Sample records for diminuta gene arrangements

  1. Complete Sequence of the mitochondrial genome of the tapeworm Hymenolepis diminuta: Gene arrangements indicate that platyhelminths are eutrochozoans

    von Nickisch-Rosenegk, Markus; Brown, Wesley M.; Boore, Jeffrey L.


    Using ''long-PCR'' we have amplified in overlapping fragments the complete mitochondrial genome of the tapeworm Hymenolepis diminuta (Platyhelminthes: Cestoda) and determined its 13,900 nucleotide sequence. The gene content is the same as that typically found for animal mitochondrial DNA (mtDNA) except that atp8 appears to be lacking, a condition found previously for several other animals. Despite the small size of this mtDNA, there are two large non-coding regions, one of which contains 13 repeats of a 31 nucleotide sequence and a potential stem-loop structure of 25 base pairs with an 11-member loop. Large potential secondary structures are identified also for the non-coding regions of two other cestode mtDNAs. Comparison of the mitochondrial gene arrangement of H. diminuta with those previously published supports a phylogenetic position of flatworms as members of the Eutrochozoa, rather than being basal to either a clade of protostomes or a clade of coelomates.

  2. Hymenolepis diminuta (Cestoda) induces changes in expression of select genes of Tribolium confusum (Coleoptera).

    Hitchen, Steven J; Shostak, Allen W; Belosevic, Miodrag


    The flour beetle Tribolium confusum is a common experimental intermediate host for the tapeworm Hymenolepis diminuta, but while many aspects of their host-parasite interactions have been determined to have genetic basis, the genes involved have not been identified. In this paper, we report on the expression of several predicted metabolic and defense-related genes using quantitative polymerase chain reaction 2 weeks after initial infection of the beetle. The expression of heat shock protein 68, a predicted sugar transporter, a pheromone binding protein, and endoglin were up-regulated in infected beetles. The expression of thaumatin-like protein and prophenoloxidase 2/3 was down-regulated in infected beetles, while the mRNA levels of Toll-like receptor 3, Toll-like receptor 4, and lysozyme 4 were not affected by infection with H. diminuta.

  3. Pleuritis due to Brevundimonas diminuta in a previously healthy man.

    Lu, Binghuai; Shi, Yanli; Zhu, Fengxia; Xu, Xiaolin


    Brevundimonas diminuta is rarely associated with invasive infections. We report the case of a previously healthy young man with pleural effusion, in which B. diminuta was recovered but incorrectly identified as Kingella kingae when it was freshly isolated. Consequently, the misidentification resulted in initial treatment failure. The correct identification was achieved through further incubation, sequencing of the 16S rRNA gene and MS.

  4. Differential diagnosis and molecular characterization of Hymenolepis nana and Hymenolepis diminuta (Cestoda: Cyclophyllidea: Hymenolepididae) based on nuclear rDNA ITS2 gene marker.

    Sharma, Sunil; Lyngdoh, Damanbha; Roy, Bishnupada; Tandon, Veena


    Given the widespread distribution and medical implication of members of the genus Hymenolepis, specific identification of the aetiological agent becomes imperative. For precise diagnosis of the species, molecular techniques such as PCR and RFLP of the nuclear ribosomal internal transcribed spacer 2 (rDNA-ITS2) gene marker were carried out. The results showed distinct restriction patterns for both Hymenolepis nana and Hymenolepis diminuta when digested with either of the enzymes RsaI, HaeIII or HhaI. The annotated rDNA-ITS2 sequences from the two species revealed differences in the length; the folded secondary structure also depicted clear demarcation between the two species with variations in length of the helices, pyrimidine-pyrimidine mismatches and sites where motifs occur. In phylogenetic analysis of the evolutionary relationship between the two species as well as with other members of the family Hymenolepididae, the species causing human hymenolepiasis were found to be distantly related as they diverged independently from the ancestral lineage.

  5. The chromosomal arrangement of six soybean leghemoglobin genes

    Bojsen, Kirsten; Abildsten, Dorte; Jensen, Erik Ø


    Clones containing six leghemoglobin (Lb) genes have been isolated from two genomic libraries of soybean. They encompass two independent DNA regions: a 40-kb region containing four genes in the order 5' Lba-Lbc(1)-[unk]Lb-Lbc(3) 3' with the same transcriptional polarity, and another 40-kb region...... containing two genes in the order 5' Lbc(4)-Lbc(2) 3' with the same polarity. The order in which the Lb genes are arranged in the soybean genome imply that they are activated in the opposite order to which they are arranged on the chromosome. There is a close similarity between corresponding DNA regions...... differs from that of the Lb genes. The existence of two very similar Lb gene clusters in soybean suggest that soybean may have evolved from an ancestral form by genome duplication. Udgivelsesdato: 1983-null...

  6. Arabidopsis PAI gene arrangements, cytosine methylation and expression.

    Melquist, S.; Luff, B; Bender, J.


    Previous analysis of the PAI tryptophan biosynthetic gene family in Arabidopsis thaliana revealed that the Wassilewskija (WS) ecotype has four PAI genes at three unlinked sites: a tail-to-tail inverted repeat at one locus (PAI1-PAI4) plus singlet genes at two other loci (PAI2 and PAI3). The four WS PAI genes are densely cytosine methylated over their regions of DNA identity. In contrast, the Columbia (Col) ecotype has three singlet PAI genes at the analogous loci (PAI1, PAI2, and PAI3) and no...

  7. 5S rRNA gene arrangements in protists: a case of nonadaptive evolution.

    Drouin, Guy; Tsang, Corey


    Given their high copy number and high level of expression, one might expect that both the sequence and organization of eukaryotic ribosomal RNA genes would be conserved during evolution. Although the organization of 18S, 5.8S and 28S ribosomal RNA genes is indeed relatively well conserved, that of 5S rRNA genes is much more variable. Here, we review the different types of 5S rRNA gene arrangements which have been observed in protists. This includes linkages to the other ribosomal RNA genes as well as linkages to ubiquitin, splice-leader, snRNA and tRNA genes. Mapping these linkages to independently derived phylogenies shows that these diverse linkages have repeatedly been gained and lost during evolution. This argues against such linkages being the primitive condition not only in protists but also in other eukaryote species. Because the only characteristic the diverse genes with which 5S rRNA genes are found linked with is that they are tandemly repeated, these arrangements are unlikely to provide any selective advantage. Rather, the observed high variability in 5S rRNA genes arrangements is likely the result of the fact that 5S rRNA genes contain internal promoters, that these genes are often transposed by diverse recombination mechanisms and that these new gene arrangements are rapidly homogenized by unequal crossingovers and/or by gene conversions events in species with short generation times and frequent founder events.

  8. Quantitative real-time PCR and fluorescence in situ hybridization approaches for enumerating Brevundimonas diminuta in drinking water.

    Donofrio, Robert S; Bestervelt, Lorelle L; Saha, Ratul; Bagley, Susan T


    Brevundimonas diminuta is a small Gram-negative bacterium used for validation of membranes and filters used in the pharmaceutical and drinking water treatment industries. Current assays are time consuming, nonselective, and may be subject to interference by competing indigenous microorganisms. The focus of this study is to develop rapid and specific enumeration methodologies for B. diminuta. Quantitative real-time polymerase chain reaction (qPCR) and fluorescence in situ hybridization (FISH) assays were developed based on the gyrB (1,166 bp) and rpoD (829 bp) gene sequences of B. diminuta ATCC 19146. Species-specific primers and probes were designed, and a 100-200 bp segment of each gene was targeted in the qPCR studies. For both the qPCR and FISH assays, an internal 25 bp sequence was selected for use as a TaqMan probe (labeled with 6-FAM and a Black Hole Quencher). Probe specificity studies, conducted against Gram-negative and Gram-positive reference strains as well as environmental strains, revealed high specificity of the primer/probe pairs to B. diminuta. Sensitivities of the qPCR reactions using purified genomic DNA from B. diminuta were determined to be 0.89 pg for rpoD and 8.9 pg for gyrB. The feasibility of using whole-cell B. diminuta suspensions directly with the rpoD qPCR protocol was also evaluated. The greatest sensitivity observed for B. diminuta was 1 x 10(3) colony forming units (CFU) per mL when tryptic soy broth was used as the growth medium. When compared with direct microscopic enumeration using a 5' 6-FAM FISH probe, traditional plating methods showed significant underestimation of B. diminuta concentration (P = 0.01) when this organism was cultivated in saline lactose broth. The results of this investigation demonstrate that qPCR and FISH are effective methods for rapid (alternatives to plating when validating drinking water filtration systems.

  9. Chloroplast gene arrangement variation within a closely related group of green algae (Trebouxiophyceae, Chlorophyta).

    Letsch, Molly R; Lewis, Louise A


    The 22 published chloroplast genomes of green algae, representing sparse taxonomic sampling of diverse lineages that span over one billion years of evolution, each possess a unique gene arrangement. In contrast, many of the >190 published embryophyte (land plant) chloroplast genomes have relatively conserved architectures. To determine the phylogenetic depth at which chloroplast gene rearrangements occur in green algae, a 1.5-4 kb segment of the chloroplast genome was compared across nine species in three closely related genera of Trebouxiophyceae (Chlorophyta). In total, four distinct gene arrangements were obtained for the three genera Elliptochloris, Hemichloris, and Coccomyxa. In Elliptochloris, three distinct chloroplast gene arrangements were detected, one of which is shared with members of its sister genus Hemichloris. Both species of Coccomyxa examined share the fourth arrangement of this genome region, one characterized by very long spacers. Next, the order of genes found in this segment of the chloroplast genome was compared across green algae and land plants. As taxonomic ranks are not equivalent among different groups of organisms, the maximum molecular divergence among taxa sharing a common gene arrangement in this genome segment was compared. Well-supported clades possessing a single gene order had similar phylogenetic depth in green algae and embryophytes. When the dominant gene order of this chloroplast segment in embryophytes was assumed to be ancestral for land plants, the maximum molecular divergence was found to be over two times greater in embryophytes than in trebouxiophyte green algae. This study greatly expands information about chloroplast genome variation in green algae, is the first to demonstrate such variation among congeneric green algae, and further illustrates the fluidity of green algal chloroplast genome architecture in comparison to that of many embryophytes.

  10. Extensive mitochondrial gene arrangements in coleoid Cephalopoda and their phylogenetic implications.

    Akasaki, Tetsuya; Nikaido, Masato; Tsuchiya, Kotaro; Segawa, Susumu; Hasegawa, Masami; Okada, Norihiro


    We determined the complete mitochondrial genomes of five cephalopods of the Subclass Coleoidea (Suborder Oegopsida: Watasenia scintillans, Todarodes pacificus, Suborder Myopsida: Sepioteuthis lessoniana, Order Sepiida: Sepia officinalis, and Order Octopoda: Octopus ocellatus) and used them to infer phylogenetic relationships. In our Maximum Likelihood (ML) tree, sepiids (cuttlefish) are at the most basal position of all decapodiformes, and oegopsids and myopsids form a monophyletic clade, thus supporting the traditional classification of the Order Teuthida. We detected extensive gene rearrangements in the mitochondrial genomes of broad cephalopod groups. It is likely that the arrangements of mitochondrial genes in Oegopsida and Sepiida were derived from those of Octopoda, which is thought to be the ancestral order, by entire gene duplication and random gene loss. Oegopsida in particular has undergone long-range gene duplications. We also found that the mitochondrial gene arrangement of Sepioteuthis lessoniana differs from that of Loligo bleekeri, although they belong to the same family. Analysis of both the phylogenetic tree and mitochondrial gene rearrangements of coleoid Cephalopoda suggests that each mitochondrial gene arrangement was acquired after the divergence of each lineage.

  11. Partial mitochondrial gene arrangements support a close relationship between Tardigrada and Arthropoda.

    Ryu, Shi Hyun; Lee, Ji Min; Jang, Kuem-Hee; Choi, Eun Hwa; Park, Shin Ju; Chang, Cheon Young; Kim, Won; Hwang, Ui Wook


    Regions (about 3.7-3.8 kb) of the mitochondrial genomes (rrnL-cox1) of two tardigrades, a heterotardigrade, Batillipes pennaki, and a eutardigrade, Pseudobiotus spinifer, were sequenced and characterized. The gene order in Batillipes was rrnL-V-rrnS-Q-I-M-nad2-W-C-Y-cox1, and in Pseudobiotus it was rrnL-V-rrnS-Q-M-nad2-W-C-Y-cox1. With the exception of the trnI gene, the two tardigrade regions have the same gene content and order. Their gene orders are strikingly similar to that of the chelicerate Limulus polyphemus (rrnL-V-rrnS-CR-I-Q-M-nad2-W-C-Y-cox1), which is considered to be ancestral for arthropods. Although the tardigrades do not have a distinct control region (CR) within this segment, the trnI gene in Pseudobiotus is located between rrnL-trnL1 and trnL2-nad1, and the trnI gene in Batillipes is located between trnQ and trnM. In addition, the 106-bp region between trnQ and trnM in Batillipes not only contains two plausible trnI genes with opposite orientations, but also exhibits some CR-like characteristics. The mitochondrial gene arrangements of 183 other protostomes were compared. 60 (52.2%) of the 115 arthropods examined have the M-nad2-W-C-Y-cox1 arrangement, and 88 (76.5%) the M-nad2-W arrangement, as found in the tardigrades. In contrast, no such arrangement was seen in the 70 non-arthropod protostomes studied. These are the first non-sequence molecular data that support the close relationship of tardigrades and arthropods.

  12. Hymenolepis diminuta infection in a young boy from rural part of Northern India

    Pratibha Mane


    Full Text Available Hymenolepis diminuta (H. diminuta is primarily a parasite of rats and mice. Humans are infected by eating meal contaminated with these arthropods. This infection is not seen commonly in Indian population. We present here a case report of infection with H. diminuta in a young boy from a rural area of the North India.

  13. Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome.


    A 23-kb fragment of the Streptomyces coelicolor chromosome spanning the dnaA region has been isolated as a cosmid clone. Nucleotide sequence analysis of a 5-kb portion shows that the genes for the RNase P protein (rnpA), ribosomal protein L34 (rpmH), the replication initiator protein (dnaA), and the beta subunit of DNA polymerase III (dnaN) are present in the highly conserved gene arrangement found in all eubacterial genomes studied so far. The dnaA-dnaN intergenic region is approximately 1 k...

  14. The Arabidopsis Adh gene exhibits diverse nucleosome arrangements within a small DNase I-sensitive domain.

    Vega-Palas, M A; Ferl, R J


    The alcohol dehydrogenase (Adh) gene from Arabidopsis shows enhanced sensitivity to DNase I in cells that express the gene. This generalized sensitivity to DNase I is demarcated by position -500 on the 5' side and the end of the mRNA on the 3' side. Thus, the gene defined as the promoter and mRNA coding region corresponds very closely in size with the gene defined as a nuclease-sensitive domain. This is a remarkably close correspondence between a sensitive domain and a eukaryotic transcriptional unit, because previously reported DNase I-sensitive domains include large regions of DNA that are not transcribed. Nucleosomes are present in the coding region of the Adh gene when it is expressed, indicating that the transcriptional elongation process causes nucleosome disruption rather than release of nucleosomes from the coding region. In addition, the regulatory region contains a loosely positioned nucleosome that is separated from adjacent nucleosomes by internucleosomic DNA segments longer than the average linker DNA in bulk chromatin. This specific array of nucleosomes coexists with bound transcription factors that could contribute to the organization of the nucleosome arrangement. These results enhance our understanding of the complex interactions among DNA, nucleosomes, and transcription factors during gene expression in plants. PMID:8535143

  15. Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family.

    Dassa, Bareket; London, Nir; Stoddard, Barry L; Schueler-Furman, Ora; Pietrokovski, Shmuel


    Inteins are genetic elements, inserted in-frame into protein-coding genes, whose products catalyze their removal from the protein precursor via a protein-splicing reaction. Intein domains can be split into two fragments and still ligate their flanks by a trans-protein-splicing reaction. A bioinformatic analysis of environmental metagenomic data revealed 26 different loci with a novel genomic arrangement. In each locus, a conserved enzyme coding region is broken in two by a split intein, with a free-standing endonuclease gene inserted in between. Eight types of DNA synthesis and repair enzymes have this 'fractured' organization. The new types of naturally split-inteins were analyzed in comparison to known split-inteins. Some loci include apparent gene control elements brought in with the endonuclease gene. A newly predicted homing endonuclease family, related to very-short patch repair (Vsr) endonucleases, was found in half of the loci. These putative homing endonucleases also appear in group-I introns, and as stand-alone inserts in the absence of surrounding intervening sequences. The new fractured genes organization appears to be present mainly in phage, shows how endonucleases can integrate into inteins, and may represent a missing link in the evolution of gene breaking in general, and in the creation of split-inteins in particular.

  16. Gene arrangement convergence, diverse intron content, and genetic code modifications in mitochondrial genomes of sphaeropleales (chlorophyta).

    Fučíková, Karolina; Lewis, Paul O; González-Halphen, Diego; Lewis, Louise A


    The majority of our knowledge about mitochondrial genomes of Viridiplantae comes from land plants, but much less is known about their green algal relatives. In the green algal order Sphaeropleales (Chlorophyta), only one representative mitochondrial genome is currently available-that of Acutodesmus obliquus. Our study adds nine completely sequenced and three partially sequenced mitochondrial genomes spanning the phylogenetic diversity of Sphaeropleales. We show not only a size range of 25-53 kb and variation in intron content (0-11) and gene order but also conservation of 13 core respiratory genes and fragmented ribosomal RNA genes. We also report an unusual case of gene arrangement convergence in Neochloris aquatica, where the two rns fragments were secondarily placed in close proximity. Finally, we report the unprecedented usage of UCG as stop codon in Pseudomuriella schumacherensis. In addition, phylogenetic analyses of the mitochondrial protein-coding genes yield a fully resolved, well-supported phylogeny, showing promise for addressing systematic challenges in green algae. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  17. The Rhodomonas salina mitochondrial genome: bacteria-like operons, compact gene arrangement and complex repeat region.

    Hauth, Amy M; Maier, Uwe G; Lang, B Franz; Burger, Gertraud


    To gain insight into the mitochondrial genome structure and gene content of a putatively ancestral group of eukaryotes, the cryptophytes, we sequenced the complete mitochondrial DNA of Rhodomonas salina. The 48 063 bp circular-mapping molecule codes for 2 rRNAs, 27 tRNAs and 40 proteins including 23 components of oxidative phosphorylation, 15 ribosomal proteins and two subunits of tat translocase. One potential protein (ORF161) is without assigned function. Only two introns occur in the genome; both are present within cox1 belong to group II and contain RT open reading frames. Primitive genome features include bacteria-like rRNAs and tRNAs, ribosomal protein genes organized in large clusters resembling bacterial operons and the presence of the otherwise rare genes such as rps1 and tatA. The highly compact gene organization contrasts with the presence of a 4.7 kb long, repeat-containing intergenic region. Repeat motifs approximately 40-700 bp long occur up to 31 times, forming a complex repeat structure. Tandem repeats are the major arrangement but the region also includes a large, approximately 3 kb, inverted repeat and several potentially stable approximately 40-80 bp long hairpin structures. We provide evidence that the large repeat region is involved in replication and transcription initiation, predict a promoter motif that occurs in three locations and discuss two likely scenarios of how this highly structured repeat region might have evolved.

  18. Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome.

    Calcutt, M J; Schmidt, F J


    A 23-kb fragment of the Streptomyces coelicolor chromosome spanning the dnaA region has been isolated as a cosmid clone. Nucleotide sequence analysis of a 5-kb portion shows that the genes for the RNase P protein (rnpA), ribosomal protein L34 (rpmH), the replication initiator protein (dnaA), and the beta subunit of DNA polymerase III (dnaN) are present in the highly conserved gene arrangement found in all eubacterial genomes studied so far. The dnaA-dnaN intergenic region is approximately 1 kb and contains a cluster of at least 12 DnaA boxes with a consensus sequence of TTGTCCACA matching the consensus DnaA box in the phylogenetically related Micrococcus luteus. Two DnaA boxes precede the dnaA sequence. We propose that the chromosomal origin (oriC) of S. coelicolor lies between dnaA and dnaN. In related work, J. Zakrzewska-Czerwinska and H. Schrempf (J. Bacteriol. 174:2688-2693, 1992) have identified the homologous sequence from the closely-related Streptomyces lividans as capable of self-replication. PMID:1577691

  19. The mitochondrial genome sequence of a deep-sea, hydrothermal vent limpet, Lepetodrilus nux, presents a novel vetigastropod gene arrangement.

    Nakajima, Yuichi; Shinzato, Chuya; Khalturina, Mariia; Nakamura, Masako; Watanabe, Hiromi; Satoh, Noriyuki; Mitarai, Satoshi


    While mitochondrial (mt) genomes are used extensively for comparative and evolutionary genomics, few mt genomes of deep-sea species, including hydrothermal vent species, have been determined. The Genus Lepetodrilus is a major deep-sea gastropod taxon that occurs in various deep-sea ecosystems. Using next-generation sequencing, we determined nearly the complete mitochondrial genome sequence of Lepetodrilus nux, which inhabits hydrothermal vents in the Okinawa Trough. The total length of the mitochondrial genome is 16,353bp, excluding the repeat region. It contains 13 protein-coding genes, 22 tRNA genes, two rRNA genes, and a control region, typical of most metazoan genomes. Compared with other vetigastropod mt genome sequences, L. nux employs a novel mt gene arrangement. Other novel arrangements have been identified in the vetigastropod, Fissurella volcano, and in Chrysomallon squamiferum, a neomphaline gastropod; however, all three gene arrangements are different, and Bayesian inference suggests that each lineage diverged independently. Our findings suggest that vetigastropod mt gene arrangements are more diverse than previously realized.

  20. Interactions of the cysticercoids of Hymenolepis diminuta and raillietina cesticillus in their intermediate host, Tribolium confusum.

    Gordon, D M; Whitfield, P J


    This study was based on the experimental exposure of beetles to homologous and heterologous infections of Hymenolepis diminuta and Raillietina cesticillus. The results demonstrated that, for both species over the range of parasite densities employed, the presence of a primary infection had no effect on the establishment success of an homologous challenge infection. The establishment success of R. cesticillus cysticercoids was not affected by the presence of an H. diminuta infection. The existence of an R. cesticillus infection, however, severely reduced the establishment success of an H. diminuta infection. The reduction in H. diminuta establishment was greatest in R. cesticillus infections less than 10 days old. The plausibility of some of the mechanisms that are potentially responsible for the reduction in H. diminuta establishment success is discussed, as is the possible ecological significance of these results.

  1. The dynamics of infection of Tribolium confusum by Hymenolepis diminuta: the influence of infective-stage density and spatial distribution.

    Keymer, A E; Anderson, R M


    The mean parasite burden of a population of Tribolium confusum is shown to rise to a plateau as the exposure density of infective eggs of Hymenolepis diminuta increases. The level of this plateau is shown to be dependent on the nutritional status of the host population, being depressed from approximately 18 cysticeroids/beetle in hosts which have been starved prior to experimentation, to approximately 2 cysticercoids/beetle in satiated hosts. A simple model is used to describe the shape of this infection functional response in terms of the predator-prey interaction between hosts (T. confusum) and parasite infective stages (H. diminuta eggs). The distribution of successful infections/host is shown to be over-dispersed, even when hosts are exposed to infective stages arranged in a uniform spatial pattern. The over-dispersion of parasite numbers/host is shown to become more severe as the spatial pattern of infective stages changes from under-dispersed, through random, to over-dispersed. Experimental results are discussed in relation to the dynamics of parasite-host interactions, in which infection takes place by host ingestion of a free-living infective stage.

  2. Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells.

    Harnicarová, Andrea; Kozubek, Stanislav; Pacherník, Jirí; Krejci, Jana; Bártová, Eva


    Using sequential RNA-DNA fluorescence in situ hybridization, the nuclear arrangement of both the active and inactive c-myc gene as well as its transcription was investigated in colon cancer HT-29 cells induced to differentiate into enterocytes. Cytogenetic studies revealed the presence of two chromosomes 8 in HT-29 cells, of which the one containing c-myc gene amplicons was substantially larger and easily distinguished from the normal chromosome. This observation enabled detection of both activity and nuclear localization of c-myc genes in single cells and in individual chromosome territories. Similar transcriptional activity of the c-myc gene was observed in both the normal and derivative chromosome 8 territories showing no influence of the amplification on the c-myc gene expression. Our experiments demonstrate strikingly specific nuclear and territorial arrangements of active genes as compared with inactive ones: on the periphery of their territories facing to the very central region of the cell nucleus. Nuclear arrangement of c-myc genes and transcripts was conserved during cell differentiation and, therefore, independent of the level of differentiation-specific c-myc gene expression. However, after the induction of differentiation, a more internal territorial location was found for the single copy c-myc gene of normal chromosome 8, while amplicons conserved their territorial topography.

  3. The complete mitochondrial genome of the mountainous duskywing, Erynnis montanus (Lepidoptera: Hesperiidae): a new gene arrangement in Lepidoptera.

    Wang, Ah Rha; Jeong, Heon Cheon; Han, Yeon Soo; Kim, Iksoo


    The mountainous duskywing, Erynnis montanus, belongs to a lepidopteran family Hesperiidae. The 15,530-bp long complete mitochondrial genome (mitogenome) of the species has the typical gene content of animals (13 protein-coding genes, two rRNA genes, 22 tRNA genes and one major non-coding A+T-rich region). As typical in lepidopteran mitogenome E. montanus mitogenome also contained a high A/T content in the whole genome (81.7%) and the CGA (arginine) as the start codon for the COI gene. Unlike other lepidopteran species, including two sequenced skippers, the E. montanus mitogenome has a unique arrangement tRNA(Ser)-tRNA(Asn), instead of the tRNA(Asn)-tRNA(Ser) found unanimously in other lepidopteran species, providing a new gene arrangement in Lepidoptera. Such rearrangement probably was likely caused by duplication of gene block tRNA(Ser)-tRNA(Asn) and subsequent random loss of tRNA(Asn) in the first copy and tRNA(Ser) in the second copy, resulting in the arrangement tRNA(Ser)-tRNA(Asn).

  4. Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position.

    Eszterhas, Susan K; Bouhassira, Eric E; Martin, David I K; Fiering, Steven


    Transcriptional interference is the influence, generally suppressive, of one active transcriptional unit on another unit linked in cis. Its wide occurrence in experimental systems suggests that it may also influence transcription in many loci, but little is known about its precise nature or underlying mechanisms. Here we report a study of the interaction of two nearly identical transcription units juxtaposed in various arrangements. Each reporter gene in the constructs has its own promoter and enhancer and a strong polyadenylation signal. We used recombinase-mediated cassette exchange (RMCE) to insert the constructs into previously tagged genomic sites in cultured cells. This strategy also allows the constructs to be assessed in both orientations with respect to flanking chromatin. In each of the possible arrangements (tandem, divergent, and convergent), the presence of two genes strongly suppresses expression of both genes compared to that of an identical single gene at the same integration site. The suppression is most severe with the convergent arrangement and least severe in total with the divergent arrangement, while the tandem arrangement is most strongly influenced by the integration site and the genes' orientation within the site. These results suggest that transcriptional interference could underlie some position effects and contribute to the regulation of genes in complex loci.

  5. The occurrence and distribution of 5-hydroxytryptamine in Hymenolepis diminuta and H. nana.

    Lee, M B; Bueding, E; Schiller, E L


    The presence of 5-HT in Hymenolepis diminuta and Hymenolepis nana was detected by 2 biochemical methods and as yellow fluorescence in a histochemical method. In H. diminuta, 5-HT was found in a concentration of about 1.2 micron/g; this amount did not vary significantly in worms aged 6 to 18 days or more or in various regions of the worm. In H. nana, 5-HT was found in a concentration of about 1.8 micron/g. It was histochemically localized in H. diminuta and H. nana in a pattern similar to that of acetylcholinesterase previously described in these 2 cestodes, and it may be the opposing neuro-transmitter to acetylcholine. The lack of 5-HT in the vestigial rostellum of H. diminuta may be correlated with loss of function of this organ.

  6. Identification and characterization of adult alpha-and beta-globin genes and their genomic arrangement in Pseudosciaena crocea

    CHU Wuying; QIAN Ronghua; WANG Lianshen; YU Xiameng; YOU Zhenqiang; YU Lian


    The α- and β-globin genes from Pseudosciaena crocea were cloned by rapid amplification of cDNA 3'-end (3'-RACE). The cDNA of the α-globin is 595 bp with the ATG start codon located at Position 37, the TAA stop codon at Position 469 and the AATAAA polyadenylation signal at Position 560, which codifies 145 amino acids. The entire open reading frame of the β-globin gene is 447 bp long, which encodes 148 amino acids. Amino acid identity of the α- globin or β-globin gene compared with those reported in other fish species, ranged from 31.9% to 76.4%. When comparing with human α- and β-globins, three important alterations in the structural regions can be noted: α39 Thr→Gln, α113 His→Tyr and β117 His→Lys. The α-globin has a unique inserted amino acid residue in the 47th position. To understand the process of globin gene duplication and identify the regulatory elements present in the intergenic and intragenic regions of globin genes, the genomic arrangement of α- and β-globin genes was investigated. The results showed that the orientation of the two genes was head-to-head relative to each other. The intergenic region between the translation initiation codons of the linked α- and β-globin genes contains classical promoter elements and the length of it is much shorter than that reported in other fish.

  7. Hymenolepis diminuta and H. nana: cross immunity against the lumen phase in BALB/c mice.

    Ito, A; Onitake, K


    When BALB/c mice initially given cysticercoids of Hymenolepis diminuta orally (Day 0) were challenged with eggs or cysticercoids of H. nana, almost all the mice became completely resistant to H. nana challenges from Day 30 onward, and no luminal adults of H. nana were established. There was a tendency for the number of tissue cysticercoids recovered 4 days after egg challenge in immunized mice to be much less than that in control mice (P less than 0.001, Student's t test). However, when these cysticercoids recovered from immune group mice were inoculated into uninfected mice, they matured in the lumen. Thus, the cross immunity to H. nana challenge evoked by an initial prepatent infection with H. diminuta appeared to be directed not against the tissue phase but against the lumen phase of H. nana. When BALB/c mice initially given eggs of H. nana were challenged with H. diminuta, they became resistant to H. diminuta from Day 15 onward. When the mice given eggs of H. nana were treated with a cestocide, praziquantel, at the beginning of the expected luminal development of H. nana and experienced a tissue phase only before challenge with H. diminuta, they showed no resistance to H. diminuta. Thus, the cross immunity to H. diminuta challenge evoked by an initial patent infection with H. nana appeared to be due to the immunogens of the lumen phase of H. nana but not those of the tissue phase. The cross immunity may be, therefore, essentially evoked by the lumen phase of these two phylogenetically closely related species and not by or against the tissue phase of H. nana.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Establishment of Hymenolepis Diminuta Life Cycle to Provide Parasite Mass Production

    MS Makki


    Full Text Available Background: The main object of this experimental work was to practise laboratory production both adult and the larval stage of Hymenolepis diminuta with conventional modification to make further studies easier.Materials & Method: Adults H. diminuta were collected from urban rats in Tehran, Iran. The beetles became infected using blended gravid segments with flour as bait. Cysticercoids have been saved after precise dissection of invertebrate hosts. The exposure of infected beetles to labora­tory rats was performed to establish the life cycle. Result: Out of 57 collected rats, three rats were infected with H. diminuta. Almost all exposed beetles found infected with the larval stage of parasite. About one-month later H. diminuta eggs were seen in stool examination of laboratory rats.Conclusion: Rare human occurrence of H. diminuta along with light level of clinical manifesta­tion of this parasite, underestimate the concerns toward its public health importance. Nowadays, various field of studies, such as biochemistry with special focuses on the capability of H. di­minuta tegument absorption have performed apart from parasitological views alone. In the pre­sent study, establishment of this parasite life cycle has practically provided the access of adult and cysticercoid stages of the tapeworm in further researches.

  9. Nitrate removal using Brevundimonas diminuta MTCC 8486 from ground water.

    Kavitha, S; Selvakumar, R; Sathishkumar, M; Swaminathan, K; Lakshmanaperumalsamy, P; Singh, A; Jain, S K


    Brevundimonas diminuta MTCC 8486, isolated from marine soil of coastal area of Trivandrum, Kerala, was used for biological removal of nitrate from ground water collected from Kar village of Pali district, Rajasthan. The organism was found to be resistance for nitrate up to 10,000 mg L(-1). The optimum growth conditions for biological removal of nitrate were established in batch culture. The effect of carbon sources on nitrate removal was investigated using mineral salt medium (MSM) containing 500 mg L(-1) of nitrate to select the most effective carbon source. Among glucose and starch as carbon source, glucose at 1% concentration increased the growth (182+/-8.24 x 10(4) CFU mL(-1)) and induced maximum nitrate reduction (86.4%) at 72 h. The ground water collected from Kar village, Pali district of Rajasthan containing 460+/-5.92 mg L(-1) of nitrate was subjected to three different treatment processes in pilot scale (T1 to T3). Higher removal of nitrate was observed in T2 process (88%) supplemented with 1% glucose. The system was scaled up to 10 L pilot scale treatment plant. At 72 h the nitrate removal was observed to be 95% in pilot scale plant. The residual nitrate level (23+/-0.41 mg L(-1)) in pilot scale treatment process was found to be below the permissible limit of WHO.

  10. Novel arrangement and comparative analysis of hsp90 family genes in three thermotolerant species of Stratiomyidae (Diptera).

    Astakhova, L N; Zatsepina, O G; Przhiboro, A A; Evgen'ev, M B; Garbuz, D G


    The heat shock proteins belonging to the Hsp90 family (Hsp83 in Diptera) play a crucial role in the protection of cells due to their chaperoning functions. We sequenced hsp90 genes from three species of the family Stratiomyidae (Diptera) living in thermally different habitats and characterized by extraordinarily high thermotolerance. The sequence variation and structure of the hsp90 family genes were compared with previously described features of hsp70 copies isolated from the same species. Two functional hsp83 genes were found in the species studied, that are arranged in tandem orientation at least in one of them. This organization was not previously described. Stratiomyidae hsp83 genes share a high level of identity with hsp83 of Drosophila, and the deduced protein possesses five conserved amino acid sequence motifs characteristic of the Hsp90 family as well as the C-terminus MEEVD sequence characteristic of the cytosolic isoform. A comparison of the hsp83 promoters of two Stratiomyidae species from thermally contrasting habitats demonstrated that while both species contain canonical heat shock elements in the same position, only one of the species contains functional GAF-binding elements. Our data indicate that in the same species, hsp83 family genes show a higher evolution rate than the hsp70 family.

  11. Mitochondrial genomes of Japanese Babina frogs (Ranidae, Anura): unique gene arrangements and the phylogenetic position of genus Babina.

    Kakehashi, Ryosuke; Kurabayashi, Atsushi; Oumi, Shohei; Katsuren, Seiki; Hoso, Masaki; Sumida, Masayuki


    Genus Babina is a member of Ranidae, a large family of frogs, currently comprising 10 species. Three of them are listed as endangered species. To identify mitochondrial (mt) genes suitable for future population genetic analyses for endangered species, we determined the complete nucleotide sequences of the mt genomes of 3 endangered Japanese Babina frogs, B. holsti, B. okinavana, and B. subaspera and 1 ranid frog Lithobates catesbeianus. The genes of NADH dehydrogenase subunit 5 (nad5) and the control region (CR) were found to have high sequence divergences and to be usable for population genetics studies. At present, no consensus on the phylogenetic position of genus Babina has been reached. To resolve this problem, we performed molecular phylogenetic analyses with the largest dataset used to date (11,345 bp from 2 ribosomal RNA- and 13 protein-encoding genes) in studies dealing with Babina phylogeny. These analyses revealed monophyly of Babina and Odorrana. It is well known that mt gene rearrangements of animals can provide usable phylogenetic information. Thus, we also compared the mt gene arrangements among Babina species and other related genera. Of the surveyed species, only L. catesbeianus manifested typical neobatrachian-type mt gene organization. In the B. okinavana, an additional pseudogene of tRNA-His (trnH) was observed in the CR downstream region. Furthermore, in the B. holsti and B. subaspera, the trnH/nad5 block was translocated from its typical position to the CR downstream region, and the translocated trnH became a pseudogene. The position of the trnH pseudogene is consistent with the translocated trnH position reported in Odorrana. Consequently, the trnH rearrangement seems to be a common ancestry characteristic (synapomorphy) of Babina and Odorrana. Based on the "duplication and deletion" gene rearrangement model, a single genomic duplication event can explain the order of derived mt genes found in Babina and Odorrana.

  12. [A rare case of Hymenolepis diminuta infection in a small child].

    Kılınçel, Özge; Öztürk, Cihadiye Elif; Gün, Emrah; Öksüz, Şükrü; Uzun, Hakan; Şahin, İdris; Kılıç, Nida


    Unlike Hymenolepis nana that transmits directly from person to person, the transmission of Hymenolepis diminuta to human is via accidentally ingesting of arthropods carrying cysticercoid larvae as intermediate host. In places with poor hygienic conditions, this cestod may cause seldom infections especially in children. Studies carried out on various populations have reported the prevalence rate of H.diminuta between 0.001% and 5.5%. Although the reported cases are mostly children, the disease can be seen in every age group. In this report, a pediatric case of H.diminuta infection is presented. A twenty one-month-old male patient with the symptoms of vomiting 3-4 times a day along with mud-like diarrhea continuing for a week was admitted to the pediatric outpatient clinic. According to the history, it was learned that the house where he lived was above a barn and there was a history of insect swallowing. Laboratory findings revealed iron-deficiency anemia. The macroscopic appearance of the stool was in a pale clay-like form, and by direct microscopic examination with lugol solution, 70-75 μm in diameter, thick-shelled and six central hookleted eggs that are characteristic for H.diminuta were identified. A six-day course of oral niclosamide was administered to the patient beginning with 500 mg on the first day and 250 mg on the following five days, together with the treatment for the iron deficiency anemia. After fifteen days, the oral niclosamide treatment was repeated. No H.diminuta eggs were detected in the parasitological examination performed one month after completion of the second round of treatment. This case has been presented to call attention to the importance of patient anamnesis and microscopic examination in the diagnosis of H.diminuta infection which is a rarely seen parasitosis.

  13. The complete mitochondrial genome of the tapeworm Cladotaenia vulturi (Cestoda: Paruterinidae): gene arrangement and phylogenetic relationships with other cestodes.

    Guo, Aijiang


    Tapeworms Cladotaenia spp. are among the most important wildlife pathogens in birds of prey. The genus Cladotaenia is placed in the family Paruterinidae based on morphological characteristics and hosts. However, limited molecular information is available for studying the phylogenetic position of this genus in relation to other cestodes. In this study, the complete mitochondrial (mt) genome of Cladotaenia vulturi was amplified using "Long-PCR" and then sequenced by primer walking. Sequence annotation and gene identification were performed by comparison with published flatworm mt genomes. The phylogenetic relationships of C. vulturi with other cestode species were established using the concatenated amino acid sequences of 12 protein-coding genes with Bayesian Inference and Maximum Likelihood methods. The complete mitochondrial genome of the Cladotaenia vulturi is 13,411 kb in size and contains 36 genes. The gene arrangement of C. vulturi is identical to those in Anoplocephala spp. (Anoplocephalidae), Hymenolepis spp. (Hymenolepididae) and Dipylidium caninum (Dipylidiidae), but different from that in taeniids owing to the order shift between the tRNA (L1) and tRNA (S2) genes. Phylogenetic analyses based on the amino acid sequences of the concatenated 12 protein-coding genes showed that the species in the Taeniidae form a group and C. vulturi is a sister taxon to the species of the family Taeniidae. To our knowledge, the present study provides the first molecular data to support the early proposal from morphological evidence that the Taeniidae is a sister group to the family Paruterinidae. This novel mt genome sequence will be useful for further investigations into the population genetics, phylogenetics and systematics of the family Paruterinidae and inferring phylogenetic relationships among several lineages within the order Cyclophyllidea.

  14. The complete mitochondrial genome of Neobenedenia melleni (Platyhelminthes: Monogenea): mitochondrial gene content, arrangement and composition compared with two Benedenia species.

    Zhang, Juan; Wu, Xiangyun; Li, Yanwei; Zhao, Mengwei; Xie, Mingquan; Li, Anxing


    The complete mitochondrial (mt) genome sequences of Neobenedenia melleni were determined and compared with those of Benedenia seriolae and B. hoshinai. This circular genome comprises 13,270 bp and includes all 36 typical mt genes found in flatworms. Total AT content of N. melleni is 75.9 %. ATG is the most common start codon, while nad4L is initiated by GTG. All protein-coding genes are predicted to terminate with TAG and TAA. N. melleni has the trnR with a TCG anticodon, which is the same to B. seriolae but different from B. hoshinai (ACG). The mt gene arrangement of N. melleni is similar to that of B. seriolae and B. hoshinai with the exception of three translocations (trnF, trnT and trnG). The overlapped region between nad4L and nad4 was found in the N. melleni mt genome, which was also reported for the published Gyrodactylus species, but it was not found in those of B. seriolae and B. hoshinai, which are non-coding regions instead. The present study provides useful molecular characters for species or strain identification and systematic studies of this parasite.

  15. Symbiotic Burkholderia Species Show Diverse Arrangements of nif/fix and nod Genes and Lack Typical High-Affinity Cytochrome cbb3 Oxidase Genes.

    De Meyer, Sofie E; Briscoe, Leah; Martínez-Hidalgo, Pilar; Agapakis, Christina M; de-Los Santos, Paulina Estrada; Seshadri, Rekha; Reeve, Wayne; Weinstock, George; O'Hara, Graham; Howieson, John G; Hirsch, Ann M


    Genome analysis of fourteen mimosoid and four papilionoid beta-rhizobia together with fourteen reference alpha-rhizobia for both nodulation (nod) and nitrogen-fixing (nif/fix) genes has shown phylogenetic congruence between 16S rRNA/MLSA (combined 16S rRNA gene sequencing and multilocus sequence analysis) and nif/fix genes, indicating a free-living diazotrophic ancestry of the beta-rhizobia. However, deeper genomic analysis revealed a complex symbiosis acquisition history in the beta-rhizobia that clearly separates the mimosoid and papilionoid nodulating groups. Mimosoid-nodulating beta-rhizobia have nod genes tightly clustered in the nodBCIJHASU operon, whereas papilionoid-nodulating Burkholderia have nodUSDABC and nodIJ genes, although their arrangement is not canonical because the nod genes are subdivided by the insertion of nif and other genes. Furthermore, the papilionoid Burkholderia spp. contain duplications of several nod and nif genes. The Burkholderia nifHDKEN and fixABC genes are very closely related to those found in free-living diazotrophs. In contrast, nifA is highly divergent between both groups, but the papilionoid species nifA is more similar to alpha-rhizobia nifA than to other groups. Surprisingly, for all Burkholderia, the fixNOQP and fixGHIS genes required for cbb3 cytochrome oxidase production and assembly are missing. In contrast, symbiotic Cupriavidus strains have fixNOQPGHIS genes, revealing a divergence in the evolution of two distinct electron transport chains required for nitrogen fixation within the beta-rhizobia.

  16. A confocal microscopy-based atlas of tissue architecture in the tapeworm Hymenolepis diminuta.

    Rozario, Tania; Newmark, Phillip A


    Tapeworms are pervasive and globally distributed parasites that infect millions of humans and livestock every year, and are the causative agents of two of the 17 neglected tropical diseases prioritized by the World Health Organization. Studies of tapeworm biology and pathology are often encumbered by the complex life cycles of disease-relevant tapeworm species that infect hosts such as foxes, dogs, cattle, pigs, and humans. Thus, studies of laboratory models can help overcome the practical, ethical, and cost-related difficulties faced by tapeworm parasitologists. The rat intestinal tapeworm Hymenolepis diminuta is easily reared in the laboratory and has the potential to enable modern molecular-based experiments that will greatly contribute to our understanding of multiple aspects of tapeworm biology, such as growth and reproduction. As part of our efforts to develop molecular tools for experiments on H. diminuta, we have characterized a battery of lectins, antibodies, and common stains that label different tapeworm tissues and organ structures. Using confocal microscopy, we have assembled an "atlas" of H. diminuta organ architecture that will be a useful resource for helminthologists. The methodologies we describe will facilitate characterization of loss-of-function perturbations using H. diminuta. This toolkit will enable a greater understanding of fundamental tapeworm biology that may elucidate new therapeutic targets toward the eradication of these parasites.

  17. Genes involved in degradation of para-nitrophenol are differentially arranged in form of non-contiguous gene clusters in Burkholderia sp. strain SJ98.

    Surendra Vikram

    Full Text Available Biodegradation of para-Nitrophenol (PNP proceeds via two distinct pathways, having 1,2,3-benzenetriol (BT and hydroquinone (HQ as their respective terminal aromatic intermediates. Genes involved in these pathways have already been studied in different PNP degrading bacteria. Burkholderia sp. strain SJ98 degrades PNP via both the pathways. Earlier, we have sequenced and analyzed a ~41 kb fragment from the genomic library of strain SJ98. This DNA fragment was found to harbor all the lower pathway genes; however, genes responsible for the initial transformation of PNP could not be identified within this fragment. Now, we have sequenced and annotated the whole genome of strain SJ98 and found two ORFs (viz., pnpA and pnpB showing maximum identity at amino acid level with p-nitrophenol 4-monooxygenase (PnpM and p-benzoquinone reductase (BqR. Unlike the other PNP gene clusters reported earlier in different bacteria, these two ORFs in SJ98 genome are physically separated from the other genes of PNP degradation pathway. In order to ascertain the identity of ORFs pnpA and pnpB, we have performed in-vitro assays using recombinant proteins heterologously expressed and purified to homogeneity. Purified PnpA was found to be a functional PnpM and transformed PNP into benzoquinone (BQ, while PnpB was found to be a functional BqR which catalyzed the transformation of BQ into hydroquinone (HQ. Noticeably, PnpM from strain SJ98 could also transform a number of PNP analogues. Based on the above observations, we propose that the genes for PNP degradation in strain SJ98 are arranged differentially in form of non-contiguous gene clusters. This is the first report for such arrangement for gene clusters involved in PNP degradation. Therefore, we propose that PNP degradation in strain SJ98 could be an important model system for further studies on differential evolution of PNP degradation functions.

  18. Identification and properties of two extracellular proteases from Brevundimonas diminuta Identificação e propriedades de duas proteases extracelulares de Brevundimonas diminuta

    André Adriano Chaia


    Full Text Available Extracellular proteases from Brevundimonas diminuta (syn. Pseudomonas diminuta were studied in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE containing a copolymerized substrate. Two proteases were detected migrating at 67 kDa and 50 kDa: both of them hydrolysed preferentially gelatin, but casein was also degraded and a slight hydrolysis was observed with hemoglobin. No detectable extracellular proteolytic activity was found in bovine serum albumin-containing gels. The optima temperature and pH for proteolytic activity were between 40ºC and 50ºC in a pH ranging from 7.0 to 11.0, respectively. These enzymes were isolated by analytical high performance liquid chromatography (HPLC. Protease assays with the synthetic substrate Z-Phe-Arg-MCA and the inhibitors EGTA, EDTA and 1, 10 phenanthroline point out that these enzymes are metalloproteases.Proteases extracelulares de Brevundimonas diminuta (Pseudomonas diminuta foram identificadas e caracterizadas por eletroforese em gel de poliacrilamida com dodecilsulfato de sódio, contendo um substrato co-polimerizado. Duas proteases foram detectadas migrando em 67 kDa e 50 kDa: ambas hidrolisaram preferencialmente a gelatina, embora a caseína também tenha sido degradada e uma pequena hidrólise tenha sido observada com hemoglobina. Nenhuma atividade proteolítica extracelular foi detectada nos géis contendo soro albumina bovina. Condições ótimas de temperatura e pH para a atividade proteolítica foram observadas entre 40ºC e 50ºC e numa faixa de pH que variou de 7,0 a 11,0, respectivamente. Essas enzimas foram isoladas por cromatografia líquida de alta resolução. Os ensaios enzimáticos com o substrato sintético Z-Phe-Arg-MCA e com os inibidores EGTA, EDTA e 1, 10 fenantrolina indicam que essas enzimas são metaloproteases.

  19. A method for measuring the attachment strength of the cestode Hymenolepis diminuta to the rat intestine.

    Xie, W; Racz, G R; Terry, B S; Gardner, S L


    A unique adaptation of many internal parasites of mammals is their ability to stay in the intestine for extended periods of time and resist the normal peristaltic movements and forces that push and expel material. To better understand parasite adhesion behaviour and replicate their attachment method in medical devices, an experiment was designed and performed using the rat tapeworm, Hymenolepis diminuta. The experiment employed a tensile test machine and a digital scale and was designed to calculate the attachment strength of the scolex to the mucosa through the change of the value of the digital scale during the tensile test. The attachment force of H. diminuta is 0.021 ± 0.011 g. This method could be applied in studies of parasite biomechanics and the results may help medical device researchers to better mimic the unique functional morphology of this species of parasite.

  20. Effect of an intraperitoneal injection with activated Hymenolepis nana and H. diminuta cysticercoids on homologous challenge.

    Gabriele, F; Bortoletti, G; Conchedda, M; Palmas, C


    The intraperitoneal injection of excysted-activated cysticercoids of Hymenolepis nana and H. diminuta stimulates a protective immunity in mice and rats against an oral homologous challenge with different levels of effectiveness. The immunizing dose reduced only worm growth in the natural host (i.e. H. nana/mouse and H. diminuta/rat models), while in the unnatural host (i.e. H. diminuta/mouse model) expulsion of the worms from the intestine was accelerated. In mice infected with H. nana the effect appeared about 20 days after injection, but a greater effect was found in both models 40 days later even at low dose (1 cysticercoid). In rats the effect appeared 40 days after injection when a large inoculum (50 or 100 cysticercoids) was used. The induced immunity was slow in developing and only partially effective: this was probably related to host difficulties in processing somatic worm antigens, or to the slow production of metabolites by the worms in the peritoneal cavity.

  1. Registro de Xenopsylla cheopis como hospedero intermediario natural de Hymenolepis diminuta en Lima, Perú

    Inés Gárate


    Full Text Available Con el objetivo de determinar el rol de las pulgas de las ratas en el ciclo biológico de Hymenolepis diminuta, entre noviembre del 2009 y marzo del 2010, se capturaron 27 ratas del Cercado de Lima y examinaron sus ectoparásitos, empleando los procedimientos parasitológicos estándares. De las ratas examinadas, 22 (81,5% de las ratas examinadas estuvieron infectadas con el parásito H. diminuta, el 85,2% de ratas estuvo infestado por sifonápteros de la especie Xenopsylla cheopis. De las 158 pulgas encontradas, el 12% albergaba cisticercoides en su hemocele, los que al ser inoculados en ratas albinas de la cepa Holtzman, desarrollaron hasta el estadio de adultos de la especie Hymenolepis diminuta. Los resultados del presente trabajo son concluyentes y constituyen el primer registro del rol de X. cheopis como hospedero intermediario natural en Perú, por lo que es necesario reconsiderar los factores de riesgo y las medidas de prevención.

  2. In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm.

    Vijaya; Yadav, Arun K


    A large number of medicinal plants are used as herbal remedy for the treatment of helminthic diseases in the developing countries, however, far too little attention has been paid to assess the anthelmintic potentials of chemical compounds that are present in these plants. This study was carried out to assess the in vitro anthelmintic effects of biochanin A, ursolic acid, betulinic acid and beta-sitosterol which are the major phytochemicals of Trifolium repens, Houttuynia cordata and Lasia spinosa, the traditionally used anthelmintic plants of Northeast India. The in vitro anthelmintic testing of these phytochemicals was undertaken against Hymenolepis diminuta, a zoonotic tapeworm, and their efficacy was compared with a reference drug, praziquantel. The results revealed that except beta-sitosterol, which showed a very weak anthelmintic effect, remaining all other tested compounds possess highly significant (p ≤ 0.001) and dose-dependent anthelmintic effects. Upon exposure to 0.25, 0.50 and 1 mg/ml concentrations of biochanin A, ursolic acid and betulinic acid, the test parasite H. diminuta, at first, showed a paralyzed state which later culminated into their mortality after short time periods. Of all the phytochemicals tested, betulinic acid (1 mg/ml) showed the best anthelmintic effect and caused the mortality of test parasites at 3.4 ± 0.66 h. In conclusion, the results of this study demonstrate for the first time that betulinic acid, biochanin A and ursolic acid possess significant in vitro anthelmintic effects against H. diminuta, a zoonotic tapeworm, and, therefore, these compounds may be exploited further for anthelmintic drug development.

  3. Experimental infection of Tribolium confusum (Coleoptera) by Hymenolepis diminuta (Cestoda): host fecundity during infection.

    Maema, M


    Some effects of Hymenolepis diminuta on the fecundity of Tribolium confusum are described. Host fecundity is observed to be reduced exponentially with increasing parasite burden/host, although there are differences in the ability of individual hosts to respond to parasitism. Of particular interest is the finding that host fecundity is greatly reduced in young beetles on or by day 14 post-infection (p.i.). This age-related reduction in host fecundity is discussed in relation to the population dynamics of this host-parasite relationship.

  4. Evaluación experimental de Ulomoides dermestoides (Tenebrionidae como hospedero intermediario de Hymenolepis diminuta

    Diana Villegas-Fudino

    Full Text Available El objetivo del estudio fue determinar si Ulomoides dermestoides se comporta como hospedero intermediario de Hymenolepis diminuta, por lo que cien de ellos se infectaron experimentalmente con huevos del cestodo. Como resultado se obtuvo que en el 92% de los insectos se formaron cisticercoides que, inoculados en ratas de laboratorio, desarrollaron el estadio adulto con cuyos huevos se repitieron nuevas infecciones obteniendo los mismos resultados, por lo que se puede señalar que U. dermestoides experimentalmente se comporta como hospedero intermediario

  5. Bioaccumulation of silver and the isolation of metal-binding protein from P.diminuta

    Zaharah Ibrahim


    Full Text Available A silver uptake study by Pseudomonas diminuta was carried out by growing the bacteria in a chloride-free medium (CFM containing silver ions (50 muM in a batch culture. From the results, it was found that higher amounts of silver were accumulated inside the cell during early exponential phase compared to the amount bound at the cell surface. This suggested a possible mechanism for metal uptake during bacterial growth. In view of this, attempts were made to isolate proteins which might be associated with silver-binding properties from cultures of P.diminuta grown in the presence and absence of silver. The proteins were first extracted from the bacterial cultures by precipitation with ammonium sulfate followed by purification using isoelectric focussing and SDS-PAGE. Results of the experiment showed the presence of low molecular weight and high molecular weight proteins containing silver with pI values ranging from 2.0 to 9.0 for bacteria grown in the presence of silver.Um estudo sobre o crescimento de Pseudomonas diminuta em um meio contendo cloreto livre (CFM e íons de prata na concentração (50 µM em uma cultura em batelada. Os resultados demonstraram que grandes quantidades de prata foram acumuladas dentro da célula durante a fase exponencial de crescimento comparada à uma quantidade limitada na superfície da célula. Isto sugeriu um mecanismo captação do metal durante o crescimento bacteriano. Em vista disto, tentativas foram realizadas no sentido de isolar as proteínas relacionadas com a propriedade de se ligar a prata em cultura P.diminuta em um meio contendo ou não íons prata. As proteínas foram extraídas das culturas bacterianas pela precipitação com o sulfato do amônio seguido de sua purificação utilizando um focalizador isoelétrico e SDS-PAGE. Os resultados desta experiência mostraram a presença de proteínas de alto e baixo peso molecular contendo prata com pI variando entre 2,0 a 9,0 quando as bactérias crescem na

  6. The Complete Mitochondrial Genome of Aleurocanthus camelliae: Insights into Gene Arrangement and Genome Organization within the Family Aleyrodidae.

    Chen, Shi-Chun; Wang, Xiao-Qing; Li, Pin-Wu; Hu, Xiang; Wang, Jin-Jun; Peng, Ping


    There are numerous gene rearrangements and transfer RNA gene absences existing in mitochondrial (mt) genomes of Aleyrodidae species. To understand how mt genomes evolved in the family Aleyrodidae, we have sequenced the complete mt genome of Aleurocanthus camelliae and comparatively analyzed all reported whitefly mt genomes. The mt genome of A. camelliae is 15,188 bp long, and consists of 13 protein-coding genes, two rRNA genes, 21 tRNA genes and a putative control region (GenBank: KU761949). The tRNA gene, trnI, has not been observed in this genome. The mt genome has a unique gene order and shares most gene boundaries with Tetraleurodes acaciae. Nineteen of 21 tRNA genes have the conventional cloverleaf shaped secondary structure and two (trnS₁ and trnS₂) lack the dihydrouridine (DHU) arm. Using ARWEN and homologous sequence alignment, we have identified five tRNA genes and revised the annotation for three whitefly mt genomes. This result suggests that most absent genes exist in the genomes and have not been identified, due to be lack of technology and inference sequence. The phylogenetic relationships among 11 whiteflies and Drosophila melanogaster were inferred by maximum likelihood and Bayesian inference methods. Aleurocanthus camelliae and T. acaciae form a sister group, and all three Bemisia tabaci and two Bemisia afer strains gather together. These results are identical to the relationships inferred from gene order. We inferred that gene rearrangement plays an important role in the mt genome evolved from whiteflies.

  7. Complete mitochondrial DNA sequence of the endangered frog Odorrana ishikawae (family Ranidae) and unexpected diversity of mt gene arrangements in ranids.

    Kurabayashi, Atsushi; Yoshikawa, Natsuhiko; Sato, Naoki; Hayashi, Yoko; Oumi, Shohei; Fujii, Tamotsu; Sumida, Masayuki


    We determined the complete nucleotide sequence of the mitochondrial (mt) genome of an endangered Japanese frog, Odorrana ishikawae (family Ranidae). We also sequenced partial mt genomes of three other Odorrana and six ranid species to survey the diversity of genomic organizations and elucidate the phylogenetic problems remaining in this frog family. The O. ishikawae mt genome contained the 37 mt genes and single control region (CR) typically found in vertebrate mtDNAs, but the region of Light-strand replication origin (OL) was triplicated in this species. Four protein-encoding genes (atp6, nd2, nd3, and nd5) were found to have high sequence divergence and to be usable for population genetics studies on this endangered species. Among the surveyed ranids, only two species (Rana and Lithobates) manifested the typical neobatrachian-type mt gene arrangement. In contrast, relatively large gene rearrangements were found in Amolops, Babina, and Staurois species; and translocations of single tRNA genes (trns) were observed in Glandirana and Odorrana species. Though the inter-generic and interspecific relationships of ranid taxa remain to be elucidated based on 12S and 16S rrn sequence data, some of the derived mt gene orders were found to have synapomorphic features useful for solving problematic ranid phylogenies. The tandem duplication and random loss (TDRL) model, the traditional model for mt gene rearrangement, failed to easily explain several of the mt gene rearrangements observed here. Indeed, the recent recombination-based gene rearrangement models seemed to be more suitable for this purpose. The high frequency of gene translocations involving a specific trn block (trnH-trnS1) and several single tRNA genes suggest that there may be a retrotranslocation in ranid mt genomes.

  8. Immunogenicity and phylogenetic relationship of tapeworm antigens produced by Hymenolepis nana and Hymenolepis diminuta

    Coleman, R. M.; Carty, Janice M.; Graziadei, W. D.


    The tapeworms Hymenolepis nana and H. diminuta share three major antigens in the cell sap. Two of these show identical specificity while the third exhibits common as well as uncommon determinants peculiar to the dwarf tapeworm, H. nana. Shared antigens are not, however, immunogenic during infection of mice with the dwarf tapeworm although there is a well defined response to specific antigens. On the other hand infection of rats with H. diminuta elicits a weak response yielding serum antibodies which cross-react with the dwarf tapeworm. Cross-reactive antibodies engendered in rabbits against worm homogenates are insensitive to mercaptoethanol treatment whereas non-cross-reactive antibodies present at 3 weeks post-infection with the dwarf tapeworm are primarily IgM globulins. The rapid formation and subsequent release of these antigens may relate to a persistence of immunogenicity. Antibody levels reach a peak after a 4-week period of infection and the drop in titre observed at 6 weeks is preceded by a reduction in worm load. Resistance to infection following artificial immunization with worm homogenates is consistent with that developed as a result of actual infection with the dwarf tapeworm. Over one-half of mice immunized did not become infected following challenge with ova. Worm loads of mice that did become infected were reduced to approximately 1 per cent that of non-immunized animals. PMID:5673286

  9. Coinfection with Hymenolepis nana, Hymenolepis diminuta, Giardia intestinalis, and Human Immunodeficiency Virus: A Case Report with Complex Immunologic Interactions.

    Pérez-Chacón, Gladymar; Pocaterra, Leonor A; Rojas, Elsy; Hernán, Aurora; Jiménez, Juan Carlos; Núñez, Luz


    We describe the case of a 43-year-old human immunodeficiency virus-infected man receiving combined antiretroviral therapy and coinfected with Hymenolepis nana, Hymenolepis diminuta, and Giardia intestinalis, presenting as chronic diarrhea and critical weight loss. Immunological aspects of these interactions are reviewed.

  10. Population of Pratylenchus coffeae (Z. and growth of Arabica coffee seedling inoculated by Pseudomonas diminuta L. and Bacillus subtilis (C..

    Irfan Fauzi


    Full Text Available AbstractPratylenchus coffeae is a parasitic nematoda that infected the roots of some plants, one of them is coffee. The Infection of Pratylenchus coffeae cause root tissue damage that led to root lession and make root become rotten, it will interfere the ability of roots to absorb water and nutrients in the soil which resulted in the growth of plants. At the moment, control of Pratylenchus coffeae are following integrated pests management (IPM program, which integrated between the use of coffee resistant clone and application of biological agents. Research on biological control was conducted more intensive, at the moment; due to it is friendlier save against environment and cheaper then using chemical nematicides. The research was conducted to know the effects of Micorrhiza Helper Bacteria (MHB,Pseudomonas diminuta and Bacillus subtilis in suppressing the population of P. coffeaeas well as their effect on growth of coffee seedling.  Coffee arabica (Coffea arabica L. seedling one moth old were used in the experiment. The experiment prepared with eight treatments and five  replications, as follows: A (Pseudomonas diminuta with density of 108 cfu / ml, B (Pseudomonas diminuta with density of 2x108 cfu / ml, C (Bacillus subtilis with density of 108 cfu / ml , D (Bacillus subtilis with density 2x108 cfu / ml, E (Carbofuran nematicide 5 g formulation / pot, F (Pseudomonas diminuta and Bacillus subtilis with each density of 108 cfu / ml, K- (Nematoda inoculation but without bacteria and nematicide, K+ (coffee seedling  without any additional treatment. The experiment was conducted for sixteen weeks or about four months. The results of the experiment showed that application of MHB could suppress population of P. coffeae and increase coffee seedling growth significantly. Inoculation of B. subtilis at 108 cfu per seedling suppressed significantly nematoda population of 71.3% compared with untreated seedling but inoculated with nematoda. It was not

  11. Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence.

    Bao, Yunjuan; Liang, Zhong; Booyjzsen, Claire; Mayfield, Jeffrey A; Li, Yang; Lee, Shaun W; Ploplis, Victoria A; Song, Hui; Castellino, Francis J


    The first genome sequence of a group A Streptococcus pyogenes serotype M23 (emm23) strain (M23ND), isolated from an invasive human infection, has been completed. The genome of this opacity factor-negative (SOF(-)) strain is composed of a circular chromosome of 1,846,477 bp. Gene profiling showed that this strain contained six phage-encoded and 24 chromosomally inherited well-known virulence factors, as well as 11 pseudogenes. The bacterium has acquired four large prophage elements, ΦM23ND.1 to ΦM23ND.4, harboring genes encoding streptococcal superantigen (ssa), streptococcal pyrogenic exotoxins (speC, speH, and speI), and DNases (spd1 and spd3), with phage integrase genes being present at one flank of each phage insertion, suggesting that the phages were integrated by horizontal gene transfer. Comparative analyses revealed unique large-scale genomic rearrangements that result in genomic rearrangements that differ from those of previously sequenced GAS strains. These rearrangements resulted in an imbalanced genomic architecture and translocations of chromosomal virulence genes. The covS sensor in M23ND was identified as a pseudogene, resulting in the attenuation of speB function and increased expression of the genes for the chromosomal virulence factors multiple-gene activator (mga), M protein (emm23), C5a peptidase (scpA), fibronectin-binding proteins (sfbI and fbp54), streptolysin O (slo), hyaluronic acid capsule (hasA), streptokinase (ska), and DNases (spd and spd3), which were verified by PCR. These genes are responsible for facilitating host epithelial cell binding and and/or immune evasion, thus further contributing to the virulence of M23ND. In conclusion, strain M23ND has become highly pathogenic as the result of a combination of multiple genetic factors, particularly gene composition and mutations, prophage integrations, unique genomic rearrangements, and regulated expression of critical virulence factors.

  12. Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages.

    Reyes, José L; Wang, Arthur; Fernando, Maria R; Graepel, Rabea; Leung, Gabriella; van Rooijen, Nico; Sigvardsson, Mikael; McKay, Derek M


    Helminth parasites provoke multicellular immune responses in their hosts that can suppress concomitant disease. The gut lumen-dwelling tapeworm Hymenolepis diminuta, unlike other parasites assessed as helminth therapy, causes no host tissue damage while potently suppressing murine colitis. With the goal of harnessing the immunomodulatory capacity of infection with H. diminuta, we assessed the putative generation of anti-colitic regulatory B cells following H. diminuta infection. Splenic CD19(+) B cells isolated from mice infected 7 [HdBc(7(d))] and 14 d (but not 3 d) previously with H. diminuta and transferred to naive mice significantly reduced the severity of dinitrobenzene sulfonic acid (DNBS)-, oxazolone-, and dextran-sodium sulfate-induced colitis. Mechanistic studies with the DNBS model, revealed the anti-colitic HdBc(7(d)) was within the follicular B cell population and its phenotype was not dependent on IL-4 or IL-10. The HdBc(7(d)) were not characterized by increased expression of CD1d, CD5, CD23, or IL-10 production, but did spontaneously, and upon LPS plus anti-CD40 stimulation, produce more TGF-β than CD19(+) B cells from controls. DNBS-induced colitis in RAG1(-/-) mice was inhibited by administration of HdBc(7(d)), indicating a lack of a requirement for T and B cells in the recipient; however, depletion of macrophages in recipient mice abrogated the anti-colitic effect of HdBc(7(d)). Thus, in response to H. diminuta, a putatively unique splenic CD19(+) B cell with a functional immunoregulatory program is generated that promotes the suppression of colitis dominated by TH1, TH2, or TH1-plus-TH2 events, and may do so via the synthesis of TGF-β and the generation of, or cooperation with, a regulatory macrophage.

  13. The complete mitochondrial genome of the house dust mite Dermatophagoides pteronyssinus (Trouessart: a novel gene arrangement among arthropods

    Vanholme Bartel


    Full Text Available Abstract Background The apparent scarcity of available sequence data has greatly impeded evolutionary studies in Acari (mites and ticks. This subclass encompasses over 48,000 species and forms the largest group within the Arachnida. Although mitochondrial genomes are widely utilised for phylogenetic and population genetic studies, only 20 mitochondrial genomes of Acari have been determined, of which only one belongs to the diverse order of the Sarcoptiformes. In this study, we describe the mitochondrial genome of the European house dust mite Dermatophagoides pteronyssinus, the most important member of this largely neglected group. Results The mitochondrial genome of D. pteronyssinus is a circular DNA molecule of 14,203 bp. It contains the complete set of 37 genes (13 protein coding genes, 2 rRNA genes and 22 tRNA genes, usually present in metazoan mitochondrial genomes. The mitochondrial gene order differs considerably from that of other Acari mitochondrial genomes. Compared to the mitochondrial genome of Limulus polyphemus, considered as the ancestral arthropod pattern, only 11 of the 38 gene boundaries are conserved. The majority strand has a 72.6% AT-content but a GC-skew of 0.194. This skew is the reverse of that normally observed for typical animal mitochondrial genomes. A microsatellite was detected in a large non-coding region (286 bp, which probably functions as the control region. Almost all tRNA genes lack a T-arm, provoking the formation of canonical cloverleaf tRNA-structures, and both rRNA genes are considerably reduced in size. Finally, the genomic sequence was used to perform a phylogenetic study. Both maximum likelihood and Bayesian inference analysis clustered D. pteronyssinus with Steganacarus magnus, forming a sistergroup of the Trombidiformes. Conclusion Although the mitochondrial genome of D. pteronyssinus shares different features with previously characterised Acari mitochondrial genomes, it is unique in many ways. Gene

  14. The complete mitochondrial genomes of two weevils, Eucryptorrhynchus chinensis and E. brandti: conserved genome arrangement in Curculionidae and deficiency of tRNA-Ile gene

    Liu Zhen-Kai


    Full Text Available The weevils Eucryptorrhynchus chinensis and Eucryptorrhynchus brandti (Coleoptera: Curculionidae, are two of the most important pests of the tree-of-heaven, Ailanthus altissima, which is found throughout China. In this study, the complete mitogenomes of the two weevils have been sequenced using Illumina HiSeqTM 2000. The mitogenomes of E. chinensis and E. brandti are 15,628bp and 15,597bp long with A+T contents of 77.7% and 76.6%, respectively. Both species have typical circular mitochondrial genomes that encode 36 genes. Except the deficiency of tRNA-Ile, the gene composition and order of E. chinensis and E. brandti are identical to the inferred ancestral gene arrangement of insects. In both mitochondrial genomes, the start codons for COI and ND1 are AAT and TTG, respectively. A5bp motif (TACTA is detected in intergenic region between the tRNA-Ser (UCN and ND1 genes. The ATP8/ATP6 and ND4L/ND4 gene pairs appear to overlap four or seven nucleotides (ATAA/ATGATAA in different reading frames. The complete sequences of AT-rich region have two regions including tandem repeats. The study identifies useful genetic markers for studying the population genetics, molecular identification and phylogeographics of Eucryptorrhynchus weevils. The features of the mitochondrial genomes are expected to be valuable in

  15. The complete mitochondrial genome and novel gene arrangement of the unique-headed bug Stenopirates sp. (Hemiptera: Enicocephalidae.

    Hu Li

    Full Text Available Many of true bugs are important insect pests to cultivated crops and some are important vectors of human diseases, but few cladistic analyses have addressed relationships among the seven infraorders of Heteroptera. The Enicocephalomorpha and Nepomorpha are consider the basal groups of Heteroptera, but the basal-most lineage remains unresolved. Here we report the mitochondrial genome of the unique-headed bug Stenopirates sp., the first mitochondrial genome sequenced from Enicocephalomorpha. The Stenopirates sp. mitochondrial genome is a typical circular DNA molecule of 15, 384 bp in length, and contains 37 genes and a large non-coding fragment. The gene order differs substantially from other known insect mitochondrial genomes, with rearrangements of both tRNA genes and protein-coding genes. The overall AT content (82.5% of Stenopirates sp. is the highest among all the known heteropteran mitochondrial genomes. The strand bias is consistent with other true bugs with negative GC-skew and positive AT-skew for the J-strand. The heteropteran mitochondrial atp8 exhibits the highest evolutionary rate, whereas cox1 appears to have the lowest rate. Furthermore, a negative correlation was observed between the variation of nucleotide substitutions and the GC content of each protein-coding gene. A microsatellite was identified in the putative control region. Finally, phylogenetic reconstruction suggests that Enicocephalomorpha is the sister group to all the remaining Heteroptera.

  16. Tapeworm (Hymenolepis diminuta) infection in flour beetles (Tribolium confusum): does it cause a trade-off between host fecundity and egg size?

    Shostak, Allen W


    .... Many animals also vary egg size in response to environmental conditions. Infection of flour beetles Tribolium confusum Jaquelin Du Val, 1868 with the rat tapeworm Hymenolepis diminuta (Rudolphi, 1819...

  17. Next-Generation Sequencing of Two Mitochondrial Genomes from Family Pompilidae (Hymenoptera: Vespoidea Reveal Novel Patterns of Gene Arrangement

    Peng-Yan Chen


    Full Text Available Animal mitochondrial genomes have provided large and diverse datasets for evolutionary studies. Here, the first two representative mitochondrial genomes from the family Pompilidae (Hymenoptera: Vespoidea were determined using next-generation sequencing. The sequenced region of these two mitochondrial genomes from the species Auplopus sp. and Agenioideus sp. was 16,746 bp long with an A + T content of 83.12% and 16,596 bp long with an A + T content of 78.64%, respectively. In both species, all of the 37 typical mitochondrial genes were determined. The secondary structure of tRNA genes and rRNA genes were predicted and compared with those of other insects. Atypical trnS1 using abnormal anticodons TCT and lacking D-stem pairings was identified. There were 49 helices belonging to six domains in rrnL and 30 helices belonging to three domains in rrns present. Compared with the ancestral organization, four and two tRNA genes were rearranged in mitochondrial genomes of Auplopus and Agenioideus, respectively. In both species, trnM was shuffled upstream of the trnI-trnQ-trnM cluster, and trnA was translocated from the cluster trnA-trnR-trnN-trnS1-trnE-trnF to the region between nad1 and trnL1, which is novel to the Vespoidea. In Auplopus, the tRNA cluster trnW-trnC-trnY was shuffled to trnW-trnY-trnC. Phylogenetic analysis within Vespoidea revealed that Pompilidae and Mutillidae formed a sister lineage, and then sistered Formicidae. The genomes presented in this study have enriched the knowledge base of molecular markers, which is valuable in respect to studies about the gene rearrangement mechanism, genomic evolutionary processes and phylogeny of Hymenoptera.

  18. Genome-wide characterization of vibrio phage ϕpp2 with unique arrangements of the mob-like genes

    Lin Ying-Rong


    Full Text Available Abstract Background Vibrio parahaemolyticus is associated with gastroenteritis, wound infections, and septicemia in human and animals. Phages can control the population of the pathogen. So far, the only one reported genome among giant vibriophages is KVP40: 244,835 bp with 26% coding regions that have T4 homologs. Putative homing endonucleases (HE were found in Vibrio phage KVP40 bearing one segD and Vibrio cholerae phage ICP1 carrying one mobC/E and one segG. Results A newly isolated Vibrio phage ϕpp2, which was specific to the hosts of V. parahaemolyticus and V. alginolyticus, featured a long nonenveloped head of ~90 × 150 nm and tail of ~110 nm. The phage can survive at 50°C for more than one hour. The genome of the phage ϕpp2 was sequenced to be 246,421 bp, which is 1587 bp larger than KVP40. 383 protein-encoding genes (PEGs and 30 tRNAs were found in the phage ϕpp2. Between the genomes of ϕpp2 and KVP40, 254 genes including 29 PEGs for viral structure were of high similarity, whereas 17 PEGs of KVP40 and 21 PEGs of ϕpp2 were unmatched. In both genomes, the capsid and tail genes have been identified, as well as the extensive representation of the DNA replication, recombination, and repair enzymes. In addition to the three giant indels of 1098, 1143 and 3330 nt, ϕpp2 possessed unique proteins involved in potassium channel, gp2 (DNA end protector, tRNA nucleotidyltransferase, and mob-type HEs, which were not reported in KVP40. The ϕpp2 PEG274, with strong promoters and translational initiation, was identified to be a mobE type, flanked by NrdA and NrdB/C homologs. Coincidently, several pairs of HE-flanking homologs with empty center were found in the phages of Vibrio phages ϕpp2 and KVP40, as well as in Aeromonas phages (Aeh1 and Ae65, and cyanophage P-SSM2. Conclusions Vibrio phage ϕpp2 was characterized by morphology, growth, and genomics with three giant indels and different types of HEs. The gene analysis on the required

  19. The influence of Hymenolepis diminuta on the survival and fecundity of the intermediate host, Tribolium confusum.

    Keymer, A E


    An experimental study of the effects of parasitism by H. diminuta on the intermediate host, Tribolium confusum, is described. No density-dependent constraints on parasite establishment within individual hosts are evident, although a reduction in cysticercoid size at high parasite burdens is demonstrated. The relationship between parasite burden, host mortality and host fecundity is investigated. Host mortality is linearly related to parasite burden, whereas the relationship between parasite burden and host fecundity is non-linear. There is no difference in viability between eggs from infected and uninfected females. The generative causes of these effects are not investigated experimentally, although it is postulated that survival is related to the degree of damage to the midgut wall caused by parasite penetration, and fecundity to the biomass of parasites harboured by the host. The significance of these effects is discussed in relation to the overall dynamics of the host-parasite association.

  20. Senna leaf extracts induced Ca(+2) homeostasis in a zoonotic tapeworm Hymenolepis diminuta.

    Roy, Saptarshi; Kundu, Suman; Lyndem, Larisha M


    Context Plants and plant products have been used in traditional medicine as anthelmintic agents in human and veterinary medicine. Three species of Senna plant, S. alata (L), S. alexandrina (M) and S. occidentalis (L.) Link (Fabaceae) have been shown to have a vermicidal/vermifugal effect on a zoonotic tapeworm Hymenolepis diminuta (Rudolphi) (Cyclophyllidean). Objective The present study validates the mode of action of these Senna plants on the parasite. The alcoholic leaf extract was determined to obtain information on the intracellular free calcium concentration level. Materials and methods Hymenolepis diminuta was maintained in Sprague-Dawley rat model for 2 months. Live parasites collected from infected rat intestine were exposed to 40 mg/mL concentration of each plant extracts prepared in phosphate buffer saline at 37 °C, till parasite gets paralyzed. The rate of efflux of calcium from the parasite tissue to the medium and the level of intracellular Ca(2+ )concentration were determined by an atomic absorption spectroscopy. Results This study revealed that exposure of the worms to the plant extract leads to disruption in intracellular calcium homeostasis. A significant increase (44.6% and 25%) of efflux in Ca(2+ )from the tissue to the incubated medium was observed. Senna alata showed high rate of efflux (5.32 mg/g) followed by S. alexandria and S. occidentalis (both 4.6 mg/g) compared with control (3.68 mg/g). Discussion and conclusion These results suggest that leaf extracts caused membrane permeability to Ca(2+ )after vacuolization of the tegument under stress and the extracts may contain compound that can be used as a chemotherapeutic agent.

  1. A balanced t(5;17 (p15;q22-23 in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes

    Wijers-Koster Pauline


    Full Text Available Abstract Background Chondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males. No recurrent chromosomal re-arrangements have so far been observed. Methods: We identified an index case with a balanced translocation by Combined Binary Ratio-Fluorescent in situ Hybridisation (COBRA-FISH karyotyping followed by breakpoint FISH mapping and array-Comparative Genomic Hybridisation (aCGH. Candidate region re-arrangement and candidate gene expression were subsequently investigated by interphase FISH and immunohistochemistry in another 14 cases. Results A balanced t(5;17(p15;q22-23 was identified. In the index case, interphase FISH showed that the translocation was present only in mononucleated cells and was absent in the characteristic multinucleated giant cells. The t(5;17 translocation was not observed in the other cases studied. The breakpoint in 5p15 occurred close to the steroid reductase 5α1 (SRD5A1 gene. Expression of the protein was found in all cases tested. Similar expression was found for the sex steroid signalling-related molecules oestrogen receptor alpha and aromatase, while androgen receptors were only found in isolated cells in a few cases. The breakpoint in 17q22-23 was upstream of the carbonic anhydrase × (CA10 gene region and possibly involved gene-regulatory elements, which was indicated by the lack of CA10 protein expression in the index case. All other cases showed variable levels of CA10 expression, with low expression in three cases. Conclusion We report a novel t(5;17(p15;q22-23 translocation in chondroblastoma without involvement of any of the two chromosomal regions in other cases studied. Our results indicate that the characteristic multinucleated giant cells in chondroblastoma do not have the same clonal origin as the mononuclear population, as they do not harbour the same translocation. We therefore hypothesise that they might be either reactive or

  2. Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.

    Dover, Nir; Barash, Jason R; Burke, Julianne N; Hill, Karen K; Detter, John C; Arnon, Stephen S


    Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types. Infant botulism, an intestinal toxemia orphan disease, is the most common form of human botulism in the United States. It results from swallowed spores of Clostridium botulinum (or rarely, neurotoxigenic Clostridium butyricum or Clostridium baratii) that germinate and temporarily colonize the lumen of the large intestine, where, as vegetative cells, they produce botulinum toxin. Botulinum neurotoxin is encoded by the bont gene that is part of a toxin gene cluster that includes several accessory genes. We sequenced for the first time the complete botulinum neurotoxin gene cluster of nonproteolytic C. baratii type F7. Like the type E and the nonproteolytic type F6 botulinum toxin gene clusters, the C. baratii type F7 had an orfX toxin gene cluster that lacked the regulatory botR gene which is found in proteolytic C. botulinum strains and codes for an alternative σ factor. In the absence of botR, we identified a putative alternative regulatory gene located upstream of the C. baratii type F7 toxin gene cluster. This putative regulatory gene codes for a predicted σ factor that contains DNA-binding-domain homologues to the DNA-binding domains both of BotR and of other members of the TcdR-related group 5 of the σ70 family that are involved in the regulation of toxin gene expression in clostridia. We showed that this TcdR-related protein in association with RNA polymerase core enzyme specifically binds to the C. baratii type F7 botulinum toxin gene cluster promoters. This TcdR-related protein may therefore be involved in regulating the expression of the genes of the botulinum toxin gene cluster in neurotoxigenic C. baratii.

  3. Introduction of a novel 18S rDNA gene arrangement along with distinct ITS region in the saline water microalga Dunaliella.

    Hejazi, Mohammad A; Barzegari, Abolfazl; Gharajeh, Nahid Hosseinzadeh; Hejazi, Mohammad S


    Comparison of 18S rDNA gene sequences is a very promising method for identification and classification of living organisms. Molecular identification and discrimination of different Dunaliella species were carried out based on the size of 18S rDNA gene and, number and position of introns in the gene. Three types of 18S rDNA structure have already been reported: the gene with a size of ~1770 bp lacking any intron, with a size of ~2170 bp consisting one intron near 5' terminus, and with a size of ~2570 bp harbouring two introns near 5' and 3' termini. Hereby, we report a new 18S rDNA gene arrangement in terms of intron localization and nucleotide sequence in a Dunaliella isolated from Iranian salt lakes (ABRIINW-M1/2). PCR amplification with genus-specific primers resulted in production of a ~2170 bp DNA band, which is similar to that of D. salina 18S rDNA gene containing only one intron near 5' terminus. Whilst, sequence composition of the gene revealed the lack of any intron near 5' terminus in our isolate. Furthermore, another alteration was observed due to the presence of a 440 bp DNA fragment near 3' terminus. Accordingly, 18S rDNA gene of the isolate is clearly different from those of D. salina and any other Dunaliella species reported so far. Moreover, analysis of ITS region sequence showed the diversity of this region compared to the previously reported species. 18S rDNA and ITS sequences of our isolate were submitted with accesion numbers of EU678868 and EU927373 in NCBI database, respectively. The optimum growth rate of this isolate occured at the salinity level of 1 M NaCl. The maximum carotenoid content under stress condition of intense light (400 mumol photon m-2 s-1), high salinity (4 M NaCl) and deficiency of nitrate and phosphate nutritions reached to 240 ng/cell after 15 days.

  4. [The biological and anatomical-morphological properties of Hymenolepis diminuta tapeworms of WMS il1 and the WMS "strain"].

    Stradowski, M; Grytner-Ziecina, B; Rebandel, H


    Crowded infrapopulations of H. diminuta obtained from the WMS il1 inbred line resembled those of the potentially non-inbred WMS strain in not showing either the abrupt reductions in the numbers of worms or the destrobilation described by other autors. Denser populations of both types of tapeworm have a greather abundance of 4 - testis proglottids of the 1p3a type (having 1 testis on the poral side and three on the aporal), and fewer of type 0p3a. Changes in the positioning of genital ducts and pores show a marked positive correlation with the abundance of type 2pla proglottids. Strobilae of H. diminuta WMS il1 contain a relatively greather number of type 0p3a proglottids and fewer of type 1p3a, than those of the WMS "strain"; something which is probably linked with the respective selection of the maternal tapeworms.

  5. The dynamics of infection of Tribolium confusum by hymenolepis diminuta: the influence of exposure time and host density.

    Keymer, A


    Survival of Hymenolepis diminuta eggs (as measured by their infectivity to the intermediate host) was found to be age-dependent with an expected value of 11 days when the eggs were retained within the faecal pellet at 10 degree C. The expected life-span of eggs under experimental conditions (i.e. extracted from faecal material and placed on filter paper at 30 degree C) was estimated as 33 min. The mean parasite burden of populations of Tribolium exposed to known densities of H. diminuta eggs was found to rise to a plateau with increasing exposure time. The experimental results provided a method of estimating the instantaneous rate of parasite transmission: a value of 0.0004/egg/min/host/13 cm2 was obtained. The mean parasite burden of populations of T. confusum exposed to known densities of H. diminuta eggs was found to decrease exponentially with increasing host density. A second estimate of the instantaneous rate of parasite transmission of 0.004/egg/min/host/13 cm2 was obtained from the experimental results. No differences in susceptibility to infection between 2-week-old male and female beetles were found. A marked decrease, however, was apparent with increasing beetle age up to 14 weeks post-eclosion.

  6. Replacement by Caenis diminuta walker (ephemeroptera:caenidae) in the mayfly community structure of a thermally-stressed, southeastern stream

    Poff, N L; Matthews, R A


    Mayfly community structure on sycamore and sweetgum leaf packs in a thermally-stressed, post-thermal and an unstressed stream were compared. Leaves were colonized over an 11 wk (77 d) period from December 1982 to March 1983. Degree-days (> 0/sup 0/C) accumulated were 1014, 638 and 627 for the thermally-stressed, post-thermal and unstressed streams, respectively. Significant differences in mayfly community structure were found between the thermally-stressed vs. the post-thermal and unstressed streams with respect to both Stenonema spp. and Caenis diminuta Walker. No significant differences in community structure were found between the two leaf species. Stenonema spp. dominated the mayfly fauna over the sampling period for both the unstressed (68%) and post-thermal (98%) streams; however, C. diminuta replaced Stenonema spp. as the dominant mayfly (88%) within leaf packs from the stream receiving thermal effluent. Additional data suggest C. diminuta is tolerant of rapidly fluctuating thermal regimes ( T of up to 11/sup 0/C in 1 h) and high temperatures (up to 40/sup 0/C). 30 references, 3 figures, 3 tables.

  7. Voluntary Environmental Governance Arrangements

    van der Heijden, J.


    Voluntary environmental governance arrangements have focal attention in studies on environmental policy, regulation and governance. The four major debates in the contemporary literature on voluntary environmental governance arrangements are studied. The literature falls short of sufficiently

  8. Voluntary Environmental Governance Arrangements

    van der Heijden, J.


    Voluntary environmental governance arrangements have focal attention in studies on environmental policy, regulation and governance. The four major debates in the contemporary literature on voluntary environmental governance arrangements are studied. The literature falls short of sufficiently specify

  9. Effect of age of the intermediate host Tribolium confusum (Coleoptera) on infection by Hymenolepis diminuta (Cestoda).

    Shostak, Allen W


    A cross-sectional study of 27 cohorts of Tribolium confusum aged 2-78 wk was done to examine effects of host age on exposure to eggs of Hymenolepis diminuta under standardized conditions. Pre-exposure, fasting, and postexposure mortality were low, sex ratio was equal, and fecundity of hosts was high during the first 30 wk, followed by increasing mortality and male bias of the sex ratio, and declining fecundity, in older beetles. These changes in the host were not associated with pronounced changes in infection results. Prevalence of infection was higher in females than males, but was unaffected by age in both sexes. Intensity of infection was similar between sexes in beetles up to 30 wk old, and thereafter declined in females, but not in males. Age-related changes in hosts were gradual, but unexpected levels of short-term variation in infection results suggest that some undetermined proximate factors may override general host age effects on the infection process.

  10. Cassia alata L: potential role as anthelmintic agent against Hymenolepis diminuta.

    Kundu, Suman; Roy, Saptarshi; Lyndem, Larisha M


    The efficacy of Cassia alata against cestode Hymenolepis diminuta was evaluated in our study. Worms were maintained between rat model and beetle. Air-dried leaves of C. alata were subjected to ethanol extraction. Different concentrations (10-80 mg/ml) of the extract were prepared in phosphate buffer saline and tested on the parasite in vitro. Parasites treated with C. alata showed a decrease in motility with an increase in concentrations and complete immobilization took lesser time compared to control. The paralyzed parasites were further processed for electron microscopic studies. Ultrastructural micrographs revealed swelling of the tegument and blebbing on the tegumental surface throughout the body accompanied with destruction of microtriches and changes such as shrinkage in the scolex region. Depletion of parenchyma cells and destruction in the connective tissues along with sparsely cytoplasmic cytons were also observed, and these observations are similar with worms treated with a known drug praziquantel. These results may suggest that the plant leaves could be considered for controlling helminth infection and can represent a step forward in the search for alternative anthelmintic drug.

  11. Evaluación de una estrategia de conservación para Brevundimonas diminuta

    Nancy Burguet


    Full Text Available Brevundimonas diminuta se reconoce internacionalmente como el microorganismo estándar para las pruebas de reto bacteriano. El Laboratorio de Control de la Calidad de los Laboratorios Liorad dispone de una colección de cepas de referencia donde se encuentra depositada esta cepa, conservada por el método de congelación a -70oC, replicada en el medio de cultivo Caldo Lactosa Salina (CLS. Esta metodología no resultó la más conveniente, por lo que se evaluó otra estrategia de conservación para este microorganismo, donde se empleó el Caldo Triptona Soya como medio de crecimiento, la leche descremada al 20% como sustancia lioprotectora y la liofilización como método de conservación. Para verificar el sustento del cultivo se realizó un adecuado control de la calidad que incluyó la comprobación de pureza y la viabilidad y estabilidad de las propiedades de interés. Los resultados obtenidos durante los 24 meses en que se llevó a cabo el estudio de estabilidad en tiempo real confirmaron que el método elegido brindaría una alternativa y solución al problema relacionado con la conservación de esta cepa.

  12. Conjugative transfer of an IncA/C plasmid-borne blaCMY-2 gene through genetic re-arrangements with an IncX1 plasmid.

    Wiesner, Magdalena; Fernández-Mora, Marcos; Cevallos, Miguel A; Zavala-Alvarado, Crispín; Zaidi, Mussaret B; Calva, Edmundo; Silva, Claudia


    Our observation that in the Mexican Salmonella Typhimurium population none of the ST19 and ST213 strains harbored both the Salmonella virulence plasmid (pSTV) and the prevalent IncA/C plasmid (pA/C) led us to hypothesize that restriction to horizontal transfer of these plasmids existed. We designed a conjugation scheme using ST213 strain YU39 as donor of the blaCMY-2 gene (conferring resistance to ceftriaxone; CRO) carried by pA/C, and two E. coli lab strains (DH5α and HB101) and two Typhimurium ST19 strains (SO1 and LT2) carrying pSTV as recipients. The aim of this study was to determine if the genetic background of the different recipient strains affected the transfer frequencies of pA/C. YU39 was able to transfer CRO resistance, via a novel conjugative mechanism, to all the recipient strains although at low frequencies (10-7 to 10-10). The presence of pSTV in the recipients had little effect on the conjugation frequency. The analysis of the transconjugants showed that three different phenomena were occurring associated to the transfer of blaCMY-2: 1) the co-integration of pA/C and pX1; 2) the transposition of the CMY region from pA/C to pX1; or 3) the rearrangement of pA/C. In addition, the co-lateral mobilization of a small (5 kb) ColE1-like plasmid was observed. The transconjugant plasmids involving pX1 re-arrangements (either via co-integration or ISEcp1-mediated transposition) obtained the capacity to conjugate at very high levels, similar to those found for pX1 (10-1). Two versions of the region containing blaCMY-2 were found to transpose to pX1: the large version was inserted into an intergenic region located where the "genetic load" operons are frequently inserted into pX1, while the short version was inserted into the stbDE operon involved in plasmid addiction system. This is the first study to report the acquisition of an extended spectrum cephalosporin (ESC)-resistance gene by an IncX1 plasmid. We showed that the transfer of the YU39 blaCMY-2 gene

  13. Lead concentrations in Hymenolepis diminuta adults and Taenia taeniaeformis larvae compared to their rat hosts (Rattus norvegicus) sampled from the city of Cairo, Egypt.

    Sures, B; Scheible, T; Bashtar, A R; Taraschewski, H


    Concentrations of lead, determined by electrothermal atomic absorption spectrometry, were compared between the cestodes Hymenolepis diminuta and Taenia taeniaeformis and its host rat (Rattus norvegicus). Rats were sampled at 2 sites, which differed in respect to lead pollution as quantified from road dust, adjacent to the city of Cairo, Egypt. Comparing lead levels among host tissues and the parasites the significantly highest accumulation was found in H. diminuta, followed by rat kidney and larvae of T. taeniaeformis. Calculation of bioconcentration factors showed that H. diminuta contained 36-, 29-, 6- and 6-fold higher lead levels than intestinal wall, liver, kidney and larvae of T. taeniaeformis, at the more polluted site. At the less contaminated site lead bioconcentration factors for H. diminuta were found to be 87, 87 and 11 referred to intestine, liver and kidney of the host. Due to a high variability of the lead concentrations in H. diminuta it was not possible to indicate differences in metal pollution between both sampling sites. This variability may be influenced by different age structures of cestode infrapopulations. It is likely that younger worms contain lower metal levels than older worms due to a shorter exposure period. Thus, it is necessary to standardize the sampling of worms which should be used for indication purposes. Due to a lack of adequate sentinel species in terrestrial habitats more studies are required to validate and standardize the use of helminths as accumulation bioindicators in order to obtain mean values with low standard deviations. The host-parasite system rat-H. diminuta appears to be a useful and promising bioindication system at least for lead in urban ecosystems as rats as well as the tapeworm are globally distributed and easily accessible.

  14. New Data on Human Macrophages Polarization by Hymenolepis diminuta Tapeworm—An In Vitro Study

    Zawistowska-Deniziak, Anna; Basałaj, Katarzyna; Strojny, Barbara; Młocicki, Daniel


    Helminths and their products can suppress the host immune response to escape host defense mechanisms and establish chronic infections. Current studies indicate that macrophages play a key role in the immune response to pathogen invasion. They can be polarized into two distinct phenotypes: M1 and M2. The present paper examines the impact of the adult Hymenolepis diminuta (HD) tapeworm and its excretory/secretory products (ESP) on THP-1 macrophages. Monocytes were differentiated into macrophages and cultured with a living parasite or its ESP. Our findings indicate that HD and ESP have a considerable impact on human THP-1 macrophages. Macrophages treated with parasite ESP (with or without LPS) demonstrated reduced expression of cytokines (i.e., IL-1α, TNFα, TGFβ, IL-10) and chemokines (i.e., IL-8, MIP-1α, RANTES, and IL-1ra), while s-ICAM and CxCL10 expression rose after ESP stimulation. In addition, inflammatory factor expression rose significantly when macrophages were exposed to living parasites. Regarding induced and repressed pathways, significant differences were found between HD and ESP concerning their influence on the phosphorylation of ERK1/2, STAT2, STAT3, AMPKα1, Akt 1/2/3 S473, Hsp60, and Hck. The superior immunosuppressive properties of ESP compared to HD were demonstrated with lower levels of IL-1β, TNF-α, IL-6, IL-23, and IL-12p70 following stimulation. The presence of HD and its ESP were found to stimulate mixed M1/M2 macrophage phenotypes. Our findings indicate new molecular mechanisms involved in the response of human macrophages to tapeworm infection, this could be a valuable tool in understanding the mechanisms underlying the processes of immune regulation during cestodiasis. PMID:28265273

  15. On arrangements of pseudohyperplanes



    To every realizable oriented matroid there corresponds an arrangement of real hyperplanes. The homeomorphism type of the complexified complement of such an arrangement is completely determined by the oriented matroid. In this paper we study arrangements of pseudohyperplanes; they correspond to non-realizable oriented matroids. These arrangements arise as a consequence of the Folkman--Lawrence topological representation theorem. We propose a generalization of the complexification process in this context. In particular we construct a space naturally associated with these pseudo-arrangements which is homeomorphic to the complexified complement in the realizable case. Further, we generalize the classical theorem of Salvetti and show that this space has the homotopy type of a cell complex defined in terms of the oriented matroid.

  16. Clinico-pathology, diagnosis and management of Cysticercus fasciolaris and Hymenolepis diminuta co-infection in wistar rats

    Y. Damodar Singh


    Full Text Available Aim: The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. Materials and Methods: This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats. The dead rats were subjected to thorough post-mortem examination and necropsy samples were processed for hematoxylin and eosin staining for histopathological studies. Faecal samples of live rats were studied for the presence of parasitic eggs. Treatment with anthelmintics was given to manage the mortality and infections. Results: The investigation revealed a natural co-infection of Cysticercus fasciolaris and Hymenolepis diminuta in wistar rats, which were pathogenic enough to cause mortality. Typical lesions associated with the parasites were found in the dead rats. The mortality and infection were managed with common anthelmintics. Conclusion: C. fasciolaris and H. diminuta infection can cause mortality in wistar rats even when individually they cause asymptomatic infection. The mortality and infection can be managed with common anthelmintics.

  17. Response of Flour Beetles to Multiple Stressors of Parasitic (Hymenolepis diminuta), Environmental (Diatomaceous Earth), and Host (Reproduction) Origin.

    Shostak, Allen W; Van Buuren, Kala G; Cook, Ranon


    Organisms face a multitude of potential stressors, and the way these stressors interact can provide insights into underlying biological processes. This study examined the flour beetle Tribolium confusum and its survival, net fecundity, and surface-seeking behavior in response to combinations of stressors from 3 categories. Infection by the cestode Hymenolepis diminuta provided a stress of parasitic origin. Exposure to diatomaceous earth (DE) provided a stress of environmental origin. Use of virgin and mated beetles evaluated reproduction as a stress of host origin. Single and multiple exposure of beetles to parasite eggs achieved a maximum mean abundance of 21 parasites/beetle and a maximum intensity of 90 parasites in an individual beetle. DE reduced initial parasite establishment, but did not directly affect survival of parasites after their establishment in the host. A rehydration technique was used to recover parasites from dead beetles, enabling this to be the first study to correlate H. diminuta intensity at time of death directly to mortality of T. confusum. A dichotomous intensity-mortality relationship was observed in 8% DE, whereby lightly infected (confusum in beetles, the difficulty of achieving high mean abundances, and an apparent need for the stressors to have strong effects individually if they are to have enhanced effects when in combination, suggests that exposure to multiple stressors would seriously impact only a small proportion of the host population.

  18. Shape variation of cysticercoids of Hymenolepis diminuta (Cyclophyllidea) from fed, partially fed, and fasted Tribolium confusum (Coleoptera).

    Shostak, Allen W; Walsh, John G; Wong, Yuen C


    Quantitative studies of a crowding effect on cysticercoids of Hymenolepis diminuta in the intermediate host are few and limited in scope. In this study, we developed a technique to rapidly collect morphological information on large numbers of parasites, and verified the utility of geometric models for simple and accurate estimation of cysticercoid size for quantitative studies. These models were tested using measurements from 4,899 H. diminuta obtained from 666 Tribolium confusum exposed 1-4 wk previously. Length, width, and depth of the body and cercomer (when present) can be used in conjunction with these models to provide the most accurate estimation of parasite size. However, parasite body length alone can be used, with adjustment for effects of host diet and infection intensity, to predict the remaining measurements in incomplete specimens. Parasites that developed in higher intensity infections, or in hosts with reduced food intake, were narrower and had a proportionately shorter cercomer. Host age, sex, and mating status, and parasite age also had statistically significant, but small-magnitude, effects on parasite shape.

  19. Production of nano zinc, zinc sulphide and nanocomplex of magnetite zinc oxide by Brevundimonas diminuta and Pseudomonas stutzeri.

    Mirhendi, Mansoureh; Emtiazi, Giti; Roghanian, Rasoul


    ZnO (Zincite) nanoparticle has many industrial applications and is mostly produced by chemical reactions, usually prepared by decomposition of zinc acetate or hot-injection and heating-up method. Synthesis of semi-conductor nanoparticles such as ZnS (Sphalerite) by ultrasonic was previously reported. In this work, high-zinc tolerant bacteria were isolated and used for nano zinc production. Among all isolated microorganisms, a gram negative bacterium which was identified as Brevundimonas diminuta could construct nano magnetite zinc oxide on bacterial surface with 22 nm in size and nano zinc with 48.29 nm in size. A piece of zinc metal was immersed in medium containing of pure culture of B. diminuta. Subsequently, a yellow-white biofilm was formed which was collected from the surface of zinc. It was dried at room temperature. The isolated biofilm was analysed by X-ray diffractometer. Interestingly, the yield of these particles was higher in the light, with pH 7 at 23°C. To the best of the authors knowledge, this is the first report about the production of nano zinc metal and nano zinc oxide that are stable and have anti-bacterial activities with magnetite property. Also ZnS (sized 12 nm) produced by Pseudomonas stutzeri, was studied by photoluminescence and fluorescent microscope.

  20. Clinico-pathology, diagnosis and management of Cysticercus fasciolaris and Hymenolepis diminuta co-infection in wistar rats

    Singh, Y. Damodar; Arya, Rahul Singh


    Aim: The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. Materials and Methods: This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats. The dead rats were subjected to thorough post-mortem examination and necropsy samples were processed for hematoxylin and eosin staining for histopathological studies. Faecal samples of live rats were studied for the presence of parasitic eggs. Treatment with anthelmintics was given to manage the mortality and infections. Results: The investigation revealed a natural co-infection of Cysticercus fasciolaris and Hymenolepis diminuta in wistar rats, which were pathogenic enough to cause mortality. Typical lesions associated with the parasites were found in the dead rats. The mortality and infection were managed with common anthelmintics. Conclusion: C. fasciolaris and H. diminuta infection can cause mortality in wistar rats even when individually they cause asymptomatic infection. The mortality and infection can be managed with common anthelmintics. PMID:27047007

  1. Optical Arrangement and Method


    Processing of electromagnetic radiation is described, said incoming electromagnetic radiation comprising radiation in a first wavelength interval and a plurality of spatial frequencies. An arrangement comprises a focusing arrangement for focusing the incoming electromagnetic radiation, a first...... cavity configured to comprise an intra cavity laser beam, a nonlinear crystal arranged in the first cavity such that it is capable of receiving the focused electromagnetic radiation and, in dependence on the spatial overlap between the focused electromagnetic radiation and the intra-cavity laser beam......, by interaction with the intra-cavity laser beam provide processed electromagnetic radiation, said processed electromagnetic radiation comprising radiation in a second wavelength interval and at least a subset of said plurality of spatial frequencies. In other words, such an arrangement is capable of enabling...

  2. In vitro and in vivo anthelmintic effects of Caesalpinia bonducella (L.) Roxb. leaf extract on Hymenolepis diminuta (Cestoda) and Syphacia obvelata (Nematoda)

    Gogoi, Shyamalima; Yadav, Arun K.


    Background: Leaves of Caesalpinia bonducella (L.) Roxb. have been traditionally used as an herbal remedy to treat the intestinal helminthic infections in traditional medicine of India. Aim: This study was undertaken to evaluate the potential in vitro and in vivo anthelmintic effects of C. bonducella leaf extract against Syphacia obvelata (Nematoda) and Hymenolepis diminuta (Cestoda). Materials and Methods: The in vitro anthelmintic activity of the extract was investigated on adult worms of S. obvelata (Nematoda) and H. diminuta (Cestoda) in terms of physical motility and mortality of parasites. The in vivo study was performed in H. diminuta-rat model and S. obvelata-mice model, by monitoring the egg per gram of feces count and worm count of animals following the treatment with different doses of plant extract. Results: The study recorded significant and dose-dependent anthelmintic effects of the extract on both the parasites. In the in vitro study, 30 mg/ml concentration of extract caused mortality of H. diminuta in 2.5 ± 0.2 h and S. obvelata in 3.57 ± 0.16 h. In the in vivo study, the extract showed a comparatively better efficacy on S. obvelata, where its 800 mg/kg dose revealed 93% reduction of worm load in mice, as compared to 85% worm load reduction of H. diminuta in rats. Conclusions: The findings suggest that leaf extract of C. bonducella possesses significant anthelmintic effects and supports its use as an anthelmintic in traditional medicine. This appears to be the first report of in vivo anthelmintic activity of C. bonducella against these parasites. PMID:27757275

  3. Characterisation of a large complex intragenic re-arrangement in the FVII gene (F7) avoiding misdiagnosis in inherited factor VII deficiency.

    Giansily-Blaizot, Muriel; Thorel, Delphine; Khau Van Kien, Philippe; Behar, Catherine; Romey, Marie-Catherine; Mugneret, Francine; Schved, Jean-François; Claustres, Mireille


    Inherited factor VII (FVII) deficiency is a rare autosomal recessive bleeding disorder mostly caused by point mutations. Large genomic re-arrangements at F7 locus could account for a fraction of mutant alleles that remain unidentified after DNA sequencing, because they escape conventional polymerase chain reaction (PCR)-based techniques. We report the first systematic screening of F7 for large re-arrangements, by semi-quantitative multiplex PCR of fluorescent fragments targeting the 9 exons and the promoter region. A well-characterised cohort of 43 unrelated patients either apparently homozygous for a F7 point mutation or carrying at least one unidentified F7 mutant allele participated in this study. Two large F7 re-arrangements were identified in two FVII-deficient pedigrees, including a discontinuous deletion involving two distinct portions of F7 whose proximal and distal end junctions were characterised. A simple and efficient method for the routine detection of gross alterations of F7, which accounted for 2.3% of mutant alleles in our sample, is now available in inherited FVII deficiency. This test should complement conventional PCR-based techniques not only in unsolved cases, but also where inheritance pattern analysis is not achievable.

  4. Best connected rectangular arrangements

    Krishnendra Shekhawat


    Full Text Available It can be found quite often in the literature that many well-known architects have employed either the golden rectangle or the Fibonacci rectangle in their works. On contrary, it is rare to find any specific reason for using them so often. Recently, Shekhawat (2015 proved that the golden rectangle and the Fibonacci rectangle are one of the best connected rectangular arrangements and this may be one of the reasons for their high presence in architectural designs. In this work we present an algorithm that generates n-4 best connected rectangular arrangements so that the proposed solutions can be further used by architects for their designs.

  5. A behavioral study of the beetle Tenebrio molitor infected with cysticercoids of the rat tapeworm Hymenolepis diminuta

    Sheiman, I. M.; Shkutin, M. F.; Terenina, N. B.; Gustafsson, M. K. S.


    The host-parasite relationship, Tenebrio molitor- Hymenolepis diminuta, was analyzed. The learning behavior of infected and uninfected (control) beetles in a T-maze was compared. The infected beetles moved much slower in the T-maze than the controls. The infected beetles reached the same level of learning as the controls. However, they needed more trials than the controls. The effect of the infection was already distinct after the first week and even higher after the second week. This indicates that the initial phase of infection caused stress in the beetles. Longer infection did not worsen their ability to learn. Thus, the parasites clearly changed the behavior of their intermediate host and probably made them more susceptible to their final host, the rat.

  6. Power distribution arrangement


    An arrangement and a method for distributing power supplied by a power source to two or more of loads (e.g., electrical vehicular systems) is disclosed, where a representation of the power taken by a particular one of the loads from the source is measured. The measured representation of the amount...

  7. Intermediate links of line arrangements

    Bodin, Arnaud


    We investigate several topological properties of line arrangements. The first result is that two generic complex line arrangements are equivalent. In fact for a line arrangement A we associate its defining polynomial f= prod_i (a_ix+b_iy+c_i), so that A = (f=0). We even prove that the defining polynomials of two generic line arrangements are topologically equivalent. In higher dimension the related result is that within a family of equivalent hyperplane arrangements the defining polynomials are topologically equivalent. A second type of objects associated to a line arrangement are links A cap S^3_r(0) obtained by intersecting the arrangement with some spheres. Several topics are discussed: (a) some link configurations can be realized by complex line arrangements but not by real line arrangements; (b) if we intersect the arrangements with a vertical band instead of a sphere, what link configurations can be obtained? (c) relations between link configurations obtained by bands and spheres.

  8. Imaging arrangement and microscope

    Pertsinidis, Alexandros; Chu, Steven


    An embodiment of the present invention is an imaging arrangement that includes imaging optics, a fiducial light source, and a control system. In operation, the imaging optics separate light into first and second tight by wavelength and project the first and second light onto first and second areas within first and second detector regions, respectively. The imaging optics separate fiducial light from the fiducial light source into first and second fiducial light and project the first and second fiducial light onto third and fourth areas within the first and second detector regions, respectively. The control system adjusts alignment of the imaging optics so that the first and second fiducial light projected onto the first and second detector regions maintain relatively constant positions within the first and second detector regions, respectively. Another embodiment of the present invention is a microscope that includes the imaging arrangement.

  9. Steerable catoptric arrangements

    Rambauske, W.R.


    Catoptric arrangements for steering a laser beam by moving one, or more, mirrors relative to two substantially orthogonal axis of rotation are shown. In the various embodiments illustrated, one of such axes of rotation, around which all of the mirrors in each embodiment are rotatable, is coincident with the longitudinal axis of the laser beam to be steered so as to direct such longitudinal axis toward different points on a first focal circle. Means are provided to rotate all of the mirrors in each embodiment, except the mirror irradiated by the laser beam to be steered, around the second axis of rotation to direct the longitudinal axis of such beam toward different points on a second focal circle substantially orthogonal to the first focal circle. Also shown are exemplary modifications to position the mirrors within each arrangement to aim the steered beam to points adjacent to the first and second focal circles.

  10. Hyperplane arrangements an introduction

    Dimca, Alexandru


    This textbook provides an accessible introduction to the rich and beautiful area of hyperplane arrangement theory, where discrete mathematics, in the form of combinatorics and arithmetic, meets continuous mathematics, in the form of the topology and Hodge theory of complex algebraic varieties. The topics discussed in this book range from elementary combinatorics and discrete geometry to more advanced material on mixed Hodge structures, logarithmic connections and Milnor fibrations. The author covers a lot of ground in a relatively short amount of space, with a focus on defining concepts carefully and giving proofs of theorems in detail where needed. Including a number of surprising results and tantalizing open problems, this timely book also serves to acquaint the reader with the rapidly expanding literature on the subject. Hyperplane Arrangements will be particularly useful to graduate students and researchers who are interested in algebraic geometry or algebraic topology. The book contains numerous exercise...

  11. Coloring and Guarding Arrangements

    Bose, Prosenjit; Collette, Sébastien; Hurtado, Ferran; Korman, Matias; Langerman, Stefan; Taslakian, Perouz


    Given an arrangement of lines in the plane, what is the minimum number $c$ of colors required to color the lines so that no cell of the arrangement is monochromatic? In this paper we give bounds on the number c both for the above question, as well as some of its variations. We redefine these problems as geometric hypergraph coloring problems. If we define $\\Hlinecell$ as the hypergraph where vertices are lines and edges represent cells of the arrangement, the answer to the above question is equal to the chromatic number of this hypergraph. We prove that this chromatic number is between $\\Omega (\\log n / \\log\\log n)$. and $O(\\sqrt{n})$. Similarly, we give bounds on the minimum size of a subset $S$ of the intersections of the lines in $\\mathcal{A}$ such that every cell is bounded by at least one of the vertices in $S$. This may be seen as a problem on guarding cells with vertices when the lines act as obstacles. The problem can also be defined as the minimum vertex cover problem in the hypergraph $\\Hvertexcell$...

  12. Evidence that the factor used by the tapeworm, Hymenolepis diminuta, to direct the foraging of its intermediate host, Tribolium confusum, is a volatile attractant.

    Evans, W S; Wong, A; Hardy, M; Currie, R W; Vanderwel, D


    We have previously demonstrated that flour beetles, Tribolium confusum, are more attracted to the feces from rats with patent Hymenolepis diminuta infections than to feces from uninfected rats. The objective of this study was to determine if this effect is due to a volatile attractant. Volatile substances emitted by feces from H. diminuta-infected rats or from uninfected controls were collected by aspirating fresh rat feces, while trapping the volatiles on Porapak Q (a solid adsorbant). The volatiles were eluted from the Porapak Q with diethyl ether, and the relative attractancy of the volatiles to prestarved beetles was assessed by bioassay. More beetles were attracted to volatiles of feces from infected rats than to volatiles of feces from uninfected controls (Pconfusum) through the use of attractive, volatile material released from the feces of its definitive host.

  13. Evidence for grow-through penetration of 0.2-μm-pore-size filters by Serratia marcescens and Brevundimonas diminuta.

    Kaushal, Simran; Gervais, Brandi; Lute, Scott; Eroraha, Ajiri; Faustino, Patrick; Brorson, Kurt; Hussong, David


    We find that both Brevundimonas diminuta and Serratia marcescens can grow through sterilizing grade filter membranes of different membrane polymer compositions. Although this passage does not occur on a consistent basis, generation of "grow-through positive" results indicate that grow-through can occur stochastically at basal levels. This observation argues that the following risk mitigation strategies during pharmaceutical aseptic processing are warranted: minimization of processing times, and monitoring, minimizing and characterizing pre-filter bioburden.

  14. First isolation of two colistin-resistant emerging pathogens, Brevundimonas diminuta and Ochrobactrum anthropi, in a woman with cystic fibrosis: a case report


    Abstract Introduction Cystic fibrosis afflicted lungs support the growth of many bacteria rarely implicated in other cases of human infections. Case presentation We report the isolation and identification, by 16S rRNA amplification and sequencing, of two emerging pathogens resistant to colistin, Brevundimonas diminuta and Ochrobactrum anthropi, in a 17-year-old woman with cystic fibrosis and pneumonia. The patient eventually responded well to a 2-week regime of imipenem and tobramycin. Conclu...

  15. Hymenolepis nana: immunity against oncosphere challenge in mice previously given viable or non-viable oncospheres of H. nana, H. diminuta, H. microstoma and Taenia taeniaeformis.

    Ito, A; Onitake, K; Sasaki, J; Takami, T


    When mice, previously given oral inoculation with viable oncospheres of the heterologous cestode species (Hymenolepis diminuta, H. microstoma, Taenia taeniaeformis) and the homologous one (H. nana), were challenged with oncospheres of H. nana 4 days after the primary inoculation, they showed strong and complete resistance to H. nana challenge, respectively. However, the resistance was not evoked in mice given either infective eggs of Toxocara canis or non-viable oncospheres of all cestode species examined. Congenitally athymic nude mice given viable oncospheres did not show any resistance to H. nana either. Eosinophil infiltration around cysticercoids of H. nana in the intestinal villi appeared to be more prominent in mice previously given viable oncospheres of H. diminuta than in mice given non-viable oncospheres or PBS only. Some of the eosinophils in the villus harboring cysticercoid(s) of H. nana invaded the epithelia in the former, whereas all eosinophils remained in the lamina propria in the latter. There was almost no eosinophil infiltration in nude mice. Microscopic observations revealed that oncospheres of H. diminuta, which require beetles as the intermediate host like H. microstoma, could invade the mouse intestinal tissue. Therefore, it is strongly suggested that the strong cross resistance to H. nana in mice, induced by oncospheres of all heterologous cestode species, is thymus-dependent and due to oncospheral invasion into the intestinal tissue of mice.

  16. Trichinella spiralis mtDNA: a nematode mitochondrial genome that encodes a putative ATP8 and normally structured tRNAS and has a gene arrangement relatable to those of coelomate metazoans.

    Lavrov, D V; Brown, W M


    The complete mitochondrial DNA (mtDNA) of the nematode Trichinella spiralis has been amplified in four overlapping fragments and 16,656 bp of its sequence has been determined. This sequence contains the 37 genes typical of metazoan mtDNAs, including a putative atp8, which is absent from all other nematode mtDNAs examined. The genes are transcribed from both mtDNA strands and have an arrangement relatable to those of coelomate metazoans, but not to those of secernentean nematodes. All protein genes appear to initiate with ATN codons, typical for metazoans. Neither TTG nor GTT start codons, inferred for several genes of other nematodes, were found. The 22 T. spiralis tRNA genes fall into three categories: (i) those with the potential to form conventional "cloverleaf" secondary structures, (ii) those with TPsiC arm + variable arm replacement loops, and (iii) those with DHU-arm replacement loops. Mt-tRNA(R) has a 5'-UCG-3' anticodon, as in most other metazoans, instead of the very unusual 5'-ACG-3' present in the secernentean nematodes. The sequence also contains a large repeat region that is polymorphic in size at the population and/or individual level. PMID:11156984

  17. Auspicious tatami mat arrangements

    Erickson, Alejandro; Schurch, Mark; Woodcock, Jennifer


    An \\emph{auspicious tatami mat arrangement} is a tiling of a rectilinear region with two types of tiles, $1 \\times 2$ tiles (dimers) and $1 \\times 1$ tiles (monomers). The tiles must cover the region and satisfy the constraint that no four corners of the tiles meet; such tilings are called \\emph{tatami tilings}. The main focus of this paper is when the rectilinear region is a rectangle. We provide a structural characterization of rectangular tatami tilings and use it to prove that the tiling is completely determined by the tiles that are on its border. We prove that the number of tatami tilings of an $n \\times n$ square with $n$ monomers is $n2^{n-1}$. We also show that, for fixed-height, the generating function for the number of tatami tilings of a rectangle is a rational function, and outline an algorithm that produces the generating function.

  18. Sequential and concurrent exposure of flour beetles ( Tribolium confusum ) to tapeworms ( Hymenolepis diminuta ) and pesticide (diatomaceous earth).

    Shostak, Allen W


    The response of Tribolium confusum to sublethal levels of 2 environmental stressors was studied, i.e., parasitic infection represented by the cestode Hymenolepis diminuta , and a physical stressor represented by the natural pesticide diatomaceous earth (DE). These were applied sequentially (DE, then infection) to detect indirect or carryover effects of DE, and concurrently (DE applied immediately after exposure to parasites and DE presence maintained throughout the infection) to detect direct effects of DE. DE alone, but not parasitism alone, produced significant host mortality, and concurrent treatment with DE and parasitism did not increase mortality over DE alone. Parasite abundance was significantly higher following sequential, but not concurrent, DE exposure. Parasite abundance in mated hosts was significantly higher than in virgin hosts. Parasitic infection resulted in significantly fewer eggs retained in the oviduct of beetles, but there was no difference in the number of eggs that accumulated in the culture medium and no difference in the surface-seeking behavior of beetles. Mating status of beetles in all treatments, and DE exposure in concurrent treatments significantly increased their surface-seeking behavior. Concurrent exposure to DE also resulted in a 4- to 6-fold increase in host egg numbers that accumulated in the culture medium. Although DE exposure increased parasite numbers in the beetles, these 2 stressors otherwise appeared to act independently.

  19. An unusual gene arrangement for the putative chromosome replication origin and circadian expression of dnaN in Synechococcus sp. strain PCC 7942.

    Liu, Y; Tsinoremas, N F


    In eubacteria, the clustering of DnaA boxes around the dnaN (beta subunit of DNA polymerase III) and dnaA genes usually defines the chromosome replication origin (oriC). In this study, the dnaN locus from the cyanobacterium Synechococcus sp. strain PCC 7942 was sequenced. The gene order in this region is cbbZp-dnaN-orf288-purL-purF which contrasts with other eubacteria. A cluster of eleven DnaA boxes (consensus sequence: TTTTCCACA) was found in the intergenic region between dnaN and cbbZp. We also found a 41-bp sequence within this region that is 80% identical to the proposed oriC of Streptomyces coelicolor. Therefore, we propose that this intergenic region may serve as an oriC in Synechococcus. Using bacterial luciferase as a reporter, we also showed that dnaN is rhythmically expressed, suggesting that DNA replication could be under circadian control in this organism.

  20. Chloroplast genome sequence of the moss Tortula ruralis: gene content, polymorphism, and structural arrangement relative to other green plant chloroplast genomes

    Wolf Paul G


    Full Text Available Abstract Background Tortula ruralis, a widely distributed species in the moss family Pottiaceae, is increasingly used as a model organism for the study of desiccation tolerance and mechanisms of cellular repair. In this paper, we present the chloroplast genome sequence of T. ruralis, only the second published chloroplast genome for a moss, and the first for a vegetatively desiccation-tolerant plant. Results The Tortula chloroplast genome is ~123,500 bp, and differs in a number of ways from that of Physcomitrella patens, the first published moss chloroplast genome. For example, Tortula lacks the ~71 kb inversion found in the large single copy region of the Physcomitrella genome and other members of the Funariales. Also, the Tortula chloroplast genome lacks petN, a gene found in all known land plant plastid genomes. In addition, an unusual case of nucleotide polymorphism was discovered. Conclusions Although the chloroplast genome of Tortula ruralis differs from that of the only other sequenced moss, Physcomitrella patens, we have yet to determine the biological significance of the differences. The polymorphisms we have uncovered in the sequencing of the genome offer a rare possibility (for mosses of the generation of DNA markers for fine-level phylogenetic studies, or to investigate individual variation within populations.

  1. First isolation of two colistin-resistant emerging pathogens, Brevundimonas diminuta and Ochrobactrum anthropi, in a woman with cystic fibrosis: a case report

    Menuet Magalie


    Full Text Available Abstract Introduction Cystic fibrosis afflicted lungs support the growth of many bacteria rarely implicated in other cases of human infections. Case presentation We report the isolation and identification, by 16S rRNA amplification and sequencing, of two emerging pathogens resistant to colistin, Brevundimonas diminuta and Ochrobactrum anthropi, in a 17-year-old woman with cystic fibrosis and pneumonia. The patient eventually responded well to a 2-week regime of imipenem and tobramycin. Conclusion Our results clearly re-emphasize the emergence of new colistin-resistant pathogens in patients with cystic fibrosis.

  2. [Influence of the selection of maternal Hymenolepis diminuta WMS il1 on the variability of descended tapeworms].

    Stradowski, Marek


    A continuation of a single-individual culture of Hymenolepis diminuta WMS ill from generations 37 to 66 revealed a very high infective ability of cysticercoids which is reflected in the percentage of tapeworms detected in relation to the number of cysticercoids given to rats (94.4%). The tapeworms investigated revealed a significant increase in the abundance of type 0p3a proglottids (those with no testes on the poral side and 3 on the aporal) in tapeworms of successive generation groups. Each group of tapeworms analysed statistically belonged to three successive generations and numbered 31-34 individuals. The mean abundances of 0p3a type proglottids in tapeworms of the first groups studied in experiment, including generations 37-39 and 40-42 were 9.2% and 9.5%, respectively. The last studied groups, including generations 61-63 and 64-66 had higher mean numbers of type 0p3a proglottids, at 11.1% and 11.5%, respectively. The quantitative figures of 1p3a type proglottids amounted to 1.6% and 1.3% in first generation groups and in the last two groups 0.8% and 1.0%, respectively. The probable cause of this significant (P < 0.01) relative increase in the numbers of 0p3a type proglottids and decrease (P < 0.01) in the numbers of 1p3a type proglottids was the deliberate selection of maternal tapeworms characterized by numbers of 0p3a type proglottids greater and 1p3a type proglottids smaller than the average for their generation.

  3. Applications of Plackett–Burman and Central Composite Design for the Optimization of Novel Brevundimonas diminuta KT277492 Chitinase Production, Investigation of its Antifungal Activity

    E. Ashour Warda

    Full Text Available ABSTRACT Biological control strategy which can damage chitin, a vital component of pathogenic fungi and arthropods promises a safe solution for many fungal problems. And it’s more favorable than chemicals which increase health risks and environmental problems. Thus, the chitinase producers appear potential candidates of biological control of pathogenic fungi. Brevundimonus diminuta KT277492 is a new isolate that has been isolated recently from Egyptian soil. Significant factors that affecting the chitinase enzyme production were studied and optimized using Plackett-Burman and Response Surface Methodology (RSM. As a result, maximum production of chitinase enzyme was 832.87 IUL-1, this result presented about 8.767-fold increase in the enzyme production. In the last phase of the study, partially purified chitinase enzyme obtained from B. diminuta KT277492 was tested against two pathogenic fungi and the results showed good inhibitory activity against A. alternata and F. solani with IZD of 31±0.25 and 25±0.91 mm respectively. Finally, obtained results indicated the value of optimization process and the optimized chitinase enzyme could be an excellent choice in application of food and biotechnology as a biofungicide. This reflects the necessity of studying the characteristics and kinetics of the enzyme in the forthcoming study.

  4. Application of Glomus sp. and Pseudomonas diminuta Reduce the Use of Chemical Fertilizers in Production of Potato Grown on Different Soil Types

    Nurbaity, A.; Sofyan, E. T.; Hamdani, J. S.


    The use of high chemical fertilizer rates in potato production has been applied on the farm in Indonesia. Application of biofertilizer consists of arbuscular mycorrhizal fungi has been tested to reduce the use of NPK rates in production of potato and to determine whether different soil types will have different response to this biofertilizer. A greenhouse experiment was conducted using mixtures of spores of Glomus sp. and inoculant of mycorrhizal helper bacteria Pseudomonas diminuta, applied at different rates of NPK fertilizer (0, 25, 50, 75 and 100% of recommended rates) and different soil types (Andisols and Inceptisols). Results of experiment showed that application of Glomus sp. and P. diminuta reduced the use of NPK up to 50%, where the growth (plant height and tuber number), N,P,K uptake and tuber yields of potato had similar effect to the highest recommendation rate of NPK fertilizer. Inceptisols in general had better response to the biofertiliser compared to Andisols. Findings from this experiment confirmed the evidences that biofertilizer could reduce the use of chemical fertilizer, and the widely distributed soil in Indonesia such as Inceptisols, is potential to be used as a medium for potato production.

  5. Floral arrangements and hummingbird feeding.

    Hainsworth, F Reed; Mercier, Theresa; Wolf, Larry L


    The influence of simulated inflorescence design on feeding behavior of 3 male Eugenes fulgens (Rivoli's hummingbird) and one female Lampornis clemenciae (Bluethroated hummingbird) was studied in the laboratory using artificial flowers. Five two-dimensional and three three-dimensional arrangements provided constant rewards per artificial flower. Visits to two-dimensional arrangements had more flower visits per feeding bout, proportionally more flower revisits, and shorter time between flowers than visits to three-dimensional arrangements. This suggests inflorescence design may influence pollen movement by hummingbirds.

  6. "Fraud alert": joint venture arrangements.

    Vipperman, R M


    The Office of Inspector General of the Department of Health and Human Services recently issued a special "Fraud Alert" identifying those characteristics of joint venture arrangements that it views as indicators of potentially unlawful activity. As discussed in this article, participants in joint ventures should examine their arrangements to see if one or more of the questionable features are present, and, if so, should take steps to eliminate them, to the extent possible.

  7. Arranged marriages annulled by law.

    Zhu, H


    The arranged marriages of 210 young people in Yongle Town in Zunyi County of Guizhou Province were dissolved in 1995. The proportion of child betrothals, which generally happens among close relatives, is as high as 85% in the town. Some engagements, known as fetus betrothals or belt betrothals, are arranged before the children are born or while they are still infants strapped (belted) to their mothers. Dissemination of information from the Constitution, the Marriage Law, and the Regulations on the Registration of Marriage concerning marriage, healthier births, and good upbringing of children, and other information on reproductive health, has shown young people that they have the freedom to love and marry of their own free will, that their marriage is protected by law, and that consanguineous marriage is harmful to the health of future generations. Some convinced their parents that their arranged marriages should be annulled.

  8. Manipulating Multistage Interconnection Networks Using Fundamental Arrangements

    E. Gur


    Full Text Available Optimizing interconnection networks is a prime object in switching schemes. In this work the authors present a novel approach for obtaining a required channel arrangement in a multi-stage interconnectionnetwork, using a new concept – a fundamental arrangement. The fundamental arrangement is an initial N-1 stage switch arrangement that allows obtaining any required output channel arrangement given an input arrangement, using N/2 binary switches at each stage. The paper demonstrates how a fundamental arrangement can be achieved and how, once this is done, any required arrangement may be obtained within 2(N-1 steps.

  9. Anthelmintic effects of Oroxylum indicum stem bark extract on juvenile and adult stages of Hymenolepis diminuta (Cestoda), an in vitro and in vivo study.

    Deori, Khirod; Yadav, Arun K


    Worldwide, traditional usage of herbal medicines is a common practice to treat various parasitic infections. In India, bark decoction of Oroxylum indicum (L.) Kurz. (Bignoniaceae) is used as a traditional medicine to cure intestinal-helminthic infections. This study investigated the anthelmintic efficacy of methanolic bark extract of O. indicum on Hymenolepis diminuta (Cestoda), using both in vitro and in vivo methods. Utilizing a mini-questionnaire, first, we collected information about the pattern of anthelmintic use of this plant. Later, in vitro efficacy of extract was tested at 10, 20 and 30 mg/ml on both the artificially excysted juveniles and adult H. diminuta worms. Herein, scanning electron microscopy (SEM) was also utilized to determine the possible effects of extract on tegumental surfaces of juvenile and adult cestode. In vivo, extract was tested at 250, 500 and 1000 mg/kg in H. diminuta albino rat model, against juvenile and adult cestode. Praziquantel (PZQ) served as reference drug in anthelmintic assays. The acute toxicity of extract was determined as per the OECD guidelines. The field questionnaire data revealed that 78 % of people in the area use O. indicum stem bark against intestinal helminths, and of these, 75 % of people also believed it highly efficacious anthelmintic remedy. In vitro testing of extract revealed significant effects on juvenile worms, and 30 mg/ml of extract caused mortality of juveniles at the initial period (0.25 ± 0.00 h). Conversely, PZQ (1 mg/ml) showed paralysis and mortality of juvenile cestodes in 0.44 ± 0.04 and 1.11 ± 0.06 h, respectively. As determined by SEM, in vitro exposure to extract showed substantial effects on both juveniles and adult worms in the form of wrinkled scolex, distorted tegument and eroded microtriches. In vivo study revealed better efficacy of extract against juveniles than adult stages of parasite. Treatment of rats with 1000 mg/kg of extract caused 79.3 % reduction in EPG counts

  10. Sex differences in frass production and weight change in Tenebrio molitor (Coleoptera) infected with cysticercoids of the tapeworm Hymenolepis diminuta (Cestoda)

    Shea, John F.


    In their intermediate host, parasites alter aspects of host physiology including waste production and body weight. Further, this alteration may differ between female and male hosts. To study this, a beetle (Tenebrio molitor)-tapeworm (Hymenolepis diminuta) system was used. Infected and uninfected male and female beetles were individually housed in vials without food. Each beetle's weight change and frass production were measured over 24 h periods at 3, 7, 12 and 16 days post-infection. Treatment (infection) had no effect on weight change, but males lost more weight than females. Further, infected females produced more frass than control females. Males on the day of infection had a higher food intake than females. These results suggest that males will be more exposed to infection than females and could explain why males had a higher median cysticercoid infection level. PMID:17119613

  11. Fine-scale analysis of parasite resistance genes in the red flour beetle, Tribolium castaneum.

    Zhong, Daibin; Pai, Aditi; Wang, Mei-Hui; Keech, Naomi; Yan, Guiyun


    Parasite infection impacts population dynamics through effects on fitness and fecundity of the individual host. In addition to the known roles of environmental factors, host susceptibility to parasites has a genetic basis that has not been well characterized. We previously mapped quantitative trait loci (QTL) for susceptibility to rat tapeworm (Hymenolepis diminuta) infection in Tribolium castaneum using dominant AFLP markers; however, the resistance genes were not identified. Here, we refined the QTL locations and increased the marker density in the QTL regions using new microsatellite markers, sequence-tagged site markers, and single-strand conformational polymorphism markers. Resistance QTL in three linkage groups (LG3, LG6, and LG8) were each mapped to intervals castaneum resistance to H. diminuta infection.

  12. Moduli of weighted hyperplane arrangements

    Lahoz, Martí; Macrí, Emanuele; Stellari, Paolo


    This book focuses on a large class of geometric objects in moduli theory and provides explicit computations to investigate their families. Concrete examples are developed that take advantage of the intricate interplay between Algebraic Geometry and Combinatorics. Compactifications of moduli spaces play a crucial role in Number Theory, String Theory, and Quantum Field Theory – to mention just a few. In particular, the notion of compactification of moduli spaces has been crucial for solving various open problems and long-standing conjectures. Further, the book reports on compactification techniques for moduli spaces in a large class where computations are possible, namely that of weighted stable hyperplane arrangements.

  13. 42 CFR 413.241 - Pharmacy arrangements.


    ... 42 Public Health 2 2010-10-01 2010-10-01 false Pharmacy arrangements. 413.241 Section 413.241... Disease (ESRD) Services and Organ Procurement Costs § 413.241 Pharmacy arrangements. Effective January 1, 2011, an ESRD facility that enters into an arrangement with a pharmacy to furnish renal dialysis...

  14. Free arrangements and coefficients of characteristic polynomials

    Abe, Takuro


    Ziegler showed that free arrangements have free restricted multiarrangements (multirestrictions). After Ziegler's work, several results concerning "reverse direction", namely characterizing freeness of an arrangement via that of multirestriction, have appeared. In this paper, we prove that the second Betti number of the arrangement plays a crucial role.

  15. 45 CFR 302.34 - Cooperative arrangements.


    ... PLAN REQUIREMENTS § 302.34 Cooperative arrangements. The State plan shall provide that the State will enter into written agreements for cooperative arrangements under § 303.107 with appropriate courts, law... 45 Public Welfare 2 2010-10-01 2010-10-01 false Cooperative arrangements. 302.34 Section...


    Chernyshov Alexander V.


    Full Text Available The music-compositional principles of commercial and political advertising and also the self-promotion of electronic media (radio, television, Internet are considered in this mediatext: from the elementary beeps, symbolic functions, emblems/logos and musical brands to the sound engineering technology to underscore the product's name and the complex synthesis between music and intra movements and color-light design of frames. Simultaneously examines, how the musical arrangement of ethereal advertising is involved in creation the emotional drama or bravado which reach the level of explicit or associative counterpoint 'music with the advertised object or subject' and which extend to expression of cultural image of all the broadcast channel. The article explores the works of the next genres like infomercial, teleshopping, film-ad, and autonomous commercials that have been produced in European countries or USA.

  17. The physics of custody arrangements

    Gomberoff, Andrés; Romagnoli, Pierre Paul


    Divorced individuals face complex situations when they have children with different ex-partners, or even more, when their new partners have children of their own. In such cases, and when kids spend every other weekend with each parent, a practical problem emerges: Is it possible to have such a custody arrangement that every couple has either all of the kids together or no kids at all? We show that in general, it is not possible, but that the number of couples that do can be maximized. The problem turns out to be equivalent to finding the ground state of a spin glass system, which is known to be equivalent to what is called a weighted max-cut problem in graph theory, and hence it is NP-Complete.

  18. Manipulation of host food availability and use of multiple exposures to assess the crowding effect on Hymenolepis diminuta in Tribolium confusum.

    Shostak, A W; Walsh, J G; Wong, Y C


    We studied the 'crowding effect' in Tribolium confusum infected with Hymenolepis diminuta. Manipulations included age and number of parasites, and diet, sex, age and number of exposures of hosts. Volume per parasite was unaffected until an intensity of at least 5-10 parasites per host, then declined approximately inversely as intensities increased. Parasite size was affected by host sex but not age or reproductive status. Host diet affected parasite size and the impact of crowding. Daily gain in parasite volume peaked partway through the developmental period and preceded the first evidence of a crowding effect. Parasites that established during a second exposure had a transient developmental delay but eventually grew as large or larger than parasites from a single exposure with the same total intensity. Parasites responded to crowding by differential allocation of resources. Cercomer volume decreased even with slight crowding, the capsule surrounding the scolex was not reduced until crowding became more severe, and scolex width was reduced only in the most extreme conditions. The data support the hypothesis that the crowding effect in this system is driven primarily by nutrient, rather than space limitations.

  19. Algorithms for Optimally Arranging Multicore Memory Structures

    Wei-Che Tseng


    Full Text Available As more processing cores are added to embedded systems processors, the relationships between cores and memories have more influence on the energy consumption of the processor. In this paper, we conduct fundamental research to explore the effects of memory sharing on energy in a multicore processor. We study the Memory Arrangement (MA Problem. We prove that the general case of MA is NP-complete. We present an optimal algorithm for solving linear MA and optimal and heuristic algorithms for solving rectangular MA. On average, we can produce arrangements that consume 49% less energy than an all shared memory arrangement and 14% less energy than an all private memory arrangement for randomly generated instances. For DSP benchmarks, we can produce arrangements that, on average, consume 20% less energy than an all shared memory arrangement and 27% less energy than an all private memory arrangement.

  20. Flexible Working Time Arrangements in Bulgaria

    Beleva, Iskra


    The objective of this paper is to analyze the flexible working time arrangements in Bulgaria, using a life-course perspective. Two important features have to be outlined, namely: underdeveloped flexible forms of employment in the country, including working time arrangement, and lack of previous analysis on flexible working time arrangements from the angle of life-course perspective. The author describes the regulatory framework, collective agreements at national and company level as a frame w...

  1. Living Arrangements of Young Adults in Europe

    Katrin Schwanitz


    Full Text Available Comparative research suggests that there are great cross-national and cross-temporal differences in living arrangements of young adults aged 18-34 in Europe. In this paper, we examine young adults’ living arrangements (1 across several European countries and different national contexts, and (2 by taking into account cross-time variability. In doing so, we pay careful attention to a comprehensive conceptualisation of living arrangements (including extended and non-family living arrangements. The aim of this paper is to deepen our understanding of family structure and household arrangements in Europe by examining and mapping the cross-national and cross-temporal variety of young adults’ living arrangements. For our analysis we use data from the Integrated Public Use Microdata Series International (IPUMSi for the census rounds 1980, 1990, and 2000 for eight European countries (Austria, France, Greece, Hungary, Ireland, Portugal, Romania, and Switzerland. We employ log-linear models to ascertain the influence of individual and contextual factors on living arrangements. The analyses lend further support to a North/West – South/East divide in living arrangements and general gender differentials in extended family living. Other interesting results are the heterogeneity in the living arrangements of single mothers across geographic areas, and the upward trend of extended household living for young men and women between 1980 and 2000.

  2. Specific cross-immunity between Hymenolepis nana and H. diminuta: effects of transfer of immunity with homologous and heterologous immune mesenteric lymph node cells in BALB/c mice.

    Palmas, C; Ecca, A R; Gabriele, F


    In BALB/c mice, Hymenolepis nana and H. diminuta stimulate a strong response. Accelerated expulsion of adult worms, as well as protection against larvae, occurred anamnestically when homologous or heterologous mesenteric lymph node cells from immune mice were transferred before challenge. The results further support the hypothesis that worm expulsion is a thymus dependent phenomenon. The extensive cross reactivity found is discussed in relation to the distinctive characteristics of the two worms. These results strongly suggest that there are antigenic similarities between the two parasites and that the accelerated expulsion of heterologous challenge infections is the result of a specific response to shared antigens.

  3. Hyperbolic structures on a toric arrangement complement

    Shen, Dali


    This thesis studies the geometric structures on toric arrangement complements. Inspired by the special hypergeometric functions associated with a root system, we consider a family of connections on a total space which is the product of the complement of a toric arrangement (=finite union of hypertor

  4. Encoding and Decoding Procedures for Arrangements

    Alexander A. Babaev


    Full Text Available This article discusses an algorithm based on the encoding procedure for representing a set of arrangement elements as a single number. Also the author provides the procedure for the inverse transformation of the code into arrangement elements. In addition the Article includes recommendations on the use of the above procedures in combinatorial algorithms of optimization.

  5. Cooling arrangement for a tapered turbine blade

    Liang, George


    A cooling arrangement (11) for a highly tapered gas turbine blade (10). The cooling arrangement (11) includes a pair of parallel triple-pass serpentine cooling circuits (80,82) formed in an inner radial portion (50) of the blade, and a respective pair of single radial channel cooling circuits (84,86) formed in an outer radial portion (52) of the blade (10), with each single radial channel receiving the cooling fluid discharged from a respective one of the triple-pass serpentine cooling circuit. The cooling arrangement advantageously provides a higher degree of cooling to the most highly stressed radially inner portion of the blade, while providing a lower degree of cooling to the less highly stressed radially outer portion of the blade. The cooling arrangement can be implemented with known casting techniques, thereby facilitating its use on highly tapered, highly twisted Row 4 industrial gas turbine blades that could not be cooled with prior art cooling arrangements.

  6. Exchange rate arrangements: From extreme to "normal"

    Beker Emilija


    Full Text Available The paper studies theoretical and empirical location dispersion of exchange rate arrangements - rigid-intermediate-flexible regimes, in the context of extreme arrangements of a currency board, dollarization and monetary union moderate characteristics of intermediate arrangements (adjustable pegs crawling pegs and target zones and imperative-process "normalization" in the form of a managed or clean floating system. It is established that de iure and de facto classifications generate "fear of floating" and "fear of pegging". The "impossible trinity" under the conditions of capital liberalization and globalization creates a bipolar view or hypothesis of vanishing intermediate exchange rate regimes.

  7. Bijections for the Shi and Ish arrangements

    Leven, Emily; Rhoades, Brendon; Wilson, Andrew Timothy


    The {\\sf Shi hyperplane arrangement} Shi(n) was introduced by Shi to study the Kazhdan-Lusztig cellular structure of the affine symmetric group. The {\\sf Ish hyperplane arrangement} Ish(n) was introduced by Armstrong in the study of diagonal harmonics. Armstrong and Rhoades discovered a deep combinatorial similarity between the Shi and Ish arrangements. We solve a collection of problems posed by Armstrong and Armstrong-Rhoades by giving bijections between regions of Shi(n) and Ish(n) which pr...

  8. Valve Technology Arrangement of Cryopump: A Review

    Sanjiv Y. Rajput


    Full Text Available A cryopump or a "cryogenic pump" is a vacuum pump that pumps the trap gases and vapours by condensing them on a cold surface. Helium gas which is very light can only be pumped by Cryopump. Cryopump cannot be used when working for continuous operation as it pumps the effluent till the saturation state is achieved. Then the absorbed gases are to be collected through other mechanical pump through regeneration process. Hence, valve technology arrangement is incorporated with the cryopump in order to achieve the continuous pumping when two cryopump are used in alternate processes (i.e. absorption and regeneration. Various design of Valve technology arrangement is proposed by different researcher all over the world. This review paper focuses on the different proposed valve technology arrangement and elaborately explains the various components of valve technology and concludes the best possible arrangement that can be used in Cryopump.

  9. Metacognitive scaffolding in an innovative learning arrangement

    Molenaar, I.; Boxtel, C.A.M. van; Sleegers, P.J.C.


    This study examined the effects of metacognitive scaffolds on learning outcomes of collaborating students in an innovative learning arrangement. The triads were supported by computerized scaffolds, which were dynamically integrated into the learning process and took a structuring or problematizing

  10. 24 CFR 401.301 - Partnership arrangements.


    ... (MARK-TO-MARKET) Participating Administrative Entity (PAE) and Portfolio Restructuring Agreement (PRA) § 401.301 Partnership arrangements. If the PAE is in a partnership, the PRA must specify the...

  11. Peak load arrangements : Assessment of Nordel guidelines


    Two Nordic countries, Sweden and Finland, have legislation that empowers the TSO to acquire designated peak load resources to mitigate the risk for shortage situations during the winter. In Denmark, the system operator procures resources to maintain a satisfactory level of security of supply. In Norway the TSO has set up a Regulation Power Option Market (RKOM) to secure a satisfactory level of operational reserves at all times, also in winter with high load demand. Only the arrangements in Finland and Sweden fall under the heading of Peak Load Arrangements defined in Nordel Guidelines. NordREG has been invited by the Electricity Market Group (EMG) to evaluate Nordel's proposal for 'Guidelines for transitional Peak Load Arrangements'. The EMG has also financed a study made by EC Group to support NordREG in the evaluation of the proposal. The study has been taken into account in NordREG's evaluation. In parallel to the EMG task, the Swedish regulator, the Energy Markets Inspectorate, has been given the task by the Swedish government to investigate a long term solution of the peak load issue. The Swedish and Finnish TSOs have together with Nord Pool Spot worked on finding a harmonized solution for activation of the peak load reserves in the market. An agreement accepted by the relevant authorities was reached in early January 2009, and the arrangement has been implemented since 19th January 2009. NordREG views that the proposed Nordel guidelines have served as a starting point for the presently agreed procedure. However, NordREG does not see any need to further develop the Nordel guidelines for peak load arrangements. NordREG agrees with Nordel that the market should be designed to solve peak load problems through proper incentives to market players. NordREG presumes that the relevant authorities in each country will take decisions on the need for any peak load arrangement to ensure security of supply. NordREG proposes that such decisions should be

  12. Domestic arrangements at the Grand Master's Palace

    de Piro, Nicholas; Office of the President of Malta


    A talk in the Rediscovering the Grandmaster's Palace series entitled: Domestic arrangements at the Grandmaster's Palace. This talk is organised by the Office of the President and delivered by Marquis Nicholas DePiro.

  13. Flexible Employment Arrangements and Workplace Performance

    GIOVANIS, Eleftherios


    There is an increasing concern on the quality of jobs and productivity that is witnessed in the flexible employment arrangements. However, the effects of the employment flexible types on workplace performance has not been explored in Britain. In this study the relationship between two employment arrangements and the workplace performance is examined. More specifically, teleworking and compress hours are two main employment types examined using the Workplace Employee R...

  14. Application of arrangement theory to unfolding models

    Kamiya, Hidehiko; Tokushige, Norihide


    Arrangement theory plays an essential role in the study of the unfolding model used in many fields. This paper describes how arrangement theory can be usefully employed in solving the problems of counting (i) the number of admissible rankings in an unfolding model and (ii) the number of ranking patterns generated by unfolding models. The paper is mostly expository but also contains some new results such as simple upper and lower bounds for the number of ranking patterns in the unidimensional case.

  15. Optimal hash arrangement of tentacles in jellyfish

    Okabe, Takuya; Yoshimura, Jin


    At first glance, the trailing tentacles of a jellyfish appear to be randomly arranged. However, close examination of medusae has revealed that the arrangement and developmental order of the tentacles obey a mathematical rule. Here, we show that medusa jellyfish adopt the best strategy to achieve the most uniform distribution of a variable number of tentacles. The observed order of tentacles is a real-world example of an optimal hashing algorithm known as Fibonacci hashing in computer science.

  16. Exchange rate regimes and monetary arrangements

    Ivan Ribnikar


    Full Text Available There is a close relationship between a country’s exchange rate regime and monetary arrangement and if we are to examine monetary arrangements then exchange rate regimes must first be analysed. Within the conventional and most widely used classification of exchange rate regimes into rigid and flexible or into polar regimes (hard peg and float on one side, and intermediate regimes on the other there, is a much greater variety among intermediate regimes. A more precise and, as will be seen, more useful classification of exchange rate regimes is the first topic of the paper. The second topic is how exchange rate regimes influence or determine monetary arrangements and monetary policy or monetary policy regimes: monetary autonomy versus monetary nonautonomy and discretion in monetary policy versus commitment in monetary policy. Both topics are important for countries on their path to the EU and the euro area

  17. The making of local hospital discharge arrangements

    Burau, Viola; Bro, Flemming


    Background Timely discharge is a key component of contemporary hospital governance and raises questions about how to move to more explicit discharge arrangements. Although associated organisational changes closely intersect with professional interests, there are relatively few studies...... and involvement in the process of organisational change: whereas in the ‘add on’ model the professional groups remain at a distance, in the ‘embedded model’ they are closely engaged. Conclusions In terms of understanding the making of hospital discharge arrangements, the study contributes two sets of insights...... in the literature on hospital discharge that explicitly examine the role of professional groups. Recent contributions to the literature on organisational studies of the professions help to specify how professional groups in hospitals contribute to the introduction and routinisation of discharge arrangements...

  18. Arranged matches and mental illness: therapists' dilemmas.

    Greenberg, David; Buchbinder, Jacob Tuvia; Witztum, Eliezer


    Traditional societies place especial value on marriage and having children, and marriages are often arranged. A series of situations and dilemmas associated with arranged matches and their consequences are described in the course of mental health work with ultra-orthodox Jewish people with severe mental illness. Issues of confidentiality may arise with parents and matchmakers; on the other hand, respectful cooperation with religious authorities, counselors in the community, and family members is important. Information on genetic counseling, contraception, medication during pregnancy, and breastfeeding are considered and interact with communal structures and practices. There is a need for close support and evaluation during the process of marriage, childbearing, and parenthood.

  19. Thermal energy recycling fuel cell arrangement

    Hanrahan, Paul R.


    An example fuel cell arrangement includes a fuel cell stack configured to receive a supply fluid and to provide an exhaust fluid that has more thermal energy than the supply fluid. The arrangement also includes an ejector and a heat exchanger. The ejector is configured to direct at least some of the exhaust fluid into the supply fluid. The heat exchanger is configured to increase thermal energy in the supply fluid using at least some of the exhaust fluid that was not directed into the supply fluid.

  20. The Monodromy Conjecture for hyperplane arrangements

    Budur, Nero; Teitler, Zach


    The Monodromy Conjecture asserts that if c is a pole of the local topological zeta function of a hypersurface, then exp(2\\pi c) is an eigenvalue of the monodromy on the cohomology of the Milnor fiber. A stronger version of the conjecture asserts that every pole is a root of the Bernstein-Sato polynomial of the hypersurface. In this note we prove the weak version of the conjecture for hyperplane arrangements. Furthermore, we reduce the strong version to the following conjecture: -n/d is always a root of the Bernstein-Sato polynomial of an indecomposable essential central hyperplane arrangement of d hyperplanes in the affine n-space.

  1. People management implications of virtual workplace arrangements

    K. Ortlepp


    Full Text Available Purpose: The purpose of this paper is to investigate the factors that led to an organisation implementing a particular form of virtual workplace arrangement, namely, home-based work. The benefits and disadvantages associated with this form of work arrangement are explored from both the managers' and home-based employees' perspectives. Design/Methodology/Approach: Given the exploratory nature of the empirical study on which this paper is based, a qualitative research design was adopted so as to ensure that the data collection process was dynamic and probing in nature. Semi-structured in-depth interviews were therefore used as instruments for data collection. Findings: The research findings indicate that virtual work arrangements such as home-based work arrangements have advantages for both employers and employees. For instance, reduction of costs associated with office space and facilities, decrease in absenteeism rates, increased employee job satisfaction and improvements in employees' general quality of life. However, a number of negative experiences related to this form of virtual work arrangement are also evident, for example, feelings of isolation as well as stress related to the inability to have firm boundaries between work and family responsibilities. Implications: Based on the insights gained from the findings in the empirical study, a number of areas that need to be given specific attention when organisations are introducing virtual workplace arrangements of this nature are identified. Recommendations made in this article are important for human resource management specialists as well as core business policy makers considering different forms of organisational design. Originality/Value: Maximising the quality of production and service provided has become the prime objective in most organisations in the 21st century. Technology has made it possible for some jobs to be performed at any place at any time and has facilitated the

  2. Thermal energy recycling fuel cell arrangement

    Hanrahan, Paul R.


    An example fuel cell arrangement includes a fuel cell stack configured to receive a supply fluid and to provide an exhaust fluid that has more thermal energy than the supply fluid. The arrangement also includes an ejector and a heat exchanger. The ejector is configured to direct at least some of the exhaust fluid into the supply fluid. The heat exchanger is configured to increase thermal energy in the supply fluid using at least some of the exhaust fluid that was not directed into the supply fluid.

  3. Cooling arrangement for a gas turbine component

    Lee, Ching-Pang; Heneveld, Benjamin E


    A cooling arrangement (82) for a gas turbine engine component, the cooling arrangement (82) having a plurality of rows (92, 94, 96) of airfoils (98), wherein adjacent airfoils (98) within a row (92, 94, 96) define segments (110, 130, 140) of cooling channels (90), and wherein outlets (114, 134) of the segments (110, 130) in one row (92, 94) align aerodynamically with inlets (132, 142) of segments (130, 140) in an adjacent row (94, 96) to define continuous cooling channels (90) with non continuous walls (116, 120), each cooling channel (90) comprising a serpentine shape.

  4. 75 FR 25150 - NVOCC Negotiated Rate Arrangements


    ... requirement inhibits the beneficial effects of competition for shippers (NYNJFFF&BA at 3); that the tariff... shippers can rely on tariff rates to be accurate, complete and in effect for 30 days; in the event of a... exemption for non-vessel-operating common carriers agreeing to negotiated rate arrangements from...

  5. Arranging a Library to Support Adolescent Development

    Cesari, Lindsay


    When designing a school library space and deciding how to arrange resources, it is important to consider multiple components of adolescent development, including social, emotional, and behavioral aspects. Acknowledging these developmental facets and their importance can provide additional justification for some of the more controversial aspects of…

  6. Partnership Arrangements: Governmental Rhetoric or Governance Scheme?

    G.R. Teisman (Geert); E-H. Klijn (Erik-Hans)


    textabstractIt has become popular to advocate partnership arrangements. Such partnerships may be seen as new forms of governance, which fit in with the imminent network society. However, the idea of partnership is often introduced without much reflection on the need to reorganize policy-making proce

  7. MOX fuel arrangement for nuclear core

    Kantrowitz, Mark L.; Rosenstein, Richard G.


    In order to use up a stockpile of weapons-grade plutonium, the plutonium is converted into a mixed oxide (MOX) fuel form wherein it can be disposed in a plurality of different fuel assembly types. Depending on the equilibrium cycle that is required, a predetermined number of one or more of the fuel assembly types are selected and arranged in the core of the reactor in accordance with a selected loading schedule. Each of the fuel assemblies is designed to produce different combustion characteristics whereby the appropriate selection and disposition in the core enables the resulting equilibrium cycle to closely resemble that which is produced using urania fuel. The arrangement of the MOX rods and burnable absorber rods within each of the fuel assemblies, in combination with a selective control of the amount of plutonium which is contained in each of the MOX rods, is used to tailor the combustion characteristics of the assembly.

  8. Financial arrangement selection for energy management projects

    Woodroof, Eric Aubrey

    Scope and method of study. The purpose of this study was to develop a model (E-FUND) to help facility managers select financial arrangements for energy management projects (EMPs). The model was developed with the help of a panel of expert financiers. The panel also helped develop a list of key objectives critical to the decision process. The E-FUND model was tested by a population of facility managers in four case studies. Findings and conclusions. The results may indicate that having a high economic benefit (from an EMP) is not overwhelmingly important, when compared to other qualitative objectives. The results may also indicate that the true lease and performance contract may be the most applicable financial arrangements for EMPs.

  9. Child Care Arrangements Of Working Mothers

    Singh H


    Full Text Available Children arrangements for infants and preschool children and the reasons for working outside the home were studied in 300 mothers of whom 100 were teachers (Group. I 100 clerks (groups II and 100 tabourers (Group III. The interview method was used. The most common (80% reason for working was financial needs, the next most frequent was utilization of specialized skills. In 58.7% of the cases, substitute childcare was provided by one of the family members, usually the grandmother. Sixty six percent of caretakers were illiterate. Most (93% of the working mothers had also to perform certain household chores. Bottle-feeding was stated at birth by 80% of these mothers: Childcare arrangements for children of working mothers must be considered in the future.

  10. Creating flexible work arrangements through idiosyncratic deals.

    Hornung, Severin; Rousseau, Denise M; Glaser, Jürgen


    A survey of 887 employees in a German government agency assessed the antecedents and consequences of idiosyncratic arrangements individual workers negotiated with their supervisors. Work arrangements promoting the individualization of employment conditions, such as part-time work and telecommuting, were positively related to the negotiation of idiosyncratic deals ("i-deals"). Worker personal initiative also had a positive effect on i-deal negotiation. Two types of i-deals were studied: flexibility in hours of work and developmental opportunities. Flexibility i-deals were negatively related and developmental i-deals positively related to work-family conflict and working unpaid overtime. Developmental i-deals were also positively related to increased performance expectations and affective organizational commitment, while flexibility i-deals were unrelated to either.

  11. Valve Technology Arrangement of Cryopump: A Review

    Sanjiv Y. Rajput


    A cryopump or a "cryogenic pump" is a vacuum pump that pumps the trap gases and vapours by condensing them on a cold surface. Helium gas which is very light can only be pumped by Cryopump. Cryopump cannot be used when working for continuous operation as it pumps the effluent till the saturation state is achieved. Then the absorbed gases are to be collected through other mechanical pump through regeneration process. Hence, valve technology arrangement is incorporated with the c...

  12. Optimum Arrangement of Taxi Drivers’ Working Hours

    TANIZAKI, Takashi


    Part 2: Knowledge Discovery and Sharing; International audience; We propose optimum arrangement of taxi drivers’ working hours. In Japan, income of taxi vehicle is decreasing about 11 thousand yen in the past 15 years. Then some taxi companies are investing to gain more customers. But there are many small taxi companies that are difficult to invest with much money. Therefore we have been researching the other method to gain more customers by little investment for small companies. In this pape...

  13. Simple Euclidean arrangements with one (>=5)-gon

    Leaños, Jesus; Rivera-Martinez, Luis Manuel


    Let L be a simple Euclidean arrangement of n pseudolines. It is shown that if L has exactly one (>=5)=gon P, and k is the number of edges of P that are adjacent to an unbounded cell of the subarrangement of L induced by the pseudolines in P, then L has exactly n-k triangles and k+n(n-5)/2 quadrilaterals. We also prove that if each pseudoline of L is adjacent to P then L is stretchable.

  14. Hyperplane arrangements and Lefschetz's hyperplane section theorem

    Yoshinaga, Masahiko


    The Lefschetz hyperplane section theorem asserts that a complex affine variety is homotopy equivalent to a space obtained from its generic hyperplane section by attaching some cells. The purpose of this paper is to give an explicit description of attaching maps of these cells for the complement of a complex hyperplane arrangement defined over real numbers. The cells and attaching maps are described in combinatorial terms of chambers. We also discuss the cellular chain complex with coefficient...

  15. Generalized Lantern Relations and Planar Line Arrangements

    Hironaka, Eriko


    In this paper we show that to each planar line arrangement defined over the real numbers, for which no two lines are parallel, one can write down a corresponding relation on Dehn twists that can be read off from the combinatorics and relative locations of intersections. This leads to an alternate proof of Wajnryb's generalized lantern relations, and of Endo, Mark and Horn-Morris' daisy relations.

  16. Frequency Arrangement For 700 MHz Band

    Ancans G.


    Full Text Available The 694-790 MHz (700 MHz band was allocated by the 2012 World Radiocommunication Conference (WRC-12 in ITU Region 1 (Europe included, to the mobile service on a co-primary basis with other services to which this band was allocated on the primary basis and identified for the International Mobile Telecommunications (IMT. At the same time, the countries of Region 1 will be able also to continue using these frequencies for their broadcasting services if necessary. This allocation will be effective immediately after 2015 World Radiocommunication Conference (WRC-15. In order to make the best possible use of this frequency band for mobile service, a worldwide harmonized frequency arrangement is to be prepared to allow for large economies of scale and international roaming as well as utilizing the available spectrum in the best possible way, minimizing possible interference between services, facilitating deployment and cross-border coordination. The authors analyze different possible frequency arrangements and conclude on the frequency arrangement most suitable for Europe.

  17. Recurring part arrangements in shape collections

    Zheng, Youyi


    Extracting semantically related parts across models remains challenging, especially without supervision. The common approach is to co-analyze a model collection, while assuming the existence of descriptive geometric features that can directly identify related parts. In the presence of large shape variations, common geometric features, however, are no longer sufficiently descriptive. In this paper, we explore an indirect top-down approach, where instead of part geometry, part arrangements extracted from each model are compared. The key observation is that while a direct comparison of part geometry can be ambiguous, part arrangements, being higher level structures, remain consistent, and hence can be used to discover latent commonalities among semantically related shapes. We show that our indirect analysis leads to the detection of recurring arrangements of parts, which are otherwise difficult to discover in a direct unsupervised setting. We evaluate our algorithm on ground truth datasets and report advantages over geometric similarity-based bottom-up co-segmentation algorithms. © 2014 The Author(s) Computer Graphics Forum © 2014 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.

  18. Minimum Energy Requirements in Complex Distillation Arrangements

    Halvorsen, Ivar J.


    Distillation is the most widely used industrial separation technology and distillation units are responsible for a significant part of the total heat consumption in the world's process industry. In this work we focus on directly (fully thermally) coupled column arrangements for separation of multicomponent mixtures. These systems are also denoted Petlyuk arrangements, where a particular implementation is the dividing wall column. Energy savings in the range of 20-40% have been reported with ternary feed mixtures. In addition to energy savings, such integrated units have also a potential for reduced capital cost, making them extra attractive. However, the industrial use has been limited, and difficulties in design and control have been reported as the main reasons. Minimum energy results have only been available for ternary feed mixtures and sharp product splits. This motivates further research in this area, and this thesis will hopefully give some contributions to better understanding of complex column systems. In the first part we derive the general analytic solution for minimum energy consumption in directly coupled columns for a multicomponent feed and any number of products. To our knowledge, this is a new contribution in the field. The basic assumptions are constant relative volatility, constant pressure and constant molar flows and the derivation is based on Underwood's classical methods. An important conclusion is that the minimum energy consumption in a complex directly integrated multi-product arrangement is the same as for the most difficult split between any pair of the specified products when we consider the performance of a conventional two-product column. We also present the Vmin-diagram, which is a simple graphical tool for visualisation of minimum energy related to feed distribution. The Vmin-diagram provides a simple mean to assess the detailed flow requirements for all parts of a complex directly coupled arrangement. The main purpose in

  19. Improved shock-detection pin arrangement

    Erskine, D.J.


    Shockwave speeds are often measured by comparing arrival times at the tips of electrical shorting pins in a hexagonal array over two elevations (called up and down). In the conventional arrangement, the center pin is solely responsible for measuring the curvature of the wavefront. Without this datum the shock speed cannot be precisely determined. In some experiments this pin fail frequently enough to be a problem. We report a simple rearrangement between up and down designated pins which eliminates the critical reliance on a single.

  20. Ventricular torsional relation to ventricular fiber arrangement

    Ranjbar, Saeed; Meybodi, Mahmood Emami


    Left ventricular torsion from helically oriented myofibers is a key parameter of cardiac performance. Physicians observing heart motion on echocardiograms, during cardiac catheterization, or in the operating room, are impressed by the twisting or rotary motion of the left ventricle during systole. Conceptually, the heart has been treated as a pressure chamber. The rotary or torsional deformation has been poorly understood by basic scientists and has lacked clinical relevance. The aim of this paper attempts to discuss about this question: Is ventricular twisting related to ventricular fiber arrangement? That is dependent to an assumed model of the left ventricular structure.

  1. Waveguide arrangements based on adiabatic elimination

    Suchowski, Haim; Mrejen, Michael; Wu, Chihhui; Zhang, Xiang


    This disclosure provides systems, methods, and apparatus related to nanophotonics. In one aspect, an arrangement of waveguides includes a substrate and three waveguides. Each of the three waveguides may be a linear waveguide. A second waveguide is positioned between a first waveguide and a third waveguide. The dimensions and positions of the first, the second, and the third waveguides are specified to substantially eliminate coupling between the first waveguide and the third waveguide over a distance of about 1 millimeter to 2 millimeters along lengths of the first waveguide, the second waveguide, and the third waveguide.

  2. A regional arrangement proposal for the UNASUR

    Fernando Ferrari-Filho


    Full Text Available The article analyses the current process of economic integration in South America. Thus, concentrating our attention on the UNASUR regional integration process, two questions arise: First, is UNASUR the most viable institution to achieve a consistent economic integration process in South America? Second, what model of economic integration should be adopted in the case of UNASUR, which would ensure macroeconomic stability and avoid financial and exchange rate crises in the South America? To answer these questions, the article proposes, based on the Keynes (1944/1980's revolutionary analysis presented in his International Clearing Union, during the Bretton Woods Conference in 1944, a regional arrangement to UNASUR.

  3. On the connectivity of the realization spaces of line arrangements

    Nazir, Shaheen


    We prove that under certain combinatorial conditions, the realization spaces of line arrangements on the complex projective plane are connected. We also give several examples of arrangements with eight, nine and ten lines which have disconnected realization spaces.

  4. 48 CFR 252.239-7008 - Reuse arrangements.


    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reuse arrangements. 252... Provisions And Clauses 252.239-7008 Reuse arrangements. As prescribed in 239.7411(a), use the following clause: Reuse Arrangements (DEC 1991) (a) When feasible, the Contractor shall reuse canceled...

  5. European top managers' support for work-life arrangements

    Been, W.M.


    In recent decades, work-life arrangements increasingly became an integral part of the organization of work. Arrangements such as telecommuting, flextime, part-time hours, and various types of leave arrangements are available to employees in many organizations. Top managers, such as CEOs, CFOs and me

  6. Tendons Arrangement Effects on Reinforced Concrete Frames

    Ayad B. Bahnam


    Full Text Available  The tendons arrangement effects on the response of reinforced concrete frame experiencing blast loads is investigated in this paper. The structure is modeled using nonlinear finite elements employing a bilinear hysteretic model. So that elements are used so that yielding of the structures could be accurately modeled and captured. The frame is analyzed using a non-linear, elastic-plastic finite element program written in code MATLAB. Six tendon architectures were investigated. A single tendon was placed between different floors and its effects investigated. From the obtained results, the ideal case which causes a reduction in the maximum displacement and the amount of permanent deflection without increase in the maximum structural shear forces greatly is obtained.

  7. Rim seal arrangement having pumping feature

    Lee, Ching-Pang; Myers, Caleb


    A rim seal arrangement for a gas turbine engine includes a first seal face on a rotor component, and a second seal face on a stationary annular rim centered about a rotation axis of the rotor component. The second seal face is spaced from the first seal face along an axial direction to define a seal gap. The seal gap is located between a radially outer hot gas path and a radially inner rotor cavity. The first seal face has a plurality of circumferentially spaced depressions, each having a depth in an axial direction and extending along a radial extent of the first seal face. The depressions influence flow in the seal gap such that during rotation of the rotor component, fluid in the seal gap is pumped in a radially outward direction to prevent ingestion of a gas path fluid from the hot gas path into the rotor cavity.

  8. Factored Facade Acquisition using Symmetric Line Arrangements

    Ceylan, Duygu


    We introduce a novel framework for image-based 3D reconstruction of urban buildings based on symmetry priors. Starting from image-level edges, we generate a sparse and approximate set of consistent 3D lines. These lines are then used to simultaneously detect symmetric line arrangements while refining the estimated 3D model. Operating both on 2D image data and intermediate 3D feature representations, we perform iterative feature consolidation and effective outlier pruning, thus eliminating reconstruction artifacts arising from ambiguous or wrong stereo matches. We exploit non-local coherence of symmetric elements to generate precise model reconstructions, even in the presence of a significant amount of outlier image-edges arising from reflections, shadows, outlier objects, etc. We evaluate our algorithm on several challenging test scenarios, both synthetic and real. Beyond reconstruction, the extracted symmetry patterns are useful towards interactive and intuitive model manipulations.

  9. Arrangement Computation for Planar Algebraic Curves

    Berberich, Eric; Kobel, Alexander; Sagraloff, Michael


    We present a new certified and complete algorithm to compute arrangements of real planar algebraic curves. Our algorithm provides a geometric-topological analysis of the decomposition of the plane induced by a finite number of algebraic curves in terms of a cylindrical algebraic decomposition of the plane. Compared to previous approaches, we improve in two main aspects: Firstly, we significantly reduce the amount of exact operations, that is, our algorithms only uses resultant and gcd as purely symbolic operations. Secondly, we introduce a new hybrid method in the lifting step of our algorithm which combines the usage of a certified numerical complex root solver and information derived from the resultant computation. Additionally, we never consider any coordinate transformation and the output is also given with respect to the initial coordinate system. We implemented our algorithm as a prototypical package of the C++-library CGAL. Our implementation exploits graphics hardware to expedite the resultant and gcd...

  10. Common themes and cell type specific variations of higher order chromatin arrangements in the mouse

    Cremer Thomas


    Full Text Available Abstract Background Similarities as well as differences in higher order chromatin arrangements of human cell types were previously reported. For an evolutionary comparison, we now studied the arrangements of chromosome territories and centromere regions in six mouse cell types (lymphocytes, embryonic stem cells, macrophages, fibroblasts, myoblasts and myotubes with fluorescence in situ hybridization and confocal laser scanning microscopy. Both species evolved pronounced differences in karyotypes after their last common ancestors lived about 87 million years ago and thus seem particularly suited to elucidate common and cell type specific themes of higher order chromatin arrangements in mammals. Results All mouse cell types showed non-random correlations of radial chromosome territory positions with gene density as well as with chromosome size. The distribution of chromosome territories and pericentromeric heterochromatin changed during differentiation, leading to distinct cell type specific distribution patterns. We exclude a strict dependence of these differences on nuclear shape. Positional differences in mouse cell nuclei were less pronounced compared to human cell nuclei in agreement with smaller differences in chromosome size and gene density. Notably, the position of chromosome territories relative to each other was very variable. Conclusion Chromosome territory arrangements according to chromosome size and gene density provide common, evolutionary conserved themes in both, human and mouse cell types. Our findings are incompatible with a previously reported model of parental genome separation.

  11. Strike a balance with flexible working arrangements

    Madison, Alison L.


    Monthly Economic Diversity column for the Tri-City Herald - Topic: Telworking - Excerpt below: As the holiday season kicks into high gear, work-life balance is on many of our minds. How can I meet all of my work commitments this month when no one will be in the office, and still strategically use very little vacation time to stretch the holiday break from four days to fourteen? Am I right? I think most all of us want to stay engaged with our professional lives while maintaining the freedom to prioritize our personal lives. And many employers have come up with ways to help us achieve that balance. Teleworking is not a brand new concept, but is certainly gaining steam as employers and employees alike try to find ways to meet a variety of wants and needs. There are benefits to both sides when it comes to offering flexible working arrangements such as teleworking. For businesses attempting to meet sustainability targets by reducing employee commuting and associated impacts to energy and environment, the benefits of this option can really add up.

  12. Nonstandard work arrangements and worker health and safety.

    Howard, John


    Arrangements between those who perform work and those who provide jobs come in many different forms. Standard work arrangements now exist alongside several nonstandard arrangements: agency work, contract work, and gig work. While standard work arrangements are still the most prevalent types, the rise of nonstandard work arrangements, especially temporary agency, contract, and "gig" arrangements, and the potential effects of these new arrangements on worker health and safety have captured the attention of government, business, labor, and academia. This article describes the major work arrangements in use today, profiles the nonstandard workforce, discusses several legal questions about how established principles of labor and employment law apply to nonstandard work arrangements, summarizes findings published in the past 20 years about the health and safety risks for workers in nonstandard work arrangements, and outlines current research efforts in the area of healthy work design and worker well-being. Am. J. Ind. Med. 60:1-10, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. Optical properties of quasiperiodically arranged semiconductor nanostructures

    Werchner, Marco


    This work consists of two parts which are entitled ''One-Dimensional Resonant Fibonacci Quasicrystals'' and ''Resonant Tunneling of Light in Silicon Nanostructures''. A microscopic theory has been applied to investigate the optical properties of the respective semiconductor nanostructures. The studied one-dimensional resonant Fibonacci quasicrystals consist of GaAs quantum wells (QW) that are separated by either a large spacer L or a small one S. These spacers are arranged according to the Fibonacci sequence LSLLSLSL.. The average spacing satisfies a generalized Bragg condition with respect to the 1s-exciton resonance of the QWs. A theory, that makes use of the transfer-matrix method and that allows for the microscopic description of many-body effects such as excitation-induced dephasing caused by the Coulomb scattering of carriers, has been applied to compute the optical spectra of such structures. A pronounced sharp reflectivity minimum is found in the vicinity of the heavy-hole resonance both in the measured as well as in the calculated linear 54-QW spectra. Specifically, the influence of the carrier density, of the QW arrangement, of a detuning away from the exact Bragg condition, of the average spacing as well as of the ratio of the optical path lengths of the large and small spacers L and S, respectively, and of the QW number on the optical properties of the samples have been studied. Additionally, self-similarity among reflection spectra corresponding to different QW numbers that exceed a Fibonacci number by one is observed, which identifies certain spectral features as true fingerprints of the Fibonacci spacing. In the second part, resonant tunneling of light in stacked structures consisting of alternating parallel layers of silicon and air have been studied theoretically.Light may tunnel through the air barrier due to the existence of evanescent waves inside the air layers if the neighboring silicon layer is close

  14. Human Rights Arrangement on Indonesian Law

    S. Masribut Sardol


    Full Text Available Article 1 paragraph (3 of the Constitution of 1945 (UUD 1945 stated that Indonesia is a Rule of Law. One feature of the Rule of Law is the existence of human rights in the state administration. Indonesia, since independence on August 17, 1945 has asserted the defense of human rights as stated in the opening clause and in the torso of the 1945 Constitution Article 27-34. In the era of reform, on the Government of President Habibie, the President and the Parliament ratified the UN convention against torture and other cruel, inhuman, or degrading human dignity into Law number 5 of 1998. Then the MPR also publishes the statutes of MPR No. XVII/MPR/1998 on Human Rights, which was followed up with the appearance of Law No. 39 of 1999 on human rights. In accordance with the law in Indonesia based on the sort of Law No. 12 of 2011, the actual products that have been issued by the Government (the MPR, DPR and President that follow up the substance of Human Rights in the Constitution with established Assembly and the law is already correct. But when the MPR then does the second amendment to the Constitution on August 18, 2000 by adding a special article chapters and contains about Human Rights (as mentioned in Chapter X-A section 28 A-J, have made the complexity hierarchy of law in Indonesia because it is not in accordance with the substance of article 7 of Law No. 12 of 2011. How To Cite: Sardol, S. (2014. Human Rights Arrangement on Indonesian Law. Rechtsidee, 1(1, 85-100. doi:

  15. Gene

    U.S. Department of Health & Human Services — Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes,...

  16. Multiple childcare arrangements and health outcomes in early childhood.

    Chen, Jen-Hao


    This study examined the associations between multiple childcare arrangements and young children's health problems. This study used three waves of the Early Childhood Longitudinal Study-Birth Cohort, collected from a nationally representative sample of children when they were 9 months old, 2 years old, and 4 years old (N = 7,150). 'Multiple childcare arrangements' was defined and measured by the number of non-parental childcare arrangements that occurred on a regular basis. During each wave of the data collection, the mother reported the number of regular childcare arrangements by three types: relative care, non-relative care, and center-based care. These numbers were summed to calculate the total number of arrangements. The mother also reported the incidence of ear infections, gastrointestinal illnesses, asthma diagnosis, and unintentional injuries of the child. Random effects and fixed effects regression models were used to estimate the association between the number of childcare arrangements and measures of early childhood health problems. Increases in the total number of childcare arrangements were associated with an elevated risk of ear infections, gastrointestinal illnesses, and diagnosed asthma in children. Further analysis indicates that increases in both the number of center-based care and non-relative care (but not relative care) arrangements can lead to a greater chance of health problems in young children. Multiple childcare arrangements are associated with communicable illness and diagnosed asthma in early childhood and appear to be a risk factor for health problems in early childhood.

  17. Arithmetic matroids, the Tutte polynomial and toric arrangements

    D’Adderio, Michele; Moci, Luca


    .... Guided by the geometry of generalized toric arrangements, we provide a combinatorial interpretation of the associated arithmetic Tutte polynomial, which can be seen as a generalization of Crapo's...

  18. Chorein Sensitive Arrangement of Cytoskeletal Architecture

    Sabina Honisch


    Full Text Available Background/Aims: Chorein is a protein expressed in various cell types. Loss of function mutations of the chorein encoding gene VPS13A lead to chorea-acanthocytosis, an autosomal recessive genetic disease characterized by movement disorder and behavioral abnormalities. Recent observations revealed that chorein is a powerful regulator of actin cytoskeleton in erythrocytes, platelets, K562 and endothelial HUVEC cells. Methods: In the present study we have used Western blotting to study actin polymerization dynamics, laser scanning microscopy to evaluate in detail the role of chorein in microfilaments, microtubules and intermediate filaments cytoskeleton architecture and RT-PCR to assess gene transcription of the cytoskeletal proteins. Results: We report here powerful depolymerization of actin microfilaments both, in erythrocytes and fibroblasts isolated from chorea-acanthocytosis patients. Along those lines, morphological analysis of fibroblasts from chorea-acanthocytosis patients showed disarranged microtubular network, when compared to fibroblasts from healthy donors. Similarly, the intermediate filament networks of desmin and cytokeratins showed significantly disordered organization with clearly diminished staining in patient's fibroblasts. In line with this, RT-PCR analysis revealed significant downregulation of desmin and cytokeratin gene transcripts. Conclusion: Our results provide for the first time evidence that defective chorein is accompanied by significant structural disorganization of all cytoskeletal structures in human fibroblasts from chorea-acanthocytosis patients.

  19. Oil Recovery of Soil Contained Petroleum Oil by Using Bio surfactant of Mixed Cultures Bacteria (Brevundumonas diminuta, Pseudomonas fluorescens, Pseudomonas aeroginosa, Pseudomonas citronelis at vary pH Conditions (5-9

    Bambang Yudono


    Full Text Available Abstract The bacteria (Brevundumonas diminuta, Pseudomonas fluorescens, Pseudomonas aeroginosa, Pseudomonas citronelbis which are indigenous bacteria from Babat Toman village South Sumatra. It were isolated and identified by using Bergey's method. In the normal condition (pH 7, these bacteria could produce bio surfactant and effectively as mixed culture. The growth of mixed culture of indigenous bacteria was tested at different pH conditions (5-9. The results show that  the optimum pH was obtained at pH 7, the population of bacteria was  2.14.107 cfu/mL. The shortest regeneration time of these bacteria were (12, 12, 9, 9 hours respectively. The initial total petroleum hydrocarbon concentration of sample was 18,4 %, it was extracted by using the bio surfactant of mixed culture with 10 % concentration at different pH conditions (5-9, the contact time as long as 168 hours. The optimal oil recovery was obtained at pH 7 as much as 20.97 %. It can be concluded that the bio surfactant effectively used in the normal condition (pH 7 and ineffectively in alkaline condition (pH 9.The GC analyses were conducted to initial crude oil and the residue. The results show that the crude oil consists of 33 components, and the residue consists of 14 components. It shows that the bio surfactant of mixed culture bacteria dissolved the hydrocarbon components with temperature fractions 150, 155, 178, 184, 190, and 197 o C.  

  20. CHD6 regulates the topological arrangement of the CFTR locus.

    Sancho, Ana; Li, SiDe; Paul, Thankam; Zhang, Fan; Aguilo, Francesca; Vashisht, Ajay; Balasubramaniyan, Natarajan; Leleiko, Neal S; Suchy, Frederick J; Wohlschlegel, James A; Zhang, Weijia; Walsh, Martin J


    The control of transcription is regulated through the well-coordinated spatial and temporal interactions between distal genomic regulatory elements required for specialized cell-type and developmental gene expression programs. With recent findings CFTR has served as a model to understand the principles that govern genome-wide and topological organization of distal intra-chromosomal contacts as it relates to transcriptional control. This is due to the extensive characterization of the DNase hypersensitivity sites, modification of chromatin, transcription factor binding sites and the arrangement of these sites in CFTR consistent with the restrictive expression in epithelial cell types. Here, we identified CHD6 from a screen among several chromatin-remodeling proteins as a putative epigenetic modulator of CFTR expression. Moreover, our findings of CTCF interactions with CHD6 are consistent with the role described previously for CTCF in CFTR regulation. Our results now reveal that the CHD6 protein lies within the infrastructure of multiple transcriptional complexes, such as the FACT, PBAF, PAF1C, Mediator, SMC/Cohesion and MLL complexes. This model underlies the fundamental role CHD6 facilitates by tethering cis-acting regulatory elements of CFTR in proximity to these multi-subunit transcriptional protein complexes. Finally, we indicate that CHD6 structurally coordinates a three-dimensional stricture between intragenic elements of CFTR bound by several cell-type specific transcription factors, such as CDX2, SOX18, HNF4α and HNF1α. Therefore, our results reveal new insights into the epigenetic regulation of CFTR expression, whereas the manipulation of CFTR gene topology could be considered for treating specific indications of cystic fibrosis and/or pancreatitis.

  1. Genes V.

    Lewin, B.


    This fifth edition book encompasses a wide range of topics covering 1,272 pages. The book is arranged into nine parts with a total of 36 chapters. These nine parts include Introduction; DNA as a Store of Information; Translation; Constructing Cells; Control of Prokaryotypic Gene Expression; Perpetuation of DNA; Organization of the Eukaryotypic Genome; Eukaryotypic Transcription and RNA Processing; The Dynamic Genome; and Genes in Development.

  2. Evolution of gastropod mitochondrial genome arrangements

    Zardoya Rafael


    Full Text Available Abstract Background Gastropod mitochondrial genomes exhibit an unusually great variety of gene orders compared to other metazoan mitochondrial genome such as e.g those of vertebrates. Hence, gastropod mitochondrial genomes constitute a good model system to study patterns, rates, and mechanisms of mitochondrial genome rearrangement. However, this kind of evolutionary comparative analysis requires a robust phylogenetic framework of the group under study, which has been elusive so far for gastropods in spite of the efforts carried out during the last two decades. Here, we report the complete nucleotide sequence of five mitochondrial genomes of gastropods (Pyramidella dolabrata, Ascobulla fragilis, Siphonaria pectinata, Onchidella celtica, and Myosotella myosotis, and we analyze them together with another ten complete mitochondrial genomes of gastropods currently available in molecular databases in order to reconstruct the phylogenetic relationships among the main lineages of gastropods. Results Comparative analyses with other mollusk mitochondrial genomes allowed us to describe molecular features and general trends in the evolution of mitochondrial genome organization in gastropods. Phylogenetic reconstruction with commonly used methods of phylogenetic inference (ME, MP, ML, BI arrived at a single topology, which was used to reconstruct the evolution of mitochondrial gene rearrangements in the group. Conclusion Four main lineages were identified within gastropods: Caenogastropoda, Vetigastropoda, Patellogastropoda, and Heterobranchia. Caenogastropoda and Vetigastropoda are sister taxa, as well as, Patellogastropoda and Heterobranchia. This result rejects the validity of the derived clade Apogastropoda (Caenogastropoda + Heterobranchia. The position of Patellogastropoda remains unclear likely due to long-branch attraction biases. Within Heterobranchia, the most heterogeneous group of gastropods, neither Euthyneura (because of the inclusion of P

  3. Modular arrangement of regulatory RNA elements

    Roßmanith, Johanna; Narberhaus, Franz


    ABSTRACT Due to their simple architecture and control mechanism, regulatory RNA modules are attractive building blocks in synthetic biology. This is especially true for riboswitches, which are natural ligand-binding regulators of gene expression. The discovery of various tandem riboswitches inspired the design of combined RNA modules with activities not yet found in nature. Riboswitches were placed in tandem or in combination with a ribozyme or temperature-responsive RNA thermometer resulting in new functionalities. Here, we compare natural examples of tandem riboswitches with recently designed artificial RNA regulators suggesting substantial modularity of regulatory RNA elements. Challenges associated with modular RNA design are discussed. PMID:28010165

  4. 29 CFR 779.230 - Franchise and other arrangements.


    ... 29 Labor 3 2010-07-01 2010-07-01 false Franchise and other arrangements. 779.230 Section 779.230... Coverage Leased Departments, Franchise and Other Business Arrangements § 779.230 Franchise and other.... The quotation in § 779.229 from the Senate Report shows that Congress recognized that some...

  5. Living Arrangements and Family Formation Attitudes in Early Adulthood.

    Axinn, William G.; Barber, Jennifer S.


    Examines the impact of nonfamily living arrangements and cohabitation on changes in family formation attitudes at the individual level. Results indicate that both the experience and duration of cohabiting arrangements have significant effects on family formation attitudes but fail to show significant consequences of premarital, nonfamily living…

  6. Exploring living arrangements of divorced families in the Netherlands

    Bakker, W.; Mulder, C.H.


    We aim to gain more insight into the characteristics of divorced families with different types of post-divorce living arrangements, and in particular with co-parenting arrangements in which the child alternates between the parents’ residences. Empirical evidence comes from a mixed- method research,

  7. Territoriality: Seat Preferences in Different Types of Classroom Arrangements

    Kaya, Naz; Burgess, Brigitte


    Students' degree of territoriality based on gender and seat preferences in different types of classroom arrangements was studied. The types of classroom arrangements included rows of tablet-arm chairs, U-shaped, clusters, and rows of tables with individual chairs. The study was carried out through a survey at a large public institution in the…

  8. Do Knowledge Arrangements Affect Student Reading Comprehension of Genetics?

    Wu, Jen-Yi; Tung, Yu-Neng; Hwang, Bi-Chi; Lin, Chen-Yung; Che-Di, Lee; Chang, Yung-Ta


    Various sequences for teaching genetics have been proposed. Three seventh-grade biology textbooks in Taiwan share similar key knowledge assemblages but have different knowledge arrangements. To investigate the influence of knowledge arrangements on student understanding of genetics, we compared students' reading comprehension of the three texts…

  9. Arrangement for carrying out and studying chemical reactions

    Langeveld, A.D.; Makkee, M.; Moulijn, J.A.


    Abstract of NL 9102029 (A) Described is an arrangement for carrying out TAP experiments. Such an arrangement comprises a reaction chamber in which a very short-lived beam of molecules is directed at a target to produce a short-lived beam of intermediate-product molecules, and a vacuum chamber wher

  10. Minimality of hyperplane arrangements and basis of local system cohomology

    Yoshinaga, Masahiko


    The purpose of this paper is applying minimality of hyperplane arrangements to local system cohomology groups. It is well known that twisted cohomology groups with coefficients in a generic rank one local system vanish except in the top degree, and bounded chambers form a basis of the remaining cohomology group. We determine precisely when this phenomenon happens for two dimensional arrangements.

  11. 33 CFR 157.222 - Pump and piping arrangements.


    ... OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels Design and Equipment § 157.222 Pump and piping arrangements. (a) Dedicated clean ballast tanks must be connected to the least practicable: (1... each dedicated clean ballast tank must be arranged so that oily water does not enter any...

  12. 22 CFR 92.63 - Arrangement of papers.


    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Arrangement of papers. 92.63 Section 92.63... and Letters Rogatory § 92.63 Arrangement of papers. Unless special instructions to the contrary are received, the various papers comprising the completed record of the depositions should usually be...

  13. On capital allocation for stochastic arrangement increasing actuarial risks

    Pan Xiaoqing


    Full Text Available This paper studies the increasing convex ordering of the optimal discounted capital allocations for stochastic arrangement increasing risks with stochastic arrangement decreasing occurrence times. The application to optimal allocation of policy limits is presented as an illustration as well.

  14. Do Knowledge Arrangements Affect Student Reading Comprehension of Genetics?

    Wu, Jen-Yi; Tung, Yu-Neng; Hwang, Bi-Chi; Lin, Chen-Yung; Che-Di, Lee; Chang, Yung-Ta


    Various sequences for teaching genetics have been proposed. Three seventh-grade biology textbooks in Taiwan share similar key knowledge assemblages but have different knowledge arrangements. To investigate the influence of knowledge arrangements on student understanding of genetics, we compared students' reading comprehension of the three…

  15. Do Knowledge Arrangements Affect Student Reading Comprehension of Genetics?

    Wu, Jen-Yi; Tung, Yu-Neng; Hwang, Bi-Chi; Lin, Chen-Yung; Che-Di, Lee; Chang, Yung-Ta


    Various sequences for teaching genetics have been proposed. Three seventh-grade biology textbooks in Taiwan share similar key knowledge assemblages but have different knowledge arrangements. To investigate the influence of knowledge arrangements on student understanding of genetics, we compared students' reading comprehension of the three texts…

  16. A Unit Cell Laboratory Experiment: Marbles, Magnets, and Stacking Arrangements

    Collins, David C.


    An undergraduate first-semester general chemistry laboratory experiment introducing face-centered, body-centered, and simple cubic unit cells is presented. Emphasis is placed on the stacking arrangement of solid spheres used to produce a particular unit cell. Marbles and spherical magnets are employed to prepare each stacking arrangement. Packing…

  17. 28 CFR 550.44 - Procedures for arranging drug counseling.


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Procedures for arranging drug counseling... MANAGEMENT DRUG PROGRAMS Drug Services (Urine Surveillance and Counseling for Sentenced Inmates in Contract CTCs) § 550.44 Procedures for arranging drug counseling. The contract center staff shall hold a...

  18. Structure of a double-domain phosphagen kinase reveals an asymmetric arrangement of the tandem domains.

    Wang, Zhiming; Qiao, Zhu; Ye, Sheng; Zhang, Rongguang


    Tandem duplications and fusions of single genes have led to magnificent expansions in the divergence of protein structures and functions over evolutionary timescales. One of the possible results is polydomain enzymes with interdomain cooperativities, few examples of which have been structurally characterized at the full-length level to explore their innate synergistic mechanisms. This work reports the crystal structures of a double-domain phosphagen kinase in both apo and ligand-bound states, revealing a novel asymmetric L-shaped arrangement of the two domains. Unexpectedly, the interdomain connections are not based on a flexible hinge linker but on a rigid secondary-structure element: a long α-helix that tethers the tandem domains in relatively fixed positions. Besides the connective helix, the two domains also contact each other directly and form an interdomain interface in which hydrogen bonds and hydrophobic interactions further stabilize the L-shaped domain arrangement. Molecular-dynamics simulations show that the interface is generally stable, suggesting that the asymmetric domain arrangement crystallographically observed in the present study is not a conformational state simply restrained by crystal-packing forces. It is possible that the asymmetrically arranged tandem domains could provide a structural basis for further studies of the interdomain synergy.


    DRIŞCU Mariana


    Full Text Available By classic methodology, designing footwear is a very complex and laborious activity. That is because classic methodology requires many graphic executions using manual means, which consume a lot of the producer’s time. Moreover, the results of this classical methodology may contain many inaccuracies with the most unpleasant consequences for the footwear producer. Thus, the costumer that buys a footwear product by taking into consideration the characteristics written on the product (size, width can notice after a period that the product has flaws because of the inadequate design. In order to avoid this kind of situations, the strictest scientific criteria must be followed when one designs a footwear product. The decisive step in this way has been made some time ago, when, as a result of powerful technical development and massive implementation of electronical calculus systems and informatics, This paper presents a product software for determining all possible arrangements of a footwear product’s reference points, in order to automatically acquire the maximum arrangement factor. The user multiplies the pattern in order to find the economic arrangement for the reference points. In this purpose, the user must probe few arrangement variants, in the translation and rotate-translation system. The same process is used in establishing the arrangement factor for the two points of reference of the designed footwear product. After probing several variants of arrangement in the translation and rotation and translation systems, the maximum arrangement factors are chosen. This allows the user to estimate the material wastes.

  20. William Barlow and the Determination of Atomic Arrangement in Crystals.

    Mauskopf, Seymour H


    William Barlow (1845-1934) was an important if unconventional scientist, known for having developed the 'closest-packing' atomic models of crystal structure. He resumed an early nineteenth-century tradition of utilizing crystallographical and chemical data to determine atomic arrangements in crystals. This essay recounts Barlow's career and scientific activity in three parts: (a) His place in the tradition of determining atomic arrangement in context of this earlier tradition and of contemporaneous developments of crystallography and chemistry, (b) his unconventional career, and (c) the 'success' of his program to determine atomic arrangements in crystals and its influence on the work of William Lawrence Bragg.

  1. Complements and higher resonance varieties of hyperplane arrangements

    Budur, Nero


    Hyperplane arrangements form the geometric counterpart of combinatorial objects such as matroids. The shape of the sequence of Betti numbers of the complement of a hyperplane arrangement is of particular interest in combinatorics, where they are known, up to a sign, as Whitney numbers of the first kind, and appear as the coefficients of chromatic, or characteristic, polynomials. We show that certain combinations, some nonlinear, of these Betti numbers satisfy Schur positivity. At the same time, we study the higher degree resonance varieties of the arrangement. We draw some consequences, using homological algebra results and vector bundles techniques, of the fact that all resonance varieties are determinantal.

  2. Designing a Miniature Wheel Arrangement for Mobile Robot Platforms

    Kayani, Saheeb Ahmed


    In this research report details of design of a miniature wheel arrangement are presented. This miniature wheel arrangement is essentially a direction control mechanism intended for use on a mobile robot platform or base. The design is a specific one employing a stepper motor as actuator and as described can only be used on a certain type of wheeled robots. However as a basic steering control element, more than one of these miniature wheel arrangements can be grouped together to implement more elaborate and intelligent direction control schemes on varying configurations of wheeled mobile robot platforms.

  3. The primitive derivation and freeness of multi-Coxeter arrangements

    Yoshinaga, Masahiko


    We will prove the freeness of multi-Coxeter arrangements by constructing a basis of the module of vector fields which contact to each reflecting hyperplanes with some multiplicities using K. Saito's theory of primitive derivation.

  4. Birthday Cake Activity Structured Arrangement for Helping Children Determining Quantities

    Neni Mariana


    Full Text Available Few researches have been concerned about relation between children’s spatial thinking and number sense. Narrowing for this small research, we focused on one component of spatial thinking, that is structuring objects, and one component of number senses, that is cardinality by determining quantities. This study focused on a design research that was conducted in Indonesia in which we investigated pre-school children’s (between 2 and 3.5 years old ability in making structured arrangement and their ability to determine the quantities by looking at the arrangements. The result shows us that some of the children were able to make such arrangement. However, the children found difficulties either to determine quantities from those arrangements or to compare some structures to easily recognize number of objects.

  5. Children's postdivorce residence arrangements and parental experienced time pressure

    van der Heijden, Franciëlla; Poortman, Anne Rigt; van der Lippe, Tanja


    Although the rise in postdivorce joint physical custody has fueled scholarly interest in its impact on children, consequences for parents remain understudied. Because children's residence arrangements determine time and coordination demands associated with child care, this study investigated the rel

  6. Children's postdivorce residence arrangements and parental experienced time pressure

    van der Heijden, Franciëlla; Poortman, Anne Rigt; van der Lippe, Tanja


    Although the rise in postdivorce joint physical custody has fueled scholarly interest in its impact on children, consequences for parents remain understudied. Because children's residence arrangements determine time and coordination demands associated with child care, this study investigated the

  7. Children's postdivorce residence arrangements and parental experienced time pressure

    van der Heijden, Franciëlla; Poortman, Anne Rigt; van der Lippe, Tanja


    Although the rise in postdivorce joint physical custody has fueled scholarly interest in its impact on children, consequences for parents remain understudied. Because children's residence arrangements determine time and coordination demands associated with child care, this study investigated the rel

  8. Arranging transient process used in iterative learning control system


    Considering the same initial state error in each repetitive operation in the iterative learning system, a method of arranging the transient process is given. During the current iteration, the system will track the transient function firstly, and then the expected trajectory. After several iterations, the learning system output will trend to the arranged curve, which has avoided the effect of the initial error on the controller. Also the transient time can be changed as you need, which makes the designing si...

  9. Contractual Arrangement and Marketing Practices in the Indirect Export Channel

    Daniel C Bello; Nicholas C Williamson


    The association between contractual arrangement and the marketing practices of export intermediaries and domestic supplies is examined. Based on data collected from a national sample of export management companies, the effect of structuring the export arrangement as a contractual, administrative, or conventional channel is analyzed. Prior research suggests that contractual form establishes the framework within which all the economic and sociopolitical interactions between the supplier and exp...

  10. Modelling and arrangement of composite panels in modernized freight cars

    Płaczek Marek


    Full Text Available A process of modelling in a CAD system and designing of arrangement of composite panels used for freight cars’ body shell protection against corrosion and for easier unloading of transported cargo in winter conditions is presented in this work. Arrangement of used composite panels was designing in order to fulfil assumed criteria and thus to improve the process of freight cars modernization during periodic repairs.

  11. Islamic versus conventional banking: A comparative analysis of financial arrangements

    Marinković, Srđan


    The paper explores the concept of Islamic banking by making comparison between the basic features of some key conventional and Islamic financial arrangements. Paradigm version of Islamic banking forbids arrangements based on a predetermined rate of return on financial investments, instead it proposes equity based modes of finance which promote partnership between financier and an entrepreneur. Nevertheless, the theoretically suggested concepts in current practice are faced with serious diffic...

  12. Labour Arrangements in Cassava Production in Oyo State, Nigeria

    Abila, N.


    Full Text Available The study examined the effects of labour arrangements on the profitability of cassava enterprises in Oyo North Area of Oyo State, Nigeria. A multi-stage sampling technique was adopted for data collection, while data were analysed using descriptive statistics and budgetary analysis. The results show that the prevalent labour arrangements for cassava enterprises are: a combination of Family, Hired and Contract labour (38.9%; Family-Hired labour (27.8%; Family-Contract labour (31.1%. The gross margin per hectares across labour arrangements are N279481.99 (all-labour, N286044.24 (family-hired, N216940.10 (familycontract, and N235000.00 (family only. The returns on a naira invested on variable costs across different labour arrangements for cassava enterprises are N2.04 (all-labour, N3.66 (family-hired, N2.37 (familycontract, and N2.61 (family only. This implies that a unit (N1 variable cost in the various labour arrangements of all-labour, family/hired, family/contract and family only in cassava production will yield a marginal return of N3.04, N3.66, N2.37 and N2.61 respectively. Family-hired labour arrangement yields higher marginal return per unit of manday and one naira spent than all other arrangements. The study recommends among others the application of laboursaving technologies and an optimum combination of various labour arrangements to reduce the cost of labour used in cassava production.

  13. AC losses in circular arrangements of parallel superconducting tapes

    Kühle (fratrådt), Anders Van Der Aa; Træholt, Chresten; Däumling, Manfred


    The DC and AC properties of superconducting tapes connected in parellel and arranged in a single closed layer on two tubes (correspondig to power cable models with infinite pitch) with different diameters are compared. We find that the DC properties, i.e. the critical currents of the two arrangem......The DC and AC properties of superconducting tapes connected in parellel and arranged in a single closed layer on two tubes (correspondig to power cable models with infinite pitch) with different diameters are compared. We find that the DC properties, i.e. the critical currents of the two...... arrangements, scale with the number of tapes and hence appear to be independent of the diameter.However, the AC loss per tape (for a given current per tape) appears to decrease with increasing diameter of the circular arrangement. Compared to a model for the AC loss in a continuous superconducting layer...... (Monoblock model) the measured values are about half an order of magnitude higher than expected for the small diameter arrangement. When compared to the AC loss calculated for N individual superconducting tapes using a well known model ( Norris elliptical) the difference is slightly smaller....

  14. Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells.

    Orlova, Darya Yu; Stixová, Lenka; Kozubek, Stanislav; Gierman, Hinco J; Šustáčková, Gabriela; Chernyshev, Andrei V; Medvedev, Ruslan N; Legartová, Soňa; Versteeg, Rogier; Matula, Pavel; Stoklasa, Roman; Bártová, Eva


    Although it is well known that chromosomes are non-randomly organized during interphase, it is not completely clear whether higher-order chromatin structure is transmitted from mother to daughter cells. Therefore, we addressed the question of how chromatin is rearranged during interphase and whether heterochromatin pattern is transmitted after mitosis. We additionally tested the similarity of chromatin arrangement in sister interphase nuclei. We noticed a very active cell rotation during interphase, especially when histone hyperacetylation was induced or transcription was inhibited. This natural phenomenon can influence the analysis of nuclear arrangement. Using photoconversion of Dendra2-tagged core histone H4 we showed that the distribution of chromatin in daughter interphase nuclei differed from that in mother cells. Similarly, the nuclear distribution of heterochromatin protein 1β (HP1β) was not completely identical in mother and daughter cells. However, identity between mother and daughter cells was in many cases evidenced by nucleolar composition. Moreover, morphology of nucleoli, HP1β protein, Cajal bodies, chromosome territories, and gene transcripts were identical in sister cell nuclei. We conclude that the arrangement of interphase chromatin is not transmitted through mitosis, but the nuclear pattern is identical in naturally synchronized sister cells. It is also necessary to take into account the possibility that cell rotation and the degree of chromatin condensation during functionally specific cell cycle phases might influence our view of nuclear architecture.

  15. Modelling the development and arrangement of the primary vascular structure in plants.

    Cartenì, Fabrizio; Giannino, Francesco; Schweingruber, Fritz Hans; Mazzoleni, Stefano


    The process of vascular development in plants results in the formation of a specific array of bundles that run throughout the plant in a characteristic spatial arrangement. Although much is known about the genes involved in the specification of procambium, phloem and xylem, the dynamic processes and interactions that define the development of the radial arrangement of such tissues remain elusive. This study presents a spatially explicit reaction-diffusion model defining a set of logical and functional rules to simulate the differentiation of procambium, phloem and xylem and their spatial patterns, starting from a homogeneous group of undifferentiated cells. Simulation results showed that the model is capable of reproducing most vascular patterns observed in plants, from primitive and simple structures made up of a single strand of vascular bundles (protostele), to more complex and evolved structures, with separated vascular bundles arranged in an ordered pattern within the plant section (e.g. eustele). The results presented demonstrate, as a proof of concept, that a common genetic-molecular machinery can be the basis of different spatial patterns of plant vascular development. Moreover, the model has the potential to become a useful tool to test different hypotheses of genetic and molecular interactions involved in the specification of vascular tissues.

  16. Mammalian SEPT9 isoforms direct microtubule-dependent arrangements of septin core heteromers.

    Sellin, Mikael E; Stenmark, Sonja; Gullberg, Martin


    Septin-family proteins assemble into rod-shaped heteromeric complexes that form higher-order arrangements at the cell cortex, where they serve apparently conserved functions as diffusion barriers and molecular scaffolds. There are 13 confirmed septin paralogues in mammals, which may be ubiquitous or tissue specific. Septin hetero-oligomerization appears homology subgroup directed, which in turn determines the subunit arrangement of six- to eight-subunit core heteromers. Here we address functional properties of human SEPT9, which, due to variable mRNA splicing, exists as multiple isoforms that differ between tissues. Myeloid K562 cells express three SEPT9 isoforms, all of which have an equal propensity to hetero-oligomerize with SEPT7-containing hexamers to generate octameric heteromers. However, due to limiting amounts of SEPT9, K562 cells contain both hexameric and octameric heteromers. To generate cell lines with controllable hexamer-to-octamer ratios and that express single SEPT9 isoforms, we developed a gene product replacement strategy. By this means we identified SEPT9 isoform-specific properties that either facilitate septin heteromer polymerization along microtubules or modulate the size range of submembranous septin disks-a prevalent septin structure in nonadhered cells. Our findings show that the SEPT9 expression level directs the hexamer-to-octamer ratio, and that the isoform composition and expression level together determine higher-order arrangements of septins.

  17. Inverse design of LED arrangement for visible light communication systems

    Zheng, Huanhuan; Chen, Jian; Yu, Changyuan; Gurusamy, Mohan


    In this paper, an optimal LED arrangement for indoor visible light communications (VLC) is proposed and numerically investigated. By using the concept of inverse design, the LED distribution can be formulated as a convex optimization problem and resolved accordingly. We show that sufficient brightness and uniform signal to noise ratio (SNR) can be achieved within the indoor coverage by using the proposed optimal LED arrangement, thus enabling the terminal mobility for indoor VLC. In addition, the analysis of delay spread distribution over the receiving plane shows that the design exhibits enhanced tolerance of inter-symbol interference (ISI). With the consideration of cabling cost for practical implementation, the suboptimal LED arrangement design is also investigated. Numerical results indicate that the suboptimal design can reduce the power consumption of the system with acceptable performance degradation.

  18. Do organizational and political-legal arrangements explain financial wrongdoing?

    Prechel, Harland; Zheng, Lu


    The 2008 financial crisis was a systemic problem with deep-rooted structural causes that created opportunities to engage in financial malfeasance, a form of corporate wrongdoing. However, few quantitative studies exist on the effects of organizational and political-legal arrangements on financial malfeasance. In this paper, we examine the effects of organizational and political-legal arrangements that emerged in the 1990s in the FIRE sector (i.e., financial, insurance, and real estate) on financial malfeasance. Our historical contextualization demonstrates how changes in the political-legal arrangements facilitate the emergence of new corporate structures and opportunities for financial malfeasance. Our longitudinal quantitative analysis demonstrates that US FIRE sector corporations with a more complex organizational structure, larger size, lower dividend payment, and higher executive compensation are more prone to commit financial malfeasance. © London School of Economics and Political Science 2016.

  19. Orientations of linear stone arrangements in New South Wales

    Hamacher, Duane W; Norris, Ray P


    We test the hypothesis that Aboriginal linear stone arrangements in New South Wales (NSW) are oriented to cardinal directions. We accomplish this by measuring the azimuths of stone arrangements described in site cards from the NSW Aboriginal Heritage Information Management System. We then survey a subset of these sites to test the accuracy of information recorded on the site cards. We find a preference recorded in the site cards for cardinal orientations among azimuths. The field surveys show that the site cards are reasonably accurate, but the surveyors probably did not correct for magnetic declinations. Using Monte Carlo statistics, we show that these preferred orientations did not occur by chance and that Aboriginal people deliberately aligned these arrangements to the approximate cardinal directions. We briefly explore possible reasons for these preferred orientations and highlight the need for future work.

  20. [Analysis of cell arrangements in Biota orientalis using Fourier transformation].

    Duo, Hua-Qiong; Wang, Xi-Ming


    Fourier transform image-processing technology is applied for determining the cross section cell arrangement of early-wood in Biota orientalis. In this method, the disc-convoluted dot map from each cell radius with 10 pixels is transformed by Fourier transform, generating the angle distribution function in the power spectral pattern. The maximum value is the arrangement of the cell. The results of Fourier transform image-processing technology indicated that the arrangements of the cell of Biota orientalis are 15 degrees in oblique direction, respectively. This method provides a new basis for the digitized identification of the wood, and also the new theoretical research direction for the digitized identification and examination of the wood species.

  1. 29 CFR 779.228 - Types of arrangements contemplated by exception.


    ... Coverage Leased Departments, Franchise and Other Business Arrangements § 779.228 Types of arrangements... section 3(s) would not otherwise apply: (a) Any arrangement, whether by agreement, franchise or...

  2. Developing physician pay arrangements: the cash and care equation.

    Levitch, J H


    Developing physician compensation packages that help a healthcare organization meet its business objectives while satisfying physician pay expectations requires new ways of linking pay to physician performance. Such compensation arrangements specifically should include pay tied to defined performance standards, compensation linked to group performance, performance incentives based on realistic, achievable goals, work performance measured by common criteria, and similar pay ensured for similar work. Final pay arrangements also should include items that are sometimes overlooked, such as fully delineated job responsibilities, performance measures aligned correctly with performance areas, and the value of benefits considered in the cash compensation levels.

  3. Inorganic arrangement crystal beryllium, lithium, selenium and silicon

    Gobato, Ricardo; Fedrigo, Desire Francine Gobato


    The use of inorganic crystals technology has been widely date. Since quartz crystals for watches in the nineteenth century, and common way radio in the early twentieth century, to computer chips with new semiconductor materials. Chemical elements such as beryllium, lithium, selenium and silicon, are widely used in technology. The development of new crystals arising from that arrangement can bring technological advances in several areas of knowledge. The likely difficulty of finding such crystals in nature or synthesized, suggest an advanced study of the subject. A study using computer programs with ab initio method was applied. As a result of the likely molecular structure of the arrangement of a crystal was obtained.

  4. Ladder Arrangement Method for Stealth Design of Vivaldi Antenna Array

    XiaoXiang He


    Full Text Available A novel stealth design method for X-band Vivaldi antenna arrays is proposed in this paper by ladder arrangement along radiation direction. Two-element array, eight-element array, and 3 × 7-element array are investigated in this paper. S parameters, RCSs, and radiation patterns are studied, respectively. According to the ladder arrangement of Vivaldi antennas presented, 16.3 dBsm maximal RCS reduction is achieved with satisfied radiation performance. As simulated and measured, results demonstrate that the effectiveness of the presented low RCS design method is validated.

  5. Diffeomorphic types of complements of nice point arrangements in CP~l

    YAU Stephen S.-T.; YE Fei


    We use a new method to study arrangement in CP~l,define a class of nice point arrangements and show that if two nice point arrangements have the same combinatorics,then their complements are diffeomorphic to each other. In particular,the moduli space of nice point arrangements with same combinatorics in CP~l is connected. It generalizes the result on point arrangements in CP~3 to point arrangements in CP~l for any l.

  6. Diffeomorphic types of complements of nice point arrangements in CP~l

    YAU; Stephen; S.-T.


    We use a new method to study arrangement in CPl,define a class of nice point arrangements and show that if two nice point arrangements have the same combinatorics,then their complements are diffeomorphic to each other.In particular,the moduli space of nice point arrangements with same combinatorics in CPl is connected.It generalizes the result on point arrangements in CP3 to point arrangements in CPl for any l.

  7. Breeding of Brevundimonas diminuta for L-proline and optimization of its fermentation conditions%缺陷短波单胞菌高产L-脯氨酸菌株的选育及其发酵条件优化

    赵世杰; 窦文芳; 李会; 张旦旦; 史劲松; 许正宏


    Brevundimonas diminuta JNPP-1 was used as the original strain for stepwise mutation by ultraviolet (UV) and N-methyl-N-nitro-N-nitrosoguanidine (NTG) treatments. A stable and L-proline overproducing mutant JNPP-NSS (SGr、Sucg、NaClr) was obtained. Through the optimization of batch fermentation condition, the maximum concentration of L-proline reached 47. 3 g/L, which was 45. 1% higher than that of the original strain, and the production rate was increased from 0. 45 to 0. 78 g/ ( L · h) .%以缺陷短波单胞菌(Brevundimonas diminuta)JNPP-1为出发菌株,利用紫外诱变及亚硝基胍复合诱变的方式,获得1株遗传性能稳定、可抗磺胺胍、能耐高渗透压以及能以琥珀酸钠为唯一C源的、在培养基上有生长优势的L-脯氨酸高产菌株JNPP-NSS( SGr、Sucg、NaClr).经发酵条件优化后,L-脯氨酸的最高质量浓度可达47.3 g/L,与出发菌株相比提高了45.1%,生产速率由0.45 g/(L·h)提高到0.78 g/(L·h).

  8. 33 CFR 157.11 - Pumping, piping and discharge arrangements.


    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Pumping, piping and discharge... CARRYING OIL IN BULK Design, Equipment, and Installation § 157.11 Pumping, piping and discharge arrangements. (a) Each tank vessel must have a fixed piping system for transferring oily mixtures from...

  9. 29 CFR 780.126 - Contract arrangements for raising poultry.


    ... 29 Labor 3 2010-07-01 2010-07-01 false Contract arrangements for raising poultry. 780.126 Section 780.126 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS EXEMPTIONS APPLICABLE TO AGRICULTURE, PROCESSING OF AGRICULTURAL...

  10. Parents' experiences of flexible work arrangements in changing European workplaces

    S. Lewis (Suzan); L. den Dulk (Laura)


    textabstractVarious leaves and other forms of flexible working arrangements have been implemented in workplaces to support employees with family commitments. Some are a response to public policy, others developed voluntarily. However, research examining the effectiveness of these policies in a searc

  11. Arrangement of library materials models in Slovene public libraries

    Marija Kobal


    Full Text Available The classification and the alignment of library material represent an important part of the library science from its early beginnings onwards. The introduction of UDC into Slovene public libraries coincided with the alteration of the open access library collection.In Slovenia the public libraries in average take into account the references and recommendations for the arrangement of the free access library collection, considering the age groups of the users, adults and juniors. The next division is connected with the functional type of the material, which is divided into fiction, and scientific material,and then there is the UDC label for the arrangement of the material on the shelves or word systematic in one of the public libraries. In the junior department there is a need for a further division into four age/reading groups of books instead of three.Within the formed groups there is the further arrangement of books in an alphabetical order by means of author or subject headings. The public library is a unit, which services all the residents in its local area. The different needs and interests of users should take into account in the formation of a library material arrangement.

  12. Flexible Work Arrangements: Accessibility in a University Environment

    Sharafizad, Fleur; Paull, Megan; Omari, Maryam


    Attraction and retention of highly qualified employees has become an area of concern for Australian universities. It has been suggested that flexible work arrangements can be utilised to achieve this goal once the factors affecting their uptake have been identified. This mixed-method study of 495 academic and general staff at an Australian…

  13. A taxonomy of management challenges for developing shared services arrangements

    Knol, A.J.; Janssen, M.F.W.H.A.; Sol, H.G.

    Shared service centres (SSCs) are an organisational arrangement to deliver services. During SSC development organisations encounter a variety of challenges affecting its success or failure. Yet in this embryonic research field a systematic insight into management challenges is absent. Drawing on

  14. Arrangement of collagen fibers in human placental stem villi

    Sati, Leyla; Demir, Ayse Yasemin; Sarikcioglu, Levent; Demir, Ramazan


    The aim of the study was to investigate the arrangements and related localization patterns of different collagen types in the stroma of placental stem villi by immunohistochemistry and electron microscopy. A total of 14 normal human term placental tissue samples were studied. Immunohistochemistry wa

  15. Arrangement of collagen fibers in human placental stem villi

    Sati, Leyla; Demir, Ayse Yasemin; Sarikcioglu, Levent; Demir, Ramazan


    The aim of the study was to investigate the arrangements and related localization patterns of different collagen types in the stroma of placental stem villi by immunohistochemistry and electron microscopy. A total of 14 normal human term placental tissue samples were studied. Immunohistochemistry

  16. Leaf arrangements are invalid in the taxonomy of orchid species

    Anna Jakubska-Busse


    Full Text Available The selection and validation of proper distinguishing characters are of crucial importance in taxonomic revisions. The modern classifications of orchids utilize the molecular tools, but still the selection and identification of the material used in these studies is for the most part related to general species morphology. One of the vegetative characters quoted in orchid manuals is leaf arrangement. However, phyllotactic diversity and ontogenetic changeability have not been analysed in detail in reference to particular taxonomic groups. Therefore, we evaluated the usefulness of leaf arrangements in the taxonomy of the genus Epipactis Zinn, 1757. Typical leaf arrangements in shoots of this genus are described as distichous or spiral. However, in the course of field research and screening of herbarium materials, we indisputably disproved the presence of distichous phyllotaxis in the species Epipactis purpurata Sm. and confirmed the spiral Fibonacci pattern as the dominant leaf arrangement. In addition, detailed analyses revealed the presence of atypical decussate phyllotaxis in this species, as well as demonstrated the ontogenetic formation of pseudowhorls. These findings confirm ontogenetic variability and plasticity in E. purpurata. Our results are discussed in the context of their significance in delimitations of complex taxa within the genus Epipactis.

  17. Love Matches and Arranged Marriages: A Chinese Replication.

    Xiaohe, Xu; Whyte, Martin King


    Partially replicated Japanese study by examining transition from arranged to free-choice marriages in Chinese ever-married women (n=586). The results revealed that the role of parents had declined sharply, whereas young people more and more dominated the process of mate selection. However there was still little sign of a "dating culture" emerging.…

  18. Spatial Arrangement in Texture Discrimination and Texture Segregation

    Kathleen Vancleef


    Full Text Available We investigated the role of spatial arrangement of texture elements in three psychophysical experiments on texture discrimination and texture segregation. In our stimuli, oriented Gabor elements formed an iso-oriented and a randomly oriented texture region. We manipulated (1 the orientation similarity in the iso-oriented region by adding orientation jitter to the orientation of each Gabor; (2 the spatial arrangement of the Gabors: quasi-random or regular; and (3 the shape of the edge between the two texture regions: straight or curved. In Experiment 1, participants discriminated an iso-oriented stimulus from a stimulus with only randomly oriented elements. Experiment 2 required texture segregation to judge the shape of the texture edge. Experiment 3 replicated Experiment 2 with Gabors of a smaller spatial extent in a denser arrangement. We found comparable performance levels with regular and quasi-random Gabor positions in the discrimination task but not in the segregation tasks. We conclude that spatial arrangement plays a role in a texture segregation task requiring shape discrimination of the texture edge but not in a texture discrimination task in which it is sufficient to discriminate an iso-oriented region from a completely random region.

  19. 40 CFR 265.37 - Arrangements with local authorities.


    ... (4) Arrangements to familiarize local hospitals with the properties of hazardous waste handled at the.... 265.37 Section 265.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE...

  20. BEPS Action 2: Neutralizing the Effects on Hybrid Mismatch Arrangements

    de Boer, R.; Marres, O.


    Curbing tax arbitrage is one of the main priorities of the Organization for Economic Cooperation and Development (OECD) (endorsed by the G20 and the G8) ever since the public debate on base erosion fully erupted. Neutralizing the effect of hybrid mismatch arrangements has become Action No. 2 of the

  1. Accountability after Structural Disaggregation: Comparing Agency Accountability Arrangements

    Overman, Sjors; Van Genugten, Marieke; Van Thiel, Sandra


    New accountability instruments – performance indicators, audits, and financial incentives – are expected to replace traditional accountability instruments in NPM reforms. We test this expectation by looking at the accountability arrangements of semi-autonomous agencies as a typical example of NPM re

  2. Interfacial re-arrangement in initial microbial adhesion to surfaces

    Busscher, Henk J.; Norde, Willem; Sharma, Prashant K.; van der Mei, Henny C.


    Upon initial microbial adhesion to a surface multiple events occur that include interfacial re-arrangements in the region between an adhering organism and a surface Application of physico-chemical mechanisms to explain microbial adhesion to surfaces requires better knowledge of the interfacial re ar

  3. 46 CFR 199.145 - Marine evacuation system launching arrangements.


    ...; (2) So it is capable of individual release from its stowage rack; (3) In accordance with the... and if necessary, is capable of being adjusted to the position required for evacuation. (b) Stowage... and platform, when deployed; its stowage container; and its operational arrangement must not...

  4. 46 CFR 108.545 - Marine evacuation system launching arrangements.


    ... capable of individual release from its stowage rack. (3) Each inflatable liferaft used in conjunction with...) Stowage. Each marine evacuation system must be stowed as follows: (1) There must not be any openings..., when deployed, its stowage container, and its operational arrangement must not interfere with...

  5. 46 CFR 133.145 - Marine evacuation system launching arrangements.


    ... individual release from its stowage rack. (3) Each inflatable liferaft used in conjunction with the marine... evacuation. (b) Stowage. Each marine evacuation system must be stowed as follows: (1) There must not be any... deployed; its stowage container; and its operational arrangement must not interfere with the operation...

  6. A taxonomy of management challenges for developing shared services arrangements

    Knol, A.J.; Janssen, M.F.W.H.A.; Sol, H.G.


    Shared service centres (SSCs) are an organisational arrangement to deliver services. During SSC development organisations encounter a variety of challenges affecting its success or failure. Yet in this embryonic research field a systematic insight into management challenges is absent. Drawing on lit

  7. 26 CFR 1.881-3 - Conduit financing arrangements.


    ... satisfaction of a repayment obligation is not an advance of money or other property. A financing arrangement... anticipated decline in the value of the property over its life. (2) Rate of tax. The rate at which tax is... the installment notes for FS. (ii) The C installment note now held by FS (as well as all of the...

  8. BEPS Action 2: Neutralizing the Effects on Hybrid Mismatch Arrangements

    de Boer, R.; Marres, O.


    Curbing tax arbitrage is one of the main priorities of the Organization for Economic Cooperation and Development (OECD) (endorsed by the G20 and the G8) ever since the public debate on base erosion fully erupted. Neutralizing the effect of hybrid mismatch arrangements has become Action No. 2 of the

  9. Parental Educational Involvement Conceived as the Arrangement of Contingency Operations

    Mellon, Robert C.; Moutavelis, Adrianos G.


    This study explored the utility of a conception of parental educational involvement as the arrangement of contingency operations that normatively change: the frequency of children's school-related behaviour, the reinforcing potency of stimuli produced by studying, and children's tendencies to request parental intervention. A child-report measure…

  10. Hexahedral mesh generation via the dual arrangement of surfaces

    Mitchell, S.A.; Tautges, T.J. [Sandia National Labs., Albuquerque, NM (United States)


    Given a general three-dimensional geometry with a prescribed quadrilateral surface mesh, the authors consider the problem of constructing a hexahedral mesh of the geometry whose boundary is exactly the prescribed surface mesh. Due to the specialized topology of hexahedra, this problem is more difficult than the analogous one for tetrahedra. Folklore has maintained that a surface mesh must have a constrained structure in order for there to exist a compatible hexahedral mesh. However, they have proof that a surface mesh need only satisfy mild parity conditions, depending on the topology of the three-dimensional geometry, for there to exist a compatible hexahedral mesh. The proof is based on the realization that a hexahedral mesh is dual to an arrangement of surfaces, and the quadrilateral surface mesh is dual to the arrangement of curves bounding these surfaces. The proof is constructive and they are currently developing an algorithm called Whisker Weaving (WW) that mirrors the proof steps. Given the bounding curves, WW builds the topological structure of an arrangement of surfaces having those curves as its boundary. WW progresses in an advancing front manner. Certain local rules are applied to avoid structures that lead to poor mesh quality. Also, after the arrangement is constructed, additional surfaces are inserted to separate features, so e.g., no two hexahedra share more than one quadrilateral face. The algorithm has generated meshes for certain non-trivial problems, but is currently unreliable. The authors are exploring strategies for consistently selecting which portion of the surface arrangement to advance based on the existence proof. This should lead us to a robust algorithm for arbitrary geometries and surface meshes.

  11. The Chloroplast Genome of Euglena mutabilis-Cluster Arrangement, Intron Analysis, and Intrageneric Trends.

    Dabbagh, Nadja; Preisfeld, Angelika


    A comparative analysis of the chloroplast genome of Euglena mutabilis underlined a high diversity in the evolution of plastids in euglenids. Gene clusters in more derived Euglenales increased in complexity with only a few, but remarkable changes in the genus Euglena. Euglena mutabilis differed from other Euglena species in a mirror-inverted arrangement of 12 from 15 identified clusters, making it very likely that the emergence at the base of the genus Euglena, which has been considered a long branch artifact, is truly a probable position. This was corroborated by many similarities in gene arrangement and orientation with Strombomonas and Monomorphina, rendering the genome organization of E. mutabilis in certain clusters as plesiomorphic feature. By RNA analysis exact exon-intron boundaries and the type of the 77 introns identified were mostly determined unambiguously. A detailed intron study of psbC pointed at two important issues: First, the number of introns varied even between species, and no trend from few to many introns could be observed. Second, mat1 was localized in Eutreptiales exclusively in intron 1, and mat2 was not identified. With the emergence of Euglenaceae in most species, a new intron containing mat2 inserted in front of the previous intron 1 and thereby became intron 2 with mat1.

  12. Effects of Magnetic Particles Entrance Arrange-ments on Mixing Efficiency of a Magnetic Bead Micromixer

    Reza Kamali∗; Seyed Alireza Shekoohi; Alireza Binesh


    In this study, a computer code is developed to numerically investigate a magnetic bead micromixer under different conditions. The micromixer consists of a microchannel and numerous micro magnetic particles which enter the micromixer by fluid flows and are actuated by an alternating magnetic field normal to the main flow. An important feature of micromixer which is not considered before by researchers is the particle entrance arrangement into the micromixer. This parameter could effectively affect the micromixer efficiency. There are two general micro magnetic particle entrance arrangements in magnetic bead micromixers: determined position entrance and random position entrance. In the case of determined position entrances, micro magnetic particles enter the micromixer at specific positions of entrance cross section. However, in a random position entrance, particles enter the microchannel with no order. In this study mixing efficiencies of identical magnetic bead micromixers which only differ in particle entrance arrangement are numerically investigated and compared. The results reported in this paper illustrate that the prepared computer code can be one of the most powerful and beneficial tools for the magnetic bead micromixer performance analysis. In addition, the results show that some features of the magnetic bead micromixer are strongly affected by the entrance arrangement of the particles.

  13. Mitochondrial rRNA secondary structures and genome arrangements distinguish chelicerates: comparisons with a harvestman (Arachnida: Opiliones: Phalangium opilio).

    Masta, Susan E


    Arachnids are a highly diverse group of arthropods, and many of the mitochondrial genomes that have been sequenced from arachnids possess unusual features in their inferred gene structures and genome organization. The first complete sequence of a mitochondrial genome from the arachnid order Opiliones (harvestmen) is presented here. Secondary structures of the two mitochondrial ribosomal subunits of Phalangium opilio are inferred and compared to mitochondrial rRNA structures of a hexapod and a chelicerate. The large subunit rRNA of P. opilio is found to have more helices conserved than in other arthropods, while the small subunit rRNA shows a complexity similar to that of other arthropods. These comparisons suggest that a reduction in rRNA complexity occurred in Pancrustacea after the divergence of Pancrustacea and Chelicerata from a common ancestor. The gene arrangement of the mitochondrial genome of P. opilio is compared with the gene order of taxa from all seven other orders of arachnids for which representative mitochondrial genomes have been sequenced. Taxa from five of these seven orders possess gene arrangements identical to that of Limulus polyphemus, and P. opilio is found to have a similar arrangement. However, in P. opilio, some genes near the putative control region are rearranged, with the suite of genes encoding tRNA(Gln), the control region, and tRNA(Ile) located downstream of the two ribosomal RNA genes, and upstream of where they are typically located in chelicerates. The genome encodes only 21 of the typical 22 mitochondrial tRNA genes and lacks the gene for tRNA(Leu(CUN)). The protein-coding genes in the mitochondrial genome of P. opilio show a significantly decreased use of codons recognized by tRNA(Leu(CUN)), likely due to selection to utilize the more specific tRNA(Leu(UUR)) anticodon. The gene arrangement and lack of a tRNA(Leu(CUN)) gene in P. opilio is most parsimoniously explained by the occurrence of at least two translocation events, one

  14. Quantum Integrable Model of an Arrangement of Hyperplanes

    Alexander Varchenko


    Full Text Available The goal of this paper is to give a geometric construction of the Bethe algebra (of Hamiltonians of a Gaudin model associated to a simple Lie algebra. More precisely, in this paper a quantum integrable model is assigned to a weighted arrangement of affine hyperplanes. We show (under certain assumptions that the algebra of Hamiltonians of the model is isomorphic to the algebra of functions on the critical set of the corresponding master function. For a discriminantal arrangement we show (under certain assumptions that the symmetric part of the algebra of Hamiltonians is isomorphic to the Bethe algebra of the corresponding Gaudin model. It is expected that this correspondence holds in general (without the assumptions. As a byproduct of constructions we show that in a Gaudin model (associated to an arbitrary simple Lie algebra, the Bethe vector, corresponding to an isolated critical point of the master function, is nonzero.

  15. Experimental arrangement to measure dispersion in optical fiber devices

    Armas Rivera, Ivan [Benemerita Universidad Autonoma de Puebla, Facultad de Ciencias de la Electronica (Mexico); Beltran Perez, Georgina; Castillo Mixcoatl, Juan; Munoz Aguirre, Severino [Benemerita Universidad Autonoma de Puebla, Facultad de Ciencias Fisico Matematicas (Mexico); Zaca Moran, Placido, E-mail: [Benemerita Universidad Autonoma de Puebla, Fisicoquimica de Materiales ICUAP (Mexico)


    Dispersion is a quite important parameter in systems based on optical fiber, especially in pulsed emission lasers, where the temporal width is affected by such parameter. Therefore, it is necessary to consider the dispersion provoked by each component in the cavity. There are various experimental interferometric arrangements to evaluate this parameter. Generally, these systems modify the wavelength to obtain information about the n({lambda}) dependency, which is contained in the interferogram phase. However, this makes the system quite slow and it requires tunable and narrow bandwidth laser sources. In the present work, results obtained from an arrangement based on Mach-Zehnder interferometer where one of the arms is the optical fiber under study, while the reference one is air, are presented. In order to determine the n({lambda}) dependency, a wide spectrum light source was used in the wavelength range of interest. The phase information was evaluated from the interferometric signal measured by an optical spectrum analyzer.

  16. Innovative Nuclear Power Plant Building Arrangement in Consideration of Decommissioning

    Won-Jun Choi


    Full Text Available A new concept termed the Innovative Nuclear Power Plant Building Arrangement (INBA strategy is a new nuclear power plant building arrangement method which encompasses upfront consideration of more efficient decommissioning. Although existing decommissioning strategies such as immediate dismantling and differed dismantling has the advantage of either early site restoration or radioactive decommissioning waste reduction, the INBA strategy has the advantages of both strategies. In this research paper, the concept and the implementation method of the INBA strategy will be described. Two primary benefits will be further described: (1 early site restoration; and (2 radioactive waste reduction. Several other potential benefits will also be identified. For the estimation of economic benefit, the INBA strategy, with two primary benefits, will be compared with the immediate dismantling strategy. The effect of a short life cycle nuclear power plant in combination with the INBA strategy will be reviewed. Finally, some of the major impediments to the realization of this strategy will be discussed.

  17. Control arrangement for the actuation of hydraulic consumers

    Kussel, W.; Dettmers, M.; Weirich, W.


    An arrangement for controlling the actuation of hydraulic consumers, by selectively connecting the consumers to hydraulic pressure and return lines; the control arrangement comprising a respective hydraulically operated directional control valve associated with each of the hydraulic consumers, a respective electro-magnetically operated pre-control valve associated with each of the hydraulic directional control valves, and further electro-magnetically operated directional control valve means associated with the pre-control valves, each of the hydraulic consumers being connectible to the hydraulic pressure or return lines via the associated hydraulically operated directional control valve which is actuatable by a hydraulic control line leading from the output of the associated pre-control valve, wherein the inputs of the pre-control valves are connected directly to the hydraulic return line and indirectly, via the further control valve means, to the hydraulic return line or to a hydraulic control pressure line.

  18. Reactive Scattering Wave Functions by Linear Combination of Arrangement Channels

    邓从豪; 冯大诚; 蔡政亭


    The similarity and dissimilarity of reactive scattering wave functions and molecular orbitalby linear combination of atomic orbitals(LCAOMO)are examined.Based on the similarity a method is pro-posed to construct the reactive scattering wave functions by linear combination of arrangement channel wavefunctions(LCACSW).Based on the dissimilarity,it is shown that the combination coefficients can be deter-mined by solving s set of simultaneous algebraic equations.The elements of the reactive scattering matrix areshown to be related to the combination coefficients of open arrangement channels.The differential and totalreactive scattering cross-section derived by this method agrees completely with that derived by other meth-ods.

  19. On the topology of the world exchange arrangements web

    Li, Xiang; Jin, Yu Ying; Chen, Guanrong


    Exchange arrangements among different countries over the world are foundations of the world economy, which generally stand behind the daily economic evolution. As the first study of the world exchange arrangements web (WEAW), we built a bipartite network with countries as one type of nodes and currencies as the other, and found it to have a prominent scale-free feature with a power-law degree distribution. In a further empirical study of the currency section of the WEAW, we calculated the clustering coefficients, average nearest-neighbors degree, and average shortest distance. As an essential economic network, the WEAW is found to be a correlated disassortative network with a hierarchical structure, possessing a more prominent scale-free feature than the world trade web (WTW).

  20. On the topology of the world exchange arrangements web

    Chen, X L


    Exchange arrangements among different countries over the world are foundations of the world economy, which generally stand behind the daily economic evolution. As the first study of the world exchange arrangements web (WEAW), we built a bipartite network with countries as one type of nodes and currencies as the other, and found it to have a prominent scale-free feature with a power-law degree distribution. In a further empirical study of the currency section of the WEAW, we calculated the clustering coefficients, average nearest-neighbors degree, and average shortest distance. As an essential economic network, the WEAW is found to be a correlated disassortative network with a hierarchical structure, possessing a more prominent scale-free feature than the world trade web (WTW).

  1. A large scale cryopanel test arrangement for tritium pumping

    Day, Chr. E-mail:; Brennan, D.; Jensen, H.S.; Mack, A


    A cryosorption panel test arrangement will be installed in the cryogenic forevacuum system of the Active Gas Handling System (AGHS) at Joint European Torus (JET). The panel is of International Thermonuclear Experimental Reactor (ITER) relevant design in terms of geometry and dimension, coating and sorbent material. The central objective of this task is to study, for the first time in such an in-depth and parametric way, the interaction of tritium and tritiated gas mixtures with the panel, with respect to pumping performance, desorption characteristics and structural influences. This paper describes the motivation for this task and outlines the experimental aims and how they are planned to be achieved. It presents the actual status and gives a description of the test arrangement design. The paper demonstrates how the AGHS is used as a unique benchmark test bed for an ITER component to qualify ITER tritium technology.

  2. Arrangement scheme of a semi-parallel ventilation system

    Konoplev, E.S.; Sharf, V.G.; Timukhin, S.A.


    This paper evaluates a version of the system with two parallel blowers. The system is used for blowing ventilation in coal and other mines. In the modified version the two blowers are not parallel but are inclined. Air channels which supply air to the blowers have a circular rather than square crosscut. Blower arrangement and shape of air channels are shown in two schemes. Comparative evaluations of the aerodynamic resistance of the half parallel blower system with two VOD 30 blowers show that resistance of the air channels which supply air to the blowers is reduced to 0.23. A calculation method for determining aerodynamic resistance of air channels in the systems of the semi-parallel blower system considering air channel shape, dimensions, arrangement and position of two blowers is presented. Examples of practical use of the method are discussed.

  3. Minimum cell connection and separation in line segment arrangements

    Alt, Helmut; Giannopoulos, Panos; Knauer, Christian


    We study the complexity of the following cell connection and separation problems in segment arrangements. Given a set of straight-line segments in the plane and two points a and b: (i) compute the minimum number of segments one needs to remove so that there is a path connecting a to b that does not intersect any of the remaining segments; (ii) compute the minimum number of segments one needs to remove so that the arrangement induced by the remaining segments has a single cell; (iii) compute the minimum number of segments one needs to retain so that any path connecting a to b intersects some of the retained segments. We show that problems (i) and (ii) are NP-hard, while problem (iii) is polynomial-time solvable. We also discuss special polynomial-time and fixed-parameter tractable cases.

  4. Arrangement of peptidoglycan in the cell wall of Staphylococcus spp.

    Amako, K.; Umeda, A; Murata, K


    The arrangement of peptidoglycan in the cell wall of Staphylococcus was observed with the newly developed freeze-fracture technique, using n-octanol instead of water as the freezing medium. The replica of the trichloroacetic acid-extracted cell wall (TCA-wall) showed two areas. One of them has a concentric circular structure, a characteristic surface structure of the staphylococcal cell wall, and the other showed an irregular and rough surface. The chemical analysis of the wall revealed that ...

  5. Arrangements, multiderivations, and adjoint quotient map of type ADE

    Yoshinaga, Masahiko


    The first part of this paper is a survey on algebro-geometric aspects of sheaves of logarithmic vector fields of hyperplane arrangements. In the second part we prove that the relative de Rham cohomology (of degree two) of ADE-type adjoint quotient map is naturally isomorphic to the module of certain multiderivations. The isomorphism is obtained by the Gauss-Manin derivative of the Kostant-Kirillov form.

  6. Small-Firm Networks: hybrid arrangement or organizational form?

    Verschoore,Jorge Renato; Balestrin,Alsones; Perucia,Alexandre


    In the field of organizations, one relevant question is whether or not to consider networks as organizational forms. On the one hand, Williamson (1985) says that networks are hybrid arrangements. On the other, authors like Powell (1990) argue that networks constitute themselves as organizational forms. Given this dilemma, the present article proposes the analysis of organizational characteristics of small-firm networks (SFN). To reach such objective, twelve SFNs in distinct stages of developm...

  7. Refrigeration arrangement and methods for reducing charge migration

    Litch, Andrew D.; Wu, Guolian


    A refrigerator appliance including a refrigerant circuit between a condenser, an evaporator, and a compressor that includes two conduits and pressure reducing devices arranged in parallel between the evaporator and the condenser. The appliance also includes a valve system to direct refrigerant through one, both or none of the conduits and pressure reducing devices, and a heat exchanging member in thermal contact with either one pressure reducing device, or one conduit between the pressure reducing device and the valve system.

  8. Golden spirals as phyllotactic arrangements of optical patterns.

    Haudin, F; Residori, S


    A nonlinear optical medium with nonlocal feedback is shown to have all the necessary ingredients to simulate a growthlike process that generates golden spirals and phyllotactic patterns. Elementary droplets of light are generated by the optical nonlinearity whereas the combination of rotation and translation in the feedback loop geometrically distributes them on spiraling patterns. The symmetry of the geometrical arrangements is described with the help of a simple replication algorithm.

  9. Implementation of an Arranged Preventive Consultation in Danish General Practice

    Junge, Anne Gram; Kirkegaard, Pia; Thomsen, Janus Laust

    Background: In 2006 an arranged preventive consultation (0106-service) was implemented in Danish general practice. The purpose of the consultation is an attempt to improve the systematic prevention of the main chronic lifestyle diseases. Aim: This study examines the GP's experiences with the arra...... interaction between the GP/nurse and the patient, and therefore the GPs/nurses can in some respects experience it as difficult to apply the theoretical guidelines of the new consultation to their daily work with the patients.......Background: In 2006 an arranged preventive consultation (0106-service) was implemented in Danish general practice. The purpose of the consultation is an attempt to improve the systematic prevention of the main chronic lifestyle diseases. Aim: This study examines the GP's experiences...... with the arranged preventive consultation with focus on facilitators and barriers in the implementation of the consultation. Material & Method: Semi-structured interviews with 10 GPs and nurses in general practice. Results & Conclusions: Economically lucrative services are not an isolated motivation for the GPs...

  10. Studies on optimal design and operation of integrated distillation arrangements

    Christiansen, Atle Christer


    During the last decades, there has been growing concern in the chemical engineering environment over the task of developing more cost- and energy efficient process equipment. This thesis discusses measures for improving the end-use energy efficiency of separation systems. It emphasises a certain class of integrated distillation arrangements, in particular it considers means for direct coupling of distillation columns so as to use the underlying physics to facilitate more energy efficient separations. The numerical methods discussed are well suited to solve models of distillation columns. A tear and grid method is proposed that to some extent exploits the sparsity, since the number of tear variables required for solving a distillation model usually is rather small. The parameter continuation method described is well suited for ill-conditioned problems. The analysis of integrated columns is extended beyond the scope of numerical simulations by means of analytical results that applies in certain limiting cases. The consept of preferred separation, which is important for prefractionator arrangements, is considered. From this analysis is derived information that is important for the practical operation of such columns. Finally, the proposed numerical methods are used to optimize Petlyuk arrangements for separating ternary and quaternary mixtures. 166 refs., 130 figs., 20 tabs.

  11. Review of arrangements for the recent transportation of radioactive waste

    Codd, M.H.


    The terms of reference of this review were: to examine the adequacy of the arrangements made for the transport of contaminated material from Lucas Heights and St Marys to Woomera, in terms of compliance with the Australian Code for the Safe Transport of Radioactive Substances 1990; to report to the Minister for Industry, Science and Technology on the quality of the planning and preparation for the move; the safety and effectiveness of the move itself; the adequacy of response to any `incidents` involved in the move, and of contingency arrangements; whether planning and transport arrangements might be improved for the future. Thus, the Review was focussed on movements of material in two specific cases - material owned by the CSIRO and stored at Lucas Heights and material owned by the Department of Defence and stored at St Marys. The report concludes that the movements of wastes were carried out consistent with the Transport Code, without any risk to public safety. Additional relevant information in support of the review is contained in 8 appendixes.

  12. Elastic properties of nematoid arrangements formed by amoeboid cells

    Kemkemer, R.; Kling, D.; Kaufmann, D.; Gruler, H.


    In culture migrating and interacting amoeboid cells can form nematoid arrangements in analogy to a nematic liquid crystal phase. A nematoid arrangement is formed if the interaction has an apolar symmetry. Different cell types like human melanocytes (=pigment cells of the skin), human fibroblasts (=connective tissue cells), human osteoblasts (=bone cells), human adipocytes (=fat cells) etc., form a nematoid structure. Our hypothesis is that elastic properties of these nematoid structures can be described in analogy to that of classical nematic liquid crystals. The orientational elastic energy is derived and the orientational defects (disclination) of nematoid arrangements are investigated. The existence of half-numbered disclinations shows that the nematoid structure has an apolar symmetry. The density- and order parameter dependence of the orientational elastic constants and their absolute values are estimated. From the defect structure, one finds that the splay elastic constant is smaller than the bend elastic constant (melanocytes). The core of a disclination is either a cell free space or occupied by non oriented cells (isotropic state), by a cell with a different symmetry, or by another cell type.

  13. Intergenerational living arrangements in Myanmar and Thailand: a comparative analysis.

    Knodel, John; Pothisiri, Wiraporn


    The present study compares living arrangements and related intergenerational support in Myanmar and Thailand based on recent national surveys of older persons in both countries and prior surveys in Thailand. The countries share relatively similar cultural contexts but differ radically in economic development. Substantially higher percentages of older persons in Myanmar currently coreside with their children and are considerably more likely to have non-coresident children living in the same locality. They are also less likely to live with a spouse and to have children living at a substantial distance. Older persons in Myanmar are much less likely to have phone contact with children living away and less likely to receive visits. Thai elders are considerably more likely to provide custodial care to grandchildren with absent parents and to live in skip generation households. Older Thais are also considerably more likely to receive substantial remittances from non-coresident children. The living arrangements of older age Thais in the past, however, more closely resembles the current situation in Myanmar. It appears that current differences are largely attributable to the more advanced Thai economic development through its associated impacts on migration, fertility and mortality. Contrasting political situations and government priorities also likely play a role. The results provide insights into the implications of development for older persons and suggest that if the recent course of political transformation and opening to the global economy continues in Myanmar, living arrangements there may well follow the trends in Thailand over past decades.

  14. Collaborative arrangements for Australian nurse practitioners: a policy analysis.

    Cashin, Andrew


    In Australia in 2010, nurse practitioners (NPs) were granted legislated access to the Medical Benefits Scheme (MBS) and Pharmaceutical Benefits Scheme (PBS) as providers. These schemes are the federal schemes for third-party reimbursement for health care and medications. As a condition of access to the schemes, it was determined that collaborative arrangements needed to be in place as part of eligibility criteria for NPs. This article is the first published policy analysis of this determination. Published literature and available grey literature (including meeting minutes), and media content, was accessed and analyzed. The policy that was the National Health Collaborative arrangements for Nurse Practitioners Determination to amend the Australian National Health Act 1953 was a success. The policy led to NP access as providers to the MBS and PBS in Australia. Understanding the policy process as it relates to the determination of the need for collaborative arrangements demystifies the process and origins of the policy for NPs in Australia. Understanding the determination means NPs in Australia will not artificially reduce scope of practice based on recommendations from the medical lobby. Clear research direction is provided that may inform the next policy cycle. ©2014 American Association of Nurse Practitioners.

  15. Systems-level chromosomal parameters represent a suprachromosomal basis for the non-random chromosomal arrangement in human interphase nuclei

    Fatakia, Sarosh N.; Mehta, Ishita S.; Rao, Basuthkar J.


    Forty-six chromosome territories (CTs) are positioned uniquely in human interphase nuclei, wherein each of their positions can range from the centre of the nucleus to its periphery. A non-empirical basis for their non-random arrangement remains unreported. Here, we derive a suprachromosomal basis of that overall arrangement (which we refer to as a CT constellation), and report a hierarchical nature of the same. Using matrix algebra, we unify intrinsic chromosomal parameters (e.g., chromosomal length, gene density, the number of genes per chromosome), to derive an extrinsic effective gene density matrix, the hierarchy of which is dominated largely by extrinsic mathematical coupling of HSA19, followed by HSA17 (human chromosome 19 and 17, both preferentially interior CTs) with all CTs. We corroborate predicted constellations and effective gene density hierarchy with published reports from fluorescent in situ hybridization based microscopy and Hi-C techniques, and delineate analogous hierarchy in disparate vertebrates. Our theory accurately predicts CTs localised to the nuclear interior, which interestingly share conserved synteny with HSA19 and/or HSA17. Finally, the effective gene density hierarchy dictates how permutations among CT position represents the plasticity within its constellations, based on which we suggest that a differential mix of coding with noncoding genome modulates the same. PMID:27845379

  16. The diffeomorphic types of the complements of arrangements in CP3 Ⅱ

    WANG ShaoBo; YAU Stephen S-T


    For any arrangement of hyperplanes in CP3,we introduce the soul of this arrangement.The soul,which is a pseudo-complex,is determined by the combinatorics of the arrangement of hyper- planes.In this paper,we give a sufficient combinatoric condition for two arrangements of hyperplanes to be diffeomorphic to each other.In particular we have found sufficient conditions on combinatorics for the arrangement of hyperplanes whose moduli space is connected.This generalizes our previous result on hyperplane point arrangements in CP3.

  17. The diffeomorphic types of the complements of arrangements in CP~3Ⅱ

    YAU; Stephen; S-T


    For any arrangement of hyperplanes in CP~3,we introduce the soul of this arrangement. The soul,which is a pseudo-complex,is determined by the combinatorics of the arrangement of hyper- planes.In this paper,we give a sufficient combinatoric condition for two arrangements of hyperplanes to be diffeomorphic to each other.In particular we have found sufficient conditions on combinatorics for the arrangement of hyperplanes whose moduli space is connected.This generalizes our previous result on hyperplane point arrangements in CP~3.

  18. Zoned electrical heater arranged in spaced relationship from particulate filter

    Gonze, Eugene V [Pinckney, MI


    A system comprises a particulate matter (PM) filter that comprises an upstream end for receiving exhaust gas and a downstream end. A zoned heater is arranged spaced from the upstream end and comprises N zones, where N is an integer greater than one, wherein each of the N zones comprises M sub-zones, where M is an integer greater than one. A control module selectively activates at least a selected one of the N zones to initiate regeneration in downstream portions of the PM filter from the one of the N zones and deactivates non-selected ones of the N zones.

  19. Engine Power Turbine and Propulsion Pod Arrangement Study

    Robuck, Mark; Zhang, Yiyi


    A study has been conducted for NASA Glenn Research Center under contract NNC10BA05B, Task NNC11TA80T to identify beneficial arrangements of the turboshaft engine, transmissions and related systems within the propulsion pod nacelle of NASA's Large Civil Tilt-Rotor 2nd iteration (LCTR2) vehicle. Propulsion pod layouts were used to investigate potential advantages, disadvantages, as well as constraints of various arrangements assuming front or aft shafted engines. Results from previous NASA LCTR2 propulsion system studies and tasks performed by Boeing under NASA contracts are used as the basis for this study. This configuration consists of two Fixed Geometry Variable Speed Power Turbine Engines and related drive and rotor systems (per nacelle) arranged in tilting nacelles near the wing tip. Entry-into-service (EIS) 2035 technology is assumed for both the engine and drive systems. The variable speed rotor system changes from 100 percent speed for hover to 54 percent speed for cruise by the means of a two speed gearbox concept developed under previous NASA contracts. Propulsion and drive system configurations that resulted in minimum vehicle gross weight were identified in previous work and used here. Results reported in this study illustrate that a forward shafted engine has a slight weight benefit over an aft shafted engine for the LCTR2 vehicle. Although the aft shafted engines provide a more controlled and centered CG (between hover and cruise), the length of the long rotor shaft and complicated engine exhaust arrangement outweighed the potential benefits. A Multi-Disciplinary Analysis and Optimization (MDAO) approach for transmission sizing was also explored for this study. This tool offers quick analysis of gear loads, bearing lives, efficiencies, etc., through use of commercially available RomaxDESIGNER software. The goal was to create quick methods to explore various concept models. The output results from RomaxDESIGNER have been successfully linked to Boeing

  20. Make or buy: HMOs' contracting arrangements for mental health care.

    Hodgkin, D; Horgan, C M; Garnick, D W


    Many health maintenance organizations (HMOs) are contracting with external vendors for mental health care, rather than maintaining an internal mental health department. We develop a framework for analyzing HMOs' contracting choices, rooted in transaction cost economics. Applying this framework, external contracting seems most likely to appeal to smaller, newer HMOs and those located in areas with multiple vendors. Pressure from value-oriented buyers may make it harder for HMOs to provide mental health internally, without costly reforms to their product. HMO contracting arrangements deserve further study, given their implications for cost and the quality of care.

  1. TrayGen: Arranging objects for exhibition and packaging

    Yang, Yongliang


    We present a framework, called TrayGen, to generate tray designs for the exhibition and packaging of a collection of objects. Based on principles from shape perception and visual merchandising, we abstract a number of design guidelines on how to organize the objects on the tray for the exhibition of their individual features and mutual relationships. Our framework realizes these guidelines by analyzing geometric shapes of the objects and optimizing their arrangement. We demonstrate that the resultant tray designs not only save space, but also highlight the characteristic of each object and the inter-relations between objects. © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  2. Novel Arrangements for High Performance and Durable Dielectric Elastomer Actuation

    Runan Zhang


    Full Text Available This paper advances the design of Rod Pre-strained Dielectric Elastomer Actuators (RP-DEAs in their capability to generate comparatively large static actuation forces with increased lifetime via optimized electrode arrangements. RP-DEAs utilize thin stiff rods to constrain the expansion of the elastomer and maintain the in-plane pre-strain in the rod longitudinal direction. The aim is to study both the force output and the durability of the RP-DEA. Initial design of the RP-DEA had poor durability, however, it generated significantly larger force compared with the conventional DEA due to the effects of pre-strain and rod constraints. The durability study identifies the in-electro-active-region (in-AR lead contact and the non-uniform deformation of the structure as causes of pre-mature failure of the RP-DEA. An optimized AR configuration is proposed to avoid actuating undesired areas in the structure. The results show that with the optimized AR, the RP-DEA can be effectively stabilized and survive operation at least four times longer than with a conventional electrode arrangement. Finally, a Finite Element simulation was also performed to demonstrate that such AR design and optimization can be guided by analyzing the DEA structure in the state of pre-activation.

  3. Exhaust hood for steam turbines-single-flow arrangement

    Michal HOZNEDL; Ladislav TAJC; Jaroslav KREJCIK; Lukas BEDNAR; Kamil SEDLAK; Jiri LINHART


    In the past, increased attention was given to the development of an optimal shape for the inlet part of LP turbine casings in SKODA POWER. A double-flow design is typically used for high power output turbines. An optimized shape for the internal diffuser has been found,which transforms the kinetic energy of steam into increased pressure, thus effectively increasing the thermo-dynamic efficiency of the stage. Some conclusions have been drawn from laboratory experiments, others derived directly from on-site measurements at power plants. The conclusions from the development of double-flow turbines form the basis for the design of the single-flow turbine arrangement. Single-flow design is typically used for lower output turbines. There are still some limitations in applying this arrangement. The designer needs to resolve the bearing position and how to ensure access to them. Reinforcing the ribs and supports are used, therefore, to ensure the rigidity of the entire casing. The optimization of the single-flow diffuser shape is therefore the subject of the study presented below.

  4. Similar Sister Chromatid Arrangement in Mono- and Holocentric Plant Chromosomes.

    Schubert, Veit; Zelkowski, Mateusz; Klemme, Sonja; Houben, Andreas


    Due to the X-shape formation at somatic metaphase, the arrangement of the sister chromatids is obvious in monocentric chromosomes. In contrast, the sister chromatids of holocentric chromosomes cannot be distinguished even at mitotic metaphase. To clarify their organization, we differentially labelled the sister chromatids of holocentric Luzula and monocentric rye chromosomes by incorporating the base analogue EdU during replication. Using super-resolution structured illumination microscopy (SIM) and 3D rendering, we found that holocentric sister chromatids attach to each other at their contact surfaces similar to those of monocentrics in prometaphase. We found that sister chromatid exchanges (SCEs) are distributed homogeneously along the whole holocentric chromosomes of Luzula, and that their occurrence is increased compared to monocentric rye chromosomes. The SCE frequency of supernumerary B chromosomes, present additionally to the essential A chromosome complement of rye, does not differ from that of A chromosomes. Based on these results, models of the sister chromatid arrangement in mono- and holocentric plant chromosomes are presented.

  5. Infant Sleeping Arrangements and Cultural Values among Contemporary Japanese Mothers

    Mina eShimizu


    Full Text Available We examined infant sleeping arrangements and parenting ethnotheories of Japanese mothers in 2008 and 2009. Based on Greenfield's theory of social change and human development, we predicted that social change in Japan over the last decades (higher economic and education level, urbanization, complex technology, more women in the work force would lead to a decline in mother-infant cosleeping, compared with published findings concerning Japanese sleeping arrangements in the 1960s and 1980s. We also predicted that the practice of having babies sleep in their own beds and/or own rooms would be supported by ethnotheories stressing infant independence and other values adaptive in an urban, technologically sophisticated, relatively wealthy, and highly educated populace. Fifty-one Japanese mothers’ comments posted on Internet parenting forums were analyzed. Contrary to our hypothesis, cosleeping was as frequent among Japanese mothers in 2008-2009 as it had been in the 1960s and 1980s. However, analysis of the values of cosleeping mothers revealed frequent discrepancies between values and practices. In contrast, the minority of mothers whose babies slept alone in a separate room all expressed consonant ethnotheories. Our qualitative analysis indicates that it is not always easy for Japanese mothers to construct values for child rearing and gender roles that integrate traditional infant care practices with current sociodemographic conditions.

  6. Tetrahedral Arrangements of Perylene Bisimide Columns via Supramolecular Orientational Memory.

    Sahoo, Dipankar; Peterca, Mihai; Aqad, Emad; Partridge, Benjamin E; Heiney, Paul A; Graf, Robert; Spiess, Hans W; Zeng, Xiangbing; Percec, Virgil


    Chiral, shape, and liquid crystalline memory effects are well-known to produce commercial macroscopic materials with important applications as springs, sensors, displays, and memory devices. A supramolecular orientational memory effect that provides complex nanoscale arrangements was only recently reported. This supramolecular orientational memory was demonstrated to preserve the molecular orientation and packing within supramolecular units of a self-assembling cyclotriveratrylene crown at the nanoscale upon transition between its columnar hexagonal and Pm3̅n cubic periodic arrays. Here we report the discovery of supramolecular orientational memory in a dendronized perylene bisimide (G2-PBI) that self-assembles into tetrameric crowns and subsequently self-organizes into supramolecular columns and spheres. This supramolecular orientation memory upon transition between columnar hexagonal and body-centered cubic (BCC) mesophases preserves the 3-fold cubic [111] orientations rather than the 4-fold [100] axes, generating an unusual tetrahedral arrangement of supramolecular columns. These results indicate that the supramolecular orientational memory concept may be general for periodic arrays of self-assembling dendrons and dendrimers as well as for other periodic and quasiperiodic nanoscale organizations comprising supramolecular spheres, generated from other organized complex soft matter including block copolymers and surfactants.

  7. Numerical simulation of bionic foils in tandem arrangement

    Kai Zhou


    Full Text Available Based on the backgrounds of underwater propulsors with high hydrodynamic performance, the article focuses on the flapping foils in tandem arrangement and tries to formulate the physical mode and mathematical model of flapping propulsion. Using the commercial software Fluent, the governing equations are discretized by the finite volume method, and dynamic mesh method is adopted to solve the moving boundaries. In order to verify validity and feasibility of the method, hydrodynamic performance of single flapping foil is analyzed. The present results of single flapping foil compare well with those in experimental researches. After that, numerical simulations of flapping foils in tandem arrangement are conducted to reveal the energy absorption mechanisms. By extracting performance parameters and characteristics of the flow field, the interaction between upstream foil and downstream foil is analyzed. The results indicate that the vortices shedding from upstream foil have a significant effect on the hydrodynamic performance of downstream foil, and the downstream foil can use energy from the flow field to improve the hydrodynamic performance. Therefore, the hydrodynamic performance of the system can be improved by adjusting the locations of foils and motion parameters.

  8. Factors affecting daughter cells' arrangement during the early bacterial divisions.

    Pin-Tzu Su

    Full Text Available On agar plates, daughter cells of Escherichia coli mutually slide and align side-by-side in parallel during the first round of binary fission. This phenomenon has been previously attributed to an elastic material that restricts apparently separated bacteria from being in string. We hypothesize that the interaction between bacteria and the underneath substratum may affect the arrangement of the daughter bacteria. To test this hypothesis, bacterial division on hyaluronic acid (HA gel, as an alternative substratum, was examined. Consistent with our proposition, the HA gel differs from agar by suppressing the typical side-by-side alignments to a rare population. Examination of bacterial surface molecules that may contribute to the daughter cells' arrangement yielded an observation that, with disrupted lpp, the E. coli daughter cells increasingly formed non-typical patterns, i.e. neither sliding side-by-side in parallel nor forming elongated strings. Therefore, our results suggest strongly that the early cell patterning is affected by multiple interaction factors. With oscillatory optical tweezers, we further demonstrated that the interaction force decreased in bacteria without Lpp, a result substantiating our notion that the side-by-side sliding phenomenon directly reflects the strength of in-situ interaction between bacteria and substratum.

  9. Analysis of the Complete Mycoplasma hominis LBD-4 Genome Sequence Reveals Strain-Variable Prophage Insertion and Distinctive Repeat-Containing Surface Protein Arrangements


    The complete genome sequence of Mycoplasma hominis LBD-4 has been determined and the gene content ascribed. The 715,165-bp chromosome contains 620 genes, including 14 carried by a strain-variable prophage genome related to Mycoplasma fermentans MFV-1 and Mycoplasma arthritidis MAV-1. Comparative analysis with the genome of M. hominis PG21T reveals distinctive arrangements of repeat-containing surface proteins.

  10. Analysis of the Complete Mycoplasma hominis LBD-4 Genome Sequence Reveals Strain-Variable Prophage Insertion and Distinctive Repeat-Containing Surface Protein Arrangements.

    Calcutt, Michael J; Foecking, Mark F


    The complete genome sequence of Mycoplasma hominis LBD-4 has been determined and the gene content ascribed. The 715,165-bp chromosome contains 620 genes, including 14 carried by a strain-variable prophage genome related to Mycoplasma fermentans MFV-1 and Mycoplasma arthritidis MAV-1. Comparative analysis with the genome of M. hominis PG21(T) reveals distinctive arrangements of repeat-containing surface proteins.

  11. 78 FR 31943 - Draft Guidance for Industry on Contract Manufacturing Arrangements for Drugs: Quality Agreements...


    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Contract Manufacturing... guidance for industry entitled ``Contract Manufacturing Arrangements for Drugs: Quality Agreements.'' This... draft guidance for industry entitled ``Contract Manufacturing Arrangements for Drugs: Quality...

  12. Complete mitochondrial genome of Camponotus atrox (Hymenoptera: Formicidae): a new tRNA arrangement in Hymenoptera.

    Kim, Min Jee; Hong, Eui Jeong; Kim, Iksoo


    We sequenced the complete mitochondrial (mt) genome of Camponotus atrox (Hymenoptera: Formicidae), which is only distributed in Korea. The genome was 16 540 bp in size and contained typical sets of genes (13 protein-coding genes, 22 tRNAs, and 2 rRNAs). The C. atrox A+T-rich region, at 1402 bp, was the longest of all sequenced ant genomes and was composed of an identical tandem repeat consisting of six 100-bp copies and one 96-bp copy. A total of 315 bp of intergenic spacer sequence was spread over 23 regions. An alignment of the spacer sequences in ants was largely feasible among congeneric species, and there was substantial sequence divergence, indicating their potential use as molecular markers for congeneric species. The A/T contents at the first and second codon positions of protein-coding genes (PCGs) were similar for ant species, including C. atrox (73.9% vs. 72.3%, on average). With increased taxon sampling among hymenopteran superfamilies, differences in the divergence rates (i.e., the non-synonymous substitution rates) between the suborders Symphyta and Apocrita were detected, consistent with previous results. The C. atrox mt genome had a unique gene arrangement, trnI-trnM-trnQ, at the A+T-rich region and ND2 junction (underline indicates inverted gene). This may have originated from a tandem duplication of trnM-trnI, resulting in trnM-trnI-trnM-trnI-trnQ, and the subsequent loss of the first trnM and second trnI, resulting in trnI-trnM-trnQ.

  13. 29 CFR 794.117 - Effect of franchises and other arrangements.


    ... 29 Labor 3 2010-07-01 2010-07-01 false Effect of franchises and other arrangements. 794.117... âindependently Owned and Controlled Local Enterpriseâ § 794.117 Effect of franchises and other arrangements. Whether a franchise or other contractual arrangement affects the status of the enterprise as...

  14. 46 CFR 167.20-17 - Bilge pumps, bilge piping and sounding arrangements.


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Bilge pumps, bilge piping and sounding arrangements. 167... Ships § 167.20-17 Bilge pumps, bilge piping and sounding arrangements. The number, capacity, and arrangement of bilge pumps and bilge piping shall be in accordance with the requirements for cargo...

  15. 12 CFR 714.3 - Must you own the leased property in an indirect leasing arrangement?


    ... leasing arrangement? 714.3 Section 714.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS LEASING § 714.3 Must you own the leased property in an indirect leasing arrangement? You do not have to own the leased property in an indirect leasing arrangement if: (a) You...

  16. The Life Course of Children Born to Unmarried Mothers: Childhood Living Arrangements and Young Adult Outcomes.

    Aquilino, William S.


    Explored living arrangements among children born to unmarried mothers and the impact of childhood living arrangements on the young adult's life course. Analyses showed that living arrangement patterns after birth to a single mother influenced the likelihood of high school completion, post secondary education, and other conditions. (RJM)

  17. Designing efficient surveys: spatial arrangement of sample points for detection of invasive species

    Ludek Berec; John M. Kean; Rebecca Epanchin-Niell; Andrew M. Liebhold; Robert G. Haight


    Effective surveillance is critical to managing biological invasions via early detection and eradication. The efficiency of surveillance systems may be affected by the spatial arrangement of sample locations. We investigate how the spatial arrangement of sample points, ranging from random to fixed grid arrangements, affects the probability of detecting a target...

  18. Gender and Ethnic Variation in Arranged Marriages in a Chinese City

    Zang, Xiaowei


    Using a data set (N = 1,600) collected in the city of Urumchi in 2005, this article examines ethnic differences in arranged marriages in urban China. Data analysis shows a rapid decline in parental arrangement for both Uyghur Muslims and Han Chinese in Urumchi. Han Chinese are less likely than Uyghur Muslims to report arranged marriages, with main…

  19. 1 CFR 20.6 - Form, style, arrangement and apportionment of space.


    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form, style, arrangement and apportionment of... Form, style, arrangement and apportionment of space. The form, style, and arrangement of agency... determined by the Director of the Federal Register. The U.S. Government Printing Office Style Manual is...

  20. Evaluation of alternative institutional arrangements in public utilities

    Ermishina Anna, V.


    Full Text Available Since early 2000s a policy of attracting private operators to public utilities, which should help to increase productivity, reduce costs, and as a result, reduce utility prices takes place in Russia. The aim of the study is to identify the relationship between institutional arrangements and pricing for water and wastewater services. Applying statistical and cluster analysis to empirical data on water utilities in 13 largest cities has revealed the differences in the level and dynamics of prices for water and wastewater services in the group of public utilities and public private water utilities. In 2011-2014 the level and growth price rates in the group of public private partnerships were higher than in group of municipal water utilities. Thus, the involvement of private operators has not yet lead to the expected reduction in prices.

  1. New arrangements in force in the field of transport

    Tom Wegelius


    Please take note of the following information concerning new arrangements in force in the field of transport: China: Regulations applying to wooden packaging materials as of 1st January 2006 As scheduled, China introduced standard ISPM No. 15 on 1st January 2006. This was officially confirmed in a letter from the Federal Minister for Consumer Protection, Food and Agriculture. Henceforth, China will apply the same conditions to the importation of wooden packaging materials as various other countries, including the United States, Mexico and Brazil. This means that items shipped to China in wooden packaging will no longer need to be accompanied by a certificate relating to the protection of plant species or other phytosanitary documents (such as heat treatment certificates). However, a guarantee that the wooden packaging complies with standard ISPM No. 15 will be required. Phase II of US regulations concerning wooden packaging material Phase II of regulations concerning the importation of wooden packaging ma...

  2. Neoliberalism and criticisms of earthquake insurance arrangements in New Zealand.

    Hay, I


    Global collapse of the Fordist-Keynesian regime of accumulation and an attendant philosophical shift in New Zealand politics to neoliberalism have prompted criticisms of, and changes to, the Earthquake and War Damage Commission. Earthquake insurance arrangements made 50 years ago in an era of collectivist, welfarist political action are now set in an environment in which emphasis is given to competitive relations and individualism. Six specific criticisms of the Commission are identified, each of which is founded in the rhetoric and ideology of a neoliberal political project which has underpinned radical social and economic changes in New Zealand since the early 1980s. On the basis of those criticisms, and in terms of the Earthquake Commission Act 1993, the Commission has been restructured. The new Commission is withdrawing from its primary position as the nation's non-residential property hazards insurer and is restricting its coverage of residential properties.

  3. Multiple transnational household arrangements in the city of Cochabamba

    Carmen Ledo García


    Full Text Available Evidence shows that over the last 15 years Bolivia and Cochabamba have experienced increased migration flows and that international emigration has become an important strategy for many households. The purpose of this article is to show intra-family solidarity, as well as how households respond to an absent parent in the Cochabamba urban area. The simultaneous interaction of six analytic dimensions is analysed: the socio-economic situation in the country of origin; the characteristics of migrants in the host country; maternal/paternal communication from a distance; the role of remittances; and political participation and role changes within the family remaining in the country of origin. The procedure of generalized canonical correlation analysis (GCCA allows us to demonstrate the multiple transnational maternity/paternity arrangements and the solidarity of the family networks in Cochabamba.

  4. The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly.

    Magidson, Valentin; O'Connell, Christopher B; Lončarek, Jadranka; Paul, Raja; Mogilner, Alex; Khodjakov, Alexey


    Error-free chromosome segregation requires stable attachment of sister kinetochores to the opposite spindle poles (amphitelic attachment). Exactly how amphitelic attachments are achieved during spindle assembly remains elusive. We employed photoactivatable GFP and high-resolution live-cell confocal microscopy to visualize complete 3D movements of individual kinetochores throughout mitosis in nontransformed human cells. Combined with electron microscopy, molecular perturbations, and immunofluorescence analyses, this approach reveals unexpected details of chromosome behavior. Our data demonstrate that unstable lateral interactions between kinetochores and microtubules dominate during early prometaphase. These transient interactions lead to the reproducible arrangement of chromosomes in an equatorial ring on the surface of the nascent spindle. A computational model predicts that this toroidal distribution of chromosomes exposes kinetochores to a high density of microtubules which facilitates subsequent formation of amphitelic attachments. Thus, spindle formation involves a previously overlooked stage of chromosome prepositioning which promotes formation of amphitelic attachments.

  5. Atomic arrangement and charge distribution in YBCO tilt grain boundaries

    Bording, J. K.; Halley, J. W.; Zhu, Y.


    It is well known that the critical current, Jc, in high-Tc superconductors is reduced at grain boundaries. Recent high resolution holography experiments show the [100] tilt grain boundaries in YBa2Cu3O7-x to have an excess negative charge localized at the boundary dislocation core. Upon doping with Ca, this charge is reduced and the critical current increased. To shed light on this behavior at an atomic scale, we carried out Tight Binding (TB) calculations of these boundaries. Our TB scheme is charge self consistent to allow charge transfer typical for ionic materials. We present the arrangement of atoms and charge in YBCO tilt grain boundaries as determined by a combination of TB calculations, recent high resolution Scanning Transmission Electron Microscopy and Electron Energy Loss Spectroscopy measurements.

  6. Dementia prevalence, care arrangement, and access to care in Lebanon

    Phung, Thien Kieu Thi; Chaaya, Monique; Prince, Martin


    INTRODUCTION: In North Africa and the Middle East, studies about dementia prevalence are scarce. A pilot study was conducted in Lebanon to assess dementia prevalence, using the Arabic-validated 10/66 Dementia Research Group (DRG) diagnostic assessment for case ascertainment. The study also examined...... care arrangement and access to care. METHODS: A random sample of 502 persons older than 65 years and their informant were recruited from Beirut and Mount Lebanon governorates through multistage cluster sampling. RESULTS: The crude and age-standardized dementia prevalences were 7.4% and 9.......0%, respectively. People with dementia were mainly cared for by relatives at home. Access to formal care was very limited. DISCUSSION: Dementia prevalence in Lebanon ranks high within the global range of estimates. These first evidence-based data about disease burden and barriers to care serve to raise awareness...

  7. Licensing arrangements and the development of the solar energy industry

    Green, M.


    The process by which technology and information related to technology are transferred within industry is explored. Property rights in technology are part of the broader field of intellectual property. The general contours of legal protection for knowledge are explored. The four basic forms of intellectual property - patents, trade secrets (or know-how), trademarks, and copyrights - are covered in varying degrees of depth, depending on their relative applicability to the development of the solar industry. Once this background has been established, the legal aspects of licensing are examined. A license is a legal arrangement whereby a party (licensor) who controls the right to use an idea, invention, etc. shares the right to use the particular intellectual property with someone else (licensee). The advantages and disadvantages of licensing are described from the point of view of potential licensees and licensors. Barriers to licensing are discussed.

  8. Visualizing Similarity of Appearance by Arrangement of Cards.

    Nakatsuji, Nao; Ihara, Hisayasu; Seno, Takeharu; Ito, Hiroshi


    This study proposes a novel method to extract the configuration of the psychological space by directly measuring subjects' similarity rating without computational work. Although multidimensional scaling (MDS) is well-known as a conventional method for extracting the psychological space, the method requires many pairwise evaluations. The times taken for evaluations increase in proportion to the square of the number of objects in MDS. The proposed method asks subjects to arrange cards on a poster sheet according to the degree of similarity of the objects. To compare the performance of the proposed method with the conventional one, we developed similarity maps of typefaces through the proposed method and through non-metric MDS. We calculated the trace correlation coefficient among all combinations of the configuration for both methods to evaluate the degree of similarity in the obtained configurations. The threshold value of trace correlation coefficient for statistically discriminating similar configuration was decided based on random data. The ratio of the trace correlation coefficient exceeding the threshold value was 62.0% so that the configurations of the typefaces obtained by the proposed method closely resembled those obtained by non-metric MDS. The required duration for the proposed method was approximately one third of the non-metric MDS's duration. In addition, all distances between objects in all the data for both methods were calculated. The frequency for the short distance in the proposed method was lower than that of the non-metric MDS so that a relatively small difference was likely to be emphasized among objects in the configuration by the proposed method. The card arrangement method we here propose, thus serves as a easier and time-saving tool to obtain psychological structures in the fields related to similarity of appearance.

  9. A theory for the arrangement of sensory organs in Drosophila

    Zhu, Huifeng; Gunaratne, Preethi H.; Roman, Gregg W.; Gunaratne, Gemunu H.


    We study the arrangements of recurved bristles on the anterior wing margin of wild-type and mutant Drosophila. The epidermal or neural fate of a proneural cell depends on the concentrations of proteins of the achaete-scute complex. At puparium formation, concentrations of proteins are nearly identical in all cells of the anterior wing and each cell has the potential for neural fate. In wild-type flies, the action of regulatory networks drives the initial state to one where a bristle grows out of every fifth cell. Recent experiments have shown that the frequency of recurved bristles can be made to change by adjusting the mean concentrations of the zinc-finger transcription factor Senseless and the micro-RNA miR-9a. Specifically, mutant flies with reduced levels of miR-9a exhibit ectopic bristles, and those with lower levels of both miR-9a and Senseless show regular organization of recurved bristles, but with a lower periodicity of 4. We argue that these characteristics can be explained assuming an underlying Turing-type bifurcation whereby a periodic pattern spontaneously emerges from a uniform background. However, bristle patterns occur in a discrete array of cells, and are not mediated by diffusion. We argue that intracellular actions of transmembrane proteins such as Delta and Notch can play a role of diffusion in destabilizing the homogeneous state. In contrast to diffusion, intercellular actions can be activating or inhibiting; further, there can be lateral cross-species interactions. We introduce a phenomenological model to study bristle arrangements and make several model-independent predictions that can be tested in experiments. In our theory, miRNA-9a is one of the components of the underlying network and has no special regulatory role. The loss of periodicity in its absence is due to the transfer of the system to a bistable state.

  10. Study on pick arrangement of shearer drum based on load fluctuation

    DU Chang-long; LIU Song-yong; CUI Xin-xia; LI Ti-jian


    According to the coal or rock cutting theory, a mechanical model and computing formula for a pick and the drum load fluctuation model were established in order to obtain relationships between pick arrangements and drum fluctuation loads, drum rotary speeds and haulage speeds. Based on a minimum load fluctuation, an optimal mathematical model was established for drum pick arrangements. The effects of pick arrangements (including punnett square, sequence, aberrance Ⅰ and Ⅱ) on the drum load fluctuation coefficient are discussed. The relationships between the pick arrangements of the drum with different start vanes and the cutting load fluctuation coefficient, the drum rotary speed and haulage speed were also studied. The results indicate that the punnett square arrangement has a smaller cutting load fluctuation coefficient than other forms of arrangement and the drum with the 4-start vanes has the smallest coefficient. The drum rotary speed and haulage speed are affected not only by pick arrangements, but also by the number of vanes.

  11. Necessity of electromagnetic emission network arrangement in Georgia

    Turazashvili, Ioseb; Kachakhidze, Nino; Machavariani, Kakhaber; Kachakhidze, Manana; Gogoberidze, Vitali; Khazaradze, Giorgi


    The field of the tectonic stress has the hierarchical structure. The most characteristic features connected with the regional tectonic elements are determined by the geologic - tectonic data. It is established that in the young folded areas like the Caucasus the field of tectonic stress is characterized by the sharp anisotropy with the predominance of the compression perpendicular to the trend of folding. Spatial location of the main positive and negative geotectonic morphostructures of the Caucasus shows the existence of the wavy tectonic movements in the region. They are caused by the horizontal compression, provoked evidently by advancement of the Arabian lithosphere plate to the North and its re-approach with the Euro-Asian plate. All these cause considerable deformation of the lithosphere of the Caucasian region and its breaking up in separate blocks. This, in its turn, causes the concentration of stress along the boundaries of the blocks and rising of earthquakes focuses there. According to the instrumental data starting from 1899 at about 40 large earthquakes were fixed in the Caucasus. The rate of risks associated with these hazards increases every year in Georgia due to the appearance of new complicated technological construction: oil and gas pipelines large dams and hydropower plants and others. Modern ground-based and satellite methods of viewing enables to reveal those multiple anomalous geophysical phenomena which become evident in the period preceding earthquake and are directly connected with the process of its preparation. Lately special attention is attributed to the electromagnetic emission fixed during large earthquake and has already been successfully detected in Japan, America and Europe. Unfortunately there is no electromagnetic emission detection network in Georgia yet. The presented abstract concerns arrange of EM emission net and begin implementation of this vital task by arrangement of the one relevant station on the fault near Tbilisi

  12. Arrangement at the nanoscale: Effect on magnetic particle hyperthermia

    Myrovali, E.; Maniotis, N.; Makridis, A.; Terzopoulou, A.; Ntomprougkidis, V.; Simeonidis, K.; Sakellari, D.; Kalogirou, O.; Samaras, T.; Salikhov, R.; Spasova, M.; Farle, M.; Wiedwald, U.; Angelakeris, M.


    In this work, we present the arrangement of Fe3O4 magnetic nanoparticles into 3D linear chains and its effect on magnetic particle hyperthermia efficiency. The alignment has been performed under a 40 mT magnetic field in an agarose gel matrix. Two different sizes of magnetite nanoparticles, 10 and 40 nm, have been examined, exhibiting room temperature superparamagnetic and ferromagnetic behavior, in terms of DC magnetic field, respectively. The chain formation is experimentally visualized by scanning electron microscopy images. A molecular Dynamics anisotropic diffusion model that outlines the role of intrinsic particle properties and inter-particle distances on dipolar interactions has been used to simulate the chain formation process. The anisotropic character of the aligned samples is also reflected to ferromagnetic resonance and static magnetometry measurements. Compared to the non-aligned samples, magnetically aligned ones present enhanced heating efficiency increasing specific loss power value by a factor of two. Dipolar interactions are responsible for the chain formation of controllable density and thickness inducing shape anisotropy, which in turn enhances magnetic particle hyperthermia efficiency.

  13. Tailoring chiro-optical effects by helical nanowire arrangement.

    Esposito, Marco; Tasco, Vittorianna; Todisco, Francesco; Benedetti, Alessio; Tarantini, Iolena; Cuscunà, Massimo; Dominici, Lorenzo; De Giorgi, Milena; Passaseo, Adriana


    In this work, we experimentally investigate the chiro-optical properties of 3D metallic helical systems at optical frequencies. Both single and triple-nanowire geometries have been studied. In particular, we found that in single-helical nanostructures, the enhancement of chiro-optical effects achievable by geometrical design is limited, especially with respect to the operation wavelength and the circular polarization conversion purity. Conversely, in the triple-helical nanowire configuration, the dominant interaction is the coupling among the intertwined coaxial helices which is driven by a symmetric spatial arrangement. Consequently, a general improvement in the g-factor, extinction ratio and signal-to-noise-ratio is achieved in a broad spectral range. Moreover, while in single-helical nanowires a mixed linear and circular birefringence results in an optical activity strongly dependent on the sample orientation and wavelength, in the triple-helical nanowire configuration, the obtained purely circular birefringence leads to a large optical activity up to 8°, independent of the sample angle, and extending in a broad band of 500 nm in the visible range. These results demonstrate a strong correlation between the configurational internal interactions and the chiral feature designation, which can be effectively exploited for nanoscale chiral device engineering.

  14. Influence of continuous mining arrangements on respirable dust exposures

    Beck, T. W.; Organiscak, J. A.; Pollock, D. E.; Potts, J. D.; Reed, W. R.


    In underground continuous mining operations, ventilation, water sprays and machine-mounted flooded-bed scrubbers are the primary means of controlling respirable dust exposures at the working face. Changes in mining arrangements — such as face ventilation configuration, orientation of crosscuts mined in relation to the section ventilation and equipment operator positioning — can have impacts on the ability of dust controls to reduce occupational respirable dust exposures. This study reports and analyzes dust concentrations measured by the Pittsburgh Mining Research Division for remote-controlled continuous mining machine operators as well as haulage operators at 10 U.S. underground mines. The results of these respirable dust surveys show that continuous miner exposures varied little with depth of cut but are significantly higher with exhaust ventilation. Haulage operators experienced elevated concentrations with blowing face ventilation. Elevated dust concentrations were observed for both continuous miner operators and haulage operators when working in crosscuts driven into or counter to the section airflow. Individual cuts are highlighted to demonstrate instances of minimal and excessive dust exposures attributable to particular mining configurations. These findings form the basis for recommendations for lowering face worker respirable dust exposures. PMID:28529441

  15. Toward automated formation of microsphere arrangements using multiplexed optical tweezers

    Rajasekaran, Keshav; Bollavaram, Manasa; Banerjee, Ashis G.


    Optical tweezers offer certain advantages such as multiplexing using a programmable spatial light modulator, flexibility in the choice of the manipulated object and the manipulation medium, precise control, easy object release, and minimal object damage. However, automated manipulation of multiple objects in parallel, which is essential for efficient and reliable formation of micro-scale assembly structures, poses a difficult challenge. There are two primary research issues in addressing this challenge. First, the presence of stochastic Langevin force giving rise to Brownian motion requires motion control for all the manipulated objects at fast rates of several Hz. Second, the object dynamics is non-linear and even difficult to represent analytically due to the interaction of multiple optical traps that are manipulating neighboring objects. As a result, automated controllers have not been realized for tens of objects, particularly with three dimensional motions with guaranteed collision avoidances. In this paper, we model the effect of interacting optical traps on microspheres with significant Brownian motions in stationary fluid media, and develop simplified state-space representations. These representations are used to design a model predictive controller to coordinate the motions of several spheres in real time. Preliminary experiments demonstrate the utility of the controller in automatically forming desired arrangements of varying configurations starting with randomly dispersed microspheres.

  16. Corn plant arrangement and its effect on silage quality

    Fernando Reimann Skonieski


    Full Text Available This experiment was carried out to evaluate the effects of the row spacing between corn plants on silage quality. Different spacing between corn rows (40, 60, and 80 cm was used, but the population of plants was maintained around 65,000/ha in all treatments. Analysis of variance was carried out and means were compared by Tukey's test at 5% of probability. A reduction in row spacing provided better spatial distribution of plants, but did not alter morphological composition or dry matter production. The corn with most equidistant spatial distribution (lowest row spacing showed an increase in lignin concentration, neutral detergent fiber, and total carbohydrates, and showed a decrease in total digestible nutrients when compared with 80 cm row spacing. However, the organic digestibility matter was not affected by the treatments. The content and quality of protein were higher for 80 cm row spacing compared with the other levels; also, protein content was reduced as the spacing between rows became smaller. The only mineral affected was calcium, which had the lowest value at higher levels of spacing. Although differences were detected for many variables, the most appropriate spacing between rows should also take into account economic and practical aspects when choosing the best plant arrangement.

  17. Earth Observation Data Interoperability Arrangement with Ontology Registry

    Nagai, M.; Ono, M.; Shibasaki, R.


    Standardization organizations are working for syntactic and schematic level of interoperability. At the same time, semantic interoperability must be considered as a heterogeneous condition and also very diversified with a large-volume data. The ontology registry has been developed and ontological information such as technical vocabularies for earth observation has been collected for data interoperability arrangement. This is a very challenging method for earth observation data interoperability because collaboration or cooperation with scientists of different disciplines is essential for common understanding. Multiple semantic MediaWikis are applied to register and update technical vocabularies as a part of the ontology registry, which promises to be a useful tool for users. In order to invite contributions from the user community, it is necessary to provide sophisticated and easy-to-use tools and systems, such as table-like editor, reverse dictionary, and graph representation for sustainable development and usage of ontological information. Registered ontologies supply the reference information required for earth observation data retrieval. We proposed data/metadata search with ontology such as technical vocabularies and visualization of relations among dataset to very large scale and various earth observation data.

  18. Optimal design of the satellite constellation arrangement reconfiguration process

    Fakoor, Mahdi; Bakhtiari, Majid; Soleymani, Mahshid


    In this article, a novel approach is introduced for the satellite constellation reconfiguration based on Lambert's theorem. Some critical problems are raised in reconfiguration phase, such as overall fuel cost minimization, collision avoidance between the satellites on the final orbital pattern, and necessary maneuvers for the satellites in order to be deployed in the desired position on the target constellation. To implement the reconfiguration phase of the satellite constellation arrangement at minimal cost, the hybrid Invasive Weed Optimization/Particle Swarm Optimization (IWO/PSO) algorithm is used to design sub-optimal transfer orbits for the satellites existing in the constellation. Also, the dynamic model of the problem will be modeled in such a way that, optimal assignment of the satellites to the initial and target orbits and optimal orbital transfer are combined in one step. Finally, we claim that our presented idea i.e. coupled non-simultaneous flight of satellites from the initial orbital pattern will lead to minimal cost. The obtained results show that by employing the presented method, the cost of reconfiguration process is reduced obviously.

  19. Cooperating internationally. US/Japan Civil Industrial Technologies (CIT) Arrangement



    The Civil Industrial Technologies (CIT) Arrangement was signed in July 1994 between governments of the US and Japan. Areas of research range from scientific and technical databases and bioprocessing to precompetitive processing of functionally-gradient materials and ceramics. Papers presented in this symposium include studies on thin polymer films generated by vapor deposition polymerization, development of manufacturing technique of fusing 3D C/C composite materials, measurement and analysis for high performance computing systems, low-cost fabrication of ceramic components, bioprocessing, data exchange for mass spectral databases, development of high performance aluminum nitride ceramics, precompetitive processing of functionally-gradient materials, purity determination of organic reference materials, definitive methods traceable to SI unit, development of biocompatible artificial hard tissue materials, development of photoassisted catalysis technologies, surface analysis for catalysts by electron spectroscopy, development of ultra-solid lubricant with cluster diamond, precise determination of impurities in high-purity rare-earth metals, and highly accurate acceleration measurement system. 22 refs., 86 figs., 3 tabs.

  20. Item difficulty scaling for WAIS-III picture arrangement.

    Costello, Raymond M; Connolly, Sean G


    Only one study regarding the sequencing of items of the WAIS-III Picture Arrangement subtest was located in a search of published literature. That study of 50 alcohol abusers failed to demonstrate that the items are sequenced in the perfect order of difficulty as suggested by the test publisher. The current study was accomplished to replicate or refute the prior study and to extend findings into related matters. Two laboratories provided four archival samples of 100 cases. Only five items appear properly placed, with one (OPENS) especially misplaced. A new sequence is recommended so that clinicians can administer the test more efficiently and examine errors from a process approach to evaluation. Difficult items were not passed as often as expected by Hispanic respondents. This finding was considered an artifact related to archival convenience sampling and may not be representative as a general finding regarding Hispanic performance until experimental sampling techniques or proper statistical controls can be applied. Statistically controlling for IQ, through analysis of covariance, eliminated ethnicity effects on total score for the PA subtest.

  1. Eating together and eating alone: meal arrangements in British households.

    Yates, Luke; Warde, Alan


    Sociology traditionally accounts for eating in terms of the social organization of meals, their provision and consumption. A recurrent public concern is that the meal is being subverted. This paper examines meal arrangements in British households in 2012, drawing on an online survey in the format of a food diary administered to 2784 members of a supermarket consumer panel. It charts the organization of contemporary eating occasions, paying attention to socio-demographic variation in practice. Especially, it explores companionless meals, putting them in contexts of food provisioning and temporal rhythms. Findings show that eating alone is associated with simpler, quicker meals, and that it takes place most commonly in the morning and midday. Those living alone eat alone more often, but at similar meal times, and they take longer over their lone meals. Comparison with a similar study in 1955-6 suggests some fragmentation or relaxation in collective schedules. The implications are not straightforward, and the causes probably lie more in institutional shifts than personal preferences. Declining levels of commensality are, however, associated with a reduction in household size and, especially in households with children, difficulties of coordinating family members' schedules.

  2. The boundaries of public action: arranged and forced marriages

    Daniela Danna


    Full Text Available In this article I deal with the political and cultural dilemma of the distinction between arranged and forced or imposed marriages. After a review of the literature, interviews collected in 2009 in the Italian region of Emilia-Romagna are used to illustrate the views of the participants to the research. With the help of the theoretical tool of cultural materialism, I argue that the question can be approached from two different points of view: on the one hand, the distinction is clear as it is based on the recognition (even a late one of an imposition by physical or psychological violence on the part of the subject; on the other hand sociological analysis of the process of construction and of expression of consent reveals a vast gray area that is object of debate in the scientific literature as well as in everyday life. Only the first definition of forced marriage, the subjective one, can justify the start of a concrete intervention by the public authorities - but this cannot stop the debate on the actual value of the consent given in many cases of marriages.

  3. [Arranged marriages of underage girls and the resulting psychic consequences].

    Ebigbo, P O


    This study is based on 20 cases of disturbed female clients whose marriages were arranged at an under age ranging from 9-13 years. When the men have paid the dowry and fulfilled the marriage customs they are entitled to have sexual intercourse with their wives. Some have this sexual intercourse before or shortly after menstruation and some even have seen their husbands only once or twice before their hands are given in marriage. This early sexual experience, mostly against the will of the underage girls, can precipitate positive or negative reactions. In the positive reaction cases an imprinting fixation on the man takes place. Should the man die or reject the young woman, a disorientation takes place resulting mostly in an inability to have sexual relationship with another man. Should the reaction be negative the woman will do all she can to prevent sexual relationship with the husband through all sorts of symptoms like frequent pregnancies, crawling sensation, secret love affairs with remorse of concience, internal heat, constant head-ache etc. 2 cases are selected from the 20 cases as illustration.

  4. Marital processes, arranged marriage, and contraception to limit fertility.

    Ghimire, Dirgha J; Axinn, William G


    An international transition away from familially arranged marriages toward participation in spouse choice has endured for decades and continues to spread through rural Asia today. Although we know that this transformation has important consequences for childbearing early in marriage, we know much less about longer-term consequences of this marital revolution. Drawing on theories of family and fertility change and a rural Asian panel study designed to measure changes in both marital and childbearing behaviors, this study seeks to investigate these long-term consequences. Controlling for social changes that shape both marital practices and childbearing behaviors, and explicitly considering multiple dimensions of marital processes, we find evidence consistent with an independent, long-standing association of participation in spouse choice with higher rates of contraception to terminate childbearing. These results add a new dimension to the evidence linking revolutions in marital behavior to long-term declines in fertility and suggest that new research should consider a broader range of long-term consequences of changing marital processes.

  5. New perspectives about molecular arrangement of primary and permanent dentin

    Sanches Borges, Ana Flavia [Department of Dental Materials at Piracicaba Dental School, State University of Campinas, Piracicaba, SP (Brazil); Andrade Bitar, Renata [Biomedical Engineering, Valley of Paraiba University (UNIVAP) (Brazil); Kantovitz, Kamila Rosamilia [Department of Pediatric Dentistry at Piracicaba Dental School, State University of Campinas, Piracicaba, SP (Brazil); Bortollazo Correr, Americo [Department of Dental Materials at Piracicaba Dental School, State University of Campinas, Piracicaba, SP (Brazil); Martin, Airton Abrahao [Biomedical Engineering Post Graduation, Valley of Paraiba University (UNIVAP) (Brazil); Puppin-Rontani, Regina Maria [Department of Pediatric Dentistry at Piracicaba Dental School, State University of Campinas, Piracicaba, SP (Brazil)], E-mail:


    The dentin quality of primary and permanent teeth was inspected by Fourier transformed Raman spectroscopy (FT-Raman); scanning electron microscopy/energy-dispersive spectroscopy (SEM/EDS) and hardness test. Middle dentin of crowns were reached by carbide bur abrading providing a uniform smear layer. Phosphoric acid was applied in order to simulate the etching of total etching adhesive systems. The groups were (n = 10): G1 (primary dentin smear layer); G2 (35% phosphoric acid etched primary dentin); G3 (permanent dentin smear layer); G4 (35% phosphoric acid etched permanent dentin). FT-Raman results were subjected to cluster analysis. SEM/EDS were made in order to add the data obtained by FT-Raman. The hardness data were subjected to ANOVA and Tukey test. FT-Raman showed differences among groups, either to organic or inorganic content. For the organic content, primary and permanent dentin became similar after the etching; conversely, the inorganic content showed differences for the two substrates. Hardness test showed no significant differences between primary and permanent dentin, before or after etching, but the etching decreased these values. The mineral content arrangement of primary dentin is different from permanent dentin, independently of the etching. The substrate type did no influence the hardness, but the etching decreased it.

  6. Dynamics of circular arrangements of vorticity in two dimensions

    Swaminathan, Rohith V; Perlekar, Prasad; Govindarajan, Rama


    The merger of two like-signed vortices is a well-studied problem, but in a turbulent flow, we may often have more than two like-signed vortices interacting. We study the merger of three or more identical co-rotating vortices initially arranged on the vertices of a regular polygon. At low to moderate Reynolds numbers, we find an additional stage in the merger process, absent in the merger of two vortices, where an annular vortical structure is formed and is long-lived. Vortex merger is slowed down significantly due to this. Such annular vortices are known at far higher Reynolds numbers in studies of tropical cyclones, which have been noticed to break down into individual vortices. In the pre-annular stage, vortical structures in a viscous flow tilt and realign in a manner similar to the inviscid case, but the pronounced filaments visible in the latter are practically absent in the former. Five or fewer vortices initially elongate radially, and then reorient their long axis closer to the azimuthal direction so ...

  7. Strategy to Arrange Gender Responsive Budget in ex Besuki Residency

    Sulistio Adiwinarto


    Full Text Available This study aims to determine the participation of women in development planning meeting, knowing the form of gender responsive policies, identifying the cause of the gender responsive policy problem, and strategy formulation of the budget in ex Besuki Residency such as Jember, Bondowoso, Situbondo, and Banyuwangi which still not responsive to the needs of women. In the first year, this study intends to identify the process of formulation, implementation, and evaluation of the local budget in Ex Besuki residency conducted by the respective local governments. Based on the research in the first year, researchers will formulate development strategies in the formulation of gender-responsive policies. The method of research is quantitative descriptive study, study documentation, primary and secondary data analysis, interviews and focus group discussions. In the second year of the study are expected to form a strategy and policy formulation concept of gender responsive budgeting through a combination previously existing concepts, adapted to the results of the first year of study at the study site. How To Cite: Adiwinarto, S., & Nusanto, B. (2015. Strategy to Arrange Gender Responsive Budget in ex Besuki Residency. Rechtsidee, 2(1, 65-78. doi:

  8. Overlapping arrangement of the recF and dnaN operons of Escherichia coli; positive and negative control sequences.

    Armengod, M E; Lambíes, E


    The recF gene of Escherichia coli controls one of the recombination pathways and UV sensitivity, but its precise function and expression pattern are still largely unknown. We have characterized the promoter region of the recF gene by mapping for E. coli RNA polymerase binding sites, in vitro transcription experiments, cloning, and S1 mapping of in vivo mRNAs. It contains three overlapping promoters, two initiating transcription towards recF and one in the opposite direction. The recF promoter region is located about 600 bp upstream from the start codon of the recF structural gene and resides entirely within the translated region of the preceding gene, dnaN, which encodes for the beta subunit of DNA polymerase III. This unusual arrangement might provide discoordinate regulation of the recF and dnaN genes, thus controlling the level of DNA polymerase III holoenzyme. Expression of recF is also negatively controlled by sequences located upstream as well as inside the recF coding frame. Such negative regulation may serve to prevent toxic effects due to accumulation of an excessive number of copies of the recF gene product.

  9. Linking better shiftwork arrangements with safety and health management systems

    Kazutaka Kogi


    Full Text Available OBJECTIVE: Various support measures useful for promoting joint change approaches to the improvement of both shiftworking arrangements and safety and health management systems were reviewed. A particular focus was placed on enterprise-level risk reduction measures linking working hours and management systems. METHODS: Voluntary industry-based guidelines on night and shift work for department stores and the chemical, automobile and electrical equipment industries were examined. Survey results that had led to the compilation of practicable measures to be included in these guidelines were also examined. The common support measures were then compared with ergonomic checkpoints for plant maintenance work involving irregular nightshifts. On the basis of this analysis, a new night and shift work checklist was designed. RESULTS: Both the guidelines and the plant maintenance work checkpoints were found to commonly cover multiple issues including work schedules and various job-related risks. This close link between shiftwork arrangements and risk management was important as shiftworkers in these industries considered teamwork and welfare services to be essential for managing risks associated with night and shift work. Four areas found suitable for participatory improvement by managers and workers were work schedules, ergonomic work tasks, work environment and training. The checklist designed to facilitate participatory change processes covered all these areas. CONCLUSIONS: The checklist developed to describe feasible workplace actions was suitable for integration with comprehensive safety and health management systems and offered valuable opportunities for improving working time arrangements and job content together.OBJETIVOS: Foram revisados diversas medidas de apoio úteis para incentivar abordagens conjuntas para a melhoria na organização do trabalho por turnos e os processos de gestão de saúde e segurança. As medidas para redução de risco em n

  10. They call it competence, and it is for sale : Decisions and effects of master vendor arrangements

    Land, Mia-Berentje; Busatlija, Emina


    Background Temporary work agencies have been around for several decades. An emerging outgrowth from these has been expanding in the industry, known as master vendor arrangements. Furthermore, much research has been devoted to the usage of temporary working agencies but less attention has been devoted to the master vendor arrangements and the consequences from using such an arrangement. Purpose The purpose of this study is to explore the strategic decision of implementing a master vendor arran...

  11. Optimization of lamp arrangement in a closed-conduit UV reactor based on a genetic algorithm.

    Sultan, Tipu; Ahmad, Zeshan; Cho, Jinsoo


    The choice for the arrangement of the UV lamps in a closed-conduit ultraviolet (CCUV) reactor significantly affects the performance. However, a systematic methodology for the optimal lamp arrangement within the chamber of the CCUV reactor is not well established in the literature. In this research work, we propose a viable systematic methodology for the lamp arrangement based on a genetic algorithm (GA). In addition, we analyze the impacts of the diameter, angle, and symmetry of the lamp arrangement on the reduction equivalent dose (RED). The results are compared based on the simulated RED values and evaluated using the computational fluid dynamics simulations software ANSYS FLUENT. The fluence rate was calculated using commercial software UVCalc3D, and the GA-based lamp arrangement optimization was achieved using MATLAB. The simulation results provide detailed information about the GA-based methodology for the lamp arrangement, the pathogen transport, and the simulated RED values. A significant increase in the RED values was achieved by using the GA-based lamp arrangement methodology. This increase in RED value was highest for the asymmetric lamp arrangement within the chamber of the CCUV reactor. These results demonstrate that the proposed GA-based methodology for symmetric and asymmetric lamp arrangement provides a viable technical solution to the design and optimization of the CCUV reactor.

  12. IRS Notice 2002-8 clarifies split-dollar life insurance arrangements.

    Ledbetter, Thomas L


    Healthcare organizations that sponsor split-dollar life insurance arrangements for employees need to understand the tax treatment of such arrangements. IRS Notice 2002-8 clarifies this issue. The notice announces the IRS's intention to publish final regulations regarding the taxation of split-dollar life insurance, outlines the expected provisions to be included in the regulations, provides guidance on the value of economic benefit provided under such arrangements, and issues rules for the taxation of arrangements entered into before the publication of final rules.

  13. Dynamics of circular arrangements of vorticity in two dimensions

    Swaminathan, Rohith V.; Ravichandran, S.; Perlekar, Prasad; Govindarajan, Rama


    The merger of two like-signed vortices is a well-studied problem, but in a turbulent flow, we may often have more than two like-signed vortices interacting. We study the merger of three or more identical corotating vortices initially arranged on the vertices of a regular polygon. At low to moderate Reynolds numbers, we find an additional stage in the merger process, absent in the merger of two vortices, where an annular vortical structure is formed and is long lived. Vortex merger is slowed down significantly due to this. Such annular vortices are known at far higher Reynolds numbers in studies of tropical cyclones, which have been noticed to a break down into individual vortices. In the preannular stage, vortical structures in a viscous flow are found here to tilt and realign in a manner similar to the inviscid case, but the pronounced filaments visible in the latter are practically absent in the former. Five or fewer vortices initially elongate radially, and then reorient their long axis closer to the azimuthal direction so as to form an annulus. With six or more vortices, the initial alignment is already azimuthal. Interestingly at higher Reynolds numbers, the merger of an odd number of vortices is found to proceed very differently from that of an even number. The former process is rapid and chaotic whereas the latter proceeds more slowly via pairing events. The annular vortex takes the form of a generalized Lamb-Oseen vortex (GLO), and diffuses inward until it forms a standard Lamb-Oseen vortex. For lower Reynolds number, the numerical (fully nonlinear) evolution of the GLO vortex follows exactly the analytical evolution until merger. At higher Reynolds numbers, the annulus goes through instabilities whose nonlinear stages show a pronounced difference between even and odd mode disturbances. Here again, the odd mode causes an early collapse of the annulus via decaying turbulence into a single central vortex, whereas the even mode disturbance causes a more

  14. Novel structural arrangement of nematode cystathionine β-synthases: characterization of Caenorhabditis elegans CBS-1.

    Vozdek, Roman; Hnízda, Aleš; Krijt, Jakub; Kostrouchová, Marta; Kožich, Viktor


    CBSs (cystathionine β-synthases) are eukaryotic PLP (pyridoxal 5 *-phosphate)-dependent proteins that maintain cellular homocysteine homoeostasis and produce cystathionine and hydrogen sulfide. In the present study, we describe a novel structural arrangement of the CBS enzyme encoded by the cbs-1 gene of the nematode Caenorhabditis elegans. The CBS-1 protein contains a unique tandem repeat of two evolutionarily conserved catalytic regions in a single polypeptide chain. These repeats include a catalytically active C-terminal module containing a PLP-binding site and a less conserved N-terminal module that is unable to bind the PLP cofactor and cannot catalyse CBS reactions, as demonstrated by analysis of truncated variants and active-site mutant proteins. In contrast with other metazoan enzymes, CBS-1 lacks the haem and regulatory Bateman domain essential for activation by AdoMet (S-adenosylmethionine) and only forms monomers. We determined the tissue and subcellular distribution of CBS-1 and showed that cbs-1 knockdown by RNA interference leads to delayed development and to an approximately 10-fold elevation of homocysteine concentrations in nematode extracts. The present study provides the first insight into the metabolism of sulfur amino acids and hydrogen sulfide in C. elegans and shows that nematode CBSs possess a structural feature that is unique among CBS proteins.

  15. How a spatial arrangement of secondary structure elements is dispersed in the universe of protein folds.

    Shintaro Minami

    Full Text Available It has been known that topologically different proteins of the same class sometimes share the same spatial arrangement of secondary structure elements (SSEs. However, the frequency by which topologically different structures share the same spatial arrangement of SSEs is unclear. It is important to estimate this frequency because it provides both a deeper understanding of the geometry of protein folds and a valuable suggestion for predicting protein structures with novel folds. Here we clarified the frequency with which protein folds share the same SSE packing arrangement with other folds, the types of spatial arrangement of SSEs that are frequently observed across different folds, and the diversity of protein folds that share the same spatial arrangement of SSEs with a given fold, using a protein structure alignment program MICAN, which we have been developing. By performing comprehensive structural comparison of SCOP fold representatives, we found that approximately 80% of protein folds share the same spatial arrangement of SSEs with other folds. We also observed that many protein pairs that share the same spatial arrangement of SSEs belong to the different classes, often with an opposing N- to C-terminal direction of the polypeptide chain. The most frequently observed spatial arrangement of SSEs was the 2-layer α/β packing arrangement and it was dispersed among as many as 27% of SCOP fold representatives. These results suggest that the same spatial arrangements of SSEs are adopted by a wide variety of different folds and that the spatial arrangement of SSEs is highly robust against the N- to C-terminal direction of the polypeptide chain.

  16. Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus

    Carlos Wong-Baeza


    Full Text Available Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens. Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies against nonbilayer phospholipid arrangements. As the effect of these liposomes on the innate immune response is unknown and innate immune system activation is necessary for efficient antibody formation, we evaluated the effect of these liposomes on Toll-like receptor (TLR signaling, cytokine production, proinflammatory gene expression, and T, NKT, dendritic, and B cells. Liposomes induce TLR-4- and, to a lesser extent, TLR-2/TLR-6-dependent signaling in TLR-expressing human embryonic kidney (HEK cells and bone marrow-derived macrophages. Mice with the lupus-like disease had increased serum concentrations of proinflammatory cytokines, C3a and C5a; they also had more TLR-4-expressing splenocytes, a higher expression of genes associated with TRIF-dependent TLR-4-signaling and complement activation, and a lower expression of apoptosis-related genes, compared to healthy mice. The percentage of NKT and the percentage and activation of dendritic and B2 cells were also increased. Thus, TLR-4 and TLR-2/TLR-6 activation by nonbilayer phospholipid arrangements triggers an inflammatory response that could contribute to autoantibody production and the generation of a lupus-like disease in mice.

  17. Considerations for Classroom Seating Arrangements and the Role of Teacher Characteristics and Beliefs

    Gremmen, Mariola C.; van den Berg, Yvonne H. M.; Segers, Eliane; Cillessen, Antonius H. N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4-6 of elementary school were assessed. In Phase 1, teachers…

  18. 76 FR 386 - Proposed Information Collection Request for the ETA 586, Interstate Arrangement for Combining...


    ... Information Collection Request for the ETA 586, Interstate Arrangement for Combining Employment and Wages... Employment and Wages, Form ETA 586. A copy of the proposed information collection request (ICR) can be... compensation including benefits paid under the CWC arrangement. The ETA 586 report provides the ETA/Office...

  19. Institutional arrangements in the emerging biodiesel industry: Case studies from Minas Gerais—Brazil

    Watanabe, K.; Bijman, J.; Slingerland, M.A.


    Connecting (small) family farmers to the emerging biodiesel industry requires careful design of the institutional arrangements between the producers of oil crops and the processing companies. According to institutional economics theory, the design of effective and efficient arrangements depends on p

  20. Considerations for classroom seating arrangements and the role of teacher characteristics and beliefs

    Gremmen, M.C.; Berg, Y.H.M. van den; Segers, P.C.J.; Cillessen, A.H.N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4-6 of eleme

  1. 26 CFR 1.61-22 - Taxation of split-dollar life insurance arrangements.


    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Taxation of split-dollar life insurance..., and Taxable Income § 1.61-22 Taxation of split-dollar life insurance arrangements. (a) Scope—(1) In general. This section provides rules for the taxation of a split-dollar life insurance arrangement for...

  2. Does a House Divided Stand? Kinship and the Continuity of Shared Living Arrangements

    Glick, Jennifer E.; Van Hook, Jennifer


    Shared living arrangements can provide housing, economies of scale, and other instrumental support and may become an important resource in times of economic constraint. But the extent to which such living arrangements experience continuity or rapid change in composition is unclear. Previous research on extended-family households tended to focus on…

  3. Adolescent Summer Care Arrangements and Risk for Obesity the Following School Year

    Mahoney, Joseph L.


    This longitudinal study identified common summer care arrangements for adolescents and examined whether those arrangements predicted risk for obesity (Body Mass Index (BMI) [greater than or equal to] 85th percentile for age and gender) the following school year. Participants were a nationally representative sample of 1766 adolescents ages 10-18…

  4. First year effects of induction arrangements on beginning teachers' psychological processes

    Helms-Lorenz, Michelle; Slof, Bert; van de Grift, Wim


    This study examined the (1) effects of a supportive program (i.e., induction arrangement) on beginning teachers' (BTs') psychological processes after a period of 1 year and (2) psychological paths of influence of the arrangement. Participants (56 Dutch secondary schools with 143 BTs) were randomly a

  5. A Set of Indicators to Compare Local Governance Arrangements on Homelessness

    Boesveldt, N.F.|info:eu-repo/dai/nl/162503199


    This article describes a method of comparing new governance arrangements on homelessness by studying three key features: policy, structure and management style. This is done by using a set of indicators that has been developed to measure variations in such arrangements. These indicators are based on

  6. Chromophores arranged as "magnetic meta atoms": building blocks for molecular metamaterials.

    Langhals, Heinz; Hofer, Alexander


    Benzoperylenetriscarboximides were parallel arranged by stiff spacers where exciton interactions could be controlled by their distance. The most bathochromic electronic transition of the chromophores essentially exhibits only an electric component where an orthogonal magnetic component was established by the distance-controlled interaction of chromophores. Such arrangements were discussed as building blocks for molecular metamaterials.

  7. Adolescent Summer Care Arrangements and Risk for Obesity the Following School Year

    Mahoney, Joseph L.


    This longitudinal study identified common summer care arrangements for adolescents and examined whether those arrangements predicted risk for obesity (Body Mass Index (BMI) [greater than or equal to] 85th percentile for age and gender) the following school year. Participants were a nationally representative sample of 1766 adolescents ages 10-18…

  8. The First Flower Arrangement Art Exchange among China,Japan and Korea

    Yu; Xlaodong


    The First Flower Arrangement Art Exchange was held successfully at the CPAFFC auditorium on July 2nd,2015.CPAFFC President Li Xiaolin,speaking at the opening ceremony,said flower arrangement was an art of beauty originating from people’s love

  9. Considerations for classroom seating arrangements and the role of teacher characteristics and beliefs

    Gremmen, Mariola; van den Berg, Y.H.M.; Segers, E.; Cillessen, A.H.N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4–6 of eleme

  10. 46 CFR 76.25-10 - Size and arrangement of sprinkler heads and pipe sizes.


    ... 46 Shipping 3 2010-10-01 2010-10-01 false Size and arrangement of sprinkler heads and pipe sizes... sprinkler heads and pipe sizes. (a) General. (1) The system shall be so designed and arranged that the... projection of the deck is more than 7 feet from a sprinkler head. (b) Pipe sizes. (1) The sizes of branch...

  11. 14 CFR 119.53 - Wet leasing of aircraft and other arrangements for transportation by air.


    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Wet leasing of aircraft and other arrangements for transportation by air. 119.53 Section 119.53 Aeronautics and Space FEDERAL AVIATION... Chapter § 119.53 Wet leasing of aircraft and other arrangements for transportation by air. (a)...

  12. 47 CFR 1.9040 - Contractual requirements applicable to spectrum leasing arrangements.


    ... leasing arrangements. 1.9040 Section 1.9040 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Spectrum Leasing General Policies and Procedures § 1.9040 Contractual requirements applicable to spectrum leasing arrangements. (a) Agreements between licensees and spectrum lessees...

  13. 47 CFR 27.1214 - EBS spectrum leasing arrangements and grandfathered leases.


    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false EBS spectrum leasing arrangements and... Educational Broadband Service § 27.1214 EBS spectrum leasing arrangements and grandfathered leases. (a) A licensee in the EBS that is solely utilizing analog transmissions may enter into a spectrum...

  14. 12 CFR 714.2 - What are the permissible leasing arrangements?


    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What are the permissible leasing arrangements... CREDIT UNIONS LEASING § 714.2 What are the permissible leasing arrangements? (a) You may engage in direct leasing. In direct leasing, you purchase personal property from a vendor, becoming the owner of...

  15. 29 CFR 2590.703 - Guaranteed renewability in multiemployer plans and multiple employer welfare arrangements...


    ... 29 Labor 9 2010-07-01 2010-07-01 false Guaranteed renewability in multiemployer plans and multiple employer welfare arrangements. 2590.703 Section 2590.703 Labor Regulations Relating to Labor (Continued... Guaranteed renewability in multiemployer plans and multiple employer welfare arrangements....

  16. Access to flexible work arrangements, working-time fit and job satisfaction

    Possenriede, D.S.|info:eu-repo/dai/nl/314570365; Plantenga, J.|info:eu-repo/dai/nl/071772944


    This article analyses the effects of access to flexible work arrangements, namely flexi-time, telehomework and part-time work, on employees’ satisfaction with the fit between paid work and private life and their overall job satisfaction. Having access to flexible work arrangements gives employees

  17. User Choice Resourcing Arrangements in Australia in March 2004. Working Paper No. 57

    Selby Smith, C.


    As part of a charge to assist the Australian National Training Authority (ANTA) to co-ordinate the development of relevant User Choice resourcing arrangements, CEET documented existing User Choice resourcing arrangements in each jurisdiction as of March 31, 2004. Emails were sent to each jurisdiction asking them to provide information on the User…

  18. Multiple Child Care Arrangements and Child Well Being: Early Care Experiences in Australia

    Claessens, Amy; Chen, Jen-Hao


    Nearly one quarter of Australian children under the age of 5 experience multiple non-parental child care arrangements. Research focused on the relationship between multiple child care arrangements and child socioemotional development is limited, particularly in Australia. Evidence from the United States and Europe has linked multiple child care…

  19. 40 CFR 267.36 - What arrangements must I make with local authorities for emergencies?


    ... PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE... equipment suppliers. (4) Arrangements to familiarize local hospitals with the properties of hazardous waste... arrangements, as appropriate, for the type of waste handled at your facility and the potential need for...

  20. X-ray examination apparatus with an imaging arrangement having a plurality of image sensors

    Slump, Cornelis H.; Harms, M.O.


    An imaging arrangement including a multi-sensor for use in an x-ray examination apparatus is described that combines a plurality of partially overlapping sub-images, resulting in an increased effective sensor area when compared to a single sensor-image. Thus an imaging arrangement is provided suitab

  1. X-ray examination apparatus with an imaging arrangement having a plurality of image sensors

    Slump, Cornelis H.


    An imaging arrangement including a multi-sensor for use in an x-ray examination apparatus is described that combines a plurality of partially overlapping sub-images, resulting in an increased effective sensor area when compared to a single sensor-image. Thus an imaging arrangement is provided suitab

  2. Developing Economic Arrangements for Water Resources Management : The potential of stakeholder oriented Water Valuation

    Hermans, L.M.; Halsema, van G.E.; Renault, D.


    As water is increasingly recognized as a scarce resource, the use of economic arrangements for water resources management seems increasingly promising. Experiences show that economic arrangements can contribute to a more efficient use of water resources but only if specific conditions are met, relat

  3. iNudgeYou does health nudge experiment on buffet arrangement

    Hansen, Pelle Guldborg


    By simply re-arranging the buffet serving 500 CEO’s we increased the intake of fruit by 84% and cut the intake of brownies by 30%.......By simply re-arranging the buffet serving 500 CEO’s we increased the intake of fruit by 84% and cut the intake of brownies by 30%....

  4. Institutional Arrangement of Financial Markets Supervision: The Case of the Czech Republic


    The paper deals with institutional arrangement of financial supervision in the Czech Republic. Financial markets are composed of partial financial segments specialized in individual types of financial instruments and individual customer groups. Financial institutions gradually transform into financial supermarkets. There are several models of institutional arrangement of financial supervision (integrated financial supervision model, sectional financial supervision model, financial supervision...

  5. Considerations for classroom seating arrangements and the role of teacher characteristics and beliefs

    Gremmen, Mariola; van den Berg, Y.H.M.; Segers, E.; Cillessen, A.H.N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4–6 of

  6. Considerations for classroom seating arrangements and the role of teacher characteristics and beliefs

    Gremmen, Mariola; van den Berg, Y.H.M.; Segers, E.; Cillessen, A.H.N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4–6 of eleme

  7. Considerations for classroom seating arrangements and the role of teacher characteristics and beliefs

    Gremmen, M.C.; Berg, Y.H.M. van den; Segers, P.C.J.; Cillessen, A.H.N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4-6 of eleme

  8. Considerations for Classroom Seating Arrangements and the Role of Teacher Characteristics and Beliefs

    Gremmen, Mariola C.; van den Berg, Yvonne H. M.; Segers, Eliane; Cillessen, Antonius H. N.


    As a part of classroom management, teachers face the question of how and where to seat their students. However, it is far from clear what considerations teachers have when making seating arrangements. Therefore, in this study seating arrangement considerations from 50 teachers in grades 4-6 of elementary school were assessed. In Phase 1, teachers…

  9. 29 CFR 779.232 - Franchise or other arrangements which create a larger enterprise.


    ... enterprise. 779.232 Section 779.232 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... Apply; Enterprise Coverage Leased Departments, Franchise and Other Business Arrangements § 779.232 Franchise or other arrangements which create a larger enterprise. (a) In other instances, franchise...

  10. 29 CFR 779.231 - Franchise arrangements which do not create a larger enterprise.


    ... enterprise. 779.231 Section 779.231 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... Apply; Enterprise Coverage Leased Departments, Franchise and Other Business Arrangements § 779.231 Franchise arrangements which do not create a larger enterprise. (a) While it is clear that in every...

  11. Reducing Insertion Sites of Penetrating Multipolar Shaft Electrodes by Double Side Electrode Arrangement


    Abstract-Micromachined devices with substrate-integrated elec- trodes are the key component in implantable microdevices for recording neuronal ...INSERTION SITES OF PENETRATING MULTIPOLAR SHAFT ELECTRODES BY DOUBLE SIDE ELECTRODE ARRANGEMENT T.Stieglitz1, P. Heiduschka2, M. Schuettler1, M. Gross1...and Subtitle Reducing Insertion Sites of Penetrating Multipolar Shaft Electrodes by Double Side Electrode Arrangement Contract Number Grant Number

  12. 46 CFR 199.153 - Survival craft launching and recovery arrangements using falls and a winch.


    ... falls and a winch. 199.153 Section 199.153 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... Requirements for All Vessels § 199.153 Survival craft launching and recovery arrangements using falls and a... appliances for free-fall launching arrangements, from a position within the survival craft. (b) Each...

  13. Arrangement of Book Materials in the Department for Children and Youth in a Public Library

    Katja Kemperle


    Full Text Available ABSTRACTPurpose:  The arrangement of books in libraries has been very important since their beginnings. In the departments for children and youth in Slovenian public libraries, several arrangement systems have been in use. In the 60's of the last century the CPM system was introduced. The system is based on dividing materials into three age groups. Lately, the need for changing this system has emerged. Two years ago Ljubljana City Library, Oton Župančič Library has introduced a new system for arranging materials for young readers. The main purpose of the article is to illustrate the reactions of other librarians to these changes and to find out if and how children's librarians use guidelines for the arrangement of materials. Methodology/approach:  Survey questionnaires were distributed to participants at the meeting titled »Librarians answer to the contemporary reading scene: the presentation of test arrangement of materials for children and youth in the Oton Župančič Library, a unit of the Ljubljana City Library (LCL«.  Results:  Visitors of that meeting reacted positively to the new arrangement system. 77 % of them are prepared to adopt and use it in their libraries. The results also show that librarians have already included some additional groups for arranging materials, within the CPM system. 90 % of librarians that answered the survey have modified the arrangement in their libraries or at least they use additional spine labels.  Research limitation:  Due to the small sample we can only assume that the results of the research reflect the general situation in Slovenian school libraries and youth departments of public libraries.   Originality/practical implications:  There is a need for restructuring and modernization of the current recommendations for the arrangement of book materials. The results also highlight the areas that should be given immediate priority and can support new solutions to the present arrangement system.

  14. Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids

    Isabel Baeza


    Full Text Available Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome and/or systemic lupus erythematosus and in those with preeclampsia; these antibodies have also been documented in an experimental murine model of lupus, in which they are associated with immunopathology. Here, we demonstrate the presence of antibodies against non-bilayer phospholipid arrangements containing mycolic acids in the sera of lepromatous leprosy (LL patients, but not those of healthy volunteers. The presence of antibodies that recognise these non-bilayer lipid arrangements may contribute to the hypergammaglobulinaemia observed in LL patients. We also found IgM and IgG anti-cardiolipin antibodies in 77% of the patients. This positive correlation between the anti-mycolic-non-bilayer arrangements and anti-cardiolipin antibodies suggests that both types of antibodies are produced by a common mechanism, as was demonstrated in the experimental murine model of lupus, in which there was a correlation between the anti-non-bilayer phospholipid arrangements and anti-cardiolipin antibodies. Antibodies to non-bilayer lipid arrangements may represent a previously unrecognised pathogenic mechanism in LL and the detection of these antibodies may be a tool for the early diagnosis of LL patients.

  15. Sleeping arrangement and house structure affect bed net use in villages along Lake Victoria

    Maekawa Yoshihide


    Full Text Available Abstract Background Although insecticide-treated bed nets are effective tools, use often does not follow ownership. House structure and space arrangements may make the attempt to use bed nets difficult, especially for school age children. The objectives of this study were to explore whether an individual's sleeping arrangements and house structure affect bed net use in villages along Lake Victoria in western Kenya. Methods Sleeping arrangements of residents were directly observed for use of a bed net, use of a bed, and location. House size, number and types of rooms, bed availability, and residents' ages were estimated. The family heads and mothers were asked about the reason for not using bed nets. Individual bed net use was examined against age and sleeping arrangement. Net use at the household level was examined against four variables: bed availability, bed net availability, house size, and number of rooms. Results Bed net use by children between five and 15 years of age was lower than that among the other age classes. However, age was dropped from the final model, and sleeping arrangement was significantly associated with net use. Net use was significantly associated with bed availability, number of rooms and their interaction. Conclusion Net use was affected by sleeping arrangement and availability of suitable locations for hanging nets, in addition to net availability. Most residents had likely not realized that sleeping arrangement was a factor in net use. The ease of hanging a net is particularly important for children.

  16. Living arrangements of the elderly and the sociodemographic and health determinants: a longitudinal study

    Alisson Fernandes Bolina

    Full Text Available ABSTRACT Objectives: to describe the sociodemographic characteristics and the number of morbidities in the elderly, according to the dynamics of living arrangements and evaluate the sociodemographic and health determinants of the living arrangements. Methods: this is a household longitudinal survey (2005-2012, carried out with 623 elderly people. Descriptive statistical analysis and multinomial logistic regression were performed (p<0.05. Results: there was predominance of elderly living alone, accompanied and with change in the living arrangements, females, age range between 60├ 70 years, 1├ 4 years of study and with income between 1├┤ 3 minimum wages. During the development of this research, it was identified an increase in the incidence of elderly with 1├┤3 minimum wages. The number of morbidities increased in the three groups throughout the study, with the highest rates observed among the elderly with change in the dynamics of living arrangements. It was found that elderly men showed less chance of living alone (p=0.007 and having change in the living arrangements compared to women (p = 0.005. Incomes less than a minimum wage decreased the chances of change in the living arrangements compared to incomes above three salaries (p=0.034. Conclusion: the determining factors of the living arrangements were sex and income, and the variables functional capacity and number of morbidities were not associated with the outcome analyzed.

  17. Genes and Gene Therapy

    ... correctly, a child can have a genetic disorder. Gene therapy is an experimental technique that uses genes to ... or prevent disease. The most common form of gene therapy involves inserting a normal gene to replace an ...

  18. Arrangement of anchor reinforcement in roadway for fully mechanized sublevel caving

    勾攀峰; 陈启永; 芦付松


    Bolting of mining roadway for fully mechanized sublevel caving has been practised successfully in Hebi mining area.It provides a new method for roadway support and settles the problem of support difficulty radically for sublevel caving in Hebi mining area.Where anchor reinforcement holds an important station in roadway support.This article brings forward the arrangement project of anchor based on theoretic analysis.Compared with arranged in the middle of the entry, anchor arranged in the vertex of the entry can reduces the length of anchor,shortens the anchor installation time,and heightens the reliability of anchor installation.

  19. Janus droplet parallel arrangements using a simple Y-channel flow-focusing microfluidic device

    Cheng, Long; Cai, Bo; Zuo, Yunfeng; Xiao, Liang; Rao, Lang; He, Zhaobo; Yang, Yi; Liu, Wei; Guo, Shishang; Zhao, Xing-Zhong


    Due to its unique advantages such as monodispersity and high throughput, droplet microfluidics has been widely used to generate diverse droplets/particles that have specific structures. Herein, we implemented Janus droplet parallel arrangements in a flow-focusing microchip through regulating corresponding fluid flow rates. Initially, fluorescence dye and PBS buffer solution kept laminar flow before the flow-focusing orifice and then was sheared into Janus droplets. Droplet diameter and corresponding generation frequency could be effectively manipulated. Subsequently, the generation of different Janus droplet parallel arrangements (e.g. monolayer, double-layer or three-layer arrangement) could be achieved by fluid regulation.

  20. Research on Corporate Right of Control:Mode of Arrangement and Innovation of Governance



    The mode of arrangement and innovation of governance for corporate rights of control should be in accordance with the global resource disposition opportunities and efficiency competition. Based on rights formulated by acts and regulations, this paper establishes models of arrangement for corporate rights of control, and then analyses the composite basic features derived from the models. To conclude, a main frame for the arrangement and innovation of corporate rights of control is put forward based on the real practice of listed companies in China.

  1. Social behaviors as determined by different arrangements of social consequences: diffusion of responsibility effects with competition.

    Guerin, Bernard


    According to a recently proposed synthesis, social loafing, social facilitation, and deindividuation can be viewed as different ways of arranging social consequences (B. Guerin, 1999). The effects of such arrangements have been measured in past research as productive output (social loafing and social facilitation) or as antinormative behaviors (deindividuation), but all 3 effects are manipulable by changing individual identifiability, evaluation, social identity, task difficulty, and presence in a group. The synthesis also predicted that these same variables would apply to other measures and other arrangements of social consequences. To this end, in the present 2 experiments, the author varied the arrangements for consequence diffusion in a competition situation by varying small and large competing groups and measured productive output and antinormative behaviors simultaneously. The 2 experiments showed social-consequence effects in competition situations with college students, giving further support for the social-consequence synthesis and the idea that the verbal naming of phenomena in social psychology is arbitrary.

  2. Allocation of public and-or private responsibilities. Governance arrangements for green roofs

    Mees, H.L.P.


    This research was commissioned by Knowledge for Climate, Hotspot Rotterdam Region (, and included an international comparison of governance arrangements for the promotion of green roofs as an innovative no-regrets mea

  3. What about the grandparents? Children's postdivorce residence arrangements and contact with grandparents

    Westphal, Sarah Katharina; Poortman, Anne Rigt; Van der Lippe, Tanja


    Despite the importance of grandparents in their grandchildren's lives, little is known about grandparent-grandchild contact after parental divorce. In this study, the authors investigated differences in grandparent-grandchild contact across 3 postdivorce residence arrangements (mother residence,

  4. Periodically arranged colloidal gold nanoparticles for enhanced light harvesting in organic solar cells

    Mirsafaei, Mina; Fernandes Cauduro, André Luis; Kunstmann-Olsen, Casper


    , which makes it possible to improve the light absorption and charge extraction in the device’s active layer. Here, periodically arranged colloidal gold nanoparticles are demonstrated experimentally and theoretically to improve light absorption and thus enhance the efficiency of organic solar cells....... Surface-ordered gold nanoparticle arrangements are integrated at the bottom electrode of organic solar cells. The resulting optical interference and absorption effects are numerically investigated in bulk hetero-junction solar cells based on the Finite-Difference Time-Domain (FDTD) and Transfer Matrix...... Method (TMM) and as a function of size and periodicity of the plasmonic arrangements. In addition, light absorption enhancement in the organic active layer is investigated experimentally following integration of the nanoparticle arrangements. The latter are fabricated using a lithography-free stamping...

  5. Computer-generated holograms using multiview images captured by a small number of sparsely arranged cameras.

    Ohsawa, Yusuke; Yamaguchi, Kazuhiro; Ichikawa, Tsubasa; Sakamoto, Yuji


    Computer-generated holograms (CGHs) using multiview images (MVIs) are holograms generated with multiple ordinary cameras. This process typically requires a huge number of cameras arranged at high density. In this paper, we propose a method to improve CGH using MVIs that obtains the MVIs by using voxel models rather than cameras. In the proposed method the voxel model is generated using the shape-from-silhouette (SFS) technique. We perform SFS using a small number of cameras arranged sparsely to create voxel models of objects and then generate the required number of images from these models by volume rendering. This enables us to generate CGHs using MVIs with just a small number of sparsely arranged cameras. Moreover, the proposed method arrange CGHs using MVIs at arbitrary positions.

  6. 26 CFR 1.401(k)-1 - Certain cash or deferred arrangements.


    ... applicable withholding requirements). See also section 414(h)(1). A designated Roth contribution, however, is... arrangement (including designated Roth contributions) are treated as employer contributions. Thus, for example... testing. Elective contributions (including elective contributions that are designated Roth...

  7. Distinguishing the cross-beta spine arrangements in amyloid fibrils using FRET analysis.

    Deng, Wei; Cao, Aoneng; Lai, Luhua


    The recently published microcrystal structures of amyloid fibrils from small peptides greatly enhanced our understanding of the atomic-level structure of the amyloid fibril. However, only a few amyloid fibrils can form microcrystals. The dansyl-tryptophan fluorescence resonance energy transfer (FRET) pair was shown to be able to detect the inter-peptide arrangement of the Transthyretin (105-115) amyloid fibril. In this study, we combined the known microcrystal structures with the corresponding FRET efficiencies to build a model for amyloid fibril structure classification. We found that fibrils with an antiparallel structural arrangement gave the largest FRET signal, those with a parallel arrangement gave the lowest FRET signal, and those with a mixed arrangement gave a moderate FRET signal. This confirms that the amyloid fibril structure patterns can be classified based on the FRET efficiency.

  8. Institutional Arrangements for Conservation, Development and Tourism in Eastern and Southern Africa : A Dynamic Perspective

    Duim, van der V.R.; Lamers, M.A.J.; Wijk, van J.J.


    This book describes and analyzes six novel conservation arrangements in eastern and southern Africa, illustrating how tourism is increasingly used and promoted as a key mechanism for achieving conservation and development objectives outside state-protected areas.

  9. Optimization of compartments arrangement of submarine pressure hull with knowledge based system

    Chung, Bo-Young; Kim, Soo-Young; Shin, Sung-Chul; Koo, Youn-Hoe; Kraus, Andreas


    This study aims to optimize an arrangement of ship compartments with knowledge-based systems. Though great attention has been shown to the optimization of hull forms in recent years, the study on arrangement design optimization has received relatively little attention. A ship is both an engineering system and a kind of assembly of many spaces. This means that, to design an arrangement of ship compartments, it is necessary to treat not only geometric data but also knowledge on topological relations between spaces and components of a ship. In this regard, we select a suitable knowledge representation scheme for describing ship compartments and their relations, and then develop a knowledge-based system using expert system shell. This new approach is applied to create design variations for optimization on an arrangement of a pressure hull of a submerged vehicle. Finally, we explicate how our approach improves the design process.

  10. The effect of alternative work arrangements on women's well-being: a demand-control model.

    Kelloway, E K; Gottlieb, B H


    The growth of women's participation in the labor force and evidence of the conflict they experience between job and family demands have spurred many employers to introduce alternative work arrangements such as flextime, job sharing, and telecommuting. Drawing on data gained from a sample of women (N = 998) in two large Canadian organizations, this study evaluates two mediational models of the impact of alternative work arrangements on women's stress and family role competence. Specifically, it tests and finds support for the hypotheses that (a) work arrangements involving scheduling flexibility (telecommuting and flextime) promote these aspects of women's well-being by increasing their perceived control over their time, and (b) arrangements involving reduced hours of employment (part-time employment and job sharing) promote well-being by reducing perceived job overload. Discussion of these findings centers on their implications for employed women, their employers, and future research.

  11. Resonant field enhancement in periodically arranged microslits for non-linear terahertz spectroscopy

    Pedersen, Pernille Klarskov; Iwaszczuk, Krzysztof; Zalkovskij, Maksim;

    We present a design of periodically arranged microslits in a gold film for nonlinear terahertz phonon spectroscopy.Global optimization of array parameters gives a field enhancement of more than 50, due to plasmonic coupling between individual slits....

  12. Optimization of Camera Arrangement Using Correspondence Field to Improve Depth Estimation.

    Fu, Shichao; Safaei, Farzad; Li, Wanqing


    Stereo matching algorithms attempt to estimate depth from the images obtained by two cameras. In most cases, the arrangement of cameras (their locations and orientations with respect to the scene) are determined based on human experience. In this paper, it is shown that the camera arrangement can be optimized using the concept of correspondence field (CF) for better acquisition of depth. Specifically, the paper demonstrates the relationship between the correspondence field of a pair of cameras and depth estimation accuracy and presents a method to optimize their arrangement based on the gradient of CF. The experimental results show that a pair of cameras optimized by the proposed method can improve the accuracy of depth estimation by as much as 30% compared to the conventional camera arrangements.

  13. Investigation of the optimal detector arrangement for the helmet-chin PET - A simulation study

    Ahmed, Abdella M.; Tashima, Hideaki; Yoshida, Eiji; Yamaya, Taiga


    High sensitivity and high spatial resolution dedicated brain PET scanners are in high demand for early diagnosis of neurodegenerative diseases and studies of brain functions. To meet the demand, we have proposed the helmet-chin PET geometry which has a helmet detector and a chin detector. Our first prototype scanner used 54 4-layer depth-of-interaction (DOI) detectors. The helmet detector of the scanner had three detector rings with different radii arranged on a surface of a hemisphere (with a radius of 126.5 mm) and a top cover detector. Therefore, in this study, for our next development, we propose a spherical arrangement, in which the central axis of each detector points toward the center of the hemisphere, and we optimize the size of the detector crystal block to be arranged on the helmet detector. We simulate the spherical arrangement with the optimized crystal block size and compare its imaging performance with the multi-ring arrangement, which has a similar detector arrangement to that of our first prototype. We conduct Monte Carlo simulation to model the scanners having the 4-layer DOI detectors which consist of LYSO crystals. A dead space of 2 mm is assumed on each side of the crystal blocks such as for wrapping. The size of the crystal block is varied from 4×4 mm2 to 54×54 mm2 while fixing the thickness of the crystal block to 20 mm. We find that the crystal block sized at 42×42 mm2 has the highest sensitivity for a hemispherical phantom. The comparison of the two arrangements with the optimized crystal blocks show that, for the same number of crystal blocks, the spherical arrangement has 17% higher sensitivity for the hemispherical phantom than the multi-ring arrangement. We conclude that the helmet-chin PET with the spherical arrangement constructed from the crystal block sized at 42×42×20 mm3 has better imaging performance especially at the upper part of the brain compared to the multi-ring arrangement while keeping similar spatial resolution

  14. 26 CFR 1.1402(a)-18 - Split-dollar life insurance arrangements.


    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Split-dollar life insurance arrangements. 1... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Tax on Self-Employment Income § 1.1402(a)-18 Split-dollar life insurance arrangements. See §§ 1.61-22 and 1.7872-15 for rules relating to the treatment of split...

  15. Flexible Working, Individual Performance and Employee Attitudes: Comparing Formal and Informal Arrangements

    Menezes, L. M.; kelliher, C


    In the context of a wider trend to individualize HRM, this paper examines the relationship between flexible working arrangements and individual performance. Drawing on a range of theories, it examines potential indirect effects on employee performance via job satisfaction and organizational commitment and analyses whether these relationships vary according to whether the arrangement was set up through a formal process, or negotiated informally between the employee and their line manager. Exta...

  16. Flexible Working, Individual Performance, and Employee Attitudes: Comparing Formal and Informal Arrangements

    De Menezes, Lilian M.; Kelliher, Clare


    In the context of a wider trend to individualize HRM, this paper examines the relationship between flexible working arrangements and individual performance. Drawing on a range of theories, it examines potential indirect effects on employee performance via job satisfaction and organizational commitment and analyses whether these relationships vary according to whether the arrangement was set up through a formal process, or negotiated informally between the employee and their line manager. Exta...

  17. Statistical Approaches in Analysis of Variance: from Random Arrangements to Latin Square Experimental Design


    Background: The choices of experimental design as well as of statisticalanalysis are of huge importance in field experiments. These are necessary tobe correctly in order to obtain the best possible precision of the results. Therandom arrangements, randomized blocks and Latin square designs werereviewed and analyzed from the statistical perspective of error analysis.Material and Method: Random arrangements, randomized block and Latinsquares experimental designs were used as field experiments. ...

  18. Electron microscopy observations of surface morphologies and particle arrangement behaviors of magnetic fluids

    沈辉; 徐雪青; 王伟


    The surface morphology of quasi-periodic stripe-shaped patterns of magnetite fluids was observed in applied perpendicular magnetic fields by means of scanning electron microscopy. The nanoparticles of the magnetite fluids are arranged in oriental quasilinear chains in applied perpendicular magnetic fields as observed using transmission electron microscopy. This arrangement results from particle-particle interactions and particle-carrier liquids interactions, which are eventually controlled by the magnetic fields distribution.

  19. On the local zeta functions and the b-functions of certain hyperplane arrangements

    Budur, Nero; Yuzvinsky, Sergey


    Conjectures of J. Igusa for p-adic local zeta functions and of J. Denef and F. Loeser for topological local zeta functions assert that (the real part of) the poles of these local zeta functions are roots of the Bernstein-Sato polynomials (i.e. the b-functions). We prove these conjectures for certain hyperplane arrangements, including the case of reduced hyperplane arrangements in three-dimensional affine space.

  20. Implementation arrangements for climate adaptation in the Netherlands: characteristics and underlying mechanisms of adaptive governance

    Arwin van Buuren


    Full Text Available Adaptation to climate change is a rapidly emerging policy domain. Over the last decade we have witnessed many attempts to enhance the climate robustness of agriculture, urban development, water systems, and nature to an increase in flood and drought risks due to a higher variability in rainfall patterns and sea level rise. In the vulnerable Dutch delta, regional authorities have developed adaptation measures that deal with flood risk, the availability of fresh water, subsidence, and salt water intrusion. In view of all the uncertainties that surround climate change, scientists emphasize that it should be possible to make changes when conditions change or insights evolve. The concept of adaptive governance has been introduced to facilitate the process of climate adaptation. Adaptive governance requires the availability of governance arrangements that facilitate adaptiveness by being flexible to enable adjustment. Although flexible arrangements for adaptation to climate change make sense from an adaptive governance perspective, from a more bureaucratic, political, and legal perspective, there might be good reasons to make arrangements as solid and robust as possible. In this article we answer the question to what extent the arrangements used to implement various adaptation measures are really adaptive and what mechanisms play a role in obstructing the accomplishment of adaptive arrangements. By analyzing and comparing nine adaptation cases, dealing with different climate issues, and the arrangements used to implement them from both a governance and a legal perspective, we are able to get more detailed insight into the main characteristics of the selected arrangements, their degree of adaptiveness, and the main hampering mechanisms for the creation or functioning of adaptive arrangements.

  1. Children's living arrangements following separation and divorce: insights from empirical and clinical research.

    Kelly, Joan B


    When parents separate, children typically enter into new living arrangements with each parent in a pattern determined most often by one or both parents or, failing private agreement, as a result of recommendations and decisions by lawyers, therapists, custody evaluators, or family courts. Most of these decisions have been based on cultural traditions and beliefs regarding postseparation parenting plans, visitation guidelines adopted within jurisdictions, unsubstantiated theory, and strongly held personal values and professional opinions, and have resulted since the 1960s in children spending most of their time with one residential parent and limited time with nonresident, or "visiting", parents. A large body of social science and child development research generated over the past three decades has identified factors associated with risk and resiliency of children after divorce. Such research remains largely unknown and untapped by parents and professionals making these crucial decisions about children's living arrangements. This article highlights empirical and clinical research that is relevant to the shape of children's living arrangements after separation, focusing first on what is known about living arrangements following divorce, what factors influence living arrangements for separated and divorced children, children's views about their living arrangements, and living arrangements associated with children's adjustment following divorce. Based on this research, it is argued that traditional visiting patterns and guidelines are, for the majority of children, outdated, unnecessarily rigid, and restrictive, and fail in both the short and long term to address their best interests. Research-based parenting plan models offering multiple options for living arrangements following separation and divorce more appropriately serve children's diverse developmental and psychological needs.

  2. Method for the removal of smut, fine dust and exhaust gas particles, particle catch arrangement for use in this method and use of the particle catch arrangement to generate a static electric field

    Ursem, W.N.J.; Marijnissen, J.C.; Roos, R.A.


    This inventions provides a method for the removal of smut, fine dust and exhaust gas particles from polluted air comprising providing a particle catch arrangement with a charged surface, the particle catch arrangement being arranged to generate a static electric field, wherein the electric field is

  3. A novel mitochondrial gene order in shorebirds (Scolopacidae, Charadriiformes)

    Verkuil, Yvonne I.; Piersma, Theunis; Baker, Allan J.


    Although the mitochondrial genome in birds has highly conserved features, with protein genes similar to mammals and amphibians, several variations in gene order around the hypervariable control region have been found. Here we report a novel gene arrangement around the control region in shorebirds (C

  4. An ergonomics based design research method for the arrangement of helicopter flight instrument panels.

    Alppay, Cem; Bayazit, Nigan


    In this paper, we study the arrangement of displays in flight instrument panels of multi-purpose civil helicopters following a user-centered design method based on ergonomics principles. Our methodology can also be described as a user-interface arrangement methodology based on user opinions and preferences. This study can be outlined as gathering user-centered data using two different research methods and then analyzing and integrating the collected data to come up with an optimal instrument panel design. An interview with helicopter pilots formed the first step of our research. In that interview, pilots were asked to provide a quantitative evaluation of basic interface arrangement principles. In the second phase of the research, a paper prototyping study was conducted with same pilots. The final phase of the study entailed synthesizing the findings from interviews and observational studies to formulate an optimal flight instrument arrangement methodology. The primary results that we present in our paper are the methodology that we developed and three new interface arrangement concepts, namely relationship of inseparability, integrated value and locational value. An optimum instrument panel arrangement is also proposed by the researchers. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  5. Relationship outcomes in Indian-American love-based and arranged marriages.

    Regan, Pamela C; Lakhanpal, Saloni; Anguiano, Carlos


    The meaning and purpose of marriage, and the manner in which spouses are selected, varies across cultures. Although many cultures have a tradition of arranged marriage, researchers interested in marital dynamics generally have focused on love-based marriages. Consequently, there is little information on relational outcomes within arranged marriages. This study compared relationship outcomes in love-based and arranged marriages contracted in the U.S. A community sample of 58 Indian participants living in the U.S. (28 arranged marriages, 30 love-based marriages) completed measures of marital satisfaction, commitment, companionate love, and passionate love. Men reported greater amounts of commitment, passionate love, and companionate love than women. Unexpectedly, no differences were found between participants in arranged and love-based marriages; high ratings of love, satisfaction, and commitment were observed in both marriage types. The overall affective experiences of partners in arranged and love marriages appear to be similar, at least among Indian adults living in contemporary U.S. society.

  6. A preliminary study on the definitions and differences of main types of business arrangements

    Anderson Tiago Peixoto Gonçalves


    Full Text Available With the growth of competitiveness and market requirements, several companies have been jointly organized with the aim of forming partnerships, forming the so-called Business Arrangements, to ensure that competitive advantages are achieved. This article came from the need to review the definitions and differences between the main types of existing Business Arrangements, as in the literature have been used different nomenclatures and classifications, either in terms of how the Arrangement is managed, how it is organized, the according to which members carry out their activities, how is the flow of resources and information, the degree of coordination and interaction, the form of production organization, and the strategies adopted. It is a basic research, descriptive and literature, which sought to collect the relevant sources, definitions about each Arrangement to meet the goal of the article is to study the definitions and differences between the main types of Business Arrangements. The article is justified by the scarcity of uniform definitions in the literature that make it possible to visualize the differences between each of the types of Arrangements, especially those in which the definitions are more similar.

  7. Transcription profiling of immune genes during parasite infection in susceptible and resistant strains of the flour beetles (Tribolium castaneum).

    Zhong, Daibin; Wang, Mei-Hui; Pai, Aditi; Yan, Guiyun


    The flour beetle, Tribolium castaneum, is an intermediate host for the tapeworm Hymenolepis diminuta and has become an important genetic model to explore immune responses to parasite infection in insect hosts. The present study examined the immune responses to tapeworm infection in resistant (TIW1) and susceptible (cSM) strains of the red flour beetle, T. castaneum, using real-time quantitative reverse transcription PCR on 29 immunity-related genes that exhibit antimicrobial properties. Thirteen of the 29 genes showed constitutive differences in expression between the two strains. Fourteen to fifteen of the 29 genes exhibited significant differences in transcription levels when beetles were challenged with tapeworm parasite in the resistant and susceptible strains. Nine genes (GNBP3, cSPH2, lysozyme4, defensin1, PGRP-SA, defensin2, coleoptericin1, attacin2 and serpin29) in cSM and 13 genes (lysozyme2, proPO1, GNBP3, cSPH2, lysozyme4, defensin1, PGRP-SA, defensin2, coleoptericin1, attacin2, proPO2/3, PGRP-LE and PGRP-SB) in TIW1 were up-regulated by infections or showed parasite infection-induced expression. Seven genes (attacin2, coleoptericin1, defensin1, defensin2, lysozyme2, PGRP-SA and PGRP-SB) were more than 10 folds higher in the resistant TIW1 strain than in the susceptible cSM strain after exposure to tapeworm parasites. This study demonstrated the effects of genetic background, the transcription profile to parasite infection, and identified the immunity-related genes that were significantly regulated by the infection of tapeworms in Tribolium beetles.

  8. Fluorescence in situ hybridization and optical mapping to correct scaffold arrangement in the tomato genome.

    Shearer, Lindsay A; Anderson, Lorinda K; de Jong, Hans; Smit, Sandra; Goicoechea, José Luis; Roe, Bruce A; Hua, Axin; Giovannoni, James J; Stack, Stephen M


    The order and orientation (arrangement) of all 91 sequenced scaffolds in the 12 pseudomolecules of the recently published tomato (Solanum lycopersicum, 2n = 2x = 24) genome sequence were positioned based on marker order in a high-density linkage map. Here, we report the arrangement of these scaffolds determined by two independent physical methods, bacterial artificial chromosome-fluorescence in situ hybridization (BAC-FISH) and optical mapping. By localizing BACs at the ends of scaffolds to spreads of tomato synaptonemal complexes (pachytene chromosomes), we showed that 45 scaffolds, representing one-third of the tomato genome, were arranged differently than predicted by the linkage map. These scaffolds occur mostly in pericentric heterochromatin where 77% of the tomato genome is located and where linkage mapping is less accurate due to reduced crossing over. Although useful for only part of the genome, optical mapping results were in complete agreement with scaffold arrangement by FISH but often disagreed with scaffold arrangement based on the linkage map. The scaffold arrangement based on FISH and optical mapping changes the positions of hundreds of markers in the linkage map, especially in heterochromatin. These results suggest that similar errors exist in pseudomolecules from other large genomes that have been assembled using only linkage maps to predict scaffold arrangement, and these errors can be corrected using FISH and/or optical mapping. Of note, BAC-FISH also permits estimates of the sizes of gaps between scaffolds, and unanchored BACs are often visualized by FISH in gaps between scaffolds and thus represent starting points for filling these gaps.

  9. GROTESQUE: Complex Geometric Arrangement of Unreflected HEU (93.15) Metal Pieces

    Mackenzie L. Gorham; John D. Bess


    The GROTESQUE experiments were designed specifically to develop and test neutronics for the GEOM subroutine of the 05R code. Two complex arrangements of various highly enriched uranium metal cylinders, rectangular parallelepipeds, and spheres were arranged in a circular formation on a steel diaphragm. A centerpiece was raised remotely through a hole in the steel diaphragm to achieve criticality. The first arrangement consisted of five major units, each major unit consisting of a stack of smaller uranium pieces. The second arrangement utilized nine major units, again consisting of stacks of smaller uranium pieces. The 9-unit arrangement is the only experiment discussed in this evaluation, since the five stack experiment never achieved criticality. The 9-unit arrangement is shown in Figure 1.1. The experiments were performed at the Oak Ridge Critical Experiments Facility (ORCEF) in June 1964. The 9-unit configuration was later used as part of the development process for early versions of KENO and a model representing a variation of this experiment (Sample Problem 7: GROTESQUE without the Diaphragm) is released with modern versions of SCALE for testing the proper installation of the KENO module. An experimental report for the GROTESQUE experiment has not been published; however there are two publications that describe the experiment (References 1 and 2). A separate reportc discussing the conversion of the 05r model into a KENO model was published; however, the author did not consult with the experimenter for GROTESQUE. This report is considered unreliable (except for dimensions) by the experimenter and should not be used to obtain information pertinent to the GROTESQUE experiment. The Oak Ridge Critical Experiments Facility (ORCEF) Logbook 15r contains the primary documentation from the experimenter for this experiment. The GROTESQUE arrangement of nine major units was evaluated an determined to be an acceptable benchmark experiment.

  10. Examination of Coil Arrangement for Higher Quality Heating of the Induction Heating Cooker

    Yonetsu, Daigo; Kawata, Kohei; Hara, Takehisa; Ujiie, Satoshi; Joto, Takaya; Masuda, Tadashi

    This paper proposes effective and practical design method of higher quality heating for induction-heating cooker. The IH cooker which has the simple pancake-shaped coil arrangement produces slightly nonuniform temperature distribution along the heating plate. The object of this research is to achieve the better heating performance by adjusting the arrangement of the coil. Easiness of coil winding is added to the evaluation basis. Eddy current analysis is made by the finite element method for calculating the heat distribution of the heating plate. After this, heat transfer analysis is made by the finite element method for calculating the temperature distribution of the heating plate. Multi-objective genetic algorithm is employed for obtaining the optimum arrangement of the coil. The two objectives that mean the uniformity of temperature distribution and the easiness of coil winding are both evaluated. By using the proposed method, we could obtain the expected coil arrangement easily. The temperature distribution approaches closer to uniform distribution by using the obtained coil arrangement which is not difficult to wind.

  11. Diversification of seed arrangement induced by ovule rotation and septum formation in Leguminosae.

    Endo, Yasuhiko; Ohashi, Hiroyoshi


    The plants of Leguminosae, which comprises 731 genera, bear monocarpellary flowers. The fruit, known as a pod, generally contains a row of seeds, and the internal structure appears to be simple. In Leguminosae, the seeds are generally arranged longitudinally along the suture of the pod but, in a few genera, namely, Cassia, Indigofera, and Senna, they are arranged transversely. Transverse seed arrangement facilitates the accommodation of a considerable number of seeds and has been considered to be established by rotation of seeds during development. We studied the development both these patterns of seed arrangement, i.e., longitudinal and transverse, in Senna and Indigofera in order to elucidate the structural changes occurring in ovaries (or pods) and determine the forces responsible for rotation of ovules (or seeds) by dissecting ovaries and pods at different developmental stages. Our results showed that at an early developmental stage the ovules were obliquely oriented or transversely arranged; later, the direction of their growth was restricted by the ovary walls or neighboring ovules, and therefore the obliquely oriented ovules rotated inward or outward. Thus, it was clarified that the processes involved in the formation of the internal structure of pods are regulated in a complex manner.

  12. Cigarette smoking and alcohol consumption among Chinese older adults: do living arrangements matter?

    Zhang, Jiaan; Wu, Liyun


    This study used five waves of the Chinese Longitudinal Healthy Longevity Survey to examine the relationship between living arrangements, smoking, and drinking among older adults in China from 1998-2008. We found that living arrangements had strong implications for cigarette smoking and alcohol consumption among the elderly. First, the likelihood of smoking was lower among older men living with children, and older women living either with a spouse, or with both a spouse and children; and the likelihood of drinking was lower among both older men, and women living with both a spouse and children, compared with those living alone. Second, among dual consumers (i.e., being a drinker and a smoker), the amount of alcohol consumption was lower among male dual consumers living with children, while the number of cigarettes smoked was higher among female dual consumers living with others, compared with those living alone. Third, among non-smoking drinkers, the alcohol consumption was lower among non-smoking male drinkers in all types of co-residential arrangements (i.e., living with a spouse, living with children, living with both a spouse and children, or living with others), and non-smoking female drinkers living with others, compared with those living alone. Results highlighted the importance of living arrangements to cigarette smoking and alcohol consumption among Chinese elderly. Co-residential arrangements provided constraints on Chinese older adults' health-risk behaviors, and had differential effects for men and women.

  13. Cigarette Smoking and Alcohol Consumption among Chinese Older Adults: Do Living Arrangements Matter?

    Jiaan Zhang


    Full Text Available This study used five waves of the Chinese Longitudinal Healthy Longevity Survey to examine the relationship between living arrangements, smoking, and drinking among older adults in China from 1998–2008. We found that living arrangements had strong implications for cigarette smoking and alcohol consumption among the elderly. First, the likelihood of smoking was lower among older men living with children, and older women living either with a spouse, or with both a spouse and children; and the likelihood of drinking was lower among both older men, and women living with both a spouse and children, compared with those living alone. Second, among dual consumers (i.e., being a drinker and a smoker, the amount of alcohol consumption was lower among male dual consumers living with children, while the number of cigarettes smoked was higher among female dual consumers living with others, compared with those living alone. Third, among non-smoking drinkers, the alcohol consumption was lower among non-smoking male drinkers in all types of co-residential arrangements (i.e., living with a spouse, living with children, living with both a spouse and children, or living with others, and non-smoking female drinkers living with others, compared with those living alone. Results highlighted the importance of living arrangements to cigarette smoking and alcohol consumption among Chinese elderly. Co-residential arrangements provided constraints on Chinese older adults’ health-risk behaviors, and had differential effects for men and women.

  14. Effects of patch contrast and arrangement on benefits of clonal integration in a rhizomatous clonal plant

    Wang, Yong-Jian; Shi, Xue-Ping; Wu, Xiao-Jing; Meng, Xue-Feng; Wang, Peng-Cheng; Zhou, Zhi-Xiang; Luo, Fang-Li; Yu, Fei-Hai


    The availabilities of light and soil water resources usually spatially co-vary in natural habitats, and the spatial pattern of such co-variation may affect the benefits of physiological integration between connected ramets of clonal plants. In a greenhouse experiment, we grew connected or disconnected ramet pairs [consisting of a proximal (relatively old) and a distal (relative young) ramet] of a rhizomatous herb Iris japonica in four heterogeneous environments differing in patch arrangement (reciprocal vs. parallel patchiness of light and soil water) and patch contrast (high vs. low contrast of light and water). Biomass of the proximal part, distal part and clonal fragment of I. japonica were all significantly greater in the intact than in the severed treatment, in the parallel than in the reciprocal patchiness treatment and in the high than in the low contrast treatment, but the effect of severing the connection between ramet pairs did not depend on patch arrangement or contrast. Severing the connection decreased number of ramets of the distal part and the clonal fragment in the parallel patchiness arrangement, but not in the reciprocal patchiness arrangement. Therefore, the spatial arrangement of resource patches can alter the effects of clonal integration on asexual reproduction in I. japonica. PMID:27759040

  15. Arranged Marriage

    Richard, Alan


    People in the rolling, scenic valley, between the Ozarks and Ouchita mountains have a lot in common. As of this school year, they share something else in common: a school district. The four districts that make up the newly christened Two Rivers are among 57 rural Arkansas systems that state lawmakers forced to consolidate with their neighbors.…

  16. Harmonious Arrangements.

    Estey, Gretta P.; Wilkerson, Steve


    Both centralized and decentralized college or university development programs have advantages, depending on the nature and needs of the institution. Changing program structure may have consequences that reach far beyond fund-raising details. A survey of 10 institutions revealed some common characteristics and many hybrid forms of organization.…

  17. Periodically arranged colloidal gold nanoparticles for enhanced light harvesting in organic solar cells

    Mirsafaei, Mina; Fernandes Cauduro, André Luis; Kunstmann-Olsen, Casper

    of thinner devices without compromising light absorption. In this work, we theoretically and experimentally investigate periodically arranged colloidal gold nanoparticles in organic solar cells, and demonstrate the use of such nanostructures to improve the light absorption in and thus the efficiency...... nanostructures as well as the period of the periodical arrangements in organic bulk hetero-junction solar cells. In addition, we investigate experimentally the light absorption enhancement in the organic active layer by incorporating surface-ordered gold nanoparticle arrangements at the bottom of the organic...... active layer. The latter are fabricated with a lithography-free stamp technique, creating a centimeter scaled area with defined inter-particle spacing. Our study presents the light harvesting ability of template-assisted nanoparticle assemblies in organic solar cells and as the approach is easily...

  18. Relevance of pre-contractual arrangements for jurisdiction and merits in international investment arbitration

    Đajić Sanja


    Full Text Available In this article the author discusses the issue whether pre-contractual arrangements and pre-investment expenditures may qualify for an investment within the meaning of applicable legal framework. The answer to this question is relevant for jurisdiction of investment tribunals. Chronological overview of cases dealing with pre-contractual arrangements demonstrates the shift from the original position according to which pre-investment expenditures do not amount to an investment to the understanding that pre-contractual arrangement may amount to an investment under certain circumstances, such as extensive definitions of an investment coupled with the existing investment in the host country. While there has been a significant shift recently which favored jurisdiction of investment tribunals, the established position of majority of tribunals in denying claims for loss of profits on the basis of failed commercial transactions remained unchanged.

  19. Influence of arrangement field on magnetostrictive and mechanical properties of magnetostrictive composites

    DONG Xu-feng; GUAN Xin-chun; QI Min; OU Jin-ping


    Non-aligned and aligned polymer-bonded Tb_(0.3)Dy_(0.7)Fe_2 composites with 20% particle volume fraction were prepared under different arrangement fields (I.e.0,10 kA/m,20 kA/m,30 kA/m,60 kA/m and 100 kA/m) during their gel process.Static magnetostriction,dynamic magnetostriction,elastic modulus and compressive strength of all specimens were tested and compared.Experimental results indicate that all the parameters are positively dependent on the arrangement field.The dependence is significant at low field levels,the critical value of which is 30 kA/m for the composites fabricated.No obvious improvement of the properties can be observed for a larger field.Such critical values are defined as the optimal arrangement field to manufacture magnetostrictive composites.

  20. Performance model of metallic concentric tube recuperator with counter flow arrangement

    Sharma, Harshdeep; Kumar, Anoop; Goel, Varun


    A performance model for counter flow arrangement in concentric tube recuperator that can be used to utilize the waste heat in the temperature range of 900-1,400°C is presented. The arrangement consists of metallic tubular inner and outer concentric shell with a small annular gap between two concentric shells. Flue gases pass through the inner shell while air passes through the annular gap in the reverse direction (counter flow arrangement). The height of the recuperator is divided into elements and an energy balance is performed on each elemental height. Results give necessary information about surface, gas and air temperature distribution, and the influence of operating conditions on recuperator performance. The recuperative effectiveness is found to be increased with increasing inlet gas temperature and decreased with increasing fuel flow rate. The present model accounts for all heat transfer processes pertinent to a counterflow radiation recuperator and provide a valuable tool for performance considerations.

  1. Observation of a surface lattice resonance in a fractal arrangement of gold nanoparticles

    Chen, Ting Lee; Segerink, Frans B; Dikken, Dirk Jan; Herek, Jennifer L


    The collective response of closely spaced metal particles in non-periodic arrangements has the potential to provide a beneficial angular and frequency dependence in sensing applications. In this paper, we investigate the optical response of a Sierpinski fractal arrangement of gold nanoparticles and show that it supports a collective resonance similar to the surface lattice resonances that exist in periodic arrangements of plasmonic resonators. Using back focal plane microscopy, we observe the leakage of radiation out of a surface lattice resonance that is efficiently excited when the wavenumber of the incident light matches a strong Fourier component of the fractal structure. The efficient coupling between localized surface plasmons leads to a collective resonance and a Fano-like feature in the scattering spectrum. Our experimental observations are supported by numerical simulations based on the coupled-dipole approximation and finite-difference time-domain methods. This work presents a first step towards the...

  2. Work-life balance and the legal right to request flexible working arrangements

    L Dancaster


    Full Text Available In 2003, eligible employees in the United Kingdom acquired the legal right to request flexible working arrangements. The government believes that this new right will provide parents with greater choice and support in balancing work and childcare, whilst being compatible with business efficiency. This article critically appraises this new right and examines how it is applied in relation to other UK legislation on discrimination and unfair dismissal. An overview of international studies on corporate efforts to introduce family-friendly arrangements, and an overview of governmental efforts to address the reconciliation of work and family-life is provided in this article, with a view to arguing that there is a need, in South Africa, for state policy regarding work-life balance and for further research into corporate efforts to introduce family-friendly work arrangements.

  3. Gas turbine structural mounting arrangement between combustion gas duct annular chamber and turbine vane carrier

    Wiebe, David J.; Charron, Richard C.; Morrison, Jay A.


    A gas turbine engine ducting arrangement (10), including: an annular chamber (14) configured to receive a plurality of discrete flows of combustion gases originating in respective can combustors and to deliver the discrete flows to a turbine inlet annulus, wherein the annular chamber includes an inner diameter (52) and an outer diameter (60); an outer diameter mounting arrangement (34) configured to permit relative radial movement and to prevent relative axial and circumferential movement between the outer diameter and a turbine vane carrier (20); and an inner diameter mounting arrangement (36) including a bracket (64) secured to the turbine vane carrier, wherein the bracket is configured to permit the inner diameter to move radially with the outer diameter and prevent axial deflection of the inner diameter with respect to the outer diameter.

  4. Coal mining with Triple-section extraction process in stagger arrangement roadway layout method

    Cui, Zimo; Liu, Baozhu; Zhao, Jingli; Chanda, Emmanuel


    This paper introduces the Triple-section extraction process in the three-dimensional roadway layout of stagger arrangement method for longwall top-coal caving mining. This 3-D roadway layout of stagger arrangement method without coal pillars, which arranged the air intake roadway and air return roadway in different horizons, realizing the design theory transformation of roadway layout from 2D system to 3D system. And the paper makes systematic analysis to the geological, technical and economic factors, applies this new mining roadway layout technology for raising coal recovery ratio and solving the problems about full-seam mining in thick coal seam synthetically according to theoretical study and mining practice. Furthermore, the paper presents a physical simulation about inner staggered roadway layout of this particular longwall top-coal caving method.

  5. Numerical Study of Atmospheric Icing on Non Rotating Circular Cylinders in Tandem Arrangement

    Muhammad S. Virk


    Full Text Available Numerical study of atmospheric ice accretion on two non-rotating circular cylinders in tandem arrangement was carried out at different operating and geometric conditions. To validate the numerical model, initially the results of ice accretion on single circular cylinder were compared with the experimental data obtained from CIGELE atmospheric icing research wind tunnel (CAIRWT [1, 2]. A good agreement was found between experimental and numerical results. Numerical analyses of ice accretion on two circular cylinders in tandem arrangement showed that accreted ice loads decreases with the increase in distance between the cylinders and also affects the rate and shape of ice accretion. Parametric study at different droplet sizes and temperatures showed a significant change in ice accretion. This research work provides a useful base for better understanding and further investigation of atmospheric ice accretion on circular overhead power network cables in tandem arrangement, installed in the cold regions.

  6. Controlling DNA Bundle Size and Spatial Arrangement in Self-assembled Arrays on Superhydrophobic Surface

    Gabriele Ciasca; Luca Businaro; Marco De Spirito; Massimiliano Papi; Valentina Palmieri; Michela Chiarpotto; Simone Di Claudio; Adele De Ninno; Ennio Giovine; Gaetano Campi; Annamaria Gerardino


    The use of superhydrophobic surfaces (SHSs) is now emerging as an attractive platform for the realization of one-dimensional (1D) nanostructures with potential applications in many nanotechnological and biotechnological fields. To this purpose, a strict control of the nanostructures size and their spatial arrangement is highly required. However, these parameters may be strongly dependent on the complex evaporation dynamics of the sessile droplet on the SHS. In this work, we investigated the effect of the evaporation dynamics on the size and the spatial arrangement of self-assembled 1D DNA bundles. Our results reveal that different arrangements and bundle size distributions may occur depending on droplet evaporation stage. These results contribute to elucidate the formation mechanism of 1D nanostructures on SHSs.

  7. Triple-wavelength infrared plasmonic thermal emitter using hybrid dielectric materials in periodic arrangement

    Huang, Wei-Lun; Hsiao, Hui-Hsin; Tang, Ming-Ru; Lee, Si-Chen


    This paper presents a triple-wavelength infrared plasmonic thermal emitter using a periodic arrangement of hybrid dielectric materials within a tri-layer metal/dielectric/metal structure. The proposed arrangement makes it possible to sustain multiple resonance of localized surface plasmons (LSP), thereby providing an additional degree of freedom by which to vary the resonant wavelengths in the medium infrared region. Variations in the effective refractive index due to the different modal distribution within dielectric gratings results in multiple LSP resonances, and the resonant wavelengths can be easily tuned by altering the compositions of hybrid dielectric materials. The measured dispersion relation diagram and the finite difference time domain simulation indicated that the resonances were localized. They also indicate that the magnetic fields generated by the multiple LSP modes exhibit distribution patterns similar to that of a standing wave in the periodic arrangement of the hybrid dielectric layer, each of which presents an emission peak corresponding to a different modal order.

  8. Practical method using superposition of individual magnetic fields for initial arrangement of undulator magnets.

    Tsuchiya, K; Shioya, T


    We have developed a practical method for determining an excellent initial arrangement of magnetic arrays for a pure-magnet Halbach-type undulator. In this method, the longitudinal magnetic field distribution of each magnet is measured using a moving Hall probe system along the beam axis with a high positional resolution. The initial arrangement of magnetic arrays is optimized and selected by analyzing the superposition of all distribution data in order to achieve adequate spectral quality for the undulator. We applied this method to two elliptically polarizing undulators (EPUs), called U#16-2 and U#02-2, at the Photon Factory storage ring (PF ring) in the High Energy Accelerator Research Organization (KEK). The measured field distribution of the undulator was demonstrated to be excellent for the initial arrangement of the magnet array, and this method saved a great deal of effort in adjusting the magnetic fields of EPUs.

  9. Development of a triggering arrangement for the KALI-30GW MARX generator

    Mitra, S.; Kolge, T. S.; Agarwal, Ritu; Saroj, P. C.; Patel, Ankur; Senthil, K.; Sharma, Vishnu; Tewari, S. V.; Sharma, Archana; Mittal, K. C.


    This paper reports the design methodology and implementation experiments for a solid-state-based triggering arrangement for the MARX generator of the KALI-30GW (1 MV, 30 kA, 80 ns) pulsed power system. The 15-stage bipolar MARX generator of the KALI-30GW system is triggered using a trigatron-type spark gap. An insulated-gate bipolar-transistor (IGBT)-based trigger supply is used to trigger the first spark gap, and the next two spark gaps are triggered by using internally-generated trigger pulses. Optically-isolated arrangements are provided for a human interface. The entire assembly was tested with a dummy copper sulphate load, and an excellent triggering range of 7-12 kV was achieved. The circuit diagram, analysis and experimental results of the triggering arrangement are presented in the paper.

  10. Responding to environmental regulations through collaborative arrangements: Social aspects of manure partnerships in Denmark

    Asai, Masayasu; Langer, Vibeke; Frederiksen, Pia


    nutrients, in order to manage the manure resource at landscape scale and comply with environmental regulations. The extent of collaborative arrangements for manure among Danish farms was explored at national scale using registry data. This showed that in 2009, 50% of all farms in Denmark, managing 70...... the arrangement, either through family, neighbours or their local or professional network. These different social relations played an important role in defining four types of partnerships, differing in e.g. burden sharing of manure transportation and spreading, frequency of communication and transport distance......In livestock-intensive regions of Europe, on-farm application of manure and other fertilisers is being increasingly regulated to protect aquatic environments. This study examined collaborative arrangements between intensive livestock farms in Denmark with surplus manure and farms requiring crop...

  11. Institutional arrangements for the reduction of proliferation risks formulation, evaluation, and implementation of institutional concepts

    Kratzer, M.B.; Wonder, E.F.; Gray, J.E.; Shantzis, S.B.; Sievering, N.F.; Paige, H.W.; Jones, B.M.


    The purpose of this study was to: (1) identify alternative institutional arrangements applicable to the sensitive steps in the back-end of the fuel cycle that might reduce their associated proliferation risks; and (2) assess their advantages and disadvantages from the standpoint of nonproliferation effectiveness and political, economic, and operational acceptability. The concept of international or multinational custody of sensitive materials and facilities was found to offer a high degree of proliferation resistance and to likely be more acceptable to prospective participants than other institutional arrangements that intrude upon proprietary areas, such as facility ownership and management.

  12. Wurdi Youang: an Australian Aboriginal stone arrangement with possible solar indications

    Norris, Ray P; Hamacher, Duane W; Abrahams, Reg


    Wurdi Youang is an egg-shaped Aboriginal stone arrangement in Victoria, Australia. Here we present a new survey of the site, and show that its major axis is aligned within a few degrees of east-west. We confirm a previous hypothesis that it contains alignments to the position on the horizon of the setting sun at the equinox and the solstices, and show that two independent sets of indicators are aligned in these directions. We show that these alignments are unlikely to have arisen by chance, and instead the builders of this stone arrangement appear to have deliberately aligned the site on astronomically significant positions.

  13. The impact of spatial arrangements on epidemic disease dynamics and intervention strategies

    Kelly, Michael R.; Tien, Joseph H.; Eisenberg, Marisa C.; Lenhart, Suzanne


    The role of spatial arrangements on the spread and management strategies of a cholera epidemic is investigated. We consider the effect of human and pathogen movement on optimal vaccination strategies. A metapopulation model is used, incorporating a susceptible–infected–recovered system of differential equations coupled with an equation modelling the concentration of Vibrio cholerae in an aquatic reservoir. The model compared spatial arrangements and varying scenarios to draw conclusions on how to effectively manage outbreaks. The work is motivated by the 2010 cholera outbreak in Haiti. Results give guidance for vaccination strategies in response to an outbreak. PMID:26981710

  14. Assessment of a Solar Cell Panel Spatial Arrangement Influence on Electricity Generation

    Anisimov, I. A.; Burakova, L. N.; Burakova, A. D.; Burakova, O. D.


    The research evaluates the impact of the spatial arrangement of solar cell panels on the amount of electricity generated (power generated by solar cell panel) in Tyumen. Dependences of the power generated by the solar panel on the time of day, air temperature, weather conditions and the spatial arrangement are studied. Formulas for the calculation of the solar cell panel inclination angle which provides electricity to urban infrastructure are offered. Based on the data in the future, changing of inclination angle of solar cell panel will be confirmed experimentally during the year in Tyumen, and recommendations for installing solar cell panels in urban infrastructure will be developed.

  15. Linear arrangement of hypopigmented Spitz nevi on the ear after trauma.

    Wang, Lei; Wang, Gang; Fan, Pingshen; Gao, Tianwen


    A 10-year-old boy had multiple papules after surgery on a primary lesion on his left ear. The papules were pink and showed a linear arrangement around the helix. Histopathological examination of two separate lesions showed proliferation of epithelioid cells in the dermis and some of them formed nests. No melanin was found in the epithelioid cells, and immunohistochemistry staining with S100, HMB45 and Melan-A were positive in the neoplasm cells. According to the clinical and histopathological characteristics, it was diagnosed as hypopigmented Spitz nevi with linear arrangement after trauma.

  16. Discounting and per diem arrangements lock in patient referrals. Part 2.

    Porn, L; Manning, M


    Discounting and per diem arrangements are the most popular payment methods used by hospitals today because they are relatively simple methods. A properly negotiated discount or per diem contract can provide a hospital with the opportunity to lock in patient referrals from the many healthcare providers in its local markets. This article is the second in a three-part series on the strategic pricing of healthcare services. The final article discusses the intricacies of capitation arrangements, an increasingly popular payment method for healthcare services.

  17. Optimization of Magnet Arrangement in Double-Layer Interior Permanent-Magnet Motors

    Yamazaki, Katsumi; Kitayuguchi, Kazuya

    The arrangement of permanent magnets in double-layer interior permanent-magnet motors is optimized for variable-speed applications. First, the arrangement of magnets is decided by automatic optimization. Next, the superiority of the optimized motor is discussed by the d- and q-axis equivalent circuits that consider the magnetic saturation of the rotor core. Finally, experimental verification is carried out by using a prototype motor. It is confirmed that the maximum torque of the optimized motor under both low speed and high speed conditions are higher than those of conventional motors because of relatively large q-axis inductance and small d-axis inductance.

  18. The impact of a discrepancy between actual and preferred living arrangements on life satisfaction among the elderly in China

    Jinqun Guan


    Full Text Available OBJECTIVES: To explore the effects of a discrepancy between actual and preferred living arrangements on the relationship between living arrangements and life satisfaction among the elderly in China. METHODS: Secondary analysis of the 2005 dataset of the Chinese Longitudinal Healthy Longevity Survey was performed. A binary logistic regression model was used to analyze the relationship between life satisfaction and living arrangements. RESULTS: Among those with concordant actual and preferred living arrangements, living in a nursing home increased the likelihood of life satisfaction, whereas living alone and living with a spouse decreased the likelihood of life satisfaction compared to living with the next generation and a spouse. Among those with discordant living arrangements, there were no differences in life satisfaction between the various living arrangements, except that living with a spouse increased life satisfaction compared to living with the next generation and a spouse. CONCLUSIONS: A discrepancy between actual and preferred living arrangements modifies the relationship between life satisfaction and actual living arrangement. Living in a nursing home is a good option for Chinese elder care only if the older individual emotionally accepts it. Living alone or with a spouse is not a good arrangement for elder care, even though it is often preferred by the elderly. Those with discordant living arrangements are more satisfied living with their spouses.

  19. The impact of a discrepancy between actual and preferred living arrangements on life satisfaction among the elderly in China.

    Guan, Jinqun; Li, Hui; Sun, Hong; Wang, Ting; Wu, Weiping


    To explore the effects of a discrepancy between actual and preferred living arrangements on the relationship between living arrangements and life satisfaction among the elderly in China. Secondary analysis of the 2005 dataset of the Chinese Longitudinal Healthy Longevity Survey was performed. A binary logistic regression model was used to analyze the relationship between life satisfaction and living arrangements. Among those with concordant actual and preferred living arrangements, living in a nursing home increased the likelihood of life satisfaction, whereas living alone and living with a spouse decreased the likelihood of life satisfaction compared to living with the next generation and a spouse. Among those with discordant living arrangements, there were no differences in life satisfaction between the various living arrangements, except that living with a spouse increased life satisfaction compared to living with the next generation and a spouse. A discrepancy between actual and preferred living arrangements modifies the relationship between life satisfaction and actual living arrangement. Living in a nursing home is a good option for Chinese elder care only if the older individual emotionally accepts it. Living alone or with a spouse is not a good arrangement for elder care, even though it is often preferred by the elderly. Those with discordant living arrangements are more satisfied living with their spouses.

  20. Social Practices of Juvenile Survival and Mortality: Child Care Arrangements in Mexico City.

    Gigengack, Roy


    Sketches the problems of urban "street" children in Mexico City, the emergence of collective child care arrangements, and the failure of the state to provide for child welfare. Describes community-based approaches arising in the absence of government action. (SK)

  1. Interaction Between Shelf Layout and Marketing Effectiveness and Its Impact on Optimizing Shelf Arrangements

    van Nierop, Erjen; Fok, Dennis; Franses, Philip Hans


    In this paper, we propose and operationalize a new method for optimizing shelf arrangements. We show that there are important dependencies between the layout of the shelf and stock-keeping unit (SKU) sales and marketing effectiveness. The importance of these dependencies is further shown by the

  2. Therapeutic Influence as a Function of Therapist Attire and the Seating Arrangement in an Initial Interview.

    Gass, Carlton S.


    Investigated the impact of therapist attire and seating arrangement on observers' perceptions of a therapist's attractiveness, expertise, and trustworthiness. Undergraduates (N=233) listened to an audiotaped interview while viewing a slide presentation. The casual attire/no desk setting elicited the highest attraction ratings, mediated by the…

  3. Weddings and war: marriage arrangements and celebrations in two Palestinian intifadas

    Johnson, P.; Abu Nahleh, L.; Moors, A.


    In our comparison of marriage arrangements and wedding celebrations during the first and the second intifada in Palestine, we focus on "political marriages" wherein the political activism and affiliation of the marital partners are of considerable importance. During the first intifada, political

  4. The institutional arrangements of innovation: Antecedents and performance effects of trust in high-tech alliances

    Jong, G. de; Klein Woolthuis, R.J.A.


    In this study we investigate the institutional arrangements of innovation processes in high-tech alliances, focusing on the role of trust. A major strength of the research is the opportunity to address antecedents as well as performance effects of trust. The antecedents of interorganizational trust

  5. The institutional arrangements of innovation : Antecendents and performance effects of trust in high-tech alliances

    de Jong, G.; Klein Woolthuis, R.


    In this study we investigate the institutional arrangements of innovation processes in high-tech alliances, focusing on the role of trust. A major strength of the research is the opportunity to address antecedents as well as performance effects of trust. The antecedents of interorganizational trust

  6. 42 CFR 411.357 - Exceptions to the referral prohibition related to compensation arrangements.


    ... promotion of a business arrangement or other activity that violates any Federal or State law. (vii) A... compensation for any other items or services that are furnished at a price that is consistent with fair market... increase in the Consumer Price Index—Urban All Items (CPI-U) for the 12-month period ending the...

  7. Dyscalculia and Access Arrangements for Exams and Assessments. NIACE Briefing Sheet 87

    National Institute of Adult Continuing Education, 2009


    Dyscalculia is considered to be a learning difficulty or difference. It is increasingly being recognised and "diagnosed" within adult learning. However, practitioners are often unclear about whether learners who are considered to have dyscalculia are entitled to access arrangements for examinations and assessments, and which access…

  8. Re-Presenting Subversive Songs: Applying Strategies for Invention and Arrangement to Nontraditional Speech Texts

    Charlesworth, Dacia


    Invention deals with the content of a speech, arrangement involves placing the content in an order that is most strategic, style focuses on selecting linguistic devices, such as metaphor, to make the message more appealing, memory assists the speaker in delivering the message correctly, and delivery ideally enables great reception of the message.…

  9. Effect of interaction heterogeneity on colloidal arrangements at a curved oil-water interface.

    Lee, Mina; Lee, Daeyeon; Park, Bum Jun


    We report the unique arrangement behaviour of colloidal particles at a curved oil-water interface. Particles trapped at a centrosymmetrically curved oil-water interface, formed by placing an oil lens at a neat air-water interface, organize into diverse arrangement structures due to electrostatic repulsion under the gravitational field. To reveal a possible mechanism behind the observed diversity, we investigate the interactions between pairs of particles at the curved oil-water interface. The magnitude of electrostatic repulsive interactions between pairs of particles is determined by minimizing the total potential of the particle pairs. We show that the pair interactions are quite heterogeneous, following a Gamma distribution. Using the experimentally determined pair potential and the heterogeneity in the potential as input parameters for Monte Carlo simulations, we show that such interaction heterogeneity affects the particle arrangements at the curved interface and results in an observed diversity in the particle arrangement structures. We believe that this work prompts further experimental and simulation studies to extensively understand hierarchical relations from small scale measurements (e.g., pair interactions and heterogeneity) to bulk scale properties (e.g., microstructure and interfacial rheology).

  10. Arranged Bursa Folk Songs for Fourhands Piano and Their Practice in Music Education Departments

    Demirci, Sirin Akbulut


    The article presents the results of a study carried out within the scope of a project entitled, "Arranged Bursa Folk Songs for Fourhands Piano Extended Piano Techniques and Teaching in Music Education Departments." It is number KUAP (E)-2014/28 of the Uludag University Scientific Research Projects Unit and was supported by the Bursa…

  11. Energy and low carbon development efforts in Ghana: institutional arrangements, initiatives, challenges and the way forward

    Tutu Benefoh, Daniel; Ackom, Emmanuel


    earlier energy and climate change local processes and structures but also help to mainstream low carbon agenda in economic activities and national development plans. For this to work however, require efficient institutions and effective institutional arrangements. Based on extensive literature analysis...

  12. Overweight, obesity and work functioning : The role of working-time arrangements

    Nigatu, Yeshambel T.; van de Ven, Hardy A.; van der Klink, Jac J. L.; Brouwer, Sandra; Reijneveld, Sijmen A.; Bultmann, Ute


    Background: Obesity is associated with productivity loss, but little is known about how obese workers function at work and also the role of working-time arrangements on this association is lacking. Therefore, the aim of this study was to examine the association of overweight and obesity with work fu

  13. Supervisory arrangements, LOLR and crisis management in a single European banking market

    Boot, A.W.A.


    In this paper I discuss some key issues related to supervisory arrangements in the EMU countries, and particularly those relating to the LOLR structure and crisis management. The focus will be on the responsibilities and powers of individual countries (and national central banks) vis-à-vis those at

  14. Organizing archival records a practical method of arrangement and description for small archives

    Carmicheal, David W


    Organizing Archival Records equips non-professional archivists with the skills to tackle one of the most challenging tasks of archiving: arranging and describing archival materials. Carmichael brings this third edition into the 21st century with extended discussions about computerizing the process, making descriptions available on the web, and organizing electronic records.

  15. 48 CFR 970.1504-1-4 - Types of contracts and fee arrangements.


    ... officials shall structure each contract and the elements of the work in such a manner that the risk is... contracts as appropriate. Proposed changes must be: Initiated by the contractor, innovative, applied to a... and government's organizations to prepare, evaluate, and administer the pricing arrangement or...

  16. Beginning teachers' self-efficacy and stress and the supposed effects of induction arrangements

    Helms-Lorenz, Michelle; Slof, Bert; Vermue, Carlien E.; Canrinus, Esther. T.


    Induction arrangements are implemented in schools all over the world to support beginning teachers (BTs) (novices) in gradually growing into their profession. The aim of this study is to gain more insight into two key psychological processes involved in the work of a qualified beginning teacher, nam

  17. Horizontal arrangement of anodes of microbial fuel cells enhances remediation of petroleum hydrocarbon-contaminated soil.

    Zhang, Yueyong; Wang, Xin; Li, Xiaojing; Cheng, Lijuan; Wan, Lili; Zhou, Qixing


    With the aim of in situ bioremediation of soil contaminated by hydrocarbons, anodes arranged with two different ways (horizontal or vertical) were compared in microbial fuel cells (MFCs). Charge outputs as high as 833 and 762C were achieved in reactors with anodes horizontally arranged (HA) and vertically arranged (VA). Up to 12.5 % of the total petroleum hydrocarbon (TPH) was removed in HA after 135 days, which was 50.6 % higher than that in VA (8.3 %) and 95.3 % higher than that in the disconnected control (6.4 %). Hydrocarbon fingerprint analysis showed that the degradation rates of both alkanes and polycyclic aromatic hydrocarbons (PAHs) in HA were higher than those in VA. Lower mass transport resistance in the HA than that of the VA seems to result in more power and more TPH degradation. Soil pH was increased from 8.26 to 9.12 in HA and from 8.26 to 8.64 in VA, whereas the conductivity was decreased from 1.99 to 1.54 mS/cm in HA and from 1.99 to 1.46 mS/cm in VA accompanied with the removal of TPH. Considering both enhanced biodegradation of hydrocarbon and generation of charge in HA, the MFC with anodes horizontally arranged is a promising configuration for future applications.

  18. The intellectual information system for management of geological and technical arrangements during oil field exploitation

    Markov, N. G.; Vasilyeva, E. E.; Evsyutkin, I. V.


    The intellectual information system for management of geological and technical arrangements during oil fields exploitation is developed. Service-oriented architecture of its software is a distinctive feature of the system. The results of the cluster analysis of real field data received by means of this system are shown.

  19. Photonic Band Gap Structures with Periodically Arranged Atoms in a Two-Dimensional Photonic Crystal

    LI Zhi-Yu; CHEN Fang; ZHOU Jian-Ying


    @@ Linear transmission, reflection and absorption spectra for a new two-dimensional photonic crystal with periodically arranged resonant atoms are examined. Numerical results show that a twin-gap structure with forbidden bands displaced from a non-doped bandgap structure can be produced as a result of atomic polarization. The absorption spectrum is also significantly altered compared to the single atom entity.

  20. Computer simulation of interlayer arrangement in cinnamate intercalated layered double hydroxides

    Greenwell, H. C.; Jones, W.; Newman, S. P.; Coveney, P. V.


    The interlayer arrangements of Mg-Al layered double hydroxides (LDHs) containing trans-cinnamate anions have been studied using molecular dynamics computer simulations. A modified version of the Dreiding forcefield was used to perform simulations of models with Mg/Al ratios of 2,3 and 6. For each Mg/Al ratio, two hydration states of 20 and 30 wt% water content were modelled. Close contacts between the olefinic carbons of the anion were analysed in an attempt to rationalize the potential outcome of the [2+2] photo-induced dimerization of the anions. In all instances, except for the model with Mg/Al=6 and 20 wt% water, the arrangement of the dimer pairs showed that syn-head-to-tail dimer formation was unfavourable. Preferred orientation of dimer pairs towards formation of head-to-head dimers was observed to undergo a transition from strongly favouring the syn-head-to-head dimer at low Mg/Al ratios to greater selectivity for the anti-head-to-head dimer with increasing Mg/Al ratio. The model with Mg/Al=6 and 20 wt% water content was observed to have a very disordered interlayer arrangement, with preference towards anion-pair arrangements favouring syn-head-to-tail dimer formation. The model with Mg/Al=6 and 30 wt% water content was predicted to exhibit only trans- cis isomerisation.

  1. 16 CFR 303.42 - Arrangement of information in advertising textile fiber products.


    ... textile fiber products. 303.42 Section 303.42 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE TEXTILE FIBER PRODUCTS IDENTIFICATION ACT § 303.42 Arrangement of information in advertising textile fiber products. (a) Where a...

  2. 42 CFR 417.546 - Physicians' services and other Part B supplier services furnished under arrangements.


    ... 42 Public Health 3 2010-10-01 2010-10-01 false Physicians' services and other Part B supplier....546 Physicians' services and other Part B supplier services furnished under arrangements. General principle. The amount paid by an HMO or CMP for physicians' services and other Part B supplier...

  3. Optimal arrangements of scanning heads for self-calibration of angle encoders

    Jiao, Yang; Dong, Zeguang; Ding, Ye; Liu, Pinkuan


    The calibration of the angle encoder is necessary to improve the accuracy of angle measurement in precision rotating devices. Due to the characteristics of in situ calibration of encoders, self-calibration methods depending on special arrangements of multiple scanning heads have been widely used. Conventional works usually arrange the scanning heads in a regularly distributed way, generally involving too many scanning heads, especially when more high order Fourier components of the encoder error are calibrated. This paper presents an optimization-based arrangement method for self-calibration of angle encoders. Fourier approaches are used to determine the error of encoder from the angle differences measured between scanning heads. The relations between detectable Fourier components of the error and angular intervals of the heads are obtained from the properties of transfer functions. The optimal arrangements for two and three scanning heads, including the adjustment tolerances of the heads with the range of tested Fourier orders, are presented. The results of simulations and experiments demonstrate that the proposed optimal schemes can realize the same performance of calibration but with fewer scanning heads, compared to the conventional methods.

  4. Functional Analysis and Treatment of Arranging and Ordering by Individuals with an Autism Spectrum Disorder

    Rodriguez, Nicole M.; Thompson, Rachel H.; Schlichenmeyer, Kevin; Stocco, Corey S.


    Of the diagnostic features of autism, relatively little research has been devoted to restricted and repetitive behavior, particularly topographically complex forms of restricted and repetitive behavior such as rigidity in routines or compulsive-like behavior (e.g., arranging objects in patterns or rows). Like vocal or motor stereotypy,…

  5. Semi-algebraic partition and basis of Borel-Moore homology of hyperplane arrangements

    Ito, Ko-Ki


    We describe an explicit semi-algebraic partition for the complement of the hyperplane arrangement such that each piece is contractible and forms a basis of Borel-Moore homology. We also give explicit correspondence between the de Rham cohomology and the Borel-Moore homology.

  6. Re-Presenting Subversive Songs: Applying Strategies for Invention and Arrangement to Nontraditional Speech Texts

    Charlesworth, Dacia


    Invention deals with the content of a speech, arrangement involves placing the content in an order that is most strategic, style focuses on selecting linguistic devices, such as metaphor, to make the message more appealing, memory assists the speaker in delivering the message correctly, and delivery ideally enables great reception of the message.…

  7. A Dynamic Perspective on Institutional Arrangements for Tourism, Conservation and Development in Eastern and Southern Africa

    Wijk, van J.J.; Lamers, M.A.J.; Duim, van der V.R.


    This book set out to present an overview of different institutional arrangements for tourism, conservation and development in eastern and southern Africa. These approaches range from conservancies in Namibia to community-based organizations in Botswana, private game reserves in South Africa and tour

  8. Arranging public support to unfold collaborative modes of governance in rural areas

    Wellbrock, W.; Roep, D.; Mahon, M.; Kairyte, E.; Nienaber, B.; Domínguez García, D.M.; Kriszan, M.; Farrell, M.


    Raising collective agency is key to successful place-based development approaches. Existing policy arrangements have, however, been criticised, suggesting a need to effectuate more collaborative modes of governance. This paper shall contribute to a better understanding of how public support can best

  9. Contractual arrangements and food quality certifications in the Mexican avocado industry

    Arana-Coronado, J.J.; Bijman, J.; Omta, S.W.F.; Oude Lansink, A.G.J.M.


    The adoption of private quality certifications in agrifood supply chains often requires specific investments by producers which can be safeguarded by choosing specific contractual arrangements. Based on a survey data from avocado producers in Mexico, this paper aims to analyze the impact of transact

  10. Improved electroabsorption demultiplexer by tandem-arrangement with semiconductor optical amplifier

    Hilliger, E.; Marembert, V.; Schubert, C.


    An electroabsorption demultiplexer was improved by operating it in a tandem-arrangement with an optically controlled SOA. An increase of the maximum data rate from 40 Gbit/s to 80 Gbit/s was experimentally demonstrated. The main drawback of the proposed scheme is the need of an additional optical...

  11. Setting the scene: Human activities, environmental impacts and governance arrangements in Antarctica

    Tin, T.; Lamers, M.A.J.; Liggett, D.; Maher, P.T.; Hughes, K.A.


    The scope and intensity of human activity in the Antarctic region has changed considerably over the past 100 years, resulting in significant modifications to the Antarctic environment and its ecosystems, and to the institutional arrangements governing human activities. Since the nineteenth century,

  12. Primary Early Care and Education Arrangements and Achievement at Kindergarten Entry. NCES 2016-070

    Rathbun, Amy; Zhang, Anlan


    Young children experience various types of early care and education environments the year before they enter kindergarten. Some children attend center-based arrangements such as preschools, childcare centers, or Head Start programs, while others are cared for in relatives' or nonrelatives' homes or are normally cared for only by their parents.…

  13. Personality Traits and Living Arrangements in Young Adulthood: Selection and Socialization

    Jonkmann, Kathrin; Thoemmes, Felix; Lüdtke, Oliver; Trautwein, Ulrich


    Based on the social investment principle and theories of social relationship differentiation, the present study was conducted to investigate whether personality differences in high school predict young adults' living arrangements (with roommates or a romantic partner, alone, or staying with parents) 2 years later (selection) and whether these…

  14. 47 CFR 1.9035 - Short-term de facto transfer leasing arrangements.


    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Short-term de facto transfer leasing... PROCEDURE Spectrum Leasing General Policies and Procedures § 1.9035 Short-term de facto transfer leasing...) and a spectrum lessee may enter into a short-term de facto transfer leasing arrangement in which...

  15. Future user-product arrangements: combining product impact and scenarios in design for multi age success

    Dorrestijn, Steven; Voort, van der Mascha; Verbeek, Peter-Paul


    The presence of four generations in business and organisations and the prevalence of ever-evolving technology, pose questions for technology design; a much wider range of user-product arrangements needs to be forecast and designed for. To provide a theoretical framework that accommodates the need to




    Full Text Available Wesselényi Domain of Jibou, a Model of Multisecular Arrangement. Nowadays the nobiliary domains arouse the interest of specialists from various field and tourists. The typical nobility constructions are attractive both by their residential function –including curias, castles and palaces in Transylvania – and by the economic function of annexes composed of: mills, barns, stables, riding houses etc. These domains functioned as command centres of territorial arrangements from Medieval Age, premodern and modern ages with implications on the economic and social progress of ages and administrative structures, but also subsequent development. Our study aims to make a presentation of the nobiliary domain Wesselényi in Jibou, aiming to the identification of functions and strategic arrangements for valorisation of the domain as irradiation models of welfare and multiple values, which became a multisecular standard by: emblematic characters, decisive actions carried out by these characters, in Transylvania, Hungary and the Habsburg Empire, to which the Principality of Transylvania belonged until the Great Union of 1918. The management of Jibou domain of Wesselényi family was carried out by various state institutions after the nationalization of 1945, stipulated by Law 187/1945, occasion of new arrangement and valorisation strategies which will also be presented.

  17. Impression Formation and Classroom Design: The Impact of Spatial Arrangement and Neatness on Judgments of Teachers.

    Weinstein, Carol S.; Woolfolk, Anita E.

    A study was conducted to examine the impact of classroom arrangement (open versus traditional) and tidiness (messy versus neat) on observers' expectations about a teacher. A heterogeneous sample of college students was shown color slides of vacant elementary classrooms varying in terms of these two dimensions and asked to indicate their…

  18. Sleep Arrangements, Parent-Infant Sleep during the First Year, and Family Functioning

    Teti, Douglas M.; Shimizu, Mina; Crosby, Brian; Kim, Bo-Ram


    The present longitudinal study addressed the ongoing debate regarding the benefits and risks of infant-parent cosleeping by examining associations between sleep arrangement patterns across the first year of life and infant and parent sleep, marital and family functioning, and quality of mothers' behavior with infants at bedtime. Patterns of infant…

  19. Interaction Between Shelf Layout and Marketing Effectiveness and Its Impact on Optimizing Shelf Arrangements

    van Nierop, Erjen; Fok, Dennis; Franses, Philip Hans


    In this paper, we propose and operationalize a new method for optimizing shelf arrangements. We show that there are important dependencies between the layout of the shelf and stock-keeping unit (SKU) sales and marketing effectiveness. The importance of these dependencies is further shown by the subs

  20. Self-Arrangement of Fleeting Student Pairs: A Web 2.0 Approach for Peer Tutoring

    Westera, Wim; de Bakker, Gijs; Wagemans, Leo


    This article presents a Web 2.0 approach for the arrangement of peer tutoring in online learning. In online learning environments, the learners' expectations of obtaining frequent, one-to-one support from their teachers tend to increase the teachers' workloads to unacceptably high levels. To address this problem of workload a self-organised peer…

  1. Analysis of User Choice Resourcing Arrangements in March 2004. Working Paper No. 58

    Selby Smith, C.


    This Working Paper contains three sections: the background to existing User Choice resourcing principles and their interrelationships as of March 2004; analysis of the existing arrangements, including their consistency with each other and with the User Choice principles agreed by Ministers; and concluding comments. The author found a considerable…

  2. Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis

    Kimura, Yumi; Matsugaki, Aira; Sekita, Aiko; Nakano, Takayoshi


    Intact bone tissue exhibits a characteristic anisotropic microstructure derived from collagen fiber alignment and the related c-axis orientation of apatite crystals, which govern the mechanical properties of bone tissue. In contrast, tumor-invaded bone exhibits a disorganized, less-aligned microstructure that results in severely disrupted mechanical function. Despite its importance both in basic principle and in therapeutic applications, the classical understanding of bone metastasis is limited to alterations in bone mass regulated by metastatic cancer cells. In this study, we demonstrate a novel mechanism underlying the disruption of bone tissue anisotropy in metastasized bone. We observed that direct attack by cancer cells on osteoblasts induces the less-organized osteoblast arrangement. Importantly, the crystallographic anisotropy of bone tissue is quantitatively determined by the level of osteoblast arrangement. Osteoblast arrangement was significantly disrupted by physical contact with cancer cells such as osteolytic melanoma B16F10, breast cancer MDA-MB-231, and osteoblastic prostate cancer MDA-PCa-2b cells. The present findings demonstrate that the abnormal arrangement of osteoblasts induced by physical contact with cancer cells facilitates the disorganized microstructure of metastasized bone. PMID:28303941

  3. School-Age Child Care Arrangements. Research-to-Policy Connections No. 4

    Lawrence, Sharmila; Kreader, J. Lee


    School-age children ages 5 through 12 years spend their out-of-school time in many different types of arrangements. In addition to parental care, these include relative care, non-relative care (either in their own or another family's home), center- or school-based programs, sports and extracurricular activities, summer activities, and self-care.…

  4. Direct dimethyl-ether (DME) synthesis by spatial patterned catalyst arrangement. A modeling and simulation study

    McBride, K.; Turek, T.; Guettel, R. [Clausthal Univ. of Technology (Germany). Inst. of Chemical Process Engineering


    The effect of spatially patterned catalyst beds was investigated for direct DME synthesis from synthesis gas as an example. A layered arrangement of methanol synthesis and dehydration catalyst was chosen and studied by numerical simulation under typical operating conditions for single-step DME synthesis. It was revealed that catalyst layers significantly influence the DME productivity. With an increasing number of layers from 2 to 40, an increase in DME productivity was observed approaching the performance of a physical catalyst mixture for an infinite number of layers. The results prove that a physical mixture of methanol synthesis and dehydration catalyst achieves the highest DME productivity under operating conditions chosen in this study. This can be explained by the higher average methanol concentration for the layered catalyst arrangement and thus stronger equilibrium constraints for the methanol synthesis reaction. Essentially, the layered catalyst arrangement is comparable to a cascade model of the two-step process, which is less efficient in terms of DME yield than the single-step process. However, since a significant effect was found, the layered catalyst arrangement could be beneficial for other reaction systems. (orig.)

  5. Unusual cervical nerve root arrangement exposed during surgery: case report and review of the literature.

    Zrinzo, L; Ashkan, K; Johnston, F


    Anatomical variations of neural structures in the cervical spine are rare and are not necessarily visible on pre-operative imaging. The authors report an unusual arrangement of neural structures identified during cervical foraminotomy. Anatomical variations of the cervical nerve roots are reviewed and their importance in neurosurgical practice is discussed.

  6. 26 CFR 1.7701(l)-3 - Recharacterizing financing arrangements involving fast-pay stock.


    ... involving fast-pay stock. 1.7701(l)-3 Section 1.7701(l)-3 Internal Revenue INTERNAL REVENUE SERVICE....7701(l)-3 Recharacterizing financing arrangements involving fast-pay stock. (a) Purpose and scope. This... corporation has fast-pay stock outstanding for any part of its taxable year. (2) Fast-pay stock—(i)...

  7. Racial Differences in the Determinants of Living Arrangements of Widowed and Divorced Elderly Women.

    Choi, Namkee G.


    Analyzed within-racial group differences in the determinants of living arrangements of widowed white (n=1,807), widowed nonwhite (n=269), divorced white (n=684), and divorced nonwhite (n=126) elderly women. Results indicated race was not just one explanatory variable but was the second most and the most crucial explanatory variable for widows and…

  8. Are the kids alright? Essays on postdivorce residence arrangements and children's well-being

    Westphal, S.K.


    This dissertation examines changes in postdivorce parenting over time and investigates the consequences of postdivorce residence arrangements for children’s well-being. It improves on earlier research in several ways. First, to understand changes in postdivorce parenting, the role of father

  9. 26 CFR 1.414(w)-1 - Permissible withdrawals from eligible automatic contribution arrangements.


    ... Pensions, Annuities, Retirement or Profit-Sharing Plans, IRAs, Insurance Contracts, etc.,” as described in... OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus... simplified employee pension the terms of which provide for a salary reduction arrangement described...

  10. Serving a heterogeneous Muslim identity? Private governance arrangements of halal food in the Netherlands

    Kurth, Laura; Glasbergen, Pieter


    The consumption of halal food may be seen as an expression of the Muslim identity. Within Islam, different interpretations of ‘halal’ exist and the pluralistic Muslim community requests diverse halal standards. Therefore, adaptive governance arrangements are needed in the halal food market. Globaliz

  11. 26 CFR 1.62-2 - Reimbursements and other expense allowance arrangements.


    ... expenses of traveling away from home (exclusive of transportation costs to and from destination) or mileage... expense allowance arrangement with a payor (the employer, its agent, or a third party). Section 62(c... services as an employee of the employer. The payment may be actually received from the employer, its...

  12. Inequality in new global governance arrangements: the North-South divide in transnational municipal networks

    Bouteligier, S.


    Networks are often portrayed as more equal governance arrangements because of their horizontal character. Power relations within networks are neglected as the collaborative activities receive the bulk of attention. However, from a critical reading of the network and flows literature we know that net

  13. 44 CFR 352.26 - Arrangements for Federal response in the licensee offsite emergency response plan.


    ... NUCLEAR POWER PLANTS: EMERGENCY PREPAREDNESS PLANNING Federal Participation § 352.26 Arrangements for... services at Federal hospitals; and (5) Ensuring the creation and maintenance of channels of communication from commercial nuclear power plant licensees to State and local governments and to surrounding...

  14. 41 CFR 301-50.8 - Are there any limits on travel arrangements I may make?


    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Are there any limits on travel arrangements I may make? 301-50.8 Section 301-50.8 Public Contracts and Property Management... Hotel and Motel Fire Safety Act of 1990 (the Act), as amended (see 5 U.S.C. 5707a). (2) When selecting a...

  15. The Relationship between Living Arrangement, Academic Performance, and Engagement among First-Year College Students

    Balfour, Denise Shata


    One way students become engaged in their undergraduate experience is through place of residence. Factors associated with high academic performance suggest high levels of engagement in campus life. This study investigated the relationship between living arrangement and the academic performance of first-year, full-time undergraduate students. The…

  16. Rights-Based Education for South Asian Sponsored Wives in International Arranged Marriages

    Merali, Noorfarah


    The Family Class Category of Canada's Immigration Policy exists with the key objective of family unification. Among Canada's second largest immigrant group, the South Asians, the cultural practice of arranged marriage is applied across international borders, leading to spousal sponsorship. Existing research on South Asian sponsored wives suggests…

  17. Differential Effects of Seating Arrangements on Disruptive Behavior of Fifth Grade Students during Independent Seatwork

    Bicard, David F.; Ervin, Angela; Bicard, Sara C.; Baylot-Casey, Laura


    We investigated teacher versus student seat selection in the context of group and individual seating arrangements. Disruptive behavior during group seating occurred at twice the rate when students chose their seats than when the teacher chose. During individual seating, disruptive behavior occurred more than three times as often when the students…

  18. The Experience of Arranged Marriage by the 1.5 Generation Asian Indian College Students

    Burton, Rita


    The purpose of the study was to investigate the experiences of arranged marriage by the 1.5 Generation Asian Indian college students. The researcher identified 10 participants who met the following criteria: (a) were born in India to Asian Indian parents, (b) migrated to the United States under the age of 15, (c) were college students between the…

  19. Marriage by Arrangement: A Metaphor for One Particular Use of Network Therapy.

    Reed, C. Y.


    Uses metaphor of the wedding in an arranged marriage to describe the process of using a network meeting to overcome resistance and engage a hostile adolescent and her family in a residential treatment program. Review of the literature is followed by description of a clinical case. Practical and theoretical issues are discussed. (Author/NB)

  20. Rights-Based Education for South Asian Sponsored Wives in International Arranged Marriages

    Merali, Noorfarah


    The Family Class Category of Canada's Immigration Policy exists with the key objective of family unification. Among Canada's second largest immigrant group, the South Asians, the cultural practice of arranged marriage is applied across international borders, leading to spousal sponsorship. Existing research on South Asian sponsored wives suggests…