and observed winds. Hindcast experiments were also performed to test the response of the storm surge model to the assimilation, with a dual 4D-Var system, of satellite altimetry observations as model errors of the initial state of the sea surface level. Remarkable improvements on the storm surge forecast have been obtained for what concerns the modified model wind forcing. Encouraging results have been obtained also in the assimilation experiments.

  8. PD-L1-specific T cells

    DEFF Research Database (Denmark)

    Ahmad, Shamaila Munir; Borch, Troels Holz; Hansen, Morten

    2016-01-01

    -specific T cells that recognize both PD-L1-expressing immune cells and malignant cells. Thus, PD-L1-specific T cells have the ability to modulate adaptive immune reactions by reacting to regulatory cells. Thus, utilization of PD-L1-derived T cell epitopes may represent an attractive vaccination strategy...... for targeting the tumor microenvironment and for boosting the clinical effects of additional anticancer immunotherapy. This review summarizes present information about PD-L1 as a T cell antigen, depicts the initial findings about the function of PD-L1-specific T cells in the adjustment of immune responses...

  9. ISSN 2073-9990 East Cent Afr J Surg

    African Journals Online (AJOL)

    Typhoid fever is a septicemic illness caused by the gram-negative bacillus Salmonella typhi, and constitutes a ... cause of mortality in about 25% to 40% of patients afflicted with this disease.3 Once perforation has occurred .... symptoms may develop, the Peyer's Patches (PP) in the distal ileum and the SILTs in the terminal.

  10. ISSN 2073-9990 East Cent Afr J Surg

    African Journals Online (AJOL)

    as an appendectomy or several episodes of pelvic inflammatory disease. The remaining documented causes of intestinal obstruction in pregnancy listed in descending frequency are volvulus (24%), intussusception (5%) and ileosigmoid knotting (3.2% to 5.9%).1,2,4,5. Ileosigmoid knotting (ISK), also known as compound ...

  11. ISSN 2073-9990 East Cent. Afr. J. surg. (Online)

    African Journals Online (AJOL)

    dell

    Background: Surgical abdominal emergencies constitute an entity of pathologies requiring immediate medical and surgical management in most of the cases. There is little information regarding the clinical spectrum of disease in these patients and the outcome after admission to hospital. This study was conducted at Kigali ...

  12. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    Background: Hemorrhoids are a common anorectal condition. New surgical treatments have led to a reappraisal of hemorrhoid disease over the last few decades and despite a range of treatment modalities, the options are limited in their effectiveness and can lead to a number of complications. This study set out to compare ...

  13. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    (Candida species), systemic leptospirosis, Vibrio cholera and clonorchis sinensis5. AAC has also been reported in patients with connective tissue disease5. The clinical presentation of AAC is variable and more so when it complicates. In one large single center report, 36 of 47 patients (77%) identified over a seven year ...

  14. ISSN 2073-9990 East Cent. Afr. J. surg. (Online)

    African Journals Online (AJOL)

    dell

    Cirugia Espanola 1999;66( Suppl 1):233. 16. David GG, Al-Sarira AA, Willmott S et al. Management of acute gallbladder disease in. England. British Journal Of Surgery 2008; 95: 472-476. 17. David W. Rattner, Charles Ferguson, Andrew L. Warshaw et al. Factors associated with. Successful Laparoscopic Cholecystectomy ...

  15. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    Rahima Dawood Travelling Fellow 2010. Critical care services often fall far outside the focus of mainstream health care agendas. The disease specific list held by many health care stakeholders, including the funding agencies, results in a funneling of political attention and funds predominantly in those directions. Infectious ...

  16. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    2014-10-31

    Oct 31, 2014 ... bone. Stage IV - Pain, acetabular disease with joint space narrowing and arthritis. (osteoarthrosis) visible on x-ray, abnormal MRI or bone scan findings. Spine osteonecrosis was diagnosed by clinical history of back pain and confirmed by radiological presentation of “fish mouth” vertebra which is a smooth ...

  17. Cortical hypometabolism and hypoperfusion in Parkinson's disease is extensive: probably even at early disease stages

    DEFF Research Database (Denmark)

    Borghammer, Per; Chakravarty, Mallar; Jonsdottir, Kristjana Yr

    2010-01-01

    independent samples of PD patients. We compared SPECT CBF images of 32 early-stage and 33 late-stage PD patients with that of 60 matched controls. We also compared PET FDG images from 23 late-stage PD patients with that of 13 controls. Three different normalization methods were compared: (1) GM normalization...... likely has widespread cortical hypometabolism, even at early disease stages. In contrast, extensive subcortical hypermetabolism is probably not a feature of PD....

  18. Excessive hoarding in Parkinson's disease.

    Science.gov (United States)

    O'Sullivan, Sean S; Djamshidian, Atbin; Evans, Andrew H; Loane, Clare M; Lees, Andrew J; Lawrence, Andrew D

    2010-06-15

    Hoarding is seen in several psychiatric conditions, but has not been specifically assessed in Parkinson's disease (PD). This study investigates hoarding tendency amongst patients with PD, and its association with impulsive-compulsive spectrum behaviors (ICBs). We compare clinical features, measures of hoarding, impulse buying, self-control, obsessive-compulsive symptoms, depression, and anxiety in 39 patients with PD with ICBs (PD + ICB), 61 patients with PD without ICBs (PD - ICB), and 50 healthy controls. A much higher proportion of PD + ICB (27.8%) than PD - ICB (3.5%) were hoarders (P = 0.001). 6% of healthy controls were hoarders. Compulsive shoppers scored higher than other varieties of ICB on excessive acquisition measures. Hoarding correlated positively with impulsive buying, obsessive-compulsive symptoms, PD duration, and negatively with self-control measures. Using multivariate regression analyzes, the presence of ICBs and measures of impulsive buying were the only variables independently associated with hoarding in PD. The association of hoarding with other ICBs and low trait impulse control suggests that excessive hoarding is related to the spectrum of impulsive behaviors in PD. (c) 2010 Movement Disorder Society.

  19. Periodontal disease and diabetes mellitus.

    Science.gov (United States)

    Negrato, Carlos Antonio; Tarzia, Olinda; Jovanovič, Lois; Chinellato, Luiz Eduardo Montenegro

    2013-01-01

    Periodontal disease (PD) is one of the most commonly known human chronic disorders. The relationship between PD and several systemic diseases such as diabetes mellitus (DM) has been increasingly recognized over the past decades. The purpose of this review is to provide the reader with knowledge concerning the relationship between PD and DM. Many articles have been published in the English and Portuguese literature over the last 50 years examining the relationship between these two chronic diseases. Data interpretation is often confounded by varying definitions of DM, PD and different clinical criteria were applied to determine the prevalence, extent and severity of PD, levels of glycemic control and diabetes-related complications. This paper provides a broad overview of the predominant findings from research conducted using the BBO (Bibliografia Brasileira de Odontologia), MEDLINE, LILACS and PubMed for Controlled Trials databases, in English and Portuguese languages published from 1960 to October 2012. Primary research reports on investigations of relationships between DM/DM control, PD/periodontal treatment and PD/DM/diabetes-related complications identified relevant papers and meta-analyses published in this period. This paper describes the relationship between PD and DM and answers the following questions: 1- The effect of DM on PD, 2- The effects of glycemic control on PD and 3- The effects of PD on glycemic control and on diabetes-related complications. The scientific evidence reviewed supports diabetes having an adverse effect on periodontal health and PD having an adverse effect on glycemic control and on diabetes-related complications. Further research is needed to clarify these relationships and larger, prospective, controlled trials with ethnically diverse populations are warranted to establish that treating PD can positively influence glycemic control and possibly reduce the burden of diabetes-related complications.

  20. Periodontal disease and diabetes mellitus

    Science.gov (United States)

    NEGRATO, Carlos Antonio; TARZIA, Olinda; JOVANOVIČ, Lois; CHINELLATO, Luiz Eduardo Montenegro

    2013-01-01

    Periodontal disease (PD) is one of the most commonly known human chronic disorders. The relationship between PD and several systemic diseases such as diabetes mellitus (DM) has been increasingly recognized over the past decades. Objective: The purpose of this review is to provide the reader with knowledge concerning the relationship between PD and DM. Many articles have been published in the english and Portuguese literature over the last 50 years examining the relationship between these two chronic diseases. Data interpretation is often confounded by varying definitions of DM, PD and different clinical criteria were applied to determine the prevalence, extent and severity of PD, levels of glycemic control and diabetes-related complications. Methods: This paper provides a broad overview of the predominant findings from research conducted using the BBO (Bibliografia Brasileira de Odontologia), MEDLINE, LILACS and PubMed for Controlled Trials databases, in english and Portuguese languages published from 1960 to October 2012. Primary research reports on investigations of relationships between DM/DM control, PD/periodontal treatment and PD/DM/diabetes-related complications identified relevant papers and meta-analyses published in this period. Results: This paper describes the relationship between PD and DM and answers the following questions: 1- The effect of DM on PD, 2- The effects of glycemic control on PD and 3- The effects of PD on glycemic control and on diabetes-related complications. Conclusions: The scientific evidence reviewed supports diabetes having an adverse effect on periodontal health and PD having an adverse effect on glycemic control and on diabetes-related complications. Further research is needed to clarify these relationships and larger, prospective, controlled trials with ethnically diverse populations are warranted to establish that treating PD can positively influence glycemic control and possibly reduce the burden of diabetes

  1. Parkinson's Disease: Is It a Toxic Syndrome?

    Directory of Open Access Journals (Sweden)

    Seham A. Gad ELhak

    2010-01-01

    Full Text Available Parkinson's disease (PD is one of the neurodegenerative diseases which we can by certainty identify its pathology, however, this confidence disappeares when talking about the cause. A long history of trials, suggestions, and theories tried linking PD to a specific causation. In this paper, a new suggestion is trying to find its way, could it be toxicology? Can we—in the future—look to PD as an occupational disease, in fact, many clues point to the possible toxic responsibility—either total or partial—in causing this disease. Searching for possible toxic causes for PD would help in designing perfect toxic models in animals.

  2. Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol

    OpenAIRE

    Meredith, Gloria E.; Totterdell, Susan; Potashkin, Judith A.; Surmeier, D. James

    2008-01-01

    Formidable challenges for Parkinson's disease (PD) research are to understand the processes underlying nigrostriatal degeneration and how to protect the dopamine neurons. Fundamental research relies on good animal models that demonstrate the pathological hallmarks and motor deficits of PD. Using a chronic regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid (MPTP/p) in mice, dopamine cell loss exceeds 60%, extracellular glutamate is elevated, cytoplasmic inclusions are forme...

  3. Parkinson's Disease: The Newest Advances

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Parkinson's Disease: The Newest Advances Past Issues / Summer 2006 Table ... number of genes that cause or contribute to Parkinson's disease (PD), as well as potential environmental risk factors. ...

  4. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Too Afraid to Ask Expert Briefings: What's Missing? Communication and the PD Partnership Expert Briefings: Fatigue, Sleep Disorders and Parkinson's Disease Expert Briefings: What's in the ...

  5. Parkinson's Disease Videos

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    Full Text Available ... Expert Briefings: Parkinson's Disease: Financial, Legal and Medical Planning Tips for Care Partners Nursing Solutions: Innovations in PD Nurse Education CareMAP: Managing Advanced Parkinson's ...

  6. Parkinson's Disease Videos

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    Full Text Available ... Donna’s Story Aware in Care: Real Stories Is Depression Under-Diagnosed in Patients with Parkinson's Disease? What Are the Neuroprotective Benefits of Exercise for PD Patients? Are There Any Ways to ...

  7. Parkinson's Disease Videos

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    Full Text Available ... Sexuality and Intimacy in Parkinson's Expert Briefings: Improving Communication in Parkinson's Disease: One Voice, Many Listeners Expert ... Too Afraid to Ask Expert Briefings: What's Missing? Communication and the PD Partnership Expert Briefings: Fatigue, Sleep ...

  8. Pathogenesis of Parkinson's disease

    OpenAIRE

    Riederer, Peter; Lange, Klaus W.

    1992-01-01

    The importance of genetic aspects, ageing, environmental factors, head trauma, defective mitochondrial respiration, altered iron metabolism, oxidative stress and glutamatergic overactivity of the basal ganglia in the pathogenesis of Parkinson's disease (PD) are considered in this review.

  9. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... the DBS Device Work? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ... Couric What Are Some Strategies to Improve the Quality of Community Care for PD Patients? CareMAP: Bathroom: ...

  10. Parkinson's Disease Videos

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    Full Text Available ... What Does a Caregiver Need to Know About Cognitive Impairment? What Treatments Exist for Parkinson's Disease Patients ... Medications and General Health Part 1 What Is the Impact of PD ...

  11. Parkinson's Disease Videos

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    Full Text Available ... Challenge: A Panel Discussion OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ... Couric What Are Some Strategies to Improve the Quality of Community Care for PD Patients? CareMAP: Bathroom: ...

  12. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... A You are here Home PD Library Search library Topic Type Nursing Solutions: Improving Caregiver Strain through Science and Model Interventions Expert Briefings: Parkinson's Disease Psychosis: ...

  13. Parkinson's Disease Videos

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    Full Text Available ... Las Actividades en Casa OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis Jose Maria Lobo: Música ... presentadores What Are Some Strategies to Improve the Quality of Community Care for PD Patients? CareMAP: Bathroom: ...

  14. Parkinson's Disease Videos

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    Full Text Available ... the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert Briefings: Parkinson's Disease: Financial, Legal ... Briefings: Complementary Approaches to Parkinson's Expert Briefings: Understanding Pain in Parkinson's Expert Briefings: The Parkinson's Pipeline 2011: ...

  15. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's Pipeline? Expert Briefings: Nutrition and Parkinson's Disease ... our Helpline: 1-800-4PD-INFO (473-4636) © 2018 Parkinson's Foundation Miami: 200 SE 1st Street, Suite ...

  16. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Sexuality and Intimacy in Parkinson's Expert Briefings: Improving Communication in Parkinson's Disease: One Voice, Many Listeners Expert ... You Need to Know Expert Briefings: What's Missing? Communication and the PD Partnership Expert Briefings: Fatigue, Sleep ...

  17. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Day? How Does Parkinson's Disease Affect the Urinary System? 2013 PSA Featuring Katie Couric What Are Some Strategies to Improve the Quality of Community Care for PD Patients? CareMAP: Bathroom: ...

  18. Parkinson's Disease Videos

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    Full Text Available ... Gene and Cell Therapies Expert Briefings: Dealing with Dementia in PD Expert Briefings: Anxiety in Parkinson's Disease ... Day What Is Patient-Centered Care? Dealing with Dementia CareMAP: Life Beyond This Life What Are Some ...

  19. Parkinson's Disease Videos

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    Full Text Available ... Gene and Cell Therapies Expert Briefings: Dealing with Dementia in PD Expert Briefings: Anxiety in Parkinson's Disease ... 1 What Is Patient-Centered Care? Dealing with Dementia CareMAP: Life Beyond This Life What Are Some ...

  20. Parkinson's Disease Videos

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    Full Text Available ... Fundraiser Advocate With Us Local Resources Find an Event My PD Story Volunteer Get Involved What are ... How Is It Treated? OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis What Are Some Strategies ...

  1. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Gene and Cell Therapies Expert Briefings: Dealing with Dementia in PD Expert Briefings: Anxiety in Parkinson's Disease ... See: Dealing With Non-Motor Symptoms Dealing with Dementia CareMAP: Life Beyond This Life Ask the Helpline: ...

  2. Independent Validation of the SEND-PD and Correlation with the MDS-UPDRS Part IA

    Directory of Open Access Journals (Sweden)

    Mayela Rodríguez-Violante

    2014-01-01

    Full Text Available Introduction. Neuropsychiatric symptoms in Parkinson’s disease can be assessed by the MDS-UPDRS part IA. The Scale for Evaluation of Neuropsychiatric Disorders in Parkinson’s disease (SEND-PD has been recently developed to assess the severity of some neuropsychiatric symptoms. The objective of this study is to compare the performance of the SEND-PD with the corresponding items of the MDS-UPDRS part IA. Methods. Patients with Parkinson’s disease were evaluated using the MDS-UPDRS and the SEND-PD by independent raters. Partial SEND-PD and neuropsychiatric MDS-UPDRS part IA were constructed with equivalent items for comparison. Results. A total of 260 consecutive patients were included. Overall, 61.2% of the patients did not report any psychotic symptom and 83.5% did not report any ICD symptom. On the other hand, 78.5% of the patients did report at least one symptom related to apathy, depression, or anxiety. The partial SEND-PD score was 2.9±3.1 (range from 0 to 16. The neuropsychiatric MDS-UPDRS part IA score was 2.9±3 (range from 0 to 14. The correlation coefficient between corresponding items ranged from 0.67 to 0.98 and between both summary indexes was rs=0.93 (all, P<0.001. Conclusion. A high association between equivalent items of the SEND-PD and the MDS-UPDRS was found.

  3. Impact of multiple glacial surges - a geomorphological map from Brúarjökull, East Iceland

    DEFF Research Database (Denmark)

    Kjær, Kurt H.; Korsgaard, Niels Jákup; Schomacker, Anders

    2008-01-01

    Simultaneously with geological field investigations at the surge-type glacier Bruarjokull in August 2003, aerial photographs covering the central part of the glacier including the Kringilsarrani area were recorded with the purpose of mapping glacial landforms. A glacial geomorphological map has...

  4. Hydrodynamic forces and ship motions induced by surges in a navigation lock

    NARCIS (Netherlands)

    Kalkwijk, J.P.T.

    1973-01-01

    This thesis treats the fluid and ship motion in a navigation lock and their mutual interaction as caused by surges, which occur in the chamber during filling or emptying. The other phenomena, which possibly play a role during these processes are ignored. The considerations of this treatise hold good

  5. Surge of Hispar Glacier, Pakistan, between 2013 and 2017 detected from remote sensing observations

    Science.gov (United States)

    Rashid, Irfan; Abdullah, Tariq; Glasser, Neil F.; Naz, Heena; Romshoo, Shakil Ahmad

    2018-02-01

    This study analyses the behaviour of an actively surging glacier, Hispar, in Pakistan using remote sensing methods. We used 15 m panchromatic band of Landsat 8 OLI from 2013 to 2017 to assess the changes in glacier velocity, glacier geomorphology and supraglacial water bodies. For the velocity estimation, correlation image analysis (CIAS) was used, which is based on normalized cross-correlation (NCC) of satellite data. On-screen digitization was employed to quantify changes in the glacier geomorphology and dynamics of supraglacial water bodies on the glacier. Our velocity estimates indicate that the upper part of the glacier is presently undergoing an active surge which not only affects the debris distribution but also impacts the development of supraglacial water bodies. Velocities in the actively surging part of the main glacier trunk and its three tributaries reach up to 900 m yr- 1. The surge of Hispar also impacts the distribution of supraglacial debris causing folding of the medial moraines features present on the glacier surface. Changes in the number and size of supraglacial lakes and ponds were also observed during the observation period from 2013 to 2017.

  6. Predicting the Storm Surge Threat of Hurricane Sandy with the National Weather Service SLOSH Model

    Directory of Open Access Journals (Sweden)

    Cristina Forbes

    2014-05-01

    Full Text Available Numerical simulations of the storm tide that flooded the US Atlantic coastline during Hurricane Sandy (2012 are carried out using the National Weather Service (NWS Sea Lakes and Overland Surges from Hurricanes (SLOSH storm surge prediction model to quantify its ability to replicate the height, timing, evolution and extent of the water that was driven ashore by this large, destructive storm. Recent upgrades to the numerical model, including the incorporation of astronomical tides, are described and simulations with and without these upgrades are contrasted to assess their contributions to the increase in forecast accuracy. It is shown, through comprehensive verifications of SLOSH simulation results against peak water surface elevations measured at the National Oceanic and Atmospheric Administration (NOAA tide gauge stations, by storm surge sensors deployed and hundreds of high water marks collected by the U.S. Geological Survey (USGS, that the SLOSH-simulated water levels at 71% (89% of the data measurement locations have less than 20% (30% relative error. The RMS error between observed and modeled peak water levels is 0.47 m. In addition, the model’s extreme computational efficiency enables it to run large, automated ensembles of predictions in real-time to account for the high variability that can occur in tropical cyclone forecasts, thus furnishing a range of values for the predicted storm surge and inundation threat.

  7. Methodology for the assessment of possible damages in low voltage equipment due to lightning surges

    Energy Technology Data Exchange (ETDEWEB)

    Matsuo, Nelson M.; Kagan, Nelson [University of Sao Paulo (USP), SP (Brazil)], Emails: matsuonm@usp.br, nelsonk@pea.usp.br; Domingues, Ivo T. [AES Eletropaulo, SP (Brazil); Jesus, Nelson C. de [AES Sul, Porto Alegre, RS (Brazil); Silva, Marcelo H.I. da [Grupo Rede, Sao Paulo, SP (Brazil); Takauti, Edson H. [Bandeirante, Sao Paulo, SP (Brazil)

    2007-07-01

    This paper deals with the development of a methodology to assess the possibility of equipment damages in low voltage customers due to lightning surges. The main objective is to incorporate this methodology in a computation system that supports distribution companies to determine the possible causes of equipment damages claimed by customers and to decide whether the claims are to be reimbursed or not. The proposed methodology determines whether a specific customer could be affected by a lightning strike according to his/her location and to the lightning main parameters, by using data from a lightning detection system and from the specific equipment surge withstand capability. A specific study using ATP (Alternative Transients Program) was carried out to assess the propagation of lightning surges in electric power distribution systems and their impact over low voltage customers. On the other hand, the withstand capability of the main household appliances was determined by a series of tests carried out in the University's power quality laboratory. The paper details the modeling used for simulation, such as network configuration, grounding points, and modelling of insulator flashover, distribution transformer, low voltage loads. It also presents some results regarding the evaluation of over voltages in low voltage customers installations. A practical method is proposed for assessing the possibility of equipment damage and describes how the existing uncertainties were handled. Also, some issues regarding the withstand capability of electric household appliances to lightning surges are discussed and some results of the laboratory tests are presented. (author)

  8. Idealised modelling of storm surges in large-scale coastal basins

    NARCIS (Netherlands)

    Chen, Wenlong

    2015-01-01

    Coastal areas around the world are frequently attacked by various types of storms, threatening human life and property. This study aims to understand storm surge processes in large-scale coastal basins, particularly focusing on the influences of geometry, topography and storm characteristics on the

  9. Improving short-range ensemble Kalman storm surge forecasting using robust adaptive inflation

    NARCIS (Netherlands)

    Altaf, M.U.; Butler, T.; Luo, X.; Dawson, C.; Mayo, T.; Hoteit, I.

    2013-01-01

    This paper presents a robust ensemble filtering methodology for storm surge forecasting based on the singular evolutive interpolated Kalman (SEIK) filter, which has been implemented in the framework of the H? filter. By design, an H? filter is more robust than the common Kalman filter in the sense

  10. Impact of hydrogeological factors on groundwater salinization due to ocean-surge inundation

    Science.gov (United States)

    Yang, Jie; Zhang, Huichen; Yu, Xuan; Graf, Thomas; Michael, Holly A.

    2018-01-01

    Ocean surges cause seawater inundation of coastal inland areas. Subsequently, seawater infiltrates into coastal aquifers and threatens the fresh groundwater resource. The severity of resulting salinization can be affected by hydrogeological factors including aquifer properties and hydrologic conditions, however, little research has been done to assess these effects. To understand the impacts of hydrogeological factors on groundwater salinization, we numerically simulated an ocean-surge inundation event on a two-dimensional conceptual coastal aquifer using a coupled surface-subsurface approach. We varied model permeability (including anisotropy), inland hydraulic gradient, and recharge rate. Three salinization-assessment indicators were developed, based on flushing time, depth of salt penetration, and a combination of the two, weighted flushing time, with which the impact of hydrogeological factors on groundwater vulnerability to salinization were quantitatively assessed. The vulnerability of coastal aquifers increases with increasing isotropic permeability. Low horizontal permeability (kx) and high vertical permeability (kz) lead to high aquifer vulnerability, and high kx and low kz lead to low aquifer vulnerability. Vulnerability decreases with increasing groundwater hydraulic gradient and increasing recharge rate. Additionally, coastal aquifers with a low recharge rate (R ≤ 300 mm yr-1) may be highly vulnerable to ocean-surge inundation. This study shows how the newly introduced indicators can be used to quantitatively assess coastal aquifer vulnerability. The results are important for global vulnerability assessment of coastal aquifers to ocean-surge inundation.

  11. An Idealized Meteorological-Hydrodynamic Model for Exploring Extreme Storm Surge Statistics in the North Sea

    NARCIS (Netherlands)

    Van Ledden, M.; Van den Berg, N.J.F.; De Jong, M.S.; Van Gelder, P.H.A.J.M.; Den Heijer, C.; Vrijling, J.K.; Jonkman, S.N.; Roos, P.C.; Hulscher, S.J.M.H.; Lansen, A.J.

    2014-01-01

    This paper explores an alternative method to determine extreme surge levels at the Dutch Coast. For this exploration, specific focus is on the extreme water level at Hoek van Holland, The Netherlands. The alternative method has been based on a joint probability model of the storm characteristics at

  12. Prognostic value of the morning blood pressure surge in 5645 subjects from 8 populations

    DEFF Research Database (Denmark)

    Li, Yan; Thijs, Lutgarde; Hansen, Tine W

    2010-01-01

    Previous studies on the prognostic significance of the morning blood pressure surge (MS) produced inconsistent results. Using the International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcome, we analyzed 5645 subjects (mean age: 53.0 years; 54.0% women) randomly recru...

  13. ISSN 2073 ISSN 2073-9990 East Cent. Afr. J. surg. (Online) 9990 ...

    African Journals Online (AJOL)

    Prof Kakande

    Afr. J. surg. (Online). COSECSA/ASEA Publication. COSECSA/ASEA Publication -East and Central African Journal of Surgery. East and Central African Journal of Surgery. East and Central African Journal of Surgery. July/August 2012 Volume 17 (2). July/August 2012 Volume 17 (2) treatment from local drug shops, clinics ...

  14. Control of the Estradiol-Induced Prolactin Surge by the Suprachiasmatic Nucleus

    NARCIS (Netherlands)

    Palm, Inge F.; van der Beek, Eline M.; Swarts, Hans J. M.; van der Vliet, Jan; Wiegant, Victor M.; Buijs, Ruud M.; Kalsbeek, Andries

    2001-01-01

    In the present study we investigated how the suprachiasmatic nucleus (SCN) controls the E(2)-induced PRL surge in female rats. First, the role of vasopressin (VP), a SCN transmitter present in medial preoptic area (MPO) projections and rhythmically released by SCN neurons, as a circadian signal for

  15. East China Sea Storm Surge Modeling and Visualization System: The Typhoon Soulik Case

    Directory of Open Access Journals (Sweden)

    Zengan Deng

    2014-01-01

    Full Text Available East China Sea (ECS Storm Surge Modeling System (ESSMS is developed based on Regional Ocean Modeling System (ROMS. Case simulation is performed on the Typhoon Soulik, which landed on the coastal region of Fujian Province, China, at 6 pm of July 13, 2013. Modeling results show that the maximum tide level happened at 6 pm, which was also the landing time of Soulik. This accordance may lead to significant storm surge and water level rise in the coastal region. The water level variation induced by high winds of Soulik ranges from −0.1 to 0.15 m. Water level generally increases near the landing place, in particular on the left hand side of the typhoon track. It is calculated that 0.15 m water level rise in this region can cause a submerge increase of ~0.2 km2, which could be catastrophic to the coastal environment and the living. Additionally, a Globe Visualization System (GVS is realized on the basis of World Wind to better provide users with the typhoon/storm surge information. The main functions of GVS include data indexing, browsing, analyzing, and visualization. GVS is capable of facilitating the precaution and mitigation of typhoon/storm surge in ESC in combination with ESSMS.

  16. Storm surges in the Singapore Strait due to winds in the South China Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Tkalich, P.; Vethamony, P.; Babu, M.T.; Malanotte-Rizzoli, P.

    on the north, Karimata Strait on the south, east cost of Peninsular Malaysia on the west, and break of Sunda Shelf on the east, could experience positive or negative SLAs depending on the wind direction and speed. Strong sea level surges during NE monsoon...

  17. Exploring Water Level Sensitivity for Metropolitan New York during Sandy (2012 Using Ensemble Storm Surge Simulations

    Directory of Open Access Journals (Sweden)

    Brian A. Colle

    2015-06-01

    Full Text Available This paper describes storm surge simulations made for Sandy (2012 for the Metropolitan New York (NYC area using the Advanced Circulation (ADCIRC model forced by the Weather Research and Forecasting (WRF model. The atmospheric forecast uncertainty was quantified using 11-members from an atmospheric Ensemble Kalman Filter (EnKF system. A control WRF member re-initialized every 24 h demonstrated the capability of the WRF-ADCIRC models to realistically simulate the 2.83 m surge and 4.40 m storm tide (surge + astronomical tide above mean lower low water (MLLW for NYC. Starting about four days before landfall, an ensemble of model runs based on the 11 “best” meteorological predictions illustrate how modest changes in the track (20–100 km and winds (3–5 m s−1 of Sandy approaching the New Jersey coast and NYC can lead to relatively large (0.50–1.50 m storm surge variations. The ensemble also illustrates the extreme importance of the timing of landfall relative to local high tide. The observed coastal flooding was not the worst case for this particular event. Had Sandy made landfall at differing times, locations and stages of the tide, peak water levels could have been up to 0.5 m higher than experienced.

  18. Hindcast and validation of Hurricane Ike waves, forerunner, and storm surge

    NARCIS (Netherlands)

    Hope, M.E.; Westerink, J.J.; Kennedy, A.B.; Kerr, P.C.; Dietrich, J.C.; Dawson, C.; Bender, C.J.; Smith, J.M.; Jensen, R.E.; Zijlema, M.; Holthuijsen, L.H.; Luettich, R.A.; Powell, M.D.; Cardone, V.J.; Cox, A.T.; Pourtaheri, H.; Roberts, H.J.; Atkinson, J.H.; Tanaka, S.; Westerink, H.J.; Westerink, L.G.

    2013-01-01

    Hurricane Ike (2008) made landfall near Galveston, Texas, as a moderate intensity storm. Its large wind field in conjunction with the Louisiana-Texas coastline's broad shelf and large scale concave geometry generated waves and surge that impacted over 1000 km of coastline. Ike's complex and varied

  19. On the effect of pulsating flow on surge margin of small centrifugal compressors for automotive engines

    Energy Technology Data Exchange (ETDEWEB)

    Galindo, J.; Climent, H.; Guardiola, C.; Tiseira, A. [CMT-Motores Termicos, Universidad Politecnica de Valencia (Spain); Camino de Vera s/n, E 46022, Valencia (Spain)

    2009-11-15

    Surge is becoming a limiting factor in the design of boosting systems of downsized diesel engines. Although standard compressor flowcharts are used for the selection of those machines for a given application, on-engine conditions widely differ from steady flow conditions, thus affecting compressor behaviour and consequently surge phenomenon. In this paper the effect of pulsating flow is investigated by means of a steady gas-stand that has been modified to produce engine-like pulsating flow. The effect of pressure pulses' amplitude and frequency on the compressor surge line location has been checked. Results show that pulsating flow in the 40-67 Hz range (corresponding to characteristic pulsation when boosting an internal combustion engine) increases surge margin. This increased margin is similar for all the tested frequencies but depends on pulsation amplitude. In a further step, a non-steady compressor model is used for modelling the tests, thus allowing a deeper analysis of the involved phenomena. Model results widely agree with experimental results. (author)

  20. Electroconvulsive therapy, hypertensive surge, blood-brain barrier breach, and amnesia

    DEFF Research Database (Denmark)

    Andrade, Chittaranjan; Bolwig, Tom G

    2014-01-01

    Preclinical and clinical evidence show that electroconvulsive therapy (ECT)-induced intraictal surge in blood pressure may result in a small, transient breach in the blood-brain barrier, leading to mild cerebral edema and a possible leach of noxious substances from blood into brain tissues. These...

  1. The Major Cause of Observed Erosion Surge on the Beaches North ...

    African Journals Online (AJOL)

    Surges in coastal erosion north of Dar es Salaam city have been documented from 1977 to the early 1980s and around 1997/98. Analysis of the wind data shows that the documented increase in coastal erosion coincided with increased wind speeds. Extreme winds in excess of 10-11 m s-1 were experienced during ...

  2. An Investigation of Surge in a High-Speed Centrifugal Compressor Using Digital PIV

    Science.gov (United States)

    Wernet, Mark P.; Bright, Michelle M.; Skoch, Gary J.

    2002-01-01

    Compressor stall is a catastrophic breakdown of the flow in a compressor, which can lead to a loss of engine power, large pressure transients in the inlet/nacelle and engine flameout. The implementation of active or passive strategies for controlling rotating stall and surge can significantly extend the stable operating range of a compressor without substantially sacrificing performance. It is crucial to identify the dynamic changes occurring in the flow field prior to rotating stall and surge in order to successfully control these events. Generally, pressure transducer measurements are made to capture the transient response of a compressor prior to rotating stall. In this investigation, Digital Particle Imaging Velocimetry (DPIV) is used in conjunction with dynamic pressure transducers to simultaneously capture transient velocity and pressure measurements in the non-stationary flow field during compressor surge. DPIV is an instantaneous, planar measurement technique which is ideally suited for studying transient flow phenomena in high speed turbomachinery and has been used previously to successfully map the stable operating point flow field in the diffuser of a high speed centrifugal compressor. Through the acquisition of both DPIV images and transient pressure data, the time evolution of the unsteady flow during surge is revealed.

  3. Visual Symptoms in Parkinson's Disease

    OpenAIRE

    R. A. Armstrong

    2011-01-01

    Parkinson’s disease (PD) is a common disorder of middle-aged and elderly people in which degeneration of the extrapyramidal motor system causes significant movement problems. In some patients, however, there are additional disturbances in sensory systems including loss of the sense of smell and auditory and/or visual problems. This article is a general overview of the visual problems likely to be encountered in PD. Changes in vision in PD may result from alterations in visual acuity, contrast...

  4. Apathy in Parkinson's disease patients

    OpenAIRE

    M. R. Nodel

    2014-01-01

    pathy in Parkinson's disease (PD) patients is one of the least studied manifestations of a broad range of neuropsychic disorders. According to numerous researchers, the rate of apathy in PD patients is 17–80%. The structural and neurochemical changes associated with PD have been considered to be the leading pathophysiological factors of apathy. The possible general pathophysiological mechanisms are discussed for apathy and hypokinesia, depression, executive (frontal) cognitive functions, and ...

  5. Apathy dimensions in Parkinson's disease

    OpenAIRE

    Radakovic, Ratko; Davenport, Richard; Starr, John M; Abrahams, Sharon

    2018-01-01

    OBJECTIVE: Apathy is a prominent and disabling symptom in Parkinson's disease (PD) and is a multidimensional behaviour, but which dimensions are specifically affected is unclear. Therefore, the aim of this preliminary study was to determine the psychometric properties of the Dimensional Apathy Scale (DAS) and explore the multidimensional profile of apathy in PD patients. METHODS: Thirty-four PD patients, with 30 of their informants/carers, and 34 healthy controls, with 30 of their informants,...

  6. Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner

    Directory of Open Access Journals (Sweden)

    Christodoulos Filippis

    2017-12-01

    Full Text Available Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1 have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L interaction negatively regulates T-cell effector functions, which are required for parasite control during leishmaniasis. The aim of this study was to elucidate the impact of the PD-1/PD-L axis in a human primary in vitro infection model of Leishmania major (Lm. Blocking the PD-1/PD-L interaction with nivolumab increased T-cell proliferation and release of the proinflammatory cytokines TNFα and IFNγ during the cocultivation of Lm-infected human monocyte-derived macrophages (hMDMs or dendritic cells (hMDDC with autologous PD-1+-lymphocytes. As a consequence Lm infection decreased, being the most pronounced in hMDDC, compared to proinflammatory hMDM1 and anti-inflammatory hMDM2. Focusing on hMDDC, we could partially reverse effects mediated by PD-1 blockade by neutralizing TNFα but not by neutralizing IFNγ. Furthermore, PD-1 blockade increased intracellular expression of perforin, granulysin, and granzymes in proliferating CD4+-T-cells, which might be implicated in reduction of Lm-infected cells. In all, our data describe an important role for the PD-1/PD-L axis upon Lm infection using a human primary cell system. These data contribute to a better understanding of the PD-1-induced T-cell impairment during disease and its influence on immune effector mechanisms to combat Lm infection.

  7. Simulating storm surge inundation and damage potential within complex port facilities

    Science.gov (United States)

    Mawdsley, Robert; French, Jon; Fujiyama, Taku; Achutan, Kamalasudhan

    2017-04-01

    Storm surge inundation of port facilities can cause damage to critical elements of infrastructure, significantly disrupt port operations and cause downstream impacts on vital supply chains. A tidal surge in December 2013 in the North Sea partly flooded the Port of Immingham, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. This flooding caused damage to port and rail transport infrastructure and disrupted operations for several weeks. This research aims to improve resilience to storm surges using hydrodynamic modelling coupled to an agent-based model of port operations. Using the December 2013 event to validate flood extent, depth and duration, we ran a high resolution hydrodynamic simulation using the open source Telemac 2D finite element code. The underlying Digital Elevation Model (DEM) was derived from Environment Agency LiDAR data, with ground truthing of the flood defences along the port frontage. Major infrastructure and buildings are explicitly resolved with varying degrees of permeability. Telemac2D simulations are run in parallel and take only minutes on a single 16 cpu compute node. Inundation characteristics predicted using Telemac 2D differ from a simple Geographical Information System 'bath-tub' analysis of the DEM based upon horizontal application of the maximum water level across the port topography. The hydrodynamic simulation predicts less extensive flooding and more closely matches observed flood extent. It also provides more precise depth and duration curves. Detailed spatial flood depth and duration maps were generated for a range of tide and surge scenarios coupled to mean sea-level rise projections. These inundation scenarios can then be integrated with critical asset databases and an agent-based model of port operation (MARS) that is capable of simulating storm surge disruption along wider supply chains. Port operators are able to act on information from a particular

  8. Development of Storm Surge Hazard Maps and Advisory System for the Philippines

    Science.gov (United States)

    Santiago, Joy; Mahar Francisco Lagymay, Alfredo; Caro, Carl Vincent; Suarez, John Kenneth; Tablazon, Judd; Dasallas, Lea; Garnet Goting, Prince

    2016-04-01

    The Philippines, located in the most active region of cyclogenesis in the world, experiences an average of 20 tropical cyclones annually. Strong winds brought by tropical cyclones, among other factors, cause storm surges that inundate the coastal areas of the country. As an archipelago with the fourth longest coastline in the world, the country is expose to the threats of storm surges. This was manifested by Typhoon Haiyan on 8 November 2013, which devastated the country and left 6,293 deaths and approximately USD 2 billion worth of damages. To prevent such disaster from happening again, the Nationwide Operational Assessment of Hazards (Project NOAH) developed a Storm Surge Advisory (SSA) that aims to warn communities in coastal areas against impending floods due to storm surges. The Japan Meteorological Agency storm surge model was used to simulate 721 tropical cyclones that entered the Philippine Area of Responsibility from 1951-2013. The resulting storm surge time series from the simulations were added to the maximum tide levels from the WXTide software for the 4,996 observation points placed nearshore in the entire country. The storm tide levels were categorized into four groups based on their peak height to create the SSA - SSA 1 (0.01m to 2m), SSA 2 (2.01m to 3m), SSA 3 (3.01m to 4m), and SSA 4 (4m and above). The time series for each advisory level was used in inundation modelling using FLO-2D, a two-dimensional flood modeling software that uses continuity and dynamic wave momentum equation. The model produced probable extent, depth of inundation, and hazard level for each advisory level. The SSA hazard maps are used as reference to warn communities that are likely to be affected by storm surges. Advisory is released 24 hours in advance and is updated every six hours in the Project NOAH website. It is also being utilized in the pre-disaster risk assessment of the national government agencies and local government units in designing appropriate response to

  9. Effect of Reverse Triage on Creation of Surge Capacity in a Pediatric Hospital.

    Science.gov (United States)

    Kelen, Gabor D; Troncoso, Ruben; Trebach, Joshua; Levin, Scott; Cole, Gai; Delaney, Caitlin M; Jenkins, J Lee; Fackler, James; Sauer, Lauren

    2017-04-03

    The capacity of pediatric hospitals to provide treatment to large numbers of patients during a large-scale disaster remains a concern. Hospitals are expected to function independently for as long as 96 hours. Reverse triage (early discharge), a strategy that creates surge bed capacity while conserving resources, has been modeled for adults but not pediatric patients. To estimate the potential of reverse triage for surge capacity in an academic pediatric hospital. In this retrospective cohort study, a blocked, randomized sampling scheme was used including inpatients from 7 units during 196 mock disaster days distributed across the 1-year period from December 21, 2012, through December 20, 2013. Patients not requiring any critical interventions for 4 successive days were considered to be suitable for low-risk immediate reverse triage. Data were analyzed from November 1, 2014, through November 21, 2016. Proportionate contribution of reverse triage to the creation of surge capacity measured as a percentage of beds newly available in each unit and in aggregate. Of 3996 inpatients, 501 were sampled (268 boys [53.5%] and 233 girls [46.5%]; mean [SD] age, 7.8 [6.6] years), with 10.8% eligible for immediate low-risk reverse triage and 13.2% for discharge by 96 hours. The psychiatry unit had the most patients eligible for immediate reverse triage (72.7%; 95% CI, 59.6%-85.9%), accounting for more than half of the reverse triage effect. The oncology (1.3%; 95% CI, 0.0%-3.9%) and pediatric intensive care (0%) units had the least effect. Gross surge capacity using all strategies (routine patient discharges, full use of staffed and unstaffed licensed beds, and cancellation of elective and transfer admissions) was estimated at 57.7% (95% CI, 38.2%-80.2%) within 24 hours and 84.1% (95% CI, 63.9%-100%) by day 4. Net surge capacity, estimated by adjusting for routine emergency department admissions, was about 50% (range, 49.1%-52.6%) throughout the 96-hour period. By accepting higher

  10. Parkinson Disease and Dementia.

    Science.gov (United States)

    Garcia-Ptacek, Sara; Kramberger, Milica G

    2016-09-01

    Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present. This review provides an update on current knowledge of PDD including aspects of epidemiology, pathology, clinical presentation, management, and prognosis. © The Author(s) 2016.

  11. The impact of high intensity physical training on motor and non-motor symptoms in patients with Parkinson's disease (PIP)

    DEFF Research Database (Denmark)

    Morberg, Bo M; Jensen, Joakim; Bode, Matthias

    2014-01-01

    BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic nigrostriatal neurons. Several studies have investigated various physical interventions on PD. The effects of a high intensity exercise program with focus on resistance; cardio; equilibrium; and fle...

  12. Dissociating apathy and depression in Parkinson disease

    Science.gov (United States)

    Kirsch-Darrow, L.; Fernandez, H.F.; Marsiske, M.; Okun, M.S.; Bowers, D.

    2010-01-01

    Objective To examine the hypothesis that apathy is a core feature of Parkinson disease (PD) and that apathy can be dissociated from depression. Methods Eighty patients with PD and 20 patients with dystonia completed depression and apathy measures including the Marin Apathy Evaluation Scale (AES), Beck Depression Inventory (BDI), and Centers for Epidemiologic Studies–Depression Scale (CES-D). Results There was a significantly higher severity and frequency of apathy in PD (frequency = 51%, 41/80) than in dystonia (frequency = 20%, 4/20). Apathy in the absence of depression was frequent in PD and did not occur in dystonia (PD = 28.8%, dystonia = 0%). Conclusions Patients with Parkinson disease (PD) experienced significantly higher frequency and severity of apathy when compared with patients with dystonia. Apathy may be a “core” feature of PD and occurs in the absence of depression. PMID:16832074

  13. New Dancing Couple: PD-L1 and MicroRNA.

    Science.gov (United States)

    Grenda, A; Krawczyk, P

    2017-09-01

    Lung cancer (LC) is the most common cause of cancer death in the world. A great challenge in treating NSCLC is the discovery of advanced, molecular tools to diagnose the disease in early stages as well as the development of immunotherapy. MicroRNAs are regulatory molecules (~20 nt in length) with the ability to regulate the expression of genes. The recently described PD-1 and PD-L1 molecules have great importance for potential use in immunotherapy of many cancers. These molecules are associated with immune checkpoints and provide an opportunity for the treatment of advanced NSCLC patients with synthetic monoclonal antibodies. PD-L1 expression is strictly associated with microRNA function in lung cancer cells. The group of microRNAs related to PD-L1 includes, among others, miR-200, miR-197 or miRNA-34. Expression of these molecules may be useful in lung cancer diagnosis, qualification to anti-PD-1 or anti-PD-L1 antibody therapy and could be a potential therapeutic target. However, studies on PD-L1-related microRNAs are necessary to develop advanced targeted molecular therapies. © 2017 The Foundation for the Scandinavian Journal of Immunology.

  14. Psychogenic and neural visual-cue response in PD dopamine dysregulation syndrome.

    Science.gov (United States)

    Loane, Clare; Wu, Kit; O'Sullivan, Sean S; Lawrence, Andrew D; Woodhead, Zoe; Lees, Andrew J; Piccini, Paola; Politis, Marios

    2015-11-01

    Dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) patients refers to the compulsive use of dopaminergic replacement therapy and has serious psycho-social consequences. Mechanisms underlying DDS are not clear although has been linked to dysfunctional brain reward networks. With fMRI, we investigate behavioral and neural response to drug-cues in six PD DDS patients and 12 PD control patients in both the ON and OFF medication state. Behavioral measures of liking, wanting and subjectively 'feeling ON medication' were also collected. Behaviorally, PD DDS patients feel less ON and want their drugs more at baseline compared to PD controls. Following drug-cue exposure, PD DDS patients feel significantly more ON medication, which correlates with significant increases in reward related regions. The results demonstrate that exposure to drug-cues increases the subjective feeling of being 'ON' medication which corresponds to dysfunctional activation in reward related regions in PD DDS patients. These findings should be extended in future studies. Visual stimuli being sufficient to elicit behavioral response through neuroadaptations could have direct implications to the management of addictive behavior. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition

    Directory of Open Access Journals (Sweden)

    Jonathan W. Nyce

    2017-01-01

    Full Text Available Glucose-6-phosphate dehydrogenase (G6PD is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism. NADPH, sourced from G6PD fuels nucleotide biosynthesis, maintains redox potential of thioredoxin and glutathione and drives the mevalonate pathway that powers many of the basic mechanisms by which cancer cells escape host control. G6PD is thus a target for cancer treatment being addressed by many groups around the world. We have discovered that systemic inhibition of G6PD by high dose dehydroepiandrosterone (DHEA causes a severe autoinflammatory response in dogs, which does not occur in mice or rats. Since dogs more closely model the human adrenal androgen system than do common laboratory animals, this finding is relevant to the design of G6PD-inhibiting drugs for humans. The autoinflammatory reaction observed closely resembles mevalonate kinase deficiency (MKD, a rare autosomal recessive disease in humans characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous tissues. In a manner comparable to animal models of MKD, the reconstitution of protein geranylgeranylation blocked the autoinflammatory reaction caused by systemic G6PD inhibition. This autoinflammatory response to systemic G6PD inhibition represents an unexpected result that must be taken into consideration when targeting this oncoprotein.

  16. PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma.

    Science.gov (United States)

    Nayak, Lakshmi; Iwamoto, Fabio M; LaCasce, Ann; Mukundan, Srinivasan; Roemer, Margaretha G M; Chapuy, Bjoern; Armand, Philippe; Rodig, Scott J; Shipp, Margaret A

    2017-06-08

    Primary central nervous system (CNS) lymphoma (PCNSL) and primary testicular lymphoma (PTL) are rare extranodal large B-cell lymphomas with similar genetic signatures. There are no standard-of-care treatment options for patients with relapsed and refractory PCNSL and PTL, and the overall prognosis is poor. PCNSLs and PTLs exhibit frequent 9p24.1 copy-number alterations and infrequent translocations of 9p24.1 and associated increased expression of the programmed cell death protein 1 (PD-1) ligands, PD-L1 and PD-L2. The activity of PD-1 blockade in other lymphomas with 9p24.1 alterations prompted us to test the efficacy of the anti-PD1 antibody, nivolumab, in 4 patients with relapsed/refractory PCNSL and 1 patient with CNS relapse of PTL. All 5 patients had clinical and radiographic responses to PD-1 blockade, and 3 patients remain progression-free at 13 + to 17 + months. Our data suggest that nivolumab is active in relapsed/refractory PCNSL and PTL and support further investigation of PD-1 blockade in these diseases. © 2017 by The American Society of Hematology.

  17. Morning surge in blood pressure using a random-effects multiple-component cosinor model.

    Science.gov (United States)

    Madden, J M; Browne, L D; Li, X; Kearney, P M; Fitzgerald, A P

    2018-01-29

    Blood pressure (BP) fluctuates throughout the day. The pattern it follows represents one of the most important circadian rhythms in the human body. For example, morning BP surge has been suggested as a potential risk factor for cardiovascular events occurring in the morning, but the accurate quantification of this phenomenon remains a challenge. Here, we outline a novel method to quantify morning surge. We demonstrate how the most commonly used method to model 24-hour BP, the single cosinor approach, can be extended to a multiple-component cosinor random-effects model. We outline how this model can be used to obtain a measure of morning BP surge by obtaining derivatives of the model fit. The model is compared with a functional principal component analysis that determines the main components of variability in the data. Data from the Mitchelstown Study, a population-based study of Irish adults (n = 2047), were used where a subsample (1207) underwent 24-hour ambulatory blood pressure monitoring. We demonstrate that our 2-component model provided a significant improvement in fit compared with a single model and a similar fit to a more complex model captured by b-splines using functional principal component analysis. The estimate of the average maximum slope was 2.857 mmHg/30 min (bootstrap estimates; 95% CI: 2.855-2.858 mmHg/30 min). Simulation results allowed us to quantify the between-individual SD in maximum slopes, which was 1.02 mmHg/30 min. By obtaining derivatives we have demonstrated a novel approach to quantify morning BP surge and its variation between individuals. This is the first demonstration of cosinor approach to obtain a measure of morning surge. Copyright © 2018 John Wiley & Sons, Ltd.

  18. PIV investigation of the flow induced by a passive surge control method in a radial compressor

    Science.gov (United States)

    Guillou, Erwann; Gancedo, Matthieu; Gutmark, Ephraim; Mohamed, Ashraf

    2012-09-01

    Due to recent emission regulations, the use of turbochargers for force induction of internal combustion engines has increased. Actually, the trend in diesel engines is to downsize the engine by use of turbochargers that operate at higher pressure ratios. Unfortunately, increasing the impeller rotational speed of turbocharger radial compressors tends to reduce their range of operation, which is limited at low mass flow rate by the occurrence of surge. In order to extend the operability of turbochargers, compressor housings can be equipped with a passive surge control device such as a "ported shroud." This specific casing treatment has been demonstrated to enhance the surge margin with minor negative impact on the compressor efficiency. However, the actual working mechanisms of the system remain not well understood. Hence, in order to optimize the design of the ported shroud, it is crucial to identify the dynamic flow changes induced by the implementation of the device to control instabilities. From the full dynamic survey of the compressor performance characteristics obtained with and without ported shroud, specific points of operation were selected to carry out planar flow visualization. At normal working, both standard and stereoscopic particle imaging velocimetry (PIV) measurements were performed to evaluate instantaneous and mean velocity flow fields at the inlet of the compressor. At incipient and full surge, phase-locked PIV measurements were added. As a result, satisfying characterization of the compressor instabilities was provided at different operational speeds. Combining transient pressure data and PIV measurements, the time evolution of the complex flow patterns occurring at surge was reconstructed and a better insight into the bypass mechanism was achieved.

  19. Sedimentological recorders of the 2013 Typhoon Haiyan storm surge from contrasting Philippine coastal landscapes

    Science.gov (United States)

    Soria, J. L.; Switzer, A.; Siringan, F. P.; Pilarczyk, J.; Li, L.

    2016-12-01

    Typhoon Haiyan in 2013 was an extremely intense and fast moving typhoon. It claimed more than 6000 lives, caused widespread damage, and affected more than 16 million people along its path in central Philippines. Overwash associated with the 5 to 8 m storm surge of Typhoon Haiyan also left behind a variety of geomorphic and sedimentological imprints, which provide a valuable dataset for modern storm deposits in different landform settings. Here we only present a synthesis of the sedimentological imprints from sites that span clastic, mixed clastic-carbonate, and non-clastic carbonate coasts, and were affected by contrasting surge mechanisms. On the sheltered clastic coast where overwash was dominated by wind-induced setup surge, the overwash sediments occur as a sand unit of no more than 20 cm near the shore, and then spread into sub-cm thin sandsheet that blanket pre-Haiyan soil surfaces up to 1.6 km inland. Thicker sections of the overwash sand exhibit sharp depositional contacts, planar stratification, and generally coarsen upward and fine landward. On the mixed clastic-carbonate coast, the Typhoon Haiyan deposits are generally thin (reef flat surface, and a sand sheet that blanketed the coastal plain up to 300 m distance inland. On the open coast, inverse modeling of flow velocities derived from boulder dimensions, sediment thickness, and grain size distributions indicate that the storm surge travelled across the wide reef flat and inundated the coast with flow velocities exceeding 4 ms-1. The sediment data support the tsunami-like surge characteristics of Haiyan, and although Haiyan's overwash sediments are clearly representative of Philippine modern storm deposits, they should however be used with caution in the interpretation of the geologic record. This cautionary note highlights the continuing issue of differentiating storms from tsunamis in many settings and is particularly important for tropical coasts that are similarly exposed to the impacts of both

  20. Rapid assessment tool for tropical cyclone waves and storm surge hazards in Mexico

    Science.gov (United States)

    Appendini, Christian M.; Rosengaus, Michel; Meza-Padilla, Rafael; Camacho-Magaña, Victor

    2017-04-01

    Mexico is under the constant threat of tropical cyclones generated in the Atlantic and the Eastern Pacific oceans. While the National Hurricane Center (NHC) in Miami is responsible for the forecast of tropical cyclones in both basins and providing watch and warning areas information for Mexico, Central America and the Caribbean, they are not responsible to issue waves and storm surge hazards. This work presents a quick assessment tool for waves and storm surge hazards developed under conditions that are common to developing countries: tight budget and time constraints, as well as limited numerical modeling capabilities. The system is based on 3100 synthetic tropical cyclones doing landfall in Mexico. Hydrodynamic and wave models were driven by the synthetic events to create a robust database composed of maximum envelops of wind speed, significant wave height and storm surge for each event. The results were incorporated into a forecast system that uses the NHC advisory to locate the synthetic events passing inside specified radiuses for the present and forecast position of the real event. Using limited computer resources, the system displays the information meeting the search criteria, and the forecaster can select specific events to generate the desired hazard map (i.e. wind, waves, and storm surge) based on the maximum envelop maps. This system was developed in a limited time frame to be operational in 2015 by the Hurricane and Severe Storms Unit of the Mexican National Weather Service, and represents a pilot project for other countries in the region not covered by detailed storm surge and waves forecasts.

  1. Twentieth century surge of excess adult male mortality

    Science.gov (United States)

    Beltrán-Sánchez, Hiram; Finch, Caleb E.; Crimmins, Eileen M.

    2015-01-01

    Using historical data from 1,763 birth cohorts from 1800 to 1935 in 13 developed countries, we show that what is now seen as normal—a large excess of female life expectancy in adulthood—is a demographic phenomenon that emerged among people born in the late 1800s. We show that excess adult male mortality is clearly rooted in specific age groups, 50–70, and that the sex asymmetry emerged in cohorts born after 1880 when male:female mortality ratios increased by as much as 50% from a baseline of about 1.1. Heart disease is the main condition associated with increased excess male mortality for those born after 1900. We further show that smoking-attributable deaths account for about 30% of excess male mortality at ages 50–70 for cohorts born in 1900–1935. However, after accounting for smoking, substantial excess male mortality at ages 50–70 remained, particularly from cardiovascular disease. The greater male vulnerability to cardiovascular conditions emerged with the reduction in infectious mortality and changes in health-related behaviors. PMID:26150507

  2. MYC expression correlates with PD-L1 expression in non-small cell lung cancer.

    Science.gov (United States)

    Kim, Eun Young; Kim, Arum; Kim, Se Kyu; Chang, Yoon Soo

    2017-08-01

    Objectives Programmed death-ligand 1 (PD-L1) is a widely used biomarker for predicting immune checkpoint inhibitors, but is of limited usefulness in the prediction of drug response. MYC, a transcription factor that is overexpressed in cancers, is involved in preventing immune cells from attacking tumor cells through inducing PD-L1 expression. This study evaluated the relationship between MYC and PD-L1 expression in 84 non-small cell lung cancer (NSCLC) patients who underwent curative surgical resection. Materials and Methods The relationship between MYC and PD-L1 was investigated by introducing pcDNA3-cMYC into A549 and H1299 cells with low PD-L1 expression and siRNA against MYC into H60 and H2009 cells with high PD-L1 expression. Expression of PD-L1 in NSCLC tissues was analyzed by immunostaining using a PD-L1 (22C3) PharmDx protocol using the Dako Automated Link 48 platform and expression of MYC was determined using anti-c-MYC (Y69) (ab320720). Results Of 84 patients, PD-L1 was expressed in 14 (16.7%) and MYC was overexpressed in 30 (35.7%). We investigated the relationship between PD-L1 and MYC expression. There were 49 (58.3%) double-negative patients and 9 (10.7%) double-positive patients. Significant positive correlation was observed between PD-L1 and MYC expression (γ=0.210, P=0.029). Double-negative patients showed better disease free (31.1 vs. 7.1 months, P=0.011) and overall survival (56.1 vs. 14.4 months, P=0.032) than double-positive patients. Conclusion Taken together, MYC expression significantly correlated with PD-L1 expression in NSCLC. The usefulness of MYC expression as a surrogate marker of treatment response assessment is worth evaluating for immune checkpoint inhibitor therapy and special interest are required for the subgroup of NSCLC patients, whose tumor expresses PD-L1 and MYC double positive. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Familial Aggregation of Panic Disturbances in Parkinson’s Disease

    OpenAIRE

    Pontone, Gregory M.; Palanci, Justin; Bienvenu, O. Joseph; Liang, Kung-Yee; Nestadt, Gerald; Rabins, Peter V.; Williams, James R.; Marsh, Laura

    2011-01-01

    Panic disorder has an elevated prevalence in Parkinson’s disease (PD). To explore the basis for this co-occurrence, the familial aggregation of panic disorder was examined in patients with PD. Probands and relatives of patients with PD and panic disorder (PD-PANIC; N=20, N=115) and control probands with PD and no active psychiatric illness (PD-NA; N=17, N=108) were interviewed by phone, using a structured interview to determine panic status. Lifetime prevalence of panic and “panic-like” disor...

  4. Surge Capacity and Capability. A review of the history and where the science is today regarding surge capacity during a mass casualty disaster.

    Directory of Open Access Journals (Sweden)

    Randy D. Kearns

    2014-04-01

    Full Text Available Disasters which include countless killed and many more injured, have occurred throughout recorded history. Many of the same reports of disaster also include numerous accounts of individuals attempting to rescue those in great peril and render aid to the injured and infirmed. The purpose of this paper is to briefly discuss the transition through several periods of time with managing a surge of many patients. This review will focus on the triggering event, injury and illness, location where the care is provided and specifically discuss where the science is today.

  5. What is the impact of Harmattan surges on desert dust emission in North Africa?

    Science.gov (United States)

    Fiedler, Stephanie; Kaplan, Michael L.; Knippertz, Peter

    2015-04-01

    Desert dust aerosols have important implications in the Earth system, but their emission amount has a large model uncertainty. Improving the most important meteorological processes for dust-emitting winds helps to reduce this uncertainty. However, the dominant meteorological mechanisms for the large dust emission during spring remain unclear. This time of year is characterized by mobile, long-lived cyclones and Harmattan surges which are capable to uplift dust aerosol for long-range atmospheric transport. Emission near to the centre of mobile, long-lived cyclones are associated with a small mass of dust emission over the northern Sahara in spring, despite their most frequent occurrence in this season. Harmattan surges are proposed to be more efficient in emitting dust aerosol in spring. These events manifest themselves as a postfrontal strengthening of near-surface winds with a continental impact on dust emission. The present study shows the first long-term climatology of dust emission associated with Harmattan surges over North Africa. Using a newly-developed automated identification, Harmattan surges are statistically analysed in 32 years of ERA-Interim re-analysis from the European Centre for Medium-Range Weather Forecasts. The results show 34 events per year in the annual mean. Spring is herein the most active season with the largest mean number and duration of Harmattan surges, in contrast to summer with virtually no activity. The offline dust emission model by Tegen et al (2002) is used to calculate emissions with ERA-Interim data. Combining these results with the Harmattan surges allows a first quantitative estimate of the associated emission mass. The results highlight that a fraction of 32 % of the total emission is associated with these events, annually and spatially averaged across North Africa. This amount exceeds the annual mean contribution of nocturnal low-level jets to dust emission, which is known as one of the most important drivers for North

  6. Functional connectivity in the basal ganglia network differentiates PD patients from controls

    Science.gov (United States)

    Szewczyk-Krolikowski, Konrad; Menke, Ricarda A.L.; Rolinski, Michal; Duff, Eugene; Salimi-Khorshidi, Gholamreza; Filippini, Nicola; Zamboni, Giovanna; Hu, Michele T.M.

    2014-01-01

    Objective: To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD) on and off medication compared to age- and sex-matched healthy controls (HC), and to validate the findings in a separate cohort of participants with PD. Methods: Participants were scanned with resting-state fMRI (RS-fMRI) at 3T field strength. Resting-state networks were isolated using independent component analysis. A BGN template was derived from 80 elderly HC participants. BGN maps were compared between 19 patients with PD on and off medication in the discovery group and 19 age- and sex-matched controls to identify a threshold for optimal group separation. The threshold was applied to 13 patients with PD (including 5 drug-naive) in the validation group to establish reproducibility of findings. Results: Participants with PD showed reduced functional connectivity with the BGN in a wide range of areas. Administration of medication significantly improved connectivity. Average BGN connectivity differentiated participants with PD from controls with 100% sensitivity and 89.5% specificity. The connectivity threshold was tested on the validation cohort and achieved 85% accuracy. Conclusions: We demonstrate that resting functional connectivity, measured with MRI using an observer-independent method, is reproducibly reduced in the BGN in cognitively intact patients with PD, and increases upon administration of dopaminergic medication. Our results hold promise for RS-fMRI connectivity as a biomarker in early PD. Classification of evidence: This study provides Class III evidence that average connectivity in the BGN as measured by RS-fMRI distinguishes patients with PD from age- and sex-matched controls. PMID:24920856

  7. Prognostic Value of PD-L1 in Breast Cancer: A Meta-Analysis.

    Science.gov (United States)

    Wang, Changjun; Zhu, Hanjiang; Zhou, Yidong; Mao, Feng; Lin, Yan; Pan, Bo; Zhang, Xiaohui; Xu, Qianqian; Huang, Xin; Sun, Qiang

    2017-07-01

    Programmed cell death 1 ligand 1 (PD-L1) is a promising therapeutic target for cancer immunotherapy. However, the correlation between PD-L1 and breast cancer survival remains unclear. Here, we present the first meta-analysis to investigate the prognostic value of PD-L1 in breast cancer. We searched Pubmed, Embase, and Cochrane Central Register of Controlled Trials databases for relevant studies evaluating PD-L1 expression and breast cancer survival. Fixed- and random-effect meta-analyses were conducted based on heterogeneity of included studies. Publication bias was evaluated by funnel plot and Begg's test. Overall, nine relevant studies with 8583 patients were included. PD-L1 overexpression was found in 25.8% of breast cancer patients. PD-L1 (+) associated with several high-risk prognostic indicators, such as ductal cancer (p = 0.037), high tumor grade (p = 0.000), ER negativity (p = 0.000), PR negativity (p = 0.000), HER2 positivity (p = 0.001) and aggressive molecular subtypes (HER2-rich and Basal-like p = 0.000). PD-L1 overexpression had no significant impact on metastasis-free survival (HR 0.924, 95% CI = 0.747-1.141, p = 0.462), disease-free survival (HR 1.122, 95% CI = 0.878-1.434, p = 0.357) and overall specific survival (HR 0.837, 95% CI = 0.640-1.093, p = 0.191), but significantly correlated with shortened overall survival (HR 1.573, 95% CI = 1.010-2.451, p = 0.045). PD-L1 overexpression in breast cancer associates with multiple clinicopathological parameters that indicated poor outcome, and may increase the risk for mortality. Further standardization of PD-L1 assessment assay and well-controlled clinical trials are warranted to clarify its prognostic and therapeutic value. © 2017 Wiley Periodicals, Inc.

  8. Impact of Shed/Soluble targets on the PK/PD of approved therapeutic monoclonal antibodies.

    Science.gov (United States)

    Samineni, Divya; Girish, Sandhya; Li, Chunze

    2016-12-01

    Suboptimal treatment for monoclonal antibodies (mAbs) directed against endogenous circulating soluble targets and the shed extracellular domains (ECD) of the membrane-bound targets is an important clinical concern due to the potential impact of mAbs on the in vivo efficacy and safety. Consequently, there are considerable challenges in the determination of an optimal dose and/or dosing regimen. Areas covered: This review outlines the impact of shed antigen targets from membrane-bound proteins and soluble targets on the PK and/or PD of therapeutic mAbs that have been approved in the last decade. We discuss various bioanalytical techniques that have facilitated the interpretation of the PK/PD properties of therapeutic mAbs and also considered the factors that may impact such measurements. Quantitative approaches include target-mediated PK models and bi- or tri-molecular interaction PK/PD models that describe the relationships between the antibody PK and the ensuing effects on PD biomarkers, to facilitate the mAb PK/PD characterization. Expert commentary: The proper interpretation of PK/PD relationships through the integrated PK/PD modeling and bioanalytical strategy facilitates a mechanistic understanding of the disease processes and dosing regimen optimization, thereby offering insights into developing effective therapeutic regimens. This review provides an overview of the impact of soluble targets or shed ECD on mAb PK/PD properties. We provide examples of quantitative approaches that facilitate the characterization of mAb PK/PD characteristics and their corresponding bioanalytical strategies.

  9. PSP as distinguished from CBD, MSA-P and PD by clinical and imaging differences at an early stage.

    Science.gov (United States)

    Kurata, Tomoko; Kametaka, Satsuki; Ohta, Yasuyuki; Morimoto, Nobutoshi; Deguchi, Shoko; Deguchi, Kentaro; Ikeda, Yoshio; Takao, Yoshiki; Ohta, Taisei; Manabe, Yasuhiro; Sato, Shuhei; Abe, Koji

    2011-01-01

    Because it is often difficult to precisely diagnose and distinguish progressive supranuclear palsy (PSP) from corticobasal degeneration (CBD), multiple system atrophy-parkinsonism (MSA-P) and Parkinson's disease (PD) at the onset of the disease, we compared the patients and clarified the features of these diseases. We compared 77 PSP, 26 CBD, 26 MSA-P and 166 PD patients from clinical and imaging points of view including cerebral blood flow (CBF) in the frontal eye field. The clinical characteristics of PSP were supranuclear gaze disturbance, optokinetic nystagmus (OKN) impairment and falls at the first visit. On head MRI, midbrain tegmentum atrophy was much more frequently detected in PSP than in all of the other groups. Heart-to-mediastinum average count ratio (H/M) in iodine-123 meta-iodobenzyl guanidine ((123)I-MIBG) myocardial scintigraphy was not decreased in PSP, CBD, MSA-P and PD-Yahr 1 (-1), but patients of PD-2, 3, 4 and 5 showed a significant decrease compared with the PSP group. The CBF in the left frontal eye field of PD-3 group and that in right frontal eye field of PD-3 and PD-4 groups were lower than that of PSP group, although other groups showed a tendency without a significant decrease compared with PSP group. PSP is distinguishable from CBD, MSA-P and PD even at the early stage with extra-ocular movement (EOM) disturbance, falls, atrophy of the midbrain tegmentum, and H/M in (123)I-MIBG myocardial scintigraphy, and the reduction of CBF in area 8 could serve as a supplemental diagnostic method for distinguishing PSP from PD-3 or PD-4.

  10. G6PD Deficiency in Turkish Cypriots

    OpenAIRE

    SÖZÜÖZ, Ayşe

    2014-01-01

    1108 Turkish Cypriot men and 318 male labourers from mainland Turkey were screened for G6PD deficiency and haemoglobinopathy traits. The results revealed a 6.7% G6PD deficiency rate in the Turkish Cypriot men and a 1.6% prevalance rate in the Turkish men. The mean haemoglobin level of the G6PD deficient males was approximately 1g/dl lower than that of the non-deficient males.

  11. Gut dysfunction in Parkinson's disease.

    Science.gov (United States)

    Mukherjee, Adreesh; Biswas, Atanu; Das, Shyamal Kumar

    2016-07-07

    Early involvement of gut is observed in Parkinson's disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown. The extensive involvement of the gut in PD even in its early stages has led to the evaluation of enteric α-synuclein as a possible biomarker of early PD. The clinical manifestations of gastrointestinal dysfunction in PD include malnutrition, oral and dental disorders, sialorrhea, dysphagia, gastroparesis, constipation, and defecatory dysfunction. These conditions are quite distressing for the patients and require relevant investigations and adequate management. Treatment usually involves both pharmacological and non-pharmacological measures. One important aspect of gut dysfunction is its contribution to the clinical fluctuations in PD. Dysphagia and gastroparesis lead to inadequate absorption of oral anti-PD medications. These lead to response fluctuations, particularly delayed-on and no-on, and there is significant relationship between levodopa pharmacokinetics and gastric emptying in patients with PD. Therefore, in such cases, alternative routes of administration or drug delivery systems may be required.

  12. Odor recognition memory is not idepentently impaired in Parkinson's disease

    NARCIS (Netherlands)

    Boesveldt, S.; Muinck Keizer, de R.J.O.; Wolters, E.C.H.; Berendse, H.W.

    2009-01-01

    The results of previous studies in small groups of Parkinson's disease (PD) patients are inconclusive with regard to the presence of an odor recognition memory impairment in PD. The aim of the present study was to investigate odor recognition memory in PD in a larger group of patients. Odor

  13. Dopaminergic medication affects choice bias in Parkinson's disease

    NARCIS (Netherlands)

    Nuland, A.J.M. van; Helmich, R.C.G.; Dirkx, M.F.M.; Zach, H.; Bloem, B.R.; Toni, I.; Cools, R.; Ouden, H.E.M. den

    2016-01-01

    Objective: Assess dopaminergic effects on choice bias in Parkinson's disease (PD). Background: Bradykinesia, rigidity and resting tremor are the core symptoms of PD, but many patients also suffer from cognitive dysfunction. For instance, PD patients have an increased tendency to learn from aversive

  14. Cognitive deficits in Parkinson’s disease: current perspectives

    Directory of Open Access Journals (Sweden)

    Cosgrove J

    2018-01-01

    Full Text Available Jeremy Cosgrove, Jane Elizabeth Alty Department of Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK Abstract: Cognitive dysfunction is a common and significant non-motor symptom of Parkinson’s disease (PD. PD mild cognitive impairment (PD-MCI is evident in approximately one-quarter of patients at the time of PD diagnosis, and half of PD patients have progressed to PD dementia (PDD after 10 years. The transition to PDD from PD-MCI is not linear and may depend on the facets of cognition affected. Despite increased understanding of pathological, neurotransmitter and genetic drivers, there are no proven pharmacological treatments for PD-MCI and those licensed for PDD are of modest benefit only. Biomarkers to predict those most at risk of developing PDD are under investigation and are likely to be essential so that early and individualized treatment can be provided. Keywords: Parkinson’s disease, mild cognitive impairment, dementia

  15. Immuno-pathogenesis of Periodontal Disease: Current and Emerging Paradigms.

    Science.gov (United States)

    Huang, Nasi; Gibson, Frank C

    2014-06-01

    Periodontal disease (PD) is a highly complex disease involving many factors; however, two principal facets central to initiation and progression of the majority of PD are the composition of the microbes in the sub-gingival plaque, and the host immune response to these organisms. Numerous studies point to the complexity of PD, and to the fact that despite innate and adaptive immune activation, and resultant inflammation, our immune response fails to cure disease. Stunning new findings have begun to clarify several complexities of the host-pathogen interaction of PD pointing to key roles for microbial dysboisis and immune imbalance in the pathogenesis of disease. Furthermore, these investigations have identified novel translational opportunities to intercede in PD treatment. In this review we will highlight a select few recent findings in innate and adaptive immunity, and host pathogen interactions of PD at a micro-environmental level that may have profound impact on PD progression.

  16. Flow Characterization and Dynamic Analysis of a Radial Compressor with Passive Method of Surge Control

    Science.gov (United States)

    Guillou, Erwann

    Due to recent emission regulations, the use of turbochargers for force induction of internal combustion engines has increased. Actually, the trend in diesel engines is to downsize the engine by use of turbochargers that operate at higher pressure ratio. Unfortunately, increasing the rotational speed tends to reduce the turbocharger radial compressor range of operation which is limited at low mass flow rate by the occurrence of surge. In order to extent the operability of turbochargers, compressor housings can be equipped with a passive surge control device also known as ported shroud. This specific casing treatment has been demonstrated to enhance surge margin with minor negative impact on the compressor efficiency. However, the actual working mechanisms of the bypass system remain not well understood. In order to optimize the design of the ported shroud, it is then crucial to identify the dynamic flow changes induced by the implementation of the device to control instabilities. Experimental methods were used to assess the development of instabilities from stable, stall and eventually surge regimes of a ported shroud centrifugal compressor. Systematic comparison was conducted with the same compressor design without ported shroud. Hence, the full pressure dynamic survey of both compressors' performance characteristics converged toward two different and probably interrelated driving mechanisms to the development and/or propagation of unsteadiness within each compressor. One related the pressure disturbances at the compressor inlet, and notably the more apparent development of perturbations in the non-ported compressor impeller, whereas the other was attributed to the pressure distortions induced by the presence of the tongue in the asymmetric design of the compressor volute. Specific points of operation were selected to carry out planar flow measurements. At normal working, both standard and stereoscopic particle imaging velocimetry (PIV) measurements were performed

  17. Influence of Northeast Monsoon cold surges on air quality in Southeast Asia

    Science.gov (United States)

    Ashfold, M. J.; Latif, M. T.; Samah, A. A.; Mead, M. I.; Harris, N. R. P.

    2017-10-01

    Ozone (O3) is an important ground-level pollutant. O3 levels and emissions of O3 precursors have increased significantly over recent decades in East Asia and export of this O3 eastward across the Pacific Ocean is well documented. Here we show that East Asian O3 is also transported southward to tropical Southeast (SE) Asia during the Northeast Monsoon (NEM) season (defined as November to February), and that this transport pathway is especially strong during 'cold surges'. Our analysis employs reanalysis data and measurements from surface sites in Peninsular Malaysia, both covering 2003-2012, along with trajectory calculations. Using a cold surge index (northerly winds at 925 hPa averaged over 105-110°E, 5°N) to define sub-seasonal strengthening of the NEM winds, we find the largest changes in a region covering much of the Indochinese Peninsula and surrounding seas. Here, the levels of O3 and another key pollutant, carbon monoxide, calculated by the Monitoring Atmospheric Composition and Climate (MACC) Reanalysis are on average elevated by, respectively, >40% (∼15 ppb) and >60% (∼80 ppb) during cold surges. Further, in the broader region of SE Asia local afternoon exceedances of the World Health Organization's air quality guideline for O3 (100 μg m-3, or ∼50 ppb, averaged over 8 h) largely occur during these cold surges. Day-to-day variations in available O3 observations at surface sites on the east coast of Peninsular Malaysia and in corresponding parts of the MACC Reanalysis are similar, and are clearly linked to cold surges. However, observed O3 levels are typically ∼10-20 ppb lower than the MACC Reanalysis. We show that these observations are also subject to influence from local urban pollution. In agreement with past work, we find year-to-year variations in cold surge activity related to the El Nino-Southern Oscillation (ENSO), but this does not appear to be the dominant influence of ENSO on atmospheric composition in this region. Overall, our study

  18. Effect of monensin on the estrogen-induced LH surge in prepuberal heifers.

    Science.gov (United States)

    Randel, R D; Rutter, L M; Rhodes, R D

    1982-04-01

    The effect of dietary monensin on the luteinizing hormone (LH) surge following estradiol-17 beta (E2) injection was investigated in prepuberal Simmental X Brahman-Hereford heifers. Ten heifers, weighing approximately 260 kg and approximately 10 mo of age, were equally divided by age and weight into two groups: control (C) heifers each received 1.8 kg/d of a concentrate diet plus Coastal bermudagrass hay ad libitum; monensin (M) heifers each received the same diet plus 200 mg monensin/d. All heifers were maintained in dry lots on their respective diets for 14 d before the E2 challenge. On d 15, all heifers were injected in with 5 mg of E2 in corn oil. Blood samples were collected via tail vessel puncture immediately before E2 injection and at 2-h intervals until 48 h after the E2 injection. The samples were processed for serum and stored at -20 degrees C until LH concentrations were measured by radioimmunoassay. Mean concentrations of LH in serum differed (P less than .005) between C and M heifers and with time after E2 injection. A treatment X sampling period interaction (P less than .10) indicated that maximum serum concentrations of LH (LH surge) were detected earlier (P less than .001) for M (17.2 +/- 1.8 h) than C (27.0 +/- 6.0 h) heifers after the E2 injection. When the data were arrayed relative to the time of the LH surge, treatment (P less than .05) and sampling period (P less than .001) effects were significant, but a treatment X sampling period interaction was not detected. Peak LH concentration was 23.1 +/- 3.0 ng/ml for M heifers and 21.6+/- 4.2 ng/ml for controls (P greater than .10). Duration of the LH surge was 8.0 +/- .9 h in M heifers and 4.8 +/- 1.6 h in C heifers (P less than .001). Area under the LH surge was greater (P less than .001) in M heifers than in control heifers. We conclude that dietary monensin altered the estrogen-induced LH surge in prepuberal heifers.

  19. [Perioperative management of Parkinson's disease].

    Science.gov (United States)

    Mariscal, A; Medrano, I Hernández; Cánovas, A Alonso; Lobo, E; Loinaz, C; Vela, L; Espiga, P García-Ruiz; Castrillo, J C Martínez

    2012-01-01

    One of the particular characteristics of Parkinson's disease (PD) is the wide clinical variation as regards the treatment that can be found in the same patient. This occurs with specific treatment for PD, as well as with other drug groups that can make motor function worse. For this reason, the perioperative management of PD requires experience and above all appropriate planning. In this article, the peculiarities of PD and its treatment are reviewed, and a strategy is set out for the perioperative management of these patients. Copyright © 2010 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  20. Circadian dysregulation in Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Aleksandar Videnovic

    2017-01-01

    Full Text Available Parkinson's disease (PD is the second most common neurodegenerative disorder that affects over one million individuals in the US alone. PD is characterized by a plethora of motor and non-motor manifestations, resulting from a progressive degeneration of dopaminergic neurons and disbalance of several other neurotransmitters. A growing body of evidence points to significant alterations of the circadian system in PD. This is not surprising given the pivotal role that dopamine plays in circadian regulation as well as the role of circadian influences in dopamine metabolism. In this review we present basic and clinical investigations that examined the function of the circadian system in PD.

  1. Remote-sensing-based analysis of the 1996 surge of Northern Inylchek Glacier, central Tien Shan, Kyrgyzstan

    Science.gov (United States)

    Häusler, Hermann; Ng, Felix; Kopecny, Alexander; Leber, Diethard

    2016-11-01

    The evolution of Northern Inylchek Glacier and its proglacial lake - Upper Lake Merzbacher - during its 1996 surge and the surrounding decades is analyzed with remote sensing imagery. Overall retreat of the glacier from 1943 to 1996 enlarged the lake to 4 km long and ≈ 100 m deep. The surge in 1996 initiated between 12 September and 7 October and advanced the glacier by 3.7 km to override most of Upper Lake Merzbacher. The surge phase probably ended in December 1996 and involved mean flow velocities across the lower trunk of the glacier that reached 50 m d- 1 over a 32-day period. Water displaced by the surge from Upper Lake Merzbacher, totalling 1.5 × 108 m3 in volume, accelerated filling of Lower Lake Merzbacher downvalley and helped trigger this marginal ice-dammed lake to outburst in a jökulhlaup around late November/early December. The characteristics and duration of the surge render it as similar to temperate glacier surges elsewhere. It may have been facilitated by low basal friction caused by water-saturated sediments in the upper lake bed. Furthermore, bathymetric measurements show that the surge evacuated much sediment into the upper lake, causing its depth to reduce from 20 to 30 m in 1996 to 8 m by 2005 and 2 m by 2011; the corresponding deposition rates imply glacier-catchment specific mean sediment yields of 1.4 to 3.4 × 103 Mg km- 2 a- 1 in the years after the surge. Our study documents novel interactions within a cascade system of glaciers and lakes that exhibits surging and outburst-flood behavior.

  2. Sleep Dysfunction in Parkinson's Disease.

    Science.gov (United States)

    Falup-Pecurariu, Cristian; Diaconu, Ştefania

    2017-01-01

    The spectrum of sleep problems in Parkinson's disease (PD) is broad. These symptoms are recognized as being clinically relevant by the PD patients and may seriously affect their quality of life. Some studies reveal the occurrence of sleep disorders in more than half of the PD patients. The etiology is multifactorial and it mainly involves the degeneration of the sleep-regulating structures. Sleep disorders in PD can be classified into: disturbances of sleep and disturbances of wakefulness. Generic and specific scales were designed to help the screening and evaluation of sleep dysfunction. Further assessment can be done using sleep recording techniques, like actigraphy or polysomnography. All types of sleep disturbances may be encountered in PD: insomnia, excessive daytime sleepiness, rapid eye movement sleep behavior disorders, and restless legs syndrome. This chapter will focus on reviewing the main characteristics, pathophysiology, assessment, and management of the most frequent sleep disturbances encountered in PD. © 2017 Elsevier Inc. All rights reserved.

  3. Brain MRI in Parkinson's disease

    NARCIS (Netherlands)

    Meijer, F.J.A.; Goraj, B.M.

    2014-01-01

    In this review article, conventional brain MRI and advanced MRI techniques in Parkinson`s disease (PD) are discussed, with emphasis on clinical relevance. Conventional brain MRI sequences generally demonstrate limited abnormalities specific for PD and in clinical practice brain MRI is mainly used to

  4. Skin disorders in Parkinson's disease

    DEFF Research Database (Denmark)

    Ravn, Astrid-Helene; Thyssen, Jacob P; Egeberg, Alexander

    2017-01-01

    Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations...

  5. Peritoneal dialysis and cardiovascular disease

    NARCIS (Netherlands)

    Balafa, O.; Krediet, R. T.

    2012-01-01

    Cardiovascular (CV) death is the most frequent cause of dying in peritoneal dialysis (PD) patients. Risk factors include not only those that can be present in the general population, but also those related to the presence of end-stage renal disease (ESRD) and factors that are specific for PD

  6. Genetic comorbidities in Parkinson's disease

    NARCIS (Netherlands)

    Nalls, Mike A.; Saad, Mohamad; Noyce, Alastair J.; Keller, Margaux F.; Schrag, Anette; Bestwick, Jonathan P.; Traynor, Bryan J.; Gibbs, J. Raphael; Hernandez, Dena G.; Cookson, Mark R.; Morris, Huw R.; Williams, Nigel; Gasser, Thomas; Heutink, Peter; Wood, Nick; Hardy, John; Martinez, Maria; Singleton, Andrew B.; Nalls, Mike; Plagnol, Vincent; Sharma, Manu; Sheerin, Una-Marie; Simón-Sánchez, Javier; Schulte, Claudia; Lesage, Suzanne; Sveinbjörnsdóttir, Sigurlaug; Arepalli, Sampath; Barker, Roger; Ben-Shlomo, Yoav; Berendse, Henk W.; Berg, Daniela; Bhatia, Kailash; de Bie, Rob M. A.; Biffi, Alessandro; Bloem, Bas; Bochdanovits, Zoltan; Bonin, Michael; Bras, Jose M.; Brockmann, Kathrin; Brooks, Janet; Burn, David J.; Charlesworth, Gavin; Chen, Honglei; Chinnery, Patrick F.; Chong, Sean; Clarke, Carl E.; Cooper, J. Mark; Corvol, Jean Christophe; Counsell, Carl; Damier, Philippe; Dartigues, Jean-François; Deloukas, Panos; Deuschl, Günther; Dexter, David T.; van Dijk, Karin D.; Dillman, Allissa; Durif, Frank; Dürr, Alexandra; Edkins, Sarah; Evans, Jonathan R.; Foltynie, Thomas; Gao, Jianjun; Gardner, Michelle; Goate, Alison; Gray, Emma; Guerreiro, Rita; Gústafsson, Ómar; Harris, Clare; van Hilten, Jacobus J.; Hofman, Albert; Hollenbeck, Albert; Holton, Janice; Hu, Michele; Huang, Xuemei; Huber, Heiko; Hudson, Gavin; Hunt, Sarah E.; Huttenlocher, Johanna; Illig, Thomas; Jónsson, Pálmi V.; Lambert, Jean-Charles; Langford, Cordelia; Lees, Andrew; Lichtner, Peter; Limousin, Patricia; Lopez, Grisel; Lorenz, Delia; McNeill, Alisdair; Moorby, Catriona; Moore, Matthew; Morrison, Karen E.; Mudanohwo, Ese; O'Sullivan, Sean S.; Pearson, Justin; Perlmutter, Joel S.; Pétursson, Hjörvar; Pollak, Pierre; Post, Bart; Potter, Simon; Ravina, Bernard; Revesz, Tamas; Riess, Olaf; Rivadeneira, Fernando; Rizzu, Patrizia; Ryten, Mina; Sawcer, Stephen; Schapira, Anthony; Scheffer, Hans; Shaw, Karen; Shoulson, Ira; Sidransky, Ellen; Smith, Colin; Spencer, Chris C. A.; Stefánsson, Hreinn; Steinberg, Stacy; Stockton, Joanna D.; Strange, Amy; Talbot, Kevin; Tanner, Carlie M.; Tashakkori-Ghanbaria, Avazeh; Tison, François; Trabzuni, Daniah; Uitterlinden, André G.; Velseboer, Daan; Vidailhet, Marie; Walker, Robert; van de Warrenburg, Bart; Wickremaratchi, Mirdhu; Williams-Gray, Caroline H.; Winder-Rhodes, Sophie; Stefánsson, Kári; Brice, Alexis; Wood, Nicholas W.; Donnelly, Peter; Barroso, Ines; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S.; Mathew, Christopher G.; Palmer, N. A.; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J.; Trembath, Richard C.; Viswanathan, Ananth C.; Band, Gavin; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard; Su, Zhan; Vukcevic, Damjan; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J.; Dronov, Serge; Gillman, Matthew; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T.; Liddle, Jennifer; Potter, Simon C.; Ravindrarajah, Radhi; Ricketts, Michelle; Waller, Matthew; Weston, Paul; Widaa, Sara; Whittaker, Pamela; McCarthy, Mark I.; Nalls, Michael A.; Zonderman, Alan B.; Ferrucci, Luigi; Johnson, Robert; Longo, Dan L.; O'Brien, Richard; Traynor, Bryan; Troncoso, Juan; van der Brug, Marcel; Zielke, Ronald H.; Weale, Michael E.; Ramasamy, Adaikalavan; Walker, Rober

    2014-01-01

    Parkinson's disease (PD) has a number of known genetic risk factors. Clinical and epidemiological studies have suggested the existence of intermediate factors that may be associated with additional risk of PD. We construct genetic risk profiles for additional epidemiological and clinical factors

  7. Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients withEGFR-Mutant Non-small Cell Lung Cancer.

    Science.gov (United States)

    Cho, Jong Ho; Zhou, Wei; Choi, Yoon-La; Sun, Jong-Mu; Choi, Hyejoo; Kim, Tae-Eun; Dolled-Filhart, Marisa; Emancipator, Kenneth; Rutkowski, Mary Anne; Kim, Jhingook

    2018-01-01

    Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor ( EGFR )-mutant non-small cell lung cancer (NSCLC). We retrospectively evaluated the relationship between PD-L1 expression and recurrence-free survival (RFS) and overall survival in 319 patients with EGFR -mutant NSCLC who were treated at Samsung Medical Center from 2006 to 2014. Membranous PD-L1 expression on tumor cells was measured using the PD-L1 IHC 22C3 pharmDx antibody and reported as tumor proportion score (TPS). Kaplan-Meier methods, log-rank test, and Cox proportional hazards models were used for survival analysis. All patients had ≥1 EGFR mutation-54% in exon 19 and 39% in exon 21. Overall, 51% of patients had PD-L1-positive tumors. The prevalence of PD-L1 positivity was higher among patients with stages II-IV versus stage I disease (64% vs. 44%) and among patients with other EGFR mutations (75%) than with L858R mutation (39%) or exon 19 deletion (52%). PD-L1 positivity was associated with shorter RFS, with an adjusted hazard ratio of 1.52 (95% confidence interval [CI], 0.81 to 2.84; median, 18 months) for the PD-L1 TPS ≥ 50% group, 1.51 (95% CI, 1.02 to 2.21; median, 31 months) for the PD-L1 TPS 1%-49% group, and 1.51 (95% CI, 1.05 to 2.18) for the combined PD-L1-positive groups (TPS ≥ 1%) compared with the PD-L1-negative group (median, 35 months). PD-L1 expression is associated with disease stage and type of EGFR mutation. PD-L1 positivity might be associated with worse RFS among patients with surgically treated EGFR -mutant NSCLC.

  8. Psychiatric care in Parkinson's disease.

    Science.gov (United States)

    Quelhas, Rosa

    2013-03-01

    Parkinson's disease (PD) is a degenerative and disabling disease in which medical providers focus mainly on ameliorating problems in day-to-day functioning. This review summarizes current knowledge about the efficacy and tolerability of psychopharmacological agents in the treatment of depression, anxiety, psychosis, and insomnia in patients with PD. Recommended or promising nonpharmacological interventions are also reviewed. Studies were identified using computerized searches, with further references obtained from the bibliographies of the reviewed articles. Findings in the research literature provide growing evidence concerning the antidepressant treatment of patients with PD. Psychoeducational interventions for managing depression and anxiety symptoms also appear promising. Music therapy has proven to be particularly effective for patients with PD. Psychosis is common in patients with PD. When psychosis is induced by antiparkinson drugs, a dose reduction can be considered, but it is seldom successful. Patients with PD do not generally tolerate conventional antipsychotic medications, justifying evaluation of newer atypical agents in this population. Cholinesterase inhibitors have also become increasingly important in the treatment of PD in recent years. Finally, insomnia is a very frequent complaint in patients with PD and may also contribute to the development of depression. Patients should be encouraged to improve sleep hygiene and use behavioral interventions. Definitive trials of treatments for sleep disorders in this population are also warranted. Therapeutic approaches to the treatment of PD and its associated psychiatric symptoms must be individualized and may involve a combination of antiparkinson drugs, psychopharmacological treatment, and/or psychotherapeutic interventions.

  9. Reading comprehension in Parkinson's disease.

    Science.gov (United States)

    Murray, Laura L; Rutledge, Stefanie

    2014-05-01

    Although individuals with Parkinson's disease (PD) self-report reading problems and experience difficulties in cognitive-linguistic functions that support discourse-level reading, prior research has primarily focused on sentence-level processing and auditory comprehension. Accordingly, the authors investigated the presence and nature of reading comprehension in PD, hypothesizing that (a) individuals with PD would display impaired accuracy and/or speed on reading comprehension tests and (b) reading performances would be correlated with cognitive test results. Eleven adults with PD and 9 age- and education-matched control participants completed tests that evaluated reading comprehension; general language and cognitive abilities; and aspects of attention, memory, and executive functioning. The PD group obtained significantly lower scores on several, but not all, reading comprehension, language, and cognitive measures. Memory, language, and disease severity were significantly correlated with reading comprehension for the PD group. Individuals in the early stages of PD without dementia or broad cognitive deficits can display reading comprehension difficulties, particularly for high- versus basic-level reading tasks. These reading difficulties are most closely related to memory, high-level language, and PD symptom severity status. The findings warrant additional research to delineate further the types and nature of reading comprehension impairments experienced by individuals with PD.

  10. Definition of testing procedures to check the performance of ZnO surge arresters in different environmental conditions

    International Nuclear Information System (INIS)

    Bargigia, A.; De Nigris, M.; Pigini, A.; Sironi, A.

    1992-01-01

    The performance of surge arresters under different environmental conditions involves three main aspects: the strength of the external insulation; heating of the internal active part of the surge arrester associated with voltage unbalance along the arrester that takes place with the external surface contaminated and wetted; ageing of the resistors blocks associated with chemical alterations that may occur inside the arrester under different environmental conditions lasting for a long time. This paper discusses the research work conducted in Italy to investigate all three aspects of the performance of ZnO surge arresters under different environmental conditions

  11. The influence of sea surface temperature on the intensity and associated storm surge of tropical cyclone Yasi: a sensitivity study

    Science.gov (United States)

    Lavender, Sally L.; Hoeke, Ron K.; Abbs, Deborah J.

    2018-03-01

    Tropical cyclones (TCs) result in widespread damage associated with strong winds, heavy rainfall and storm surge. TC Yasi was one of the most powerful TCs to impact the Queensland coast since records began. Prior to Yasi, the SSTs in the Coral Sea were higher than average by 1-2 °C, primarily due to the 2010/2011 La Niña event. In this study, a conceptually simple idealised sensitivity analysis is performed using a high-resolution regional model to gain insight into the influence of SST on the track, size, intensity and associated rainfall of TC Yasi. A set of nine simulations with uniform SST anomalies of between -4 and 4 °C applied to the observed SSTs are analysed. The resulting surface winds and pressure are used to force a barotropic storm surge model to examine the influence of SST on the associated storm surge of TC Yasi. An increase in SST results in an increase in intensity, precipitation and integrated kinetic energy of the storm; however, there is little influence on track prior to landfall. In addition to an increase in precipitation, there is a change in the spatial distribution of precipitation as the SST increases. Decreases in SSTs result in an increase in the radius of maximum winds due to an increase in the asymmetry of the storm, although the radius of gale-force winds decreases. These changes in the TC characteristics also lead to changes in the associated storm surge. Generally, cooler (warmer) SSTs lead to reduced (enhanced) maximum storm surges. However, the increase in surge reaches a maximum with an increase in SST of 2 °C. Any further increase in SST does not affect the maximum surge but the total area and duration of the simulated surge increases with increasing upper ocean temperatures. A large decrease in maximum storm surge height occurs when a negative SST anomaly is applied, suggesting if TC Yasi had occurred during non-La Niña conditions the associated storm surge may have been greatly diminished, with a decrease in storm surge

  12. The electrochemical reduction of PdCl42- and PdCl62- in polyaniline: Influence of Pd deposit morphology on methanol oxidation in alkaline solution

    International Nuclear Information System (INIS)

    Hatchett, David W.; Millick, Nicole M.; Kinyanjui, John M.; Pookpanratana, Sujitra; Baer, Marcus; Hofmann, Timo; Luinetti, Alessio; Heske, Clemens

    2011-01-01

    Graphical abstract: Display Omitted Highlights: → The synthesis of PANI/Pd composites using PdCl 4 2- and PdCl 6 2- is achieved. → Conductivity of PANI/Pd composites is observed in alkaline solution (pH ∼ 14). → Oxidation of methanol at PANI/Pd is influenced to be the Pd surface morphology. → Surface poisoning is minimized for PANI/Pd produced using PdCl 4 2- . → The Pd metal acts as a solid state dopant in PANI. - Abstract: The controlled uptake and electrochemical reduction of metal precursors PdCl 4 2- and PdCl 6 2- in polyaniline (PANI) is demonstrated. The formation of PANI/Pd composites is achieved with a reduction in proton doping and an increase in the oxidation of the polymer with Pd deposits physically blocking the nitrogen groups. High surface area filaments (PdCl 4 2- ) or a rough encapsulation (PdCl 6 2- ) of Pd metal on PANI are obtained. The structural differences highlight the influence of the metal precursor oxidation state on the morphology of the Pd deposits in PANI. Thermal gravimetric analysis provides an estimate of the Pd content for each composite of ∼40%. X-ray Photoelectron Spectroscopy and X-ray-excited Auger Electron Spectroscopy analyses confirm the deposition of Pd metal. The catalytic oxidation of methanol was demonstrated for both PANI/Pd composites in alkaline solutions that prohibit proton doping of the polymer. The data indicates that Pd metal acts as a solid-state dopant that may delocalize the charge on the polymer backbone to maintain conductivity. Methanol oxidation at PANI/Pd composites produced using PdCl 4 2- was enhanced relative to the composite produced using PdCl 6 2- and a planar Pd electrode. Comparison of PANI/Pd composite produced using PdCl 4 2- with other Pd catalysts from the literature indicates surface poisoning is reduced when Pd is coupled with the polymer. The composite is robust and stable in alkaline solution with the charge density decreasing by 5% on the positive scan and 13% on the

  13. Parkinson's disease severity and motor subtype influence physical capacity components

    OpenAIRE

    Pereira,Marcelo Pinto; Pelicioni,Paulo Henrique Silva; Gobbi,Lilian Teresa Bucken

    2013-01-01

    The severity of Parkinson's disease (PD) and PD's motor subtypes influence the components of physical capacity. The aim of this study was to investigate the impact of both PD severity and motor subtype in the performance of these components. Thirty-six PD patients were assigned into four groups: Tremor (TD) initial and TD mild, akinetic-rigid (AR) initial, and AR mild. Patients' strength, balance, coordination, mobility and aerobic capacity were evaluated and groups were compared using a two-...

  14. Electrophysiological Evaluation of Oropharyngeal Dysphagia in Parkinson’s Disease

    OpenAIRE

    Ertekin, Cumhur

    2014-01-01

    Parkinson’s disease (PD) is a chronic, neurodegenerative movement disorder that typically affects elderly patients. Swallowing disorders are highly prevalent in PD and can have grave consequences, including pneumonia, malnutrition, dehydration and mortality. Neurogenic dysphagia in PD can manifest with both overt clinical symptoms or silent dysphagia. Regardless, early diagnosis and objective follow-up of dysphagia in PD is crucial for timely and appropriate care for these patients. In this r...

  15. Framework for Understanding Balance Dysfunction in Parkinson’s Disease

    Science.gov (United States)

    Schoneburg, Bernadette; Mancini, Martina; Horak, Fay; Nutt, John G.

    2013-01-01

    People with Parkinson’s disease (PD) suffer from progressive impairment in their mobility. Locomotor and balance dysfunction that impairs mobility in PD is an important cause of physical and psychosocial disability. The recognition and evaluation of balance dysfunction by the clinician is an essential component of managing PD. In this review, we describe a framework for understanding balance dysfunction in PD to help clinicians recognize patients that are at risk for falling and impaired mobility. PMID:23925954

  16. Facial Emotion Recognition Impairment in Patients with Parkinson's Disease and Isolated Apathy

    Directory of Open Access Journals (Sweden)

    Mercè Martínez-Corral

    2010-01-01

    Full Text Available Apathy is a frequent feature of Parkinson's disease (PD, usually related with executive dysfunction. However, in a subgroup of PD patients apathy may represent the only or predominant neuropsychiatric feature. To understand the mechanisms underlying apathy in PD, we investigated emotional processing in PD patients with and without apathy and in healthy controls (HC, assessed by a facial emotion recognition task (FERT. We excluded PD patients with cognitive impairment, depression, other affective disturbances and previous surgery for PD. PD patients with apathy scored significantly worse in the FERT, performing worse in fear, anger, and sadness recognition. No differences, however, were found between nonapathetic PD patients and HC. These findings suggest the existence of a disruption of emotional-affective processing in cognitive preserved PD patients with apathy. To identify specific dysfunction of limbic structures in PD, patients with isolated apathy may have therapeutic and prognostic implications.

  17. Optimal Control of a Surge-Mode WEC in Random Waves

    Energy Technology Data Exchange (ETDEWEB)

    Chertok, Allan [Resolute Marine Energy, Inc., Boston, MA (United States); Ceberio, Olivier [Resolute Marine Energy, Inc., Boston, MA (United States); Staby, Bill [Resolute Marine Energy, Inc., Boston, MA (United States); Previsic, Mirko [Re Vision Consulting, Sacramento, CA (United States); Scruggs, Jeffrey [Univ. of Michigan, Ann Arbor, MI (United States); Van de Ven, James [Univ. of Minnesota, Minneapolis, MN (United States)

    2016-08-30

    The objective of this project was to develop one or more real-time feedback and feed-forward (MPC) control algorithms for an Oscillating Surge Wave Converter (OSWC) developed by RME called SurgeWEC™ that leverages recent innovations in wave energy converter (WEC) control theory to maximize power production in random wave environments. The control algorithms synthesized innovations in dynamic programming and nonlinear wave dynamics using anticipatory wave sensors and localized sensor measurements; e.g. position and velocity of the WEC Power Take Off (PTO), with predictive wave forecasting data. The result was an advanced control system that uses feedback or feed-forward data from an array of sensor channels comprised of both localized and deployed sensors fused into a single decision process that optimally compensates for uncertainties in the system dynamics, wave forecasts, and sensor measurement errors.

  18. Microstructural evaluation of a varistor block utilized in high voltage surge arresters

    International Nuclear Information System (INIS)

    Andrade, J.M. de; Dias, R.; Furtado, J.G. de M.; Assuncao, F.C.R.

    2010-01-01

    Varistor is a semiconductor ceramic device characterized to have a high non-linear electrical resistance, it is used as active element of surge arresters with purpose of protecting of electro-electronics systems. Its properties are directly dependents of chemical composition and microstructural characteristics, such as grain size, porosity, twins and phases distribution. This work has the objective to characterize microstructurally a commercial varistor block of ZnO used in high voltage surge arrest and from this characterization to infer aspects about of its electrical macroscopic performance. DRX and SEM-EDS were used for microstructural analysis. The microstructural evaluation allows pointing the critical points of microstructure and, suggest relevant aspects to the improvement of commercial varistor microstructure, optimizing the electrothermal behavior of the device. (author)

  19. Investigation of Overvoltage Phenomena due to Lightning Surge in Low Voltage Wiring

    Science.gov (United States)

    Tan, Akiyoshi; Koga, Soichi; Vasa, Nilesh J.; Yokoyama, Shigeru; Hosokawa, Takeshi; Sawabe, Kimihide; Yoshioka, Tetsuo; Soeda, Masahiro

    In order to understand overvoltage phenomena due to the lightning surge in a low voltage wiring on a scale model of a structure, the load circuit of electrical appliances at the end of cable with circuit elements, such as resistors, capacitors and inductors, was simulated and the response at the end of cable was studied. Furthermore experimental results were compared with those of the digital simulation using EMTP (Electro-Magnetic Transients Program). The variation in the voltage waveform generated at the end of cable according to the state of the load of an electrical equipment was confirmed based on experiments and simulations. However, when a varistor (Surge Protective Device) was inserted at the end of cable, the voltage amplitude was clamped by the varistor irrespective of the load circuit.

  20. Estimation of the Frequency of Instantaneous Voltage Drops Dependent on Arrangement of Line Surge Arresters

    Science.gov (United States)

    Kawamura, Hironao; Kozuka, Masahiro; Itamoto, Naoki; Shinjo, Kazuo; Ishii, Masaru

    Lightning faults on transmission lines often cause instantaneous voltage drops in power systems. Influences of instantaneous voltage drops become increasingly serious in high technology industries etc. As countermeasures of instantaneous voltage drops, uninterruptible power supplies (UPS) are employed. On the other hand, line surge arresters are installed on transmission lines increasingly as one of the effective countermeasures of double-circuit faults caused by lightning strokes. Additionally, the arresters are effective as one of the reduction methods for the frequency of instantaneous voltage drops. In this paper, the frequency of instantaneous voltage drops reduced by installation of line surge arresters on transmission lines is estimated by employing EMTP analysis. Also, the accuracy of the method in estimating the frequency of instantaneous voltage drops in power systems is evaluated through comparison with experience.

  1. Application of Powell's optimization method to surge arrester circuit models' parameters

    Energy Technology Data Exchange (ETDEWEB)

    Christodoulou, C.A.; Stathopulos, I.A. [National Technical University of Athens, School of Electrical and Computer Engineering, 9 Iroon Politechniou St., Zografou Campus, 157 80 Athens (Greece); Vita, V.; Ekonomou, L.; Chatzarakis, G.E. [A.S.PE.T.E. - School of Pedagogical and Technological Education, Department of Electrical Engineering Educators, N. Heraklion, 141 21 Athens (Greece)

    2010-08-15

    Powell's optimization method has been used for the evaluation of the surge arrester models parameters. The proper modelling of metal-oxide surge arresters and the right selection of equivalent circuit parameters are very significant issues, since quality and reliability of lightning performance studies can be improved with the more efficient representation of the arresters' dynamic behavior. The proposed approach selects optimum arrester model equivalent circuit parameter values, minimizing the error between the simulated peak residual voltage value and this given by the manufacturer. Application of the method in performed on a 120 kV metal oxide arrester. The use of the obtained optimum parameter values reduces significantly the relative error between the simulated and manufacturer's peak residual voltage value, presenting the effectiveness of the method. (author)

  2. Improving Short-Range Ensemble Kalman Storm Surge Forecasting Using Robust Adaptive Inflation

    KAUST Repository

    Altaf, Muhammad

    2013-08-01

    This paper presents a robust ensemble filtering methodology for storm surge forecasting based on the singular evolutive interpolated Kalman (SEIK) filter, which has been implemented in the framework of the H∞ filter. By design, an H∞ filter is more robust than the common Kalman filter in the sense that the estimation error in the H∞ filter has, in general, a finite growth rate with respect to the uncertainties in assimilation. The computational hydrodynamical model used in this study is the Advanced Circulation (ADCIRC) model. The authors assimilate data obtained from Hurricanes Katrina and Ike as test cases. The results clearly show that the H∞-based SEIK filter provides more accurate short-range forecasts of storm surge compared to recently reported data assimilation results resulting from the standard SEIK filter.

  3. The electrical resistivities of liquid Pd-Bi alloys and the band structure of crystalline β-PdBi2 and PdBi

    NARCIS (Netherlands)

    Xu, R.; Groot, R.A. de; Lugt, W. van der

    1992-01-01

    Measurements of the electrical resistivity ρ of liquid Pd-Bi alloys as a function of temperature have been performed in the concentration range from pure bismuth to 60 at.% Pd. Plotted as a function of composition, the resistivity of Pd-Bi exhibits a maximum near 30 at.% Pd. At this maximum the

  4. Possibility Of Generating Significant Storm Surge On The Western Seaboard Of Metro Manila, Philippines

    Science.gov (United States)

    Suarez, J. K. B.; Santiago, J. T.; Tablazon, J. P.; Dasallas, L. L.; Goting, P. G.; Lagmay, A. M. A.

    2016-12-01

    The Philippines, located in the Northwestern Pacific Typhoon gateway to Asia, is considered one of the most susceptible to tropical cyclone related hazards. One of the most disastrous effects of tropical cyclones is storm surge. With Metro Manila being a coastal area and the most populous region in the country, with approximately 12.8 million people residing in it, it is of great interest to determine the possibility of generating significant level of storm surge in the country's capital. The necessity to determine the storm surge susceptibility was brought upon by the effect of Typhoon Haiyan on eastern Visayas in 2013, where more than 6,000 people died and resulted to about 2.86 billion dollars' worth of damages. To achieve the objectives, the actual tracks and wind speed of historical typhoon (JMA data since 1951) was mapped for the Philippines. The simulated wind speed map shows that the maximum winds are mostly experienced on the eastern side of the country; with a considerable decrease in wind intensity as the typhoon reaches the western seaboard due to land surface. The Haiyan-strength wind speed is then applied to the actual historical typhoon tracks to determine the hypothetical values of wind speed as a typhoon with Haiyan intensity reached Metro Manila. Results show that, if a typhoon with a Haiyan-like intensity is to traverse tracks like those of Rita 1978, Collen 1992, Sybil 1995, Bebinca 2000 and Xangsane 2000, there is a huge possibility of generating storm surge height of 3.9 to 5.6 m in the western seaboard of Metro Manila, even after considering the diminishing effect of surface friction.

  5. The Climatology of Extreme Surge-Producing Extratropical Cyclones in Observations and Models

    Science.gov (United States)

    Catalano, A. J.; Broccoli, A. J.; Kapnick, S. B.

    2016-12-01

    Extreme coastal storms devastate heavily populated areas around the world by producing powerful winds that can create a large storm surge. Both tropical and extratropical cyclones (ETCs) occur over the northwestern Atlantic Ocean, and the risks associated with ETCs can be just as severe as those associated with tropical storms (e.g. high winds, storm surge). At The Battery in New York City, 17 of the 20 largest storm surge events were a consequence of extratropical cyclones (ETCs), which are more prevalent than tropical cyclones in the northeast region of the United States. Therefore, we analyze the climatology of ETCs that are capable of producing a large storm surge along the northeastern coast of the United States. For a historical analysis, water level data was collected from National Oceanic and Atmospheric Administration (NOAA) tide gauges at three separate locations (Sewell's Pt., VA, The Battery, NY, and Boston, MA). We perform a k-means cluster analysis of sea level pressure from the ECMWF 20th Century Reanalysis dataset (ERA-20c) to explore the natural sets of observed storms with similar characteristics. We then composite cluster results with features of atmospheric circulation to observe the influence of interannual and multidecadal variability such as the North Atlantic Oscillation. Since observational records contain a small number of well-documented ETCs, the capability of a high-resolution coupled climate model to realistically simulate such extreme coastal storms will also be assessed. Global climate models provide a means of simulating a much larger sample of extreme events, allowing for better resolution of the tail of the distribution. We employ a tracking algorithm to identify ETCs in a multi-century simulation under present-day conditions. Quantitative comparisons of cyclolysis, cyclogenesis, and cyclone densities of simulated ETCs and storms from recent history (using reanalysis products) are conducted.

  6. Development and validation of a surgical workload measure: the surgery task load index (SURG-TLX).

    Science.gov (United States)

    Wilson, Mark R; Poolton, Jamie M; Malhotra, Neha; Ngo, Karen; Bright, Elizabeth; Masters, Rich S W

    2011-09-01

    The purpose of the present study was to develop and validate a multidimensional, surgery-specific workload measure (the SURG-TLX), and to determine its utility in providing diagnostic information about the impact of various sources of stress on the perceived demands of trained surgical operators. As a wide range of stressors have been identified for surgeons in the operating room, the current approach of considering stress as a unidimensional construct may not only limit the degree to which underlying mechanisms may be understood but also the degree to which training interventions may be successfully matched to particular sources of stress. The dimensions of the SURG-TLX were based on two current multidimensional workload measures and developed via focus group discussion. The six dimensions were defined as mental demands, physical demands, temporal demands, task complexity, situational stress, and distractions. Thirty novices were trained on the Fundamentals of Laparoscopic Surgery (FLS) peg transfer task and then completed the task under various conditions designed to manipulate the degree and source of stress experienced: task novelty, physical fatigue, time pressure, evaluation apprehension, multitasking, and distraction. The results were supportive of the discriminant sensitivity of the SURG-TLX to different sources of stress. The sub-factors loaded on the relevant stressors as hypothesized, although the evaluation pressure manipulation was not strong enough to cause a significant rise in situational stress. The present study provides support for the validity of the SURG-TLX instrument and also highlights the importance of considering how different stressors may load surgeons. Implications for categorizing the difficulty of certain procedures, the implementation of new technology in the operating room (man-machine interface issues), and the targeting of stress training strategies to the sources of demand are discussed. Modifications to the scale to enhance

  7. Performance and Adaptive Surge-Preventing Acceleration Prediction of a Turboshaft Engine under Inlet Flow Distortion

    OpenAIRE

    Cao Dalu; Tang Hailong; Chen Min

    2017-01-01

    The intention of this paper is to research the inlet flow distortion influence on overall performance of turboshaft engine and put forward a method called Distortion Factor Item (DFI) to improve the fuel supply plan for surge-preventing acceleration when turboshaft engine suddenly encounters inlet flow distortion. Based on the parallel compressor theory, steady-state and transition-state numerical simulation model of turboshaft engine with sub-compressor model were established for researching...

  8. Ovarian Follicular Dynamics During the Luteinizing Hormone Surge in the Bottlenose Dolphin (Tursiops truncatus)

    OpenAIRE

    Muraco, Holley; Clough, Pat; Teets, Valerie; Arn, Dennis; Muraco, Mike

    2010-01-01

    Characterizing the relationship between ovarian follicular dynamics and the luteinizing hormone (LH) surge in the bottlenose dolphin (Tursiops truncatus) requires detailed daily monitoring due to the transitory nature of LH and ovulation. Utilizing conditioned dolphins and non-invasive sampling techniques, such as urine collection and trans-abdominal ultrasound exams, provides the means to accurately monitor these fleeting processes. Urine samples and ultrasound exams used in this study were ...

  9. Genital Sensory Stimulation Shifts Estradiol Intraoviductal Signaling from Nongenomic to Genomic Pathways, Independently from Prolactin Surges

    Directory of Open Access Journals (Sweden)

    C PEÑARROJA-MATUTAN0

    2007-01-01

    Full Text Available Estradiol (E2 accelerates oviductal egg transport through nongenomic pathways involving oviductal protein phosphorylation in non-mated rats, and through genomic pathways in mated rats. Here we investigated the ability of cervico-vaginal stimulation (CVS to switch the mode of action of E2 in the absence of other male-associated components. Pro-estrous rats were subjected to CVS with a glass rod and 12 hours later were injected subcutaneously with E2 and intrabursally with the RNA synthesis inhibitor Actinomycin D or the protein phosphorylation inhibitor H-89. The number of eggs in the oviduct, assessed 24 h later, showed that Actinomycin D, but not H-89 blocked the E2-induced egg transport acceleration. This clearly indicates that CVS alone, without other mating-associated signals, is able to shift E2 signaling from nongenomic to genomic pathways. Since mating and CVS activate a neuroendocrine reflex that causes iterative prolactin (PRL surges, the involvement of PRL pathway in this phenomenon was evaluated. Prolactin receptor mRNA and protein expression in the rat oviduct was demonstrated by RT-PCR and Western blot, but their levels were not different on day 2 of the cycle (C2 or pregnancy (P2. Activated ST AT 5a/b (phosphorylated was detected by Western blot on P2 in the ovary, but not in the oviduct, showing that mating does not stimulate this PRL signalling pathway in the oviduct. Other rats subjected to CVS in the evening of pro-estrus were treated with bromoergocriptine to suppress PRL surges. In these rats, H-89 did not block the E2-induced acceleration of egg transport suggesting that PRL surges are not essential to shift E2 signaling pathways in the oviduct. We conclude that CVS is one of the components of mating that shifts E2 signaling in the oviduct from nongenomic to genomic pathways, and this effect is independent of PRL surges elicited by mating

  10. Parameters Calculation of ZnO Surge Arrester Models by Genetic Algorithms

    Directory of Open Access Journals (Sweden)

    A. Bayadi

    2006-09-01

    Full Text Available This paper proposes to provide a new technique based on the genetic algorithm to obtain the best possible series of values of the parameters of the ZnO surge arresters models. The validity of the predicted parameters is then checked by comparing the results predicted with the experimental results available in the literature. Using the ATP-EMTP package an application of the arrester model on network system studies is presented and discussed.

  11. Simulation and Validation of a Storm Surge in Bays and Estuaries With Complex Coastline Geometry

    Science.gov (United States)

    Dukhovskoy, D. S.; Morey, S. L.

    2008-12-01

    Simulation of nearshore ocean dynamics in a region with a complex coastline, commonly found along bays and estuaries, has been a challenging task for modelers. Over the last decade, unstructured grid models based on finite-element and finite-volume methods have been gaining popularity within the ocean modeling community. Application of this type of model facilitates accurate representation of the nearshore processes in model domains with bays, estuaries, and river channels. This study demonstrates the utility of applying an unstructured grid model for simulation and analysis of a storm surge in such a region. A high-resolution storm surge model of Apalachee Bay in the northeastern Gulf of Mexico is developed using an unstructured grid Finite-Volume Coastal Ocean Model (FVCOM) with wetting and drying capabilities. The model is applied to the case of Hurricane Dennis (July 2005). This storm caused underpredicted severe flooding of the Apalachee Bay coastal area and communities located inland up rivers that has yet to be adequately explained. Accurate resolution of the complicated geometry of the coastal region and waterways in the model reveals substantial spatial variability in the amplitude and timing of the maximum water level and processes responsible for the unanticipated high storm tide in the area. In this study, a methodology of validating a storm surge simulations using high-water marks is illustrated. Model experiments suggest that excessive flooding in the coastal zone during Dennis was caused by additive effects of coincident high tides, wave setup, and a propagating shelf wave that added to the locally wind generated surge.

  12. Storm surge modeling of Superstorm Sandy in the New York City Metropolitan area

    Science.gov (United States)

    Benimoff, A. I.; Blanton, B. O.; Dzedzits, E.; Fritz, W. J.; Kress, M.; Muzio, P.; Sela, L.

    2013-12-01

    Even though the New York/New Jersey area does not lie within the typical 'hurricane belt', recent events and the historical record indicate that large infrequent tropical storms have had direct hits on the region, with impacts being amplified due to the nearly right angle bend in the coastline. The recent plan unveiled by New York City's Mayor Bloomberg lays out mitigation strategies to protect the region's communities, infrastructure, and assets from future storms, and numerical simulation of storm surge and wave hazards driven by potential hurricanes plays a central role in developing and evaluating these strategies. To assist in local planning, recovery, and decision-making, we have used the tide, storm surge, and wind wave model ADCIRC+SWAN to simulate storm surge in one of the most populated areas of the United States: the New York City (NYC) metropolitan area. We have generated a new high-resolution triangular finite-element model grid for the region from recent USGS data as well as recent city topographic maps at 2-foot (0.6m) contour intervals, nautical charts, and details of shipping channels. Our hindcast simulations are compared against Superstorm Sandy. We used the City University of New York High Performance Computing Center's Cray XE6tm at the College of Staten Island for these simulations. Hindcasting and analysis of the Superstorm Sandy storm surge and waves indicates that our simulations produce a reasonable representation of actual events. The grid will be used in an ADCIRC-based forecasting system implementation for the region.

  13. Security, Violent Events, and Anticipated Surge Capabilities of Emergency Departments in Washington State

    OpenAIRE

    Weyand, Jonathan S.; Junck, Emily; Kang, Christopher S.; Heiner, Jason D.

    2017-01-01

    Background: Over the past 15 years, violent threats and acts against hospital patients, staff, and providers have increased and escalated. The leading area for violence is the emergency department given its 24/7 operations, its role in patient care, admissions gateway, and the center for influxes during acute surge events. Objectives: This investigation had three objectives: to assess the current security of Washington State EDs, to estimate the prevalence of and respon...

  14. Human survival in volcanic eruptions: Thermal injuries in pyroclastic surges, their causes, prognosis and emergency management.

    Science.gov (United States)

    Baxter, Peter J; Jenkins, Susanna; Seswandhana, Rosadi; Komorowski, Jean-Christophe; Dunn, Ken; Purser, David; Voight, Barry; Shelley, Ian

    2017-08-01

    This study of burns patients from two eruptions of Merapi volcano, Java, in 1994 and 2010, is the first detailed analysis to be reported of thermal injuries in a large series of hospitalised victims of pyroclastic surges, one of the most devastating phenomena in explosive eruptions. Emergency planners in volcanic crises in populated areas have to integrate the health sector into disaster management and be aware of the nature of the surge impacts and the types of burns victims to be expected in a worst scenario, potentially in numbers and in severity that would overwhelm normal treatment facilities. In our series, 106 patients from the two eruptions were treated in the same major hospital in Yogyakarta and a third of these survived. Seventy-eight per cent were admitted with over 40% TBSA (total body surface area) burns and around 80% of patients were suspected of having at least some degree of inhalation injury as well. Thirty five patients suffered over 80% TBSA burns and only one of these survived. Crucially, 45% of patients were in the 40-79% TBSA range, with most suspected of suffering from inhalation injury, for whom survival was most dependent on the hospital treatment they received. After reviewing the evidence from recent major eruptions and outlining the thermal hazards of surges, we relate the type and severity of the injuries of these patients to the temperatures and dynamics of the pyroclastic surges, as derived from the environmental impacts and associated eruption processes evaluated in our field surveys and interviews conducted by our multi-disciplinary team. Effective warnings, adequate evacuation measures, and political will are all essential in volcanic crises in populated areas to prevent future catastrophes on this scale. Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.

  15. Surge-like Oscillations above Sunspot Light Bridges Driven by Magnetoacoustic Shocks

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jingwen; Tian, Hui; He, Jiansen; Wang, Linghua, E-mail: huitian@pku.edu.cn [School of Earth and Space Sciences, Peking University, 100871 Beijing (China)

    2017-03-20

    High-resolution observations of the solar chromosphere and transition region often reveal surge-like oscillatory activities above sunspot light bridges (LBs). These oscillations are often interpreted as intermittent plasma jets produced by quasi-periodic magnetic reconnection. We have analyzed the oscillations above an LB in a sunspot using data taken by the Interface Region Imaging Spectrograph . The chromospheric 2796 Å images show surge-like activities above the entire LB at any time, forming an oscillating wall. Within the wall we often see that the core of the Mg ii k 2796.35 Å line first experiences a large blueshift, and then gradually decreases to zero shift before increasing to a redshift of comparable magnitude. Such a behavior suggests that the oscillations are highly nonlinear and likely related to shocks. In the 1400 Å passband, which samples emission mainly from the Si iv ion, the most prominent feature is a bright oscillatory front ahead of the surges. We find a positive correlation between the acceleration and maximum velocity of the moving front, which is consistent with numerical simulations of upward propagating slow-mode shock waves. The Si iv 1402.77 Å line profile is generally enhanced and broadened in the bright front, which might be caused by turbulence generated through compression or by the shocks. These results, together with the fact that the oscillation period stays almost unchanged over a long duration, lead us to propose that the surge-like oscillations above LBs are caused by shocked p-mode waves leaked from the underlying photosphere.

  16. Increased intracranial volume in Parkinson's disease

    DEFF Research Database (Denmark)

    Krabbe, Katja; Karlsborg, Merete; Hansen, Andreas

    2005-01-01

    Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that can be difficult to diagnose and distinguish from each other. STUDY AIMS AND METHODS: Patients with PD and MSA and controls were studied with magnetic resonance imaging (MRI) using tissue segmentation...

  17. Bladder dysfunction in advanced Parkinson's disease

    DEFF Research Database (Denmark)

    Winge, Kristian; Nielsen, Kurt K

    2012-01-01

    Parkinson's disease (PD) patients often have lower urinary tract symptoms. Seventy-four percent of patients with early-to-moderate disease report more than one bladder disturbance symptom. Severe bladder symptoms are reported in 27-39% of PD patients. The aim of this study was to evaluate...

  18. Biomarker Research in Parkinson's Disease Using Metabolite Profiling

    DEFF Research Database (Denmark)

    Havelund, Jesper F; Heegaard, Niels H H; Færgeman, Nils J K

    2017-01-01

    Biomarker research in Parkinson's disease (PD) has long been dominated by measuring dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do not allow early detection, precise prognosis or monitoring of disease progression. Moreover, PD is now considered a multifa......) and purine metabolism (uric acid) are also altered in most metabolite profiling studies in PD......., the potential as a biomarker and the significance of understanding the pathophysiology of PD. Many of the studies report alterations in alanine, branched-chain amino acids and fatty acid metabolism, all pointing to mitochondrial dysfunction in PD. Aromatic amino acids (phenylalanine, tyrosine, tryptophan...

  19. Social cognition of indirect speech: Evidence from Parkinson's Disease.

    Science.gov (United States)

    McNamara, Patrick; Holtgraves, Thomas; Durso, Raymon; Harris, Erica

    2010-03-01

    We examined potential neurocognitive mechanisms of indirect speech in support of face management in 28 patients with Parkinson's disease (PD) and 32 elderly controls with chronic disease. In experiment 1, we demonstrated automatic activation of indirect meanings of particularized implicatures in controls but not in PD patients. Failure to automatically engage comprehension of indirect meanings of indirect speech acts in PD patients was correlated with a measure of prefrontal dysfunction. In experiment 2, we showed that while PD patients and controls offered similar interpretations of indirect speech acts, PD participants were overly confident in their interpretations and unaware of errors of interpretation. Efficient reputational adjustment mechanisms apparently require intact striatal-prefrontal networks.

  20. A hybrid DEM-SPH model for deformable landslide and its generated surge waves

    Science.gov (United States)

    Tan, Hai; Chen, Shenghong

    2017-10-01

    Reservoir bank landslide and its generated surge waves are catastrophic hazards which may give rise to additional sedimentation, destroy hydraulic structures, and even cause fatalities. Since this process is very complex involving landslide impact, wave generation and propagation, it cannot be well captured with traditional numerical approaches. In this paper, a hybrid DEM-SPH model is presented to simulate landslide and to reproduce its generated surge waves. This model consists of discrete element method (DEM) for solid phase and smoothed particle hydrodynamics (SPH) for fluid phase as well as drag force and buoyancy for solid-fluid interaction. Meanwhile, the δ-SPH algorithm is employed to eliminate spurious numerical noise on the pressure field. Submarine rigid block slide is numerically tested to validate the proposed hybrid model, and the computed wave profiles exhibit a satisfactory agreement with the experiment. The hybrid model is further extended towards the submarine granular deformable slide which generates smaller and less violent surge waves. Kinetic and potential energy of both solid and fluid particle system are extracted to throw a light upon the process of landslide water interaction from an energy perspective. Finally, a sensitivity analysis on particle friction coefficient indicates that the lubrication of the solid particles is another important effect influencing the underwater landslide movement in addition to the drag effect.